Search of human proteins with 4506203

Search of human proteins with 4506203

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]
         (277 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]        553   e-158
gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]       326   2e-89
gi|23110925 proteasome beta 6 subunit [Homo sapiens]                  103   2e-22
gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo...    92   5e-19
gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo ...    92   5e-19
gi|153791216 proteasome beta 11 subunit [Homo sapiens]                 89   4e-18
gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens]          87   2e-17
gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Hom...    82   5e-16
gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo...    82   5e-16
gi|195539356 proteasome beta 5 subunit isoform 2 [Homo sapiens]        60   2e-09
gi|222144262 proteasome beta 5 subunit isoform 3 [Homo sapiens]        58   1e-08
gi|23110942 proteasome alpha 5 subunit [Homo sapiens]                  49   4e-06
gi|4506193 proteasome beta 1 subunit [Homo sapiens]                    49   5e-06
gi|4506195 proteasome beta 2 subunit [Homo sapiens]                    46   4e-05
gi|22538465 proteasome beta 3 subunit [Homo sapiens]                   44   1e-04
gi|22538467 proteasome beta 4 subunit [Homo sapiens]                   43   3e-04
gi|4506189 proteasome alpha 7 subunit [Homo sapiens]                   42   5e-04
gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]         33   0.27 
gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens]        33   0.27 
gi|48762932 chaperonin containing TCP1, subunit 8 (theta) [Homo ...    32   0.61 
gi|189011550 N-acylsphingosine amidohydrolase 1 isoform c [Homo ...    29   5.2  
gi|189011548 N-acylsphingosine amidohydrolase 1 isoform a prepro...    29   5.2  
gi|189011546 N-acylsphingosine amidohydrolase 1 isoform b [Homo ...    29   5.2  

>gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]
          Length = 277

 Score =  553 bits (1425), Expect = e-158
 Identities = 277/277 (100%), Positives = 277/277 (100%)

Query: 1   MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD 60
           MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD
Sbjct: 1   MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD 60

Query: 61  TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV 120
           TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV
Sbjct: 61  TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV 120

Query: 121 TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV 180
           TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV
Sbjct: 121 TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV 180

Query: 181 FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT 240
           FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT
Sbjct: 181 FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT 240

Query: 241 RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS 277
           RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
Sbjct: 241 RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS 277


>gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]
          Length = 273

 Score =  326 bits (835), Expect = 2e-89
 Identities = 155/266 (58%), Positives = 202/266 (75%), Gaps = 2/266 (0%)

Query: 10  PVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVV 69
           P GGFSF+NC+RNA LE      G K+P  RKTGTTIAG+V++DG++LGADTRAT   VV
Sbjct: 8   PRGGFSFENCQRNASLERVLP--GLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVV 65

Query: 70  ADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQM 129
           ADK+C KIHFI+P IYCCGAG AAD +MTT++++S +ELH+LSTGR PRV T  R+L+Q 
Sbjct: 66  ADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQT 125

Query: 130 LFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDM 189
           LFRYQG++GA+L++GGVD+TGP LY ++PHGS  +LP+  +GSG  AA+AV ED+F+P+M
Sbjct: 126 LFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNM 185

Query: 190 EEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEK 249
             E A+ L+ EA+ AGI  DLGSG N+D CVI+K     LR  + P +   R GRY    
Sbjct: 186 TLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVP 245

Query: 250 GTTAVLTEKITPLEIEVLEETVQTMD 275
           GTTAVLT+ + PL +E++EETVQ M+
Sbjct: 246 GTTAVLTQTVKPLTLELVEETVQAME 271


>gi|23110925 proteasome beta 6 subunit [Homo sapiens]
          Length = 239

 Score =  103 bits (257), Expect = 2e-22
 Identities = 60/187 (32%), Positives = 96/187 (51%), Gaps = 1/187 (0%)

Query: 42  TGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQL 101
           TGTTI  V +  G+VLGAD+R T G  +A++   K+  I   I+CC +G+AADT      
Sbjct: 33  TGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADA 92

Query: 102 ISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVD-VTGPHLYSIYPHG 160
           ++  L  HS+     P V TA  + K+M +RY+  + A +++ G D   G  +YS+   G
Sbjct: 93  VTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGG 152

Query: 161 STDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCV 220
              +  +   GSGS       +  +R  M +EE     + A+A  +  D  SG  I L  
Sbjct: 153 MMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAA 212

Query: 221 ISKNKLD 227
           I+++ ++
Sbjct: 213 IAESGVE 219


>gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo
           sapiens]
          Length = 209

 Score = 92.0 bits (227), Expect = 5e-19
 Identities = 55/187 (29%), Positives = 93/187 (49%), Gaps = 2/187 (1%)

Query: 42  TGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQL 101
           TGTTI  V +  G+V+G+D+R + G  V ++   K+  +   IYC  +G+AAD      +
Sbjct: 9   TGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADM 68

Query: 102 ISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDV-TGPHLYSIYPHG 160
            +  LELH +     P V+ A  +++ + ++Y+  + A L++ G D   G  +Y     G
Sbjct: 69  AAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTL-GG 127

Query: 161 STDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCV 220
              + P+   GSGS       +  ++P M  EE +   ++AIA  +  D  SG  I L  
Sbjct: 128 MLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVT 187

Query: 221 ISKNKLD 227
           I+   +D
Sbjct: 188 ITAAGVD 194


>gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo
           sapiens]
          Length = 219

 Score = 92.0 bits (227), Expect = 5e-19
 Identities = 55/187 (29%), Positives = 93/187 (49%), Gaps = 2/187 (1%)

Query: 42  TGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQL 101
           TGTTI  V +  G+V+G+D+R + G  V ++   K+  +   IYC  +G+AAD      +
Sbjct: 19  TGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADM 78

Query: 102 ISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDV-TGPHLYSIYPHG 160
            +  LELH +     P V+ A  +++ + ++Y+  + A L++ G D   G  +Y     G
Sbjct: 79  AAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTL-GG 137

Query: 161 STDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCV 220
              + P+   GSGS       +  ++P M  EE +   ++AIA  +  D  SG  I L  
Sbjct: 138 MLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVT 197

Query: 221 ISKNKLD 227
           I+   +D
Sbjct: 198 ITAAGVD 204


>gi|153791216 proteasome beta 11 subunit [Homo sapiens]
          Length = 300

 Score = 89.0 bits (219), Expect = 4e-18
 Identities = 56/177 (31%), Positives = 92/177 (51%), Gaps = 1/177 (0%)

Query: 43  GTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLI 102
           GTT     ++ G++  ADTR++ G  VA     K+  +  ++    +GT+AD     +++
Sbjct: 49  GTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVL 108

Query: 103 SSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGY-IGAALVLGGVDVTGPHLYSIYPHGS 161
              L L  L  G+LP V +A ++L  M+ +Y+G  +  A  L G D +GP L+ +Y  G+
Sbjct: 109 QRELRLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGT 168

Query: 162 TDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDL 218
             +    ++GSGS  A  V +  +R DM  +EA  L   A+A     D  SG ++DL
Sbjct: 169 RLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDL 225


>gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens]
          Length = 263

 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 51/177 (28%), Positives = 90/177 (50%), Gaps = 1/177 (0%)

Query: 43  GTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLI 102
           GTT     ++ G+++ AD+RAT G  +A +   K+  I+P +    AG AAD     +L+
Sbjct: 59  GTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLL 118

Query: 103 SSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGY-IGAALVLGGVDVTGPHLYSIYPHGS 161
           +    ++ L       V  A+++L  M+++Y+G  +    ++ G D  GP LY +   G+
Sbjct: 119 ARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGN 178

Query: 162 TDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDL 218
                  ++GSGS+ A  V +  +  D+E E+A +L   AI    + D  SG  ++L
Sbjct: 179 RISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNL 235


>gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Homo
           sapiens]
          Length = 276

 Score = 82.0 bits (201), Expect = 5e-16
 Identities = 50/177 (28%), Positives = 88/177 (49%), Gaps = 1/177 (0%)

Query: 43  GTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLI 102
           GTT     ++ G++   D+RA+ G  ++    +K+  I+P +    +G AAD     +L+
Sbjct: 72  GTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLL 131

Query: 103 SSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGY-IGAALVLGGVDVTGPHLYSIYPHGS 161
           +    L+ L  G    V  A+++L  M+ +Y+G  +    ++ G D  GP LY +  HG+
Sbjct: 132 AKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGT 191

Query: 162 TDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDL 218
                  + GSG+  A  V +  +RP++  EEA +L   AIA     D  SG  +++
Sbjct: 192 RLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNM 248


>gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo
           sapiens]
          Length = 272

 Score = 82.0 bits (201), Expect = 5e-16
 Identities = 50/177 (28%), Positives = 88/177 (49%), Gaps = 1/177 (0%)

Query: 43  GTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLI 102
           GTT     ++ G++   D+RA+ G  ++    +K+  I+P +    +G AAD     +L+
Sbjct: 68  GTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLL 127

Query: 103 SSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGY-IGAALVLGGVDVTGPHLYSIYPHGS 161
           +    L+ L  G    V  A+++L  M+ +Y+G  +    ++ G D  GP LY +  HG+
Sbjct: 128 AKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGT 187

Query: 162 TDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDL 218
                  + GSG+  A  V +  +RP++  EEA +L   AIA     D  SG  +++
Sbjct: 188 RLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNM 244


>gi|195539356 proteasome beta 5 subunit isoform 2 [Homo sapiens]
          Length = 160

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 37/131 (28%), Positives = 65/131 (49%), Gaps = 1/131 (0%)

Query: 89  AGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGY-IGAALVLGGVD 147
           AG AAD     +L++    ++ L       V  A+++L  M+++Y+G  +    ++ G D
Sbjct: 2   AGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWD 61

Query: 148 VTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIF 207
             GP LY +   G+       ++GSGS+ A  V +  +  D+E E+A +L   AI    +
Sbjct: 62  KRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATY 121

Query: 208 NDLGSGSNIDL 218
            D  SG  ++L
Sbjct: 122 RDAYSGGAVNL 132


>gi|222144262 proteasome beta 5 subunit isoform 3 [Homo sapiens]
          Length = 203

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 31/110 (28%), Positives = 57/110 (51%), Gaps = 1/110 (0%)

Query: 43  GTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLI 102
           GTT     ++ G+++ AD+RAT G  +A +   K+  I+P +    AG AAD     +L+
Sbjct: 59  GTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLL 118

Query: 103 SSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGY-IGAALVLGGVDVTGP 151
           +    ++ L       V  A+++L  M+++Y+G  +    ++ G D  GP
Sbjct: 119 ARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGP 168


>gi|23110942 proteasome alpha 5 subunit [Homo sapiens]
          Length = 241

 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 42/191 (21%), Positives = 77/191 (40%), Gaps = 12/191 (6%)

Query: 41  KTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQ 100
           K G+T  G+   +G+ L  + R T  ++    +  KI  I  +I C  +G  AD      
Sbjct: 32  KLGSTAIGIQTSEGVCLAVEKRITSPLM-EPSSIEKIVEIDAHIGCAMSGLIADAKTLID 90

Query: 101 LISSNLELHSLSTGRLPRVVTANRMLKQMLFRY----------QGYIGAALVLGGVDVTG 150
                 + H  +      V +  + +  +  ++              G AL+ GGVD  G
Sbjct: 91  KARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKG 150

Query: 151 PHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDL 210
           P L+ + P G+  +     +GS S  A +  ++ +   M  +EA    S  I   +  + 
Sbjct: 151 PQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIK-SSLIILKQVMEEK 209

Query: 211 GSGSNIDLCVI 221
            + +NI+L  +
Sbjct: 210 LNATNIELATV 220


>gi|4506193 proteasome beta 1 subunit [Homo sapiens]
          Length = 241

 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 44/208 (21%), Positives = 91/208 (43%), Gaps = 16/208 (7%)

Query: 43  GTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLI 102
           G TI  +  +D  ++ +DTR +EG  +  ++  K + ++       +G   D    T++I
Sbjct: 37  GGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKII 96

Query: 103 SSNLELHSLSTGRLPRVVTANRMLKQMLF--RYQGYIGAALVLGGVDVTGP-HLYSIYPH 159
            + L+++  S  +         ML  +L+  R+  Y     ++GG+D  G   +YS  P 
Sbjct: 97  EARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYY-VYNIIGGLDEEGKGAVYSFDPV 155

Query: 160 GSTDKLPYVTMGSGSLAAMAVFEDKF---------RPDMEEEEAKNLVSEAIAAGIFNDL 210
           GS  +  +   GS S     + +++             +  + A  LV +   +    D+
Sbjct: 156 GSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDV 215

Query: 211 GSGSNIDLCVISKNKLDFLRPYTVPNKK 238
            +G  + +C+++K   + +R  TV  +K
Sbjct: 216 YTGDALRICIVTK---EGIREETVSLRK 240


>gi|4506195 proteasome beta 2 subunit [Homo sapiens]
          Length = 201

 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 37/161 (22%), Positives = 67/161 (41%), Gaps = 4/161 (2%)

Query: 46  IAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSN 105
           + G+   D +++ +D  A   +V    +  K+  +S  I     G A DT    + I  N
Sbjct: 4   LIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKN 63

Query: 106 LELHSLSTG-RLPRVVTAN---RMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGS 161
           ++L+ +  G  L     AN   R L   L     Y    L+ G  +  GP LY +    +
Sbjct: 64  VQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAA 123

Query: 162 TDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAI 202
             K P+   G G+   +++ +  + P +  E A  L+ + +
Sbjct: 124 LAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCL 164


>gi|22538465 proteasome beta 3 subunit [Homo sapiens]
          Length = 205

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 43/190 (22%), Positives = 80/190 (42%), Gaps = 8/190 (4%)

Query: 43  GTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLI 102
           G  +  +  K+ + + AD R      +   +  KI  +   +Y   AG A D     Q +
Sbjct: 8   GGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRL 67

Query: 103 SSNLELHSLSTGRLPRVVTANRMLKQMLFRYQ-GYIGAALVLGGVD--VTGPHLYSIYPH 159
              L L+ L  GR  +  T   M+  +L+  + G      V+ G+D     P + S+   
Sbjct: 68  KFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLI 127

Query: 160 GS---TDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNI 216
           G    TD   +V  G+ +     + E  + P+M+ +     +S+A+   +  D  SG  +
Sbjct: 128 GCPMVTDD--FVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAVSGMGV 185

Query: 217 DLCVISKNKL 226
            + +I K+K+
Sbjct: 186 IVHIIEKDKI 195


>gi|22538467 proteasome beta 4 subunit [Homo sapiens]
          Length = 264

 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 39/198 (19%), Positives = 86/198 (43%), Gaps = 10/198 (5%)

Query: 42  TGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQL 101
           TGT++ GV ++ G+V+ AD   + G +   +N S+I  ++ +     +G  AD     Q+
Sbjct: 52  TGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQV 111

Query: 102 ISSNL---ELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGA---ALVLGGVDVTGPHLYS 155
           +   +   EL        PR +  +  L + ++  +  +      +V+GG       L  
Sbjct: 112 LGQMVIDEELLGDGHSYSPRAI--HSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGY 169

Query: 156 IYPHGSTDKLPYVTMGSGSLAAMAVFED--KFRPDMEEEEAKNLVSEAIAAGIFNDLGSG 213
           +   G   + P +  G G+  A  +  +  + +P + + EA++LV   +    + D  S 
Sbjct: 170 VDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSY 229

Query: 214 SNIDLCVISKNKLDFLRP 231
           +   +  +++  ++   P
Sbjct: 230 NRFQIATVTEKGVEIEGP 247


>gi|4506189 proteasome alpha 7 subunit [Homo sapiens]
          Length = 248

 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 46/199 (23%), Positives = 81/199 (40%), Gaps = 11/199 (5%)

Query: 41  KTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQ 100
           K G+T  GV  +D +VLG + ++    +  ++   KI  +  N+    AG  AD  +   
Sbjct: 27  KKGSTAVGVRGRDIVVLGVEKKSV-AKLQDERTVRKICALDDNVCMAFAGLTADARIVIN 85

Query: 101 LISSNLELHSLSTGRLPRVVTANRMLKQMLFRY-----QGYIGAALVLGGVDVTG-PHLY 154
                 + H L+      V    R +  +  RY     +   G + ++ G D  G P LY
Sbjct: 86  RARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLY 145

Query: 155 SIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGS-G 213
              P G+        +G G+ +     E  +    E  E  +L  + +   +   + S G
Sbjct: 146 QTDPSGTYHAWKANAIGRGAKSVREFLEKNYTD--EAIETDDLTIKLVIKALLEVVQSGG 203

Query: 214 SNIDLCVISKNK-LDFLRP 231
            NI+L V+ +++ L  L P
Sbjct: 204 KNIELAVMRRDQSLKILNP 222


>gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]
          Length = 263

 Score = 33.1 bits (74), Expect = 0.27
 Identities = 37/156 (23%), Positives = 60/156 (38%), Gaps = 10/156 (6%)

Query: 41  KTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTD---- 96
           K G+   G+  K   VL A  RA   +    K   KI  +  +I    AG  AD      
Sbjct: 30  KQGSATVGLKSKTHAVLVALKRAQSELAAHQK---KILHVDNHIGISIAGLTADARLLCN 86

Query: 97  -MTTQLISSNLEL-HSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLY 154
            M  + + S       L   RL  ++ +   +    +  + Y G  L++ G D  GPH++
Sbjct: 87  FMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPY-GVGLLIAGYDDMGPHIF 145

Query: 155 SIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDME 190
              P  +      +++G+ S +A    E      ME
Sbjct: 146 QTCPSANYFDCRAMSIGARSQSARTYLERHMSEFME 181


>gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens]
          Length = 269

 Score = 33.1 bits (74), Expect = 0.27
 Identities = 37/156 (23%), Positives = 60/156 (38%), Gaps = 10/156 (6%)

Query: 41  KTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTD---- 96
           K G+   G+  K   VL A  RA   +    K   KI  +  +I    AG  AD      
Sbjct: 36  KQGSATVGLKSKTHAVLVALKRAQSELAAHQK---KILHVDNHIGISIAGLTADARLLCN 92

Query: 97  -MTTQLISSNLEL-HSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLY 154
            M  + + S       L   RL  ++ +   +    +  + Y G  L++ G D  GPH++
Sbjct: 93  FMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPY-GVGLLIAGYDDMGPHIF 151

Query: 155 SIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDME 190
              P  +      +++G+ S +A    E      ME
Sbjct: 152 QTCPSANYFDCRAMSIGARSQSARTYLERHMSEFME 187


>gi|48762932 chaperonin containing TCP1, subunit 8 (theta) [Homo
           sapiens]
          Length = 548

 Score = 32.0 bits (71), Expect = 0.61
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 3/42 (7%)

Query: 65  EGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNL 106
           EG  +A   C K H I PN+ CC A    D D  + L+ +++
Sbjct: 130 EGYEIA---CRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSI 168


>gi|189011550 N-acylsphingosine amidohydrolase 1 isoform c [Homo
           sapiens]
          Length = 389

 Score = 28.9 bits (63), Expect = 5.2
 Identities = 17/49 (34%), Positives = 30/49 (61%), Gaps = 1/49 (2%)

Query: 192 EEAKNLVSEA-IAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKG 239
           EEAKNL+++  I A  +  LG   + + CVI++++ + L  Y +  K+G
Sbjct: 258 EEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQG 306


>gi|189011548 N-acylsphingosine amidohydrolase 1 isoform a
           preproprotein [Homo sapiens]
          Length = 395

 Score = 28.9 bits (63), Expect = 5.2
 Identities = 17/49 (34%), Positives = 30/49 (61%), Gaps = 1/49 (2%)

Query: 192 EEAKNLVSEA-IAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKG 239
           EEAKNL+++  I A  +  LG   + + CVI++++ + L  Y +  K+G
Sbjct: 264 EEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQG 312


>gi|189011546 N-acylsphingosine amidohydrolase 1 isoform b [Homo
           sapiens]
          Length = 411

 Score = 28.9 bits (63), Expect = 5.2
 Identities = 17/49 (34%), Positives = 30/49 (61%), Gaps = 1/49 (2%)

Query: 192 EEAKNLVSEA-IAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKG 239
           EEAKNL+++  I A  +  LG   + + CVI++++ + L  Y +  K+G
Sbjct: 280 EEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQG 328


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,506,298
Number of Sequences: 37866
Number of extensions: 380703
Number of successful extensions: 795
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 769
Number of HSP's gapped (non-prelim): 23
length of query: 277
length of database: 18,247,518
effective HSP length: 101
effective length of query: 176
effective length of database: 14,423,052
effective search space: 2538457152
effective search space used: 2538457152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.