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Search of human proteins with 4506091
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens]
(721 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens] 1469 0.0
gi|89276769 mitogen-activated protein kinase 4 [Homo sapiens] 582 e-166
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 274 2e-73
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 274 2e-73
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 270 3e-72
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 255 9e-68
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 251 1e-66
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 228 1e-59
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 228 1e-59
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 228 1e-59
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 217 3e-56
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 214 2e-55
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 211 1e-54
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 206 8e-53
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 203 5e-52
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 200 4e-51
gi|149408126 nemo like kinase [Homo sapiens] 194 2e-49
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 184 2e-46
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 184 2e-46
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s... 181 2e-45
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 174 3e-43
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 174 3e-43
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 174 3e-43
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 174 3e-43
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 174 3e-43
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 172 1e-42
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 172 1e-42
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 170 4e-42
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 170 4e-42
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 169 8e-42
>gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens]
Length = 721
Score = 1469 bits (3802), Expect = 0.0
Identities = 721/721 (100%), Positives = 721/721 (100%)
Query: 1 MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVK 60
MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVK
Sbjct: 1 MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVK 60
Query: 61 HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE 120
HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE
Sbjct: 61 HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE 120
Query: 121 QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP 180
QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP
Sbjct: 121 QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP 180
Query: 181 HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ 240
HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ
Sbjct: 181 HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ 240
Query: 241 MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFS 300
MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFS
Sbjct: 241 MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFS 300
Query: 301 PMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDC 360
PMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDC
Sbjct: 301 PMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDC 360
Query: 361 QFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYS 420
QFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYS
Sbjct: 361 QFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYS 420
Query: 421 TEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWK 480
TEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWK
Sbjct: 421 TEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWK 480
Query: 481 EQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQ 540
EQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQ
Sbjct: 481 EQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQ 540
Query: 541 HEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSG 600
HEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSG
Sbjct: 541 HEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSG 600
Query: 601 GEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEG 660
GEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEG
Sbjct: 601 GEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEG 660
Query: 661 FLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHL 720
FLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHL
Sbjct: 661 FLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHL 720
Query: 721 N 721
N
Sbjct: 721 N 721
>gi|89276769 mitogen-activated protein kinase 4 [Homo sapiens]
Length = 587
Score = 582 bits (1500), Expect = e-166
Identities = 323/589 (54%), Positives = 398/589 (67%), Gaps = 55/589 (9%)
Query: 1 MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVK 60
MAEK + + +++G+DLG R++D +PLG G NGLV SAVD+ ++VA+KKI L+D +S+K
Sbjct: 1 MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMK 60
Query: 61 HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE 120
HALREIKIIRRLDHDNIVKV+E+LGP G TD G L + + YIVQEYMETDLA +LE
Sbjct: 61 HALREIKIIRRLDHDNIVKVYEVLGPKG---TDLQGELFKFSVAYIVQEYMETDLARLLE 117
Query: 121 QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP 180
QG L EEHA+LFMYQLLRGLKYIHSANVLHRDLKPAN+FI+TEDLVLKIGDFGLARI+D
Sbjct: 118 QGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQ 177
Query: 181 HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ 240
HYSHKG+LSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCI AEMLTG+ LFAGAHELEQ
Sbjct: 178 HYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQ 237
Query: 241 MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFS 300
MQLILE+IPV+ EED+ ELL V+P ++ + E +PL +LLP ++ EA+DFLE+ILTF+
Sbjct: 238 MQLILETIPVIREEDKDELLRVMPSFV-SSTWEVKRPLRKLLPEVNSEAIDFLEKILTFN 296
Query: 301 PMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWE----R 356
PMDRLTAE L HPYMS YS P DEP S HPF IEDE+DDI+LM S + NW+ R
Sbjct: 297 PMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSR 356
Query: 357 YHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFD 416
Y S+ +W D EVQ DPRA E+VQVDPRK E++LE
Sbjct: 357 YPVSLSSDLEWRPDRCQDASEVQRDPRA-GSAPLAEDVQVDPRKDSHSSSERFLEQ---- 411
Query: 417 TNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDL 476
S + + + +C+YK S SYLD L+WR+++ +HY EPKLI+DL
Sbjct: 412 -----------SHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDL 460
Query: 477 SNWKE------------QSKEKSDKKGKSKCERNGLVKA-QIALEEASQQLAGKEREKNQ 523
S+WK+ + + D+ E VK+ Q E AS ER +
Sbjct: 461 SHWKQAAGAPPTATGLADTGAREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSA 520
Query: 524 G---------------FDFDSFIAGTIQLSSQHEPTDVVD-KLNDLNSS 556
FD D FI+ ++L + +P D+ D KL DLN +
Sbjct: 521 SPPGRPAPVDGGASPQFDLDVFISRALKLCT--KPEDLPDNKLGDLNGA 567
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 274 bits (700), Expect = 2e-73
Identities = 152/334 (45%), Positives = 214/334 (64%), Gaps = 20/334 (5%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSV-KHALREIKIIRRL 72
FD+G RY +L +G G G+V SA DN RVAIKKI + Q+ + LREIKI+ R
Sbjct: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRF 78
Query: 73 DHDNIVKVFEIL-GPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
H+NI+ + +I+ P+ Q+ D VYIVQ+ METDL +L+ L +H
Sbjct: 79 RHENIIGINDIIRAPTIEQMKD----------VYIVQDLMETDLYKLLKTQHLSNDHICY 128
Query: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
F+YQ+LRGLKYIHSANVLHRDLKP+NL +NT LKI DFGLAR+ DP + H G L+E
Sbjct: 129 FLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARVADPDHDHTGFLTEY 187
Query: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
+ T+WYR+P ++L+ YTK+ID+W+ GCI AEML+ + +F G H L+Q+ IL ++
Sbjct: 188 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL---GIL 244
Query: 252 HEEDRQELLSVIPVYIRNDMTE-PHK---PLTQLLPGISREALDFLEQILTFSPMDRLTA 307
+++L +I + RN + PHK P +L P +ALD L+++LTF+P R+
Sbjct: 245 GSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEV 304
Query: 308 EEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDI 341
E+AL+HPY+ Y P DEPI+ PF + E+DD+
Sbjct: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDL 338
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 274 bits (700), Expect = 2e-73
Identities = 152/334 (45%), Positives = 214/334 (64%), Gaps = 20/334 (5%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSV-KHALREIKIIRRL 72
FD+G RY +L +G G G+V SA DN RVAIKKI + Q+ + LREIKI+ R
Sbjct: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRF 78
Query: 73 DHDNIVKVFEIL-GPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
H+NI+ + +I+ P+ Q+ D VYIVQ+ METDL +L+ L +H
Sbjct: 79 RHENIIGINDIIRAPTIEQMKD----------VYIVQDLMETDLYKLLKTQHLSNDHICY 128
Query: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
F+YQ+LRGLKYIHSANVLHRDLKP+NL +NT LKI DFGLAR+ DP + H G L+E
Sbjct: 129 FLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARVADPDHDHTGFLTEY 187
Query: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
+ T+WYR+P ++L+ YTK+ID+W+ GCI AEML+ + +F G H L+Q+ IL ++
Sbjct: 188 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL---GIL 244
Query: 252 HEEDRQELLSVIPVYIRNDMTE-PHK---PLTQLLPGISREALDFLEQILTFSPMDRLTA 307
+++L +I + RN + PHK P +L P +ALD L+++LTF+P R+
Sbjct: 245 GSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEV 304
Query: 308 EEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDI 341
E+AL+HPY+ Y P DEPI+ PF + E+DD+
Sbjct: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDL 338
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 270 bits (690), Expect = 3e-72
Identities = 147/330 (44%), Positives = 211/330 (63%), Gaps = 12/330 (3%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSV-KHALREIKIIRRL 72
FD+G RY L+ +G G G+V SA D+ RVAIKKI + Q+ + LREI+I+ R
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95
Query: 73 DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLF 132
H+N++ + +IL S +L + VYIVQ+ METDL +L+ L +H F
Sbjct: 96 RHENVIGIRDILRAS---------TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYF 146
Query: 133 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGL 192
+YQ+LRGLKYIHSANVLHRDLKP+NL INT LKI DFGLARI DP + H G L+E +
Sbjct: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYV 205
Query: 193 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 252
T+WYR+P ++L+ YTK+ID+W+ GCI AEML+ + +F G H L+Q+ IL +
Sbjct: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265
Query: 253 EEDRQELLSV-IPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEAL 311
+ED ++++ Y+++ ++ +L P +ALD L+++LTF+P R+T EEAL
Sbjct: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325
Query: 312 SHPYMSIYSFPMDEPISSHPFHIEDEVDDI 341
+HPY+ Y P DEP++ PF E+DD+
Sbjct: 326 AHPYLEQYYDPTDEPVAEEPFTFAMELDDL 355
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 255 bits (652), Expect = 9e-68
Identities = 141/314 (44%), Positives = 201/314 (64%), Gaps = 12/314 (3%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSV-KHALREIKIIRRL 72
FD+G RY L+ +G G G+V SA D+ RVAIKKI + Q+ + LREI+I+ R
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95
Query: 73 DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLF 132
H+N++ + +IL S +L + VYIVQ+ METDL +L+ L +H F
Sbjct: 96 RHENVIGIRDILRAS---------TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYF 146
Query: 133 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGL 192
+YQ+LRGLKYIHSANVLHRDLKP+NL INT LKI DFGLARI DP + H G L+E +
Sbjct: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYV 205
Query: 193 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 252
T+WYR+P ++L+ YTK+ID+W+ GCI AEML+ + +F G H L+Q+ IL +
Sbjct: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265
Query: 253 EEDRQELLSV-IPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEAL 311
+ED ++++ Y+++ ++ +L P +ALD L+++LTF+P R+T EEAL
Sbjct: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325
Query: 312 SHPYMSIYSFPMDE 325
+HPY+ Y P DE
Sbjct: 326 AHPYLEQYYDPTDE 339
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 251 bits (642), Expect = 1e-66
Identities = 142/329 (43%), Positives = 193/329 (58%), Gaps = 54/329 (16%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSV-KHALREIKIIRRL 72
FD+G RY L+ +G G G+V SA D+ RVAIKKI + Q+ + LREI+I+ R
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95
Query: 73 DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLF 132
H+N++ + +IL S +L + VYIVQ+ METDL +L+ L +H F
Sbjct: 96 RHENVIGIRDILRAS---------TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYF 146
Query: 133 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGL 192
+YQ+LRGLKYIHSANVLHRDLKP+NL INT LKI DFGLARI DP + H G L+E +
Sbjct: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYV 205
Query: 193 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 252
T+WYR+P ++L+ YTK+ID+W+ GCI AEML+ + +F G H L+Q+ IL
Sbjct: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL------- 258
Query: 253 EEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALS 312
ALD L+++LTF+P R+T EEAL+
Sbjct: 259 ------------------------------------ALDLLDRMLTFNPNKRITVEEALA 282
Query: 313 HPYMSIYSFPMDEPISSHPFHIEDEVDDI 341
HPY+ Y P DEP++ PF E+DD+
Sbjct: 283 HPYLEQYYDPTDEPVAEEPFTFAMELDDL 311
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 228 bits (582), Expect = 1e-59
Identities = 138/330 (41%), Positives = 197/330 (59%), Gaps = 26/330 (7%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI-----VLTDPQSVKHALREIKI 68
FD+G Y ++ +G G G+V SA ++VAIKKI V+T+ K LRE+KI
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTN---AKRTLRELKI 105
Query: 69 IRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQG-PLLEE 127
++ HDNI+ + +IL P T G E SVY+V + ME+DL ++ PL E
Sbjct: 106 LKHFKHDNIIAIKDILRP-----TVPYG---EFKSVYVVLDLMESDLHQIIHSSQPLTLE 157
Query: 128 HARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLAR-IMDPHYSHKG 186
H R F+YQLLRGLKY+HSA V+HRDLKP+NL +N E+ LKIGDFG+AR + H+
Sbjct: 158 HVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQY 216
Query: 187 HLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILE 246
++E + T+WYR+P L+LS + YT+AID+W+ GCIF EML + LF G + + Q+QLI+
Sbjct: 217 FMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMM 276
Query: 247 SI----PVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPM 302
+ P V + E + YI++ P + PG R+AL L ++L F P
Sbjct: 277 VLGTPSPAVIQAVGAER---VRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPS 333
Query: 303 DRLTAEEALSHPYMSIYSFPMDEPISSHPF 332
R++A AL HP+++ Y P DEP + PF
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF 363
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 228 bits (582), Expect = 1e-59
Identities = 138/330 (41%), Positives = 197/330 (59%), Gaps = 26/330 (7%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI-----VLTDPQSVKHALREIKI 68
FD+G Y ++ +G G G+V SA ++VAIKKI V+T+ K LRE+KI
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTN---AKRTLRELKI 105
Query: 69 IRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQG-PLLEE 127
++ HDNI+ + +IL P T G E SVY+V + ME+DL ++ PL E
Sbjct: 106 LKHFKHDNIIAIKDILRP-----TVPYG---EFKSVYVVLDLMESDLHQIIHSSQPLTLE 157
Query: 128 HARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLAR-IMDPHYSHKG 186
H R F+YQLLRGLKY+HSA V+HRDLKP+NL +N E+ LKIGDFG+AR + H+
Sbjct: 158 HVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQY 216
Query: 187 HLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILE 246
++E + T+WYR+P L+LS + YT+AID+W+ GCIF EML + LF G + + Q+QLI+
Sbjct: 217 FMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMM 276
Query: 247 SI----PVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPM 302
+ P V + E + YI++ P + PG R+AL L ++L F P
Sbjct: 277 VLGTPSPAVIQAVGAER---VRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPS 333
Query: 303 DRLTAEEALSHPYMSIYSFPMDEPISSHPF 332
R++A AL HP+++ Y P DEP + PF
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF 363
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 228 bits (582), Expect = 1e-59
Identities = 138/330 (41%), Positives = 197/330 (59%), Gaps = 26/330 (7%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI-----VLTDPQSVKHALREIKI 68
FD+G Y ++ +G G G+V SA ++VAIKKI V+T+ K LRE+KI
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTN---AKRTLRELKI 105
Query: 69 IRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQG-PLLEE 127
++ HDNI+ + +IL P T G E SVY+V + ME+DL ++ PL E
Sbjct: 106 LKHFKHDNIIAIKDILRP-----TVPYG---EFKSVYVVLDLMESDLHQIIHSSQPLTLE 157
Query: 128 HARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLAR-IMDPHYSHKG 186
H R F+YQLLRGLKY+HSA V+HRDLKP+NL +N E+ LKIGDFG+AR + H+
Sbjct: 158 HVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQY 216
Query: 187 HLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILE 246
++E + T+WYR+P L+LS + YT+AID+W+ GCIF EML + LF G + + Q+QLI+
Sbjct: 217 FMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMM 276
Query: 247 SI----PVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPM 302
+ P V + E + YI++ P + PG R+AL L ++L F P
Sbjct: 277 VLGTPSPAVIQAVGAER---VRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPS 333
Query: 303 DRLTAEEALSHPYMSIYSFPMDEPISSHPF 332
R++A AL HP+++ Y P DEP + PF
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF 363
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 217 bits (552), Expect = 3e-56
Identities = 129/345 (37%), Positives = 204/345 (59%), Gaps = 24/345 (6%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA---LREIKII 69
+++ RY +L P+G G G V +A D RVA+KK L+ P QS+ HA RE++++
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK--LSRPFQSIIHAKRTYRELRLL 75
Query: 70 RRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHA 129
+ + H+N++ + ++ P+ S L E N VY+V M DL N+++ L ++H
Sbjct: 76 KHMKHENVIGLLDVFTPARS--------LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 130 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 189
+ +YQ+LRGLKYIHSA+++HRDLKP+NL +N ED LKI DFGLAR D ++
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTD------DEMT 180
Query: 190 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIP 249
+ T+WYR+P ++L+ +Y + +D+W+ GCI AE+LTG+TLF G ++Q++LIL +
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
Query: 250 VVHEEDRQELLS-VIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAE 308
E +++ S YI++ P + G + A+D LE++L R+TA
Sbjct: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300
Query: 309 EALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYN 353
+AL+H Y + Y P DEP++ P+ E D LL+DE S Y+
Sbjct: 301 QALAHAYFAQYHDPDDEPVAD-PYDQSFESRD-LLIDEWKSLTYD 343
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 214 bits (545), Expect = 2e-55
Identities = 131/348 (37%), Positives = 196/348 (56%), Gaps = 22/348 (6%)
Query: 9 MNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSV--KHALREI 66
+N ++L Y+ +G G G V SA+D ++VAIKK+ + K A RE+
Sbjct: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73
Query: 67 KIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLE 126
+++ + H+N++ + ++ P+ S L Y+V +M+TDL ++ E
Sbjct: 74 LLLKHMQHENVIGLLDVFTPASS--------LRNFYDFYLVMPFMQTDLQKIMGM-EFSE 124
Query: 127 EHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKG 186
E + +YQ+L+GLKYIHSA V+HRDLKP NL +N ED LKI DFGLAR D
Sbjct: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLARHAD------A 177
Query: 187 HLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILE 246
++ +VT+WYR+P ++LS +Y + +D+W+ GCI AEMLTGKTLF G L+Q+ IL+
Sbjct: 178 EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237
Query: 247 SIPVVHEEDRQELL-SVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRL 305
V E Q+L YI++ P K TQL P S +A D LE++L RL
Sbjct: 238 VTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL 297
Query: 306 TAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVD-DILLMDETHSHIY 352
TA +AL+HP+ + P +E + PF +D ++ + L +DE HIY
Sbjct: 298 TAAQALTHPFFEPFRDPEEETEAQQPF--DDSLEHEKLTVDEWKQHIY 343
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 211 bits (538), Expect = 1e-54
Identities = 129/346 (37%), Positives = 200/346 (57%), Gaps = 26/346 (7%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA---LREIKII 69
+++ RY +L P+G G G V +A D RVA+KK L+ P QS+ HA RE++++
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK--LSRPFQSIIHAKRTYRELRLL 75
Query: 70 RRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHA 129
+ + H+N++ + ++ P+ S L E N VY+V M DL N+++ L ++H
Sbjct: 76 KHMKHENVIGLLDVFTPARS--------LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 130 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 189
+ +YQ+LRGLKYIHSA+++HRDLKP+NL +N ED LKI DFGLAR D ++
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTD------DEMT 180
Query: 190 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLI--LES 247
+ T+WYR+P ++L+ +Y + +D+W+ GCI AE+LTG+TLF G + Q+Q I L
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 240
Query: 248 IPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTA 307
P + +R YI++ P + G + A+D LE++L R+TA
Sbjct: 241 TPPAYLINRMPSHEA-RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA 299
Query: 308 EEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYN 353
+AL+H Y + Y P DEP++ P+ E D LL+DE S Y+
Sbjct: 300 AQALAHAYFAQYHDPDDEPVAD-PYDQSFESRD-LLIDEWKSLTYD 343
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 206 bits (523), Expect = 8e-53
Identities = 121/315 (38%), Positives = 182/315 (57%), Gaps = 21/315 (6%)
Query: 19 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREIKIIRRL-DHD 75
RY+ + LG G G+V+ AVD + VAIKKI D + REI +++ DH
Sbjct: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHP 71
Query: 76 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEE-HARLFMY 134
NI+ + +++ + +Y+V E+M+TDL V+ +G LL++ H R Y
Sbjct: 72 NIISLLDVIRAENDR------------DIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFY 119
Query: 135 QLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMD--PHYSHKGHLSEGL 192
QLLR +++HS +V+HRD KP+N+ ++ + +K+ DFGLAR + P ++E +
Sbjct: 120 QLLRATRFLHSGHVVHRDQKPSNVLLDA-NCTVKLCDFGLARSLGDLPEGPEDQAVTEYV 178
Query: 193 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 252
T+WYR+P +LLS + YT +DMW+ GCI EML G+ LF G L Q++LILE+IP
Sbjct: 179 ATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPS 238
Query: 253 EEDRQELLSVIPVYIRNDM-TEPHKPLTQLL-PGISREALDFLEQILTFSPMDRLTAEEA 310
EED L S + + + + P + L LL P S EALD L ++L F+P RL+A +A
Sbjct: 239 EEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQA 298
Query: 311 LSHPYMSIYSFPMDE 325
L HPY+ + P DE
Sbjct: 299 LQHPYVQRFHCPSDE 313
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 203 bits (516), Expect = 5e-52
Identities = 117/318 (36%), Positives = 189/318 (59%), Gaps = 22/318 (6%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA---LREIKII 69
+++ R L+P+G G G V SA D ++VA+KK L+ P QS+ HA RE++++
Sbjct: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKK--LSRPFQSLIHARRTYRELRLL 75
Query: 70 RRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHA 129
+ L H+N++ + ++ P+ S + + + VY+V M DL N+++ L +EH
Sbjct: 76 KHLKHENVIGLLDVFTPATS--------IEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
Query: 130 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 189
+ +YQLLRGLKYIHSA ++HRDLKP+N+ +N ED L+I DFGLAR D ++
Sbjct: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLARQADE------EMT 180
Query: 190 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIP 249
+ T+WYR+P ++L+ +Y + +D+W+ GCI AE+L GK LF G+ ++Q++ I+E +
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240
Query: 250 VVHEEDRQELLSV-IPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAE 308
E ++ S YI++ P K L+ + G + A+D L ++L R++A
Sbjct: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300
Query: 309 EALSHPYMSIYSFPMDEP 326
EAL+H Y S Y P DEP
Sbjct: 301 EALAHAYFSQYHDPEDEP 318
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 200 bits (508), Expect = 4e-51
Identities = 117/325 (36%), Positives = 181/325 (55%), Gaps = 21/325 (6%)
Query: 20 YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSV--KHALREIKIIRRLDHDNI 77
Y DL+P+G G G V SAVD +VAIKK+ + K A RE+++++ + H+N+
Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86
Query: 78 VKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLL 137
+ + ++ P + L + Y+V +M TDL +++ L E+ + +YQ+L
Sbjct: 87 IGLLDVFTPDET--------LDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQML 138
Query: 138 RGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWY 197
+GL+YIH+A ++HRDLKP NL +N ED LKI DFGLAR D ++ +VT+WY
Sbjct: 139 KGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLARQAD------SEMTGYVVTRWY 191
Query: 198 RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ 257
R+P ++L+ YT+ +D+W+ GCI AEM+TGKTLF G+ L+Q++ I++ E Q
Sbjct: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251
Query: 258 ELLS-VIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM 316
L S Y++ K +L S A++ LE++L R+TA EAL+HPY
Sbjct: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311
Query: 317 SIYSFPMDEPISSHPFHIEDEVDDI 341
DEP +D DD+
Sbjct: 312 ESLHDTEDEP---QVQKYDDSFDDV 333
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 194 bits (494), Expect = 2e-49
Identities = 109/298 (36%), Positives = 176/298 (59%), Gaps = 17/298 (5%)
Query: 24 KPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREIKIIRRLDHDNIVKVF 81
+P+G G G+V+S D KRVA+KK+ V + S K RE+K++ HDN++
Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
Query: 82 EILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVL-EQGPLLEEHARLFMYQLLRGL 140
+IL P + +Y+V E M++DL ++ PL +H ++F+YQ+LRGL
Sbjct: 202 DILQPP---------HIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGL 252
Query: 141 KYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSP 200
KY+HSA +LHRD+KP NL +N+ + VLKI DFGLAR+ + S H+++ +VT++YR+P
Sbjct: 253 KYLHSAGILHRDIKPGNLLVNS-NCVLKICDFGLARVEELDESR--HMTQEVVTQYYRAP 309
Query: 201 RLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELL 260
+L+ +Y+ AID+W+ GCIFAE+L + LF ++Q+ LI + + E +
Sbjct: 310 EILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTAC 369
Query: 261 SVIPVYI-RNDMTEPHKPLTQLLPG-ISREALDFLEQILTFSPMDRLTAEEALSHPYM 316
+I R +P P+ L + EA+ L ++L F P R++A++AL+HPY+
Sbjct: 370 EGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL 427
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 184 bits (468), Expect = 2e-46
Identities = 97/239 (40%), Positives = 153/239 (64%), Gaps = 21/239 (8%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA---LREIKII 69
+++ RY +L P+G G G V +A D RVA+KK L+ P QS+ HA RE++++
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK--LSRPFQSIIHAKRTYRELRLL 75
Query: 70 RRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHA 129
+ + H+N++ + ++ P+ S L E N VY+V M DL N+++ L ++H
Sbjct: 76 KHMKHENVIGLLDVFTPARS--------LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 130 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 189
+ +YQ+LRGLKYIHSA+++HRDLKP+NL +N ED LKI DFGLAR D ++
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTD------DEMT 180
Query: 190 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESI 248
+ T+WYR+P ++L+ +Y + +D+W+ GCI AE+LTG+TLF G ++Q++LIL +
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239
>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
Length = 307
Score = 184 bits (468), Expect = 2e-46
Identities = 97/239 (40%), Positives = 153/239 (64%), Gaps = 21/239 (8%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA---LREIKII 69
+++ RY +L P+G G G V +A D RVA+KK L+ P QS+ HA RE++++
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK--LSRPFQSIIHAKRTYRELRLL 75
Query: 70 RRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHA 129
+ + H+N++ + ++ P+ S L E N VY+V M DL N+++ L ++H
Sbjct: 76 KHMKHENVIGLLDVFTPARS--------LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 130 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 189
+ +YQ+LRGLKYIHSA+++HRDLKP+NL +N ED LKI DFGLAR D ++
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTD------DEMT 180
Query: 190 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESI 248
+ T+WYR+P ++L+ +Y + +D+W+ GCI AE+LTG+TLF G ++Q++LIL +
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239
>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
sapiens]
Length = 677
Score = 181 bits (459), Expect = 2e-45
Identities = 100/228 (43%), Positives = 142/228 (62%), Gaps = 10/228 (4%)
Query: 111 METDLANVLEQG-PLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKI 169
ME+DL ++ PL EH R F+YQLLRGLKY+HSA V+HRDLKP+NL +N E+ LKI
Sbjct: 1 MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKI 59
Query: 170 GDFGLAR-IMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTG 228
GDFG+AR + H+ ++E + T+WYR+P L+LS + YT+AID+W+ GCIF EML
Sbjct: 60 GDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLAR 119
Query: 229 KTLFAGAHELEQMQLILESI----PVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPG 284
+ LF G + + Q+QLI+ + P V + E + YI++ P + PG
Sbjct: 120 RQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAER---VRAYIQSLPPRQPVPWETVYPG 176
Query: 285 ISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPF 332
R+AL L ++L F P R++A AL HP+++ Y P DEP + PF
Sbjct: 177 ADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPF 224
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 174 bits (441), Expect = 3e-43
Identities = 110/356 (30%), Positives = 185/356 (51%), Gaps = 36/356 (10%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRR 71
F + RY +LKP+G G G+V +A D D+ VAIKK+ + K A RE+ +++
Sbjct: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117
Query: 72 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
++H NI+ + + P + L E VY+V E M+ +L V++ L E
Sbjct: 118 VNHKNIISLLNVFTPQKT--------LEEFQDVYLVMELMDANLCQVIQM-ELDHERMSY 168
Query: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
+YQ+L G+K++HSA ++HRDLKP+N+ + + D LKI DFGLAR + ++
Sbjct: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFM----MTPY 223
Query: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
+VT++YR+P ++L Y + +D+W+ GCI EM+ K LF G ++Q ++E +
Sbjct: 224 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282
Query: 252 HEEDRQELLSVIPVYIRN-----DMTEPHKPLTQLLPGISR-------EALDFLEQILTF 299
E ++L + Y+ N +T P L P S +A D L ++L
Sbjct: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342
Query: 300 SPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWE 355
P R++ ++AL HPY++++ P + + + P I D+ +DE I W+
Sbjct: 343 DPAKRISVDDALQHPYINVWYDPAE--VEAPPPQIYDK-----QLDEREHTIEEWK 391
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 174 bits (441), Expect = 3e-43
Identities = 110/356 (30%), Positives = 185/356 (51%), Gaps = 36/356 (10%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRR 71
F + RY +LKP+G G G+V +A D D+ VAIKK+ + K A RE+ +++
Sbjct: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117
Query: 72 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
++H NI+ + + P + L E VY+V E M+ +L V++ L E
Sbjct: 118 VNHKNIISLLNVFTPQKT--------LEEFQDVYLVMELMDANLCQVIQM-ELDHERMSY 168
Query: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
+YQ+L G+K++HSA ++HRDLKP+N+ + + D LKI DFGLAR + ++
Sbjct: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFM----MTPY 223
Query: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
+VT++YR+P ++L Y + +D+W+ GCI EM+ K LF G ++Q ++E +
Sbjct: 224 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282
Query: 252 HEEDRQELLSVIPVYIRN-----DMTEPHKPLTQLLPGISR-------EALDFLEQILTF 299
E ++L + Y+ N +T P L P S +A D L ++L
Sbjct: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342
Query: 300 SPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWE 355
P R++ ++AL HPY++++ P + + + P I D+ +DE I W+
Sbjct: 343 DPAKRISVDDALQHPYINVWYDPAE--VEAPPPQIYDK-----QLDEREHTIEEWK 391
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 174 bits (441), Expect = 3e-43
Identities = 110/356 (30%), Positives = 185/356 (51%), Gaps = 36/356 (10%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRR 71
F + RY +LKP+G G G+V +A D D+ VAIKK+ + K A RE+ +++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 72 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
++H NI+ + + P + L E VY+V E M+ +L V++ L E
Sbjct: 80 VNHKNIISLLNVFTPQKT--------LEEFQDVYLVMELMDANLCQVIQM-ELDHERMSY 130
Query: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
+YQ+L G+K++HSA ++HRDLKP+N+ + + D LKI DFGLAR + ++
Sbjct: 131 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFM----MTPY 185
Query: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
+VT++YR+P ++L Y + +D+W+ GCI EM+ K LF G ++Q ++E +
Sbjct: 186 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 244
Query: 252 HEEDRQELLSVIPVYIRN-----DMTEPHKPLTQLLPGISR-------EALDFLEQILTF 299
E ++L + Y+ N +T P L P S +A D L ++L
Sbjct: 245 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 304
Query: 300 SPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWE 355
P R++ ++AL HPY++++ P + + + P I D+ +DE I W+
Sbjct: 305 DPAKRISVDDALQHPYINVWYDPAE--VEAPPPQIYDK-----QLDEREHTIEEWK 353
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 174 bits (440), Expect = 3e-43
Identities = 108/356 (30%), Positives = 182/356 (51%), Gaps = 36/356 (10%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRR 71
F + RY +LKP+G G G+V +A D ++ VAIKK+ + K A RE+ +++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 72 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
++H NI+ + + P S L E VYIV E M+ +L V++ L E
Sbjct: 80 VNHKNIIGLLNVFTPQKS--------LEEFQDVYIVMELMDANLCQVIQM-ELDHERMSY 130
Query: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
+YQ+L G+K++HSA ++HRDLKP+N+ + + D LKI DFGLAR + ++
Sbjct: 131 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFM----MTPY 185
Query: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
+VT++YR+P ++L Y + +D+W+ GCI EM+ G LF G ++Q ++E +
Sbjct: 186 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTP 244
Query: 252 HEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGI------------SREALDFLEQILTF 299
E ++L + Y+ N +L P + + +A D L ++L
Sbjct: 245 CPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 304
Query: 300 SPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWE 355
R++ +EAL HPY++++ P + + P I D+ +DE I W+
Sbjct: 305 DASKRISVDEALQHPYINVWYDPSE--AEAPPPKIPDK-----QLDEREHTIEEWK 353
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 174 bits (440), Expect = 3e-43
Identities = 108/356 (30%), Positives = 182/356 (51%), Gaps = 36/356 (10%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRR 71
F + RY +LKP+G G G+V +A D ++ VAIKK+ + K A RE+ +++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 72 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
++H NI+ + + P S L E VYIV E M+ +L V++ L E
Sbjct: 80 VNHKNIIGLLNVFTPQKS--------LEEFQDVYIVMELMDANLCQVIQM-ELDHERMSY 130
Query: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
+YQ+L G+K++HSA ++HRDLKP+N+ + + D LKI DFGLAR + ++
Sbjct: 131 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFM----MTPY 185
Query: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
+VT++YR+P ++L Y + +D+W+ GCI EM+ G LF G ++Q ++E +
Sbjct: 186 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTP 244
Query: 252 HEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGI------------SREALDFLEQILTF 299
E ++L + Y+ N +L P + + +A D L ++L
Sbjct: 245 CPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 304
Query: 300 SPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWE 355
R++ +EAL HPY++++ P + + P I D+ +DE I W+
Sbjct: 305 DASKRISVDEALQHPYINVWYDPSE--AEAPPPKIPDK-----QLDEREHTIEEWK 353
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 172 bits (435), Expect = 1e-42
Identities = 108/356 (30%), Positives = 182/356 (51%), Gaps = 36/356 (10%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRR 71
F + RY +LKP+G G G+V +A D ++ VAIKK+ + K A RE+ +++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 72 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
++H NI+ + + P S L E VYIV E M+ +L V++ L E
Sbjct: 80 VNHKNIIGLLNVFTPQKS--------LEEFQDVYIVMELMDANLCQVIQM-ELDHERMSY 130
Query: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
+YQ+L G+K++HSA ++HRDLKP+N+ + + D LKI DFGLAR + ++
Sbjct: 131 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFM----MTPY 185
Query: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
+VT++YR+P ++L Y + +D+W+ GCI EM+ K LF G ++Q ++E +
Sbjct: 186 VVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTP 244
Query: 252 HEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGI------------SREALDFLEQILTF 299
E ++L + Y+ N +L P + + +A D L ++L
Sbjct: 245 CPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 304
Query: 300 SPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWE 355
R++ +EAL HPY++++ P + + P I D+ +DE I W+
Sbjct: 305 DASKRISVDEALQHPYINVWYDPSE--AEAPPPKIPDK-----QLDEREHTIEEWK 353
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 172 bits (435), Expect = 1e-42
Identities = 108/356 (30%), Positives = 182/356 (51%), Gaps = 36/356 (10%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRR 71
F + RY +LKP+G G G+V +A D ++ VAIKK+ + K A RE+ +++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 72 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
++H NI+ + + P S L E VYIV E M+ +L V++ L E
Sbjct: 80 VNHKNIIGLLNVFTPQKS--------LEEFQDVYIVMELMDANLCQVIQM-ELDHERMSY 130
Query: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
+YQ+L G+K++HSA ++HRDLKP+N+ + + D LKI DFGLAR + ++
Sbjct: 131 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFM----MTPY 185
Query: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
+VT++YR+P ++L Y + +D+W+ GCI EM+ K LF G ++Q ++E +
Sbjct: 186 VVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTP 244
Query: 252 HEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGI------------SREALDFLEQILTF 299
E ++L + Y+ N +L P + + +A D L ++L
Sbjct: 245 CPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 304
Query: 300 SPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWE 355
R++ +EAL HPY++++ P + + P I D+ +DE I W+
Sbjct: 305 DASKRISVDEALQHPYINVWYDPSE--AEAPPPKIPDK-----QLDEREHTIEEWK 353
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 170 bits (431), Expect = 4e-42
Identities = 101/325 (31%), Positives = 170/325 (52%), Gaps = 29/325 (8%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRR 71
F + RY LKP+G G G+V +A D VA+KK+ + K A RE+ +++
Sbjct: 20 FTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKC 79
Query: 72 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
++H NI+ + + P + L E VY+V E M+ +L V+ L E
Sbjct: 80 VNHKNIISLLNVFTPQKT--------LEEFQDVYLVMELMDANLCQVIHM-ELDHERMSY 130
Query: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
+YQ+L G+K++HSA ++HRDLKP+N+ + + D LKI DFGLAR ++ ++
Sbjct: 131 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTACTNFM----MTPY 185
Query: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
+VT++YR+P ++L Y + +D+W+ GCI AEM+ K LF G ++Q ++E +
Sbjct: 186 VVTRYYRAPEVILGMG-YKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTP 244
Query: 252 HEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPG------------ISREALDFLEQILTF 299
E ++L + Y+ N P +L P + +A D L ++L
Sbjct: 245 SAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 304
Query: 300 SPMDRLTAEEALSHPYMSIYSFPMD 324
P R++ +EAL HPY++++ P +
Sbjct: 305 DPDKRISVDEALRHPYITVWYDPAE 329
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 170 bits (431), Expect = 4e-42
Identities = 101/325 (31%), Positives = 170/325 (52%), Gaps = 29/325 (8%)
Query: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRR 71
F + RY LKP+G G G+V +A D VA+KK+ + K A RE+ +++
Sbjct: 20 FTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKC 79
Query: 72 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
++H NI+ + + P + L E VY+V E M+ +L V+ L E
Sbjct: 80 VNHKNIISLLNVFTPQKT--------LEEFQDVYLVMELMDANLCQVIHM-ELDHERMSY 130
Query: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
+YQ+L G+K++HSA ++HRDLKP+N+ + + D LKI DFGLAR ++ ++
Sbjct: 131 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTACTNFM----MTPY 185
Query: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
+VT++YR+P ++L Y + +D+W+ GCI AEM+ K LF G ++Q ++E +
Sbjct: 186 VVTRYYRAPEVILGMG-YKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTP 244
Query: 252 HEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPG------------ISREALDFLEQILTF 299
E ++L + Y+ N P +L P + +A D L ++L
Sbjct: 245 SAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 304
Query: 300 SPMDRLTAEEALSHPYMSIYSFPMD 324
P R++ +EAL HPY++++ P +
Sbjct: 305 DPDKRISVDEALRHPYITVWYDPAE 329
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 169 bits (428), Expect = 8e-42
Identities = 112/356 (31%), Positives = 180/356 (50%), Gaps = 49/356 (13%)
Query: 19 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQS--VKHALREIKIIRRLDHDN 76
+Y L +G G +G+VF A + + VA+KK+ L + ALREIK ++ ++ +
Sbjct: 3 QYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQ 62
Query: 77 IVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE--QGPLLEEHARLFMY 134
V + + P G + E+M +DLA V+ Q PL + + ++
Sbjct: 63 YVVQLKAVFPHGGGFV-------------LAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQ 109
Query: 135 QLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPH----YSHKGHLSE 190
LL+G+ + H+ N++HRDLKPANL I+ LKI DFGLAR+ P Y+H+
Sbjct: 110 MLLKGVAFCHANNIVHRDLKPANLLISASGQ-LKIADFGLARVFSPDGSRLYTHQ----- 163
Query: 191 GLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPV 250
+ T+WYR+P LL Y + +D+W+ GCI E+L G LF G +++EQ+ +L +
Sbjct: 164 -VATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGT 222
Query: 251 VHEEDRQELLSVIPVYIRNDMTEP-HKPLTQLLPGISREALDFLEQILTFSPMDRLTAEE 309
+ + E L+ +P Y + E PL ++LP +S +ALD L Q L + P R+ A +
Sbjct: 223 PNPQVWPE-LTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASK 281
Query: 310 ALSHPYM---SIYSFPMDEPISS----------------HPFHIEDEVDDILLMDE 346
AL H Y + + P + PI H FH++ +++ LL E
Sbjct: 282 ALLHQYFFTAPLPAHPSELPIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPE 337
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,821,196
Number of Sequences: 37866
Number of extensions: 1288599
Number of successful extensions: 5991
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 565
Number of HSP's successfully gapped in prelim test: 219
Number of HSP's that attempted gapping in prelim test: 3868
Number of HSP's gapped (non-prelim): 1100
length of query: 721
length of database: 18,247,518
effective HSP length: 110
effective length of query: 611
effective length of database: 14,082,258
effective search space: 8604259638
effective search space used: 8604259638
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.