Search of human proteins with 4503391

Search of human proteins with 4503391

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503391 dopamine receptor D5 [Homo sapiens]
         (477 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503391 dopamine receptor D5 [Homo sapiens]                        986   0.0  
gi|4503383 dopamine receptor D1 [Homo sapiens]                        483   e-136
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                  223   2e-58
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]         216   5e-56
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]         213   4e-55
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]        212   5e-55
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]         211   9e-55
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]         211   2e-54
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]         211   2e-54
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]         211   2e-54
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]      205   8e-53
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    201   1e-51
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    201   1e-51
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    201   1e-51
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    201   1e-51
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]           197   2e-50
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]            197   2e-50
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]                197   2e-50
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]               189   4e-48
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                187   2e-47
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   179   5e-45
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi...   178   8e-45
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]   177   2e-44
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]   177   2e-44
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]    177   2e-44
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   176   3e-44
gi|21264324 trace amine associated receptor 1 [Homo sapiens]          169   5e-42
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]            166   3e-41
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]             161   1e-39
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap...   158   9e-39

>gi|4503391 dopamine receptor D5 [Homo sapiens]
          Length = 477

 Score =  986 bits (2549), Expect = 0.0
 Identities = 477/477 (100%), Positives = 477/477 (100%)

Query: 1   MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVL 60
           MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVL
Sbjct: 1   MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVL 60

Query: 61  VCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFD 120
           VCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFD
Sbjct: 61  VCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFD 120

Query: 121 IMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNW 180
           IMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNW
Sbjct: 121 IMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNW 180

Query: 181 HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI 240
           HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI
Sbjct: 181 HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI 240

Query: 241 MIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSV 300
           MIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSV
Sbjct: 241 MIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSV 300

Query: 301 IMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA 360
           IMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA
Sbjct: 301 IMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA 360

Query: 361 FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP 420
           FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP
Sbjct: 361 FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP 420

Query: 421 GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH 477
           GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
Sbjct: 421 GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH 477


>gi|4503383 dopamine receptor D1 [Homo sapiens]
          Length = 446

 Score =  483 bits (1242), Expect = e-136
 Identities = 261/450 (58%), Positives = 329/450 (73%), Gaps = 40/450 (8%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           +++TAC L+LLI+ TLLGN LVCAA++R RHLR+ +TN F++SLAVSDL VA+LVMPWKA
Sbjct: 23  RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKA 82

Query: 100 VAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALV 159
           VAE+AG+WPFG+FC++WVAFDIMCSTASILNLCVISVDRYWAIS PFRY+RKMT + A +
Sbjct: 83  VAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFI 142

Query: 160 MVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDS 219
           ++ +AWTLS+LISFIPVQL+WH+ +  S      P++  N T   E         +NCDS
Sbjct: 143 LISVAWTLSVLISFIPVQLSWHKAKPTS------PSD-GNATSLAE-------TIDNCDS 188

Query: 220 SLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAA-- 277
           SL+RTYAISSS+ISFYIPVAIMIVTYTRIYRIAQ QIRRI++LERAA HA++C+++    
Sbjct: 189 SLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNG 248

Query: 278 ----CA-PDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAG 332
               C+ P++S + S K+ETKVLKTLSVIMGVFVCCWLPFFILNC++PFC G  E  P  
Sbjct: 249 KPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFC-GSGETQPF- 306

Query: 333 FPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRT--PVETVNIS 390
             C+   TFDVFVWFGWANSSLNP+IYAFNADF+K F+ LLGC   C  T   +ETV+I+
Sbjct: 307 --CIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSIN 364

Query: 391 NE---LISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDG 447
           N    + S + +           ++++P+AV  G+ E    EE     R  +  + SP  
Sbjct: 365 NNGAAMFSSHHEPRGSISKECNLVYLIPHAV--GSSEDLKKEEAAGIARPLE--KLSP-- 418

Query: 448 DPVAESVWELDCEGEISLDKITPFTPNGFH 477
              A SV  LD + ++SL+KI P T NG H
Sbjct: 419 ---ALSV-ILDYDTDVSLEKIQPITQNGQH 444


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score =  223 bits (569), Expect = 2e-58
 Identities = 137/366 (37%), Positives = 203/366 (55%), Gaps = 60/366 (16%)

Query: 46  LLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAG 105
           L+ L+++  + GNVLV  AI ++  L+  +TN+FI+SLA +DL + LLV+P+ A   V G
Sbjct: 64  LMALIVLLIVAGNVLVIVAIAKTPRLQT-LTNLFIMSLASADLVMGLLVVPFGATIVVWG 122

Query: 106 YWPFGA-FCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLA 164
            W +G+ FC++W + D++C TASI  LCVI++DRY AI+ PFRY+  +T+  A  +V   
Sbjct: 123 RWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTV 182

Query: 165 WTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRT 224
           W +S L+SF+P+ ++W R ++      D      N             + + CD   NR 
Sbjct: 183 WAISALVSFLPILMHWWRAES------DEARRCYN-------------DPKCCDFVTNRA 223

Query: 225 YAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLER------AAEHAQS------- 271
           YAI+SS++SFY+P+ IM   Y R++R AQ Q+++I S ER      A   + S       
Sbjct: 224 YAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAP 283

Query: 272 --------CRSSAACAPDTSLRASIK--------KETKVLKTLSVIMGVFVCCWLPFFIL 315
                     ++AA AP  + RA  +        +E K LKTL +IMGVF  CWLPFF+ 
Sbjct: 284 APPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLA 343

Query: 316 NCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGC 375
           N +  F   H E        V +  F  F W G+ANS+ NP+IY  + DF+K F  LL C
Sbjct: 344 NVVKAF---HRE-------LVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCC 393

Query: 376 SHFCSR 381
           +   +R
Sbjct: 394 ARRAAR 399


>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
          Length = 428

 Score =  216 bits (549), Expect = 5e-56
 Identities = 134/382 (35%), Positives = 196/382 (51%), Gaps = 39/382 (10%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           +VV    L+ +I+  +LGN+LV  A+   R LR   TN FIVSLA +DL V++LVMP+ A
Sbjct: 19  KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGA 78

Query: 100 VAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAI-SRPFRYKRKMTQRMA 157
           +  V   W +G  FC V  + D++ +TASI +LC IS+DRY+AI  +P  Y+ KMT    
Sbjct: 79  IELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138

Query: 158 LVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENC 217
            +M+G  W +   ISF+P+   W              NN+      E+  +  + N+  C
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGW--------------NNIGIIDLIEKRKFNQNSNSTYC 184

Query: 218 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAA 277
              +N+ YAI+ S+++FYIP  +M++ Y RIY  A+    +I  L+RA   ++S   SA 
Sbjct: 185 VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSA- 243

Query: 278 CAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVS 337
              D      ++ ETK  KTL +IMG F  CW PFF+ N + PF      G         
Sbjct: 244 ---DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPG--------- 291

Query: 338 ETTFDVFVWFGWANSSLNPVIYAF-NADFQKVFAQLLGC--------SHFCSRTPVETVN 388
              +  F+W G+ NS LNP +YAF N  F++ F  +L C        S      P  T  
Sbjct: 292 -QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTT 350

Query: 389 ISNELISYNQDIVFHKEIAAAY 410
           I+        D +F ++I A Y
Sbjct: 351 INGSTHVLRTDFLFDRDILARY 372


>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
          Length = 387

 Score =  213 bits (541), Expect = 4e-55
 Identities = 136/393 (34%), Positives = 201/393 (51%), Gaps = 42/393 (10%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           +VV    L+ +I+  +LGN+LV  A+   R LR   TN FIVSLA +DL V++LVMP+ A
Sbjct: 19  KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGA 78

Query: 100 VAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAI-SRPFRYKRKMTQRMA 157
           +  V   W +G  FC V  + D++ +TASI +LC IS+DRY+AI  +P  Y+ KMT    
Sbjct: 79  IELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138

Query: 158 LVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENC 217
            +M+G  W +   ISF+P+   W              NN+      E+  +  + N+  C
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGW--------------NNIGIIDLIEKRKFNQNSNSTYC 184

Query: 218 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAA 277
              +N+ YAI+ S+++FYIP  +M++ Y RIY  A+    +I  L+RA   ++S   SA 
Sbjct: 185 VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSA- 243

Query: 278 CAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVS 337
              D      ++ ETK  KTL +IMG F  CW PFF+ N + PF      G         
Sbjct: 244 ---DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPG--------- 291

Query: 338 ETTFDVFVWFGWANSSLNPVIYAF-NADFQKVFAQLLGCSHFCSRTP----------VET 386
              +  F+W G+ NS LNP +YAF N  F++ F  +L C     R P            T
Sbjct: 292 -QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTT 350

Query: 387 VNISNELISYN-QDIVFHKEIAAAYIHMMPNAV 418
           +N S  ++ Y       H+E+    IH  P ++
Sbjct: 351 INGSTHVLRYTVLHRGHHQELEKLPIHNDPESL 383


>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
          Length = 402

 Score =  212 bits (540), Expect = 5e-55
 Identities = 129/352 (36%), Positives = 192/352 (54%), Gaps = 27/352 (7%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           +VV    L+ +I+  +LGN+LV  A+   R LR   TN FIVSLA +DL V++LVMP+ A
Sbjct: 19  KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGA 78

Query: 100 VAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAI-SRPFRYKRKMTQRMA 157
           +  V   W +G  FC V  + D++ +TASI +LC IS+DRY+AI  +P  Y+ KMT    
Sbjct: 79  IELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138

Query: 158 LVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNL-----ANWTPWEEDFWEPDV 212
            +M+G  W +   ISF+P+   W+     + G +DL  +L      ++   E+  +  + 
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGWN-----NIGIIDLERSLNQGLGQDFHAIEKRKFNQNS 193

Query: 213 NAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSC 272
           N+  C   +N+ YAI+ S+++FYIP  +M++ Y RIY  A+    +I  L+RA   ++S 
Sbjct: 194 NSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESR 253

Query: 273 RSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAG 332
             SA    D      ++ ETK  KTL +IMG F  CW PFF+ N + PF      G    
Sbjct: 254 PQSA----DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPG---- 305

Query: 333 FPCVSETTFDVFVWFGWANSSLNPVIYAF-NADFQKVFAQLLGCSHFCSRTP 383
                   +  F+W G+ NS LNP +YAF N  F++ F  +L C     R P
Sbjct: 306 ------QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP 351


>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
          Length = 378

 Score =  211 bits (538), Expect = 9e-55
 Identities = 133/387 (34%), Positives = 201/387 (51%), Gaps = 34/387 (8%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           +VV    L+ +I+  +LGN+LV  A+   R LR   TN FIVSLA +DL V++LVMP+ A
Sbjct: 19  KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGA 78

Query: 100 VAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAI-SRPFRYKRKMTQRMA 157
           +  V   W +G  FC V  + D++ +TASI +LC IS+DRY+AI  +P  Y+ KMT    
Sbjct: 79  IELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138

Query: 158 LVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENC 217
            +M+G  W +   ISF+P+   W              NN+      E+  +  + N+  C
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGW--------------NNIGIIDLIEKRKFNQNSNSTYC 184

Query: 218 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAA 277
              +N+ YAI+ S+++FYIP  +M++ Y RIY  A+    +I  L+RA   ++S   SA 
Sbjct: 185 VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSA- 243

Query: 278 CAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVS 337
              D      ++ ETK  KTL +IMG F  CW PFF+ N + PF      G         
Sbjct: 244 ---DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPG--------- 291

Query: 338 ETTFDVFVWFGWANSSLNPVIYAF-NADFQKVFAQLLGCSHFCSRTPV---ETVNISNEL 393
              +  F+W G+ NS LNP +YAF N  F++ F  +L C     R P    +TV  S   
Sbjct: 292 -QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTT 350

Query: 394 ISYNQDIVFHKEIAAAYIHMMPNAVTP 420
           I+ +  ++      ++++ +  N   P
Sbjct: 351 INGSTHVLSGCSPVSSFLLLFCNRPVP 377


>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
          Length = 359

 Score =  211 bits (536), Expect = 2e-54
 Identities = 127/347 (36%), Positives = 185/347 (53%), Gaps = 31/347 (8%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           +VV    L+ +I+  +LGN+LV  A+   R LR   TN FIVSLA +DL V++LVMP+ A
Sbjct: 19  KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGA 78

Query: 100 VAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAI-SRPFRYKRKMTQRMA 157
           +  V   W +G  FC V  + D++ +TASI +LC IS+DRY+AI  +P  Y+ KMT    
Sbjct: 79  IELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138

Query: 158 LVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENC 217
            +M+G  W +   ISF+P+   W              NN+      E+  +  + N+  C
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGW--------------NNIGIIDLIEKRKFNQNSNSTYC 184

Query: 218 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAA 277
              +N+ YAI+ S+++FYIP  +M++ Y RIY  A+    +I  L+RA   ++S   SA 
Sbjct: 185 VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSA- 243

Query: 278 CAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVS 337
              D      ++ ETK  KTL +IMG F  CW PFF+ N + PF      G         
Sbjct: 244 ---DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPG--------- 291

Query: 338 ETTFDVFVWFGWANSSLNPVIYAF-NADFQKVFAQLLGCSHFCSRTP 383
              +  F+W G+ NS LNP +YAF N  F++ F  +L C     R P
Sbjct: 292 -QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP 337


>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
          Length = 360

 Score =  211 bits (536), Expect = 2e-54
 Identities = 127/347 (36%), Positives = 185/347 (53%), Gaps = 31/347 (8%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           +VV    L+ +I+  +LGN+LV  A+   R LR   TN FIVSLA +DL V++LVMP+ A
Sbjct: 19  KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGA 78

Query: 100 VAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAI-SRPFRYKRKMTQRMA 157
           +  V   W +G  FC V  + D++ +TASI +LC IS+DRY+AI  +P  Y+ KMT    
Sbjct: 79  IELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138

Query: 158 LVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENC 217
            +M+G  W +   ISF+P+   W              NN+      E+  +  + N+  C
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGW--------------NNIGIIDLIEKRKFNQNSNSTYC 184

Query: 218 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAA 277
              +N+ YAI+ S+++FYIP  +M++ Y RIY  A+    +I  L+RA   ++S   SA 
Sbjct: 185 VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSA- 243

Query: 278 CAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVS 337
              D      ++ ETK  KTL +IMG F  CW PFF+ N + PF      G         
Sbjct: 244 ---DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPG--------- 291

Query: 338 ETTFDVFVWFGWANSSLNPVIYAF-NADFQKVFAQLLGCSHFCSRTP 383
              +  F+W G+ NS LNP +YAF N  F++ F  +L C     R P
Sbjct: 292 -QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP 337


>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
          Length = 388

 Score =  211 bits (536), Expect = 2e-54
 Identities = 127/347 (36%), Positives = 185/347 (53%), Gaps = 31/347 (8%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           +VV    L+ +I+  +LGN+LV  A+   R LR   TN FIVSLA +DL V++LVMP+ A
Sbjct: 19  KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGA 78

Query: 100 VAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAI-SRPFRYKRKMTQRMA 157
           +  V   W +G  FC V  + D++ +TASI +LC IS+DRY+AI  +P  Y+ KMT    
Sbjct: 79  IELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138

Query: 158 LVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENC 217
            +M+G  W +   ISF+P+   W              NN+      E+  +  + N+  C
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGW--------------NNIGIIDLIEKRKFNQNSNSTYC 184

Query: 218 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAA 277
              +N+ YAI+ S+++FYIP  +M++ Y RIY  A+    +I  L+RA   ++S   SA 
Sbjct: 185 VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSA- 243

Query: 278 CAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVS 337
              D      ++ ETK  KTL +IMG F  CW PFF+ N + PF      G         
Sbjct: 244 ---DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPG--------- 291

Query: 338 ETTFDVFVWFGWANSSLNPVIYAF-NADFQKVFAQLLGCSHFCSRTP 383
              +  F+W G+ NS LNP +YAF N  F++ F  +L C     R P
Sbjct: 292 -QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP 337


>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
          Length = 413

 Score =  205 bits (521), Expect = 8e-53
 Identities = 119/332 (35%), Positives = 183/332 (55%), Gaps = 34/332 (10%)

Query: 46  LLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAG 105
           +++L+++  + GNVLV  AI +   L+  +TN FI SLA +DL + L V+P+ A   +  
Sbjct: 39  VMSLIVLAIVFGNVLVITAIAKFERLQT-VTNYFITSLACADLVMGLAVVPFGAAHILMK 97

Query: 106 YWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLA 164
            W FG F C+ W + D++C TASI  LCVI+VDRY+AI+ PF+Y+  +T+  A V++ + 
Sbjct: 98  MWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMV 157

Query: 165 WTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRT 224
           W +S L SF+P+Q++W+R         +  N  AN T               CD   N+ 
Sbjct: 158 WIVSGLTSFLPIQMHWYRATHQ-----EAINCYANET--------------CCDFFTNQA 198

Query: 225 YAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSL 284
           YAI+SS++SFY+P+ IM+  Y+R+++ A+ Q+++I   E         +          L
Sbjct: 199 YAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGL 258

Query: 285 RASIK---KETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTF 341
           R S K   KE K LKTL +IMG F  CWLPFFI+N +                 + +  +
Sbjct: 259 RRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN----------LIRKEVY 308

Query: 342 DVFVWFGWANSSLNPVIYAFNADFQKVFAQLL 373
            +  W G+ NS  NP+IY  + DF+  F +LL
Sbjct: 309 ILLNWIGYVNSGFNPLIYCRSPDFRIAFQELL 340


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  201 bits (511), Expect = 1e-51
 Identities = 131/381 (34%), Positives = 197/381 (51%), Gaps = 60/381 (15%)

Query: 24  GNAVGGSAGAPPLGPSQVVTACLLTL----LIIWTLLGNVLVCAAIVRSRHLRANMTNVF 79
           GNA   S    P  P  +  A LL +    LI++ +LGN+LV  ++   RHL + +T+ +
Sbjct: 6   GNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYY 64

Query: 80  IVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDR 138
           IV+LAV+DL +   V+P+ A+ EV GYW FG  FC++W A D++C TASI+ LC+IS+DR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 139 YWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLA 198
           Y  +S P RY   +TQR  L+ +   W LS++IS  P+   W +                
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ---------------- 167

Query: 199 NWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR 258
              P  ED     +N E         Y + S+L SFY+P+AI++V Y R+Y +A+ + R 
Sbjct: 168 ---PAPEDETICQINEE-------PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRG 217

Query: 259 ISS----------------LERAAEHAQSCRSSAACAPDTSLR-ASIKKETKVLKTLSVI 301
           + S                  + A    S  +SA      S+R     +E K  KTL ++
Sbjct: 218 LKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIV 277

Query: 302 MGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAF 361
           +G FV CWLPFF+   ++P  S  P+  P      SET F +  W G+ NS +NP+IY  
Sbjct: 278 VGCFVLCWLPFFL---VMPIGSFFPDFKP------SETVFKIVFWLGYLNSCINPIIYPC 328

Query: 362 NA-DFQKVFAQLLGCSHFCSR 381
           ++ +F+K F  +L     C +
Sbjct: 329 SSQEFKKAFQNVLRIQCLCRK 349


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  201 bits (511), Expect = 1e-51
 Identities = 131/381 (34%), Positives = 197/381 (51%), Gaps = 60/381 (15%)

Query: 24  GNAVGGSAGAPPLGPSQVVTACLLTL----LIIWTLLGNVLVCAAIVRSRHLRANMTNVF 79
           GNA   S    P  P  +  A LL +    LI++ +LGN+LV  ++   RHL + +T+ +
Sbjct: 6   GNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYY 64

Query: 80  IVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDR 138
           IV+LAV+DL +   V+P+ A+ EV GYW FG  FC++W A D++C TASI+ LC+IS+DR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 139 YWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLA 198
           Y  +S P RY   +TQR  L+ +   W LS++IS  P+   W +                
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ---------------- 167

Query: 199 NWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR 258
              P  ED     +N E         Y + S+L SFY+P+AI++V Y R+Y +A+ + R 
Sbjct: 168 ---PAPEDETICQINEE-------PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRG 217

Query: 259 ISS----------------LERAAEHAQSCRSSAACAPDTSLR-ASIKKETKVLKTLSVI 301
           + S                  + A    S  +SA      S+R     +E K  KTL ++
Sbjct: 218 LKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIV 277

Query: 302 MGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAF 361
           +G FV CWLPFF+   ++P  S  P+  P      SET F +  W G+ NS +NP+IY  
Sbjct: 278 VGCFVLCWLPFFL---VMPIGSFFPDFKP------SETVFKIVFWLGYLNSCINPIIYPC 328

Query: 362 NA-DFQKVFAQLLGCSHFCSR 381
           ++ +F+K F  +L     C +
Sbjct: 329 SSQEFKKAFQNVLRIQCLCRK 349


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  201 bits (511), Expect = 1e-51
 Identities = 131/381 (34%), Positives = 197/381 (51%), Gaps = 60/381 (15%)

Query: 24  GNAVGGSAGAPPLGPSQVVTACLLTL----LIIWTLLGNVLVCAAIVRSRHLRANMTNVF 79
           GNA   S    P  P  +  A LL +    LI++ +LGN+LV  ++   RHL + +T+ +
Sbjct: 6   GNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYY 64

Query: 80  IVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDR 138
           IV+LAV+DL +   V+P+ A+ EV GYW FG  FC++W A D++C TASI+ LC+IS+DR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 139 YWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLA 198
           Y  +S P RY   +TQR  L+ +   W LS++IS  P+   W +                
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ---------------- 167

Query: 199 NWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR 258
              P  ED     +N E         Y + S+L SFY+P+AI++V Y R+Y +A+ + R 
Sbjct: 168 ---PAPEDETICQINEE-------PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRG 217

Query: 259 ISS----------------LERAAEHAQSCRSSAACAPDTSLR-ASIKKETKVLKTLSVI 301
           + S                  + A    S  +SA      S+R     +E K  KTL ++
Sbjct: 218 LKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIV 277

Query: 302 MGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAF 361
           +G FV CWLPFF+   ++P  S  P+  P      SET F +  W G+ NS +NP+IY  
Sbjct: 278 VGCFVLCWLPFFL---VMPIGSFFPDFKP------SETVFKIVFWLGYLNSCINPIIYPC 328

Query: 362 NA-DFQKVFAQLLGCSHFCSR 381
           ++ +F+K F  +L     C +
Sbjct: 329 SSQEFKKAFQNVLRIQCLCRK 349


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  201 bits (511), Expect = 1e-51
 Identities = 131/381 (34%), Positives = 197/381 (51%), Gaps = 60/381 (15%)

Query: 24  GNAVGGSAGAPPLGPSQVVTACLLTL----LIIWTLLGNVLVCAAIVRSRHLRANMTNVF 79
           GNA   S    P  P  +  A LL +    LI++ +LGN+LV  ++   RHL + +T+ +
Sbjct: 6   GNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYY 64

Query: 80  IVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDR 138
           IV+LAV+DL +   V+P+ A+ EV GYW FG  FC++W A D++C TASI+ LC+IS+DR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 139 YWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLA 198
           Y  +S P RY   +TQR  L+ +   W LS++IS  P+   W +                
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ---------------- 167

Query: 199 NWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR 258
              P  ED     +N E         Y + S+L SFY+P+AI++V Y R+Y +A+ + R 
Sbjct: 168 ---PAPEDETICQINEE-------PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRG 217

Query: 259 ISS----------------LERAAEHAQSCRSSAACAPDTSLR-ASIKKETKVLKTLSVI 301
           + S                  + A    S  +SA      S+R     +E K  KTL ++
Sbjct: 218 LKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIV 277

Query: 302 MGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAF 361
           +G FV CWLPFF+   ++P  S  P+  P      SET F +  W G+ NS +NP+IY  
Sbjct: 278 VGCFVLCWLPFFL---VMPIGSFFPDFKP------SETVFKIVFWLGYLNSCINPIIYPC 328

Query: 362 NA-DFQKVFAQLLGCSHFCSR 381
           ++ +F+K F  +L     C +
Sbjct: 329 SSQEFKKAFQNVLRIQCLCRK 349


>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
          Length = 397

 Score =  197 bits (501), Expect = 2e-50
 Identities = 116/341 (34%), Positives = 182/341 (53%), Gaps = 58/341 (17%)

Query: 43  TACLLTL------LIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMP 96
           TAC +T+      LI+ T+ GNV+VC A+  +R LR N+TN FIVSLA++DL + LLV+P
Sbjct: 15  TACKITITVVLAVLILITVAGNVVVCLAVGLNRRLR-NLTNCFIVSLAITDLLLGLLVLP 73

Query: 97  WKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQR 155
           + A+ +++  W FG  FC+++ + D+M  TASILNL +IS+DRY A+  P RY   +T  
Sbjct: 74  FSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPV 133

Query: 156 MALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAE 215
              + + L W +SI +SF+ + L W+     S G                     +    
Sbjct: 134 RVAISLVLIWVISITLSFLSIHLGWNSRNETSKG---------------------NHTTS 172

Query: 216 NCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSS 275
            C   +N  Y +   L++FY+P+ IM +TY RI+++A+ Q +RI+ +             
Sbjct: 173 KCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHI------------- 219

Query: 276 AACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPC 335
                 +S +A+  +E K   TL+ +MG F+ CW P+F       F      G  A    
Sbjct: 220 ------SSWKAATIREHKATVTLAAVMGAFIICWFPYF-----TAFVYRGLRGDDA---- 264

Query: 336 VSETTFDVFVWFGWANSSLNPVIY-AFNADFQKVFAQLLGC 375
           ++E    + +W G+ANS+LNP++Y A N DF+  + QL  C
Sbjct: 265 INEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCC 305


>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
          Length = 359

 Score =  197 bits (501), Expect = 2e-50
 Identities = 116/341 (34%), Positives = 182/341 (53%), Gaps = 58/341 (17%)

Query: 43  TACLLTL------LIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMP 96
           TAC +T+      LI+ T+ GNV+VC A+  +R LR N+TN FIVSLA++DL + LLV+P
Sbjct: 15  TACKITITVVLAVLILITVAGNVVVCLAVGLNRRLR-NLTNCFIVSLAITDLLLGLLVLP 73

Query: 97  WKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQR 155
           + A+ +++  W FG  FC+++ + D+M  TASILNL +IS+DRY A+  P RY   +T  
Sbjct: 74  FSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPV 133

Query: 156 MALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAE 215
              + + L W +SI +SF+ + L W+     S G                     +    
Sbjct: 134 RVAISLVLIWVISITLSFLSIHLGWNSRNETSKG---------------------NHTTS 172

Query: 216 NCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSS 275
            C   +N  Y +   L++FY+P+ IM +TY RI+++A+ Q +RI+ +             
Sbjct: 173 KCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHI------------- 219

Query: 276 AACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPC 335
                 +S +A+  +E K   TL+ +MG F+ CW P+F       F      G  A    
Sbjct: 220 ------SSWKAATIREHKATVTLAAVMGAFIICWFPYF-----TAFVYRGLRGDDA---- 264

Query: 336 VSETTFDVFVWFGWANSSLNPVIY-AFNADFQKVFAQLLGC 375
           ++E    + +W G+ANS+LNP++Y A N DF+  + QL  C
Sbjct: 265 INEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCC 305


>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score =  197 bits (501), Expect = 2e-50
 Identities = 129/379 (34%), Positives = 197/379 (51%), Gaps = 64/379 (16%)

Query: 24  GNAVGGSA--GAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIV 81
           G  V G+A  G   +    V     L   I+  + GN+LV  ++  +RHL+  +TN FIV
Sbjct: 78  GGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQT-VTNYFIV 136

Query: 82  SLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYW 140
           +LAV+DL ++  V+P+ A  EV G+W FG AFCDVW A D++C TASIL+LC ISVDRY 
Sbjct: 137 NLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYV 196

Query: 141 AISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANW 200
            +    +Y   MT+R A  ++ L W +++++S  P+ L W                    
Sbjct: 197 GVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPL-LGWKEP----------------- 238

Query: 201 TPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRI- 259
            P +E F         C  +    YA+ SS+ SFY+P+A+++V Y R+Y +A+   R + 
Sbjct: 239 VPPDERF---------CGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLE 289

Query: 260 SSLERAAEHAQS------CRSSAA---------CAPDTSLRASI-------KKETKVLKT 297
           + ++R    A        CR +A           A   + R+S+        +E K  KT
Sbjct: 290 AGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKT 349

Query: 298 LSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPV 357
           L++++GVFV CW PFF    ++P  S  P+  P      SE  F V  W G+ NS +NP+
Sbjct: 350 LAIVVGVFVLCWFPFFF---VLPLGSLFPQLKP------SEGVFKVIFWLGYFNSCVNPL 400

Query: 358 IYAFNA-DFQKVFAQLLGC 375
           IY  ++ +F++ F +LL C
Sbjct: 401 IYPCSSREFKRAFLRLLRC 419


>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
          Length = 408

 Score =  189 bits (481), Expect = 4e-48
 Identities = 119/362 (32%), Positives = 178/362 (49%), Gaps = 46/362 (12%)

Query: 30  SAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLF 89
           ++G P +     +   LL L ++ T+ GN+LV  AI  +  L+  MTNVF+ SLA +DL 
Sbjct: 27  TSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQT-MTNVFVTSLAAADLV 85

Query: 90  VALLVMPWKAVAEVAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRY 148
           + LLV+P  A   + G+WP GA  C++W + D++C TASI  LC ++VDRY A++ P RY
Sbjct: 86  MGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRY 145

Query: 149 KRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFW 208
              +T+R A   V L W +S  +SF P+   W R  A                  + +  
Sbjct: 146 GALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGA------------------DAEAQ 187

Query: 209 EPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRI-SSLER--- 264
               N   C  + N  Y + SS +SFY+P+ +M+  Y R++ +A  Q+R +   L R   
Sbjct: 188 RCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPP 247

Query: 265 -----AAEHAQSCRSSAACAPDTSLRASIK--------KETKVLKTLSVIMGVFVCCWLP 311
                A   + +      CAP   + A  +        +E + L TL +IMG F  CWLP
Sbjct: 248 EESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLP 307

Query: 312 FFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQ 371
           FF+ N +             G   V    F    W G+ANS+ NP+IY  + DF+  F +
Sbjct: 308 FFLANVLRAL---------GGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRR 358

Query: 372 LL 373
           LL
Sbjct: 359 LL 360


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score =  187 bits (475), Expect = 2e-47
 Identities = 123/374 (32%), Positives = 194/374 (51%), Gaps = 60/374 (16%)

Query: 25  NAVGGSAGAPPLGPSQVVTACL-LTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSL 83
           N    ++  P L  ++ ++  L L   I++ ++GN+LV  ++  +RHLR   TN FIV+L
Sbjct: 29  NQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTP-TNYFIVNL 87

Query: 84  AVSDLFVALLVMPWKAVAEVAGYWPFGA-FCDVWVAFDIMCSTASILNLCVISVDRYWAI 142
           A++DL ++  V+P+ A  EV GYW  G  FCD+W A D++C TASIL+LC IS+DRY  +
Sbjct: 88  AMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGV 147

Query: 143 SRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTP 202
               +Y   +T+R A++ +   W LS +IS  P+ L W             PN+      
Sbjct: 148 RYSLQYPTLVTRRKAILALLSVWVLSTVISIGPL-LGWKE---------PAPNDDKECGV 197

Query: 203 WEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISS- 261
            EE F                 YA+ SSL SFYIP+A+++V Y R+Y +A+   + + + 
Sbjct: 198 TEEPF-----------------YALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG 240

Query: 262 ----LERAAE----------HAQSCRSSAACA--PDTSLRASI---KKETKVLKTLSVIM 302
               +  + E          H  +  S+ A    P +S+   +    +E K  KTL +++
Sbjct: 241 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV 300

Query: 303 GVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFN 362
           G+F+ CWLPFFI    +P  S      P       +  F V  W G+ NS LNP+IY  +
Sbjct: 301 GMFILCWLPFFI---ALPLGSLFSTLKP------PDAVFKVVFWLGYFNSCLNPIIYPCS 351

Query: 363 A-DFQKVFAQLLGC 375
           + +F++ F ++LGC
Sbjct: 352 SKEFKRAFVRILGC 365


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  179 bits (454), Expect = 5e-45
 Identities = 122/374 (32%), Positives = 173/374 (46%), Gaps = 74/374 (19%)

Query: 38  PSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPW 97
           P +V+   LL L+ + T L N  V A + R+R L     N  I SLAV+DL V++LVMP 
Sbjct: 47  PWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTP-ANYLIASLAVTDLLVSILVMPI 105

Query: 98  KAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRM 156
             +  V G W  G   CD W++ DI C TASIL+LCVI++DRYWAI+    Y  K T + 
Sbjct: 106 STMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKR 165

Query: 157 ALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAEN 216
           A VM+ L W  SI IS  P    W + +A                  EE+  E  VN ++
Sbjct: 166 AAVMIALVWVFSISISLPP--FFWRQAKA------------------EEEVSECVVNTDH 205

Query: 217 CDSSLNRTYAISSSLISFYIPVAIMIVTYTRIY-----------------RIAQVQI--- 256
                   Y + S++ +FY P  ++I  Y RIY                 R+ + Q+   
Sbjct: 206 I------LYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITD 259

Query: 257 -----RRISSLERAAEHAQSCRSSAACAPDTSLRAS----------IKKETKVLKTLSVI 301
                  ++S+        S   S        +R S            +E K  KTL +I
Sbjct: 260 SPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGII 319

Query: 302 MGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPC-VSETTFDVFVWFGWANSSLNPVIYA 360
           +G F+ CWLPFFI++ ++P C            C      FD F W G+ NS +NP+IY 
Sbjct: 320 LGAFIVCWLPFFIISLVMPICKD---------ACWFHLAIFDFFTWLGYLNSLINPIIYT 370

Query: 361 F-NADFQKVFAQLL 373
             N DF++ F +L+
Sbjct: 371 MSNEDFKQAFHKLI 384


>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
           sapiens]
          Length = 440

 Score =  178 bits (452), Expect = 8e-45
 Identities = 122/356 (34%), Positives = 173/356 (48%), Gaps = 46/356 (12%)

Query: 31  AGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFV 90
           AG P         A  L ++I  T   N L+ A I     LR N +N F+VSL  SDL V
Sbjct: 17  AGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALR-NTSNFFLVSLFTSDLMV 75

Query: 91  ALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYK 149
            L+VMP   +  + G W      C +W AFD+MC +ASILNLC+IS+DRY  I  P RYK
Sbjct: 76  GLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYK 135

Query: 150 RKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWE 209
            +MT   AL +V  AW+L+ L SF+P+ L WH                      E     
Sbjct: 136 LRMTPLRALALVLGAWSLAALASFLPLLLGWH----------------------ELGHAR 173

Query: 210 PDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSL-----ER 264
           P V  + C    +  + + +S ++F++P   +  TY RI   A+ Q  +++SL      +
Sbjct: 174 PPVPGQ-CRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQ 232

Query: 265 AAEHAQSCRSSAACAPDT-SLRASIKKETKVLK---TLSVIMGVFVCCWLPFFILNCMVP 320
           A+E  Q  R+         S R + K   K LK   TL +++G+F   WLPFF+ N +  
Sbjct: 233 ASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQA 292

Query: 321 FCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIY-AFNADFQKVFAQLLGC 375
            C            C+S   FDV  W G+ NS++NP+IY  F  DF++   + L C
Sbjct: 293 VCD-----------CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337


>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
          Length = 432

 Score =  177 bits (449), Expect = 2e-44
 Identities = 116/359 (32%), Positives = 179/359 (49%), Gaps = 57/359 (15%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           +VV   +LTL+ + T+ GN LV  ++   + LR   +N  IVSLA++DL VA+ VMP+ +
Sbjct: 81  KVVIGSILTLITLLTIAGNCLVVISVCFVKKLR-QPSNYLIVSLALADLSVAVAVMPFVS 139

Query: 100 VAE-VAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMA 157
           V + + G W FG F C+V++A D+MC TASI+ LCVIS+DRY  I+RP  Y  +   +  
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199

Query: 158 LVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAEN- 216
             M+   W LS  I+  P+           +G                  W  +VN +  
Sbjct: 200 AKMILSVWLLSASITLPPL-----------FG------------------WAQNVNDDKV 230

Query: 217 CDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR----------------IS 260
           C  S +  Y I S+ ++FYIP+++M+  Y +IY+ A+    +                ++
Sbjct: 231 CLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALN 290

Query: 261 SLERAAEHAQSCRSSAACAPDTSLRASI-KKETKVLKTLSVIMGVFVCCWLPFFILNCMV 319
            + +  +  + C + +          SI K+E K   TL +I+G F  CWLPFF+L+   
Sbjct: 291 GIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTAR 350

Query: 320 PFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA-FNADFQKVFAQLLGCSH 377
           PF  G          C+       F+W G+ANS +NP IYA FN D +  +  LL C +
Sbjct: 351 PFICG------TSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403


>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
          Length = 479

 Score =  177 bits (449), Expect = 2e-44
 Identities = 116/359 (32%), Positives = 179/359 (49%), Gaps = 57/359 (15%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           +VV   +LTL+ + T+ GN LV  ++   + LR   +N  IVSLA++DL VA+ VMP+ +
Sbjct: 81  KVVIGSILTLITLLTIAGNCLVVISVCFVKKLR-QPSNYLIVSLALADLSVAVAVMPFVS 139

Query: 100 VAE-VAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMA 157
           V + + G W FG F C+V++A D+MC TASI+ LCVIS+DRY  I+RP  Y  +   +  
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199

Query: 158 LVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAEN- 216
             M+   W LS  I+  P+           +G                  W  +VN +  
Sbjct: 200 AKMILSVWLLSASITLPPL-----------FG------------------WAQNVNDDKV 230

Query: 217 CDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR----------------IS 260
           C  S +  Y I S+ ++FYIP+++M+  Y +IY+ A+    +                ++
Sbjct: 231 CLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALN 290

Query: 261 SLERAAEHAQSCRSSAACAPDTSLRASI-KKETKVLKTLSVIMGVFVCCWLPFFILNCMV 319
            + +  +  + C + +          SI K+E K   TL +I+G F  CWLPFF+L+   
Sbjct: 291 GIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTAR 350

Query: 320 PFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA-FNADFQKVFAQLLGCSH 377
           PF  G          C+       F+W G+ANS +NP IYA FN D +  +  LL C +
Sbjct: 351 PFICG------TSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403


>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
          Length = 445

 Score =  177 bits (449), Expect = 2e-44
 Identities = 116/359 (32%), Positives = 179/359 (49%), Gaps = 57/359 (15%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           +VV   +LTL+ + T+ GN LV  ++   + LR   +N  IVSLA++DL VA+ VMP+ +
Sbjct: 81  KVVIGSILTLITLLTIAGNCLVVISVCFVKKLR-QPSNYLIVSLALADLSVAVAVMPFVS 139

Query: 100 VAE-VAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMA 157
           V + + G W FG F C+V++A D+MC TASI+ LCVIS+DRY  I+RP  Y  +   +  
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199

Query: 158 LVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAEN- 216
             M+   W LS  I+  P+           +G                  W  +VN +  
Sbjct: 200 AKMILSVWLLSASITLPPL-----------FG------------------WAQNVNDDKV 230

Query: 217 CDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR----------------IS 260
           C  S +  Y I S+ ++FYIP+++M+  Y +IY+ A+    +                ++
Sbjct: 231 CLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALN 290

Query: 261 SLERAAEHAQSCRSSAACAPDTSLRASI-KKETKVLKTLSVIMGVFVCCWLPFFILNCMV 319
            + +  +  + C + +          SI K+E K   TL +I+G F  CWLPFF+L+   
Sbjct: 291 GIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTAR 350

Query: 320 PFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA-FNADFQKVFAQLLGCSH 377
           PF  G          C+       F+W G+ANS +NP IYA FN D +  +  LL C +
Sbjct: 351 PFICG------TSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  176 bits (447), Expect = 3e-44
 Identities = 117/369 (31%), Positives = 178/369 (48%), Gaps = 70/369 (18%)

Query: 40  QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
           ++  A +L+++ + T+L N  V   I+ +R L     N  I SLA +DL V++LVMP   
Sbjct: 38  KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTP-ANYLIGSLATTDLLVSILVMPISI 96

Query: 100 VAEVAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMAL 158
              +   W FG   CD+W++ DI C TASIL+LCVI++DRYWAI+    Y ++ T   A 
Sbjct: 97  AYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAA 156

Query: 159 VMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCD 218
            M+ + W +SI IS  P  L W + +A                  +E+  +  VN     
Sbjct: 157 TMIAIVWAISICISIPP--LFWRQAKA------------------QEEMSDCLVNTSQI- 195

Query: 219 SSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLE----RAAEHAQSCRS 274
                +Y I S+  +FYIP  ++I+ Y RIYR A+ +I    SL       A        
Sbjct: 196 -----SYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAG 250

Query: 275 SAACAPDTSL-----------------------------RASIKKETKVLKTLSVIMGVF 305
           S+ C+ ++SL                             R S  +E K  K L +I+G F
Sbjct: 251 SSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAF 310

Query: 306 VCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIY-AFNAD 364
           + CWLPFF+++ ++P C       PA         FD F W G+ NS +NP+IY  FN +
Sbjct: 311 IICWLPFFVVSLVLPICRDSCWIHPA--------LFDFFTWLGYLNSLINPIIYTVFNEE 362

Query: 365 FQKVFAQLL 373
           F++ F +++
Sbjct: 363 FRQAFQKIV 371


>gi|21264324 trace amine associated receptor 1 [Homo sapiens]
          Length = 339

 Score =  169 bits (428), Expect = 5e-42
 Identities = 108/317 (34%), Positives = 160/317 (50%), Gaps = 40/317 (12%)

Query: 46  LLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAG 105
           L+ L+I+ TL+GN++V  +I   + L    TN  I S+A  D  +  LVMP+  V     
Sbjct: 29  LMVLIILTTLVGNLIVIVSISHFKQLHTP-TNWLIHSMATVDFLLGCLVMPYSMVRSAEH 87

Query: 106 YWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLA 164
            W FG  FC +  + DIM S+ASI +L  IS+DRY+A+  P RYK KM   +  VM+ ++
Sbjct: 88  CWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFIS 147

Query: 165 WTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRT 224
           W++  + +F  + L                    N+   EE +++       C    ++ 
Sbjct: 148 WSVPAVFAFGMIFLE------------------LNFKGAEEIYYKHVHCRGGCSVFFSKI 189

Query: 225 YAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSL 284
             + + + SFYIP +IM+  Y RIY IA+ Q R IS   +  +     ++          
Sbjct: 190 SGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG--------- 240

Query: 285 RASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVF 344
             S  KE K +KTL ++MGVF+ CW PFFI   M PF   H   PP        T  DV 
Sbjct: 241 -ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL--HYIIPP--------TLNDVL 289

Query: 345 VWFGWANSSLNPVIYAF 361
           +WFG+ NS+ NP++YAF
Sbjct: 290 IWFGYLNSTFNPMVYAF 306


>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
          Length = 357

 Score =  166 bits (421), Expect = 3e-41
 Identities = 107/364 (29%), Positives = 175/364 (48%), Gaps = 58/364 (15%)

Query: 33  APPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVAL 92
           +P L    V+   LL  L+  T   N+LV A I+R R       N+ + S+AVSD+ VA 
Sbjct: 33  SPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNL-VASMAVSDVLVAA 91

Query: 93  LVMPWKAVAEVAGY-WPFGA-FCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKR 150
           LVMP   V E++G  W  G   C +W+A D++C TASI N+  I++DRYW+I+R   Y  
Sbjct: 92  LVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTL 151

Query: 151 KMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEP 210
           +  + ++ VM+ L W LS +IS  P+   W    +                         
Sbjct: 152 RTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEG----------------------- 188

Query: 211 DVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQI-----RRISSLERA 265
              +E C  S   +YA+ S++ +FY+P+ +++  Y +IY+ A+ ++       +S +  A
Sbjct: 189 ---SEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEA 245

Query: 266 AEHAQSCRSSAACAPDTSLRASI-----------KKETKVLKTLSVIMGVFVCCWLPFFI 314
            E   S +        T   A++           +KE +    + +++GVFV CW+PFF+
Sbjct: 246 VEVKDSAKQPQMVF--TVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFL 303

Query: 315 LNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIY-AFNADFQKVFAQLL 373
              + P CS          P + ++   +F+W G++NS  NP+IY AFN ++   F    
Sbjct: 304 TELISPLCS-------CDIPAIWKS---IFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFF 353

Query: 374 GCSH 377
              H
Sbjct: 354 SRQH 357


>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
          Length = 367

 Score =  161 bits (408), Expect = 1e-39
 Identities = 125/396 (31%), Positives = 178/396 (44%), Gaps = 92/396 (23%)

Query: 25  NAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLA 84
           N+ G S   P       ++ C L L I++   GN LVC A+++ R L+   TN  +VSLA
Sbjct: 19  NSTGASQARPHA--YYALSYCALILAIVF---GNGLVCMAVLKERALQTT-TNYLVVSLA 72

Query: 85  VSDLFVALLVMPWKAVAEVAG-YWPFGAFC-DVWVAFDIMCSTASILNLCVISVDRYWAI 142
           V+DL VA LVMPW    EV G  W F   C DV+V  D+M  TASILNLC IS+DRY A+
Sbjct: 73  VADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAV 132

Query: 143 SRPFRYKRKMTQ---RMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLAN 199
             P  Y+    Q   R   +M+   W L+  +S  P+   ++                  
Sbjct: 133 VMPVHYQHGTGQSSCRRVALMITAVWVLAFAVS-CPLLFGFNTT---------------- 175

Query: 200 WTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRI 259
                    +P V    C  S N  + I SS++SFY+P  + ++ Y RIY + + Q RR 
Sbjct: 176 --------GDPTV----CSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVVLK-QRRRK 221

Query: 260 SSLERAAEHAQS-------------------------CRSSAACAPDTSLR-ASIKKETK 293
             L R      S                         C+ +A   P    R   +K+E K
Sbjct: 222 RILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEK 281

Query: 294 VLKTL------------SVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPC-VSETT 340
              +L            ++++G F+ CWLPFF+ + +   C            C VS   
Sbjct: 282 TRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ----------TCHVSPEL 331

Query: 341 FDVFVWFGWANSSLNPVIY-AFNADFQKVFAQLLGC 375
           +    W G+ NS+LNPVIY  FN +F+K F ++L C
Sbjct: 332 YSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367


>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
           sapiens]
          Length = 365

 Score =  158 bits (400), Expect = 9e-39
 Identities = 115/371 (30%), Positives = 171/371 (46%), Gaps = 78/371 (21%)

Query: 47  LTLLIIWTL--LGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVA 104
           +TL++I TL  L N+ V  AI  ++ L     N  I SLAV+DL VA+LVMP   +  V 
Sbjct: 27  MTLVVITTLTTLLNLAVIMAIGTTKKLH-QPANYLICSLAVTDLLVAVLVMPLSIIYIVM 85

Query: 105 GYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGL 163
             W  G F C+VW++ D+ C T SIL+LCVI++DRYWAI+    Y RK T + A +M+  
Sbjct: 86  DRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILT 145

Query: 164 AWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNR 223
            WT+SI IS  P+    HR  +       + ++                         + 
Sbjct: 146 VWTISIFISMPPLFWRSHRRLSPPPSQCTIQHD-------------------------HV 180

Query: 224 TYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAA------ 277
            Y I S+L +FYIP+ ++++ Y RIY  A+   ++  S    +  +   ++S A      
Sbjct: 181 IYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQ 240

Query: 278 --CAPDTS----------LRASIK--------------------KETKVLKTLSVIMGVF 305
             C  D S            ASI+                    +E K  + L +I+G F
Sbjct: 241 TFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300

Query: 306 VCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIY-AFNAD 364
           +  WLPFFI   +V                VS    D   W G+ NS +NP++Y +FN D
Sbjct: 301 ILSWLPFFIKELIVGL----------SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNED 350

Query: 365 FQKVFAQLLGC 375
           F+  F +L+ C
Sbjct: 351 FKLAFKKLIRC 361


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.136    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,545,478
Number of Sequences: 37866
Number of extensions: 788264
Number of successful extensions: 4033
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 423
Number of HSP's successfully gapped in prelim test: 224
Number of HSP's that attempted gapping in prelim test: 2613
Number of HSP's gapped (non-prelim): 958
length of query: 477
length of database: 18,247,518
effective HSP length: 106
effective length of query: 371
effective length of database: 14,233,722
effective search space: 5280710862
effective search space used: 5280710862
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.