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Search of human proteins with 4506085
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
(365 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 738 0.0
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 481 e-136
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 450 e-126
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 445 e-125
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 442 e-124
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 375 e-104
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 351 7e-97
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 327 8e-90
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 327 8e-90
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 322 4e-88
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 322 4e-88
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 321 6e-88
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 321 6e-88
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 321 6e-88
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 321 6e-88
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 321 6e-88
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 320 1e-87
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 320 1e-87
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 298 4e-81
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 294 7e-80
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 294 7e-80
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 281 5e-76
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 281 5e-76
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 281 5e-76
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 279 2e-75
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 253 1e-67
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 239 2e-63
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 228 7e-60
gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ... 226 2e-59
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s... 220 2e-57
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 738 bits (1904), Expect = 0.0
Identities = 365/365 (100%), Positives = 365/365 (100%)
Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60
MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF
Sbjct: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60
Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM 120
QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM
Sbjct: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM 120
Query: 121 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT 180
EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT
Sbjct: 121 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT 180
Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240
GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG
Sbjct: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240
Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300
VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA
Sbjct: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300
Query: 301 QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRR 360
QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRR
Sbjct: 301 QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRR 360
Query: 361 SGMKL 365
SGMKL
Sbjct: 361 SGMKL 365
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 481 bits (1239), Expect = e-136
Identities = 233/347 (67%), Positives = 281/347 (80%), Gaps = 2/347 (0%)
Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65
+ GFY+Q+V KTAWE+ Y VGSGAYG+VCSA+D R+G KVAIKKL RPFQSE+F
Sbjct: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67
Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSE 124
AKRAYREL LLKHM+HENVIGLLDVFTP +L +F DFYLVMPFM TDL K+M E E
Sbjct: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127
Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 184
++IQ+LVYQMLKGL+YIH+AG++HRDLKPGNLAVNEDCELKILDFGLAR AD+EMTGYVV
Sbjct: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187
Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244
TRWYRAPEVIL+WM Y QTVDIWSVGCIMAEM+TGKTLFKG D+LDQL +I+KVTG P
Sbjct: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247
Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304
EFVQ+L AK+Y++ LP+ +KDF + ASP A +LLEKML LD ++R+TA +AL
Sbjct: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307
Query: 305 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
HP+FE D E+E + Q+ +DDS + T+DEWK+ YKE+++F P
Sbjct: 308 HPYFESLHDTEDEPQVQK-YDDSFDDVDRTLDEWKRVTYKEVLSFKP 353
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 450 bits (1157), Expect = e-126
Identities = 214/344 (62%), Positives = 270/344 (78%), Gaps = 2/344 (0%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY+Q++NKT WE+P+ Y + + VGSGAYGSVC+A D ++G +VA+KKLSRPFQS I AKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKI 127
YREL LLKHM+HENVIGLLDVFTPA SL F D YLV M DL I+ + +++ +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW 187
Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EMTGYV TRW
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 187
Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247
YRAPE++L+WMHYNQTVDIWSVGCIMAE+LTG+TLF G D++DQL IL++ G PG E +
Sbjct: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247
Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307
+K++ ++A++YIQSL Q P+ +F +F A+P A DLLEKML LD DKR+TAAQAL H +
Sbjct: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307
Query: 308 FEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
F + DP++E A P+D S E L +DEWK Y E+++F P
Sbjct: 308 FAQYHDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVP 350
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 445 bits (1144), Expect = e-125
Identities = 210/347 (60%), Positives = 275/347 (79%), Gaps = 2/347 (0%)
Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65
+ GFY+Q++NKT WE+P+ VGSGAYGSVCSA D R +KVA+KKLSRPFQS I
Sbjct: 5 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 64
Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSE 124
A+R YREL LLKH++HENVIGLLDVFTPA+S+ +F + YLV M DL I+ + S+
Sbjct: 65 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD 124
Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 184
E +Q+LVYQ+L+GLKYIHSAG++HRDLKP N+AVNEDCEL+ILDFGLAR AD EMTGYV
Sbjct: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVA 184
Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244
TRWYRAPE++L+WMHYNQTVDIWSVGCIMAE+L GK LF G DY+DQL +I++V G P
Sbjct: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244
Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304
E + K++ + A++YIQSLP P+KD + +F A+P A DLL +ML LD D+R++AA+AL
Sbjct: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304
Query: 305 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
H +F + DPE+E EA +P+D+S+E ++ T++EWK+ Y+E+++F P
Sbjct: 305 HAYFSQYHDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFKP 350
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 442 bits (1138), Expect = e-124
Identities = 211/344 (61%), Positives = 266/344 (77%), Gaps = 2/344 (0%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY+Q++NKT WE+P+ Y + + VGSGAYGSVC+A D ++G +VA+KKLSRPFQS I AKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKI 127
YREL LLKHM+HENVIGLLDVFTPA SL F D YLV M DL I+ + +++ +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW 187
Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EMTGYV TRW
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 187
Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247
YRAPE++L+WMHYNQTVDIWSVGCIMAE+LTG+TLF G D+++QL QI+++TG P +
Sbjct: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLI 247
Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307
++ A++YIQSL Q P+ +F +F A+P A DLLEKML LD DKR+TAAQAL H +
Sbjct: 248 NRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307
Query: 308 FEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
F + DP++E A P+D S E L +DEWK Y E+++F P
Sbjct: 308 FAQYHDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVP 350
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 375 bits (963), Expect = e-104
Identities = 176/272 (64%), Positives = 222/272 (81%), Gaps = 1/272 (0%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY+Q++NKT WE+P+ Y + + VGSGAYGSVC+A D ++G +VA+KKLSRPFQS I AKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKI 127
YREL LLKHM+HENVIGLLDVFTPA SL F D YLV M DL I+ + +++ +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW 187
Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EMTGYV TRW
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 187
Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247
YRAPE++L+WMHYNQTVDIWSVGCIMAE+LTG+TLF G D++DQL IL++ G PG E +
Sbjct: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247
Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASP 279
+K++ ++A++YIQSL Q P+ +F +F A+P
Sbjct: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANP 279
>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
Length = 307
Score = 351 bits (900), Expect = 7e-97
Identities = 164/247 (66%), Positives = 204/247 (82%), Gaps = 1/247 (0%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY+Q++NKT WE+P+ Y + + VGSGAYGSVC+A D ++G +VA+KKLSRPFQS I AKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKI 127
YREL LLKHM+HENVIGLLDVFTPA SL F D YLV M DL I+ + +++ +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW 187
Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EMTGYV TRW
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 187
Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247
YRAPE++L+WMHYNQTVDIWSVGCIMAE+LTG+TLF G D++DQL IL++ G PG E +
Sbjct: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247
Query: 248 QKLNDKA 254
+K++ ++
Sbjct: 248 KKISSES 254
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 327 bits (839), Expect = 8e-90
Identities = 172/356 (48%), Positives = 234/356 (65%), Gaps = 17/356 (4%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY V + + + K Y +GSGA G VC+A D G VA+KKLSRPFQ++ AKR
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128
AYREL+LLK + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMS 129
Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTR 186
YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A + MT YVVTR
Sbjct: 130 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTR 189
Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
+YRAPEVIL M Y + VDIWSVGCIMAEM+ K LF G+DY+DQ ++++ G P EF
Sbjct: 190 YYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPR------------ASPQAADLLEKMLELDVD 294
++KL ++Y+++ P+ P F +LFP + QA DLL KML +D D
Sbjct: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 295 KRLTAAQALTHPFFEPFRDP-EEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349
KR++ +AL HP+ + DP E E Q +D LE + ++EWK+ IYKE++++
Sbjct: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 327 bits (839), Expect = 8e-90
Identities = 172/356 (48%), Positives = 234/356 (65%), Gaps = 17/356 (4%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY V + + + K Y +GSGA G VC+A D G VA+KKLSRPFQ++ AKR
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128
AYREL+LLK + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMS 129
Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTR 186
YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A + MT YVVTR
Sbjct: 130 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTR 189
Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
+YRAPEVIL M Y + VDIWSVGCIMAEM+ K LF G+DY+DQ ++++ G P EF
Sbjct: 190 YYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPR------------ASPQAADLLEKMLELDVD 294
++KL ++Y+++ P+ P F +LFP + QA DLL KML +D D
Sbjct: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 295 KRLTAAQALTHPFFEPFRDP-EEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349
KR++ +AL HP+ + DP E E Q +D LE + ++EWK+ IYKE++++
Sbjct: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 322 bits (824), Expect = 4e-88
Identities = 168/356 (47%), Positives = 233/356 (65%), Gaps = 17/356 (4%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY V + + + K Y +GSGA G VC+A D G VA+KKLSRPFQ++ AKR
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128
AYREL+LLK + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMS 129
Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTR 186
YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A + MT YVVTR
Sbjct: 130 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTR 189
Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
+YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G D++DQ ++++ G P EF
Sbjct: 190 YYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPR------------ASPQAADLLEKMLELDVD 294
++KL ++Y+++ P+ P F +LFP + QA DLL KML +D D
Sbjct: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 295 KRLTAAQALTHPFFEPFRDP-EEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349
KR++ +AL HP+ + DP E E Q +D LE + ++EWK+ IYKE++++
Sbjct: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 322 bits (824), Expect = 4e-88
Identities = 168/356 (47%), Positives = 233/356 (65%), Gaps = 17/356 (4%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY V + + + K Y +GSGA G VC+A D G VA+KKLSRPFQ++ AKR
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128
AYREL+LLK + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMS 129
Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTR 186
YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A + MT YVVTR
Sbjct: 130 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTR 189
Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
+YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G D++DQ ++++ G P EF
Sbjct: 190 YYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPR------------ASPQAADLLEKMLELDVD 294
++KL ++Y+++ P+ P F +LFP + QA DLL KML +D D
Sbjct: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 295 KRLTAAQALTHPFFEPFRDP-EEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349
KR++ +AL HP+ + DP E E Q +D LE + ++EWK+ IYKE++++
Sbjct: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 321 bits (823), Expect = 6e-88
Identities = 169/360 (46%), Positives = 233/360 (64%), Gaps = 19/360 (5%)
Query: 5 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64
R FY ++ + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++
Sbjct: 6 RDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQT 65
Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124
AKRAYREL+L+K + H+N+IGLL+VFTP SL F D Y+VM M +L +++ ME
Sbjct: 66 HAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDH 125
Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGY 182
E++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT Y
Sbjct: 126 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 185
Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242
VVTR+YRAPEVIL M Y + VD+WSVGCIM EM+ K LF G+DY+DQ ++++ G P
Sbjct: 186 VVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTP 244
Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLE 290
EF++KL ++Y+++ P+ F +LFP + QA DLL KML
Sbjct: 245 CPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLV 303
Query: 291 LDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPF--DDSLEHEKLTVDEWKQHIYKEIVN 348
+D KR++ +AL HP+ + DP E EA P D L+ + T++EWK+ IYKE+++
Sbjct: 304 IDASKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 321 bits (823), Expect = 6e-88
Identities = 169/360 (46%), Positives = 233/360 (64%), Gaps = 19/360 (5%)
Query: 5 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64
R FY ++ + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++
Sbjct: 6 RDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQT 65
Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124
AKRAYREL+L+K + H+N+IGLL+VFTP SL F D Y+VM M +L +++ ME
Sbjct: 66 HAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDH 125
Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGY 182
E++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT Y
Sbjct: 126 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 185
Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242
VVTR+YRAPEVIL M Y + VD+WSVGCIM EM+ K LF G+DY+DQ ++++ G P
Sbjct: 186 VVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTP 244
Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLE 290
EF++KL ++Y+++ P+ F +LFP + QA DLL KML
Sbjct: 245 CPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLV 303
Query: 291 LDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPF--DDSLEHEKLTVDEWKQHIYKEIVN 348
+D KR++ +AL HP+ + DP E EA P D L+ + T++EWK+ IYKE+++
Sbjct: 304 IDASKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 321 bits (823), Expect = 6e-88
Identities = 169/355 (47%), Positives = 231/355 (65%), Gaps = 17/355 (4%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY +V + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ AKR
Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128
AYREL+L+K + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++
Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS 167
Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTR 186
YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR
Sbjct: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227
Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G+DY+DQ ++++ G P EF
Sbjct: 228 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLELDVD 294
++KL ++Y+++ P+ F +LFP + + QA DLL KML +D
Sbjct: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
Query: 295 KRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348
KR++ AL HP+ + DP E E Q +D L+ + T++EWK+ IYKE++N
Sbjct: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 321 bits (823), Expect = 6e-88
Identities = 169/355 (47%), Positives = 231/355 (65%), Gaps = 17/355 (4%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY +V + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ AKR
Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128
AYREL+L+K + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++
Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS 167
Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTR 186
YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR
Sbjct: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227
Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G+DY+DQ ++++ G P EF
Sbjct: 228 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLELDVD 294
++KL ++Y+++ P+ F +LFP + + QA DLL KML +D
Sbjct: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
Query: 295 KRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348
KR++ AL HP+ + DP E E Q +D L+ + T++EWK+ IYKE++N
Sbjct: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 321 bits (823), Expect = 6e-88
Identities = 169/355 (47%), Positives = 231/355 (65%), Gaps = 17/355 (4%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY +V + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ AKR
Sbjct: 10 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 69
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128
AYREL+L+K + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++
Sbjct: 70 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS 129
Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTR 186
YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR
Sbjct: 130 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 189
Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G+DY+DQ ++++ G P EF
Sbjct: 190 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 248
Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLELDVD 294
++KL ++Y+++ P+ F +LFP + + QA DLL KML +D
Sbjct: 249 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 307
Query: 295 KRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348
KR++ AL HP+ + DP E E Q +D L+ + T++EWK+ IYKE++N
Sbjct: 308 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 362
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 320 bits (820), Expect = 1e-87
Identities = 169/360 (46%), Positives = 232/360 (64%), Gaps = 19/360 (5%)
Query: 5 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64
R FY ++ + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++
Sbjct: 6 RDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQT 65
Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124
AKRAYREL+L+K + H+N+IGLL+VFTP SL F D Y+VM M +L +++ ME
Sbjct: 66 HAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDH 125
Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGY 182
E++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT Y
Sbjct: 126 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 185
Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242
VVTR+YRAPEVIL M Y + VDIWSVGCIM EM+ G LF G D++DQ ++++ G P
Sbjct: 186 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTP 244
Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLE 290
EF++KL ++Y+++ P+ F +LFP + QA DLL KML
Sbjct: 245 CPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLV 303
Query: 291 LDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPF--DDSLEHEKLTVDEWKQHIYKEIVN 348
+D KR++ +AL HP+ + DP E EA P D L+ + T++EWK+ IYKE+++
Sbjct: 304 IDASKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 320 bits (820), Expect = 1e-87
Identities = 169/360 (46%), Positives = 232/360 (64%), Gaps = 19/360 (5%)
Query: 5 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64
R FY ++ + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++
Sbjct: 6 RDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQT 65
Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124
AKRAYREL+L+K + H+N+IGLL+VFTP SL F D Y+VM M +L +++ ME
Sbjct: 66 HAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDH 125
Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGY 182
E++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT Y
Sbjct: 126 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 185
Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242
VVTR+YRAPEVIL M Y + VDIWSVGCIM EM+ G LF G D++DQ ++++ G P
Sbjct: 186 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTP 244
Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLE 290
EF++KL ++Y+++ P+ F +LFP + QA DLL KML
Sbjct: 245 CPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLV 303
Query: 291 LDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPF--DDSLEHEKLTVDEWKQHIYKEIVN 348
+D KR++ +AL HP+ + DP E EA P D L+ + T++EWK+ IYKE+++
Sbjct: 304 IDASKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 298 bits (764), Expect = 4e-81
Identities = 151/334 (45%), Positives = 219/334 (65%), Gaps = 9/334 (2%)
Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84
Y ++G GAYG V SA D +VAIKK+S PF+ + + +R RE+ +L +HENV
Sbjct: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV 100
Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSEEKIQYLVYQMLKGLKYIHS 143
IG+ D+ AS+L D Y+V M+TDL K++ + S + I Y +YQ+L+GLKYIHS
Sbjct: 101 IGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159
Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTRWYRAPEVILSW 197
A V+HRDLKP NL +N C+LKI DFGLAR AD E +T YV TRWYRAPE++L+
Sbjct: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219
Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257
Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P E + + + A++
Sbjct: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279
Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 317
Y+QSLP + + +LFP++ +A DLL++ML + +KR+T +AL HP+ E + DP +E
Sbjct: 280 YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDE 339
Query: 318 TEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
A++PF ++E + L + K+ I++E F P
Sbjct: 340 PVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 294 bits (753), Expect = 7e-80
Identities = 150/345 (43%), Positives = 221/345 (64%), Gaps = 9/345 (2%)
Query: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73
V +++ Y + +++G GAYG VCSA D + +VAIKK+S PF+ + + +R RE+
Sbjct: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVY 132
+L +HEN+IG+ D+ A ++ D Y+V M+TDL K++ + S + I Y +Y
Sbjct: 73 KILLRFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTR 186
Q+L+GLKYIHSA V+HRDLKP NL +N C+LKI DFGLAR AD + +T YV TR
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
WYRAPE++L+ Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P E
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306
+ + + A++Y+ SLP + + +LFP A +A DLL+KML + KR+ QAL HP
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 311
Query: 307 FFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
+ E + DP +E A+ PF +E + L ++ K+ I++E F P
Sbjct: 312 YLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 356
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 294 bits (753), Expect = 7e-80
Identities = 150/345 (43%), Positives = 221/345 (64%), Gaps = 9/345 (2%)
Query: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73
V +++ Y + +++G GAYG VCSA D + +VAIKK+S PF+ + + +R RE+
Sbjct: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVY 132
+L +HEN+IG+ D+ A ++ D Y+V M+TDL K++ + S + I Y +Y
Sbjct: 73 KILLRFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTR 186
Q+L+GLKYIHSA V+HRDLKP NL +N C+LKI DFGLAR AD + +T YV TR
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
WYRAPE++L+ Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P E
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306
+ + + A++Y+ SLP + + +LFP A +A DLL+KML + KR+ QAL HP
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 311
Query: 307 FFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
+ E + DP +E A+ PF +E + L ++ K+ I++E F P
Sbjct: 312 YLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 356
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 281 bits (720), Expect = 5e-76
Identities = 149/339 (43%), Positives = 211/339 (62%), Gaps = 11/339 (3%)
Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90
+G+GAYG V SA + +G++VAIKK+ F AKR REL +LKH +H+N+I + D+
Sbjct: 61 IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI 120
Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148
P F Y+V+ M++DL +I+ + E ++Y +YQ+L+GLKY+HSA V+H
Sbjct: 121 LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH 180
Query: 149 RDLKPGNLAVNEDCELKILDFGLARH---ADAE----MTGYVVTRWYRAPEVILSWMHYN 201
RDLKP NL VNE+CELKI DFG+AR + AE MT YV TRWYRAPE++LS Y
Sbjct: 181 RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT 240
Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261
Q +D+WSVGCI EML + LF GK+Y+ QL I+ V G P +Q + + ++YIQS
Sbjct: 241 QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS 300
Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQ 321
LP + ++P A QA LL +ML + R++AA AL HPF + DP++E +
Sbjct: 301 LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA 360
Query: 322 QPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRR 360
PFD + + E LT + K+ I EI +F AR++ R+
Sbjct: 361 PPFDFAFDREALTRERIKEAIVAEIEDFH--ARREGIRQ 397
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 281 bits (720), Expect = 5e-76
Identities = 149/339 (43%), Positives = 211/339 (62%), Gaps = 11/339 (3%)
Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90
+G+GAYG V SA + +G++VAIKK+ F AKR REL +LKH +H+N+I + D+
Sbjct: 61 IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI 120
Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148
P F Y+V+ M++DL +I+ + E ++Y +YQ+L+GLKY+HSA V+H
Sbjct: 121 LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH 180
Query: 149 RDLKPGNLAVNEDCELKILDFGLARH---ADAE----MTGYVVTRWYRAPEVILSWMHYN 201
RDLKP NL VNE+CELKI DFG+AR + AE MT YV TRWYRAPE++LS Y
Sbjct: 181 RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT 240
Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261
Q +D+WSVGCI EML + LF GK+Y+ QL I+ V G P +Q + + ++YIQS
Sbjct: 241 QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS 300
Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQ 321
LP + ++P A QA LL +ML + R++AA AL HPF + DP++E +
Sbjct: 301 LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA 360
Query: 322 QPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRR 360
PFD + + E LT + K+ I EI +F AR++ R+
Sbjct: 361 PPFDFAFDREALTRERIKEAIVAEIEDFH--ARREGIRQ 397
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 281 bits (720), Expect = 5e-76
Identities = 149/339 (43%), Positives = 211/339 (62%), Gaps = 11/339 (3%)
Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90
+G+GAYG V SA + +G++VAIKK+ F AKR REL +LKH +H+N+I + D+
Sbjct: 61 IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI 120
Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148
P F Y+V+ M++DL +I+ + E ++Y +YQ+L+GLKY+HSA V+H
Sbjct: 121 LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH 180
Query: 149 RDLKPGNLAVNEDCELKILDFGLARH---ADAE----MTGYVVTRWYRAPEVILSWMHYN 201
RDLKP NL VNE+CELKI DFG+AR + AE MT YV TRWYRAPE++LS Y
Sbjct: 181 RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT 240
Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261
Q +D+WSVGCI EML + LF GK+Y+ QL I+ V G P +Q + + ++YIQS
Sbjct: 241 QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS 300
Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQ 321
LP + ++P A QA LL +ML + R++AA AL HPF + DP++E +
Sbjct: 301 LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA 360
Query: 322 QPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRR 360
PFD + + E LT + K+ I EI +F AR++ R+
Sbjct: 361 PPFDFAFDREALTRERIKEAIVAEIEDFH--ARREGIRQ 397
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 279 bits (714), Expect = 2e-75
Identities = 141/300 (47%), Positives = 200/300 (66%), Gaps = 9/300 (3%)
Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84
Y ++G GAYG V SA D +VAIKK+S PF+ + + +R RE+ +L +HENV
Sbjct: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV 100
Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSEEKIQYLVYQMLKGLKYIHS 143
IG+ D+ AS+L D Y+V M+TDL K++ + S + I Y +YQ+L+GLKYIHS
Sbjct: 101 IGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159
Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTRWYRAPEVILSW 197
A V+HRDLKP NL +N C+LKI DFGLAR AD E +T YV TRWYRAPE++L+
Sbjct: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219
Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257
Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P E + + + A++
Sbjct: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279
Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 317
Y+QSLP + + +LFP++ +A DLL++ML + +KR+T +AL HP+ E + DP +E
Sbjct: 280 YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDE 339
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 253 bits (647), Expect = 1e-67
Identities = 139/334 (41%), Positives = 194/334 (58%), Gaps = 53/334 (15%)
Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84
Y ++G GAYG V SA D +VAIKK+S PF+ + + +R RE+ +L +HENV
Sbjct: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV 100
Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSEEKIQYLVYQMLKGLKYIHS 143
IG+ D+ AS+L D Y+V M+TDL K++ + S + I Y +YQ+L+GLKYIHS
Sbjct: 101 IGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159
Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTRWYRAPEVILSW 197
A V+HRDLKP NL +N C+LKI DFGLAR AD E +T YV TRWYRAPE++L+
Sbjct: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219
Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257
Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL
Sbjct: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL--------------------- 258
Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 317
A DLL++ML + +KR+T +AL HP+ E + DP +E
Sbjct: 259 -----------------------ALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDE 295
Query: 318 TEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
A++PF ++E + L + K+ I++E F P
Sbjct: 296 PVAEEPFTFAMELDDLPKERLKELIFQETARFQP 329
>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
[Homo sapiens]
Length = 242
Score = 239 bits (611), Expect = 2e-63
Identities = 122/221 (55%), Positives = 156/221 (70%), Gaps = 3/221 (1%)
Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
FY V + + + K Y +GSGA G VC+A D G VA+KKLSRPFQ++ AKR
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128
AYREL+LLK + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMS 129
Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTR 186
YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A + MT YVVTR
Sbjct: 130 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTR 189
Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD 227
+YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G D
Sbjct: 190 YYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTD 229
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 228 bits (581), Expect = 7e-60
Identities = 135/339 (39%), Positives = 192/339 (56%), Gaps = 19/339 (5%)
Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-QH 81
+ Y+ +G GAYG V A+D+R+GE VAIKK+ F+ + A+R +RE+ LL+ H
Sbjct: 11 RRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDH 70
Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLK 139
N+I LLDV N D YLV FM TDL ++ G + ++ + YQ+L+ +
Sbjct: 71 PNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATR 126
Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--------DAEMTGYVVTRWYRAP 191
++HS VVHRD KP N+ ++ +C +K+ DFGLAR D +T YV TRWYRAP
Sbjct: 127 FLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAP 186
Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251
EV+LS Y VD+WS+GCI+ EML G+ LF G L QL IL+ P E + L
Sbjct: 187 EVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALG 246
Query: 252 DKAAKSYIQSLPQTPRKDFTQLF-PRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310
S + L PR+ L P SP+A DLL ++L DKRL+A QAL HP+ +
Sbjct: 247 SGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQR 306
Query: 311 FRDPEEETEAQQPFDDSLEHE--KLTVDEWKQHIYKEIV 347
F P +E A++ HE +L+V E++ +Y+ I+
Sbjct: 307 FHCPSDEW-AREADVRPRAHEGVQLSVPEYRSRVYQMIL 344
>gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo
sapiens]
Length = 277
Score = 226 bits (577), Expect = 2e-59
Identities = 119/257 (46%), Positives = 165/257 (64%), Gaps = 17/257 (6%)
Query: 107 MPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKI 166
M M +L +++ ME E++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKI
Sbjct: 1 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
Query: 167 LDFGLARHADAE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFK 224
LDFGLAR A MT YVVTR+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF
Sbjct: 61 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFP 119
Query: 225 GKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------- 277
G+DY+DQ ++++ G P EF++KL ++Y+++ P+ F +LFP +
Sbjct: 120 GRDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSE 178
Query: 278 -----SPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHE 331
+ QA DLL KML +D KR++ AL HP+ + DP E E Q +D L+
Sbjct: 179 HNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDER 238
Query: 332 KLTVDEWKQHIYKEIVN 348
+ T++EWK+ IYKE++N
Sbjct: 239 EHTIEEWKELIYKEVMN 255
>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
sapiens]
Length = 677
Score = 220 bits (560), Expect = 2e-57
Identities = 117/260 (45%), Positives = 164/260 (63%), Gaps = 11/260 (4%)
Query: 110 MQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKIL 167
M++DL +I+ + E ++Y +YQ+L+GLKY+HSA V+HRDLKP NL VNE+CELKI
Sbjct: 1 MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIG 60
Query: 168 DFGLARH---ADAE----MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK 220
DFG+AR + AE MT YV TRWYRAPE++LS Y Q +D+WSVGCI EML +
Sbjct: 61 DFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARR 120
Query: 221 TLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQ 280
LF GK+Y+ QL I+ V G P +Q + + ++YIQSLP + ++P A Q
Sbjct: 121 QLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQ 180
Query: 281 AADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQ 340
A LL +ML + R++AA AL HPF + DP++E + PFD + + E LT + K+
Sbjct: 181 ALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKE 240
Query: 341 HIYKEIVNFSPIARKDSRRR 360
I EI +F AR++ R+
Sbjct: 241 AIVAEIEDFH--ARREGIRQ 258
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,740,109
Number of Sequences: 37866
Number of extensions: 586135
Number of successful extensions: 3646
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 739
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 1380
Number of HSP's gapped (non-prelim): 1037
length of query: 365
length of database: 18,247,518
effective HSP length: 104
effective length of query: 261
effective length of database: 14,309,454
effective search space: 3734767494
effective search space used: 3734767494
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.