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Search of human proteins with 4506325
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506325 protein tyrosine phosphatase, receptor type, R
isoform 1 precursor [Homo sapiens]
(657 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506325 protein tyrosine phosphatase, receptor type, R isofor... 1311 0.0
gi|19743917 protein tyrosine phosphatase, receptor type, R isofo... 831 0.0
gi|90652861 protein-tyrosine-phosphatase non-receptor 5 isoform ... 410 e-114
gi|90652859 protein-tyrosine-phosphatase non-receptor 5 isoform ... 410 e-114
gi|90652853 protein-tyrosine-phosphatase non-receptor 5 isoform ... 410 e-114
gi|18375660 protein tyrosine phosphatase, non-receptor type 7 is... 382 e-106
gi|18375658 protein tyrosine phosphatase, non-receptor type 7 is... 382 e-106
gi|13677222 receptor-type protein tyrosine phosphatase O isoform... 184 2e-46
gi|13677220 receptor-type protein tyrosine phosphatase O isoform... 184 2e-46
gi|13677218 receptor-type protein tyrosine phosphatase O isoform... 184 2e-46
gi|13677216 receptor-type protein tyrosine phosphatase O isoform... 184 2e-46
gi|13677214 receptor-type protein tyrosine phosphatase O isoform... 184 2e-46
gi|4506323 receptor-type protein tyrosine phosphatase O isoform ... 184 2e-46
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 183 4e-46
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 183 4e-46
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 182 9e-46
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 178 2e-44
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 177 4e-44
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 176 8e-44
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 175 1e-43
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 175 1e-43
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 175 1e-43
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 174 3e-43
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 174 3e-43
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 172 7e-43
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 172 7e-43
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 172 7e-43
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 172 7e-43
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 172 9e-43
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 169 7e-42
>gi|4506325 protein tyrosine phosphatase, receptor type, R isoform 1
precursor [Homo sapiens]
Length = 657
Score = 1311 bits (3392), Expect = 0.0
Identities = 657/657 (100%), Positives = 657/657 (100%)
Query: 1 MRRAVCFPALCLLLNLHAAGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQK 60
MRRAVCFPALCLLLNLHAAGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQK
Sbjct: 1 MRRAVCFPALCLLLNLHAAGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQK 60
Query: 61 IYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEVENLPIPAANVIVVT 120
IYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEVENLPIPAANVIVVT
Sbjct: 61 IYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEVENLPIPAANVIVVT 120
Query: 121 LQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDAL 180
LQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDAL
Sbjct: 121 LQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDAL 180
Query: 181 PSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVI 240
PSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVI
Sbjct: 181 PSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVI 240
Query: 241 IVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLN 300
IVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLN
Sbjct: 241 IVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLN 300
Query: 301 VVVDPQGRGAPEIRATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIP 360
VVVDPQGRGAPEIRATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIP
Sbjct: 301 VVVDPQGRGAPEIRATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIP 360
Query: 361 TPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNR 420
TPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNR
Sbjct: 361 TPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNR 420
Query: 421 YKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMV 480
YKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMV
Sbjct: 421 YKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMV 480
Query: 481 WQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSH 540
WQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSH
Sbjct: 481 WQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSH 540
Query: 541 TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIA 600
TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIA
Sbjct: 541 TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIA 600
Query: 601 TSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ 657
TSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ
Sbjct: 601 TSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ 657
>gi|19743917 protein tyrosine phosphatase, receptor type, R isoform
2 [Homo sapiens]
Length = 412
Score = 831 bits (2147), Expect = 0.0
Identities = 412/412 (100%), Positives = 412/412 (100%)
Query: 246 MILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDP 305
MILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDP
Sbjct: 1 MILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDP 60
Query: 306 QGRGAPEIRATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREK 365
QGRGAPEIRATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREK
Sbjct: 61 QGRGAPEIRATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREK 120
Query: 366 VAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTIL 425
VAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTIL
Sbjct: 121 VAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTIL 180
Query: 426 PNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDS 485
PNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDS
Sbjct: 181 PNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDS 240
Query: 486 PVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVK 545
PVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVK
Sbjct: 241 PVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVK 300
Query: 546 HYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGC 605
HYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGC
Sbjct: 301 HYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGC 360
Query: 606 QQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ 657
QQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ
Sbjct: 361 QQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ 412
>gi|90652861 protein-tyrosine-phosphatase non-receptor 5 isoform b
[Homo sapiens]
Length = 533
Score = 410 bits (1054), Expect = e-114
Identities = 226/445 (50%), Positives = 291/445 (65%), Gaps = 28/445 (6%)
Query: 223 WSKEGFYAV----VIFLSIFVIIVTCLMI-LYRLKERFQLSLRQDKEKNQEIHLSPITLQ 277
W G + V ++FLS+ +++VT L+ L R L + ++ Q + P
Sbjct: 103 WLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPE-DRRQSVSRQPSFTY 161
Query: 278 PALSEAKTVHSMVQPEQAPK--VLNVVVDPQGRGAPEIRATTATSVCPSPFKMKPIGLQE 335
E K + + P+ V + V+D + PE T+ T +K +GLQE
Sbjct: 162 SEWMEEKIEDDFLDLDPVPETPVFDCVMDIK----PEADPTSLT--------VKSMGLQE 209
Query: 336 RRGSNVSLTLDMSSLG-NIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSHLLQ 394
RRGSNVSLTLDM + G N E F + +PRE+ A EYL SASR+L +L + LLQ
Sbjct: 210 RRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQ 269
Query: 395 SEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRG 454
+EF EIPMNFVDPKE DIP KNRYKTILPNP SRVCL + D LS+YINANYIRG
Sbjct: 270 AEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRG 329
Query: 455 YSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGK 514
Y G+EK +IATQGP+++TV DFW+MVWQE +P+IVMIT ++E NEKC YWPE++ Y
Sbjct: 330 YGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDG 389
Query: 515 VEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEED 574
VE+ V V ++Y +R + LK G+ + +KHYW+TSWPD KTPD A PLL L+ +VEE
Sbjct: 390 VEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE- 448
Query: 575 RLASQGRG----PVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGM 630
A+Q G P++VHCSAGIGRTGCFIATSI CQQL++EGVVD L CQLR DRGGM
Sbjct: 449 --AAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGM 506
Query: 631 VQTSEQYEFVHHALCLYESRLSAET 655
+QT EQY+FVHH + LYE +LS ++
Sbjct: 507 IQTCEQYQFVHHVMSLYEKQLSHQS 531
>gi|90652859 protein-tyrosine-phosphatase non-receptor 5 isoform a
[Homo sapiens]
Length = 565
Score = 410 bits (1054), Expect = e-114
Identities = 226/445 (50%), Positives = 291/445 (65%), Gaps = 28/445 (6%)
Query: 223 WSKEGFYAV----VIFLSIFVIIVTCLMI-LYRLKERFQLSLRQDKEKNQEIHLSPITLQ 277
W G + V ++FLS+ +++VT L+ L R L + ++ Q + P
Sbjct: 135 WLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPE-DRRQSVSRQPSFTY 193
Query: 278 PALSEAKTVHSMVQPEQAPK--VLNVVVDPQGRGAPEIRATTATSVCPSPFKMKPIGLQE 335
E K + + P+ V + V+D + PE T+ T +K +GLQE
Sbjct: 194 SEWMEEKIEDDFLDLDPVPETPVFDCVMDIK----PEADPTSLT--------VKSMGLQE 241
Query: 336 RRGSNVSLTLDMSSLG-NIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSHLLQ 394
RRGSNVSLTLDM + G N E F + +PRE+ A EYL SASR+L +L + LLQ
Sbjct: 242 RRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQ 301
Query: 395 SEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRG 454
+EF EIPMNFVDPKE DIP KNRYKTILPNP SRVCL + D LS+YINANYIRG
Sbjct: 302 AEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRG 361
Query: 455 YSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGK 514
Y G+EK +IATQGP+++TV DFW+MVWQE +P+IVMIT ++E NEKC YWPE++ Y
Sbjct: 362 YGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDG 421
Query: 515 VEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEED 574
VE+ V V ++Y +R + LK G+ + +KHYW+TSWPD KTPD A PLL L+ +VEE
Sbjct: 422 VEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE- 480
Query: 575 RLASQGRG----PVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGM 630
A+Q G P++VHCSAGIGRTGCFIATSI CQQL++EGVVD L CQLR DRGGM
Sbjct: 481 --AAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGM 538
Query: 631 VQTSEQYEFVHHALCLYESRLSAET 655
+QT EQY+FVHH + LYE +LS ++
Sbjct: 539 IQTCEQYQFVHHVMSLYEKQLSHQS 563
>gi|90652853 protein-tyrosine-phosphatase non-receptor 5 isoform a
[Homo sapiens]
Length = 565
Score = 410 bits (1054), Expect = e-114
Identities = 226/445 (50%), Positives = 291/445 (65%), Gaps = 28/445 (6%)
Query: 223 WSKEGFYAV----VIFLSIFVIIVTCLMI-LYRLKERFQLSLRQDKEKNQEIHLSPITLQ 277
W G + V ++FLS+ +++VT L+ L R L + ++ Q + P
Sbjct: 135 WLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPE-DRRQSVSRQPSFTY 193
Query: 278 PALSEAKTVHSMVQPEQAPK--VLNVVVDPQGRGAPEIRATTATSVCPSPFKMKPIGLQE 335
E K + + P+ V + V+D + PE T+ T +K +GLQE
Sbjct: 194 SEWMEEKIEDDFLDLDPVPETPVFDCVMDIK----PEADPTSLT--------VKSMGLQE 241
Query: 336 RRGSNVSLTLDMSSLG-NIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSHLLQ 394
RRGSNVSLTLDM + G N E F + +PRE+ A EYL SASR+L +L + LLQ
Sbjct: 242 RRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQ 301
Query: 395 SEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRG 454
+EF EIPMNFVDPKE DIP KNRYKTILPNP SRVCL + D LS+YINANYIRG
Sbjct: 302 AEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRG 361
Query: 455 YSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGK 514
Y G+EK +IATQGP+++TV DFW+MVWQE +P+IVMIT ++E NEKC YWPE++ Y
Sbjct: 362 YGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDG 421
Query: 515 VEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEED 574
VE+ V V ++Y +R + LK G+ + +KHYW+TSWPD KTPD A PLL L+ +VEE
Sbjct: 422 VEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE- 480
Query: 575 RLASQGRG----PVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGM 630
A+Q G P++VHCSAGIGRTGCFIATSI CQQL++EGVVD L CQLR DRGGM
Sbjct: 481 --AAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGM 538
Query: 631 VQTSEQYEFVHHALCLYESRLSAET 655
+QT EQY+FVHH + LYE +LS ++
Sbjct: 539 IQTCEQYQFVHHVMSLYEKQLSHQS 563
>gi|18375660 protein tyrosine phosphatase, non-receptor type 7
isoform 2 [Homo sapiens]
Length = 399
Score = 382 bits (982), Expect = e-106
Identities = 192/353 (54%), Positives = 246/353 (69%), Gaps = 7/353 (1%)
Query: 306 QGRGAPEIRATTATSVCPSPFKM---KPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTP 362
+ R P + A P P K K + LQERRGSNV+L LD+ SLG +EP S+ TP
Sbjct: 47 RSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTP 106
Query: 363 REKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYK 422
RE V + +L++A LTR L+ S L+ EF++IP NFV P+++DIP H +K+RYK
Sbjct: 107 RE-VTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYK 165
Query: 423 TILPNPLSRVCL-RPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVW 481
TILPNP SRVCL R ++ D YINANYIRGY GKEK +IATQGPM NTV DFW+MVW
Sbjct: 166 TILPNPQSRVCLGRAQSQEDG--DYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVW 223
Query: 482 QEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHT 541
QE+ +IVM+T+L+E EKCV YWP + YG ++ + + EC YT+R L ++
Sbjct: 224 QEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEER 283
Query: 542 QHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIAT 601
+ VKH +++WPDH+TP+SA PLL+L+ +VEE + GP+VVHCSAGIGRTGCFIAT
Sbjct: 284 RSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIAT 343
Query: 602 SIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAE 654
IGCQQLK G VD L IVCQLR+DRGGM+QT+EQY+F+HH L LY +L E
Sbjct: 344 RIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEE 396
>gi|18375658 protein tyrosine phosphatase, non-receptor type 7
isoform 1 [Homo sapiens]
Length = 360
Score = 382 bits (982), Expect = e-106
Identities = 192/353 (54%), Positives = 246/353 (69%), Gaps = 7/353 (1%)
Query: 306 QGRGAPEIRATTATSVCPSPFKM---KPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTP 362
+ R P + A P P K K + LQERRGSNV+L LD+ SLG +EP S+ TP
Sbjct: 8 RSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTP 67
Query: 363 REKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYK 422
RE V + +L++A LTR L+ S L+ EF++IP NFV P+++DIP H +K+RYK
Sbjct: 68 RE-VTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYK 126
Query: 423 TILPNPLSRVCL-RPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVW 481
TILPNP SRVCL R ++ D YINANYIRGY GKEK +IATQGPM NTV DFW+MVW
Sbjct: 127 TILPNPQSRVCLGRAQSQEDG--DYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVW 184
Query: 482 QEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHT 541
QE+ +IVM+T+L+E EKCV YWP + YG ++ + + EC YT+R L ++
Sbjct: 185 QEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEER 244
Query: 542 QHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIAT 601
+ VKH +++WPDH+TP+SA PLL+L+ +VEE + GP+VVHCSAGIGRTGCFIAT
Sbjct: 245 RSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIAT 304
Query: 602 SIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAE 654
IGCQQLK G VD L IVCQLR+DRGGM+QT+EQY+F+HH L LY +L E
Sbjct: 305 RIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEE 357
>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 184 bits (468), Expect = 2e-46
Identities = 103/241 (42%), Positives = 148/241 (61%), Gaps = 9/241 (3%)
Query: 411 DIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMI 470
D+P + KNRY ILP SRV L N + + YINANYI GY+ ++ +IATQGP+
Sbjct: 147 DLPLNRCKNRYTNILPYDFSRVRLVSMNEEEG-ADYINANYIPGYNSPQE-YIATQGPLP 204
Query: 471 NTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWP--EKRGIYGKVEVLVISVNECDN 527
T +DFW+MV Q+ S +IVM+T+ EK KC YWP E+ YG + V +IS E D+
Sbjct: 205 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 264
Query: 528 YTIRNLVLKQGSHTQHVKHYWYTSWPDHKTP--DSAQPLLQLMLDVEEDRLASQGRGPVV 585
+ R+ + Q V H+ YT+WPDH P ++A+ +LQ + V + A++ +GP++
Sbjct: 265 WACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQ--ATKSKGPMI 322
Query: 586 VHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC 645
+HCSAG+GRTG FIA Q +++ VD L +V ++R R MVQT EQY F+H +
Sbjct: 323 IHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ 382
Query: 646 L 646
L
Sbjct: 383 L 383
>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 184 bits (468), Expect = 2e-46
Identities = 103/241 (42%), Positives = 148/241 (61%), Gaps = 9/241 (3%)
Query: 411 DIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMI 470
D+P + KNRY ILP SRV L N + + YINANYI GY+ ++ +IATQGP+
Sbjct: 119 DLPLNRCKNRYTNILPYDFSRVRLVSMNEEEG-ADYINANYIPGYNSPQE-YIATQGPLP 176
Query: 471 NTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWP--EKRGIYGKVEVLVISVNECDN 527
T +DFW+MV Q+ S +IVM+T+ EK KC YWP E+ YG + V +IS E D+
Sbjct: 177 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
Query: 528 YTIRNLVLKQGSHTQHVKHYWYTSWPDHKTP--DSAQPLLQLMLDVEEDRLASQGRGPVV 585
+ R+ + Q V H+ YT+WPDH P ++A+ +LQ + V + A++ +GP++
Sbjct: 237 WACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQ--ATKSKGPMI 294
Query: 586 VHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC 645
+HCSAG+GRTG FIA Q +++ VD L +V ++R R MVQT EQY F+H +
Sbjct: 295 IHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ 354
Query: 646 L 646
L
Sbjct: 355 L 355
>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 184 bits (468), Expect = 2e-46
Identities = 103/241 (42%), Positives = 148/241 (61%), Gaps = 9/241 (3%)
Query: 411 DIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMI 470
D+P + KNRY ILP SRV L N + + YINANYI GY+ ++ +IATQGP+
Sbjct: 147 DLPLNRCKNRYTNILPYDFSRVRLVSMNEEEG-ADYINANYIPGYNSPQE-YIATQGPLP 204
Query: 471 NTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWP--EKRGIYGKVEVLVISVNECDN 527
T +DFW+MV Q+ S +IVM+T+ EK KC YWP E+ YG + V +IS E D+
Sbjct: 205 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 264
Query: 528 YTIRNLVLKQGSHTQHVKHYWYTSWPDHKTP--DSAQPLLQLMLDVEEDRLASQGRGPVV 585
+ R+ + Q V H+ YT+WPDH P ++A+ +LQ + V + A++ +GP++
Sbjct: 265 WACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQ--ATKSKGPMI 322
Query: 586 VHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC 645
+HCSAG+GRTG FIA Q +++ VD L +V ++R R MVQT EQY F+H +
Sbjct: 323 IHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ 382
Query: 646 L 646
L
Sbjct: 383 L 383
>gi|13677216 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 184 bits (468), Expect = 2e-46
Identities = 103/241 (42%), Positives = 148/241 (61%), Gaps = 9/241 (3%)
Query: 411 DIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMI 470
D+P + KNRY ILP SRV L N + + YINANYI GY+ ++ +IATQGP+
Sbjct: 119 DLPLNRCKNRYTNILPYDFSRVRLVSMNEEEG-ADYINANYIPGYNSPQE-YIATQGPLP 176
Query: 471 NTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWP--EKRGIYGKVEVLVISVNECDN 527
T +DFW+MV Q+ S +IVM+T+ EK KC YWP E+ YG + V +IS E D+
Sbjct: 177 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
Query: 528 YTIRNLVLKQGSHTQHVKHYWYTSWPDHKTP--DSAQPLLQLMLDVEEDRLASQGRGPVV 585
+ R+ + Q V H+ YT+WPDH P ++A+ +LQ + V + A++ +GP++
Sbjct: 237 WACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQ--ATKSKGPMI 294
Query: 586 VHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC 645
+HCSAG+GRTG FIA Q +++ VD L +V ++R R MVQT EQY F+H +
Sbjct: 295 IHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ 354
Query: 646 L 646
L
Sbjct: 355 L 355
>gi|13677214 receptor-type protein tyrosine phosphatase O isoform a
precursor [Homo sapiens]
Length = 1216
Score = 184 bits (468), Expect = 2e-46
Identities = 103/241 (42%), Positives = 148/241 (61%), Gaps = 9/241 (3%)
Query: 411 DIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMI 470
D+P + KNRY ILP SRV L N + + YINANYI GY+ ++ +IATQGP+
Sbjct: 958 DLPLNRCKNRYTNILPYDFSRVRLVSMNEEEG-ADYINANYIPGYNSPQE-YIATQGPLP 1015
Query: 471 NTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWP--EKRGIYGKVEVLVISVNECDN 527
T +DFW+MV Q+ S +IVM+T+ EK KC YWP E+ YG + V +IS E D+
Sbjct: 1016 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 1075
Query: 528 YTIRNLVLKQGSHTQHVKHYWYTSWPDHKTP--DSAQPLLQLMLDVEEDRLASQGRGPVV 585
+ R+ + Q V H+ YT+WPDH P ++A+ +LQ + V + A++ +GP++
Sbjct: 1076 WACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQ--ATKSKGPMI 1133
Query: 586 VHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC 645
+HCSAG+GRTG FIA Q +++ VD L +V ++R R MVQT EQY F+H +
Sbjct: 1134 IHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ 1193
Query: 646 L 646
L
Sbjct: 1194 L 1194
>gi|4506323 receptor-type protein tyrosine phosphatase O isoform b
precursor [Homo sapiens]
Length = 1188
Score = 184 bits (468), Expect = 2e-46
Identities = 103/241 (42%), Positives = 148/241 (61%), Gaps = 9/241 (3%)
Query: 411 DIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMI 470
D+P + KNRY ILP SRV L N + + YINANYI GY+ ++ +IATQGP+
Sbjct: 930 DLPLNRCKNRYTNILPYDFSRVRLVSMNEEEG-ADYINANYIPGYNSPQE-YIATQGPLP 987
Query: 471 NTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWP--EKRGIYGKVEVLVISVNECDN 527
T +DFW+MV Q+ S +IVM+T+ EK KC YWP E+ YG + V +IS E D+
Sbjct: 988 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 1047
Query: 528 YTIRNLVLKQGSHTQHVKHYWYTSWPDHKTP--DSAQPLLQLMLDVEEDRLASQGRGPVV 585
+ R+ + Q V H+ YT+WPDH P ++A+ +LQ + V + A++ +GP++
Sbjct: 1048 WACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQ--ATKSKGPMI 1105
Query: 586 VHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC 645
+HCSAG+GRTG FIA Q +++ VD L +V ++R R MVQT EQY F+H +
Sbjct: 1106 IHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ 1165
Query: 646 L 646
L
Sbjct: 1166 L 1166
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 183 bits (465), Expect = 4e-46
Identities = 108/230 (46%), Positives = 136/230 (59%), Gaps = 7/230 (3%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNRY I+ SRV L + D S YINANYI GY + + +IATQGPM TV DFW
Sbjct: 915 KNRYGNIISYDHSRVRLLVLD-GDPHSDYINANYIDGYH-RPRHYIATQGPMQETVKDFW 972
Query: 478 QMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNL-VL 535
+M+WQE+S IVM+T L E KCV YWP+ +YG ++V +I Y IR V
Sbjct: 973 RMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQ 1032
Query: 536 KQGSHT-QHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGR 594
K+G H + ++ + +TSWPDH P A LL + V+ L GP+VVHCSAG GR
Sbjct: 1033 KKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKF--LNPPEAGPIVVHCSAGAGR 1090
Query: 595 TGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
TGCFIA + EGVVD + V +LR R +VQT EQY FVH A+
Sbjct: 1091 TGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1140
Score = 128 bits (321), Expect = 2e-29
Identities = 91/278 (32%), Positives = 149/278 (53%), Gaps = 18/278 (6%)
Query: 385 DVVASSHLLQSEF--MEIPMNFVDPKEIDI---PRHGTKNRYKTILPNPLSRVCLRPKNV 439
D +S ++ EF + I V P++ I PR+ KNR +LP L R +V
Sbjct: 1167 DPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLP--LDRCLPFLISV 1224
Query: 440 TDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE 499
S YINA + + + AF+ TQ P+ NTV DFW++V+ + +VM+ ++ + +
Sbjct: 1225 DGESSNYINAALMDSHK-QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM-DTAQ 1282
Query: 500 KCVLYWPEKR-GIYGKVEVLVISVNECDN-----YTIRNLVLKQGSHTQHVKHYWYTSWP 553
C+ YWPEK G YG ++V +S + ++ + I N+ Q + + V+H Y WP
Sbjct: 1283 FCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGY-RIVQHLQYIGWP 1341
Query: 554 DHK-TPDSAQPLLQLMLDVEEDRLASQGR-GPVVVHCSAGIGRTGCFIATSIGCQQLKEE 611
++ TP S + LL+++ +E+ + GR G VVHC G GR+G F A C+ ++++
Sbjct: 1342 AYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQ 1401
Query: 612 GVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYES 649
++D IV LR ++ MV+T EQY+FV+ Y S
Sbjct: 1402 NIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS 1439
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 183 bits (465), Expect = 4e-46
Identities = 108/230 (46%), Positives = 136/230 (59%), Gaps = 7/230 (3%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNRY I+ SRV L + D S YINANYI GY + + +IATQGPM TV DFW
Sbjct: 934 KNRYGNIISYDHSRVRLLVLD-GDPHSDYINANYIDGYH-RPRHYIATQGPMQETVKDFW 991
Query: 478 QMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNL-VL 535
+M+WQE+S IVM+T L E KCV YWP+ +YG ++V +I Y IR V
Sbjct: 992 RMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQ 1051
Query: 536 KQGSHT-QHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGR 594
K+G H + ++ + +TSWPDH P A LL + V+ L GP+VVHCSAG GR
Sbjct: 1052 KKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKF--LNPPEAGPIVVHCSAGAGR 1109
Query: 595 TGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
TGCFIA + EGVVD + V +LR R +VQT EQY FVH A+
Sbjct: 1110 TGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159
Score = 128 bits (321), Expect = 2e-29
Identities = 91/278 (32%), Positives = 149/278 (53%), Gaps = 18/278 (6%)
Query: 385 DVVASSHLLQSEF--MEIPMNFVDPKEIDI---PRHGTKNRYKTILPNPLSRVCLRPKNV 439
D +S ++ EF + I V P++ I PR+ KNR +LP L R +V
Sbjct: 1186 DPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLP--LDRCLPFLISV 1243
Query: 440 TDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE 499
S YINA + + + AF+ TQ P+ NTV DFW++V+ + +VM+ ++ + +
Sbjct: 1244 DGESSNYINAALMDSHK-QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM-DTAQ 1301
Query: 500 KCVLYWPEKR-GIYGKVEVLVISVNECDN-----YTIRNLVLKQGSHTQHVKHYWYTSWP 553
C+ YWPEK G YG ++V +S + ++ + I N+ Q + + V+H Y WP
Sbjct: 1302 FCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGY-RIVQHLQYIGWP 1360
Query: 554 DHK-TPDSAQPLLQLMLDVEEDRLASQGR-GPVVVHCSAGIGRTGCFIATSIGCQQLKEE 611
++ TP S + LL+++ +E+ + GR G VVHC G GR+G F A C+ ++++
Sbjct: 1361 AYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQ 1420
Query: 612 GVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYES 649
++D IV LR ++ MV+T EQY+FV+ Y S
Sbjct: 1421 NIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS 1458
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 182 bits (462), Expect = 9e-46
Identities = 106/241 (43%), Positives = 135/241 (56%), Gaps = 9/241 (3%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNRY I+ SRV L+P D S YINANYI GY + +IATQGP+ TV DFW
Sbjct: 914 KNRYGNIIAYDHSRVILQPVE-DDPSSDYINANYIDGYQ-RPSHYIATQGPVHETVYDFW 971
Query: 478 QMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLK 536
+M+WQE S IVM+T L E KC YWP+ +YG +V + + Y +R L+
Sbjct: 972 RMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLE 1031
Query: 537 QGSHTQ--HVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGR 594
+ + + VK + +T WPDH P A LL + V+ S G P+VVHCSAG GR
Sbjct: 1032 RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAG--PIVVHCSAGAGR 1089
Query: 595 TGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAE 654
TGC+I I + EGVVD + V LR R MVQT EQY F+H A + E+ L E
Sbjct: 1090 TGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDA--ILEACLCGE 1147
Query: 655 T 655
T
Sbjct: 1148 T 1148
Score = 117 bits (294), Expect = 3e-26
Identities = 81/244 (33%), Positives = 124/244 (50%), Gaps = 13/244 (5%)
Query: 412 IPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMIN 471
+PR+ KNR+ +LP L + S YINA + Y + AFI TQ P+ N
Sbjct: 1198 LPRNHDKNRFMDMLPPDRCLPFLI--TIDGESSNYINAALMDSYR-QPAAFIVTQYPLPN 1254
Query: 472 TVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGI-YGKVEVLVISVN-ECDN-- 527
TV DFW++V+ IVM+ ++ + ++ C YWPE+ + YG ++V +S + +CD
Sbjct: 1255 TVKDFWRLVYDYGCTSIVMLNEV-DLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVIN 1313
Query: 528 --YTIRNLVLKQGSHTQHVKHYWYTSWPDHK-TPDSAQPLLQLMLDVEE-DRLASQGRGP 583
+ I NL Q + V+ + Y W H+ P S + L+L+L VE+ +G G
Sbjct: 1314 RIFRICNLTRPQEGYLM-VQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGR 1372
Query: 584 VVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHA 643
++HC G GR+G F A I + +K + VVD V LR + MV+ EQY F +
Sbjct: 1373 TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDV 1432
Query: 644 LCLY 647
Y
Sbjct: 1433 ALEY 1436
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 178 bits (451), Expect = 2e-44
Identities = 100/231 (43%), Positives = 136/231 (58%), Gaps = 7/231 (3%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNRY +LP +SRV L + T S YINANY+ GY K K FIATQGP+ NT+ DFW
Sbjct: 1068 KNRYNNVLPYDISRVKLSVQ--THSTDDYINANYMPGYHSK-KDFIATQGPLPNTLKDFW 1124
Query: 478 QMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRGI-YGKVEVLVISVNECDNYTIRNLVL 535
+MVW+++ I+M+TK E+ KC YWP K+ YG + V + S +TIR+ +
Sbjct: 1125 RMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTV 1184
Query: 536 K--QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIG 593
K Q S + ++ + +TSWPDH PD+ L+ V + S P++VHCSAG+G
Sbjct: 1185 KNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVG 1244
Query: 594 RTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
RTG FIA Q++ E VD IV LRM R MVQT +QY F++ +
Sbjct: 1245 RTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV 1295
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 177 bits (448), Expect = 4e-44
Identities = 119/322 (36%), Positives = 173/322 (53%), Gaps = 34/322 (10%)
Query: 355 PFVSIPTPREKVAM-EYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVD----PKE 409
P + IP E + + ++++ + + +Q H +F E+ D +
Sbjct: 817 PIIPIPDDMEAIPVKQFVKHIGELYSNNQ--------HGFSEDFEEVQRCTADMNITAEH 868
Query: 410 IDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSL-STYINANYIRGYSGKEKAFIATQGP 468
+ P + KNRY IL SRV LRP DS S YINANY+ GY+ K KA+IATQGP
Sbjct: 869 SNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYN-KAKAYIATQGP 927
Query: 469 MINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWP-EKRGIYGKVEVLVIS--VNE 524
+ +T +DFW+M+W++++ +IVMIT L EK KC YWP E YG + V + S ++
Sbjct: 928 LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHA 987
Query: 525 C---DNYTIRNLVLKQGS--------HTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEE 573
C ++IRN +K+G + + V Y YT WPD P+ A P+L +
Sbjct: 988 CYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSA 1047
Query: 574 DRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQT 633
R+ G PV+VHCSAG+GRTG +I QQ+K++ V+ L + +R R +VQT
Sbjct: 1048 ARMPETG--PVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQT 1105
Query: 634 SEQYEFVHHALCLYESRLSAET 655
EQY F+H A L E+ L ET
Sbjct: 1106 EEQYIFIHDA--LLEAILGKET 1125
Score = 105 bits (262), Expect = 1e-22
Identities = 68/237 (28%), Positives = 112/237 (47%), Gaps = 17/237 (7%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNR +++P+ +RV L P + YINA+YI GY + FI TQ P+ +T DFW
Sbjct: 1178 KNRNSSVVPSERARVGLAPLPGMKG-TDYINASYIMGYY-RSNEFIITQHPLPHTTKDFW 1235
Query: 478 QMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRN----- 532
+M+W ++ +IVM+ + E +YWP + E +++ D + N
Sbjct: 1236 RMIWDHNAQIIVMLPDNQSLAEDEFVYWPSREESM-NCEAFTVTLISKDRLCLSNEEQII 1294
Query: 533 -----LVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVH 587
L Q + V+H+ WP+ P S+ +L+ ++E+ L GP +VH
Sbjct: 1295 IHDFILEATQDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEEALTRD--GPTIVH 1350
Query: 588 CSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
G G A + QQL+ E VD + + + R G+ EQY+F++ A+
Sbjct: 1351 DEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM 1407
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 176 bits (445), Expect = 8e-44
Identities = 106/247 (42%), Positives = 135/247 (54%), Gaps = 15/247 (6%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIR------GYSGKEKAFIATQGPMIN 471
KNRY I+ SRV L+P D S YINANYI GY + +IATQGP+
Sbjct: 914 KNRYGNIIAYDHSRVILQPVE-DDPSSDYINANYIDIWLYRDGYQ-RPSHYIATQGPVHE 971
Query: 472 TVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRGIYGKVEVLVISVNECDNYTI 530
TV DFW+M+WQE S IVM+T L E KC YWP+ +YG +V + + Y +
Sbjct: 972 TVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVV 1031
Query: 531 RNLVLKQGSHTQ--HVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHC 588
R L++ + + VK + +T WPDH P A LL + V+ S G P+VVHC
Sbjct: 1032 RTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAG--PIVVHC 1089
Query: 589 SAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYE 648
SAG GRTGC+I I + EGVVD + V LR R MVQT EQY F+H A + E
Sbjct: 1090 SAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDA--ILE 1147
Query: 649 SRLSAET 655
+ L ET
Sbjct: 1148 ACLCGET 1154
Score = 117 bits (294), Expect = 3e-26
Identities = 81/244 (33%), Positives = 124/244 (50%), Gaps = 13/244 (5%)
Query: 412 IPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMIN 471
+PR+ KNR+ +LP L + S YINA + Y + AFI TQ P+ N
Sbjct: 1204 LPRNHDKNRFMDMLPPDRCLPFLI--TIDGESSNYINAALMDSYR-QPAAFIVTQYPLPN 1260
Query: 472 TVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGI-YGKVEVLVISVN-ECDN-- 527
TV DFW++V+ IVM+ ++ + ++ C YWPE+ + YG ++V +S + +CD
Sbjct: 1261 TVKDFWRLVYDYGCTSIVMLNEV-DLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVIN 1319
Query: 528 --YTIRNLVLKQGSHTQHVKHYWYTSWPDHK-TPDSAQPLLQLMLDVEE-DRLASQGRGP 583
+ I NL Q + V+ + Y W H+ P S + L+L+L VE+ +G G
Sbjct: 1320 RIFRICNLTRPQEGYLM-VQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGR 1378
Query: 584 VVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHA 643
++HC G GR+G F A I + +K + VVD V LR + MV+ EQY F +
Sbjct: 1379 TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDV 1438
Query: 644 LCLY 647
Y
Sbjct: 1439 ALEY 1442
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform
3 precursor [Homo sapiens]
Length = 1256
Score = 175 bits (443), Expect = 1e-43
Identities = 114/293 (38%), Positives = 153/293 (52%), Gaps = 13/293 (4%)
Query: 364 EKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNF--VDPKEIDIPRHGTKNRY 421
EK M + IL + R + L +EF IP F KE P + KNRY
Sbjct: 574 EKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRY 633
Query: 422 KTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVW 481
ILP +RV L N D+ S YINA+YI G+ K +IA QGP TVDDFW+M+W
Sbjct: 634 VDILPYDYNRVELSEIN-GDAGSNYINASYIDGFKEPRK-YIAAQGPRDETVDDFWRMIW 691
Query: 482 QEDSPVIVMITKLKEKNE-KCVLYWP---EKRGIYGKVEVLVISVNECDNYTIRNLVL-- 535
++ + VIVM+T+ +E N KC YWP E +G V V + C +Y I+ L +
Sbjct: 692 EQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVN 751
Query: 536 -KQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGR 594
K+ + + V H +TSWPDH P+ LL+L V + ++ GP+VVHCSAG+GR
Sbjct: 752 KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRV--NAFSNFFSGPIVVHCSAGVGR 809
Query: 595 TGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY 647
TG +I + L+ E VD V +LR R MVQ QY +H AL Y
Sbjct: 810 TGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 862
Score = 125 bits (314), Expect = 1e-28
Identities = 87/296 (29%), Positives = 146/296 (49%), Gaps = 40/296 (13%)
Query: 384 RDVVASSHLLQSEFMEIPM------NFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPK 437
RD + L++EF +P + +E + +KNR ++P +RV L+ +
Sbjct: 885 RDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQE----ENKSKNRNSNVIPYDYNRVPLKHE 940
Query: 438 ------------------NVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQM 479
+ ++ S YINA++I Y K + IA QGP+ T+ DFWQM
Sbjct: 941 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSY-WKPEVMIAAQGPLKETIGDFWQM 999
Query: 480 VWQEDSPVIVMITKLKEKNEK-CVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQG 538
++Q VIVM+T+LK +++ C YW E + YG +EV + ++ YT+R L+
Sbjct: 1000 IFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
Query: 539 SH--TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEE---DRLASQGRG-----PVVVHC 588
++ V Y YT+W + P + L+ ++ V++ + +S+G P+++HC
Sbjct: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119
Query: 589 SAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
G +TG F A + + E VVD +V LR R GMV T EQY+F++ +
Sbjct: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1175
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform
1 precursor [Homo sapiens]
Length = 1304
Score = 175 bits (443), Expect = 1e-43
Identities = 114/293 (38%), Positives = 153/293 (52%), Gaps = 13/293 (4%)
Query: 364 EKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNF--VDPKEIDIPRHGTKNRY 421
EK M + IL + R + L +EF IP F KE P + KNRY
Sbjct: 622 EKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRY 681
Query: 422 KTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVW 481
ILP +RV L N D+ S YINA+YI G+ K +IA QGP TVDDFW+M+W
Sbjct: 682 VDILPYDYNRVELSEIN-GDAGSNYINASYIDGFKEPRK-YIAAQGPRDETVDDFWRMIW 739
Query: 482 QEDSPVIVMITKLKEKNE-KCVLYWP---EKRGIYGKVEVLVISVNECDNYTIRNLVL-- 535
++ + VIVM+T+ +E N KC YWP E +G V V + C +Y I+ L +
Sbjct: 740 EQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVN 799
Query: 536 -KQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGR 594
K+ + + V H +TSWPDH P+ LL+L V + ++ GP+VVHCSAG+GR
Sbjct: 800 KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRV--NAFSNFFSGPIVVHCSAGVGR 857
Query: 595 TGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY 647
TG +I + L+ E VD V +LR R MVQ QY +H AL Y
Sbjct: 858 TGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 910
Score = 125 bits (314), Expect = 1e-28
Identities = 87/296 (29%), Positives = 146/296 (49%), Gaps = 40/296 (13%)
Query: 384 RDVVASSHLLQSEFMEIPM------NFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPK 437
RD + L++EF +P + +E + +KNR ++P +RV L+ +
Sbjct: 933 RDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQE----ENKSKNRNSNVIPYDYNRVPLKHE 988
Query: 438 ------------------NVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQM 479
+ ++ S YINA++I Y K + IA QGP+ T+ DFWQM
Sbjct: 989 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSY-WKPEVMIAAQGPLKETIGDFWQM 1047
Query: 480 VWQEDSPVIVMITKLKEKNEK-CVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQG 538
++Q VIVM+T+LK +++ C YW E + YG +EV + ++ YT+R L+
Sbjct: 1048 IFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1107
Query: 539 SH--TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEE---DRLASQGRG-----PVVVHC 588
++ V Y YT+W + P + L+ ++ V++ + +S+G P+++HC
Sbjct: 1108 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1167
Query: 589 SAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
G +TG F A + + E VVD +V LR R GMV T EQY+F++ +
Sbjct: 1168 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1223
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform
2 precursor [Homo sapiens]
Length = 1143
Score = 175 bits (443), Expect = 1e-43
Identities = 114/293 (38%), Positives = 153/293 (52%), Gaps = 13/293 (4%)
Query: 364 EKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNF--VDPKEIDIPRHGTKNRY 421
EK M + IL + R + L +EF IP F KE P + KNRY
Sbjct: 461 EKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRY 520
Query: 422 KTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVW 481
ILP +RV L N D+ S YINA+YI G+ K +IA QGP TVDDFW+M+W
Sbjct: 521 VDILPYDYNRVELSEIN-GDAGSNYINASYIDGFKEPRK-YIAAQGPRDETVDDFWRMIW 578
Query: 482 QEDSPVIVMITKLKEKNE-KCVLYWP---EKRGIYGKVEVLVISVNECDNYTIRNLVL-- 535
++ + VIVM+T+ +E N KC YWP E +G V V + C +Y I+ L +
Sbjct: 579 EQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVN 638
Query: 536 -KQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGR 594
K+ + + V H +TSWPDH P+ LL+L V + ++ GP+VVHCSAG+GR
Sbjct: 639 KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRV--NAFSNFFSGPIVVHCSAGVGR 696
Query: 595 TGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY 647
TG +I + L+ E VD V +LR R MVQ QY +H AL Y
Sbjct: 697 TGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 749
Score = 125 bits (314), Expect = 1e-28
Identities = 87/296 (29%), Positives = 146/296 (49%), Gaps = 40/296 (13%)
Query: 384 RDVVASSHLLQSEFMEIPM------NFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPK 437
RD + L++EF +P + +E + +KNR ++P +RV L+ +
Sbjct: 772 RDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQE----ENKSKNRNSNVIPYDYNRVPLKHE 827
Query: 438 ------------------NVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQM 479
+ ++ S YINA++I Y K + IA QGP+ T+ DFWQM
Sbjct: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSY-WKPEVMIAAQGPLKETIGDFWQM 886
Query: 480 VWQEDSPVIVMITKLKEKNEK-CVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQG 538
++Q VIVM+T+LK +++ C YW E + YG +EV + ++ YT+R L+
Sbjct: 887 IFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
Query: 539 SH--TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEE---DRLASQGRG-----PVVVHC 588
++ V Y YT+W + P + L+ ++ V++ + +S+G P+++HC
Sbjct: 947 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006
Query: 589 SAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
G +TG F A + + E VVD +V LR R GMV T EQY+F++ +
Sbjct: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1062
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 174 bits (440), Expect = 3e-43
Identities = 101/230 (43%), Positives = 131/230 (56%), Gaps = 7/230 (3%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNRY I+ SRV L+ D+ S YIN NYI GY + +IATQGPM T+ DFW
Sbjct: 926 KNRYGNIIAYDHSRVRLQTIE-GDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFW 983
Query: 478 QMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVL- 535
+MVW E++ I+M+T L E KC YWP+ IY ++V +I Y IR +
Sbjct: 984 RMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVE 1043
Query: 536 KQGSHT-QHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGR 594
K+G H + ++ + +T WPDH P A LL + V+ S G P+VVHCSAG GR
Sbjct: 1044 KRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAG--PLVVHCSAGAGR 1101
Query: 595 TGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
TGCFI I + EGVVD + V +LR R MVQT EQY F+H A+
Sbjct: 1102 TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1151
Score = 105 bits (263), Expect = 1e-22
Identities = 77/244 (31%), Positives = 120/244 (49%), Gaps = 13/244 (5%)
Query: 412 IPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMIN 471
+PR+ KNR ILP L + S YINA + Y + AFI TQ P+ N
Sbjct: 1210 LPRNHEKNRCMDILPPDRCLPFLI--TIDGESSNYINAALMDSYK-QPSAFIVTQHPLPN 1266
Query: 472 TVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIY--GKVEVLVISVNECDNYT 529
TV DFW++V +VM+ + + + C YWPE G++ G ++V +S + ++
Sbjct: 1267 TVKDFWRLVLDYHCTSVVMLNDV-DPAQLCPQYWPEN-GVHRHGPIQVEFVSADLEEDII 1324
Query: 530 IRNLVLKQGSHTQH----VKHYWYTSWPDHK-TPDSAQPLLQLMLDVEE-DRLASQGRGP 583
R + + Q V+ + + WP ++ TP S + L+L+ V++ + G G
Sbjct: 1325 SRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR 1384
Query: 584 VVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHA 643
VVHC G GR+G F A SI C+ L+ + VD V LR ++ MV +QY+F +
Sbjct: 1385 TVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1444
Query: 644 LCLY 647
Y
Sbjct: 1445 ALEY 1448
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 174 bits (440), Expect = 3e-43
Identities = 101/230 (43%), Positives = 131/230 (56%), Gaps = 7/230 (3%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNRY I+ SRV L+ D+ S YIN NYI GY + +IATQGPM T+ DFW
Sbjct: 939 KNRYGNIIAYDHSRVRLQTIE-GDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFW 996
Query: 478 QMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVL- 535
+MVW E++ I+M+T L E KC YWP+ IY ++V +I Y IR +
Sbjct: 997 RMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVE 1056
Query: 536 KQGSHT-QHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGR 594
K+G H + ++ + +T WPDH P A LL + V+ S G P+VVHCSAG GR
Sbjct: 1057 KRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAG--PLVVHCSAGAGR 1114
Query: 595 TGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
TGCFI I + EGVVD + V +LR R MVQT EQY F+H A+
Sbjct: 1115 TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1164
Score = 105 bits (263), Expect = 1e-22
Identities = 77/244 (31%), Positives = 120/244 (49%), Gaps = 13/244 (5%)
Query: 412 IPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMIN 471
+PR+ KNR ILP L + S YINA + Y + AFI TQ P+ N
Sbjct: 1223 LPRNHEKNRCMDILPPDRCLPFLI--TIDGESSNYINAALMDSYK-QPSAFIVTQHPLPN 1279
Query: 472 TVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIY--GKVEVLVISVNECDNYT 529
TV DFW++V +VM+ + + + C YWPE G++ G ++V +S + ++
Sbjct: 1280 TVKDFWRLVLDYHCTSVVMLNDV-DPAQLCPQYWPEN-GVHRHGPIQVEFVSADLEEDII 1337
Query: 530 IRNLVLKQGSHTQH----VKHYWYTSWPDHK-TPDSAQPLLQLMLDVEE-DRLASQGRGP 583
R + + Q V+ + + WP ++ TP S + L+L+ V++ + G G
Sbjct: 1338 SRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR 1397
Query: 584 VVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHA 643
VVHC G GR+G F A SI C+ L+ + VD V LR ++ MV +QY+F +
Sbjct: 1398 TVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1457
Query: 644 LCLY 647
Y
Sbjct: 1458 ALEY 1461
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 172 bits (437), Expect = 7e-43
Identities = 95/231 (41%), Positives = 133/231 (57%), Gaps = 8/231 (3%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNRY ++ SRV L+P S YINANY+ GY + A+IATQGP+ T DFW
Sbjct: 976 KNRYANVIAYDHSRVILQPIEGIMG-SDYINANYVDGYRC-QNAYIATQGPLPETFGDFW 1033
Query: 478 QMVWQEDSPVIVMITKLKEKNE-KCVLYWPEK-RGIYGKVEVLVISVNECDNYTIRNLVL 535
+MVW++ S IVM+T+L+EK+ KC YWP + YG ++V ++ E + +R L
Sbjct: 1034 RMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSL 1093
Query: 536 KQG--SHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIG 593
+ S + V+ + +T+WPDH P+ P L + V+ GP+VVHCSAG+G
Sbjct: 1094 HKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN--PPDAGPIVVHCSAGVG 1151
Query: 594 RTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
RTGCFI +++K E VD V +R R MVQT +QY F+H AL
Sbjct: 1152 RTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1202
Score = 168 bits (426), Expect = 1e-41
Identities = 92/241 (38%), Positives = 138/241 (57%), Gaps = 6/241 (2%)
Query: 411 DIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMI 470
++P + KNR I+P +RVCL+P + S YINA++I GY ++KA+IATQGP+
Sbjct: 1258 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFIDGYR-QQKAYIATQGPLA 1315
Query: 471 NTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRGI-YGKVEVLVISVNECDNY 528
T +DFW+M+W+ +S ++VM+TKL+E EKC YWP +R Y V ++ Y
Sbjct: 1316 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1375
Query: 529 TIRNLVLKQGSHTQH--VKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVV 586
+R + Q V+ + +T WP+ P S + + + V + + GP+ V
Sbjct: 1376 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1435
Query: 587 HCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCL 646
HCSAG+GRTG FI SI ++++ EGVVD V LR R MVQT ++Y+F + A
Sbjct: 1436 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1495
Query: 647 Y 647
Y
Sbjct: 1496 Y 1496
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 172 bits (437), Expect = 7e-43
Identities = 95/231 (41%), Positives = 133/231 (57%), Gaps = 8/231 (3%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNRY ++ SRV L+P S YINANY+ GY + A+IATQGP+ T DFW
Sbjct: 1381 KNRYANVIAYDHSRVILQPIEGIMG-SDYINANYVDGYRC-QNAYIATQGPLPETFGDFW 1438
Query: 478 QMVWQEDSPVIVMITKLKEKNE-KCVLYWPEK-RGIYGKVEVLVISVNECDNYTIRNLVL 535
+MVW++ S IVM+T+L+EK+ KC YWP + YG ++V ++ E + +R L
Sbjct: 1439 RMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSL 1498
Query: 536 KQG--SHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIG 593
+ S + V+ + +T+WPDH P+ P L + V+ GP+VVHCSAG+G
Sbjct: 1499 HKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN--PPDAGPIVVHCSAGVG 1556
Query: 594 RTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
RTGCFI +++K E VD V +R R MVQT +QY F+H AL
Sbjct: 1557 RTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1607
Score = 168 bits (426), Expect = 1e-41
Identities = 92/241 (38%), Positives = 138/241 (57%), Gaps = 6/241 (2%)
Query: 411 DIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMI 470
++P + KNR I+P +RVCL+P + S YINA++I GY ++KA+IATQGP+
Sbjct: 1663 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFIDGYR-QQKAYIATQGPLA 1720
Query: 471 NTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRGI-YGKVEVLVISVNECDNY 528
T +DFW+M+W+ +S ++VM+TKL+E EKC YWP +R Y V ++ Y
Sbjct: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1780
Query: 529 TIRNLVLKQGSHTQH--VKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVV 586
+R + Q V+ + +T WP+ P S + + + V + + GP+ V
Sbjct: 1781 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1840
Query: 587 HCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCL 646
HCSAG+GRTG FI SI ++++ EGVVD V LR R MVQT ++Y+F + A
Sbjct: 1841 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1900
Query: 647 Y 647
Y
Sbjct: 1901 Y 1901
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 172 bits (437), Expect = 7e-43
Identities = 95/231 (41%), Positives = 133/231 (57%), Gaps = 8/231 (3%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNRY ++ SRV L+P S YINANY+ GY + A+IATQGP+ T DFW
Sbjct: 972 KNRYANVIAYDHSRVILQPIEGIMG-SDYINANYVDGYRC-QNAYIATQGPLPETFGDFW 1029
Query: 478 QMVWQEDSPVIVMITKLKEKNE-KCVLYWPEK-RGIYGKVEVLVISVNECDNYTIRNLVL 535
+MVW++ S IVM+T+L+EK+ KC YWP + YG ++V ++ E + +R L
Sbjct: 1030 RMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSL 1089
Query: 536 KQG--SHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIG 593
+ S + V+ + +T+WPDH P+ P L + V+ GP+VVHCSAG+G
Sbjct: 1090 HKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN--PPDAGPIVVHCSAGVG 1147
Query: 594 RTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
RTGCFI +++K E VD V +R R MVQT +QY F+H AL
Sbjct: 1148 RTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1198
Score = 168 bits (426), Expect = 1e-41
Identities = 92/241 (38%), Positives = 138/241 (57%), Gaps = 6/241 (2%)
Query: 411 DIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMI 470
++P + KNR I+P +RVCL+P + S YINA++I GY ++KA+IATQGP+
Sbjct: 1254 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFIDGYR-QQKAYIATQGPLA 1311
Query: 471 NTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRGI-YGKVEVLVISVNECDNY 528
T +DFW+M+W+ +S ++VM+TKL+E EKC YWP +R Y V ++ Y
Sbjct: 1312 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1371
Query: 529 TIRNLVLKQGSHTQH--VKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVV 586
+R + Q V+ + +T WP+ P S + + + V + + GP+ V
Sbjct: 1372 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1431
Query: 587 HCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCL 646
HCSAG+GRTG FI SI ++++ EGVVD V LR R MVQT ++Y+F + A
Sbjct: 1432 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1491
Query: 647 Y 647
Y
Sbjct: 1492 Y 1492
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 172 bits (437), Expect = 7e-43
Identities = 95/231 (41%), Positives = 133/231 (57%), Gaps = 8/231 (3%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNRY ++ SRV L+P S YINANY+ GY + A+IATQGP+ T DFW
Sbjct: 1419 KNRYANVIAYDHSRVILQPIEGIMG-SDYINANYVDGYRC-QNAYIATQGPLPETFGDFW 1476
Query: 478 QMVWQEDSPVIVMITKLKEKNE-KCVLYWPEK-RGIYGKVEVLVISVNECDNYTIRNLVL 535
+MVW++ S IVM+T+L+EK+ KC YWP + YG ++V ++ E + +R L
Sbjct: 1477 RMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSL 1536
Query: 536 KQG--SHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIG 593
+ S + V+ + +T+WPDH P+ P L + V+ GP+VVHCSAG+G
Sbjct: 1537 HKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN--PPDAGPIVVHCSAGVG 1594
Query: 594 RTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
RTGCFI +++K E VD V +R R MVQT +QY F+H AL
Sbjct: 1595 RTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1645
Score = 168 bits (426), Expect = 1e-41
Identities = 92/241 (38%), Positives = 138/241 (57%), Gaps = 6/241 (2%)
Query: 411 DIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMI 470
++P + KNR I+P +RVCL+P + S YINA++I GY ++KA+IATQGP+
Sbjct: 1701 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFIDGYR-QQKAYIATQGPLA 1758
Query: 471 NTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRGI-YGKVEVLVISVNECDNY 528
T +DFW+M+W+ +S ++VM+TKL+E EKC YWP +R Y V ++ Y
Sbjct: 1759 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1818
Query: 529 TIRNLVLKQGSHTQH--VKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVV 586
+R + Q V+ + +T WP+ P S + + + V + + GP+ V
Sbjct: 1819 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1878
Query: 587 HCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCL 646
HCSAG+GRTG FI SI ++++ EGVVD V LR R MVQT ++Y+F + A
Sbjct: 1879 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1938
Query: 647 Y 647
Y
Sbjct: 1939 Y 1939
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 172 bits (436), Expect = 9e-43
Identities = 104/256 (40%), Positives = 145/256 (56%), Gaps = 16/256 (6%)
Query: 408 KEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIR-------GYSGKEK 460
KE + KNRYK ILP +RV L + + +S YINAN I S +K
Sbjct: 266 KEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKK 325
Query: 461 AFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRGI--YGKVEV 517
++IATQG + NTV+DFW+MV+QE+S VIVM TK E+ + KCV YWP++ + YG + V
Sbjct: 326 SYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRV 385
Query: 518 LVISVNECDNYTIRNLVLK---QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEED 574
+ + +YT+R L L QG+ + V Y + +WPDH P +L + +V
Sbjct: 386 RNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHK 445
Query: 575 RLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGV---VDALSIVCQLRMDRGGMV 631
+ + GPVVVHCSAGIGRTG FI I ++E+GV +D + +R R GMV
Sbjct: 446 QESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMV 505
Query: 632 QTSEQYEFVHHALCLY 647
QT QY F++ A+ Y
Sbjct: 506 QTEAQYRFIYMAVQHY 521
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 169 bits (428), Expect = 7e-42
Identities = 93/241 (38%), Positives = 138/241 (57%), Gaps = 6/241 (2%)
Query: 411 DIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMI 470
++P + KNR I+P +RVCL+P + S YINA++I GY ++KA+IATQGP+
Sbjct: 1255 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFIDGYR-QQKAYIATQGPLA 1312
Query: 471 NTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRGI-YGKVEVLVISVNECDNY 528
T +DFW+M+W+ +S ++VM+TKL+E EKC YWP +R Y V ++ Y
Sbjct: 1313 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1372
Query: 529 TIRNLVLKQGSHTQH--VKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVV 586
+R + Q V+ + +T WP+ P S + + + V + + GP+ V
Sbjct: 1373 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1432
Query: 587 HCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCL 646
HCSAG+GRTG FI SI ++++ EGVVD V LR R MVQT +QY+F + A
Sbjct: 1433 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE 1492
Query: 647 Y 647
Y
Sbjct: 1493 Y 1493
Score = 168 bits (425), Expect = 2e-41
Identities = 95/231 (41%), Positives = 132/231 (57%), Gaps = 8/231 (3%)
Query: 418 KNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFW 477
KNRY ++ SRV L S Y+NANYI GY K+ A+IATQG + T DFW
Sbjct: 973 KNRYANVIAYDHSRVLLSAIEGIPG-SDYVNANYIDGYR-KQNAYIATQGSLPETFGDFW 1030
Query: 478 QMVWQEDSPVIVMITKLKEKNE-KCVLYWPEK-RGIYGKVEVLVISVNECDNYTIRNLVL 535
+M+W++ S +VM+TKL+E++ KC YWP + +G V+V ++ E Y +R L
Sbjct: 1031 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1090
Query: 536 -KQGS-HTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIG 593
K GS + V+ + +T+WPDH P+ P L + V+ GP+VVHCSAG+G
Sbjct: 1091 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCN--PPDAGPMVVHCSAGVG 1148
Query: 594 RTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL 644
RTGCFI +++K E VD V +R R MVQT +QY F+H AL
Sbjct: 1149 RTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1199
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,569,899
Number of Sequences: 37866
Number of extensions: 1097128
Number of successful extensions: 3305
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2712
Number of HSP's gapped (non-prelim): 178
length of query: 657
length of database: 18,247,518
effective HSP length: 109
effective length of query: 548
effective length of database: 14,120,124
effective search space: 7737827952
effective search space used: 7737827952
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.