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Search of human proteins with 4504547
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo
sapiens]
(445 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 907 0.0
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 879 0.0
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 878 0.0
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 226 3e-59
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 224 2e-58
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 220 2e-57
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 220 2e-57
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 220 2e-57
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 220 2e-57
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 220 2e-57
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 219 4e-57
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 215 7e-56
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 214 2e-55
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 213 4e-55
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 204 1e-52
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 196 4e-50
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 195 8e-50
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 195 8e-50
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 195 8e-50
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 195 8e-50
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 195 8e-50
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 195 8e-50
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 191 9e-49
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 189 3e-48
gi|4503383 dopamine receptor D1 [Homo sapiens] 187 2e-47
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 184 2e-46
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 184 2e-46
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 184 2e-46
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 177 2e-44
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 177 2e-44
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 907 bits (2345), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
Sbjct: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60
Query: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120
DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
Sbjct: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120
Query: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180
VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
Sbjct: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180
Query: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
Sbjct: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240
Query: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300
IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
Sbjct: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300
Query: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360
ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
Sbjct: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360
Query: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420
IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
Sbjct: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420
Query: 421 LAERPERPEFVLQNADYCRKKGHDS 445
LAERPERPEFVLQNADYCRKKGHDS
Sbjct: 421 LAERPERPEFVLQNADYCRKKGHDS 445
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 879 bits (2270), Expect = 0.0
Identities = 432/433 (99%), Positives = 433/433 (100%)
Query: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
Sbjct: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60
Query: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120
DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
Sbjct: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120
Query: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180
VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
Sbjct: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180
Query: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
Sbjct: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240
Query: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300
IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
Sbjct: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300
Query: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360
ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
Sbjct: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360
Query: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420
IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
Sbjct: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420
Query: 421 LAERPERPEFVLQ 433
LAERPERPEFVL+
Sbjct: 421 LAERPERPEFVLR 433
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 878 bits (2269), Expect = 0.0
Identities = 432/432 (100%), Positives = 432/432 (100%)
Query: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
Sbjct: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60
Query: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120
DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
Sbjct: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120
Query: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180
VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
Sbjct: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180
Query: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
Sbjct: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240
Query: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300
IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
Sbjct: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300
Query: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360
ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
Sbjct: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360
Query: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420
IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
Sbjct: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420
Query: 421 LAERPERPEFVL 432
LAERPERPEFVL
Sbjct: 421 LAERPERPEFVL 432
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 226 bits (576), Expect = 3e-59
Identities = 124/341 (36%), Positives = 197/341 (57%), Gaps = 26/341 (7%)
Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
+ +G +L L I GN LV++SV + LR P+NY IV+LA+ADL ++ V+PF +
Sbjct: 46 ISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAAL 105
Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
+++G W+ G FC+++ A+DV+CCTASI++LC ISIDRY+G+ L YP +
Sbjct: 106 EVLG-YWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAIL 164
Query: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260
+LSVW+LS I++ PL GW + NDDK C ++++ Y ++S+ +FYIP++V+L MY
Sbjct: 165 ALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYC 224
Query: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHE-RKNISI- 318
++Y A+++ + + + L + + E+ + ++ H R +I++
Sbjct: 225 RVYIVAKRTTKNLEAGVMKEMSNSKELTLR--IHSKNFHEDTLSSTKAKGHNPRSSIAVK 282
Query: 319 ---FKREQKAATTLGIIVGAFTVCWLPFF-------LLSTARPFICGTSCSCIPLWVERT 368
F RE+KAA TLGI+VG F +CWLPFF L ST +P P V +
Sbjct: 283 LFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKP----------PDAVFKV 332
Query: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRK 409
WLGY NS +NP IY +++ + + +L CQ R R+
Sbjct: 333 VFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRR 373
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 224 bits (570), Expect = 2e-58
Identities = 138/419 (32%), Positives = 218/419 (52%), Gaps = 74/419 (17%)
Query: 50 SEVTASPAPTWDAPPDNASGCGE-QINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCF 108
+ T+ PAP N +G + ++Y + +++G+++ + GN VV ++
Sbjct: 10 NNTTSPPAPFETG--GNTTGISDVTVSYQVITSLLLGTLI----FCAVLGNACVVAAIAL 63
Query: 109 VKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTA 168
+ L+ +NYLI SLA+ DL V+V V+P ++ ++ KW G C++FIA+DV+CCT+
Sbjct: 64 ERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN-KWTLGQVTCDLFIALDVLCCTS 122
Query: 169 SIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW--AQNVN 226
SI+ LC I++DRY IT P+ Y ++ + A +I WL+ I++PP+ GW ++ +
Sbjct: 123 SILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRS 182
Query: 227 DDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR-----------KSAAKHKF 275
D C IS+D GYTIYST AFYIP+ +ML +Y +I++AAR K+ A +
Sbjct: 183 DPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRH 242
Query: 276 PGFPRVEP---------------------DSVIALNGIVK-----LQKEVEE-------- 301
P +P + NG V+ EV E
Sbjct: 243 GASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSK 302
Query: 302 -------------CANLSRLLKHER----KNISIFKREQKAATTLGIIVGAFTVCWLPFF 344
CA S K+ER K RE+K TLGII+G F +CWLPFF
Sbjct: 303 EHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFF 362
Query: 345 LLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403
+++ PF C +SC +P + WLGY+NSL+NP IYA+FN+D + ++ +++C++
Sbjct: 363 IVALVLPF-CESSCH-MPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 220 bits (561), Expect = 2e-57
Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%)
Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
+++G IL + L + GN LV++SV + L ++Y IV+LA+ADL + V+PF ++
Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
+++G W FG FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP +
Sbjct: 87 EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145
Query: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260
+L VW LS I++ PLFGW Q D+ +C I+++ GY ++S +FY+P++++L MY
Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205
Query: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319
++Y A++ + K G + DS I + S K H + F
Sbjct: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264
Query: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379
RE+KAA TLGI+VG F +CWLPFFL+ F S V + WLGY NS I
Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321
Query: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402
NP IY +++ + ++++L+ Q
Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 220 bits (561), Expect = 2e-57
Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%)
Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
+++G IL + L + GN LV++SV + L ++Y IV+LA+ADL + V+PF ++
Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
+++G W FG FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP +
Sbjct: 87 EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145
Query: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260
+L VW LS I++ PLFGW Q D+ +C I+++ GY ++S +FY+P++++L MY
Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205
Query: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319
++Y A++ + K G + DS I + S K H + F
Sbjct: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264
Query: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379
RE+KAA TLGI+VG F +CWLPFFL+ F S V + WLGY NS I
Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321
Query: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402
NP IY +++ + ++++L+ Q
Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 220 bits (561), Expect = 2e-57
Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%)
Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
+++G IL + L + GN LV++SV + L ++Y IV+LA+ADL + V+PF ++
Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
+++G W FG FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP +
Sbjct: 87 EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145
Query: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260
+L VW LS I++ PLFGW Q D+ +C I+++ GY ++S +FY+P++++L MY
Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205
Query: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319
++Y A++ + K G + DS I + S K H + F
Sbjct: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264
Query: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379
RE+KAA TLGI+VG F +CWLPFFL+ F S V + WLGY NS I
Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321
Query: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402
NP IY +++ + ++++L+ Q
Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 220 bits (561), Expect = 2e-57
Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%)
Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
+++G IL + L + GN LV++SV + L ++Y IV+LA+ADL + V+PF ++
Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
+++G W FG FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP +
Sbjct: 87 EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145
Query: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260
+L VW LS I++ PLFGW Q D+ +C I+++ GY ++S +FY+P++++L MY
Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205
Query: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319
++Y A++ + K G + DS I + S K H + F
Sbjct: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264
Query: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379
RE+KAA TLGI+VG F +CWLPFFL+ F S V + WLGY NS I
Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321
Query: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402
NP IY +++ + ++++L+ Q
Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 220 bits (560), Expect = 2e-57
Identities = 129/349 (36%), Positives = 191/349 (54%), Gaps = 33/349 (9%)
Query: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140
K+++ L+ + L+T N LV+ ++ +KL P+NYLI SLA+ D VAV VMPF S+
Sbjct: 23 KILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPF-SI 81
Query: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200
++ WI G C++++++D+ CCT SI+ L I++DRY IT + Y ++ K
Sbjct: 82 VYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAG 141
Query: 201 KMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQD-FGYTIYSTAVAFYIPMSVMLFMY 259
MI VW++S I++PPLF Q + D C+I D TIYST AFYIP++++L +Y
Sbjct: 142 IMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY 201
Query: 260 YQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLL---------- 309
Y+IY+AA+ K + + E + + L K K V L + L
Sbjct: 202 YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261
Query: 310 -----------KHE----RKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFIC 354
KHE R+ IS RE+KAATTLG+I+GAF +CWLPFF+ + +
Sbjct: 262 HSTVRSLRSEFKHEKSWRRQKIS-GTRERKAATTLGLILGAFVICWLPFFV----KELVV 316
Query: 355 GTSCSC-IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402
C I + WLGY NSLINP IY FN D + ++ L++C+
Sbjct: 317 NVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 219 bits (558), Expect = 4e-57
Identities = 134/344 (38%), Positives = 188/344 (54%), Gaps = 35/344 (10%)
Query: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140
K+ + +L++ITL T+ N V+ ++ +KL P+NYLI SLA DL V++ VMP +S+
Sbjct: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMP-ISI 96
Query: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200
I W FG C+++++ D+ CCTASI+ LCVI++DRY IT L Y R+ A
Sbjct: 97 AYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAA 156
Query: 201 KMILSVWLLSASITLPPLFGWAQNVNDDKV--CLI-SQDFGYTIYSTAVAFYIPMSVMLF 257
MI VW +S I++PPLF W Q +++ CL+ + YTIYST AFYIP +++
Sbjct: 157 TMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLII 215
Query: 258 MYYQIYKAAR------------KSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANL 305
+Y +IY+AAR + H G S+ +LN L + A
Sbjct: 216 LYGRIYRAARNRILNPPSLYGKRFTTAHLITG---SAGSSLCSLNS--SLHEGHSHSAGS 270
Query: 306 SRLLKH----------ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICG 355
H ERK IS RE+KA LGII+GAF +CWLPFF++S P IC
Sbjct: 271 PLFFNHVKIKLADSALERKRISA-ARERKATKILGIILGAFIICWLPFFVVSLVLP-ICR 328
Query: 356 TSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
SC P + F WLGY NSLINP IY FN + R ++ ++
Sbjct: 329 DSCWIHPALFD-FFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 215 bits (547), Expect = 7e-56
Identities = 141/387 (36%), Positives = 206/387 (53%), Gaps = 38/387 (9%)
Query: 39 PVAGS--WAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTI 96
P AGS W P + S AP+ + +A Q + KV++ +L LITL T
Sbjct: 12 PPAGSETWVP----QANLSSAPSQNC---SAKDYIYQDSISLPWKVLLVMLLALITLATT 64
Query: 97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCN 156
N V+ +V +KL P+NYLI SLA+ DL V++ VMP +S + G+W G C+
Sbjct: 65 LSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMP-ISTMYTVTGRWTLGQVVCD 123
Query: 157 VFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP 216
+++ D+ CCTASI+ LCVI++DRY IT + Y ++ K A MI VW+ S SI+LP
Sbjct: 124 FWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLP 183
Query: 217 PLFGWAQNVNDDKV--CLISQD-FGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH 273
P F W Q +++V C+++ D YT+YST AFY P +++ +Y +IY AR K
Sbjct: 184 PFF-WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQ 242
Query: 274 ------KFPGFPRVEPDSVIALNGIVKLQKEVEEC--------------ANLSRLLKHER 313
K ++ DS + + + + V + +S L ++
Sbjct: 243 TPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKK 302
Query: 314 KNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373
K ++ RE+KA TLGII+GAF VCWLPFF++S P IC +C L + F WLG
Sbjct: 303 KLMA--ARERKATKTLGIILGAFIVCWLPFFIISLVMP-ICKDAC-WFHLAIFDFFTWLG 358
Query: 374 YANSLINPFIYAFFNRDLRTTYRSLLQ 400
Y NSLINP IY N D + + L++
Sbjct: 359 YLNSLINPIIYTMSNEDFKQAFHKLIR 385
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 214 bits (544), Expect = 2e-55
Identities = 135/352 (38%), Positives = 192/352 (54%), Gaps = 39/352 (11%)
Query: 80 EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVS 139
EK++I L +IT LT N V++++ KKL QP+NYLI SLA+ DL VAV VMP +S
Sbjct: 21 EKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMP-LS 79
Query: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
+ ++ +W G+F C V++++D+ CCT SI+ LCVI++DRY IT + Y ++ K
Sbjct: 80 IIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRA 139
Query: 200 AKMILSVWLLSASITLPPLFGWAQNVN---DDKVCLISQDFG-YTIYSTAVAFYIPMSVM 255
A MIL+VW +S I++PPLF W + C I D YTIYST AFYIP++++
Sbjct: 140 ALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLI 198
Query: 256 LFMYYQIYKAARKSAAKHKFPGFPR-VEPDSVIALNGIVKLQKEVEECAN---------- 304
L +YY+IY AA+ K G R + S + N + C +
Sbjct: 199 LILYYRIYHAAKSLYQKR---GSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTE 255
Query: 305 ------------LSRLLKH--ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTAR 350
L H ER+ IS RE+KAA LG+I+GAF + WLPFF+ +
Sbjct: 256 FEKFHASIRIPPFDNDLDHPGERQQIS-STRERKAARILGLILGAFILSWLPFFI----K 310
Query: 351 PFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402
I G S + V WLGY NSLINP +Y FN D + ++ L++C+
Sbjct: 311 ELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCR 362
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 213 bits (541), Expect = 4e-55
Identities = 134/396 (33%), Positives = 213/396 (53%), Gaps = 17/396 (4%)
Query: 22 PEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK 81
P VG G+P + GG AGS + S A A+ G ++ +
Sbjct: 41 PAVG-GVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVS---AQG 96
Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
V +G L L+ +AGN LV++SV + L+ +NY IV+LA+ADL ++ V+PF +
Sbjct: 97 VGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATM 156
Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
+++G W FG FC+V+ A+DV+CCTASI++LC IS+DRY+G+ L YP + A
Sbjct: 157 EVLGF-WAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAA 215
Query: 202 MILSVWLLSASITLPPLFGWAQNVN-DDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260
++ +W+++ +++ PL GW + V D++ C I+++ GY ++S+ +FY+PM+V++ MY
Sbjct: 216 ILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYC 275
Query: 261 QIYKAARKSAAKHKFPGFPRVEPD-SVIALNGIVKLQKEVEECANLSRLLKHE--RKNIS 317
++Y AR S + G R S + L + + A+ R K R ++S
Sbjct: 276 RVYVVAR-STTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLS 334
Query: 318 I----FKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373
+ F RE+KAA TL I+VG F +CW PFF + S V + WLG
Sbjct: 335 VRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS---EGVFKVIFWLG 391
Query: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRK 409
Y NS +NP IY +R+ + + LL+CQ R R+
Sbjct: 392 YFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRR 427
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 204 bits (519), Expect = 1e-52
Identities = 120/335 (35%), Positives = 189/335 (56%), Gaps = 31/335 (9%)
Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
V+I ++L + T A N LV+ ++ V+ + + L+ S+A++D+ VA VMP V
Sbjct: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
+L G +W G C ++IA DV+CCTASI + I++DRY ITR + Y +R KC++
Sbjct: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTR-KCVSN 159
Query: 202 -MILSVWLLSASITLPP-LFGWAQNVND-DKVCLISQDFGYTIYSTAVAFYIPMSVMLFM 258
MI W LSA I+L P LFGW + ++ + C +S++ Y ++ST AFY+P+ V+LF+
Sbjct: 160 VMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFV 219
Query: 259 YYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISI 318
Y++IYKAA+ K +SV ++ V EV++ A +++ R
Sbjct: 220 YWKIYKAAKFRVGSRK--------TNSVSPISEAV----EVKDSAKQPQMVFTVRHATVT 267
Query: 319 F---------KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC-IPLWVERT 368
F ++EQ+AA +GI++G F +CW+PFFL P CSC IP +
Sbjct: 268 FQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPL-----CSCDIPAIWKSI 322
Query: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403
FLWLGY+NS NP IY FN++ + +++ Q+
Sbjct: 323 FLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH 357
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 196 bits (498), Expect = 4e-50
Identities = 124/352 (35%), Positives = 185/352 (52%), Gaps = 27/352 (7%)
Query: 84 IGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDL 143
+G ++ LI LL +AGN LV++++ +L+ +N I+SLA ADL + + V+PF T +
Sbjct: 61 MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPF-GATIV 119
Query: 144 IGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMI 203
+ G+W +G FFC ++ ++DV+C TASI TLCVI++DRYL IT P Y ++
Sbjct: 120 VWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV 179
Query: 204 LSVWLLSASIT-LPPLFGW--------AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSV 254
+VW +SA ++ LP L W + ND K C + Y I S+ V+FY+P+ +
Sbjct: 180 CTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCI 239
Query: 255 MLFMYYQIYKAARKSAAK-----HKFPGFPRVEPD---SVIALNGIVKLQKEVEECANLS 306
M F+Y ++++ A+K K +F G P P S + A +
Sbjct: 240 MAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATA 299
Query: 307 RLLK----HERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIP 362
L R + + REQKA TLGII+G FT+CWLPFFL + + F +P
Sbjct: 300 PLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAF----HRELVP 355
Query: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAG 414
+ F WLGYANS NP IY + D R ++ LL C R R+ + G
Sbjct: 356 DRLFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARRRHATHG 406
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 195 bits (495), Expect = 8e-50
Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%)
Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134
+G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V
Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73
Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193
MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y +
Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132
Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239
+A M+ W++ I+ LP + GW N N + C+ + Y
Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192
Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299
I + VAFYIP +M+ YY+IY A++ A H+ R S
Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237
Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359
SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T
Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288
Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408
+P V FLWLGY NS +NPF+YAF N+ R + +L C R
Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 195 bits (495), Expect = 8e-50
Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%)
Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134
+G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V
Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73
Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193
MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y +
Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132
Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239
+A M+ W++ I+ LP + GW N N + C+ + Y
Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192
Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299
I + VAFYIP +M+ YY+IY A++ A H+ R S
Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237
Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359
SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T
Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288
Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408
+P V FLWLGY NS +NPF+YAF N+ R + +L C R
Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 195 bits (495), Expect = 8e-50
Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%)
Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134
+G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V
Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73
Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193
MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y +
Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132
Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239
+A M+ W++ I+ LP + GW N N + C+ + Y
Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192
Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299
I + VAFYIP +M+ YY+IY A++ A H+ R S
Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237
Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359
SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T
Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288
Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408
+P V FLWLGY NS +NPF+YAF N+ R + +L C R
Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 195 bits (495), Expect = 8e-50
Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%)
Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134
+G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V
Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73
Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193
MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y +
Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132
Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239
+A M+ W++ I+ LP + GW N N + C+ + Y
Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192
Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299
I + VAFYIP +M+ YY+IY A++ A H+ R S
Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237
Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359
SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T
Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288
Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408
+P V FLWLGY NS +NPF+YAF N+ R + +L C R
Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 195 bits (495), Expect = 8e-50
Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%)
Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134
+G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V
Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73
Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193
MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y +
Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132
Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239
+A M+ W++ I+ LP + GW N N + C+ + Y
Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192
Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299
I + VAFYIP +M+ YY+IY A++ A H+ R S
Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237
Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359
SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T
Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288
Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408
+P V FLWLGY NS +NPF+YAF N+ R + +L C R
Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 195 bits (495), Expect = 8e-50
Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%)
Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134
+G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V
Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73
Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193
MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y +
Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132
Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239
+A M+ W++ I+ LP + GW N N + C+ + Y
Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192
Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299
I + VAFYIP +M+ YY+IY A++ A H+ R S
Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237
Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359
SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T
Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288
Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408
+P V FLWLGY NS +NPF+YAF N+ R + +L C R
Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 191 bits (486), Expect = 9e-49
Identities = 122/339 (35%), Positives = 179/339 (52%), Gaps = 38/339 (11%)
Query: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150
+ L + GN LV ++V + L+ +NYL+VSLA+ADL VA VMP+V ++ GG W F
Sbjct: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
Query: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207
C+VF+ +DVM CTASI+ LC ISIDRY + P+ Y + + + +A MI +VW
Sbjct: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
Query: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267
+L+ +++ P LFG+ D VC IS + IYS+ V+FY+P V + +Y +IY +
Sbjct: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216
Query: 268 KSAAKHKF-----------PGFPR--VEPDSVIALNGIVKLQKEVEECANLS-------- 306
+ K PGFP+ + PD ++L++ C + +
Sbjct: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDP-----AHLELKRYYSICQDTALGGPGFQE 271
Query: 307 ---RLLKHERKNISIFK-REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIP 362
L + E+ S+ RE+KA + I++GAF VCWLPFFL C T C P
Sbjct: 272 RGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTH-CQT-CHVSP 329
Query: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
T WLGY NS +NP IY FN + R + +L C
Sbjct: 330 ELYSAT-TWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 189 bits (481), Expect = 3e-48
Identities = 129/364 (35%), Positives = 184/364 (50%), Gaps = 58/364 (15%)
Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134
+G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V
Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73
Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGI-TRPLTYPVR 193
MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y +
Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132
Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGW----------------------------AQN 224
+A M+ W++ I+ LP + GW QN
Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDFHAIEKRKFNQN 192
Query: 225 VNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPD 284
N C+ + Y I + VAFYIP +M+ YY+IY A++ A H+ R
Sbjct: 193 SN-STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGAS 249
Query: 285 SVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFF 344
S SR ++ + + E KAA TL II+G F +CW PFF
Sbjct: 250 SE-------------------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFF 290
Query: 345 LLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYR 404
+ + PFI T +P V FLWLGY NS +NPF+YAF N+ R + +L C
Sbjct: 291 VTNIVDPFIDYT----VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDE 346
Query: 405 NINR 408
R
Sbjct: 347 RYRR 350
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 187 bits (474), Expect = 2e-47
Identities = 124/343 (36%), Positives = 180/343 (52%), Gaps = 40/343 (11%)
Query: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQP-SNYLIVSLALADLSVAVAVMPFVS 139
+++ L+L+ L T+ GN LV +V + LR +N+ ++SLA++DL VAV VMP+ +
Sbjct: 23 RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKA 82
Query: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
V + I G W FG F CN+++A D+MC TASI+ LCVIS+DRY I+ P Y + K
Sbjct: 83 VAE-IAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAA 140
Query: 200 AKMILSVWLLSASIT-LPPLFGW----------------AQNVNDDKVCLISQDFGYTIY 242
+I W LS I+ +P W A+ +++ C S Y I
Sbjct: 141 FILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDN---CDSSLSRTYAIS 197
Query: 243 STAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALN-GIVKLQKEVEE 301
S+ ++FYIP+++M+ Y +IY+ A+K + +E +V A N + E
Sbjct: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRR-----IAALERAAVHAKNCQTTTGNGKPVE 252
Query: 302 CANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICG---TSC 358
C+ K FKRE K TL +I+G F CWLPFF+L+ PF CG T
Sbjct: 253 CSQPESSFKMS------FKRETKVLKTLSVIMGVFVCCWLPFFILNCILPF-CGSGETQP 305
Query: 359 SCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
CI F+W G+ANS +NP IYA FN D R + +LL C
Sbjct: 306 FCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLLGC 347
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 184 bits (466), Expect = 2e-46
Identities = 129/367 (35%), Positives = 181/367 (49%), Gaps = 61/367 (16%)
Query: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150
+ L + GN LV ++V + L+ +NYL+VSLA+ADL VA VMP+V ++ GG W F
Sbjct: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
Query: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207
C+VF+ +DVM CTASI+ LC ISIDRY + P+ Y + + + +A MI +VW
Sbjct: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
Query: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267
+L+ +++ P LFG+ D VC IS + IYS+ V+FY+P V + +Y +IY +
Sbjct: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216
Query: 268 KSAAKHKF-----------PGFPR--VEPDSV-------------IALNG---------- 291
+ K PGFP+ + PD AL G
Sbjct: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGEL 276
Query: 292 --------------IVKLQKEVEECAN--LSRLLK-HERKNISIFKREQKAATTLGIIVG 334
KL EV + +N LS LK + + RE+KA + I++G
Sbjct: 277 KREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLG 336
Query: 335 AFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394
AF VCWLPFFL C T C P T WLGY NS +NP IY FN + R
Sbjct: 337 AFIVCWLPFFLTHVLNTH-CQT-CHVSPELYSAT-TWLGYVNSALNPVIYTTFNIEFRKA 393
Query: 395 YRSLLQC 401
+ +L C
Sbjct: 394 FLKILSC 400
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 184 bits (466), Expect = 2e-46
Identities = 110/334 (32%), Positives = 167/334 (50%), Gaps = 47/334 (14%)
Query: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140
K+ I +L ++ L+T+AGN +V ++V ++LR +N IVSLA+ DL + + V+PF ++
Sbjct: 18 KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAI 77
Query: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200
L KW FG FCN++ ++DVM CTASI+ L +IS+DRY + PL YPV +A
Sbjct: 78 YQL-SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVA 136
Query: 201 KMILSVWLLSASITLPPL-FGWAQNVNDDK------VCLISQDFGYTIYSTAVAFYIPMS 253
++ +W++S +++ + GW K C + + Y + V FY+P+
Sbjct: 137 ISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLL 196
Query: 254 VMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHER 313
+M YY+I+K AR A + + H
Sbjct: 197 IMCITYYRIFKVARDQAKR------------------------------------INHIS 220
Query: 314 KNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373
+ RE KA TL ++GAF +CW P+F TA + I +E LWLG
Sbjct: 221 SWKAATIREHKATVTLAAVMGAFIICWFPYF---TAFVYRGLRGDDAINEVLEAIVLWLG 277
Query: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNIN 407
YANS +NP +YA NRD RT Y+ L C+ N N
Sbjct: 278 YANSALNPILYAALNRDFRTGYQQLFCCRLANRN 311
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 184 bits (466), Expect = 2e-46
Identities = 110/334 (32%), Positives = 167/334 (50%), Gaps = 47/334 (14%)
Query: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140
K+ I +L ++ L+T+AGN +V ++V ++LR +N IVSLA+ DL + + V+PF ++
Sbjct: 18 KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAI 77
Query: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200
L KW FG FCN++ ++DVM CTASI+ L +IS+DRY + PL YPV +A
Sbjct: 78 YQL-SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVA 136
Query: 201 KMILSVWLLSASITLPPL-FGWAQNVNDDK------VCLISQDFGYTIYSTAVAFYIPMS 253
++ +W++S +++ + GW K C + + Y + V FY+P+
Sbjct: 137 ISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLL 196
Query: 254 VMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHER 313
+M YY+I+K AR A + + H
Sbjct: 197 IMCITYYRIFKVARDQAKR------------------------------------INHIS 220
Query: 314 KNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373
+ RE KA TL ++GAF +CW P+F TA + I +E LWLG
Sbjct: 221 SWKAATIREHKATVTLAAVMGAFIICWFPYF---TAFVYRGLRGDDAINEVLEAIVLWLG 277
Query: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNIN 407
YANS +NP +YA NRD RT Y+ L C+ N N
Sbjct: 278 YANSALNPILYAALNRDFRTGYQQLFCCRLANRN 311
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 177 bits (449), Expect = 2e-44
Identities = 107/333 (32%), Positives = 172/333 (51%), Gaps = 21/333 (6%)
Query: 80 EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVS 139
E + G++L L L T+ GN LV++++ + +L+ +N + SLA ADL + + V+P +
Sbjct: 36 EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVP-PA 94
Query: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
T + G W G C ++ ++DV+C TASI TLC +++DRYL +T PL Y +C
Sbjct: 95 ATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCA 154
Query: 200 AKMILSVWLLSASITLPPLFGWAQNVNDD----------KVCLISQDFGYTIYSTAVAFY 249
++ VW++SA+++ P+ V D + C + + Y + S++V+FY
Sbjct: 155 RTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFY 214
Query: 250 IPMSVMLFMYYQIYKAARKS--AAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSR 307
+P+ VMLF+Y +++ A + + + FP P+ V CA
Sbjct: 215 LPLLVMLFVYARVFVVATRQLRLLRGELGRFP---PEESPPAPSRSLAPAPVGTCAPPEG 271
Query: 308 LLKHERKNISIFK-REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVE 366
+ R+ + RE +A TLG+I+G FT+CWLPFFL + R S +P
Sbjct: 272 VPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRAL---GGPSLVPGPAF 328
Query: 367 RTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
WLGYANS NP IY + D R+ +R LL
Sbjct: 329 LALNWLGYANSAFNPLIYC-RSPDFRSAFRRLL 360
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 177 bits (449), Expect = 2e-44
Identities = 122/387 (31%), Positives = 181/387 (46%), Gaps = 33/387 (8%)
Query: 53 TASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKL 112
TA+ P W A P +A G + + L ++ LT A N L++ +C L
Sbjct: 8 TANSTPAWGAGPPSAPGGSGWV----------AAALCVVIALTAAANSLLIALICTQPAL 57
Query: 113 RQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMT 172
R SN+ +VSL +DL V + VMP ++ + + G+W+ C ++ A DVMCC+ASI+
Sbjct: 58 RNTSNFFLVSLFTSDLMVGLVVMP-PAMLNALYGRWVLARGLCLLWTAFDVMCCSASILN 116
Query: 173 LCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASIT-LPPLFGWAQ----NVND 227
LC+IS+DRYL I PL Y +R ++L W L+A + LP L GW +
Sbjct: 117 LCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPV 176
Query: 228 DKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVI 287
C + + + ++ + F++P + F Y +I AARK A +
Sbjct: 177 PGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAV--QVASLTTGMASQAS 234
Query: 288 ALNGIVKLQKEVEECANLSRL-LKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLL 346
+ + + E A+ RL KH RK + KA+ TLGI++G F V WLPFF+
Sbjct: 235 ETLQVPRTPRPGVESADSRRLATKHSRKAL-------KASLTLGILLGMFFVTWLPFFVA 287
Query: 347 STARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNI 406
+ I C CI + WLGY NS +NP IY F RD + L C
Sbjct: 288 N-----IVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPR 342
Query: 407 NRKLSAAGMHEALKLAERPERPEFVLQ 433
R+ S A +L+ + RP LQ
Sbjct: 343 ERQASLAS--PSLRTSHSGPRPGLSLQ 367
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.139 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,752,964
Number of Sequences: 37866
Number of extensions: 720666
Number of successful extensions: 4501
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 518
Number of HSP's successfully gapped in prelim test: 215
Number of HSP's that attempted gapping in prelim test: 2567
Number of HSP's gapped (non-prelim): 1368
length of query: 445
length of database: 18,247,518
effective HSP length: 105
effective length of query: 340
effective length of database: 14,271,588
effective search space: 4852339920
effective search space used: 4852339920
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.