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Search of human proteins with 4503647
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503647 coagulation factor VIII isoform a precursor [Homo
sapiens]
(2351 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503647 coagulation factor VIII isoform a precursor [Homo sap... 4788 0.0
gi|105990535 coagulation factor V precursor [Homo sapiens] 532 e-150
gi|148886707 hephaestin-like 1 [Homo sapiens] 471 e-132
gi|10518506 coagulation factor VIII isoform b precursor [Homo sa... 429 e-119
gi|4557485 ceruloplasmin precursor [Homo sapiens] 426 e-118
gi|195963313 hephaestin isoform a [Homo sapiens] 417 e-116
gi|195947365 hephaestin isoform c [Homo sapiens] 417 e-116
gi|7662254 hephaestin isoform b [Homo sapiens] 387 e-107
gi|31317224 EGF-like repeats and discoidin I-like domains-contai... 255 4e-67
gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Ho... 224 8e-58
gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Ho... 175 5e-43
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 164 9e-40
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens] 164 9e-40
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens] 164 9e-40
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens] 164 9e-40
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens] 164 9e-40
gi|66864913 neuropilin 1 isoform c [Homo sapiens] 160 1e-38
gi|66912178 neuropilin 1 isoform b [Homo sapiens] 160 1e-38
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 160 1e-38
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens] 134 1e-30
gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo sa... 120 2e-26
gi|27735143 discoidin, CUB and LCCL domain containing 1 [Homo sa... 110 2e-23
gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo... 102 3e-21
gi|223005864 carboxypeptidase X (M14 family), member 2 [Homo sap... 101 8e-21
gi|10835083 X-linked juvenile retinoschisis protein precursor [H... 96 4e-19
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi... 84 2e-15
gi|9994201 carboxypeptidase X, member 1 precursor [Homo sapiens] 82 5e-15
gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sap... 80 2e-14
gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sap... 80 2e-14
gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2... 77 2e-13
>gi|4503647 coagulation factor VIII isoform a precursor [Homo sapiens]
Length = 2351
Score = 4788 bits (12418), Expect = 0.0
Identities = 2351/2351 (100%), Positives = 2351/2351 (100%)
Query: 1 MQIELSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFN 60
MQIELSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFN
Sbjct: 1 MQIELSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFN 60
Query: 61 TSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAV 120
TSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAV
Sbjct: 61 TSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAV 120
Query: 121 GVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSH 180
GVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSH
Sbjct: 121 GVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSH 180
Query: 181 VDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRD 240
VDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRD
Sbjct: 181 VDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRD 240
Query: 241 AASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH 300
AASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH
Sbjct: 241 AASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH 300
Query: 301 RQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNE 360
RQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNE
Sbjct: 301 RQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNE 360
Query: 361 EAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLA 420
EAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLA
Sbjct: 361 EAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLA 420
Query: 421 PDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTL 480
PDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTL
Sbjct: 421 PDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTL 480
Query: 481 LIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGP 540
LIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGP
Sbjct: 481 LIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGP 540
Query: 541 TKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDE 600
TKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDE
Sbjct: 541 TKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDE 600
Query: 601 NRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILS 660
NRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILS
Sbjct: 601 NRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILS 660
Query: 661 IGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRG 720
IGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRG
Sbjct: 661 IGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRG 720
Query: 721 MTALLKVSSCDKNTGDYYEDSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATTI 780
MTALLKVSSCDKNTGDYYEDSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATTI
Sbjct: 721 MTALLKVSSCDKNTGDYYEDSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATTI 780
Query: 781 PENDIEKTDPWFAHRTPMPKIQNVSSSDLLMLLRQSPTPHGLSLSDLQEAKYETFSDDPS 840
PENDIEKTDPWFAHRTPMPKIQNVSSSDLLMLLRQSPTPHGLSLSDLQEAKYETFSDDPS
Sbjct: 781 PENDIEKTDPWFAHRTPMPKIQNVSSSDLLMLLRQSPTPHGLSLSDLQEAKYETFSDDPS 840
Query: 841 PGAIDSNNSLSEMTHFRPQLHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDFKVSST 900
PGAIDSNNSLSEMTHFRPQLHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDFKVSST
Sbjct: 841 PGAIDSNNSLSEMTHFRPQLHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDFKVSST 900
Query: 901 SNNLISTIPSDNLAAGTDNTSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGPLSLSEE 960
SNNLISTIPSDNLAAGTDNTSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGPLSLSEE
Sbjct: 901 SNNLISTIPSDNLAAGTDNTSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGPLSLSEE 960
Query: 961 NNDSKLLESGLMNSQESSWGKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSISLLKTN 1020
NNDSKLLESGLMNSQESSWGKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSISLLKTN
Sbjct: 961 NNDSKLLESGLMNSQESSWGKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSISLLKTN 1020
Query: 1021 KTSNNSATNRKTHIDGPSLLIENSPSVWQNILESDTEFKKVTPLIHDRMLMDKNATALRL 1080
KTSNNSATNRKTHIDGPSLLIENSPSVWQNILESDTEFKKVTPLIHDRMLMDKNATALRL
Sbjct: 1021 KTSNNSATNRKTHIDGPSLLIENSPSVWQNILESDTEFKKVTPLIHDRMLMDKNATALRL 1080
Query: 1081 NHMSNKTTSSKNMEMVQQKKEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHGKNSLNSG 1140
NHMSNKTTSSKNMEMVQQKKEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHGKNSLNSG
Sbjct: 1081 NHMSNKTTSSKNMEMVQQKKEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHGKNSLNSG 1140
Query: 1141 QGPSPKQLVSLGPEKSVEGQNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNLFLTNLDN 1200
QGPSPKQLVSLGPEKSVEGQNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNLFLTNLDN
Sbjct: 1141 QGPSPKQLVSLGPEKSVEGQNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNLFLTNLDN 1200
Query: 1201 LHENNTHNQEKKIQEEIEKKETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQNVEGSYD 1260
LHENNTHNQEKKIQEEIEKKETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQNVEGSYD
Sbjct: 1201 LHENNTHNQEKKIQEEIEKKETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQNVEGSYD 1260
Query: 1261 GAYAPVLQDFRSLNDSTNRTKKHTAHFSKKGEEENLEGLGNQTKQIVEKYACTTRISPNT 1320
GAYAPVLQDFRSLNDSTNRTKKHTAHFSKKGEEENLEGLGNQTKQIVEKYACTTRISPNT
Sbjct: 1261 GAYAPVLQDFRSLNDSTNRTKKHTAHFSKKGEEENLEGLGNQTKQIVEKYACTTRISPNT 1320
Query: 1321 SQQNFVTQRSKRALKQFRLPLEETELEKRIIVDDTSTQWSKNMKHLTPSTLTQIDYNEKE 1380
SQQNFVTQRSKRALKQFRLPLEETELEKRIIVDDTSTQWSKNMKHLTPSTLTQIDYNEKE
Sbjct: 1321 SQQNFVTQRSKRALKQFRLPLEETELEKRIIVDDTSTQWSKNMKHLTPSTLTQIDYNEKE 1380
Query: 1381 KGAITQSPLSDCLTRSHSIPQANRSPLPIAKVSSFPSIRPIYLTRVLFQDNSSHLPAASY 1440
KGAITQSPLSDCLTRSHSIPQANRSPLPIAKVSSFPSIRPIYLTRVLFQDNSSHLPAASY
Sbjct: 1381 KGAITQSPLSDCLTRSHSIPQANRSPLPIAKVSSFPSIRPIYLTRVLFQDNSSHLPAASY 1440
Query: 1441 RKKDSGVQESSHFLQGAKKNNLSLAILTLEMTGDQREVGSLGTSATNSVTYKKVENTVLP 1500
RKKDSGVQESSHFLQGAKKNNLSLAILTLEMTGDQREVGSLGTSATNSVTYKKVENTVLP
Sbjct: 1441 RKKDSGVQESSHFLQGAKKNNLSLAILTLEMTGDQREVGSLGTSATNSVTYKKVENTVLP 1500
Query: 1501 KPDLPKTSGKVELLPKVHIYQKDLFPTETSNGSPGHLDLVEGSLLQGTEGAIKWNEANRP 1560
KPDLPKTSGKVELLPKVHIYQKDLFPTETSNGSPGHLDLVEGSLLQGTEGAIKWNEANRP
Sbjct: 1501 KPDLPKTSGKVELLPKVHIYQKDLFPTETSNGSPGHLDLVEGSLLQGTEGAIKWNEANRP 1560
Query: 1561 GKVPFLRVATESSAKTPSKLLDPLAWDNHYGTQIPKEEWKSQEKSPEKTAFKKKDTILSL 1620
GKVPFLRVATESSAKTPSKLLDPLAWDNHYGTQIPKEEWKSQEKSPEKTAFKKKDTILSL
Sbjct: 1561 GKVPFLRVATESSAKTPSKLLDPLAWDNHYGTQIPKEEWKSQEKSPEKTAFKKKDTILSL 1620
Query: 1621 NACESNHAIAAINEGQNKPEIEVTWAKQGRTERLCSQNPPVLKRHQREITRTTLQSDQEE 1680
NACESNHAIAAINEGQNKPEIEVTWAKQGRTERLCSQNPPVLKRHQREITRTTLQSDQEE
Sbjct: 1621 NACESNHAIAAINEGQNKPEIEVTWAKQGRTERLCSQNPPVLKRHQREITRTTLQSDQEE 1680
Query: 1681 IDYDDTISVEMKKEDFDIYDEDENQSPRSFQKKTRHYFIAAVERLWDYGMSSSPHVLRNR 1740
IDYDDTISVEMKKEDFDIYDEDENQSPRSFQKKTRHYFIAAVERLWDYGMSSSPHVLRNR
Sbjct: 1681 IDYDDTISVEMKKEDFDIYDEDENQSPRSFQKKTRHYFIAAVERLWDYGMSSSPHVLRNR 1740
Query: 1741 AQSGSVPQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASR 1800
AQSGSVPQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASR
Sbjct: 1741 AQSGSVPQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASR 1800
Query: 1801 PYSFYSSLISYEEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDV 1860
PYSFYSSLISYEEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDV
Sbjct: 1801 PYSFYSSLISYEEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDV 1860
Query: 1861 DLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRA 1920
DLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRA
Sbjct: 1861 DLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRA 1920
Query: 1921 PCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGH 1980
PCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGH
Sbjct: 1921 PCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGH 1980
Query: 1981 VFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKC 2040
VFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKC
Sbjct: 1981 VFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKC 2040
Query: 2041 QTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMII 2100
QTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMII
Sbjct: 2041 QTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMII 2100
Query: 2101 HGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFN 2160
HGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFN
Sbjct: 2101 HGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFN 2160
Query: 2161 PPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFA 2220
PPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFA
Sbjct: 2161 PPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFA 2220
Query: 2221 TWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFL 2280
TWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFL
Sbjct: 2221 TWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFL 2280
Query: 2281 ISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRM 2340
ISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRM
Sbjct: 2281 ISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRM 2340
Query: 2341 EVLGCEAQDLY 2351
EVLGCEAQDLY
Sbjct: 2341 EVLGCEAQDLY 2351
>gi|105990535 coagulation factor V precursor [Homo sapiens]
Length = 2224
Score = 532 bits (1371), Expect = e-150
Identities = 288/699 (41%), Positives = 416/699 (59%), Gaps = 38/699 (5%)
Query: 1675 QSDQEEIDY---DDTISVEMKKEDFDIYDEDENQS--PRSFQKKTRHYFIAAVERLWDYG 1729
+ D EIDY DD +++ D D + RS R+Y+IAA E WDY
Sbjct: 1535 EDDYAEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDY- 1593
Query: 1730 MSSSPHVLRNR--AQSGSVPQ---FKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRA 1784
S V R S +P+ +KKVVF+++ D +FT+ RGE EHLG+LGP IRA
Sbjct: 1594 ---SEFVQRETDIEDSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRA 1650
Query: 1785 EVEDNIMVTFRNQASRPYSFYSSLISYE--------EDQRQGAEPRKNFVKPNETKTYFW 1836
EV+D I V F+N ASRPYS ++ +SYE ED N V+PN + TY W
Sbjct: 1651 EVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVW 1710
Query: 1837 KVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFA 1896
P C+AWAY+S V+ EKD+HSGLIGPLL+C L+ + ++EF
Sbjct: 1711 HATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFV 1770
Query: 1897 LFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQD 1956
L F FDE KSWY+ + + R + K+++ FHAING I +LPGL M +
Sbjct: 1771 LLFMTFDEKKSWYYEKKSRSSWR------LTSSEMKKSHEFHAINGMIY-SLPGLKMYEQ 1823
Query: 1957 QRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWR 2016
+ +R +LL++G +++IH +HF G +++++ ++ L PG F+T+EM SK G W
Sbjct: 1824 EWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWL 1883
Query: 2017 VECLIGEHLHAGMSTLFLVYSNKCQTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSG 2076
+ +GE+ AGM T FL+ C+ P+G+++G I D QI AS G W P+LARL+ G
Sbjct: 1884 LNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGG 1943
Query: 2077 SINAWSTKEPFS------WIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKK 2130
S NAWS ++ + WI+VD+ +II GI+TQGA+ S Y ++F + YS +
Sbjct: 1944 SYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQIN 2003
Query: 2131 WQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDL 2190
WQ ++GNST +M F GN D+S IK N F+PPI+ARYIR+ PT R TLR+EL GC++
Sbjct: 2004 WQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEV 2063
Query: 2191 NSCSMPLGMESKAISDAQITASSYFTNMFAT-WSPSKARLHLQGRSNAWRPQVNNPKEWL 2249
N CS PLGME+ I + QITASS+ + + W P +ARL+ QGR NAW+ + NN K+WL
Sbjct: 2064 NGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWL 2123
Query: 2250 QVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV--KVFQGNQD 2307
++D K K+T + TQG KSL + MYVK + I S+ G +W + + K+F+GN +
Sbjct: 2124 EIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN 2183
Query: 2308 SFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE 2346
+ V N +PP+++R++R+ P++W IALR+E+ GC+
Sbjct: 2184 TKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCD 2222
Score = 499 bits (1284), Expect = e-140
Identities = 278/730 (38%), Positives = 404/730 (55%), Gaps = 75/730 (10%)
Query: 22 RRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVV-YKKTLFVEFTDHLFNI 80
R++Y+ A +SW Y P + N SV +KK ++ E+ + F
Sbjct: 32 RQFYVAAQGISWSYRPE---------------PTNSSLNLSVTSFKKIVYREYEPY-FKK 75
Query: 81 AKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQR 140
KP+ GLLGPT+ AEV D + + KN A P+S+H G+ Y K SEGA Y D T
Sbjct: 76 EKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASYLDHTFPA 135
Query: 141 EKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCRE 200
EK DD V PG +TY W + +++GP DP CLT+ Y SH +L++D NSGLIG LL+C++
Sbjct: 136 EKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKK 195
Query: 201 GSLAKEKTQTLH--KFILLFAVFDEGKSWHSETKNSLMQDRDAASARAWPKMHTVNGYVN 258
G+L + TQ + +LLFAVFDE KSW + M+TVNGYVN
Sbjct: 196 GTLTEGGTQKTFDKQIVLLFAVFDESKSWSQSSS----------------LMYTVNGYVN 239
Query: 259 RSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTL 318
++P + C + WH++GM + PE+ SI G +H+ +++ + T TA
Sbjct: 240 GTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMT 299
Query: 319 LMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEAEDYDDDLTDSEMDVVR 378
+ G++++ H GM+AY+ + +CP++ + K E
Sbjct: 300 VGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQ---------------- 343
Query: 379 FDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRI 438
++H K W ++IAAEE WDYAP++ A D+ Y+SQ+L+N +I
Sbjct: 344 ----------------RRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQI 387
Query: 439 GRKYKKVRFMAYTDETFK--TREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYP 496
G+ YKKV + Y DE+F T E GILGP++ +V DTL I+FKN ASRPY+IYP
Sbjct: 388 GKHYKKVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYP 447
Query: 497 HGIT--DVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSS 554
HG+T + G + + PGE + YKW + D PT++D +CLTR Y S
Sbjct: 448 HGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYS 507
Query: 555 FVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFL 614
V++ RD+ASGLIG LLIC S+D+RG Q +D +F+VFDEN+SWYL +NI +F
Sbjct: 508 DVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFC 567
Query: 615 PNPAGVQLEDPEFQASNIMHSINGYVFDSL-QLSVCLHEVAYWYILSIGAQTDFLSVFFS 673
NP V+ +DP+F SNIM +INGYV +S+ L C + W+ S+G Q + L++ F+
Sbjct: 568 ENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFT 627
Query: 674 GYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCDKN 733
G++F + +EDTLTLFP GE+V ++M+N G W+L NS R++ + + C
Sbjct: 628 GHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKC--- 684
Query: 734 TGDYYEDSYE 743
D EDSYE
Sbjct: 685 IPDDDEDSYE 694
Score = 199 bits (506), Expect = 3e-50
Identities = 114/327 (34%), Positives = 179/327 (54%), Gaps = 17/327 (5%)
Query: 22 RRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVVYKKTLFVEFTDHLFNIA 81
R YY+ A E+SWDY S+ + D +P+ YKK +F ++ D F
Sbjct: 1580 RNYYIAAEEISWDY--SEFVQRETDIEDSDDIPED------TTYKKVVFRKYLDSTFTKR 1631
Query: 82 KPRPPW---MGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTS 138
PR + +G+LGP I+AEV D + + KN+AS P SLHA G+SY K+SEG Y+D +
Sbjct: 1632 DPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSP 1691
Query: 139 QREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVC 198
+ KED+ V P S+TYVW + +GP + C ++Y S V+ KD++SGLIG LL+C
Sbjct: 1692 EWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLIC 1751
Query: 199 REGSLAKEKT--QTLHKFILLFAVFDEGKSWHSETKNSLMQDRDAASARAWPKMHTVNGY 256
++G L K+ + +F+LLF FDE KSW+ E K+ ++ + + H +NG
Sbjct: 1752 QKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMKKSHEFHAINGM 1811
Query: 257 VNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPI---TFL 313
+ SLPGL ++ V H++ +G + ++H + G T L ++Q L + P+ +F
Sbjct: 1812 I-YSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFK 1870
Query: 314 TAQTLLMDLGQFLLFCHISSHQHDGME 340
T + G +LL + +Q GM+
Sbjct: 1871 TLEMKASKPGWWLLNTEVGENQRAGMQ 1897
Score = 188 bits (478), Expect = 5e-47
Identities = 108/320 (33%), Positives = 166/320 (51%), Gaps = 23/320 (7%)
Query: 1713 KTRHYFIAAVERLWDYG---------MSSSPHVLRNRAQSGSVPQFKKVVFQEFTDGSFT 1763
K YFIAA E +WDY S H+ Q G +KKV++ ++ D SFT
Sbjct: 348 KRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGK--HYKKVMYTQYEDESFT 405
Query: 1764 QPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLIS---YEEDQRQGAE 1820
+ + E G+LGP IRA+V D + + F+N ASRPYS Y ++ YE++
Sbjct: 406 KHTVNPNMKED-GILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFT 464
Query: 1821 PRKN-----FVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLL 1875
+N V+P ET TY W + PT+++ C Y+SDVD+ +D+ SGLIG LL
Sbjct: 465 SGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLL 524
Query: 1876 VCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENY 1935
+C + +L+ ++ E F +FDE KSWY +N+ + C P ++ +DP F E+
Sbjct: 525 ICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESN 584
Query: 1936 RFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALY 1995
INGY+ +++ L D ++W+ S+G+ I +IHF+GH F K+ E +
Sbjct: 585 IMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTL--- 641
Query: 1996 NLYPGVFETVEMLPSKAGIW 2015
L+P E+V + G W
Sbjct: 642 TLFPMRGESVTVTMDNVGTW 661
Score = 162 bits (410), Expect = 4e-39
Identities = 118/384 (30%), Positives = 170/384 (44%), Gaps = 38/384 (9%)
Query: 360 EEAEDYDDDLTDSEMDVVRFDD------------DNSPSFIQIRSVAKKHPKTWVHYIAA 407
EE + +DD +E+D V +DD P I + + +YIAA
Sbjct: 1529 EEVQSSEDDY--AEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAA 1586
Query: 408 EEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREA---IQHE 464
EE WDY+ V D + YKKV F Y D TF R+ +
Sbjct: 1587 EEISWDYSEFVQRETDIEDSDDIPED------TTYKKVVFRKYLDSTFTKRDPRGEYEEH 1640
Query: 465 SGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRP----LYSRRLPKGVKHLKDF 520
GILGP++ EV D + + FKN ASRPY+++ HG++ + Y P+ K +D
Sbjct: 1641 LGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFK--EDN 1698
Query: 521 PILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQ 580
+ P + Y W T GP C Y S VN E+D+ SGLIGPLLIC K + +
Sbjct: 1699 AVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHK 1758
Query: 581 RGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYV 640
N M + V+LF FDE +SWY + + + +L E + S+ H+ING +
Sbjct: 1759 DSNMPMDMREFVLLFMTFDEKKSWYYEKK------SRSSWRLTSSEMKKSHEFHAINGMI 1812
Query: 641 FDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTF---KHKMVYEDTLTLFPFSGETV 697
+ L + E ++L+IG D V F G T +K L P S +T+
Sbjct: 1813 YSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTL 1872
Query: 698 FMSMENPGLWILGCHNSDFRNRGM 721
M PG W+L + + GM
Sbjct: 1873 EMKASKPGWWLLNTEVGENQRAGM 1896
Score = 161 bits (408), Expect = 6e-39
Identities = 121/424 (28%), Positives = 198/424 (46%), Gaps = 45/424 (10%)
Query: 24 YYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVVYKKTLFVEFTDHLF--NIA 81
Y++ A E+ WDY + + +D ++ + +F YKK ++ ++ D F +
Sbjct: 352 YFIAAEEVIWDY--APVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTV 409
Query: 82 KPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQRE 141
P G+LGP I+A+V DT+ I KNMAS P S++ GV++ + + +
Sbjct: 410 NPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNN 469
Query: 142 KEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCREG 201
V PG ++TY W +L+ + P +D CLT Y S VD+++D+ SGLIG LL+C+
Sbjct: 470 TMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSR 529
Query: 202 SLAKEKTQTLHKF--ILLFAVFDEGKSWHSETKNSLMQDRDAASARAWPK------MHTV 253
SL + Q +FAVFDE KSW+ E + + R PK M T+
Sbjct: 530 SLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTI 589
Query: 254 NGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFL 313
NGYV S+ L C +V WH +GT E+ +I GH+F+ + +L + P+
Sbjct: 590 NGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGE 649
Query: 314 TAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEAEDYDDDLTDSE 373
+ + ++G ++L ++S P +LR+K + DDD E
Sbjct: 650 SVTVTMDNVGTWML---------------TSMNSSPRSKKLRLKFRDVKCIPDDDEDSYE 694
Query: 374 MDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEE----DWDYA-PLVLAPDDRSYKS 428
+ F+ S + + K H + + E+E D+DY L A RS+++
Sbjct: 695 I----FEPPES----TVMATRKMHDR-----LEPEDEESDADYDYQNRLAAALGIRSFRN 741
Query: 429 QYLN 432
LN
Sbjct: 742 SSLN 745
Score = 153 bits (386), Expect = 2e-36
Identities = 97/325 (29%), Positives = 150/325 (46%), Gaps = 46/325 (14%)
Query: 1715 RHYFIAAVERLWDYGMSSSPHVLRNRAQSGSVPQFKKVVFQEFTDGSFTQPLYRGELNEH 1774
R +++AA W Y + N + + SV FKK+V++E+ +P ++ E +
Sbjct: 32 RQFYVAAQGISWSYRPEPT-----NSSLNLSVTSFKKIVYREY------EPYFKKEKPQS 80
Query: 1775 L--GLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEE--------DQRQGAEPRKN 1824
GLLGP + AEV D I V F+N+A +P S + I Y + D AE +
Sbjct: 81 TISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDD 140
Query: 1825 FVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHTNTLNP 1884
V P TY W + PT D+ C Y+S +L +D +SGLIGPLL+C TL
Sbjct: 141 AVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTE 200
Query: 1885 AHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENYRFHAINGYI 1944
++ ++ L F +FDE+KSW + ++ + +NGY+
Sbjct: 201 GGTQKTFDKQIVLLFAVFDESKSWSQSSSL----------------------MYTVNGYV 238
Query: 1945 MDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLYPGVFET 2004
T+P + + I W+LL M S + SIHF+G V ++ +K++ L T
Sbjct: 239 NGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVL---EQNHHKVSAITLVSATSTT 295
Query: 2005 VEMLPSKAGIWRVECLIGEHLHAGM 2029
M G W + L +HL AGM
Sbjct: 296 ANMTVGPEGKWIISSLTPKHLQAGM 320
Score = 120 bits (300), Expect = 2e-26
Identities = 67/162 (41%), Positives = 92/162 (56%), Gaps = 11/162 (6%)
Query: 2038 NKCQTPLGMASGHIRDFQITAS-------GQYGQWAPKLARLHYSGSINAWSTKEPFS-- 2088
N C TPLGM +G I + QITAS G Y W P ARL+ G +NAW K +
Sbjct: 2064 NGCSTPLGMENGKIENKQITASSFKKSWWGDY--WEPFRARLNAQGRVNAWQAKANNNKQ 2121
Query: 2089 WIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGN 2148
W+++DLL I I TQG + S +Y+ + I YS G +W+ YR S+ +F GN
Sbjct: 2122 WLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGN 2181
Query: 2149 VDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDL 2190
++ G N FNPPII+R+IR+ P ++ LR+EL GCD+
Sbjct: 2182 TNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
>gi|148886707 hephaestin-like 1 [Homo sapiens]
Length = 1159
Score = 471 bits (1212), Expect = e-132
Identities = 282/775 (36%), Positives = 403/775 (52%), Gaps = 84/775 (10%)
Query: 10 FLCLLRFCFSATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSF----PFNTSVVY 65
FL L + TR YY+G VE W+Y+ + + ++ F P +Y
Sbjct: 15 FLGLSGLVGTVTRTYYIGIVEEYWNYVPQGKNVITGKSFTEDKLATLFLERGPNRIGSIY 74
Query: 66 KKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYW 125
KK ++ FTD ++I P+PPW+G LGP ++AEV D +VI LKN AS P SLH GV Y
Sbjct: 75 KKAVYRRFTDGTYSIEIPKPPWLGFLGPILRAEVGDVIVIHLKNFASRPYSLHPHGVFYN 134
Query: 126 KASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVK 185
K SEGA Y D TS R K DD V PG ++TYVW V +E P +D CLT+ Y SH+D K
Sbjct: 135 KDSEGALYPDGTSGRNKNDDMVPPGKNYTYVWPVREEYAPTPADANCLTWVYHSHIDAPK 194
Query: 186 DLNSGLIGALLVCREGSLAK---EKTQTLHKFILLFAVFDEGKSW-------HSETKNSL 235
D+ SGLIG LLVC+EG L + + +F+++F + DE +SW H T
Sbjct: 195 DICSGLIGPLLVCKEGILNRYSGTRNDVDREFVIMFTLVDENQSWYLNENIKHFCTNPDS 254
Query: 236 MQDRDAASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTF 295
+ +DA R+ KMH +NGY+ + P C +SV WH+ GMG ++HSI+ G+TF
Sbjct: 255 VDKKDAVFQRS-NKMHALNGYLFGNFPEPDMCVGESVSWHLFGMGNEIDIHSIYFYGNTF 313
Query: 296 LVRNHRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEE---P 352
+ R HR + + P TFLT + + + G++++ C +S H GM VD+C + P
Sbjct: 314 ISRGHRTDVVNLFPATFLTTEMIAENPGKWMITCQVSDHLQAGMLGQYNVDNCKSDIFYP 373
Query: 353 QLRMKNNEEAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDW 412
+++ + ++IAAE+ W
Sbjct: 374 KMKGQQRR------------------------------------------YFIAAEKILW 391
Query: 413 DYAPL-------VLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHES 465
DYAP + S Y G RIG KY KVR+ + D TF R+ + E
Sbjct: 392 DYAPQGYNKFSGLPLNASGSDSDLYFTQGDNRIGGKYWKVRYTEFVDATFTKRKRLSAEE 451
Query: 466 ---GILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGI-----TDVRPLYSRRLPKGVKHL 517
GILGP++ EVGDTLL+ F N+A + Y+I PHG+ +D P + G H+
Sbjct: 452 AHLGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKASDAAPNLDGFVKPGA-HV 510
Query: 518 KDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKES 577
K PGE F YKWTV PT DP CLT Y S V+ +D +SGL+GPLL+C K
Sbjct: 511 K-----PGETFTYKWTVPESVSPTAGDPPCLTYLYFSAVDPIKDTSSGLVGPLLVCKKGV 565
Query: 578 VDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSIN 637
++ G Q DK +LF+VFDEN S Y ENIQ+F+ +P + ED EF SN MH++N
Sbjct: 566 LNADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKFIWHPFSIDKEDKEFVKSNRMHAVN 625
Query: 638 GYVFDSLQ-LSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGET 696
GY++ + L++C + W+++ +G TD + F G T + + D+L LFP T
Sbjct: 626 GYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQGNTIHLRGTHRDSLALFPHMATT 685
Query: 697 VFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCDKNTGDYYEDSYEDISAYLLS 751
FM ++ G++ + C +RGM + +VSSCD D E Y I + ++
Sbjct: 686 AFMQPDHAGIFRVFCATMPHLSRGMGQIYEVSSCDNR--DPSEQRYGMIRTFYIA 738
Score = 360 bits (925), Expect = 7e-99
Identities = 248/737 (33%), Positives = 361/737 (48%), Gaps = 94/737 (12%)
Query: 22 RRYYLGAVELSWDYMQSDLGE---LPVDARFPPRVPKSFPFNTSV--VYKKTLFVEFTDH 76
RRY++ A ++ WDY + LP++A + + Y K + EF D
Sbjct: 380 RRYFIAAEKILWDYAPQGYNKFSGLPLNASGSDSDLYFTQGDNRIGGKYWKVRYTEFVDA 439
Query: 77 LFNIAK---PRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEY 133
F K +G+LGP I+AEV DT+++T N A S+ GV Y KAS+ A
Sbjct: 440 TFTKRKRLSAEEAHLGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKASDAAPN 499
Query: 134 DDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIG 193
D K V PG + TY W V + P A DP CLTY Y S VD +KD +SGL+G
Sbjct: 500 LDGFV---KPGAHVKPGETFTYKWTVPESVSPTAGDPPCLTYLYFSAVDPIKDTSSGLVG 556
Query: 194 ALLVCREGSLAKEKTQTL--HKFILLFAVFDEGKS-----------WHSETKNSLMQDRD 240
LLVC++G L + TQ +F LLF VFDE S WH + + +D++
Sbjct: 557 PLLVCKKGVLNADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKFIWHPFSIDK--EDKE 614
Query: 241 AASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH 300
+ +MH VNGY+ + PGL C R V WH+IG+GT ++H I +G+T +R
Sbjct: 615 FVKSN---RMHAVNGYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQGNTIHLRGT 671
Query: 301 RQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNE 360
+ SL + P TA G F +FC H GM +V SC
Sbjct: 672 HRDSLALFPHMATTAFMQPDHAGIFRVFCATMPHLSRGMGQIYEVSSC------------ 719
Query: 361 EAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPL--- 417
D+ PS +++ YIAAEE +WDYAP
Sbjct: 720 --------------------DNRDPS-------EQRYGMIRTFYIAAEEVEWDYAPNKNW 752
Query: 418 ------VLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETF---KTREAIQHESGIL 468
V A +R + ++N IG +YKKV + YTD F K R + +L
Sbjct: 753 EFEKQHVDARGER-HGDIFMNRTENWIGSQYKKVVYREYTDGEFVEIKARPPREEHLELL 811
Query: 469 GPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIF 528
GP+++ EVG+T+LIIFKN+ASRPY+I G+ ++ ++P PGE+
Sbjct: 812 GPMIHAEVGNTVLIIFKNKASRPYSISAQGVEEMDSGKQFQVPM---------TKPGEVK 862
Query: 529 KYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSD 588
Y+W + GP SDP C+ Y S VN +D SGL+GPL+ C K ++++G + D
Sbjct: 863 TYRWNIPKRSGPGPSDPNCIPWVYYSTVNFVKDTYSGLMGPLITCRKGVLNEKGRRSDVD 922
Query: 589 KRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQ-LS 647
+LF VF+EN SWYL +NI+++L +F+ SN MH+ING +F +L L
Sbjct: 923 YEFALLFLVFNENESWYLDDNIKKYLNKDPRDFKRTDDFEESNRMHAINGKIFGNLHGLI 982
Query: 648 VCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHKM---VYEDTLTLFPFSGETVFMSMENP 704
+ + WY+L IG++ D ++ + +F K+ ED LFP + +T+ + ++P
Sbjct: 983 MNEDTMTNWYLLGIGSEVDIHTIHYHAESFLFKIDKSYREDVYDLFPGTFQTIELFADHP 1042
Query: 705 GLWILGCHNSDFRNRGM 721
G W+L CH SD + GM
Sbjct: 1043 GTWLLHCHVSDHIHAGM 1059
Score = 242 bits (618), Expect = 3e-63
Identities = 122/339 (35%), Positives = 182/339 (53%), Gaps = 18/339 (5%)
Query: 1715 RHYFIAAVERLWDYGMSSS---------------PHVLRNRAQSGSVPQFKKVVFQEFTD 1759
R ++IAA E WDY + + + NR ++ Q+KKVV++E+TD
Sbjct: 733 RTFYIAAEEVEWDYAPNKNWEFEKQHVDARGERHGDIFMNRTENWIGSQYKKVVYREYTD 792
Query: 1760 GSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQRQGA 1819
G F + R EHL LLGP I AEV + +++ F+N+ASRPYS + + E+ G
Sbjct: 793 GEFVEIKARPPREEHLELLGPMIHAEVGNTVLIIFKNKASRPYSISAQGV---EEMDSGK 849
Query: 1820 EPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHT 1879
+ + KP E KTY W + P + +C W Y+S V+ KD +SGL+GPL+ C
Sbjct: 850 QFQVPMTKPGEVKTYRWNIPKRSGPGPSDPNCIPWVYYSTVNFVKDTYSGLMGPLITCRK 909
Query: 1880 NTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENYRFHA 1939
LN R EFAL F +F+E +SWY +N+++ F+E+ R HA
Sbjct: 910 GVLNEKGRRSDVDYEFALLFLVFNENESWYLDDNIKKYLNKDPRDFKRTDDFEESNRMHA 969
Query: 1940 INGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLYP 1999
ING I L GL+M +D WYLL +GS +IH+IH+ F + + Y+ +Y+L+P
Sbjct: 970 INGKIFGNLHGLIMNEDTMTNWYLLGIGSEVDIHTIHYHAESFLFKIDKSYREDVYDLFP 1029
Query: 2000 GVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSN 2038
G F+T+E+ G W + C + +H+HAGM T + V N
Sbjct: 1030 GTFQTIELFADHPGTWLLHCHVSDHIHAGMETTYTVLRN 1068
Score = 219 bits (559), Expect = 2e-56
Identities = 129/379 (34%), Positives = 191/379 (50%), Gaps = 32/379 (8%)
Query: 1714 TRHYFIAAVERLWDY---------GMSSSPHVL------RNRAQSGSVPQFKKVVFQEFT 1758
TR Y+I VE W+Y G S + L R + GS+ +KK V++ FT
Sbjct: 26 TRTYYIGIVEEYWNYVPQGKNVITGKSFTEDKLATLFLERGPNRIGSI--YKKAVYRRFT 83
Query: 1759 DGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQR-- 1816
DG+++ + + LG LGP +RAEV D I++ +N ASRPYS + + Y +D
Sbjct: 84 DGTYSIEIPKPPW---LGFLGPILRAEVGDVIVIHLKNFASRPYSLHPHGVFYNKDSEGA 140
Query: 1817 ------QGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGL 1870
G + V P + TY W V+ APT + +C W Y S +D KD+ SGL
Sbjct: 141 LYPDGTSGRNKNDDMVPPGKNYTYVWPVREEYAPTPADANCLTWVYHSHIDAPKDICSGL 200
Query: 1871 IGPLLVCHTNTLNPAHGRQVTV-QEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDP 1929
IGPLLVC LN G + V +EF + FT+ DE +SWY EN++ C P ++ +D
Sbjct: 201 IGPLLVCKEGILNRYSGTRNDVDREFVIMFTLVDENQSWYLNENIKHFCTNPDSVDKKDA 260
Query: 1930 TFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEE 1989
F+ + + HA+NGY+ P M + + W+L MG+ +IHSI+F G+ F R
Sbjct: 261 VFQRSNKMHALNGYLFGNFPEPDMCVGESVSWHLFGMGNEIDIHSIYFYGNTFISR---G 317
Query: 1990 YKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTPLGMASG 2049
++ + NL+P F T EM+ G W + C + +HL AGM + V + K G
Sbjct: 318 HRTDVVNLFPATFLTTEMIAENPGKWMITCQVSDHLQAGMLGQYNVDNCKSDIFYPKMKG 377
Query: 2050 HIRDFQITASGQYGQWAPK 2068
R + I A +AP+
Sbjct: 378 QQRRYFIAAEKILWDYAPQ 396
Score = 217 bits (553), Expect = 9e-56
Identities = 142/393 (36%), Positives = 198/393 (50%), Gaps = 29/393 (7%)
Query: 1699 YDEDENQSPRSFQK---KTRHYFIAAVERLWDY---GMSSSPHVLRNRAQSGSVPQFK-- 1750
Y+ D +S + K + R YFIAA + LWDY G + + N + S S F
Sbjct: 361 YNVDNCKSDIFYPKMKGQQRRYFIAAEKILWDYAPQGYNKFSGLPLNASGSDSDLYFTQG 420
Query: 1751 ---------KVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRP 1801
KV + EF D +FT+ HLG+LGP I+AEV D ++VTF N+A +
Sbjct: 421 DNRIGGKYWKVRYTEFVDATFTKRKRLSAEEAHLGILGPVIKAEVGDTLLVTFANKADKV 480
Query: 1802 YSFYSSLISYEEDQRQGAEPRKN-------FVKPNETKTYFWKVQHHMAPTKDEFDCKAW 1854
YS + Y D+ A P + VKP ET TY W V ++PT + C +
Sbjct: 481 YSILPHGVIY--DKASDAAPNLDGFVKPGAHVKPGETFTYKWTVPESVSPTAGDPPCLTY 538
Query: 1855 AYFSDVDLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENM 1914
YFS VD KD SGL+GPLLVC LN ++ +EF L FT+FDE S YF EN+
Sbjct: 539 LYFSAVDPIKDTSSGLVGPLLVCKKGVLNADGTQKGIDKEFYLLFTVFDENLSRYFDENI 598
Query: 1915 ERNCRAPCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHS 1974
++ P +I ED F ++ R HA+NGY+ PGL M + R+ W+L+ +G++ ++H
Sbjct: 599 QKFIWHPFSIDKEDKEFVKSNRMHAVNGYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHG 658
Query: 1975 IHFSGHVFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFL 2034
I F G+ +R +A L+P + T M P AGI+RV C HL GM ++
Sbjct: 659 IVFQGNTIHLRGTHRDSLA---LFPHMATTAFMQPDHAGIFRVFCATMPHLSRGMGQIYE 715
Query: 2035 VYSNKCQTPLGMASGHIRDFQITASGQYGQWAP 2067
V S + P G IR F I A +AP
Sbjct: 716 VSSCDNRDPSEQRYGMIRTFYIAAEEVEWDYAP 748
Score = 172 bits (436), Expect = 3e-42
Identities = 115/344 (33%), Positives = 175/344 (50%), Gaps = 33/344 (9%)
Query: 18 FSATRRYYLGAVELSWDYMQSDLGELP---VDARFPPRVPKSFPFNTS----VVYKKTLF 70
+ R +Y+ A E+ WDY + E VDAR R F T YKK ++
Sbjct: 729 YGMIRTFYIAAEEVEWDYAPNKNWEFEKQHVDAR-GERHGDIFMNRTENWIGSQYKKVVY 787
Query: 71 VEFTDHLFNIAKPRPP---WMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKA 127
E+TD F K RPP + LLGP I AEV +TV+I KN AS P S+ A GV
Sbjct: 788 REYTDGEFVEIKARPPREEHLELLGPMIHAEVGNTVLIIFKNKASRPYSISAQGV----- 842
Query: 128 SEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDL 187
++ S ++ + PG TY W + K +GP SDP C+ + Y S V+ VKD
Sbjct: 843 ------EEMDSGKQFQVPMTKPGEVKTYRWNIPKRSGPGPSDPNCIPWVYYSTVNFVKDT 896
Query: 188 NSGLIGALLVCREGSLAKE--KTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRDAASAR 245
SGL+G L+ CR+G L ++ ++ ++F LLF VF+E +SW+ + ++D +
Sbjct: 897 YSGLMGPLITCRKGVLNEKGRRSDVDYEFALLFLVFNENESWYLDDNIKKYLNKDPRDFK 956
Query: 246 AWP------KMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLV-- 297
+MH +NG + +L GLI W+++G+G+ ++H+I +FL
Sbjct: 957 RTDDFEESNRMHAINGKIFGNLHGLIMNEDTMTNWYLLGIGSEVDIHTIHYHAESFLFKI 1016
Query: 298 -RNHRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGME 340
+++R+ ++ P TF T + G +LL CH+S H H GME
Sbjct: 1017 DKSYREDVYDLFPGTFQTIELFADHPGTWLLHCHVSDHIHAGME 1060
>gi|10518506 coagulation factor VIII isoform b precursor [Homo
sapiens]
Length = 216
Score = 429 bits (1104), Expect = e-119
Identities = 208/208 (100%), Positives = 208/208 (100%)
Query: 2144 VFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKA 2203
VFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKA
Sbjct: 9 VFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKA 68
Query: 2204 ISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVT 2263
ISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVT
Sbjct: 69 ISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVT 128
Query: 2264 TQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTR 2323
TQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTR
Sbjct: 129 TQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTR 188
Query: 2324 YLRIHPQSWVHQIALRMEVLGCEAQDLY 2351
YLRIHPQSWVHQIALRMEVLGCEAQDLY
Sbjct: 189 YLRIHPQSWVHQIALRMEVLGCEAQDLY 216
Score = 121 bits (304), Expect = 7e-27
Identities = 63/158 (39%), Positives = 88/158 (55%), Gaps = 8/158 (5%)
Query: 2038 NKCQTPLGMASGHIRDFQITASG----QYGQWAPKLARLHYSGSINAW--STKEPFSWIK 2091
N C PLGM S I D QITAS + W+P ARLH G NAW P W++
Sbjct: 56 NSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQ 115
Query: 2092 VDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDS 2151
VD M + G+ TQG + +S+Y+ +F+I S DG +W + N G + VF GN DS
Sbjct: 116 VDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQN--GKVKVFQGNQDS 173
Query: 2152 SGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCD 2189
N +PP++ RY+R+HP + + LRME++GC+
Sbjct: 174 FTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE 211
Score = 47.8 bits (112), Expect = 1e-04
Identities = 21/47 (44%), Positives = 31/47 (65%)
Query: 2300 KVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE 2346
KVF GN DS N +PP++ RY+R+HP + + LRME++GC+
Sbjct: 8 KVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCD 54
>gi|4557485 ceruloplasmin precursor [Homo sapiens]
Length = 1065
Score = 426 bits (1096), Expect = e-118
Identities = 261/766 (34%), Positives = 391/766 (51%), Gaps = 81/766 (10%)
Query: 5 LSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDLGE---LPVDARFPPRVPKSFPFNT 61
L FLC ++ + YY+G +E +WDY SD GE + VD ++ P
Sbjct: 6 LGIFLFLCSTP-AWAKEKHYYIGIIETTWDY-ASDHGEKKLISVDTEHSNIYLQNGPDRI 63
Query: 62 SVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVG 121
+YKK L++++TD F +P W+G LGP I+AE D V + LKN+AS P + H+ G
Sbjct: 64 GRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHG 123
Query: 122 VSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHV 181
++Y+K EGA Y D T+ ++ DDKV+PG +TY+ +E P D C+T Y SH+
Sbjct: 124 ITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHI 183
Query: 182 DLVKDLNSGLIGALLVCREGSLAKEKTQTL-HKFILLFAVFDEGKSWHSE------TKNS 234
D KD+ SGLIG L++C++ SL KEK + + +F+++F+V DE SW+ E
Sbjct: 184 DAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEP 243
Query: 235 LMQDRDAASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHT 294
D+D + +M++VNGY SLPGL C V W++ GMG +VH+ F G
Sbjct: 244 EKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQA 303
Query: 295 FLVRNHRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQL 354
+N+R ++ + P T A + + G+++L C +H G++A+ +V C
Sbjct: 304 LTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQEC------ 357
Query: 355 RMKNNEEAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDY 414
N ++D IR +H +YIAAEE W+Y
Sbjct: 358 ---NKSSSKD------------------------NIRGKHVRH-----YYIAAEEIIWNY 385
Query: 415 APL---------VLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETF---KTREAIQ 462
AP + AP S + + G RIG YKK+ + YTD +F K R +
Sbjct: 386 APSGIDIFTKENLTAPGSDS--AVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEE 443
Query: 463 HESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGI--------TDVRPLY---SRRLP 511
GILGP+++ EVGDT+ + F N+ + P +I P G+ T P Y SR +P
Sbjct: 444 EHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVP 503
Query: 512 KGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLL 571
H + P E F Y+WTV E GPT +DP CL + Y S V+ +D+ +GLIGP+
Sbjct: 504 PSASH-----VAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGLIGPMK 558
Query: 572 ICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASN 631
IC K S+ G Q DK + +VFDEN S L +NI+ F P V ED +FQ SN
Sbjct: 559 ICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESN 618
Query: 632 IMHSINGYVFDSLQ-LSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLF 690
MHS+NG+++ + L++C + WY+ S G + D ++FSG T+ + DT LF
Sbjct: 619 KMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLF 678
Query: 691 PFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCDKNTGD 736
P + T+ M + G + + C +D GM V+ C + + D
Sbjct: 679 PQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSED 724
Score = 369 bits (948), Expect = e-101
Identities = 241/736 (32%), Positives = 367/736 (49%), Gaps = 93/736 (12%)
Query: 22 RRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVV-----YKKTLFVEFTDH 76
R YY+ A E+ W+Y S + + P + F YKK ++ E+TD
Sbjct: 372 RHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDA 431
Query: 77 LFNIAKPRPP---WMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGA-- 131
F K R P +G+LGP I AEV DT+ +T N ++P+S+ +GV + K +EG
Sbjct: 432 SFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYY 491
Query: 132 --EYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNS 189
Y+ Q+ V P + TY W V KE GP +DP+CL Y S VD KD+ +
Sbjct: 492 SPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFT 551
Query: 190 GLIGALLVCREGSL-AKEKTQTLHKFILLF-AVFDEGKSWHSETKNSLMQ------DRDA 241
GLIG + +C++GSL A + + + K LF VFDE +S E + D++
Sbjct: 552 GLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKED 611
Query: 242 ASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHR 301
+ KMH++NG++ + PGL C SV W++ G +VH I+ G+T+L R R
Sbjct: 612 EDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGER 671
Query: 302 QASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEE 361
+ + + P T LT G F + C + H GM+ V+ C + +E+
Sbjct: 672 RDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQC-------RRQSED 724
Query: 362 AEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPL---- 417
+ Y + T +YIAA E +WDY+P
Sbjct: 725 STFYLGERT--------------------------------YYIAAVEVEWDYSPQREWE 752
Query: 418 --VLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKT---REAIQHESGILGPLL 472
+ +++ + +L+ G IG KYKKV + YTD TF+ R+A + GILGP L
Sbjct: 753 KELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQL 812
Query: 473 YGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKW 532
+ +VGD + IIFKN A+RPY+I+ HG+ + P LPGE Y W
Sbjct: 813 HADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVT-------------PTLPGETLTYVW 859
Query: 533 TVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNV 592
+ G D C+ Y S V+ +DL SGLIGPL++C + + ++ + +R +
Sbjct: 860 KIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYL-----KVFNPRRKL 914
Query: 593 ---ILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQ-LSV 648
+LF VFDEN SWYL +NI+ + +P V +D EF SN MH+ING +F +LQ L++
Sbjct: 915 EFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTM 974
Query: 649 CLHEVAYWYILSIGAQTDFLSVFFSGYTF--KHKMVY-EDTLTLFPFSGETVFMSMENPG 705
+ + WY++ +G + D +V F G++F KH+ VY D +FP + +T+ M PG
Sbjct: 975 HVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPG 1034
Query: 706 LWILGCHNSDFRNRGM 721
+W+L CH +D + GM
Sbjct: 1035 IWLLHCHVTDHIHAGM 1050
Score = 243 bits (619), Expect = 2e-63
Identities = 125/360 (34%), Positives = 193/360 (53%), Gaps = 22/360 (6%)
Query: 1693 KEDFDIYDEDENQSPRSFQKKTRHYFIAAVERLWDYG----MSSSPHVLRNRAQSGSV-- 1746
K+ + + +F R Y+IAAVE WDY H L+ + S +
Sbjct: 710 KQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLD 769
Query: 1747 -------PQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQAS 1799
++KKVV++++TD +F P+ R EHLG+LGP + A+V D + + F+N A+
Sbjct: 770 KGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMAT 829
Query: 1800 RPYSFYSSLISYEEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSD 1859
RPYS ++ + E P P ET TY WK+ ++ C WAY+S
Sbjct: 830 RPYSIHAHGVQTESST---VTP----TLPGETLTYVWKIPERSGAGTEDSACIPWAYYST 882
Query: 1860 VDLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCR 1919
VD KD++SGLIGPL+VC L + R+ EFAL F +FDE +SWY +N++
Sbjct: 883 VDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKL--EFALLFLVFDENESWYLDDNIKTYSD 940
Query: 1920 APCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSG 1979
P + +D F E+ + HAING + L GL M + WYL+ MG+ ++H++HF G
Sbjct: 941 HPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHG 1000
Query: 1980 HVFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNK 2039
H F + + Y +++++PG ++T+EM P GIW + C + +H+HAGM T + V N+
Sbjct: 1001 HSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNE 1060
Score = 211 bits (537), Expect = 7e-54
Identities = 126/357 (35%), Positives = 185/357 (51%), Gaps = 33/357 (9%)
Query: 1712 KKTRHYFIAAVERLWDYGMS--------------SSPHVLRNRAQSGSVPQFKKVVFQEF 1757
K RHY+IAA E +W+Y S S V + + +KK+V++E+
Sbjct: 369 KHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREY 428
Query: 1758 TDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEED--- 1814
TD SFT RG EHLG+LGP I AEV D I VTF N+ + P S + + ++
Sbjct: 429 TDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEG 488
Query: 1815 ---------QRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKD 1865
Q + P + V P ET TY W V + PT + C A Y+S VD KD
Sbjct: 489 TYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKD 548
Query: 1866 VHSGLIGPLLVCHTNTLNPAHGRQVTV-QEFALFFTIFDETKSWYFTENMERNCRAPCNI 1924
+ +GLIGP+ +C +L+ A+GRQ V +EF LF T+FDE +S +N+ AP +
Sbjct: 549 IFTGLIGPMKICKKGSLH-ANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQV 607
Query: 1925 QMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTV 1984
ED F+E+ + H++NG++ PGL M + + WYL S G+ ++H I+FSG+ +
Sbjct: 608 DKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLW 667
Query: 1985 RKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQ 2041
R + + NL+P T+ M P G + VECL +H GM + V N+C+
Sbjct: 668 RGE---RRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTV--NQCR 719
Score = 197 bits (501), Expect = 1e-49
Identities = 112/377 (29%), Positives = 183/377 (48%), Gaps = 31/377 (8%)
Query: 1713 KTRHYFIAAVERLWDYGMS-------------SSPHVLRNRAQSGSVPQFKKVVFQEFTD 1759
K +HY+I +E WDY S+ ++ + G + +KK ++ ++TD
Sbjct: 20 KEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRL--YKKALYLQYTD 77
Query: 1760 GSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQRQGA 1819
+F + E LG LGP I+AE D + V +N ASRPY+F+S I+Y ++
Sbjct: 78 ETFRTTI---EKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAI 134
Query: 1820 EPRKNF--------VKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLI 1871
P V P E TY +P + + +C Y S +D KD+ SGLI
Sbjct: 135 YPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLI 194
Query: 1872 GPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTF 1931
GPL++C ++L+ + + +EF + F++ DE SWY +N++ C P + ++ F
Sbjct: 195 GPLIICKKDSLDKEKEKHID-REFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDF 253
Query: 1932 KENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYK 1991
+E+ R +++NGY +LPGL M + R++WYL MG+ ++H+ F G T + Y+
Sbjct: 254 QESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALT---NKNYR 310
Query: 1992 MALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYS-NKCQTPLGMASGH 2050
+ NL+P M+ G W + C HL AG+ F V NK + + H
Sbjct: 311 IDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKH 370
Query: 2051 IRDFQITASGQYGQWAP 2067
+R + I A +AP
Sbjct: 371 VRHYYIAAEEIIWNYAP 387
Score = 171 bits (432), Expect = 1e-41
Identities = 110/335 (32%), Positives = 161/335 (48%), Gaps = 31/335 (9%)
Query: 22 RRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSF----PFNTSVVYKKTLFVEFTDHL 77
R YY+ AVE+ WDY E + V +F F YKK ++ ++TD
Sbjct: 732 RTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDST 791
Query: 78 FNIA---KPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYD 134
F + K +G+LGP + A+V D V I KNMA+ P S+HA GV ++
Sbjct: 792 FRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTV----- 846
Query: 135 DQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGA 194
PG + TYVW++ + +G D C+ ++Y S VD VKDL SGLIG
Sbjct: 847 ----------TPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGP 896
Query: 195 LLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQD------RDAASARAWP 248
L+VCR L + +F LLF VFDE +SW+ + D +D
Sbjct: 897 LIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESN 956
Query: 249 KMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQAS---L 305
KMH +NG + +L GL V W+++GMG ++H++ GH+F ++ S
Sbjct: 957 KMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVF 1016
Query: 306 EISPITFLTAQTLLMDLGQFLLFCHISSHQHDGME 340
+I P T+ T + G +LL CH++ H H GME
Sbjct: 1017 DIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGME 1051
>gi|195963313 hephaestin isoform a [Homo sapiens]
Length = 1161
Score = 417 bits (1071), Expect = e-116
Identities = 251/735 (34%), Positives = 370/735 (50%), Gaps = 64/735 (8%)
Query: 20 ATRRYYLGAVELSWDYM---QSDLGELPVDARF-PPRVPKSFPFNTSVVYKKTLFVEFTD 75
ATR YYLG ++ W+Y ++ + P+D+ KS YKKT++ E+ D
Sbjct: 27 ATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKD 86
Query: 76 HLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDD 135
+ +P W+G LGP +QAEV D ++I LKN A+ P ++H GV Y K SEG+ Y D
Sbjct: 87 DSYTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPD 146
Query: 136 QTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGAL 195
+S K DD V PGGSH Y W + + + P +DP CLT+ Y SHVD +D+ +GLIG L
Sbjct: 147 GSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPL 206
Query: 196 LVCREGSL----AKEKTQTLHKFILLFAVFDEGKSWH------SETKNSLMQDRDAASAR 245
+ C+ G+L ++ H F LLF+V DE SWH + + D++ + +
Sbjct: 207 ITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQ 266
Query: 246 AWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASL 305
+MH +NG+V +LP L C +K V WH+ GMG +VH+ F G R H
Sbjct: 267 ESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVA 326
Query: 306 EISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEAEDY 365
I P TF+TA+ + + G +L+ C ++SH DGM+A KV SC P +
Sbjct: 327 NIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPV----------- 375
Query: 366 DDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPL-------V 418
D LT K ++I A E WDY P+
Sbjct: 376 -DLLTG---------------------------KVRQYFIEAHEIQWDYGPMGHDGSTGK 407
Query: 419 LAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHES--GILGPLLYGEV 476
+ S ++ RIG Y KVR+ A+ DETF+ + ++ + GILGP++ EV
Sbjct: 408 NLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEV 467
Query: 477 GDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTV 536
GDT+ ++F N+AS+P+++ PHG+ + Y + P E Y+WTV
Sbjct: 468 GDTIQVVFYNRASQPFSMQPHGVFYEKD-YEGTVYNDGSSYPGLVAKPFEKVTYRWTVPP 526
Query: 537 EDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFS 596
GPT DP CLT Y S + RD SGL+GPLL+C ++ G Q DK +LF+
Sbjct: 527 HAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFT 586
Query: 597 VFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSL-QLSVCLHEVAY 655
V DEN+SWY N + + + + FQ SN MH+ING++F +L +L +C +
Sbjct: 587 VLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVA 646
Query: 656 WYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSD 715
W++L +G +TD V F G T + + + + LFP + M +N G + + C
Sbjct: 647 WHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGS 706
Query: 716 FRNRGMTALLKVSSC 730
R GM A+ VS C
Sbjct: 707 HREAGMRAIYNVSQC 721
Score = 387 bits (994), Expect = e-107
Identities = 250/751 (33%), Positives = 366/751 (48%), Gaps = 109/751 (14%)
Query: 22 RRYYLGAVELSWDY--MQSDLGELPVDARFPPRVPKSFPFNTSV----VYKKTLFVEFTD 75
R+Y++ A E+ WDY M D G + R P + F +S Y K + F D
Sbjct: 383 RQYFIEAHEIQWDYGPMGHD-GSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQD 441
Query: 76 HLFN--IAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEY 133
F + +G+LGP I+AEV DT+ + N AS P S+ GV Y K EG Y
Sbjct: 442 ETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVY 501
Query: 134 DDQTSQR---EKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSG 190
+D +S K +KV TY W V GP A DP CLT+ Y S D ++D NSG
Sbjct: 502 NDGSSYPGLVAKPFEKV------TYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSG 555
Query: 191 LIGALLVCREGSLAKEKTQ--TLHKFILLFAVFDEGKSWHSETKNSL------MQDRDAA 242
L+G LLVCR G+L + Q +F LLF V DE KSW+S + + D
Sbjct: 556 LVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIE 615
Query: 243 SARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQ 302
+ +MH +NG++ +LP L C +V WH++G+GT +VH + +G+T ++ R+
Sbjct: 616 GFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRK 675
Query: 303 ASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEA 362
+ + P TF+ A +LG F ++C SH+ GM A V CP + + A
Sbjct: 676 GAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAA 735
Query: 363 EDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLAPD 422
++YI AEE +WDY P
Sbjct: 736 R--------------------------------------IYYIMAEEVEWDYCP------ 751
Query: 423 DRSYKSQ-------------YLNNGPQRIGRKYKKVRFMAYTDETF---KTREAIQHESG 466
DRS++ + +L+N +G +YKK F YTD TF + R + G
Sbjct: 752 DRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHLG 811
Query: 467 ILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGI---TDVRPLYSRRLPKGVKHLKDFPIL 523
ILGPL+ GEVGD L ++FKN ASRPY+++ HG+ T V PL +
Sbjct: 812 ILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAE--------------- 856
Query: 524 PGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGN 583
PGE+ Y+W + GP +D C++ Y S V+ +D+ SGL+GPL IC K ++ G
Sbjct: 857 PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGG 916
Query: 584 QIMSDKRNVILFSVFDENRSWYLTENIQRF-LPNPAGVQLEDPEFQASNIMHSINGYVFD 642
+ D+ +LF +FDEN+SWYL EN+ +P + L+D F SN MH+ING ++
Sbjct: 917 RSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYA 976
Query: 643 SLQ-LSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHK---MVYEDTLTLFPFSGETVF 698
+L+ L++ E WY+L++G D ++ F +F ++ D + LFP + E V
Sbjct: 977 NLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVE 1036
Query: 699 MSMENPGLWILGCHNSDFRNRGMTALLKVSS 729
M NPG W++ CH +D + GM L V S
Sbjct: 1037 MVASNPGTWLMHCHVTDHVHAGMETLFTVFS 1067
Score = 254 bits (650), Expect = 5e-67
Identities = 137/347 (39%), Positives = 193/347 (55%), Gaps = 21/347 (6%)
Query: 1706 SPRSFQKKTRHYFIAAVERLWDYGMSSS-PHVLRNRAQSGSV-------------PQFKK 1751
+PR + R Y+I A E WDY S N+++ S ++KK
Sbjct: 727 TPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKK 786
Query: 1752 VVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISY 1811
VF+E+TDG+F P R EHLG+LGP I+ EV D + V F+N ASRPYS ++ +
Sbjct: 787 AVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLE 846
Query: 1812 EEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLI 1871
A +P E TY W + P ++ C +W Y+S VD KD++SGL+
Sbjct: 847 STTVWPLA------AEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV 900
Query: 1872 GPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERN-CRAPCNIQMEDPT 1930
GPL +C L P GR +EFAL F IFDE KSWY EN+ + + P +I ++D T
Sbjct: 901 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET 960
Query: 1931 FKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEY 1990
F E+ + HAING + L GL M Q +R+ WY+L+MG + ++H+IHF F R E Y
Sbjct: 961 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY 1020
Query: 1991 KMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYS 2037
+ + +L+PG FE VEM+ S G W + C + +H+HAGM TLF V+S
Sbjct: 1021 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFS 1067
Score = 206 bits (525), Expect = 2e-52
Identities = 115/375 (30%), Positives = 180/375 (48%), Gaps = 29/375 (7%)
Query: 1707 PRSFQKKTRHYFIAAVERLWDYGMSSSPHVLRNRAQSGSVPQ-------------FKKVV 1753
P+ TR Y++ + W+Y + S V +KK +
Sbjct: 21 PQLTDGATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTI 80
Query: 1754 FQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEE 1813
++E+ D S+T + + LG LGP ++AEV D I++ +N A+RPY+ + + YE+
Sbjct: 81 YKEYKDDSYTDEVAQPAW---LGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEK 137
Query: 1814 DQRQGAEP--------RKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKD 1865
D P + V P + Y W + APT + C W Y S VD +D
Sbjct: 138 DSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRD 197
Query: 1866 VHSGLIGPLLVCHTNTL--NPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCN 1923
+ +GLIGPL+ C L N RQ +F L F++ DE SW+ EN+ C P +
Sbjct: 198 IATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPAS 257
Query: 1924 IQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFT 1983
+ ED TF+E+ R HAING++ LP L M +R+ W+L MG+ ++H+ F G + T
Sbjct: 258 VDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLT 317
Query: 1984 VRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTP 2043
R + + N++P F T EM+P + G W + C + H GM L+ V S P
Sbjct: 318 TR---GHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPP 374
Query: 2044 LGMASGHIRDFQITA 2058
+ + +G +R + I A
Sbjct: 375 VDLLTGKVRQYFIEA 389
Score = 195 bits (496), Expect = 4e-49
Identities = 123/343 (35%), Positives = 171/343 (49%), Gaps = 25/343 (7%)
Query: 1713 KTRHYFIAAVERLWDYG-MSSSPHVLRNRAQSGSVPQ-------------FKKVVFQEFT 1758
K R YFI A E WDYG M +N + GS+ + KV ++ F
Sbjct: 381 KVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQ 440
Query: 1759 DGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQR-- 1816
D +F + ++ E + HLG+LGP IRAEV D I V F N+AS+P+S + YE+D
Sbjct: 441 DETFQEKMHLEE-DRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGT 499
Query: 1817 ---QGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGP 1873
G+ KP E TY W V H PT + C W YFS D +D +SGL+GP
Sbjct: 500 VYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGP 559
Query: 1874 LLVCHTNTLNPAHGRQVTV-QEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFK 1932
LLVC L A G+Q V +EF L FT+ DE KSWY N + + F+
Sbjct: 560 LLVCRAGALG-ADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQ 618
Query: 1933 ENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKM 1992
++ R HAING++ LP L M + + W+LL +G+ ++H + F G+ TV+ + K
Sbjct: 619 DSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGN--TVQLQGMRKG 676
Query: 1993 ALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLV 2035
A L+P F M P G + + C G H AGM ++ V
Sbjct: 677 AAM-LFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNV 718
Score = 166 bits (421), Expect = 2e-40
Identities = 114/357 (31%), Positives = 172/357 (48%), Gaps = 42/357 (11%)
Query: 18 FSATRRYYLGAVELSWDYMQSDLGELPVDARFPP-RVPKSFPFNTSVV----YKKTLFVE 72
+ A R YY+ A E+ WDY E + F N + YKK +F E
Sbjct: 732 YQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFRE 791
Query: 73 FTDHLFNIAKPRP---PWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGV----SYW 125
+TD F I +PR +G+LGP I+ EV D + + KN AS P S+HA GV + W
Sbjct: 792 YTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVW 851
Query: 126 KASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVK 185
+ AE PG TY W + + +GP +D C+++ Y S VD +K
Sbjct: 852 PLA--AE----------------PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIK 893
Query: 186 DLNSGLIGALLVCREGSLAKE--KTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRDAAS 243
D+ SGL+G L +C++G L ++ +F LLF +FDE KSW+ E + +D S
Sbjct: 894 DMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGS 953
Query: 244 ARAWP-------KMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFL 296
KMH +NG + +L GL + V W+++ MG ++H+I +FL
Sbjct: 954 INLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFL 1013
Query: 297 VRN---HRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPE 350
RN +R +++ P TF + + + G +L+ CH++ H H GME V S E
Sbjct: 1014 YRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTE 1070
>gi|195947365 hephaestin isoform c [Homo sapiens]
Length = 1160
Score = 417 bits (1071), Expect = e-116
Identities = 251/735 (34%), Positives = 370/735 (50%), Gaps = 64/735 (8%)
Query: 20 ATRRYYLGAVELSWDYM---QSDLGELPVDARF-PPRVPKSFPFNTSVVYKKTLFVEFTD 75
ATR YYLG ++ W+Y ++ + P+D+ KS YKKT++ E+ D
Sbjct: 27 ATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKD 86
Query: 76 HLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDD 135
+ +P W+G LGP +QAEV D ++I LKN A+ P ++H GV Y K SEG+ Y D
Sbjct: 87 DSYTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPD 146
Query: 136 QTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGAL 195
+S K DD V PGGSH Y W + + + P +DP CLT+ Y SHVD +D+ +GLIG L
Sbjct: 147 GSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPL 206
Query: 196 LVCREGSL----AKEKTQTLHKFILLFAVFDEGKSWH------SETKNSLMQDRDAASAR 245
+ C+ G+L ++ H F LLF+V DE SWH + + D++ + +
Sbjct: 207 ITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQ 266
Query: 246 AWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASL 305
+MH +NG+V +LP L C +K V WH+ GMG +VH+ F G R H
Sbjct: 267 ESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVA 326
Query: 306 EISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEAEDY 365
I P TF+TA+ + + G +L+ C ++SH DGM+A KV SC P +
Sbjct: 327 NIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPV----------- 375
Query: 366 DDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPL-------V 418
D LT K ++I A E WDY P+
Sbjct: 376 -DLLTG---------------------------KVRQYFIEAHEIQWDYGPMGHDGSTGK 407
Query: 419 LAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHES--GILGPLLYGEV 476
+ S ++ RIG Y KVR+ A+ DETF+ + ++ + GILGP++ EV
Sbjct: 408 NLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEV 467
Query: 477 GDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTV 536
GDT+ ++F N+AS+P+++ PHG+ + Y + P E Y+WTV
Sbjct: 468 GDTIQVVFYNRASQPFSMQPHGVFYEKD-YEGTVYNDGSSYPGLVAKPFEKVTYRWTVPP 526
Query: 537 EDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFS 596
GPT DP CLT Y S + RD SGL+GPLL+C ++ G Q DK +LF+
Sbjct: 527 HAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFT 586
Query: 597 VFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSL-QLSVCLHEVAY 655
V DEN+SWY N + + + + FQ SN MH+ING++F +L +L +C +
Sbjct: 587 VLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVA 646
Query: 656 WYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSD 715
W++L +G +TD V F G T + + + + LFP + M +N G + + C
Sbjct: 647 WHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGS 706
Query: 716 FRNRGMTALLKVSSC 730
R GM A+ VS C
Sbjct: 707 HREAGMRAIYNVSQC 721
Score = 387 bits (994), Expect = e-107
Identities = 250/751 (33%), Positives = 366/751 (48%), Gaps = 109/751 (14%)
Query: 22 RRYYLGAVELSWDY--MQSDLGELPVDARFPPRVPKSFPFNTSV----VYKKTLFVEFTD 75
R+Y++ A E+ WDY M D G + R P + F +S Y K + F D
Sbjct: 383 RQYFIEAHEIQWDYGPMGHD-GSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQD 441
Query: 76 HLFN--IAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEY 133
F + +G+LGP I+AEV DT+ + N AS P S+ GV Y K EG Y
Sbjct: 442 ETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVY 501
Query: 134 DDQTSQR---EKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSG 190
+D +S K +KV TY W V GP A DP CLT+ Y S D ++D NSG
Sbjct: 502 NDGSSYPGLVAKPFEKV------TYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSG 555
Query: 191 LIGALLVCREGSLAKEKTQ--TLHKFILLFAVFDEGKSWHSETKNSL------MQDRDAA 242
L+G LLVCR G+L + Q +F LLF V DE KSW+S + + D
Sbjct: 556 LVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIE 615
Query: 243 SARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQ 302
+ +MH +NG++ +LP L C +V WH++G+GT +VH + +G+T ++ R+
Sbjct: 616 GFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRK 675
Query: 303 ASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEA 362
+ + P TF+ A +LG F ++C SH+ GM A V CP + + A
Sbjct: 676 GAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAA 735
Query: 363 EDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLAPD 422
++YI AEE +WDY P
Sbjct: 736 R--------------------------------------IYYIMAEEVEWDYCP------ 751
Query: 423 DRSYKSQ-------------YLNNGPQRIGRKYKKVRFMAYTDETF---KTREAIQHESG 466
DRS++ + +L+N +G +YKK F YTD TF + R + G
Sbjct: 752 DRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHLG 811
Query: 467 ILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGI---TDVRPLYSRRLPKGVKHLKDFPIL 523
ILGPL+ GEVGD L ++FKN ASRPY+++ HG+ T V PL +
Sbjct: 812 ILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAE--------------- 856
Query: 524 PGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGN 583
PGE+ Y+W + GP +D C++ Y S V+ +D+ SGL+GPL IC K ++ G
Sbjct: 857 PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGG 916
Query: 584 QIMSDKRNVILFSVFDENRSWYLTENIQRF-LPNPAGVQLEDPEFQASNIMHSINGYVFD 642
+ D+ +LF +FDEN+SWYL EN+ +P + L+D F SN MH+ING ++
Sbjct: 917 RSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYA 976
Query: 643 SLQ-LSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHK---MVYEDTLTLFPFSGETVF 698
+L+ L++ E WY+L++G D ++ F +F ++ D + LFP + E V
Sbjct: 977 NLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVE 1036
Query: 699 MSMENPGLWILGCHNSDFRNRGMTALLKVSS 729
M NPG W++ CH +D + GM L V S
Sbjct: 1037 MVASNPGTWLMHCHVTDHVHAGMETLFTVFS 1067
Score = 254 bits (650), Expect = 5e-67
Identities = 137/347 (39%), Positives = 193/347 (55%), Gaps = 21/347 (6%)
Query: 1706 SPRSFQKKTRHYFIAAVERLWDYGMSSS-PHVLRNRAQSGSV-------------PQFKK 1751
+PR + R Y+I A E WDY S N+++ S ++KK
Sbjct: 727 TPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKK 786
Query: 1752 VVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISY 1811
VF+E+TDG+F P R EHLG+LGP I+ EV D + V F+N ASRPYS ++ +
Sbjct: 787 AVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLE 846
Query: 1812 EEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLI 1871
A +P E TY W + P ++ C +W Y+S VD KD++SGL+
Sbjct: 847 STTVWPLA------AEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV 900
Query: 1872 GPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERN-CRAPCNIQMEDPT 1930
GPL +C L P GR +EFAL F IFDE KSWY EN+ + + P +I ++D T
Sbjct: 901 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET 960
Query: 1931 FKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEY 1990
F E+ + HAING + L GL M Q +R+ WY+L+MG + ++H+IHF F R E Y
Sbjct: 961 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY 1020
Query: 1991 KMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYS 2037
+ + +L+PG FE VEM+ S G W + C + +H+HAGM TLF V+S
Sbjct: 1021 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFS 1067
Score = 206 bits (525), Expect = 2e-52
Identities = 115/375 (30%), Positives = 180/375 (48%), Gaps = 29/375 (7%)
Query: 1707 PRSFQKKTRHYFIAAVERLWDYGMSSSPHVLRNRAQSGSVPQ-------------FKKVV 1753
P+ TR Y++ + W+Y + S V +KK +
Sbjct: 21 PQLTDGATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTI 80
Query: 1754 FQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEE 1813
++E+ D S+T + + LG LGP ++AEV D I++ +N A+RPY+ + + YE+
Sbjct: 81 YKEYKDDSYTDEVAQPAW---LGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEK 137
Query: 1814 DQRQGAEP--------RKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKD 1865
D P + V P + Y W + APT + C W Y S VD +D
Sbjct: 138 DSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRD 197
Query: 1866 VHSGLIGPLLVCHTNTL--NPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCN 1923
+ +GLIGPL+ C L N RQ +F L F++ DE SW+ EN+ C P +
Sbjct: 198 IATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPAS 257
Query: 1924 IQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFT 1983
+ ED TF+E+ R HAING++ LP L M +R+ W+L MG+ ++H+ F G + T
Sbjct: 258 VDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLT 317
Query: 1984 VRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTP 2043
R + + N++P F T EM+P + G W + C + H GM L+ V S P
Sbjct: 318 TR---GHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPP 374
Query: 2044 LGMASGHIRDFQITA 2058
+ + +G +R + I A
Sbjct: 375 VDLLTGKVRQYFIEA 389
Score = 195 bits (496), Expect = 4e-49
Identities = 123/343 (35%), Positives = 171/343 (49%), Gaps = 25/343 (7%)
Query: 1713 KTRHYFIAAVERLWDYG-MSSSPHVLRNRAQSGSVPQ-------------FKKVVFQEFT 1758
K R YFI A E WDYG M +N + GS+ + KV ++ F
Sbjct: 381 KVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQ 440
Query: 1759 DGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQR-- 1816
D +F + ++ E + HLG+LGP IRAEV D I V F N+AS+P+S + YE+D
Sbjct: 441 DETFQEKMHLEE-DRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGT 499
Query: 1817 ---QGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGP 1873
G+ KP E TY W V H PT + C W YFS D +D +SGL+GP
Sbjct: 500 VYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGP 559
Query: 1874 LLVCHTNTLNPAHGRQVTV-QEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFK 1932
LLVC L A G+Q V +EF L FT+ DE KSWY N + + F+
Sbjct: 560 LLVCRAGALG-ADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQ 618
Query: 1933 ENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKM 1992
++ R HAING++ LP L M + + W+LL +G+ ++H + F G+ TV+ + K
Sbjct: 619 DSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGN--TVQLQGMRKG 676
Query: 1993 ALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLV 2035
A L+P F M P G + + C G H AGM ++ V
Sbjct: 677 AAM-LFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNV 718
Score = 166 bits (421), Expect = 2e-40
Identities = 114/357 (31%), Positives = 172/357 (48%), Gaps = 42/357 (11%)
Query: 18 FSATRRYYLGAVELSWDYMQSDLGELPVDARFPP-RVPKSFPFNTSVV----YKKTLFVE 72
+ A R YY+ A E+ WDY E + F N + YKK +F E
Sbjct: 732 YQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFRE 791
Query: 73 FTDHLFNIAKPRP---PWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGV----SYW 125
+TD F I +PR +G+LGP I+ EV D + + KN AS P S+HA GV + W
Sbjct: 792 YTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVW 851
Query: 126 KASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVK 185
+ AE PG TY W + + +GP +D C+++ Y S VD +K
Sbjct: 852 PLA--AE----------------PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIK 893
Query: 186 DLNSGLIGALLVCREGSLAKE--KTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRDAAS 243
D+ SGL+G L +C++G L ++ +F LLF +FDE KSW+ E + +D S
Sbjct: 894 DMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGS 953
Query: 244 ARAWP-------KMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFL 296
KMH +NG + +L GL + V W+++ MG ++H+I +FL
Sbjct: 954 INLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFL 1013
Query: 297 VRN---HRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPE 350
RN +R +++ P TF + + + G +L+ CH++ H H GME V S E
Sbjct: 1014 YRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTE 1070
>gi|7662254 hephaestin isoform b [Homo sapiens]
Length = 891
Score = 387 bits (994), Expect = e-107
Identities = 250/751 (33%), Positives = 366/751 (48%), Gaps = 109/751 (14%)
Query: 22 RRYYLGAVELSWDY--MQSDLGELPVDARFPPRVPKSFPFNTSV----VYKKTLFVEFTD 75
R+Y++ A E+ WDY M D G + R P + F +S Y K + F D
Sbjct: 113 RQYFIEAHEIQWDYGPMGHD-GSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQD 171
Query: 76 HLFN--IAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEY 133
F + +G+LGP I+AEV DT+ + N AS P S+ GV Y K EG Y
Sbjct: 172 ETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVY 231
Query: 134 DDQTSQR---EKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSG 190
+D +S K +KV TY W V GP A DP CLT+ Y S D ++D NSG
Sbjct: 232 NDGSSYPGLVAKPFEKV------TYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSG 285
Query: 191 LIGALLVCREGSLAKEKTQ--TLHKFILLFAVFDEGKSWHSETKNSL------MQDRDAA 242
L+G LLVCR G+L + Q +F LLF V DE KSW+S + + D
Sbjct: 286 LVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIE 345
Query: 243 SARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQ 302
+ +MH +NG++ +LP L C +V WH++G+GT +VH + +G+T ++ R+
Sbjct: 346 GFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRK 405
Query: 303 ASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEA 362
+ + P TF+ A +LG F ++C SH+ GM A V CP + + A
Sbjct: 406 GAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAA 465
Query: 363 EDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLAPD 422
++YI AEE +WDY P
Sbjct: 466 R--------------------------------------IYYIMAEEVEWDYCP------ 481
Query: 423 DRSYKSQ-------------YLNNGPQRIGRKYKKVRFMAYTDETF---KTREAIQHESG 466
DRS++ + +L+N +G +YKK F YTD TF + R + G
Sbjct: 482 DRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHLG 541
Query: 467 ILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGI---TDVRPLYSRRLPKGVKHLKDFPIL 523
ILGPL+ GEVGD L ++FKN ASRPY+++ HG+ T V PL +
Sbjct: 542 ILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAE--------------- 586
Query: 524 PGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGN 583
PGE+ Y+W + GP +D C++ Y S V+ +D+ SGL+GPL IC K ++ G
Sbjct: 587 PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGG 646
Query: 584 QIMSDKRNVILFSVFDENRSWYLTENIQRF-LPNPAGVQLEDPEFQASNIMHSINGYVFD 642
+ D+ +LF +FDEN+SWYL EN+ +P + L+D F SN MH+ING ++
Sbjct: 647 RSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYA 706
Query: 643 SLQ-LSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHK---MVYEDTLTLFPFSGETVF 698
+L+ L++ E WY+L++G D ++ F +F ++ D + LFP + E V
Sbjct: 707 NLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVE 766
Query: 699 MSMENPGLWILGCHNSDFRNRGMTALLKVSS 729
M NPG W++ CH +D + GM L V S
Sbjct: 767 MVASNPGTWLMHCHVTDHVHAGMETLFTVFS 797
Score = 263 bits (673), Expect = 1e-69
Identities = 161/491 (32%), Positives = 237/491 (48%), Gaps = 50/491 (10%)
Query: 250 MHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISP 309
MH +NG+V +LP L C +K V WH+ GMG +VH+ F G R H I P
Sbjct: 1 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 60
Query: 310 ITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEAEDYDDDL 369
TF+TA+ + + G +L+ C ++SH DGM+A KV SC P + D L
Sbjct: 61 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPV------------DLL 108
Query: 370 TDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPL-------VLAPD 422
T K ++I A E WDY P+ +
Sbjct: 109 TG---------------------------KVRQYFIEAHEIQWDYGPMGHDGSTGKNLRE 141
Query: 423 DRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHES--GILGPLLYGEVGDTL 480
S ++ RIG Y KVR+ A+ DETF+ + ++ + GILGP++ EVGDT+
Sbjct: 142 PGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTI 201
Query: 481 LIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGP 540
++F N+AS+P+++ PHG+ + Y + P E Y+WTV GP
Sbjct: 202 QVVFYNRASQPFSMQPHGVFYEKD-YEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGP 260
Query: 541 TKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDE 600
T DP CLT Y S + RD SGL+GPLL+C ++ G Q DK +LF+V DE
Sbjct: 261 TAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDE 320
Query: 601 NRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSL-QLSVCLHEVAYWYIL 659
N+SWY N + + + + FQ SN MH+ING++F +L +L +C + W++L
Sbjct: 321 NKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLL 380
Query: 660 SIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNR 719
+G +TD V F G T + + + + LFP + M +N G + + C R
Sbjct: 381 GLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREA 440
Query: 720 GMTALLKVSSC 730
GM A+ VS C
Sbjct: 441 GMRAIYNVSQC 451
Score = 254 bits (650), Expect = 5e-67
Identities = 137/347 (39%), Positives = 193/347 (55%), Gaps = 21/347 (6%)
Query: 1706 SPRSFQKKTRHYFIAAVERLWDYGMSSS-PHVLRNRAQSGSV-------------PQFKK 1751
+PR + R Y+I A E WDY S N+++ S ++KK
Sbjct: 457 TPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKK 516
Query: 1752 VVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISY 1811
VF+E+TDG+F P R EHLG+LGP I+ EV D + V F+N ASRPYS ++ +
Sbjct: 517 AVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLE 576
Query: 1812 EEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLI 1871
A +P E TY W + P ++ C +W Y+S VD KD++SGL+
Sbjct: 577 STTVWPLA------AEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV 630
Query: 1872 GPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERN-CRAPCNIQMEDPT 1930
GPL +C L P GR +EFAL F IFDE KSWY EN+ + + P +I ++D T
Sbjct: 631 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET 690
Query: 1931 FKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEY 1990
F E+ + HAING + L GL M Q +R+ WY+L+MG + ++H+IHF F R E Y
Sbjct: 691 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY 750
Query: 1991 KMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYS 2037
+ + +L+PG FE VEM+ S G W + C + +H+HAGM TLF V+S
Sbjct: 751 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFS 797
Score = 195 bits (496), Expect = 4e-49
Identities = 123/343 (35%), Positives = 171/343 (49%), Gaps = 25/343 (7%)
Query: 1713 KTRHYFIAAVERLWDYG-MSSSPHVLRNRAQSGSVPQ-------------FKKVVFQEFT 1758
K R YFI A E WDYG M +N + GS+ + KV ++ F
Sbjct: 111 KVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQ 170
Query: 1759 DGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQR-- 1816
D +F + ++ E + HLG+LGP IRAEV D I V F N+AS+P+S + YE+D
Sbjct: 171 DETFQEKMHLEE-DRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGT 229
Query: 1817 ---QGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGP 1873
G+ KP E TY W V H PT + C W YFS D +D +SGL+GP
Sbjct: 230 VYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGP 289
Query: 1874 LLVCHTNTLNPAHGRQVTV-QEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFK 1932
LLVC L A G+Q V +EF L FT+ DE KSWY N + + F+
Sbjct: 290 LLVCRAGALG-ADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQ 348
Query: 1933 ENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKM 1992
++ R HAING++ LP L M + + W+LL +G+ ++H + F G+ TV+ + K
Sbjct: 349 DSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGN--TVQLQGMRKG 406
Query: 1993 ALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLV 2035
A L+P F M P G + + C G H AGM ++ V
Sbjct: 407 AAM-LFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNV 448
Score = 166 bits (421), Expect = 2e-40
Identities = 114/357 (31%), Positives = 172/357 (48%), Gaps = 42/357 (11%)
Query: 18 FSATRRYYLGAVELSWDYMQSDLGELPVDARFPP-RVPKSFPFNTSVV----YKKTLFVE 72
+ A R YY+ A E+ WDY E + F N + YKK +F E
Sbjct: 462 YQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFRE 521
Query: 73 FTDHLFNIAKPRP---PWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGV----SYW 125
+TD F I +PR +G+LGP I+ EV D + + KN AS P S+HA GV + W
Sbjct: 522 YTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVW 581
Query: 126 KASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVK 185
+ AE PG TY W + + +GP +D C+++ Y S VD +K
Sbjct: 582 PLA--AE----------------PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIK 623
Query: 186 DLNSGLIGALLVCREGSLAKE--KTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRDAAS 243
D+ SGL+G L +C++G L ++ +F LLF +FDE KSW+ E + +D S
Sbjct: 624 DMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGS 683
Query: 244 ARAWP-------KMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFL 296
KMH +NG + +L GL + V W+++ MG ++H+I +FL
Sbjct: 684 INLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFL 743
Query: 297 VRN---HRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPE 350
RN +R +++ P TF + + + G +L+ CH++ H H GME V S E
Sbjct: 744 YRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTE 800
Score = 87.4 bits (215), Expect = 1e-16
Identities = 40/121 (33%), Positives = 64/121 (52%), Gaps = 3/121 (2%)
Query: 1938 HAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNL 1997
HAING++ LP L M +R+ W+L MG+ ++H+ F G + T R + + N+
Sbjct: 2 HAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRG---HHTDVANI 58
Query: 1998 YPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTPLGMASGHIRDFQIT 2057
+P F T EM+P + G W + C + H GM L+ V S P+ + +G +R + I
Sbjct: 59 FPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIE 118
Query: 2058 A 2058
A
Sbjct: 119 A 119
>gi|31317224 EGF-like repeats and discoidin I-like domains-containing
protein 3 [Homo sapiens]
Length = 480
Score = 255 bits (651), Expect = 4e-67
Identities = 143/324 (44%), Positives = 190/324 (58%), Gaps = 13/324 (4%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQYG------QWAPKLARLHYSGSINAWSTKEP--FSWI 2090
KC PLG+ G I + QITAS + +W P ARL+ G INAW+ E + WI
Sbjct: 157 KCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWI 216
Query: 2091 KVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVD 2150
+++L M + G+ TQGA++ S YI + I YS DGK W Y+ T MVF GN+D
Sbjct: 217 QINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNID 276
Query: 2151 SSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQIT 2210
++ N F PPI A+Y+RL+P TLRMEL+GC+L+ CS PLGM+S I D QIT
Sbjct: 277 NNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQIT 336
Query: 2211 ASSYFTNM---FATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGV 2267
ASS F + TW P KARL QG+ NAW N+ +WLQVD KVTG+ TQG
Sbjct: 337 ASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGA 396
Query: 2268 KSLLTSMYVKEFLISSSQDGHQWTLF--FQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYL 2325
K +V + ++ S DG WT++ + K KVFQGN D+ T N +DPP+ R++
Sbjct: 397 KDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHI 456
Query: 2326 RIHPQSWVHQIALRMEVLGCEAQD 2349
RI P SW +I LR E+LGC ++
Sbjct: 457 RILPWSWYGRITLRSELLGCTEEE 480
>gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Homo
sapiens]
Length = 387
Score = 224 bits (571), Expect = 8e-58
Identities = 123/320 (38%), Positives = 187/320 (58%), Gaps = 14/320 (4%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQ------YGQWAPKLARLHYSGSINAW--STKEPFSWI 2090
KC PLG+ +G+I + QI AS W P+LARL+ +G +NAW S+ + WI
Sbjct: 69 KCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWI 128
Query: 2091 KVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVD 2150
+V+LL M + G+ TQGA + S Y+ F + YSL+G ++ + + F GN +
Sbjct: 129 QVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFD-FIHDVNKKHKEFVGNWN 187
Query: 2151 SSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQIT 2210
+ + N+F P+ A+Y+RL+PT TLR EL+GC+LN C+ PLG+++ +I D QIT
Sbjct: 188 KNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQIT 247
Query: 2211 ASSYFTNM---FATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGV 2267
ASS + +W+PS ARL QG NAW +WLQVD + +VTG+ TQG
Sbjct: 248 ASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGA 307
Query: 2268 KSLLTSMYVKEFLISSSQDGHQWTLFF--QNGKVKVFQGNQDSFTPVVNSLDPPLLTRYL 2325
++ + +V + ++ S D WT + + G K+F GN D+ + N + P+L RY+
Sbjct: 308 RNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILARYV 367
Query: 2326 RIHPQSWVHQIALRMEVLGC 2345
RI P +W ++IALR+E+LGC
Sbjct: 368 RILPVAWHNRIALRLELLGC 387
Score = 112 bits (281), Expect = 3e-24
Identities = 62/160 (38%), Positives = 86/160 (53%), Gaps = 9/160 (5%)
Query: 2038 NKCQTPLGMASGHIRDFQITASGQYGQWA-------PKLARLHYSGSINAW--STKEPFS 2088
N C PLG+ + I D QITAS Y W P ARL G+ NAW +
Sbjct: 228 NGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQ 287
Query: 2089 WIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGN 2148
W++VDL + + GI TQGAR S +++ + + YS D W Y+ TG+ +F GN
Sbjct: 288 WLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGN 347
Query: 2149 VDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGC 2188
D+ K N+F PI+ARY+R+ P + R LR+EL+GC
Sbjct: 348 WDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC 387
Score = 106 bits (265), Expect = 2e-22
Identities = 60/157 (38%), Positives = 85/157 (54%), Gaps = 3/157 (1%)
Query: 2193 CSMPLGMESKAISDAQITASSYFTNMFAT--WSPSKARLHLQGRSNAWRPQVNNPKEWLQ 2250
C PLG+E+ I+++QI ASS W P ARL+ G NAW P N+ W+Q
Sbjct: 70 CVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQ 129
Query: 2251 VDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQ-NGKVKVFQGNQDSF 2309
V+ + M VTGV TQG L + Y+K F ++ S +GH++ N K K F GN +
Sbjct: 130 VNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKN 189
Query: 2310 TPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE 2346
VN + P+ +Y+R++P S LR E+LGCE
Sbjct: 190 AVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCE 226
>gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Homo
sapiens]
Length = 335
Score = 175 bits (443), Expect = 5e-43
Identities = 108/318 (33%), Positives = 160/318 (50%), Gaps = 62/318 (19%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQ------YGQWAPKLARLHYSGSINAW--STKEPFSWI 2090
KC PLG+ +G+I + QI AS W P+LARL+ +G +NAW S+ + WI
Sbjct: 69 KCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWI 128
Query: 2091 KVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVD 2150
+V+LL M + G+ TQGA + S Y+ F + YSL+G ++ + + F GN +
Sbjct: 129 QVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFD-FIHDVNKKHKEFVGNWN 187
Query: 2151 SSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQIT 2210
+ + N+F P+ A+Y+RL+PT TLR EL+GC+LN C+ PLG+++ +I D QIT
Sbjct: 188 KNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQIT 247
Query: 2211 ASSYFTNM---FATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGV 2267
ASS + +W+PS ARL QG NAW +WLQ
Sbjct: 248 ASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQ----------------- 290
Query: 2268 KSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRI 2327
+F GN D+ + N + P+L RY+RI
Sbjct: 291 ---------------------------------IFPGNWDNHSHKKNLFETPILARYVRI 317
Query: 2328 HPQSWVHQIALRMEVLGC 2345
P +W ++IALR+E+LGC
Sbjct: 318 LPVAWHNRIALRLELLGC 335
Score = 106 bits (265), Expect = 2e-22
Identities = 60/157 (38%), Positives = 85/157 (54%), Gaps = 3/157 (1%)
Query: 2193 CSMPLGMESKAISDAQITASSYFTNMFAT--WSPSKARLHLQGRSNAWRPQVNNPKEWLQ 2250
C PLG+E+ I+++QI ASS W P ARL+ G NAW P N+ W+Q
Sbjct: 70 CVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQ 129
Query: 2251 VDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQ-NGKVKVFQGNQDSF 2309
V+ + M VTGV TQG L + Y+K F ++ S +GH++ N K K F GN +
Sbjct: 130 VNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKN 189
Query: 2310 TPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE 2346
VN + P+ +Y+R++P S LR E+LGCE
Sbjct: 190 AVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCE 226
Score = 64.3 bits (155), Expect = 1e-09
Identities = 46/158 (29%), Positives = 60/158 (37%), Gaps = 57/158 (36%)
Query: 2038 NKCQTPLGMASGHIRDFQITASGQYGQWA-------PKLARLHYSGSINAWSTKEPFSWI 2090
N C PLG+ + I D QITAS Y W P ARL G+ NAW
Sbjct: 228 NGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAW--------- 278
Query: 2091 KVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVD 2150
+ S +W L +F GN D
Sbjct: 279 -------------------------------VAGSYGNDQW----------LQIFPGNWD 297
Query: 2151 SSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGC 2188
+ K N+F PI+ARY+R+ P + R LR+EL+GC
Sbjct: 298 NHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC 335
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 164 bits (415), Expect = 9e-40
Identities = 117/334 (35%), Positives = 176/334 (52%), Gaps = 36/334 (10%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQY--GQWAPKLARLHYSGSINAW-----STKEPFSWIK 2091
+C PLGM SG I + QI+AS Y G+W P+ +RLH G N W S KE +++
Sbjct: 276 QCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNLDSNKE---YLQ 330
Query: 2092 VDLLAPMIIHGIKTQGA--RQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNV 2149
VDL ++ I TQGA R+ + Y+ + + S +G+ W YR VF N
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHK--VFQANN 388
Query: 2150 DSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDA 2207
D++ + N + P++ R++R+ P + LR+EL GC + CS LGM S I+D+
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2208 QITASSYFTNMFATWSPSKARLHLQGRSNAWR--PQVNNPKEWLQVDFQKTMKVTGVTTQ 2265
QI+ASS WSPS ARL + RS + PQ +EWLQVD V GV Q
Sbjct: 449 QISASS---TQEYLWSPSAARL-VSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQ 504
Query: 2266 G------VKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV---KVFQGNQDSFTPVVNSL 2316
G + ++ +V++F +S S +G W + Q+ + K+F+GN TP +
Sbjct: 505 GARGGDSITAVEARAFVRKFKVSYSLNGKDWE-YIQDPRTQQPKLFEGNMHYDTPDIRRF 563
Query: 2317 DPPLLTRYLRIHPQSWVHQ-IALRMEVLGCEAQD 2349
D P+ +Y+R++P+ W I +R+EVLGC+ D
Sbjct: 564 D-PIPAQYVRVYPERWSPAGIGMRLEVLGCDWTD 596
>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
Length = 901
Score = 164 bits (415), Expect = 9e-40
Identities = 117/334 (35%), Positives = 176/334 (52%), Gaps = 36/334 (10%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQY--GQWAPKLARLHYSGSINAW-----STKEPFSWIK 2091
+C PLGM SG I + QI+AS Y G+W P+ +RLH G N W S KE +++
Sbjct: 276 QCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNLDSNKE---YLQ 330
Query: 2092 VDLLAPMIIHGIKTQGA--RQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNV 2149
VDL ++ I TQGA R+ + Y+ + + S +G+ W YR VF N
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHK--VFQANN 388
Query: 2150 DSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDA 2207
D++ + N + P++ R++R+ P + LR+EL GC + CS LGM S I+D+
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2208 QITASSYFTNMFATWSPSKARLHLQGRSNAWR--PQVNNPKEWLQVDFQKTMKVTGVTTQ 2265
QI+ASS WSPS ARL + RS + PQ +EWLQVD V GV Q
Sbjct: 449 QISASS---TQEYLWSPSAARL-VSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQ 504
Query: 2266 G------VKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV---KVFQGNQDSFTPVVNSL 2316
G + ++ +V++F +S S +G W + Q+ + K+F+GN TP +
Sbjct: 505 GARGGDSITAVEARAFVRKFKVSYSLNGKDWE-YIQDPRTQQPKLFEGNMHYDTPDIRRF 563
Query: 2317 DPPLLTRYLRIHPQSWVHQ-IALRMEVLGCEAQD 2349
D P+ +Y+R++P+ W I +R+EVLGC+ D
Sbjct: 564 D-PIPAQYVRVYPERWSPAGIGMRLEVLGCDWTD 596
>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
Length = 931
Score = 164 bits (415), Expect = 9e-40
Identities = 117/334 (35%), Positives = 176/334 (52%), Gaps = 36/334 (10%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQY--GQWAPKLARLHYSGSINAW-----STKEPFSWIK 2091
+C PLGM SG I + QI+AS Y G+W P+ +RLH G N W S KE +++
Sbjct: 276 QCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNLDSNKE---YLQ 330
Query: 2092 VDLLAPMIIHGIKTQGA--RQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNV 2149
VDL ++ I TQGA R+ + Y+ + + S +G+ W YR VF N
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHK--VFQANN 388
Query: 2150 DSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDA 2207
D++ + N + P++ R++R+ P + LR+EL GC + CS LGM S I+D+
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2208 QITASSYFTNMFATWSPSKARLHLQGRSNAWR--PQVNNPKEWLQVDFQKTMKVTGVTTQ 2265
QI+ASS WSPS ARL + RS + PQ +EWLQVD V GV Q
Sbjct: 449 QISASS---TQEYLWSPSAARL-VSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQ 504
Query: 2266 G------VKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV---KVFQGNQDSFTPVVNSL 2316
G + ++ +V++F +S S +G W + Q+ + K+F+GN TP +
Sbjct: 505 GARGGDSITAVEARAFVRKFKVSYSLNGKDWE-YIQDPRTQQPKLFEGNMHYDTPDIRRF 563
Query: 2317 DPPLLTRYLRIHPQSWVHQ-IALRMEVLGCEAQD 2349
D P+ +Y+R++P+ W I +R+EVLGC+ D
Sbjct: 564 D-PIPAQYVRVYPERWSPAGIGMRLEVLGCDWTD 596
>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
Length = 906
Score = 164 bits (415), Expect = 9e-40
Identities = 117/334 (35%), Positives = 176/334 (52%), Gaps = 36/334 (10%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQY--GQWAPKLARLHYSGSINAW-----STKEPFSWIK 2091
+C PLGM SG I + QI+AS Y G+W P+ +RLH G N W S KE +++
Sbjct: 276 QCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNLDSNKE---YLQ 330
Query: 2092 VDLLAPMIIHGIKTQGA--RQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNV 2149
VDL ++ I TQGA R+ + Y+ + + S +G+ W YR VF N
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHK--VFQANN 388
Query: 2150 DSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDA 2207
D++ + N + P++ R++R+ P + LR+EL GC + CS LGM S I+D+
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2208 QITASSYFTNMFATWSPSKARLHLQGRSNAWR--PQVNNPKEWLQVDFQKTMKVTGVTTQ 2265
QI+ASS WSPS ARL + RS + PQ +EWLQVD V GV Q
Sbjct: 449 QISASS---TQEYLWSPSAARL-VSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQ 504
Query: 2266 G------VKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV---KVFQGNQDSFTPVVNSL 2316
G + ++ +V++F +S S +G W + Q+ + K+F+GN TP +
Sbjct: 505 GARGGDSITAVEARAFVRKFKVSYSLNGKDWE-YIQDPRTQQPKLFEGNMHYDTPDIRRF 563
Query: 2317 DPPLLTRYLRIHPQSWVHQ-IALRMEVLGCEAQD 2349
D P+ +Y+R++P+ W I +R+EVLGC+ D
Sbjct: 564 D-PIPAQYVRVYPERWSPAGIGMRLEVLGCDWTD 596
>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
Length = 926
Score = 164 bits (415), Expect = 9e-40
Identities = 117/334 (35%), Positives = 176/334 (52%), Gaps = 36/334 (10%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQY--GQWAPKLARLHYSGSINAW-----STKEPFSWIK 2091
+C PLGM SG I + QI+AS Y G+W P+ +RLH G N W S KE +++
Sbjct: 276 QCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNLDSNKE---YLQ 330
Query: 2092 VDLLAPMIIHGIKTQGA--RQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNV 2149
VDL ++ I TQGA R+ + Y+ + + S +G+ W YR VF N
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHK--VFQANN 388
Query: 2150 DSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDA 2207
D++ + N + P++ R++R+ P + LR+EL GC + CS LGM S I+D+
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2208 QITASSYFTNMFATWSPSKARLHLQGRSNAWR--PQVNNPKEWLQVDFQKTMKVTGVTTQ 2265
QI+ASS WSPS ARL + RS + PQ +EWLQVD V GV Q
Sbjct: 449 QISASS---TQEYLWSPSAARL-VSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQ 504
Query: 2266 G------VKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV---KVFQGNQDSFTPVVNSL 2316
G + ++ +V++F +S S +G W + Q+ + K+F+GN TP +
Sbjct: 505 GARGGDSITAVEARAFVRKFKVSYSLNGKDWE-YIQDPRTQQPKLFEGNMHYDTPDIRRF 563
Query: 2317 DPPLLTRYLRIHPQSWVHQ-IALRMEVLGCEAQD 2349
D P+ +Y+R++P+ W I +R+EVLGC+ D
Sbjct: 564 D-PIPAQYVRVYPERWSPAGIGMRLEVLGCDWTD 596
>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
Length = 609
Score = 160 bits (405), Expect = 1e-38
Identities = 109/321 (33%), Positives = 164/321 (51%), Gaps = 19/321 (5%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQYG-QWAPKLARLHYSGSINAWSTKEPF--SWIKVDLL 2095
KC LGM SG I QITAS QY W+ + +RL+Y N W+ E WI+VDL
Sbjct: 274 KCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPE--NGWTPGEDSYREWIQVDLG 331
Query: 2096 APMIIHGIKTQGARQKFSS--LYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSG 2153
+ + TQGA K + Y+ + I S +G+ W T + + L F GN + +
Sbjct: 332 LLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVL--FQGNTNPTD 389
Query: 2154 IKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDAQITA 2211
+ +F P+I R++R+ P + ++R E+ GC + CS LGM S ISD+QIT+
Sbjct: 390 VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITS 449
Query: 2212 SSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNP-KEWLQVDFQKTMKVTGVTTQGVKSL 2270
S+ W P RL A P ++ EWLQ+D + V G+ QG K
Sbjct: 450 SNQGDR---NWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHR 506
Query: 2271 LTSMYVKEFLISSSQDGHQWTLFFQNG--KVKVFQGNQDSFTPVVNSLDPPLLTRYLRIH 2328
+++++F I S +G W + + K K F+GN + TP + + P L TR++RI+
Sbjct: 507 ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF-PALSTRFIRIY 565
Query: 2329 PQSWVH-QIALRMEVLGCEAQ 2348
P+ H + LRME+LGCE +
Sbjct: 566 PERATHGGLGLRMELLGCEVE 586
Score = 103 bits (257), Expect = 2e-21
Identities = 62/159 (38%), Positives = 83/159 (52%), Gaps = 7/159 (4%)
Query: 2193 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 2252
C LGMES I QITASS ++ WS ++RL+ N W P ++ +EW+QVD
Sbjct: 275 CMEALGMESGEIHSDQITASSQYST---NWSAERSRLNYP--ENGWTPGEDSYREWIQVD 329
Query: 2253 FQKTMKVTGVTTQGVKSLLTSM--YVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFT 2310
VT V TQG S T YVK + I S +G W + K +FQGN +
Sbjct: 330 LGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTD 389
Query: 2311 PVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQD 2349
VV PL+TR++RI P +W I++R EV GC+ D
Sbjct: 390 VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITD 428
Score = 80.9 bits (198), Expect = 1e-14
Identities = 65/196 (33%), Positives = 97/196 (49%), Gaps = 19/196 (9%)
Query: 2028 GMSTLFLVYSNK-----CQTPLGMASGHIRDFQITASGQYGQ-WAPKLARLHYSGSINAW 2081
G+S F VY K C LGM SG I D QIT+S Q + W P+ RL S S W
Sbjct: 414 GISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRS--GW 471
Query: 2082 STKE-PFS----WIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRG 2136
+ P S W+++DL I+ GI QG + + + +++ +F I YS +G W+
Sbjct: 472 ALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMD 531
Query: 2137 NSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHP---THYSIRSTLRMELMGCDLNSC 2193
+S F GN + + F P + R+IR++P TH + LRMEL+GC++
Sbjct: 532 DSKRKAKSFEGNNNYDTPELRTF-PALSTRFIRIYPERATHGGLG--LRMELLGCEVEGG 588
Query: 2194 SMPLGMESKAISDAQI 2209
+ L E + D+ I
Sbjct: 589 TTVLATEKPTVIDSTI 604
>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
Length = 644
Score = 160 bits (405), Expect = 1e-38
Identities = 109/321 (33%), Positives = 164/321 (51%), Gaps = 19/321 (5%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQYG-QWAPKLARLHYSGSINAWSTKEPF--SWIKVDLL 2095
KC LGM SG I QITAS QY W+ + +RL+Y N W+ E WI+VDL
Sbjct: 274 KCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPE--NGWTPGEDSYREWIQVDLG 331
Query: 2096 APMIIHGIKTQGARQKFSS--LYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSG 2153
+ + TQGA K + Y+ + I S +G+ W T + + L F GN + +
Sbjct: 332 LLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVL--FQGNTNPTD 389
Query: 2154 IKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDAQITA 2211
+ +F P+I R++R+ P + ++R E+ GC + CS LGM S ISD+QIT+
Sbjct: 390 VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITS 449
Query: 2212 SSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNP-KEWLQVDFQKTMKVTGVTTQGVKSL 2270
S+ W P RL A P ++ EWLQ+D + V G+ QG K
Sbjct: 450 SNQGDR---NWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHR 506
Query: 2271 LTSMYVKEFLISSSQDGHQWTLFFQNG--KVKVFQGNQDSFTPVVNSLDPPLLTRYLRIH 2328
+++++F I S +G W + + K K F+GN + TP + + P L TR++RI+
Sbjct: 507 ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF-PALSTRFIRIY 565
Query: 2329 PQSWVH-QIALRMEVLGCEAQ 2348
P+ H + LRME+LGCE +
Sbjct: 566 PERATHGGLGLRMELLGCEVE 586
Score = 103 bits (257), Expect = 2e-21
Identities = 62/159 (38%), Positives = 83/159 (52%), Gaps = 7/159 (4%)
Query: 2193 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 2252
C LGMES I QITASS ++ WS ++RL+ N W P ++ +EW+QVD
Sbjct: 275 CMEALGMESGEIHSDQITASSQYST---NWSAERSRLNYP--ENGWTPGEDSYREWIQVD 329
Query: 2253 FQKTMKVTGVTTQGVKSLLTSM--YVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFT 2310
VT V TQG S T YVK + I S +G W + K +FQGN +
Sbjct: 330 LGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTD 389
Query: 2311 PVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQD 2349
VV PL+TR++RI P +W I++R EV GC+ D
Sbjct: 390 VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITD 428
Score = 76.3 bits (186), Expect = 3e-13
Identities = 61/179 (34%), Positives = 91/179 (50%), Gaps = 19/179 (10%)
Query: 2028 GMSTLFLVYSNK-----CQTPLGMASGHIRDFQITASGQYGQ-WAPKLARLHYSGSINAW 2081
G+S F VY K C LGM SG I D QIT+S Q + W P+ RL S S W
Sbjct: 414 GISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRS--GW 471
Query: 2082 STKE-PFS----WIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRG 2136
+ P S W+++DL I+ GI QG + + + +++ +F I YS +G W+
Sbjct: 472 ALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMD 531
Query: 2137 NSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHP---THYSIRSTLRMELMGCDLNS 2192
+S F GN + + F P + R+IR++P TH + LRMEL+GC++ +
Sbjct: 532 DSKRKAKSFEGNNNYDTPELRTF-PALSTRFIRIYPERATHGGLG--LRMELLGCEVEA 587
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 160 bits (405), Expect = 1e-38
Identities = 109/321 (33%), Positives = 164/321 (51%), Gaps = 19/321 (5%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQYG-QWAPKLARLHYSGSINAWSTKEPF--SWIKVDLL 2095
KC LGM SG I QITAS QY W+ + +RL+Y N W+ E WI+VDL
Sbjct: 274 KCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPE--NGWTPGEDSYREWIQVDLG 331
Query: 2096 APMIIHGIKTQGARQKFSS--LYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSG 2153
+ + TQGA K + Y+ + I S +G+ W T + + L F GN + +
Sbjct: 332 LLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVL--FQGNTNPTD 389
Query: 2154 IKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDAQITA 2211
+ +F P+I R++R+ P + ++R E+ GC + CS LGM S ISD+QIT+
Sbjct: 390 VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITS 449
Query: 2212 SSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNP-KEWLQVDFQKTMKVTGVTTQGVKSL 2270
S+ W P RL A P ++ EWLQ+D + V G+ QG K
Sbjct: 450 SNQGDR---NWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHR 506
Query: 2271 LTSMYVKEFLISSSQDGHQWTLFFQNG--KVKVFQGNQDSFTPVVNSLDPPLLTRYLRIH 2328
+++++F I S +G W + + K K F+GN + TP + + P L TR++RI+
Sbjct: 507 ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF-PALSTRFIRIY 565
Query: 2329 PQSWVH-QIALRMEVLGCEAQ 2348
P+ H + LRME+LGCE +
Sbjct: 566 PERATHGGLGLRMELLGCEVE 586
Score = 103 bits (257), Expect = 2e-21
Identities = 62/159 (38%), Positives = 83/159 (52%), Gaps = 7/159 (4%)
Query: 2193 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 2252
C LGMES I QITASS ++ WS ++RL+ N W P ++ +EW+QVD
Sbjct: 275 CMEALGMESGEIHSDQITASSQYST---NWSAERSRLNYP--ENGWTPGEDSYREWIQVD 329
Query: 2253 FQKTMKVTGVTTQGVKSLLTSM--YVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFT 2310
VT V TQG S T YVK + I S +G W + K +FQGN +
Sbjct: 330 LGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTD 389
Query: 2311 PVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQD 2349
VV PL+TR++RI P +W I++R EV GC+ D
Sbjct: 390 VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITD 428
Score = 76.3 bits (186), Expect = 3e-13
Identities = 61/179 (34%), Positives = 91/179 (50%), Gaps = 19/179 (10%)
Query: 2028 GMSTLFLVYSNK-----CQTPLGMASGHIRDFQITASGQYGQ-WAPKLARLHYSGSINAW 2081
G+S F VY K C LGM SG I D QIT+S Q + W P+ RL S S W
Sbjct: 414 GISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRS--GW 471
Query: 2082 STKE-PFS----WIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRG 2136
+ P S W+++DL I+ GI QG + + + +++ +F I YS +G W+
Sbjct: 472 ALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMD 531
Query: 2137 NSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHP---THYSIRSTLRMELMGCDLNS 2192
+S F GN + + F P + R+IR++P TH + LRMEL+GC++ +
Sbjct: 532 DSKRKAKSFEGNNNYDTPELRTF-PALSTRFIRIYPERATHGGLG--LRMELLGCEVEA 587
>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
Length = 555
Score = 134 bits (336), Expect = 1e-30
Identities = 96/271 (35%), Positives = 140/271 (51%), Gaps = 30/271 (11%)
Query: 2039 KCQTPLGMASGHIRDFQITASGQY--GQWAPKLARLHYSGSINAW-----STKEPFSWIK 2091
+C PLGM SG I + QI+AS Y G+W P+ +RLH G N W S KE +++
Sbjct: 276 QCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNLDSNKE---YLQ 330
Query: 2092 VDLLAPMIIHGIKTQGA--RQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNV 2149
VDL ++ I TQGA R+ + Y+ + + S +G+ W YR VF N
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHK--VFQANN 388
Query: 2150 DSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDA 2207
D++ + N + P++ R++R+ P + LR+EL GC + CS LGM S I+D+
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2208 QITASSYFTNMFATWSPSKARLHLQGRSNAWR--PQVNNPKEWLQVDFQKTMKVTGVTTQ 2265
QI+ASS WSPS ARL + RS + PQ +EWLQVD V GV Q
Sbjct: 449 QISASS---TQEYLWSPSAARL-VSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQ 504
Query: 2266 G------VKSLLTSMYVKEFLISSSQDGHQW 2290
G + ++ +V++F +S S +G W
Sbjct: 505 GARGGDSITAVEARAFVRKFKVSYSLNGKDW 535
Score = 128 bits (321), Expect = 8e-29
Identities = 67/159 (42%), Positives = 97/159 (61%), Gaps = 6/159 (3%)
Query: 2193 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 2252
C++PLGMES I++ QI+ASS +++ W+P ++RLH G N W P +++ KE+LQVD
Sbjct: 277 CNVPLGMESGRIANEQISASSTYSD--GRWTPQQSRLH--GDDNGWTPNLDSNKEYLQVD 332
Query: 2253 FQKTMKVTGVTTQGVKSLLTS--MYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFT 2310
+ +T + TQG S T YVK + + S +G W ++ KVFQ N D+
Sbjct: 333 LRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQANNDATE 392
Query: 2311 PVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQD 2349
V+N L PLLTR++RI PQ+W IALR+E+ GC D
Sbjct: 393 VVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTD 431
Score = 57.8 bits (138), Expect = 1e-07
Identities = 40/105 (38%), Positives = 54/105 (51%), Gaps = 14/105 (13%)
Query: 2040 CQTPLGMASGHIRDFQITASG-QYGQWAPKLARLHYSGSINAWSTKEPFS-----WIKVD 2093
C LGM SG I D QI+AS Q W+P ARL S S W + P + W++VD
Sbjct: 434 CSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRS--GWFPRIPQAQPGEEWLQVD 491
Query: 2094 LLAPMIIHGIKTQGARQKFS------SLYISQFIIMYSLDGKKWQ 2132
L P + G+ QGAR S ++ +F + YSL+GK W+
Sbjct: 492 LGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWE 536
>gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo
sapiens]
Length = 775
Score = 120 bits (301), Expect = 2e-26
Identities = 66/178 (37%), Positives = 97/178 (54%), Gaps = 9/178 (5%)
Query: 2176 SIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASSYF-----TNMFATWSPSKARLH 2230
S+ L L + C LGMES I+D QITASS T +W P KARL
Sbjct: 275 SVVGHLSTSLFTFKTSGCYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLK 334
Query: 2231 LQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQW 2290
G W + +WLQ+D K K+TG+ T G + + YV + I S DG +W
Sbjct: 335 KPGPP--WAAFATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKW 392
Query: 2291 TLFFQNG--KVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE 2346
T++ + G + K+FQGN+D V N+ PP++ R++R++P W +IA++ME+LGC+
Sbjct: 393 TVYREPGVEQDKIFQGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGCQ 450
Score = 109 bits (273), Expect = 3e-23
Identities = 65/168 (38%), Positives = 89/168 (52%), Gaps = 9/168 (5%)
Query: 2030 STLFLVYSNKCQTPLGMASGHIRDFQITAS---------GQYGQWAPKLARLHYSGSINA 2080
++LF ++ C LGM SG I D QITAS GQ W PK ARL G A
Sbjct: 282 TSLFTFKTSGCYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGPPWA 341
Query: 2081 WSTKEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTG 2140
+ + W+++DL I GI T G+ + Y+S + I+YS DG+KW YR
Sbjct: 342 AFATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYREPGVE 401
Query: 2141 TLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGC 2188
+F GN D N F PPIIAR+IR++PT + + ++MEL+GC
Sbjct: 402 QDKIFQGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGC 449
>gi|27735143 discoidin, CUB and LCCL domain containing 1 [Homo
sapiens]
Length = 539
Score = 110 bits (275), Expect = 2e-23
Identities = 62/165 (37%), Positives = 94/165 (56%), Gaps = 13/165 (7%)
Query: 2191 NSCSMPLGMESKAISDAQITASSYFTNMFAT-----WSPSKARLHLQGRSNAWRPQVNN- 2244
N CS L E D QI ASS + ++ + WSP +ARL QG S A NN
Sbjct: 253 NGCSRSLSFEP----DGQIRASSSWQSVNESGDQVHWSPGQARLQDQGPSWASGDSSNNH 308
Query: 2245 -PKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLF--FQNGKVKV 2301
P+EWL++D + K+TG+ T G + YVK F+++ + +W + N + KV
Sbjct: 309 KPREWLEIDLGEKKKITGIRTTGSTQSNFNFYVKSFVMNFKNNNSKWKTYKGIVNNEEKV 368
Query: 2302 FQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE 2346
FQGN + PV N+ PP++ RY+R+ PQ+W +IAL++E++GC+
Sbjct: 369 FQGNSNFRDPVQNNFIPPIVARYVRVVPQTWHQRIALKVELIGCQ 413
Score = 90.1 bits (222), Expect = 2e-17
Identities = 55/167 (32%), Positives = 83/167 (49%), Gaps = 9/167 (5%)
Query: 2033 FLVYSNKCQTPLGMA-SGHIRDFQ----ITASGQYGQWAPKLARLHYSG----SINAWST 2083
FL SN C L G IR + SG W+P ARL G S ++ +
Sbjct: 248 FLFTSNGCSRSLSFEPDGQIRASSSWQSVNESGDQVHWSPGQARLQDQGPSWASGDSSNN 307
Query: 2084 KEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLM 2143
+P W+++DL I GI+T G+ Q + Y+ F++ + + KW+TY+G
Sbjct: 308 HKPREWLEIDLGEKKKITGIRTTGSTQSNFNFYVKSFVMNFKNNNSKWKTYKGIVNNEEK 367
Query: 2144 VFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDL 2190
VF GN + N F PPI+ARY+R+ P + R L++EL+GC +
Sbjct: 368 VFQGNSNFRDPVQNNFIPPIVARYVRVVPQTWHQRIALKVELIGCQI 414
>gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo
sapiens]
Length = 1158
Score = 102 bits (255), Expect = 3e-21
Identities = 54/163 (33%), Positives = 86/163 (52%), Gaps = 10/163 (6%)
Query: 2196 PLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSN-------AWRPQVNNPKEW 2248
P+GMES I D QI ASS + + RL++Q + AW + + +W
Sbjct: 387 PIGMESHRIEDNQIRASSMLRHGLGA---QRGRLNMQTGATEDDYYDGAWCAEDDARTQW 443
Query: 2249 LQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDS 2308
++VD ++T + TGV TQG S + +V F + S D W ++ + F GN D
Sbjct: 444 IEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDK 503
Query: 2309 FTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQDLY 2351
TPV++ L P++ R++RI+P +W + +R+EVLGC +Y
Sbjct: 504 DTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVAPVY 546
Score = 63.9 bits (154), Expect = 2e-09
Identities = 46/162 (28%), Positives = 75/162 (46%), Gaps = 13/162 (8%)
Query: 2039 KCQTPLGMASGHIRDFQITASG--QYGQWAPKLARLHYSGSIN------AWSTKEPF--S 2088
KC P+GM S I D QI AS ++G A + +G+ AW ++
Sbjct: 384 KCP-PIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQ 442
Query: 2089 WIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGN 2148
WI+VD G+ TQG +++ F + +S D + W Y M F GN
Sbjct: 443 WIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEE--MTFHGN 500
Query: 2149 VDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDL 2190
VD + P++AR+IR++P ++ +R+E++GC +
Sbjct: 501 VDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSV 542
>gi|223005864 carboxypeptidase X (M14 family), member 2 [Homo sapiens]
Length = 756
Score = 101 bits (252), Expect = 8e-21
Identities = 58/170 (34%), Positives = 88/170 (51%), Gaps = 12/170 (7%)
Query: 2189 DLNSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSN-------AWRPQ 2241
D+ PLG+E+ I+D Q+ AS+ + RL++Q N AW
Sbjct: 131 DVRESCPPLGLETLKITDFQLHASTVKRYGLGA---HRGRLNIQAGINENDFYDGAWCAG 187
Query: 2242 VNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKV 2301
N+ ++W++VD ++ + TGV TQG SL S +V + + S D H W +
Sbjct: 188 RNDLQQWIEVDARRLTRFTGVITQGRNSLWLSDWVTSYKVMVSNDSHTWVTVKNGSGDMI 247
Query: 2302 FQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVH--QIALRMEVLGCEAQD 2349
F+GN + PV+N L P++ RY+RI+PQSW I +RME+LGC D
Sbjct: 248 FEGNSEKEIPVLNELPVPMVARYIRINPQSWFDNGSICMRMEILGCPLPD 297
Score = 65.1 bits (157), Expect = 8e-10
Identities = 51/161 (31%), Positives = 78/161 (48%), Gaps = 16/161 (9%)
Query: 2043 PLGMASGHIRDFQITASG--QYGQWAPKLARLHYSGSIN-------AWST--KEPFSWIK 2091
PLG+ + I DFQ+ AS +YG A + RL+ IN AW + WI+
Sbjct: 138 PLGLETLKITDFQLHASTVKRYGLGAHR-GRLNIQAGINENDFYDGAWCAGRNDLQQWIE 196
Query: 2092 VDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDS 2151
VD G+ TQG + S +++ + +M S D W T + S M+F GN +
Sbjct: 197 VDARRLTRFTGVITQGRNSLWLSDWVTSYKVMVSNDSHTWVTVKNGSGD--MIFEGNSEK 254
Query: 2152 SGIKHNIFNPPIIARYIRLHPTHYSIRST--LRMELMGCDL 2190
N P++ARYIR++P + + +RME++GC L
Sbjct: 255 EIPVLNELPVPMVARYIRINPQSWFDNGSICMRMEILGCPL 295
>gi|10835083 X-linked juvenile retinoschisis protein precursor [Homo
sapiens]
Length = 224
Score = 95.9 bits (237), Expect = 4e-19
Identities = 50/154 (32%), Positives = 89/154 (57%), Gaps = 6/154 (3%)
Query: 2196 PLGMESKAISDAQITASS--YFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDF 2253
PLG ES ++ QIT S+ + +++W+ +KARL+ QG AW + + +WLQ+D
Sbjct: 68 PLGFESGEVTPDQITCSNPEQYVGWYSSWTANKARLNSQGFGCAWLSKFQDSSQWLQIDL 127
Query: 2254 QKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFF--QNGKVKVFQGNQDSFTP 2311
++ ++G+ TQG + ++ ++ + D +++ Q G +VF GN D +
Sbjct: 128 KEIKVISGILTQGRCDI--DEWMTKYSVQYRTDERLNWIYYKDQTGNNRVFYGNSDRTST 185
Query: 2312 VVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGC 2345
V N L PP+++R++R+ P W +IA+RME+L C
Sbjct: 186 VQNLLRPPIISRFIRLIPLGWHVRIAIRMELLEC 219
Score = 92.4 bits (228), Expect = 5e-18
Identities = 57/170 (33%), Positives = 85/170 (50%), Gaps = 10/170 (5%)
Query: 2027 AGMSTLFLVYSNKCQTPLGMASGHIRDFQITAS------GQYGQWAPKLARLHYSGSINA 2080
AG ++L + PLG SG + QIT S G Y W ARL+ G A
Sbjct: 52 AGATSLDCIPECPYHKPLGFESGEVTPDQITCSNPEQYVGWYSSWTANKARLNSQGFGCA 111
Query: 2081 WSTK--EPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNS 2138
W +K + W+++DL +I GI TQG +++++ + Y D + Y +
Sbjct: 112 WLSKFQDSSQWLQIDLKEIKVISGILTQGRCD--IDEWMTKYSVQYRTDERLNWIYYKDQ 169
Query: 2139 TGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGC 2188
TG VF+GN D + N+ PPII+R+IRL P + +R +RMEL+ C
Sbjct: 170 TGNNRVFYGNSDRTSTVQNLLRPPIISRFIRLIPLGWHVRIAIRMELLEC 219
>gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapiens]
Length = 1331
Score = 84.0 bits (206), Expect = 2e-15
Identities = 49/155 (31%), Positives = 82/155 (52%), Gaps = 10/155 (6%)
Query: 2193 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 2252
C PL +S A S +++ ++SP A+++ +G + W P ++ +WLQVD
Sbjct: 35 CDEPL------VSGLPHVAFSSSSSISGSYSPGYAKINKRGGAGGWSPSDSDHYQWLQVD 88
Query: 2253 FQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPV 2312
F +++ + TQG S +S +V ++ + S G W + Q+G + F GN +S V
Sbjct: 89 FGNRKQISAIATQGRYS--SSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVV 146
Query: 2313 VNSLDPPLLTRYLRIHPQSW--VHQIALRMEVLGC 2345
+ L P++ RY+RI P W +I LR+EV GC
Sbjct: 147 RHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGC 181
Score = 77.4 bits (189), Expect = 2e-13
Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 10/156 (6%)
Query: 2037 SNKCQTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKEP--FSWIKVDL 2094
S KC PL H+ ++S G ++P A+++ G WS + + W++VD
Sbjct: 32 SQKCDEPLVSGLPHVAFS--SSSSISGSYSPGYAKINKRGGAGGWSPSDSDHYQWLQVDF 89
Query: 2095 LAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGI 2154
I I TQG SS +++Q+ ++YS G+ W+ Y + G + F GN++S G+
Sbjct: 90 GNRKQISAIATQGRYS--SSDWVTQYRMLYSDTGRNWKPY--HQDGNIWAFPGNINSDGV 145
Query: 2155 KHNIFNPPIIARYIRLHPTHYS--IRSTLRMELMGC 2188
+ PIIARY+R+ P ++ R LR+E+ GC
Sbjct: 146 VRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGC 181
>gi|9994201 carboxypeptidase X, member 1 precursor [Homo sapiens]
Length = 734
Score = 82.4 bits (202), Expect = 5e-15
Identities = 54/165 (32%), Positives = 81/165 (49%), Gaps = 14/165 (8%)
Query: 2196 PLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGR-------SNAWRPQVNNPKEW 2248
PLG+ES +SD+++ ASS + F P + RL++Q AW + + W
Sbjct: 117 PLGLESLRVSDSRLEASS--SQSFGL-GPHRGRLNIQSGLEDGDLYDGAWCAEEQDADPW 173
Query: 2249 LQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQW--TLFFQNGKVKVFQGNQ 2306
QVD + +GV TQG S+ +V + + S D W + +G VF N
Sbjct: 174 FQVDAGHPTRFSGVITQGRNSVWRYDWVTSYKVQFSNDSRTWWGSRNHSSGMDAVFPANS 233
Query: 2307 DSFTPVVNSLDPPLLTRYLRIHPQSWVHQIA--LRMEVLGCEAQD 2349
D TPV+N L P + R++R+ PQ+W+ A LR E+L C D
Sbjct: 234 DPETPVLNLLPEPQVARFIRLLPQTWLQGGAPCLRAEILACPVSD 278
Score = 57.4 bits (137), Expect = 2e-07
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 12/161 (7%)
Query: 2043 PLGMASGHIRDFQITASG-QYGQWAPKLARLHYSGSIN-------AWSTKEPFS--WIKV 2092
PLG+ S + D ++ AS Q P RL+ + AW +E + W +V
Sbjct: 117 PLGLESLRVSDSRLEASSSQSFGLGPHRGRLNIQSGLEDGDLYDGAWCAEEQDADPWFQV 176
Query: 2093 DLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSS 2152
D P G+ TQG + +++ + + +S D + W R +S+G VF N D
Sbjct: 177 DAGHPTRFSGVITQGRNSVWRYDWVTSYKVQFSNDSRTWWGSRNHSSGMDAVFPANSDPE 236
Query: 2153 GIKHNIFNPPIIARYIRLHPTHY--SIRSTLRMELMGCDLN 2191
N+ P +AR+IRL P + LR E++ C ++
Sbjct: 237 TPVLNLLPEPQVARFIRLLPQTWLQGGAPCLRAEILACPVS 277
>gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sapiens]
Length = 1235
Score = 80.1 bits (196), Expect = 2e-14
Identities = 50/155 (32%), Positives = 78/155 (50%), Gaps = 10/155 (6%)
Query: 2193 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 2252
C PL A+ A ++SS + ++ P ARL+ + + W P V+N +WLQ+D
Sbjct: 6 CDDPL---VSALPQASFSSSS---ELSSSHGPGFARLNRRDGAGGWSPLVSNKYQWLQID 59
Query: 2253 FQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPV 2312
+ M+VT V TQG +S +V +L+ S G W + Q + F GN ++ + V
Sbjct: 60 LGERMEVTAVATQG--GYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWGFSGNANADSVV 117
Query: 2313 VNSLDPPLLTRYLRIHPQSW--VHQIALRMEVLGC 2345
L P + R+LR P W +I +R+EV GC
Sbjct: 118 YYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGC 152
Score = 58.9 bits (141), Expect = 6e-08
Identities = 36/130 (27%), Positives = 64/130 (49%), Gaps = 8/130 (6%)
Query: 2067 PKLARLHYSGSINAWS--TKEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMY 2124
P ARL+ WS + W+++DL M + + TQG SS +++ +++M+
Sbjct: 31 PGFARLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYG--SSNWVTSYLLMF 88
Query: 2125 SLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSI--RSTLR 2182
S G W+ YR + + F GN ++ + + P I AR++R P ++ R +R
Sbjct: 89 SDSGWNWKQYRQEDS--IWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMR 146
Query: 2183 MELMGCDLNS 2192
+E+ GC S
Sbjct: 147 IEVFGCAYRS 156
>gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sapiens]
Length = 1308
Score = 80.1 bits (196), Expect = 2e-14
Identities = 50/155 (32%), Positives = 78/155 (50%), Gaps = 10/155 (6%)
Query: 2193 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 2252
C PL A+ A ++SS + ++ P ARL+ + + W P V+N +WLQ+D
Sbjct: 31 CDDPL---VSALPQASFSSSS---ELSSSHGPGFARLNRRDGAGGWSPLVSNKYQWLQID 84
Query: 2253 FQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPV 2312
+ M+VT V TQG +S +V +L+ S G W + Q + F GN ++ + V
Sbjct: 85 LGERMEVTAVATQG--GYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWGFSGNANADSVV 142
Query: 2313 VNSLDPPLLTRYLRIHPQSW--VHQIALRMEVLGC 2345
L P + R+LR P W +I +R+EV GC
Sbjct: 143 YYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGC 177
Score = 58.9 bits (141), Expect = 6e-08
Identities = 36/130 (27%), Positives = 64/130 (49%), Gaps = 8/130 (6%)
Query: 2067 PKLARLHYSGSINAWS--TKEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMY 2124
P ARL+ WS + W+++DL M + + TQG SS +++ +++M+
Sbjct: 56 PGFARLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYG--SSNWVTSYLLMF 113
Query: 2125 SLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSI--RSTLR 2182
S G W+ YR + + F GN ++ + + P I AR++R P ++ R +R
Sbjct: 114 SDSGWNWKQYRQEDS--IWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMR 171
Query: 2183 MELMGCDLNS 2192
+E+ GC S
Sbjct: 172 IEVFGCAYRS 181
>gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2
[Homo sapiens]
Length = 1207
Score = 77.4 bits (189), Expect = 2e-13
Identities = 48/155 (30%), Positives = 80/155 (51%), Gaps = 10/155 (6%)
Query: 2193 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 2252
C PL + A+ + ++SS + ++ P +RL+ + + W P V+N +WLQ+D
Sbjct: 31 CDSPL---ASALPRSSFSSSS---ELSSSHGPGFSRLNRRDGAGGWTPLVSNKYQWLQID 84
Query: 2253 FQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPV 2312
+ M+VT V TQG +S +V +L+ S G W + + + F GN ++ + V
Sbjct: 85 LGERMEVTAVATQG--GYGSSDWVTSYLLMFSDGGRNWKQYRREESIWGFPGNTNADSVV 142
Query: 2313 VNSLDPPLLTRYLRIHPQSW--VHQIALRMEVLGC 2345
L PP R+LR P +W +I +R+EV GC
Sbjct: 143 HYRLQPPFEARFLRFLPLAWNPRGRIGMRIEVYGC 177
Score = 63.2 bits (152), Expect = 3e-09
Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 10/157 (6%)
Query: 2040 CQTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWS--TKEPFSWIKVDLLAP 2097
C +PL AS R ++S P +RL+ W+ + W+++DL
Sbjct: 31 CDSPL--ASALPRSSFSSSSELSSSHGPGFSRLNRRDGAGGWTPLVSNKYQWLQIDLGER 88
Query: 2098 MIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHN 2157
M + + TQG SS +++ +++M+S G+ W+ YR + + F GN ++ + H
Sbjct: 89 MEVTAVATQGGYG--SSDWVTSYLLMFSDGGRNWKQYRREES--IWGFPGNTNADSVVHY 144
Query: 2158 IFNPPIIARYIRLHPTHYSIRST--LRMELMGCDLNS 2192
PP AR++R P ++ R +R+E+ GC S
Sbjct: 145 RLQPPFEARFLRFLPLAWNPRGRIGMRIEVYGCAYKS 181
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,118,511
Number of Sequences: 37866
Number of extensions: 4358020
Number of successful extensions: 11467
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 10797
Number of HSP's gapped (non-prelim): 272
length of query: 2351
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2232
effective length of database: 13,741,464
effective search space: 30670947648
effective search space used: 30670947648
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.