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Search of human proteins with 4504373
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504373 hexosaminidase B preproprotein [Homo sapiens]
(556 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504373 hexosaminidase B preproprotein [Homo sapiens] 1142 0.0
gi|189181666 hexosaminidase A preproprotein [Homo sapiens] 610 e-174
gi|150456449 hexosaminidase (glycosyl hydrolase family 20, catal... 33 0.90
gi|113205091 BAI1-associated protein 2-like 2 [Homo sapiens] 33 0.90
gi|27881484 zinc finger CCCH-type containing 7B [Homo sapiens] 32 1.2
gi|166795299 solute carrier family 2 (facilitated glucose transp... 32 1.5
gi|134053883 intestinal facilitative glucose transporter 7 [Homo... 32 1.5
gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo sa... 31 2.6
gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo sa... 31 2.6
gi|31742501 sorting nexin family member 27 [Homo sapiens] 30 4.4
gi|239757668 PREDICTED: similar to Ig lambda chain [Homo sapiens] 30 5.8
gi|146134388 YLP motif containing 1 [Homo sapiens] 30 5.8
gi|239753928 PREDICTED: hypothetical protein [Homo sapiens] 29 9.9
gi|239748470 PREDICTED: hypothetical protein [Homo sapiens] 29 9.9
gi|239742434 PREDICTED: hypothetical protein XP_002342514 [Homo ... 29 9.9
gi|34330168 olfactory receptor, family 6, subfamily A, member 2 ... 29 9.9
>gi|4504373 hexosaminidase B preproprotein [Homo sapiens]
Length = 556
Score = 1142 bits (2955), Expect = 0.0
Identities = 556/556 (100%), Positives = 556/556 (100%)
Query: 1 MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLP 60
MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLP
Sbjct: 1 MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLP 60
Query: 61 LSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQA 120
LSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQA
Sbjct: 61 LSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQA 120
Query: 121 KTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY 180
KTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY
Sbjct: 121 KTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY 180
Query: 181 QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVD 240
QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVD
Sbjct: 181 QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVD 240
Query: 241 DQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGK 300
DQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGK
Sbjct: 241 DQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGK 300
Query: 301 GQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKC 360
GQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKC
Sbjct: 301 GQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKC 360
Query: 361 WESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTI 420
WESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTI
Sbjct: 361 WESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTI 420
Query: 421 VEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQL 480
VEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQL
Sbjct: 421 VEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQL 480
Query: 481 FIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERG 540
FIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERG
Sbjct: 481 FIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERG 540
Query: 541 IAAQPLYAGYCNHENM 556
IAAQPLYAGYCNHENM
Sbjct: 541 IAAQPLYAGYCNHENM 556
>gi|189181666 hexosaminidase A preproprotein [Homo sapiens]
Length = 529
Score = 610 bits (1572), Expect = e-174
Identities = 287/504 (56%), Positives = 364/504 (72%), Gaps = 4/504 (0%)
Query: 55 ALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHE 114
ALWP P + + + L P NF + +S A P C++L+EAF+RY +FG W
Sbjct: 22 ALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRP 81
Query: 115 PAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLET 174
+ T + +LV + C+ P + S E+YTL + + +L + VWGALRGLET
Sbjct: 82 YLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLET 141
Query: 175 FSQLVYQDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVL 234
FSQLV++ + GTF IN++ I D PRF HRG+L+DTSRHYLP+ IL TLD MA+NK NV
Sbjct: 142 FSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVF 201
Query: 235 HWHIVDDQSFPYQSITFPELSNKGSYS-LSHVYTPNDVRMVIEYARLRGIRVLPEFDTPG 293
HWH+VDD SFPY+S TFPEL KGSY+ ++H+YT DV+ VIEYARLRGIRVL EFDTPG
Sbjct: 202 HWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPG 261
Query: 294 HTLSWGKGQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGG 353
HTLSWG G LLTPCYS +FGP+NP+LN TY F++TFF E+S VFPD ++HLGG
Sbjct: 262 HTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGG 321
Query: 354 DEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKA 413
DEV+F CW+SNP+IQDFMR+KGFG DFK+LESFYIQ +LDI+++ KG +VWQEVFD+K
Sbjct: 322 DEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKV 381
Query: 414 KLAPGTIVEVWKDSA---YPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLD 470
K+ P TI++VW++ Y +EL VT +GF +LSAPWYL+ ISYG DW+ +Y VEPL
Sbjct: 382 KIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLA 441
Query: 471 FGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLT 530
F GT +QK L IGGEAC+WGEYVD TNL PRLWPRA AV ERLWS+K D+ AY+RL+
Sbjct: 442 FEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLS 501
Query: 531 RHRCRMVERGIAAQPLYAGYCNHE 554
RC ++ RG+ AQPL G+C E
Sbjct: 502 HFRCELLRRGVQAQPLNVGFCEQE 525
>gi|150456449 hexosaminidase (glycosyl hydrolase family 20,
catalytic domain) containing [Homo sapiens]
Length = 585
Score = 32.7 bits (73), Expect = 0.90
Identities = 22/97 (22%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 264 HVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFG-PI 322
+ Y+P++++ ++ A L + V+P T GH + L ++ ++ SF +
Sbjct: 62 YAYSPSEIKEILHLAGLNELEVIPLVQTFGHM------EFVLKHTAFAHLREVGSFPCTL 115
Query: 323 NPTLNTTYSFLTTFFKEISEVFPD-QFIHLGGDEVEF 358
NP + + + ++ E+ P Q +H+G DEV +
Sbjct: 116 NPHEAESLALVGAMIDQVLELHPGAQRLHIGCDEVYY 152
>gi|113205091 BAI1-associated protein 2-like 2 [Homo sapiens]
Length = 529
Score = 32.7 bits (73), Expect = 0.90
Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 29 LLTQVALVVQVAEAARAPSVSAKPG---PALWPLPLSVKMTPNLLHLAPENFYISHSPNS 85
L +V L + +EA+R+PS + PG PAL P S ++TP L + P SP S
Sbjct: 209 LQNRVLLWKEQSEASRSPSRAHSPGLLGPALGPPYPSGRLTPTCLDMPPRPLGEFSSPRS 268
Query: 86 TAG 88
G
Sbjct: 269 RHG 271
>gi|27881484 zinc finger CCCH-type containing 7B [Homo sapiens]
Length = 977
Score = 32.3 bits (72), Expect = 1.2
Identities = 24/76 (31%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 258 GSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLD 317
GS +S P +V++ ++ VL D PG TL DLL +R + LD
Sbjct: 308 GSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLD----PLDLLPYSETRLDALD 363
Query: 318 SFGPINPTLNTTYSFL 333
SFG +L+ SF+
Sbjct: 364 SFGSTRGSLDKPDSFM 379
>gi|166795299 solute carrier family 2 (facilitated glucose
transporter), member 1 [Homo sapiens]
Length = 492
Score = 32.0 bits (71), Expect = 1.5
Identities = 23/67 (34%), Positives = 29/67 (43%)
Query: 4 CGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSV 63
CGL PM + + T L L L Q+ +VV + A S LWPL LS+
Sbjct: 133 CGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSI 192
Query: 64 KMTPNLL 70
P LL
Sbjct: 193 IFIPALL 199
>gi|134053883 intestinal facilitative glucose transporter 7 [Homo
sapiens]
Length = 512
Score = 32.0 bits (71), Expect = 1.5
Identities = 30/103 (29%), Positives = 44/103 (42%), Gaps = 5/103 (4%)
Query: 5 GLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVK 64
G+ PM L L L M+ +T+V ++V V A + PA WP+ L++
Sbjct: 146 GISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQIFSLQAILGNPAGWPVLLALT 205
Query: 65 MTPNLLHLAPENFYISHSPNST---AGPSCTLLEEAFRRYHGY 104
P LL L F+ SP + G T +A RR G+
Sbjct: 206 GVPALLQLLTLPFF-PESPRYSLIQKGDEAT-ARQALRRLRGH 246
>gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo
sapiens]
Length = 607
Score = 31.2 bits (69), Expect = 2.6
Identities = 38/135 (28%), Positives = 55/135 (40%), Gaps = 21/135 (15%)
Query: 9 PRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPN 68
P PP+LL L L LL A A ++ A+ PSVS L LS
Sbjct: 25 PPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVS---------LYLSEDEVRR 75
Query: 69 LLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWH-HEPAEFQAKTQVQQL 127
L+ L E +Y+ + S S +LL + F + WH E++ QV +
Sbjct: 76 LIGLDAELYYVRNDLISHYALSFSLLVPSETN-----FLHFTWHAKSKVEYKLGFQVDNV 130
Query: 128 L------VSITLQSE 136
L V+I++Q E
Sbjct: 131 LAMDMPQVNISVQGE 145
>gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo
sapiens]
Length = 610
Score = 31.2 bits (69), Expect = 2.6
Identities = 38/135 (28%), Positives = 55/135 (40%), Gaps = 21/135 (15%)
Query: 9 PRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPN 68
P PP+LL L L LL A A ++ A+ PSVS L LS
Sbjct: 25 PPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVS---------LYLSEDEVRR 75
Query: 69 LLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWH-HEPAEFQAKTQVQQL 127
L+ L E +Y+ + S S +LL + F + WH E++ QV +
Sbjct: 76 LIGLDAELYYVRNDLISHYALSFSLLVPSETN-----FLHFTWHAKSKVEYKLGFQVDNV 130
Query: 128 L------VSITLQSE 136
L V+I++Q E
Sbjct: 131 LAMDMPQVNISVQGE 145
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 30.4 bits (67), Expect = 4.4
Identities = 28/118 (23%), Positives = 53/118 (44%), Gaps = 10/118 (8%)
Query: 183 SYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIIL--KTLDAMAFNKFNVLHWHIVD 240
S+ +T ++ I PR+ H + ++ + + + L + + +F +LH ++
Sbjct: 153 SFYDYTEKQAVPISVPRYKH---VEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKR 209
Query: 241 DQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEY-ARLRGIRVLPEFDTPGHTLS 297
+ + + TFP L K +SLS R + EY ++ IRV+ E D LS
Sbjct: 210 E----FANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLS 263
>gi|239757668 PREDICTED: similar to Ig lambda chain [Homo sapiens]
Length = 288
Score = 30.0 bits (66), Expect = 5.8
Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 1/87 (1%)
Query: 7 GLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAP-SVSAKPGPALWPLPLSVKM 65
GL P + L +L + AA +T+ L+ V R ++ A P P LWP LS
Sbjct: 134 GLSGPLLALKMLPHPVQAASCRTVTRSFLIDAVTAFFRDVFTLHASPSPTLWPPLLSSPA 193
Query: 66 TPNLLHLAPENFYISHSPNSTAGPSCT 92
+ + +S SP TA SC+
Sbjct: 194 GSVASYELTQPPAVSVSPGQTARISCS 220
>gi|146134388 YLP motif containing 1 [Homo sapiens]
Length = 2146
Score = 30.0 bits (66), Expect = 5.8
Identities = 19/57 (33%), Positives = 26/57 (45%), Gaps = 9/57 (15%)
Query: 34 ALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPS 90
A V A ++++ V KP PAL P P+S P + H P +AGPS
Sbjct: 648 AAPVPPASSSQSSQVPEKPRPALLPTPVSFGSAPPTTY---------HPPLQSAGPS 695
>gi|239753928 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1179
Score = 29.3 bits (64), Expect = 9.9
Identities = 22/80 (27%), Positives = 35/80 (43%), Gaps = 2/80 (2%)
Query: 25 AMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPN 84
A+ LL Q ++ A A+ P + + PG L L L P LL L Y++
Sbjct: 653 ALCTLLGQQLHIILTAAPAKCPQLPSCPGALLLLLLLQPLQLPQLLRLPVVVMYLNCFVE 712
Query: 85 STAGPSCTLLEEAFRRYHGY 104
G + +AF ++HG+
Sbjct: 713 --FGTEISKYLKAFIQFHGF 730
>gi|239748470 PREDICTED: hypothetical protein [Homo sapiens]
Length = 889
Score = 29.3 bits (64), Expect = 9.9
Identities = 22/80 (27%), Positives = 35/80 (43%), Gaps = 2/80 (2%)
Query: 25 AMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPN 84
A+ LL Q ++ A A+ P + + PG L L L P LL L Y++
Sbjct: 653 ALCTLLGQQLHIILTAAPAKCPQLPSCPGALLLLLLLQPLQLPQLLRLPVVVMYLNCFVE 712
Query: 85 STAGPSCTLLEEAFRRYHGY 104
G + +AF ++HG+
Sbjct: 713 --FGTEISKYLKAFIQFHGF 730
>gi|239742434 PREDICTED: hypothetical protein XP_002342514 [Homo
sapiens]
Length = 889
Score = 29.3 bits (64), Expect = 9.9
Identities = 22/80 (27%), Positives = 35/80 (43%), Gaps = 2/80 (2%)
Query: 25 AMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPN 84
A+ LL Q ++ A A+ P + + PG L L L P LL L Y++
Sbjct: 653 ALCTLLGQQLHIILTAAPAKCPQLPSCPGALLLLLLLQPLQLPQLLRLPVVVMYLNCFVE 712
Query: 85 STAGPSCTLLEEAFRRYHGY 104
G + +AF ++HG+
Sbjct: 713 --FGTEISKYLKAFIQFHGF 730
>gi|34330168 olfactory receptor, family 6, subfamily A, member 2
[Homo sapiens]
Length = 327
Score = 29.3 bits (64), Expect = 9.9
Identities = 19/47 (40%), Positives = 24/47 (51%), Gaps = 3/47 (6%)
Query: 6 LGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKP 52
LG P P L LL A LL A + +LT+ L++ A R S KP
Sbjct: 16 LGFPAPAPLQVLLFALLLLAYVLVLTENTLIIM---AIRNHSTLHKP 59
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,032,503
Number of Sequences: 37866
Number of extensions: 999964
Number of successful extensions: 2354
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2346
Number of HSP's gapped (non-prelim): 17
length of query: 556
length of database: 18,247,518
effective HSP length: 107
effective length of query: 449
effective length of database: 14,195,856
effective search space: 6373939344
effective search space used: 6373939344
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.