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Search of human proteins with 4504535
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
(377 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 753 0.0
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 472 e-133
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 323 2e-88
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 322 3e-88
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 288 7e-78
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 219 3e-57
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 219 3e-57
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 219 3e-57
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 212 5e-55
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 209 3e-54
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 209 3e-54
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 209 3e-54
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 209 3e-54
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 207 1e-53
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 195 5e-50
gi|4503383 dopamine receptor D1 [Homo sapiens] 195 5e-50
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 194 1e-49
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 192 3e-49
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 191 7e-49
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 189 5e-48
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 183 3e-46
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 177 1e-44
gi|4503391 dopamine receptor D5 [Homo sapiens] 176 2e-44
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 175 5e-44
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 175 5e-44
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 174 2e-43
gi|21264324 trace amine associated receptor 1 [Homo sapiens] 172 6e-43
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 167 2e-41
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 162 5e-40
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 161 1e-39
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 753 bits (1944), Expect = 0.0
Identities = 377/377 (100%), Positives = 377/377 (100%)
Query: 1 MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL 60
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL
Sbjct: 1 MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL 60
Query: 61 TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT 120
TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT
Sbjct: 61 TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT 120
Query: 121 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK 180
CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK
Sbjct: 121 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK 180
Query: 181 AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT 240
AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT
Sbjct: 181 AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT 240
Query: 241 TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT 300
TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT
Sbjct: 241 TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT 300
Query: 301 KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN 360
KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN
Sbjct: 301 KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN 360
Query: 361 EEFRQAFQKIVPFRKAS 377
EEFRQAFQKIVPFRKAS
Sbjct: 361 EEFRQAFQKIVPFRKAS 377
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 472 bits (1215), Expect = e-133
Identities = 230/343 (67%), Positives = 280/343 (81%), Gaps = 4/343 (1%)
Query: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIA 97
K+ L ++L++ITLAT LSNAFV+ T+ TRKLHTPANYLI SLA TDLLVSILVMPIS
Sbjct: 49 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTM 108
Query: 98 YTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAT 157
YT+T W GQ++CD WLSSDITCCTASILHLCVIALDRYWAITDA+EYS +RT AA
Sbjct: 109 YTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAV 168
Query: 158 MIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217
MIA+VW SI IS+PP FWRQAKA+EE+S+C+VNT I YT+YST GAFY P++LLI LY
Sbjct: 169 MIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALY 228
Query: 218 GRIYRAARNRIL-NPPSLYGKRFTTAHLITGSAG--SSLCSLNSSLHEGHSHSAGSPLFF 274
GRIY AR+RIL P+ GKR T A LIT S G SS+ S+NS + + S S GSP++
Sbjct: 229 GRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSES-GSPVYV 287
Query: 275 NHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIH 334
N VK++++D+ LE+K++ AARERKATK LGIILGAFI+CWLPFF++SLV+PIC+D+CW H
Sbjct: 288 NQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFH 347
Query: 335 PALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS 377
A+FDFFTWLGYLNSLINPIIYT+ NE+F+QAF K++ F+ S
Sbjct: 348 LAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS 390
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 323 bits (828), Expect = 2e-88
Identities = 178/366 (48%), Positives = 233/366 (63%), Gaps = 23/366 (6%)
Query: 23 TETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLAT 82
TE S A P+T+ K+ + + L VIT T L N V+ I T+KLH PANYLI SLA
Sbjct: 8 TEASMAIRPKTITE-KMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAV 66
Query: 83 TDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITD 142
TDLLV++LVMP+SI Y + W G LC++WLS D+TCCT SILHLCVIALDRYWAIT+
Sbjct: 67 TDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITN 126
Query: 143 ALEYSKRRTAGHAATMIAIVWAISICISIPPLFWR-QAKAQEEMSDCLVNTSQISYTIYS 201
A+EY+++RTA AA MI VW ISI IS+PPLFWR + S C + + YTIYS
Sbjct: 127 AIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYS 186
Query: 202 TCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGS----SLCSLN 257
T GAFYIP L++ILY RIY AA+ SLY KR ++ HL S S + C L
Sbjct: 187 TLGAFYIPLTLILILYYRIYHAAK-------SLYQKRGSSRHLSNRSTDSQNSFASCKLT 239
Query: 258 SSLHEGHSHSAGSPLFFN--HVKIKL------ADSALERKRISAARERKATKILGIILGA 309
+ ++ F H I++ D ER++IS+ RERKA +ILG+ILGA
Sbjct: 240 QTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGA 299
Query: 310 FIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQK 369
FI+ WLPFF+ L++ + + + DF TWLGY+NSLINP++YT FNE+F+ AF+K
Sbjct: 300 FILSWLPFFIKELIVGL--SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKK 357
Query: 370 IVPFRK 375
++ R+
Sbjct: 358 LIRCRE 363
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 322 bits (825), Expect = 3e-88
Identities = 174/345 (50%), Positives = 224/345 (64%), Gaps = 10/345 (2%)
Query: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIA 97
KI +++ LS + L T N+ V+ I++TRKLH PANYLI SLA TD LV++LVMP SI
Sbjct: 23 KILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIV 82
Query: 98 YTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAT 157
Y + +W GQ++CDIWLS DITCCT SILHL IALDRY AITDA+EY+++RT HA
Sbjct: 83 YIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGI 142
Query: 158 MIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217
MI IVW IS+ IS+PPLFWR + +C++ I TIYST GAFYIP L++ILY
Sbjct: 143 MITIVWIISVFISMPPLFWRHQGTSRD-DECIIKHDHIVSTIYSTFGAFYIPLALILILY 201
Query: 218 GRIYRAARNRI-LNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFN- 275
+IYRAA+ S K ++ S S S+++S S S S F
Sbjct: 202 YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261
Query: 276 HVKIKLADSALE------RKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRD 329
H ++ S + R++IS RERKA LG+ILGAF+ICWLPFFV LV+ +C D
Sbjct: 262 HSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVC-D 320
Query: 330 SCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFR 374
C I + +F WLGYLNSLINP+IYT+FNE+F++AFQK+V R
Sbjct: 321 KCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 288 bits (736), Expect = 7e-78
Identities = 156/382 (40%), Positives = 220/382 (57%), Gaps = 50/382 (13%)
Query: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIA 97
++ +++L + VL NA V+ I L R L ANYLIGSLA TDL+VS+LV+P++
Sbjct: 36 QVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAAL 95
Query: 98 YTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAT 157
Y + + W GQ+ CD++++ D+ CCT+SILHLC IALDRYWAITD ++Y +RT AA
Sbjct: 96 YQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAA 155
Query: 158 MIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIIL 216
+I++ W I ISIPP+ WR + + + C ++ YTIYST GAFYIP +L+++L
Sbjct: 156 LISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDH-GYTIYSTFGAFYIPLLLMLVL 214
Query: 217 YGRIYRAARNRILN----------------PPSLYGKRFTTAHL--------ITGSAGSS 252
YGRI+RAAR RI P+ K+ + AG +
Sbjct: 215 YGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGA 274
Query: 253 LCSLNSSLHEGHS---------HSAGS-----PLFFNHVKIKLADSALERK--------- 289
LC+ N ++ +G H G+ PL A ++ ERK
Sbjct: 275 LCA-NGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKR 333
Query: 290 RISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNS 349
+++ ARERK K LGII+G FI+CWLPFF+V+LVLP C SC + L WLGY NS
Sbjct: 334 KMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNS 393
Query: 350 LINPIIYTVFNEEFRQAFQKIV 371
L+NP+IY FN++F+ AF+KI+
Sbjct: 394 LLNPVIYAYFNKDFQNAFKKII 415
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 219 bits (558), Expect = 3e-57
Identities = 134/344 (38%), Positives = 188/344 (54%), Gaps = 35/344 (10%)
Query: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMP-ISI 96
K+ + +L++ITL T+ N V+ ++ +KL P+NYLI SLA DL V++ VMP +S+
Sbjct: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140
Query: 97 AYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAA 156
I W FG C+++++ D+ CCTASI+ LCVI++DRY IT L Y R+ A
Sbjct: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200
Query: 157 TMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLII 215
MI VW +S I++PPLF W Q +++ CL+ + YTIYST AFYIP +++
Sbjct: 201 KMILSVWLLSASITLPPLFGWAQNVNDDKV--CLI-SQDFGYTIYSTAVAFYIPMSVMLF 257
Query: 216 LYGRIYRAARNRILNPPSLYGKRFTTAHLITG---SAGSSLCSLNS--SLHEGHSHSAGS 270
+Y +IY+AAR + H G S+ +LN L + A
Sbjct: 258 MYYQIYKAAR------------KSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANL 305
Query: 271 PLFFNHVKIKLADSALERKRISA-ARERKATKILGIILGAFIICWLPFFVVSLVLP-ICR 328
H ERK IS RE+KA LGII+GAF +CWLPFF++S P IC
Sbjct: 306 SRLLKH----------ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICG 355
Query: 329 DSCWIHPALFD-FFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
SC P + F WLGY NSLINP IY FN + R ++ ++
Sbjct: 356 TSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 219 bits (558), Expect = 3e-57
Identities = 134/344 (38%), Positives = 188/344 (54%), Gaps = 35/344 (10%)
Query: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMP-ISI 96
K+ + +L++ITL T+ N V+ ++ +KL P+NYLI SLA DL V++ VMP +S+
Sbjct: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140
Query: 97 AYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAA 156
I W FG C+++++ D+ CCTASI+ LCVI++DRY IT L Y R+ A
Sbjct: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200
Query: 157 TMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLII 215
MI VW +S I++PPLF W Q +++ CL+ + YTIYST AFYIP +++
Sbjct: 201 KMILSVWLLSASITLPPLFGWAQNVNDDKV--CLI-SQDFGYTIYSTAVAFYIPMSVMLF 257
Query: 216 LYGRIYRAARNRILNPPSLYGKRFTTAHLITG---SAGSSLCSLNS--SLHEGHSHSAGS 270
+Y +IY+AAR + H G S+ +LN L + A
Sbjct: 258 MYYQIYKAAR------------KSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANL 305
Query: 271 PLFFNHVKIKLADSALERKRISA-ARERKATKILGIILGAFIICWLPFFVVSLVLP-ICR 328
H ERK IS RE+KA LGII+GAF +CWLPFF++S P IC
Sbjct: 306 SRLLKH----------ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICG 355
Query: 329 DSCWIHPALFD-FFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
SC P + F WLGY NSLINP IY FN + R ++ ++
Sbjct: 356 TSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 219 bits (558), Expect = 3e-57
Identities = 134/344 (38%), Positives = 188/344 (54%), Gaps = 35/344 (10%)
Query: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMP-ISI 96
K+ + +L++ITL T+ N V+ ++ +KL P+NYLI SLA DL V++ VMP +S+
Sbjct: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140
Query: 97 AYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAA 156
I W FG C+++++ D+ CCTASI+ LCVI++DRY IT L Y R+ A
Sbjct: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200
Query: 157 TMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLII 215
MI VW +S I++PPLF W Q +++ CL+ + YTIYST AFYIP +++
Sbjct: 201 KMILSVWLLSASITLPPLFGWAQNVNDDKV--CLI-SQDFGYTIYSTAVAFYIPMSVMLF 257
Query: 216 LYGRIYRAARNRILNPPSLYGKRFTTAHLITG---SAGSSLCSLNS--SLHEGHSHSAGS 270
+Y +IY+AAR + H G S+ +LN L + A
Sbjct: 258 MYYQIYKAAR------------KSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANL 305
Query: 271 PLFFNHVKIKLADSALERKRISA-ARERKATKILGIILGAFIICWLPFFVVSLVLP-ICR 328
H ERK IS RE+KA LGII+GAF +CWLPFF++S P IC
Sbjct: 306 SRLLKH----------ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICG 355
Query: 329 DSCWIHPALFD-FFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
SC P + F WLGY NSLINP IY FN + R ++ ++
Sbjct: 356 TSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 212 bits (539), Expect = 5e-55
Identities = 116/336 (34%), Positives = 185/336 (55%), Gaps = 22/336 (6%)
Query: 34 LQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMP 93
L + + +L + AT N VL TIL R H + L+ S+A +D+LV+ LVMP
Sbjct: 36 LSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMP 95
Query: 94 ISIAYTIT-HTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTA 152
+S+ + ++ W G+ LC +W++ D+ CCTASI ++ IALDRYW+IT +EY+ R
Sbjct: 96 LSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRK 155
Query: 153 GHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVL 212
+ MIA+ WA+S IS+ PL + + E S+ + + SY ++ST GAFY+P +
Sbjct: 156 CVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCV 215
Query: 213 LIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPL 272
++ +Y +IY+AA+ R+ G R T +S+ ++ ++ SA P
Sbjct: 216 VLFVYWKIYKAAKFRV-------GSRKT----------NSVSPISEAVEV--KDSAKQPQ 256
Query: 273 FFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCW 332
V+ E +E++A ++GI++G F++CW+PFF+ L+ P+C SC
Sbjct: 257 MVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLC--SCD 314
Query: 333 IHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQ 368
I F WLGY NS NP+IYT FN+ + AF+
Sbjct: 315 IPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 209 bits (532), Expect = 3e-54
Identities = 125/356 (35%), Positives = 196/356 (55%), Gaps = 26/356 (7%)
Query: 21 NATETSEAWDPRTLQALK--ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIG 78
NA+++S P + I L V+L + L VL N V+ ++ R LH+ +Y I
Sbjct: 7 NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
Query: 79 SLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYW 138
+LA DLL++ V+P S + + W FG++ C+IW + D+ CCTASI+ LC+I++DRY
Sbjct: 67 NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
Query: 139 AITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISY 197
++ L Y T + VWA+S+ ISI PLF WRQ A E+ + C +N + Y
Sbjct: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQ-PAPEDETICQIN-EEPGY 184
Query: 198 TIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLN 257
++S G+FY+P +++++Y R+Y A+ R + L T + S +L
Sbjct: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRE---------SRGLKSGLKTDKSDSEQVTLR 235
Query: 258 SSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPF 317
+H ++ + GS + K + L+ +RE+KA K LGI++G F++CWLPF
Sbjct: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFVLCWLPF 288
Query: 318 FVVSLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
F LV+PI P+ +F WLGYLNS INPIIY ++EF++AFQ ++
Sbjct: 289 F---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 209 bits (532), Expect = 3e-54
Identities = 125/356 (35%), Positives = 196/356 (55%), Gaps = 26/356 (7%)
Query: 21 NATETSEAWDPRTLQALK--ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIG 78
NA+++S P + I L V+L + L VL N V+ ++ R LH+ +Y I
Sbjct: 7 NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
Query: 79 SLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYW 138
+LA DLL++ V+P S + + W FG++ C+IW + D+ CCTASI+ LC+I++DRY
Sbjct: 67 NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
Query: 139 AITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISY 197
++ L Y T + VWA+S+ ISI PLF WRQ A E+ + C +N + Y
Sbjct: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQ-PAPEDETICQIN-EEPGY 184
Query: 198 TIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLN 257
++S G+FY+P +++++Y R+Y A+ R + L T + S +L
Sbjct: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRE---------SRGLKSGLKTDKSDSEQVTLR 235
Query: 258 SSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPF 317
+H ++ + GS + K + L+ +RE+KA K LGI++G F++CWLPF
Sbjct: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFVLCWLPF 288
Query: 318 FVVSLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
F LV+PI P+ +F WLGYLNS INPIIY ++EF++AFQ ++
Sbjct: 289 F---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 209 bits (532), Expect = 3e-54
Identities = 125/356 (35%), Positives = 196/356 (55%), Gaps = 26/356 (7%)
Query: 21 NATETSEAWDPRTLQALK--ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIG 78
NA+++S P + I L V+L + L VL N V+ ++ R LH+ +Y I
Sbjct: 7 NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
Query: 79 SLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYW 138
+LA DLL++ V+P S + + W FG++ C+IW + D+ CCTASI+ LC+I++DRY
Sbjct: 67 NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
Query: 139 AITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISY 197
++ L Y T + VWA+S+ ISI PLF WRQ A E+ + C +N + Y
Sbjct: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQ-PAPEDETICQIN-EEPGY 184
Query: 198 TIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLN 257
++S G+FY+P +++++Y R+Y A+ R + L T + S +L
Sbjct: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRE---------SRGLKSGLKTDKSDSEQVTLR 235
Query: 258 SSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPF 317
+H ++ + GS + K + L+ +RE+KA K LGI++G F++CWLPF
Sbjct: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFVLCWLPF 288
Query: 318 FVVSLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
F LV+PI P+ +F WLGYLNS INPIIY ++EF++AFQ ++
Sbjct: 289 F---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 209 bits (532), Expect = 3e-54
Identities = 125/356 (35%), Positives = 196/356 (55%), Gaps = 26/356 (7%)
Query: 21 NATETSEAWDPRTLQALK--ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIG 78
NA+++S P + I L V+L + L VL N V+ ++ R LH+ +Y I
Sbjct: 7 NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
Query: 79 SLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYW 138
+LA DLL++ V+P S + + W FG++ C+IW + D+ CCTASI+ LC+I++DRY
Sbjct: 67 NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
Query: 139 AITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISY 197
++ L Y T + VWA+S+ ISI PLF WRQ A E+ + C +N + Y
Sbjct: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQ-PAPEDETICQIN-EEPGY 184
Query: 198 TIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLN 257
++S G+FY+P +++++Y R+Y A+ R + L T + S +L
Sbjct: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRE---------SRGLKSGLKTDKSDSEQVTLR 235
Query: 258 SSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPF 317
+H ++ + GS + K + L+ +RE+KA K LGI++G F++CWLPF
Sbjct: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFVLCWLPF 288
Query: 318 FVVSLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
F LV+PI P+ +F WLGYLNS INPIIY ++EF++AFQ ++
Sbjct: 289 F---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 207 bits (528), Expect = 1e-53
Identities = 127/372 (34%), Positives = 195/372 (52%), Gaps = 35/372 (9%)
Query: 5 NQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTIL 64
N + G Q +SN +L + + A IS+ +VL L ++ N V+ ++
Sbjct: 22 NANFTGPNQTSSNSTLPQLDITRA----------ISVGLVLGAFILFAIVGNILVILSVA 71
Query: 65 LTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTA 124
R L TP NY I +LA DLL+S V+P S A + W G+I CDIW + D+ CCTA
Sbjct: 72 CNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTA 131
Query: 125 SILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEE 184
SIL LC I++DRY + +L+Y T A + VW +S ISI PL + A +
Sbjct: 132 SILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPND 191
Query: 185 MSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHL 244
+C V T + Y ++S+ G+FYIP +++++Y R+Y A+ N + K + +
Sbjct: 192 DKECGV-TEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKE 250
Query: 245 IT---GSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATK 301
+T S +L+S+ +GH+ S++ K +RE+KA K
Sbjct: 251 LTLRIHSKNFHEDTLSSTKAKGHN----------------PRSSIAVKLFKFSREKKAAK 294
Query: 302 ILGIILGAFIICWLPFFVVSLVLPICRDSCWIHP--ALFDFFTWLGYLNSLINPIIYTVF 359
LGI++G FI+CWLPFF+ LP+ + P A+F WLGY NS +NPIIY
Sbjct: 295 TLGIVVGMFILCWLPFFI---ALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCS 351
Query: 360 NEEFRQAFQKIV 371
++EF++AF +I+
Sbjct: 352 SKEFKRAFVRIL 363
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 195 bits (496), Expect = 5e-50
Identities = 127/373 (34%), Positives = 189/373 (50%), Gaps = 50/373 (13%)
Query: 42 AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIT 101
A+ + LA V N V +L R L T NYL+ SLA DLLV+ LVMP + +T
Sbjct: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92
Query: 102 H-TWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEY---SKRRTAGHAAT 157
WNF +I CD++++ D+ CTASIL+LC I++DRY A+ + Y + + + A
Sbjct: 93 GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 152
Query: 158 MIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217
MI VW ++ +S P LF + + S + IYS+ +FY+P + +++Y
Sbjct: 153 MITAVWVLAFAVSCPLLFGFNTTG----DPTVCSISNPDFVIYSSVVSFYLPFGVTVLVY 208
Query: 218 GRIY----RAARNRIL---------------------NPPSLYGKRFTTAHLITGSAGSS 252
RIY + R RIL +P L KR+ + T G
Sbjct: 209 ARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPG 268
Query: 253 LCSLNSSL-HEGHSHSAGSPLFFNHVKIKLADSALERKRISAA-------------RERK 298
L E + ++ SP K+ L L R+S + RE+K
Sbjct: 269 FQERGGELKREEKTRNSLSPTI--APKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKK 326
Query: 299 ATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTV 358
AT+++ I+LGAFI+CWLPFF+ ++ C+ +C + P L+ TWLGY+NS +NP+IYT
Sbjct: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ-TCHVSPELYSATTWLGYVNSALNPVIYTT 385
Query: 359 FNEEFRQAFQKIV 371
FN EFR+AF KI+
Sbjct: 386 FNIEFRKAFLKIL 398
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 195 bits (496), Expect = 5e-50
Identities = 124/359 (34%), Positives = 185/359 (51%), Gaps = 57/359 (15%)
Query: 36 ALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPA-NYLIGSLATTDLLVSILVMPI 94
+++I A LS++ L+T+L N V ++ R L + N+ + SLA +DLLV++LVMP
Sbjct: 21 SVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPW 80
Query: 95 SIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGH 154
I W FG C+IW++ DI C TASIL+LCVI++DRYWAI+ Y ++ T
Sbjct: 81 KAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKA 139
Query: 155 AATMIAIVWAISICISIPP--LFWRQAK-----------AQEEMSDCLVNTSQISYTIYS 201
A +I++ W +S+ IS P L W +AK E + +C + S+ +Y I S
Sbjct: 140 AFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSR-TYAISS 198
Query: 202 TCGAFYIPSVLLIILYGRIYRAARNRI-----LNPPSLYGKRFTTAHLITGSAGSSLCSL 256
+ +FYIP ++I+ Y RIYR A+ +I L +++ K T TG+ CS
Sbjct: 199 SVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTT---TGNGKPVECSQ 255
Query: 257 NSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLP 316
S ++S RE K K L +I+G F+ CWLP
Sbjct: 256 PESSF----------------------------KMSFKRETKVLKTLSVIMGVFVCCWLP 287
Query: 317 FFVVSLVLPIC----RDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
FF+++ +LP C I FD F W G+ NS +NPIIY FN +FR+AF ++
Sbjct: 288 FFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIY-AFNADFRKAFSTLL 345
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 194 bits (493), Expect = 1e-49
Identities = 120/339 (35%), Positives = 178/339 (52%), Gaps = 15/339 (4%)
Query: 42 AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIT 101
A+ + LA V N V +L R L T NYL+ SLA DLLV+ LVMP + +T
Sbjct: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92
Query: 102 H-TWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEY---SKRRTAGHAAT 157
WNF +I CD++++ D+ CTASIL+LC I++DRY A+ + Y + + + A
Sbjct: 93 GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 152
Query: 158 MIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217
MI VW ++ +S P LF + + S + IYS+ +FY+P + +++Y
Sbjct: 153 MITAVWVLAFAVSCPLLFGFNTTG----DPTVCSISNPDFVIYSSVVSFYLPFGVTVLVY 208
Query: 218 GRIY----RAARNRILNPPSLYGKRFTTAH-LITGSAGSSLCSLNSSLHEGHSHSAGSPL 272
RIY + R RIL + T S + L + G P
Sbjct: 209 ARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP- 267
Query: 273 FFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCW 332
F +L R + RE+KAT+++ I+LGAFI+CWLPFF+ ++ C+ +C
Sbjct: 268 GFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ-TCH 326
Query: 333 IHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
+ P L+ TWLGY+NS +NP+IYT FN EFR+AF KI+
Sbjct: 327 VSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 192 bits (489), Expect = 3e-49
Identities = 127/382 (33%), Positives = 185/382 (48%), Gaps = 59/382 (15%)
Query: 42 AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIT 101
A +L+++ V N V + + L T NYLI SLA DLLV+ LVMP + +
Sbjct: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
Query: 102 HTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAT-MIA 160
W F +I CDI+++ D+ CTASIL+LC I++DRY A+ + Y+ R ++ T MI+
Sbjct: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
Query: 161 IVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRI 220
IVW +S IS P LF Q E C++ + ++ +YS+ +FY+P ++ +++Y +I
Sbjct: 158 IVWVLSFTISCPLLFGLNNADQNE---CII--ANPAFVVYSSIVSFYVPFIVTLLVYIKI 212
Query: 221 YRAARNRILNPPSLYGKRFTTAHLIT-------------------------------GSA 249
Y R R + R AHL +
Sbjct: 213 YIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPS 272
Query: 250 GSSLCSLNSSLHEGHS------------HSAGSPLFFNHVKIKLADSALERKRISAARER 297
L + S H HS H+ P +I+ + R + R
Sbjct: 273 HHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRR 332
Query: 298 K--------ATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNS 349
K AT++L I+LG FIICWLPFF+ ++ C C I P L+ FTWLGY+NS
Sbjct: 333 KLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHC--DCNIPPVLYSAFTWLGYVNS 390
Query: 350 LINPIIYTVFNEEFRQAFQKIV 371
+NPIIYT FN EFR+AF KI+
Sbjct: 391 AVNPIIYTTFNIEFRKAFLKIL 412
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 191 bits (486), Expect = 7e-49
Identities = 114/371 (30%), Positives = 192/371 (51%), Gaps = 22/371 (5%)
Query: 5 NQSAEGLPQEA-SNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTI 63
N+S+ G P A + +N T A + A + + V L+ L V N V+ ++
Sbjct: 65 NRSSAGEPGSAGAGGDVNGTA---AVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSV 121
Query: 64 LLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCT 123
R L T NY I +LA DLL+S V+P S + W FG+ CD+W + D+ CCT
Sbjct: 122 ACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCT 181
Query: 124 ASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQ 182
ASIL LC I++DRY + +L+Y T AA ++A++W +++ +S+ PL W++
Sbjct: 182 ASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPP 241
Query: 183 EEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTA 242
+E C + T + Y ++S+ +FY+P +++++Y R+Y AR+ + + +
Sbjct: 242 DERF-CGI-TEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRE---- 295
Query: 243 HLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKI 302
G A + ++ G + A K S+L + + +RE+KA K
Sbjct: 296 ---RGKASEVVLRIHC---RGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKT 349
Query: 303 LGIILGAFIICWLPFFVVSLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPIIYTVFN 360
L I++G F++CW PFF VLP+ + P+ +F WLGY NS +NP+IY +
Sbjct: 350 LAIVVGVFVLCWFPFF---FVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSS 406
Query: 361 EEFRQAFQKIV 371
EF++AF +++
Sbjct: 407 REFKRAFLRLL 417
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 189 bits (479), Expect = 5e-48
Identities = 115/348 (33%), Positives = 179/348 (51%), Gaps = 44/348 (12%)
Query: 39 ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAY 98
+ + +V+S+I LA V N V+T I +L T NY I SLA DL++ + V+P A+
Sbjct: 34 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAH 93
Query: 99 TITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATM 158
+ W FG C+ W S D+ C TASI LCVIA+DRY+AIT +Y T A +
Sbjct: 94 ILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVI 153
Query: 159 IAIVWAISICISIPP--LFWRQAKAQEEMSDCLVN-------TSQISYTIYSTCGAFYIP 209
I +VW +S S P + W +A QE + +C N T+Q +Y I S+ +FY+P
Sbjct: 154 ILMVWIVSGLTSFLPIQMHWYRATHQEAI-NCYANETCCDFFTNQ-AYAIASSIVSFYVP 211
Query: 210 SVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAG 269
V+++ +Y R+++ A+ ++ G+ +L + GH
Sbjct: 212 LVIMVFVYSRVFQEAKRQLQKIDKSEGRFHV----------QNLSQVEQDGRTGH----- 256
Query: 270 SPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRD 329
L R +E KA K LGII+G F +CWLPFF+V++V + +D
Sbjct: 257 ---------------GLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIV-HVIQD 300
Query: 330 SCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS 377
+ I ++ W+GY+NS NP+IY + +FR AFQ+++ R++S
Sbjct: 301 NL-IRKEVYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELLCLRRSS 346
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 183 bits (464), Expect = 3e-46
Identities = 120/356 (33%), Positives = 181/356 (50%), Gaps = 21/356 (5%)
Query: 26 SEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDL 85
SE+ +P + Q + +++++I L V N V+ I T +L T N I SLA+ DL
Sbjct: 47 SESPEPLS-QQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADL 105
Query: 86 LVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALE 145
++ +LV+P + W +G C++W S D+ C TASI LCVIALDRY AIT
Sbjct: 106 VMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFR 165
Query: 146 YSKRRTAGHAATMIAIVWAISICISIPPLF--WRQAKAQEEM-----SDCLVNTSQISYT 198
Y T A ++ VWAIS +S P+ W +A++ E C + +Y
Sbjct: 166 YQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYA 225
Query: 199 IYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNS 258
I S+ +FY+P ++ +Y R++R A+ ++ S +RF S S +
Sbjct: 226 IASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSC-ERRFLGGPARPPSPSPSPVPAPA 284
Query: 259 SLHEGHSHSAGSPLFFNHVKIKLADSALERKRIS---AARERKATKILGIILGAFIICWL 315
+A + LA+ ++R S A RE+KA K LGII+G F +CWL
Sbjct: 285 PPPGPPRPAAAA------ATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWL 338
Query: 316 PFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
PFF+ ++V R+ + LF FF WLGY NS NPIIY + +FR+AFQ ++
Sbjct: 339 PFFLANVVKAFHRE--LVPDRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLL 391
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 177 bits (450), Expect = 1e-44
Identities = 108/330 (32%), Positives = 179/330 (54%), Gaps = 11/330 (3%)
Query: 42 AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISI-AYTI 100
A+ + +I + T+ N V+ + + +KLH NY + SLA D+LV +LVMP+S+ A
Sbjct: 57 ALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILY 116
Query: 101 THTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIA 160
+ W + LC +W+S D+ TASI+HLC I+LDRY AI + +E+S+ + A IA
Sbjct: 117 DYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIA 176
Query: 161 IVWAISICISIP-PLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGR 219
IVWAISI +S+P P+ + + + +++ + ++ + + AF+IP +++I Y
Sbjct: 177 IVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCL 236
Query: 220 IYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKI 279
R + L L+G L C N++ E +SA N +
Sbjct: 237 TIYVLRRQAL--MLLHGHTEEPPGLSLDFL--KCCKRNTAEEE---NSANPNQDQNARRR 289
Query: 280 KLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSC--WIHPAL 337
K + + ERKA+K+LGI+ F+I W PFF+ +++ +C SC + L
Sbjct: 290 KKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKL 349
Query: 338 FDFFTWLGYLNSLINPIIYTVFNEEFRQAF 367
+ F W+GY+ S INP++YT+FN+ +R+AF
Sbjct: 350 LNVFVWIGYVCSGINPLVYTLFNKIYRRAF 379
>gi|4503391 dopamine receptor D5 [Homo sapiens]
Length = 477
Score = 176 bits (447), Expect = 2e-44
Identities = 117/369 (31%), Positives = 178/369 (48%), Gaps = 70/369 (18%)
Query: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTP-ANYLIGSLATTDLLVSILVMPISI 96
++ A +L+++ + T+L N V I+ +R L N I SLA +DL V++LVMP
Sbjct: 40 QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
Query: 97 AYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAA 156
+ W FG CD+W++ DI C TASIL+LCVI++DRYWAI+ Y ++ T A
Sbjct: 100 VAEVAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMAL 158
Query: 157 TMIAIVWAISICISIPP--LFWRQAKA------------------QEEMSDCLVNTSQI- 195
M+ + W +SI IS P L W + +A +E+ + VN
Sbjct: 159 VMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCD 218
Query: 196 -----SYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAG 250
+Y I S+ +FYIP ++I+ Y RIYR A+ +I SL A
Sbjct: 219 SSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLE----RAAEHAQSCRS 274
Query: 251 SSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAF 310
S+ C+ ++SL R S +E K K L +I+G F
Sbjct: 275 SAACAPDTSL-----------------------------RASIKKETKVLKTLSVIMGVF 305
Query: 311 IICWLPFFVVSLVLPICRDSCWIHPA--------LFDFFTWLGYLNSLINPIIYTVFNEE 362
+ CWLPFF+++ ++P C PA FD F W G+ NS +NP+IY FN +
Sbjct: 306 VCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIY-AFNAD 364
Query: 363 FRQAFQKIV 371
F++ F +++
Sbjct: 365 FQKVFAQLL 373
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 175 bits (444), Expect = 5e-44
Identities = 113/348 (32%), Positives = 167/348 (47%), Gaps = 60/348 (17%)
Query: 36 ALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPIS 95
A KI++ VVL+V+ L TV N V + L R+L N I SLA TDLL+ +LV+P S
Sbjct: 16 ACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFS 75
Query: 96 IAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHA 155
Y ++ W+FG++ C+I+ S D+ CTASIL+L +I+LDRY A+ D L Y T
Sbjct: 76 AIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRV 135
Query: 156 ATMIAIVWAISICISIPP--LFWRQ----AKAQEEMSDCLVNTSQISYTIYSTCGAFYIP 209
A + ++W ISI +S L W +K S C V +++ Y + FY+P
Sbjct: 136 AISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEV-YGLVDGLVTFYLP 194
Query: 210 SVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAG 269
+++ I Y RI++ AR++ KR
Sbjct: 195 LLIMCITYYRIFKVARDQ--------AKR------------------------------- 215
Query: 270 SPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRD 329
NH+ + + RE KAT L ++GAFIICW P+F + + D
Sbjct: 216 ----INHI---------SSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGD 262
Query: 330 SCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS 377
I+ L WLGY NS +NPI+Y N +FR +Q++ R A+
Sbjct: 263 DA-INEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLAN 309
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 175 bits (444), Expect = 5e-44
Identities = 113/348 (32%), Positives = 167/348 (47%), Gaps = 60/348 (17%)
Query: 36 ALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPIS 95
A KI++ VVL+V+ L TV N V + L R+L N I SLA TDLL+ +LV+P S
Sbjct: 16 ACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFS 75
Query: 96 IAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHA 155
Y ++ W+FG++ C+I+ S D+ CTASIL+L +I+LDRY A+ D L Y T
Sbjct: 76 AIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRV 135
Query: 156 ATMIAIVWAISICISIPP--LFWRQ----AKAQEEMSDCLVNTSQISYTIYSTCGAFYIP 209
A + ++W ISI +S L W +K S C V +++ Y + FY+P
Sbjct: 136 AISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEV-YGLVDGLVTFYLP 194
Query: 210 SVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAG 269
+++ I Y RI++ AR++ KR
Sbjct: 195 LLIMCITYYRIFKVARDQ--------AKR------------------------------- 215
Query: 270 SPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRD 329
NH+ + + RE KAT L ++GAFIICW P+F + + D
Sbjct: 216 ----INHI---------SSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGD 262
Query: 330 SCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS 377
I+ L WLGY NS +NPI+Y N +FR +Q++ R A+
Sbjct: 263 DA-INEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLAN 309
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 174 bits (440), Expect = 2e-43
Identities = 107/338 (31%), Positives = 179/338 (52%), Gaps = 28/338 (8%)
Query: 42 AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIT 101
A++ +V+ + T+ N V+ + L +KL NY + SLA D+L+ LVMP+S+ +
Sbjct: 78 ALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILY 137
Query: 102 -HTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIA 160
+ W LC +W+ D+ TASI+HLC I+LDRY AI + + +S+ + A I
Sbjct: 138 GYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKII 197
Query: 161 IVWAISICISIP-PLFWRQ--AKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217
VW IS+ IS+P P+F Q +K +E S CL+ + ++ + + +F+IP +++I Y
Sbjct: 198 AVWTISVGISMPIPVFGLQDDSKVFKEGS-CLL--ADDNFVLIGSFVSFFIPLTIMVITY 254
Query: 218 GRIYRAARNRILNPPSLYGKRFTTA--HLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFN 275
++ + S G R A + S+ SS S+H G
Sbjct: 255 FLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTG------ 308
Query: 276 HVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSC--WI 333
R S + E+KA K+LGI+ F++ W PFF+ +++ IC++SC +
Sbjct: 309 -----------RRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDV 357
Query: 334 HPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
AL + F W+GYL+S +NP++YT+FN+ +R AF + +
Sbjct: 358 IGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYI 395
>gi|21264324 trace amine associated receptor 1 [Homo sapiens]
Length = 339
Score = 172 bits (435), Expect = 6e-43
Identities = 114/345 (33%), Positives = 171/345 (49%), Gaps = 57/345 (16%)
Query: 37 LKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISI 96
++ SL ++ +I L T++ N V+ +I ++LHTP N+LI S+AT D L+ LVMP S+
Sbjct: 22 VRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSM 81
Query: 97 AYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAA 156
+ H W FG++ C I S+DI +ASI HL I++DRY+A+ D L Y +
Sbjct: 82 VRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVIC 141
Query: 157 TMIAIVWAISICISIPPLFWR-QAKAQEEM--------SDCLVNTSQISYTIYSTCGAFY 207
MI I W++ + +F K EE+ C V S+IS + + +FY
Sbjct: 142 VMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKIS-GVLTFMTSFY 200
Query: 208 IPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHS 267
IP +++ +Y RIY A+ + A LI+ + N L G
Sbjct: 201 IPGSIMLCVYYRIYLIAKEQ--------------ARLISDA--------NQKLQIG---- 234
Query: 268 AGSPLFFNHVKIKLADSALERKR-ISAARERKATKILGIILGAFIICWLPFFVVSLVLPI 326
LE K IS ++ERKA K LGI++G F+ICW PFF+ +++ P
Sbjct: 235 ------------------LEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPF 276
Query: 327 CRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
I P L D W GYLNS NP++Y F FR+A + ++
Sbjct: 277 LH--YIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMML 319
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 167 bits (422), Expect = 2e-41
Identities = 107/338 (31%), Positives = 171/338 (50%), Gaps = 36/338 (10%)
Query: 41 LAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTI 100
+A L V+ T +N+ ++ I L +N+ + SL T+DL+V ++VMP ++ +
Sbjct: 29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88
Query: 101 THTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIA 160
W + LC +W + D+ CC+ASIL+LC+I+LDRY I L Y R T A ++
Sbjct: 89 YGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVL 148
Query: 161 IVWAISICISIPPLF--WRQ-AKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217
W+++ S PL W + A+ + + + + + ++ F++PS + Y
Sbjct: 149 GAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTY 208
Query: 218 GRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHV 277
RI AAR + + A L TG A + + +L + G
Sbjct: 209 CRILLAARKQAVQ----------VASLTTGMASQA----SETLQVPRTPRPG-------- 246
Query: 278 KIKLADSALERKRISAARERKATK---ILGIILGAFIICWLPFFVVSLVLPICRDSCWIH 334
++ ADS +R++ RKA K LGI+LG F + WLPFFV ++V +C C I
Sbjct: 247 -VESADS----RRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVC--DC-IS 298
Query: 335 PALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVP 372
P LFD TWLGY NS +NPIIY +F +F++A + +P
Sbjct: 299 PGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLP 336
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 162 bits (410), Expect = 5e-40
Identities = 112/369 (30%), Positives = 176/369 (47%), Gaps = 33/369 (8%)
Query: 11 LPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLH 70
LP A N + + W+ AL L++ LATV N V+ I T +L
Sbjct: 17 LPTLAPNTANTSGLPGVPWEAALAGAL-------LALAVLATVGGNLLVIVAIAWTPRLQ 69
Query: 71 TPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLC 130
T N + SLA DL++ +LV+P + +T W G C++W S D+ C TASI LC
Sbjct: 70 TMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLC 129
Query: 131 VIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPL---FWR---QAKAQEE 184
+A+DRY A+T+ L Y T A T + +VW +S +S P+ +WR A+AQ
Sbjct: 130 ALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRC 189
Query: 185 MSD--CLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTA 242
S+ C S + Y + S+ +FY+P ++++ +Y R++ A ++
Sbjct: 190 HSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQL-------------- 235
Query: 243 HLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKI 302
L+ G G S A +P+ + R+ RE +A
Sbjct: 236 RLLRGELGR--FPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCT 293
Query: 303 LGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEE 362
LG+I+G F +CWLPFF+ +++ + S PA F WLGY NS NP+IY + +
Sbjct: 294 LGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPA-FLALNWLGYANSAFNPLIY-CRSPD 351
Query: 363 FRQAFQKIV 371
FR AF++++
Sbjct: 352 FRSAFRRLL 360
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 161 bits (407), Expect = 1e-39
Identities = 90/233 (38%), Positives = 132/233 (56%), Gaps = 8/233 (3%)
Query: 11 LPQEASNRSLNATETSEAWDPRTLQALKISLAVVL--SVITLATVLSNAFVLTTILLTRK 68
L +A N S N TE T +L+++L +V ++ L TV N V+ + +R
Sbjct: 19 LQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRA 78
Query: 69 LHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILH 128
L P N + SLA+ D+LV+ LV+P S+A + W FG+ C+I+L+ D+ CT+SI+H
Sbjct: 79 LKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVH 138
Query: 129 LCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKA-----QE 183
LC I+LDRYW+IT A+EY+ +RT +I VW IS IS PPL + K Q
Sbjct: 139 LCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQP 198
Query: 184 EMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYG 236
C +N Q Y I S G+F+ P +++I++Y RIY+ A+ R PPS G
Sbjct: 199 AEPRCEIN-DQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRG 250
Score = 85.1 bits (209), Expect = 9e-17
Identities = 34/77 (44%), Positives = 52/77 (67%), Gaps = 3/77 (3%)
Query: 295 RERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPI 354
RE++ T +L +++G F++CW PFF + + C + LF FF W GY NS +NP+
Sbjct: 383 REKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV---GCSVPRTLFKFFFWFGYCNSSLNPV 439
Query: 355 IYTVFNEEFRQAFQKIV 371
IYT+FN +FR+AF+KI+
Sbjct: 440 IYTIFNHDFRRAFKKIL 456
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.136 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,030,561
Number of Sequences: 37866
Number of extensions: 515004
Number of successful extensions: 3559
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 538
Number of HSP's successfully gapped in prelim test: 175
Number of HSP's that attempted gapping in prelim test: 1812
Number of HSP's gapped (non-prelim): 1363
length of query: 377
length of database: 18,247,518
effective HSP length: 104
effective length of query: 273
effective length of database: 14,309,454
effective search space: 3906480942
effective search space used: 3906480942
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.