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Search of human proteins with 4506751
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506751 restin isoform a [Homo sapiens]
(1427 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506751 restin isoform a [Homo sapiens] 2732 0.0
gi|38044112 restin isoform b [Homo sapiens] 2648 0.0
gi|116008447 CAP-GLY domain containing linker protein 2 isoform ... 832 0.0
gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2... 760 0.0
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 194 4e-49
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 190 7e-48
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 188 4e-47
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 188 4e-47
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 187 5e-47
gi|71061468 centromere protein E [Homo sapiens] 185 3e-46
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 184 4e-46
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 184 7e-46
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 183 9e-46
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 182 2e-45
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 181 6e-45
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 180 1e-44
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 177 5e-44
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 177 5e-44
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 177 5e-44
gi|156104908 myosin heavy chain 6 [Homo sapiens] 176 1e-43
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 176 2e-43
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 176 2e-43
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 175 3e-43
gi|18496983 CAP-GLY domain containing linker protein 3 [Homo sap... 173 9e-43
gi|31982881 CAP-GLY domain containing linker protein family, mem... 173 1e-42
gi|21735548 centrosomal protein 2 [Homo sapiens] 172 2e-42
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 172 3e-42
gi|58530840 desmoplakin isoform I [Homo sapiens] 170 8e-42
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 169 2e-41
gi|55770834 centromere protein F [Homo sapiens] 169 2e-41
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 2732 bits (7081), Expect = 0.0
Identities = 1427/1427 (100%), Positives = 1427/1427 (100%)
Query: 1 MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV 60
MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV
Sbjct: 1 MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV 60
Query: 61 GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR 120
GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR
Sbjct: 61 GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR 120
Query: 121 PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS 180
PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS
Sbjct: 121 PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS 180
Query: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
Query: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
Query: 301 ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK 360
ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK 360
Query: 361 QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA 420
QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA
Sbjct: 361 QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA 420
Query: 421 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKA 480
DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKA
Sbjct: 421 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKA 480
Query: 481 DKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 540
DKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE
Sbjct: 481 DKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 540
Query: 541 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 600
ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH
Sbjct: 541 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 600
Query: 601 ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 660
ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ
Sbjct: 601 ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 660
Query: 661 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 720
HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT
Sbjct: 661 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 720
Query: 721 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 780
LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK
Sbjct: 721 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 780
Query: 781 KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 840
KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK
Sbjct: 781 KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 840
Query: 841 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 900
ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE
Sbjct: 841 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 900
Query: 901 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN
Sbjct: 901 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
Query: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER
Sbjct: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
Query: 1021 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1080
ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA
Sbjct: 1021 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1080
Query: 1081 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1140
MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM
Sbjct: 1081 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1140
Query: 1141 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLL 1200
EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLL
Sbjct: 1141 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLL 1200
Query: 1201 EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS 1260
EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS
Sbjct: 1201 EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS 1260
Query: 1261 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV 1320
VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV
Sbjct: 1261 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV 1320
Query: 1321 DLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTE 1380
DLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTE
Sbjct: 1321 DLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTE 1380
Query: 1381 DCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF 1427
DCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF
Sbjct: 1381 DCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF 1427
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 2648 bits (6864), Expect = 0.0
Identities = 1392/1427 (97%), Positives = 1392/1427 (97%), Gaps = 35/1427 (2%)
Query: 1 MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV 60
MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV
Sbjct: 1 MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV 60
Query: 61 GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR 120
GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR
Sbjct: 61 GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR 120
Query: 121 PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS 180
PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS
Sbjct: 121 PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS 180
Query: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
Query: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
Query: 301 ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK 360
ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK 360
Query: 361 QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA 420
QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA
Sbjct: 361 QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA 420
Query: 421 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKA 480
DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE
Sbjct: 421 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE------------------------ 456
Query: 481 DKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 540
VATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE
Sbjct: 457 -----------VATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 505
Query: 541 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 600
ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH
Sbjct: 506 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 565
Query: 601 ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 660
ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ
Sbjct: 566 ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 625
Query: 661 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 720
HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT
Sbjct: 626 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 685
Query: 721 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 780
LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK
Sbjct: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 745
Query: 781 KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 840
KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK
Sbjct: 746 KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 805
Query: 841 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 900
ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE
Sbjct: 806 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 865
Query: 901 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN
Sbjct: 866 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 925
Query: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER
Sbjct: 926 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
Query: 1021 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1080
ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA
Sbjct: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
Query: 1081 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1140
MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM
Sbjct: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
Query: 1141 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLL 1200
EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLL
Sbjct: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLL 1165
Query: 1201 EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS 1260
EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS
Sbjct: 1166 EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS 1225
Query: 1261 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV 1320
VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV
Sbjct: 1226 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV 1285
Query: 1321 DLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTE 1380
DLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTE
Sbjct: 1286 DLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTE 1345
Query: 1381 DCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF 1427
DCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF
Sbjct: 1346 DCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF 1392
>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
[Homo sapiens]
Length = 1046
Score = 832 bits (2149), Expect = 0.0
Identities = 487/1115 (43%), Positives = 701/1115 (62%), Gaps = 96/1115 (8%)
Query: 3 MLKPSGLKAPTKILKPGSTALKTPT-------AVVAPVEKTISSEKASSTPSS------- 48
M KPSGLK P + K S +T T AV A ++ K SS PSS
Sbjct: 1 MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
Query: 49 ---------ETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99
E ++F+ DF VGERVWVNG KPG +Q+LGETQFAPGQWAG+VLD+P+GKN
Sbjct: 61 PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
Query: 100 DGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSS 159
DG+V GVRYF+C L+GIFTRPSKLTR+ AE + + + A + S S ++
Sbjct: 121 DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQN---LSLHSGTAT 177
Query: 160 SPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVL 219
P T IP + S +++ KT +ES SNLS++GS+K+GE++L++GDRVL
Sbjct: 178 PPLTSRVIPLRESV-----------LNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVL 226
Query: 220 VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVT 279
VGGTK GVVR++GETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQC PK+GLFAP+HKV
Sbjct: 227 VGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVI 286
Query: 280 KIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTET 339
+IGFPST+PAKAK + MA ++L SPS+SS+SS+SSVASSV RPSR+GLLTET
Sbjct: 287 RIGFPSTSPAKAKKT---KRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTET 343
Query: 340 SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGH 399
SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSH+ E+E+E+AL + H
Sbjct: 344 SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
Query: 400 DQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQT 459
+Q+V E E K+ + R +VE+ +EKV+L NQLEEE+RKVEDLQFRVEEESITKGDLETQT
Sbjct: 404 EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQT 463
Query: 460 KLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELR 519
+LEHARI ELEQSLL EK +A++L REL D R+ TV+EKSR+++LE++L LR E+ EL+
Sbjct: 464 QLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQ 523
Query: 520 R-RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK 578
+ L S P D + +L+ L+E+L +HQRE L++ + + +Q E+
Sbjct: 524 QCLLHSGPPPPDHPDAAEILR----LRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD 579
Query: 579 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 638
L A EK ++E LK K++ A EN ++ WKSKL++ + HQ+++E+LK + + G
Sbjct: 580 KLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGP 639
Query: 639 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 698
G + E ELK +E +++++Q E+ NLQ + D E A H KE EALR KL + +E
Sbjct: 640 GAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGL 699
Query: 699 LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 758
R++L+ QH +E+++ ++ ++AE++V ELE L + Q + I+ Q+
Sbjct: 700 QRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA 759
Query: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
E+K+LD + L++A ++GK E++ LR++L AE +++ + E+ +S T ++ +
Sbjct: 760 EKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAV------EALCSSQHTHMIESND 813
Query: 819 LKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFN 878
+ E + KET+E +Q+ KL++++++
Sbjct: 814 IS--------EETIRTKETVE----------------------GLQD---KLNKRDKEVT 840
Query: 879 MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 938
L+S E LR ++ +E+K + +++ + L+K K +LE ++ + + + D S QL ++
Sbjct: 841 ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 900
Query: 939 ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 998
EL KER + EL++ L +AN ++ ++ + KAE +E +K +++ + L KL+
Sbjct: 901 ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE--QKLKDDIRGLREKLT 958
Query: 999 DLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLL 1058
L+K+ S + RY + + L LQ L+ TED L+ A ++ +
Sbjct: 959 GLDKEKSLSDQR------RYSLIDPSSAPE----LLRLQHQLMSTEDALRDALDQAQQVE 1008
Query: 1059 QELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1093
+ +E +R DKA+ + A I +Q +K E
Sbjct: 1009 KLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQE 1043
Score = 81.6 bits (200), Expect = 5e-15
Identities = 151/771 (19%), Positives = 311/771 (40%), Gaps = 139/771 (18%)
Query: 596 SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK-GLGTETAEFAELK----T 650
+K + + V AL S ++I+S + S+ GL TET+ K T
Sbjct: 296 AKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTT 355
Query: 651 QIEKMRLDYQHEIENLQNQQDSERAAHAK----------EMEALRAKLMKVIKEKENSLE 700
+++ + Q IE L ++D ERA AK E+ L+A+ + + E E L+
Sbjct: 356 ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQ 415
Query: 701 AIRSKLDKAEDQHLV---EMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL-- 755
R ++ + + ++E+ K+++ + +V+E + + QT++ +L
Sbjct: 416 RARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQ 475
Query: 756 -----KATEEKLL-DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE------------ 797
KA E+LL +L R + KS + +L ++L +I+ L+
Sbjct: 476 SLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPD 535
Query: 798 --------------IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQ 843
+ + E + S + R+ + LK Q + ++ E +E+
Sbjct: 536 HPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKA--YQAEVDKLRAANEKYAQEVA 593
Query: 844 ILKEKFAEASEEAVSVQRSMQETVNKL---HQK----------------EEQFNMLSSDL 884
LK+K +A+ E + + + + ++ L HQK +++ L + +
Sbjct: 594 GLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVM 653
Query: 885 EKLREN----LADMEAKF--------REKDEREEQLIKAKEKL----ENDIAEIMKMSGD 928
E ++ L +++AK +EK+ E+L +A+E+L + A++ +
Sbjct: 654 EGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQ 713
Query: 929 NSSQLTKMNDELR---LKERDVEELQLKLTKANENASFLQK--SIEDMTVKAEQSQQEAA 983
+ +L + D+ R L+ ++E+L ++ + FL++ S+ + + + Q A
Sbjct: 714 HRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAE 773
Query: 984 KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERAT--SETKTKHEEILQNLQKTLL 1041
+ ++E + L KL E +++ C + SE + +E ++ LQ
Sbjct: 774 AQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQ---- 829
Query: 1042 DTEDKLKGAREENSGLLQELEELRKQAD----KAKAAQTAEDAMQIMEQMTKEKTETLAS 1097
DKL +E + L + E LR Q K K+ + DA+ KEK A
Sbjct: 830 ---DKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDAL------LKEKRRLEAE 880
Query: 1098 LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1157
LE + +L + + L+ LN+ + LL N+ +++ A +
Sbjct: 881 LETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWR 940
Query: 1158 SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1217
++ KL +++ R+++T L++E+S L ++R S + E
Sbjct: 941 IKE--------QKLKDDIRGLREKLTG---LDKEKS------LSDQRRYSLIDPSSAPEL 983
Query: 1218 ASLQKSISITSALLTEKDAELEKLRNEVTVLR---------GENASAKSLH 1259
LQ + T L + + +++ + +R G + SA +H
Sbjct: 984 LRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIH 1034
Score = 61.2 bits (147), Expect = 7e-09
Identities = 98/451 (21%), Positives = 197/451 (43%), Gaps = 54/451 (11%)
Query: 931 SQLTKMNDELRLKERDVEEL-------QLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 983
S T + + L+ K++ +E+L + ++ KA + ++K I + + EQ EA
Sbjct: 352 SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
Query: 984 KKHEEEK---KELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1040
+K + + + + ++ DL ++E + ++L+ R E S TK E Q +
Sbjct: 412 EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEE-SITKGDLETQTQLEHARI 470
Query: 1041 LDTEDKLKGAREENSGLLQELEE--LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL 1098
+ E L + + LL+EL + L A+K++ Q E+ + + +E + L
Sbjct: 471 GELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEE-LTLRRGEIEELQQCLLHS 529
Query: 1099 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK-MEEFRKEIETLKQAAAQK 1157
+ E+ L+E L +E + +L + +K ++ ++ E++ L+ A +
Sbjct: 530 GPPPPDHPDAA-EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKY 588
Query: 1158 SQQLSALQE-------ENVKLAEELGRSRDEVTS-HQK-LEEERSVLNN-------QLLE 1201
+Q+++ L++ EN+ L + D + S HQK LE+ ++ LN+ ++ E
Sbjct: 589 AQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGE 648
Query: 1202 MKKRESKFIKDADEEKASLQKSISITSAL-LTEKDAELEKLRNEVTVLRGENASAKSLHS 1260
+K + E +LQ + +A+ + EK+A EKL+ L G
Sbjct: 649 LKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAG---------- 698
Query: 1261 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI- 1319
+Q +++++ LELQ +++R+ + + + D + R Q I+FL I
Sbjct: 699 -LQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQIS 757
Query: 1320 ---------VDLQRKNQDLKMKVEMMSEAAL 1341
LQR K +VE + E L
Sbjct: 758 LAEKKMLDYERLQRAEAQGKQEVESLREKLL 788
>gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2
[Homo sapiens]
Length = 1011
Score = 760 bits (1963), Expect = 0.0
Identities = 457/1114 (41%), Positives = 666/1114 (59%), Gaps = 129/1114 (11%)
Query: 3 MLKPSGLKAPTKILKPGSTALKTPT-------AVVAPVEKTISSEKASSTPSS------- 48
M KPSGLK P + K S +T T AV A ++ K SS PSS
Sbjct: 1 MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
Query: 49 ---------ETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99
E ++F+ DF VGERVWVNG KPG +Q+LGETQFAPGQWAG+VLD+P+GKN
Sbjct: 61 PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
Query: 100 DGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSS 159
DG+V GVRYF+C L+GIFTRPSKLTR+ AE + + + A + S S ++
Sbjct: 121 DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQN---LSLHSGTAT 177
Query: 160 SPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVL 219
P T IP + S +++ KT +ES SNLS++GS+K+GE++L++GDRVL
Sbjct: 178 PPLTSRVIPLRESV-----------LNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVL 226
Query: 220 VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVT 279
VGGTK GVVR++GETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQC PK+GLFAP+HKV
Sbjct: 227 VGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVI 286
Query: 280 KIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTET 339
+IGFPST+PAKAK + MA ++L SPS+SS+SS+SSVASSV RPSR+GLLTET
Sbjct: 287 RIGFPSTSPAKAKKT---KRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTET 343
Query: 340 SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGH 399
SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSH+ E+E+E+AL + H
Sbjct: 344 SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
Query: 400 DQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQT 459
+Q+V E E K+ + R +VE+ +EKV+L NQLEEE+RKVEDLQFRVEEESITKGDLE T
Sbjct: 404 EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTT 463
Query: 460 KLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELR 519
E +R+ +LE+ L + + ++LQ+ L
Sbjct: 464 VAEKSRVLQLEEELTLRRGEIEELQQCL-------------------------------- 491
Query: 520 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKA 579
L S P D + +L+ L+E+L +HQRE L++ + + +Q E+
Sbjct: 492 --LHSGPPPPDHPDAAEILR----LRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDK 545
Query: 580 LYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLG 639
L A EK ++E LK K++ A EN ++ WKSKL++ + HQ+++E+LK + + G G
Sbjct: 546 LRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPG 605
Query: 640 TETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSL 699
+ E ELK +E +++++Q E+ NLQ + D E A H KE EALR KL + +E
Sbjct: 606 AQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQ 665
Query: 700 EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATE 759
R++L+ QH +E+++ ++ ++AE++V ELE L + Q + I+ Q+ E
Sbjct: 666 RHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAE 725
Query: 760 EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL 819
+K+LD + L++A ++GK E++ LR++L AE +++ + E+ +S T ++ ++
Sbjct: 726 KKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAV------EALCSSQHTHMIESNDI 779
Query: 820 KLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNM 879
E + KET+E +Q+ KL++++++
Sbjct: 780 S--------EETIRTKETVE----------------------GLQD---KLNKRDKEVTA 806
Query: 880 LSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDE 939
L+S E LR ++ +E+K + +++ + L+K K +LE ++ + + + D S QL ++ E
Sbjct: 807 LTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQE 866
Query: 940 LRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 999
L KER + EL++ L +AN ++ ++ + KAE +E +K +++ + L KL+
Sbjct: 867 LLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE--QKLKDDIRGLREKLTG 924
Query: 1000 LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ 1059
L+K+ S + RY + + L LQ L+ TED L+ A ++ + +
Sbjct: 925 LDKEKSLSDQR------RYSLIDPSSAPE----LLRLQHQLMSTEDALRDALDQAQQVEK 974
Query: 1060 ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1093
+E +R DKA+ + A I +Q +K E
Sbjct: 975 LMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQE 1008
Score = 81.3 bits (199), Expect = 6e-15
Identities = 150/746 (20%), Positives = 309/746 (41%), Gaps = 124/746 (16%)
Query: 596 SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK-GLGTETAEFAELK----T 650
+K + + V AL S ++I+S + S+ GL TET+ K T
Sbjct: 296 AKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTT 355
Query: 651 QIEKMRLDYQHEIENLQNQQDSERAAHAK----------EMEALRAKLMKVIKEKENSLE 700
+++ + Q IE L ++D ERA AK E+ L+A+ + + E E L+
Sbjct: 356 ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQ 415
Query: 701 AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE 760
R ++ + + D N+L+E KV++L Q + E++ + A +
Sbjct: 416 RARLLVESVRKEKV----DLSNQLEEERRKVEDL---QFRVEEESITKGDLELTTVAEKS 468
Query: 761 KLLDLDALRKASSEGKSEMKKLRQQL-----------EAAE-KQIKHLEIEKNAESSKAS 808
++L L+ + + + E+++L+Q L +AAE +++ + + E + S
Sbjct: 469 RVLQLE---EELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRES 525
Query: 809 SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN 868
+ R+ + LK Q + ++ E +E+ LK+K +A+ E + + + + ++
Sbjct: 526 GVLRDKYEKALKA--YQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLD 583
Query: 869 KL---HQK----------------EEQFNMLSSDLEKLREN----LADMEAKF------- 898
L HQK +++ L + +E ++ L +++AK
Sbjct: 584 SLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMH 643
Query: 899 -REKDEREEQLIKAKEKL----ENDIAEIMKMSGDNSSQLTKMNDELR---LKERDVEEL 950
+EK+ E+L +A+E+L + A++ + + +L + D+ R L+ ++E+L
Sbjct: 644 VKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKL 703
Query: 951 QLKLTKANENASFLQK--SIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSH 1008
++ + FL++ S+ + + + Q A + ++E + L KL E +++
Sbjct: 704 DVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVE 763
Query: 1009 NQCQELKARYERAT--SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1066
C + SE + +E ++ LQ DKL +E + L + E LR
Sbjct: 764 ALCSSQHTHMIESNDISEETIRTKETVEGLQ-------DKLNKRDKEVTALTSQTEMLRA 816
Query: 1067 QAD----KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKN 1122
Q K K+ + DA+ KEK A LE + +L + + L+
Sbjct: 817 QVSALESKCKSGEKKVDAL------LKEKRRLEAELETVSRKTHDASGQLVLISQELLRK 870
Query: 1123 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1182
LN+ + LL N+ +++ A + ++ KL +++ R+++
Sbjct: 871 ERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE--------QKLKDDIRGLREKL 922
Query: 1183 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLR 1242
T L++E+S L ++R S + E LQ + T L + + +++
Sbjct: 923 TG---LDKEKS------LSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVE 973
Query: 1243 NEVTVLR---------GENASAKSLH 1259
+ +R G + SA +H
Sbjct: 974 KLMEAMRSCPDKAQTIGNSGSANGIH 999
Score = 58.5 bits (140), Expect = 4e-08
Identities = 92/411 (22%), Positives = 183/411 (44%), Gaps = 64/411 (15%)
Query: 980 QEAAKKHEEEKKEL--ERKLSDLEKKMETSH-----NQCQELKARYERATSETKTKHEE- 1031
QEA K+ ++ ++L ER L E TSH + LKA++E+ +E + K +
Sbjct: 358 QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRA 417
Query: 1032 --ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA--MQIMEQM 1087
++++++K +D ++L+ R + L +EE + AE + +Q+ E++
Sbjct: 418 RLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEEL 477
Query: 1088 TKEKTETLASLEDTKQT---------NAKLQNELDTLKENNLKNVEELNKSKELLTVENQ 1138
T + E +E+ +Q + E+ L+E L +E + +L + +
Sbjct: 478 TLRRGE----IEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYE 533
Query: 1139 K-MEEFRKEIETLKQAAAQKSQQLSALQE-------ENVKLAEELGRSRDEVTS-HQK-L 1188
K ++ ++ E++ L+ A + +Q+++ L++ EN+ L + D + S HQK L
Sbjct: 534 KALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSL 593
Query: 1189 EEERSVLNN-------QLLEMKKRESKFIKDADEEKASLQKSISITSAL-LTEKDAELEK 1240
E+ ++ LN+ ++ E+K + E +LQ + +A+ + EK+A EK
Sbjct: 594 EDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREK 653
Query: 1241 LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQ 1300
L+ L G +Q +++++ LELQ +++R+ + + +
Sbjct: 654 LQEAQEELAG-----------LQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEK 702
Query: 1301 ADEDERAQESQIDFLNSVI----------VDLQRKNQDLKMKVEMMSEAAL 1341
D + R Q I+FL I LQR K +VE + E L
Sbjct: 703 LDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLL 753
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 194 bits (494), Expect = 4e-49
Identities = 229/1035 (22%), Positives = 459/1035 (44%), Gaps = 142/1035 (13%)
Query: 351 TALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKM 410
T ++ L+E ++ +QLL E+++ ++ T E E+ A ELE +
Sbjct: 869 TKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ----ELEEIL 924
Query: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELE 470
L + VE + L N+ ++ + ++DL+ +++EE + L+ + A+IK++E
Sbjct: 925 HDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKME 984
Query: 471 QSLLFEKTKADKL--QRELEDTRVATVS-----EKSRIMELEKDLALRVQEVAELRRRLE 523
+ +L + + K +++L + R+A S E+ + L K + +++L RL+
Sbjct: 985 EEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK 1044
Query: 524 SNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTA 583
+ QE+ + KL+ TD Q +I L+ E+K
Sbjct: 1045 KEE---------KTRQELEKAKRKLDGETTDLQDQIAELQAQI--------DELKL---- 1083
Query: 584 TEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETA 643
+L+K+ E L+ L + E L K+ + Q + EL+ F +E A
Sbjct: 1084 --QLAKKEEELQGALARGDDE-----TLHKNNALKVVRELQAQIAELQEDFE----SEKA 1132
Query: 644 EFAELKTQIEKMRLDYQHEIENLQNQQDS--ERAAHAKEMEALR----AKLMKVIKEKEN 697
+ + EK + D E+E L+ + + + A +E+ R A+L K ++E+
Sbjct: 1133 S----RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK 1188
Query: 698 SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757
+ EA ++ +H +E+ +L++A+ LE N+Q DN
Sbjct: 1189 NHEA---QIQDMRQRHATALEELSEQLEQAKRFKANLEK-----NKQGLETDN------- 1233
Query: 758 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 817
+E ++ L++ +E + + KKL Q++ E +A+ S+ + EL +
Sbjct: 1234 -KELACEVKVLQQVKAESEHKRKKLDAQVQ-----------ELHAKVSEGDRLRVELAEK 1281
Query: 818 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877
KL N +N+S TL +E + KFA ++A S++ +Q+T L ++ Q
Sbjct: 1282 ASKLQNELDNVS-------TLLEEAEKKGIKFA---KDAASLESQLQDTQELLQEETRQK 1331
Query: 878 NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN 937
LSS + +L E ++ + E++E + L K L++ +A+ K D+ + +
Sbjct: 1332 LNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE 1391
Query: 938 DELRLKERDVEELQLKL-------TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEK 990
+ + +D E L +L K + + LQ+ ++D+TV + Q++ A E+++
Sbjct: 1392 EAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH-QRQVASNLEKKQ 1450
Query: 991 KELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGA 1050
K+ ++ L++ EK + + E + R E E +TK + + L++ L E+
Sbjct: 1451 KKFDQLLAE-EKSISARY---AEERDRAEAEAREKETKALSLARALEEALEAKEE----F 1502
Query: 1051 REENSGLLQELEELRKQADK-AKAAQTAEDAMQIMEQMTKEKTETLASLED----TKQTN 1105
+N L ++E+L D K E + + +EQ +E L LED T+
Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 1106 AKLQNELDTLK---ENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ--- 1159
+L+ + +K E +L+ +E N+ K+ L ++ + E E E ++A A S+
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKM 1622
Query: 1160 ---------QLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI 1210
Q+ A + ++ ++L + + ++ +Q+ EE +++ K K +
Sbjct: 1623 EIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKL 1682
Query: 1211 KDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKV 1270
K + E LQ+ ++ + + E ++L +E+T +AS KS L +K
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEIT----NSASGKS------ALLDEKR 1732
Query: 1271 KLELKVKNLELQLKE---NKRQLSSSSGNTDTQAD---EDERAQESQIDFLNSVIVDLQR 1324
+LE ++ LE +L+E N L+ T Q D + A+ S ++ L+R
Sbjct: 1733 RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLER 1792
Query: 1325 KNQDLKMKVEMMSEA 1339
+N++LK K++ + A
Sbjct: 1793 QNKELKAKLQELEGA 1807
Score = 170 bits (431), Expect = 8e-42
Identities = 229/1111 (20%), Positives = 479/1111 (43%), Gaps = 119/1111 (10%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
+ T L E AR + L+E L + + +E+ + + E K +H+ ++E+
Sbjct: 898 AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 391 ELALARDGHDQHVLE---LEAKMDQLRTMVEAAD-------REK-------VELLNQLEE 433
+L + LE EAK+ ++ + + +EK E +QL E
Sbjct: 958 QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Query: 434 EKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVA 493
E+ K ++L ++ + DLE + K E +ELE++ K K D +L+D ++A
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA----KRKLDGETTDLQD-QIA 1072
Query: 494 TVSEKSRIMELEKDLALRVQEV--AELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE-- 549
+ +++I EL+ LA + +E+ A R E+ + + L +I+ LQE E
Sbjct: 1073 EL--QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 550 -VTRTDHQREITSLKEHFGAREETHQKEIKALYTATE---KLSKENESLKSKLEHANKEN 605
+R +++ L E A + + + E K +E LK LE K +
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190
Query: 606 SDVIALWKSKLETAIASHQQAMEELK------VSFSKGLGTETAEFAELKTQIEKMRLDY 659
I + + TA+ + +E+ K +GL T+ E A +++++ +
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 660 QHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMED 719
+H+ + L + Q E A E + LR +L + + +N L+ + + L++AE + + +D
Sbjct: 1251 EHKRKKL-DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD 1309
Query: 720 TLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEM 779
A +L+ Q E+T+ N +S+++ EE + ++L++ E +
Sbjct: 1310 -------AASLESQLQDTQELLQEETRQKLNLSSRIRQLEE---EKNSLQEQQEEEEEAR 1359
Query: 780 KKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLE 839
K L +Q+ A + Q+ + +K + + L+ + KL E LS+ + K
Sbjct: 1360 KNLEKQVLALQSQL--ADTKKKVDDDLGT--IESLEEAKKKLLKDAEALSQRLEEKALAY 1415
Query: 840 KELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD----ME 895
+L+ K + + ++ ++ + L +K+++F+ L ++ + + A+ E
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 896 AKFREKDERE-------EQLIKAKEKLEN-------DIAEIMKMSGDNSSQLTKMNDELR 941
A+ REK+ + E+ ++AKE+ E D+ ++M D + ++ R
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 942 LKERDVEELQLKL------TKANENASF-LQKSIEDMTVKAEQSQQEAAKKHEEEKKELE 994
E+ VEE++ +L +A E+A L+ +++ M + E+ Q +++EE+K+ L
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 995 RKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREEN 1054
+++ +LE ++E Q A ++ + K +I + K + +L+ + +
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI-EAANKARDEVIKQLRKLQAQM 1654
Query: 1055 SGLLQELEELRKQADKAKA-AQTAEDAMQIMEQMTKEKTETLASLE----DTKQTNAKLQ 1109
+ELEE R D+ A ++ +E ++ +E + E LAS E +Q +L
Sbjct: 1655 KDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 1110 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENV 1169
+E+ ++E + + + +++EE + +E L + + Q+ L N
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTL---NA 1771
Query: 1170 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSA 1229
+LA E ++ + Q+LE + L +L E++ K+ + +IS A
Sbjct: 1772 ELAAERSAAQKSDNARQQLERQNKELKAKLQELE----------GAVKSKFKATISALEA 1821
Query: 1230 LLTEKDAELE-KLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLE---LQLKE 1285
+ + + +LE + + + + K L + +E ++ + + +E ++K+
Sbjct: 1822 KIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQ 1881
Query: 1286 NKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEM---------- 1335
KRQL + T+A+ R + ++D L R+ LK ++
Sbjct: 1882 LKRQLEEAEEEA-TRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSR 1940
Query: 1336 -------MSEAALNGNGDDLNNYDSDDQEKQ 1359
+ A+L + DD + SD E Q
Sbjct: 1941 SGRRQLHLEGASLELSDDDTESKTSDVNETQ 1971
Score = 137 bits (345), Expect = 7e-32
Identities = 144/680 (21%), Positives = 321/680 (47%), Gaps = 70/680 (10%)
Query: 710 EDQHLVEMEDTLNKLQEAEIKVK-ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDAL 768
+++ L ++ L K++E + KV+ ELE ++ K + + + QL+A E + + +
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 769 RKASSEGKSEMKKLRQQLEAA----EKQIKHLEIEKNAESSKASSITRELQGRELKLTNL 824
R + K E++++ LE+ E++ + L+ EK + + +L E L
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKL 969
Query: 825 Q-ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD 883
Q E ++ +++K+ +E+E+ +L+++ ++ +E ++ + E ++L ++EE+ L+
Sbjct: 970 QLEKVTAEAKIKK-MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1028
Query: 884 LEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 943
K ++D+E + +++++ ++L KAK KL+ + ++ + +Q+ ++ +L K
Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1088
Query: 944 ERDVEELQLKLTKANE------NASFLQKSIEDMTVKAE---QSQQEAAKKHEEEKKELE 994
E EELQ L + ++ NA + + ++ + + +S++ + K E++K++L
Sbjct: 1089 E---EELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 995 RKL----SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGA 1050
+L ++LE ++T+ Q QEL+ + E+ +E K EE +N + + D + A
Sbjct: 1146 EELEALKTELEDTLDTTAAQ-QELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204
Query: 1051 REENSGLLQELEELRKQADKAKAAQTAED-----AMQIMEQMTKEKTETLASLE------ 1099
EE S L++ + + +K K ++ +++++Q+ E L+
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264
Query: 1100 ------------DTKQTNAKLQNELD---TLKENNLKNVEELNKSKELLTVENQKMEEFR 1144
+ + +KLQNELD TL E K + + +K+ ++E+Q +++ +
Sbjct: 1265 HAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK--KGIKFAKDAASLESQ-LQDTQ 1321
Query: 1145 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1204
+ ++ + S ++ L+EE L E+ +E + + LE++ L +QL + KK
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQEQ---QEEEEEARKNLEKQVLALQSQLADTKK 1378
Query: 1205 R---ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE----NASAKS 1257
+ + I+ +E K L K S L EK +KL L+ E
Sbjct: 1379 KVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438
Query: 1258 LHSVVQTLESDKVKLE---LKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDF 1314
V LE + K + + K++ + E + + + + +T+A RA E ++
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 1315 LNSVIVDLQRKNQDLKMKVE 1334
+ +R+N+ L+ +E
Sbjct: 1499 KE----EFERQNKQLRADME 1514
Score = 125 bits (315), Expect = 2e-28
Identities = 146/579 (25%), Positives = 256/579 (44%), Gaps = 62/579 (10%)
Query: 792 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 851
Q+ E E A+ + + + E +L ++ ++ + K L ++LQ E FAE
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 852 ASEEAVSVQRSMQETVNKLH-------QKEEQFNMLSSDLEKLRENLADMEAKFREKDER 904
A E + QE LH ++EE+ +L ++ +K++ ++ D+E + E++
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 905 EEQL----IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
++L + A+ K++ EI+ + NS K E +L E + E +L + E
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNS----KFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
A L K I + +E KK E+ ++ELE+ L+ + +Q EL+A+ +
Sbjct: 1022 AKNLAK-IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080
Query: 1021 ATSETKTKHEEILQNLQK---TLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTA 1077
+ K EE+ L + L + LK RE + + + E+ +++KA +
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDF--ESEKASRNKAE 1138
Query: 1078 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL----KNVEELNKSKELL 1133
+ + E++ KTE LEDT T A Q EL T +E + K +EE K+ E
Sbjct: 1139 KQKRDLSEELEALKTE----LEDTLDTTA-AQQELRTKREQEVAELKKALEEETKNHEAQ 1193
Query: 1134 TVENQK-----MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL 1188
+ ++ +EE +++E K+ A + L+ +N +LA E+ +V K
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV-----KVLQQVKA 1248
Query: 1189 EEE--RSVLNNQLLEM--KKRESKFIKDADEEKAS-LQKSISITSALLTEKDAELEKLRN 1243
E E R L+ Q+ E+ K E ++ EKAS LQ + S LL E + + K
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK 1308
Query: 1244 EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADE 1303
+ A SL S +Q D +L + +L L RQL + Q +E
Sbjct: 1309 D----------AASLESQLQ----DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 1304 DERAQ---ESQIDFLNSVIVDLQRKNQDLKMKVEMMSEA 1339
+E A+ E Q+ L S + D ++K D +E + EA
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA 1393
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 190 bits (483), Expect = 7e-48
Identities = 237/1014 (23%), Positives = 475/1014 (46%), Gaps = 113/1014 (11%)
Query: 291 AKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGT 350
A+ A +R + + LK+ L+ ++ V + ++ LTE + I+
Sbjct: 938 AELTAKKRKLEDECSELKKDIDDLELT-LAKVEKEKHATENKVKNLTEEMAGLDETIAKL 996
Query: 351 TALQEALKEK-QQHIEQLLAERD----LERAEVA---KATSHVGEIEQELALARD-GHDQ 401
T ++AL+E QQ ++ L AE D L +A++ + G +EQE + D +
Sbjct: 997 TKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAK 1056
Query: 402 HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKL 461
LE + K+ Q TM + +K +L +L++++ ++ LQ ++E+E L+ + K
Sbjct: 1057 RKLEGDLKLAQESTM--DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKE 1114
Query: 462 EHARIKELEQSLLFEKTKADKLQRELED--TRVATVSEK--------SRIMELEKDLALR 511
ARI+ELE+ + E+ K +++ D + +SE+ S +E+ K R
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK---R 1171
Query: 512 VQEVAELRRRLES-------------NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQRE 558
E ++RR LE K A V + + +++KLE +++ + E
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKME 1231
Query: 559 ITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 618
I L + ET K L L + +K+K E + +D+ A +++L+T
Sbjct: 1232 IDDLASNM----ETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTA-QRARLQT 1286
Query: 619 AIASHQQAMEE---LKVSFSKGLGTETAEFAELKTQIE---KMRLDYQHEIENLQNQQDS 672
+ + ++E L S+G T + ELK Q+E K + H +++ ++ D
Sbjct: 1287 ESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDL 1346
Query: 673 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL-QEAEIKV 731
R + +E EA +A+L + + + + + R+K + Q E+E+ KL Q +
Sbjct: 1347 LREQYEEEQEA-KAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405
Query: 732 KELEVLQAKCN--EQTK-----VIDNFTSQLKATEEKLLDLDALR----KASSEGKSEMK 780
+ +E + AKC E+TK +++ ++ T LD + K +E K + +
Sbjct: 1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCE 1465
Query: 781 KLRQQLEAAEKQIKHLEIE----KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 836
+ +LEA++K+ + L E KNA + E RE K NLQ+ +S++++
Sbjct: 1466 ETHAELEASQKESRSLSTELFKIKNAYEESLDQL--ETLKRENK--NLQQEISDLTEQIA 1521
Query: 837 TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEA 896
K + L++ + +E +Q +++E L +E + + +L +++ ++++
Sbjct: 1522 EGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVK---SEVDR 1578
Query: 897 KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK---ERDVEELQLK 953
K EKDE +Q+ + N I + M +++ ND +RLK E D+ E++++
Sbjct: 1579 KIAEKDEEIDQMKR------NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQ 1632
Query: 954 LTKANENASFLQKSIED--MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC 1011
L AN A+ ++ + +K Q + A + +E+ KE +L+ +E++ +
Sbjct: 1633 LNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKE---QLAMVERRANLLQAEI 1689
Query: 1012 QELKARYERATSETKTKHEEILQNLQK---------TLLDTEDKLKGAREENSGLLQE-L 1061
+EL+A E+ K +E+L ++ +L++T+ KL+ + G +++ +
Sbjct: 1690 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDII 1749
Query: 1062 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK----QTNAKLQNELDTLKE 1117
+E R +KAK A T DA + E++ KE+ +T A LE K QT LQ+ LD ++
Sbjct: 1750 QEARNAEEKAKKAIT--DAAMMAEELKKEQ-DTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1806
Query: 1118 NNLKNVEELNKSKE--LLTVENQKMEEFRKEIETLK--QAAAQKSQQLSALQEEN----V 1169
LK ++ + E + +E + E ++ +E +K + +K ++L+ EE+ +
Sbjct: 1807 LALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNIL 1866
Query: 1170 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1223
+L + + + + +V S+++ EE +N L +R +++A EE+A + +S
Sbjct: 1867 RLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEA-EERADIAES 1919
Score = 158 bits (399), Expect = 4e-38
Identities = 224/1051 (21%), Positives = 439/1051 (41%), Gaps = 145/1051 (13%)
Query: 387 EIEQELALARDGHDQHVLEL---EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQF 443
E E+E+A ++ ++ EL EAK +L + +EK +L Q++ E + D +
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 444 RVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIME 503
R ++ TK LE + K E E E+ + E T +R+LED E S + +
Sbjct: 908 RCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELTAK---KRKLED-------ECSELKK 956
Query: 504 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 563
DL L + +V E + NK + L + I+ L ++ + + HQ+ + L
Sbjct: 957 DIDDLELTLAKV-EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL- 1014
Query: 564 EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA-- 621
+ + ++ L A KL ++ + L+ LE K D + K KLE +
Sbjct: 1015 -------QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMD-LERAKRKLEGDLKLA 1066
Query: 622 ---------SHQQAMEELKVS--FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 670
QQ E+LK GL ++ + L Q++K + Q IE L+ +
Sbjct: 1067 QESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEI 1126
Query: 671 DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 730
++ERA+ RAK K + LE I +L++A ++E +NK +EAE +
Sbjct: 1127 EAERAS--------RAKAEKQRSDLSRELEEISERLEEAGGATSAQIE--MNKKREAEFQ 1176
Query: 731 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD-------ALRKASSEGKSEMKKLR 783
++ +A + + E +D L K SE K E+ L
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1236
Query: 784 QQLEAAEKQIKHLEIEKNAESSKASSI-TRELQGREL------KLTNLQENLSEVSQ--- 833
+E K +LE A + S I T+E + + L + LQ E S+
Sbjct: 1237 SNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLD 1296
Query: 834 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 893
K+TL +L K+ F + EE ++R ++E + D + LRE
Sbjct: 1297 EKDTLVSQLSRGKQAFTQQIEE---LKRQLEEEIKAKSALAHALQSSRHDCDLLRE---- 1349
Query: 894 MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK--------ER 945
++ E+ E + +L +A K +++A+ ++ Q T+ +E + K E
Sbjct: 1350 ---QYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1406
Query: 946 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME 1005
VE + K + LQ +ED+ + E++ A L++K + +K +
Sbjct: 1407 HVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACA--------ALDKKQRNFDKILA 1458
Query: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
+C+E A E + E+++ E+ + ++ ++ D+L+ + EN L QE+ +L
Sbjct: 1459 EWKQKCEETHAELEASQKESRSLSTELFK-IKNAYEESLDQLETLKRENKNLQQEISDLT 1517
Query: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE- 1124
+Q A+ + + +I +Q+ +EK+E A+LE+ + A L++E E + ++
Sbjct: 1518 EQI--AEGGKRIHELEKIKKQVEQEKSELQAALEEAE---ASLEHE-----EGKILRIQL 1567
Query: 1125 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS 1184
ELN+ K + ++K+ E +EI+ +K+ + ++ L E+ D +
Sbjct: 1568 ELNQVKSEV---DRKIAEKDEEIDQMKR------NHIRIVESMQSTLDAEIRSRNDAIRL 1618
Query: 1185 HQKLEEERSVLNNQLLEMKKRESKFIK------------------------DADEEKASL 1220
+K+E + + + QL + ++ ++ D E+ A +
Sbjct: 1619 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV 1678
Query: 1221 QKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS----LHSVVQTLESDKVKLELKV 1276
++ ++ A + E A LE+ + E A LH+ +L + K KLE +
Sbjct: 1679 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1738
Query: 1277 KNLE------LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLK 1330
++ +Q N + + + E+ + ++ L + +L++ +DL+
Sbjct: 1739 SQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ 1798
Query: 1331 MKVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1361
+++ + AL G + ++ +E + +
Sbjct: 1799 HRLDEAEQLALKGGKKQIQKLEARVRELEGE 1829
Score = 149 bits (376), Expect = 2e-35
Identities = 235/1127 (20%), Positives = 484/1127 (42%), Gaps = 197/1127 (17%)
Query: 357 LKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL--- 413
+KE+ + ++ LA+ + +R E+ + + + + +L L + + E + DQL
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKT 915
Query: 414 RTMVEAADREKVELLNQLEE-------EKRKVED----LQFRVEEESITKGDLETQTKLE 462
+ +EA +E E EE +KRK+ED L+ +++ +T +E +
Sbjct: 916 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 975
Query: 463 HARIKELEQSL------LFEKTKADKLQRE----------LEDTRVATVSE-KSRIMELE 505
++K L + + + + TK K +E E+ +V T+++ K ++ +
Sbjct: 976 ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQV 1035
Query: 506 KDLALRVQEVAELRRRLE--SNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 563
DL +++ ++R LE K GD+ ++ +I + +++L+ + E++ L+
Sbjct: 1036 DDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQ 1095
Query: 564 ---EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAI 620
E A QK+IK L E+L +E E+ ++ A K+ SD+
Sbjct: 1096 SKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL------------ 1143
Query: 621 ASHQQAMEELKVSFSKGLGTETAEF---AELKTQIEKMRLDYQHEIENLQNQQDSERAAH 677
+ +EE+ + G +A+ + + + +KMR D E LQ++ A
Sbjct: 1144 ---SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL--EEATLQHE------AT 1192
Query: 678 AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL------------- 724
A + A + + E+ ++L+ ++ KL+K + + +E++D + +
Sbjct: 1193 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKM 1252
Query: 725 ------QEAEIKVKELEV-------------LQAKCNEQTKVIDN--------------F 751
Q +EIK KE E LQ + E ++ +D F
Sbjct: 1253 CRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAF 1312
Query: 752 TSQL----KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 807
T Q+ + EE++ AL A + + LR+Q E E+Q E+++ SKA
Sbjct: 1313 TQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYE--EEQEAKAELQR--AMSKA 1368
Query: 808 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 867
+S Q R T+ + E+ + K+ L + LQ +E + + S++++ Q
Sbjct: 1369 NS--EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQ 1426
Query: 868 NKLHQ---KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA-EIM 923
N++ E+ N + L+K + N + A++++K E ++A +K ++ E+
Sbjct: 1427 NEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELF 1486
Query: 924 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 983
K+ L D+L +R+ + LQ +++ E + K I ++ ++
Sbjct: 1487 KIKNAYEESL----DQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL--------EKIK 1534
Query: 984 KKHEEEKKELERKLSDLEKKMETSHN-------QCQELKARYERATSE-------TKTKH 1029
K+ E+EK EL+ L + E +E + ++K+ +R +E K H
Sbjct: 1535 KQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNH 1594
Query: 1030 EEILQNLQKTLLDTEDKLKG----AREENSGLLQELEELRKQADK--AKAAQTAEDAMQI 1083
I++++Q T LD E + + +++ G L E+E A++ A+A + + I
Sbjct: 1595 IRIVESMQST-LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAI 1653
Query: 1084 MEQMTKEKTETLASLEDTKQTNAK-------LQNELDTLK------ENNLKNVE----EL 1126
++ + L S ED K+ A LQ E++ L+ E + K E +
Sbjct: 1654 LKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1713
Query: 1127 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRS--RDEVTS 1184
++ +LL +N + +K++ET + + + +QE + AEE + D
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLET--DISQIQGEMEDIIQE--ARNAEEKAKKAITDAAMM 1769
Query: 1185 HQKLEEERSVLNNQLLEMKKRESKFIKDA-----DEEKASL---QKSISITSALLTEKDA 1236
++L++E+ + L MKK + +KD + E+ +L +K I A + E +
Sbjct: 1770 AEELKKEQDT-SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEG 1828
Query: 1237 ELE-KLRNEVTVLRGENASAKSLHSVVQTLESDK---VKLELKVKNLELQLKENKRQLSS 1292
E+E + + V ++G + + + E D+ ++L+ V L+ ++K KRQ
Sbjct: 1829 EVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1888
Query: 1293 SSGNTDTQADEDERAQ------ESQIDFLNSVIVDLQRKNQDLKMKV 1333
+ ++ + R Q E + D S + L+ K++++ K+
Sbjct: 1889 AEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935
Score = 148 bits (373), Expect = 4e-35
Identities = 166/785 (21%), Positives = 345/785 (43%), Gaps = 99/785 (12%)
Query: 631 KVSFSKGL-----GTETAEFAELKTQIEKM------RLDYQHEIENLQN----QQDSERA 675
KV F GL + A+L T+ + M R++YQ +E ++ Q +
Sbjct: 766 KVFFKAGLLGLLEEMRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAF 825
Query: 676 AHAKEMEALRA--KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 733
+ K ++ K+ ++K E E K E E T +L + E K KE
Sbjct: 826 MNVKHWPWMKLYFKIKPLLKSAETEKEMANMK---------EEFEKTKEELAKTEAKRKE 876
Query: 734 LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL----DALRKASSEGKSEMKKLRQQLEAA 789
LE ++ ++ Q++A + L D D L K + ++++K++ ++ E
Sbjct: 877 LEEKMVTLMQEK---NDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDE 933
Query: 790 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKF 849
E+ L +K + S + +++ EL L +++ + L +E+ L E
Sbjct: 934 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI 993
Query: 850 AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI 909
A+ ++E ++Q + Q+T++ L +E++ N L+ KL + + D+E ++ + L
Sbjct: 994 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLE 1053
Query: 910 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE 969
+AK KLE D+ + + D + +++++L+ KE ++ LQ K+ LQK I+
Sbjct: 1054 RAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIK 1113
Query: 970 DMTVKAEQSQQE------AAKKHEEEKKELERKLSDLEKKMETS---------HNQCQEL 1014
++ + E+ ++E + K E+++ +L R+L ++ +++E + N+ +E
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1173
Query: 1015 K-ARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA----- 1068
+ + R E +HE L+K D+ +L + + Q+LE+ + +
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1233
Query: 1069 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT----LKENNLKNVE 1124
D A +T A +E+M + + L+ ++ ++ +L N+L L+ + +
Sbjct: 1234 DLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSR 1293
Query: 1125 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSAL-------------------- 1164
+L++ L++ ++ + F ++IE LK+ ++ + SAL
Sbjct: 1294 QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEE 1353
Query: 1165 -QEENVKLAEELGRSRDEVTS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK 1222
QE +L + ++ EV K E + +L E KK+ ++ ++DA+E
Sbjct: 1354 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEH------ 1407
Query: 1223 SISITSALLTEKDAELEKLRNEVTVL----RGENASAKSLHSVVQTLESDKVKLELKVKN 1278
+ +A + ++L+NEV L NA+ +L + DK+ E K K
Sbjct: 1408 -VEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNF--DKILAEWKQKC 1464
Query: 1279 LELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
E + Q S S T+ + + A E +D L + L+R+N++L+ ++ ++E
Sbjct: 1465 EETHAELEASQKESRS--LSTELFKIKNAYEESLDQLET----LKRENKNLQQEISDLTE 1518
Query: 1339 AALNG 1343
G
Sbjct: 1519 QIAEG 1523
Score = 101 bits (252), Expect = 4e-21
Identities = 130/624 (20%), Positives = 265/624 (42%), Gaps = 58/624 (9%)
Query: 316 LSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLER 375
+ + S++A ++ S LL E +Y + LQ A+ + + Q R
Sbjct: 1327 IKAKSALAHALQSSRHDCDLLRE---QYEEEQEAKAELQRAMSKANSEVAQW---RTKYE 1380
Query: 376 AEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLE--- 432
+ + T + E +++LA ++HV + AK L + E +L+ +E
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTN 1440
Query: 433 ------------------EEKRKVEDLQFRVEEESITKGDLETQT-KLEHARIKELEQSL 473
E K+K E+ +E L T+ K+++A + L+Q L
Sbjct: 1441 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ-L 1499
Query: 474 LFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDM 533
K + LQ+E+ D RI ELEK QE +EL+ LE + + + +
Sbjct: 1500 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEE 1559
Query: 534 SLSLLQEISSLQEKLEVTR--TDHQREITSLKEHF----GAREETHQKEIKALYTAT--- 584
L ++ Q K EV R + EI +K + + + T EI++ A
Sbjct: 1560 GKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1619
Query: 585 EKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAE 644
+K+ + ++ +L HAN+ ++ + +++ Q +++ ++ L ++ +
Sbjct: 1620 KKMEGDLNEMEIQLNHANRMAAEALRNYRNT--------QAILKDTQLHLDDALRSQE-D 1670
Query: 645 FAELKTQIEKMRLDYQHEIENLQ-NQQDSERAAHAKEMEALRA-KLMKVIKEKENSLEAI 702
E +E+ Q EIE L+ + +ER+ E E L A + ++++ + SL
Sbjct: 1671 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1730
Query: 703 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKL 762
+ KL+ Q EMED + + + AE K K+ A E+ K + ++ L+ ++ L
Sbjct: 1731 KKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790
Query: 763 LDL--DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELK 820
D + + +K ++Q++ E +++ LE E +E + + L+ E K
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERK 1850
Query: 821 LTNL-------QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 873
+ L ++N+ + + + L+ +++ K + EA E++ + ++L +
Sbjct: 1851 VKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEA 1910
Query: 874 EEQFNMLSSDLEKLRENLADMEAK 897
EE+ ++ S + KLR ++ K
Sbjct: 1911 EERADIAESQVNKLRVKSREVHTK 1934
Score = 31.6 bits (70), Expect = 5.7
Identities = 30/136 (22%), Positives = 61/136 (44%), Gaps = 10/136 (7%)
Query: 352 ALQEALKEKQQHIEQLLAE-RDLERAEVAKATSHVGEIE---------QELALARDGHDQ 401
A Q ALK ++ I++L A R+LE ++ +V ++ +EL + +
Sbjct: 1804 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRK 1863
Query: 402 HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKL 461
++L L+ +D+L+ V++ R+ E Q K +Q +EE E+Q
Sbjct: 1864 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNK 1923
Query: 462 EHARIKELEQSLLFEK 477
+ +E+ ++ E+
Sbjct: 1924 LRVKSREVHTKIISEE 1939
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 188 bits (477), Expect = 4e-47
Identities = 234/1016 (23%), Positives = 468/1016 (46%), Gaps = 117/1016 (11%)
Query: 291 AKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGT 350
A+ A +R + + LK+ L+ ++ V + ++ LTE + I+
Sbjct: 940 AELTAKKRKLEDECSELKKDIDDLELT-LAKVEKEKHATENKVKNLTEEMAGLDETIAKL 998
Query: 351 TALQEALKEK-QQHIEQLLAERD----LERAEVA---KATSHVGEIEQELALARDGHDQH 402
T ++AL+E QQ ++ L AE D L +A++ + G +EQE L D ++
Sbjct: 999 TKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMD-LERA 1057
Query: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLE 462
+LE + + + + EK +L +L++++ ++ +LQ ++E+E L+ + K
Sbjct: 1058 KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKEL 1117
Query: 463 HARIKELEQSLLFEKTKADKLQRELED--TRVATVSEK--------SRIMELEKDLALRV 512
ARI+ELE+ + E+ K +++ D + +SE+ S +E+ K R
Sbjct: 1118 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK---RE 1174
Query: 513 QEVAELRRRLES-------------NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREI 559
E ++RR LE K A V + + +++KLE +++ + EI
Sbjct: 1175 AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI 1234
Query: 560 TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETA 619
L + ET K L L + LKSK E + +D+ A + +L+T
Sbjct: 1235 DDL----ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA-QRGRLQTE 1289
Query: 620 IASHQQAMEE---LKVSFSKGLGTETAEFAELKTQIE---KMRLDYQHEIENLQNQQDSE 673
+ ++E L S+G T + ELK Q+E K + H +++ ++ D
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL 1349
Query: 674 RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL-QEAEIKVK 732
R + +E E+ +A+L + + + + R+K + Q E+E+ KL Q + +
Sbjct: 1350 REQYEEEQES-KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Query: 733 ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR--------------KASSEGKSE 778
+E + AKC K +++ E+ +LD++ K +E K +
Sbjct: 1409 HVEAVNAKCASLEKTKQRLQNEV---EDLMLDVERTNAACAALDKKQRNFDKILAEWKQK 1465
Query: 779 MKKLRQQLEAAEKQIKHLEIE----KNAESSKASSITRELQGRELKLTNLQENLSEVSQV 834
++ +LEA++K+ + L E KNA + E RE K NLQ+ +S++++
Sbjct: 1466 CEETHAELEASQKEARSLGTELFKIKNAYEESLDQL--ETLKRENK--NLQQEISDLTEQ 1521
Query: 835 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADM 894
K + L++ + +E +Q +++E L +E + + +L +++ +++
Sbjct: 1522 IAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVK---SEV 1578
Query: 895 EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK---ERDVEELQ 951
+ K EKDE +QL + N I + M +++ ND +RLK E D+ E++
Sbjct: 1579 DRKIAEKDEEIDQLKR------NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 952 LKLTKANENASFLQKSIEDM--TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN 1009
++L AN A+ ++ + +K Q + A + +E+ KE +L+ +E++
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE---QLAMVERRANLLQA 1689
Query: 1010 QCQELKARYERATSETKTKHEEILQNLQK---------TLLDTEDKLKGAREENSGLLQE 1060
+ +EL+A E+ K +E+L ++ +L++T+ KL+ + G +++
Sbjct: 1690 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMED 1749
Query: 1061 -LEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK----QTNAKLQNELDTL 1115
L+E R +KAK A T DA + E++ KE+ +T A LE K QT LQ LD
Sbjct: 1750 ILQEARNAEEKAKKAIT--DAAMMAEELKKEQ-DTSAHLERMKKNMEQTVKDLQLRLDEA 1806
Query: 1116 KENNLKNVEELNKSKE--LLTVENQKMEEFRKEIETLK--QAAAQKSQQLSALQEEN--- 1168
++ LK ++ + E + +E + E ++ E +K + ++ ++L+ EE+
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866
Query: 1169 -VKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1223
++L + + + + +V S+++ EE +N L ++ +++A EE+A + +S
Sbjct: 1867 ILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA-EERADIAES 1921
Score = 157 bits (398), Expect = 5e-38
Identities = 239/1124 (21%), Positives = 488/1124 (43%), Gaps = 169/1124 (15%)
Query: 346 KISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLE 405
K + T +KE+ Q I+ LA+ + +R E+ + + + + +L L + + +
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906
Query: 406 LEAKMDQL---RTMVEAADREKVELLNQLEE-------EKRKVED----LQFRVEEESIT 451
E + DQL + +EA +E E EE +KRK+ED L+ +++ +T
Sbjct: 907 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 966
Query: 452 KGDLETQTKLEHARIKELEQSL------LFEKTKADKLQRE----------LEDTRVATV 495
+E + ++K L + + + + TK K +E E+ +V T+
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
Query: 496 SE-KSRIMELEKDLALRVQEVAELRRRLE--SNKPAGDVDMSLSLLQEISSLQEKLEVTR 552
++ K ++ + DL +++ +LR LE K GD+ ++ + +I + +++L+
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086
Query: 553 TDHQREITSLK-----------------EHFGAREETHQKEIKALYTATEK-------LS 588
+ EI++L+ + AR E ++EI+A + K LS
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 589 KENESLKSKLEHANKENSDVIALWKSK----------LETAIASHQQAMEELKVSFSKG- 637
+E E + +LE A S I + K + LE A H+ L+ +
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 638 --LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 695
LG + +K ++EK + + + EI++L A++ + + + L K+ +
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDL--------ASNVETVSKAKGNLEKMCRTL 1258
Query: 696 ENSLEAIRSKLDKAEDQHLV-EMEDTLNKLQ-EAEIKVKELEVLQAKCNEQTKVIDNFTS 753
E+ L ++SK + E Q L+ ++ +LQ E+ ++L+ +A ++ ++ FT
Sbjct: 1259 EDQLSELKSK--EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316
Query: 754 QL----KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASS 809
Q+ + EE++ +AL A + + LR+Q E E+Q E+++ SKA+
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYE--EEQESKAELQR--ALSKAN- 1371
Query: 810 ITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRS---MQET 866
T Q R T+ + E+ + K+ L + LQ +E + + S++++ +Q
Sbjct: 1372 -TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNE 1430
Query: 867 VNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDI-AEIMKM 925
V L E+ N + L+K + N + A++++K E ++A +K + E+ K+
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKI 1490
Query: 926 SGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 985
L D+L +R+ + LQ +++ E + K I ++ ++ K+
Sbjct: 1491 KNAYEESL----DQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL--------EKIKKQ 1538
Query: 986 HEEEKKELERKLSDLEKKMETSHN-------QCQELKARYERATSE-------TKTKHEE 1031
E+EK EL+ L + E +E + ++K+ +R +E K H
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Query: 1032 ILQNLQKTLLDTEDKLKG----AREENSGLLQELEELRKQADK--AKAAQTAEDAMQIME 1085
I++++Q T LD E + + +++ G L E+E A++ A+A + + I++
Sbjct: 1599 IVESMQST-LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 1086 QMTKEKTETLASLEDTKQTNAK-------LQNELDTLK------ENNLKNVE----ELNK 1128
+ L S ED K+ A LQ E++ L+ E + K E + ++
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717
Query: 1129 SKELLTVENQKMEEFRKEIET-----------LKQAAAQKSQQLSALQEENVKLAEELGR 1177
+LL +N + +K++ET + Q A ++ + +AEEL +
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 1178 SRDEVTSHQKLEE--ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKD 1235
+D +++++ E++V + Q L + + E +K K +QK + L E +
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQ-LRLDEAEQLALKGG---KKQIQKLEARVRELEGEVE 1833
Query: 1236 AELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSG 1295
+E ++ V LR K L + + ++L+ V L+ ++K KRQ +
Sbjct: 1834 SEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1893
Query: 1296 NTDTQADEDERAQ------ESQIDFLNSVIVDLQRKNQDLKMKV 1333
++T + + Q E + D S + L+ K++++ KV
Sbjct: 1894 QSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937
Score = 157 bits (397), Expect = 7e-38
Identities = 222/1051 (21%), Positives = 437/1051 (41%), Gaps = 145/1051 (13%)
Query: 387 EIEQELALARDGHDQHVLEL---EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQF 443
E E+E+A ++ + EL EAK +L + +EK +L Q++ E + D +
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 444 RVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIME 503
R ++ TK LE + K E E E+ + E T +R+LED E S + +
Sbjct: 910 RCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELTAK---KRKLED-------ECSELKK 958
Query: 504 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 563
DL L + +V E + NK + L + I+ L ++ + + HQ+ + L
Sbjct: 959 DIDDLELTLAKV-EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL- 1016
Query: 564 EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASH 623
+ + ++ L A KL ++ + L+ LE K D + K KLE +
Sbjct: 1017 -------QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMD-LERAKRKLEGDLKLA 1068
Query: 624 QQA---MEELKVSFSKGLGTETAEFAELKTQIE----------KMRLDYQHEIENLQNQQ 670
Q++ +E K + L + E + L+++IE K + Q IE L+ +
Sbjct: 1069 QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 671 DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 730
++ERA+ RAK K + LE I +L++A ++E +NK +EAE +
Sbjct: 1129 EAERAS--------RAKAEKQRSDLSRELEEISERLEEAGGATSAQIE--MNKKREAEFQ 1178
Query: 731 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD-------ALRKASSEGKSEMKKLR 783
++ +A + + E +D L K SE K E+ L
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 784 QQLEAA-------EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ--- 833
+E EK + LE + + SK R + + LQ E S+
Sbjct: 1239 SNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298
Query: 834 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 893
KE L +L K+ F + EE ++R ++E + + N L+ L+ R +
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEE---LKRQLEEEI-------KAKNALAHALQSSRHDCDL 1348
Query: 894 MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLT--------KMNDELRLKER 945
+ ++ E+ E + +L +A K ++A+ ++ Q T K+ L+ E
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Query: 946 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME 1005
VE + K + LQ +ED+ + E++ A L++K + +K +
Sbjct: 1409 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACA--------ALDKKQRNFDKILA 1460
Query: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
+C+E A E + E ++ E+ + ++ ++ D+L+ + EN L QE+ +L
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFK-IKNAYEESLDQLETLKRENKNLQQEISDLT 1519
Query: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE- 1124
+Q A+ + + +I +Q+ +EK E A+LE+ + A L++E E + ++
Sbjct: 1520 EQI--AEGGKRIHELEKIKKQVEQEKCELQAALEEAE---ASLEHE-----EGKILRIQL 1569
Query: 1125 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS 1184
ELN+ K + ++K+ E +EI+ LK+ + ++ L E+ D +
Sbjct: 1570 ELNQVKSEV---DRKIAEKDEEIDQLKR------NHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 1185 HQKLEEERSVLNNQLLEMKKRESKFIK------------------------DADEEKASL 1220
+K+E + + + QL + ++ ++ D E+ A +
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680
Query: 1221 QKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS----LHSVVQTLESDKVKLELKV 1276
++ ++ A + E A LE+ + E A LH+ +L + K KLE +
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 1277 KNLE------LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLK 1330
++ LQ N + + + E+ + ++ L + ++++ +DL+
Sbjct: 1741 SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQ 1800
Query: 1331 MKVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1361
++++ + AL G + ++ +E + +
Sbjct: 1801 LRLDEAEQLALKGGKKQIQKLEARVRELEGE 1831
Score = 143 bits (361), Expect = 1e-33
Identities = 154/752 (20%), Positives = 337/752 (44%), Gaps = 94/752 (12%)
Query: 656 RLDYQHEIENLQ-------NQQDSERAAHAKEMEALRAKLMKVIK--EKENSLEAIRSKL 706
R++YQ +E + N + H M+ L K+ ++K E E + ++ +
Sbjct: 804 RVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMK-LFFKIKPLLKSAETEKEMATMKEEF 862
Query: 707 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL- 765
K +D+ L ++E K KELE K K ++ Q++A E L D
Sbjct: 863 QKIKDE-----------LAKSEAKRKELE---EKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 766 ---DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLT 822
D L K + ++++K++ ++ E E+ L +K + S + +++ EL L
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 823 NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS 882
+++ + L +E+ L E A+ ++E ++Q + Q+T++ L +E++ N L+
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028
Query: 883 DLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 942
KL + + D+E ++ + L +AK KLE D+ + D ++ +++++L+
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088
Query: 943 KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE------AAKKHEEEKKELERK 996
KE ++ LQ K+ LQK I+++ + E+ ++E + K E+++ +L R+
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1148
Query: 997 LSDLEKKMETS---------HNQCQELK-ARYERATSETKTKHEEILQNLQKTLLDTEDK 1046
L ++ +++E + N+ +E + + R E +HE L+K D+ +
Sbjct: 1149 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE 1208
Query: 1047 LKGAREENSGLLQELEELRKQA-----DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDT 1101
L + + Q+LE+ + + D A +T A +E+M + + L+ L+
Sbjct: 1209 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Query: 1102 KQTNAKLQNELDT----LKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1157
++ +L N+L L+ + + +L++ + L++ ++ + F ++IE LK+ ++
Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328
Query: 1158 SQQLSAL---------------------QEENVKLAEELGRSRDEVTS-HQKLEEERSVL 1195
+ +AL QE +L L ++ EV K E +
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388
Query: 1196 NNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVL----RGE 1251
+L E KK+ ++ ++ A+E + +A + ++L+NEV L
Sbjct: 1389 TEELEEAKKKLAQRLQAAEEH-------VEAVNAKCASLEKTKQRLQNEVEDLMLDVERT 1441
Query: 1252 NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQ 1311
NA+ +L + + + + K + +L+ ++++ S T+ + + A E
Sbjct: 1442 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS----LGTELFKIKNAYEES 1497
Query: 1312 IDFLNSVIVDLQRKNQDLKMKVEMMSEAALNG 1343
+D L + L+R+N++L+ ++ ++E G
Sbjct: 1498 LDQLET----LKRENKNLQQEISDLTEQIAEG 1525
Score = 103 bits (257), Expect = 1e-21
Identities = 136/626 (21%), Positives = 271/626 (43%), Gaps = 62/626 (9%)
Query: 316 LSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLER 375
+ + +++A ++ S LL E +Y + LQ AL + + Q R
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLRE---QYEEEQESKAELQRALSKANTEVAQW---RTKYE 1382
Query: 376 AEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLE--- 432
+ + T + E +++LA ++HV + AK L + E +L+ +E
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 433 ------------------EEKRKVEDLQFRVEEESITKGDLETQT-KLEHARIKELEQSL 473
E K+K E+ +E L T+ K+++A + L+Q L
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ-L 1501
Query: 474 LFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDM 533
K + LQ+E+ D RI ELEK QE EL+ LE + + + +
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEE 1561
Query: 534 SLSLLQEISSLQEKLEVTR--TDHQREITSLKEHF----GAREETHQKEIKALYTAT--- 584
L ++ Q K EV R + EI LK + + + T EI++ A
Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1621
Query: 585 EKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAE 644
+K+ + ++ +L HAN+ ++ + +++ Q +++ ++ L ++ +
Sbjct: 1622 KKMEGDLNEMEIQLNHANRMAAEALRNYRNT--------QGILKDTQIHLDDALRSQE-D 1672
Query: 645 FAELKTQIEKMRLDYQHEIENLQ-NQQDSERAAHAKEMEALRA-KLMKVIKEKENSLEAI 702
E +E+ Q EIE L+ + +ER+ E E L A + ++++ + SL
Sbjct: 1673 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1732
Query: 703 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL----KAT 758
+ KL+ Q EMED L + + AE K K+ A E+ K + ++ L K
Sbjct: 1733 KKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1792
Query: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
E+ + DL LR +E + +K ++Q++ E +++ LE E +E + + + L+ E
Sbjct: 1793 EQTVKDLQ-LRLDEAE-QLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850
Query: 819 LKLTNL-------QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH 871
++ L ++N+ + + + L+ +++ K + EA E++ + ++ ++L
Sbjct: 1851 RRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELE 1910
Query: 872 QKEEQFNMLSSDLEKLRENLADMEAK 897
+ EE+ ++ S + KLR ++ K
Sbjct: 1911 EAEERADIAESQVNKLRVKSREVHTK 1936
Score = 97.4 bits (241), Expect = 8e-20
Identities = 159/689 (23%), Positives = 291/689 (42%), Gaps = 98/689 (14%)
Query: 326 VSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHV 385
++ ++ G L S ++R++ AL L +Q Q + E + E KA + +
Sbjct: 1276 INDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNAL 1335
Query: 386 GEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRV 445
AL HD D LR E K EL L + +V + +
Sbjct: 1336 AH-----ALQSSRHD---------CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381
Query: 446 EEESITKGD-LETQTKLEHARIKELEQSL--------LFEKTKADKLQRELED------- 489
E ++I + + LE K R++ E+ + EKTK +LQ E+ED
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK-QRLQNEVEDLMLDVER 1440
Query: 490 TRVATVSEKSRIMELEKDLALRVQEVAELRRRLE-SNKPAGDVDMSL----SLLQEISSL 544
T A + + +K LA Q+ E LE S K A + L + +E
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 545 QEKLEVTRTDHQREITSLKEHF---GAREETHQKEIKALYTATEKLSKENESLKSKLEHA 601
E L+ + Q+EI+ L E G R +K K + +L E ++ LEH
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEH- 1559
Query: 602 NKENSDVIALW------KSKLETAIASHQQAMEELKVSFSKGLGTETAEF-AELKTQIEK 654
E ++ + KS+++ IA + +++LK + + + + + AE++++ +
Sbjct: 1560 --EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDA 1617
Query: 655 MRLDYQHEIENLQNQQDSERAAHAKEMEALR--AKLMKVIKEKENSLE-AIRSKLDKAED 711
+RL + E +L + A+ EALR ++K+ + L+ A+RS+ D E
Sbjct: 1618 IRLKKKME-GDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ 1676
Query: 712 QHLVEMEDTLNKLQEAEI-----------KVKELEVLQAKCNEQTKVIDNFTSQLKATEE 760
+VE L + + E+ K+ E E+L A +E+ +++ + L T++
Sbjct: 1677 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA--SERVQLLHTQNTSLINTKK 1734
Query: 761 KLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH-------LEIEKNAESSKASSITRE 813
KL S+ + EM+ + Q+ AE++ K + E E ++ + R
Sbjct: 1735 KL------ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1788
Query: 814 LQGRELKLTNLQENLSEVSQVK-ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 872
+ E + +LQ L E Q+ + +K++Q L+ + E E S Q+ E V L +
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK 1848
Query: 873 KEEQFNMLSSDLEKLRENL-----------ADMEAKFREKDEREEQL---IKAKEKLEND 918
E + L+ E+ R+N+ A +++ R+ +E EEQ + KL+++
Sbjct: 1849 HERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHE 1908
Query: 919 IAEIMKMSGDNSSQLTKMNDELRLKERDV 947
+ E + + SQ+ K LR+K R+V
Sbjct: 1909 LEEAEERADIAESQVNK----LRVKSREV 1933
Score = 33.9 bits (76), Expect = 1.2
Identities = 33/136 (24%), Positives = 58/136 (42%), Gaps = 10/136 (7%)
Query: 352 ALQEALKEKQQHIEQLLAE-RDLE---------RAEVAKATSHVGEIEQELALARDGHDQ 401
A Q ALK ++ I++L A R+LE AE K +EL + +
Sbjct: 1806 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1865
Query: 402 HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKL 461
++L L+ +D+L+ V++ R+ E Q K LQ +EE E+Q
Sbjct: 1866 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925
Query: 462 EHARIKELEQSLLFEK 477
+ +E+ ++ E+
Sbjct: 1926 LRVKSREVHTKVISEE 1941
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 188 bits (477), Expect = 4e-47
Identities = 234/1016 (23%), Positives = 468/1016 (46%), Gaps = 117/1016 (11%)
Query: 291 AKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGT 350
A+ A +R + + LK+ L+ ++ V + ++ LTE + I+
Sbjct: 940 AELTAKKRKLEDECSELKKDIDDLELT-LAKVEKEKHATENKVKNLTEEMAGLDETIAKL 998
Query: 351 TALQEALKEK-QQHIEQLLAERD----LERAEVA---KATSHVGEIEQELALARDGHDQH 402
T ++AL+E QQ ++ L AE D L +A++ + G +EQE L D ++
Sbjct: 999 TKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMD-LERA 1057
Query: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLE 462
+LE + + + + EK +L +L++++ ++ +LQ ++E+E L+ + K
Sbjct: 1058 KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKEL 1117
Query: 463 HARIKELEQSLLFEKTKADKLQRELED--TRVATVSEK--------SRIMELEKDLALRV 512
ARI+ELE+ + E+ K +++ D + +SE+ S +E+ K R
Sbjct: 1118 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK---RE 1174
Query: 513 QEVAELRRRLES-------------NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREI 559
E ++RR LE K A V + + +++KLE +++ + EI
Sbjct: 1175 AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI 1234
Query: 560 TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETA 619
L + ET K L L + LKSK E + +D+ A + +L+T
Sbjct: 1235 DDL----ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA-QRGRLQTE 1289
Query: 620 IASHQQAMEE---LKVSFSKGLGTETAEFAELKTQIE---KMRLDYQHEIENLQNQQDSE 673
+ ++E L S+G T + ELK Q+E K + H +++ ++ D
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL 1349
Query: 674 RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL-QEAEIKVK 732
R + +E E+ +A+L + + + + R+K + Q E+E+ KL Q + +
Sbjct: 1350 REQYEEEQES-KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Query: 733 ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR--------------KASSEGKSE 778
+E + AKC K +++ E+ +LD++ K +E K +
Sbjct: 1409 HVEAVNAKCASLEKTKQRLQNEV---EDLMLDVERTNAACAALDKKQRNFDKILAEWKQK 1465
Query: 779 MKKLRQQLEAAEKQIKHLEIE----KNAESSKASSITRELQGRELKLTNLQENLSEVSQV 834
++ +LEA++K+ + L E KNA + E RE K NLQ+ +S++++
Sbjct: 1466 CEETHAELEASQKEARSLGTELFKIKNAYEESLDQL--ETLKRENK--NLQQEISDLTEQ 1521
Query: 835 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADM 894
K + L++ + +E +Q +++E L +E + + +L +++ +++
Sbjct: 1522 IAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVK---SEV 1578
Query: 895 EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK---ERDVEELQ 951
+ K EKDE +QL + N I + M +++ ND +RLK E D+ E++
Sbjct: 1579 DRKIAEKDEEIDQLKR------NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 952 LKLTKANENASFLQKSIEDM--TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN 1009
++L AN A+ ++ + +K Q + A + +E+ KE +L+ +E++
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE---QLAMVERRANLLQA 1689
Query: 1010 QCQELKARYERATSETKTKHEEILQNLQK---------TLLDTEDKLKGAREENSGLLQE 1060
+ +EL+A E+ K +E+L ++ +L++T+ KL+ + G +++
Sbjct: 1690 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMED 1749
Query: 1061 -LEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK----QTNAKLQNELDTL 1115
L+E R +KAK A T DA + E++ KE+ +T A LE K QT LQ LD
Sbjct: 1750 ILQEARNAEEKAKKAIT--DAAMMAEELKKEQ-DTSAHLERMKKNMEQTVKDLQLRLDEA 1806
Query: 1116 KENNLKNVEELNKSKE--LLTVENQKMEEFRKEIETLK--QAAAQKSQQLSALQEEN--- 1168
++ LK ++ + E + +E + E ++ E +K + ++ ++L+ EE+
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866
Query: 1169 -VKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1223
++L + + + + +V S+++ EE +N L ++ +++A EE+A + +S
Sbjct: 1867 ILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA-EERADIAES 1921
Score = 157 bits (398), Expect = 5e-38
Identities = 239/1124 (21%), Positives = 488/1124 (43%), Gaps = 169/1124 (15%)
Query: 346 KISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLE 405
K + T +KE+ Q I+ LA+ + +R E+ + + + + +L L + + +
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906
Query: 406 LEAKMDQL---RTMVEAADREKVELLNQLEE-------EKRKVED----LQFRVEEESIT 451
E + DQL + +EA +E E EE +KRK+ED L+ +++ +T
Sbjct: 907 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 966
Query: 452 KGDLETQTKLEHARIKELEQSL------LFEKTKADKLQRE----------LEDTRVATV 495
+E + ++K L + + + + TK K +E E+ +V T+
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
Query: 496 SE-KSRIMELEKDLALRVQEVAELRRRLE--SNKPAGDVDMSLSLLQEISSLQEKLEVTR 552
++ K ++ + DL +++ +LR LE K GD+ ++ + +I + +++L+
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086
Query: 553 TDHQREITSLK-----------------EHFGAREETHQKEIKALYTATEK-------LS 588
+ EI++L+ + AR E ++EI+A + K LS
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 589 KENESLKSKLEHANKENSDVIALWKSK----------LETAIASHQQAMEELKVSFSKG- 637
+E E + +LE A S I + K + LE A H+ L+ +
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 638 --LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 695
LG + +K ++EK + + + EI++L A++ + + + L K+ +
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDL--------ASNVETVSKAKGNLEKMCRTL 1258
Query: 696 ENSLEAIRSKLDKAEDQHLV-EMEDTLNKLQ-EAEIKVKELEVLQAKCNEQTKVIDNFTS 753
E+ L ++SK + E Q L+ ++ +LQ E+ ++L+ +A ++ ++ FT
Sbjct: 1259 EDQLSELKSK--EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316
Query: 754 QL----KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASS 809
Q+ + EE++ +AL A + + LR+Q E E+Q E+++ SKA+
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYE--EEQESKAELQR--ALSKAN- 1371
Query: 810 ITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRS---MQET 866
T Q R T+ + E+ + K+ L + LQ +E + + S++++ +Q
Sbjct: 1372 -TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNE 1430
Query: 867 VNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDI-AEIMKM 925
V L E+ N + L+K + N + A++++K E ++A +K + E+ K+
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKI 1490
Query: 926 SGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 985
L D+L +R+ + LQ +++ E + K I ++ ++ K+
Sbjct: 1491 KNAYEESL----DQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL--------EKIKKQ 1538
Query: 986 HEEEKKELERKLSDLEKKMETSHN-------QCQELKARYERATSE-------TKTKHEE 1031
E+EK EL+ L + E +E + ++K+ +R +E K H
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Query: 1032 ILQNLQKTLLDTEDKLKG----AREENSGLLQELEELRKQADK--AKAAQTAEDAMQIME 1085
I++++Q T LD E + + +++ G L E+E A++ A+A + + I++
Sbjct: 1599 IVESMQST-LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 1086 QMTKEKTETLASLEDTKQTNAK-------LQNELDTLK------ENNLKNVE----ELNK 1128
+ L S ED K+ A LQ E++ L+ E + K E + ++
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717
Query: 1129 SKELLTVENQKMEEFRKEIET-----------LKQAAAQKSQQLSALQEENVKLAEELGR 1177
+LL +N + +K++ET + Q A ++ + +AEEL +
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 1178 SRDEVTSHQKLEE--ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKD 1235
+D +++++ E++V + Q L + + E +K K +QK + L E +
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQ-LRLDEAEQLALKGG---KKQIQKLEARVRELEGEVE 1833
Query: 1236 AELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSG 1295
+E ++ V LR K L + + ++L+ V L+ ++K KRQ +
Sbjct: 1834 SEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1893
Query: 1296 NTDTQADEDERAQ------ESQIDFLNSVIVDLQRKNQDLKMKV 1333
++T + + Q E + D S + L+ K++++ KV
Sbjct: 1894 QSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937
Score = 157 bits (397), Expect = 7e-38
Identities = 222/1051 (21%), Positives = 437/1051 (41%), Gaps = 145/1051 (13%)
Query: 387 EIEQELALARDGHDQHVLEL---EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQF 443
E E+E+A ++ + EL EAK +L + +EK +L Q++ E + D +
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 444 RVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIME 503
R ++ TK LE + K E E E+ + E T +R+LED E S + +
Sbjct: 910 RCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELTAK---KRKLED-------ECSELKK 958
Query: 504 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 563
DL L + +V E + NK + L + I+ L ++ + + HQ+ + L
Sbjct: 959 DIDDLELTLAKV-EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL- 1016
Query: 564 EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASH 623
+ + ++ L A KL ++ + L+ LE K D + K KLE +
Sbjct: 1017 -------QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMD-LERAKRKLEGDLKLA 1068
Query: 624 QQA---MEELKVSFSKGLGTETAEFAELKTQIE----------KMRLDYQHEIENLQNQQ 670
Q++ +E K + L + E + L+++IE K + Q IE L+ +
Sbjct: 1069 QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 671 DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 730
++ERA+ RAK K + LE I +L++A ++E +NK +EAE +
Sbjct: 1129 EAERAS--------RAKAEKQRSDLSRELEEISERLEEAGGATSAQIE--MNKKREAEFQ 1178
Query: 731 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD-------ALRKASSEGKSEMKKLR 783
++ +A + + E +D L K SE K E+ L
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 784 QQLEAA-------EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ--- 833
+E EK + LE + + SK R + + LQ E S+
Sbjct: 1239 SNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298
Query: 834 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 893
KE L +L K+ F + EE ++R ++E + + N L+ L+ R +
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEE---LKRQLEEEI-------KAKNALAHALQSSRHDCDL 1348
Query: 894 MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLT--------KMNDELRLKER 945
+ ++ E+ E + +L +A K ++A+ ++ Q T K+ L+ E
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Query: 946 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME 1005
VE + K + LQ +ED+ + E++ A L++K + +K +
Sbjct: 1409 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACA--------ALDKKQRNFDKILA 1460
Query: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
+C+E A E + E ++ E+ + ++ ++ D+L+ + EN L QE+ +L
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFK-IKNAYEESLDQLETLKRENKNLQQEISDLT 1519
Query: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE- 1124
+Q A+ + + +I +Q+ +EK E A+LE+ + A L++E E + ++
Sbjct: 1520 EQI--AEGGKRIHELEKIKKQVEQEKCELQAALEEAE---ASLEHE-----EGKILRIQL 1569
Query: 1125 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS 1184
ELN+ K + ++K+ E +EI+ LK+ + ++ L E+ D +
Sbjct: 1570 ELNQVKSEV---DRKIAEKDEEIDQLKR------NHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 1185 HQKLEEERSVLNNQLLEMKKRESKFIK------------------------DADEEKASL 1220
+K+E + + + QL + ++ ++ D E+ A +
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680
Query: 1221 QKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS----LHSVVQTLESDKVKLELKV 1276
++ ++ A + E A LE+ + E A LH+ +L + K KLE +
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 1277 KNLE------LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLK 1330
++ LQ N + + + E+ + ++ L + ++++ +DL+
Sbjct: 1741 SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQ 1800
Query: 1331 MKVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1361
++++ + AL G + ++ +E + +
Sbjct: 1801 LRLDEAEQLALKGGKKQIQKLEARVRELEGE 1831
Score = 143 bits (361), Expect = 1e-33
Identities = 154/752 (20%), Positives = 337/752 (44%), Gaps = 94/752 (12%)
Query: 656 RLDYQHEIENLQ-------NQQDSERAAHAKEMEALRAKLMKVIK--EKENSLEAIRSKL 706
R++YQ +E + N + H M+ L K+ ++K E E + ++ +
Sbjct: 804 RVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMK-LFFKIKPLLKSAETEKEMATMKEEF 862
Query: 707 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL- 765
K +D+ L ++E K KELE K K ++ Q++A E L D
Sbjct: 863 QKIKDE-----------LAKSEAKRKELE---EKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 766 ---DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLT 822
D L K + ++++K++ ++ E E+ L +K + S + +++ EL L
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 823 NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS 882
+++ + L +E+ L E A+ ++E ++Q + Q+T++ L +E++ N L+
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028
Query: 883 DLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 942
KL + + D+E ++ + L +AK KLE D+ + D ++ +++++L+
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088
Query: 943 KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE------AAKKHEEEKKELERK 996
KE ++ LQ K+ LQK I+++ + E+ ++E + K E+++ +L R+
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1148
Query: 997 LSDLEKKMETS---------HNQCQELK-ARYERATSETKTKHEEILQNLQKTLLDTEDK 1046
L ++ +++E + N+ +E + + R E +HE L+K D+ +
Sbjct: 1149 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE 1208
Query: 1047 LKGAREENSGLLQELEELRKQA-----DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDT 1101
L + + Q+LE+ + + D A +T A +E+M + + L+ L+
Sbjct: 1209 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Query: 1102 KQTNAKLQNELDT----LKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1157
++ +L N+L L+ + + +L++ + L++ ++ + F ++IE LK+ ++
Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328
Query: 1158 SQQLSAL---------------------QEENVKLAEELGRSRDEVTS-HQKLEEERSVL 1195
+ +AL QE +L L ++ EV K E +
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388
Query: 1196 NNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVL----RGE 1251
+L E KK+ ++ ++ A+E + +A + ++L+NEV L
Sbjct: 1389 TEELEEAKKKLAQRLQAAEEH-------VEAVNAKCASLEKTKQRLQNEVEDLMLDVERT 1441
Query: 1252 NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQ 1311
NA+ +L + + + + K + +L+ ++++ S T+ + + A E
Sbjct: 1442 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS----LGTELFKIKNAYEES 1497
Query: 1312 IDFLNSVIVDLQRKNQDLKMKVEMMSEAALNG 1343
+D L + L+R+N++L+ ++ ++E G
Sbjct: 1498 LDQLET----LKRENKNLQQEISDLTEQIAEG 1525
Score = 103 bits (257), Expect = 1e-21
Identities = 136/626 (21%), Positives = 271/626 (43%), Gaps = 62/626 (9%)
Query: 316 LSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLER 375
+ + +++A ++ S LL E +Y + LQ AL + + Q R
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLRE---QYEEEQESKAELQRALSKANTEVAQW---RTKYE 1382
Query: 376 AEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLE--- 432
+ + T + E +++LA ++HV + AK L + E +L+ +E
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 433 ------------------EEKRKVEDLQFRVEEESITKGDLETQT-KLEHARIKELEQSL 473
E K+K E+ +E L T+ K+++A + L+Q L
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ-L 1501
Query: 474 LFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDM 533
K + LQ+E+ D RI ELEK QE EL+ LE + + + +
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEE 1561
Query: 534 SLSLLQEISSLQEKLEVTR--TDHQREITSLKEHF----GAREETHQKEIKALYTAT--- 584
L ++ Q K EV R + EI LK + + + T EI++ A
Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1621
Query: 585 EKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAE 644
+K+ + ++ +L HAN+ ++ + +++ Q +++ ++ L ++ +
Sbjct: 1622 KKMEGDLNEMEIQLNHANRMAAEALRNYRNT--------QGILKDTQIHLDDALRSQE-D 1672
Query: 645 FAELKTQIEKMRLDYQHEIENLQ-NQQDSERAAHAKEMEALRA-KLMKVIKEKENSLEAI 702
E +E+ Q EIE L+ + +ER+ E E L A + ++++ + SL
Sbjct: 1673 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1732
Query: 703 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL----KAT 758
+ KL+ Q EMED L + + AE K K+ A E+ K + ++ L K
Sbjct: 1733 KKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1792
Query: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
E+ + DL LR +E + +K ++Q++ E +++ LE E +E + + + L+ E
Sbjct: 1793 EQTVKDLQ-LRLDEAE-QLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850
Query: 819 LKLTNL-------QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH 871
++ L ++N+ + + + L+ +++ K + EA E++ + ++ ++L
Sbjct: 1851 RRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELE 1910
Query: 872 QKEEQFNMLSSDLEKLRENLADMEAK 897
+ EE+ ++ S + KLR ++ K
Sbjct: 1911 EAEERADIAESQVNKLRVKSREVHTK 1936
Score = 97.4 bits (241), Expect = 8e-20
Identities = 159/689 (23%), Positives = 291/689 (42%), Gaps = 98/689 (14%)
Query: 326 VSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHV 385
++ ++ G L S ++R++ AL L +Q Q + E + E KA + +
Sbjct: 1276 INDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNAL 1335
Query: 386 GEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRV 445
AL HD D LR E K EL L + +V + +
Sbjct: 1336 AH-----ALQSSRHD---------CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381
Query: 446 EEESITKGD-LETQTKLEHARIKELEQSL--------LFEKTKADKLQRELED------- 489
E ++I + + LE K R++ E+ + EKTK +LQ E+ED
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK-QRLQNEVEDLMLDVER 1440
Query: 490 TRVATVSEKSRIMELEKDLALRVQEVAELRRRLE-SNKPAGDVDMSL----SLLQEISSL 544
T A + + +K LA Q+ E LE S K A + L + +E
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 545 QEKLEVTRTDHQREITSLKEHF---GAREETHQKEIKALYTATEKLSKENESLKSKLEHA 601
E L+ + Q+EI+ L E G R +K K + +L E ++ LEH
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEH- 1559
Query: 602 NKENSDVIALW------KSKLETAIASHQQAMEELKVSFSKGLGTETAEF-AELKTQIEK 654
E ++ + KS+++ IA + +++LK + + + + + AE++++ +
Sbjct: 1560 --EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDA 1617
Query: 655 MRLDYQHEIENLQNQQDSERAAHAKEMEALR--AKLMKVIKEKENSLE-AIRSKLDKAED 711
+RL + E +L + A+ EALR ++K+ + L+ A+RS+ D E
Sbjct: 1618 IRLKKKME-GDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ 1676
Query: 712 QHLVEMEDTLNKLQEAEI-----------KVKELEVLQAKCNEQTKVIDNFTSQLKATEE 760
+VE L + + E+ K+ E E+L A +E+ +++ + L T++
Sbjct: 1677 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA--SERVQLLHTQNTSLINTKK 1734
Query: 761 KLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH-------LEIEKNAESSKASSITRE 813
KL S+ + EM+ + Q+ AE++ K + E E ++ + R
Sbjct: 1735 KL------ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1788
Query: 814 LQGRELKLTNLQENLSEVSQVK-ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 872
+ E + +LQ L E Q+ + +K++Q L+ + E E S Q+ E V L +
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK 1848
Query: 873 KEEQFNMLSSDLEKLRENL-----------ADMEAKFREKDEREEQL---IKAKEKLEND 918
E + L+ E+ R+N+ A +++ R+ +E EEQ + KL+++
Sbjct: 1849 HERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHE 1908
Query: 919 IAEIMKMSGDNSSQLTKMNDELRLKERDV 947
+ E + + SQ+ K LR+K R+V
Sbjct: 1909 LEEAEERADIAESQVNK----LRVKSREV 1933
Score = 33.9 bits (76), Expect = 1.2
Identities = 33/136 (24%), Positives = 58/136 (42%), Gaps = 10/136 (7%)
Query: 352 ALQEALKEKQQHIEQLLAE-RDLE---------RAEVAKATSHVGEIEQELALARDGHDQ 401
A Q ALK ++ I++L A R+LE AE K +EL + +
Sbjct: 1806 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1865
Query: 402 HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKL 461
++L L+ +D+L+ V++ R+ E Q K LQ +EE E+Q
Sbjct: 1866 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925
Query: 462 EHARIKELEQSLLFEK 477
+ +E+ ++ E+
Sbjct: 1926 LRVKSREVHTKVISEE 1941
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 187 bits (476), Expect = 5e-47
Identities = 240/1138 (21%), Positives = 503/1138 (44%), Gaps = 166/1138 (14%)
Query: 353 LQEALKEKQQHIEQLLAERD----LERAE------VAKATSHVGEIEQELALA------- 395
LQ +LKE++ + E+L E + L++ E V +++ + +EQ+L A
Sbjct: 95 LQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNI 154
Query: 396 ---RDGHDQ-------HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFR- 444
+D +Q + ++++K D+ R++ EAA+++ L +L +E ++DL+
Sbjct: 155 KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL 214
Query: 445 -----VEEESITKGDL-ETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEK 498
+E+ ++ K +L + QT +++ ++ +S K + KLQ + + +
Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL-KDECKKLQSQYASSEATISQLR 273
Query: 499 SRIMELEKDLALRVQEVAELRRRLE--SNKPAGDVDMSLSLLQEISSLQEK--------L 548
S + + +++A+ VQE+ +L+ + + K + L Q+ + L+EK
Sbjct: 274 SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKK 333
Query: 549 EVTRTDHQREIT--SLKEHFGAREETHQK---EIKALYTATEKLSKENESLKSKLEHANK 603
+ T HQ+++ L+ A E + + E+ AT+KL +E +++K +H
Sbjct: 334 NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
Query: 604 E------------------NSDVIALWKSKLETAIA---SHQQAMEELKVSFSKGLGTET 642
E S++ L LET +H + E+ ++S K + E
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 643 AEFAELKTQIEKMRLDYQHEIEN---LQNQQDSERAAHAKEMEALRAKLMKVIKEKENSL 699
+ A+L+ ++ ++ + ++ N LQ+Q D + H +E +AL+ ++E +N L
Sbjct: 454 -QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH-QEQQALQQSTTAKLREAQNDL 511
Query: 700 EAIRSKLDKAEDQHLVEMEDTLNKLQE-AEIKVKELEVLQAKCNE---QTKVIDNFTSQL 755
E + ++ +DQ + +E L K +E + KE E L AK +T V++ +
Sbjct: 512 EQVLRQIGD-KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKN 570
Query: 756 KATEEKLLDL-DALRKASSEGKSEMKKLRQQ-------LEAAEKQIKHLEIEKNAESSKA 807
+E++ L + L+ S K + L Q L AA+ ++ LE N +S+
Sbjct: 571 HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL 630
Query: 808 SSITRELQGRELKLTNLQENLSEVSQVKET----LEKELQILKEKFAEASEEAVSVQRSM 863
+ ++ ++++ E L K L+ L + + +E + +
Sbjct: 631 NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 690
Query: 864 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL------IKA-KEKLE 916
+ KL K+E + L S L++ +E +E K E + + ++L +KA KE+
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750
Query: 917 NDIAEIMKMSGDNSSQLTKMNDELRL--------------KERDVEELQLKLTKANENAS 962
D+ + +++ D + T+++ +L + K +E ++ KLTK E
Sbjct: 751 QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810
Query: 963 FLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEK-KME-----TSHNQCQELKA 1016
L++ E ++ QE +HEE ++ +++L+K KME T + ++ +
Sbjct: 811 ILKQDFETLS-------QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863
Query: 1017 RYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE----ENSGLLQELEELRKQADKAK 1072
+ + +K++ E+ Q + +LD E K + + L+E +EL+K +K K
Sbjct: 864 KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK 923
Query: 1073 AA------------QTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT----LK 1116
A + A ++Q KE+ + ++ + KQ++ + + +++ LK
Sbjct: 924 EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
Query: 1117 ENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELG 1176
L+ E NK ++ LT Q++ +++I L+ + + LQ + EL
Sbjct: 984 IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043
Query: 1177 RSRDEVTSHQKLEEERSVLNNQLLEMKKR---ESKFIKDADEEKASLQKSISITSALLTE 1233
+R ++ S +EE+ S+ L+ + + ++K I++ KA+L++ + L E
Sbjct: 1044 ATRQDLKS---VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100
Query: 1234 KDAELEKLRNEVTVLRGENASAKSLHSVVQTL------ESDKVKLELKVKNLE-----LQ 1282
+ L+ ++ E ++ E + KS + ++ + E K+ ELK LE
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1160
Query: 1283 LKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAA 1340
LK+ K+ L +AD + A E + N I+ Q K ++ ++K E + + A
Sbjct: 1161 LKDAKQLLIQQKLELQGKADSLKAAVEQ--EKRNQQILKDQVKKEEEELKKEFIEKEA 1216
Score = 174 bits (442), Expect = 4e-43
Identities = 225/1040 (21%), Positives = 460/1040 (44%), Gaps = 133/1040 (12%)
Query: 336 LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALA 395
L+E ++Y + LQ+ +EK+QH QL +E + +++ + +GE L
Sbjct: 381 LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ 440
Query: 396 RD-------GHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEE 448
R +Q V +L+ K+ +L ++ EL +QL++ K++ ++ Q +
Sbjct: 441 RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQ-- 498
Query: 449 SITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEK-- 506
T KL A+ +LEQ L + DK Q+ +++ K I LEK
Sbjct: 499 -------STTAKLREAQ-NDLEQVL---RQIGDKDQK-IQNLEALLQKSKENISLLEKER 546
Query: 507 -DLALRVQ----EVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITS 561
DL ++Q E A L + E N +L ++++ L EKL+ H++
Sbjct: 547 EDLYAKIQAGEGETAVLNQLQEKNH---------TLQEQVTQLTEKLKNQSESHKQ---- 593
Query: 562 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA 621
+E+ + + + ++A L L S+L + ++ S + K+K E +
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE-LLL 652
Query: 622 SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEM 681
S + A + L T + + ++ K+ LQ++Q+ H ++
Sbjct: 653 SAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE-----HCSQL 707
Query: 682 EALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKC 741
E+ +K KEK SLE Q E+E + KL+ ++VK + +
Sbjct: 708 ES----HLKEYKEKYLSLE-----------QKTEELEGQIKKLEADSLEVKASKEQALQD 752
Query: 742 NEQTKVIDNFTSQLKATE-EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK 800
+Q + + N +L+ATE K L+++ ++ S + +++K + LE+ ++++ E EK
Sbjct: 753 LQQQRQL-NTDLELRATELSKQLEME--KEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809
Query: 801 NAESSKASSITRELQGRELKLTN-LQENLSEVSQV---KETLEKELQILKEKFAEASEEA 856
++++E + + +L N +Q ++E+ +V KE L EL +K+K ++ S+
Sbjct: 810 QILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSD-- 867
Query: 857 VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL-----ADMEAKFREKDEREEQLIKA 911
S++ + ++ ++ ++ DLEK + L ME +E+ E ++ L K
Sbjct: 868 -----SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
Query: 912 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE-- 969
KE E+ M QL + + L+ E++ ++LQ + + +++ +K IE
Sbjct: 923 KEASHQLKLELNSM----QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
Query: 970 ------------DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 1017
++ K +Q +AA++ EK+ K+S L+ E S ++L++
Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKE----KISVLQNNYEKSQETFKQLQSD 1034
Query: 1018 YERATSETKTKHEEILQNLQKTLLDTEDKLKGARE--ENSGLLQELEELRK--QADKAKA 1073
+ SE +++ +K L ED + + + L+QEL+ + + D AK
Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK 1094
Query: 1074 AQTAEDAMQIMEQMTKEKT----------ETLASLEDTK----QTNAKLQNELDTLKENN 1119
Q ++ + ++ + KEK+ LA +E+ K + KL EL + K +
Sbjct: 1095 EQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1154
Query: 1120 LKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSR 1179
+K + L +K+LL Q+ E + + ++LK A Q+ + L+++ K EEL +
Sbjct: 1155 IKEITNLKDAKQLLI---QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL--KK 1209
Query: 1180 DEVTSHQKLEEERSVLNNQLLEMKKRESKF---IKDADEEKASLQKSISITSALLTEKDA 1236
+ + KL E + + ++ E+K I +E +++K + ++E +
Sbjct: 1210 EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK 1269
Query: 1237 ELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGN 1296
+ + LR E+ VL A+ ++ + L +K E +++ L+ ++ E +R+L +++
Sbjct: 1270 QTDDLRGEIAVL---EATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAA 1326
Query: 1297 TDTQADEDERAQESQIDFLN 1316
E++ Q LN
Sbjct: 1327 VQELGRENQSLQIKHTQALN 1346
Score = 110 bits (276), Expect = 7e-24
Identities = 147/700 (21%), Positives = 300/700 (42%), Gaps = 118/700 (16%)
Query: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGH---DQHVLELEAKM 410
Q AL++KQQ + ++ + D A++ H ++E L ++ + +Q ELE ++
Sbjct: 673 QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
Query: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRV------------------------- 445
+L K + L L+++++ DL+ R
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792
Query: 446 --------------EEESITKGDLET---QTKLEHARIKELEQSLLFEKTKADKLQRELE 488
EE+ I K D ET +TK++H + Q+ + E K K+++E
Sbjct: 793 EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV-KMEKEAL 851
Query: 489 DTRVATVSEK-----------------------SRIMELEKDLA-----LRVQ------E 514
T ++TV +K + I++LEK L+VQ E
Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 515 VAELRRRLESNKPAGDVDMSLSLLQEISSLQEKL---EVTRTDHQREITSLKEHFGAREE 571
EL++ LE K A S L E++S+QE+L + T +++E L+ + ++
Sbjct: 912 QKELKKSLEKEKEA-----SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
Query: 572 THQ---KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME 628
+ + K+I+AL + + L++KL+ + + +A K K+ +++++ E
Sbjct: 967 SSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026
Query: 629 ELKVSFSKGLGTETAEFA---ELKTQIEKMRLDYQHEIENL-----QNQQDSERAAHAKE 680
K S G E+ A +LK+ EK+ L + I N QN+ E
Sbjct: 1027 TFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKAT 1086
Query: 681 MEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV-KEL----E 735
+E AK + ++E+ +L+ I+ K +++ LV + L +++E + + KE+ E
Sbjct: 1087 LEQDSAKKEQQLQERCKALQDIQ-KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE 1145
Query: 736 VLQAKCNEQTKVIDNFTSQLKATEEKLLDL----DALRKASSEGKSEMKKLRQQLEAAEK 791
L++ E K I N + ++ L+L D+L+ A + K + L+ Q++ E+
Sbjct: 1146 ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEE 1205
Query: 792 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 851
++K IEK A+ + E++ +E+ + +EN ++++ L + L +K+++
Sbjct: 1206 ELKKEFIEKEAK------LHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQS 1259
Query: 852 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 911
+ +++ + ++ E + L E E E ++ + ++++
Sbjct: 1260 SQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEG---EIEKLQTKVLEL 1316
Query: 912 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQ 951
+ KL+N A + ++ +N S K L K + E+Q
Sbjct: 1317 QRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
Score = 86.3 bits (212), Expect = 2e-16
Identities = 122/513 (23%), Positives = 221/513 (43%), Gaps = 54/513 (10%)
Query: 871 HQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG--- 927
H E + D+ LR+ + D++A +E+ E+L K EK + + K G
Sbjct: 72 HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVT 131
Query: 928 DNSSQLTKMNDELRLKERDVEELQLKLTK--ANENASFLQKSIEDMTVK--AEQSQQEAA 983
D+S++L + E +L+E E +K K + A+ L I D+ K E+S +EAA
Sbjct: 132 DSSAELQSL--EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAA 189
Query: 984 KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDT 1043
E+K++ L +++ Q+LK T + E + L+K L+
Sbjct: 190 ----------EQKVTRLTEELNKEATVIQDLK------TELLQRPGIEDVAVLKKELVQV 233
Query: 1044 EDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA--MQIMEQMTKEKTET---LASL 1098
+ + E +E E+L+ + K ++ + +A Q+ ++ K E + L
Sbjct: 234 QTLMDNMTLERE---RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQEL 290
Query: 1099 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKS 1158
+ K + +L + TL EN LK ++ K +E E+ + + + Q
Sbjct: 291 QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ 350
Query: 1159 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK- 1217
+LSA + ++ EL + E T QKL+EE S + + + K E K ++ EEK
Sbjct: 351 SRLSASETSLHRIHVELS-EKGEAT--QKLKEELSEVETKYQHL-KAEFKQLQQQREEKE 406
Query: 1218 ---ASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLEL 1274
LQ I+ + L E + +L + + R + +S K + E L+L
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR-QLSSEKLMDK-----EQQVADLQL 460
Query: 1275 KVKNLELQLKE---NKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQ---RKNQD 1328
K+ LE QLKE N +L T Q E + Q+S L DL+ R+ D
Sbjct: 461 KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520
Query: 1329 LKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1361
K++ + EA L + ++++ + + ++ +K
Sbjct: 521 KDQKIQNL-EALLQKSKENISLLEKEREDLYAK 552
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 185 bits (469), Expect = 3e-46
Identities = 238/1007 (23%), Positives = 441/1007 (43%), Gaps = 147/1007 (14%)
Query: 352 ALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD----------GHDQ 401
+L + E QQ +E ++AE++ + ++ + E ++EL L D
Sbjct: 1047 SLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKN 1106
Query: 402 HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKR-------KVEDLQFRVEEESITKGD 454
H ++ E ++ + + + + E QL+E+++ ++ ++Q ++ E K +
Sbjct: 1107 HAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNE 1166
Query: 455 LET-QTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQ 513
L+ + LEH + LE A KL E+ + T E+ + EL+K
Sbjct: 1167 LKNKELTLEHMETERLE--------LAQKLNENYEEVKSIT-KERKVLKELQKSFETERD 1217
Query: 514 EVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETH 573
+ R +E+ L +E+ L+ +HQ I L+ E+T
Sbjct: 1218 HLRGYIREIEAT--------GLQTKEELKIAHIHLK----EHQETIDELRR--SVSEKTA 1263
Query: 574 QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS 633
Q T+ L K + L+ ++ ++E +++ K ET Q+ M EL++
Sbjct: 1264 Q------IINTQDLEKSHTKLQEEIPVLHEE-QELLPNVKEVSET-----QETMNELELL 1311
Query: 634 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 693
+ ++ A + ++E++RL+ E Q Q+ ++ + K
Sbjct: 1312 TEQSTTKDSTTLARI--EMERLRLN-----EKFQESQE---------------EIKSLTK 1349
Query: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 753
E++N L+ I+ L+ DQ + +TL K+QE++ K ++ ++ K NE TK++
Sbjct: 1350 ERDN-LKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEM-E 1407
Query: 754 QLKATEEKLLDLD----ALRKASSEGKSEMK----------KLRQQLEAAEKQI------ 793
Q K + LL ++ L K E EMK +L++ L++ Q+
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467
Query: 794 ---KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA 850
KHLE E+ + + +E EL++ NL E +E+S +++ LE L+ K
Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRV-NLSEKETEISTIQKQLEAINDKLQNKIQ 1526
Query: 851 E--ASEEAVSVQR--SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREE 906
E EE ++++ +QE VN+L Q +E S L+ + + ++ + +E E +
Sbjct: 1527 EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586
Query: 907 QLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQ-LKLTKANE------ 959
+IK KE+++ + E +++ D + TK ++KE +E Q LK+T NE
Sbjct: 1587 IMIKEKEEMKR-VQEALQIERDQLKENTK-EIVAKMKESQEKEYQFLKMTAVNETQEKMC 1644
Query: 960 NASFLQKSIEDMTVKAEQSQQEAAK----KHE--EEKKELERKLSDLEKKMETSHNQCQE 1013
L++ E + E + E + HE EE + + ++ DL ET + +
Sbjct: 1645 EIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQ 1704
Query: 1014 LKARYERATSETKTKHEE--ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA 1071
LK + K EE I+ K +T DKL+G E + + +++ + ++ A
Sbjct: 1705 LKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDA 1764
Query: 1072 KAAQ--TAEDAMQIMEQMTKEKTETLASLED-TKQTNAKLQNELDTLKENNLKNVEELNK 1128
AQ ++ ++I KE+ ET+ L + KL N L+ +N K E++ +
Sbjct: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824
Query: 1129 SK----ELLTVENQKMEEFRK--EIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1182
K +L+T++ E +K E+E LK+ +S LS L+ EN+ LA++L
Sbjct: 1825 LKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL------- 1877
Query: 1183 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQ----KSISITSALLTEKDAEL 1238
H+ LEE +SV+ + +++ E + D+ K SLQ + + I L T + L
Sbjct: 1878 --HENLEEMKSVMKER-DNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTAR--ML 1932
Query: 1239 EKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKE 1285
K E E S K++ + DK K EL+ K ELQ KE
Sbjct: 1933 SKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKE 1979
Score = 179 bits (454), Expect = 2e-44
Identities = 217/1099 (19%), Positives = 493/1099 (44%), Gaps = 149/1099 (13%)
Query: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
+ L+EK + +++ L E + + ++ S + +E+E L + +L+ +++++
Sbjct: 873 QELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITE-------KLQQTLEEVK 925
Query: 415 TMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHA--RIKELEQS 472
T+ + D L QL +E ++E Q + + +++TQ +L +A +K+ +++
Sbjct: 926 TLTQEKDD-----LKQL-QESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979
Query: 473 LLFEKTK-ADKLQREL---EDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPA 528
+ K+K ++++ R L E+T + +++ ++K L + L ++ N+
Sbjct: 980 INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 529 GDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLS 588
SL+QE + LQ+ LE + ++ T LKE+ E +Q+E++ L ++L
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIE-NQEELRLL---GDELK 1095
Query: 589 KENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL 648
K+ E + + HA K+ ++ S+ +A ++ ++E S+ L + + +
Sbjct: 1096 KQQEIVAQEKNHAIKKEGEL-----SRTCDRLAEVEEKLKEK----SQQLQEKQQQLLNV 1146
Query: 649 KTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIR----- 703
+ ++ +M+ +EIENL+N+ ++ + ME R +L + + E +++I
Sbjct: 1147 QEEMSEMQKKI-NEIENLKNELKNKELT-LEHMETERLELAQKLNENYEEVKSITKERKV 1204
Query: 704 -SKLDKAEDQHLVEMEDTLNKLQEAEIKVK-ELEVLQAKCNEQTKVIDNFTSQLKATEEK 761
+L K+ + + + +++ ++ K EL++ E + ID + +
Sbjct: 1205 LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ 1264
Query: 762 LLDLDALRKASSEGKSEMKKLRQQLE---------AAEKQIKHLEIEKNAESSKASSITR 812
+++ L K+ ++ + E+ L ++ E ++ + LE+ ++K S+
Sbjct: 1265 IINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLA 1324
Query: 813 ELQGRELKLT-NLQENLSEVSQ----------VKETLEKELQILKEKFAEASEEAVSVQR 861
++ L+L QE+ E+ +KE LE + LKE E + Q
Sbjct: 1325 RIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQS 1384
Query: 862 SMQETVN---------KLHQKEEQFNMLSSDL-----------EKLRENLADMEAKFREK 901
++++N K+ + EQF S L ++L+E+ +M++ +EK
Sbjct: 1385 KQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK 1444
Query: 902 DE---REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKAN 958
D+ +E L ++L+ +I EI+ + +L + L+ +E + EL++ L++
Sbjct: 1445 DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE 1504
Query: 959 ENASFLQKSIEDMTVKAEQSQQEAAKKHEE----EKKELERKLSDL----------EKKM 1004
S +QK +E + K + QE +K E+ + E++ K+++L + +
Sbjct: 1505 TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSAL 1564
Query: 1005 ETSHNQCQELKARYERATSETK--TKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE 1062
++ ++ EL R + + E + K +E ++ +Q+ L D+LK +E ++E +
Sbjct: 1565 QSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624
Query: 1063 ELRKQADKAKAAQTAEDAM----------------------------QIMEQMTKEKTET 1094
E Q K A ++ M QI+ + +E
Sbjct: 1625 EKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV 1684
Query: 1095 LASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAA 1154
+D + L+ E D LKEN + + + +E L + + ++E ++ I+ L+
Sbjct: 1685 TKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV 1744
Query: 1155 AQKSQQLSALQEENVKLAEELGRSRDEVTSHQ-KLEEERSVLNNQLLEMKKRESK---FI 1210
++K+ ++S +Q ++L S D + + K++EE + + L E ++ K +
Sbjct: 1745 SEKTNEISNMQ-------KDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIV 1797
Query: 1211 KDADEEKASLQKSISITSALLTEKDAELEKLRNE-VTVLRGENASAKSLHSVVQTLESDK 1269
+ ++ +++QK + ++A L EK EL+ ++ +T+ + N + K + + Q + K
Sbjct: 1798 SEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIK 1857
Query: 1270 ------VKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQ 1323
KLE++ NL +L EN ++ S D +E + + S+ +
Sbjct: 1858 DQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESL---QE 1914
Query: 1324 RKNQDLKMKVEMMSEAALN 1342
K +DL+++ E+ + L+
Sbjct: 1915 TKARDLEIQQELKTARMLS 1933
Score = 166 bits (419), Expect = 2e-40
Identities = 246/1113 (22%), Positives = 478/1113 (42%), Gaps = 231/1113 (20%)
Query: 406 LEAKMDQLRTMVEAADREKVEL-LNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHA 464
+E++++ LR AD + + L QL EK E+++ +++E K DL+ LE
Sbjct: 496 IESELNSLR-----ADYDNLVLDYEQLRTEK---EEMELKLKE----KNDLDEFEALERK 543
Query: 465 RIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLES 524
K+ E L+ E + L + E +LE +L+ +V+ + E +++
Sbjct: 544 TKKDQEMQLIHEISNLKNLVKHAEVYN----------QDLENELSSKVELLREKEDQIKK 593
Query: 525 NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTAT 584
LQE Q KLE + D + S+++ ++ E AL
Sbjct: 594 -------------LQEYIDSQ-KLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKR 639
Query: 585 EK--LSKENESLKSKLEH---ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLG 639
E L EN LK K++ K+ + I L++S+LE A ++++V K L
Sbjct: 640 ESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLE--------AKKKMQVDLEKELQ 691
Query: 640 TETAEFAELKTQIEKM-------RLDYQHEIENLQNQQDSERAAHAKEMEALRAK--LMK 690
+ E +L + I+ L+ + +I +LQ + + E +E EALR + L+
Sbjct: 692 SAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKE----VEENEALREEVILLS 747
Query: 691 VIKEKENSLEAIRSKL-DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 749
+K + +E +R ++ DK+E+ H++ E +KL +E+ KE V Q E K D
Sbjct: 748 ELKSLPSEVERLRKEIQDKSEELHIITSEK--DKLF-SEVVHKESRV-QGLLEEIGKTKD 803
Query: 750 NFT---SQLKATEE-----KLLDLDALRK------ASSEGKSEMKKLRQQLEAAEKQIKH 795
+ S K+T++ K L +D +K + E+ L ++ + + +
Sbjct: 804 DLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGA 863
Query: 796 LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEE 855
L+ E + ++ + TRE+Q R ++ L+E L +T+E+E ++ EK + EE
Sbjct: 864 LKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE 923
Query: 856 A-----------------------------------VSVQRSMQETVNKLHQKEEQFNML 880
+ Q ++ + L Q +E N L
Sbjct: 924 VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL 983
Query: 881 SSDL-EKLRENL-----------------------ADMEAK------------------- 897
S + E++ NL D+EAK
Sbjct: 984 KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQR 1043
Query: 898 -----FREKDERE---EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949
+EK+E + E +I KE+L+ D+ E ++M+ +N +L + DEL+ ++ V +
Sbjct: 1044 KIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQ 1103
Query: 950 LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH------EEEKKELERKLSDLE-- 1001
+ K S + ++ K ++ Q+ +K +EE E+++K++++E
Sbjct: 1104 EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL 1163
Query: 1002 ------KKMETSHNQ------CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1049
K++ H + Q+L YE S TK + ++L+ LQK+ D L+G
Sbjct: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVKSITKER--KVLKELQKSFETERDHLRG 1221
Query: 1050 -AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKL 1108
RE + LQ EEL+ K Q D ++ + EKT + + +D ++++ KL
Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELR---RSVSEKTAQIINTQDLEKSHTKL 1278
Query: 1109 QNELDTLKENN--LKNVEELNKSKELLTVENQKMEEFRKEIETL-KQAAAQKSQQLSALQ 1165
Q E+ L E L NV+E+++++E + E+E L +Q+ + S L+ ++
Sbjct: 1279 QEEIPVLHEEQELLPNVKEVSETQETM-----------NELELLTEQSTTKDSTTLARIE 1327
Query: 1166 EENVKLAEELGRSRDEVTSHQK-------LEEERSVLNNQLLEMKKRESKFIKDA---DE 1215
E ++L E+ S++E+ S K ++E V ++QL E + I+++ E
Sbjct: 1328 MERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387
Query: 1216 EKASLQKSISITSALLTE----KDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVK 1271
+ ++++ + T+ +++E K + LR E+ +L G + + H ++++ +K
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML-GLSKRLQESHDEMKSVAKEKDD 1446
Query: 1272 LELKVKNLEL---QLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQD 1328
L+ + L+ QLKEN +++ + T+ + + Q + +N + V+L K +
Sbjct: 1447 LQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506
Query: 1329 LKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1361
+ + L D L N + EK+ +
Sbjct: 1507 IS-----TIQKQLEAINDKLQNKIQEIYEKEEQ 1534
Score = 144 bits (363), Expect = 6e-34
Identities = 257/1250 (20%), Positives = 506/1250 (40%), Gaps = 295/1250 (23%)
Query: 337 TETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALAR 396
T+ S+ AR L E +E Q+ I+ L ERD ++ I++ L +
Sbjct: 1317 TKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERD-----------NLKTIKEALEVKH 1365
Query: 397 DGHDQHVLELEAKMDQLRTMVEAA------DREKVELLNQLEEEKRKVEDLQFRVEEESI 450
D +H+ E AK+ + ++ E + D E ++++++E+ K K L R+E E +
Sbjct: 1366 DQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSAL-LRIEIEML 1424
Query: 451 ------------------TKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRV 492
K DL+ ++ + +L++++ K + + EL+
Sbjct: 1425 GLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC 1484
Query: 493 ATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTR 552
++ I EL +L+ + E++ ++++LE+ D + +QEI +E+ + +
Sbjct: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAIN-----DKLQNKIQEIYEKEEQFNIKQ 1539
Query: 553 TDHQRE----ITSLKEHFGARE-----------------ETHQKEIKALYTATEKLSKEN 591
+E + KEH A++ + Q+EI+ + E++ +
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 592 ESLKSKLEHANKENSDVIALWKSKLE--------TAIASHQQAM---EELKVSFS----- 635
E+L+ + + + +++A K E TA+ Q+ M E LK F
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN 1659
Query: 636 -KGLGTE------------------TAEFAELKTQIEKMRLDYQHEIENLQNQ--QDSER 674
+ + TE T E +L++ E ++++ ENL+ +D E+
Sbjct: 1660 LENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEK 1719
Query: 675 AA-------HAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED---------------- 711
H KE + KL ++ EK N + ++ L+ + D
Sbjct: 1720 QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIA 1779
Query: 712 -QHLVEMEDTLNKLQE-AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR 769
HL E ++T++KL+ K +L +Q + +LKA E +L+ L
Sbjct: 1780 HMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDV 1839
Query: 770 KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS 829
+ + SEM++L++Q++ + LEIE ++ ++L ++ ++ +
Sbjct: 1840 NETQKKVSEMEQLKKQIKDQSLTLSKLEIEN-------LNLAQKLHENLEEMKSVMKERD 1892
Query: 830 EVSQVKETLEKELQILKEKFAEASEEAVSVQRSM----------QETVNKLHQKEEQFNM 879
+ +V+ETL+ E LKE E + +Q+ + +ETV+KL +K + +
Sbjct: 1893 NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTI 1952
Query: 880 LSSDLEK-LRENLADMEAKFREKDEREEQLIKAKE------KLENDIAEIMK-MSGDNSS 931
SD++K L ++ +++ K +E ++E QL++ KE K N++ ++ K N S
Sbjct: 1953 QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLS 2012
Query: 932 ---------QLTK----MNDELRLKERDVEEL-QLKLTKANENASFLQKSIEDMTVKAEQ 977
QLTK +E+R+ ++ +EL ++K + E F+ ++ +M + Q
Sbjct: 2013 MQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFI-ATLREMIARDRQ 2071
Query: 978 SQQ----------------EAAKKHEEEKKELERKLS--------------DLEKKMETS 1007
+ Q E+ ++ KEL ++ S DLEK++E
Sbjct: 2072 NHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQ 2131
Query: 1008 HNQCQELKARYERATSETK-------------TKHEEILQNLQKTLLDTEDKLKGAREE- 1053
+KA +TK + I++ L K +L K+K + E
Sbjct: 2132 KELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKL-KYVLSYVTKIKEEQHES 2190
Query: 1054 -NSGLLQELEELRKQADKAKAAQTAEDAMQI-----------------MEQMTKEKTET- 1094
N + ++E+ KQ + Q + + +E++ K+ +E+
Sbjct: 2191 INKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESE 2250
Query: 1095 LASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK--------------- 1139
S++ Q + E+ E L ++ K K + EN +
Sbjct: 2251 FPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAI 2310
Query: 1140 MEEFRKEIETLKQAAAQKSQQLSALQEENVKL--------------AEELGRSRDEVTSH 1185
M E + E + + Q L +L+E+N KL A+ ++D H
Sbjct: 2311 MNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPH 2370
Query: 1186 ------QKLEEERSVLNNQLLEMKK----RESKFIKDADEEKASLQKSISITSALLTEKD 1235
Q E+ L N L E K+ +ESK IK +QK + +T+ ++ +
Sbjct: 2371 VTSRATQLTTEKIRELENSLHEAKESAMHKESKIIK--------MQKELEVTNDIIAKLQ 2422
Query: 1236 AE-------LEKLRNEVTVLRGENA-SAKSLHSVVQTLESDKVKLEL-KVKNLELQLKEN 1286
A+ LEK + + VL+ + A AK ++ L+ VK++L K+KN KE
Sbjct: 2423 AKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKN----AKEF 2478
Query: 1287 KRQLSSSSGNTDTQ-------ADEDERAQESQIDFLNSVIVDLQRKNQDL 1329
++++S++ + Q + R+Q++Q + S D Q N+ L
Sbjct: 2479 EKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPL 2528
Score = 141 bits (356), Expect = 4e-33
Identities = 214/997 (21%), Positives = 450/997 (45%), Gaps = 121/997 (12%)
Query: 404 LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE--ESITK--------- 452
LEL+ KM +L T + + + +QLE +K+ DL+ ++ ITK
Sbjct: 649 LELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV 708
Query: 453 -GDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSE-KSRIMELEKDLAL 510
DL +LE +I +L++ L E + + L+ E V +SE KS E+E+ L
Sbjct: 709 PKDLLCNLELE-GKITDLQKELNKEVEENEALREE-----VILLSELKSLPSEVER-LRK 761
Query: 511 RVQEVAELRRRLESNKP------AGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKE 564
+Q+ +E + S K LL+EI ++ L T+++++ S +
Sbjct: 762 EIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYK----STDQ 817
Query: 565 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ 624
F + H + E+ + N+ + + + A K +S + A L+T ++
Sbjct: 818 EFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGA-----LKTELSYKT 872
Query: 625 QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 684
Q ++E +T E E ++E+++ ++ LQ + + K + L
Sbjct: 873 QELQE-----------KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTL 921
Query: 685 RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE-LEVLQAKCNE 743
+K + ++++ L+ ++ L DQ ++ DT+N + + +++ LE L+ +
Sbjct: 922 EE--VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK----Q 975
Query: 744 QTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAE 803
+ I+ S++ + L ++ E E K QQ + + LE KN +
Sbjct: 976 HQETINTLKSKISEEVSRNLHME-------ENTGETKDEFQQKMVGIDKKQDLE-AKNTQ 1027
Query: 804 SSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSM 863
+ A E+ ++ K+ +L + +E+ Q+ E++ E + LK E E + Q +
Sbjct: 1028 TLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL 1087
Query: 864 QETVNKLHQKEE-------QFNMLSSDLEKLRENLADMEAKFREK----DEREEQLIKAK 912
+ ++L +++E +L + + LA++E K +EK E+++QL+ +
Sbjct: 1088 RLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ 1147
Query: 913 EKLENDIAEIMKMSGDNSSQLTKM-NDELRLKERDVEELQLKLTKANENASFLQKSIEDM 971
E +++E+ K + + ++ N EL L+ + E L+L K NEN + ++ +
Sbjct: 1148 E----EMSEMQKKINEIENLKNELKNKELTLEHMETERLEL-AQKLNEN----YEEVKSI 1198
Query: 972 TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEE 1031
T K + +E K E E+ L + ++E T +ELK + +T E
Sbjct: 1199 T-KERKVLKELQKSFETERDHLRGYIREIE---ATGLQTKEELKIAHIHLKEHQETIDEL 1254
Query: 1032 ILQNLQKT--LLDTEDKLKG---AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQ 1086
+KT +++T+D K +EE L +E E L + ++ +T + + EQ
Sbjct: 1255 RRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQ 1314
Query: 1087 MTKEKTETLASLE-DTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEE-FR 1144
T + + TLA +E + + N K Q + +K + K + L KE L V++ +++E R
Sbjct: 1315 STTKDSTTLARIEMERLRLNEKFQESQEEIK-SLTKERDNLKTIKEALEVKHDQLKEHIR 1373
Query: 1145 KEIETLKQAAAQKSQQLSALQEEN--VKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEM 1202
+ + ++++ +++ Q L+ +++N K+ E+ + + + ++ ++E E L+ +L E
Sbjct: 1374 ETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQES 1433
Query: 1203 KKRESKFIKDADE----------EKASLQKSIS--ITSALLTEKD--------AELEKLR 1242
K+ D+ E L+++I + L TE++ E E+
Sbjct: 1434 HDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETI 1493
Query: 1243 NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNL-ELQLKENKRQLS--SSSGNTDT 1299
NE+ V E + + ++ + LE+ KL+ K++ + E + + N +Q+S N
Sbjct: 1494 NELRVNLSEKET--EISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELK 1551
Query: 1300 QADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1336
Q E +A++S + + S +++L + Q+ + ++++M
Sbjct: 1552 QFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM 1588
Score = 117 bits (294), Expect = 6e-26
Identities = 195/955 (20%), Positives = 406/955 (42%), Gaps = 77/955 (8%)
Query: 352 ALQEALKEKQQHIEQLLAE---RDLERAEVAKATS-HVGEIEQELALARDGHDQHVLELE 407
+++E LK ++ +++ L E RDLE+ E K H+ E ++ + R + E+
Sbjct: 1693 SVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEIS 1752
Query: 408 AKMDQLRTMVEAADREKVELLNQL-------EEEKRKVEDLQFRVEEESITKGDLETQTK 460
L +A + +++ +L +E++ ++ L+ V E++ +++ +
Sbjct: 1753 NMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLE 1812
Query: 461 LEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRR 520
+A+++E Q L + + L++++ +T+ VSE ++ + KD +L + ++ E+
Sbjct: 1813 NSNAKLQEKIQELKANEHQLITLKKDVNETQ-KKVSEMEQLKKQIKDQSLTLSKL-EIEN 1870
Query: 521 RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKAL 580
+ K +++ S+++E +L+ E + + + SL+E AR+ Q+E+K
Sbjct: 1871 LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQET-KARDLEIQQELKTA 1929
Query: 581 YTATEKLSKENESLKSKLEHANKENSDV---IALWKSKLETAIASHQQA-MEELKVSFSK 636
+++ + + L+ K+ + SD+ + K +L+ I Q+ ++ L+V
Sbjct: 1930 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989
Query: 637 GLGTETA-EFAELKTQIEKMRLDYQH-EIENLQ-----NQQDSERAAHAKEMEALRAKLM 689
+ + E +LK Q E L Q ++N Q ++ E AKE + LR
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE 2049
Query: 690 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 749
+ E++ + +R + + H V+ E L + + E L+ KC+ +++
Sbjct: 2050 SLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLT----ESLREKCSRIKELLK 2105
Query: 750 NFTSQLKATEEKL--LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 807
+ S++ E L L LD L K K +++ L Q KH IEK +++
Sbjct: 2106 RY-SEMDDHYECLNRLSLD-LEKEIEFQKELSMRVKANLSLPYLQTKH--IEKLFTANQR 2161
Query: 808 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 867
S+ ++LK LS V+++KE + + + F + E+ +E +
Sbjct: 2162 CSMEFHRIMKKLKYV-----LSYVTKIKEEQHESINKFEMDFIDEVEK-------QKELL 2209
Query: 868 NKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE--KDEREEQLIKAKEKLENDIAEIMKM 925
K+ ++ ++ S +L L+ N +M+ E KD E + K + + ++
Sbjct: 2210 IKIQHLQQDCDVPSRELRDLKLN-QNMDLHIEEILKDFSESEFPSIKTEFQQVLS----- 2263
Query: 926 SGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 985
N ++T+ +E D+E+L+ + K N+ + + + E ++
Sbjct: 2264 ---NRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEER 2320
Query: 986 HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTED 1045
KE E+ L L++K E Q LK T + +N T T+
Sbjct: 2321 SATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN--KNPHVTSRATQL 2378
Query: 1046 KLKGAREENSGLLQELEE-LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQT 1104
+ RE + L + E + K++ K + E I+ ++ + E+ LE TK+T
Sbjct: 2379 TTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKET 2438
Query: 1105 NAKLQNELDTLKENNLKNVEELNKSKELLTVENQK-MEEFRKEIETLKQAAAQKSQQLSA 1163
LQ+++ + + +E+L + +E K +EF KEI K A + +++
Sbjct: 2439 IQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATK-ATVEYQKEVIR 2497
Query: 1164 LQEENVKLAEE------LGRSRDEVTSHQKLE---EERSVLNNQLLEMKKRESKFIKDAD 1214
L EN++ +++ + D S++ L V N + L +K + K+
Sbjct: 2498 LLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEIS 2557
Query: 1215 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDK 1269
+ K ++ I + LL+ + L NEV + E + H V S K
Sbjct: 2558 KLKQQNEQLIKQKNELLSNN----QHLSNEVKTWK-ERTLKREAHKQVTCENSPK 2607
Score = 110 bits (275), Expect = 1e-23
Identities = 184/912 (20%), Positives = 382/912 (41%), Gaps = 145/912 (15%)
Query: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
+QE L+ H+++ D R V++ T + ++++L + + + EL+A Q
Sbjct: 1772 IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ 1831
Query: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQT-----KL------ 461
L T+ + +N+ +++ ++E L+ +++++S+T LE + KL
Sbjct: 1832 LITLKKD--------VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEE 1883
Query: 462 ------EHARIKELEQSLLFEK---------TKADKL--QRELEDTRVATVSEKSRIMEL 504
E ++ +E++L E+ TKA L Q+EL+ R+ + K + +L
Sbjct: 1884 MKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKL 1943
Query: 505 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ-REITSLK 563
+ ++ + +++++++ L+ +K + +E+ L+ K +V + + E+ LK
Sbjct: 1944 REKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLK 2003
Query: 564 EHFGAREETHQKEIKALYTATEKL----------SKENESLKSKLEHANKENSDVIALWK 613
+ F A+ + Q + T+KL +KE + L+ E E IA +
Sbjct: 2004 KQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLR 2063
Query: 614 SKLETAIASHQQAMEELKVSFSKGLGTETAE------------FAELKTQIE---KMRLD 658
+ +HQ E+ +S + TE+ ++E+ E ++ LD
Sbjct: 2064 EMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLD 2123
Query: 659 YQHEIENLQNQQDSERA------AHAKEMEALRA----------KLMKVIKEKENSLEAI 702
+ EIE + +A K +E L ++MK +K + + I
Sbjct: 2124 LEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKI 2183
Query: 703 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKL 762
+ + ++ ++ ++ D + K +E IK++ L Q C+ ++ + + LK +
Sbjct: 2184 KEEQHESINKFEMDFIDEVEKQKELLIKIQHL---QQDCDVPSRELRD----LKLNQNMD 2236
Query: 763 LDLDALRKASSEGK------------SEMKKLRQQLEAAEKQIKHLEIEKNA---ESSKA 807
L ++ + K SE + S K++ Q LE +E KN E+ +
Sbjct: 2237 LHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRI 2296
Query: 808 SSITRELQGRELKLTNLQENLSEVSQ-VKETLEKELQILKEKFAEASEEAVSVQRSMQE- 865
+ R + + N E S + + E++L+ LKEK + + +++ S+
Sbjct: 2297 CQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASG 2356
Query: 866 -TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDE----REEQLIKAKEKLE--ND 918
VN Q + ++ S + E + ++E E E +E ++IK +++LE ND
Sbjct: 2357 AQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTND 2416
Query: 919 IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS 978
I I K+ K+++ + E+ E +Q+ K A ++ IED+ +K +
Sbjct: 2417 I--IAKLQA-------KVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKI 2467
Query: 979 QQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQK 1038
E K +E +KE+ + +E + E + L+ + + ++H + Q K
Sbjct: 2468 DLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD-PQPSNK 2526
Query: 1039 TLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL 1098
L SG++Q + L +++ + + Q EQ+ K+K E L++
Sbjct: 2527 PL---------TCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSN- 2576
Query: 1099 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKS 1158
N L NE+ T KE LK ++ + +T EN K + A+ +K
Sbjct: 2577 ------NQHLSNEVKTWKERTLK-----REAHKQVTCENSP-----KSPKVTGTASKKKQ 2620
Query: 1159 QQLSALQEENVK 1170
S +E N++
Sbjct: 2621 ITPSQCKERNLQ 2632
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 184 bits (468), Expect = 4e-46
Identities = 235/1039 (22%), Positives = 480/1039 (46%), Gaps = 120/1039 (11%)
Query: 291 AKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGT 350
A+ A +R + + LK+ L+ ++ V + ++ LTE + I+
Sbjct: 938 AELTAKKRKLEDECSELKKDIDDLELT-LAKVEKEKHATENKVKNLTEEMAGLDETIAKL 996
Query: 351 TALQEALKEK-QQHIEQLLAERDLERAEVAKATSHV--------GEIEQELALARD-GHD 400
T ++AL+E QQ ++ L E D + KA + + G +EQE L D
Sbjct: 997 TKEKKALQEAHQQTLDDLQMEEDKVNT-LTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA 1055
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTK 460
+ LE + K+ Q TM + +K +L +L++++ ++ +LQ ++E+E L+ + K
Sbjct: 1056 KRKLEGDLKLAQESTM--DTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIK 1113
Query: 461 LEHARIKELEQSLLFEKTKADKLQRELED--TRVATVSEK--------SRIMELEKDLAL 510
ARI+ELE+ + E+ K +++ D + +SE+ S +E+ K
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK--- 1170
Query: 511 RVQEVAELRRRLESNKPAGD----------VDMSLSLLQEISSLQ---EKLEVTRTDHQR 557
R E ++RR LE + + D L ++I SLQ +KLE +++ +
Sbjct: 1171 REAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKM 1230
Query: 558 EITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE 617
EI L + + K T ++LS+ +K+K E + +++ A K++L
Sbjct: 1231 EINDLASNMETVSKAKANFEKMCRTLEDQLSE----IKTKEEEQQRLINELSA-QKARLH 1285
Query: 618 TAIASHQQAMEE---LKVSFSKGLGTETAEFAELKTQIE---KMRLDYQHEIENLQNQQD 671
T + ++E + S+G T + ELK Q+E K + H +++ ++ D
Sbjct: 1286 TESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCD 1345
Query: 672 SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL-QEAEIK 730
R + +E EA +A+L + + + + + R+K + Q E+E+ KL Q +
Sbjct: 1346 LLREQYEEEQEA-KAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA 1404
Query: 731 VKELEVLQAKCN--EQTK-----VIDNFTSQLKATEEKLLDLDALR----KASSEGKSEM 779
+ +E + +KC E+TK +++ ++ + + LD + K +E K +
Sbjct: 1405 EEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKY 1464
Query: 780 KKLRQQLEAAEKQIKHLEIE----KNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 835
++ + +LEA++K+ + L E KNA + E RE K NLQ+ +S++++
Sbjct: 1465 EETQAELEASQKESRSLSTELFKVKNAYEESLDHL--ETLKRENK--NLQQEISDLTEQI 1520
Query: 836 ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADME 895
K + L++ + E +Q S++E L +E + + +L +++ ++++
Sbjct: 1521 AEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVK---SEID 1577
Query: 896 AKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK---ERDVEELQL 952
K EKDE +QL + N + + M +++ ND LR+K E D+ E+++
Sbjct: 1578 RKIAEKDEELDQLKR------NHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEI 1631
Query: 953 KLTKANENASFLQKSIEDM--TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQ 1010
+L AN A+ +++ + +K Q + A + +++ KE +L+ +E++ +
Sbjct: 1632 QLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKE---QLAMVERRANLMQAE 1688
Query: 1011 CQELKARYERATSETKTKHEEILQNLQK---------TLLDTEDKLKGAREENSGLLQEL 1061
+EL+A ER K +E+L ++ +L++T+ KL+ + G ++++
Sbjct: 1689 VEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748
Query: 1062 -EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL 1120
+E R +KAK A T DA + E++ KE+ +T A LE K +N T+K+ L
Sbjct: 1749 VQEARNAEEKAKKAIT--DAAMMAEELKKEQ-DTSAHLERMK------KNMEQTVKDLQL 1799
Query: 1121 KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1180
+ L+++++L ++ +K+I+ L+ + ++ + Q+ NV+ + L +
Sbjct: 1800 R----LDEAEQL------ALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHER 1849
Query: 1181 EV--TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAEL 1238
V ++Q E+ +++L Q L K + E+A Q ++++ + + E
Sbjct: 1850 RVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEE 1909
Query: 1239 EKLRNEVTVLRGENASAKS 1257
K R ++ + KS
Sbjct: 1910 AKERADIAESQVNKLRVKS 1928
Score = 158 bits (400), Expect = 3e-38
Identities = 222/1052 (21%), Positives = 460/1052 (43%), Gaps = 147/1052 (13%)
Query: 387 EIEQELALARDGHDQHVLEL---EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQF 443
E E+E+A ++ ++ EL EAK +L + +EK +L Q++ E + D +
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 444 RVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIME 503
R ++ TK LE + K E E E+ + E T +R+LED E S + +
Sbjct: 908 RCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELTAK---KRKLED-------ECSELKK 956
Query: 504 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 563
DL L + +V E + NK + L + I+ L ++ + + HQ+ + L
Sbjct: 957 DIDDLELTLAKV-EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL- 1014
Query: 564 EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASH 623
+ + ++ L A KL ++ + L+ LE K D + K KLE
Sbjct: 1015 -------QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMD-LERAKRKLE------ 1060
Query: 624 QQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEA 683
+LK++ + TE K Q+ + + E+ NLQ + + E+A A +++
Sbjct: 1061 ----GDLKLAQESTMDTEND-----KQQLNEKLKKKEFEMSNLQGKIEDEQAL-AIQLQK 1110
Query: 684 LRAKLMKVIKEKENSLEAIRSKLDKAEDQH---LVEMEDTLNKLQEA----EIKVKELEV 736
+L I+E E +EA R+ KAE Q E+E+ +L+EA +++ +
Sbjct: 1111 KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1170
Query: 737 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEM----KKLRQQLEAAEKQ 792
+A+ + + ++ T Q +AT ALRK ++ +E+ L++ + EK+
Sbjct: 1171 REAEFQKMRRDLEESTLQHEATAA------ALRKKHADSVAELGEQIDSLQRVKQKLEKE 1224
Query: 793 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 852
L++E N +S ++++ E L++ LSE+ +E ++ + L + A
Sbjct: 1225 KSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARL 1284
Query: 853 SEEAVSVQRSMQE---TVNKLHQKEEQF------------------NMLSSDLEKLRENL 891
E+ R + E V++L + ++ F + L+ L+ R +
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDC 1344
Query: 892 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK-------- 943
+ ++ E+ E + +L + K +++A+ ++ Q T+ +E + K
Sbjct: 1345 DLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA 1404
Query: 944 ERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKK 1003
E VE + K + LQ +ED+ + E+S A +++++ ++ L++ ++K
Sbjct: 1405 EEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERS-NAACIALDKKQRNFDKVLAEWKQK 1463
Query: 1004 METSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEE 1063
E E +A E + E+++ E+ + ++ ++ D L+ + EN L QE+ +
Sbjct: 1464 YE-------ETQAELEASQKESRSLSTELFK-VKNAYEESLDHLETLKRENKNLQQEISD 1515
Query: 1064 LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK--------------------- 1102
L +Q A+ + + ++ +Q+ EK+E SLE+ +
Sbjct: 1516 LTEQI--AEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVK 1573
Query: 1103 ----QTNAKLQNELDTLKENNLKNVE--------ELNKSKELLTVENQKMEEFRKEIE-T 1149
+ A+ ELD LK N+L+ VE E+ + L ++ +KME E+E
Sbjct: 1574 SEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIK-KKMEGDLNEMEIQ 1632
Query: 1150 LKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKF 1209
L A Q ++ L L+ L + D + L+E QL +++R +
Sbjct: 1633 LNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKE-------QLAMVERRANLM 1685
Query: 1210 IKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDK 1269
+ +E +ASL++ T + EL V +L +N SL + + LE+D
Sbjct: 1686 QAEVEELRASLER----TERGRKMAEQELLDASERVQLLHTQNT---SLINTKKKLETDI 1738
Query: 1270 VKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDL 1329
+++ +++++ + + + + + + A+E ++ Q++ L + ++++ +DL
Sbjct: 1739 SQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNMEQTVKDL 1797
Query: 1330 KMKVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1361
+++++ + AL G + ++ +E +S+
Sbjct: 1798 QLRLDEAEQLALKGGKKQIQKLEARVRELESE 1829
Score = 99.8 bits (247), Expect = 2e-20
Identities = 160/724 (22%), Positives = 308/724 (42%), Gaps = 96/724 (13%)
Query: 287 TPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARK 346
T +KAKAN ++ T L S + + + +S++ +R L S ++R+
Sbjct: 1241 TVSKAKAN-FEKMCRTLEDQL--SEIKTKEEEQQRLINELSAQKAR---LHTESGEFSRQ 1294
Query: 347 ISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLEL 406
+ A+ L +Q Q + E + E KA S + AL HD
Sbjct: 1295 LDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAH-----ALQSARHD------ 1343
Query: 407 EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD-LETQTKLEHAR 465
D LR E K EL + + +V + + E ++I + + LE K R
Sbjct: 1344 ---CDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400
Query: 466 IKELEQSL--------LFEKTKADKLQRELEDTRV-------ATVSEKSRIMELEKDLAL 510
+++ E+ + EKTK +LQ E+ED + A ++ + +K LA
Sbjct: 1401 LQDAEEHVEAVNSKCASLEKTK-QRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAE 1459
Query: 511 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRT------DHQREITSLKE 564
Q+ E + LE+++ +S L + ++ +E L+ T + Q+EI+ L E
Sbjct: 1460 WKQKYEETQAELEASQKESR-SLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTE 1518
Query: 565 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANK----ENSDVIALW------KS 614
K I L ++L E L++ LE A E ++ + KS
Sbjct: 1519 QIAEGG----KHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKS 1574
Query: 615 KLETAIASHQQAMEELKVSFSKGLGTETAEF-AELKTQIEKMRLDYQHEIENLQNQQDSE 673
+++ IA + +++LK + + + + + AE++++ + +R+ + E +L +
Sbjct: 1575 EIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKME-GDLNEMEIQL 1633
Query: 674 RAAHAKEMEALR--AKLMKVIKEKENSLE-AIRSKLDKAEDQHLVEMEDTLNKLQEAEI- 729
A+ + EALR ++K+ + L+ AIR + D E +VE L + + E+
Sbjct: 1634 NHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELR 1693
Query: 730 ----------KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKL-LDLDALRKASSEGKSE 778
K+ E E+L A +E+ +++ + L T++KL D+ ++ + E
Sbjct: 1694 ASLERTERGRKMAEQELLDA--SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQE 1751
Query: 779 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK-ET 837
+ ++ + A + E E ++ + R + E + +LQ L E Q+ +
Sbjct: 1752 ARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKG 1811
Query: 838 LEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADME-- 895
+K++Q L+ + E E S Q+ E V L + E + L+ E+ R+N+ ++
Sbjct: 1812 GKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDL 1871
Query: 896 ---------AKFREKDEREEQL---IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 943
A R+ +E EEQ + KL++++ E + + SQ+ K LR+K
Sbjct: 1872 VDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNK----LRVK 1927
Query: 944 ERDV 947
R+V
Sbjct: 1928 SREV 1931
Score = 54.7 bits (130), Expect = 6e-07
Identities = 64/265 (24%), Positives = 107/265 (40%), Gaps = 32/265 (12%)
Query: 1105 NAKLQNELDTLKENNLKNVEELNKSK-----------ELLTVENQKMEEFRKEIETLKQA 1153
+A+ + E+ +KE K EEL K++ L+ +N + + E + L A
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADA 905
Query: 1154 AAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDA 1213
+ Q + + K+ E R+ DE + +L ++ L ++ E+KK I D
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD----IDDL 961
Query: 1214 DEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLH-----------SVV 1262
+ A ++K T + E+ L + L E + + H V
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKV 1021
Query: 1263 QTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDL 1322
TL K KLE +V +LE L++ K+ + + AQES +D N D
Sbjct: 1022 NTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEN----DK 1077
Query: 1323 QRKNQDLKMKVEMMSEAALNGNGDD 1347
Q+ N+ LK K MS L G +D
Sbjct: 1078 QQLNEKLKKKEFEMSN--LQGKIED 1100
Score = 35.8 bits (81), Expect = 0.30
Identities = 33/136 (24%), Positives = 62/136 (45%), Gaps = 10/136 (7%)
Query: 352 ALQEALKEKQQHIEQLLAE-RDLERAEVAKATSHVGEIE---------QELALARDGHDQ 401
A Q ALK ++ I++L A R+LE ++ +V ++ +EL + +
Sbjct: 1804 AEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRK 1863
Query: 402 HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKL 461
++L L+ +D+L+T V+A R+ E Q K LQ +EE E+Q
Sbjct: 1864 NILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNK 1923
Query: 462 EHARIKELEQSLLFEK 477
+ +E+ ++ E+
Sbjct: 1924 LRVKSREVHTKVISEE 1939
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 184 bits (466), Expect = 7e-46
Identities = 231/1028 (22%), Positives = 460/1028 (44%), Gaps = 149/1028 (14%)
Query: 295 AVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQ 354
A +R + +SLKR L+ ++ V + ++ L+E + IS T +
Sbjct: 942 AKKRNLEDKCSSLKRDIDDLELT-LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEK 1000
Query: 355 EALKEK-QQHIEQLLAERDLER------AEVAKATSHV-GEIEQELALARD-GHDQHVLE 405
++L+E QQ ++ L E D A++ + T + G +EQE L D + LE
Sbjct: 1001 KSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE 1060
Query: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHAR 465
+ KM Q M D++++E +L++++ ++ LQ ++++E + + + K AR
Sbjct: 1061 GDLKMSQESIMDLENDKQQIE--EKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQAR 1118
Query: 466 IKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLE-- 523
I+ELE+ + E T K++++ DLA ++E++E RLE
Sbjct: 1119 IEELEEEIEAEHTLRAKIEKQ------------------RSDLARELEEISE---RLEEA 1157
Query: 524 SNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTA 583
S + ++M+ E ++ LE H+ +L++ ++I L
Sbjct: 1158 SGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRV 1217
Query: 584 TEKLSKENESLK-------SKLEHANKENSDV---------------------------I 609
+KL KE LK S +E +K S++ +
Sbjct: 1218 KQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDL 1277
Query: 610 ALWKSKLETA---IASHQQAMEELKVSFSKGLGTETAEFAELKTQIE---KMRLDYQHEI 663
+ K++L+T ++ + E L +K T + ELK Q+E K + H +
Sbjct: 1278 NMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHAL 1337
Query: 664 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
++ ++ D R + +E EA +A+L + + + + + R+K + Q E+E+ K
Sbjct: 1338 QSSRHDCDLLREQYEEEQEA-KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396
Query: 724 L----QEAEIKVKELEVLQAKCN--EQTKV-----IDNFTSQLKATEEKLLDLDALR--- 769
L QEAE + E +KC E+TK +++ L+ + LD +
Sbjct: 1397 LAQRLQEAE---ENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNF 1453
Query: 770 -KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 828
K +E K ++ + + +LEAA+K+ + L E + + +L+ + NLQE +
Sbjct: 1454 DKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEI 1513
Query: 829 SEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLR 888
S++++ K LQ ++ +E +Q +++E L +E + + +L +++
Sbjct: 1514 SDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVK 1573
Query: 889 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK---ER 945
++++ K EKDE EQL + ++ + ++ +++ ND LRLK E
Sbjct: 1574 ---SELDRKVIEKDEEIEQLKRNSQRAAEALQSVL------DAEIRSRNDALRLKKKMEG 1624
Query: 946 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ---QEAAKKHEEEKKELERKLSDLEK 1002
D+ E++++L +N + QK + + + + SQ +A + +E +L+ +L+ +E+
Sbjct: 1625 DLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNE----DLKEQLAIVER 1680
Query: 1003 KMETSHNQCQELKARYERATSETKTKHEE---------ILQNLQKTLLDTEDKLKG---- 1049
+ + +E+K E+ + +E +L + +L++T+ KL+
Sbjct: 1681 RNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQ 1740
Query: 1050 --AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK----Q 1103
A ENS ++E R +KAK A T DA + E++ KE+ +T A LE K Q
Sbjct: 1741 CQAEVENS-----IQESRNAEEKAKKAIT--DAAMMAEELKKEQ-DTSAHLERMKKNLEQ 1792
Query: 1104 TNAKLQNELDTLKENNL----KNVEEL-NKSKEL---LTVENQKMEEFRKEIETLKQAAA 1155
T LQ+ LD ++ L K +++L N+ +EL L VE ++ E K ++
Sbjct: 1793 TVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVK 1852
Query: 1156 QKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADE 1215
+ + Q + ++L + + + + +V S+++ EE N L +R +++A
Sbjct: 1853 EMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEA-A 1911
Query: 1216 EKASLQKS 1223
E+A + +S
Sbjct: 1912 ERADIAES 1919
Score = 169 bits (429), Expect = 1e-41
Identities = 218/1030 (21%), Positives = 441/1030 (42%), Gaps = 103/1030 (10%)
Query: 387 EIEQELALARDGHDQHVLEL---EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQF 443
E E+E+A ++ ++ EL EA+ +L + + +EK +L Q++ E + D +
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEE 907
Query: 444 RVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKL---QRELEDTRVATVSEKSR 500
R E G ++++ LE A++KEL + L E+ +L +R LED + S
Sbjct: 908 RCE------GLIKSKILLE-AKVKELTERLEEEEEMNSELVAKKRNLED-------KCSS 953
Query: 501 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 560
+ DL L + +V E + NK + +L + IS L ++ + + HQ+ +
Sbjct: 954 LKRDIDDLELTLTKV-EKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLD 1012
Query: 561 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAI 620
L + + ++ L KL ++ + L+ LE K +D + K KLE +
Sbjct: 1013 DL--------QVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRAD-LERAKRKLEGDL 1063
Query: 621 ASHQQAMEEL---KVSFSKGLGTETAEFAELKTQIEKMR---LDYQHEIENLQNQQDSER 674
Q+++ +L K + L + E ++L+ +I+ + L +Q +I+ LQ + + E
Sbjct: 1064 KMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIE-EL 1122
Query: 675 AAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKEL 734
+ LRAK+ K + LE I +L++A ++E +NK +EAE +
Sbjct: 1123 EEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIE--MNKKREAEFQKMRR 1180
Query: 735 EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD-------ALRKASSEGKSEMKKLRQQLE 787
++ +A + Q + E +D L K SE K E+ + +E
Sbjct: 1181 DLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIE 1240
Query: 788 AAEKQIKHLE----------IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 837
A K ++E E A+ + + + +L ++ +L LS + KE+
Sbjct: 1241 ALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKES 1300
Query: 838 LEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAK 897
L +L K+ + EE ++R M+E + D + LRE +
Sbjct: 1301 LISQLTKSKQALTQQLEE---LKRQMEEETKAKNAMAHALQSSRHDCDLLRE-------Q 1350
Query: 898 FREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK-ERDVEELQLKLTK 956
+ E+ E + +L +A K +++A+ ++ Q T+ +E + K + ++E +
Sbjct: 1351 YEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTET 1410
Query: 957 ANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA 1016
AN + L+K+ + + + E ++ + H L++K + +K + + E +A
Sbjct: 1411 ANSKCASLEKTKQRLQGEVEDLMRDLERSH-TACATLDKKQRNFDKVLAEWKQKLDESQA 1469
Query: 1017 RYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ-ADKAKAAQ 1075
E A E+++ E+ + ++ + D+L+ R EN L +E+ +L +Q A+ K Q
Sbjct: 1470 ELEAAQKESRSLSTELFK-MRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQ 1528
Query: 1076 TAEDAMQIMEQMTKE----KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1131
AE +++EQ + E SLE + ++Q EL +K + V E ++ E
Sbjct: 1529 EAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIE 1588
Query: 1132 LLTVENQKMEE-----FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQ 1186
L +Q+ E EI + A K + L E ++L R E H
Sbjct: 1589 QLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHS-NRQMAETQKHL 1647
Query: 1187 KLEE---------------ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALL 1231
+ + L QL +++R +++ +E K +L++ T
Sbjct: 1648 RTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQ----TERTR 1703
Query: 1232 TEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLS 1291
+ EL + V +L +N SL + + LE+D + + +V+N +Q N + +
Sbjct: 1704 RLSEQELLDASDRVQLLHSQNT---SLINTKKKLEADIAQCQAEVEN-SIQESRNAEEKA 1759
Query: 1292 SSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNY 1351
+ E+ + ++ L + +L++ +DL+ +++ + AL G +
Sbjct: 1760 KKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL 1819
Query: 1352 DSDDQEKQSK 1361
++ +E +++
Sbjct: 1820 ENRVRELENE 1829
Score = 158 bits (400), Expect = 3e-38
Identities = 157/702 (22%), Positives = 314/702 (44%), Gaps = 78/702 (11%)
Query: 692 IKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNF 751
IK S EA + ED + E ++ + E++ K + +LQ K + Q +V +
Sbjct: 840 IKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQV-QSE 898
Query: 752 TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 811
T L EE+ + L K+ ++++K+L ++LE E+ L +K K SS+
Sbjct: 899 TENLMDAEERC---EGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLK 955
Query: 812 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH 871
R++ EL LT +++ + L +E+ L+E ++ ++E S+Q + Q+T++ L
Sbjct: 956 RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQ 1015
Query: 872 QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS 931
+E++ N L KL + D+E ++ + L +AK KLE D+ + D +
Sbjct: 1016 VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEN 1075
Query: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----- 986
++ ++L+ KE ++ +LQ K+ ++ QK I+++ + E+ ++E +H
Sbjct: 1076 DKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAK 1135
Query: 987 -EEEKKELERKLSDLEKKMETSH---------NQCQELK-ARYERATSETKTKHEEILQN 1035
E+++ +L R+L ++ +++E + N+ +E + + R E +HE
Sbjct: 1136 IEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1195
Query: 1036 LQKTLLDTEDKL-----------KGAREENSGLLQELEEL--------RKQADKAKAAQT 1076
L+K D+ +L + +E S L E++++ + +++ + +T
Sbjct: 1196 LRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRT 1255
Query: 1077 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1136
ED ++ +++T+ + L K EL E + +L KSK+ LT
Sbjct: 1256 VEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT-- 1313
Query: 1137 NQKMEEFRKEIETLKQA------AAQKS--------QQLSALQEENVKLAEELGRSRDEV 1182
Q++EE ++++E +A A Q S +Q QE +L L ++ EV
Sbjct: 1314 -QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372
Query: 1183 TS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1241
K E + +L E KK+ ++ +++A+E + + E+E L
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDL 1432
Query: 1242 RNEVTVLRGENASAKSLHSVVQTLES-----DKVKLELKVKNLELQLKENKRQLSSSSGN 1296
++ + H+ TL+ DKV E K K E Q + Q S S
Sbjct: 1433 MRDL----------ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRS-- 1480
Query: 1297 TDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
T+ + A E +D L + L+R+N++L+ ++ ++E
Sbjct: 1481 LSTELFKMRNAYEEVVDQLET----LRRENKNLQEEISDLTE 1518
Score = 98.2 bits (243), Expect = 5e-20
Identities = 150/674 (22%), Positives = 295/674 (43%), Gaps = 96/674 (14%)
Query: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397
E S R K S + L ++ + Q +E+L + + E + A +H AL
Sbjct: 1290 ELSHRVEEKESLISQLTKSKQALTQQLEELKRQME-EETKAKNAMAH--------ALQSS 1340
Query: 398 GHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD-LE 456
HD D LR E K EL L + +V + + E ++I + + LE
Sbjct: 1341 RHD---------CDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELE 1391
Query: 457 TQTKLEHARIKELEQSL--------LFEKTKADKLQRELED---------TRVATVSEKS 499
K R++E E++ EKTK +LQ E+ED T AT+ +K
Sbjct: 1392 EAKKKLAQRLQEAEENTETANSKCASLEKTK-QRLQGEVEDLMRDLERSHTACATLDKKQ 1450
Query: 500 RIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQE---KLEVTRTDH- 555
R +K LA Q++ E + LE+ + +S L + ++ +E +LE R ++
Sbjct: 1451 R--NFDKVLAEWKQKLDESQAELEAAQKESR-SLSTELFKMRNAYEEVVDQLETLRRENK 1507
Query: 556 --QREITSLKEHF---GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV-- 608
Q EI+ L E G + +K K + L E ++ LEH + V
Sbjct: 1508 NLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL 1567
Query: 609 -IALWKSKLETAIASHQQAMEELKVSFSKGL-GTETAEFAELKTQIEKMRLDYQHEIENL 666
++ KS+L+ + + +E+LK + + ++ AE++++ + +RL + ++E
Sbjct: 1568 ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRL--KKKMEGD 1625
Query: 667 QNQQDSERAAHAKEMEALRAKLMKV---IKEKENSLE-AIRSKLDKAEDQHLVEMED--T 720
N+ + + ++M + L V +K+ + L+ A+RS D E +VE +
Sbjct: 1626 LNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLL 1685
Query: 721 LNKLQEAEI---------KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKA 771
L +L+E ++ ++ E E+L A +++ +++ + + L T++KL + D + +
Sbjct: 1686 LEELEEMKVALEQTERTRRLSEQELLDA--SDRVQLLHSQNTSLINTKKKL-EAD-IAQC 1741
Query: 772 SSEGKSEMKKLRQQLEAAEKQIKHLEI---EKNAESSKASSITRELQGRELKLTNLQENL 828
+E ++ +++ R E A+K I + E E ++ + R + E + +LQ L
Sbjct: 1742 QAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1801
Query: 829 SEVSQVK---------------ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 873
E Q+ LE EL + +++ AEA + A +R ++E + +
Sbjct: 1802 DEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEED 1861
Query: 874 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 933
+ L ++KL+ + + + E +E+ + ++++++ E + + SQ+
Sbjct: 1862 HKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQV 1921
Query: 934 TKMNDELRLKERDV 947
K LR K RDV
Sbjct: 1922 NK----LRAKSRDV 1931
Score = 90.5 bits (223), Expect = 1e-17
Identities = 128/616 (20%), Positives = 269/616 (43%), Gaps = 109/616 (17%)
Query: 332 RTGLLTETSSRYARKI-----------SGTTALQEALKEKQQHIEQLLAERDLERAEVAK 380
RT L E + A+++ S +L++ + Q +E L+ RDLER+ A
Sbjct: 1386 RTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM--RDLERSHTAC 1443
Query: 381 ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK--------------VE 426
AT L + D+ + E + K+D+ + +EAA +E E
Sbjct: 1444 AT---------LDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEE 1494
Query: 427 LLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRE 486
+++QLE +R+ ++LQ + + +T+ ET L+ A + L E+ K+D LQ
Sbjct: 1495 VVDQLETLRRENKNLQEEISD--LTEQIAETGKNLQEAE----KTKKLVEQEKSD-LQVA 1547
Query: 487 LEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQE 546
LE+ + E+S+I+ ++ +L+ Q +EL R+ + E
Sbjct: 1548 LEEVEGSLEHEESKILRVQLELS---QVKSELDRK-------------------VIEKDE 1585
Query: 547 KLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 606
++E + + QR +L+ A + ++ +K+ + ++ +L H+N++ +
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSRNDALRL----KKKMEGDLNEMEIQLGHSNRQMA 1641
Query: 607 DVIALWKS----------KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMR 656
+ ++ L+ A+ S++ E+L + + G E E+K +E+
Sbjct: 1642 ETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRN-GLLLEELEEMKVALEQ-- 1698
Query: 657 LDYQHEIENLQNQQDSERAAHAKEMEALRAK-LMKVIKEKENSLEAIRSKLDKAEDQHLV 715
+ER E E L A ++++ + SL + KL+ Q
Sbjct: 1699 ---------------TERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQA 1743
Query: 716 EMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL----KATEEKLLDL-----D 766
E+E+++ + + AE K K+ A E+ K + ++ L K E+ + DL +
Sbjct: 1744 EVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1803
Query: 767 ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK-ASSITRELQGRELKLTNLQ 825
A + A GK +++KL ++ E ++ +E ++ AE+ K A R+++ +
Sbjct: 1804 AEQLALKGGKKQIQKLENRVRELENELD-VEQKRGAEALKGAHKYERKVKEMTYQAEEDH 1862
Query: 826 ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 885
+N+ + + + L+ +++ K + EA E+A + + ++L + E+ ++ S +
Sbjct: 1863 KNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVN 1922
Query: 886 KLRENLADMEAKFREK 901
KLR D+ ++ E+
Sbjct: 1923 KLRAKSRDVGSQKMEE 1938
Score = 48.9 bits (115), Expect = 3e-05
Identities = 70/327 (21%), Positives = 144/327 (44%), Gaps = 41/327 (12%)
Query: 1057 LLQELEELRKQADKAKAAQT-AEDAMQIMEQMT------KEKTETLAS-LEDTKQTNAKL 1108
L +++ L K A+ K T ED + E++ KE E + S L++ ++
Sbjct: 836 LFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQV 895
Query: 1109 QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQL----SAL 1164
Q+E + L + + E L KSK LL + +++ E +E E + K + L S+L
Sbjct: 896 QSETENLMDAE-ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSL 954
Query: 1165 QEE-------NVKLAEELGRSRDEVTSHQK----LEEERSVLNNQLLEMKKRESKFIKDA 1213
+ + K+ +E + ++V + + LEE S L + +++ + + D
Sbjct: 955 KRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDL 1014
Query: 1214 DEEKASLQKSISITSALLTEKD------AELEKLRNEV-TVLRGENASAKSLHSVVQTLE 1266
E+ + I I + L + D + +KLR ++ R K + LE
Sbjct: 1015 QVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE 1074
Query: 1267 SDKVKLELKVKNLELQLKENKRQLSSSSGNT--------DTQADEDERAQESQIDFLNSV 1318
+DK ++E K+K E +L + + ++ ++ + QA +E E +I+ +++
Sbjct: 1075 NDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEE--LEEEIEAEHTL 1132
Query: 1319 IVDLQRKNQDLKMKVEMMSEAALNGNG 1345
++++ DL ++E +SE +G
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASG 1159
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 183 bits (465), Expect = 9e-46
Identities = 229/1006 (22%), Positives = 450/1006 (44%), Gaps = 105/1006 (10%)
Query: 295 AVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQ 354
A RR + LK+ L+ ++ + ++ LTE + ++ T +
Sbjct: 987 ARRRKLEDECTELKKDIDDLKLT-LAKAEKEKQATENKVKNLTEEMAALDESVARLTKEK 1045
Query: 355 EALKEK-QQHIEQLLAERDLERAEVAKATSHVGE--------IEQELALARDGHDQHVLE 405
+AL+E QQ + L AE D A + KA + + +EQE L D ++ +
Sbjct: 1046 KALQEAHQQALGDLQAEEDRVSA-LTKAKLRLEQQVEDLECSLEQEKKLRMDT-ERAKRK 1103
Query: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHAR 465
LE + + V A ++K +L +L+++ ++ L RVE+E + ++ + K AR
Sbjct: 1104 LEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQAR 1163
Query: 466 IKELEQSLLFEKT--------------KADKLQRELEDTRVATVSEKSRIMELEKDLALR 511
+ELE+ L E+ + ++L LE+ A+ ++ + E +L
Sbjct: 1164 AEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRL 1223
Query: 512 VQEVAELRRRLESNKPA---GDVDMSLSLLQEISSLQ---EKLEVTRTDHQREITSLKEH 565
+E+ E R E+ A + + L +++ SLQ +KLE +++ + E+ L +
Sbjct: 1224 RRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAAN 1283
Query: 566 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 625
K T ++LS+ K K+E ++ +D + + +L+T +
Sbjct: 1284 VETLTRAKASAEKLCRTYEDQLSE----AKIKVEELQRQLADA-STQRGRLQTESGELSR 1338
Query: 626 AMEE---LKVSFSKGLGTETAEFAELKTQIE---KMRLDYQHEIENLQNQQDSERAAHAK 679
+EE L S+G EL+ Q+E K + H ++ L++ D R H +
Sbjct: 1339 LLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEE 1398
Query: 680 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK----LQEAEIKVKELE 735
E EA +A+L +++ + + RSK + Q E+E+ K LQEAE + +E
Sbjct: 1399 EAEA-QAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAE---EGVE 1454
Query: 736 VLQAKCNEQTKV-------IDNFTSQLKATEEKLLDLDA----LRKASSEGKSEMKKLRQ 784
AKC+ K ++ T +L+ LD L +A E + + +++++
Sbjct: 1455 AANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQR 1514
Query: 785 QLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQI 844
+LEAA+++ + L E L+ + + NLQE +S+++ K +Q
Sbjct: 1515 ELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQE 1574
Query: 845 LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 904
L++ E +Q +++E L +E + + +L +++ A+++ K EKDE
Sbjct: 1575 LEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVK---AEVDRKLAEKDEE 1631
Query: 905 EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK---ERDVEELQLKLTKANENA 961
L + N + + ++ N+ LRLK E D+ +L+L+L A A
Sbjct: 1632 CANLRR------NHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQA 1685
Query: 962 SFLQKSIEDMTVKAEQSQQEAAKKHEEEK--KELERKLSDLEKKMETSHNQCQELKARYE 1019
+ Q + M Q ++E A + EE++ EL + LE++ + +EL+A E
Sbjct: 1686 TEAQAATRLMQA---QLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALE 1742
Query: 1020 RATSETKTKHEEILQNLQKT---------LLDTEDKLKGAREENSGLLQELEELRKQADK 1070
+ + +E+L+ ++ LL+ + KL+ + SG ++E + R++A++
Sbjct: 1743 QGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEE 1802
Query: 1071 AKAAQTAEDAMQIMEQMTKEKTETLASLEDTK----QTNAKLQNELDTLKENNL----KN 1122
KA + DA + E++ KE+ +T A LE K QT +LQ L+ ++ L K
Sbjct: 1803 -KAKKAITDAAMMAEELKKEQ-DTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQ 1860
Query: 1123 VEELN-KSKEL---LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRS 1178
V++L K +EL L E +K E K + ++ + + Q ++ ++ + + +
Sbjct: 1861 VQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKL 1920
Query: 1179 RDEVTSHQK-LEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1223
+ +V S+++ EE N L + +K + + D EE+A + ++
Sbjct: 1921 QSKVKSYKRQFEEAEQQANTNLAKYRKAQHEL--DDAEERADMAET 1964
Score = 160 bits (404), Expect = 1e-38
Identities = 222/1036 (21%), Positives = 442/1036 (42%), Gaps = 115/1036 (11%)
Query: 387 EIEQELALARD---GHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQF 443
+ E+ELA R G + EAK +L + +EK +L QL+ E+ + D +
Sbjct: 893 QAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEE 952
Query: 444 RVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIME 503
R +K LE ++KEL + L E +++ +L R E + + +
Sbjct: 953 RCHLLIKSKVQLE-------GKVKELSERLEDE----EEVNADLAARRRKLEDECTELKK 1001
Query: 504 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 563
DL L + + AE ++ NK + +L + ++ L ++ + + HQ+ + L
Sbjct: 1002 DIDDLKLTLAK-AEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDL- 1059
Query: 564 EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV----------IALWK 613
+ + + AL A +L ++ E L+ LE K D + L +
Sbjct: 1060 -------QAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQ 1112
Query: 614 SKLETAIASHQQAMEELKVSFSK--GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQD 671
+ A QQ E+LK S+ L + L Q++K + Q E L+ + +
Sbjct: 1113 ESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELE 1172
Query: 672 SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV 731
+ERAA RA++ K E LE + +L++A + E + +EAE+
Sbjct: 1173 AERAA--------RARVEKQRAEAARELEELSERLEEAGGASAGQREGC--RKREAELGR 1222
Query: 732 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEK 791
E+ +A + V Q + E +D+L++ + + E +LR +++
Sbjct: 1223 LRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAA 1282
Query: 792 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE----LQILKE 847
++ L K + + +L ++K+ LQ L++ S + L+ E ++L+E
Sbjct: 1283 NVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEE 1342
Query: 848 K---FAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 904
K ++ S +S++E +L ++ + + L+ ++ LR + + + E+ E
Sbjct: 1343 KECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEA 1402
Query: 905 EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDE------LRLKERD--VEELQLKLTK 956
+ +L + K ++A+ ++ Q T+ +E LRL+E + VE K +
Sbjct: 1403 QAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSS 1462
Query: 957 ANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA 1016
+ LQ ED+T++ E++ AA L++K LE+ +E Q +E++
Sbjct: 1463 LEKAKLRLQTESEDVTLELERATSAAA--------ALDKKQRHLERALEERRRQEEEMQR 1514
Query: 1017 RYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD-KAKAAQ 1075
E A E++ E+ + L+ + + L+ + EN L +E+ +L Q K+ Q
Sbjct: 1515 ELEAAQRESRGLGTELFR-LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQ 1573
Query: 1076 TAEDAMQIME------QMTKEKTETLASLEDTKQTNAKLQ----------------NELD 1113
E + +E Q E+ E LE+TK +L+ E
Sbjct: 1574 ELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECA 1633
Query: 1114 TLKENNLKNVEELNKSKELLTVENQKMEEFRKEIE--------TLKQAAAQKSQQLSALQ 1165
L+ N+ + VE L S + T + +K++E L A Q ++ +A +
Sbjct: 1634 NLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATR 1693
Query: 1166 EENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSIS 1225
+L EE RDE Q+L E L+ Q +++R S + +E +A+L++
Sbjct: 1694 LMQAQLKEEQA-GRDE---EQRLAAE---LHEQAQALERRASLLAAELEELRAALEQ--G 1744
Query: 1226 ITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKE 1285
S L E+ EL + + +L +N L + + LE+D +L +V+ + +E
Sbjct: 1745 ERSRRLAEQ--ELLEATERLNLLHSQNT---GLLNQKKKLEADLAQLSGEVEEAAQERRE 1799
Query: 1286 NKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNG 1345
+ + + + A+E ++ Q++ L + L++ ++L+ ++E +AAL G
Sbjct: 1800 AEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKTLEQTVRELQARLEEAEQAALRGGK 1858
Query: 1346 DDLNNYDSDDQEKQSK 1361
+ ++ +E +++
Sbjct: 1859 KQVQKLEAKVRELEAE 1874
Score = 137 bits (345), Expect = 7e-32
Identities = 179/825 (21%), Positives = 346/825 (41%), Gaps = 101/825 (12%)
Query: 336 LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEV-------------AKAT 382
L E S R + +E ++++ + +L R+LE A + A+
Sbjct: 1192 LEELSERLEEAGGASAGQREGCRKREAELGRL--RRELEEAALRHEATVAALRRKQAEGA 1249
Query: 383 SHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELL-------NQLEEEK 435
+ +GE L R ++ EL ++D L VE R K +QL E K
Sbjct: 1250 AELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAK 1309
Query: 436 RKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKA--------DKLQREL 487
KVE+LQ ++ + S +G L+T++ E +R+ E ++ L+ + ++ ++L+R+L
Sbjct: 1310 IKVEELQRQLADASTQRGRLQTESG-ELSRLLEEKECLISQLSRGKALAAQSLEELRRQL 1368
Query: 488 EDTRVATVSEKSRIMELEKDL-ALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQE 546
E+ A + + L D LR Q E + E + + E++ +
Sbjct: 1369 EEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANA------EVAQWRS 1422
Query: 547 KLEVTRTDHQREITSLKEHFGAREETHQKEIKA-------LYTATEKLSKENESLKSKLE 599
K E E+ K+ R + ++ ++A L A +L E+E + +LE
Sbjct: 1423 KYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELE 1482
Query: 600 HANKENSDVIALWKSK--LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRL 657
A S AL K + LE A+ ++ EE++ + L E L T++ ++R
Sbjct: 1483 RAT---SAAAALDKKQRHLERALEERRRQEEEMQ----RELEAAQRESRGLGTELFRLRH 1535
Query: 658 DYQHEIENLQ-----NQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKA--E 710
++ +E L+ N+ E + + +L K ++ +++ + +LE +S++ A E
Sbjct: 1536 GHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEE 1595
Query: 711 DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 770
+ +E+E+T + E+ + EV + + + + + +A E LDA +
Sbjct: 1596 AEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETR 1655
Query: 771 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 830
A +E KK+ L E Q+ H + + + +L+ + Q +E
Sbjct: 1656 ARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAE 1715
Query: 831 VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS-------D 883
+ + + LE+ +L + E +RS + +L + E+ N+L S
Sbjct: 1716 LHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQ 1775
Query: 884 LEKLRENLADMEAKFRE-KDEREEQLIKAKEKLEND--IAEIMKMSGDNSSQLTKMNDEL 940
+KL +LA + + E ER E KAK+ + + +AE +K D S+ L +M L
Sbjct: 1776 KKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTL 1835
Query: 941 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 1000
E+ V ELQ +L E+++Q A + +++ ++LE K+ +L
Sbjct: 1836 ---EQTVRELQARL---------------------EEAEQAALRGGKKQVQKLEAKVREL 1871
Query: 1001 EKKMET---SHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1057
E +++ H + + ++ER E + EE +NL + + D DKL+ +
Sbjct: 1872 EAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLAR-MQDLVDKLQSKVKSYKRQ 1930
Query: 1058 LQELEELRKQ--ADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1100
+E E+ A KA +DA + + + + A D
Sbjct: 1931 FEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRD 1975
Score = 99.8 bits (247), Expect = 2e-20
Identities = 137/600 (22%), Positives = 256/600 (42%), Gaps = 80/600 (13%)
Query: 749 DNFTSQLKATEEKL--LDLDALRKASSEGK--------SEMKKLRQQLEAAEKQIKHLEI 798
D F KATE+ L LDLD + K +++LR Q A K + L+
Sbjct: 782 DTFMDSRKATEKLLGSLDLDHTQYQFGHTKVFFKAGLLGVLEELRDQRLA--KVLTLLQA 839
Query: 799 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE-----------------TLEKE 841
+ R L GR+ T +Q N+ + VK E+E
Sbjct: 840 RSRGRLMRLE-YQRLLGGRDALFT-IQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEE 897
Query: 842 LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREK 901
L L+ + + + QE ++ N L+ L+ ++NLAD E
Sbjct: 898 LAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAE------ 951
Query: 902 DEREEQLIKAKEKLENDIAEIMK-------MSGDNSSQLTKMNDELRLKERDVEELQLKL 954
ER LIK+K +LE + E+ + ++ D +++ K+ DE ++D+++L+L L
Sbjct: 952 -ERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTL 1010
Query: 955 TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC-QE 1013
KA + + ++++T + + A+ +E +K ++ +H Q +
Sbjct: 1011 AKAEKEKQATENKVKNLTEEMAALDESVARLTKE------------KKALQEAHQQALGD 1058
Query: 1014 LKARYERATSETKTK--HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA 1071
L+A +R ++ TK K E+ +++L+ + L+ E KL+ E L+ +L +++
Sbjct: 1059 LQAEEDRVSALTKAKLRLEQQVEDLECS-LEQEKKLRMDTERAKRKLEGDLKLTQES--- 1114
Query: 1072 KAAQTAEDAMQIMEQMTK---EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1128
A A+D Q+ E++ K E ++ +ED + A++Q ++ L+ + EEL
Sbjct: 1115 -VADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA 1173
Query: 1129 SKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL 1188
+ ++ E +E+E L + + + +E K ELGR R E L
Sbjct: 1174 ERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRE------L 1227
Query: 1189 EEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVL 1248
EE + +++++++ + E+ SLQ+ +E E++ L V L
Sbjct: 1228 EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETL 1287
Query: 1249 RGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ---LSSSSGNTDTQADEDE 1305
ASA+ L +T E + ++KV+ L+ QL + Q L + SG +E E
Sbjct: 1288 TRAKASAEKL---CRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKE 1344
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 182 bits (463), Expect = 2e-45
Identities = 258/1062 (24%), Positives = 470/1062 (44%), Gaps = 185/1062 (17%)
Query: 354 QEALKEKQQHIEQLLAERDL----ERAEVAKATSHVGEIEQELALARDGHD--------- 400
++ALK++ +E LL ERD +A V + + E EL A D
Sbjct: 751 EKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT 810
Query: 401 ---------------QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRV 445
Q +L+LE + L V + +K ++ +L+ K +V+DL ++
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 870
Query: 446 E------EESITKGDLETQTKLEHARIKELEQS--LLFEKTKADKLQRELEDTRVATVSE 497
E E+ + ++KLE KE EQ+ +L EK RE + + +++
Sbjct: 871 EKQNSEMEQKVKSLTQVYESKLEDGN-KEQEQTKQILVEKENMILQMREGQKKEIEILTQ 929
Query: 498 KSRIME-----LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTR 552
K E L ++ + + + +++ + LL + + L+++LE T
Sbjct: 930 KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTA 989
Query: 553 TDHQREITSLKEHFGARE-ETHQKEIKALYTATEKL-SKENESLKSKLEHANKENSDVIA 610
E++ ++ F A+ E Q + A +L + + E ++S E +E +DVI+
Sbjct: 990 L----ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVIS 1045
Query: 611 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 670
+W+ KL +QQA EEL+ L + E AELK +I L + E E + +
Sbjct: 1046 IWEKKL------NQQA-EELQEIHEIQLQEKEQEVAELKQKI----LLFGCEKEEMNKEI 1094
Query: 671 DSERAAHAKEMEALRAKLMKVIKEKE---NSLEAIRSKLDKAEDQHLVEMEDTLNK-LQE 726
+ K+ L +L + +K+K NSL +KL HL ++E LNK L+E
Sbjct: 1095 TWLKEEGVKQDTTLN-ELQEQLKQKSAHVNSLAQDETKL----KAHLEKLEVDLNKSLKE 1149
Query: 727 AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS---EGKS-EMKKL 782
++L L+ E + + TS+LK T+E+ L + + S+ E KS E KKL
Sbjct: 1150 NTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
Query: 783 RQ----QLEAAEKQIKHLEIEK-----NAESSKASSITRELQGRELKLTNLQENLSEVSQ 833
+ QL+ K+ + L K N SSK ++I + + + T ++E L +
Sbjct: 1210 SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTC 1269
Query: 834 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 893
LE +L+ + +EE ++ S Q+ ++L +KE Q + +D+E L + +
Sbjct: 1270 TVSELEAQLR-------QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESL---VTE 1319
Query: 894 MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLK 953
EA +E +++ A + E+ I ++ K +N + +T M +EL+ K+ ++ L +
Sbjct: 1320 KEALQKEGGNQQQ----AASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQ 1375
Query: 954 LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET------- 1006
LT N LQ SI + E + K+++EEK EL ++ DL K++T
Sbjct: 1376 LTDLNVQ---LQNSIS--LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKIS 1430
Query: 1007 -------------------------SHNQCQELKARYERATSETKTKHEEILQNLQKTLL 1041
N +EL+ + E + E K E+I NL K L
Sbjct: 1431 ALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI--NLLKEEL 1488
Query: 1042 DTEDK----LKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLAS 1097
D ++K LKG E++ +++ E + K++ A+ E +E +KT + S
Sbjct: 1489 DQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIME-----LEDHITQKTIEIES 1543
Query: 1098 LEDT------------KQTNAKLQN--ELDTLKENNLKNVEELNKSKELLTVENQ----- 1138
L + K+ KLQ+ EL K+N +K EE ++LT+ENQ
Sbjct: 1544 LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEE-----KILTLENQVYSMK 1598
Query: 1139 -KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN 1197
++E +KE+E + + K ++L AL++ +L E E+ +K E++ + +
Sbjct: 1599 AELETKKKELEHVNLSVKSKEEELKALED---RLESESAAKLAEL--KRKAEQKIAAIKK 1653
Query: 1198 QLL-EMKKRESKFIKDADEEKASLQKSISITSA---LLTEKDAELEKLRNEVTVLRGENA 1253
QLL +M+++E ++ K + + L + +L EK +E ++E ++
Sbjct: 1654 QLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIV---PR 1710
Query: 1254 SAKSLHSVVQTLESD-----KVKLELKVKNLELQLKENKRQL 1290
SAK++ + + E+D + E K+ L+ L E ++ L
Sbjct: 1711 SAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLL 1752
Score = 150 bits (379), Expect = 8e-36
Identities = 211/998 (21%), Positives = 424/998 (42%), Gaps = 128/998 (12%)
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTK 460
+ +++ +M++ + E V L+ EK+K++ + + +++S+
Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLR--------- 187
Query: 461 LEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRR 520
RI EL + L ++ LQ E + A++ EK + + + + +V+ L++
Sbjct: 188 ----RIAELREELQMDQQAKKHLQEEFD----ASLEEKDQYISVLQT------QVSLLKQ 233
Query: 521 RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKAL 580
RL + M++ +L+ + L+ + EV + E G +K L
Sbjct: 234 RLRNGP------MNVDVLKPLPQLEPQAEVFTKEENPESD------GEPVVEDGTSVKTL 281
Query: 581 YTATEKLSKENESLKSKLE--HANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 638
T +++ ++ LK E ++KE ++ K L+ + Q +E++K
Sbjct: 282 ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEK 341
Query: 639 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 698
+ + K IE++ D I + Q +E+ LR+++ ++ + E
Sbjct: 342 TKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEEL 401
Query: 699 LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 758
E + K ++A + L + T K +EA K+K Q K E+T + + Q + +
Sbjct: 402 REQ-KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELS 460
Query: 759 EEKLLDLDALRKASSEGKSEMKKL-----------------------RQQLEAA--EKQI 793
K +D ++K+S E ++++KL ++Q++ A + Q
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS 520
Query: 794 KHLEIEKNAESSKASSITR-ELQGR------ELKLTNLQENL----SEVSQVKETLEKEL 842
++L+I + E ++ ++ ELQ + E KL +LQ+ + + +++ +LEK L
Sbjct: 521 EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL 580
Query: 843 QILK------------EKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN 890
Q K EK E V V++ E + HQ++ + + L+ L++
Sbjct: 581 QENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA---LWTEKLQVLKQQ 637
Query: 891 LADMEAKFREKDERE-EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949
K REK E+E E L+K KE + A I +M+ +L EL ++ E
Sbjct: 638 YQTEMEKLREKCEQEKETLLKDKEIIFQ--AHIEEMNEKTLEKLDVKQTELESLSSELSE 695
Query: 950 LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEK----KELERKLSDLEKKME 1005
+ K E S L+ + M + E E H+++ KE E + EK ++
Sbjct: 696 VLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK 755
Query: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
NQ + L ++ E H+ ++NL+ + +E +L+ A + Q +
Sbjct: 756 DQINQLELLLKERDKHLKE----HQAHVENLEADIKRSEGELQQA-SAKLDVFQSYQSAT 810
Query: 1066 KQADKAKAAQTAEDAMQIME------QMTKEKTETLASLED--TKQTNAKLQNELDTLKE 1117
+ KA Q A+ ++++ +TK+ E A +D T+ K+Q + D +++
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQ-DLMQQ 869
Query: 1118 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177
+N E K K L V K+E+ KE E KQ +K + ++E K E L +
Sbjct: 870 LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQ 929
Query: 1178 --SRDEVTSHQKLEEERSVLNNQLLEMKKRESK-------FIKDADEEKASLQKSISITS 1228
S E + H EE + NQ +M+K + K K +++A L+K + T+
Sbjct: 930 KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTA 989
Query: 1229 ALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNL-ELQLKENK 1287
L++K+ + +L A++ + V LE+++ + ++++L E+ +E
Sbjct: 990 LELSQKEKQF-----NAKMLEMAQANSAGISDAVSRLETNQKE---QIESLTEVHRRELN 1041
Query: 1288 RQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRK 1325
+S + QA+E + E Q+ + +L++K
Sbjct: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQK 1079
Score = 150 bits (378), Expect = 1e-35
Identities = 230/1072 (21%), Positives = 472/1072 (44%), Gaps = 169/1072 (15%)
Query: 308 KRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQL 367
K S S L + S+ S ++ E S +K+S A+Q + K+ E L
Sbjct: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT--EAL 1227
Query: 368 LAERDLERAEVAKATSHVGEIEQELALARDGHDQH---------------VLELEAKMDQ 412
L + E ++ + ++ L+R H QH V ELEA++ Q
Sbjct: 1228 LEAKTNELINISSSKTNA-------ILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQ 1280
Query: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQS 472
L + + +QLEE++ +++ + K D+E S
Sbjct: 1281 LTEEQNTLNISFQQATHQLEEKENQIKSM----------KADIE---------------S 1315
Query: 473 LLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVD 532
L+ EK + LQ+E + + A ++S I +L+K+L+ + V ++ L+ K V+
Sbjct: 1316 LVTEK---EALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKK----VE 1368
Query: 533 MSLSLLQEISSLQEKLE--VTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKE 590
+S SL ++++ L +L+ ++ ++ + I+SL++ + + +++ L + LSKE
Sbjct: 1369 IS-SLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKE 1427
Query: 591 NESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKT 650
S +++ + + S+ WK K ++ HQ ++EL++ L ++ A + +
Sbjct: 1428 KISALEQVDDWSNKFSE----WKKKAQSRFTQHQNTVKELQIQLE--LKSKEAYEKDEQI 1481
Query: 651 QIEKMRLDYQH--------EIENLQNQQDSERAAHAKEMEALRAKLMKV---IKEKENSL 699
+ K LD Q+ E+E+ +++ + + + E+++ A++M++ I +K +
Sbjct: 1482 NLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEI 1541
Query: 700 EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT- 758
E++ L Q +E ++ + KLQ + +E + + E+ ++N +KA
Sbjct: 1542 ESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAEL 1601
Query: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL---- 814
E K +L+ + + + E+K L +LE+ E K E+++ AE K ++I ++L
Sbjct: 1602 ETKKKELEHVNLSVKSKEEELKALEDRLES-ESAAKLAELKRKAEQ-KIAAIKKQLLSQM 1659
Query: 815 -QGRELKLTNLQENLSEVSQVKETLEKELQILKEKF--AEASE-EAVSVQRSMQETVNKL 870
+ E + +LSE++ + E+E+ IL+EK E+S+ E + V RS +
Sbjct: 1660 EEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYT 1719
Query: 871 HQKE------------EQFNMLSSDL---EKLRENLAD-----MEAKFREKDEREEQLIK 910
Q+E E+ ++L +L EKL + + + + F + + +E+LIK
Sbjct: 1720 EQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIK 1779
Query: 911 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 970
E E E M G +L + N + L + ++ + K N A +++ D
Sbjct: 1780 L-EHAEAKQHEDQSMIGHLQEELEEKNKKYSLIV--AQHVEKEGGKNNIQAKQNLENVFD 1836
Query: 971 MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERA--------- 1021
K Q ++ + E++ KEL+ S L ++ E + +EL ++YE+
Sbjct: 1837 DVQKTLQEKELTCQILEQKIKELD---SCLVRQKEVHRVEMEELTSKYEKLQALQQMDGR 1893
Query: 1022 ----------TSETKTKH---EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA 1068
T E H ++L N++ D E KL GA E L +E+ L+K
Sbjct: 1894 NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD- 1952
Query: 1069 DKAKAAQTAEDAMQIMEQMTKEKTETLASL--EDTKQTNAKLQNELDTLKENNLKNVEEL 1126
+ + KE + L L E ++ K++ E + L+ + +++L
Sbjct: 1953 ---------------LRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQL 1997
Query: 1127 NKSKELLTVENQKMEEFRKEI-ETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSH 1185
+E T QK +E I ET+ +A +++ L + QEE +L +++ D++
Sbjct: 1998 --MREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRT 2055
Query: 1186 QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV 1245
K EE +L+ + EM + ++D + LQK + + E + V
Sbjct: 2056 AKRYEE--ILDAREEEMTAK----VRDLQTQLEELQKKYQ------QKLEQEENPGNDNV 2103
Query: 1246 TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNT 1297
T++ + A+ +++ + + + ++ NLE +LK+ ++ + +++ T
Sbjct: 2104 TIMELQTQLAQKT-TLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGT 2154
Score = 135 bits (339), Expect = 4e-31
Identities = 190/910 (20%), Positives = 397/910 (43%), Gaps = 128/910 (14%)
Query: 285 STTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYA 344
+T + K N ++ + A + + + A+S + +T+ +
Sbjct: 1295 ATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAAS-----EKESCITQLKKELS 1349
Query: 345 RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404
I+ T ++E LKEK+ I L + ++ + S + E E ++ R +D+
Sbjct: 1350 ENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS-LSEKEAAISSLRKQYDEEKC 1408
Query: 405 ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVED----LQFRVEEESITKGDLETQTK 460
EL ++ L V+ +EK+ L Q+++ K + Q R + T +L+ Q +
Sbjct: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468
Query: 461 LEHARIKELEQSLLFEKTKADK-------LQRELEDTR-----------VATVSEKSRIM 502
L+ E ++ + K + D+ L+ E+ED + S+ +RIM
Sbjct: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM 1528
Query: 503 ELEKDLALRVQEVAELRRRLESNKPAGDVDMS--LSLLQEISSLQEKLEVTRTDHQREIT 560
ELE + + E+ L L++ D++ + LQ L E+ + + + +I
Sbjct: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Query: 561 SLKEH---FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE 617
+L+ A ET +KE++ + + + +E ++L+ +LE E++ +A K K E
Sbjct: 1589 TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLE---SESAAKLAELKRKAE 1645
Query: 618 TAIASHQQA----MEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSE 673
IA+ ++ MEE + + KG TE+ +EL T++++ + E+ L+ +
Sbjct: 1646 QKIAAIKKQLLSQMEEKEEQYKKG--TES-HLSELNTKLQER----EREVHILEEK---- 1694
Query: 674 RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEM--EDTLNKLQEAEIKV 731
K +E+ +++ + V + +N A ++ ++A+ Q V+ E+ ++ LQ +
Sbjct: 1695 ----LKSVESSQSETLIVPRSAKNV--AAYTEQEEADSQGCVQKTYEEKISVLQR-NLTE 1747
Query: 732 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEK 791
KE ++LQ E+ + + + +E+L+ L+ E +S + L+++LE K
Sbjct: 1748 KE-KLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNK 1806
Query: 792 QI-----KHLEIEKNAESSKASS--------ITRELQGRELKLTNLQENLSEVSQV---- 834
+ +H+E E + +A + + LQ +EL L++ + E+
Sbjct: 1807 KYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQ 1866
Query: 835 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLA-- 892
KE E++ L K+ + +A+ + L + E+ + KL N+
Sbjct: 1867 KEVHRVEMEELTSKYEKL--QALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQ 1924
Query: 893 --DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE--RDVE 948
D+E K + +++L K +L+ D+ + K L K D+ R ++ ++ E
Sbjct: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQE 1984
Query: 949 ELQLKL------------TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK 996
+L+LK T+ + L+ +I++ KA++ + E + H+EE +L +K
Sbjct: 1985 DLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKK 2044
Query: 997 LSDLEKKMETSHNQCQE-LKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1055
+++ + ++ + + +E L AR E T++ + + L+ LQK + KL+ +EEN
Sbjct: 2045 IAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQ-LEELQKKY---QQKLE--QEENP 2098
Query: 1056 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1115
G D + IME T+ +T + D+K + + ++ L
Sbjct: 2099 G---------------------NDNVTIMELQTQLAQKT-TLISDSKLKEQEFREQIHNL 2136
Query: 1116 KENNLKNVEE 1125
E+ LK E+
Sbjct: 2137 -EDRLKKYEK 2145
Score = 70.9 bits (172), Expect = 8e-12
Identities = 129/610 (21%), Positives = 240/610 (39%), Gaps = 126/610 (20%)
Query: 780 KKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLE 839
KKL+Q++ ++Q++ + A++S SS ++ R T E L E + +E+ +
Sbjct: 3 KKLKQKISEEQQQLQ--QALAPAQASSNSSTPTRMRSRTSSFT---EQLDEGTPNRESGD 57
Query: 840 KELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFR 899
+ K + S E++ + ++E++ + KE +S E L N D+++
Sbjct: 58 TQSFAQKLQLRVPSVESL-FRSPIKESLFRSSSKESLVR--TSSRESL--NRLDLDSSTA 112
Query: 900 EKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 959
D + +A++ + N +S ++ LR ER + + K ++
Sbjct: 113 SFDPPSDMDSEAEDLVGNS----------DSLNKEQLIQRLRRMERSLSSYRGKYSELVT 162
Query: 960 NASFLQKSIEDMTVKAEQSQQEA----------------AKKHEEEKKELERKLSDLEKK 1003
LQ+ + + QSQ ++ AKKH +E E + L + ++
Sbjct: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQE--EFDASLEEKDQY 220
Query: 1004 METSHNQCQELKARYERA---------------TSETKTKHE----------------EI 1032
+ Q LK R +E TK E +
Sbjct: 221 ISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKT 280
Query: 1033 LQNLQKTLLDTEDKLKGARE--------------ENSGL-------LQELEELR--KQAD 1069
L+ LQ+ + E+ LK +E E L LQELE+++ A+
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 1070 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNV----EE 1125
K K DA ++EQ+ ++K +A + +++ E + +K + EE
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 1126 LNKSKELLTVENQKMEEFRKEIETL-------KQAAAQKSQQLSAL----QEENVKLAEE 1174
L + KE E EE K + T ++ A+ +Q+ + +EE + L +E
Sbjct: 401 LREQKE--KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQE 458
Query: 1175 LGRSRDEVTSHQKLEEERSVLNNQLL---EMKKRESKFIKD--------ADEEKASLQKS 1223
L R + EV K E + Q L E+ ++E + K ++ K +L+KS
Sbjct: 459 LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKS 518
Query: 1224 ISITSALLTEKDAE----LEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNL 1279
S + EK+ + LE+L + + E S L + Q E+ + ++ +L
Sbjct: 519 QSEYLKISQEKEQQESLALEELELQKKAILTE--SENKLRDLQQEAETYRTRILELESSL 576
Query: 1280 ELQLKENKRQ 1289
E L+ENK Q
Sbjct: 577 EKSLQENKNQ 586
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 181 bits (458), Expect = 6e-45
Identities = 226/1037 (21%), Positives = 452/1037 (43%), Gaps = 128/1037 (12%)
Query: 364 IEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLE--LEAKMDQLRTMVEAAD 421
++ LL E +AK V E++LA + L+ L A+ QL+ ++A
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 422 R---EKVELLNQLEEEKRKVE----DLQFRVEEESITKGDLETQTKLEHARIKELEQSLL 474
E EL +L +K+++E DL+ RVEEE L+ + K I+ELE+ L
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 475 FEKTKADKLQRE-----------------LEDTRVATVSEK----SRIMELEKDLALRVQ 513
E++ KLQ E LED EK RI E +L +
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT-EEE 1012
Query: 514 EVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETH 573
E ++ +L++ A D+ L +E QE LE TR + + T L + A +
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQE-LEKTRRKLEGDSTDLSDQI-AELQAQ 1070
Query: 574 QKEIKALYTATEKLSKENESLKSKLEHANKENSDV-IALWK-SKLETAIASHQQAMEELK 631
E+K +L+K+ E L++ L +E + +AL K +LE+ I+ Q+ +E +
Sbjct: 1071 IAELKM------QLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 632 VSFSKGLGTET---AEFAELKTQIE----------KMRLDYQHEIENLQNQQDSERAAHA 678
S +K + E LKT++E ++R + E+ L+ + E H
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Query: 679 KEMEALRAKLMKVIKEKENSLE---AIRSKLDKAEDQHLVEMEDTLNKLQ-------EAE 728
+++ +R K + ++E LE +++ L+KA+ E + N+++ ++E
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE 1244
Query: 729 IKVKELEV----LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 784
K K++E LQ K NE +V ++ + ++LD + S+ S+ KL +
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ---VELDNVTGLLSQSDSKSSKLTK 1301
Query: 785 QLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQI 844
A E Q++ + E+ + S++ +L+ E + + +E L E + K LEK++
Sbjct: 1302 DFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIAT 1361
Query: 845 LKEKFAEAS----------EEAVSVQRSMQETVNKLHQKEEQ----FNMLSSDLEKLREN 890
L + A+ E A V+R +Q+ + L Q+ E+ ++ L +L++
Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421
Query: 891 LADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEEL 950
L D+ + + L K ++K + +AE +S + + + E R KE L
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL 1481
Query: 951 QLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQ 1010
L +A E + L++ + + E K ++ + + +LEK Q
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLM--------SSKDDVGKSVHELEKSKRALEQQ 1533
Query: 1011 CQELKARYERATSETKTKHEEILQ---NLQKTLLDTEDKLKGAREENSGLLQELEELRKQ 1067
+E+K + E E + + L+ NLQ E L+G E++ EE +KQ
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS-------EEKKKQ 1586
Query: 1068 ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN 1127
+ AE +E K+++ +A+ + + L+ +D+ +N + +++L
Sbjct: 1587 LVRQVREMEAE-----LEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641
Query: 1128 KSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK 1187
K + + +++++ R E + A + ++L +++ E ++L EEL + + ++
Sbjct: 1642 KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE---RAKRQ 1698
Query: 1188 LEEERSVLNNQL----------LEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAE 1237
++ER L +++ LE K+R I +EE Q + + + L + + +
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758
Query: 1238 LEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKR----QLSSS 1293
++++ ++ + E + A+ + Q LE +L++K++ +E +K + L +
Sbjct: 1759 IDQINTDLNL---ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK 1815
Query: 1294 SGNTDTQADEDERAQES 1310
+ Q D + + +++
Sbjct: 1816 IAQLEEQLDNETKERQA 1832
Score = 157 bits (398), Expect = 5e-38
Identities = 241/1145 (21%), Positives = 489/1145 (42%), Gaps = 180/1145 (15%)
Query: 357 LKEKQQHIEQLLAERD-LERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRT 415
++EKQ E L E + L+ +A+ +++ E L + + L AK +L
Sbjct: 857 VREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRA-RLTAKKQELEE 915
Query: 416 M---VEAADREKVELLNQLEEEKRK----VEDLQFRVEEESITKGDLETQTKLEHARIKE 468
+ +EA E+ E L+ EK+K +++L+ ++EEE + L+ + A++K+
Sbjct: 916 ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK 975
Query: 469 LEQSLLFEKTKADKLQRE---LED------TRVATVSEKSR-IMELEKDLALRVQEVAEL 518
LE+ + + + KL +E LED T + EKS+ + +L+ + ++ E
Sbjct: 976 LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEER 1035
Query: 519 RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDH-------QREITSLKEHFGAREE 571
RR E + QE+ + KLE TD Q +I LK +EE
Sbjct: 1036 LRREEKQR------------QELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 572 THQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELK 631
Q AL E+ +++N +LK K+ + S++ + LE+ AS +A ++ +
Sbjct: 1084 ELQA---ALARVEEEAAQKNMALK-KIRELESQISEL----QEDLESERASRNKAEKQKR 1135
Query: 632 VSFSK--GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM 689
+ L TE + + +++R + E+ L+ + E H +++ +R K
Sbjct: 1136 DLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195
Query: 690 KVIKEKENSLEA---IRSKLDKAEDQHLVEMEDTLNKLQ-------EAEIKVKELEV--- 736
+ ++E LE +++ L+KA+ E + N+++ ++E K K++E
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255
Query: 737 -LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH 795
LQ K NE +V ++ + ++LD + S+ S+ KL + A E Q++
Sbjct: 1256 ELQVKFNEGERVRTELADKVTKLQ---VELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312
Query: 796 LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS-- 853
+ E+ + S++ +L+ E + + +E L E + K LEK++ L + A+
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKK 1372
Query: 854 --------EEAVSVQRSMQETVNKLHQKEEQ------------------FNMLSSDLEKL 887
E A V+R +Q+ + L Q+ E+ + L DL+
Sbjct: 1373 MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ 1432
Query: 888 RENLADMEAKFREKDE--REEQLIKAKEKLENDIAEI---------------MKMSGDNS 930
R++ ++E K ++ D+ EE+ I AK E D AE ++ + +
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492
Query: 931 SQLTKMNDELRLK-------------------------ERDVEELQLKLTK------ANE 959
++L ++N + R + E+ VEE++ +L + A E
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552
Query: 960 NASF-LQKSIEDMTVKAEQSQQEAAKKHEEEKK-------ELERKLSDLEKK--METSHN 1009
+A L+ +++ M + E+ Q ++ EE+KK E+E +L D K+ M +
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAAR 1612
Query: 1010 QCQELKARYERATSETKTKH-EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA 1068
+ E+ + A ++ K+ +E ++ L+K +D ++EL++ R
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD-----------CMRELDDTRASR 1661
Query: 1069 DKAKA-AQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL-DTLKENNLKN---V 1123
++ A A+ E ++ ME + E LA+ E K+ + ++EL D + ++ K +
Sbjct: 1662 EEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAL 1721
Query: 1124 EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVT 1183
EE + + + +++EE + E + + + Q+ + N L E ++
Sbjct: 1722 EEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQI---NTDLNLERSHAQKNEN 1778
Query: 1184 SHQKLEEERSVLNNQLLEM----KKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1239
+ Q+LE + L +L EM K + I + + A L++ + + E+ A +
Sbjct: 1779 ARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNET---KERQAACK 1835
Query: 1240 KLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDT 1299
++R L+ + + K ++K L+ QL+E + + ++ +
Sbjct: 1836 QVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRK 1895
Query: 1300 QADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQ 1359
E E A E+ D +N + L+ K + + + A G GD ++ + D +
Sbjct: 1896 LQRELEDATET-ADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDG-SDEEVDGKADG 1953
Query: 1360 SKKKP 1364
++ KP
Sbjct: 1954 AEAKP 1958
Score = 152 bits (385), Expect = 2e-36
Identities = 218/1017 (21%), Positives = 452/1017 (44%), Gaps = 145/1017 (14%)
Query: 350 TTALQEALKEKQQHIE----QLLAERDLERAEVAKATSHVGEIEQE---LALARDGHDQH 402
T A + L+E+Q +E +L E+ L +A+ T+++ E E++ LA ++ H+
Sbjct: 969 TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028
Query: 403 VLELEAKM---DQLRTMVEAADREK-----------VELLNQLEEEK----RKVEDLQF- 443
+ +LE ++ ++ R +E R+ EL Q+ E K +K E+LQ
Sbjct: 1029 ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAA 1088
Query: 444 --RVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADK--------------LQREL 487
RVEEE+ K + + ++I EL++ L E+ +K L+ EL
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Query: 488 EDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEK 547
EDT +T +++ EL + R QEV L++ LE +E + + +
Sbjct: 1149 EDTLDSTAAQQ----ELR---SKREQEVNILKKTLE---------------EEAKTHEAQ 1186
Query: 548 LEVTRTDHQREITSLKEHFGAREETHQKEIKA-LYTATEKLSKENESLKSKLEHANKENS 606
++ R H + + L E E+T K +KA L A + L E L ++++
Sbjct: 1187 IQEMRQKHSQAVEELAEQL---EQT--KRVKANLEKAKQTLENERGELANEVK------- 1234
Query: 607 DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL 666
V+ K E + ++EL+V F++G T EL ++ K++++ + + L
Sbjct: 1235 -VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT----ELADKVTKLQVELDN-VTGL 1288
Query: 667 QNQQDSERAAHAKEMEALRAKL---MKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
+Q DS+ + K+ AL ++L ++++E+ ++ +KL + ED+ + L +
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEK-NSFREQLEE 1347
Query: 724 LQEAEIKV-KELEVLQAKCNEQTKVIDNFTSQLKATEE---KL-LDLDALRKASSEGKSE 778
+EA+ + K++ L A+ + K +++ L+ EE KL DL+ L + E +
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA 1407
Query: 779 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838
KL + ++++ L ++ + + A ++ E K + L+E +
Sbjct: 1408 YDKLEKTKTRLQQELDDLLVDLDHQRQSACNL-------EKKQKKFDQLLAEEKTISAKY 1460
Query: 839 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 898
+E + + E +A+S+ R+++E + + + E +++E L + D+
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 1520
Query: 899 REKDEREEQLIKAKEKLENDIAEIM-KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA 957
E ++ + L + E+++ + E+ ++ ++L + +K + +LQ + ++
Sbjct: 1521 HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1580
Query: 958 NENASFLQKSIEDMTVKAEQSQQE------AAKKHEEEKKELERKLSDLEKKMETSHNQC 1011
E L + + +M + E +++ A KK E + K+LE + K + + Q
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1640
Query: 1012 QELKARYE---RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL---EELR 1065
++L+A+ + R +T+ EEIL + + E KLK E L +EL E +
Sbjct: 1641 RKLQAQMKDCMRELDDTRASREEILAQAK----ENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 1066 KQADKAK-------AAQTAEDAMQIMEQMTKEKTETLASLE---DTKQTNAKLQNELDTL 1115
+QA + + A + + A+ + E+ E +A LE + +Q N +L N D L
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLE--ARIAQLEEELEEEQGNTELIN--DRL 1752
Query: 1116 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK----- 1170
K+ NL+ ++++N L QK E R+++E + K Q++ + K
Sbjct: 1753 KKANLQ-IDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITA 1811
Query: 1171 LAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK---SISIT 1227
L ++ + +++ + K ER Q+ +K+ + D+E+ + ++
Sbjct: 1812 LEAKIAQLEEQLDNETK---ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKA 1868
Query: 1228 SALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK 1284
S L + +LE+ E + NAS + L ++ + +V +L+ +L+
Sbjct: 1869 STRLKQLKRQLEEAEEEA---QRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 148 bits (374), Expect = 3e-35
Identities = 165/687 (24%), Positives = 323/687 (47%), Gaps = 84/687 (12%)
Query: 710 EDQHLVEMEDTLNKLQE----AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL 765
+++ ++ E+ L K++E AE ++ E+E LQ++ + + QL+A E +
Sbjct: 843 QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQE---QLQAETELCAEA 899
Query: 766 DALRKASSEGKSEMKKLRQQLEAA----EKQIKHLEIEKNAESSKASSITRELQGRELKL 821
+ LR + K E++++ LEA E++ +HL+ EK + +L+ E
Sbjct: 900 EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESAR 959
Query: 822 TNLQ-ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML 880
LQ E ++ +++K+ LE+E IL+++ + ++E ++ + E L ++EE+ L
Sbjct: 960 QKLQLEKVTTEAKLKK-LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL 1018
Query: 881 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 940
+ K + D+E + R ++++ ++L K + KLE D ++ + +Q+ ++ +L
Sbjct: 1019 AKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078
Query: 941 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ----QEAAKKHEEEKKELERK 996
KE EELQ L + E A+ QK++ ++ +SQ QE + + + E++
Sbjct: 1079 AKKE---EELQAALARVEEEAA--QKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 997 LSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDT----EDKLKGARE 1052
DL +++E + ++ A E ++K E+ + L+KTL + E +++ R+
Sbjct: 1134 KRDLGEELEALKTELED-TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQ 1192
Query: 1053 ENSGLLQELEELRKQADKAKAAQTAEDAMQIME----QMTKEKTETLASLEDTKQTNAKL 1108
++S ++EL E +Q + KA E A Q +E ++ E L D++ K+
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKA--NLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKV 1250
Query: 1109 QNELDTL--KENNLKNVE------------ELNKSKELLTVENQKMEEFRKEIETLKQAA 1154
+ +L L K N + V EL+ LL+ + K + K+ L ++
Sbjct: 1251 EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL-ESQ 1309
Query: 1155 AQKSQQLSALQEEN---VKLAEELGRSRDEVTS-HQKLEEERSVLNN----------QLL 1200
Q +Q+L LQEEN + L+ +L + DE S ++LEEE +N Q+
Sbjct: 1310 LQDTQEL--LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367
Query: 1201 EMKKRESKFI---KDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS 1257
+MKK+ + + A+E K LQK + S EK A +KL T L+ E
Sbjct: 1368 DMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE------ 1421
Query: 1258 LHSVVQTLESDK---VKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDF 1314
L ++ L+ + LE K K + QL ++ +S+ +A+ + R +E++
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFD-QLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480
Query: 1315 LNSVI-------VDLQRKNQDLKMKVE 1334
L + +L+R N+ + ++E
Sbjct: 1481 LARALEEAMEQKAELERLNKQFRTEME 1507
Score = 131 bits (329), Expect = 5e-30
Identities = 150/657 (22%), Positives = 281/657 (42%), Gaps = 75/657 (11%)
Query: 734 LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 793
++VLQ C K+ + +L + LL + + + E+ K+R++ AAE ++
Sbjct: 809 MKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRL 868
Query: 794 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 853
+E ++ ++ + +LQ +E + ++ K+ LE+ L+ + E
Sbjct: 869 TEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEE 928
Query: 854 EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER----EEQ-- 907
E +Q ++ + + EEQ S +KL+ EAK ++ +E E+Q
Sbjct: 929 ERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC 988
Query: 908 -LIKAKEKLENDIAE--------------IMKMSGDNSSQLTKMNDELRLKERDVEELQL 952
L K K+ LE+ IAE + K+ + + +T + + LR +E+ +EL+
Sbjct: 989 KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 1048
Query: 953 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELER-------------KLSD 999
K +++ L I ++ + + + + AKK EE + L R K+ +
Sbjct: 1049 TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108
Query: 1000 LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ 1059
LE ++ + +A +A + + EE L+ L+ L DT D +E S Q
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEE-LEALKTELEDTLDSTAAQQELRSKREQ 1167
Query: 1060 ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLA-SLEDTKQTNAKLQNELDTLKEN 1118
E+ L+K + + A+T E +Q M Q + E LA LE TK+ A L+ TL+
Sbjct: 1168 EVNILKKTLE--EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN- 1224
Query: 1119 NLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRS 1178
+ E N+ K LL + E RK++E + Q+L E ++ EL
Sbjct: 1225 --ERGELANEVKVLLQGKGDS-EHKRKKVEA-------QLQELQVKFNEGERVRTELA-- 1272
Query: 1179 RDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAEL 1238
D+VT KL+ E + L + + SK KD ++L+ + T LL E++ +
Sbjct: 1273 -DKVT---KLQVELDNVTGLLSQSDSKSSKLTKDF----SALESQLQDTQELLQEENRQK 1324
Query: 1239 EKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTD 1298
L ++ + E S ++ E K LE ++ L Q+ + K+++ S G +
Sbjct: 1325 LSLSTKLKQVEDEK---NSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381
Query: 1299 TQADEDERAQE-------------SQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALN 1342
T + + Q+ + D L LQ++ DL + ++ ++A N
Sbjct: 1382 TAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 180 bits (456), Expect = 1e-44
Identities = 230/1028 (22%), Positives = 467/1028 (45%), Gaps = 141/1028 (13%)
Query: 291 AKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGT 350
A+ A +R + + LKR L+ ++ V + ++ LTE + I+
Sbjct: 934 AELTAKKRKLEDECSELKRDIDDLELT-LAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 992
Query: 351 TALQEALKEK-QQHIEQLLAERD----LERAEVA---KATSHVGEIEQELALARDGHDQH 402
T ++AL+E QQ ++ L AE D L +A+V + G +EQE + D ++
Sbjct: 993 TKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD-LERA 1051
Query: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLE 462
+LE + + + + +K +L +L+++ ++ L R+E+E L+ + K
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL 1111
Query: 463 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRL 522
ARI+ELE+ L E+T ++++ +L DL+ ++E++E RL
Sbjct: 1112 QARIEELEEELEAERT------------------ARAKVEKLRSDLSRELEEISE---RL 1150
Query: 523 ESNKPAGDVDMSLSLLQ--EISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKAL 580
E A V + ++ + E ++ LE H+ +L++ ++I L
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1210
Query: 581 YTATEKLSKENESLKSKLEHANKENSDVIALWKS------KLETAIASHQQAMEELKVSF 634
+KL KE K +L+ +I + LE + H+ EE + S
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270
Query: 635 S------KGLGTETAEFAE-------LKTQIEKMRLDYQHEIENLQNQQDSE-------- 673
+ L TE E + L +Q+ + +L Y ++E+L+ Q + E
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330
Query: 674 -------------RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 720
R + +E EA +A+L +V+ + + + R+K + Q E+E+
Sbjct: 1331 HALQSARHDCDLLREQYEEETEA-KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA 1389
Query: 721 LNK----LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS---- 772
K LQEAE + +E + AKC+ K +++ E+ ++D++ A+
Sbjct: 1390 KKKLAQRLQEAE---EAVEAVNAKCSSLEKTKHRLQNEI---EDLMVDVERSNAAAAALD 1443
Query: 773 ----------SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLT 822
+E K + ++ + +LE+++K+ + L E + L+ + +
Sbjct: 1444 KKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK 1503
Query: 823 NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS 882
NLQE +S++++ + K + L++ + E + +Q +++E L + E+ +L +
Sbjct: 1504 NLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL--EHEEGKILRA 1561
Query: 883 DLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 942
LE + A++E K EKDE EQ AK N + + + ++ N+ LR+
Sbjct: 1562 QLE-FNQIKAEIERKLAEKDEEMEQ---AK---RNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 943 K---ERDVEELQLKLTKANENASFLQKSIEDM--TVKAEQSQQEAAKKHEEEKKELERKL 997
K E D+ E++++L+ AN A+ QK ++ + +K Q Q + A + ++ KE +
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE---NI 1671
Query: 998 SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQK---------TLLDTEDKLK 1048
+ +E++ + +EL+A E+ K +E+++ ++ +L++ + K+
Sbjct: 1672 AIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMD 1731
Query: 1049 GAREENSGLLQE-LEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK----Q 1103
+ ++E ++E R +KAK A T DA + E++ KE+ +T A LE K Q
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAIT--DAAMMAEELKKEQ-DTSAHLERMKKNMEQ 1788
Query: 1104 TNAKLQNELDTLKENNLK-NVEELNK-SKELLTVENQKMEEFRKEIETLK--QAAAQKSQ 1159
T LQ+ LD ++ LK ++L K + +EN+ E ++ E++K + + ++ +
Sbjct: 1789 TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIK 1848
Query: 1160 QLSALQEEN----VKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADE 1215
+L+ EE+ ++L + + + + +V ++++ EE N L K R+ + D E
Sbjct: 1849 ELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLS-KFRKVQHELDEAE 1907
Query: 1216 EKASLQKS 1223
E+A + +S
Sbjct: 1908 ERADIAES 1915
Score = 159 bits (403), Expect = 1e-38
Identities = 223/1056 (21%), Positives = 459/1056 (43%), Gaps = 137/1056 (12%)
Query: 373 LERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLE 432
L+ AE K + + E L A + + ELE KM L +EK +L Q++
Sbjct: 840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLL-------QEKNDLQLQVQ 892
Query: 433 EEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRV 492
E+ + D + R ++ K LE + K + R+++ E+ + +R+LED
Sbjct: 893 AEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM----NAELTAKKRKLED--- 945
Query: 493 ATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTR 552
E S + DL L + +V E + NK + L + I+ L ++ + +
Sbjct: 946 ----ECSELKRDIDDLELTLAKV-EKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 553 TDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALW 612
HQ+ + L + + ++ L A KL ++ + L+ LE K D +
Sbjct: 1001 EAHQQALDDL--------QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD-LERA 1051
Query: 613 KSKLETAIASHQQAMEEL------------KVSFS-KGLGTETAEFAELKTQIEKMRLDY 659
K KLE + Q+++ +L K F L + L +Q++K +
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL 1111
Query: 660 QHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMED 719
Q IE L+ + ++ER A AK +E LR+ L + LE I +L++A V++E
Sbjct: 1112 QARIEELEEELEAERTARAK-VEKLRSDLSR-------ELEEISERLEEAGGATSVQIE- 1162
Query: 720 TLNKLQEAEIKVKELEVLQAKCNEQTKVI---DNFTSQLKATEEKLLDLDALRKASSEGK 776
+NK +EAE + ++ +A + + E++ +L +++ + K
Sbjct: 1163 -MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1221
Query: 777 SEMK--------KLRQQLEA---AEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ 825
SE K + Q ++A EK + LE + N SKA R + + LQ
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
Query: 826 ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 885
E+S ++ EKE I ++ + ++ + +++ +L ++ + N L+ L+
Sbjct: 1282 TENGELS--RQLDEKEALI-----SQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQ 1334
Query: 886 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK-- 943
R + + ++ E+ E + +L + K +++A+ ++ Q T+ +E + K
Sbjct: 1335 SARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1394
Query: 944 ------ERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK------ 991
E VE + K + + LQ IED+ V E+S AA ++++
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA 1454
Query: 992 ELERKLSDLEKKMETSHNQCQ-------ELKARYERATSETKTKHEEILQNLQKTLLDTE 1044
E ++K + + ++E+S + + +LK YE + +T E +NLQ+ + D
Sbjct: 1455 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE-NKNLQEEISDLT 1513
Query: 1045 DKLKGAREENSGLLQELEELRKQ--ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK 1102
++L + + + ELE++RKQ A+K + E+A +E E+ + L + +
Sbjct: 1514 EQLGSSGK----TIHELEKVRKQLEAEKMELQSALEEAEASLEH---EEGKILRAQLEFN 1566
Query: 1103 QTNAKLQ-------NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIE-TLKQAA 1154
Q A+++ E++ K N+L+ V+ L S + T + +K++E L +
Sbjct: 1567 QIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Query: 1155 AQKS--QQLSALQEENVKLAEELGRSR-----DEVTSHQKLEEERSVL--NNQLLEMKKR 1205
Q S +++A ++ VK + L + D V ++ L+E +++ N LL+ +
Sbjct: 1627 IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE 1686
Query: 1206 ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTL 1265
E + + + E L + EL + V +L +N SL + + +
Sbjct: 1687 ELRAVVEQTERSRKL-------------AEQELIETSERVQLLHSQNT---SLINQKKKM 1730
Query: 1266 ESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRK 1325
++D +L+ +V+ + + + + + + A+E ++ Q++ L + ++++
Sbjct: 1731 DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNMEQT 1789
Query: 1326 NQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1361
+DL+ +++ + AL G L ++ +E +++
Sbjct: 1790 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENE 1825
Score = 152 bits (385), Expect = 2e-36
Identities = 205/1038 (19%), Positives = 450/1038 (43%), Gaps = 118/1038 (11%)
Query: 356 ALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRT 415
++KE+ +++ L + + R E+ + + + + +L L ++ + E + DQL
Sbjct: 851 SMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIK 910
Query: 416 MVEAADREKVELLNQLEEE----------KRKVED----LQFRVEEESITKGDLETQTKL 461
+ + E+ +LE+E KRK+ED L+ +++ +T +E +
Sbjct: 911 NKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHA 970
Query: 462 EHARIKELEQ------SLLFEKTKADKLQRE----------LEDTRVATVSE-KSRIMEL 504
++K L + ++ + TK K +E E+ +V T+++ K ++ +
Sbjct: 971 TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ 1030
Query: 505 EKDLALRVQEVAELRRRLE--SNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSL 562
DL +++ ++R LE K GD+ ++ + ++ + +++L+ E+ +L
Sbjct: 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 563 K---EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETA 619
E A QK++K L E+L +E E+ ++ K SD+ +LE
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL----SRELEEI 1146
Query: 620 IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK 679
++A V E AEF +++ +E+ L QHE A A
Sbjct: 1147 SERLEEAGGATSVQIEMNKKRE-AEFQKMRRDLEEATL--QHE-------------ATAA 1190
Query: 680 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQA 739
+ A + + E+ ++L+ ++ KL+K + + +E++D + +++ +K L+
Sbjct: 1191 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI---IKAKANLEK 1247
Query: 740 KCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE 799
C ++ S+ + T+ + DL + R ++ ++E +L +QL+ E I L
Sbjct: 1248 MCRTLEDQMNEHRSKAEETQRSVNDLTSQR---AKLQTENGELSRQLDEKEALISQLTRG 1304
Query: 800 KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSV 859
K + + + R+L+ E+K N ++ ++ + +L+E++ E +E +
Sbjct: 1305 KLTYTQQLEDLKRQLE-EEVKAKN------ALAHALQSARHDCDLLREQYEEETEAKAEL 1357
Query: 860 QRSMQETVNKLHQKEEQFNM--------LSSDLEKLRENLADMEAKFREKDEREEQLIKA 911
QR + + +++ Q ++ L +KL + L + E + + L K
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417
Query: 912 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 971
K +L+N+I ++M +++ ++ + R ++ + E + K ++ QK +
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1477
Query: 972 TVK------AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSET 1025
+ + A + E + + E K L+ ++SDL +++ +S EL+ ++ +E
Sbjct: 1478 STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE- 1536
Query: 1026 KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIME 1085
K + + L+ + +L E K+ A+ E + + E+E RK A+K + ME
Sbjct: 1537 KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE--RKLAEKDEE----------ME 1584
Query: 1086 QMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRK 1145
Q + + SL+ + + +NE +K+ K +LN+ + L+ N+ E +K
Sbjct: 1585 QAKRNHLRVVDSLQTSLDAETRSRNEALRVKK---KMEGDLNEMEIQLSHANRMAAEAQK 1641
Query: 1146 EIETLKQAAAQKSQQLSALQEENVKLAEELG-RSRDEVTSHQKLEEERSVLNNQLLEMKK 1204
++++L+ QL N L E + R +LEE R+V+ K
Sbjct: 1642 QVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL 1701
Query: 1205 RESKFIKDADEEKASLQKSISITSALLTEK---DAELEKLRNEV--TVLRGENASAKSLH 1259
E + I+ ++ +Q S ++L+ +K DA+L +L+ EV V NA K+
Sbjct: 1702 AEQELIETSER----VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKK 1757
Query: 1260 SVVQTL---------ESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQES 1310
++ + LE KN+E +K+ + +L + + + E+
Sbjct: 1758 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEA 1817
Query: 1311 QIDFLNSVIVDLQRKNQD 1328
++ L + + Q++N +
Sbjct: 1818 RVRELENELEAEQKRNAE 1835
Score = 138 bits (348), Expect = 3e-32
Identities = 154/723 (21%), Positives = 320/723 (44%), Gaps = 83/723 (11%)
Query: 702 IRSKLDKAE-DQHLVEMEDTLNKLQEA----EIKVKELEVLQAKCNEQTKVIDNFTSQLK 756
I+ L AE ++ + M++ +L+EA E + KELE ++ ++ Q++
Sbjct: 836 IKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEK---NDLQLQVQ 892
Query: 757 ATEEKLLDL----DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 812
A ++ L D D L K + ++++K++ ++LE E+ L +K + S + R
Sbjct: 893 AEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKR 952
Query: 813 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 872
++ EL L +++ + L +E+ L E A+ ++E ++Q + Q+ ++ L
Sbjct: 953 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQA 1012
Query: 873 KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQ 932
+E++ N L+ KL + + D+E ++ + L +AK KLE D+ + D +
Sbjct: 1013 EEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND 1072
Query: 933 LTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE------AAKKH 986
++++ L+ K+ ++ L ++ S LQK ++++ + E+ ++E A K
Sbjct: 1073 KQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKV 1132
Query: 987 EEEKKELERKLSDLEKKMETS---------------------HNQCQELKARYERATSET 1025
E+ + +L R+L ++ +++E + +E ++E +
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 1026 KTKHE-------EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK-QADKAKAAQTA 1077
+ KH E + NLQ+ E + + E + +E++ K +A+ K +T
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252
Query: 1078 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ---NELDTLKENNLKNVEELNKSKELLT 1134
ED Q+ E +K + ET S+ D AKLQ EL + + +L + K T
Sbjct: 1253 ED--QMNEHRSKAE-ETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT 1309
Query: 1135 VENQKMEEFRKEIE---TLKQAAAQKSQ-----------QLSALQEENVKLAEELGRSRD 1180
Q++E+ ++++E K A A Q Q E +L L ++
Sbjct: 1310 ---QQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 1181 EVTS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1239
EV K E + +L E KK+ ++ +++A+E ++ S E+E
Sbjct: 1367 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1426
Query: 1240 KLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDT 1299
L +V NA+A +L + DK+ E K K E Q + Q + S T
Sbjct: 1427 DLMVDV---ERSNAAAAALDKKQRNF--DKILAEWKQKYEESQSELESSQKEARS--LST 1479
Query: 1300 QADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQ 1359
+ + + A E ++ L + +R+N++L+ ++ ++E L +G ++ + ++ +
Sbjct: 1480 ELFKLKNAYEESLEHLET----FKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLE 1534
Query: 1360 SKK 1362
++K
Sbjct: 1535 AEK 1537
Score = 123 bits (308), Expect = 1e-27
Identities = 179/836 (21%), Positives = 361/836 (43%), Gaps = 136/836 (16%)
Query: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397
E S + G T++Q + +K++ Q + RDLE A + + E A R
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKM-RRDLEEATL--------QHEATAAALRK 1194
Query: 398 GHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLET 457
H V EL ++D L+ + + ++EK E K +++D+ +E+ K +LE
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEF-------KLELDDVTSNMEQIIKAKANLEK 1247
Query: 458 QTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAE 517
+ LE + ++KA++ QR + D S+++++ +L+ ++ E
Sbjct: 1248 MCRT-------LEDQMNEHRSKAEETQRSVNDL----TSQRAKLQTENGELSRQLDEKEA 1296
Query: 518 LRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEI 577
L +L K L+ Q++ L+ +LE E K ++ + +
Sbjct: 1297 LISQLTRGK--------LTYTQQLEDLKRQLE--------EEVKAKNALAHALQSARHDC 1340
Query: 578 KALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKG 637
L E+ ++ L+ L AN E +A W++K ET + +EE K ++
Sbjct: 1341 DLLREQYEEETEAKAELQRVLSKANSE----VAQWRTKYETDAIQRTEELEEAKKKLAQR 1396
Query: 638 L--GTETAEFAELK-TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 694
L E E K + +EK + Q+EIE+L + AA A ++ + K++ E
Sbjct: 1397 LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA-AAALDKKQRNFDKILAE 1455
Query: 695 KENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA-EIKVKELEVLQAKCNEQTKVIDNFTS 753
+ E +S+L+ ++ + + L KL+ A E ++ LE + + + I + T
Sbjct: 1456 WKQKYEESQSELESSQKEAR-SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE 1514
Query: 754 QLKATEEKLLDLDALRKASSEGKSEM----------------KKLRQQLE----AAEKQI 793
QL ++ + + +L+ +RK K E+ K LR QLE AE +
Sbjct: 1515 QLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER 1574
Query: 794 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKF---- 849
K E ++ E +K + + R + + L + +E +VK+ +E +L ++ +
Sbjct: 1575 KLAEKDEEMEQAKRNHL-RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Query: 850 ---AEASEEAVSVQRSMQETVNKLHQK--------------EEQFNMLSSDLEKLRENLA 892
AEA ++ S+Q +++T +L E + N+L ++LE+LR A
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR---A 1690
Query: 893 DMEAKFREKDEREEQLIKAKEKLE-------NDIAEIMKMSGDNSSQLTKMNDELRLKER 945
+E R + E++LI+ E+++ + I + KM D S T++ + ++
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 946 DVEELQLKLTKANENASFLQK-----------------SIEDMTVKAEQSQQEAAK---- 984
E+ + +T A A L+K +I+D+ + ++++Q A K
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 985 ---KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ------N 1035
K E +ELE +L +K+ S ++ + R + T +T+ + +L+
Sbjct: 1811 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDK 1870
Query: 1036 LQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA-KAAQTAEDAMQIMEQMTKE 1090
LQ + + + + A E+ + L + +++ + D+A + A AE + + +++
Sbjct: 1871 LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRD 1926
Score = 100 bits (249), Expect = 1e-20
Identities = 120/584 (20%), Positives = 254/584 (43%), Gaps = 66/584 (11%)
Query: 347 ISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLEL 406
I T L+EA K+ Q +++ AE +E AK +S L + + +L
Sbjct: 1380 IQRTEELEEAKKKLAQRLQE--AEEAVEAVN-AKCSS--------LEKTKHRLQNEIEDL 1428
Query: 407 EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQT-KLEHAR 465
+++ A D+++ L E K+K E+ Q +E L T+ KL++A
Sbjct: 1429 MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAY 1488
Query: 466 IKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEK------------------- 506
+ LE F++ + LQ E+ D S I ELEK
Sbjct: 1489 EESLEHLETFKRENKN-LQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA 1547
Query: 507 DLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF 566
+ +L +E LR +LE N+ +++ ++++ E++E + +H R + SL+
Sbjct: 1548 EASLEHEEGKILRAQLEFNQIKAEIE------RKLAEKDEEMEQAKRNHLRVVDSLQTSL 1601
Query: 567 GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQA 626
A + + ++ +K+ + ++ +L HAN+ ++ + + S Q
Sbjct: 1602 DAETRSRNEALRV----KKKMEGDLNEMEIQLSHANRMAAEA--------QKQVKSLQSL 1649
Query: 627 MEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQ-QDSERAAHAKEMEALR 685
+++ ++ + + E +E+ Q E+E L+ + +ER+ E E +
Sbjct: 1650 LKDTQIQLDDAVRAND-DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE 1708
Query: 686 -AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQ 744
++ ++++ + SL + K+D Q E+E+ + + + AE K K+ A E+
Sbjct: 1709 TSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE 1768
Query: 745 TKVIDNFTSQL----KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK 800
K + ++ L K E+ + DL + + +K ++QL+ E +++ LE E
Sbjct: 1769 LKKEQDTSAHLERMKKNMEQTIKDLQ--HRLDEAEQIALKGGKKQLQKLEARVRELENEL 1826
Query: 801 NAESSKASSITRELQGRELKLTNL-------QENLSEVSQVKETLEKELQILKEKFAEAS 853
AE + + + ++ E ++ L ++NL + + + L+ +++ K + EA
Sbjct: 1827 EAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAE 1886
Query: 854 EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAK 897
E+A + ++ ++L + EE+ ++ S + KLR D+ K
Sbjct: 1887 EQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930
Score = 55.5 bits (132), Expect = 4e-07
Identities = 75/318 (23%), Positives = 138/318 (43%), Gaps = 48/318 (15%)
Query: 1060 ELEELRKQADKAKAAQT-------AEDAMQIMEQMTKEKTETLAS-LEDTKQTNAKLQNE 1111
+++ L K A++ K + ++A++ E KE E + S L++ ++Q E
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 1112 LDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1171
D L + + ++L K+K L K++E + +E ++ A+ + + L++E
Sbjct: 895 QDNLADAE-ERCDQLIKNKIQL---EAKVKEMNERLEDEEEMNAELTAKKRKLEDE---- 946
Query: 1172 AEELGRSRDEV-TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1230
EL R D++ + K+E+E+ N+ +K+ EE A L + I + L
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENK-----------VKNLTEEMAGLDE---IIAKL 992
Query: 1231 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1290
EK A E + + L+ E V TL KVKLE +V +LE L++ K+
Sbjct: 993 TKEKKALQEAHQQALDDLQAE-------EDKVNTLTKAKVKLEQQVDDLEGSLEQEKK-- 1043
Query: 1291 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDL--KMKVEMMSEAALNGNGDDL 1348
+ +R E + I+DL+ Q L ++K + ALN +D
Sbjct: 1044 ------VRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDE 1097
Query: 1349 NNYDSDDQEKQSKKKPRL 1366
S Q+K + + R+
Sbjct: 1098 QALGSQLQKKLKELQARI 1115
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 177 bits (450), Expect = 5e-44
Identities = 250/1091 (22%), Positives = 486/1091 (44%), Gaps = 135/1091 (12%)
Query: 323 ASSVSSRPSRTGLLTETSSRYARKISGTTA---LQEALKEKQQHIEQLL-AERDLERAEV 378
ASS + P + + T SR + A ++ +E ++ EQLL +++LE+ E+
Sbjct: 227 ASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEI 286
Query: 379 AKATSHVGEIEQE-LALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRK 437
+ ++QE + L D + E +D LR D+ L +++ K +
Sbjct: 287 -----ELKRLQQENMNLLSDARSARMYRDE--LDALREKAVRVDK----LESEVSRYKER 335
Query: 438 VEDLQF---RVEE-ESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVA 493
+ D++F RVEE + + LET+T LE +LE + + ++DKL ELE +
Sbjct: 336 LHDIEFYKARVEELKEDNQVLLETKTMLED----QLEGT----RARSDKLH-ELEKENLQ 386
Query: 494 TVSEKSRIMELEKDL-ALRVQEVAELRRRLESNKPAGDVDMSLSL---LQEISSLQEKLE 549
+ K ME+E+D+ +++E+ E LE + +D SL L L++IS E E
Sbjct: 387 -LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQS-MDESLHLGWELEQISRTSELSE 444
Query: 550 VTRTDHQREITSLKEH----FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKEN 605
+ E+ L ++ K ++ L T + + + N S K+E N+
Sbjct: 445 APQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV-EGNASKILKMEKENQRL 503
Query: 606 SDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIEN 665
S + + LE I +Q+++ + + SK L E A+ L+ IE +R + + +I+
Sbjct: 504 SKKVEI----LENEIVQEKQSLQNCQ-NLSKDLMKEKAQ---LEKTIETLRENSERQIKI 555
Query: 666 LQNQQD--SERAAHAKEMEALRAKLMKVIKEKEN-----SLEAIRSKLDKAEDQHLVEME 718
L+ + + ++ + ++ + A+ EKEN S++ SKL K E + +++
Sbjct: 556 LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR-QIK 614
Query: 719 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
L +E + +ELE ++ +++ + LK T EK+ +AL + +SE + E
Sbjct: 615 KELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI---EALEQENSELERE 671
Query: 779 MKKLRQ----------QLEAAEKQI-----KHLEIEKNAESSKASSITRELQGRELKLTN 823
+KL++ QLE+ EK+ ++LE+ +N ES K +S +K+
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCAS---------MKMAQ 722
Query: 824 LQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ------RSMQETVNKLHQKEEQF 877
LQ E+ KE L+K L++LK F + VS Q + +Q+T+ ++K +Q
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 878 NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN 937
DLE + L + + +R EQL K + LE + +++ K + QL K N
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK----DKKQLEKEN 838
Query: 938 DELR----LKERDVEELQLKLTKANENASFLQKSI---EDMTVKAEQSQQEAAK------ 984
LR +K+ +EE +K+ + L K I ++ V+ ++ ++E +
Sbjct: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT 898
Query: 985 ------------------KHEEEKKELERKLSDLEK----KMETSHNQCQELKARYERAT 1022
K ++ +LE+ +LEK K H++ +RY+
Sbjct: 899 IDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLE 958
Query: 1023 SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQ 1082
S+ ++ ++ L+ ++ + E +L+ + N L QEL+ ++K + K Q E +Q
Sbjct: 959 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1018
Query: 1083 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEE 1142
++ E + ++T + K+++ L ++ NN E K L +
Sbjct: 1019 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN 1078
Query: 1143 FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEM 1202
+ +I L++ +Q + LQ +N KL E + TS L + + L Q +
Sbjct: 1079 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTS---LMNQNAQLLIQQSSL 1135
Query: 1203 KKRESKFIKDADEEKA---SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLH 1259
+ IK+ ++ K+ SL K L + +E E L ++ L+ + + + H
Sbjct: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH 1195
Query: 1260 SVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI 1319
++ + +K + ++++LE LK + ++ + N +T A E ++ + D LN
Sbjct: 1196 RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC-GENDRLNHTY 1254
Query: 1320 VDLQRKNQDLK 1330
L ++ + L+
Sbjct: 1255 SQLLKETEVLQ 1265
Score = 86.7 bits (213), Expect = 1e-16
Identities = 203/1019 (19%), Positives = 408/1019 (40%), Gaps = 149/1019 (14%)
Query: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
LQ+ L+ + I+QL E +L+ E+ T + + +EL ++ +Q LE E K +
Sbjct: 768 LQKTLENSNKKIQQL--ESELQDLEMENQT--LQKNLEELKISSKRLEQ--LEKENKSLE 821
Query: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKL----------E 462
T D++++E N+ ++ +++D +EE ++ G+LE + K
Sbjct: 822 QETSQLEKDKKQLEKENKRLRQQAEIKDTT--LEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 463 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAEL---- 518
R+KELE+ +A + L R VSEK + ++ DL E+ ++
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 519 RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQ--KE 576
R L + D L + S+L++ LE+ L+E ++ Q K
Sbjct: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
Query: 577 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 636
+K Y A ++ E ++S + ++N W+ + + + + L + +
Sbjct: 1000 VKKNYEALKQRQDEERMVQSSPPISGEDNK-----WERESQETTRELLKVKDRL-IEVER 1053
Query: 637 GLGTETAEFAELKTQIEKMR----------LDYQHEIENLQNQQDSERAAHAK-EMEALR 685
T AE LKTQ++++ L Q + +LQ Q + + +AK ++E
Sbjct: 1054 NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1113
Query: 686 AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE-LEVLQAKCNEQ 744
+N+ I+ + E++ +++ + L L ++ IK E LE+L + +
Sbjct: 1114 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1173
Query: 745 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK---- 800
+ + + LK+ + +L+ + + +++ K + QLE EK +K +E EK
Sbjct: 1174 YESLISKHGTLKSAHK---NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK-VEQEKMLLE 1229
Query: 801 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 860
N ++ ++L G +L + L + ++V +T K L+ L
Sbjct: 1230 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL--------------- 1274
Query: 861 RSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA 920
+ +S LE+ R +EA+F + E+ +QL KL N
Sbjct: 1275 ------------------LNNSKLEQTR-----LEAEFSKLKEQYQQLDITSTKLNNQCE 1311
Query: 921 EIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 980
+ ++ G+ + + D+++ T +N + L++++E + + +Q
Sbjct: 1312 LLSQLKGNLEEENRHLLDQIQ-------------TLMLQNRTLLEQNMESKDLFHVEQRQ 1358
Query: 981 EAAKKHE--EEKKELERKLSDLEKKMETS----HNQCQELKARYERATSETKTKHEEILQ 1034
K +E +K++LE K+ D K + S LK R K+K ++I +
Sbjct: 1359 YIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMR-----KLIKSK-KDINR 1412
Query: 1035 NLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTET 1094
QK+L L R ++S +L Q + + + ED + + + +
Sbjct: 1413 ERQKSL-----TLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDL 1467
Query: 1095 LASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAA 1154
+ S+ Q + NL+ ++++ K + T+ +A
Sbjct: 1468 VQSMVLAGQWTGSTE---------NLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSA 1518
Query: 1155 AQKSQQLSALQEENVKLAEEL---GRSRDEVTSHQ-------KLEEERSVLNNQLLEMKK 1204
+S+QL + ++ E++ G S D T + L+ R+ +N
Sbjct: 1519 GFRSKQL--VNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASL 1576
Query: 1205 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSL-HSVVQ 1263
E K A ++ Q S +LL + +A + + L+ + S+ L H + +
Sbjct: 1577 HEVK--AGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISE 1634
Query: 1264 TLESDKVKLELKVKNLEL----QLKENKRQLSS---SSGNTDTQADEDERAQESQIDFL 1315
TLES K++ E+ Q E +L+S S + + DE ++ DFL
Sbjct: 1635 TLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFL 1693
Score = 62.8 bits (151), Expect = 2e-09
Identities = 120/518 (23%), Positives = 205/518 (39%), Gaps = 104/518 (20%)
Query: 825 QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL 884
QE L ++ + +L L I K F+E E V + QK+E+F +
Sbjct: 91 QETLQQL--IMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEF------I 142
Query: 885 EKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK- 943
E+++ D + K +E + + E+ MS ++ L K N L LK
Sbjct: 143 ERIQG--LDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLK-NMALHLKR 199
Query: 944 ---ERDVE-ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 999
ERD E ++L++ + FL + + A+ K E ++ L +L+D
Sbjct: 200 LIDERDEHSETIIELSEERDGLHFLPHA----SSSAQSPCGSPGMKRTESRQHLSVELAD 255
Query: 1000 LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ 1059
KA+ R E + K E++L Q+ L E +LK ++EN LL
Sbjct: 256 A--------------KAKIRRLRQELEEKTEQLLDCKQE-LEQMEIELKRLQQENMNLLS 300
Query: 1060 ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENN 1119
+ R D+ A + E A+++ KL++E+ KE
Sbjct: 301 DARSARMYRDELDALR--EKAVRV----------------------DKLESEVSRYKER- 335
Query: 1120 LKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSR 1179
L ++E E L +NQ + E + +E + +S +L L++EN++L +L
Sbjct: 336 LHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME 395
Query: 1180 DEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1239
E +K EE + N LEM +++S D + IS TS L
Sbjct: 396 MERDMDRKKIEEL-MEENMTLEMAQKQSM---DESLHLGWELEQISRTSEL--------- 442
Query: 1240 KLRNEVTVLRGENASAKSL-HSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTD 1298
A KSL H V + S +KLE++ ++L ++E + + S GN
Sbjct: 443 -----------SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA- 490
Query: 1299 TQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1336
S I+ ++++NQ L KVE++
Sbjct: 491 ------------------SKILKMEKENQRLSKKVEIL 510
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 177 bits (450), Expect = 5e-44
Identities = 248/1093 (22%), Positives = 481/1093 (44%), Gaps = 150/1093 (13%)
Query: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ---ELALARDGHDQHVLELEAKM 410
+ LKE +Q QL E++L + ++ T E E+ LA + ++ + E+EA++
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 931
Query: 411 DQLRTMVEAADREKVELLNQLEEEKRKVE----DLQFRVEEESITKGDLETQTKLEHARI 466
+ E DR + QL+ E++K+ DL+ ++EEE + L+ + A+I
Sbjct: 932 E------EEEDRGQ-----QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 980
Query: 467 KELEQSLLFEKTKADKLQRE---LED------TRVATVSEKSR------------IMELE 505
K+LE +L + +KL +E LE+ T +A EK++ I ELE
Sbjct: 981 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Query: 506 KDLALRV---QEVAELRRRLESNKPAGDVDMSLSLLQ-EISSLQEKLEVTRTDHQREITS 561
L QE+ +L+R+LE + A D ++ LQ +I+ L+ +L + Q +
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGD--ASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 562 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV---IALWKSKLE- 617
L + A++ K+I+ L L ++ +S ++ A K+ D+ + K++LE
Sbjct: 1099 LDDEI-AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 618 ----TAIASHQQAMEELKVS-FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDS 672
TA +A E +V+ K L ET + Q+++MR + +E L Q +
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 673 ERAAHA----------KEMEALRAKLMKV------IKEKENSLEA----IRSKLDKAEDQ 712
+ A A KE L +L + ++ K+ LEA ++SK E
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 713 HLVEMEDTLNKLQ-EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE--------KLL 763
E+ D ++KLQ E E L + K + K + + +SQL+ T+E KL
Sbjct: 1275 R-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Query: 764 DLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHLEIEKNAESSKASSITRELQGRELK 820
LR+ E S +L +++EA E+ I L I+ + K ++ E
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 821 LTNLQ---ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877
Q ENL++ + K +L+ K + + ++ V + ++ V+ L +K+ +F
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 878 NMLSSDLEKLRENLAD----MEAKFREKDERE-------EQLIKAKEKLEN-------DI 919
+ L ++ + + AD EA+ REK+ + E+ ++AKE+LE ++
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513
Query: 920 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK------ANENASF-LQKSIEDMT 972
+++ D + ++ R E +EE++ +L + A E+A L+ +++ +
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1573
Query: 973 VKAEQSQQEAAKKHEEEKKELERKL-------SDLEKKMETSHNQCQELKARYE----RA 1021
+ E+ Q +++EE++++L+R+L D K+ + ++L+ + +A
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1633
Query: 1022 TSETKTKHEEI--LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAED 1079
S K + E I L+ LQ + D + +L+ AR + +E K+A +A D
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-----D 1688
Query: 1080 AMQIMEQM-TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQ 1138
MQ+ E + E+ A LE +L EL + +E + + + +
Sbjct: 1689 LMQLQEDLAAAERARKQADLE-----KEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743
Query: 1139 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1198
++EE + +E + + +QQ L E LA E ++ ++ Q+LE + L ++
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNE---LATERSTAQKNESARQQLERQNKELRSK 1800
Query: 1199 LLEMKKR-ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS 1257
L EM+ +SKF +A + + EK A + L+ + L+ +
Sbjct: 1801 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1860
Query: 1258 LHSVVQTLESDKVKLELKVKNLELQL---KENKRQLSSSSGNTDTQADEDERAQESQIDF 1314
+ + + K +VK L+ QL +E ++++++ + DE + E+
Sbjct: 1861 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920
Query: 1315 LNSVIVDLQRKNQ 1327
+N++ L+R N+
Sbjct: 1921 VNALKSKLRRGNE 1933
Score = 172 bits (435), Expect = 3e-42
Identities = 222/958 (23%), Positives = 424/958 (44%), Gaps = 104/958 (10%)
Query: 436 RKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELE-DTRVAT 494
R+ E++Q + +E TK E Q K E+ +KELEQ + + LQ +L+ +T +
Sbjct: 849 RQEEEMQAKEDELQKTK---ERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 495 VSEKSRIMELEKDLALRVQEVA----ELRRRLESNKPAGDVDMS--LSLLQEISSLQEKL 548
+E+ R+ LA + QE+ E+ RLE + G + + Q++ L+E+L
Sbjct: 905 EAEEMRVR-----LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 549 EVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH--ANKENS 606
E Q+ + K A+ + + EI + KLSKE + L+ ++ N
Sbjct: 960 EEEEAARQK-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 607 DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL 666
+ A +KL+ H+ + EL+V K E +LK ++E D+ +I +L
Sbjct: 1019 EEKAKNLTKLKN---KHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 667 QNQQDSERAAHAKEMEALRAKLMKV---IKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
Q Q + AK+ E L+A L ++ I +K N+L+ IR + H+ ++++ L+
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL-----EGHISDLQEDLDS 1129
Query: 724 LQEAEIKVKEL-----EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
+ A K ++ E L+A E +D+ +Q + ++ ++ L+KA
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA------- 1182
Query: 779 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838
L ++ + E Q++ + +K+A++ +T +L+ + NL +N + + L
Sbjct: 1183 ---LDEETRSHEAQVQEMR-QKHAQA--VEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236
Query: 839 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 898
EL++L + E + ++ +QE +K E L+ + KL+ + +
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296
Query: 899 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKAN 958
E + + +L K L + + + ++ + + Q ++ +LR E + LQ +L +
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 959 ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARY 1018
E L++ I + ++ S+++ + + LE +K++E Q +E A Y
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKK-LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 1019 ERATSETKTKHEEILQNLQKTLLDTEDKL-----KGAREENSGLLQELEELRKQADKAKA 1073
++ +TK + ++ L +L LD + +L K R+ + L +E K AD+
Sbjct: 1416 DK-LEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 1074 AQT-AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL---KENNLKNVEELNKS 1129
A+ A + + + E L + E+ ++TN L+ E++ L K++ KNV EL KS
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 1130 KELLTVENQKMEEFRKEIETLKQAA---------------AQKSQQLSALQEENVKLAEE 1174
K L + ++M+ +E+E QA Q + L A E+N + +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 1175 LGRSRDEVTSHQKLEEER----------SVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1224
L R E + +LE+ER L L +++ + IK +E L+K
Sbjct: 1594 LQRQLHEYET--ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK-- 1649
Query: 1225 SITSALLTEKDAELEKL---RNEVTVLRGEN-ASAKSLHSVVQTLESDKVKLELKVKNLE 1280
A + + ELE R+E+ EN AKSL + + L+ D E K +
Sbjct: 1650 --LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 1281 LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
L+ +E +L+SS + DE R L + I L+ + ++ + +E MS+
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRR--------LEARIAQLEEELEEEQGNMEAMSD 1757
Score = 149 bits (376), Expect = 2e-35
Identities = 145/574 (25%), Positives = 259/574 (45%), Gaps = 54/574 (9%)
Query: 792 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 851
Q+ E E A+ + Q E +L L++ S++++ K L+++LQ E +AE
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 852 ASEEAVSVQRSMQETVNKLH-------QKEEQFNMLSSDLEKLRENLADMEAKFREKDER 904
A E V + QE LH ++E++ L ++ +K+ + + D+E + E++
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 905 EEQL----IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
++L + A+ K++ EI+ M N+ K++ E +L E + +L L + E
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNN----KLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
A L K +++ + KK E+ ++ELE+ LE H Q +L+A+
Sbjct: 1022 AKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 1021 ATSETKTKHEEI---LQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKAAQT 1076
+ K EE+ L L + + LK RE + E+L ++A + KA +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1077 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1136
D + +E + E +TL S ++ AK + E+ LK K ++E +S E E
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KALDEETRSHEAQVQE 1196
Query: 1137 -----NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE---LGRSRDEVTSHQKL 1188
Q +EE +++E K+A A + L++EN LA E LG+++ EV H+K
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKK 1255
Query: 1189 EEERSVLNNQLLEMKKRESKFIK-DADEEKASLQKSISITSALLTEKDAELEKLRNEVTV 1247
+ E V Q L+ K + + + + +++ LQ + + +L E + + KL +V
Sbjct: 1256 KLEAQV---QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV-- 1310
Query: 1248 LRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERA 1307
AS S Q L ++ + +L V QL+E + L Q DE+ A
Sbjct: 1311 -----ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEA 1358
Query: 1308 Q---ESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
+ E I LN + D ++K QD VE + E
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Score = 141 bits (355), Expect = 5e-33
Identities = 174/836 (20%), Positives = 352/836 (42%), Gaps = 119/836 (14%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
S + E ++A+ + T E K + ++++ + E A++A +G+ +Q
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESI 450
E+ + + V EL++K E A E + +++L+ E V + E ++I
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSD----GERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 451 TKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLAL 510
+ +EL Q +K R+LE+ R + + ME +++L
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE- 1363
Query: 511 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 570
+ ++ L +L +K LQ+ +S E LE + Q+EI +L
Sbjct: 1364 --RHISTLNIQLSDSK---------KKLQDFASTVEALEEGKKRFQKEIENL-------- 1404
Query: 571 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 630
T Q E KA A +KL K L QQ +++L
Sbjct: 1405 -TQQYEEKA--AAYDKLEKTKNRL-----------------------------QQELDDL 1432
Query: 631 KVSFSKGLGTETAEFAELKTQIEKMRLDYQH---EIENLQNQQDSERAAHAKEMEALRAK 687
V +L + +EK + + E +N+ ++ ER E K
Sbjct: 1433 VVDLDNQ--------RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484
Query: 688 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELE----VLQAKCNE 743
+ + + E +LEA + +L++ EMED ++ + V ELE L+ + E
Sbjct: 1485 ALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 744 QTKVIDNFTSQLKATEEKLLDLDA------------LRKASSEGKSEMKKLRQQLEAAEK 791
++ +L+ATE+ L L+ L+ + + + ++L++QL E
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 792 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 851
+++ ++ + + A++ ++L+G L +L+ + +E K+L+ L+ + +
Sbjct: 1604 ELE----DERKQRALAAAAKKKLEG---DLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 852 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 911
E + S E + E++ L +DL +L+E+LA E ++ D
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD-------LE 1709
Query: 912 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 971
KE+L ++A +SG N+ Q DE R E + +L+ +L + N + +
Sbjct: 1710 KEELAEELAS--SLSGRNALQ-----DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 972 TVKAEQ------SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSET 1025
T +AEQ +++ A+K+E +++LER+ +L K+ H +K++++ +
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL---HEMEGAVKSKFKSTIAAL 1819
Query: 1026 KTKHEEILQNLQKTLLDTEDKLKGAREENSGL---LQELEELRKQADKAKAAQTAEDAMQ 1082
+ K ++ + +++ + + K ++++ L L ++E+ RK A++ K + AE
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK--EQAEKGNA 1877
Query: 1083 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQ 1138
++Q+ ++ E + KLQ ELD E+N E+N K L N+
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 112 bits (281), Expect = 2e-24
Identities = 147/684 (21%), Positives = 281/684 (41%), Gaps = 92/684 (13%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
S TG+L E + + +L L++ Q+ +++ E + ++ + ++E+
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-------ETRQKLNVSTKLRQLEE 1343
Query: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN-QLEEEKRKVEDLQFRVEEES 449
E +D D+ E+EAK + R + LN QL + K+K++D VE +
Sbjct: 1344 ERNSLQDQLDE---EMEAKQNLER---------HISTLNIQLSDSKKKLQDFASTVE--A 1389
Query: 450 ITKGDLETQTKLEHARIKELEQSLLFEKTKADK--LQRELEDTRVATVSEKSRIMELEKD 507
+ +G Q ++E+ + E++ ++K + K LQ+EL+D V +++ + LEK
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 508 LALRVQEVAELRRRLESNKPAGDVDMS-----------LSLLQEIS-SLQEKLEVTRTD- 554
Q +AE + S+K A + D + LSL + + +L+ K E+ RT+
Sbjct: 1450 QRKFDQLLAEEKNI--SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 555 ----HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 610
++ S K+ G +K +AL T E++ + E L+ +L+
Sbjct: 1508 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA------ 1561
Query: 611 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 670
K +LE M+ LK F + L + E + Q+++ +Y+ E+E+ + Q+
Sbjct: 1562 --KLRLEVN-------MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 671 DSERAAHAK---EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT------- 720
AA K +++ L + IK +E +++ +R KL E+ED
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKDFQRELEDARASRDEI 1671
Query: 721 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD---------------- 764
+E E K K LE + E + Q +E+L +
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 765 ------LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
+ L + E + M+ + ++ A +Q + L E E S A Q E
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 819 LKLTNLQENLSEVS-QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877
+ L+ L E+ VK + + L+ K A+ E+ R Q L QK+++
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 878 NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN 937
+ +E R+ + + + + R +QL + E+ E + I +L +
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911
Query: 938 DELRLKERDVEELQLKLTKANENA 961
+ R+V L+ KL + NE +
Sbjct: 1912 ESNEAMGREVNALKSKLRRGNETS 1935
Score = 55.8 bits (133), Expect = 3e-07
Identities = 55/239 (23%), Positives = 99/239 (41%), Gaps = 48/239 (20%)
Query: 299 VMATTSASLKRSPS--ASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEA 356
+ AT + K++ S A + +A++ +R E + A +SG ALQ+
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1730
Query: 357 LKEKQQHIEQLLAERDLERA-------EVAKATSHVGEIEQELALARDGHDQH------- 402
+ + I QL E + E+ V KAT ++ ELA R ++
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 403 -------------------------VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRK 437
+ LEAK+ QL VE REK L+++ +K
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 438 VEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKAD-------KLQRELED 489
++++ +VE+E + Q + +AR+K+L++ L + ++ KLQREL++
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 177 bits (450), Expect = 5e-44
Identities = 248/1093 (22%), Positives = 481/1093 (44%), Gaps = 150/1093 (13%)
Query: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ---ELALARDGHDQHVLELEAKM 410
+ LKE +Q QL E++L + ++ T E E+ LA + ++ + E+EA++
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 938
Query: 411 DQLRTMVEAADREKVELLNQLEEEKRKVE----DLQFRVEEESITKGDLETQTKLEHARI 466
+ E DR + QL+ E++K+ DL+ ++EEE + L+ + A+I
Sbjct: 939 E------EEEDRGQ-----QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 987
Query: 467 KELEQSLLFEKTKADKLQRE---LED------TRVATVSEKSR------------IMELE 505
K+LE +L + +KL +E LE+ T +A EK++ I ELE
Sbjct: 988 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Query: 506 KDLALRV---QEVAELRRRLESNKPAGDVDMSLSLLQ-EISSLQEKLEVTRTDHQREITS 561
L QE+ +L+R+LE + A D ++ LQ +I+ L+ +L + Q +
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGD--ASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 562 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV---IALWKSKLE- 617
L + A++ K+I+ L L ++ +S ++ A K+ D+ + K++LE
Sbjct: 1106 LDDEI-AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 618 ----TAIASHQQAMEELKVS-FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDS 672
TA +A E +V+ K L ET + Q+++MR + +E L Q +
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 673 ERAAHA----------KEMEALRAKLMKV------IKEKENSLEA----IRSKLDKAEDQ 712
+ A A KE L +L + ++ K+ LEA ++SK E
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 713 HLVEMEDTLNKLQ-EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE--------KLL 763
E+ D ++KLQ E E L + K + K + + +SQL+ T+E KL
Sbjct: 1282 R-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Query: 764 DLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHLEIEKNAESSKASSITRELQGRELK 820
LR+ E S +L +++EA E+ I L I+ + K ++ E
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 821 LTNLQ---ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877
Q ENL++ + K +L+ K + + ++ V + ++ V+ L +K+ +F
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 878 NMLSSDLEKLRENLAD----MEAKFREKDERE-------EQLIKAKEKLEN-------DI 919
+ L ++ + + AD EA+ REK+ + E+ ++AKE+LE ++
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520
Query: 920 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK------ANENASF-LQKSIEDMT 972
+++ D + ++ R E +EE++ +L + A E+A L+ +++ +
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1580
Query: 973 VKAEQSQQEAAKKHEEEKKELERKL-------SDLEKKMETSHNQCQELKARYE----RA 1021
+ E+ Q +++EE++++L+R+L D K+ + ++L+ + +A
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
Query: 1022 TSETKTKHEEI--LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAED 1079
S K + E I L+ LQ + D + +L+ AR + +E K+A +A D
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-----D 1695
Query: 1080 AMQIMEQM-TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQ 1138
MQ+ E + E+ A LE +L EL + +E + + + +
Sbjct: 1696 LMQLQEDLAAAERARKQADLE-----KEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750
Query: 1139 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1198
++EE + +E + + +QQ L E LA E ++ ++ Q+LE + L ++
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNE---LATERSTAQKNESARQQLERQNKELRSK 1807
Query: 1199 LLEMKKR-ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS 1257
L EM+ +SKF +A + + EK A + L+ + L+ +
Sbjct: 1808 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1867
Query: 1258 LHSVVQTLESDKVKLELKVKNLELQL---KENKRQLSSSSGNTDTQADEDERAQESQIDF 1314
+ + + K +VK L+ QL +E ++++++ + DE + E+
Sbjct: 1868 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927
Query: 1315 LNSVIVDLQRKNQ 1327
+N++ L+R N+
Sbjct: 1928 VNALKSKLRRGNE 1940
Score = 172 bits (435), Expect = 3e-42
Identities = 222/958 (23%), Positives = 424/958 (44%), Gaps = 104/958 (10%)
Query: 436 RKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELE-DTRVAT 494
R+ E++Q + +E TK E Q K E+ +KELEQ + + LQ +L+ +T +
Sbjct: 856 RQEEEMQAKEDELQKTK---ERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 495 VSEKSRIMELEKDLALRVQEVA----ELRRRLESNKPAGDVDMS--LSLLQEISSLQEKL 548
+E+ R+ LA + QE+ E+ RLE + G + + Q++ L+E+L
Sbjct: 912 EAEEMRVR-----LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 549 EVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH--ANKENS 606
E Q+ + K A+ + + EI + KLSKE + L+ ++ N
Sbjct: 967 EEEEAARQK-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 607 DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL 666
+ A +KL+ H+ + EL+V K E +LK ++E D+ +I +L
Sbjct: 1026 EEKAKNLTKLKN---KHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 667 QNQQDSERAAHAKEMEALRAKLMKV---IKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
Q Q + AK+ E L+A L ++ I +K N+L+ IR + H+ ++++ L+
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL-----EGHISDLQEDLDS 1136
Query: 724 LQEAEIKVKEL-----EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
+ A K ++ E L+A E +D+ +Q + ++ ++ L+KA
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA------- 1189
Query: 779 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838
L ++ + E Q++ + +K+A++ +T +L+ + NL +N + + L
Sbjct: 1190 ---LDEETRSHEAQVQEMR-QKHAQA--VEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243
Query: 839 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 898
EL++L + E + ++ +QE +K E L+ + KL+ + +
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303
Query: 899 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKAN 958
E + + +L K L + + + ++ + + Q ++ +LR E + LQ +L +
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 959 ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARY 1018
E L++ I + ++ S+++ + + LE +K++E Q +E A Y
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKK-LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 1019 ERATSETKTKHEEILQNLQKTLLDTEDKL-----KGAREENSGLLQELEELRKQADKAKA 1073
++ +TK + ++ L +L LD + +L K R+ + L +E K AD+
Sbjct: 1423 DK-LEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 1074 AQT-AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL---KENNLKNVEELNKS 1129
A+ A + + + E L + E+ ++TN L+ E++ L K++ KNV EL KS
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 1130 KELLTVENQKMEEFRKEIETLKQAA---------------AQKSQQLSALQEENVKLAEE 1174
K L + ++M+ +E+E QA Q + L A E+N + +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 1175 LGRSRDEVTSHQKLEEER----------SVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1224
L R E + +LE+ER L L +++ + IK +E L+K
Sbjct: 1601 LQRQLHEYET--ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK-- 1656
Query: 1225 SITSALLTEKDAELEKL---RNEVTVLRGEN-ASAKSLHSVVQTLESDKVKLELKVKNLE 1280
A + + ELE R+E+ EN AKSL + + L+ D E K +
Sbjct: 1657 --LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 1281 LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
L+ +E +L+SS + DE R L + I L+ + ++ + +E MS+
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRR--------LEARIAQLEEELEEEQGNMEAMSD 1764
Score = 149 bits (376), Expect = 2e-35
Identities = 145/574 (25%), Positives = 259/574 (45%), Gaps = 54/574 (9%)
Query: 792 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 851
Q+ E E A+ + Q E +L L++ S++++ K L+++LQ E +AE
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 852 ASEEAVSVQRSMQETVNKLH-------QKEEQFNMLSSDLEKLRENLADMEAKFREKDER 904
A E V + QE LH ++E++ L ++ +K+ + + D+E + E++
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 905 EEQL----IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
++L + A+ K++ EI+ M N+ K++ E +L E + +L L + E
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNN----KLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
A L K +++ + KK E+ ++ELE+ LE H Q +L+A+
Sbjct: 1029 AKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 1021 ATSETKTKHEEI---LQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKAAQT 1076
+ K EE+ L L + + LK RE + E+L ++A + KA +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1077 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1136
D + +E + E +TL S ++ AK + E+ LK K ++E +S E E
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KALDEETRSHEAQVQE 1203
Query: 1137 -----NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE---LGRSRDEVTSHQKL 1188
Q +EE +++E K+A A + L++EN LA E LG+++ EV H+K
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKK 1262
Query: 1189 EEERSVLNNQLLEMKKRESKFIK-DADEEKASLQKSISITSALLTEKDAELEKLRNEVTV 1247
+ E V Q L+ K + + + + +++ LQ + + +L E + + KL +V
Sbjct: 1263 KLEAQV---QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV-- 1317
Query: 1248 LRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERA 1307
AS S Q L ++ + +L V QL+E + L Q DE+ A
Sbjct: 1318 -----ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEA 1365
Query: 1308 Q---ESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
+ E I LN + D ++K QD VE + E
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Score = 141 bits (355), Expect = 5e-33
Identities = 174/836 (20%), Positives = 352/836 (42%), Gaps = 119/836 (14%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
S + E ++A+ + T E K + ++++ + E A++A +G+ +Q
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESI 450
E+ + + V EL++K E A E + +++L+ E V + E ++I
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSD----GERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 451 TKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLAL 510
+ +EL Q +K R+LE+ R + + ME +++L
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE- 1370
Query: 511 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 570
+ ++ L +L +K LQ+ +S E LE + Q+EI +L
Sbjct: 1371 --RHISTLNIQLSDSK---------KKLQDFASTVEALEEGKKRFQKEIENL-------- 1411
Query: 571 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 630
T Q E KA A +KL K L QQ +++L
Sbjct: 1412 -TQQYEEKA--AAYDKLEKTKNRL-----------------------------QQELDDL 1439
Query: 631 KVSFSKGLGTETAEFAELKTQIEKMRLDYQH---EIENLQNQQDSERAAHAKEMEALRAK 687
V +L + +EK + + E +N+ ++ ER E K
Sbjct: 1440 VVDLDNQ--------RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491
Query: 688 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELE----VLQAKCNE 743
+ + + E +LEA + +L++ EMED ++ + V ELE L+ + E
Sbjct: 1492 ALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 744 QTKVIDNFTSQLKATEEKLLDLDA------------LRKASSEGKSEMKKLRQQLEAAEK 791
++ +L+ATE+ L L+ L+ + + + ++L++QL E
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 792 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 851
+++ ++ + + A++ ++L+G L +L+ + +E K+L+ L+ + +
Sbjct: 1611 ELE----DERKQRALAAAAKKKLEG---DLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 852 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 911
E + S E + E++ L +DL +L+E+LA E ++ D
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD-------LE 1716
Query: 912 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 971
KE+L ++A +SG N+ Q DE R E + +L+ +L + N + +
Sbjct: 1717 KEELAEELAS--SLSGRNALQ-----DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 972 TVKAEQ------SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSET 1025
T +AEQ +++ A+K+E +++LER+ +L K+ H +K++++ +
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL---HEMEGAVKSKFKSTIAAL 1826
Query: 1026 KTKHEEILQNLQKTLLDTEDKLKGAREENSGL---LQELEELRKQADKAKAAQTAEDAMQ 1082
+ K ++ + +++ + + K ++++ L L ++E+ RK A++ K + AE
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK--EQAEKGNA 1884
Query: 1083 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQ 1138
++Q+ ++ E + KLQ ELD E+N E+N K L N+
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 112 bits (281), Expect = 2e-24
Identities = 147/684 (21%), Positives = 281/684 (41%), Gaps = 92/684 (13%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
S TG+L E + + +L L++ Q+ +++ E + ++ + ++E+
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-------ETRQKLNVSTKLRQLEE 1350
Query: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN-QLEEEKRKVEDLQFRVEEES 449
E +D D+ E+EAK + R + LN QL + K+K++D VE +
Sbjct: 1351 ERNSLQDQLDE---EMEAKQNLER---------HISTLNIQLSDSKKKLQDFASTVE--A 1396
Query: 450 ITKGDLETQTKLEHARIKELEQSLLFEKTKADK--LQRELEDTRVATVSEKSRIMELEKD 507
+ +G Q ++E+ + E++ ++K + K LQ+EL+D V +++ + LEK
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 508 LALRVQEVAELRRRLESNKPAGDVDMS-----------LSLLQEIS-SLQEKLEVTRTD- 554
Q +AE + S+K A + D + LSL + + +L+ K E+ RT+
Sbjct: 1457 QRKFDQLLAEEKNI--SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 555 ----HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 610
++ S K+ G +K +AL T E++ + E L+ +L+
Sbjct: 1515 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA------ 1568
Query: 611 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 670
K +LE M+ LK F + L + E + Q+++ +Y+ E+E+ + Q+
Sbjct: 1569 --KLRLEVN-------MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 671 DSERAAHAK---EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT------- 720
AA K +++ L + IK +E +++ +R KL E+ED
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKDFQRELEDARASRDEI 1678
Query: 721 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD---------------- 764
+E E K K LE + E + Q +E+L +
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 765 ------LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
+ L + E + M+ + ++ A +Q + L E E S A Q E
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 819 LKLTNLQENLSEVS-QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877
+ L+ L E+ VK + + L+ K A+ E+ R Q L QK+++
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 878 NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN 937
+ +E R+ + + + + R +QL + E+ E + I +L +
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918
Query: 938 DELRLKERDVEELQLKLTKANENA 961
+ R+V L+ KL + NE +
Sbjct: 1919 ESNEAMGREVNALKSKLRRGNETS 1942
Score = 55.8 bits (133), Expect = 3e-07
Identities = 55/239 (23%), Positives = 99/239 (41%), Gaps = 48/239 (20%)
Query: 299 VMATTSASLKRSPS--ASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEA 356
+ AT + K++ S A + +A++ +R E + A +SG ALQ+
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1737
Query: 357 LKEKQQHIEQLLAERDLERA-------EVAKATSHVGEIEQELALARDGHDQH------- 402
+ + I QL E + E+ V KAT ++ ELA R ++
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 403 -------------------------VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRK 437
+ LEAK+ QL VE REK L+++ +K
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 438 VEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKAD-------KLQRELED 489
++++ +VE+E + Q + +AR+K+L++ L + ++ KLQREL++
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 176 bits (447), Expect = 1e-43
Identities = 224/1036 (21%), Positives = 469/1036 (45%), Gaps = 157/1036 (15%)
Query: 291 AKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGT 350
A+ A +R + + LK+ L+ ++ V + ++ LTE + I+
Sbjct: 936 AELTAKKRKLEDECSELKKDIDDLELT-LAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 994
Query: 351 TALQEALKEK-QQHIEQLLAERD----LERAEVA---KATSHVGEIEQELALARDGHDQH 402
T ++AL+E QQ ++ L E D L +++V + G +EQE + D ++
Sbjct: 995 TKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMD-LERA 1053
Query: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLE 462
+LE + + + + +K++L +L++++ + ++E+E + L+ + K
Sbjct: 1054 KRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKEN 1113
Query: 463 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRL 522
ARI+ELE+ L E+T ++++ +L DL+ ++E++E RL
Sbjct: 1114 QARIEELEEELEAERT------------------ARAKVEKLRSDLSRELEEISE---RL 1152
Query: 523 ESNKPAGDVDMSLSLLQ--EISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKAL 580
E A V + ++ + E ++ LE H+ +L++ ++I L
Sbjct: 1153 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1212
Query: 581 YTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKG--- 637
+KL KE K +L+ N + I K+ LE + + E +V +
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVT-SNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRS 1271
Query: 638 ----------LGTETAEFAE-------LKTQIEKMRLDYQHEIENLQNQQDSE------- 673
L TE E A L +Q+ + +L Y ++E+L+ Q + E
Sbjct: 1272 LNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNAL 1331
Query: 674 --------------RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMED 719
R + +E EA +A+L +V+ + + + R+K + Q E+E+
Sbjct: 1332 AHALQSARHDCDLLREQYEEETEA-KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEE 1390
Query: 720 TLNKL-QEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS------ 772
KL Q + + +E + AKC+ K +++ E+ ++D++ A+
Sbjct: 1391 AKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEI---EDLMVDVERSNAAAAALDKK 1447
Query: 773 --------SEGKSEMKKLRQQLEAAEKQIKHLEIE----KNAESSK---ASSITRELQGR 817
+E K + ++ + +LE+++K+ + L E KNA + RE +
Sbjct: 1448 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNL 1507
Query: 818 ELKLTNLQENLSEVSQVKETLE---KELQILKEKFAEASEEAVSVQRSMQETVNKLHQKE 874
+ ++++L E L E + LE K+L++ K + A EEA + S++ K+ + +
Sbjct: 1508 QEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEA---EASLEHEEGKILRAQ 1564
Query: 875 EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLT 934
+FN + +++E+ K EKDE EQ + +++ + + + ++
Sbjct: 1565 LEFNQIKAEIER----------KLAEKDEEMEQAKRNHQRVVDSLQTSL------DAETR 1608
Query: 935 KMNDELRLK---ERDVEELQLKLTKANENASFLQKSIEDM--TVKAEQSQQEAAKKHEEE 989
N+ LR+K E D+ E++++L+ AN A+ QK ++ + +K Q Q + A + ++
Sbjct: 1609 SRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD 1668
Query: 990 KKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQK---------TL 1040
KE ++ +E++ + +EL+A E+ K +E+++ ++ +L
Sbjct: 1669 LKE---NIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1725
Query: 1041 LDTEDKLKGAREENSGLLQE-LEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLE 1099
++ + K++ + ++E ++E R +KAK A T DA + E++ KE+ +T A LE
Sbjct: 1726 INQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAIT--DAAMMAEELKKEQ-DTSAHLE 1782
Query: 1100 DTK----QTNAKLQNELDTLKENNLK-NVEELNK-SKELLTVENQKMEEFRKEIETLK-- 1151
K QT LQ+ LD ++ LK ++L K + +E + E ++ E++K
Sbjct: 1783 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGM 1842
Query: 1152 QAAAQKSQQLSALQEEN----VKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRES 1207
+ + ++ ++L+ EE+ ++L + + + + +V ++++ EE N L K R+
Sbjct: 1843 RKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLS-KFRKV 1901
Query: 1208 KFIKDADEEKASLQKS 1223
+ D EE+A + +S
Sbjct: 1902 QHELDEAEERADIAES 1917
Score = 161 bits (408), Expect = 4e-39
Identities = 217/1037 (20%), Positives = 464/1037 (44%), Gaps = 117/1037 (11%)
Query: 387 EIEQELALARD--GHDQHVLEL-EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQF 443
E E+E+A ++ G + LE EA+ +L + + +EK +L Q++ E+ + D +
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905
Query: 444 RVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIME 503
R ++ K LE + K + R+++ E+ + +R+LED E S + +
Sbjct: 906 RCDQLIKNKIQLEAKVKEMNERLEDEEEM----NAELTAKKRKLED-------ECSELKK 954
Query: 504 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 563
DL L + +V E + NK + L + I+ L ++ + + HQ+ + L
Sbjct: 955 DIDDLELTLAKV-EKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL- 1012
Query: 564 EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASH 623
+ + ++ +L + KL ++ + L+ LE K D + K KLE +
Sbjct: 1013 -------QVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMD-LERAKRKLEGDLKLT 1064
Query: 624 QQAMEEL---KVSFSKGLGTETAEFAE----------LKTQIEKMRLDYQHEIENLQNQQ 670
Q+++ +L K+ + L + + + L Q++K + Q IE L+ +
Sbjct: 1065 QESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEEL 1124
Query: 671 DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 730
++ER A AK +E LR+ L + LE I +L++A V++E +NK +EAE +
Sbjct: 1125 EAERTARAK-VEKLRSDLSR-------ELEEISERLEEAGGATSVQIE--MNKKREAEFQ 1174
Query: 731 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE 790
++ +A + + E +D L++ + + E + + +L+
Sbjct: 1175 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT 1234
Query: 791 KQIKHLEIEKNAESSKASSITRELQGRE--LKLTNLQENLSEVSQVKETLEKE----LQI 844
++ + I+ A K S T E Q E +KL Q +L++ + + L+ E +
Sbjct: 1235 SNMEQI-IKAKANLEKVSR-TLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQ 1292
Query: 845 LKEK---FAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREK 901
L+EK ++ + +S + M++ +L ++ + N L+ L+ R + + ++ E+
Sbjct: 1293 LEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEE 1352
Query: 902 DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK--------ERDVEELQLK 953
E + +L + K +++A+ ++ Q T+ +E + K E VE + K
Sbjct: 1353 TEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAK 1412
Query: 954 LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK------ELERKLSDLEKKMETS 1007
+ + LQ IED+ V E+S AA ++++ E ++K + + ++E+S
Sbjct: 1413 CSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS 1472
Query: 1008 HNQCQ-------ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1060
+ + +LK YE + +T E +NLQ+ + D ++L E + E
Sbjct: 1473 QKEARSLSTELFKLKNAYEESLEHLETFKRE-NKNLQEEISDLTEQL----GEGGKNVHE 1527
Query: 1061 LEELRKQADKAK-----AAQTAEDAMQIME-QMTKEKTETLASLEDTKQTNAKLQNELDT 1114
LE++RKQ + K A + AE +++ E ++ + + E + ++ A+ E++
Sbjct: 1528 LEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1587
Query: 1115 LKENNLKNVEELNKSKELLTVENQKMEEFRKEIE-TLKQAAAQKS--QQLSALQEENVKL 1171
K N+ + V+ L S + T ++ +K++E L + Q S +++A ++ VK
Sbjct: 1588 AKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 1647
Query: 1172 AEELGRSR-----DEVTSHQKLEEERSVL--NNQLLEMKKRESKFIKDADEEKASLQKSI 1224
+ L + D V ++ L+E +++ N LL+ + E + + + E L
Sbjct: 1648 LQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL---- 1703
Query: 1225 SITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK 1284
+ EL + V +L +N SL + + +ESD +L+ +V+ + +
Sbjct: 1704 ---------AEQELIETSERVQLLHSQNT---SLINQKKKMESDLTQLQSEVEEAVQECR 1751
Query: 1285 ENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGN 1344
+ + + + A+E ++ Q++ L + ++++ +DL+ +++ + AL G
Sbjct: 1752 NAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNMEQTIKDLQHRLDEAEQIALKGG 1810
Query: 1345 GDDLNNYDSDDQEKQSK 1361
L ++ +E + +
Sbjct: 1811 KKQLQKLEARVRELEGE 1827
Score = 134 bits (338), Expect = 5e-31
Identities = 156/705 (22%), Positives = 302/705 (42%), Gaps = 78/705 (11%)
Query: 687 KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 746
K+ ++K E E K + + +E + K E++ K + +LQ K + Q +
Sbjct: 837 KIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRK----ELEEKMVSLLQEKNDLQLQ 892
Query: 747 VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK 806
V L EE+ D L K + ++++K++ ++LE E+ L +K +
Sbjct: 893 VQAE-QDNLNDAEERC---DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 948
Query: 807 ASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQET 866
S + +++ EL L +++ + L +E+ L E A+ ++E ++Q + Q+
Sbjct: 949 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1008
Query: 867 VNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS 926
++ L +E++ N LS KL + + D+E ++ + L +AK KLE D+ +
Sbjct: 1009 LDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068
Query: 927 GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE----- 981
D + ++ ++L+ KE D+ + K+ A LQK +++ + E+ ++E
Sbjct: 1069 MDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAER 1128
Query: 982 -AAKKHEEEKKELERKLSDLEKKMETS---------------------HNQCQELKARYE 1019
A K E+ + +L R+L ++ +++E + +E ++E
Sbjct: 1129 TARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE 1188
Query: 1020 RATSETKTKHE-------EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK-QADKA 1071
+ + KH E + NLQ+ E + + E + +E++ K +A+
Sbjct: 1189 ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE 1248
Query: 1072 KAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK---ENNLKNVEELNK 1128
K ++T ED Q E K + E SL D AKLQ E L E + +L +
Sbjct: 1249 KVSRTLED--QANEYRVKLE-EAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTR 1305
Query: 1129 SKELLTVENQKMEEFRKEIE---TLKQAAAQKSQ-----------QLSALQEENVKLAEE 1174
K T Q+ME+ ++++E K A A Q Q E +L
Sbjct: 1306 GKLSYT---QQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV 1362
Query: 1175 LGRSRDEVTS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1233
L ++ EV K E + +L E KK+ ++ ++DA+E ++ S
Sbjct: 1363 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHR 1422
Query: 1234 KDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSS 1293
E+E L +V NA+A +L + DK+ E K K E Q + Q +
Sbjct: 1423 LQNEIEDLMVDV---ERSNAAAAALDKKQRNF--DKILAEWKQKYEESQSELESSQKEAR 1477
Query: 1294 SGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
S T+ + + A E ++ L + +R+N++L+ ++ ++E
Sbjct: 1478 S--LSTELFKLKNAYEESLEHLET----FKRENKNLQEEISDLTE 1516
Score = 124 bits (310), Expect = 8e-28
Identities = 161/806 (19%), Positives = 355/806 (44%), Gaps = 76/806 (9%)
Query: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397
E S + G T++Q + +K++ Q + RDLE A + + E A R
Sbjct: 1146 EEISERLEEAGGATSVQIEMNKKREAEFQKM-RRDLEEATL--------QHEATAAALRK 1196
Query: 398 GHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDL-QFRVEEESITKGDLE 456
H V EL ++D L+ + + ++EK E +L++ +E + + + E +++ LE
Sbjct: 1197 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSR-TLE 1255
Query: 457 TQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVA 516
Q +++E ++SL T+ KLQ E + +++ I +L + Q++
Sbjct: 1256 DQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQME 1315
Query: 517 ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEH----FGAREET 572
+L+R+LE A + +L + S + ++ R ++ E + E A E
Sbjct: 1316 DLKRQLEEEGKAKN-----ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEV 1370
Query: 573 HQKEIKALYTA---TEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEE 629
Q K A TE+L + + L +L+ A +E + + S LE Q +E+
Sbjct: 1371 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDA-EEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 630 LKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM 689
L V + A + + +K+ +++ + E Q++ +S + KE +L +L
Sbjct: 1430 LMVDVERS-NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ----KEARSLSTELF 1484
Query: 690 KVIKEKENSLEAIRSKLDKAEDQHLVE-MEDTLNKLQEAEIKVKELEVLQAKCN----EQ 744
K+ E SLE + + K E+++L E + D +L E V ELE ++ + E
Sbjct: 1485 KLKNAYEESLEHLETF--KRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLEL 1542
Query: 745 TKVIDNFTSQLKATEEKLLDLDA-LRKASSEGKSEMKKLRQQLEAAEKQ----IKHLEIE 799
++ + L+ E K+L + +E + ++ + +++E A++ + L+
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
Query: 800 KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSV 859
+AE+ + + R + E L ++ LS +++ +K+++ L+ + +
Sbjct: 1603 LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1662
Query: 860 QRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFR-------EKDEREE------ 906
R+ + + E + N+L ++LE+LR + E + E ER +
Sbjct: 1663 VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1722
Query: 907 -QLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 965
LI K+K+E+D+ ++ + + ++ + D + +L K + ++ L+
Sbjct: 1723 TSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1782
Query: 966 K-------SIEDMTVKAEQSQQEAAK-------KHEEEKKELERKLSDLEKKMETSHNQC 1011
+ +I+D+ + ++++Q A K K E +ELE +L +K+ S
Sbjct: 1783 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGM 1842
Query: 1012 QELKARYERATSETK------TKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
++ + R + T +T+ + ++++ LQ + + + + A E+ + L + +++
Sbjct: 1843 RKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1902
Query: 1066 KQADKA-KAAQTAEDAMQIMEQMTKE 1090
+ D+A + A AE + + +++
Sbjct: 1903 HELDEAEERADIAESQVNKLRAKSRD 1928
Score = 102 bits (255), Expect = 2e-21
Identities = 123/601 (20%), Positives = 262/601 (43%), Gaps = 75/601 (12%)
Query: 332 RTGLLTETSSRYARKISGTTALQEALKEK-----------QQHIEQLLAERDLERAEVAK 380
RT L E + A+++ EA+ K Q IE L+ + + A A
Sbjct: 1384 RTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1443
Query: 381 ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK---VELLNQLEEEKRK 437
++ LA + +++ ELE+ + R++ + K E L LE KR+
Sbjct: 1444 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1503
Query: 438 VEDLQFRVEE--ESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATV 495
++LQ + + E + +G +LE R K+LE L +LQ LE+ +
Sbjct: 1504 NKNLQEEISDLTEQLGEGGKNVH-ELEKVR-KQLEVEKL-------ELQSALEEAEASLE 1554
Query: 496 SEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDH 555
E+ +I LR +LE N+ +++ ++++ E++E + +H
Sbjct: 1555 HEEGKI----------------LRAQLEFNQIKAEIE------RKLAEKDEEMEQAKRNH 1592
Query: 556 QREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK 615
QR + SL+ A + + ++ +K+ + ++ +L HAN+ ++
Sbjct: 1593 QRVVDSLQTSLDAETRSRNEVLRV----KKKMEGDLNEMEIQLSHANRMAAEA------- 1641
Query: 616 LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQ-QDSER 674
+ + S Q +++ ++ + + E +E+ Q E+E L+ + +ER
Sbjct: 1642 -QKQVKSLQSLLKDTQIQLDDAVRAND-DLKENIAIVERRNNLLQAELEELRAVVEQTER 1699
Query: 675 AAHAKEMEALR-AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 733
+ E E + ++ ++++ + SL + K++ Q E+E+ + + + AE K K+
Sbjct: 1700 SRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKK 1759
Query: 734 LEVLQAKCNEQTKVIDNFTSQL----KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA 789
A E+ K + ++ L K E+ + DL + + +K ++QL+
Sbjct: 1760 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ--HRLDEAEQIALKGGKKQLQKL 1817
Query: 790 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNL-------QENLSEVSQVKETLEKEL 842
E +++ LE E AE + + + ++ E ++ L ++NL + + + L+ ++
Sbjct: 1818 EARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKV 1877
Query: 843 QILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD 902
+ K + EA E+A + ++ ++L + EE+ ++ S + KLR D+ AK + D
Sbjct: 1878 KAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMHD 1937
Query: 903 E 903
E
Sbjct: 1938 E 1938
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 176 bits (445), Expect = 2e-43
Identities = 233/1074 (21%), Positives = 462/1074 (43%), Gaps = 149/1074 (13%)
Query: 358 KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMV 417
KE+QQ E L E + + +++ T ++++L Q EL A+ +++R +
Sbjct: 872 KERQQKAENELKELEQKHSQL---TEEKNLLQEQL--------QAETELYAEAEEMRVRL 920
Query: 418 EAADREKVELLNQ----LEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSL 473
A +E E+L++ LEEE+ + + LQ ++ + DLE Q + E A ++L+
Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 980
Query: 474 LFEKTKADKLQRE---LEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNK---- 526
+ + K KL+ E ++D E+ + E DL + E E + L K
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 527 -PAGDVDMSL----SLLQEISSLQEKLEVTRTDH-------QREITSLKEHFGAREETHQ 574
++++ L QE+ L+ KLE +D Q +I LK +EE Q
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100
Query: 575 KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELK--V 632
AL ++++++N +LK K+ SD+ + L++ A+ +A ++ +
Sbjct: 1101 ---AALARLDDEIAQKNNALK-KIRELEGHISDL----QEDLDSERAARNKAEKQKRDLG 1152
Query: 633 SFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVI 692
+ L TE + + +++R + E+ L+ D E +H +++ +R K + +
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 693 KEKENSLEAI---RSKLDKAEDQHLVEMEDTLNKL-------QEAEIKVKELEV----LQ 738
+E LE ++ LDK + E D +L QE E K K+LE LQ
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 739 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 798
+KC++ + ++ + +++++ +E + + KL + + + Q++ +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQN---EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329
Query: 799 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILK----------EK 848
E+ + +++ +L+ E + +LQ+ L E + K+ LE+ + L +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 849 FAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL 908
FA E ++ Q+ + L Q+ E+ LEK + L + + QL
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 909 IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI 968
+ EK + +++ + SS+ D + R+ E L L +A E A ++ +
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 969 E--DMTVKAEQSQQEAAKK------HEEEK---------KELERKLSDLEKKMETSHN-- 1009
E + +KAE ++K HE EK +E++ +L +LE +++ + +
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 1010 -----QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS-------GL 1057
Q LK ++ER ++EE + LQ+ L + E +L+ R++ + L
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117
+L++L QAD A + E+A++ + ++ + + LED + + ++ T KE
Sbjct: 1630 EGDLKDLELQAD--SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKE 1684
Query: 1118 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177
N K+K L Q E+ AAA+++++ + L++E +LAEEL
Sbjct: 1685 NE-------KKAKSLEADLMQLQEDL---------AAAERARKQADLEKE--ELAEELAS 1726
Query: 1178 SRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAE 1237
S N L + K+R I +EE Q ++ S + + +
Sbjct: 1727 SLSG--------------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 1238 LEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ----LSSS 1293
E+L NE L E ++A+ S Q LE +L K+ +E +K + L +
Sbjct: 1773 AEQLSNE---LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 1294 SGNTDTQADEDERAQESQIDFL---NSVIVDLQRKNQDLKMKVEMMSEAALNGN 1344
+ Q +++ R +++ L + + ++ + +D + E E A GN
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Score = 176 bits (445), Expect = 2e-43
Identities = 246/1073 (22%), Positives = 469/1073 (43%), Gaps = 147/1073 (13%)
Query: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ---ELALARDGHDQHVLELEAKM 410
+ LKE +Q QL E++L + ++ T E E+ LA + ++ + E+EA++
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 938
Query: 411 DQLRTMVEAADREKVELLNQLEEEKRKVE----DLQFRVEEESITKGDLETQTKLEHARI 466
+ E DR + QL+ E++K+ DL+ ++EEE + L+ + A+I
Sbjct: 939 E------EEEDRGQ-----QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 987
Query: 467 KELEQSLLFEKTKADKLQRE---LED------TRVATVSEKSR------------IMELE 505
K+LE +L + +KL +E LE+ T +A EK++ I ELE
Sbjct: 988 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Query: 506 KDLALRV---QEVAELRRRLESNKPAGDVDMSLSLLQ-EISSLQEKLEVTRTDHQREITS 561
L QE+ +L+R+LE + A D ++ LQ +I+ L+ +L + Q +
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGD--ASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 562 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV---IALWKSKLE- 617
L + A++ K+I+ L L ++ +S ++ A K+ D+ + K++LE
Sbjct: 1106 LDDEI-AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 618 ----TAIASHQQAMEELKVS-FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDS 672
TA +A E +V+ K L ET + Q+++MR + +E L Q +
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 673 ERAAHA----------KEMEALRAKLMKV------IKEKENSLEA----IRSKLDKAEDQ 712
+ A A KE L +L + ++ K+ LEA ++SK E
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 713 HLVEMEDTLNKLQ-EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE--------KLL 763
E+ D ++KLQ E E L + K + K + + +SQL+ T+E KL
Sbjct: 1282 R-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Query: 764 DLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHLEIEKNAESSKASSITRELQGRELK 820
LR+ E S +L +++EA E+ I L I+ + K ++ E
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 821 LTNLQ---ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877
Q ENL++ + K +L+ K + + ++ V + ++ V+ L +K+ +F
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 878 NMLSSDLEKLRENLAD----MEAKFREKDERE-------EQLIKAKEKLEN-------DI 919
+ L ++ + + AD EA+ REK+ + E+ ++AKE+LE ++
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520
Query: 920 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK------ANENASF-LQKSIEDMT 972
+++ D + ++ R E +EE++ +L + A E+A L+ +++ +
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1580
Query: 973 VKAEQSQQEAAKKHEEEKKELERKL-------SDLEKKMETSHNQCQELKARYE----RA 1021
+ E+ Q +++EE++++L+R+L D K+ + ++L+ + +A
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
Query: 1022 TSETKTKHEEI--LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAED 1079
S K + E I L+ LQ + D + +L+ AR + +E K+A +A D
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-----D 1695
Query: 1080 AMQIMEQM-TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQ 1138
MQ+ E + E+ A LE +L EL + +E + + + +
Sbjct: 1696 LMQLQEDLAAAERARKQADLE-----KEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750
Query: 1139 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1198
++EE + +E + + +QQ L E LA E ++ ++ Q+LE + L ++
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNE---LATERSTAQKNESARQQLERQNKELRSK 1807
Query: 1199 LLEMKKR-ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS 1257
L EM+ +SKF +A + + EK A + L+ + L+ +
Sbjct: 1808 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1867
Query: 1258 LHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQES 1310
+ + + K +VK L+ QL+E + + + N E + A ES
Sbjct: 1868 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Score = 172 bits (435), Expect = 3e-42
Identities = 222/958 (23%), Positives = 424/958 (44%), Gaps = 104/958 (10%)
Query: 436 RKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELE-DTRVAT 494
R+ E++Q + +E TK E Q K E+ +KELEQ + + LQ +L+ +T +
Sbjct: 856 RQEEEMQAKEDELQKTK---ERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 495 VSEKSRIMELEKDLALRVQEVA----ELRRRLESNKPAGDVDMS--LSLLQEISSLQEKL 548
+E+ R+ LA + QE+ E+ RLE + G + + Q++ L+E+L
Sbjct: 912 EAEEMRVR-----LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 549 EVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH--ANKENS 606
E Q+ + K A+ + + EI + KLSKE + L+ ++ N
Sbjct: 967 EEEEAARQK-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 607 DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL 666
+ A +KL+ H+ + EL+V K E +LK ++E D+ +I +L
Sbjct: 1026 EEKAKNLTKLKN---KHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 667 QNQQDSERAAHAKEMEALRAKLMKV---IKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
Q Q + AK+ E L+A L ++ I +K N+L+ IR + H+ ++++ L+
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL-----EGHISDLQEDLDS 1136
Query: 724 LQEAEIKVKEL-----EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
+ A K ++ E L+A E +D+ +Q + ++ ++ L+KA
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA------- 1189
Query: 779 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838
L ++ + E Q++ + +K+A++ +T +L+ + NL +N + + L
Sbjct: 1190 ---LDEETRSHEAQVQEMR-QKHAQA--VEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243
Query: 839 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 898
EL++L + E + ++ +QE +K E L+ + KL+ + +
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303
Query: 899 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKAN 958
E + + +L K L + + + ++ + + Q ++ +LR E + LQ +L +
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 959 ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARY 1018
E L++ I + ++ S+++ + + LE +K++E Q +E A Y
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKK-LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 1019 ERATSETKTKHEEILQNLQKTLLDTEDKL-----KGAREENSGLLQELEELRKQADKAKA 1073
++ +TK + ++ L +L LD + +L K R+ + L +E K AD+
Sbjct: 1423 DK-LEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 1074 AQT-AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL---KENNLKNVEELNKS 1129
A+ A + + + E L + E+ ++TN L+ E++ L K++ KNV EL KS
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 1130 KELLTVENQKMEEFRKEIETLKQAA---------------AQKSQQLSALQEENVKLAEE 1174
K L + ++M+ +E+E QA Q + L A E+N + +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 1175 LGRSRDEVTSHQKLEEER----------SVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1224
L R E + +LE+ER L L +++ + IK +E L+K
Sbjct: 1601 LQRQLHEYET--ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK-- 1656
Query: 1225 SITSALLTEKDAELEKL---RNEVTVLRGEN-ASAKSLHSVVQTLESDKVKLELKVKNLE 1280
A + + ELE R+E+ EN AKSL + + L+ D E K +
Sbjct: 1657 --LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 1281 LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
L+ +E +L+SS + DE R L + I L+ + ++ + +E MS+
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRR--------LEARIAQLEEELEEEQGNMEAMSD 1764
Score = 155 bits (391), Expect = 3e-37
Identities = 200/915 (21%), Positives = 390/915 (42%), Gaps = 135/915 (14%)
Query: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
L+ L +K++ ++ LA D E A+ A + E+E H+ +L+ +D
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG-----------HISDLQEDLDS 1136
Query: 413 LRTMVEAADREKVELLNQLEEEKRKVEDL-----------QFRVEEESITKGDLETQTKL 461
R A+++K +L +LE K ++ED R +E ++ K L+ +T+
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 462 EHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEK---DLALRVQEVAEL 518
A+++E+ Q ++L +LE + A + LEK DLA ++ + +
Sbjct: 1197 HEAQVQEMRQK---HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 519 RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF-GAREETHQKEI 577
++ +E K ++ + LQ S E+ D ++ + E G E K I
Sbjct: 1254 KQEVEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 578 KALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL--KVSFS 635
K L LS + + + L+ ++ +V + E + Q EE+ K +
Sbjct: 1312 K-LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 636 KGLGT----------ETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH---AKEME 682
+ + T + +FA +E+ + +Q EIENL Q + + AA+ K
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 683 ALRAKLMKVIKEKENSLEAIRSKLDKAE---DQHLVEMEDTLNKLQEAEIKVKELEVLQA 739
L+ +L ++ + +N + + S L+K + DQ L E ++ +K + E + +A
Sbjct: 1431 RLQQELDDLVVDLDNQRQLV-SNLEKKQRKFDQLLAEEKNISSKYAD------ERDRAEA 1483
Query: 740 KCNE-QTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 798
+ E +TK + S +A EE L + L + + K+EM+ L + K + LE
Sbjct: 1484 EAREKETKAL----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539
Query: 799 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA-------- 850
K A + +++ + +L L++ L K LE +Q LK +F
Sbjct: 1540 SKRA-------LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 851 EASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK 910
+ E+ +QR + E +L + +Q + ++ +KL +L D+E + + E+ IK
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 911 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 970
KL+ + + + D + ++ + E+ + L+ L + E+ + +++ +
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 971 MTVKAEQSQQEAAKKH------EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSE 1024
++ E+ +E A ++EK+ LE +++ LE+++E + + R +AT +
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 1025 TKTKHEEILQNLQKTLLDTEDKLKGAREE----NSGLLQELEELRKQ----------ADK 1070
E L N T T K + AR++ N L +L E+ A +
Sbjct: 1773 A-----EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 1071 AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSK 1130
AK AQ E +EQ +EK SL+ K+ LK +
Sbjct: 1828 AKIAQLEEQ----VEQEAREKQAATKSLKQ---------------KDKKLKEI------- 1861
Query: 1131 ELLTVENQK--MEEFRKEIETLKQAAAQKSQQLSALQEENVKL---AEELGRSRDEVT-S 1184
LL VE+++ E+++++ E Q +QL +EE+ ++ +L R DE T S
Sbjct: 1862 -LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Query: 1185 HQKLEEERSVLNNQL 1199
++ + E + L ++L
Sbjct: 1921 NEAMGREVNALKSKL 1935
Score = 155 bits (391), Expect = 3e-37
Identities = 180/840 (21%), Positives = 375/840 (44%), Gaps = 94/840 (11%)
Query: 348 SGTTALQEALKEKQQHIEQLLA-ERDLERAEVAKATSHV--GEIEQELALARDGHDQHVL 404
S A +A K+K+ E+L A + +LE + AT + EQE+ + + D+
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 405 ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESI-----------TKG 453
EA++ ++R A E E L Q + K ++ + +E+E+ K
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 454 DLETQTKLEHARIKEL-------EQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEK 506
++E + K A+++EL E++ K KLQ E+E + + ++L K
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 507 DLALRVQEVAELRRRL-ESNKPAGDVDMSLSLLQEI-SSLQEKLEV---TRTDHQREITS 561
D+A ++ + + L E + +V L L+E +SLQ++L+ + + +R I++
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 562 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA 621
L +K+++ + E L + + + ++E+ ++ + A + KLE
Sbjct: 1376 LNIQLS----DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-DKLEKTKN 1430
Query: 622 SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQH---EIENLQNQQDSERAAHA 678
QQ +++L V +L + +EK + + E +N+ ++ ER
Sbjct: 1431 RLQQELDDLVVDLDNQ--------RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 679 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELE--- 735
E K + + + E +LEA + +L++ EMED ++ + V ELE
Sbjct: 1483 AEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 736 -VLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA------------LRKASSEGKSEMKKL 782
L+ + E ++ +L+ATE+ L L+ L+ + + + ++L
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 783 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 842
++QL E +++ ++ + + A++ ++L+G L +L+ + +E K+L
Sbjct: 1602 QRQLHEYETELE----DERKQRALAAAAKKKLEG---DLKDLELQADSAIKGREEAIKQL 1654
Query: 843 QILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD 902
+ L+ + + E + S E + E++ L +DL +L+E+LA E ++ D
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 903 EREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENAS 962
KE+L ++A +SG N+ Q DE R E + +L+ +L + N
Sbjct: 1715 LE-------KEELAEELAS--SLSGRNALQ-----DEKRRLEARIAQLEEELEEEQGNME 1760
Query: 963 FLQKSIEDMTVKAEQ------SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA 1016
+ + T +AEQ +++ A+K+E +++LER+ +L K+ H +K+
Sbjct: 1761 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL---HEMEGAVKS 1817
Query: 1017 RYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL---LQELEELRKQADKAKA 1073
+++ + + K ++ + +++ + + K ++++ L L ++E+ RK A++ K
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK- 1876
Query: 1074 AQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELL 1133
+ AE ++Q+ ++ E + KLQ ELD E+N E+N K L
Sbjct: 1877 -EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 149 bits (376), Expect = 2e-35
Identities = 145/574 (25%), Positives = 259/574 (45%), Gaps = 54/574 (9%)
Query: 792 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 851
Q+ E E A+ + Q E +L L++ S++++ K L+++LQ E +AE
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 852 ASEEAVSVQRSMQETVNKLH-------QKEEQFNMLSSDLEKLRENLADMEAKFREKDER 904
A E V + QE LH ++E++ L ++ +K+ + + D+E + E++
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 905 EEQL----IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
++L + A+ K++ EI+ M N+ K++ E +L E + +L L + E
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNN----KLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
A L K +++ + KK E+ ++ELE+ LE H Q +L+A+
Sbjct: 1029 AKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 1021 ATSETKTKHEEI---LQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKAAQT 1076
+ K EE+ L L + + LK RE + E+L ++A + KA +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1077 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1136
D + +E + E +TL S ++ AK + E+ LK K ++E +S E E
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KALDEETRSHEAQVQE 1203
Query: 1137 -----NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE---LGRSRDEVTSHQKL 1188
Q +EE +++E K+A A + L++EN LA E LG+++ EV H+K
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKK 1262
Query: 1189 EEERSVLNNQLLEMKKRESKFIK-DADEEKASLQKSISITSALLTEKDAELEKLRNEVTV 1247
+ E V Q L+ K + + + + +++ LQ + + +L E + + KL +V
Sbjct: 1263 KLEAQV---QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV-- 1317
Query: 1248 LRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERA 1307
AS S Q L ++ + +L V QL+E + L Q DE+ A
Sbjct: 1318 -----ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEA 1365
Query: 1308 Q---ESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
+ E I LN + D ++K QD VE + E
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Score = 127 bits (320), Expect = 6e-29
Identities = 145/682 (21%), Positives = 302/682 (44%), Gaps = 83/682 (12%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
S TG+L E + + +L L++ Q+ +++ E + ++ + ++E+
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-------ETRQKLNVSTKLRQLEE 1350
Query: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN-QLEEEKRKVEDLQFRVEEES 449
E +D D+ E+EAK + R + LN QL + K+K++D VE +
Sbjct: 1351 ERNSLQDQLDE---EMEAKQNLER---------HISTLNIQLSDSKKKLQDFASTVE--A 1396
Query: 450 ITKGDLETQTKLEHARIKELEQSLLFEKTKADK--LQRELEDTRVATVSEKSRIMELEKD 507
+ +G Q ++E+ + E++ ++K + K LQ+EL+D V +++ + LEK
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 508 LALRVQEVAELRRRLESNKPAGDVDMS-----------LSLLQEIS-SLQEKLEVTRTD- 554
Q +AE + S+K A + D + LSL + + +L+ K E+ RT+
Sbjct: 1457 QRKFDQLLAEEKNI--SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 555 ----HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 610
++ S K+ G +K +AL T E++ + E L+ +L+
Sbjct: 1515 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA------ 1568
Query: 611 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 670
K +LE M+ LK F + L + E + Q+++ +Y+ E+E+ + Q+
Sbjct: 1569 --KLRLEVN-------MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 671 DSERAAHAK---EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA 727
AA K +++ L + IK +E +++ +R KL +M+D +L++A
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQ-------AQMKDFQRELEDA 1671
Query: 728 EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 787
E+ + ++ K ++ QL+ DL A +A + E ++L ++L
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQE------DLAAAERARKQADLEKEELAEELA 1725
Query: 788 AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 847
++ L+ EK ++ + + EL+ + + + + + + +Q E L EL +
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 848 KFAEASEEAVSVQRSMQETVNKLHQKEEQF-NMLSSDLEKLRENLADMEAKFREKDEREE 906
+ ++R +E +KLH+ E + S + L +A +E + ++ ++
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 907 QLIKAKEKLENDIAEIM-------KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 959
K+ ++ + + EI+ KM+ Q K N ++ +R +EE + + + N
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 960 NASFLQKSIEDMTVKAEQSQQE 981
N LQ+ +++ T E +E
Sbjct: 1906 NRRKLQRELDEATESNEAMGRE 1927
Score = 76.6 bits (187), Expect = 2e-13
Identities = 110/485 (22%), Positives = 206/485 (42%), Gaps = 93/485 (19%)
Query: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397
E + + +S AL+EAL+ K++ +E+ E ++ + VG+ EL ++
Sbjct: 1484 EAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 398 GHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVE-DLQFRVEEESITKGDLE 456
+ + E++ ++++L ++A + K+ L ++ K + E DLQ R E+ + L+
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 457 TQ-----TKLEHARI---------KELEQSLLFEKTKADK-------------------- 482
Q T+LE R K+LE L + +AD
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 483 -LQRELEDTRV------ATVSEKSR--------IMELEKDLALRVQEVAELRRRLESNKP 527
QRELED R AT E + +M+L++DLA E A + LE +
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA--AAERARKQADLEKEEL 1720
Query: 528 AGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA-----REETHQKEIKALYT 582
A ++ SLS + + +LE + E+ + + A R+ T Q E +
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 583 ATEK-LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTE 641
ATE+ +++NES + +LE NKE +SKL + +K F +
Sbjct: 1781 ATERSTAQKNESARQQLERQNKE-------LRSKL-------HEMEGAVKSKFKSTIAAL 1826
Query: 642 TAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA 701
A+ A+L+ Q+E Q+ E+ A K ++ KL +++ + E+ +
Sbjct: 1827 EAKIAQLEEQVE---------------QEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 702 IRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV----LQAKCNEQTKVIDNFTSQLKA 757
++AE + ++ +L+EAE + + + LQ + +E T+ + ++ A
Sbjct: 1872 AEQYKEQAEKGN-ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 758 TEEKL 762
+ KL
Sbjct: 1931 LKSKL 1935
Score = 55.8 bits (133), Expect = 3e-07
Identities = 55/239 (23%), Positives = 99/239 (41%), Gaps = 48/239 (20%)
Query: 299 VMATTSASLKRSPS--ASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEA 356
+ AT + K++ S A + +A++ +R E + A +SG ALQ+
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1737
Query: 357 LKEKQQHIEQLLAERDLERA-------EVAKATSHVGEIEQELALARDGHDQH------- 402
+ + I QL E + E+ V KAT ++ ELA R ++
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 403 -------------------------VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRK 437
+ LEAK+ QL VE REK L+++ +K
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 438 VEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKAD-------KLQRELED 489
++++ +VE+E + Q + +AR+K+L++ L + ++ KLQREL++
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 176 bits (445), Expect = 2e-43
Identities = 233/1074 (21%), Positives = 462/1074 (43%), Gaps = 149/1074 (13%)
Query: 358 KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMV 417
KE+QQ E L E + + +++ T ++++L Q EL A+ +++R +
Sbjct: 865 KERQQKAENELKELEQKHSQL---TEEKNLLQEQL--------QAETELYAEAEEMRVRL 913
Query: 418 EAADREKVELLNQ----LEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSL 473
A +E E+L++ LEEE+ + + LQ ++ + DLE Q + E A ++L+
Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 973
Query: 474 LFEKTKADKLQRE---LEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNK---- 526
+ + K KL+ E ++D E+ + E DL + E E + L K
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 527 -PAGDVDMSL----SLLQEISSLQEKLEVTRTDH-------QREITSLKEHFGAREETHQ 574
++++ L QE+ L+ KLE +D Q +I LK +EE Q
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093
Query: 575 KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELK--V 632
AL ++++++N +LK K+ SD+ + L++ A+ +A ++ +
Sbjct: 1094 ---AALARLDDEIAQKNNALK-KIRELEGHISDL----QEDLDSERAARNKAEKQKRDLG 1145
Query: 633 SFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVI 692
+ L TE + + +++R + E+ L+ D E +H +++ +R K + +
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 693 KEKENSLEAI---RSKLDKAEDQHLVEMEDTLNKL-------QEAEIKVKELEV----LQ 738
+E LE ++ LDK + E D +L QE E K K+LE LQ
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 739 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 798
+KC++ + ++ + +++++ +E + + KL + + + Q++ +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQN---EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322
Query: 799 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILK----------EK 848
E+ + +++ +L+ E + +LQ+ L E + K+ LE+ + L +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 849 FAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL 908
FA E ++ Q+ + L Q+ E+ LEK + L + + QL
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 909 IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI 968
+ EK + +++ + SS+ D + R+ E L L +A E A ++ +
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 969 E--DMTVKAEQSQQEAAKK------HEEEK---------KELERKLSDLEKKMETSHN-- 1009
E + +KAE ++K HE EK +E++ +L +LE +++ + +
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 1010 -----QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS-------GL 1057
Q LK ++ER ++EE + LQ+ L + E +L+ R++ + L
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117
+L++L QAD A + E+A++ + ++ + + LED + + ++ T KE
Sbjct: 1623 EGDLKDLELQAD--SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKE 1677
Query: 1118 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177
N K+K L Q E+ AAA+++++ + L++E +LAEEL
Sbjct: 1678 NE-------KKAKSLEADLMQLQEDL---------AAAERARKQADLEKE--ELAEELAS 1719
Query: 1178 SRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAE 1237
S N L + K+R I +EE Q ++ S + + +
Sbjct: 1720 SLSG--------------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 1238 LEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ----LSSS 1293
E+L NE L E ++A+ S Q LE +L K+ +E +K + L +
Sbjct: 1766 AEQLSNE---LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 1294 SGNTDTQADEDERAQESQIDFL---NSVIVDLQRKNQDLKMKVEMMSEAALNGN 1344
+ Q +++ R +++ L + + ++ + +D + E E A GN
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Score = 176 bits (445), Expect = 2e-43
Identities = 246/1073 (22%), Positives = 469/1073 (43%), Gaps = 147/1073 (13%)
Query: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ---ELALARDGHDQHVLELEAKM 410
+ LKE +Q QL E++L + ++ T E E+ LA + ++ + E+EA++
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 931
Query: 411 DQLRTMVEAADREKVELLNQLEEEKRKVE----DLQFRVEEESITKGDLETQTKLEHARI 466
+ E DR + QL+ E++K+ DL+ ++EEE + L+ + A+I
Sbjct: 932 E------EEEDRGQ-----QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 980
Query: 467 KELEQSLLFEKTKADKLQRE---LED------TRVATVSEKSR------------IMELE 505
K+LE +L + +KL +E LE+ T +A EK++ I ELE
Sbjct: 981 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Query: 506 KDLALRV---QEVAELRRRLESNKPAGDVDMSLSLLQ-EISSLQEKLEVTRTDHQREITS 561
L QE+ +L+R+LE + A D ++ LQ +I+ L+ +L + Q +
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGD--ASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 562 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV---IALWKSKLE- 617
L + A++ K+I+ L L ++ +S ++ A K+ D+ + K++LE
Sbjct: 1099 LDDEI-AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 618 ----TAIASHQQAMEELKVS-FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDS 672
TA +A E +V+ K L ET + Q+++MR + +E L Q +
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 673 ERAAHA----------KEMEALRAKLMKV------IKEKENSLEA----IRSKLDKAEDQ 712
+ A A KE L +L + ++ K+ LEA ++SK E
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 713 HLVEMEDTLNKLQ-EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE--------KLL 763
E+ D ++KLQ E E L + K + K + + +SQL+ T+E KL
Sbjct: 1275 R-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Query: 764 DLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHLEIEKNAESSKASSITRELQGRELK 820
LR+ E S +L +++EA E+ I L I+ + K ++ E
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 821 LTNLQ---ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877
Q ENL++ + K +L+ K + + ++ V + ++ V+ L +K+ +F
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 878 NMLSSDLEKLRENLAD----MEAKFREKDERE-------EQLIKAKEKLEN-------DI 919
+ L ++ + + AD EA+ REK+ + E+ ++AKE+LE ++
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513
Query: 920 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK------ANENASF-LQKSIEDMT 972
+++ D + ++ R E +EE++ +L + A E+A L+ +++ +
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1573
Query: 973 VKAEQSQQEAAKKHEEEKKELERKL-------SDLEKKMETSHNQCQELKARYE----RA 1021
+ E+ Q +++EE++++L+R+L D K+ + ++L+ + +A
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1633
Query: 1022 TSETKTKHEEI--LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAED 1079
S K + E I L+ LQ + D + +L+ AR + +E K+A +A D
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-----D 1688
Query: 1080 AMQIMEQM-TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQ 1138
MQ+ E + E+ A LE +L EL + +E + + + +
Sbjct: 1689 LMQLQEDLAAAERARKQADLE-----KEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743
Query: 1139 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1198
++EE + +E + + +QQ L E LA E ++ ++ Q+LE + L ++
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNE---LATERSTAQKNESARQQLERQNKELRSK 1800
Query: 1199 LLEMKKR-ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS 1257
L EM+ +SKF +A + + EK A + L+ + L+ +
Sbjct: 1801 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1860
Query: 1258 LHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQES 1310
+ + + K +VK L+ QL+E + + + N E + A ES
Sbjct: 1861 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Score = 172 bits (435), Expect = 3e-42
Identities = 222/958 (23%), Positives = 424/958 (44%), Gaps = 104/958 (10%)
Query: 436 RKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELE-DTRVAT 494
R+ E++Q + +E TK E Q K E+ +KELEQ + + LQ +L+ +T +
Sbjct: 849 RQEEEMQAKEDELQKTK---ERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 495 VSEKSRIMELEKDLALRVQEVA----ELRRRLESNKPAGDVDMS--LSLLQEISSLQEKL 548
+E+ R+ LA + QE+ E+ RLE + G + + Q++ L+E+L
Sbjct: 905 EAEEMRVR-----LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 549 EVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH--ANKENS 606
E Q+ + K A+ + + EI + KLSKE + L+ ++ N
Sbjct: 960 EEEEAARQK-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 607 DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL 666
+ A +KL+ H+ + EL+V K E +LK ++E D+ +I +L
Sbjct: 1019 EEKAKNLTKLKN---KHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 667 QNQQDSERAAHAKEMEALRAKLMKV---IKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
Q Q + AK+ E L+A L ++ I +K N+L+ IR + H+ ++++ L+
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL-----EGHISDLQEDLDS 1129
Query: 724 LQEAEIKVKEL-----EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
+ A K ++ E L+A E +D+ +Q + ++ ++ L+KA
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA------- 1182
Query: 779 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838
L ++ + E Q++ + +K+A++ +T +L+ + NL +N + + L
Sbjct: 1183 ---LDEETRSHEAQVQEMR-QKHAQA--VEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236
Query: 839 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 898
EL++L + E + ++ +QE +K E L+ + KL+ + +
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296
Query: 899 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKAN 958
E + + +L K L + + + ++ + + Q ++ +LR E + LQ +L +
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 959 ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARY 1018
E L++ I + ++ S+++ + + LE +K++E Q +E A Y
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKK-LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 1019 ERATSETKTKHEEILQNLQKTLLDTEDKL-----KGAREENSGLLQELEELRKQADKAKA 1073
++ +TK + ++ L +L LD + +L K R+ + L +E K AD+
Sbjct: 1416 DK-LEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 1074 AQT-AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL---KENNLKNVEELNKS 1129
A+ A + + + E L + E+ ++TN L+ E++ L K++ KNV EL KS
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 1130 KELLTVENQKMEEFRKEIETLKQAA---------------AQKSQQLSALQEENVKLAEE 1174
K L + ++M+ +E+E QA Q + L A E+N + +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 1175 LGRSRDEVTSHQKLEEER----------SVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1224
L R E + +LE+ER L L +++ + IK +E L+K
Sbjct: 1594 LQRQLHEYET--ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK-- 1649
Query: 1225 SITSALLTEKDAELEKL---RNEVTVLRGEN-ASAKSLHSVVQTLESDKVKLELKVKNLE 1280
A + + ELE R+E+ EN AKSL + + L+ D E K +
Sbjct: 1650 --LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 1281 LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
L+ +E +L+SS + DE R L + I L+ + ++ + +E MS+
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRR--------LEARIAQLEEELEEEQGNMEAMSD 1757
Score = 155 bits (391), Expect = 3e-37
Identities = 200/915 (21%), Positives = 390/915 (42%), Gaps = 135/915 (14%)
Query: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
L+ L +K++ ++ LA D E A+ A + E+E H+ +L+ +D
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG-----------HISDLQEDLDS 1129
Query: 413 LRTMVEAADREKVELLNQLEEEKRKVEDL-----------QFRVEEESITKGDLETQTKL 461
R A+++K +L +LE K ++ED R +E ++ K L+ +T+
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 462 EHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEK---DLALRVQEVAEL 518
A+++E+ Q ++L +LE + A + LEK DLA ++ + +
Sbjct: 1190 HEAQVQEMRQK---HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 519 RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF-GAREETHQKEI 577
++ +E K ++ + LQ S E+ D ++ + E G E K I
Sbjct: 1247 KQEVEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 578 KALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL--KVSFS 635
K L LS + + + L+ ++ +V + E + Q EE+ K +
Sbjct: 1305 K-LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 636 KGLGT----------ETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH---AKEME 682
+ + T + +FA +E+ + +Q EIENL Q + + AA+ K
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 683 ALRAKLMKVIKEKENSLEAIRSKLDKAE---DQHLVEMEDTLNKLQEAEIKVKELEVLQA 739
L+ +L ++ + +N + + S L+K + DQ L E ++ +K + E + +A
Sbjct: 1424 RLQQELDDLVVDLDNQRQLV-SNLEKKQRKFDQLLAEEKNISSKYAD------ERDRAEA 1476
Query: 740 KCNE-QTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 798
+ E +TK + S +A EE L + L + + K+EM+ L + K + LE
Sbjct: 1477 EAREKETKAL----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532
Query: 799 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA-------- 850
K A + +++ + +L L++ L K LE +Q LK +F
Sbjct: 1533 SKRA-------LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585
Query: 851 EASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK 910
+ E+ +QR + E +L + +Q + ++ +KL +L D+E + + E+ IK
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 911 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 970
KL+ + + + D + ++ + E+ + L+ L + E+ + +++ +
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 971 MTVKAEQSQQEAAKKH------EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSE 1024
++ E+ +E A ++EK+ LE +++ LE+++E + + R +AT +
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 1025 TKTKHEEILQNLQKTLLDTEDKLKGAREE----NSGLLQELEELRKQ----------ADK 1070
E L N T T K + AR++ N L +L E+ A +
Sbjct: 1766 A-----EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 1071 AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSK 1130
AK AQ E +EQ +EK SL+ K+ LK +
Sbjct: 1821 AKIAQLEEQ----VEQEAREKQAATKSLKQ---------------KDKKLKEI------- 1854
Query: 1131 ELLTVENQK--MEEFRKEIETLKQAAAQKSQQLSALQEENVKL---AEELGRSRDEVT-S 1184
LL VE+++ E+++++ E Q +QL +EE+ ++ +L R DE T S
Sbjct: 1855 -LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Query: 1185 HQKLEEERSVLNNQL 1199
++ + E + L ++L
Sbjct: 1914 NEAMGREVNALKSKL 1928
Score = 155 bits (391), Expect = 3e-37
Identities = 180/840 (21%), Positives = 375/840 (44%), Gaps = 94/840 (11%)
Query: 348 SGTTALQEALKEKQQHIEQLLA-ERDLERAEVAKATSHV--GEIEQELALARDGHDQHVL 404
S A +A K+K+ E+L A + +LE + AT + EQE+ + + D+
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 405 ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESI-----------TKG 453
EA++ ++R A E E L Q + K ++ + +E+E+ K
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 454 DLETQTKLEHARIKEL-------EQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEK 506
++E + K A+++EL E++ K KLQ E+E + + ++L K
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 507 DLALRVQEVAELRRRL-ESNKPAGDVDMSLSLLQEI-SSLQEKLEV---TRTDHQREITS 561
D+A ++ + + L E + +V L L+E +SLQ++L+ + + +R I++
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 562 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA 621
L +K+++ + E L + + + ++E+ ++ + A + KLE
Sbjct: 1369 LNIQLS----DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-DKLEKTKN 1423
Query: 622 SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQH---EIENLQNQQDSERAAHA 678
QQ +++L V +L + +EK + + E +N+ ++ ER
Sbjct: 1424 RLQQELDDLVVDLDNQ--------RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 679 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELE--- 735
E K + + + E +LEA + +L++ EMED ++ + V ELE
Sbjct: 1476 AEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534
Query: 736 -VLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA------------LRKASSEGKSEMKKL 782
L+ + E ++ +L+ATE+ L L+ L+ + + + ++L
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594
Query: 783 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 842
++QL E +++ ++ + + A++ ++L+G L +L+ + +E K+L
Sbjct: 1595 QRQLHEYETELE----DERKQRALAAAAKKKLEG---DLKDLELQADSAIKGREEAIKQL 1647
Query: 843 QILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD 902
+ L+ + + E + S E + E++ L +DL +L+E+LA E ++ D
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 903 EREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENAS 962
KE+L ++A +SG N+ Q DE R E + +L+ +L + N
Sbjct: 1708 LE-------KEELAEELAS--SLSGRNALQ-----DEKRRLEARIAQLEEELEEEQGNME 1753
Query: 963 FLQKSIEDMTVKAEQ------SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA 1016
+ + T +AEQ +++ A+K+E +++LER+ +L K+ H +K+
Sbjct: 1754 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL---HEMEGAVKS 1810
Query: 1017 RYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL---LQELEELRKQADKAKA 1073
+++ + + K ++ + +++ + + K ++++ L L ++E+ RK A++ K
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK- 1869
Query: 1074 AQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELL 1133
+ AE ++Q+ ++ E + KLQ ELD E+N E+N K L
Sbjct: 1870 -EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 149 bits (376), Expect = 2e-35
Identities = 145/574 (25%), Positives = 259/574 (45%), Gaps = 54/574 (9%)
Query: 792 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 851
Q+ E E A+ + Q E +L L++ S++++ K L+++LQ E +AE
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 852 ASEEAVSVQRSMQETVNKLH-------QKEEQFNMLSSDLEKLRENLADMEAKFREKDER 904
A E V + QE LH ++E++ L ++ +K+ + + D+E + E++
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 905 EEQL----IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
++L + A+ K++ EI+ M N+ K++ E +L E + +L L + E
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNN----KLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
A L K +++ + KK E+ ++ELE+ LE H Q +L+A+
Sbjct: 1022 AKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 1021 ATSETKTKHEEI---LQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKAAQT 1076
+ K EE+ L L + + LK RE + E+L ++A + KA +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1077 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1136
D + +E + E +TL S ++ AK + E+ LK K ++E +S E E
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KALDEETRSHEAQVQE 1196
Query: 1137 -----NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE---LGRSRDEVTSHQKL 1188
Q +EE +++E K+A A + L++EN LA E LG+++ EV H+K
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKK 1255
Query: 1189 EEERSVLNNQLLEMKKRESKFIK-DADEEKASLQKSISITSALLTEKDAELEKLRNEVTV 1247
+ E V Q L+ K + + + + +++ LQ + + +L E + + KL +V
Sbjct: 1256 KLEAQV---QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV-- 1310
Query: 1248 LRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERA 1307
AS S Q L ++ + +L V QL+E + L Q DE+ A
Sbjct: 1311 -----ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEA 1358
Query: 1308 Q---ESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
+ E I LN + D ++K QD VE + E
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Score = 127 bits (320), Expect = 6e-29
Identities = 145/682 (21%), Positives = 302/682 (44%), Gaps = 83/682 (12%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
S TG+L E + + +L L++ Q+ +++ E + ++ + ++E+
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-------ETRQKLNVSTKLRQLEE 1343
Query: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN-QLEEEKRKVEDLQFRVEEES 449
E +D D+ E+EAK + R + LN QL + K+K++D VE +
Sbjct: 1344 ERNSLQDQLDE---EMEAKQNLER---------HISTLNIQLSDSKKKLQDFASTVE--A 1389
Query: 450 ITKGDLETQTKLEHARIKELEQSLLFEKTKADK--LQRELEDTRVATVSEKSRIMELEKD 507
+ +G Q ++E+ + E++ ++K + K LQ+EL+D V +++ + LEK
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 508 LALRVQEVAELRRRLESNKPAGDVDMS-----------LSLLQEIS-SLQEKLEVTRTD- 554
Q +AE + S+K A + D + LSL + + +L+ K E+ RT+
Sbjct: 1450 QRKFDQLLAEEKNI--SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 555 ----HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 610
++ S K+ G +K +AL T E++ + E L+ +L+
Sbjct: 1508 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA------ 1561
Query: 611 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 670
K +LE M+ LK F + L + E + Q+++ +Y+ E+E+ + Q+
Sbjct: 1562 --KLRLEVN-------MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 671 DSERAAHAK---EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA 727
AA K +++ L + IK +E +++ +R KL +M+D +L++A
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQ-------AQMKDFQRELEDA 1664
Query: 728 EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 787
E+ + ++ K ++ QL+ DL A +A + E ++L ++L
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQE------DLAAAERARKQADLEKEELAEELA 1718
Query: 788 AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 847
++ L+ EK ++ + + EL+ + + + + + + +Q E L EL +
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 848 KFAEASEEAVSVQRSMQETVNKLHQKEEQF-NMLSSDLEKLRENLADMEAKFREKDEREE 906
+ ++R +E +KLH+ E + S + L +A +E + ++ ++
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 907 QLIKAKEKLENDIAEIM-------KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 959
K+ ++ + + EI+ KM+ Q K N ++ +R +EE + + + N
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 960 NASFLQKSIEDMTVKAEQSQQE 981
N LQ+ +++ T E +E
Sbjct: 1899 NRRKLQRELDEATESNEAMGRE 1920
Score = 76.6 bits (187), Expect = 2e-13
Identities = 110/485 (22%), Positives = 206/485 (42%), Gaps = 93/485 (19%)
Query: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397
E + + +S AL+EAL+ K++ +E+ E ++ + VG+ EL ++
Sbjct: 1477 EAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 398 GHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVE-DLQFRVEEESITKGDLE 456
+ + E++ ++++L ++A + K+ L ++ K + E DLQ R E+ + L+
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 457 TQ-----TKLEHARI---------KELEQSLLFEKTKADK-------------------- 482
Q T+LE R K+LE L + +AD
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 483 -LQRELEDTRV------ATVSEKSR--------IMELEKDLALRVQEVAELRRRLESNKP 527
QRELED R AT E + +M+L++DLA E A + LE +
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA--AAERARKQADLEKEEL 1713
Query: 528 AGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA-----REETHQKEIKALYT 582
A ++ SLS + + +LE + E+ + + A R+ T Q E +
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 583 ATEK-LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTE 641
ATE+ +++NES + +LE NKE +SKL + +K F +
Sbjct: 1774 ATERSTAQKNESARQQLERQNKE-------LRSKL-------HEMEGAVKSKFKSTIAAL 1819
Query: 642 TAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA 701
A+ A+L+ Q+E Q+ E+ A K ++ KL +++ + E+ +
Sbjct: 1820 EAKIAQLEEQVE---------------QEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 702 IRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV----LQAKCNEQTKVIDNFTSQLKA 757
++AE + ++ +L+EAE + + + LQ + +E T+ + ++ A
Sbjct: 1865 AEQYKEQAEKGN-ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 758 TEEKL 762
+ KL
Sbjct: 1924 LKSKL 1928
Score = 55.8 bits (133), Expect = 3e-07
Identities = 55/239 (23%), Positives = 99/239 (41%), Gaps = 48/239 (20%)
Query: 299 VMATTSASLKRSPS--ASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEA 356
+ AT + K++ S A + +A++ +R E + A +SG ALQ+
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1730
Query: 357 LKEKQQHIEQLLAERDLERA-------EVAKATSHVGEIEQELALARDGHDQH------- 402
+ + I QL E + E+ V KAT ++ ELA R ++
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 403 -------------------------VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRK 437
+ LEAK+ QL VE REK L+++ +K
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 438 VEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKAD-------KLQRELED 489
++++ +VE+E + Q + +AR+K+L++ L + ++ KLQREL++
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 175 bits (443), Expect = 3e-43
Identities = 249/1156 (21%), Positives = 500/1156 (43%), Gaps = 154/1156 (13%)
Query: 288 PAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKI 347
PA A + +++AS+K + +++ S S L+E +I
Sbjct: 1705 PAGDTAKECMETLLSSNASMKEELERVKME-YETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Query: 348 SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD---------- 397
G + Q L+ ++H Q + S GE E++ +L+
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVTEE-------GTQSIPGETEEQDSLSMSTRPTCSESVP 1816
Query: 398 --------------GHDQHVLELEAKMDQLRTMVEAADREKV---ELLNQLEEEKRKV-- 438
HD+ L+ ++DQL+ + + EK E LE EK +
Sbjct: 1817 SAKSANPAVSKDFSSHDEINNYLQ-QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLS 1875
Query: 439 ----EDLQFRVEEESITKGDL-ETQTKLEHARIKELEQSLLFEKTKAD-KLQRELEDTR- 491
+D + ++ +E +TK +L Q + E +R+ +L+++ EK + +L +L +
Sbjct: 1876 QISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNG 1935
Query: 492 --------VATVSEKSRIMELE-KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEIS 542
V K+ ++E E K+L V E+ E +++L K + ++ L++I
Sbjct: 1936 SIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQ 1995
Query: 543 SLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTAT----EKLSKENESLKSKL 598
Q+ E H +E+ L + Q+E+K L EK+S ++K+ L
Sbjct: 1996 GAQK--EPGNKSHAKELQELLKE-------KQQEVKQLQKDCIRYQEKISALERTVKA-L 2045
Query: 599 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 658
E E+ + + K L A+ ++A EL SF L +E A + K++ +
Sbjct: 2046 EFVQTESQKDLEITKENLAQAVEHRKKAQAEL-ASFKVLLDDTQSEAARVLADNLKLKKE 2104
Query: 659 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 718
Q E++++Q + + +E K +K K + L+A+R + E+ + E++
Sbjct: 2105 LQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEET-IGEIQ 2163
Query: 719 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
TLNK K KE++ LQ + + FT + + ++ D D + E K
Sbjct: 2164 VTLNK------KDKEVQQLQENLDSTVTQLAAFTKSMSSLQD---DRD---RVIDEAKKW 2211
Query: 779 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838
+K +++ E++I+ E S + +L+ + + L+ N+S + K+
Sbjct: 2212 ERKFSDAIQSKEEEIRLKE-------DNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
Query: 839 EKELQI---LKEKFAEASE-EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADM 894
E + Q L++K + + E + ++ET + H + + L S+L+ L++ L D+
Sbjct: 2265 ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
Query: 895 EAKFREKDEREEQLIKAKEKLENDIA------EIMKMSGDNSSQLT-KMNDELRLKERDV 947
+ E++ L + E DI E ++ S +LT ++++E+ +KE+ +
Sbjct: 2325 SNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI 2384
Query: 948 --------EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 999
E +Q+ + + + K I+++ Q ++E EE KK ++ K +
Sbjct: 2385 ISLLSGKEEAIQVAIAELRQQHD---KEIKELENLLSQEEEENIVLEEENKKAVD-KTNQ 2440
Query: 1000 LEKKMETSHNQCQELKARYE---RATSETKTKHEEILQNLQKT-------LLDTEDKLKG 1049
L + ++T + + KA+ + ++ S + + I+ + Q+ +L+ + ++
Sbjct: 2441 LMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQE 2500
Query: 1050 AREENSGLLQELEELRKQADKAKAAQTAEDAMQIM------EQMTKEKTETLASLEDTKQ 1103
A EN+ L +E+ LR D + DA I + +T + ++ LE Q
Sbjct: 2501 AAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQ 2560
Query: 1104 TNAKLQNELDTLKENNLKNVEELNKS-KELLTVENQKMEEFRKEIETLKQAAAQKSQQLS 1162
N +L+N+ L+E LK EE N+ + ++ ++ KEIE+LK + +Q ++Q++
Sbjct: 2561 QNKELENKYAKLEEK-LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVT 2619
Query: 1163 ALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK 1222
ALQEE LG ++ K++EE ++L + K I + +EE +QK
Sbjct: 2620 ALQEEGT-----LGLYHAQL----KVKEEEV---HRLSALFSSSQKRIAELEEELVCVQK 2667
Query: 1223 SISITSALLTEK-DAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKV----- 1276
+ + +K EL+ L ++ ++R E +A+ V L D V++E K+
Sbjct: 2668 EAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEER---VAELARDLVEMEQKLLMVTK 2724
Query: 1277 --KNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVE 1334
K L Q++ R +SS + D A+E+ + + D + L+ + + +
Sbjct: 2725 ENKGLTAQIQSFGRSMSSLQNSRD-HANEELDELKRKYDASLKELAQLKEQGLLNRERDA 2783
Query: 1335 MMSEAALNGNGDDLNN 1350
++SE A + N + N+
Sbjct: 2784 LLSETAFSMNSTEENS 2799
Score = 173 bits (438), Expect = 1e-42
Identities = 252/1195 (21%), Positives = 509/1195 (42%), Gaps = 190/1195 (15%)
Query: 311 PSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAE 370
PS S +S +SV+ ++ + K+S TT+ E+ +++ + +
Sbjct: 1289 PSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINK 1348
Query: 371 RDLERAEVAKATSHVGEIEQELALARDGHDQ-------HVLELEAKMDQLRTMVEAADRE 423
+ LE E K SH E+ E + Q H+ EL+ K+D+L+ ++ + +
Sbjct: 1349 QGLE-IESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407
Query: 424 KVELLNQLEEEKRKVEDLQFRV-EEESITKG---DLETQTKLEHARIKELEQSLLFEKTK 479
L QL E++ + +Q + E+E + K LE Q K RIK+L+ L K K
Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQK 1467
Query: 480 ADKLQRELE-------DTRVATVSEKSRIME---LEKDLALRVQEVAELRRRL------- 522
+++ E + A +S K + E L+++L+L + L + L
Sbjct: 1468 PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQV 1527
Query: 523 -------------------ESNKPAGDVDMSL----SLLQEISSLQEKLEVTRTDHQR-- 557
E +K ++D SL SL SL+ LE D ++
Sbjct: 1528 SAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLV 1587
Query: 558 -EITSLKEHFGAR----EETH---QKEIKALYTATEKLSKENESLKSKLEHANKENSDVI 609
EI SLK A +E H QKE + L + E +S E E ++ +E +E ++
Sbjct: 1588 KEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELY 1647
Query: 610 ALWKS------KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI 663
+S + E + +Q MEE+K K ++ + EL+ + +++R +
Sbjct: 1648 GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAG 1707
Query: 664 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
+ + ++ +++A +++ +L +V E E + +S + + +D E++D ++
Sbjct: 1708 DTAKECMETLLSSNA----SMKEELERVKMEYETLSKKFQSLMSE-KDSLSEEVQDLKHQ 1762
Query: 724 LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD-ALRKASSEG------- 775
++ K LE + K + QT V + T + E+ L + R SE
Sbjct: 1763 IEGNVSKQANLEATE-KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821
Query: 776 ----------KSEMKKLRQQLEAAEKQI--------------KHLEIEKNAESSKASSIT 811
E+ QQ++ +++I + LE EKN S+ S+
Sbjct: 1822 NPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKD 1881
Query: 812 RELQGRELKLTNL-------QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ 864
EL+ + ++T + QE LS V+++KET E+E L+E+ E +
Sbjct: 1882 GELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYC 1941
Query: 865 ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE--I 922
+ V K E +L S+++ L++ ++++E E ++QL+K K K+E++I + +
Sbjct: 1942 QDVTDAQIKNE---LLESEMKNLKKCVSELE-------EEKQQLVKEKTKVESEIRKEYL 1991
Query: 923 MKMSG-----DNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 977
K+ G N S ++ + L+ K+++V++LQ + E S L+++++ + +
Sbjct: 1992 EKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTE 2051
Query: 978 SQQEAAKKHE------EEKKELERKLSDLEKKMETSHNQC-----------QELKARYER 1020
SQ++ E E +K+ + +L+ + ++ + ++ +EL++ E
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111
Query: 1021 ATSETKTKHEEILQNLQ-------KTLLDTEDKLKGAREENSGLLQELEELRKQADKA-K 1072
S+ K K E++ + L+ K + ++KL R E L + + E++ +K K
Sbjct: 2112 VKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDK 2171
Query: 1073 AAQTAEDAMQIMEQMTKEKTETLASLED--------TKQTNAKLQNELDT------LKEN 1118
Q ++ + T++++SL+D K+ K + + + LKE+
Sbjct: 2172 EVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKED 2231
Query: 1119 NLK----NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQL-SALQEENVKLAE 1173
N + +++ E L + ++E ++ E+ Q Q Q++ LQ EN +L
Sbjct: 2232 NCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLS 2291
Query: 1174 ELGRSRDEVTSHQ----KLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSA 1229
+L +R S Q KLE E L +QL ++ S ++ E+K +L+ I A
Sbjct: 2292 QLEETRHLYHSSQNELAKLESELKSLKDQLTDL----SNSLEKCKEQKGNLEGIIRQQEA 2347
Query: 1230 LLTEKDAELEKLR------NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQL 1283
+ E+L E+T E + K ++ L + +++ + L Q
Sbjct: 2348 DIQNSKFSYEQLETDLQASRELTSRLHEEINMKE-QKIISLLSGKEEAIQVAIAELRQQH 2406
Query: 1284 KENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQR-KNQDLKMKVEMMS 1337
+ ++L + + + E + +D N ++ L+ K ++++ K ++ S
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDS 2461
Score = 159 bits (401), Expect = 2e-38
Identities = 234/1147 (20%), Positives = 491/1147 (42%), Gaps = 168/1147 (14%)
Query: 303 TSASLKRSPSASSLSSMSSVASSVSSRPS-----RTGLLTETSSRYARKISGTTA----- 352
T A +K S + ++ S + +T + +E Y KI G
Sbjct: 1945 TDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK 2004
Query: 353 -----LQEALKEKQQHIEQLLAERDLERAE--------VAKATSHVG-EIEQELALARDG 398
LQE LKEKQQ ++QL ++D R + KA V E +++L + ++
Sbjct: 2005 SHAKELQELLKEKQQEVKQL--QKDCIRYQEKISALERTVKALEFVQTESQKDLEITKEN 2062
Query: 399 HDQ---HVLELEAKMDQLRTMVEAADREKVELLN---QLEEE------------KRKVED 440
Q H + +A++ + +++ E +L +L++E K+K ED
Sbjct: 2063 LAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDED 2122
Query: 441 LQFRVE--EESITKGDLETQTKLEHAR---------IKELEQSLLFEKTKADKLQRELED 489
L+ R+E EE K Q KL+ R I E++ +L + + +LQ L+
Sbjct: 2123 LERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDS 2182
Query: 490 TRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLS---------LLQE 540
T + + L+ D + E + R+ + + ++ L L++
Sbjct: 2183 TVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ 2242
Query: 541 ISSLQE--KLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL 598
+S E K+ ++R +H ++I K Q E++ + L EN+ L S+L
Sbjct: 2243 MSIHMEELKINISRLEHDKQIWESKA---------QTEVQLQQKVCDTLQGENKELLSQL 2293
Query: 599 E---HANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK---GLGTETAEFAELKTQI 652
E H + + +A KLE+ + S + + +L S K G + + I
Sbjct: 2294 EETRHLYHSSQNELA----KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADI 2349
Query: 653 EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ 712
+ + Y+ +LQ ++ H +E+ K++ ++ KE +++ ++L + D+
Sbjct: 2350 QNSKFSYEQLETDLQASRELTSRLH-EEINMKEQKIISLLSGKEEAIQVAIAELRQQHDK 2408
Query: 713 HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 772
+ E+E+ L++ +E I ++E + ++ ++++ + K ++ LD+ K+
Sbjct: 2409 EIKELENLLSQEEEENIVLEEEN--KKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466
Query: 773 SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS 832
S +++ ++ + E++ + +EK+ +A++ +L+ ++ L+ ++ +++
Sbjct: 2467 SSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKE---EIRGLRSHMDDLN 2523
Query: 833 QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLA 892
L+ EL +E + S Q+ + E +L Q +E N + EKL+E+
Sbjct: 2524 SENAKLDAELIQYREDLNQVITIKDSQQKQLLEV--QLQQNKELENKYAKLEEKLKESEE 2581
Query: 893 ---DMEAKFREKDEREEQLIKAKEKLENDIAEIMKM--SGDNSSQLTKMNDELRLKERDV 947
D+ F E ++ L K E L+ I+++ + + L + +L++KE +V
Sbjct: 2582 ANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEV 2641
Query: 948 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETS 1007
L + + QK I ++ + Q+EAAKK E + +L+++L L
Sbjct: 2642 HRLSALFSSS-------QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIM 2694
Query: 1008 HNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RK 1066
N ET+T E + + L + L++ E KL +EN GL +++ R
Sbjct: 2695 RN--------------ETETAEERVAE-LARDLVEMEQKLLMVTKENKGLTAQIQSFGRS 2739
Query: 1067 QADKAKAAQTAEDAMQIMEQMTKEKTETLASLED----TKQTNAKLQN---ELDTLKENN 1119
+ + A + + +++ + LA L++ ++ +A L +++ +EN+
Sbjct: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENS 2799
Query: 1120 LKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSR 1179
L ++E+LN+ L +++++ ++E S+ +++LQ E L EL + R
Sbjct: 2800 LSHLEKLNQQ---LLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR 2856
Query: 1180 DEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1239
K EE K+R + + E SL+K++ S+L ++D L+
Sbjct: 2857 -------KSEEG-----------KQRSAAQPSTSPAEVQSLKKAM---SSLQNDRDRLLK 2895
Query: 1240 KLRNEVTVLRGENASAKSLHSVVQTLE--SDKVKL------ELKVKNLELQLKENKRQLS 1291
+L+N N LH + L+ DK K EL+ +NL Q + ++ ++
Sbjct: 2896 ELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRME 2955
Query: 1292 SSSGNTDTQADEDE-----RAQESQIDFLNSVIVDLQ---RKNQDLKMKVEMMSEAALNG 1343
SS + +++ ++ Q+ L ++I +L+ + Q LK++ + + +
Sbjct: 2956 KSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSA 3015
Query: 1344 NGDDLNN 1350
+ D N
Sbjct: 3016 SPDGSQN 3022
Score = 144 bits (363), Expect = 6e-34
Identities = 255/1179 (21%), Positives = 482/1179 (40%), Gaps = 177/1179 (15%)
Query: 317 SSMSSVASSVSSR-PSRTGLLTETSSRYARKISGTTALQEALKEKQQHI---EQLLAE-- 370
S S++ S+ S+ ++ + E + R S L +AL +K+ I +QLL E
Sbjct: 827 SEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKK 886
Query: 371 RDLERAE--VAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELL 428
RD+E + + + V EI + ++ L ++ L+ + R +
Sbjct: 887 RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKK 946
Query: 429 NQLEEEKRKVEDLQFRVEEES----ITKGDLETQTKL----EHARIKELEQSLLFEKTKA 480
Q+EE+ L+ +E S I+K +L+ + L R ++L+ +L+ K
Sbjct: 947 EQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELL 1006
Query: 481 DKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 540
++ R LE+ E + + L + V+E E + E + ++ + L Q
Sbjct: 1007 QRVSR-LEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT 1065
Query: 541 ISSLQEKLEVTRTDHQREITSLKEHFGA----REETHQKEIKALYTATEKLSKENESLKS 596
IS + +L+ R D + ++ + +E F A +T Q + + ++S EN+++
Sbjct: 1066 ISEKEVELQHIRKDLEEKLAA-EEQFQALVKQMNQTLQDKTNQIDLLQAEIS-ENQAIIQ 1123
Query: 597 KLEHANKENSD--VIAL-----------------WKSKLETAIASHQQAMEELKVSFSKG 637
KL +N + SD +AL WK +LE I + ++ E+L+ +
Sbjct: 1124 KLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEA 1183
Query: 638 LGTETA--------------EFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEA 683
L + A E + K +++ + + + +N D R + E+
Sbjct: 1184 LTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRES 1243
Query: 684 LRAKLMKVIKEKE-NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCN 742
+ KL +++ +S + L KA +QH + N + ++ LQ +
Sbjct: 1244 IDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTS 1303
Query: 743 EQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK-----SEMKKLRQQLEAAEKQIKHLE 797
+ +QLK E + ++L+ L+ +S+ + E+ +L++Q+ +I+ L+
Sbjct: 1304 -----VAQIKAQLKEIEAEKVELE-LKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLK 1357
Query: 798 IEKNAESSKASSITRELQGRELK------LTNLQENLSEVSQVKETLEKELQILKEKFAE 851
+ A S+ ++L+ +L+ L LQ L E+ ++ E+++ L + +E
Sbjct: 1358 TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
Query: 852 ASEEAVSVQRSM---QETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFRE--KDERE 905
+Q + ++ + LH Q E Q +++L+ L +M+ K E ++ R
Sbjct: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
Query: 906 EQ---------LIKAKEKLEND-------------IAEIMKMSGDNSSQLTKMNDE---- 939
+Q LI KE L+ + I + K D SQ++ N E
Sbjct: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Query: 940 -----LRLKERD-------------------VEELQLKLTKANENASFLQKSIEDMTVKA 975
L +ERD E L+L L E+ L K IE +
Sbjct: 1538 LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
Query: 976 EQSQQEAAKKHEEEKKELERKLSDLEK----------KMETSHNQCQELKARYERATSET 1025
E +KH+E +KE E L E +E + QEL + R+T
Sbjct: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKL-RSTEAN 1656
Query: 1026 KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL--RKQADKAKAAQTAEDAMQI 1083
K + E+ LQ ++ + + ++K++ + + ELEE R +A+ A TA++ M+
Sbjct: 1657 KKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMET 1716
Query: 1084 MEQMTKEKTETLASLEDTKQTNAK----LQNELDTLKE--NNLKNVEELNKSKELLTVEN 1137
+ E L ++ +T +K L +E D+L E +LK+ E N SK+
Sbjct: 1717 LLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEAT 1776
Query: 1138 QKMEEFRKEIETLKQAAAQKSQQLSALQ-------EENVKLAEELG-------RSRDEVT 1183
+K + E Q+ ++++ +L E+V A+ S DE+
Sbjct: 1777 EKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEIN 1836
Query: 1184 SHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRN 1243
++ + ++ L E K++ +F + + EK +L IS KD EL+ L+
Sbjct: 1837 NYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS-------TKDGELKMLQE 1889
Query: 1244 EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGN---TDTQ 1300
EVT + N + S V L K E + +LE +L +L+ S GN T
Sbjct: 1890 EVTKMNLLNQQIQEELSRVTKL---KETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTD 1946
Query: 1301 ADEDERAQESQIDFLNSVIVDLQRKNQDL-KMKVEMMSE 1338
A ES++ L + +L+ + Q L K K ++ SE
Sbjct: 1947 AQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESE 1985
Score = 139 bits (349), Expect = 3e-32
Identities = 241/1154 (20%), Positives = 479/1154 (41%), Gaps = 196/1154 (16%)
Query: 351 TALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD---QHVLELE 407
T +Q+ L+ Q+ +E+ E + RA+V V ++QEL A + Q + ++E
Sbjct: 248 TEMQQKLRVLQRKLEEH-EESLVGRAQV------VDLLQQELTAAEQRNQILSQQLQQME 300
Query: 408 AKMDQLRTMVEAADREKVELLNQLE----EEKRKVEDLQFRVE---EESITKGDLETQTK 460
A+ + LR VE E LL ++E E K +LQ + E+ G + + +
Sbjct: 301 AEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELE 360
Query: 461 LEHARIKELEQSLLFEKTK----ADKLQRELEDTRVATVSEKSRIMELEKDLALR-VQEV 515
++ +++ ++ + EKT K +EL+ A + S++++ + + A++ Q +
Sbjct: 361 SRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTI 420
Query: 516 AELRRRLES-NKPAGDVDMSLSLLQEISSLQEKL-----EVTRTDHQREITSLKEHFGAR 569
+L +L+ +K L L Q ++ Q E T+ + I SL++
Sbjct: 421 QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRV-VE 479
Query: 570 EETHQKEIKALYTATEKLSKENESLKSKLE---------HANKENSDV--IALWKSKLET 618
E + + E+L ENE L S++ A++E S++ + + + +
Sbjct: 480 LENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSS 539
Query: 619 AIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE-IENLQNQQDSERAAH 677
A S Q +E K L E E + +I ++L Q + E ++ ++
Sbjct: 540 AEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMK 599
Query: 678 AKEMEALRAKLMKVIKE-----------KENSLEAIRSKLDKAEDQ-------------- 712
E E + MKV E +E+SL A+ + E Q
Sbjct: 600 QMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGV 659
Query: 713 --------------------------------HLVEMEDTLNKLQEA-----EIKVKELE 735
++E+E +K QE + K KE+
Sbjct: 660 ELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEIS 719
Query: 736 VLQAKCNEQTKVIDNFTSQLKA-TEEKLLDLDALRKAS--SEGKSEMKKLRQQLEAAEKQ 792
L E K DN +S A +EE+ L +++ S +E ++++K+L L AE+Q
Sbjct: 720 NLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ 779
Query: 793 IKHLEIEK-----NAESSKASSITRELQGRELKLTNLQENL-------SEVSQVKETLEK 840
+ L+ E N + + S++ E + +++K+ LQ L SE S + +L+
Sbjct: 780 -RRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQS 838
Query: 841 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 900
+LQ + + E +E + ++E L QKE + + + L E D+E +
Sbjct: 839 QLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMD---QLLLEKKRDVETLQQT 895
Query: 901 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
+E+++Q+ + + + ++ + ++ + ++L L R E + ++ + NE
Sbjct: 896 IEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEV 955
Query: 961 ASFLQKSIEDMTVKAEQSQQE------AAKKHEEE-----------KKELERKLSDLEKK 1003
+S L+++ ++M+ + S++E KK E+ +KEL +++S LE++
Sbjct: 956 SSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEE 1015
Query: 1004 M--------------ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1049
+ ET + +E K E + +K +EI L++T+ + E +L+
Sbjct: 1016 LANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQH 1075
Query: 1050 AR---EENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED--TKQT 1104
R EE ++ + L KQ + QT +D ++ + E +E A ++ T T
Sbjct: 1076 IRKDLEEKLAAEEQFQALVKQMN-----QTLQDKTNQIDLLQAEISENQAIIQKLITSNT 1130
Query: 1105 NAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIE----TLKQAAAQKSQQ 1160
+A + + +KE + + S+ +K+ KE E L++A +
Sbjct: 1131 DASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAI 1190
Query: 1161 LSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQL------LEMKKRES---KFIK 1211
L QE+ L EEL + +D+ Q+ +E+S N + L+++ RES K
Sbjct: 1191 LKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPS 1250
Query: 1212 DADEEKASLQKSISITSALLTEKDAELEKLRN-----------EVTVLRGENASAKSLHS 1260
+E S + TE+ L + + + L+G S + +
Sbjct: 1251 TDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQG-GTSVAQIKA 1309
Query: 1261 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV 1320
++ +E++KV+LELKV + +L + ++ Q E Q +I+ L +V
Sbjct: 1310 QLKEIEAEKVELELKVSSTTSELTKKSEEV--------FQLQEQINKQGLEIESLKTVSH 1361
Query: 1321 DLQRKNQDLKMKVE 1334
+ + + L+ K+E
Sbjct: 1362 EAEVHAESLQQKLE 1375
Score = 133 bits (334), Expect = 1e-30
Identities = 220/1024 (21%), Positives = 432/1024 (42%), Gaps = 119/1024 (11%)
Query: 355 EALKEKQQHIEQLLA--ERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
E +K K Q E+L++ + L +A+ + E+E+ + + Q + E E +
Sbjct: 147 EKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMK-----QQLQEKEEFIST 201
Query: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEES----ITKGDLET--QTKLE--HA 464
L+ + E+ Q+ EK + Q R+ E+ +T+ D+ET Q KL
Sbjct: 202 LQAQLSQTQAEQAA--QQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQR 259
Query: 465 RIKELEQSLLFEKTKADKLQREL--EDTRVATVSEKSRIMELEKDLALRVQEVAELRRRL 522
+++E E+SL+ D LQ+EL + R +S++ + ME E + E ++
Sbjct: 260 KLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKI 319
Query: 523 ESNKPAGDV-DMSLS---LLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK 578
K +V + LS L +E+ L E+ E + L+ + A E+ H+ E++
Sbjct: 320 LLEKMELEVAERKLSFHNLQEEMHHLLEQFE----QAGQAQAELESRYSALEQKHKAEME 375
Query: 579 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ--QAMEELKVSFSK 636
+ L K + L+S + +NS ++ + K E A+ S Q Q +E+ SK
Sbjct: 376 EKTSHILSLQKTGQELQSACDALKDQNSKLL---QDKNEQAVQSAQTIQQLEDQLQQKSK 432
Query: 637 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 696
E+ + ++ L QHE + + D E A L K + E E
Sbjct: 433 ----------EISQFLNRLPLQ-QHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELE 481
Query: 697 NS-----LEAIRSKLDKAEDQHL---VEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI 748
N L +I + KAE++ L + + + N+ EA+ +V E+ ++ +
Sbjct: 482 NEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE 541
Query: 749 DNFTSQLKAT-EEKLLDLDALRKASSEGKSEMKKLRQQLEAA-----------EKQIKHL 796
++ L+ T +K +L L E + E+ L+ QL+ +K++K +
Sbjct: 542 ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQM 601
Query: 797 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEA 856
E E A + E G++ L +E+ S + KE E Q + ++
Sbjct: 602 EGEGIAPIK--MKVFLEDTGQDFPLMPNEES-SLPAVEKEQASTEHQSRTSEEISLNDAG 658
Query: 857 VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI--KAKE- 913
V ++ + Q+ L + +LE+L+ + ++E F + E E+ + KAKE
Sbjct: 659 VELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEI 718
Query: 914 -KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMT 972
L I E K + +NSS T +++E V+EL + +T+ L+ ++ +
Sbjct: 719 SNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSM-VTELRAQVKQLEMNLAE-A 776
Query: 973 VKAEQSQQEAAKKHE----EEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTK 1028
+ + E+ H+ E+ L + + K+E N+ +++ ++ ++ ++
Sbjct: 777 ERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836
Query: 1029 HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEE------------LRKQADKAKAAQT 1076
+ LQN + +L+ ++++ + L Q L + L K+ D QT
Sbjct: 837 QSQ-LQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT 895
Query: 1077 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE--NNLKNVEELNKSK---- 1130
E+ Q + +++ TE + L + K L E+ TLKE N L EE K +
Sbjct: 896 IEEKDQQVTEISFSMTEKMVQLNEEK---FSLGVEIKTLKEQLNLLSRAEEAKKEQVEED 952
Query: 1131 ------------ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRS 1178
E+ EE + E + LK+ Q+ ++L A +L + + R
Sbjct: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRL 1012
Query: 1179 RDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE--KASLQKSISITSALLTEKDA 1236
+E+ ++ K E ++ + ++ + E K K+ E+ + Q+ ++EK+
Sbjct: 1013 EEEL-ANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEV 1071
Query: 1237 ELEKLRNEV-TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSS-SS 1294
EL+ +R ++ L E + + QTL+ +++L L+ ++ EN+ + +
Sbjct: 1072 ELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDL----LQAEISENQAIIQKLIT 1127
Query: 1295 GNTD 1298
NTD
Sbjct: 1128 SNTD 1131
Score = 123 bits (308), Expect = 1e-27
Identities = 218/1053 (20%), Positives = 429/1053 (40%), Gaps = 209/1053 (19%)
Query: 314 SSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDL 373
S+++ +++ S+SS + + + ++ RK S +A++ K++ I +
Sbjct: 2182 STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFS------DAIQSKEEEIRLKEDNCSV 2235
Query: 374 ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMD-QLRTMV-EAADREKVELLNQL 431
+ ++ + + H+ E++ + ++R HD+ + E +A+ + QL+ V + E ELL+QL
Sbjct: 2236 LKDQLRQMSIHMEELK--INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQL 2293
Query: 432 EEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTR 491
EE + Q + + LE++ K ++ +L SL K + L+ +
Sbjct: 2294 EETRHLYHSSQNELAK-------LESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE 2346
Query: 492 VATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVT 551
+ K +LE DL Q EL RL + + L + ++Q +
Sbjct: 2347 ADIQNSKFSYEQLETDL----QASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
Query: 552 RTDHQREITSLKEHFGAREETH---QKEIKALYTATEKL-------SKENESLKSKLEHA 601
R H +EI L+ EE + ++E K T +L KEN K++L+
Sbjct: 2403 RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSF 2462
Query: 602 NKENSDV--------------------IALWKSKL-ETAIASHQQAMEELKVSFSKGLGT 640
K S + I L K +L + A A + + EE++ +
Sbjct: 2463 VKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIR-GLRSHMDD 2521
Query: 641 ETAEFAELKTQIEKMRLDYQHEI---ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN 697
+E A+L ++ + R D I ++ Q Q + KE+E AKL + +KE E
Sbjct: 2522 LNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEE 2581
Query: 698 SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757
+ E +R + ++ E +D +++ ++ + +L Q ++ + + +QLK
Sbjct: 2582 ANEDLRRSFNALQE----EKQDLSKEIESLKVSISQL-TRQVTALQEEGTLGLYHAQLKV 2636
Query: 758 TEEKLLDLDALRKASSEGKSEMKK---------------------------------LRQ 784
EE++ L AL +S + +E+++ +R
Sbjct: 2637 KEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRN 2696
Query: 785 QLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQI 844
+ E AE+++ L + K +T+E +G ++ + ++S + ++ +EL
Sbjct: 2697 ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDE 2756
Query: 845 LKEKF---------------------AEASEEAVSVQRSMQETVNKLHQ-------KEEQ 876
LK K+ A SE A S+ + + +++ L + K+EQ
Sbjct: 2757 LKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQ 2816
Query: 877 FNMLSSDLEKL-----------------RENLADMEAKFREKDEREEQ------------ 907
LSS LE R++L + KFR+ +E +++
Sbjct: 2817 LLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEV 2876
Query: 908 --LIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 965
L KA L+ND ++K + Q ++N E+ ++ L+ +L + + Q
Sbjct: 2877 QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT----ELHPLKAQLQEYQDKTKAFQ 2932
Query: 966 KSIEDMT------------VKAEQSQQEAAKKHEEEK-----KELERKLSDLE---KKME 1005
E++ ++ E+S E ++ +E+ + +++LS L+ +++
Sbjct: 2933 IMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELR 2992
Query: 1006 TSHNQCQELKARYERATSETKTKHEEILQNL--QKTLLDTE--DKLKGAREENSGLLQEL 1061
+S +Q Q LK +Y+R S + + QNL + LL T+ D LK +
Sbjct: 2993 SSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQ--------- 3043
Query: 1062 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1121
+ELR Q + +Q E+ + Q+ +T SL + +Q L N L+ K
Sbjct: 3044 KELRIQQLNSNFSQLLEEKNTLSIQL----CDTSQSLRENQQHYGDLLNHCAVLE----K 3095
Query: 1122 NVEELNKSKELLTV----ENQKMEEFRK----EIETLKQAAAQKSQQLSALQEENVKLAE 1173
V+EL + V +K RK E+ +Q+ ++ QQL ++E +L +
Sbjct: 3096 QVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRK 3155
Query: 1174 ELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRE 1206
L RD+ + E SV Q+ ++ E
Sbjct: 3156 LLEEERDQRVA---AENALSVAEEQIRRLEHSE 3185
Score = 102 bits (254), Expect = 3e-21
Identities = 176/870 (20%), Positives = 367/870 (42%), Gaps = 136/870 (15%)
Query: 571 ETHQKEIKALYTATEKLSKENESLKSKLEHANK---ENSDVIALWKSKLETAIASHQQAM 627
E HQ+ T+ E ++ +L +A + E D+I +L+ + Q+
Sbjct: 33 ELHQESDMEFNNTTQ------EDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEER 86
Query: 628 EELKVSFSKGLGTETAEFAELKTQIEKMR------LDYQHEIENLQNQQDSERAAHAKEM 681
+ K A+ L IE+M+ L + + E ++ D E+
Sbjct: 87 KAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEI 146
Query: 682 EALRAKLMKVIKEKENSLEAIRSKLDKAED----QHLVEMEDTLNKLQEAEIKVKELEVL 737
E ++ KL +EKE + ++++L +A+ Q EME+ + Q+ + K + + L
Sbjct: 147 EKIKHKL----QEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202
Query: 738 QAKCNE-------QTKVIDN---FTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 787
QA+ ++ Q V + F +Q++ E++LL L +E + +++ L+++LE
Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLE 262
Query: 788 AAEKQ-------IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 840
E+ + L+ E A + ++++LQ E + L+ + ET +
Sbjct: 263 EHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTV-------ETERE 315
Query: 841 ELQILKEKFA-EASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFR 899
E +IL EK E +E +S +E +H EQF +L + +E K +
Sbjct: 316 ESKILLEKMELEVAERKLSFHNLQEE----MHHLLEQFEQAGQAQAELESRYSALEQKHK 371
Query: 900 EKDEREEQLIKAKEKLENDIAEIM-KMSGDNSSQLTKMNDELRLKERDVEELQLKL-TKA 957
+ E + I + +K ++ + NS L N++ + +++L+ +L K+
Sbjct: 372 AEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKS 431
Query: 958 NENASFL------QKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKK---METSH 1008
E + FL Q T + + EE L++++ +LE + + S
Sbjct: 432 KEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSS 491
Query: 1009 NQCQELKARYERATS-----ETKTKHEEILQNLQK-TLLDTEDKLKGAREEN-------- 1054
+ +ELKA E+ +S E + + E + + + +++D +K + EE+
Sbjct: 492 IELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENT 551
Query: 1055 --------SGLLQELEELRKQAD------KAKAAQTAEDAMQIMEQMTKEKTETLAS--- 1097
S LL E++E +++ + K A+ A+ + ++M + + E +A
Sbjct: 552 FSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKM 611
Query: 1098 ---LEDTKQTNAKLQNELDTLK--ENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1152
LEDT Q + NE +L E + E +++ E +++ + +E LK
Sbjct: 612 KVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE--------LKS 663
Query: 1153 AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQ-KLEEERSVLNNQLLEMKKRESKFIK 1211
+ LSA+ + +EL R + ++ + + + + L E K S +
Sbjct: 664 TKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQ 723
Query: 1212 DADEEKASLQKSISITSALLTEKDAELEKLR--NEVTVLRGE-----------------N 1252
+E K + + S +AL E+D L +++ + VT LR + +
Sbjct: 724 LIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLD 783
Query: 1253 ASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKR---QLSSSSGNTDTQADEDERAQE 1309
+++ H + T + + +E K K++++++ +N+ QL S +T R+ +
Sbjct: 784 YESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLI------RSLQ 837
Query: 1310 SQIDFLNSVIVDLQRKNQDLKMKVEMMSEA 1339
SQ+ S +++ + + + KVE +S+A
Sbjct: 838 SQLQNKESEVLEGAERVRHISSKVEELSQA 867
>gi|18496983 CAP-GLY domain containing linker protein 3 [Homo
sapiens]
Length = 547
Score = 173 bits (439), Expect = 9e-43
Identities = 100/256 (39%), Positives = 142/256 (55%), Gaps = 42/256 (16%)
Query: 59 RVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIF 118
R+G+RV ++G K G ++F G T+FA GQW G+ LDEP GKNDGSV GVRYF C P +G+F
Sbjct: 295 RLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLF 354
Query: 119 TRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTP----SNIPQKPSQP 174
SK+++ V A S V+S+P TP S + K +
Sbjct: 355 ASVSKISKAVDA----------------------PPSSVTSTPRTPRMDFSRVTGK-GRR 391
Query: 175 AAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGET 234
K TP +S S+ +L + K ++GD+VLV G K G+VRF G+T
Sbjct: 392 EHKGKKKTP--------SSPSLGSLQQRDGAK-----AEVGDQVLVAGQKQGIVRFYGKT 438
Query: 235 DFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKAN 294
DFA G W G+ELD+P GK+DG+V G RYF C P++G+FAP ++ +IG +T + +
Sbjct: 439 DFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIG--GSTDSPGDSV 496
Query: 295 AVRRVMATTSASLKRS 310
++V T KR+
Sbjct: 497 GAKKVHQVTMTQPKRT 512
Score = 100 bits (248), Expect = 1e-20
Identities = 59/146 (40%), Positives = 80/146 (54%), Gaps = 9/146 (6%)
Query: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
A P L K + N+ G++ L++GDRVL+ G K G +RF G T+FA G+
Sbjct: 265 AVPLSCALPKVTLPNYDNVP--GNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQ 322
Query: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI--GFPSTTPAKAKANAVRR 298
W GVELDEP GKNDG+V G RYF C PK GLFA V K++K PS+ + + +
Sbjct: 323 WVGVELDEPEGKNDGSVGGVRYFICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDF 382
Query: 299 VMATTSA-----SLKRSPSASSLSSM 319
T K++PS+ SL S+
Sbjct: 383 SRVTGKGRREHKGKKKTPSSPSLGSL 408
>gi|31982881 CAP-GLY domain containing linker protein family, member
4 [Homo sapiens]
Length = 705
Score = 173 bits (438), Expect = 1e-42
Identities = 117/337 (34%), Positives = 174/337 (51%), Gaps = 63/337 (18%)
Query: 59 RVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIF 118
++G+RV + G K G ++F G T+FA GQWAGI LDEP GKN+GSV V+YF+C P GIF
Sbjct: 284 KLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIF 343
Query: 119 TRPSKLTRKVQAEDEANGLQTTPASRATSPLCTS-----------------TASMVSSSP 161
SK+++ A+ + TP+++A PL S T+ S+S
Sbjct: 344 APLSKISK---AKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASE 400
Query: 162 STPSNIPQKPSQPAAKE-----------------------PSATPPISNLTKTASES--I 196
ST S P + + ++ P IS+ KT S+S +
Sbjct: 401 STLSLPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSL 460
Query: 197 SNLSEAG---------SIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELD 247
S+ + AG + + E EL++G+RVLV G + G +RF G T+FA G W G+EL+
Sbjct: 461 SSRASAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELE 520
Query: 248 EPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKAN-------AVRRVM 300
+P GKNDG+V G +YF C P+YG+FAP +V ++ T ++ +N RR
Sbjct: 521 KPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSF 580
Query: 301 ATTSASLKRSPSASSLSSMSSVA--SSVSSRPSRTGL 335
+TTSAS ++ + + S S A S SS P+ G+
Sbjct: 581 STTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGI 617
Score = 143 bits (360), Expect = 1e-33
Identities = 88/241 (36%), Positives = 122/241 (50%), Gaps = 17/241 (7%)
Query: 43 SSTPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGS 102
SS S+ + R+GERV V G + G I+F G T FAPG W GI L++P GKNDGS
Sbjct: 470 SSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGS 529
Query: 103 VAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPS 162
V GV+YF C P GIF PS++ R + D + + + + + S ++ +SS
Sbjct: 530 VGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASS-- 587
Query: 163 TPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLV-G 221
KE + S S S+ AG I +G +L G +VL+
Sbjct: 588 -------------QKEINRRNAFSKSKAALRRSWSSTPTAGGI-EGSVKLHEGSQVLLTS 633
Query: 222 GTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI 281
+ G VR++G TDFA G W G+EL GKNDG+V RYF C+P +G+ +VT
Sbjct: 634 SNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVTYR 693
Query: 282 G 282
G
Sbjct: 694 G 694
Score = 101 bits (252), Expect = 4e-21
Identities = 58/169 (34%), Positives = 84/169 (49%), Gaps = 7/169 (4%)
Query: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
A P N++K + +++ G LK+GDRV++ G K G +RF G T+FA G+
Sbjct: 254 AVPLSCNISKAMLPNYDHVT--GKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQ 311
Query: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI-----GFPSTTPAKAKANA 295
W G+ELDEP GKN+G+V +YF+C PKYG+FAP+ K++K T KA
Sbjct: 312 WAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKGRRKNITHTPSTKAAVPL 371
Query: 296 VRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYA 344
+R + + + S S + S S P L T T A
Sbjct: 372 IRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTVTEKDVA 420
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 172 bits (436), Expect = 2e-42
Identities = 247/1208 (20%), Positives = 500/1208 (41%), Gaps = 215/1208 (17%)
Query: 289 AKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKIS 348
A K +A+ +A L + + S + ++ +R L + + R+
Sbjct: 597 AAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRR-- 654
Query: 349 GTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA--LARDGHDQHVLEL 406
EAL EK H+E L + + AE+ + E ++E+ L+ H Q
Sbjct: 655 ------EALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQ----- 703
Query: 407 EAKMDQLRTMVEAADREKVELLNQLEEEKRKVED---LQFRVEEESITKGDLETQTKLEH 463
EA QL + + A R++ L ++E++ V + L+ R++ + DL Q +
Sbjct: 704 EAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQ-GL 762
Query: 464 ARIKELEQSLLFEKTKADKLQRELE---DTRVATVSEKSRIMELEKDLALRVQEVAELRR 520
+ KEL +S LFE + + + + + ++ TV++ +++ EV L+
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ---------GEVRCLKL 813
Query: 521 RLESNKPAGDVDMSLSLLQEISSLQE---KLEVTRTDHQREITSLKEHFGAREETHQKEI 577
L++ + + + + Q + QE LE + H++E+ L+E + HQ+E
Sbjct: 814 ELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQE- 872
Query: 578 KALYTATEKLSKENESLKSKLEHANKENSDVIALW---KSKLETAIASHQQAMEELKVSF 634
L A E L +E L+ +L+ E + A +++ E+A+ Q E+ +VS
Sbjct: 873 --LAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL 930
Query: 635 SKGLGTETAEFAELKTQIEKMRLDY--------------QHEIENLQNQQDSERAAHAKE 680
+ L E A+ Q+E++R D Q +++ Q + H +
Sbjct: 931 LETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDD 990
Query: 681 MEALRAKLMKVIKEK---ENSLEAIRSKLDKAED-QHLVEME--DTLNKLQEAEIKVKEL 734
+ AL+ + ++++K + +E ++S+L +D Q LVE E + L + QE KEL
Sbjct: 991 LAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKEL 1050
Query: 735 EVLQAKCNEQTKVIDNFTSQLKATEEKLL-----------DLDALRKASSEGKSEMKKLR 783
E +A + T L E++LL +L ALR+ E + E K+L
Sbjct: 1051 EREKA----------SLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELS 1100
Query: 784 QQLEAAEKQIKHLEIEKNAESSK------ASSITRE-----LQGRELKLTNLQENLSEVS 832
Q+E +++K E + A+ ++ AS IT + L +E K LQ L
Sbjct: 1101 AQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTE 1160
Query: 833 QVKETLEKELQILKEKFAEASEEAVSVQRSMQETV------------------------- 867
E L E Q + A+A + S+ ++Q+ +
Sbjct: 1161 SQLEALAAEQQPGNQ--AQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEP 1218
Query: 868 ---------------------------NKLHQK----EEQFNMLSSDLEKLRENLADMEA 896
+KLHQ ++ ++L ++KL E L D EA
Sbjct: 1219 DQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEA 1278
Query: 897 KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS---QLTKMNDELRLKERDVEELQLK 953
EK + +L + +L + E K G +S +L ++++ + + + +L+
Sbjct: 1279 ---EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335
Query: 954 LTKANENASFLQKSIEDMTVKAE---------QSQQEAAKKHEEEKKELERKLSDLEKKM 1004
+A LQ + E++T + E ++Q AA EE+ + L +++
Sbjct: 1336 RMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEV 1395
Query: 1005 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1064
E+ + Q L+ + E ++ K E L L +TL + E++++ R G +QELE+
Sbjct: 1396 ESERERAQALQEQGELKVAQGKALQEN-LALLTQTLAEREEEVETLR----GQIQELEKQ 1450
Query: 1065 RKQADKA-------------------KAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTN 1105
R+ A + Q E ++E + E L ++
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI 1510
Query: 1106 AKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQ 1165
+L+ + +T + + EL K +++ + ++++ +K++ TL+ A + + ++
Sbjct: 1511 RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570
Query: 1166 EENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSIS 1225
+ KL +EL R E +R L + L++++R S+ ++ + L+ +
Sbjct: 1571 CQQ-KLIKELEGQR---------ETQRVALTHLTLDLEER-SQELQAQSSQIHDLESHST 1619
Query: 1226 ITSALLTEKDAELEKLRNEVTVLRGENASAKS-----------LHSVVQTLESDKVK--- 1271
+ + L E+D E++ R ++ L+ + +Q LE + +
Sbjct: 1620 VLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTK 1679
Query: 1272 -LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLK 1330
LE ++ ++L L+E R+L++ +A+E + ++Q L + + L+ K ++++
Sbjct: 1680 ILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE 1739
Query: 1331 MKVEMMSE 1338
+ E + E
Sbjct: 1740 CQQEHIHE 1747
Score = 160 bits (405), Expect = 8e-39
Identities = 212/1060 (20%), Positives = 447/1060 (42%), Gaps = 104/1060 (9%)
Query: 310 SPSASSLSSMSSVASSVSSR-PSRTGLLTETSSRYARKISG----TTALQEALKEKQQHI 364
+PS L + A S+ R P T L E + K+ T ++ L+++ Q +
Sbjct: 1210 APSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKL 1269
Query: 365 EQLLAERDLERAEV-------AKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMV 417
E+ L + + E+++V + S E + + ++ + ++EL M L++ +
Sbjct: 1270 EERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRL 1329
Query: 418 EAADREKVELLNQLEEEKRKVEDLQFRVEE----------ESITKGDLETQTKLEHARIK 467
A+ +++E + E + E+L +VE ++ G LE + + +K
Sbjct: 1330 RRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALK 1389
Query: 468 ELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKP 527
+ + E+ +A LQ + E + + + L + LA R +EV LR +++ +
Sbjct: 1390 LKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEK 1449
Query: 528 AGDVDMSLSLLQEISSLQEKLEVTRTDHQ----REITSLKEHFGAREETHQKEIKALYTA 583
++ + L + + EV Q + S+ EH + ++++
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509
Query: 584 TEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETA 643
+L K+ E+ ++ LEH E K + I S + +++LK K L T
Sbjct: 1510 IRELEKDRETQRNVLEHQLLE--------LEKKDQMIESQRGQVQDLK----KQLVTLEC 1557
Query: 644 EFAELKTQIEKMRLDYQHEIENLQNQQDSERAA----------HAKEMEALRAK------ 687
EL+ KM Q I+ L+ Q++++R A ++E++A ++
Sbjct: 1558 LALELEENHHKMECQ-QKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616
Query: 688 ----LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNE 743
L + ++E++ +++ R ++++ + Q +D + QE ++ + ++VL+ +
Sbjct: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676
Query: 744 QTKVIDNFTSQLKAT-----EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 798
QTK+++ Q+K + E +++ + EGK K R LE + ++ E
Sbjct: 1677 QTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEK 1736
Query: 799 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 858
E + + E +L L + E S + E+E+ +L+++ EA E+
Sbjct: 1737 EVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGEL 1796
Query: 859 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEND 918
++S+Q ++L + + +LE L++ + + E+ + L A E+
Sbjct: 1797 KEQSLQ---SQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMT 1853
Query: 919 IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS 978
+ E D+ Q ++ +EL ++ R V+ L+ L + +K++ + +Q
Sbjct: 1854 LKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKAL----LALQQQ 1909
Query: 979 QQEAAKKHEEEK--------------KELERKLSDLEKKMETSHNQCQELKARYERATSE 1024
E A++HE E KE +++L L + ++S +Q + +AR E A E
Sbjct: 1910 CAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAE-ALQE 1968
Query: 1025 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK-AKAAQTAEDAMQI 1083
K LQ ++ LL+ + + + L L+ + + + +A + E +Q
Sbjct: 1969 ALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQD 2028
Query: 1084 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEF 1143
+ +E + L + + Q E + L E +L + N +E + ++ EE
Sbjct: 2029 QDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEE- 2087
Query: 1144 RKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMK 1203
EI L Q+ + L+ ++E ++L E R+ E H + S + Q L++
Sbjct: 2088 --EIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPH---SHKTSPMEEQSLKLD 2142
Query: 1204 KRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQ 1263
E + ++ + +A+L++ T A E EK ++ L AS SL V
Sbjct: 2143 SLEPRLQRELERLQAALRQ----TEAREIE---WREKAQDLALSLAQTKASVSSLQEVAM 2195
Query: 1264 TLESDKVKLELKVKNLELQLKENKRQLSS----SSGNTDT 1299
L++ ++ + + + L+ +L+ +R L S G T T
Sbjct: 2196 FLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
Score = 147 bits (370), Expect = 9e-35
Identities = 232/1081 (21%), Positives = 460/1081 (42%), Gaps = 118/1081 (10%)
Query: 347 ISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLEL 406
++ T L++ E+ Q + QL ++ DLE+AE+ + + + + + +++ + L
Sbjct: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
Query: 407 EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARI 466
++ L T + L +EEK ++ + + + + +GD Q H
Sbjct: 310 RETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGS-GHENS 368
Query: 467 KELEQSLL--FEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLES 524
EL+ S+ F+ ADK L R + + +L + LA + V L+++ +
Sbjct: 369 LELDSSIFSQFDYQDADKA---LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQ 425
Query: 525 NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFG----AREETHQKEIKAL 580
+ G LQ+++ ++ L D Q E+ SL + AREE Q +++ L
Sbjct: 426 WEEEGKA--LRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQ-QLEVL 482
Query: 581 YTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGT 640
+L + N L+ + + A + + + +L A+ ++ ++E+ +
Sbjct: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQ----QEELHLAVRERER-LQEMLMGLEAKQSE 537
Query: 641 ETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALR--AKLMKVIKEKENS 698
+E L+ +E L E E L+ +Q AA A+ +++ + +K +
Sbjct: 538 SLSELITLREALESSHL----EGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVAD 593
Query: 699 LEAIRSKLDKAED----------QHLVEMED----TLNKLQEAEIKVKELEVLQAKCNEQ 744
L A KL + Q L+++E+ ++++ AE L+V A+ ++
Sbjct: 594 LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR 653
Query: 745 TKVI----DNFTSQLKATEEKLLDLDA-LRKASSEGKSEMKKL---RQQLEAAEKQIKHL 796
+ + + +QL+ EE +L A LR E + KKL R Q EAA Q++ L
Sbjct: 654 REALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQL 713
Query: 797 EIEKNAESS-------KASSITRELQGRELKLT-------NLQENLSEVSQVKETLEKEL 842
E + + ++ RE E++L +L E L +S KE LE L
Sbjct: 714 HQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL 773
Query: 843 QILKEKFA--EASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLR-ENLADMEAKFR 899
+++ + E ++ + VQ ++ Q E + L D E+ + E D A+
Sbjct: 774 FEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQL 833
Query: 900 EKDERE-----EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL 954
+ E+E EQ A EK N + E K + S ++ L ER+ EL+++L
Sbjct: 834 AQAEQEGKTALEQQKAAHEKEVNQLRE--KWEKERSWHQQELAKALESLEREKMELEMRL 891
Query: 955 TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL-------ERKLSDLEKKMETS 1007
+ +Q E+ +AE + + + E+E+ L +++L+D +++E
Sbjct: 892 KEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERL 951
Query: 1008 HNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ 1067
+ K + + T +T+ +E + L++ D L +EE+S LLQ+ +L+KQ
Sbjct: 952 RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQ 1011
Query: 1068 ADKAKAAQTA-EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEEL 1126
+ K+ A +D+ +++EQ +EK L ++ + +L+ E +L + ++ + L
Sbjct: 1012 VEDLKSQLVAQDDSQRLVEQEVQEK---LRETQEYNRIQKELEREKASLTLSLMEKEQRL 1068
Query: 1127 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK------LAEELGRSRD 1180
+E ++ Q++ R++++ + + S Q+ L++E VK LA+E +
Sbjct: 1069 LVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQE-VKEKEADFLAQEAQLLEE 1127
Query: 1181 EVTSHQKLEEERSVLNNQ-------LLEMKKRESKFIKDADEEK-----------ASLQK 1222
SH ++ R+ L Q L ++ ES+ A E++ ASL
Sbjct: 1128 LEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYS 1187
Query: 1223 SISITSALLTEKDAELE---KLRNEVTVLRGENASAKSLHS---VVQTLESDKVKLELKV 1276
++ + E EL V L + A+SL ++ L ++ V L
Sbjct: 1188 ALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHK 1247
Query: 1277 KNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQR---KNQDLKMKV 1333
+ +L + R + + D A++SQ+ ++ + DLQR +NQ+ K K
Sbjct: 1248 LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV---HTELQDLQRQLSQNQEEKSKW 1304
Query: 1334 E 1334
E
Sbjct: 1305 E 1305
Score = 142 bits (359), Expect = 2e-33
Identities = 236/1119 (21%), Positives = 456/1119 (40%), Gaps = 141/1119 (12%)
Query: 336 LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALA 395
LT S R+ L++ L Q+ + L + D + E KA + + Q+L
Sbjct: 388 LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHD-QWEEEGKA---LRQRLQKLTGE 443
Query: 396 RDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL 455
RD ++L+ ++D L E + + EL QLE +++ L+ RV E +GD
Sbjct: 444 RDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLR-RVNVELQLQGDS 502
Query: 456 -----ETQTKLEHARIKE---LEQSLLFEKTKADKLQRELEDTRVATVSE-------KSR 500
E Q + H ++E L++ L+ + K + EL R A S +
Sbjct: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQE 562
Query: 501 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 560
E+ LA Q +AEL E+ D+ + ++ +S+L E L + + +++
Sbjct: 563 QTEVTAALARAEQSIAELSSS-ENTLKTEVADLRAAAVK-LSALNEALALDKVGLNQQLL 620
Query: 561 SLKEH---FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE 617
L+E +R E ++ AL + K E+L K H + ++L+
Sbjct: 621 QLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAG-AELQ 679
Query: 618 TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH 677
+ Q+ EE++ S+ + A TQ+E++ + + + E L E+ A
Sbjct: 680 ADLRDIQEEKEEIQKKLSESRHQQEAA----TTQLEQLHQEAKRQEEVLARAVQ-EKEAL 734
Query: 678 AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE--DQHLVE--MEDTLNKLQEAEIKVKE 733
+E AL +L V +++++ E ++ E + L E ++++ ++ + +++V+
Sbjct: 735 VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI 794
Query: 734 LEVLQAKCNEQTKV----IDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA 789
V QAK Q +V ++ T + +A +E+ L +A EGK+ L QQ A
Sbjct: 795 QTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA---LEQQKAAH 851
Query: 790 EKQIKHLEIEKNAESS--------KASSITRELQGRELKLTNLQENLSEVSQVKETLEKE 841
EK++ L + E S S+ RE E++L Q + + +E +
Sbjct: 852 EKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQ 911
Query: 842 LQ-ILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL--EKLRENL------- 891
+ L + E +E VS+ ++ +T +L +Q L D+ +KL+E
Sbjct: 912 AESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQT 971
Query: 892 ----ADMEAKFREKDEREE--QLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKER 945
A E K + R++ L + L D ++ K D SQL +D RL E+
Sbjct: 972 QLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQ 1031
Query: 946 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME 1005
+V+E + + N L++ +T+ + +Q E + +++LS L + M+
Sbjct: 1032 EVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR-QQELSALRQDMQ 1090
Query: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD------TEDKLKG---AREENSG 1056
+ + +EL A+ E E K K + L + L + TE +L+ A+E +
Sbjct: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA 1150
Query: 1057 LLQ-ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1115
LQ L Q + A Q + Q Q+ + +L ++ +L D+
Sbjct: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSA 1210
Query: 1116 K-----ENNLKNVEELNKSKELLTV-------------------ENQKMEEFRKEIETLK 1151
E + L K LLT Q + R +++ L+
Sbjct: 1211 PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLE 1270
Query: 1152 QAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKF-- 1209
+ + S + E L +L ++++E + K E +++ L ++L+E+ + +
Sbjct: 1271 ERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS---KWEGKQNSLESELMELHETMASLQS 1327
Query: 1210 -IKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESD 1268
++ A+ ++ Q + A A++E L+ V R + ++A L ++T S
Sbjct: 1328 RLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARS- 1386
Query: 1269 KVKLELKVKNLELQLKENKRQLSSSSGN----------------TDTQADEDERAQ---- 1308
LK+KN E++ + + Q G T T A+ +E +
Sbjct: 1387 ----ALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRG 1442
Query: 1309 ---------ESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
E Q L + +DL+++NQ++ ++ E + E
Sbjct: 1443 QIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQE 1481
Score = 68.6 bits (166), Expect = 4e-11
Identities = 143/712 (20%), Positives = 290/712 (40%), Gaps = 145/712 (20%)
Query: 360 KQQHIEQLLAERDLERAEVAKATSHVGE--------------IEQELALARDGHDQHVLE 405
+Q+HI +L +D ++ VGE ++Q+L AR+ +
Sbjct: 1741 QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS 1800
Query: 406 LEAKMDQLRTMV-------EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQ 458
L++++D+ + + EA +E+ + Q E K K + LQ +E+ +T + +
Sbjct: 1801 LQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGE 1860
Query: 459 TKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAEL 518
+ + + LE+ L E + L+ L D R + ++ ++ L++ A + QE
Sbjct: 1861 LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVE 1920
Query: 519 RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK 578
R L+ D L + ++LE R + Q H +EE + +
Sbjct: 1921 TRALQ--------DSWLQAQAVLKERDQELEALRAESQSS-----RH---QEEAARARAE 1964
Query: 579 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 638
AL E L K + +L+ K +H ++ A LE + A+ Q +++ + + S+ L
Sbjct: 1965 ALQ---EALGKAHAALQGKEQHLLEQ-----AELSRSLEASTATLQASLDACQ-AHSRQL 2015
Query: 639 GTETAEFAELKTQIEKMRLDYQHEIENLQNQ--QDSERAAHAKEMEALRAKLM------K 690
E E + Q + +R YQ +++ LQ Q E H +E E L K +
Sbjct: 2016 -EEALRIQEGEIQDQDLR--YQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN 2072
Query: 691 VIKEKEN---------------SLEAIRSKLDKAEDQHLVEMEDTLNK------------ 723
+I+EK+N S+ ++ L + E Q ++E+ +T +
Sbjct: 2073 MIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKE-QEILELRETQQRNNLEALPHSHKT 2131
Query: 724 --LQEAEIKV--------KELEVLQA----------KCNEQTKVIDNFTSQLKATEEKLL 763
++E +K+ +ELE LQA + E+ + + +Q KA+ L
Sbjct: 2132 SPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQ 2191
Query: 764 DLDALRKASS-EGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL--- 819
++ +AS E SE ++L+ +LE + ++ + +S A +R QG +L
Sbjct: 2192 EVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEV 2251
Query: 820 -------------------KLTNLQENLSEVS-----------QVKETLE---KELQILK 846
+L +LQ+ ++ + Q++ TLE +E + LK
Sbjct: 2252 SGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK 2311
Query: 847 EKFAEASEEAVSVQRSMQETVNKLHQK-EEQFNMLSSDLEKLRENLADMEAKFREKDERE 905
+ A+ +A S++ S + Q Q N + + +L++ + ++A+ + +++
Sbjct: 2312 REAMRAA-QAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQK 2370
Query: 906 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA 957
+ I + ++A + S +S E + E + L LT++
Sbjct: 2371 QDYITRSAQTSRELAG-LHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQS 2421
Score = 37.4 bits (85), Expect = 0.10
Identities = 53/256 (20%), Positives = 115/256 (44%), Gaps = 19/256 (7%)
Query: 1121 KNVEELNKSKELLTVENQKME-EFRKEIETLKQAAAQKSQQLS-ALQEENVKLAEELGRS 1178
+NVEE N + L+ +E ++ E E+ T + +K+ ++ AL+E+ KL + R+
Sbjct: 89 ENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRA 148
Query: 1179 RDEVT---SHQKLEEE--RSVLNNQ---LLEMKKRESKFIKDADEEKASLQKSISITSAL 1230
RDE+ S ++E+E + L + LL + + F + E K++ + + A
Sbjct: 149 RDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAE 208
Query: 1231 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLEL-KVKNLELQLKENKRQ 1289
L +TV G + + + E ++ L L K + LE + E ++
Sbjct: 209 HVRLSGSLLTCCLRLTV--GAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQE 266
Query: 1290 LSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAA--LNGNGDD 1347
L +Q D ++ + ++ L++++ Q++N+D + ++ + E L N +
Sbjct: 267 LIQLK----SQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTE 322
Query: 1348 LNNYDSDDQEKQSKKK 1363
L +++ ++K
Sbjct: 323 LMEHEASLSRNAQEEK 338
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 172 bits (435), Expect = 3e-42
Identities = 250/1086 (23%), Positives = 480/1086 (44%), Gaps = 146/1086 (13%)
Query: 268 KYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVS 327
K+ L A + +VT+ A+ A +R + + LK+ L+ ++ V
Sbjct: 913 KFQLEAKIKEVTERA-EDEEEINAELTAKKRKLEDECSELKKDIDDLELT-LAKVEKEKH 970
Query: 328 SRPSRTGLLTETSSRYARKISGTTALQEALKE-KQQHIEQLLAERDLERAEVAKATSHVG 386
+ ++ LTE S I+ T ++AL+E QQ ++ L AE D + + K S +
Sbjct: 971 ATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNS-LNKTKSKLE 1029
Query: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN---QLEEEKRKVE---- 439
+ ++L + + + ++LE +L ++ A ++L N QL+E +K +
Sbjct: 1030 QQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYC 1089
Query: 440 DLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKS 499
LQ +VE+E + + K ARI+ELE+ + E+ TR T ++S
Sbjct: 1090 QLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA-----------TRAKTEKQRS 1138
Query: 500 RIMELEKDLALRVQEVAEL-RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVT--RTDHQ 556
++L+ R++E + ++E NK + L E ++LQ + V R H
Sbjct: 1139 DYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHA 1198
Query: 557 REITSLKEHFGAREETHQK----------EIKALYTATEKLSKEN-------ESLKSKLE 599
+ L E + QK EI L ++ E +SK +L+ +L
Sbjct: 1199 DSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLS 1258
Query: 600 HANKENSDV------IALWKSKLETAIASHQQAMEE---LKVSFSKGLGTETAEFAELKT 650
A +N ++ + KS+L+T + +EE + S+ T + ELK
Sbjct: 1259 EARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKR 1318
Query: 651 QIE---KMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD 707
Q+E K + H +++ ++ D R + +E E +A+L + + + + + R+K +
Sbjct: 1319 QLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG-KAELQRALSKANSEVAQWRTKYE 1377
Query: 708 KAEDQHLVEMEDTLNKL-QEAEIKVKELEVLQAKCN--EQTKV------------IDNFT 752
Q E+E+ KL Q + +++E + AKC E+TK ++
Sbjct: 1378 TDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERAN 1437
Query: 753 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE----KNAES---S 805
S A ++K + D K +E K++ ++ + +LEA+ K+ + L E KNA
Sbjct: 1438 SLAAALDKKQRNFD---KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALD 1494
Query: 806 KASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE 865
+ ++ RE + E ++ +L E ++E + LEK + + E +Q +++E
Sbjct: 1495 QLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRK-------QIELEKADIQLALEE 1547
Query: 866 TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKM 925
L +E + + +L +++ ++++ K EKDE EQL + ++ E M+
Sbjct: 1548 AEAALEHEEAKILRIQLELTQVK---SEIDRKIAEKDEEIEQLKRNYQR----TVETMQS 1600
Query: 926 SGDNSSQLTKMNDELRLK---ERDVEELQLKLTKANENASFLQKSIEDM--TVKAEQSQQ 980
+ D +++ N+ +RLK E D+ E++++L+ AN A+ K + + +K Q
Sbjct: 1601 ALD--AEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHL 1658
Query: 981 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQK-- 1038
+ A + +E+ KE +L+ +E++ + +EL+A E+ K +E+L + ++
Sbjct: 1659 DDALRGQEDLKE---QLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQ 1715
Query: 1039 -------TLLDTEDKLKGAREENSGLLQELEELRKQADKA--KAAQTAEDAMQIMEQMTK 1089
+L+ T+ KL+ + L E+E+ + A A KA + DA + E++ K
Sbjct: 1716 LLHTQNTSLIHTKKKLE---TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKK 1772
Query: 1090 EKTETLASLEDTK----QTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRK 1145
E+ +T A LE K QT LQ+ LD ++ LK ++ + QK+E +
Sbjct: 1773 EQ-DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK----------QIQKLETRIR 1821
Query: 1146 EIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMK-- 1203
E+E + +K+ E+VK + R E+T +Q E+ ++VL Q L K
Sbjct: 1822 ELEFELEGEQKKN-------TESVKGLRKYERRVKELT-YQSEEDRKNVLRLQDLVDKLQ 1873
Query: 1204 ---KRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS 1260
K + ++ADE+ + L E + + ++V LR + S
Sbjct: 1874 VKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRM 1933
Query: 1261 VVQTLE 1266
VV E
Sbjct: 1934 VVHESE 1939
Score = 166 bits (421), Expect = 1e-40
Identities = 256/1134 (22%), Positives = 481/1134 (42%), Gaps = 199/1134 (17%)
Query: 346 KISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLE 405
K + T +KE+ Q + LA+ + +R E+ + + + + +L L +++L+
Sbjct: 842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 406 LEAKMDQL-----------RTMVEAADREKVELLNQLEEEKRKVED----LQFRVEEESI 450
E + DQL + + E A+ E+ E+ +L +KRK+ED L+ +++ +
Sbjct: 902 AEERCDQLIKAKFQLEAKIKEVTERAEDEE-EINAELTAKKRKLEDECSELKKDIDDLEL 960
Query: 451 TKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRE----------------LEDTRVAT 494
T +E + ++K L + L KL RE E+ +V +
Sbjct: 961 TLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNS 1020
Query: 495 VSE-KSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSL---SLLQ----------- 539
+++ KS++ + +DL +++ +LR LE NK + D+ L S+L
Sbjct: 1021 LNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER 1080
Query: 540 ------EISSLQEKLEVTRT---DHQREITSLKEHFGAREETHQKEIKALYTATEK---- 586
E LQ K+E +T Q++I L+ EE + E +A TEK
Sbjct: 1081 LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAE-RATRAKTEKQRSD 1139
Query: 587 LSKENESLKSKLEHANKENSDVIALWKSK----------LETAIASHQQAMEELKVSFSK 636
++E E L +LE A S I L K + LE A H+ + L+ +
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199
Query: 637 G---LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 693
LG + +K ++EK + +++ EI++L + +S + +A L K+ +
Sbjct: 1200 SVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMES--------VSKSKANLEKICR 1251
Query: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ----EAEIKVKELEVLQAKCNEQTKVID 749
E+ L R K ++ + + L E+ ++LQ E +++E E + ++ + +
Sbjct: 1252 TLEDQLSEARGKNEEIQ-RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT 1310
Query: 750 NFTSQLKAT-EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 808
T +LK EE+ +AL A + + LR+Q E E+Q E+++ SKA+
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYE--EEQEGKAELQRAL--SKAN 1366
Query: 809 SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRS---MQE 865
S Q R T+ + E+ + K+ L + LQ +E+ + + S++++ +Q
Sbjct: 1367 S--EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG 1424
Query: 866 TVNKLHQKEEQFNMLSSDLEKLRENL---------------ADMEAKFREKDEREEQLIK 910
V L E+ N L++ L+K + N A++EA +E +L K
Sbjct: 1425 EVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFK 1484
Query: 911 AK-----------------EKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLK 953
K + LE +IA++ + +N + ++ + E + ++QL
Sbjct: 1485 LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA 1544
Query: 954 LTKA-----NENASFLQKSIEDMTVKAEQSQQEAAKKHEEE--KKELERKLSD------- 999
L +A +E A L+ +E VK+E ++ A K E E K+ +R +
Sbjct: 1545 LEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA 1604
Query: 1000 ----------LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1049
L+KKME N+ + + R +ET + L+ T L +D L+G
Sbjct: 1605 EVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRG 1664
Query: 1050 AR---------EENSGLLQ-ELEELR---KQADKAK--AAQTAEDAMQIMEQMTKEKTET 1094
E + LLQ E+EELR +Q ++A+ A Q D+ + ++ + + T
Sbjct: 1665 QEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSL 1724
Query: 1095 LASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAA 1154
+ + + + +LQ+E++ + +N EE K+K+ +T EE +KE +T
Sbjct: 1725 IHTKKKLETDLMQLQSEVED-ASRDARNAEE--KAKKAITDAAMMAEELKKEQDT----- 1776
Query: 1155 AQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1214
S L +++ + ++L DE ++L + Q LE + RE +F + +
Sbjct: 1777 ---SAHLERMKKNLEQTVKDLQHRLDEA---EQLALKGGKKQIQKLETRIRELEFELEGE 1830
Query: 1215 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLEL 1274
++K TE L K V L ++ + +Q L KL++
Sbjct: 1831 QKKN-------------TESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVD---KLQV 1874
Query: 1275 KVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQD 1328
KVK+ + Q +E Q ++ E E A+E + D S + L+ K +D
Sbjct: 1875 KVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEE-RADIAESQVNKLRAKTRD 1927
Score = 146 bits (368), Expect = 2e-34
Identities = 150/703 (21%), Positives = 309/703 (43%), Gaps = 76/703 (10%)
Query: 716 EMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL----DALRKA 771
E + T ++L ++E K KELE K + ++ Q++A E LLD D L KA
Sbjct: 856 EFQKTKDELAKSEAKRKELE---EKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKA 912
Query: 772 SSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEV 831
+ ++++K++ ++ E E+ L +K + S + +++ EL L +++
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 972
Query: 832 SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 891
+ L +EL L E A+ + E ++Q + Q+ ++ L +E++ N L+ KL + +
Sbjct: 973 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQV 1032
Query: 892 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQ 951
D+E+ ++ + L + K KLE D+ + D + ++++ L+ K+ + +LQ
Sbjct: 1033 EDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQ 1092
Query: 952 LKLTKANENASFLQKSIEDMTVKAEQSQQE------AAKKHEEEKKELERKLSDLEKKME 1005
K+ QK I+++ + E+ ++E K E+++ + R+L +L +++E
Sbjct: 1093 SKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLE 1152
Query: 1006 TS---------------------HNQCQELKARYERATSETKTKHE-------EILQNLQ 1037
+ +E ++E + + KH E + NLQ
Sbjct: 1153 EAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQ 1212
Query: 1038 KTLLDTEDKLKGAREENSGLLQELEELRK-QADKAKAAQTAEDAMQIMEQMTKEKTETLA 1096
+ E + + E L +E + K +A+ K +T ED + +E +L+
Sbjct: 1213 RVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLS 1272
Query: 1097 SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1156
L K EL E V +L++SK+ T + ++++ +E K A A
Sbjct: 1273 ELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAH 1332
Query: 1157 KSQ-----------QLSALQEENVKLAEELGRSRDEVTS-HQKLEEERSVLNNQLLEMKK 1204
Q Q QE +L L ++ EV K E + +L E KK
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1392
Query: 1205 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT 1264
+ ++ ++D++E+ + +A + ++L+ EV L + A SL + +
Sbjct: 1393 KLAQRLQDSEEQ-------VEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 1445
Query: 1265 LES--DKVKLELKVKNLELQLKENKRQLSSS---SGNTDTQADEDERAQESQIDFLNSVI 1319
+ DKV E K K +E++ +L +S S + T+ + + A E +D L +V
Sbjct: 1446 KQRNFDKVLAEWKTK-----CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETV- 1499
Query: 1320 VDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKK 1362
+R+N++L+ ++ ++E + NG ++ + ++ + +K
Sbjct: 1500 ---KRENKNLEQEIADLTE-QIAENGKTIHELEKSRKQIELEK 1538
Score = 115 bits (287), Expect = 4e-25
Identities = 124/537 (23%), Positives = 241/537 (44%), Gaps = 70/537 (13%)
Query: 839 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 898
EKE+ +KE+F + +E + +E KL ++ N L ++ ENL D E
Sbjct: 847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE--- 903
Query: 899 REKDEREEQLIKAKEKLENDIAEIMKMSGDN---SSQLT----KMNDELRLKERDVEELQ 951
ER +QLIKAK +LE I E+ + + D +++LT K+ DE ++D+++L+
Sbjct: 904 ----ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 959
Query: 952 LKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEK---KELERKLSDLEKKMETSH 1008
L L K + + ++++T + + AK E+K + ++ L DL+ + E
Sbjct: 960 LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE-EDKV 1018
Query: 1009 NQCQELKARYERATSETKTKHEE---ILQNLQKTLLDTEDKLKGAREENSGLLQELEEL- 1064
N + K++ E+ + ++ E+ + +L++ E LK A+E L + ++L
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 1078
Query: 1065 ----RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ-------TNAKLQNELD 1113
+K + + ED + Q K+ E A +E+ ++ T AK + +
Sbjct: 1079 ERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQ-- 1136
Query: 1114 TLKENNLKNVEELNKSKE--------LLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQ 1165
+ + + +EEL++ E + + ++ EF K L++A Q ++AL+
Sbjct: 1137 --RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR 1194
Query: 1166 EENVKLAEELGRSRDEVTS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1224
+++ ELG D + QKLE+E+S ++ ++ S ++ + KA+L+K
Sbjct: 1195 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDL----SSSMESVSKSKANLEKI- 1249
Query: 1225 SITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK 1284
L ++++ RG+N + + + L + K +L+ + L QL+
Sbjct: 1250 -------------CRTLEDQLSEARGKN---EEIQRSLSELTTQKSRLQTEAGELSRQLE 1293
Query: 1285 ENK---RQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
E + QLS S Q +E +R E + N++ LQ D + E E
Sbjct: 1294 EKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEE 1350
Score = 102 bits (254), Expect = 3e-21
Identities = 132/629 (20%), Positives = 265/629 (42%), Gaps = 58/629 (9%)
Query: 320 SSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVA 379
+++A ++ S LL E +Y + G LQ AL + + Q R +
Sbjct: 1328 NALAHALQSSRHDCDLLRE---QYEEEQEGKAELQRALSKANSEVAQW---RTKYETDAI 1381
Query: 380 KATSHVGEIEQELALARDGHDQHVLELEAK---------------------MDQLRTMVE 418
+ T + E +++LA ++ V + AK +++ ++
Sbjct: 1382 QRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAA 1441
Query: 419 AADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQT-KLEHARIKELEQSLLFEK 477
A D+++ L E K K E+ Q +E L T+ KL++A + L+Q L K
Sbjct: 1442 ALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQ-LETVK 1500
Query: 478 TKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL 537
+ L++E+ D I ELEK E A+++ LE + A + + + L
Sbjct: 1501 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKIL 1560
Query: 538 LQEISSLQEKLEVTR--TDHQREITSLKEHFGAREETHQKEIKALYTAT-------EKLS 588
++ Q K E+ R + EI LK ++ ET Q + A + +K+
Sbjct: 1561 RIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKME 1620
Query: 589 KENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL 648
+ ++ +L HAN++ ++ + + S Q +++ ++ L + + E
Sbjct: 1621 GDLNEIEIQLSHANRQAAETLK--------HLRSVQGQLKDTQLHLDDALRGQE-DLKEQ 1671
Query: 649 KTQIEKMRLDYQHEIENLQ-NQQDSERAAHAKEMEALRA-KLMKVIKEKENSLEAIRSKL 706
+E+ Q E+E L+ + +ERA E E L + + ++++ + SL + KL
Sbjct: 1672 LAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKL 1731
Query: 707 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL- 765
+ Q E+ED + AE K K+ A E+ K + ++ L+ ++ L
Sbjct: 1732 ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1791
Query: 766 -DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNL 824
D + + +K ++Q++ E +I+ LE E E K + + L+ E ++ L
Sbjct: 1792 KDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKEL 1851
Query: 825 -------QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877
++N+ + + + L+ +++ K + EA E+A + ++ ++L + EE+
Sbjct: 1852 TYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERA 1911
Query: 878 NMLSSDLEKLRENLADMEAKFREKDEREE 906
++ S + KLR D + E EE
Sbjct: 1912 DIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
Score = 52.0 bits (123), Expect = 4e-06
Identities = 64/283 (22%), Positives = 115/283 (40%), Gaps = 38/283 (13%)
Query: 1057 LLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK 1116
L +++ L K A+ K T ++ Q KT+ D L
Sbjct: 833 LFFKIKPLLKSAETEKEMATMKEEFQ--------KTK-------------------DELA 865
Query: 1117 ENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELG 1176
++ K E K L+ +N + + E E L A + Q + A + K+ E
Sbjct: 866 KSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTE 925
Query: 1177 RSRDEVTSHQKLEEERSVLNNQLLEMKKRESKF---IKDADEEKASLQKSISITSALLTE 1233
R+ DE + +L ++ L ++ E+KK + ++EK + + + + L+
Sbjct: 926 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSG 985
Query: 1234 KDAELEKLRNEVTVLRGENASA----KSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ 1289
D + KL E L+ + A ++ V +L K KLE +V++LE L++ K+
Sbjct: 986 LDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKL 1045
Query: 1290 LSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMK 1332
N + + AQES +D N D Q+ ++ LK K
Sbjct: 1046 RVDLERNKRKLEGDLKLAQESILDLEN----DKQQLDERLKKK 1084
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 170 bits (431), Expect = 8e-42
Identities = 228/1051 (21%), Positives = 463/1051 (44%), Gaps = 144/1051 (13%)
Query: 353 LQEALKEKQQHIEQLLAERDLER--AEVAKA-------TSHVGEIEQELALARDGHDQHV 403
LQEA ++IE L D R +E+ K+ + + +E+EL LARD + ++
Sbjct: 993 LQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN- 1051
Query: 404 LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEH 463
+DQ +A + L LEE KR+ E L + ++++ K +
Sbjct: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAE-LDGKSAKQNLDKC---------Y 1101
Query: 464 ARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRR--- 520
+IKEL + K +L E+ED + S + R + + D ++Q+ + +
Sbjct: 1102 GQIKELNE-------KITRLTYEIEDEKRRRKSVEDRFDQQKNDYD-QLQKARQCEKENL 1153
Query: 521 ---RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAR----EETH 573
+LES K + + + L+ + LQE+ + +++ E+ ++ H+ +
Sbjct: 1154 GWQKLESEKAIKEKEYEIERLRVL--LQEE-GTRKREYENELAKVRNHYNEEMSNLRNKY 1210
Query: 574 QKEIKALYTATEKLSKENE----SLKSKLEHANKENSD----VIALWKSKLETAIASHQQ 625
+ EI T +++S + E +L+++L+ ++EN D ++ L S L+ A+ Q+
Sbjct: 1211 ETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQ---ATEQR 1267
Query: 626 AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA-----KE 680
E K G+E + + +IE ++ Q +N +++Q E AA KE
Sbjct: 1268 RRAEENALQQKACGSEIMQ-KKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
Query: 681 MEALRAKLMKVIK---EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVL 737
+E L+A+ + K E EN L +R+ D+ ++ +++ E EI + + +
Sbjct: 1327 IERLKAEFQEEAKRRWEYENELSKVRNNY----DEEIISLKNQF----ETEINITKTTIH 1378
Query: 738 QAKCNEQTKV------IDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEK 791
Q ++ IDN T + ++ E++ L ++E +++ QQ +A
Sbjct: 1379 QLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGS 1438
Query: 792 QI----KHLEIE-KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL---Q 843
++ + LE+E + + R Q + +Q+ E+ ++K+ ++KE +
Sbjct: 1439 EVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRK 1498
Query: 844 ILKEKFAEASEEAVSVQR---SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 900
L+++ A +Q+ S ET+NKL +E++ L D E++ + +
Sbjct: 1499 CLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558
Query: 901 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLK---LTKA 957
++L K+K+E ++ + + + ++S + K+ +EL R ++E +K LT+
Sbjct: 1559 FQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQ 1618
Query: 958 NENASFLQKSIEDMT----------VKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETS 1007
E AS ++K ED ++ +Q QE ++ E + L R+L ++ ++ +
Sbjct: 1619 LEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQA 1678
Query: 1008 HNQCQELKARYE---RATSETKTKHE---EILQNLQKTLLDTEDKLKGAREENSGLLQEL 1061
H + + + E R+ +E+K + E + +NL K L E++L+ R E +L
Sbjct: 1679 HLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLE----YDDL 1734
Query: 1062 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL-EDTKQTNAKLQNELDTLKENNL 1120
R +AD K A E Q+ Q++ +T L L D ++ L+ E++ ++ L
Sbjct: 1735 RRGRSEADSDKNATILELRSQL--QISNNRTLELQGLINDLQRERENLRQEIEKFQKQAL 1792
Query: 1121 KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1180
+ + +SK T Q+ E +I+ L+Q A+ +L +EL R++
Sbjct: 1793 EASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ-----------RLEDELNRAKS 1841
Query: 1181 ----EVTSHQKLEEERSVLNNQLLEMK----KRESKFIKDADEEKASLQKSISITSALLT 1232
E Q+LE E+ + N L + K ++E K E + S ++ S+ S
Sbjct: 1842 TLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRS---- 1897
Query: 1233 EKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSS 1292
E+E+L+ E+ R E + L + +S +LE + + ++ + +++
Sbjct: 1898 ----EIERLQAEIK--RIEERCRRKLEDSTRETQS---QLETERSRYQREIDKLRQRPYG 1948
Query: 1293 SSGNTDTQADEDERAQESQIDFLNSVIVDLQ 1323
S T T+ + + D L + +Q
Sbjct: 1949 SHRETQTECEWTVDTSKLVFDGLRKKVTAMQ 1979
Score = 144 bits (364), Expect = 5e-34
Identities = 197/939 (20%), Positives = 393/939 (41%), Gaps = 189/939 (20%)
Query: 466 IKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLA----------LRVQEV 515
+K LE L + TK + L+ EL R A ++ L+++L ++ +
Sbjct: 1021 LKSLED-LKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASL 1079
Query: 516 AELRRR--LESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETH 573
EL+R+ L+ ++D ++E++ +L D +R S+++ F ++ +
Sbjct: 1080 EELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
Query: 574 QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS 633
+ KA KEN + K + E AI + +E L+V
Sbjct: 1140 DQLQKA-------------------RQCEKEN---LGWQKLESEKAIKEKEYEIERLRVL 1177
Query: 634 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 693
+ GT E+ + ++ K+R Y E+ NL+N+ ++E + + + ++
Sbjct: 1178 LQEE-GTRKREY---ENELAKVRNHYNEEMSNLRNKYETE-------INITKTTIKEISM 1226
Query: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 753
+KE+ + +R++LD+ ++ +++D + +L ++ +LQA T
Sbjct: 1227 QKEDDSKNLRNQLDRLSRENR-DLKDEIVRLNDS--------ILQA------------TE 1265
Query: 754 QLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA-SSITR 812
Q + EE L A SE+ + +Q LE KQ+ E NA ++ +
Sbjct: 1266 QRRRAEENALQQKACG-------SEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAK 1318
Query: 813 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN---- 868
+Q + ++ L+ E ++ + E EL ++ + EE +S++ + +N
Sbjct: 1319 TIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNY---DEEIISLKNQFETEINITKT 1375
Query: 869 KLHQ----KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMK 924
+HQ KEE + + ++ L + + + Q + ++E DI + K
Sbjct: 1376 TIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQ-QK 1434
Query: 925 MSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK 984
+G SQ R ++ +VE Q+ + E+ V+ +QS +AAK
Sbjct: 1435 ATGSEVSQ--------RKQQLEVELRQVTQMRTEES------------VRYKQSLDDAAK 1474
Query: 985 KHEEEKKELERKLSDLEKKMETSHNQC-QELKARYERATSETKTKHEEILQNLQKTLLDT 1043
+++ KE+ER ++K ET+ +C ++ AR +R + LQ + +T
Sbjct: 1475 TIQDKNKEIERLKQLIDK--ETNDRKCLEDENARLQRVQYD--------LQKANSSATET 1524
Query: 1044 EDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1103
+KLK QEL LR ++ +T +D Q
Sbjct: 1525 INKLKVQE-------QELTRLRIDYERVSQERTVKD-----------------------Q 1554
Query: 1104 TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK------ 1157
+ QN L L+ K EELN+ K + ++ K ++ +E+E ++++ ++
Sbjct: 1555 DITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITN 1614
Query: 1158 -SQQLSALQEENVKLAEELGRSRDEVTSH----QKLEEERSVLNNQLLEMKK---RESKF 1209
+QQL + ++L + RD + H Q+ +EE L++++ +++ +E +
Sbjct: 1615 LTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQES 1674
Query: 1210 IKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDK 1269
+K A QK+I S L E E+E+L+ S+ + L +
Sbjct: 1675 VKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ-----------------SLTENLTKEH 1717
Query: 1270 VKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQID-----FLNSVIVDLQR 1324
+ LE +++NL L+ + +R S ++D A E + QI L +I DLQR
Sbjct: 1718 LMLEEELRNLRLEYDDLRR--GRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQR 1775
Query: 1325 KNQDLKMKVEMMSEAALNGNG---DDLNNYDSDDQEKQS 1360
+ ++L+ ++E + AL + + N QE++S
Sbjct: 1776 ERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERES 1814
Score = 103 bits (256), Expect = 2e-21
Identities = 161/812 (19%), Positives = 339/812 (41%), Gaps = 126/812 (15%)
Query: 359 EKQQHIEQLLAERDLERAEVAKATSHVG-EIEQELALARDGHDQHVLELEAKMDQLRTMV 417
E+++ E+ ++ +E+ + H+ E++Q + + + +H LE ++
Sbjct: 1265 EQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKN 1324
Query: 418 EAADREKVELLNQLE---EEKRKVEDLQFRVEEESIT-KGDLETQTKLEHARIKEL---- 469
+ +R K E + + E + ++ ++ +EE I+ K ET+ + I +L
Sbjct: 1325 KEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQK 1384
Query: 470 EQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAG 529
E+ + + D L RE S I L+ L + + + ++ K G
Sbjct: 1385 EEDTSGYRAQIDNLTRENR-------SLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATG 1437
Query: 530 DVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK 589
E+S +++LEV R++T ++ R + ++L A + +
Sbjct: 1438 S---------EVSQRKQQLEV----ELRQVTQMRTEESVRYK------QSLDDAAKTIQD 1478
Query: 590 ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELK 649
+N+ ++ + +KE +D + LE A Q+ +L+ + S TET +++
Sbjct: 1479 KNKEIERLKQLIDKETND-----RKCLEDENARLQRVQYDLQKANSSA--TETINKLKVQ 1531
Query: 650 TQ-IEKMRLDYQH-EIENLQNQQDSERAAHA-KEMEALRAKLMKVIKEKENSLEAIRSKL 706
Q + ++R+DY+ E QD R ++ KE++ + K+ + + + + K
Sbjct: 1532 EQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKR 1591
Query: 707 DKAEDQHLVEMEDTLNKLQEAEIKVKEL--EVLQAKC---------NEQTKVIDNFTSQL 755
K E+ E+E L+E IK+ L ++ QA +Q V+D +
Sbjct: 1592 KKLEE----ELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREK 1647
Query: 756 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQ 815
+ T+E+L L SE++ LR+QL ++ +K + +R L
Sbjct: 1648 QRTQEELRRLS----------SEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLN 1697
Query: 816 GRELKLTNLQENLSEVSQVKETLEKELQILKEKF-------AEASEEAVSVQRSMQETVN 868
++++ LQ +++ LE+EL+ L+ ++ +EA + + ++ +
Sbjct: 1698 ESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQ 1757
Query: 869 KLHQKEEQFNMLSSDLEKLRENLADMEAKFREK-------------------DEREEQLI 909
+ + + L +DL++ RENL KF+++ ERE L+
Sbjct: 1758 ISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLV 1817
Query: 910 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKER-DVEELQLKLTKANENASFLQKSI 968
K K LE D A + ++ + + + + E R+K+R + E+ Q++ + +K
Sbjct: 1818 KIKV-LEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRK-- 1874
Query: 969 EDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER----ATSE 1024
+EA +K E E+++ ER+ + L ++E + + ++ R R +T E
Sbjct: 1875 -----------EEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1923
Query: 1025 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAK----AAQTAEDA 1080
T+++ E Q+ + + G+ E E D +K + A
Sbjct: 1924 TQSQLETERSRYQREIDKLRQRPYGSHRETQ------TECEWTVDTSKLVFDGLRKKVTA 1977
Query: 1081 MQIMEQMTKEKTETLASLEDTKQTNAKLQNEL 1112
MQ+ E +KT TL L K++ ++ +E+
Sbjct: 1978 MQLYECQLIDKT-TLDKLLKGKKSVEEVASEI 2008
Score = 92.0 bits (227), Expect = 4e-18
Identities = 144/667 (21%), Positives = 285/667 (42%), Gaps = 89/667 (13%)
Query: 296 VRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSR--------TGLLTETSSRYARKI 347
++ + T+ +L+R + + S VS R + T + TE S RY + +
Sbjct: 1412 LKNTLTQTTENLRRVEE--DIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSL 1469
Query: 348 SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELE 407
+ ++ + ++QL+ + +R + + + ++ +L A + + +L+
Sbjct: 1470 DDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLK 1529
Query: 408 AKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIK 467
+ +L + D E+V ++R V+D + S+ +L+ Q + +
Sbjct: 1530 VQEQELTRL--RIDYERV-------SQERTVKDQDITRFQNSLK--ELQLQKQKVEEELN 1578
Query: 468 ELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDL--ALRVQEVAELRRRLESN 525
L+++ + K KL+ ELE R + + +I L + L A V++ +E R + +
Sbjct: 1579 RLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD 1638
Query: 526 KPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK------EHFGAREETHQK---- 575
G + +E+ L ++E R +E S+K EHF E +
Sbjct: 1639 VLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE 1698
Query: 576 ---EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKV 632
EI+ L + TE L+KE+ L+ +L + E D+ A+ + +L++
Sbjct: 1699 SKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQI 1758
Query: 633 SFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQ--QDSERAAHAKEMEALRAKLMK 690
S T E L +++ R + + EIE Q Q + S R +K + +
Sbjct: 1759 S-----NNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKN------QCTQ 1807
Query: 691 VIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ---EAEIKVKELEVLQAKCNEQTKV 747
V++E+E+ L ++ K+ + + L +ED LN+ + EAE +VK+ + +C +Q
Sbjct: 1808 VVQERESLL--VKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQ----RLECEKQQ-- 1859
Query: 748 IDNFTSQLKATEEKLLDLDALRKASSE-GKSEMKK--LRQQLEAAEKQIKHLEIEKNAES 804
I N +Q K + +A+RK SE KSE +K LR ++E + +IK +E
Sbjct: 1860 IQNDLNQWKTQYSR--KEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE---ERCR 1914
Query: 805 SKASSITRELQGR-ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASE--------- 854
K TRE Q + E + + Q + ++ Q +E Q E + S+
Sbjct: 1915 RKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKK 1974
Query: 855 ----EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE---NLADMEAKFREKDEREEQ 907
+ Q + T++KL + ++ ++S+++ ++A A +EK
Sbjct: 1975 VTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEK----YS 2030
Query: 908 LIKAKEK 914
L++AK K
Sbjct: 2031 LVEAKRK 2037
Score = 30.8 bits (68), Expect = 9.7
Identities = 29/159 (18%), Positives = 74/159 (46%), Gaps = 10/159 (6%)
Query: 966 KSIEDMTVKAEQ---SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERAT 1022
K+I D+ + ++ + Q + +++K++++ + +D +K +T Q +++ T
Sbjct: 578 KTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYP-QHQTVT 636
Query: 1023 SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAED--- 1079
+ T H +++T + ++ + +L EL+++R+Q + + T ++
Sbjct: 637 TTEITHHGTCQDVNHNKVIETN---RENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPL 693
Query: 1080 AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKEN 1118
A Q K L S+++ Q A++ N+L + N
Sbjct: 694 ADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLAN 732
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 169 bits (428), Expect = 2e-41
Identities = 242/1068 (22%), Positives = 469/1068 (43%), Gaps = 123/1068 (11%)
Query: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
+AL+EK +++L +EV++ + +IE A + + + + LE K L
Sbjct: 313 DALREKAVRVDKL-------ESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT-MLE 364
Query: 415 TMVEAADREKVELLNQLEEE----KRKVEDLQFRVEEESITKGDL-ETQTKLEHARIKEL 469
+E R + + L++LE+E K K+ D++ + + +L E LE A+ + +
Sbjct: 365 DQLEGT-RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
Query: 470 EQSL-----LFEKTKADKLQRELEDTRVATVSE--KSRIMELEKDLALRVQEVAELRRRL 522
++SL L + ++ +L + + V+E SR+++LE + + V ELR +
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV 483
Query: 523 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 582
+S + G+ L + +E L +K+E+ + +E SL+ ++ KE L
Sbjct: 484 DSVE--GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL-MKEKAQLEK 540
Query: 583 ATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTET 642
E L + +E LE N+ + ++ + + + + + + +E+ + + +
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 643 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH--AKEMEALRAKL--MKVIKEKENS 698
++ ++++ + +++ + +H E + ++ E H KE E L+ K+ +K+ EK +
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 699 LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 758
LE S+L++ + ++ TL+ + +++ LE ++ +E+ + LK
Sbjct: 661 LEQENSELERENRK----LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCA 716
Query: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
K+ L K K ++KK + L+A+ K+ + LE+ + + + L+
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
Query: 819 LKLTNLQENLSEVSQVKETLEKELQILK---EKFAEASEEAVSVQRSMQETVNKLHQKEE 875
K+ L+ L ++ +TL+K L+ LK ++ + +E S+++ + Q E+
Sbjct: 777 KKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK 836
Query: 876 QFNMLSSDLEKLRENLADMEAKF--REKDER---------EEQLIKAKEKLENDIAEIMK 924
+ L E L + K EK+ + +E ++ KE LE + E++K
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE-LEKENKELVK 895
Query: 925 MSGDNSSQLTKMNDEL---RLK----ERDVEELQLKLTKANENASFL---QKSIEDMTVK 974
+ + L + ++L +LK D+E+L +L K N L ++S +D
Sbjct: 896 RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKL 955
Query: 975 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL-------KARYER------- 1020
E + KK E K+E K++ LE ++E S N Q+L K YE
Sbjct: 956 LESKLESTLKKSLEIKEE---KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1012
Query: 1021 --------ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAK 1072
S K E Q + LL +D+L N+ L E + L+ Q K
Sbjct: 1013 ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ---LK 1069
Query: 1073 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQT-NAKLQNELDTLKENNLKNVEELNKSKE 1131
+T + +Q + +T +L T QT NAKLQ E TL N ++ +N++ +
Sbjct: 1070 QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL---NSQSTSLMNQNAQ 1126
Query: 1132 LLTV------ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS- 1184
LL EN+ + + R+++++L + + ++L L E E L + S
Sbjct: 1127 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA 1186
Query: 1185 HQKLEEERSVLN---NQLLEMKKRESKFIK--DADEEKASLQKSISITSA-----LLTEK 1234
H+ LE E L NQLL+ K + K ++EK L+ T A L E
Sbjct: 1187 HKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN 1246
Query: 1235 DA---ELEKLRNEVTVLRGENASAKSL---HSVVQT-LESDKVKLELKVKNLEL---QLK 1284
D +L E VL+ ++ + KSL + QT LE++ KL+ + + L++ +L
Sbjct: 1247 DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1306
Query: 1285 ENKRQLSSSSGNTDTQADEDERAQESQIDFL---NSVIVDLQRKNQDL 1329
LS GN +E+ R QI L N +++ +++DL
Sbjct: 1307 NQCELLSQLKGN----LEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1350
Score = 163 bits (412), Expect = 1e-39
Identities = 245/1150 (21%), Positives = 483/1150 (42%), Gaps = 185/1150 (16%)
Query: 334 GLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA 393
GL +T + A I T QE + + Q +++ D+E + H+ + E
Sbjct: 147 GLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPL-LKNMALHLKRLIDE-- 203
Query: 394 LARDGHDQHVLELEAKMDQLRTM------------------VEAADREKVELLNQLEEEK 435
RD H + ++EL + D L + E+ VEL + + +
Sbjct: 204 --RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIR 261
Query: 436 RKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATV 495
R ++L+ + E+ K +LE Q ++E R+++ +LL + A + EL+ R V
Sbjct: 262 RLRQELEEKTEQLLDCKQELE-QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAV 320
Query: 496 ------SE--------------KSRIMELEKDLALRVQEVAELRRRLESNKPAGDV---- 531
SE K+R+ EL++D + ++ L +LE + D
Sbjct: 321 RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL 380
Query: 532 ------------DMSLSLLQEISSLQEKLEVTRTDHQREITSLKE--HFG---------- 567
DM + + ++E +E T + S+ E H G
Sbjct: 381 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTS 440
Query: 568 ----AREETHQKEIKALYTA--------TEKLSKENESLKSKLEHANKENSDVIALWKSK 615
A +++ E+ L ++ + L+K E L++ ++ S ++ + K
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKEN 500
Query: 616 ---------LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL 666
LE I +Q+++ + + SK L E A+L+ IE +R + + +I+ L
Sbjct: 501 QRLSKKVEILENEIVQEKQSLQNCQ-NLSKDL---MKEKAQLEKTIETLRENSERQIKIL 556
Query: 667 --QNQQDSERAAHAKEMEALRAKLMKVIKEKEN-----SLEAIRSKLDKAEDQHLVEMED 719
+N+ ++ + ++ + A+ EKEN S++ SKL K E + +++
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR-QIKK 615
Query: 720 TLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEM 779
L +E + +ELE ++ +++ + LK T EK ++AL + +SE + E
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEK---IEALEQENSELEREN 672
Query: 780 KKLRQ----------QLEAAEKQ-----IKHLEIEKNAESSKASSITRELQGRELKLTNL 824
+KL++ QLE+ EK+ ++LE+ +N ES K +S +K+ L
Sbjct: 673 RKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCAS---------MKMAQL 723
Query: 825 QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ------RSMQETVNKLHQKEEQFN 878
Q E+ KE L+K L++LK F + VS Q + +Q+T+ ++K +Q
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 879 MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 938
DLE + L + + +R EQL K + LE + +++ K + QL K N
Sbjct: 784 SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK----DKKQLEKENK 839
Query: 939 ELR----LKERDVEELQLKLTKANENASFLQKSI---EDMTVKAEQSQQEAAK------- 984
LR +K+ +EE +K+ + L K I ++ V+ ++ ++E +
Sbjct: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899
Query: 985 -----------------KHEEEKKELERKLSDLEK----KMETSHNQCQELKARYERATS 1023
K ++ +LE+ +LEK K H++ Q RY+ S
Sbjct: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE-QSTDDRYKLLES 958
Query: 1024 ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQI 1083
+ ++ ++ L+ ++ + E +L+ + N L QEL+ ++K + K Q E +Q
Sbjct: 959 KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS 1018
Query: 1084 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEF 1143
++ E + ++T + K+++ L ++ NN E K L +
Sbjct: 1019 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1078
Query: 1144 RKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMK 1203
+ +I L++ +Q + LQ +N KL E + TS L + + L Q ++
Sbjct: 1079 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTS---LMNQNAQLLIQQSSLE 1135
Query: 1204 KRESKFIKDADEEKA---SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS 1260
IK+ ++ K+ SL K L + +E E L ++ L+ + + + H
Sbjct: 1136 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1195
Query: 1261 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV 1320
++ + +K + ++++LE LK + ++ + N +T A E ++ + D LN
Sbjct: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC-GENDRLNHTYS 1254
Query: 1321 DLQRKNQDLK 1330
L ++ + L+
Sbjct: 1255 QLLKETEVLQ 1264
Score = 114 bits (285), Expect = 7e-25
Identities = 136/608 (22%), Positives = 274/608 (45%), Gaps = 64/608 (10%)
Query: 794 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 853
+HL +E +K + +EL+ + E L + Q E +E EL+ L+++
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEK-------TEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 854 EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADME---AKFREKDEREEQLIK 910
+A S R ++ ++ L +K + + L S++ + +E L D+E A+ E E + L++
Sbjct: 300 SDARSA-RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLE 358
Query: 911 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK------ERDVEELQL-KLTKANENASF 963
K LE+ + E + D +L K N +L+ K ERD++ ++ +L + N
Sbjct: 359 TKTMLEDQL-EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM 417
Query: 964 LQK-----------SIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 1012
QK +E ++ +E S+ E + +L LE + ++ +
Sbjct: 418 AQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
Query: 1013 ELKARYE------------RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1060
EL+ + ++ +K EIL+N ++ + L+ + + L++E
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN---EIVQEKQSLQNCQNLSKDLMKE 534
Query: 1061 LEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL 1120
+L K + + + +E ++I+EQ + +T++SL Q +A+ + + D KEN +
Sbjct: 535 KAQLEKTIETLR--ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVK-DIEKENKI 591
Query: 1121 KNVEELNKSKELLTVENQKMEEFRKEIETLK---QAAAQKSQQLSALQEENVKLAEELGR 1177
+ S +L +E +K + +KE+E K + A + +L L++EN L +++
Sbjct: 592 LHESIKETSSKLSKIEFEK-RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650
Query: 1178 SRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAE 1237
+ + LE+E S L + ++KK F K+ + SL+K S + D E
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSF-KNLTFQLESLEKENS-------QLDEE 702
Query: 1238 LEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNT 1297
+LR V L+ + L + LES+K +L+ ++ L+ K+ +R L S
Sbjct: 703 NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER-LEVSYQGL 761
Query: 1298 DTQADEDERAQES---QIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSD 1354
D + ++ E+ +I L S + DL+ +NQ L+ +E + ++ + N +
Sbjct: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821
Query: 1355 DQEKQSKK 1362
+ Q +K
Sbjct: 822 QETSQLEK 829
Score = 89.0 bits (219), Expect = 3e-17
Identities = 203/1034 (19%), Positives = 418/1034 (40%), Gaps = 152/1034 (14%)
Query: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
LQ+ L+ + I+QL E +L+ E+ T + + +EL ++ +Q LE E K +
Sbjct: 768 LQKTLENSNKKIQQL--ESELQDLEMENQT--LQKNLEELKISSKRLEQ--LEKENKSLE 821
Query: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKL----------E 462
T D++++E N+ ++ +++D +EE ++ G+LE + K
Sbjct: 822 QETSQLEKDKKQLEKENKRLRQQAEIKDTT--LEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 463 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAEL---R 519
R+KELE+ +A + L R VSEK + ++ DL E+ ++ +
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 520 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQ--KEI 577
RL ++ + D L + S+L++ LE+ L+E ++ Q K +
Sbjct: 940 ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV 999
Query: 578 KALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKG 637
K Y A ++ E ++S + ++N W+ + + + + L + +
Sbjct: 1000 KKNYEALKQRQDEERMVQSSPPISGEDNK-----WERESQETTRELLKVKDRL-IEVERN 1053
Query: 638 LGTETAEFAELKTQIEKMR----------LDYQHEIENLQNQQDSERAAHAK-EMEALRA 686
T AE LKTQ++++ L Q + +LQ Q + + +AK ++E
Sbjct: 1054 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL 1113
Query: 687 KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE-LEVLQAKCNEQT 745
+N+ I+ + E++ +++ + L L ++ IK E LE+L + +
Sbjct: 1114 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY 1173
Query: 746 KVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK----N 801
+ + + LK+ + +L+ + + +++ K + QLE EK +K +E EK N
Sbjct: 1174 ESLISKHGTLKSAHK---NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK-VEQEKMLLEN 1229
Query: 802 AESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQR 861
++ ++L G +L + L + ++V +T K L+ L
Sbjct: 1230 KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL---------------- 1273
Query: 862 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 921
+ +S LE+ R +EA+F + E+ +QL KL N
Sbjct: 1274 -----------------LNNSKLEQTR-----LEAEFSKLKEQYQQLDITSTKLNNQCEL 1311
Query: 922 IMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE 981
+ ++ G+ + + D+++ T +N + L++++E + + +Q
Sbjct: 1312 LSQLKGNLEEENRHLLDQIQ-------------TLMLQNRTLLEQNMESKDLFHVEQRQY 1358
Query: 982 AAKKHE--EEKKELERKLSDLEK----------------KMETSHNQCQELKARYERATS 1023
K +E +K++LE K+ D K KM +++ +++ +
Sbjct: 1359 IDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLT 1418
Query: 1024 ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQI 1083
T T+ + LQ D++D + S L++ + L + K++ A +
Sbjct: 1419 LTPTRSDSSEGFLQLPHQDSQD----SSSVGSNSLEDGQTLGTK----KSSMVALKRLPF 1470
Query: 1084 MEQMTKEKTETLASLEDTKQTNAKLQNEL----DTLKENNLKNVEELNKSKELLTVENQK 1139
+ K+K + A + N +Q+ + T NL+ ++++ K +
Sbjct: 1471 LRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMA 1530
Query: 1140 MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL---GRSRDEVTSHQ-------KLE 1189
T+ +A +S+QL + ++ E++ G S D T + L+
Sbjct: 1531 FSTTAINFSTVNSSAGFRSKQL--VNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASLD 1588
Query: 1190 EERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLR 1249
R+ +N E K A ++ Q S +LL + +A + + L+
Sbjct: 1589 SGRTSTSNSNNNASLHEVK--AGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLK 1646
Query: 1250 GENASAKSL-HSVVQTLESDKVKLELKVKNLEL----QLKENKRQLSS---SSGNTDTQA 1301
+ S+ L H + +TLES K++ E+ Q E +L+S S + +
Sbjct: 1647 RQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLL 1706
Query: 1302 DEDERAQESQIDFL 1315
DE ++ DFL
Sbjct: 1707 DEVMKSLSVSSDFL 1720
Score = 62.8 bits (151), Expect = 2e-09
Identities = 120/518 (23%), Positives = 205/518 (39%), Gaps = 104/518 (20%)
Query: 825 QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL 884
QE L ++ + +L L I K F+E E V + QK+E+F +
Sbjct: 91 QETLQQL--IMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEF------I 142
Query: 885 EKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK- 943
E+++ D + K +E + + E+ MS ++ L K N L LK
Sbjct: 143 ERIQG--LDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLK-NMALHLKR 199
Query: 944 ---ERDVE-ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 999
ERD E ++L++ + FL + + A+ K E ++ L +L+D
Sbjct: 200 LIDERDEHSETIIELSEERDGLHFLPHA----SSSAQSPCGSPGMKRTESRQHLSVELAD 255
Query: 1000 LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ 1059
KA+ R E + K E++L Q+ L E +LK ++EN LL
Sbjct: 256 A--------------KAKIRRLRQELEEKTEQLLDCKQE-LEQMEIELKRLQQENMNLLS 300
Query: 1060 ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENN 1119
+ R D+ A + E A+++ KL++E+ KE
Sbjct: 301 DARSARMYRDELDALR--EKAVRV----------------------DKLESEVSRYKER- 335
Query: 1120 LKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSR 1179
L ++E E L +NQ + E + +E + +S +L L++EN++L +L
Sbjct: 336 LHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME 395
Query: 1180 DEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1239
E +K EE + N LEM +++S D + IS TS L
Sbjct: 396 MERDMDRKKIEEL-MEENMTLEMAQKQSM---DESLHLGWELEQISRTSEL--------- 442
Query: 1240 KLRNEVTVLRGENASAKSL-HSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTD 1298
A KSL H V + S +KLE++ ++L ++E + + S GN
Sbjct: 443 -----------SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA- 490
Query: 1299 TQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1336
S I+ ++++NQ L KVE++
Sbjct: 491 ------------------SKILKMEKENQRLSKKVEIL 510
Score = 50.8 bits (120), Expect = 9e-06
Identities = 76/380 (20%), Positives = 152/380 (40%), Gaps = 58/380 (15%)
Query: 1005 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1064
E +HNQ ++ T ++ E +L+N+ L +L R+E+S + EL E
Sbjct: 162 EVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHL----KRLIDERDEHSETIIELSEE 217
Query: 1065 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1124
R D + + + S K+T ++ +
Sbjct: 218 R-------------DGLHFLPHASSSAQSPCGS-PGMKRTESRQHLSV------------ 251
Query: 1125 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL----------AEE 1174
EL +K + Q++EE +++ KQ Q +L LQ+EN+ L +E
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
Query: 1175 LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1234
L R++ KLE E S +L +++ +++ +++ E+ L ++ ++ L
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKAR-VEELKEDNQVLLETKTMLEDQLEGT 370
Query: 1235 DAELEKLRNEVTVLRGENASAKS-LHSVVQTLESDKVKL-ELKVKNLELQLKENKR---- 1288
A +KL L EN K+ LH + + D+ K+ EL +N+ L++ + +
Sbjct: 371 RARSDKLHE----LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426
Query: 1289 -----QLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEA--AL 1341
+L S ++ + + +S ++ L+ +NQ L VE + ++
Sbjct: 427 LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486
Query: 1342 NGNGDDLNNYDSDDQEKQSK 1361
GN + + ++Q K
Sbjct: 487 EGNASKILKMEKENQRLSKK 506
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 169 bits (428), Expect = 2e-41
Identities = 198/968 (20%), Positives = 430/968 (44%), Gaps = 126/968 (13%)
Query: 289 AKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKIS 348
A+A+ ++ T S+ + + L + + + S + L+ T +I+
Sbjct: 2005 AEAEVKEKTELLQTLSSDV-----SELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIA 2059
Query: 349 GTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEA 408
+E L ++ + ++ L+E D E+ V+KA + E AL + V +L
Sbjct: 2060 QLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Query: 409 KMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKE 468
+++LR +EA +++++ + +L+E +R+ + L+ +VE +LE + ++ E
Sbjct: 2120 GIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE-------NLERELQM-----SE 2167
Query: 469 LEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPA 528
Q L+ + K + E T++ ++ ++ EL DL E L ++++ +
Sbjct: 2168 ENQELVILDAENSKAEVETLKTQIEEMARSLKVFEL--DLVTLRSEKENLTKQIQEKQ-- 2223
Query: 529 GDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLS 588
G + LL SL E+ E + E + E + + + + AL E +
Sbjct: 2224 GQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 2283
Query: 589 KENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAE- 647
+SL +E ++ + + L +++LE +++LK E+ A+
Sbjct: 2284 ATEQSLDPPIEEEHQLRNSIEKL-RARLEADEKKQLCVLQQLK---------ESEHHADL 2333
Query: 648 LKTQIEKMRLDYQHEIENLQNQQDSERAAHAK-EMEALRAK---LMKVIKEKENSLEAIR 703
LK ++E L+ + EI + + A ++K E+E L+AK + + ++ E + IR
Sbjct: 2334 LKGRVE--NLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIR 2391
Query: 704 SKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLL 763
S E E+ N+LQ+ + ++ ELE++ + +F + L+ E++ +
Sbjct: 2392 S-----------EKENLTNELQKEQERISELEIINS----------SFENILQEKEQEKV 2430
Query: 764 DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTN 823
+ + + M+ L+ QL+ +++ L ++ A +K +++ +++ EL+
Sbjct: 2431 QM------KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQ 2484
Query: 824 LQENLSEVSQVKETLE-------KELQILKEKFAEASEEAVSVQRSMQ---ETVNKLHQK 873
L + L E L+ +E++ K+K + EE ++ +Q + V+KL Q
Sbjct: 2485 LLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQV 2544
Query: 874 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 933
E + + +LR ++E K Q++++K D E+++ S N
Sbjct: 2545 EGEHQLWKEQNLELRNLTVELEQKI--------QVLQSKNASLQDTLEVLQSSYKN---- 2592
Query: 934 TKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA---------- 983
+ +EL L + D K+ K + LQ+ + +M K + Q+E +
Sbjct: 2593 --LENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGEL 2650
Query: 984 -------KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNL 1036
K +++ KEL + S+L+K ++ H E + + +E + + E +
Sbjct: 2651 QLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKH 2710
Query: 1037 QKTLLDT----EDKLKGAREENSGLLQELEELRKQADKAKAAQ-----TAEDAMQIMEQM 1087
Q LLDT E +++ RE+ + + L + + D K+++ + + QI+E++
Sbjct: 2711 QALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEEL 2770
Query: 1088 TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKE- 1146
K K + L + K+ N + Q ++ L +K+ ++L + KE+L E +++ +++
Sbjct: 2771 KKTKMDNLKYVNQLKKENERAQGKMKLL----IKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
Query: 1147 -----IETLKQAAAQKSQQLSALQEENVKLAEE-LGRSRDEVTSHQKLEEERSVLNNQLL 1200
++T + ++L EE K A+E L + + SH+KLE+ + +L Q+
Sbjct: 2827 KTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVA 2886
Query: 1201 EMKKRESK 1208
+ ++SK
Sbjct: 2887 HLCSQQSK 2894
Score = 160 bits (404), Expect = 1e-38
Identities = 244/1081 (22%), Positives = 476/1081 (44%), Gaps = 181/1081 (16%)
Query: 405 ELEAKMD----QLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTK 460
EL++K+ QL T +EA +EL + E K++ DL ++E S +L + +
Sbjct: 1806 ELDSKLHLQEVQLMTKIEAC----IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE 1861
Query: 461 LEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSE--KSRIMELEKDLALRVQEVAEL 518
+LE ADK RE VA V++ K R +++E +L+ E A +
Sbjct: 1862 TSEGLNSDLEMH-------ADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASI 1914
Query: 519 RRR---LESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQK 575
LE++ V L++ + ++K+ V + +TS + +T K
Sbjct: 1915 EHEALYLEADLEV--VQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSK 1972
Query: 576 EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFS 635
+ AL +EK+ ++ + L+S E I + E + + ++ L S
Sbjct: 1973 KTTALDQLSEKMKEKTQELESH----QSECLHCIQV----AEAEVKEKTELLQTLSSDVS 2024
Query: 636 KGLGTETAEFAELKTQIEKMRLDYQH------EIENLQNQQDSERAAHAKEMEALRAKLM 689
+ L +T L+ +++ + D Q E+EN Q + E+ KE E+L+A+L
Sbjct: 2025 ELLKDKT----HLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLS 2080
Query: 690 KVIKEKENSLEAIRSKL-DKAE--------DQHLVEMEDTLNKLQ---EAEIKVKELEVL 737
+ EK N +A+ + L +K E + + ++ + KL+ EA+ K K+L +
Sbjct: 2081 ESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEK-KQLHIA 2139
Query: 738 QA-----KCNEQTK-VIDNFTSQLKATEE--KLLDLDALRKASSEGKSEMKKLRQQLEAA 789
+ + N+ K ++N +L+ +EE +L+ LDA K+E++ L+ Q+E
Sbjct: 2140 EKLKERERENDSLKDKVENLERELQMSEENQELVILDA-----ENSKAEVETLKTQIEEM 2194
Query: 790 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS-----------QVKETL 838
+ +K E++ S+ ++T+++Q ++ +L+ L + LS Q+KE
Sbjct: 2195 ARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEES 2254
Query: 839 EKELQILKEKFAEASEEAVSV---QRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADME 895
+ +++L+ + E +E ++ Q M+ T L E+ + L + +EKLR L E
Sbjct: 2255 KTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADE 2314
Query: 896 AK-------FREKDEREEQLIKAKEKLENDIA------EIMKMSGDNS--------SQLT 934
K +E + + L E LE ++ E + +NS +++
Sbjct: 2315 KKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIE 2374
Query: 935 KMNDELRLKERDV-------EELQLKLTKANENASFLQ---KSIEDMTVKAEQSQQEAAK 984
M LR E DV E L +L K E S L+ S E++ + EQ + + +
Sbjct: 2375 GMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKE 2434
Query: 985 KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTE 1044
K + L+ +L +L +++ HN + KA+ + +S+ + E Q LQ L + +
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQG-LDEAK 2493
Query: 1045 DKLKGAREENSGLLQELEELRKQADK-----AKAAQTAEDAMQIMEQMTK---------- 1089
+ + +GL+QE+E+ +++ +K ++ +D Q++ ++++
Sbjct: 2494 NNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKE 2553
Query: 1090 -------------EKTETL----ASLEDT----KQTNAKLQNELDTLKENNLKNVEELNK 1128
+K + L ASL+DT + + L+NEL+ K + + VE++NK
Sbjct: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
Query: 1129 SKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL 1188
K E ++E+ + Q A+ ++LS E +LA EL +E+ S +
Sbjct: 2614 M-------TAKETELQREMHEMAQKTAELQEELSG---EKNRLAGELQLLLEEIKSSKDQ 2663
Query: 1189 EEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL------R 1242
+E ++ N+ E+KK KD E++ +++ I+ L E + + + L +
Sbjct: 2664 LKELTLENS---ELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQ 2720
Query: 1243 NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQAD 1302
EV + + L S + L S K++++L LK +K +L++S T +
Sbjct: 2721 YEVEI----QTYREKLTSKEECLSSQKLEIDL--------LKSSKEELNNSLKATTQILE 2768
Query: 1303 EDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKK 1362
E ++ + + ++N + + +R KMK+ + S L + L S Q Q K+
Sbjct: 2769 ELKKTKMDNLKYVNQLKKENERAQG--KMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
Query: 1363 K 1363
K
Sbjct: 2827 K 2827
Score = 148 bits (374), Expect = 3e-35
Identities = 243/1082 (22%), Positives = 471/1082 (43%), Gaps = 146/1082 (13%)
Query: 336 LTETSSRYARKISGTTALQEALKEKQ-QHIEQLLA----ERDLERAEVA--------KAT 382
L E + K+ Q +K K+ Q +EQLL+ E D R + K T
Sbjct: 1555 LCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLT 1614
Query: 383 SHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQ 442
S E+E +LA + +Q LELE R ++ D LL E+ +Q
Sbjct: 1615 SVTLEMESKLAAEKKQTEQLSLELEVA----RLQLQGLDLSSRSLLGIDTEDA-----IQ 1665
Query: 443 FRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELED-TRVATV------ 495
R E I+K T+ R + + + +K L ++E T V
Sbjct: 1666 GRNESCDISKEHTSETTE----RTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGEC 1721
Query: 496 -SEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMS-LSLLQEISSLQEKLEVTRT 553
E+S E + Q +E L + P V M L ++I +LQ +++ T
Sbjct: 1722 SGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN 1781
Query: 554 DHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLE----------HANK 603
++ R + +++ + E+ E+K L KL + L +K+E K
Sbjct: 1782 ENLRLLHVIEDR-DRKVESLLNEMKEL---DSKLHLQEVQLMTKIEACIELEKIVGELKK 1837
Query: 604 ENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ------IEKMRL 657
ENSD+ KLE HQ+ ++ +V S+GL ++ A+ ++ + K+
Sbjct: 1838 ENSDL----SEKLEYFSCDHQELLQ--RVETSEGLNSDLEMHADKSSREDIGDNVAKVND 1891
Query: 658 DYQH---EIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL 714
++ ++EN ++ SE+A+ E L A L +V++ ++ LE K ++ + + +
Sbjct: 1892 SWKERFLDVENELSRIRSEKASIEHEALYLEADL-EVVQTEKLCLE----KDNENKQKVI 1946
Query: 715 VEMEDTLNKLQEAEIKVK-ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK--- 770
V +E+ L+ + +++ EL+ + K T +D + ++K EK +L++ +
Sbjct: 1947 VCLEEELSVVTSERNQLRGELDTMSKK----TTALDQLSEKMK---EKTQELESHQSECL 1999
Query: 771 -ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS 829
++E+K+ + L+ + L +K K S+ ++ Q L L+ ++
Sbjct: 2000 HCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIA 2059
Query: 830 EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ-------ETVNKLHQKEEQFNMLSS 882
++++ KE L KE + L+ + +E+ E ++V ++++ E +L +E+ + L
Sbjct: 2060 QLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Query: 883 DLEKLRENLADMEAK---FREK-DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 938
+EKLR + E K EK ERE + K+K+EN E+ Q+++ N
Sbjct: 2120 GIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLEREL---------QMSEENQ 2170
Query: 939 ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 998
EL + + + + +++ K + ++ + +S++E K +EK + +LS
Sbjct: 2171 ELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEK---QGQLS 2227
Query: 999 DLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDT-------EDKLKGAR 1051
+L+K + + + +E + + E+KT E+LQN K L + ++ +K
Sbjct: 2228 ELDKLLSSFKSLLEEKEQAEIQIKEESKTA-VEMLQNQLKELNEAVAALCGDQEIMKATE 2286
Query: 1052 EENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNE 1111
+ ++E +LR +K +A A++ Q+ +++E A L + N L+ E
Sbjct: 2287 QSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVEN--LERE 2344
Query: 1112 LDTLK----------ENNLKNVEELNKSKELLTVENQKME----EFRKEIETLKQAAAQK 1157
L+ + EN+ VE L E +T + +E R E E L ++
Sbjct: 2345 LEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKE 2404
Query: 1158 SQQLSALQEENVKLAEEL-GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE 1216
+++S L+ N L + +++V +K +L QL E+ +R + D +
Sbjct: 2405 QERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEAC 2464
Query: 1217 KASLQKSISITSALLTEKDAELEKL---RNEVTVLRGENASAKSLHSVVQTLESDKVKLE 1273
KA Q S L EK L+ L +N VL+ S++ ++Q +E K KLE
Sbjct: 2465 KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQ------SSVNGLIQEVEDGKQKLE 2518
Query: 1274 LK---VKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLK 1330
K + L+ Q+++ ++ +S S Q + + + + Q L ++ V+L++K Q L+
Sbjct: 2519 KKDEEISRLKNQIQDQEQLVSKLS-----QVEGEHQLWKEQNLELRNLTVELEQKIQVLQ 2573
Query: 1331 MK 1332
K
Sbjct: 2574 SK 2575
Score = 145 bits (365), Expect = 4e-34
Identities = 245/1164 (21%), Positives = 473/1164 (40%), Gaps = 148/1164 (12%)
Query: 258 AGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLS 317
+G++Y + KY K + + KA + M + ++ S+
Sbjct: 160 SGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSW 219
Query: 318 SMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAER------ 371
S +SS RT + + S+ Y T + L+ ++ +
Sbjct: 220 QQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHL 279
Query: 372 -DLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQ 430
D +A+ + + + E+E L GH++ + K +L+ +E A KVEL+
Sbjct: 280 LDQLKAQNQELRNKINELELRL----QGHEKEMKGQVNKFQELQLQLEKA---KVELI-- 330
Query: 431 LEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIK--ELEQSLLFEKTKADKLQRELE 488
EK KV + + +E + T + + A K LEQ L K + L + +
Sbjct: 331 ---EKEKVLN---KCRDELV-----RTTAQYDQASTKYTALEQKL---KKLTEDLSCQRQ 376
Query: 489 DTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKL 548
+ A S + +I E EK+ QE ++R + M L QE+ +
Sbjct: 377 NAESARCSLEQKIKEKEKEF----QEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
Query: 549 EVTRTDHQREITSLKEHFGAR-EETHQKEIKALYTATEKLSKENESLKSKLEHANKENSD 607
V + + + +TS+K+ EE QK +A KENE L+ +E KEN+
Sbjct: 433 NVLQAELDK-LTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE-LRRSMEEMKKENN- 489
Query: 608 VIALWKSKLETAIASHQQAME----ELKVSFSKGLGTETAEFAE----LKTQIEKMRLDY 659
L KS S Q+A E E ++ K ++ FAE T E M D
Sbjct: 490 ---LLKSH------SEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDL 540
Query: 660 QHEIENLQNQQDSERAAHA-KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 718
Q +I +N E+ A ++E R ++K++E+ +E + KL K E + +
Sbjct: 541 QEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLS 600
Query: 719 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
K +E E +E + +E K++ S+ + + K+ L+ K E
Sbjct: 601 ALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHE 660
Query: 779 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838
+++ E ++L +E + S + E++ ++L LQ+ +E S K
Sbjct: 661 YN---ERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK-AEFSDQKH-- 714
Query: 839 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 898
+KE++ + K ++ + + ++ +Q N++ K+ + L ++ E LR+ L +A
Sbjct: 715 QKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774
Query: 899 REKDEREEQLIKAKEK--LENDIAEIMKMSGDNSSQLTKMNDEL-------RLKERDVEE 949
++ + L+ ++ + + A I+ G S+ ++ E + + V+
Sbjct: 775 VTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDS 834
Query: 950 LQLKLTKANENASFLQKSIEDMTV---KAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 1006
L+ L + S LQK E++ + E++ +A + H+ E +++S L++
Sbjct: 835 LEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSA 894
Query: 1007 SHNQCQELKARYERATSETKTKHEEI------LQNLQKTLLDTEDKLKGA---------- 1050
N E + E E + ++++ +Q L+K+ ED LK
Sbjct: 895 HQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLE 954
Query: 1051 REENSGLL----QELEELRKQ------------ADKAKAAQTAEDAMQIMEQMTKE---- 1090
++E S ++ +E+EEL ++ +K Q +E +++ K
Sbjct: 955 KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISEL 1014
Query: 1091 ----KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRK- 1145
K E L L+ ++T N + L + K +E N E L E + E RK
Sbjct: 1015 SDQYKQEKLILLQRCEETG----NAYEDLSQK-YKAAQEKNSKLECLLNECTSLCENRKN 1069
Query: 1146 EIETLKQAAAQKSQQ----LSALQEENVKLAEELGRS----RDEVTSHQK-LEEERSVLN 1196
E+E LK+A A++ Q+ L+ +E N L EL R E+T +Q + E L
Sbjct: 1070 ELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLK 1129
Query: 1197 NQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGEN---- 1252
+++ +K+ ++K K+ ++ ++ + + ++ E E +RN V E
Sbjct: 1130 QEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCN 1189
Query: 1253 -----------ASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQA 1301
S S ++ + LE+ ELK++ E + + + +L + G+ +T
Sbjct: 1190 FKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSN 1249
Query: 1302 DEDERAQESQIDFLNSVIVDLQRK 1325
+D ++QE I L +D + K
Sbjct: 1250 LQDMQSQE--ISGLKDCEIDAEEK 1271
Score = 134 bits (337), Expect = 6e-31
Identities = 217/1060 (20%), Positives = 452/1060 (42%), Gaps = 189/1060 (17%)
Query: 414 RTMVEAADREKVELLNQL-EEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQS 472
R +A + VE L L E ++ +E L+ ++E + I K + I+ELEQ
Sbjct: 1538 RKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK----------NKEIQELEQL 1587
Query: 473 LLFEKTKADKLQRE-LEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLE-SNKPAGD 530
L E+ + D L+++ L + S +E+E LA ++ +L LE +
Sbjct: 1588 LSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQG 1647
Query: 531 VDMSLSLL------QEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTAT 584
+D+S L I E ++++ +H E T + + + L
Sbjct: 1648 LDLSSRSLLGIDTEDAIQGRNESCDISK-EHTSETTERTPKHDVHQICDKDAQQDLNLDI 1706
Query: 585 EKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL------ 638
EK++ E ++K E + +++ D ++ E + + EL S L
Sbjct: 1707 EKIT-ETGAVKPTGECSGEQSPDTN--YEPPGEDKTQGSSECISELSFSGPNALVPMDFL 1763
Query: 639 ----GTETAEFAELKTQIEKMRL-----DYQHEIENLQNQ-QDSERAAHAKEMEALRA-- 686
+ +T E +RL D ++E+L N+ ++ + H +E++ +
Sbjct: 1764 GNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIE 1823
Query: 687 ---KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNE 743
+L K++ E + + KL+ H ++ L +++ +E +LE + A +
Sbjct: 1824 ACIELEKIVGELKKENSDLSEKLEYFSCDH----QELLQRVETSEGLNSDLE-MHADKSS 1878
Query: 744 QTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAE 803
+ + DN + +E+ LD++ +E+ ++R + + E + +LE +
Sbjct: 1879 REDIGDNVAKVNDSWKERFLDVE----------NELSRIRSEKASIEHEALYLEADLEVV 1928
Query: 804 SSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQI----------LKEKFAEAS 853
++ + ++ + ++ + L+E LS V+ + L EL L EK E +
Sbjct: 1929 QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKT 1988
Query: 854 EEAVSVQRS----MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI 909
+E S Q +Q ++ +K E LSSD+ +L ++ ++ K + ++ + L
Sbjct: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS 2048
Query: 910 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKAN----------- 958
K +LEN IA++ N E L ++ E LQ +L++++
Sbjct: 2049 LTKCELENQIAQL--------------NKEKELLVKESESLQARLSESDYEKLNVSKALE 2094
Query: 959 -----------------ENASFLQKSIEDMTVKAEQSQQ------EAAKKHEEEKKELER 995
E L++ IE + V+ E ++ E K+ E E L+
Sbjct: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD 2154
Query: 996 KLSDLEKKMETS--HNQCQELKARYERATSET-KTKHEEILQNLQ------KTLLDTEDK 1046
K+ +LE++++ S + + L A +A ET KT+ EE+ ++L+ TL ++
Sbjct: 2155 KVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKEN 2214
Query: 1047 LKGAREENSGLLQELEEL---------RKQADKAKAAQTAEDAMQIMEQMTKEKTETLAS 1097
L +E G L EL++L K+ + + + ++ A+++++ KE E +A+
Sbjct: 2215 LTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAA 2274
Query: 1098 LEDTKQTNAKLQNELD--TLKENNLKN-VEEL------NKSKELLTVENQKMEE-----F 1143
L ++ + LD +E+ L+N +E+L ++ K+L ++ K E
Sbjct: 2275 LCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLL 2334
Query: 1144 RKEIETLKQ--AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQ---------KLEEER 1192
+ +E L++ A+ +Q+ +AL+ EN K E +++ E + + E+
Sbjct: 2335 KGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEK 2394
Query: 1193 SVLNNQLLEMKKRESK----------FIKDADEEKASLQKSISITSALLTEKDAELEKLR 1242
L N+L + ++R S+ +++ ++EK +++ S +L +L++L
Sbjct: 2395 ENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEML---QTQLKELN 2451
Query: 1243 NEVTVLRGENASAK----SLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTD 1298
V L + + K +L S V+ LE +K +L ++ L+ + K N L SS
Sbjct: 2452 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQL---LQGLD-EAKNNYIVLQSSVNGLI 2507
Query: 1299 TQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
+ ++ ++ E + + I L+ + QD + V +S+
Sbjct: 2508 QEVEDGKQKLEKK----DEEISRLKNQIQDQEQLVSKLSQ 2543
Score = 133 bits (335), Expect = 1e-30
Identities = 215/995 (21%), Positives = 426/995 (42%), Gaps = 150/995 (15%)
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTK 460
Q + ELE ++D+L+ + + L L+++K+KVE+ + T+G T K
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEK--------TEG---TNLK 66
Query: 461 LEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRR 520
E+ R+ E+ +SL EKTK K+ EL+ ++ ++ +K + QE+ +
Sbjct: 67 RENQRLMEICESL--EKTK-QKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
Query: 521 RLE-SNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ----REITSLKEHFGAREETHQK 575
LE S + A D+SL+ ++ Q+ T Q + LKE + E ++
Sbjct: 124 ELERSQQAAQSADVSLN---PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR 180
Query: 576 ---EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKV 632
E+KAL + ++ + ++ +S V + + K + ++S+ Q ++
Sbjct: 181 LEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQ-RTPIRR 239
Query: 633 SFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVI 692
FS + E ++ ++ + D N +S +++A +L I
Sbjct: 240 DFSASYFSGEQEVTPSRSTLQIGKRD-----ANSSFFDNSSSPHLLDQLKAQNQELRNKI 294
Query: 693 KEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFT 752
E E L+ H EM+ +NK QE ++ +LE + + E+ KV++
Sbjct: 295 NELELRLQG-----------HEKEMKGQVNKFQELQL---QLEKAKVELIEKEKVLNKCR 340
Query: 753 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 812
+L T + D + + + E K +KKL + L +NAES++ S+ +
Sbjct: 341 DELVRTTAQ-YDQASTKYTALEQK--LKKLTEDLSCQ---------RQNAESARC-SLEQ 387
Query: 813 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 872
+++ +E QE LS + +TL++E +K + + ++A ++ +Q ++KL
Sbjct: 388 KIKEKE---KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTS 444
Query: 873 KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQ 932
++Q L ++LE+ ++ L E F+ +E +L ++ E+++ + +
Sbjct: 445 VKQQ---LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE------------NN 489
Query: 933 LTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE 992
L K + E + +E E +LK K N S Q E+M KA+ + QE
Sbjct: 490 LLKSHSEQKAREVCHLEAELKNIKQCLNQS--QNFAEEM--KAKNTSQET---------- 535
Query: 993 LERKLSDLEKKMETSHNQCQELKARYERATSETKTK-HEEILQNLQKTLLDTEDKLKGAR 1051
L DL++K+ N K + A E + +++L+ + + DKL
Sbjct: 536 ---MLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTE 592
Query: 1052 EENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNE 1111
+E+ LL LE +K+ ++ K +T + E + L +E K+ N
Sbjct: 593 KESKALLSALELKKKEYEELKEEKT------LFSCWKSENEKLLTQMESEKENLQSKINH 646
Query: 1112 LDT-LKENNLKN------VEELNKSKELLTVE----NQKMEEFRKEIETLKQAAAQKSQQ 1160
L+T LK +K+ V L +E L+VE + ++ E+ET K A + Q+
Sbjct: 647 LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
Query: 1161 LSALQEENVKLAEELGRSRDEVTSH-QKLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1219
+++ K E + ++T + LE + +L+N++++ + + +D E S
Sbjct: 707 AEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD----KDRCYQDLHAEYES 762
Query: 1220 LQKSI-SITSALLTEKDAELEKL--------RNEVTVLRGENASAKSLHSVVQTLESDK- 1269
L+ + S ++L+T +D + L + + GE S S S + LE+D+
Sbjct: 763 LRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECR-LEADQS 821
Query: 1270 ----VKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRK 1325
L+ +V +LE L+ K+ N+D Q +E +V ++ +
Sbjct: 822 PKNSAILQNRVDSLEFSLESQKQM------NSDLQKQCEE-------------LVQIKGE 862
Query: 1326 NQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQS 1360
++ MK E M ++ + ++ D Q+
Sbjct: 863 IEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQN 897
Score = 127 bits (319), Expect = 8e-29
Identities = 213/1056 (20%), Positives = 433/1056 (41%), Gaps = 184/1056 (17%)
Query: 336 LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALA 395
L T+++Y + + TAL++ LK+ E L +R + AE A+ + +EQ++
Sbjct: 343 LVRTTAQYDQASTKYTALEQKLKKLT---EDLSCQR--QNAESARCS-----LEQKI--- 389
Query: 396 RDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL 455
++ + EL + +T+ + + K L +L++ K LQ +++ + K L
Sbjct: 390 KEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449
Query: 456 ETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEV 515
E + ++ EQ+ + K ++L+R +E+ + KS + +++ E+
Sbjct: 450 ENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL 509
Query: 516 AELRRRLESNKPAGDVDMSLSLLQE--ISSLQEK--------------LEVTRTDHQREI 559
+++ L ++ + + + QE + LQEK L V + QR+
Sbjct: 510 KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569
Query: 560 TS--LK------EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIAL 611
+ LK E + +KE KAL +A E KE E LK E + +
Sbjct: 570 SQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELK--------EEKTLFSC 621
Query: 612 WKSKLETAIASHQQAMEELKVSFSK---GLGTETAEFAELKTQIEKMRLDYQH---EIEN 665
WKS+ E + + E L+ + L T+ + E ++ + +D ++ EI N
Sbjct: 622 WKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRN 681
Query: 666 LQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ 725
L N DS+ E+E + M+ ++ K + ++ +H E+E+ K
Sbjct: 682 LHNVLDSKSV----EVETQKLAYME-----------LQQKAEFSDQKHQKEIENMCLKTS 726
Query: 726 EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL----DALRKASSEGKSEMKK 781
+ +V++LE + + D L A E L DL DA + + + +
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA 786
Query: 782 LRQQLEA---------------AEKQIKHLEIEKNAESS-----KASSITRELQGRELKL 821
QQ +E+ LE +++ ++S + S+ L+ ++
Sbjct: 787 FDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMN 846
Query: 822 TNLQENLSEVSQVKETLEKELQILKE-----------KFAEASEEAVSVQRSMQETVNKL 870
++LQ+ E+ Q+K +E+ L ++ + ++ E+ + Q + ET++ L
Sbjct: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSAL 906
Query: 871 HQKEEQFNMLSSDLEKLRENLADMEAK--FREKDEREEQLIKAKEKLEN-DIAEIMKMSG 927
KE++ +L+ +E + + +++ E +E QL+ LE +++ I+ ++
Sbjct: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966
Query: 928 DNSSQLTKMNDELRLKERDVEELQLKLTKANEN-ASFLQKSIEDMTVKAEQSQQEAA--- 983
+LT+ N L+ + + ++ L + +E+ A+++ + + ++ ++Q +QE
Sbjct: 967 REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
Query: 984 -----------------KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETK 1026
K +E+ +LE L++ E N+ ++LK + + E
Sbjct: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFL 1086
Query: 1027 TK---HEEILQNLQKTLLDTEDKLKGAREENSG--------------------------- 1056
TK EE QNL L + L+ +N
Sbjct: 1087 TKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEV 1146
Query: 1057 --LLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT 1114
LLQE E+L K Q E + + KE+ + Q N K Q +L+
Sbjct: 1147 NDLLQENEQLMKVMKTKHECQNLES--EPIRNSVKERE------SERNQCNFKPQMDLE- 1197
Query: 1115 LKENNLKN-------VEELNKSKELLTVENQKMEE-FRKEIETLK------QAAAQKSQQ 1160
+KE +L + +E + ++KEL E++K +E + E++T++ +SQ+
Sbjct: 1198 VKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQE 1257
Query: 1161 LSALQEENVKLAEELGRSRDEVTSHQK----LEEERSVLNNQLLEMKKRESKFIKDADEE 1216
+S L++ + E+ E+++ Q L+ N+L E++K + E
Sbjct: 1258 ISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYEL 1317
Query: 1217 KASLQKSISITSALLTEKDAELEKLRNEVTVLRGEN 1252
L S S + E+ KL NEV +L ++
Sbjct: 1318 VTELNDSRSECITATRKMAEEVGKLLNEVKILNDDS 1353
Score = 64.3 bits (155), Expect = 8e-10
Identities = 99/528 (18%), Positives = 220/528 (41%), Gaps = 48/528 (9%)
Query: 867 VNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS 926
+ K+ + E Q + L + ++ + L +EA +++ ++ E L+ + +M++
Sbjct: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
Query: 927 GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 986
K++ EL++KE V + +L + L++ ++ + E+SQQ A
Sbjct: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
Query: 987 EE-EKKELERKL--SDLEKKMETSHNQCQELKARYERATSETKTKHEEI--------LQN 1035
+K+ + L S ++ ++LK +Y + E K E+ Q
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196
Query: 1036 LQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETL 1095
L + ++ D + + Q+ + + ++ D +E T +
Sbjct: 197 LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSR 256
Query: 1096 ASLEDTKQ-------TNAKLQNELDTLKENNLKNVEELNK--------SKELLTVENQKM 1140
++L+ K+ N+ + LD LK N + ++N+ KE+ N K
Sbjct: 257 STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVN-KF 315
Query: 1141 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS-HQKLEEERSVLNNQL 1199
+E + ++E K +K + L+ ++E V+ + ++ + T+ QKL++ L+ Q
Sbjct: 316 QELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQR 375
Query: 1200 LEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLH 1259
+ + E++ Q+ +S D E +++ +T E AK++H
Sbjct: 376 QNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLT---QELQQAKNMH 432
Query: 1260 SVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI 1319
+V L+++ KL + LE L+E K++L +A++ +A + + + L +
Sbjct: 433 NV---LQAELDKLTSVKQQLENNLEEFKQKL--------CRAEQAFQASQIKENELRRSM 481
Query: 1320 VDLQRKNQDLKMKVEMMS------EAALNGNGDDLNNYDSDDQEKQSK 1361
+++++N LK E + EA L LN + +E ++K
Sbjct: 482 EEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAK 529
Score = 35.0 bits (79), Expect = 0.52
Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 10/130 (7%)
Query: 1188 LEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTV 1247
LEE + L + L+ + + +EK Q + A L ++ ++E + E T
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
Query: 1248 LRGENASAKSLHSVVQTLESDKVKL--ELKVKNLEL-----QLKENKRQLSSSSGNTDTQ 1300
L+ EN + L + ++LE K K+ EL+VK ++ QL K+Q+
Sbjct: 65 LKREN---QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRC 121
Query: 1301 ADEDERAQES 1310
E ER+Q++
Sbjct: 122 KSELERSQQA 131
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.122 0.316
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,422,551
Number of Sequences: 37866
Number of extensions: 2226449
Number of successful extensions: 43025
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 775
Number of HSP's successfully gapped in prelim test: 1696
Number of HSP's that attempted gapping in prelim test: 12280
Number of HSP's gapped (non-prelim): 12334
length of query: 1427
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1312
effective length of database: 13,892,928
effective search space: 18227521536
effective search space used: 18227521536
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.