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Search of human proteins with 4506057
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
(351 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 716 0.0
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 688 0.0
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 667 0.0
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 644 0.0
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 580 e-166
gi|46909587 cAMP-dependent protein kinase catalytic subunit beta... 519 e-147
gi|4826948 protein kinase, X-linked [Homo sapiens] 374 e-104
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 280 2e-75
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 280 2e-75
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 271 6e-73
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 269 3e-72
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 269 3e-72
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 269 3e-72
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 269 3e-72
gi|4502023 AKT2 kinase [Homo sapiens] 268 5e-72
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 268 7e-72
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 264 8e-71
gi|62241015 AKT1 kinase [Homo sapiens] 264 1e-70
gi|62241013 AKT1 kinase [Homo sapiens] 264 1e-70
gi|62241011 AKT1 kinase [Homo sapiens] 264 1e-70
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 264 1e-70
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 264 1e-70
gi|5453974 protein kinase N2 [Homo sapiens] 254 8e-68
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 250 1e-66
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 245 4e-65
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 245 4e-65
gi|28557781 protein kinase C, eta [Homo sapiens] 245 5e-65
gi|4506067 protein kinase C, alpha [Homo sapiens] 244 8e-65
gi|4885563 protein kinase C, epsilon [Homo sapiens] 241 7e-64
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 239 3e-63
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 716 bits (1847), Expect = 0.0
Identities = 351/351 (100%), Positives = 351/351 (100%)
Query: 1 MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML
Sbjct: 1 MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
Query: 61 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
Sbjct: 61 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
Sbjct: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
Query: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
Sbjct: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
Query: 241 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT 300
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT
Sbjct: 241 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT 300
Query: 301 TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 351
TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
Sbjct: 301 TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 351
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 688 bits (1776), Expect = 0.0
Identities = 336/337 (99%), Positives = 337/337 (100%)
Query: 15 SVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI 74
S+KEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI
Sbjct: 62 SMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI 121
Query: 75 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR 134
LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR
Sbjct: 122 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR 181
Query: 135 RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG 194
RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG
Sbjct: 182 RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG 241
Query: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG
Sbjct: 242 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 301
Query: 255 KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAP 314
KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAP
Sbjct: 302 KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAP 361
Query: 315 FIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 351
FIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
Sbjct: 362 FIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 398
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 667 bits (1720), Expect = 0.0
Identities = 326/351 (92%), Positives = 335/351 (95%)
Query: 1 MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
MGNAA AKKGSE ESVKEFLAKAKEDFLKKWE+P QN A L+ FER KTLGTGSFGRVML
Sbjct: 1 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML 60
Query: 61 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
VKHK T +YAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV+LE++FKDNSNLYMV
Sbjct: 61 VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV 120
Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID QGY
Sbjct: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180
Query: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
Sbjct: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
Query: 241 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT 300
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGV+DIK HKWFAT
Sbjct: 241 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300
Query: 301 TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 351
TDWIAIYQRKVEAPFIPKF+G GDTSNFDDYEEE+IRVSI EKC KEF EF
Sbjct: 301 TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 644 bits (1661), Expect = 0.0
Identities = 314/341 (92%), Positives = 323/341 (94%)
Query: 11 SEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYY 70
S VKEFLAKAKEDFLKKWE+P QN A L+ FER KTLGTGSFGRVMLVKHK T +Y
Sbjct: 3 SNSSDVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY 62
Query: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 130
AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV+LE++FKDNSNLYMVMEYVPGGEMF
Sbjct: 63 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF 122
Query: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK 190
SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID QGYIQVTDFGFAK
Sbjct: 123 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 182
Query: 191 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250
RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK
Sbjct: 183 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 242
Query: 251 IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRK 310
IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGV+DIK HKWFATTDWIAIYQRK
Sbjct: 243 IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRK 302
Query: 311 VEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 351
VEAPFIPKF+G GDTSNFDDYEEE+IRVSI EKC KEF EF
Sbjct: 303 VEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 580 bits (1496), Expect = e-166
Identities = 276/351 (78%), Positives = 311/351 (88%)
Query: 1 MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
MGNA K + ESV EFLAKA+ DFL +W NP QN A + FER +TLG GSFGRVML
Sbjct: 1 MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML 60
Query: 61 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
V+H+ T +YAMKIL+KQKVVK+KQ+EH LNEKRILQA++FPFLV+L+++FKDNS LY+V
Sbjct: 61 VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV 120
Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
MEYVPGGEMFS L+R+GRFSEPHA FYAAQ+VL +YLHSLDLI+RDLKPENLLID QGY
Sbjct: 121 MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY 180
Query: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
+QVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMA G+PPF+
Sbjct: 181 LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY 240
Query: 241 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT 300
ADQPIQIYEKIVSG+VRFPS SSDLK LLR+LLQVDLTKRFGNL+NGV DIK HKWFAT
Sbjct: 241 ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT 300
Query: 301 TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 351
T WIAIY++KVEAPFIPK+ G GD SNFDDYEEE++R+SI EKCAKEF EF
Sbjct: 301 TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF 351
>gi|46909587 cAMP-dependent protein kinase catalytic subunit beta
isoform 3 [Homo sapiens]
Length = 257
Score = 519 bits (1337), Expect = e-147
Identities = 255/255 (100%), Positives = 255/255 (100%)
Query: 1 MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML
Sbjct: 1 MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
Query: 61 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
Sbjct: 61 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
Sbjct: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
Query: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
Sbjct: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
Query: 241 ADQPIQIYEKIVSGK 255
ADQPIQIYEKIVSGK
Sbjct: 241 ADQPIQIYEKIVSGK 255
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 374 bits (959), Expect = e-104
Identities = 165/295 (55%), Positives = 225/295 (76%)
Query: 41 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
L+DF+ T+GTG+FGRV LVK K + ++A+K++ V++LKQ +H NEK +L+ V+
Sbjct: 46 LQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS 105
Query: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160
PFL+RL + + D LYM+MEYVPGGE+FS+LR GRFS FY+A+I+ EYLHS
Sbjct: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165
Query: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 220
+++YRDLKPEN+L+D G+I++TDFGFAK++ RTWTLCGTPEYLAPE+I SKG+ +AV
Sbjct: 166 KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAV 225
Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTK 280
DWWALG+LI+EM +G+PPFF D P IY+KI++GK+ FP H +KDL++ LL VD T+
Sbjct: 226 DWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTR 285
Query: 281 RFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEED 335
R GN+KNG +D+K H+WF + DW A+ QRK++ P +PK G GDTSNF+ Y E D
Sbjct: 286 RLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPEND 340
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 280 bits (715), Expect = 2e-75
Identities = 140/303 (46%), Positives = 199/303 (65%), Gaps = 5/303 (1%)
Query: 38 NAGLEDFERKKTLGTGSFGRVMLVKHKATE-QYYAMKILDKQKVVKLKQIEHTLNEKRIL 96
N L DF TLG G FGRV LV+ K+ E + +AMKIL K+ +V +Q EH +EK+I+
Sbjct: 354 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 413
Query: 97 QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156
Q + F+VRL FKD+ LYM+ME GGE+++ LR G F + RFY A +V F
Sbjct: 414 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 473
Query: 157 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSK 214
YLHS +IYRDLKPENL++DH+GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+K
Sbjct: 474 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 533
Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRN 272
G++ + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP + + +L++
Sbjct: 534 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 593
Query: 273 LLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYE 332
L + + ++R GNLKNGV DI+ HKWF +W + + + P IP DTSNFD +
Sbjct: 594 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFP 653
Query: 333 EED 335
E++
Sbjct: 654 EDN 656
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 280 bits (715), Expect = 2e-75
Identities = 140/303 (46%), Positives = 199/303 (65%), Gaps = 5/303 (1%)
Query: 38 NAGLEDFERKKTLGTGSFGRVMLVKHKATE-QYYAMKILDKQKVVKLKQIEHTLNEKRIL 96
N L DF TLG G FGRV LV+ K+ E + +AMKIL K+ +V +Q EH +EK+I+
Sbjct: 369 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 428
Query: 97 QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156
Q + F+VRL FKD+ LYM+ME GGE+++ LR G F + RFY A +V F
Sbjct: 429 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 488
Query: 157 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSK 214
YLHS +IYRDLKPENL++DH+GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+K
Sbjct: 489 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 548
Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRN 272
G++ + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP + + +L++
Sbjct: 549 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 608
Query: 273 LLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYE 332
L + + ++R GNLKNGV DI+ HKWF +W + + + P IP DTSNFD +
Sbjct: 609 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFP 668
Query: 333 EED 335
E++
Sbjct: 669 EDN 671
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 271 bits (693), Expect = 6e-73
Identities = 135/302 (44%), Positives = 197/302 (65%), Gaps = 4/302 (1%)
Query: 37 NNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRIL 96
+++ ++ E TLG G FGRV LVK K +AMK + K+ +V KQ EH +EKRIL
Sbjct: 446 SSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRIL 505
Query: 97 QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156
+ + PF+V+L FKDN +YM++E GGE++S LR G F EP ++F A + F+
Sbjct: 506 EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFD 565
Query: 157 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSK 214
YLH L +IYRDLKPENL++D +GY+++ DFGFAK++ +TWT CGTPEY+APE+IL+K
Sbjct: 566 YLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNK 625
Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRN 272
G++ +VD+W+LG+L+YE+ G PPF + Y I+ G K+ FP + +DL+R
Sbjct: 626 GHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRR 685
Query: 273 LLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYE 332
L + + T+R GNLKNG++DIK H+W +W + R + +P + +G D S FD Y
Sbjct: 686 LCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYP 745
Query: 333 EE 334
E
Sbjct: 746 PE 747
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 269 bits (687), Expect = 3e-72
Identities = 134/313 (42%), Positives = 202/313 (64%), Gaps = 7/313 (2%)
Query: 34 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
P+ N +A DF K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 87 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 146
Query: 93 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
+ +L + V PFLV L ++F+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 147 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 206
Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 207 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 266
Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 268
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 267 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 326
Query: 269 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 328
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P G D +F
Sbjct: 327 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 385
Query: 329 D-DYEEEDIRVSI 340
D ++ EE + SI
Sbjct: 386 DPEFTEEPVPNSI 398
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 269 bits (687), Expect = 3e-72
Identities = 134/313 (42%), Positives = 202/313 (64%), Gaps = 7/313 (2%)
Query: 34 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
P+ N +A DF K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 101 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 160
Query: 93 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
+ +L + V PFLV L ++F+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 161 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 220
Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 221 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 280
Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 268
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 281 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 340
Query: 269 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 328
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P G D +F
Sbjct: 341 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 399
Query: 329 D-DYEEEDIRVSI 340
D ++ EE + SI
Sbjct: 400 DPEFTEEPVPNSI 412
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 269 bits (687), Expect = 3e-72
Identities = 134/313 (42%), Positives = 202/313 (64%), Gaps = 7/313 (2%)
Query: 34 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
P+ N +A DF K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 115 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 174
Query: 93 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
+ +L + V PFLV L ++F+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 175 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 234
Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 235 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 294
Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 268
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 295 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 354
Query: 269 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 328
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P G D +F
Sbjct: 355 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 413
Query: 329 D-DYEEEDIRVSI 340
D ++ EE + SI
Sbjct: 414 DPEFTEEPVPNSI 426
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 269 bits (687), Expect = 3e-72
Identities = 134/313 (42%), Positives = 202/313 (64%), Gaps = 7/313 (2%)
Query: 34 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
P+ N +A DF K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 182 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 241
Query: 93 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
+ +L + V PFLV L ++F+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 242 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 301
Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 302 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 361
Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 268
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 362 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 421
Query: 269 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 328
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P G D +F
Sbjct: 422 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 480
Query: 329 D-DYEEEDIRVSI 340
D ++ EE + SI
Sbjct: 481 DPEFTEEPVPNSI 493
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 268 bits (685), Expect = 5e-72
Identities = 132/293 (45%), Positives = 186/293 (63%), Gaps = 3/293 (1%)
Query: 41 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
+ DF+ K LG G+FG+V+LV+ KAT +YYAMKIL K+ ++ ++ HT+ E R+LQ
Sbjct: 149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR 208
Query: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160
PFL L+YAF+ + L VMEY GGE+F HL R F+E ARFY A+IV EYLHS
Sbjct: 209 HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 268
Query: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYN 217
D++YRD+K ENL++D G+I++TDFG K G T T CGTPEYLAPE++ Y
Sbjct: 269 RDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYG 328
Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVD 277
+AVDWW LGV++YEM G PF+ +++E I+ ++RFP S + K LL LL+ D
Sbjct: 329 RAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKD 388
Query: 278 LTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD 330
+R G + ++ H++F + +W + Q+K+ PF P+ DT FDD
Sbjct: 389 PKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDD 441
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 268 bits (684), Expect = 7e-72
Identities = 134/308 (43%), Positives = 188/308 (61%), Gaps = 4/308 (1%)
Query: 41 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
+ DF+ K LG G+FG+V+LV+ KA+ +YYAMKIL K+ ++ ++ HTL E R+L+
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR 204
Query: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160
PFL L+Y+F+ L VMEYV GGE+F HL R FSE RFY A+IV +YLHS
Sbjct: 205 HPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS 264
Query: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYN 217
++YRDLK ENL++D G+I++TDFG K T CGTPEYLAPE++ Y
Sbjct: 265 GKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYG 324
Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVD 277
+AVDWW LGV++YEM G PF+ +++E I+ ++FP SSD K LL LL D
Sbjct: 325 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKD 384
Query: 278 LTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFD-DYEEEDI 336
KR G + +I H +F+ +W +Y +K+ PF P+ DT FD ++ + I
Sbjct: 385 PNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
Query: 337 RVSITEKC 344
++ EKC
Sbjct: 445 TITPPEKC 452
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 264 bits (675), Expect = 8e-71
Identities = 133/307 (43%), Positives = 187/307 (60%), Gaps = 4/307 (1%)
Query: 41 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
+ DF+ K LG G+FG+V+LV+ KA+ +YYAMKIL K+ ++ ++ HTL E R+L+
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR 204
Query: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160
PFL L+Y+F+ L VMEYV GGE+F HL R FSE RFY A+IV +YLHS
Sbjct: 205 HPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS 264
Query: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYN 217
++YRDLK ENL++D G+I++TDFG K T CGTPEYLAPE++ Y
Sbjct: 265 GKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYG 324
Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVD 277
+AVDWW LGV++YEM G PF+ +++E I+ ++FP SSD K LL LL D
Sbjct: 325 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKD 384
Query: 278 LTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFD-DYEEEDI 336
KR G + +I H +F+ +W +Y +K+ PF P+ DT FD ++ + I
Sbjct: 385 PNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
Query: 337 RVSITEK 343
++ EK
Sbjct: 445 TITPPEK 451
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 264 bits (674), Expect = 1e-70
Identities = 141/338 (41%), Positives = 199/338 (58%), Gaps = 20/338 (5%)
Query: 13 VESVKEFLAKAKEDFLKKWENPTQNNAGLED----------------FERKKTLGTGSFG 56
+++V + L K +E+ + +N+G E+ FE K LG G+FG
Sbjct: 103 IQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFG 162
Query: 57 RVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSN 116
+V+LVK KAT +YYAMKIL K+ +V ++ HTL E R+LQ PFL L+Y+F+ +
Sbjct: 163 KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222
Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLI 175
L VMEY GGE+F HL R FSE ARFY A+IV +YLHS +++YRDLK ENL++
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282
Query: 176 DHQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM 232
D G+I++TDFG K G T T CGTPEYLAPE++ Y +AVDWW LGV++YEM
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342
Query: 233 AAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDI 292
G PF+ +++E I+ ++RFP + K LL LL+ D +R G +I
Sbjct: 343 MCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEI 402
Query: 293 KTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD 330
H++FA W +Y++K+ PF P+ DT FD+
Sbjct: 403 MQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 264 bits (674), Expect = 1e-70
Identities = 141/338 (41%), Positives = 199/338 (58%), Gaps = 20/338 (5%)
Query: 13 VESVKEFLAKAKEDFLKKWENPTQNNAGLED----------------FERKKTLGTGSFG 56
+++V + L K +E+ + +N+G E+ FE K LG G+FG
Sbjct: 103 IQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFG 162
Query: 57 RVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSN 116
+V+LVK KAT +YYAMKIL K+ +V ++ HTL E R+LQ PFL L+Y+F+ +
Sbjct: 163 KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222
Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLI 175
L VMEY GGE+F HL R FSE ARFY A+IV +YLHS +++YRDLK ENL++
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282
Query: 176 DHQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM 232
D G+I++TDFG K G T T CGTPEYLAPE++ Y +AVDWW LGV++YEM
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342
Query: 233 AAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDI 292
G PF+ +++E I+ ++RFP + K LL LL+ D +R G +I
Sbjct: 343 MCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEI 402
Query: 293 KTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD 330
H++FA W +Y++K+ PF P+ DT FD+
Sbjct: 403 MQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 264 bits (674), Expect = 1e-70
Identities = 141/338 (41%), Positives = 199/338 (58%), Gaps = 20/338 (5%)
Query: 13 VESVKEFLAKAKEDFLKKWENPTQNNAGLED----------------FERKKTLGTGSFG 56
+++V + L K +E+ + +N+G E+ FE K LG G+FG
Sbjct: 103 IQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFG 162
Query: 57 RVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSN 116
+V+LVK KAT +YYAMKIL K+ +V ++ HTL E R+LQ PFL L+Y+F+ +
Sbjct: 163 KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222
Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLI 175
L VMEY GGE+F HL R FSE ARFY A+IV +YLHS +++YRDLK ENL++
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282
Query: 176 DHQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM 232
D G+I++TDFG K G T T CGTPEYLAPE++ Y +AVDWW LGV++YEM
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342
Query: 233 AAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDI 292
G PF+ +++E I+ ++RFP + K LL LL+ D +R G +I
Sbjct: 343 MCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEI 402
Query: 293 KTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD 330
H++FA W +Y++K+ PF P+ DT FD+
Sbjct: 403 MQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 264 bits (674), Expect = 1e-70
Identities = 134/313 (42%), Positives = 200/313 (63%), Gaps = 7/313 (2%)
Query: 34 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
P+ N NA DF+ K +G G++G+V+L K K+ +YA+K+L K+ ++K K+ H + E
Sbjct: 24 PSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAE 83
Query: 93 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
+ +L + V PFLV L Y+F+ LY V++YV GGE+F HL+R RF EP ARFYAA++
Sbjct: 84 RSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEV 143
Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
YLHSL++IYRDLKPEN+L+D QG++ +TDFG K + T T CGTPEYLAP
Sbjct: 144 ASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAP 203
Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 268
E++ + Y++AVDWW LG ++YEM G PPF++ Q+YE I+ ++ P + D
Sbjct: 204 EVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACD 263
Query: 269 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 328
LL++LL D +R G+ K +IK H +F+ +W +Y +++ PF P G D +F
Sbjct: 264 LLQSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHF 322
Query: 329 D-DYEEEDIRVSI 340
D ++ +E + SI
Sbjct: 323 DPEFTQEAVSKSI 335
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 264 bits (674), Expect = 1e-70
Identities = 134/313 (42%), Positives = 200/313 (63%), Gaps = 7/313 (2%)
Query: 34 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
P+ N NA DF+ K +G G++G+V+L K K+ +YA+K+L K+ ++K K+ H + E
Sbjct: 84 PSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAE 143
Query: 93 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
+ +L + V PFLV L Y+F+ LY V++YV GGE+F HL+R RF EP ARFYAA++
Sbjct: 144 RSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEV 203
Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
YLHSL++IYRDLKPEN+L+D QG++ +TDFG K + T T CGTPEYLAP
Sbjct: 204 ASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAP 263
Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 268
E++ + Y++AVDWW LG ++YEM G PPF++ Q+YE I+ ++ P + D
Sbjct: 264 EVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACD 323
Query: 269 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 328
LL++LL D +R G+ K +IK H +F+ +W +Y +++ PF P G D +F
Sbjct: 324 LLQSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHF 382
Query: 329 D-DYEEEDIRVSI 340
D ++ +E + SI
Sbjct: 383 DPEFTQEAVSKSI 395
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 254 bits (649), Expect = 8e-68
Identities = 127/296 (42%), Positives = 182/296 (61%), Gaps = 7/296 (2%)
Query: 41 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
L+DF LG G FG+V+L ++K T + +A+K L K +V +++ + EKRI + VN
Sbjct: 654 LQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN 713
Query: 101 ---FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157
PFLV L F+ ++ VMEY GG++ H+ FSEP A FYAA +VL +Y
Sbjct: 714 SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACVVLGLQY 772
Query: 158 LHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSK 214
LH ++YRDLK +NLL+D +G++++ DFG K G RT T CGTPE+LAPE++
Sbjct: 773 LHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTET 832
Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLL 274
Y +AVDWW LGVLIYEM G PF D ++++ IV+ +VR+P S++ ++R LL
Sbjct: 833 SYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLL 892
Query: 275 QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD 330
+ + +R G + D+K H +F DW A+ +KV+ PFIP RG D SNFDD
Sbjct: 893 RRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDD 948
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 250 bits (639), Expect = 1e-66
Identities = 134/344 (38%), Positives = 201/344 (58%), Gaps = 10/344 (2%)
Query: 5 ATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHK 64
A +G++V K +K D N ++ L DF LG GSFG+VML + K
Sbjct: 308 AKISQGTKVPEEKTTNTVSKFD-----NNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERK 362
Query: 65 ATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP-FLVRLEYAFKDNSNLYMVMEY 123
T++ YA+KIL K V++ +E T+ EKR+L P FL +L F+ LY VMEY
Sbjct: 363 GTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEY 422
Query: 124 VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQV 183
V GG++ H++++GRF EPHA FYAA+I + +L S +IYRDLK +N+++D +G+I++
Sbjct: 423 VNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI 482
Query: 184 TDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
DFG K T T CGTP+Y+APEII + Y K+VDWWA GVL+YEM AG PF
Sbjct: 483 ADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 542
Query: 241 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT 300
+ ++++ I+ V +P S + + + L+ KR G G DIK H +F
Sbjct: 543 GEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602
Query: 301 TDWIAIYQRKVEAPFIPKFRGSGDTSNFD-DYEEEDIRVSITEK 343
DW + +++++ P+ PK R DTSNFD ++ + + ++ T+K
Sbjct: 603 IDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDK 646
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 245 bits (626), Expect = 4e-65
Identities = 124/303 (40%), Positives = 180/303 (59%), Gaps = 6/303 (1%)
Query: 43 DFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRIL-QAVNF 101
DF+ K +G GSFG+V+L K K ++YA+K+L K+ V+ K+ +H + E+ +L + V
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161
PFLV L Y+F+ LY V+++V GGE+F HL+R F E ARFYAA+I YLHS+
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 162 DLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNK 218
++YRDLKPEN+L+D G++ +TDFG K + T T CGTPEYLAPE+I + Y+
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 278
VDWW LG ++YEM G PPF+ ++Y+ I+ + S +L LL+ D
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400
Query: 279 TKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD-YEEEDIR 337
R G K +I+ H +F + W + Q+K+ PF P G D NFD + EE +
Sbjct: 401 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVP 459
Query: 338 VSI 340
S+
Sbjct: 460 YSV 462
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 245 bits (626), Expect = 4e-65
Identities = 124/303 (40%), Positives = 180/303 (59%), Gaps = 6/303 (1%)
Query: 43 DFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRIL-QAVNF 101
DF+ K +G GSFG+V+L K K ++YA+K+L K+ V+ K+ +H + E+ +L + V
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161
PFLV L Y+F+ LY V+++V GGE+F HL+R F E ARFYAA+I YLHS+
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 162 DLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNK 218
++YRDLKPEN+L+D G++ +TDFG K + T T CGTPEYLAPE+I + Y+
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 278
VDWW LG ++YEM G PPF+ ++Y+ I+ + S +L LL+ D
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400
Query: 279 TKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD-YEEEDIR 337
R G K +I+ H +F + W + Q+K+ PF P G D NFD + EE +
Sbjct: 401 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVP 459
Query: 338 VSI 340
S+
Sbjct: 460 YSV 462
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 245 bits (625), Expect = 5e-65
Identities = 128/315 (40%), Positives = 191/315 (60%), Gaps = 7/315 (2%)
Query: 35 TQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKR 94
+ N G+++FE + LG GSFG+VML + K T YA+K+L K +++ +E T+ EKR
Sbjct: 346 SSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKR 405
Query: 95 ILQ-AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153
IL A N PFL +L F+ L+ VME+V GG++ H+++ RF E ARFYAA+I+
Sbjct: 406 ILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIIS 465
Query: 154 TFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEI 210
+LH +IYRDLK +N+L+DH+G+ ++ DFG K G T T CGTP+Y+APEI
Sbjct: 466 ALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 525
Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 270
+ Y AVDWWA+GVL+YEM G+ PF A+ ++E I++ +V +P+ D +L
Sbjct: 526 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGIL 585
Query: 271 RNLLQVDLTKRFGNL-KNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFD 329
++ + + T R G+L + G I H +F DW + R++E PF P+ + D SNFD
Sbjct: 586 KSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFD 645
Query: 330 D--YEEEDIRVSITE 342
+EE + I E
Sbjct: 646 PDFIKEEPVLTPIDE 660
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 244 bits (623), Expect = 8e-65
Identities = 124/295 (42%), Positives = 180/295 (61%), Gaps = 5/295 (1%)
Query: 41 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
L DF LG GSFG+VML K TE+ YA+KIL K V++ +E T+ EKR+L ++
Sbjct: 336 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 395
Query: 101 FP-FLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159
P FL +L F+ LY VMEYV GG++ H++++G+F EP A FYAA+I + +LH
Sbjct: 396 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLH 455
Query: 160 SLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEIILSKGY 216
+IYRDLK +N+++D +G+I++ DFG K + G T T CGTP+Y+APEII + Y
Sbjct: 456 KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY 515
Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276
K+VDWWA GVL+YEM AG PPF + ++++ I+ V +P S + + + L+
Sbjct: 516 GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTK 575
Query: 277 DLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDY 331
KR G G D++ H +F DW + R+++ PF PK G G NFD +
Sbjct: 576 HPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKG-AENFDKF 629
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 241 bits (615), Expect = 7e-64
Identities = 125/319 (39%), Positives = 190/319 (59%), Gaps = 8/319 (2%)
Query: 40 GLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQ-A 98
GL++F K LG GSFG+VML + K ++ YA+K+L K +++ ++ T+ EKRIL A
Sbjct: 404 GLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALA 463
Query: 99 VNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158
P+L +L F+ L+ VMEYV GG++ ++R +F EP +RFYAA++ +L
Sbjct: 464 RKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFL 523
Query: 159 HSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEIILSKG 215
H +IYRDLK +N+L+D +G+ ++ DFG K + G T T CGTP+Y+APEI+
Sbjct: 524 HQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELE 583
Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 275
Y +VDWWALGVL+YEM AG PPF AD ++E I+ V +P S + +L+ +
Sbjct: 584 YGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMT 643
Query: 276 VDLTKRFGNL--KNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD--Y 331
+ KR G + +NG IK H +F DW+ + Q+K++ PF P+ + D +NFD
Sbjct: 644 KNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFT 703
Query: 332 EEEDIRVSITEKCAKEFGE 350
EE + + E K+ +
Sbjct: 704 REEPVLTLVDEAIVKQINQ 722
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 239 bits (610), Expect = 3e-63
Identities = 129/307 (42%), Positives = 186/307 (60%), Gaps = 14/307 (4%)
Query: 36 QNNAGLEDFERKKTLGTGSFGRVMLVKHKATE---QYYAMKILDKQKVV-KLKQIEHTLN 91
+ +E+FE K LGTG++G+V LV+ + YAMK+L K +V + K EHT
Sbjct: 25 EEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRT 84
Query: 92 EKRILQAVN-FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 150
E+ +L+ V PFLV L YAF+ ++ L+++++YV GGEMF+HL + F E R Y +
Sbjct: 85 ERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGE 144
Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV----KGRTWTLCGTPEYL 206
IVL E+LH L +IYRDLK EN+L+D +G+I +TDFG +K K RT++ CGT EY+
Sbjct: 145 IVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYM 204
Query: 207 APEIILSK-GYNKAVDWWALGVLIYEMAAGYPPFFAD----QPIQIYEKIVSGKVRFPSH 261
APEII SK G+ KAVDWW+LG+L++E+ G PF + ++ +I+ FP
Sbjct: 205 APEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPR 264
Query: 262 FSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG 321
+DLL+ LL D KR G G +++ H +F DW+A+ RK+ APF P+ R
Sbjct: 265 IGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRS 324
Query: 322 SGDTSNF 328
D NF
Sbjct: 325 ELDVGNF 331
Score = 114 bits (284), Expect = 2e-25
Identities = 82/256 (32%), Positives = 132/256 (51%), Gaps = 26/256 (10%)
Query: 46 RKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV 105
R+ LG GSF + + + Q +A+KIL ++ ++ L R+ Q+ P +V
Sbjct: 407 REPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL---RLCQS--HPNVV 461
Query: 106 RLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLI 164
L D + Y+V+E + GGE+ H+R+ FSE A +V ++H ++
Sbjct: 462 NLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVV 521
Query: 165 YRDLKPENLLI--DHQGY-IQVTDFGFAKRVKGRT-----WTLCGTPEYLAPEIILSKGY 216
+RDLKPEN+L D G +++ DFGFA R++ ++ T C T +Y APE++ +GY
Sbjct: 522 HRDLKPENILYADDTPGAPVKIIDFGFA-RLRPQSPGVPMQTPCFTLQYAAPELLAQQGY 580
Query: 217 NKAVDWWALGVLIYEMAAGYPPFFA-------DQPIQIYEKIVSGKVRFPSH----FSSD 265
+++ D W+LGV++Y M +G PF Q +I KI G+ S +
Sbjct: 581 DESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEE 640
Query: 266 LKDLLRNLLQVDLTKR 281
K+L+R LL VD KR
Sbjct: 641 AKELVRGLLTVDPAKR 656
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,978,722
Number of Sequences: 37866
Number of extensions: 564647
Number of successful extensions: 3498
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 713
Number of HSP's successfully gapped in prelim test: 86
Number of HSP's that attempted gapping in prelim test: 1181
Number of HSP's gapped (non-prelim): 897
length of query: 351
length of database: 18,247,518
effective HSP length: 103
effective length of query: 248
effective length of database: 14,347,320
effective search space: 3558135360
effective search space used: 3558135360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.