Search of human proteins with 4506737

Search of human proteins with 4506737

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1
[Homo sapiens]
         (525 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho...  1071   0.0  
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H...   669   0.0  
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   378   e-105
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   377   e-104
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...   377   e-104
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   375   e-104
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   375   e-104
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   372   e-103
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b...   353   2e-97
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a...   353   2e-97
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is...   336   4e-92
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso...   336   4e-92
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   308   8e-84
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   308   8e-84
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   308   8e-84
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   308   8e-84
gi|4502023 AKT2 kinase [Homo sapiens]                                 306   4e-83
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   299   5e-81
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   299   5e-81
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   298   8e-81
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   298   8e-81
gi|62241015 AKT1 kinase [Homo sapiens]                                297   2e-80
gi|62241013 AKT1 kinase [Homo sapiens]                                297   2e-80
gi|62241011 AKT1 kinase [Homo sapiens]                                297   2e-80
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       294   2e-79
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      294   2e-79
gi|28557781 protein kinase C, eta [Homo sapiens]                      279   5e-75
gi|4506067 protein kinase C, alpha [Homo sapiens]                     278   1e-74
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           274   2e-73
gi|5453974 protein kinase N2 [Homo sapiens]                           273   2e-73

>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
           sapiens]
          Length = 525

 Score = 1071 bits (2769), Expect = 0.0
 Identities = 525/525 (100%), Positives = 525/525 (100%)

Query: 1   MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG 60
           MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
Sbjct: 1   MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG 60

Query: 61  PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF 120
           PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
Sbjct: 61  PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF 120

Query: 121 AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL 180
           AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
Sbjct: 121 AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL 180

Query: 181 FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC 240
           FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
Sbjct: 181 FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC 240

Query: 241 KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK 300
           KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
Sbjct: 241 KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK 300

Query: 301 TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL 360
           TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
Sbjct: 301 TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL 360

Query: 361 LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE 420
           LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
Sbjct: 361 LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE 420

Query: 421 SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG 480
           SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
Sbjct: 421 SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG 480

Query: 481 IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL 525
           IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
Sbjct: 481 IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL 525


>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
           sapiens]
          Length = 482

 Score =  669 bits (1727), Expect = 0.0
 Identities = 340/490 (69%), Positives = 394/490 (80%), Gaps = 19/490 (3%)

Query: 24  MAGVFDIDLDQPEDAGSEDELE----EGGQLNESMDHGGVGPYELGMEHCEKFEISETSV 79
           MA VFD+DL+  E +  E E E    +   L E +   G+ P    + H E+ E++ETSV
Sbjct: 1   MAAVFDLDLETEEGSEGEGEPELSPADACPLAE-LRAAGLEP----VGHYEEVELTETSV 55

Query: 80  NRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAH 139
           N GPE+I P CFELLRVLGKGGYGKVFQVRKV G N GKI+AMKVL+KA IVRNAKDTAH
Sbjct: 56  NVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAH 115

Query: 140 TKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYL 199
           T+AERNILE VKHPFIV+L YAFQTGGKLYLILE LSGGELF  LEREGIF+EDTACFYL
Sbjct: 116 TRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYL 175

Query: 200 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 259
           AEI++ALGHLH +GIIYRDLKPENIML+ QGH+KLTDFGLCKESIH+G VTHTFCGTIEY
Sbjct: 176 AEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEY 235

Query: 260 MAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQE 319
           MAPEIL+RSGHNRAVDWWSLGALMYDMLTG+PPFT ENRKKT+DKI++ KL LPPYLT +
Sbjct: 236 MAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPD 295

Query: 320 ARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDV 379
           ARDL+KK LKRN + R+G GPGDA +VQ HPFFRH+NW++LLA +V+PPF+P LQSEEDV
Sbjct: 296 ARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDV 355

Query: 380 SQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFI 439
           SQFD++FTRQTPVDSPDD+ LSESANQ FLGFTYVAPSVL+S+KE FSF+PK+RSPRR  
Sbjct: 356 SQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLN 415

Query: 440 GSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIR 499
            SPR PVSP+KFSP +    G   S + P+ P E P     +  +        +APLPIR
Sbjct: 416 SSPRAPVSPLKFSPFE----GFRPSPSLPE-PTELP-----LPPLLPPPPPSTTAPLPIR 465

Query: 500 QPNSGPYKKQ 509
            P+     K+
Sbjct: 466 PPSGTKKSKR 475


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  378 bits (970), Expect = e-105
 Identities = 196/393 (49%), Positives = 265/393 (67%), Gaps = 22/393 (5%)

Query: 58  GVGPYELGMEHCEKFEISETS-VNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANT 116
           G GP     E   K EIS T  V  G EK  P  FELL+VLG+G +GKVF VRKVT  ++
Sbjct: 38  GSGPQRDSDEGVLK-EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDS 96

Query: 117 GKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLS 176
           G ++AMKVLKKA +    +D   TK ER+IL +V HPF+V L YAFQT GKLYLIL++L 
Sbjct: 97  GHLYAMKVLKKATL--KVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLR 154

Query: 177 GGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTD 236
           GG+LF +L +E +F E+   FYLAE+++ L HLH  GIIYRDLKPENI+L+ +GH+KLTD
Sbjct: 155 GGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTD 214

Query: 237 FGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGE 296
           FGL KE+I      ++FCGT+EYMAPE++ R GH+ + DWWS G LM++MLTG+ PF G+
Sbjct: 215 FGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGK 274

Query: 297 NRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHIN 356
           +RK+T+  ILK KL +P +L+ EA+ LL+ L KRN A+RLG+GP  A E++ H F+  I+
Sbjct: 275 DRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTID 334

Query: 357 WEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAP 416
           W +L  R+++PPFKP +   +D   FD++FT +TP DSP     S  A+Q+F GF++VA 
Sbjct: 335 WNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPP-SAGAHQLFRGFSFVAT 393

Query: 417 SVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPV 449
            ++E                   G PR P +P+
Sbjct: 394 GLMED-----------------DGKPRAPQAPL 409



 Score =  115 bits (288), Expect = 1e-25
 Identities = 78/262 (29%), Positives = 133/262 (50%), Gaps = 23/262 (8%)

Query: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160
           G G   + ++     T   +A+KV+ K+   R+  +         +L   +HP I+ L  
Sbjct: 434 GVGSYSECKRCVHKATNMEYAVKVIDKSK--RDPSEEIEI-----LLRYGQHPNIITLKD 486

Query: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220
            +  G  +YL+ E + GGEL  ++ R+  F E  A F L  I   + +LH +G+++RDLK
Sbjct: 487 VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLK 546

Query: 221 PENIM-LNHQGH---VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDW 276
           P NI+ ++  G+   +++ DFG  K+   +  +  T C T  ++APE+L R G++   D 
Sbjct: 547 PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI 606

Query: 277 WSLGALMYDMLTGAPPFT---GENRKKTIDKILKCKLNLP----PYLTQEARDLLKKLLK 329
           WSLG L+Y ML G  PF     +  ++ + +I   K  L       +++ A+DL+ K+L 
Sbjct: 607 WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH 666

Query: 330 RNAASRLGAGPGDAGEVQAHPF 351
            +   RL      A +V  HP+
Sbjct: 667 VDPHQRL-----TAKQVLQHPW 683


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform a [Homo sapiens]
          Length = 735

 Score =  377 bits (969), Expect = e-104
 Identities = 191/378 (50%), Positives = 260/378 (68%), Gaps = 21/378 (5%)

Query: 73  EISETS-VNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIV 131
           EIS T  V  G EK  P  FELL+VLG+G +GKVF VRKVT  ++G ++AMKVLKKA + 
Sbjct: 43  EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL- 101

Query: 132 RNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 191
              +D   TK ER+IL +V HPF+V L YAFQT GKLYLIL++L GG+LF +L +E +F 
Sbjct: 102 -KVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFT 160

Query: 192 EDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTH 251
           E+   FYLAE+++ L HLH  GIIYRDLKPENI+L+ +GH+KLTDFGL KE+I      +
Sbjct: 161 EEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAY 220

Query: 252 TFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLN 311
           +FCGT+EYMAPE++ R GH+ + DWWS G LM++MLTG+ PF G++RK+T+  ILK KL 
Sbjct: 221 SFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG 280

Query: 312 LPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 371
           +P +L+ EA+ LL+ L KRN A+RLG+GP  A E++ H F+  I+W +L  R+++PPFKP
Sbjct: 281 MPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 340

Query: 372 LLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPK 431
            +   +D   FD++FT +TP DSP     S  A+Q+F GF++VA  ++E           
Sbjct: 341 AVAQPDDTFYFDTEFTSRTPKDSPGIPP-SAGAHQLFRGFSFVATGLMED---------- 389

Query: 432 IRSPRRFIGSPRTPVSPV 449
                   G PR P +P+
Sbjct: 390 -------DGKPRAPQAPL 400



 Score =  115 bits (288), Expect = 1e-25
 Identities = 78/262 (29%), Positives = 133/262 (50%), Gaps = 23/262 (8%)

Query: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160
           G G   + ++     T   +A+KV+ K+   R+  +         +L   +HP I+ L  
Sbjct: 425 GVGSYSECKRCVHKATNMEYAVKVIDKSK--RDPSEEIEI-----LLRYGQHPNIITLKD 477

Query: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220
            +  G  +YL+ E + GGEL  ++ R+  F E  A F L  I   + +LH +G+++RDLK
Sbjct: 478 VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLK 537

Query: 221 PENIM-LNHQGH---VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDW 276
           P NI+ ++  G+   +++ DFG  K+   +  +  T C T  ++APE+L R G++   D 
Sbjct: 538 PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI 597

Query: 277 WSLGALMYDMLTGAPPFT---GENRKKTIDKILKCKLNLP----PYLTQEARDLLKKLLK 329
           WSLG L+Y ML G  PF     +  ++ + +I   K  L       +++ A+DL+ K+L 
Sbjct: 598 WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH 657

Query: 330 RNAASRLGAGPGDAGEVQAHPF 351
            +   RL      A +V  HP+
Sbjct: 658 VDPHQRL-----TAKQVLQHPW 674


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
           sapiens]
          Length = 740

 Score =  377 bits (969), Expect = e-104
 Identities = 195/376 (51%), Positives = 259/376 (68%), Gaps = 8/376 (2%)

Query: 42  DELEEGGQL-NESMDHGGVGPYELGMEHCEKFEISETS-VNRGPEKIRPECFELLRVLGK 99
           D  E G Q+ +E M    + P     E     EI+ T  V  G EK  P  FELL+VLG+
Sbjct: 20  DSAENGQQIMDEPMGEEEINPQT---EEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQ 76

Query: 100 GGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLI 159
           G +GKVF V+K++G++  +++AMKVLKKA +    +D   TK ER+IL EV HPFIV L 
Sbjct: 77  GSFGKVFLVKKISGSDARQLYAMKVLKKATL--KVRDRVRTKMERDILVEVNHPFIVKLH 134

Query: 160 YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDL 219
           YAFQT GKLYLIL++L GG+LF +L +E +F E+   FYLAE+++AL HLH  GIIYRDL
Sbjct: 135 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDL 194

Query: 220 KPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSL 279
           KPENI+L+ +GH+KLTDFGL KESI      ++FCGT+EYMAPE++ R GH ++ DWWS 
Sbjct: 195 KPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSF 254

Query: 280 GALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAG 339
           G LM++MLTG  PF G++RK+T+  ILK KL +P +L+ EA+ LL+ L KRN A+RLGAG
Sbjct: 255 GVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAG 314

Query: 340 PGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDST 399
           P    E++ H FF  I+W +L  R++ PPFKP     ED   FD +FT +TP DSP    
Sbjct: 315 PDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPP 374

Query: 400 LSESANQVFLGFTYVA 415
            S +A+Q+F GF++VA
Sbjct: 375 -SANAHQLFRGFSFVA 389



 Score =  120 bits (302), Expect = 2e-27
 Identities = 93/324 (28%), Positives = 161/324 (49%), Gaps = 29/324 (8%)

Query: 91  FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150
           +E+   +G G Y      ++     T   FA+K++ K+      +D   T+    +L   
Sbjct: 422 YEVKEDIGVGSYSVC---KRCIHKATNMEFAVKIIDKSK-----RDP--TEEIEILLRYG 471

Query: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 210
           +HP I+ L   +  G  +Y++ E + GGEL  ++ R+  F E  A   L  I+  + +LH
Sbjct: 472 QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLH 531

Query: 211 QKGIIYRDLKPENIM-LNHQGH---VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 266
            +G+++RDLKP NI+ ++  G+   +++ DFG  K+   +  +  T C T  ++APE+L 
Sbjct: 532 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 591

Query: 267 RSGHNRAVDWWSLGALMYDMLTGAPPFTG---ENRKKTIDKILKCKLNLP----PYLTQE 319
           R G++ A D WSLG L+Y MLTG  PF     +  ++ + +I   K +L       ++  
Sbjct: 592 RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDT 651

Query: 320 ARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDV 379
           A+DL+ K+L  +   RL      A  V  HP+  H  W++L   ++     P L      
Sbjct: 652 AKDLVSKMLHVDPHQRL-----TAALVLRHPWIVH--WDQLPQYQLNRQDAPHLVKGAMA 704

Query: 380 SQFDSKFTRQTPVDSP-DDSTLSE 402
           + + +    Q+PV  P   STL++
Sbjct: 705 ATYSALNRNQSPVLEPVGRSTLAQ 728


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform b [Homo sapiens]
          Length = 741

 Score =  375 bits (964), Expect = e-104
 Identities = 184/347 (53%), Positives = 250/347 (72%), Gaps = 3/347 (0%)

Query: 79  VNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTA 138
           V  G EK  P  FELL+VLG+G YGKVF VRKV G++ G+++AMKVLKKA +    +D  
Sbjct: 55  VKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRV 112

Query: 139 HTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFY 198
            +K ER+IL EV HPFIV L YAFQT GKLYLIL++L GG+LF +L +E +F E+   FY
Sbjct: 113 RSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFY 172

Query: 199 LAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIE 258
           LAE+++AL HLH  GIIYRDLKPENI+L+ +GH+K+TDFGL KE+I      ++FCGTIE
Sbjct: 173 LAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIE 232

Query: 259 YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ 318
           YMAPE++ R GH ++ DWWS G LM++MLTG+ PF G++RK+T+  ILK KL +P +L+ 
Sbjct: 233 YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSG 292

Query: 319 EARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEED 378
           EA+ LL+ L KRN  +RLGAG     E++ HPFF  I+W  L  ++++PPFKP +   ED
Sbjct: 293 EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPED 352

Query: 379 VSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEK 425
              FD +FT +TP DSP     S +A+ +F GF++VA S+++   ++
Sbjct: 353 TFHFDPEFTARTPTDSPGVPP-SANAHHLFRGFSFVASSLIQEPSQQ 398



 Score =  112 bits (280), Expect = 8e-25
 Identities = 83/284 (29%), Positives = 138/284 (48%), Gaps = 30/284 (10%)

Query: 131 VRNAKDTAHT-----KAERNILEEVK-------HPFIVDLIYAFQTGGKLYLILEYLSGG 178
           V  A DT +      K++R+  EE++       HP I+ L   +  G  +YL++E + GG
Sbjct: 441 VHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGG 500

Query: 179 ELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG----HVKL 234
           EL  ++ R+  F E  A   L  I+  + +LH +G+++RDLKP NI+   +      +++
Sbjct: 501 ELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRV 560

Query: 235 TDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFT 294
            DFG  K+      +  T C T  ++APE+L R G++ A D WSLG L+Y ML G  PF 
Sbjct: 561 CDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFA 620

Query: 295 G---ENRKKTIDKILKCKLNLP----PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ 347
               +  ++ + +I   K  L       ++  A+D++ K+L  +   RL      A +V 
Sbjct: 621 NGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRL-----TAMQVL 675

Query: 348 AHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTP 391
            HP+   +N E L   ++      L++     + F    T Q P
Sbjct: 676 KHPWV--VNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAP 717


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform a [Homo sapiens]
          Length = 733

 Score =  375 bits (964), Expect = e-104
 Identities = 184/347 (53%), Positives = 250/347 (72%), Gaps = 3/347 (0%)

Query: 79  VNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTA 138
           V  G EK  P  FELL+VLG+G YGKVF VRKV G++ G+++AMKVLKKA +    +D  
Sbjct: 47  VKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRV 104

Query: 139 HTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFY 198
            +K ER+IL EV HPFIV L YAFQT GKLYLIL++L GG+LF +L +E +F E+   FY
Sbjct: 105 RSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFY 164

Query: 199 LAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIE 258
           LAE+++AL HLH  GIIYRDLKPENI+L+ +GH+K+TDFGL KE+I      ++FCGTIE
Sbjct: 165 LAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIE 224

Query: 259 YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ 318
           YMAPE++ R GH ++ DWWS G LM++MLTG+ PF G++RK+T+  ILK KL +P +L+ 
Sbjct: 225 YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSG 284

Query: 319 EARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEED 378
           EA+ LL+ L KRN  +RLGAG     E++ HPFF  I+W  L  ++++PPFKP +   ED
Sbjct: 285 EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPED 344

Query: 379 VSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEK 425
              FD +FT +TP DSP     S +A+ +F GF++VA S+++   ++
Sbjct: 345 TFHFDPEFTARTPTDSPGVPP-SANAHHLFRGFSFVASSLIQEPSQQ 390



 Score =  112 bits (280), Expect = 8e-25
 Identities = 83/284 (29%), Positives = 138/284 (48%), Gaps = 30/284 (10%)

Query: 131 VRNAKDTAHT-----KAERNILEEVK-------HPFIVDLIYAFQTGGKLYLILEYLSGG 178
           V  A DT +      K++R+  EE++       HP I+ L   +  G  +YL++E + GG
Sbjct: 433 VHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGG 492

Query: 179 ELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG----HVKL 234
           EL  ++ R+  F E  A   L  I+  + +LH +G+++RDLKP NI+   +      +++
Sbjct: 493 ELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRV 552

Query: 235 TDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFT 294
            DFG  K+      +  T C T  ++APE+L R G++ A D WSLG L+Y ML G  PF 
Sbjct: 553 CDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFA 612

Query: 295 G---ENRKKTIDKILKCKLNLP----PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ 347
               +  ++ + +I   K  L       ++  A+D++ K+L  +   RL      A +V 
Sbjct: 613 NGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRL-----TAMQVL 667

Query: 348 AHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTP 391
            HP+   +N E L   ++      L++     + F    T Q P
Sbjct: 668 KHPWV--VNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAP 709


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  372 bits (955), Expect = e-103
 Identities = 200/414 (48%), Positives = 272/414 (65%), Gaps = 17/414 (4%)

Query: 10  FYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHC 69
           F P  +  DRE E  +G       +       DE  E G+ +   D G V   E+ + H 
Sbjct: 4   FAPQDEPWDREMEVFSGG-GASSGEVNGLKMVDEPMEEGEADSCHDEGVVK--EIPITH- 59

Query: 70  EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAM 129
                    V  G EK  P  FELL+VLG+G +GKVF VRK TG + G+++AMKVLKKA 
Sbjct: 60  --------HVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKAS 111

Query: 130 IVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI 189
           +    +D   TK ER+IL EV HPFIV L YAFQT GKLYLIL++L GG++F +L +E +
Sbjct: 112 L--KVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVL 169

Query: 190 FMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTV 249
           F E+   FYLAE+++AL HLHQ GI+YRDLKPENI+L+  GH+KLTDFGL KES+     
Sbjct: 170 FTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKK 229

Query: 250 THTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK 309
            ++FCGT+EYMAPE++ R GH+++ DWWS G LM++MLTG  PF G++R +T++ ILK K
Sbjct: 230 AYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAK 289

Query: 310 LNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPF 369
           L +P +L+ EA+ LL+ L KRN A+RLG+      E++ H FF +I+W++L  R+V+PPF
Sbjct: 290 LGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPF 347

Query: 370 KPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVK 423
           KP     +D   FD +FT +TP DSP     S +A+Q+F GF++VA S+ E  K
Sbjct: 348 KPASGKPDDTFCFDPEFTAKTPKDSP-GLPASANAHQLFKGFSFVATSIAEEYK 400



 Score =  112 bits (279), Expect = 1e-24
 Identities = 77/261 (29%), Positives = 130/261 (49%), Gaps = 21/261 (8%)

Query: 89  ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 148
           E +EL   +G G Y      ++   A T   FA+K++ K+   R+  +         ++ 
Sbjct: 424 EVYELKEDIGVGSYSVC---KRCIHATTNMEFAVKIIDKSK--RDPSEEIEI-----LMR 473

Query: 149 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH 208
             +HP I+ L   F  G  +YL+ + + GGEL  ++ ++  F E  A   L  IS  + +
Sbjct: 474 YGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDY 533

Query: 209 LHQKGIIYRDLKPENIMLNHQG----HVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI 264
           LH +G+++RDLKP NI+   +      +++ DFG  K+   +  +  T C T  ++APE+
Sbjct: 534 LHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEV 593

Query: 265 LMRSGHNRAVDWWSLGALMYDMLTGAPPFT---GENRKKTIDKILKCKLNLP----PYLT 317
           LM+ G++ A D WSLG L Y ML G  PF     +  ++ + +I   K +L       ++
Sbjct: 594 LMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNIS 653

Query: 318 QEARDLLKKLLKRNAASRLGA 338
             A+DLL  +L  +   R  A
Sbjct: 654 DGAKDLLSHMLHMDPHQRYTA 674


>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
           [Homo sapiens]
          Length = 549

 Score =  353 bits (907), Expect = 2e-97
 Identities = 190/387 (49%), Positives = 260/387 (67%), Gaps = 14/387 (3%)

Query: 41  EDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKG 100
           E+    GG    S D G  G   L ++H    E+   ++    EK+  E FELL+VLG G
Sbjct: 3   EEGGSSGGAAGTSADGGDGGEQLLTVKH----ELRTANLTGHAEKVGIENFELLKVLGTG 58

Query: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH-PFIVDLI 159
            YGKVF VRK++G +TGK++AMKVLKKA IV+ AK T HT+ ER +LE ++  PF+V L 
Sbjct: 59  AYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLH 118

Query: 160 YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDL 219
           YAFQT  KL+LIL+Y++GGELF  L +   F E     Y+ EI +AL HLH+ GIIYRD+
Sbjct: 119 YAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDI 178

Query: 220 KPENIMLNHQGHVKLTDFGLCKESIHDGTV-THTFCGTIEYMAPEILM--RSGHNRAVDW 276
           K ENI+L+  GHV LTDFGL KE + D T   ++FCGTIEYMAP+I+    SGH++AVDW
Sbjct: 179 KLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDW 238

Query: 277 WSLGALMYDMLTGAPPFTGENRKKT----IDKILKCKLNLPPYLTQEARDLLKKLLKRNA 332
           WSLG LMY++LTGA PFT +  K +      +ILK +   P  ++  A+DL+++LL ++ 
Sbjct: 239 WSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDP 298

Query: 333 ASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPV 392
             RLG GP DA E++ H FF+ INW++L A+KV  PFKP+++ E DVS F  +FT   P 
Sbjct: 299 KKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPT 358

Query: 393 DSPDDSTLSESANQVFLGFTYVAPSVL 419
            SP  + L +S+ ++F G+++VAPS+L
Sbjct: 359 YSP--AALPQSSEKLFQGYSFVAPSIL 383



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 38/122 (31%), Positives = 62/122 (50%), Gaps = 6/122 (4%)

Query: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160
           G G     RK     + + FA+K++ K M     K+    K          HP IV L  
Sbjct: 433 GEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEG------HPNIVKLHE 486

Query: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220
            F      +L++E L+GGELF +++++  F E  A + + ++  A+ H+H  G+++RDLK
Sbjct: 487 VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK 546

Query: 221 PE 222
           PE
Sbjct: 547 PE 548


>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
           [Homo sapiens]
          Length = 802

 Score =  353 bits (907), Expect = 2e-97
 Identities = 190/387 (49%), Positives = 260/387 (67%), Gaps = 14/387 (3%)

Query: 41  EDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKG 100
           E+    GG    S D G  G   L ++H    E+   ++    EK+  E FELL+VLG G
Sbjct: 3   EEGGSSGGAAGTSADGGDGGEQLLTVKH----ELRTANLTGHAEKVGIENFELLKVLGTG 58

Query: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH-PFIVDLI 159
            YGKVF VRK++G +TGK++AMKVLKKA IV+ AK T HT+ ER +LE ++  PF+V L 
Sbjct: 59  AYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLH 118

Query: 160 YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDL 219
           YAFQT  KL+LIL+Y++GGELF  L +   F E     Y+ EI +AL HLH+ GIIYRD+
Sbjct: 119 YAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDI 178

Query: 220 KPENIMLNHQGHVKLTDFGLCKESIHDGTV-THTFCGTIEYMAPEILM--RSGHNRAVDW 276
           K ENI+L+  GHV LTDFGL KE + D T   ++FCGTIEYMAP+I+    SGH++AVDW
Sbjct: 179 KLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDW 238

Query: 277 WSLGALMYDMLTGAPPFTGENRKKT----IDKILKCKLNLPPYLTQEARDLLKKLLKRNA 332
           WSLG LMY++LTGA PFT +  K +      +ILK +   P  ++  A+DL+++LL ++ 
Sbjct: 239 WSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDP 298

Query: 333 ASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPV 392
             RLG GP DA E++ H FF+ INW++L A+KV  PFKP+++ E DVS F  +FT   P 
Sbjct: 299 KKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPT 358

Query: 393 DSPDDSTLSESANQVFLGFTYVAPSVL 419
            SP  + L +S+ ++F G+++VAPS+L
Sbjct: 359 YSP--AALPQSSEKLFQGYSFVAPSIL 383



 Score =  128 bits (321), Expect = 1e-29
 Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 20/250 (8%)

Query: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160
           G G     RK     + + FA+K++ K M     K+    K          HP IV L  
Sbjct: 433 GEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEG------HPNIVKLHE 486

Query: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220
            F      +L++E L+GGELF +++++  F E  A + + ++  A+ H+H  G+++RDLK
Sbjct: 487 VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK 546

Query: 221 PENIML---NHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWW 277
           PEN++    N    +K+ DFG  +    D     T C T+ Y APE+L ++G++ + D W
Sbjct: 547 PENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLW 606

Query: 278 SLGALMYDMLTGAPPFTGENRKKT-------IDKILKCKLNLP----PYLTQEARDLLKK 326
           SLG ++Y ML+G  PF   +R  T       + KI K   +        ++QEA+DL++ 
Sbjct: 607 SLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQG 666

Query: 327 LLKRNAASRL 336
           LL  +   RL
Sbjct: 667 LLTVDPNKRL 676


>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
           isoform b [Homo sapiens]
          Length = 766

 Score =  336 bits (861), Expect = 4e-92
 Identities = 179/356 (50%), Positives = 242/356 (67%), Gaps = 8/356 (2%)

Query: 71  KFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMI 130
           +  I+E ++    EK+  E FELL+VLG G YGKVF VRK  G + GK++AMKVL+KA +
Sbjct: 13  ELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAAL 72

Query: 131 VRNAKDTAHTKAERNILEEVKH-PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI 189
           V+ AK   HT+ ER++LE V+  PF+V L YAFQT  KL+LIL+Y+SGGE+F  L +   
Sbjct: 73  VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132

Query: 190 FMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGT 248
           F E     Y  EI +AL HLH+ GIIYRDLK EN++L+ +GH+ LTDFGL KE +  +  
Sbjct: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192

Query: 249 VTHTFCGTIEYMAPEIL-MRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKT----ID 303
            T +FCGTIEYMAPEI+  ++GH +AVDWWSLG L++++LTGA PFT E  + T      
Sbjct: 193 RTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSR 252

Query: 304 KILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLAR 363
           +ILKC    PP +   A+DLL++LL ++   RLGAGP  A EV+ HPFF+ ++W  L AR
Sbjct: 253 RILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAAR 312

Query: 364 KVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVL 419
           K+  PF+P ++SE DV  F  +FTR  PV SP  S       ++F G+++VAPS+L
Sbjct: 313 KIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSP-PPGDPRIFQGYSFVAPSIL 367



 Score =  110 bits (274), Expect = 4e-24
 Identities = 74/252 (29%), Positives = 128/252 (50%), Gaps = 22/252 (8%)

Query: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160
           G G     R+     +G+ FA+K+L + +     ++ A  +  ++      HP +V+L  
Sbjct: 412 GQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQS------HPNVVNLHE 465

Query: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQK-GIIYRDL 219
                   YL+LE L GGEL   + ++  F E  A   L  +  A+  +H++ G+++RDL
Sbjct: 466 VHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDL 525

Query: 220 KPENIMLNHQ---GHVKLTDFGLCK-ESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVD 275
           KPENI+         VK+ DFG  +      G    T C T++Y APE+L + G++ + D
Sbjct: 526 KPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCD 585

Query: 276 WWSLGALMYDMLTGAPPFTGENRK--KTIDKILKCKLNLPPY---------LTQEARDLL 324
            WSLG ++Y ML+G  PF G + +  ++    + CK+    +         +++EA++L+
Sbjct: 586 LWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELV 645

Query: 325 KKLLKRNAASRL 336
           + LL  + A RL
Sbjct: 646 RGLLTVDPAKRL 657


>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
           isoform a [Homo sapiens]
          Length = 772

 Score =  336 bits (861), Expect = 4e-92
 Identities = 179/356 (50%), Positives = 242/356 (67%), Gaps = 8/356 (2%)

Query: 71  KFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMI 130
           +  I+E ++    EK+  E FELL+VLG G YGKVF VRK  G + GK++AMKVL+KA +
Sbjct: 13  ELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAAL 72

Query: 131 VRNAKDTAHTKAERNILEEVKH-PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI 189
           V+ AK   HT+ ER++LE V+  PF+V L YAFQT  KL+LIL+Y+SGGE+F  L +   
Sbjct: 73  VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132

Query: 190 FMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGT 248
           F E     Y  EI +AL HLH+ GIIYRDLK EN++L+ +GH+ LTDFGL KE +  +  
Sbjct: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192

Query: 249 VTHTFCGTIEYMAPEIL-MRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKT----ID 303
            T +FCGTIEYMAPEI+  ++GH +AVDWWSLG L++++LTGA PFT E  + T      
Sbjct: 193 RTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSR 252

Query: 304 KILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLAR 363
           +ILKC    PP +   A+DLL++LL ++   RLGAGP  A EV+ HPFF+ ++W  L AR
Sbjct: 253 RILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAAR 312

Query: 364 KVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVL 419
           K+  PF+P ++SE DV  F  +FTR  PV SP  S       ++F G+++VAPS+L
Sbjct: 313 KIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSP-PPGDPRIFQGYSFVAPSIL 367



 Score =  110 bits (274), Expect = 4e-24
 Identities = 74/252 (29%), Positives = 128/252 (50%), Gaps = 22/252 (8%)

Query: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160
           G G     R+     +G+ FA+K+L + +     ++ A  +  ++      HP +V+L  
Sbjct: 418 GQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQS------HPNVVNLHE 471

Query: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQK-GIIYRDL 219
                   YL+LE L GGEL   + ++  F E  A   L  +  A+  +H++ G+++RDL
Sbjct: 472 VHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDL 531

Query: 220 KPENIMLNHQ---GHVKLTDFGLCK-ESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVD 275
           KPENI+         VK+ DFG  +      G    T C T++Y APE+L + G++ + D
Sbjct: 532 KPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCD 591

Query: 276 WWSLGALMYDMLTGAPPFTGENRK--KTIDKILKCKLNLPPY---------LTQEARDLL 324
            WSLG ++Y ML+G  PF G + +  ++    + CK+    +         +++EA++L+
Sbjct: 592 LWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELV 651

Query: 325 KKLLKRNAASRL 336
           + LL  + A RL
Sbjct: 652 RGLLTVDPAKRL 663


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  308 bits (789), Expect = 8e-84
 Identities = 163/351 (46%), Positives = 225/351 (64%), Gaps = 18/351 (5%)

Query: 79  VNRGPEK---IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK 135
           +N GP      +P  F  L+V+GKG +GKV   R          +A+KVL+K  I++  K
Sbjct: 83  INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEE---VFYAVKVLQKKAILKK-K 138

Query: 136 DTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDT 194
           +  H  +ERN+L + VKHPF+V L ++FQT  KLY +L+Y++GGELF  L+RE  F+E  
Sbjct: 139 EEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR 198

Query: 195 ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC 254
           A FY AEI+ ALG+LH   I+YRDLKPENI+L+ QGH+ LTDFGLCKE+I   + T TFC
Sbjct: 199 ARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC 258

Query: 255 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP 314
           GT EY+APE+L +  ++R VDWW LGA++Y+ML G PPF   N  +  D IL   L L P
Sbjct: 259 GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 318

Query: 315 YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQ 374
            +T  AR LL+ LL+++   RLGA   D  E+++H FF  INW++L+ +K+ PPF P + 
Sbjct: 319 NITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 377

Query: 375 SEEDVSQFDSKFTRQTPV-----DSPDDSTLSES---ANQVFLGFTYVAPS 417
              D+  FD +FT + PV      SPD   ++ S   A + FLGF+Y  P+
Sbjct: 378 GPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 427


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  308 bits (789), Expect = 8e-84
 Identities = 163/351 (46%), Positives = 225/351 (64%), Gaps = 18/351 (5%)

Query: 79  VNRGPEK---IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK 135
           +N GP      +P  F  L+V+GKG +GKV   R          +A+KVL+K  I++  K
Sbjct: 97  INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEE---VFYAVKVLQKKAILKK-K 152

Query: 136 DTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDT 194
           +  H  +ERN+L + VKHPF+V L ++FQT  KLY +L+Y++GGELF  L+RE  F+E  
Sbjct: 153 EEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR 212

Query: 195 ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC 254
           A FY AEI+ ALG+LH   I+YRDLKPENI+L+ QGH+ LTDFGLCKE+I   + T TFC
Sbjct: 213 ARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC 272

Query: 255 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP 314
           GT EY+APE+L +  ++R VDWW LGA++Y+ML G PPF   N  +  D IL   L L P
Sbjct: 273 GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 332

Query: 315 YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQ 374
            +T  AR LL+ LL+++   RLGA   D  E+++H FF  INW++L+ +K+ PPF P + 
Sbjct: 333 NITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 391

Query: 375 SEEDVSQFDSKFTRQTPV-----DSPDDSTLSES---ANQVFLGFTYVAPS 417
              D+  FD +FT + PV      SPD   ++ S   A + FLGF+Y  P+
Sbjct: 392 GPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 441


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  308 bits (789), Expect = 8e-84
 Identities = 163/351 (46%), Positives = 225/351 (64%), Gaps = 18/351 (5%)

Query: 79  VNRGPEK---IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK 135
           +N GP      +P  F  L+V+GKG +GKV   R          +A+KVL+K  I++  K
Sbjct: 111 INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEE---VFYAVKVLQKKAILKK-K 166

Query: 136 DTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDT 194
           +  H  +ERN+L + VKHPF+V L ++FQT  KLY +L+Y++GGELF  L+RE  F+E  
Sbjct: 167 EEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR 226

Query: 195 ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC 254
           A FY AEI+ ALG+LH   I+YRDLKPENI+L+ QGH+ LTDFGLCKE+I   + T TFC
Sbjct: 227 ARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC 286

Query: 255 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP 314
           GT EY+APE+L +  ++R VDWW LGA++Y+ML G PPF   N  +  D IL   L L P
Sbjct: 287 GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 346

Query: 315 YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQ 374
            +T  AR LL+ LL+++   RLGA   D  E+++H FF  INW++L+ +K+ PPF P + 
Sbjct: 347 NITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 405

Query: 375 SEEDVSQFDSKFTRQTPV-----DSPDDSTLSES---ANQVFLGFTYVAPS 417
              D+  FD +FT + PV      SPD   ++ S   A + FLGF+Y  P+
Sbjct: 406 GPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 455


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  308 bits (789), Expect = 8e-84
 Identities = 163/351 (46%), Positives = 225/351 (64%), Gaps = 18/351 (5%)

Query: 79  VNRGPEK---IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK 135
           +N GP      +P  F  L+V+GKG +GKV   R          +A+KVL+K  I++  K
Sbjct: 178 INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEE---VFYAVKVLQKKAILKK-K 233

Query: 136 DTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDT 194
           +  H  +ERN+L + VKHPF+V L ++FQT  KLY +L+Y++GGELF  L+RE  F+E  
Sbjct: 234 EEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR 293

Query: 195 ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC 254
           A FY AEI+ ALG+LH   I+YRDLKPENI+L+ QGH+ LTDFGLCKE+I   + T TFC
Sbjct: 294 ARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC 353

Query: 255 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP 314
           GT EY+APE+L +  ++R VDWW LGA++Y+ML G PPF   N  +  D IL   L L P
Sbjct: 354 GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 413

Query: 315 YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQ 374
            +T  AR LL+ LL+++   RLGA   D  E+++H FF  INW++L+ +K+ PPF P + 
Sbjct: 414 NITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 472

Query: 375 SEEDVSQFDSKFTRQTPV-----DSPDDSTLSES---ANQVFLGFTYVAPS 417
              D+  FD +FT + PV      SPD   ++ S   A + FLGF+Y  P+
Sbjct: 473 GPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 522


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  306 bits (783), Expect = 4e-83
 Identities = 152/326 (46%), Positives = 214/326 (65%), Gaps = 6/326 (1%)

Query: 73  EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVR 132
           E  E +V++   K+    F+ L++LGKG +GKV  VR+     TG+ +AMK+L+K +I+ 
Sbjct: 134 EEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKA---TGRYYAMKILRKEVII- 189

Query: 133 NAKD-TAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 191
            AKD  AHT  E  +L+  +HPF+  L YAFQT  +L  ++EY +GGELF  L RE +F 
Sbjct: 190 -AKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFT 248

Query: 192 EDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTH 251
           E+ A FY AEI  AL +LH + ++YRD+K EN+ML+  GH+K+TDFGLCKE I DG    
Sbjct: 249 EERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMK 308

Query: 252 TFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLN 311
           TFCGT EY+APE+L  + + RAVDWW LG +MY+M+ G  PF  ++ ++  + IL  ++ 
Sbjct: 309 TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIR 368

Query: 312 LPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 371
            P  L+ EA+ LL  LLK++   RLG GP DA EV  H FF  INW++++ +K+ PPFKP
Sbjct: 369 FPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP 428

Query: 372 LLQSEEDVSQFDSKFTRQTPVDSPDD 397
            + SE D   FD +FT Q+   +P D
Sbjct: 429 QVTSEVDTRYFDDEFTAQSITITPPD 454


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  299 bits (765), Expect = 5e-81
 Identities = 156/344 (45%), Positives = 222/344 (64%), Gaps = 13/344 (3%)

Query: 78  SVNRGPE---KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNA 134
           ++N GP      +P  F+ L+V+GKG YGKV   ++    + G  +A+KVL+K  I++  
Sbjct: 19  NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKK- 74

Query: 135 KDTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMED 193
           K+ +H  AER++L + V+HPF+V L Y+FQT  KLY +L+Y++GGELF  L+RE  F+E 
Sbjct: 75  KEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEP 134

Query: 194 TACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTF 253
            A FY AE++ A+G+LH   IIYRDLKPENI+L+ QGHV LTDFGLCKE +     T TF
Sbjct: 135 RARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTF 194

Query: 254 CGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLP 313
           CGT EY+APE+L +  ++RAVDWW LGA++Y+ML G PPF  ++  +  + IL   L +P
Sbjct: 195 CGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIP 254

Query: 314 PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLL 373
              T  A DLL+ LL ++   RLG+   D  E++ H FF  INW++L  +++ PPF P +
Sbjct: 255 GGRTVAACDLLQSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 313

Query: 374 QSEEDVSQFDSKFTRQTPVDS----PDDSTLSESANQVFLGFTY 413
               D+  FD +FT++    S    PD    S  A+  FLGF+Y
Sbjct: 314 TGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  299 bits (765), Expect = 5e-81
 Identities = 156/344 (45%), Positives = 222/344 (64%), Gaps = 13/344 (3%)

Query: 78  SVNRGPE---KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNA 134
           ++N GP      +P  F+ L+V+GKG YGKV   ++    + G  +A+KVL+K  I++  
Sbjct: 79  NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKK- 134

Query: 135 KDTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMED 193
           K+ +H  AER++L + V+HPF+V L Y+FQT  KLY +L+Y++GGELF  L+RE  F+E 
Sbjct: 135 KEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEP 194

Query: 194 TACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTF 253
            A FY AE++ A+G+LH   IIYRDLKPENI+L+ QGHV LTDFGLCKE +     T TF
Sbjct: 195 RARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTF 254

Query: 254 CGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLP 313
           CGT EY+APE+L +  ++RAVDWW LGA++Y+ML G PPF  ++  +  + IL   L +P
Sbjct: 255 CGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIP 314

Query: 314 PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLL 373
              T  A DLL+ LL ++   RLG+   D  E++ H FF  INW++L  +++ PPF P +
Sbjct: 315 GGRTVAACDLLQSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 373

Query: 374 QSEEDVSQFDSKFTRQTPVDS----PDDSTLSESANQVFLGFTY 413
               D+  FD +FT++    S    PD    S  A+  FLGF+Y
Sbjct: 374 TGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  298 bits (763), Expect = 8e-81
 Identities = 162/359 (45%), Positives = 230/359 (64%), Gaps = 16/359 (4%)

Query: 70  EKFEISETSVNRGPE---KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK 126
           +K   +  ++N GP      +P  F+ L+V+GKG +GKV   ++      GK +A+KVL+
Sbjct: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVLQ 194

Query: 127 KAMIVRNAKDTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLE 185
           K  IV N K+  H  AERN+L + VKHPF+V L Y+FQT  KLY +L++++GGELF  L+
Sbjct: 195 KK-IVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ 253

Query: 186 REGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIH 245
           RE  F E  A FY AEI+ ALG+LH   I+YRDLKPENI+L+  GHV LTDFGLCKE I 
Sbjct: 254 RERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIA 313

Query: 246 DGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKI 305
               T TFCGT EY+APE++ +  ++  VDWW LGA++Y+ML G PPF   +  +  D I
Sbjct: 314 ISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNI 373

Query: 306 LKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKV 365
           L   L+L P ++  A  +L++LL+++  +RLGA   D  E+Q HPFF  ++W +L+ +K+
Sbjct: 374 LHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPFFESLSWADLVQKKI 432

Query: 366 EPPFKPLLQSEEDVSQFDSKFTRQT-PVD---SPDDSTLSES---ANQVFLGFTYVAPS 417
            PPF P +   +D+  FD+ FT +T P     S D S ++ S   A+  F+GF+Y  PS
Sbjct: 433 PPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 491


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  298 bits (763), Expect = 8e-81
 Identities = 162/359 (45%), Positives = 230/359 (64%), Gaps = 16/359 (4%)

Query: 70  EKFEISETSVNRGPE---KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK 126
           +K   +  ++N GP      +P  F+ L+V+GKG +GKV   ++      GK +A+KVL+
Sbjct: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVLQ 194

Query: 127 KAMIVRNAKDTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLE 185
           K  IV N K+  H  AERN+L + VKHPF+V L Y+FQT  KLY +L++++GGELF  L+
Sbjct: 195 KK-IVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ 253

Query: 186 REGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIH 245
           RE  F E  A FY AEI+ ALG+LH   I+YRDLKPENI+L+  GHV LTDFGLCKE I 
Sbjct: 254 RERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIA 313

Query: 246 DGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKI 305
               T TFCGT EY+APE++ +  ++  VDWW LGA++Y+ML G PPF   +  +  D I
Sbjct: 314 ISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNI 373

Query: 306 LKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKV 365
           L   L+L P ++  A  +L++LL+++  +RLGA   D  E+Q HPFF  ++W +L+ +K+
Sbjct: 374 LHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPFFESLSWADLVQKKI 432

Query: 366 EPPFKPLLQSEEDVSQFDSKFTRQT-PVD---SPDDSTLSES---ANQVFLGFTYVAPS 417
            PPF P +   +D+  FD+ FT +T P     S D S ++ S   A+  F+GF+Y  PS
Sbjct: 433 PPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 491


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  297 bits (760), Expect = 2e-80
 Identities = 160/350 (45%), Positives = 217/350 (62%), Gaps = 12/350 (3%)

Query: 73  EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVR 132
           E  E S+ +   ++    FE L++LGKG +GKV  V++     TG+ +AMK+LKK +IV 
Sbjct: 132 EEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIV- 187

Query: 133 NAKD-TAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 191
            AKD  AHT  E  +L+  +HPF+  L Y+FQT  +L  ++EY +GGELF  L RE +F 
Sbjct: 188 -AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS 246

Query: 192 EDTACFYLAEISMALGHLH-QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVT 250
           ED A FY AEI  AL +LH +K ++YRDLK EN+ML+  GH+K+TDFGLCKE I DG   
Sbjct: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306

Query: 251 HTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL 310
            TFCGT EY+APE+L  + + RAVDWW LG +MY+M+ G  PF  ++ +K  + IL  ++
Sbjct: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI 366

Query: 311 NLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFK 370
             P  L  EA+ LL  LLK++   RLG G  DA E+  H FF  I W+ +  +K+ PPFK
Sbjct: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426

Query: 371 PLLQSEEDVSQFDSKFTRQ----TPVDSPDDSTLSESANQV-FLGFTYVA 415
           P + SE D   FD +FT Q    TP D  D     +S  +  F  F+Y A
Sbjct: 427 PQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  297 bits (760), Expect = 2e-80
 Identities = 160/350 (45%), Positives = 217/350 (62%), Gaps = 12/350 (3%)

Query: 73  EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVR 132
           E  E S+ +   ++    FE L++LGKG +GKV  V++     TG+ +AMK+LKK +IV 
Sbjct: 132 EEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIV- 187

Query: 133 NAKD-TAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 191
            AKD  AHT  E  +L+  +HPF+  L Y+FQT  +L  ++EY +GGELF  L RE +F 
Sbjct: 188 -AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS 246

Query: 192 EDTACFYLAEISMALGHLH-QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVT 250
           ED A FY AEI  AL +LH +K ++YRDLK EN+ML+  GH+K+TDFGLCKE I DG   
Sbjct: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306

Query: 251 HTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL 310
            TFCGT EY+APE+L  + + RAVDWW LG +MY+M+ G  PF  ++ +K  + IL  ++
Sbjct: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI 366

Query: 311 NLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFK 370
             P  L  EA+ LL  LLK++   RLG G  DA E+  H FF  I W+ +  +K+ PPFK
Sbjct: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426

Query: 371 PLLQSEEDVSQFDSKFTRQ----TPVDSPDDSTLSESANQV-FLGFTYVA 415
           P + SE D   FD +FT Q    TP D  D     +S  +  F  F+Y A
Sbjct: 427 PQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  297 bits (760), Expect = 2e-80
 Identities = 160/350 (45%), Positives = 217/350 (62%), Gaps = 12/350 (3%)

Query: 73  EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVR 132
           E  E S+ +   ++    FE L++LGKG +GKV  V++     TG+ +AMK+LKK +IV 
Sbjct: 132 EEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIV- 187

Query: 133 NAKD-TAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 191
            AKD  AHT  E  +L+  +HPF+  L Y+FQT  +L  ++EY +GGELF  L RE +F 
Sbjct: 188 -AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS 246

Query: 192 EDTACFYLAEISMALGHLH-QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVT 250
           ED A FY AEI  AL +LH +K ++YRDLK EN+ML+  GH+K+TDFGLCKE I DG   
Sbjct: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306

Query: 251 HTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL 310
            TFCGT EY+APE+L  + + RAVDWW LG +MY+M+ G  PF  ++ +K  + IL  ++
Sbjct: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI 366

Query: 311 NLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFK 370
             P  L  EA+ LL  LLK++   RLG G  DA E+  H FF  I W+ +  +K+ PPFK
Sbjct: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426

Query: 371 PLLQSEEDVSQFDSKFTRQ----TPVDSPDDSTLSESANQV-FLGFTYVA 415
           P + SE D   FD +FT Q    TP D  D     +S  +  F  F+Y A
Sbjct: 427 PQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  294 bits (752), Expect = 2e-79
 Identities = 146/308 (47%), Positives = 201/308 (65%), Gaps = 6/308 (1%)

Query: 91  FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKD-TAHTKAERNILEE 149
           F+ L++LGKG +GKV  VR+     +GK +AMK+LKK +I+  AKD  AHT  E  +L+ 
Sbjct: 148 FDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVII--AKDEVAHTLTESRVLKN 202

Query: 150 VKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHL 209
            +HPF+  L Y+FQT  +L  ++EY++GGELF  L RE +F ED   FY AEI  AL +L
Sbjct: 203 TRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYL 262

Query: 210 HQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSG 269
           H   I+YRDLK EN+ML+  GH+K+TDFGLCKE I D     TFCGT EY+APE+L  + 
Sbjct: 263 HSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDND 322

Query: 270 HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLK 329
           + RAVDWW LG +MY+M+ G  PF  ++ +K  + IL   +  P  L+ +A+ LL  LL 
Sbjct: 323 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLI 382

Query: 330 RNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQ 389
           ++   RLG GP DA E+  H FF  +NW+++  +K+ PPFKP + SE D   FD +FT Q
Sbjct: 383 KDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQ 442

Query: 390 TPVDSPDD 397
           T   +P +
Sbjct: 443 TITITPPE 450


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  294 bits (752), Expect = 2e-79
 Identities = 146/308 (47%), Positives = 201/308 (65%), Gaps = 6/308 (1%)

Query: 91  FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKD-TAHTKAERNILEE 149
           F+ L++LGKG +GKV  VR+     +GK +AMK+LKK +I+  AKD  AHT  E  +L+ 
Sbjct: 148 FDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVII--AKDEVAHTLTESRVLKN 202

Query: 150 VKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHL 209
            +HPF+  L Y+FQT  +L  ++EY++GGELF  L RE +F ED   FY AEI  AL +L
Sbjct: 203 TRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYL 262

Query: 210 HQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSG 269
           H   I+YRDLK EN+ML+  GH+K+TDFGLCKE I D     TFCGT EY+APE+L  + 
Sbjct: 263 HSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDND 322

Query: 270 HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLK 329
           + RAVDWW LG +MY+M+ G  PF  ++ +K  + IL   +  P  L+ +A+ LL  LL 
Sbjct: 323 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLI 382

Query: 330 RNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQ 389
           ++   RLG GP DA E+  H FF  +NW+++  +K+ PPFKP + SE D   FD +FT Q
Sbjct: 383 KDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQ 442

Query: 390 TPVDSPDD 397
           T   +P +
Sbjct: 443 TITITPPE 450


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  279 bits (713), Expect = 5e-75
 Identities = 145/331 (43%), Positives = 207/331 (62%), Gaps = 7/331 (2%)

Query: 91  FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150
           FE +RVLGKG +GKV   R      TG ++A+KVLKK +I+++  D   T  E+ IL   
Sbjct: 355 FEFIRVLGKGSFGKVMLARV---KETGDLYAVKVLKKDVILQD-DDVECTMTEKRILSLA 410

Query: 151 K-HPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHL 209
           + HPF+  L   FQT  +L+ ++E+++GG+L   +++   F E  A FY AEI  AL  L
Sbjct: 411 RNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL 470

Query: 210 HQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSG 269
           H KGIIYRDLK +N++L+H+GH KL DFG+CKE I +G  T TFCGT +Y+APEIL    
Sbjct: 471 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 530

Query: 270 HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLK 329
           +  AVDWW++G L+Y+ML G  PF  EN     + IL  ++  P +L ++A  +LK  + 
Sbjct: 531 YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT 590

Query: 330 RNAASRLGA-GPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTR 388
           +N   RLG+   G    +  HPFF+ I+W +L  R++EPPF+P ++S EDVS FD  F +
Sbjct: 591 KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIK 650

Query: 389 QTPVDSPDDSTLSESANQ-VFLGFTYVAPSV 418
           + PV +P D       NQ  F  F+YV+P +
Sbjct: 651 EEPVLTPIDEGHLPMINQDEFRNFSYVSPEL 681


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  278 bits (710), Expect = 1e-74
 Identities = 153/395 (38%), Positives = 234/395 (59%), Gaps = 25/395 (6%)

Query: 45  EEGGQLNESMDHGGVGPYELGMEHCEKFE-----------ISETSVNRGP----EKIRPE 89
           EEG   N  +  G     E  ME  +KFE           IS +   + P    ++++  
Sbjct: 281 EEGEYYNVPIPEGDE---EGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT 337

Query: 90  CFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEE 149
            F  L VLGKG +GKV    +     T +++A+K+LKK +++++  D   T  E+ +L  
Sbjct: 338 DFNFLMVLGKGSFGKVMLADR---KGTEELYAIKILKKDVVIQD-DDVECTMVEKRVLAL 393

Query: 150 V-KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH 208
           + K PF+  L   FQT  +LY ++EY++GG+L   +++ G F E  A FY AEIS+ L  
Sbjct: 394 LDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFF 453

Query: 209 LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 268
           LH++GIIYRDLK +N+ML+ +GH+K+ DFG+CKE + DG  T TFCGT +Y+APEI+   
Sbjct: 454 LHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQ 513

Query: 269 GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLL 328
            + ++VDWW+ G L+Y+ML G PPF GE+  +    I++  ++ P  L++EA  + K L+
Sbjct: 514 PYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLM 573

Query: 329 KRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTR 388
            ++ A RLG GP    +V+ H FFR I+WE+L  R+++PPFKP +   +    FD  FTR
Sbjct: 574 TKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKV-CGKGAENFDKFFTR 632

Query: 389 QTPVDSPDDSTLSESANQV-FLGFTYVAPSVLESV 422
             PV +P D  +  + +Q  F GF+YV P  +  +
Sbjct: 633 GQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPI 667


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  274 bits (700), Expect = 2e-73
 Identities = 144/390 (36%), Positives = 230/390 (58%), Gaps = 12/390 (3%)

Query: 35  PEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELL 94
           PE + + +EL +  +    +  G   P E       KF+      N   ++++   F  L
Sbjct: 292 PEGSEANEELRQKFE-RAKISQGTKVPEEKTTNTVSKFDN-----NGNRDRMKLTDFNFL 345

Query: 95  RVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE-EVKHP 153
            VLGKG +GKV    +     T +++A+K+LKK +++++  D   T  E+ +L    K P
Sbjct: 346 MVLGKGSFGKVMLSER---KGTDELYAVKILKKDVVIQD-DDVECTMVEKRVLALPGKPP 401

Query: 154 FIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKG 213
           F+  L   FQT  +LY ++EY++GG+L   +++ G F E  A FY AEI++ L  L  KG
Sbjct: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461

Query: 214 IIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRA 273
           IIYRDLK +N+ML+ +GH+K+ DFG+CKE+I DG  T TFCGT +Y+APEI+    + ++
Sbjct: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521

Query: 274 VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAA 333
           VDWW+ G L+Y+ML G  PF GE+  +    I++  +  P  +++EA  + K L+ ++  
Sbjct: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG 581

Query: 334 SRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVD 393
            RLG GP    +++ H FFR+I+WE+L  ++++PP+KP  + + D S FD +FTRQ    
Sbjct: 582 KRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVEL 641

Query: 394 SPDDSTLSESANQ-VFLGFTYVAPSVLESV 422
           +P D     + +Q  F GF+Y  P  + +V
Sbjct: 642 TPTDKLFIMNLDQNEFAGFSYTNPEFVINV 671


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  273 bits (699), Expect = 2e-73
 Identities = 141/331 (42%), Positives = 209/331 (63%), Gaps = 12/331 (3%)

Query: 91  FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHT-KAERNILE- 148
           F    VLG+G +GKV         NT ++FA+K LKK  IV  A+D   +   E+ I E 
Sbjct: 657 FRCCAVLGRGHFGKVLLAEY---KNTNEMFAIKALKKGDIV--ARDEVDSLMCEKRIFET 711

Query: 149 --EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMAL 206
              V+HPF+V+L   FQT   +  ++EY +GG+L M +  + +F E  A FY A + + L
Sbjct: 712 VNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGL 770

Query: 207 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 266
            +LH+  I+YRDLK +N++L+ +G VK+ DFGLCKE +  G  T TFCGT E++APE+L 
Sbjct: 771 QYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 830

Query: 267 RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKK 326
            + + RAVDWW LG L+Y+ML G  PF G++ ++  D I+  ++  P +L+ EA  ++++
Sbjct: 831 ETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR 890

Query: 327 LLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKF 386
           LL+RN   RLGA   DA +V+ HPFFR I+W  L+ +KV+PPF P ++  EDVS FD +F
Sbjct: 891 LLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEF 950

Query: 387 TRQTPVDSP--DDSTLSESANQVFLGFTYVA 415
           T + P+ +P  +   LSE   ++F  F Y+A
Sbjct: 951 TSEAPILTPPREPRILSEEEQEMFRDFDYIA 981


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,955,156
Number of Sequences: 37866
Number of extensions: 1074794
Number of successful extensions: 5103
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 705
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 2765
Number of HSP's gapped (non-prelim): 1027
length of query: 525
length of database: 18,247,518
effective HSP length: 107
effective length of query: 418
effective length of database: 14,195,856
effective search space: 5933867808
effective search space used: 5933867808
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.