BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo sapiens] (422 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 862 0.0 gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 853 0.0 gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 773 0.0 gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 731 0.0 gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 723 0.0 gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 723 0.0 gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 714 0.0 gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 682 0.0 gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 681 0.0 gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 669 0.0 gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 668 0.0 gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ... 572 e-163 gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 419 e-117 gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 328 6e-90 gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 321 7e-88 gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 318 8e-87 gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 311 7e-85 gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 310 1e-84 gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 275 7e-74 gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 267 2e-71 gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 264 1e-70 gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 264 1e-70 gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 263 3e-70 gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 256 4e-68 gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 243 2e-64 gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 243 2e-64 gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 243 2e-64 gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 213 2e-55 gi|149408126 nemo like kinase [Homo sapiens] 210 2e-54 gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 204 9e-53 >gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo sapiens] Length = 422 Score = 862 bits (2227), Expect = 0.0 Identities = 422/422 (100%), Positives = 422/422 (100%) Query: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV Sbjct: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60 Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY Sbjct: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN Sbjct: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN Sbjct: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 Query: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQV 420 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQV Sbjct: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQV 420 Query: 421 QQ 422 QQ Sbjct: 421 QQ 422 >gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo sapiens] Length = 464 Score = 853 bits (2204), Expect = 0.0 Identities = 417/417 (100%), Positives = 417/417 (100%) Query: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV Sbjct: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60 Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY Sbjct: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN Sbjct: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN Sbjct: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 Query: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 417 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS Sbjct: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 417 >gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo sapiens] Length = 426 Score = 773 bits (1995), Expect = 0.0 Identities = 379/379 (100%), Positives = 379/379 (100%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP Sbjct: 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 240 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 360 Query: 399 MNSEEKTKNGVVKGQPSPS 417 MNSEEKTKNGVVKGQPSPS Sbjct: 361 MNSEEKTKNGVVKGQPSPS 379 >gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1 [Homo sapiens] Length = 384 Score = 731 bits (1888), Expect = 0.0 Identities = 355/384 (92%), Positives = 371/384 (96%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 399 MNSEEKTKNGVVKGQPSPSAQVQQ 422 M+ EE+TKNGV++GQPSP AQVQQ Sbjct: 361 MDLEERTKNGVIRGQPSPLAQVQQ 384 >gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2 [Homo sapiens] Length = 427 Score = 723 bits (1867), Expect = 0.0 Identities = 350/378 (92%), Positives = 366/378 (96%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 399 MNSEEKTKNGVVKGQPSP 416 M+ EE+TKNGV++GQPSP Sbjct: 361 MDLEERTKNGVIRGQPSP 378 >gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1 [Homo sapiens] Length = 384 Score = 723 bits (1865), Expect = 0.0 Identities = 350/384 (91%), Positives = 369/384 (96%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++ +LFPG D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 399 MNSEEKTKNGVVKGQPSPSAQVQQ 422 M+ EE+TKNGV++GQPSP AQVQQ Sbjct: 361 MDLEERTKNGVIRGQPSPLAQVQQ 384 >gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2 [Homo sapiens] Length = 427 Score = 714 bits (1844), Expect = 0.0 Identities = 345/378 (91%), Positives = 364/378 (96%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++ +LFPG D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 399 MNSEEKTKNGVVKGQPSP 416 M+ EE+TKNGV++GQPSP Sbjct: 361 MDLEERTKNGVIRGQPSP 378 >gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1 [Homo sapiens] Length = 382 Score = 682 bits (1759), Expect = 0.0 Identities = 335/384 (87%), Positives = 356/384 (92%), Gaps = 2/384 (0%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 399 MNSEEKTKNGVVKGQPSPSAQVQQ 422 M+ EE++KNGVVK Q PSAQ+QQ Sbjct: 361 MDWEERSKNGVVKDQ--PSAQMQQ 382 >gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2 [Homo sapiens] Length = 424 Score = 681 bits (1756), Expect = 0.0 Identities = 332/380 (87%), Positives = 353/380 (92%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 399 MNSEEKTKNGVVKGQPSPSA 418 M+ EE++KNGVVK QPS +A Sbjct: 361 MDWEERSKNGVVKDQPSDAA 380 >gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1 [Homo sapiens] Length = 382 Score = 669 bits (1727), Expect = 0.0 Identities = 329/384 (85%), Positives = 354/384 (92%), Gaps = 2/384 (0%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 399 MNSEEKTKNGVVKGQPSPSAQVQQ 422 M+ EE++KNGVVK Q PSAQ+QQ Sbjct: 361 MDWEERSKNGVVKDQ--PSAQMQQ 382 >gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2 [Homo sapiens] Length = 424 Score = 668 bits (1724), Expect = 0.0 Identities = 326/380 (85%), Positives = 351/380 (92%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 399 MNSEEKTKNGVVKGQPSPSA 418 M+ EE++KNGVVK QPS +A Sbjct: 361 MDWEERSKNGVVKDQPSDAA 380 >gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo sapiens] Length = 277 Score = 572 bits (1473), Expect = e-163 Identities = 277/277 (100%), Positives = 277/277 (100%) Query: 146 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 205 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI Sbjct: 1 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60 Query: 206 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 265 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG Sbjct: 61 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120 Query: 266 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 325 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN Sbjct: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180 Query: 326 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 385 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH Sbjct: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240 Query: 386 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 422 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ Sbjct: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 277 >gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma [Homo sapiens] Length = 242 Score = 419 bits (1077), Expect = e-117 Identities = 207/231 (89%), Positives = 217/231 (93%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYI 269 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G D I Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231 >gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] Length = 364 Score = 328 bits (841), Expect = 6e-90 Identities = 171/356 (48%), Positives = 241/356 (67%), Gaps = 19/356 (5%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R Sbjct: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166 YREL L+K + H+N+I LL+VFTP ++E+F +VYLV LM A+L +++ + L E + Sbjct: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T Sbjct: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPE++L M Y + VDIWSVGCIM E+++ K LFPG DYIDQ +++E +GTP PE Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 Query: 286 FMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 + K+ R Y+++ P +F + N L A DLL +MLV+D Sbjct: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293 Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 +R+S +AL H Y + ++DP + P + YD+ ++ +E T+EEWKEL Y+EV++ Sbjct: 294 DQRVSAAEALAHAYFSQYHDPE--DEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347 >gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] Length = 365 Score = 321 bits (823), Expect = 7e-88 Identities = 169/355 (47%), Positives = 231/355 (65%), Gaps = 17/355 (4%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY +V + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ AKR Sbjct: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS 167 AYREL+L+K + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++ Sbjct: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR Sbjct: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTR 186 Query: 228 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G+DY+DQ ++++ G P EF Sbjct: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 ++KL ++Y+++ P+ F +LFP + + QA DLL KML +D Sbjct: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLELDVD 294 Query: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 KR++ AL HP+ + DP E E Q +D L+ + T++EWK+ IYKE++N Sbjct: 295 KRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348 >gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo sapiens] Length = 360 Score = 318 bits (814), Expect = 8e-87 Identities = 172/356 (48%), Positives = 233/356 (65%), Gaps = 19/356 (5%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166 YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + + Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 Query: 286 FMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 +KK+ + RNY+++ + + F +F + N L A DLL KMLV+D Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEKMLVLDS 293 Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 KRI+ AL H Y ++DP + P YD+ + R+ I+EWK L Y EV++ Sbjct: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVIS 347 >gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] Length = 367 Score = 311 bits (797), Expect = 7e-85 Identities = 168/372 (45%), Positives = 240/372 (64%), Gaps = 19/372 (5%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY EV + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ AKR Sbjct: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166 AYREL L+K + H+N+I LL+VFTP +TL++F D YLVM M +L ++++ E L +R+ Sbjct: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI 130 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YVVT Sbjct: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVT 188 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G D++DQ ++++ GTP E Sbjct: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248 Query: 286 FMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 F+++LQ +NY++ P+ F + ++ + A +LL KMLV+D Sbjct: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVLDA 296 Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 +R++ +AL HPY +D + P Q YD D+ + T++EWK + YKEV++ + Sbjct: 297 EQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354 Query: 405 TKNGVVKGQPSP 416 + G + +P Sbjct: 355 RQLGARVSKETP 366 >gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo sapiens] Length = 360 Score = 310 bits (795), Expect = 1e-84 Identities = 170/357 (47%), Positives = 232/357 (64%), Gaps = 21/357 (5%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166 YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + + Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+I+Q +++ GTP P Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP-PA 244 Query: 286 FMKKLQPT--VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343 ++ P+ RNY+++ + + F +F + N L A DLL KMLV+D Sbjct: 245 YLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEKMLVLD 292 Query: 344 PAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 KRI+ AL H Y ++DP + P YD+ + R+ I+EWK L Y EV++ Sbjct: 293 SDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVIS 347 >gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo sapiens] Length = 297 Score = 275 bits (702), Expect = 7e-74 Identities = 140/269 (52%), Positives = 189/269 (70%), Gaps = 5/269 (1%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166 YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + + Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 Query: 286 FMKKL-QPTVRNYVENRPKYAGLTFPKLF 313 +KK+ + RNY+++ + + F +F Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274 >gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo sapiens] Length = 307 Score = 267 bits (682), Expect = 2e-71 Identities = 135/245 (55%), Positives = 177/245 (72%), Gaps = 4/245 (1%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166 YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + + Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 Query: 286 FMKKL 290 +KK+ Sbjct: 246 LLKKI 250 >gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] Length = 360 Score = 264 bits (674), Expect = 1e-70 Identities = 148/353 (41%), Positives = 225/353 (63%), Gaps = 24/353 (6%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 V F V RY NL IG GA G+VC+AYD V VAIKK+S PF++QT+ +R RE+ Sbjct: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 171 ++ H+NII + ++ T+E+ +DVY+V +LM+ +L ++++ + L ++ + Y LY Sbjct: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTR 227 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191 Query: 228 YYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251 Query: 287 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 + + RNY+ + P + + +LFP++ S+A DLL KML +P Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNPH 299 Query: 346 KRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397 KRI V+ AL HPY+ +YDP+ E A P +D +LD+ E+ KELI++E Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350 >gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] Length = 360 Score = 264 bits (674), Expect = 1e-70 Identities = 148/353 (41%), Positives = 225/353 (63%), Gaps = 24/353 (6%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 V F V RY NL IG GA G+VC+AYD V VAIKK+S PF++QT+ +R RE+ Sbjct: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 171 ++ H+NII + ++ T+E+ +DVY+V +LM+ +L ++++ + L ++ + Y LY Sbjct: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTR 227 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191 Query: 228 YYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251 Query: 287 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 + + RNY+ + P + + +LFP++ S+A DLL KML +P Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNPH 299 Query: 346 KRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397 KRI V+ AL HPY+ +YDP+ E A P +D +LD+ E+ KELI++E Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350 >gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo sapiens] Length = 379 Score = 263 bits (671), Expect = 3e-70 Identities = 145/348 (41%), Positives = 221/348 (63%), Gaps = 24/348 (6%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ ++ Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 176 H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LYQ+L G Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 232 +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 Query: 233 EVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 290 E++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + + Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 RNY+++ P + + KLFP S S+A DLL +ML +P KRI+V Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPNKRITV 321 Query: 351 DDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397 ++AL HPY+ +YDP E A P + +LD+ E KELI++E Sbjct: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367 >gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo sapiens] Length = 357 Score = 256 bits (653), Expect = 4e-68 Identities = 135/323 (41%), Positives = 207/323 (64%), Gaps = 21/323 (6%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ ++ Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 176 H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LYQ+L G Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 232 +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 Query: 233 EVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 290 E++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + + Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 RNY+++ P + + KLFP S S+A DLL +ML +P KRI+V Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPNKRITV 321 Query: 351 DDALQHPYINVWYDPAEVEAPPP 373 ++AL HPY+ +YDP + P Sbjct: 322 EEALAHPYLEQYYDPTDEVGQSP 344 >gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 243 bits (620), Expect = 2e-64 Identities = 144/374 (38%), Positives = 221/374 (59%), Gaps = 28/374 (7%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL + Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQ 172 +K H NII++ ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225 Query: 228 YYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPE++L + Y + +D+WSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285 Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 ++ + VR Y+++ P + + ++P + QA LL +ML +P+ Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPGA------------DRQALSLLGRMLRFEPS 333 Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 RIS AL+HP++ ++DP E + PP +D D T E KE I E+ + + Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391 Query: 405 TKNGV---VKGQPS 415 + G+ ++ QPS Sbjct: 392 -REGIRQQIRFQPS 404 >gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 243 bits (620), Expect = 2e-64 Identities = 144/374 (38%), Positives = 221/374 (59%), Gaps = 28/374 (7%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL + Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQ 172 +K H NII++ ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225 Query: 228 YYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPE++L + Y + +D+WSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285 Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 ++ + VR Y+++ P + + ++P + QA LL +ML +P+ Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPGA------------DRQALSLLGRMLRFEPS 333 Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 RIS AL+HP++ ++DP E + PP +D D T E KE I E+ + + Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391 Query: 405 TKNGV---VKGQPS 415 + G+ ++ QPS Sbjct: 392 -REGIRQQIRFQPS 404 >gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 243 bits (620), Expect = 2e-64 Identities = 144/374 (38%), Positives = 221/374 (59%), Gaps = 28/374 (7%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL + Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQ 172 +K H NII++ ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225 Query: 228 YYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPE++L + Y + +D+WSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285 Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 ++ + VR Y+++ P + + ++P + QA LL +ML +P+ Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPGA------------DRQALSLLGRMLRFEPS 333 Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 RIS AL+HP++ ++DP E + PP +D D T E KE I E+ + + Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391 Query: 405 TKNGV---VKGQPS 415 + G+ ++ QPS Sbjct: 392 -REGIRQQIRFQPS 404 >gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo sapiens] Length = 335 Score = 213 bits (543), Expect = 2e-55 Identities = 130/347 (37%), Positives = 193/347 (55%), Gaps = 66/347 (19%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ ++ Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 176 H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LYQ+L G Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 232 +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 Query: 233 EVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 E++L GY +++DIWSVGCI+ EM+ Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEML---------------------------------- 239 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 NRP +FP ++L A DLL +ML +P KRI+V+ Sbjct: 240 -------SNRP--------------IFPGKHYLDQLNHILALDLLDRMLTFNPNKRITVE 278 Query: 352 DALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397 +AL HPY+ +YDP E A P + +LD+ E KELI++E Sbjct: 279 EALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 323 >gi|149408126 nemo like kinase [Homo sapiens] Length = 527 Score = 210 bits (534), Expect = 2e-54 Identities = 121/298 (40%), Positives = 181/298 (60%), Gaps = 16/298 (5%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 +PIG GA G+V + D + VA+KK+ FQN KR +REL ++ H N++S L Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201 Query: 128 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 185 ++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI Sbjct: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260 Query: 186 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 243 +HRD+KP N++V S+C LKI DFGLAR S MT VVT+YYRAPE+++G + N Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320 Query: 244 -VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 +DIWSVGCI E++ +ILF + I Q + + + LGTP E M+ + ++ P Sbjct: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 + + P L+ S + + H +A LL +MLV DP+KRIS DAL HPY++ Sbjct: 381 -HKQPSLPVLYTLS---SQATH------EAVHLLCRMLVFDPSKRISAKDALAHPYLD 428 >gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] Length = 544 Score = 204 bits (520), Expect = 9e-53 Identities = 131/375 (34%), Positives = 208/375 (55%), Gaps = 39/375 (10%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 118 +++RY + +G GA GIV A D VAIKK+ F+++T A+R +RE+ L++ Sbjct: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 176 +H NIISLL+V E +D+YLV E MD +L VI+ L + + YQ+L Sbjct: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 230 + LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ G +T YV TR+YR Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184 Query: 231 APEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 APEV+L Y VD+WS+GCI+GEM+R + LFPG + Q ++E + P E + Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244 Query: 290 L----QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 L + +V + + +RP+ D+L P D+ + +A DLL ++LV P Sbjct: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290 Query: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM------ 399 KR+S ALQHPY+ ++ P++ A + + + + ++ E++ +Y+ ++ Sbjct: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSS 350 Query: 400 -NSEEKTKNGVVKGQ 413 S EK GV Q Sbjct: 351 GTSREKGPEGVSPSQ 365 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.136 0.408 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,418,249 Number of Sequences: 37866 Number of extensions: 715993 Number of successful extensions: 3810 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 755 Number of HSP's successfully gapped in prelim test: 47 Number of HSP's that attempted gapping in prelim test: 1625 Number of HSP's gapped (non-prelim): 1112 length of query: 422 length of database: 18,247,518 effective HSP length: 105 effective length of query: 317 effective length of database: 14,271,588 effective search space: 4524093396 effective search space used: 4524093396 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.