Search of human proteins with 4503243

Search of human proteins with 4503243

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide
1 isoform 1 [Homo sapiens]
         (509 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ...  1029   0.0  
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid...   826   0.0  
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   123   5e-28
gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide...   116   6e-26
gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide...   111   2e-24
gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide...   108   1e-23
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   106   4e-23
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   102   6e-22
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   102   8e-22
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   101   1e-21
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   101   1e-21
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                   99   1e-20
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...    99   1e-20
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...    99   1e-20
gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide ...    98   2e-20
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...    98   2e-20
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                         94   3e-19
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...    93   5e-19
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...    93   5e-19
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...    93   5e-19
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...    93   7e-19
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...    91   2e-18
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...    89   9e-18
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...    89   9e-18
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...    89   1e-17
gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide...    85   2e-16
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...    84   3e-16
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...    84   4e-16
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...    83   5e-16
gi|62952502 cytochrome P450, family 26, subfamily C, polypeptide...    83   5e-16

>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 1 [Homo sapiens]
          Length = 509

 Score = 1029 bits (2661), Expect = 0.0
 Identities = 509/509 (100%), Positives = 509/509 (100%)

Query: 1   MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL 60
           MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL
Sbjct: 1   MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL 60

Query: 61  PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA 120
           PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA
Sbjct: 61  PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA 120

Query: 121 ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI 180
           ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
Sbjct: 121 ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI 180

Query: 181 IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF 240
           IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF
Sbjct: 181 IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF 240

Query: 241 SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR 300
           SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR
Sbjct: 241 SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR 300

Query: 301 PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY 360
           PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY
Sbjct: 301 PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY 360

Query: 361 DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS 420
           DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS
Sbjct: 361 DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS 420

Query: 421 WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL 480
           WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL
Sbjct: 421 WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL 480

Query: 481 IDGYFPTVNYTTMIHTPENPVIRYKRRSK 509
           IDGYFPTVNYTTMIHTPENPVIRYKRRSK
Sbjct: 481 IDGYFPTVNYTTMIHTPENPVIRYKRRSK 509


>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 2 [Homo sapiens]
          Length = 404

 Score =  826 bits (2134), Expect = 0.0
 Identities = 404/404 (100%), Positives = 404/404 (100%)

Query: 106 MVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKML 165
           MVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKML
Sbjct: 1   MVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKML 60

Query: 166 KSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQL 225
           KSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQL
Sbjct: 61  KSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQL 120

Query: 226 NEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKID 285
           NEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKID
Sbjct: 121 NEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKID 180

Query: 286 DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYL 345
           DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYL
Sbjct: 181 DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYL 240

Query: 346 EQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGH 405
           EQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGH
Sbjct: 241 EQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGH 300

Query: 406 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQI 465
           QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQI
Sbjct: 301 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQI 360

Query: 466 KTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK 509
           KTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
Sbjct: 361 KTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK 404


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  123 bits (308), Expect = 5e-28
 Identities = 106/425 (24%), Positives = 181/425 (42%), Gaps = 33/425 (7%)

Query: 76  FLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVG--KTFTYLLGSDAAALLFNSKNEDLNA 133
           FLGH        +E LE   EKY   F F  +G  + F  +   D A  L +  +     
Sbjct: 54  FLGHQKFIQDDNMEKLEEIIEKYPRAFPF-WIGPFQAFFCIYDPDYAKTLLSRTDPK--- 109

Query: 134 EDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWG 193
                + + P+ GKG+A  +  P + + +++L  G +    K ++ ++    K   + W 
Sbjct: 110 SQYLQKFSPPLLGKGLAA-LDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWE 168

Query: 194 -----ESGEKNVFEALSELIILTASHCLHGKEIRSQLN---EKVAQLYADLDGGFSHAAW 245
                +     V+E ++ + +     C   KE   Q N   +  A+   +L     H  +
Sbjct: 169 KICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLY 228

Query: 246 LLPGWLPL-----PSFRRRDRAHREIKDIFYKAIQKRRQS-----------QEKIDDILQ 289
            L     +     P   R  +  R +       IQ+R++S           + K  D L 
Sbjct: 229 SLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLD 288

Query: 290 TLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKT 349
            +L A  + G   +D +V   +   LLAG  T + + +W+ + LA +   Q++C  E + 
Sbjct: 289 IVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRG 348

Query: 350 VCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGHQVC 408
           + G+    +T+DQL +++    CIKET RL P +  + R    P T   G T+P G  V 
Sbjct: 349 ILGDG-SSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVV 407

Query: 409 VSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTI 468
           +S          W     F+P R+ Q+N      +AY+PF AG   CIG+ FA +++K  
Sbjct: 408 LSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVT 467

Query: 469 WSTML 473
            + +L
Sbjct: 468 IALIL 472


>gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide 1
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  116 bits (290), Expect = 6e-26
 Identities = 114/492 (23%), Positives = 208/492 (42%), Gaps = 24/492 (4%)

Query: 33  LSMLLIACAFTLSLVYLIRLAAGHLVQL--------PAGVKSPPYIFSPIPFLGHAIAFG 84
           L  LL +   T  L  L+ LAA  L  L           +  PP      PF G  +   
Sbjct: 3   LPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMG-FPFFGETLQMV 61

Query: 85  KSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPV 144
               +FL+    KYG ++   + G+    ++G+D    +   ++  ++     S  T  +
Sbjct: 62  LQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRT--I 119

Query: 145 FGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKN--VFE 202
            G G   ++ +    ++KK++    +    + +V +I +E     E W   GE+   V+ 
Sbjct: 120 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYP 179

Query: 203 ALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRR---- 258
            +  L+   A   L G E +   +    Q   +     +   + LP  +P     R    
Sbjct: 180 EVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKA 239

Query: 259 RDRAHREIKDIFYKAIQKRRQSQ--EKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLL 316
           R+  H  I+      I   R S+  +   D LQ L++ +++ G  L    +      LL 
Sbjct: 240 RNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLF 299

Query: 317 AGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKT---VCGENLP-PLTYDQLKDLNLLDRC 372
            G  T+++ +  +  +L     + +K   E K+   +C  N    L  + L+ L  +   
Sbjct: 300 GGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCV 359

Query: 373 IKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRY 432
           IKETLRL PP+    R+A     + GY IP G  V  S      + + +  + +FNPDR+
Sbjct: 360 IKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRF 419

Query: 433 LQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTT 492
           +  +P    +F+++PFG G   C+G+ FA + +K     + R  ++ L++G  PT+  + 
Sbjct: 420 MLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGP-PTMKTSP 478

Query: 493 MIHTPENPVIRY 504
            ++  +N   R+
Sbjct: 479 TVYPVDNLPARF 490


>gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 469

 Score =  111 bits (277), Expect = 2e-24
 Identities = 113/482 (23%), Positives = 210/482 (43%), Gaps = 39/482 (8%)

Query: 45  SLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSF 104
           +++ ++   A  L+     ++ PP I   IP++G    FGK+P+EF+E A  KYGP+F+ 
Sbjct: 7   TVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTV 66

Query: 105 TMVGKTFTYLLGSDAAALLFNSKNED--LNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQK 162
             +G   T++   +   +   SK  D  L  +++  R  +          +P  VFL   
Sbjct: 67  FAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTAS----------IPKNVFLALH 116

Query: 163 K----MLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHG 218
           +    MLK  +   +  Q    + +E  E  E+ G  G  ++   +  L+     + L  
Sbjct: 117 EKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFN 176

Query: 219 KEIRSQLNEKVA---QLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQ 275
           K + S   +K+    Q +   D  F + +      LP    R   ++ +   ++F K I 
Sbjct: 177 KSLFSTNKKKIKEFHQYFQVYDEDFEYGS-----QLPECLLRNWSKSKKWFLELFEKNIP 231

Query: 276 KRRQSQEKIDDILQTLLDATYKDGRPLTDDEVA---GMLIGLLLAGQHTSSTTSAWMGFF 332
             +  +   D+ + TLL AT       T  E +   G+L  LL A    +   + W   +
Sbjct: 232 DIKACKSAKDNSM-TLLQATLDIVETETSKENSPNYGLL--LLWASLSNAVPVAFWTLAY 288

Query: 333 LARDKTLQKKCYLEQKTV---CGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRM 389
           +     + K       +V    G++   ++ D L++L L+  C+ ET+RL+ P +I  ++
Sbjct: 289 VLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKV 348

Query: 390 ARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKF-AYVPF 448
            + P  +  Y IP G  + +SP    R    + E   F P+R+ + N         ++ F
Sbjct: 349 VK-PVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAF 407

Query: 449 GAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPE---NPVIRYK 505
           G+G+ +C    FA ++++     +L  Y+  L+D   P  +Y  ++  P+      I YK
Sbjct: 408 GSGKFQCPARWFALLEVQMCIILILYKYDCSLLDP-LPKQSYLHLVGVPQPEGQCRIEYK 466

Query: 506 RR 507
           +R
Sbjct: 467 QR 468


>gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide 1
           isoform 2 [Homo sapiens]
          Length = 428

 Score =  108 bits (270), Expect = 1e-23
 Identities = 96/420 (22%), Positives = 184/420 (43%), Gaps = 15/420 (3%)

Query: 97  KYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNP 156
           KYG ++   + G+    ++G+D    +   ++  ++     S  T  + G G   ++ + 
Sbjct: 5   KYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRT--ILGSGCLSNLHDS 62

Query: 157 VFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKN--VFEALSELIILTASH 214
              ++KK++    +    + +V +I +E     E W   GE+   V+  +  L+   A  
Sbjct: 63  SHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMR 122

Query: 215 CLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRR----RDRAHREIKDIF 270
            L G E +   +    Q   +     +   + LP  +P     R    R+  H  I+   
Sbjct: 123 ILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNI 182

Query: 271 YKAIQKRRQSQ--EKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAW 328
              I   R S+  +   D LQ L++ +++ G  L    +      LL  G  T+++ +  
Sbjct: 183 RAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATS 242

Query: 329 MGFFLARDKTLQKKCYLEQKT---VCGENLP-PLTYDQLKDLNLLDRCIKETLRLRPPIM 384
           +  +L     + +K   E K+   +C  N    L  + L+ L  +   IKETLRL PP+ 
Sbjct: 243 LITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVP 302

Query: 385 IMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFA 444
              R+A     + GY IP G  V  S      + + +  + +FNPDR++  +P    +F+
Sbjct: 303 GGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFS 362

Query: 445 YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRY 504
           ++PFG G   C+G+ FA + +K     + R  ++ L++G  PT+  +  ++  +N   R+
Sbjct: 363 FIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGP-PTMKTSPTVYPVDNLPARF 421


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  106 bits (265), Expect = 4e-23
 Identities = 94/370 (25%), Positives = 161/370 (43%), Gaps = 32/370 (8%)

Query: 134 EDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESW- 192
           +D++     P  G G+     +  +   +++L    +    K ++ I  +        W 
Sbjct: 129 DDLFYGFLKPWLGDGLLLSKGDK-WSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWR 187

Query: 193 ----GESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYA---DLDGGFSHAAW 245
               G +   ++FE +S + + +   C+      S   EK++   +   +L        +
Sbjct: 188 HLAEGSAVSLDMFEHISLMTLDSLQKCVFS--YNSNCQEKMSDYISAIIELSALSVRRQY 245

Query: 246 LLPGWLPLPSFRRRD-RAHREIKDIFY----KAIQKRRQS-------------QEKIDDI 287
            L  +L    +R  D R  R+  D+ +    + IQ+RR++             Q K  D 
Sbjct: 246 RLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDF 305

Query: 288 LQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE- 346
           +  LL A  +DG+ L+D+++       +  G  T+S+  +WM F LA+    Q+KC  E 
Sbjct: 306 IDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEI 365

Query: 347 QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGH 405
           Q+ + G  L  L +D L  L     CIKE+LR  PP+ ++ R       +  G  IP G 
Sbjct: 366 QEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGI 425

Query: 406 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQI 465
              VS          W +   +NP R+  DNP      AYVPF AG   CIG++FA  ++
Sbjct: 426 ICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAEL 485

Query: 466 KTIWS-TMLR 474
           + + + T+LR
Sbjct: 486 RVVVALTLLR 495


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  102 bits (255), Expect = 6e-22
 Identities = 111/464 (23%), Positives = 194/464 (41%), Gaps = 40/464 (8%)

Query: 41  AFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGP 100
           A +L L+YL    +  L +   G+  P    +P+PFLG+ +++ K    F    ++KYG 
Sbjct: 16  AVSLVLLYLYGTHSHGLFK-KLGIPGP----TPLPFLGNILSYHKGFCMFDMECHKKYGK 70

Query: 101 VFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTT-----PV-FGKGVAYDVP 154
           V+ F        Y       A+      + +  ++ YS  T      PV F K       
Sbjct: 71  VWGF--------YDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAE 122

Query: 155 NPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGE-------KNVFEALSEL 207
           +  +   + +L         K+ V II +       +     E       K+VF A S  
Sbjct: 123 DEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMD 182

Query: 208 IILTASHCLHGKEIRSQLNEKVAQ----LYADLDGGFSHAAWLLPGWLPLPSFRRRDRAH 263
           +I + S  ++   + +  +  V      L  D    F  +  + P  +P+          
Sbjct: 183 VITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFP 242

Query: 264 REIKDIFYKAIQKRRQS-----QEKIDDILQTLLDATY----KDGRPLTDDEVAGMLIGL 314
           RE+ +   K++++ ++S     Q+   D LQ ++D+      +  + L+D E+    I  
Sbjct: 243 REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIF 302

Query: 315 LLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIK 374
           + AG  T+S+  +++ + LA    +Q+K   E   V     PP TYD +  +  LD  + 
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVN 361

Query: 375 ETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQ 434
           ETLRL P  M + R+ +    + G  IP G  V +      R    W E   F P+R+ +
Sbjct: 362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 435 DNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF 478
            N  + + + Y PFG+G   CIG  FA + +K     +L+ + F
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 465


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  102 bits (254), Expect = 8e-22
 Identities = 62/195 (31%), Positives = 94/195 (48%)

Query: 280 SQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTL 339
           S+ K    L  LL  T  +G  L+ +++   +   +  G  T++    W  + L  +  +
Sbjct: 292 SKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEV 351

Query: 340 QKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGY 399
           QKK   E   V G++  P T + LK L  L+  IKETLRL P + +  R       VAGY
Sbjct: 352 QKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGY 411

Query: 400 TIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGEN 459
            +  G +  + P    R    +    +F P+R+  +N      +AYVPF AG   CIG+ 
Sbjct: 412 RVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQK 471

Query: 460 FAYVQIKTIWSTMLR 474
           FA ++ KTI S +LR
Sbjct: 472 FAVMEEKTILSCILR 486


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  101 bits (252), Expect = 1e-21
 Identities = 117/470 (24%), Positives = 193/470 (41%), Gaps = 44/470 (9%)

Query: 36  LLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAY 95
           LL+A +  L  +Y  R    H +    G+  P    +P+PFLG+A++F K    F    Y
Sbjct: 13  LLLAVSLILLYLYGTRT---HGLFKKLGIPGP----TPLPFLGNALSFRKGYWTFDMECY 65

Query: 96  EKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTT-----PV-FGKGV 149
           +KY  V+      +    +   D    +          ++ YS  T      PV F K  
Sbjct: 66  KKYRKVWGIYDCQQPMLAITDPDMIKTVL--------VKECYSVFTNRRPFGPVGFMKNA 117

Query: 150 AYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGE-------KNVFE 202
                +  +   + +L         K+ V II +       +     E       K+VF 
Sbjct: 118 ISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFG 177

Query: 203 ALSELIILTASH-----CLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFR 257
           A S  +I + S       L+  +     N K    +  LD  F  +  + P   P+    
Sbjct: 178 AYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP-FVLSIKVFPFLTPILEAL 236

Query: 258 RRDRAHREIKDIFYKAIQ-----KRRQSQEKIDDILQTLLDA-TYKDG---RPLTDDEVA 308
                 R++     K+++     + +++Q+   D LQ ++D+   KD    + L+D E+ 
Sbjct: 237 NITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELM 296

Query: 309 GMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNL 368
              I  + AG  T+S+  +++ + LA    +Q+K   E  TV     PP TYD +  L  
Sbjct: 297 AQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPP-TYDTVLQLEY 355

Query: 369 LDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFN 428
           LD  + ETLRL P  M + R+ +    + G  IP G  V +   V       W E   F 
Sbjct: 356 LDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFL 415

Query: 429 PDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF 478
           P+R+ + N  + + + Y PFG+G   CIG  FA V +K     +L+ + F
Sbjct: 416 PERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSF 465


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  101 bits (252), Expect = 1e-21
 Identities = 88/395 (22%), Positives = 165/395 (41%), Gaps = 28/395 (7%)

Query: 111 FTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLN 170
           F  L   D    + N+       ++++ R   P  G+G+     +  +   ++ML    +
Sbjct: 98  FIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDK-WSRHRRMLTPAFH 156

Query: 171 IAHFKQHVSIIEKETKEYFESWGE-----SGEKNVFEALSELIILTASHCL-----HGKE 220
               K +++I  K      + W       S   ++FE +S + + +   C+     H +E
Sbjct: 157 FNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 216

Query: 221 IRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRR-DRAHREIKDIFYKAIQKRRQ 279
             S+    + +L A ++    H    +     L    RR  RA R + D     I++RR+
Sbjct: 217 RPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRR 276

Query: 280 S--------------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTT 325
           +              + K  D +  LL +  +DG+ L+D+++       +  G  T+++ 
Sbjct: 277 TLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASG 336

Query: 326 SAWMGFFLARDKTLQKKCYLEQKTVCGENLPP-LTYDQLKDLNLLDRCIKETLRLRPPIM 384
            +W+ + LAR    Q++C  E + +  +  P  + +D L  L  L  C+KE+LRL PP  
Sbjct: 337 LSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAP 396

Query: 385 IMMRMARTPQTVA-GYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKF 443
            + R       +  G  IP G    +           W +   ++P R+  +N       
Sbjct: 397 FISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPL 456

Query: 444 AYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF 478
           A++PF AG   CIG+ FA  ++K + + ML  + F
Sbjct: 457 AFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRF 491


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 102/469 (21%), Positives = 197/469 (42%), Gaps = 32/469 (6%)

Query: 34  SMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIE--FL 91
           S +L+A     + V+  R    H+     G   P ++   +P        G   ++  FL
Sbjct: 10  SAVLLAFGLCCTFVHRARSRYEHI----PGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFL 65

Query: 92  ENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTP----VFGK 147
           + A +KYGPV    +  KT   +   ++      S   + +++ +Y  L T     +FG+
Sbjct: 66  DWA-KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSK-MYRALQTVFGERLFGQ 123

Query: 148 GVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSEL 207
           G+  +     + +Q++++    + +     +    ++ ++  E      +     ++ ++
Sbjct: 124 GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183

Query: 208 IILTASHCL----HGKEI------RSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFR 257
           +  TA   L     G E       +  L++ V  +   +    +  A  LPG       R
Sbjct: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPG--KRKQLR 241

Query: 258 RRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGML---IGL 314
               + R ++ +    +Q+RR++ ++ +++   +L    K      DDE  G+L   +  
Sbjct: 242 EVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDE--GLLDNFVTF 299

Query: 315 LLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIK 374
            +AG  TS+   A+    L+R   +  +   E   V G     L ++ L  L  L + +K
Sbjct: 300 FIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY-LDFEDLGRLQYLSQVLK 358

Query: 375 ETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQ 434
           E+LRL PP     R+      + G  +P    +  S  V  R+   + + L FNPDR+  
Sbjct: 359 ESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP 418

Query: 435 DNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG 483
             P    +F Y PF  G   CIG+ FA +++K + + +L+  EF L+ G
Sbjct: 419 GAPKP--RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPG 465


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 91/383 (23%), Positives = 165/383 (43%), Gaps = 31/383 (8%)

Query: 130 DLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYF 189
           D  A DVY      + G+G+   +  P +L+ +K+L  G +    K +V++  + T+   
Sbjct: 108 DPKAPDVYDFFLQWI-GRGLLV-LEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIML 165

Query: 190 ESWGESGEK----NVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDG------- 238
           + W E   +    ++F  +  + + T   C  G+      + + +  Y  +         
Sbjct: 166 DKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQ 225

Query: 239 ---GFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS------QEKID---- 285
               F +    +  WL  P  RR  RA +   D   + I++R+ +      ++KI     
Sbjct: 226 RLVSFQYHNDFIY-WLT-PHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRH 283

Query: 286 -DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCY 344
            D L  LL A  +D   L+D ++   +   +  G  T+++  +W  + +A     Q +C 
Sbjct: 284 LDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCR 343

Query: 345 LEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQT-VAGYTIPP 403
            E + + G+      +D L  +  L  CIKE+ RL PP+  + R    P T V G ++P 
Sbjct: 344 EEVREILGDQ-DFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA 402

Query: 404 GHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYV 463
           G  + +      R    W +   F+  R+  +N +    FA++PF AG   CIG+ FA  
Sbjct: 403 GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMS 462

Query: 464 QIKTIWSTMLRLYEFDLIDGYFP 486
           ++K + +  L  +EF L     P
Sbjct: 463 EMKVVTAMCLLRFEFSLDPSRLP 485


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 89/381 (23%), Positives = 159/381 (41%), Gaps = 28/381 (7%)

Query: 130 DLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYF 189
           D  A DVY      + G+G+   +  P +L+ +K+L  G +    K +V++  + T+   
Sbjct: 108 DPKAPDVYDFFLQWI-GRGLLV-LEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIML 165

Query: 190 ESWGESGEK----NVFEALSELIILTASHCLHGKE-------------IRSQLNEKVAQL 232
           + W E   +    ++F  +  + + T   C  G+                S L   + Q 
Sbjct: 166 DKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQR 225

Query: 233 YADLDGGFSHAAWLLPGWLPL-----PSFRRRDRAHREIKDIFY-KAIQKRRQSQEKIDD 286
                       WL P           +    D+  RE K     + ++K+ Q++  + D
Sbjct: 226 LVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHL-D 284

Query: 287 ILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE 346
            L  LL A  +D   L+D ++   +   +  G  T+++  +W  + +A     Q +C  E
Sbjct: 285 FLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREE 344

Query: 347 QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQT-VAGYTIPPGH 405
            + + G+      +D L  +  L  CIKE+ RL PP+  + R    P T V G ++P G 
Sbjct: 345 VREILGDQ-DFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGS 403

Query: 406 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQI 465
            + +      R    W +   F+  R+  +N +    FA++PF AG   CIG+ FA  ++
Sbjct: 404 LISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEM 463

Query: 466 KTIWSTMLRLYEFDLIDGYFP 486
           K + +  L  +EF L     P
Sbjct: 464 KVVTAMCLLRFEFSLDPSRLP 484


>gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 98/438 (22%), Positives = 187/438 (42%), Gaps = 21/438 (4%)

Query: 78  GHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVY 137
           GH +  G     F  +  EKYG VF   ++G+    + G++    +   ++  ++ E  +
Sbjct: 63  GHWLLQGSG---FQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTE--W 117

Query: 138 SRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGE 197
            R T  + G     +    +   ++K+     +    + ++  I+   ++   +W    E
Sbjct: 118 PRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPE 177

Query: 198 K-NVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYAD-LDGGFSHAAWLLPGWLPLPS 255
             NV++   +L    A   L G  I  +    + ++Y   +D  FS     LP  LP   
Sbjct: 178 AINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFS-----LPVDLPFSG 232

Query: 256 FRRRDRAHREIKDIFYKAIQKRRQSQEKID--DILQTLLDATYKDGRPLTDDEVAGMLIG 313
           +RR  +A + ++    KAI+++ Q  +  D  D L  L++++ + G+ +T  E+    + 
Sbjct: 233 YRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLE 292

Query: 314 LLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKT---VCGENLP---PLTYDQLKDLN 367
           L+ A   T+++ S  +   L +  T+ +K   E +    +     P    L  D L  L 
Sbjct: 293 LIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLR 352

Query: 368 LLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDF 427
            LD  IKE +RL  PI    R       + G+ IP G  V  S          + +   F
Sbjct: 353 YLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVF 412

Query: 428 NPDRYLQDNPASGE-KFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFP 486
           +PDR+ Q      + +F Y+PFG G   C+G++ A + +K +   +     F+L    FP
Sbjct: 413 DPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFP 472

Query: 487 TVNYTTMIHTPENPVIRY 504
            +    ++H  +   +++
Sbjct: 473 RITLVPVLHPVDGLSVKF 490


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 88/388 (22%), Positives = 164/388 (42%), Gaps = 35/388 (9%)

Query: 118 DAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQH 177
           D    + N+ +   + + V+ +   P  G G+   V +  +   +++L    +    K +
Sbjct: 105 DIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDK-WRHHRRLLTPAFHFNILKPY 163

Query: 178 VSIIEKETKEYFESWGESGEK-----NVFEALSELIILTASHCLHGKEIRSQ-------- 224
           + I  K        W     +     +VFE +S + + +   C+   +   Q        
Sbjct: 164 IKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYIT 223

Query: 225 -LNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS--Q 281
            + E  A +    +  F +  +L   +   P  RR  RA R + D     IQ+RR++   
Sbjct: 224 AIMELSALVVKRNNQFFRYKDFL---YFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTS 280

Query: 282 EKIDDILQT------------LLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWM 329
           + +DD LQ             LL +  K+G+ L+D+++       +  G  T+++  +W+
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWV 340

Query: 330 GFFLARDKTLQKKCYLEQKTVCGENLPP-LTYDQLKDLNLLDRCIKETLRLRPPIMIMMR 388
            + LAR    Q++C  E + +  +  P  + +D L  L  L  C+KE+LRL PPI    R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFAR 400

Query: 389 MARTPQTVAGYTIPPGHQVC-VSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVP 447
                  +    + P   VC ++          W +   ++P R+  +N       A++P
Sbjct: 401 GCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIP 460

Query: 448 FGAGRHRCIGENFAYVQIKTIWS-TMLR 474
           F AG   CIG+ FA  ++K + + T+LR
Sbjct: 461 FSAGPRNCIGQKFAMAEMKVVLALTLLR 488


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 109/477 (22%), Positives = 206/477 (43%), Gaps = 56/477 (11%)

Query: 35  MLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIP---FLGHAIAFGKSPIEFL 91
           +LLI    +L L  +IRL       + A      ++F   P   F GH   +     E  
Sbjct: 15  LLLILLCMSLLLFQVIRLYQRRRWMIRA-----LHLFPAPPAHWFYGHKEFYPVKEFEVY 69

Query: 92  ENAYEKY--------GPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTP 143
               EKY        GP   FTM    F  +   D A +L   K +D  +   +  L + 
Sbjct: 70  HKLMEKYPCAVPLWVGP---FTM----FFSVHDPDYAKILL--KRQDPKSAVSHKILESW 120

Query: 144 VFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKN---- 199
           V G+G+   +    + + ++++K G NI+  K  ++++ +  +     W E   +N    
Sbjct: 121 V-GRGLV-TLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLE 178

Query: 200 VFEALSELIILTASHCLHGKEIRSQLNE----------KVAQLYADLDGGFSHAAWLLPG 249
           +F+ +S + + +   C    +   QL+            ++++       F H   L+  
Sbjct: 179 LFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFK 238

Query: 250 WLPLPSFRRRDRAHREIKDIFYKAIQKRRQS----------QEKIDDILQTLLDATYKDG 299
           +          + ++E+     K IQ R++S          Q++  D L  LL A  ++ 
Sbjct: 239 FSSQGQIF--SKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENT 296

Query: 300 RPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLT 359
           +  ++ ++   +   + AG  T+S+  +W+ + LA+    Q++C  E + + G+    +T
Sbjct: 297 KDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDG-SSIT 355

Query: 360 YDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGHQVCVSPTVNQRLK 418
           ++ L  +     CIKE LRL  P++ + R+   P T   G ++P G  V ++        
Sbjct: 356 WEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNP 415

Query: 419 DSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIK-TIWSTMLR 474
             W +   FNP R+ ++N      +A++PF AG   CIG++FA ++ K  +  T+LR
Sbjct: 416 YFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLR 472


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 113/506 (22%), Positives = 193/506 (38%), Gaps = 43/506 (8%)

Query: 24  MEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAF 83
           M+ +    + + +L+A +  L  +Y       H +    G+  P    +P+PFLG  + +
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTH---SHKLFKKLGIPGP----TPLPFLGTILFY 53

Query: 84  GKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTP 143
            +    F     EKYG ++      +    ++  D    +          ++ YS  T  
Sbjct: 54  LRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVL--------VKECYSVFTNQ 105

Query: 144 V------FGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGE 197
           +      F K       +  +   + +L        FK+ V II +       S  +  E
Sbjct: 106 MPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAE 165

Query: 198 K----NVFEALSELIILTASHCLHGKEIRSQLNEK-------VAQLYADLDGGFSHAAWL 246
                N+ +      +   +  L G  + S  N +          L  D    F     L
Sbjct: 166 NSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISL 225

Query: 247 LPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKID-----DILQTLLDATY----K 297
            P   P+          +++      +I++ ++S+ K       D  Q ++D+      K
Sbjct: 226 FPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETK 285

Query: 298 DGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPP 357
             + L+D E+    I ++ A   T+STT  ++ + LA    +Q+K   E   V   N  P
Sbjct: 286 SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAP 344

Query: 358 LTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRL 417
           +TYD L  +  LD  + ETLRL P +  + R+ +    + G  IP G  V V        
Sbjct: 345 VTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHD 404

Query: 418 KDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE 477
              W E   F P+R+ + N  S + + Y+PFGAG   CIG  FA   IK      L+ + 
Sbjct: 405 PKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFS 464

Query: 478 F-DLIDGYFPTVNYTTMIHTPENPVI 502
           F    +   P       I  PE P++
Sbjct: 465 FKPCKETQIPLKLDNLPILQPEKPIV 490


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 78/344 (22%), Positives = 146/344 (42%), Gaps = 37/344 (10%)

Query: 162 KKMLKSGLNIAHFKQHVSIIEKETKEYFESWGE-----SGEKNVFEALSELIILTASHCL 216
           ++ML    +    K ++ I  K      + W       S   ++FE +S + + +   C+
Sbjct: 148 RRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCV 207

Query: 217 HGKEIRSQLNEKVAQLYADL-----------DGGFSHAAWLLPGWLPLPSFRRRDRAHRE 265
              E  S   EK ++  A +                H  +L   +   P  +R  RA   
Sbjct: 208 FSFE--SNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFL---YYLTPDGQRFRRACHL 262

Query: 266 IKDIFYKAIQKRR--------------QSQEKIDDILQTLLDATYKDGRPLTDDEVAGML 311
           + D     IQ+RR              +++ K  D +  LL +  +DG+ L+D+++    
Sbjct: 263 VHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEA 322

Query: 312 IGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLP-PLTYDQLKDLNLLD 370
              +  G  T+++  +W+ + LA+    Q++C  E + +  +  P  + +D L  L  L 
Sbjct: 323 DTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLT 382

Query: 371 RCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS-WVERLDFNP 429
            CIKE+LRL PP+ ++ R       +    + P   VC+   +      + W +   ++P
Sbjct: 383 MCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDP 442

Query: 430 DRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTML 473
            R+ Q+N       A++PF AG   CIG+ FA  ++K + +  L
Sbjct: 443 FRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTL 486


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 78/344 (22%), Positives = 146/344 (42%), Gaps = 37/344 (10%)

Query: 162 KKMLKSGLNIAHFKQHVSIIEKETKEYFESWGE-----SGEKNVFEALSELIILTASHCL 216
           ++ML    +    K ++ I  K      + W       S   ++FE +S + + +   C+
Sbjct: 148 RRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCV 207

Query: 217 HGKEIRSQLNEKVAQLYADL-----------DGGFSHAAWLLPGWLPLPSFRRRDRAHRE 265
              E  S   EK ++  A +                H  +L   +   P  +R  RA   
Sbjct: 208 FSFE--SNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFL---YYLTPDGQRFRRACHL 262

Query: 266 IKDIFYKAIQKRR--------------QSQEKIDDILQTLLDATYKDGRPLTDDEVAGML 311
           + D     IQ+RR              +++ K  D +  LL +  +DG+ L+D+++    
Sbjct: 263 VHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEA 322

Query: 312 IGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLP-PLTYDQLKDLNLLD 370
              +  G  T+++  +W+ + LA+    Q++C  E + +  +  P  + +D L  L  L 
Sbjct: 323 DTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLT 382

Query: 371 RCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS-WVERLDFNP 429
            CIKE+LRL PP+ ++ R       +    + P   VC+   +      + W +   ++P
Sbjct: 383 MCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDP 442

Query: 430 DRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTML 473
            R+ Q+N       A++PF AG   CIG+ FA  ++K + +  L
Sbjct: 443 FRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTL 486


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 65/238 (27%), Positives = 114/238 (47%), Gaps = 17/238 (7%)

Query: 254 PSFRRRDRAHREIKDIFYKAIQKRRQS--QEKIDDILQT------------LLDATYKDG 299
           P  +R  RA R + D     IQ+RR++   + +DD LQ             LL +  +DG
Sbjct: 251 PDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDG 310

Query: 300 RPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPP-L 358
           + L+D+++       +  G  T+++  +W+ + LA+    Q++C  E + +  +  P  +
Sbjct: 311 KKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEI 370

Query: 359 TYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGHQVCVSPTVNQRL 417
            +D L  L  L  C+KE+LRL PP+ ++ R       +  G  IP G    +S       
Sbjct: 371 EWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHN 430

Query: 418 KDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWS-TMLR 474
              W +   ++P R+  +N       A++PF AG   CIG+ FA  ++K + + T+LR
Sbjct: 431 PAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLR 488


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 66/238 (27%), Positives = 111/238 (46%), Gaps = 17/238 (7%)

Query: 254 PSFRRRDRAHREIKDIFYKAIQKRRQS--QEKIDDILQT------------LLDATYKDG 299
           P  +R  RA R + D     IQ+RR++   + +DD LQ             LL +  +DG
Sbjct: 251 PDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDG 310

Query: 300 RPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLP-PL 358
           + L+D+++       +  G  T+++  +W+ + LA+    Q++C  E + +  +  P  +
Sbjct: 311 KKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEI 370

Query: 359 TYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGHQVCVSPTVNQRL 417
            +D L  L  L  CIKE+LRL PP+  + R       +  G  IP G    +S       
Sbjct: 371 EWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHN 430

Query: 418 KDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWS-TMLR 474
              W +   ++P R+   N       A++PF AG   CIG+ FA  ++K +   T+LR
Sbjct: 431 PAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLR 488


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 111/494 (22%), Positives = 195/494 (39%), Gaps = 44/494 (8%)

Query: 36  LLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAY 95
           LL+A +  L  +Y  R    H +    G+  P    +P+P LG+ +++ +   +F    Y
Sbjct: 13  LLLAVSLVLLYLYGTRT---HGLFKRLGIPGP----TPLPLLGNVLSYRQGLWKFDTECY 65

Query: 96  EKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTT-----PV-FGKGV 149
           +KYG ++         TY       A+        +  ++ YS  T      PV F K  
Sbjct: 66  KKYGKMWG--------TYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSA 117

Query: 150 AYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEK-------NVFE 202
                +  +   + +L         K+   II +       +     EK       ++F 
Sbjct: 118 ISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFG 177

Query: 203 ALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWL----LPGWLPLPSFRR 258
           A S  +I   S  ++   + +  +  V      L  GF    +L     P   P+     
Sbjct: 178 AYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALN 237

Query: 259 RDRAHREIKDIFYKAIQKRRQS-----QEKIDDILQTLLDATY----KDGRPLTDDEVAG 309
                ++  +   K++ + ++S     Q+   D LQ ++D+      +  + L+D E+A 
Sbjct: 238 VSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAA 297

Query: 310 MLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLL 369
             I  + AG  T+S+  ++  + LA    +Q+K   E   V     PP TYD +  +  L
Sbjct: 298 QSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP-TYDAVVQMEYL 356

Query: 370 DRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNP 429
           D  + ETLRL P  + + R  +    + G  IP G  V +           W E  +F P
Sbjct: 357 DMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416

Query: 430 DRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF-DLIDGYFPTV 488
           +R+ +    S + + Y PFG G   CIG  FA + +K     +L+ + F    +   P  
Sbjct: 417 ERFSKKKD-SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 475

Query: 489 NYTTMIHTPENPVI 502
             T  +  PE P++
Sbjct: 476 LDTQGLLQPEKPIV 489


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 100/460 (21%), Positives = 193/460 (41%), Gaps = 47/460 (10%)

Query: 59  QLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSD 118
           Q+P G+K+PP  +   P +GH +  GK+P   L    ++YG V    +       L G D
Sbjct: 32  QVPKGLKNPPGPWG-WPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLD 90

Query: 119 AAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPN-PVFLEQKKMLKSGLNI------ 171
                   + +D          T    G+ +++   + PV+  ++++ ++GL        
Sbjct: 91  TIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASD 150

Query: 172 ------AHFKQHVSIIEKETKEYFESWGE----SGEKNVFEALSELIILTASHCLHGKEI 221
                  + ++HVS   KE +    +  E     G  N +  +   +         G+  
Sbjct: 151 PASSTSCYLEEHVS---KEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207

Query: 222 RSQLNEKVAQL-----YADLDGGFSHAAWL-LPGWLPLPSFRRRDRAHREIKDIFYKAIQ 275
                E ++ +     + ++ G  + A ++ +  +LP PS      A +++ + FY  +Q
Sbjct: 208 DHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLN----AFKDLNEKFYSFMQ 263

Query: 276 KRRQSQEK------IDDILQTLLDATYKD------GRPLTDDEVAGMLIGLLLAGQHTSS 323
           K  +   K      I DI  +L++   +          L+D+++  +++ L  AG  T +
Sbjct: 264 KMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVT 323

Query: 324 TTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPI 383
           T  +W   +L  +  +Q+K   E  TV G +  P   D+   L  ++  I ET R    +
Sbjct: 324 TAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR-SHLPYMEAFILETFRHSSFV 382

Query: 384 MIMMRMARTPQT-VAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEK 442
              +  + T  T + G+ IP G  V V+       +  WV   +F P+R+L  + A  + 
Sbjct: 383 PFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKV 442

Query: 443 FA--YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL 480
            +   + FG G+ +CIGE  A  ++    + +L+  EF +
Sbjct: 443 LSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 113/507 (22%), Positives = 193/507 (38%), Gaps = 44/507 (8%)

Query: 24  MEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAF 83
           M+ +    + + +L+A +  L  +Y       H +    G+  P    +P+PFLG  + +
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTH---SHKLFKKLGIPGP----TPLPFLGTILFY 53

Query: 84  GKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTP 143
            +    F     EKYG ++      +    ++  D    +          ++ YS  T  
Sbjct: 54  LRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVL--------VKECYSVFTNQ 105

Query: 144 V------FGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGE 197
           +      F K       +  +   + +L        FK+ V II +       S  +  E
Sbjct: 106 MPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAE 165

Query: 198 K----NVFEALSELIILTASHCLHGKEIRSQLNEK-------VAQLYADLDGGFSHAAWL 246
                N+ +      +   +  L G  + S  N +          L  D    F     L
Sbjct: 166 NSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISL 225

Query: 247 LPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKID-----DILQTLLDATY----K 297
            P   P+          +++      +I++ ++S+ K       D  Q ++D+      K
Sbjct: 226 FPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETK 285

Query: 298 DGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPP 357
             + L+D E+    I ++ A   T+STT  ++ + LA    +Q+K   E   V   N  P
Sbjct: 286 SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAP 344

Query: 358 LTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRL 417
           +TYD L  +  LD  + ETLRL P +  + R+ +    + G  IP G  V V        
Sbjct: 345 VTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHD 404

Query: 418 KDSWVERLDFNPD-RYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLY 476
              W E   F P+ R+ + N  S + + Y+PFGAG   CIG  FA   IK      L+ +
Sbjct: 405 PKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 464

Query: 477 EF-DLIDGYFPTVNYTTMIHTPENPVI 502
            F    +   P       I  PE P++
Sbjct: 465 SFKPCKETQIPLKLDNLPILQPEKPIV 491


>gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 122/485 (25%), Positives = 200/485 (41%), Gaps = 59/485 (12%)

Query: 43  TLSLVYLIRLAAGHLVQLPAGVK-----SPPYIFSPIPFLGHAIAFGKSPIEFLENAYEK 97
           T SL++ I +AA   + L  G++      PP     IP+LG A+ FG +P+EFL     K
Sbjct: 3   TTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRK 62

Query: 98  YGPVFSFTMVGKTFTYLLGS-DAAALLFNSKNED-------LNAEDVYSRLTTPVFGKGV 149
           +G VF+  ++GK   ++        +L + K  D        +A+    R   P+ G   
Sbjct: 63  HGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTT 122

Query: 150 AYDVPNPVFLEQKKMLKSGLN-----IAHFKQHVSIIEKETKEYFESWGESGEKNV-FEA 203
             +  N  F+  K +    LN     +    Q +      +     +W   G  +  +  
Sbjct: 123 --ENINDTFI--KTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRV 178

Query: 204 LSELIILTASHCLHGKEIRSQLNEKVAQLYADLDG--GFSHAAWLLPGWLPLPSFRRRDR 261
           + E   LT    + G+++  +  +K A +  +LD    F      L   LP+  FR    
Sbjct: 179 MFEAGYLT----IFGRDLTRRDTQK-AHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHN 233

Query: 262 AHREIKD-IFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQH 320
           A  ++ + + ++ +QKR    E I   L+  L+ T        D E A   + +L A Q 
Sbjct: 234 AREKLAESLRHENLQKRESISELIS--LRMFLNDTLST---FDDLEKAKTHLVVLWASQA 288

Query: 321 TSSTTSAWMGFFLARDKTLQKKCYLE---------QKTVCGENLPPLTYDQLKDLNLLDR 371
            +   + W  F + R+    K    E         QK     N   L+  +L DL +LD 
Sbjct: 289 NTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDS 348

Query: 372 CIKETLRLRPPIMIMMRMARTPQTV----AGYTIPPGHQVCVSPTVNQRLKDSWVERLDF 427
            IKE+LRL     + +R A+   T+      Y I     + + P +     + + + L F
Sbjct: 349 IIKESLRLSSA-SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTF 407

Query: 428 NPDRYLQDNPASGE---------KFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF 478
             DRYL +N  +           K+ Y+PFG+G   C G  FA  +IK     ML  +E 
Sbjct: 408 KYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFEL 467

Query: 479 DLIDG 483
           +LI+G
Sbjct: 468 ELIEG 472


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 50/181 (27%), Positives = 91/181 (50%), Gaps = 2/181 (1%)

Query: 302 LTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYD 361
           L+  E+   +  L LA   T++ +  W+ + L+R+  +Q+K   E ++V  EN  P   D
Sbjct: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAED 370

Query: 362 QLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSW 421
            L+++  L  C+KE++RL P +    R       +  Y +P G  + ++  V    +D++
Sbjct: 371 -LRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNF 429

Query: 422 VERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLI 481
            +   F P+R+LQ+       FA++PFG G+  CIG   A +Q+      ++R Y+    
Sbjct: 430 EDSSQFRPERWLQEKEKI-NPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQAT 488

Query: 482 D 482
           D
Sbjct: 489 D 489


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 104/481 (21%), Positives = 190/481 (39%), Gaps = 41/481 (8%)

Query: 36  LLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAY 95
           LL+A A    + ++++   G   ++P G+KSPP  +   P LGH +  GK+P   L    
Sbjct: 14  LLLASAIFCLVFWVLK---GLRPRVPKGLKSPPEPWG-WPLLGHVLTLGKNPHLALSRMS 69

Query: 96  EKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPN 155
           ++YG V    +       L   D        + +D          T    G+ + +   +
Sbjct: 70  QRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDS 129

Query: 156 -PVFLEQKKMLKSGLNI------------AHFKQHVSIIEKETKEYFESWGE-SGEKNVF 201
            PV+  ++++ ++ LN              + ++HVS   KE K       E       F
Sbjct: 130 GPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVS---KEAKALISRLQELMAGPGHF 186

Query: 202 EALSELIILTAS---------HCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLP 252
           +  +++++  A+         H     +    L +   +       G     + +  +LP
Sbjct: 187 DPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLP 246

Query: 253 LPSFRRRDRAHREIKDIFYKAIQKRRQSQEK--IDDILQTLLDATYK----DGRPLTDDE 306
            P+ +R    ++       K +Q+  Q  +K  + DI   L   + K     G  +  ++
Sbjct: 247 NPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEK 306

Query: 307 VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDL 366
           +  ++  +  AG  T +T  +W   +L     +Q+K   E  TV G    P   D+   L
Sbjct: 307 IVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDR-PQL 365

Query: 367 NLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGHQVCVSPTVNQRLKDSWVERL 425
             L+  I ET R    +   +  + T  T   G+ IP    V V+        + W +  
Sbjct: 366 PYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPS 425

Query: 426 DFNPDRYLQ-DNPASGEKFA--YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLID 482
           +F P+R+L  D  A  +  +   + FG G+ RCIGE  A  +I    + +L+  EF +  
Sbjct: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 485

Query: 483 G 483
           G
Sbjct: 486 G 486


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 98/426 (23%), Positives = 175/426 (41%), Gaps = 45/426 (10%)

Query: 87  PIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDL--NAEDVYSRLTTPV 144
           P   L +    YG +FSF  +G     +L        F+S  E L   AE    R   P+
Sbjct: 103 PQVLLAHLARVYGSIFSF-FIGHYLVVVLSD------FHSVREALVQQAEVFSDRPRVPL 155

Query: 145 FG-----KGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKN 199
                  KGV +    PV+ +Q+K   S L   HF      +E +  E F+      +K+
Sbjct: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLR--HFGLGKLSLEPKIIEEFKYVKAEMQKH 213

Query: 200 ------VFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF-----------SH 242
                  F  +S  +         G+      N +  ++   +  G            + 
Sbjct: 214 GEDPFCPFSIISNAVSNIICSLCFGQRF-DYTNSEFKKMLGFMSRGLEICLNSQVLLVNI 272

Query: 243 AAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS------QEKIDDILQTLLDATY 296
             WL   +LP   F+   +  ++I     K I+  ++S      Q+ ID  L  + +   
Sbjct: 273 CPWLY--YLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERK 330

Query: 297 KDGRPLTDDEVAGMLIG-LLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENL 355
            +     D+E    +IG L +AG  T++ +  W   +++ +  +Q+K + E + V G N 
Sbjct: 331 NNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANR 390

Query: 356 PPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGHQVCVSPTVN 414
            P   D+ + +   +  I E  RL   + + +    +  TV  GYTIP G  +  +    
Sbjct: 391 APSLTDKAQ-MPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSV 449

Query: 415 QRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLR 474
            R    W +  DF P+R+L D     +K  ++PFG G+  C+GE  A +++  ++ ++++
Sbjct: 450 HRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQ 509

Query: 475 LYEFDL 480
            + F L
Sbjct: 510 SFAFAL 515


>gi|62952502 cytochrome P450, family 26, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 522

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 92/454 (20%), Positives = 182/454 (40%), Gaps = 44/454 (9%)

Query: 75  PFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAE 134
           PF G  + +      F  +  E+YG VF   ++G+    + G++    +   ++  + ++
Sbjct: 57  PFFGETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQ 116

Query: 135 DVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESW-G 193
             + +    + G              ++K+L    + A  +++V  ++   +    SW  
Sbjct: 117 --WPQSAHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCA 174

Query: 194 ESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADL-DGGFSHAAWLLPGWLP 252
             G  +V++A   L    A+  L G  +       +A+ +  L +  FS     LP  +P
Sbjct: 175 AGGPVSVYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFS-----LPLDVP 229

Query: 253 LPSFRR----RDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVA 308
               R+    RD+ HR ++    + + + + ++    D L  ++ +  + G   +  E+ 
Sbjct: 230 FSGLRKGIRARDQLHRHLEGAISEKLHEDKAAEP--GDALDLIIHSARELGHEPSMQELK 287

Query: 309 GMLIGLLLAGQHTSSTTSAWMGFFLARDKT-------------LQKKCYLEQKTVCGENL 355
              + LL A   T+++ S  +   L +                L + C        G   
Sbjct: 288 ESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEG 347

Query: 356 PP--------LTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQV 407
           PP        L+   L  L  +D  +KE LRL PP+    R A     + GY IP G  V
Sbjct: 348 PPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSV 407

Query: 408 CVSPTVNQRLKDSWVERLD---FNPDRY---LQDNPASGEKFAYVPFGAGRHRCIGENFA 461
             S  +    + + V R     F+P+R+    +D+  +  +F Y+PFG G   C+G+  A
Sbjct: 408 MYS--IRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELA 465

Query: 462 YVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIH 495
              ++ +   ++R   ++L    FP +    ++H
Sbjct: 466 QAVLQLLAVELVRTARWELATPAFPAMQTVPIVH 499


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,205,332
Number of Sequences: 37866
Number of extensions: 930429
Number of successful extensions: 2149
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1965
Number of HSP's gapped (non-prelim): 106
length of query: 509
length of database: 18,247,518
effective HSP length: 107
effective length of query: 402
effective length of database: 14,195,856
effective search space: 5706734112
effective search space used: 5706734112
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.