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Search of human proteins with 127139033
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|127139033 cytochrome P450 reductase [Homo sapiens]
(680 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|127139033 cytochrome P450 reductase [Homo sapiens] 1375 0.0
gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [... 292 8e-79
gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a... 284 2e-76
gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c... 280 4e-75
gi|24041029 nitric oxide synthase 2A [Homo sapiens] 258 2e-68
gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d... 258 2e-68
gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens] 250 3e-66
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens] 246 4e-65
gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens] 211 2e-54
gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens] 211 2e-54
gi|50726981 radical S-adenosyl methionine and flavodoxin domains... 105 1e-22
gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1 ... 83 1e-15
gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens] 42 0.002
gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens] 40 0.005
gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens] 40 0.005
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens] 34 0.51
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens] 33 0.66
gi|21359846 prospero homeobox 1 [Homo sapiens] 33 0.87
gi|154448896 exportin 7 isoform c [Homo sapiens] 32 2.5
gi|154448894 exportin 7 isoform a [Homo sapiens] 32 2.5
gi|154448892 exportin 7 isoform b [Homo sapiens] 32 2.5
gi|11056032 protocadherin gamma subfamily A, 1 isoform 1 precurs... 32 2.5
gi|14196459 protocadherin gamma subfamily A, 1 isoform 2 precurs... 32 2.5
gi|157676331 hyaluronan binding protein 4 [Homo sapiens] 31 3.3
>gi|127139033 cytochrome P450 reductase [Homo sapiens]
Length = 680
Score = 1375 bits (3559), Expect = 0.0
Identities = 680/680 (100%), Positives = 680/680 (100%)
Query: 1 MINMGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKI 60
MINMGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKI
Sbjct: 1 MINMGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKI 60
Query: 61 QTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEY 120
QTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEY
Sbjct: 61 QTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEY 120
Query: 121 DLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKT 180
DLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKT
Sbjct: 121 DLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKT 180
Query: 181 YEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATG 240
YEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATG
Sbjct: 181 YEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATG 240
Query: 241 EESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE 300
EESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE
Sbjct: 241 EESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE 300
Query: 301 RHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNK 360
RHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNK
Sbjct: 301 RHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNK 360
Query: 361 KHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYL 420
KHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYL
Sbjct: 361 KHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYL 420
Query: 421 SWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVE 480
SWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVE
Sbjct: 421 SWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVE 480
Query: 481 YETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGV 540
YETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGV
Sbjct: 481 YETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGV 540
Query: 541 APFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSR 600
APFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSR
Sbjct: 541 APFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSR 600
Query: 601 EQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQ 660
EQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQ
Sbjct: 601 EQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQ 660
Query: 661 AVDYIKKLMTKGRYSLDVWS 680
AVDYIKKLMTKGRYSLDVWS
Sbjct: 661 AVDYIKKLMTKGRYSLDVWS 680
>gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b
[Homo sapiens]
Length = 597
Score = 292 bits (747), Expect = 8e-79
Identities = 197/609 (32%), Positives = 313/609 (51%), Gaps = 28/609 (4%)
Query: 83 IIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMAT 142
++V +GSQTGTA++ + RL ++A R + + Y + +L I+ LV+F AT
Sbjct: 6 LLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNL-----INEPLVIFVCAT 60
Query: 143 YGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLG 199
G+GDP DN ++F+ ++ ++ L + FAV GLG+ +Y FN + K + +RL QLG
Sbjct: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
Query: 200 AQRIFELGLGDDDGNLEEDFIT--WREQFWPAVCEHFGVEA--TGEESSIRQYELVVHTD 255
+ + LGDD L D W W V + T +
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
Query: 256 IDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE-RHLMHLELDISDSK 314
+ A E R+ +Q+PP ++K PFLA + +N+++ + + + +E DI S
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESK-PFLAPMISNQRVTGPSHFQDVRLIEFDILGSG 239
Query: 315 IRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTAL 374
I + +GD V + P+N +A V + ++LG D D + L + + + P P S R +
Sbjct: 240 ISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLV 299
Query: 375 TYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAIL 434
++YLDI + PR + LA + E+E L + SS +G+E + RR IL +L
Sbjct: 300 SHYLDIASVPRRSFFELLACLSLHELEREKL--LEFSSAQGQEELFEYCNRPRRTILEVL 357
Query: 435 QDCP--SLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGV 492
D P + P D+L +L+P ++ R +SIASS HP+ + I VV+++T+ +G+
Sbjct: 358 CDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGL 417
Query: 493 ATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAW 552
++WL + +P G VP++VR P TPVIMVGPGTGVAPF IQER
Sbjct: 418 CSSWLASLDP---GQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA 474
Query: 553 LRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLL 612
Q G L++GCR D+D+ + E + + LT L AFSREQ KVYVQH L
Sbjct: 475 QGQTG-----NFLFFGCRWRDQDFYWEAEWQELEKRDCLT-LIPAFSREQEQKVYVQHRL 528
Query: 613 KQDREHLWKLIE-GGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTK 671
++ +W+L++ GA+ Y+ G+A++M DV I E G + A Y+ +L
Sbjct: 529 RELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQT 588
Query: 672 GRYSLDVWS 680
R+ + W+
Sbjct: 589 RRFQTETWA 597
>gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a
[Homo sapiens]
Length = 606
Score = 284 bits (727), Expect = 2e-76
Identities = 197/618 (31%), Positives = 313/618 (50%), Gaps = 37/618 (5%)
Query: 83 IIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMAT 142
++V +GSQTGTA++ + RL ++A R + + Y + +L I+ LV+F AT
Sbjct: 6 LLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNL-----INEPLVIFVCAT 60
Query: 143 YGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLG 199
G+GDP DN ++F+ ++ ++ L + FAV GLG+ +Y FN + K + +RL QLG
Sbjct: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
Query: 200 AQRIFELGLGDDDGNLEEDFIT--WREQFWPAVCEHFGVEA--TGEESSIRQYELVVHTD 255
+ + LGDD L D W W V + T +
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
Query: 256 IDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE-RHLMHLELDISDSK 314
+ A E R+ +Q+PP ++K PFLA + +N+++ + + + +E DI S
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESK-PFLAPMISNQRVTGPSHFQDVRLIEFDILGSG 239
Query: 315 IRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTAL 374
I + +GD V + P+N +A V + ++LG D D + L + + + P P S R +
Sbjct: 240 ISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLV 299
Query: 375 TYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAIL 434
++YLDI + PR + LA + E+E L + SS +G+E + RR IL +L
Sbjct: 300 SHYLDIASVPRRSFFELLACLSLHELEREKL--LEFSSAQGQEELFEYCNRPRRTILEVL 357
Query: 435 QDCP--SLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGV 492
D P + P D+L +L+P ++ R +SIASS HP+ + I VV+++T+ +G+
Sbjct: 358 CDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGL 417
Query: 493 ATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAW 552
++WL + +P G VP++VR P TPVIMVGPGTGVAPF IQER
Sbjct: 418 CSSWLASLDP---GQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA 474
Query: 553 LRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSRE---------QS 603
Q G L++GCR D+D+ + E + + LT L AFSRE Q
Sbjct: 475 QGQTG-----NFLFFGCRWRDQDFYWEAEWQELEKRDCLT-LIPAFSREQPPALFSALQE 528
Query: 604 HKVYVQHLLKQDREHLWKLIE-GGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAV 662
KVYVQH L++ +W+L++ GA+ Y+ G+A++M DV I E G + A
Sbjct: 529 QKVYVQHRLRELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAA 588
Query: 663 DYIKKLMTKGRYSLDVWS 680
Y+ +L R+ + W+
Sbjct: 589 AYLARLQQTRRFQTETWA 606
>gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c
[Homo sapiens]
Length = 590
Score = 280 bits (715), Expect = 4e-75
Identities = 195/609 (32%), Positives = 310/609 (50%), Gaps = 35/609 (5%)
Query: 83 IIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMAT 142
++V +GSQTGTA++ + RL ++A R + + Y + +L I+ LV+F AT
Sbjct: 6 LLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNL-----INEPLVIFVCAT 60
Query: 143 YGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLG 199
G+GDP DN ++F+ ++ ++ L + FAV GLG+ +Y FN + K + +RL QLG
Sbjct: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
Query: 200 AQRIFELGLGDDDGNLEEDFIT--WREQFWPAVCEHFGVEA--TGEESSIRQYELVVHTD 255
+ + LGDD L D W W V + T +
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
Query: 256 IDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE-RHLMHLELDISDSK 314
+ A E R+ +Q+PP ++K PFLA + +N+++ + + + +E DI S
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESK-PFLAPMISNQRVTGPSHFQDVRLIEFDILGSG 239
Query: 315 IRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTAL 374
I + +GD V + P+N +A V + ++LG D D + L + + + P P S R +
Sbjct: 240 ISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLV 299
Query: 375 TYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAIL 434
++YLDI + PR + LA + E+E L + SS +G+E + RR IL +L
Sbjct: 300 SHYLDIASVPRRSFFELLACLSLHELEREKL--LEFSSAQGQEELFEYCNRPRRTILEVL 357
Query: 435 QDCP--SLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGV 492
D P + P D+L +L+P ++ R +SIAS S+ I VV+++T+ +G+
Sbjct: 358 CDFPHTAAAIPPDYLLDLIPVIRPRAFSIAS-------SLLILVAVVQFQTRLKEPRRGL 410
Query: 493 ATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAW 552
++WL + +P G VP++VR P TPVIMVGPGTGVAPF IQER
Sbjct: 411 CSSWLASLDP---GQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA 467
Query: 553 LRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLL 612
Q G L++GCR D+D+ + E + + LT L AFSREQ KVYVQH L
Sbjct: 468 QGQTG-----NFLFFGCRWRDQDFYWEAEWQELEKRDCLT-LIPAFSREQEQKVYVQHRL 521
Query: 613 KQDREHLWKLIE-GGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTK 671
++ +W+L++ GA+ Y+ G+A++M DV I E G + A Y+ +L
Sbjct: 522 RELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQT 581
Query: 672 GRYSLDVWS 680
R+ + W+
Sbjct: 582 RRFQTETWA 590
>gi|24041029 nitric oxide synthase 2A [Homo sapiens]
Length = 1153
Score = 258 bits (658), Expect = 2e-68
Identities = 207/651 (31%), Positives = 312/651 (47%), Gaps = 48/651 (7%)
Query: 48 RKKKEEVPEFTKIQTLTSSVRESSFVEKMKKTGR-NIIVFYGSQTGTAEEFANRLSKDAH 106
R K+ E+P ++ L +V + + + R + + + ++TG +E A L
Sbjct: 507 RPKRREIP----LKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDLG---- 558
Query: 107 RYGMRGMSADPEEY--DLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDV 164
+ + +P+ D LS L E LVV +T+G GD N + L
Sbjct: 559 --ALFSCAFNPKVVCMDKYRLSCLEEERLLLVV--TSTFGNGDCPGNGEKLKKSLFMLKE 614
Query: 165 DLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWRE 224
+ ++AVFGLG+ Y F A +D++L LGA ++ +G GD+ E+ F +W
Sbjct: 615 LNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAV 674
Query: 225 QFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNP 284
Q + A CE F V + Y V D ++ + + AKN
Sbjct: 675 QTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLV--QDSQPLDLSKALSSMHAKNV 732
Query: 285 FLAAVTTNRKLNQGT-ERHLMHLELDISDSK-IRYESGDHVAVYPANDSALVNQLGK--I 340
F + + + L T R + +EL D + + Y G+H+ V P N ALV + + +
Sbjct: 733 FTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERVV 792
Query: 341 LGADLDVVMSLNNLDEE-----SNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQY 395
G + L LDE S+K+ P P S ALTY+LDIT PP +L +LAQ
Sbjct: 793 DGPTPHQTVRLEALDESGSYWVSDKRLP---PCSLSQALTYFLDITTPPTQLLLQKLAQV 849
Query: 396 ASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQ 455
A+E E++ L + S Y W L +L++ PSLR L LP L+
Sbjct: 850 ATEEPERQRLEALCQPSE-----YSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILK 904
Query: 456 ARYYSIASSSKVHPNSVHICAVVVEYETKAGR--INKGVATNWLRAKEPAGENGGRALVP 513
R+YSI+SS P +H+ VV Y T+ G+ ++ GV + WL + +P VP
Sbjct: 905 PRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDP------VP 958
Query: 514 MFVRK-SQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQ-QGKEVGETLLYYGCRR 571
FVR S F LP + P I++GPGTG+APF F Q+R Q +G G L +GCRR
Sbjct: 959 CFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRR 1018
Query: 572 SDEDYLYREELAQFHRDGALTQLNVAFSR-EQSHKVYVQHLLKQD--REHLWKLIEGGAH 628
DED++Y+EE+ + + G L ++ A+SR KVYVQ +L+Q E L L + H
Sbjct: 1019 PDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGH 1078
Query: 629 IYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVW 679
+YVCGD R MARDV +T +VA + Q DY +L ++ RY D++
Sbjct: 1079 LYVCGDVR-MARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIF 1128
>gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d
[Homo sapiens]
Length = 521
Score = 258 bits (658), Expect = 2e-68
Identities = 180/550 (32%), Positives = 283/550 (51%), Gaps = 57/550 (10%)
Query: 83 IIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMAT 142
++V +GSQTGTA++ + RL ++A R + + Y + +L I+ LV+F AT
Sbjct: 6 LLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNL-----INEPLVIFVCAT 60
Query: 143 YGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLG 199
G+GDP DN ++F+ ++ ++ L + FAV GLG+ +Y FN + K + +RL QLG
Sbjct: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
Query: 200 AQRIFELGLGDDDGNL--EEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDID 257
+ + LGDD L F Q P+ TG E
Sbjct: 121 GSALLPVCLGDDQHELGLPSKFTLLFLQEAPS---------TGSEGQ------------- 158
Query: 258 AAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE-RHLMHLELDISDSKIR 316
R+ +Q+PP ++K PFLA + +N+++ + + + +E DI S I
Sbjct: 159 ----------RVAHPGSQEPPSESK-PFLAPMISNQRVTGPSHFQDVRLIEFDILGSGIS 207
Query: 317 YESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTY 376
+ +GD V + P+N +A V + ++LG D D + L + + + P P S R +++
Sbjct: 208 FAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVSH 267
Query: 377 YLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQD 436
YLDI + PR + LA + E+E L + SS +G+E + RR IL +L D
Sbjct: 268 YLDIASVPRRSFFELLACLSLHELEREKL--LEFSSAQGQEELFEYCNRPRRTILEVLCD 325
Query: 437 CP--SLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVAT 494
P + P D+L +L+P ++ R +SIASS HP+ + I VV+++T+ +G+ +
Sbjct: 326 FPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCS 385
Query: 495 NWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLR 554
+WL + +P G VP++VR P TPVIMVGPGTGVAPF IQER
Sbjct: 386 SWLASLDP---GQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQG 442
Query: 555 QQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQ 614
Q G L++GCR D+D+ + E + + LT L AFSREQ KVYVQH L++
Sbjct: 443 QTG-----NFLFFGCRWRDQDFYWEAEWQELEKRDCLT-LIPAFSREQEQKVYVQHRLRE 496
Query: 615 DREHLWKLIE 624
+W+L++
Sbjct: 497 LGSLVWELLD 506
>gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]
Length = 1203
Score = 250 bits (639), Expect = 3e-66
Identities = 213/712 (29%), Positives = 331/712 (46%), Gaps = 125/712 (17%)
Query: 50 KKEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHR-Y 108
+K+ E +++S+ + +++K T + YGS+TG A+ +A +L + + +
Sbjct: 492 RKKTFKEVANAVKISASLMGTVMAKRVKAT-----ILYGSETGRAQSYAQQLGRLFRKAF 546
Query: 109 GMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQE------- 161
R + D EYD+ L LV+ +T+G GDP +N + F L E
Sbjct: 547 DPRVLCMD--EYDVVSLEH-----ETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNS 599
Query: 162 ----------------------------------TDVDLSG----VKFAVFGLGNKTYEH 183
++ D +G ++F VFGLG++ Y H
Sbjct: 600 SPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPH 659
Query: 184 FNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEES 243
F A + VD RLE+LG +R+ +LG GD+ EE F W + + A CE F V GE++
Sbjct: 660 FCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCV---GEDA 716
Query: 244 SIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAV-----TTNRKLNQG 298
DI + K +S++ Q+ A+ L + RK+ Q
Sbjct: 717 K------AAARDIFSPK---------RSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQA 761
Query: 299 TERHLMHLE------------LDISDSK-IRYESGDHVAVYPANDSALVNQLGKILG--- 342
T R + +L+ LD + ++Y+ GDH+ V P N LV L +
Sbjct: 762 TIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPP 821
Query: 343 ADLDVVMSLNNLDEESNK-------KHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQY 395
A + V ++ L++ S + P P + R ALT++LDIT+PP +L L+
Sbjct: 822 APTEPV-AVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTL 880
Query: 396 ASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQ 455
A EP EQ+ L ++ + Y W +L +L+ PS+ P L LP LQ
Sbjct: 881 AEEPREQQELEALS----QDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQ 936
Query: 456 ARYYSIASSSKVHPNSVHICAVVVEYETK--AGRINKGVATNWLRAKEPAGENGGRALVP 513
RYYS++S+ HP +H+ V+ Y T+ G ++ GV + WL +P VP
Sbjct: 937 PRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGDP------VP 990
Query: 514 MFVRKS-QFRLPFKATTPVIMVGPGTGVAPFIGFIQERAW-LRQQGKEVGETLLYYGCRR 571
F+R + FRLP + P I+VGPGTG+APF GF QER + +G + L +GCR
Sbjct: 991 CFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTLVFGCRC 1050
Query: 572 SDEDYLYREELAQFHRDGALTQLNVAFSREQSH-KVYVQHLLKQD---REHLWKLIEGGA 627
S D+LYR+E+ + G ++ AFSRE + K YVQ +L+ + H +E G
Sbjct: 1051 SQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVLCLERG- 1109
Query: 628 HIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVW 679
H++VCGD MA +V T I+A G ME +A D I L + RY D++
Sbjct: 1110 HMFVCGDV-TMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIF 1160
>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
Length = 1434
Score = 246 bits (629), Expect = 4e-65
Identities = 195/675 (28%), Positives = 309/675 (45%), Gaps = 116/675 (17%)
Query: 85 VFYGSQTGTAEEFANRLSKD-AHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATY 143
+ Y ++TG ++ +A L + H + + MS EEYD+ L LV+ +T+
Sbjct: 762 ILYATETGKSQAYAKTLCEIFKHAFDAKVMSM--EEYDIVHLEH-----ETLVLVVTSTF 814
Query: 144 GEGDPTDNAQDF-----------------------------YDWLQETDVD--------- 165
G GDP +N + F Y Q++ D
Sbjct: 815 GNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFE 874
Query: 166 ----LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFIT 221
L+ V+F+VFGLG++ Y HF A G VD LE+LG +RI ++ GD+ EE F T
Sbjct: 875 SAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRT 934
Query: 222 WREQFWPAVCEHFGV-----------EATGEESSIRQYELVVHTDIDAAKVYMG------ 264
W ++ + A C+ F V + S ++ + + +A ++ G
Sbjct: 935 WAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHK 994
Query: 265 ---EMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGD 321
RL S +N + P +++ + TN +++Y+ GD
Sbjct: 995 KRVSAARLLSRQNLQSPKSSRSTIFVRLHTN------------------GSQELQYQPGD 1036
Query: 322 HVAVYPANDSALVNQLGKIL--GADLDVVMSLNNLDEESNKKHPFPC--------PTSYR 371
H+ V+P N LVN L + L ++ ++ + L+E + P +
Sbjct: 1037 HLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIF 1096
Query: 372 TALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHIL 431
A YYLDIT PP L + A A+ E++ L ++ +G + Y W I+
Sbjct: 1097 QAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLS----KGLQEYEEWKWGKNPTIV 1152
Query: 432 AILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGR--IN 489
+L++ PS++ P L L LQ RYYSI+SS ++P+ VH+ +V Y T+ G I+
Sbjct: 1153 EVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIH 1212
Query: 490 KGVATNWLRAKEPAGENGGRALVPMFVRKS-QFRLPFKATTPVIMVGPGTGVAPFIGFIQ 548
GV ++WL + LVP FVR + F LP P I+VGPGTG+APF F Q
Sbjct: 1213 HGVCSSWLNRIQ------ADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQ 1266
Query: 549 ERAW-LRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSRE-QSHKV 606
+R + ++ +G +L +GCR+S D++YREE Q G +L A+SRE K
Sbjct: 1267 QRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKK 1326
Query: 607 YVQHLLKQD-REHLWK-LIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDY 664
YVQ +L++ E +++ L E G HIYVCGD MA DV I+ + G + A +
Sbjct: 1327 YVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVF 1385
Query: 665 IKKLMTKGRYSLDVW 679
I ++ RY D++
Sbjct: 1386 ISRMRDDNRYHEDIF 1400
>gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]
Length = 698
Score = 211 bits (536), Expect = 2e-54
Identities = 147/448 (32%), Positives = 227/448 (50%), Gaps = 37/448 (8%)
Query: 263 MGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDH 322
+G+ S + P F +TTN + + + +ELDIS++ Y+ GD
Sbjct: 258 LGQEESQVSVTSADPVFQVPISKAVQLTTNDAI-----KTTLLVELDISNTDFSYQPGDA 312
Query: 323 VAVY-PANDSALVNQLGKILGADLDVVMSLNNLDEESNKK-----HPFPCPTSYRTALTY 376
+V P +DS + + L ++ D L + ++ KK P S + T+
Sbjct: 313 FSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTW 372
Query: 377 YLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQD 436
L+I P+ L L Y S+ +E+ L+++ S G Y +V +A +L +L
Sbjct: 373 CLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAAD--YSRFVRDACACLLDLLLA 430
Query: 437 CPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGR--INKGVAT 494
PS +PP+ L E LP+LQ R YS ASSS HP +H +VE+ + A + KGV T
Sbjct: 431 FPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCT 490
Query: 495 NWLRAK---------EPAGENGGRALVPMFV----RKSQFRLPFKATTPVIMVGPGTGVA 541
WL + E+ G+AL P + F LP + P+IMVGPGTG+A
Sbjct: 491 GWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIA 550
Query: 542 PFIGFIQERAWLRQQGKE--VGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFS 599
PFIGF+Q R L++Q + G L++GCR D DYL+R+EL F + G LT L V+FS
Sbjct: 551 PFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFS 610
Query: 600 R------EQSHKVYVQHLLKQDREHLWK-LIEGGAHIYVCGDARNMARDVQNTFYDIVAE 652
R E++ YVQ ++ + + + L++ HIYVCGDA+NMA+DV + I+++
Sbjct: 611 RDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISK 670
Query: 653 LGAMEHAQAVDYIKKLMTKGRYSLDVWS 680
+E +A+ + L + RY D+WS
Sbjct: 671 EVGVEKLEAMKTLATLKEEKRYLQDIWS 698
Score = 81.3 bits (199), Expect = 3e-15
Identities = 51/167 (30%), Positives = 82/167 (49%), Gaps = 7/167 (4%)
Query: 81 RNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCM 140
R ++ Y +Q G A+ A + + A +G E D DL + + A +V +
Sbjct: 2 RRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKT----ETAPLVVVV 57
Query: 141 ATYGEGDPTDNAQDFYDWLQETDVDL---SGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQ 197
+T G GDP D A+ F +Q + + + +++ + GLG+ Y +F GK +DKRL++
Sbjct: 58 STTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQE 117
Query: 198 LGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESS 244
LGA+ ++ G DD LE W WPA+ +HF EE S
Sbjct: 118 LGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEIS 164
>gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]
Length = 725
Score = 211 bits (536), Expect = 2e-54
Identities = 147/448 (32%), Positives = 227/448 (50%), Gaps = 37/448 (8%)
Query: 263 MGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDH 322
+G+ S + P F +TTN + + + +ELDIS++ Y+ GD
Sbjct: 285 LGQEESQVSVTSADPVFQVPISKAVQLTTNDAI-----KTTLLVELDISNTDFSYQPGDA 339
Query: 323 VAVY-PANDSALVNQLGKILGADLDVVMSLNNLDEESNKK-----HPFPCPTSYRTALTY 376
+V P +DS + + L ++ D L + ++ KK P S + T+
Sbjct: 340 FSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTW 399
Query: 377 YLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQD 436
L+I P+ L L Y S+ +E+ L+++ S G Y +V +A +L +L
Sbjct: 400 CLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAAD--YSRFVRDACACLLDLLLA 457
Query: 437 CPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGR--INKGVAT 494
PS +PP+ L E LP+LQ R YS ASSS HP +H +VE+ + A + KGV T
Sbjct: 458 FPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCT 517
Query: 495 NWLRAK---------EPAGENGGRALVPMFV----RKSQFRLPFKATTPVIMVGPGTGVA 541
WL + E+ G+AL P + F LP + P+IMVGPGTG+A
Sbjct: 518 GWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIA 577
Query: 542 PFIGFIQERAWLRQQGKE--VGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFS 599
PFIGF+Q R L++Q + G L++GCR D DYL+R+EL F + G LT L V+FS
Sbjct: 578 PFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFS 637
Query: 600 R------EQSHKVYVQHLLKQDREHLWK-LIEGGAHIYVCGDARNMARDVQNTFYDIVAE 652
R E++ YVQ ++ + + + L++ HIYVCGDA+NMA+DV + I+++
Sbjct: 638 RDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISK 697
Query: 653 LGAMEHAQAVDYIKKLMTKGRYSLDVWS 680
+E +A+ + L + RY D+WS
Sbjct: 698 EVGVEKLEAMKTLATLKEEKRYLQDIWS 725
Score = 82.0 bits (201), Expect = 2e-15
Identities = 53/177 (29%), Positives = 85/177 (48%), Gaps = 7/177 (3%)
Query: 71 SFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPE 130
SF + R ++ Y +Q G A+ A + + A +G E D DL +
Sbjct: 19 SFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKT--- 75
Query: 131 IDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDL---SGVKFAVFGLGNKTYEHFNAM 187
+ A +V ++T G GDP D A+ F +Q + + + +++ + GLG+ Y +F
Sbjct: 76 -ETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNG 134
Query: 188 GKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESS 244
GK +DKRL++LGA+ ++ G DD LE W WPA+ +HF EE S
Sbjct: 135 GKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEIS 191
>gi|50726981 radical S-adenosyl methionine and flavodoxin domains 1
[Homo sapiens]
Length = 732
Score = 105 bits (263), Expect = 1e-22
Identities = 63/156 (40%), Positives = 87/156 (55%), Gaps = 14/156 (8%)
Query: 85 VFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYG 144
+FYGSQTGTA+ FA L++ + + +EYD D + VF +ATY
Sbjct: 81 IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140
Query: 145 EGDPTDNAQDFYDWLQETDVD-------LSGVKFAVFGLGNKTY-EHFNAMGKYVDKRLE 196
+G PT++A+ F WL+E +D L G+++AVFGLGN Y HFN +GK VDK L
Sbjct: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200
Query: 197 QLGAQRIFELGLGDDD------GNLEEDFITWREQF 226
LGA R+ G GD D G++E DF W+ +F
Sbjct: 201 MLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKF 236
>gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1
[Homo sapiens]
Length = 668
Score = 82.8 bits (203), Expect = 1e-15
Identities = 48/125 (38%), Positives = 72/125 (57%), Gaps = 19/125 (15%)
Query: 116 DPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVD-------LSG 168
DP+++ + +++S + VF +ATY +G PT++A+ F WL+E +D L G
Sbjct: 71 DPDDHLIEEVTS-----KNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKG 125
Query: 169 VKFAVFGLGNKTY-EHFNAMGKYVDKRLEQLGAQRIFELGLGDDD------GNLEEDFIT 221
++ AVFGLGN Y HFN +GK VDK L LG R+ G GD D G++E +F
Sbjct: 126 MRDAVFGLGNSAYASHFNKVGKNVDKWLWMLGVHRVMSRGEGDCDVVKSKHGSIEANFRA 185
Query: 222 WREQF 226
W+ +F
Sbjct: 186 WKTKF 190
>gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]
Length = 629
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/110 (25%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 50 KKEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHR-Y 108
+K+ E +++S+ + +++K T + YGS+TG A+ +A +L + + +
Sbjct: 492 RKKTFKEVANAVKISASLMGTVMAKRVKAT-----ILYGSETGRAQSYAQQLGRLFRKAF 546
Query: 109 GMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDW 158
R + D EYD+ L LV+ +T+G GDP +N + W
Sbjct: 547 DPRVLCMD--EYDVVSLEH-----ETLVLVVTSTFGNGDPPENGEGLTLW 589
>gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]
Length = 614
Score = 40.4 bits (93), Expect = 0.005
Identities = 27/105 (25%), Positives = 52/105 (49%), Gaps = 13/105 (12%)
Query: 50 KKEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHR-Y 108
+K+ E +++S+ + +++K T + YGS+TG A+ +A +L + + +
Sbjct: 492 RKKTFKEVANAVKISASLMGTVMAKRVKAT-----ILYGSETGRAQSYAQQLGRLFRKAF 546
Query: 109 GMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQ 153
R + D EYD+ L LV+ +T+G GDP +N +
Sbjct: 547 DPRVLCMD--EYDVVSLE-----HETLVLVVTSTFGNGDPPENGE 584
>gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]
Length = 596
Score = 40.4 bits (93), Expect = 0.005
Identities = 27/105 (25%), Positives = 52/105 (49%), Gaps = 13/105 (12%)
Query: 50 KKEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHR-Y 108
+K+ E +++S+ + +++K T + YGS+TG A+ +A +L + + +
Sbjct: 492 RKKTFKEVANAVKISASLMGTVMAKRVKAT-----ILYGSETGRAQSYAQQLGRLFRKAF 546
Query: 109 GMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQ 153
R + D EYD+ L LV+ +T+G GDP +N +
Sbjct: 547 DPRVLCMD--EYDVVSLE-----HETLVLVVTSTFGNGDPPENGE 584
>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
Length = 1390
Score = 33.9 bits (76), Expect = 0.51
Identities = 38/154 (24%), Positives = 62/154 (40%), Gaps = 16/154 (10%)
Query: 383 PPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRP 442
PP T A+E S+ + +++A +G + WV E+ R + + +RP
Sbjct: 468 PPGTGKTLVARALANECSQGD--KRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRP 525
Query: 443 PI---DHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRA 499
I D + L P +R ++H + V +++ G I ATN L +
Sbjct: 526 SIIFFDEIDGLAPVRSSR------QDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDS 579
Query: 500 KEPAGENGGRALVPMFVRKSQFRLPFKATTPVIM 533
+PA GR F R+ F LP K I+
Sbjct: 580 IDPALRRPGR-----FDREFLFSLPDKEARKEIL 608
>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
Length = 1458
Score = 33.5 bits (75), Expect = 0.66
Identities = 37/145 (25%), Positives = 59/145 (40%), Gaps = 16/145 (11%)
Query: 383 PPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRP 442
PP T A+E S+ + +K+A +G + WV E+ R + + +RP
Sbjct: 442 PPGTGKTLVARALANECSQGD--KKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRP 499
Query: 443 PI---DHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRA 499
I D + L P +R ++H + V +++ G I ATN L +
Sbjct: 500 SIIFFDEIDGLAPVRSSR------QDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDS 553
Query: 500 KEPAGENGGRALVPMFVRKSQFRLP 524
+PA GR F R+ F LP
Sbjct: 554 IDPALRRPGR-----FDREFLFNLP 573
>gi|21359846 prospero homeobox 1 [Homo sapiens]
Length = 737
Score = 33.1 bits (74), Expect = 0.87
Identities = 28/118 (23%), Positives = 45/118 (38%), Gaps = 7/118 (5%)
Query: 201 QRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAK 260
+R ++G+ G F R F+ A+ G E + +Y +V H D + +
Sbjct: 16 RRRVDIGVKRTVGTASAFFAKARATFFSAM------NPQGSEQDV-EYSVVQHADGEKSN 68
Query: 261 VYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYE 318
V + R SYE+ PF + N N GTE L + S++ E
Sbjct: 69 VLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQE 126
>gi|154448896 exportin 7 isoform c [Homo sapiens]
Length = 1088
Score = 31.6 bits (70), Expect = 2.5
Identities = 45/182 (24%), Positives = 83/182 (45%), Gaps = 23/182 (12%)
Query: 289 VTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVV 348
+T +RK+ + +S + ++ SG ++ + + L+ QL K+ L+
Sbjct: 172 LTKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFD 231
Query: 349 MSLNNLDEESNKKHPFPCPTSYRTA------LTYYLDITN--PPRTN--VLYELAQYASE 398
+ DE S+ PTS+R+A L + D+ + PP + VL L Q AS
Sbjct: 232 FIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIAS- 290
Query: 399 PSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDH--LCELLPRLQA 456
+R+ ++ E + +LS +V+ + IL++ SL P ++ C LL RL++
Sbjct: 291 ------VRRSLFNNAE-RAKFLSHLVDG---VKRILENPQSLSDPNNYHEFCRLLARLKS 340
Query: 457 RY 458
Y
Sbjct: 341 NY 342
>gi|154448894 exportin 7 isoform a [Homo sapiens]
Length = 1096
Score = 31.6 bits (70), Expect = 2.5
Identities = 45/182 (24%), Positives = 83/182 (45%), Gaps = 23/182 (12%)
Query: 289 VTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVV 348
+T +RK+ + +S + ++ SG ++ + + L+ QL K+ L+
Sbjct: 180 LTKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFD 239
Query: 349 MSLNNLDEESNKKHPFPCPTSYRTA------LTYYLDITN--PPRTN--VLYELAQYASE 398
+ DE S+ PTS+R+A L + D+ + PP + VL L Q AS
Sbjct: 240 FIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIAS- 298
Query: 399 PSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDH--LCELLPRLQA 456
+R+ ++ E + +LS +V+ + IL++ SL P ++ C LL RL++
Sbjct: 299 ------VRRSLFNNAE-RAKFLSHLVDG---VKRILENPQSLSDPNNYHEFCRLLARLKS 348
Query: 457 RY 458
Y
Sbjct: 349 NY 350
>gi|154448892 exportin 7 isoform b [Homo sapiens]
Length = 1087
Score = 31.6 bits (70), Expect = 2.5
Identities = 45/182 (24%), Positives = 83/182 (45%), Gaps = 23/182 (12%)
Query: 289 VTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVV 348
+T +RK+ + +S + ++ SG ++ + + L+ QL K+ L+
Sbjct: 171 LTKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFD 230
Query: 349 MSLNNLDEESNKKHPFPCPTSYRTA------LTYYLDITN--PPRTN--VLYELAQYASE 398
+ DE S+ PTS+R+A L + D+ + PP + VL L Q AS
Sbjct: 231 FIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIAS- 289
Query: 399 PSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDH--LCELLPRLQA 456
+R+ ++ E + +LS +V+ + IL++ SL P ++ C LL RL++
Sbjct: 290 ------VRRSLFNNAE-RAKFLSHLVDG---VKRILENPQSLSDPNNYHEFCRLLARLKS 339
Query: 457 RY 458
Y
Sbjct: 340 NY 341
>gi|11056032 protocadherin gamma subfamily A, 1 isoform 1 precursor
[Homo sapiens]
Length = 931
Score = 31.6 bits (70), Expect = 2.5
Identities = 32/118 (27%), Positives = 49/118 (41%), Gaps = 14/118 (11%)
Query: 299 TERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEES 358
TE H+ L DI+D+ + + A P N+ GA + V + ++LD
Sbjct: 434 TETHISLLVTDINDNSPVFHQDSYSAYIPENNPR---------GASIFSVRA-HDLDSNE 483
Query: 359 NKKHPFPC--PTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGE 414
N + + T L+ YL I + T VLY L + E L+ MA SG+
Sbjct: 484 NAQITYSLIEDTIQGAPLSAYLSINSD--TGVLYALRSFDYEQFRDMQLKVMARDSGD 539
>gi|14196459 protocadherin gamma subfamily A, 1 isoform 2 precursor
[Homo sapiens]
Length = 823
Score = 31.6 bits (70), Expect = 2.5
Identities = 32/118 (27%), Positives = 49/118 (41%), Gaps = 14/118 (11%)
Query: 299 TERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEES 358
TE H+ L DI+D+ + + A P N+ GA + V + ++LD
Sbjct: 434 TETHISLLVTDINDNSPVFHQDSYSAYIPENNPR---------GASIFSVRA-HDLDSNE 483
Query: 359 NKKHPFPC--PTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGE 414
N + + T L+ YL I + T VLY L + E L+ MA SG+
Sbjct: 484 NAQITYSLIEDTIQGAPLSAYLSINSD--TGVLYALRSFDYEQFRDMQLKVMARDSGD 539
>gi|157676331 hyaluronan binding protein 4 [Homo sapiens]
Length = 413
Score = 31.2 bits (69), Expect = 3.3
Identities = 36/157 (22%), Positives = 58/157 (36%), Gaps = 19/157 (12%)
Query: 177 GNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGV 236
G + +E + K + + +G + G G D ++E P V E
Sbjct: 212 GKREFERYGGNDKIAVRTEDNMGGCGVRTWGSGKDTSDVEPT----APMEEPTVVE---- 263
Query: 237 EATG---EESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNR 293
E+ G EES + EL V + ++ + E L+ KP F+ + P +
Sbjct: 264 ESQGTPEEESPAKVPELEVEEETQVQEMTLDEWKNLQEQTRPKPEFNIRKPESTVPSKAV 323
Query: 294 KLNQGTERHLMHLELDISDSKIRYESGDHVAVYPAND 330
+++ R M K YE HV PAND
Sbjct: 324 VIHKSKYRDDM--------VKDDYEDDSHVFRKPAND 352
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,519,478
Number of Sequences: 37866
Number of extensions: 1146681
Number of successful extensions: 2577
Number of sequences better than 10.0: 24
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2480
Number of HSP's gapped (non-prelim): 39
length of query: 680
length of database: 18,247,518
effective HSP length: 109
effective length of query: 571
effective length of database: 14,120,124
effective search space: 8062590804
effective search space used: 8062590804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.