Search of human proteins with 4506081

Search of human proteins with 4506081

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
         (422 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s...   862   0.0  
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ...   853   0.0  
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ...   773   0.0  
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha...   731   0.0  
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph...   723   0.0  
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta...   723   0.0  
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta...   714   0.0  
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta...   682   0.0  
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta...   681   0.0  
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph...   669   0.0  
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph...   668   0.0  
gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ...   572   e-163
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam...   419   e-117
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]        328   6e-90
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]         321   7e-88
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ...   318   8e-87
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]        311   7e-85
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s...   310   1e-84
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ...   275   7e-74
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ...   267   2e-71
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]         264   1e-70
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]         264   1e-70
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s...   263   3e-70
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s...   256   4e-68
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s...   243   2e-64
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ...   243   2e-64
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ...   243   2e-64
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ...   213   2e-55
gi|149408126 nemo like kinase [Homo sapiens]                          210   2e-54
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]        204   9e-53

>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
           sapiens]
          Length = 422

 Score =  862 bits (2227), Expect = 0.0
 Identities = 422/422 (100%), Positives = 422/422 (100%)

Query: 1   MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60
           MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
Sbjct: 1   MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60

Query: 61  LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120
           LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
Sbjct: 61  LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120

Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180
           KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180

Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240
           HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
Sbjct: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240

Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300
           KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
Sbjct: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300

Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360
           RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
Sbjct: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360

Query: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQV 420
           VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQV
Sbjct: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQV 420

Query: 421 QQ 422
           QQ
Sbjct: 421 QQ 422


>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
           sapiens]
          Length = 464

 Score =  853 bits (2204), Expect = 0.0
 Identities = 417/417 (100%), Positives = 417/417 (100%)

Query: 1   MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60
           MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
Sbjct: 1   MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60

Query: 61  LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120
           LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
Sbjct: 61  LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120

Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180
           KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180

Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240
           HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
Sbjct: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240

Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300
           KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
Sbjct: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300

Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360
           RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
Sbjct: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360

Query: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 417
           VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS
Sbjct: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 417


>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
           sapiens]
          Length = 426

 Score =  773 bits (1995), Expect = 0.0
 Identities = 379/379 (100%), Positives = 379/379 (100%)

Query: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
           MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP
Sbjct: 1   MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60

Query: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
           FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 120

Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 240

Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
           LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300

Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
           MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 360

Query: 399 MNSEEKTKNGVVKGQPSPS 417
           MNSEEKTKNGVVKGQPSPS
Sbjct: 361 MNSEEKTKNGVVKGQPSPS 379


>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
           [Homo sapiens]
          Length = 384

 Score =  731 bits (1888), Expect = 0.0
 Identities = 355/384 (92%), Positives = 371/384 (96%)

Query: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
           MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
           FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
           MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240

Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
           LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
           MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 399 MNSEEKTKNGVVKGQPSPSAQVQQ 422
           M+ EE+TKNGV++GQPSP AQVQQ
Sbjct: 361 MDLEERTKNGVIRGQPSPLAQVQQ 384


>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
           [Homo sapiens]
          Length = 427

 Score =  723 bits (1867), Expect = 0.0
 Identities = 350/378 (92%), Positives = 366/378 (96%)

Query: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
           MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
           FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
           MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240

Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
           LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
           MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 399 MNSEEKTKNGVVKGQPSP 416
           M+ EE+TKNGV++GQPSP
Sbjct: 361 MDLEERTKNGVIRGQPSP 378


>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
           [Homo sapiens]
          Length = 384

 Score =  723 bits (1865), Expect = 0.0
 Identities = 350/384 (91%), Positives = 369/384 (96%)

Query: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
           MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
           FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++  +LFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240

Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
           LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
           MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 399 MNSEEKTKNGVVKGQPSPSAQVQQ 422
           M+ EE+TKNGV++GQPSP AQVQQ
Sbjct: 361 MDLEERTKNGVIRGQPSPLAQVQQ 384


>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
           [Homo sapiens]
          Length = 427

 Score =  714 bits (1844), Expect = 0.0
 Identities = 345/378 (91%), Positives = 364/378 (96%)

Query: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
           MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
           FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++  +LFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240

Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
           LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
           MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 399 MNSEEKTKNGVVKGQPSP 416
           M+ EE+TKNGV++GQPSP
Sbjct: 361 MDLEERTKNGVIRGQPSP 378


>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
           [Homo sapiens]
          Length = 382

 Score =  682 bits (1759), Expect = 0.0
 Identities = 335/384 (87%), Positives = 356/384 (92%), Gaps = 2/384 (0%)

Query: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
           MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL  NVA+KKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
           FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240

Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
           LGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
           MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 399 MNSEEKTKNGVVKGQPSPSAQVQQ 422
           M+ EE++KNGVVK Q  PSAQ+QQ
Sbjct: 361 MDWEERSKNGVVKDQ--PSAQMQQ 382


>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
           [Homo sapiens]
          Length = 424

 Score =  681 bits (1756), Expect = 0.0
 Identities = 332/380 (87%), Positives = 353/380 (92%)

Query: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
           MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL  NVA+KKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
           FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240

Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
           LGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
           MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 399 MNSEEKTKNGVVKGQPSPSA 418
           M+ EE++KNGVVK QPS +A
Sbjct: 361 MDWEERSKNGVVKDQPSDAA 380


>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
           [Homo sapiens]
          Length = 382

 Score =  669 bits (1727), Expect = 0.0
 Identities = 329/384 (85%), Positives = 354/384 (92%), Gaps = 2/384 (0%)

Query: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
           MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL  NVA+KKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
           FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+  ++F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240

Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
           LGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
           MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 399 MNSEEKTKNGVVKGQPSPSAQVQQ 422
           M+ EE++KNGVVK Q  PSAQ+QQ
Sbjct: 361 MDWEERSKNGVVKDQ--PSAQMQQ 382


>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
           [Homo sapiens]
          Length = 424

 Score =  668 bits (1724), Expect = 0.0
 Identities = 326/380 (85%), Positives = 351/380 (92%)

Query: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
           MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL  NVA+KKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
           FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+  ++F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240

Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
           LGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
           MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 399 MNSEEKTKNGVVKGQPSPSA 418
           M+ EE++KNGVVK QPS +A
Sbjct: 361 MDWEERSKNGVVKDQPSDAA 380


>gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo
           sapiens]
          Length = 277

 Score =  572 bits (1473), Expect = e-163
 Identities = 277/277 (100%), Positives = 277/277 (100%)

Query: 146 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 205
           MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60

Query: 206 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 265
           LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG
Sbjct: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120

Query: 266 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 325
           RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN
Sbjct: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180

Query: 326 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 385
           KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH
Sbjct: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240

Query: 386 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 422
           TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ
Sbjct: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 277


>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
           [Homo sapiens]
          Length = 242

 Score =  419 bits (1077), Expect = e-117
 Identities = 207/231 (89%), Positives = 217/231 (93%)

Query: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
           MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL  NVA+KKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
           FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYI 269
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+  ++F G D I
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231


>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
          Length = 364

 Score =  328 bits (841), Expect = 6e-90
 Identities = 171/356 (48%), Positives = 241/356 (67%), Gaps = 19/356 (5%)

Query: 48  FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
           FY  E+  + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+  HA+R
Sbjct: 8   FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67

Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166
            YREL L+K + H+N+I LL+VFTP  ++E+F +VYLV  LM A+L  +++ + L  E +
Sbjct: 68  TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127

Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
            +L+YQ+L G+K++HSAGIIHRDLKPSN+ V  DC L+ILDFGLAR A     MT YV T
Sbjct: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185

Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
           R+YRAPE++L  M Y + VDIWSVGCIM E+++ K LFPG DYIDQ  +++E +GTP PE
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245

Query: 286 FMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
            + K+     R Y+++ P         +F  +        N L    A DLL +MLV+D 
Sbjct: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293

Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
            +R+S  +AL H Y + ++DP   + P  + YD+ ++ +E T+EEWKEL Y+EV++
Sbjct: 294 DQRVSAAEALAHAYFSQYHDPE--DEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347


>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
          Length = 365

 Score =  321 bits (823), Expect = 7e-88
 Identities = 169/355 (47%), Positives = 231/355 (65%), Gaps = 17/355 (4%)

Query: 48  FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
           FY  +V  + + + K Y +   +GSGA G VC+A D      VAIKKLSRPFQ++  AKR
Sbjct: 9   FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68

Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS 167
           AYREL+L+K + H+N+I LL+VFTP  +L  F D YLVM  M  +L +++ ME   E++ 
Sbjct: 69  AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128

Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227
           YL+YQML G+K++HSAG++HRDLKP N+ V  DC LKILDFGLAR A     MT YVVTR
Sbjct: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTR 186

Query: 228 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
           +YRAPEVIL  M Y + VDIWSVGCIM EM+  K LF G+DY+DQ  ++++  G P  EF
Sbjct: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246

Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
           ++KL     ++Y+++ P+     F +LFP +            + QA DLL KML +D  
Sbjct: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLELDVD 294

Query: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
           KR++   AL HP+   + DP E E    Q +D  L+  + T++EWK+ IYKE++N
Sbjct: 295 KRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348


>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
           sapiens]
          Length = 360

 Score =  318 bits (814), Expect = 8e-87
 Identities = 172/356 (48%), Positives = 233/356 (65%), Gaps = 19/356 (5%)

Query: 48  FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
           FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+  HAKR
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166
            YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  +++  +L  + +
Sbjct: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127

Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185

Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
           R+YRAPE++L  M Y + VDIWSVGCIM E++  + LFPG D+IDQ   ++  +GTP  E
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245

Query: 286 FMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
            +KK+   + RNY+++  +   + F  +F  +        N L    A DLL KMLV+D 
Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEKMLVLDS 293

Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
            KRI+   AL H Y   ++DP +     P  YD+  + R+  I+EWK L Y EV++
Sbjct: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVIS 347


>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
          Length = 367

 Score =  311 bits (797), Expect = 7e-85
 Identities = 168/372 (45%), Positives = 240/372 (64%), Gaps = 19/372 (5%)

Query: 48  FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
           FY  EV  + + V   Y++L+P+GSGA G VC+A D      VAIKKL RPFQ++  AKR
Sbjct: 11  FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70

Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166
           AYREL L+K + H+N+I LL+VFTP +TL++F D YLVM  M  +L ++++ E L  +R+
Sbjct: 71  AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI 130

Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
            +L+YQML G++++H+AGIIHRDLKP N+ V  DC LKILDFGLAR A +   MT YVVT
Sbjct: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVT 188

Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
           R+YRAPEVIL  M Y + VDIWSVGCIM EM+  K LF G D++DQ  ++++  GTP  E
Sbjct: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248

Query: 286 FMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
           F+++LQ    +NY++  P+     F  +  ++            +  A +LL KMLV+D 
Sbjct: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVLDA 296

Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404
            +R++  +AL HPY    +D    + P  Q YD   D+ + T++EWK + YKEV++ +  
Sbjct: 297 EQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354

Query: 405 TKNGVVKGQPSP 416
            + G    + +P
Sbjct: 355 RQLGARVSKETP 366


>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
           sapiens]
          Length = 360

 Score =  310 bits (795), Expect = 1e-84
 Identities = 170/357 (47%), Positives = 232/357 (64%), Gaps = 21/357 (5%)

Query: 48  FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
           FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+  HAKR
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166
            YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  +++  +L  + +
Sbjct: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127

Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185

Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
           R+YRAPE++L  M Y + VDIWSVGCIM E++  + LFPG D+I+Q  +++   GTP P 
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP-PA 244

Query: 286 FMKKLQPT--VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343
           ++    P+   RNY+++  +   + F  +F  +        N L    A DLL KMLV+D
Sbjct: 245 YLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEKMLVLD 292

Query: 344 PAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
             KRI+   AL H Y   ++DP +     P  YD+  + R+  I+EWK L Y EV++
Sbjct: 293 SDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVIS 347


>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
           sapiens]
          Length = 297

 Score =  275 bits (702), Expect = 7e-74
 Identities = 140/269 (52%), Positives = 189/269 (70%), Gaps = 5/269 (1%)

Query: 48  FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
           FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+  HAKR
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166
            YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  +++  +L  + +
Sbjct: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127

Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185

Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
           R+YRAPE++L  M Y + VDIWSVGCIM E++  + LFPG D+IDQ   ++  +GTP  E
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245

Query: 286 FMKKL-QPTVRNYVENRPKYAGLTFPKLF 313
            +KK+   + RNY+++  +   + F  +F
Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274


>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
           sapiens]
          Length = 307

 Score =  267 bits (682), Expect = 2e-71
 Identities = 135/245 (55%), Positives = 177/245 (72%), Gaps = 4/245 (1%)

Query: 48  FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
           FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+  HAKR
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166
            YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  +++  +L  + +
Sbjct: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127

Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185

Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
           R+YRAPE++L  M Y + VDIWSVGCIM E++  + LFPG D+IDQ   ++  +GTP  E
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245

Query: 286 FMKKL 290
            +KK+
Sbjct: 246 LLKKI 250


>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  264 bits (674), Expect = 1e-70
 Identities = 148/353 (41%), Positives = 225/353 (63%), Gaps = 24/353 (6%)

Query: 53  VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112
           V    F V  RY NL  IG GA G+VC+AYD V    VAIKK+S PF++QT+ +R  RE+
Sbjct: 14  VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72

Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 171
            ++    H+NII + ++     T+E+ +DVY+V +LM+ +L ++++ + L ++ + Y LY
Sbjct: 73  KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131

Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTR 227
           Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191

Query: 228 YYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
           +YRAPE++L   GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++  LG+P  E 
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251

Query: 287 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
           +   +    RNY+ + P    + + +LFP++             S+A DLL KML  +P 
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNPH 299

Query: 346 KRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
           KRI V+ AL HPY+  +YDP+ E  A  P  +D +LD+     E+ KELI++E
Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350


>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  264 bits (674), Expect = 1e-70
 Identities = 148/353 (41%), Positives = 225/353 (63%), Gaps = 24/353 (6%)

Query: 53  VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112
           V    F V  RY NL  IG GA G+VC+AYD V    VAIKK+S PF++QT+ +R  RE+
Sbjct: 14  VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72

Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 171
            ++    H+NII + ++     T+E+ +DVY+V +LM+ +L ++++ + L ++ + Y LY
Sbjct: 73  KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131

Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTR 227
           Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191

Query: 228 YYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
           +YRAPE++L   GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++  LG+P  E 
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251

Query: 287 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
           +   +    RNY+ + P    + + +LFP++             S+A DLL KML  +P 
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNPH 299

Query: 346 KRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
           KRI V+ AL HPY+  +YDP+ E  A  P  +D +LD+     E+ KELI++E
Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350


>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
           sapiens]
          Length = 379

 Score =  263 bits (671), Expect = 3e-70
 Identities = 145/348 (41%), Positives = 221/348 (63%), Gaps = 24/348 (6%)

Query: 58  FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117
           F V  RY  L+ IG GA G+V +AYD V    VAIKK+S PF++QT+ +R  RE+ ++  
Sbjct: 36  FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94

Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 176
             H+N+I + ++     TLE  +DVY+V +LM+ +L ++++  +L ++ + Y LYQ+L G
Sbjct: 95  FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153

Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 232
           +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213

Query: 233 EVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 290
           E++L   GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++  LG+P  E +   +
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273

Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350
               RNY+++ P    + + KLFP S             S+A DLL +ML  +P KRI+V
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPNKRITV 321

Query: 351 DDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
           ++AL HPY+  +YDP  E  A  P  +  +LD+     E  KELI++E
Sbjct: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367


>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
           sapiens]
          Length = 357

 Score =  256 bits (653), Expect = 4e-68
 Identities = 135/323 (41%), Positives = 207/323 (64%), Gaps = 21/323 (6%)

Query: 58  FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117
           F V  RY  L+ IG GA G+V +AYD V    VAIKK+S PF++QT+ +R  RE+ ++  
Sbjct: 36  FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94

Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 176
             H+N+I + ++     TLE  +DVY+V +LM+ +L ++++  +L ++ + Y LYQ+L G
Sbjct: 95  FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153

Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 232
           +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213

Query: 233 EVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 290
           E++L   GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++  LG+P  E +   +
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273

Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350
               RNY+++ P    + + KLFP S             S+A DLL +ML  +P KRI+V
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPNKRITV 321

Query: 351 DDALQHPYINVWYDPAEVEAPPP 373
           ++AL HPY+  +YDP +     P
Sbjct: 322 EEALAHPYLEQYYDPTDEVGQSP 344


>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  243 bits (620), Expect = 2e-64
 Identities = 144/374 (38%), Positives = 221/374 (59%), Gaps = 28/374 (7%)

Query: 55  DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114
           D TF V   Y+ ++ IG+GA G+V +A   +  + VAIKK+   F   T+AKR  REL +
Sbjct: 46  DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105

Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQ 172
           +K   H NII++ ++  P     EF+ VY+V++LM+++L Q+I     L  E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165

Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227
           +L G+K++HSA +IHRDLKPSN++V  +C LKI DFG+AR   TS     + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225

Query: 228 YYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
           +YRAPE++L +  Y + +D+WSVGCI GEM+  + LFPG++Y+ Q   ++  LGTP P  
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285

Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
           ++ +    VR Y+++ P    + +  ++P +              QA  LL +ML  +P+
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPGA------------DRQALSLLGRMLRFEPS 333

Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404
            RIS   AL+HP++  ++DP  E +  PP  +D   D    T E  KE I  E+ +   +
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391

Query: 405 TKNGV---VKGQPS 415
            + G+   ++ QPS
Sbjct: 392 -REGIRQQIRFQPS 404


>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  243 bits (620), Expect = 2e-64
 Identities = 144/374 (38%), Positives = 221/374 (59%), Gaps = 28/374 (7%)

Query: 55  DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114
           D TF V   Y+ ++ IG+GA G+V +A   +  + VAIKK+   F   T+AKR  REL +
Sbjct: 46  DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105

Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQ 172
           +K   H NII++ ++  P     EF+ VY+V++LM+++L Q+I     L  E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165

Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227
           +L G+K++HSA +IHRDLKPSN++V  +C LKI DFG+AR   TS     + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225

Query: 228 YYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
           +YRAPE++L +  Y + +D+WSVGCI GEM+  + LFPG++Y+ Q   ++  LGTP P  
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285

Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
           ++ +    VR Y+++ P    + +  ++P +              QA  LL +ML  +P+
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPGA------------DRQALSLLGRMLRFEPS 333

Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404
            RIS   AL+HP++  ++DP  E +  PP  +D   D    T E  KE I  E+ +   +
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391

Query: 405 TKNGV---VKGQPS 415
            + G+   ++ QPS
Sbjct: 392 -REGIRQQIRFQPS 404


>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  243 bits (620), Expect = 2e-64
 Identities = 144/374 (38%), Positives = 221/374 (59%), Gaps = 28/374 (7%)

Query: 55  DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114
           D TF V   Y+ ++ IG+GA G+V +A   +  + VAIKK+   F   T+AKR  REL +
Sbjct: 46  DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105

Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQ 172
           +K   H NII++ ++  P     EF+ VY+V++LM+++L Q+I     L  E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165

Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227
           +L G+K++HSA +IHRDLKPSN++V  +C LKI DFG+AR   TS     + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225

Query: 228 YYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
           +YRAPE++L +  Y + +D+WSVGCI GEM+  + LFPG++Y+ Q   ++  LGTP P  
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285

Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
           ++ +    VR Y+++ P    + +  ++P +              QA  LL +ML  +P+
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPGA------------DRQALSLLGRMLRFEPS 333

Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404
            RIS   AL+HP++  ++DP  E +  PP  +D   D    T E  KE I  E+ +   +
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391

Query: 405 TKNGV---VKGQPS 415
            + G+   ++ QPS
Sbjct: 392 -REGIRQQIRFQPS 404


>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
           sapiens]
          Length = 335

 Score =  213 bits (543), Expect = 2e-55
 Identities = 130/347 (37%), Positives = 193/347 (55%), Gaps = 66/347 (19%)

Query: 58  FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117
           F V  RY  L+ IG GA G+V +AYD V    VAIKK+S PF++QT+ +R  RE+ ++  
Sbjct: 36  FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94

Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 176
             H+N+I + ++     TLE  +DVY+V +LM+ +L ++++  +L ++ + Y LYQ+L G
Sbjct: 95  FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153

Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 232
           +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213

Query: 233 EVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291
           E++L   GY +++DIWSVGCI+ EM+                                  
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEML---------------------------------- 239

Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351
                   NRP              +FP     ++L    A DLL +ML  +P KRI+V+
Sbjct: 240 -------SNRP--------------IFPGKHYLDQLNHILALDLLDRMLTFNPNKRITVE 278

Query: 352 DALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
           +AL HPY+  +YDP  E  A  P  +  +LD+     E  KELI++E
Sbjct: 279 EALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 323


>gi|149408126 nemo like kinase [Homo sapiens]
          Length = 527

 Score =  210 bits (534), Expect = 2e-54
 Identities = 121/298 (40%), Positives = 181/298 (60%), Gaps = 16/298 (5%)

Query: 68  KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127
           +PIG GA G+V +  D    + VA+KK+   FQN    KR +REL ++    H N++S L
Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201

Query: 128 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 185
           ++  P   ++ F+++Y+V ELM ++L ++I     L  + +   LYQ+L G+K+LHSAGI
Sbjct: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260

Query: 186 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 243
           +HRD+KP N++V S+C LKI DFGLAR      S  MT  VVT+YYRAPE+++G  +  N
Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320

Query: 244 -VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302
            +DIWSVGCI  E++  +ILF  +  I Q + + + LGTP  E M+      + ++   P
Sbjct: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380

Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360
            +   + P L+  S   + + H      +A  LL +MLV DP+KRIS  DAL HPY++
Sbjct: 381 -HKQPSLPVLYTLS---SQATH------EAVHLLCRMLVFDPSKRISAKDALAHPYLD 428


>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
          Length = 544

 Score =  204 bits (520), Expect = 9e-53
 Identities = 131/375 (34%), Positives = 208/375 (55%), Gaps = 39/375 (10%)

Query: 60  VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 118
           +++RY   + +G GA GIV  A D      VAIKK+   F+++T A+R +RE+ L++   
Sbjct: 9   IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68

Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 176
           +H NIISLL+V       E  +D+YLV E MD +L  VI+    L    +  + YQ+L  
Sbjct: 69  DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124

Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 230
            + LHS  ++HRD KPSN+++ ++CT+K+ DFGLAR+ G          +T YV TR+YR
Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184

Query: 231 APEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289
           APEV+L    Y   VD+WS+GCI+GEM+R + LFPG   + Q   ++E +  P  E +  
Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244

Query: 290 L----QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
           L    + +V + + +RP+           D+L P D+      + +A DLL ++LV  P 
Sbjct: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290

Query: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM------ 399
           KR+S   ALQHPY+  ++ P++  A    +  +  +  + ++ E++  +Y+ ++      
Sbjct: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSS 350

Query: 400 -NSEEKTKNGVVKGQ 413
             S EK   GV   Q
Sbjct: 351 GTSREKGPEGVSPSQ 365


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,418,249
Number of Sequences: 37866
Number of extensions: 715993
Number of successful extensions: 3810
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 755
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 1625
Number of HSP's gapped (non-prelim): 1112
length of query: 422
length of database: 18,247,518
effective HSP length: 105
effective length of query: 317
effective length of database: 14,271,588
effective search space: 4524093396
effective search space used: 4524093396
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.