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Search of human proteins with 4503211
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide
1 precursor [Homo sapiens]
(531 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ... 1080 0.0
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 365 e-101
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid... 290 2e-78
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 262 7e-70
gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1... 204 1e-52
gi|153218646 cytochrome P450, family 11, subfamily A, polypeptid... 204 1e-52
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide... 194 1e-49
gi|119829183 cytochrome P450, family 11, subfamily B, polypeptid... 187 3e-47
gi|153218654 cytochrome P450, family 11, subfamily A, polypeptid... 174 2e-43
gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide... 141 1e-33
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 132 1e-30
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 123 5e-28
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 118 1e-26
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 118 2e-26
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 114 3e-25
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 113 5e-25
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 111 2e-24
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 110 4e-24
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 107 3e-23
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ... 106 6e-23
gi|5729796 cytochrome P450, family 46 [Homo sapiens] 106 6e-23
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 105 1e-22
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide... 101 1e-21
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 101 1e-21
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 101 1e-21
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ... 99 7e-21
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 97 3e-20
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 97 3e-20
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ... 97 4e-20
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid... 96 8e-20
>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
precursor [Homo sapiens]
Length = 531
Score = 1080 bits (2793), Expect = 0.0
Identities = 531/531 (100%), Positives = 531/531 (100%)
Query: 1 MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAPGAGPGVRRRQRSLEEI 60
MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAPGAGPGVRRRQRSLEEI
Sbjct: 1 MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAPGAGPGVRRRQRSLEEI 60
Query: 61 PRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQ 120
PRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQ
Sbjct: 61 PRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQ 120
Query: 121 EGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNE 180
EGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNE
Sbjct: 121 EGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNE 180
Query: 181 VIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTF 240
VIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTF
Sbjct: 181 VIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTF 240
Query: 241 VRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAA 300
VRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAA
Sbjct: 241 VRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAA 300
Query: 301 GPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEA 360
GPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEA
Sbjct: 301 GPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEA 360
Query: 361 LHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPK 420
LHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPK
Sbjct: 361 LHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPK 420
Query: 421 NTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRR 480
NTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRR
Sbjct: 421 NTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRR 480
Query: 481 IAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQRQC 531
IAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQRQC
Sbjct: 481 IAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQRQC 531
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 365 bits (936), Expect = e-101
Identities = 199/494 (40%), Positives = 285/494 (57%), Gaps = 16/494 (3%)
Query: 45 GAGPGVRR---RQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLG 101
GA G R +RSL +IP F +LF +G +LH+LQV A +GP+W++ G
Sbjct: 22 GASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFG 81
Query: 102 PQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQAL 161
V +A+ L+E+++RQEG P R W EHR G T EG W +LR L
Sbjct: 82 TVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLL 141
Query: 162 NQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQ-VSDMAQLFYYFALEAICYI 220
LL+P AA Y N V+ D + RL + R V D+A FY F LE I +
Sbjct: 142 APLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAV 201
Query: 221 LFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPF-WKRYLDGWNAIF 279
L R+GCL+ +P DT TF+R++G +F ++L +P W R ++P W R W+ +F
Sbjct: 202 LLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMF 261
Query: 280 SFGKKLIDEKLEDMEAQLQAAGPD--GIQVSGYLHFLLASGQLSPREAMGSLPELLMAGV 337
+F ++ ++ + + EA ++ G ++ +L L +L + +G++ ELL+AGV
Sbjct: 262 AFAQRHVERR--EAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGV 319
Query: 338 DTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQ--VPQHKDFAHMPLLKAVLKETLR 395
DT SNTL+WALY LS+ PE+Q ALH E+ + G P + +PLLKAV+KE LR
Sbjct: 320 DTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLR 379
Query: 396 LYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQP 455
LYPVVP NSR+ +K+I V ++ PKNT CHY SRDP F EP SF+P RWL +
Sbjct: 380 LYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWL--GEG 437
Query: 456 ATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIV 515
TP HPF S+PFG+G R+C+GRR+AELE+Q+ LA+++ ++V P ++ R V
Sbjct: 438 PTP---HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTV 494
Query: 516 LVPNKKVGLQFLQR 529
LVP + + LQFL R
Sbjct: 495 LVPERSINLQFLDR 508
>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
[Homo sapiens]
Length = 372
Score = 290 bits (743), Expect = 2e-78
Identities = 143/379 (37%), Positives = 241/379 (63%), Gaps = 12/379 (3%)
Query: 157 LRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEA 216
+R L QR+LKP + A+Y+ N+VI D + R+ LR+++ G V+++ LF+ +++E
Sbjct: 1 MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEG 60
Query: 217 ICYILFEKRIGCLQRSIPEDTVTFVRSIGLMF---QNSLYATFLPKWTRPVLPF-WKRYL 272
+ IL+E R+GCL+ SIP+ TV ++ ++ LMF + S+YA +P+W RP +P W+ +
Sbjct: 61 VATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFC 120
Query: 273 DGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSG-YLHFLLASGQLSPREAMGSLPE 331
W+ +F F + +D KL D++ Q+ G +VSG L +L S L+ +E ++ E
Sbjct: 121 RSWDGLFKFSQIHVDNKLRDIQYQMDR----GRRVSGGLLTYLFLSQALTLQEIYANVTE 176
Query: 332 LLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLK 391
+L+AGVDTTS TL+W +Y L++ PE+Q+ ++ E+V + VP D +PL++A+LK
Sbjct: 177 MLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLK 236
Query: 392 ETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLR 451
ETLRL+PV+P N R+ ++++ + G+L PK TQ CHY S F + F+P RWLR
Sbjct: 237 ETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLR 296
Query: 452 NSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSV 511
R+ + FGS+PFG+GVR+C+GRRIAELE+ L++ +L+Q +++ + +T + +
Sbjct: 297 KGD--LDRVDN-FGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAK 353
Query: 512 ARIVLVPNKKVGLQFLQRQ 530
+L P + ++F+ R+
Sbjct: 354 THGLLTPGGPIHVRFVNRK 372
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 262 bits (669), Expect = 7e-70
Identities = 158/476 (33%), Positives = 249/476 (52%), Gaps = 33/476 (6%)
Query: 61 PRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQ 120
P LG L Q+ +G + H V Y KYG ++ LG V+L S LLE + R
Sbjct: 65 PLLGSL---LQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRT 121
Query: 121 EGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNE 180
E YP R +++ WK +RD YG EG W ++R A ++L+KP E + NE
Sbjct: 122 ESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINE 181
Query: 181 VIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTF 240
V+ DFM R+D+L E V D+ ++ E+IC +L+EKR G LQ++ ++ V F
Sbjct: 182 VLADFMGRIDELCDERG---HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNF 238
Query: 241 VRSIGLMFQNSLYATFLPKWTRPV-------LPFWKRYLDGWNAIFSFGKKLIDEKLEDM 293
+ +I M +TF PV W+ + W+ IF K ID +LE
Sbjct: 239 IMAIKTMM-----STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKY 293
Query: 294 EAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSK 353
Q A +L + +LS +E ++ EL +A V+TT+N+L W LY+LS+
Sbjct: 294 SQQPSA---------DFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSR 344
Query: 354 DPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV 413
+P++Q+ L +E+ V+P QVP+ +D +MP LKA LKE++RL P VP +R ++K +
Sbjct: 345 NPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVL 404
Query: 414 DGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGV 473
+ PK T + V+ F + F+P RWL+ + +PF +PFG G
Sbjct: 405 GEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI-----NPFAHLPFGVGK 459
Query: 474 RACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQR 529
R C+GRR+AEL++ L L +++KY + A + ++ + LVP++++ + F QR
Sbjct: 460 RMCIGRRLAELQLHLALCWIVRKYD-IQATDNEPVEMLHSGTLVPSRELPIAFCQR 514
>gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 448
Score = 204 bits (520), Expect = 1e-52
Identities = 129/397 (32%), Positives = 198/397 (49%), Gaps = 27/397 (6%)
Query: 61 PRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQ 120
P LG L Q+ +G + H V Y KYG ++ LG V+L S LLE + R
Sbjct: 65 PLLGSL---LQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRT 121
Query: 121 EGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNE 180
E YP R +++ WK +RD YG EG W ++R A ++L+KP E + NE
Sbjct: 122 ESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINE 181
Query: 181 VIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTF 240
V+ DFM R+D+L E V D+ ++ E+IC +L+EKR G LQ++ ++ V F
Sbjct: 182 VLADFMGRIDELCDERG---HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNF 238
Query: 241 VRSIGLMFQNSLYATFLPKWTRPV-------LPFWKRYLDGWNAIFSFGKKLIDEKLEDM 293
+ +I M +TF PV W+ + W+ IF K ID +LE
Sbjct: 239 IMAIKTMM-----STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKY 293
Query: 294 EAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSK 353
Q A +L + +LS +E ++ EL +A V+TT+N+L W LY+LS+
Sbjct: 294 SQQPSA---------DFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSR 344
Query: 354 DPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV 413
+P++Q+ L +E+ V+P QVP+ +D +MP LKA LKE++RL P VP +R ++K +
Sbjct: 345 NPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVL 404
Query: 414 DGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWL 450
+ PK + +P + P R L
Sbjct: 405 GEYALPKGIVRKYDIQATDNEPVEMLHSGTLVPSREL 441
>gi|153218646 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform a precursor [Homo sapiens]
Length = 521
Score = 204 bits (520), Expect = 1e-52
Identities = 140/489 (28%), Positives = 233/489 (47%), Gaps = 19/489 (3%)
Query: 45 GAGPGVRRRQ-RSLEEIPRLGQLR----FFFQLFVQGYALQLHQLQVLYKAKYGPMWMSY 99
G G G+ R R EIP G + F + + LH +Q K YGP++
Sbjct: 35 GEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQK--YGPIYREK 92
Query: 100 LGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQ 159
LG V + + + + EG P R + W + + G + W + R
Sbjct: 93 LGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRV 152
Query: 160 ALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICY 219
ALNQ ++ P + + V DF++ L + ++ SGN D++ + FA E+I
Sbjct: 153 ALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITN 212
Query: 220 ILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVL--PFWKRYLDGWNA 277
++F +R G L+ + + F+ +I MF S+ LP + WK ++ W+
Sbjct: 213 VIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDV 272
Query: 278 IFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGV 337
IFS D ++ +L+ G G L+ LL ++S + ++ E+L GV
Sbjct: 273 IFSKA----DIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGV 328
Query: 338 DTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLY 397
DTTS TL W LY ++++ ++Q+ L EV+ Q +PLLKA +KETLRL+
Sbjct: 329 DTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLH 388
Query: 398 PVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPAT 457
P+ T R + ++ + ++ P T Y + R+PT F +PE+F P RWL + T
Sbjct: 389 PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNIT 448
Query: 458 PRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLV 517
F ++ FG+GVR CLGRRIAELEM + L +++ ++V + ++ + ++L+
Sbjct: 449 -----YFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI-QHLSDVGTTFNLILM 502
Query: 518 PNKKVGLQF 526
P K + F
Sbjct: 503 PEKPISFTF 511
>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 503
Score = 194 bits (494), Expect = 1e-49
Identities = 146/509 (28%), Positives = 240/509 (47%), Gaps = 35/509 (6%)
Query: 26 RAKAAIPAALPSDKATGAPGAGPGVRRRQRSL---EEIPRLGQLRFFFQLFV---QGYA- 78
RAKA + A+P A G R R++ E +PR R+ L + QGY
Sbjct: 4 RAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYED 63
Query: 79 --LQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEH 136
L++HQ + GP++ LG V + +E++ + + +P R +E W +
Sbjct: 64 LHLEVHQTF----QELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY 119
Query: 137 RDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAES 196
R G F G W R LN +L P + + V DF L + ++
Sbjct: 120 RQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQN 179
Query: 197 ASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATF 256
A G+ D+ +++ +EA LF +R+G + S ++ F+ ++ +MF++++ F
Sbjct: 180 ARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMF 239
Query: 257 LPK----WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLH 312
+P+ WT P + WK + + W+ IF +G D ++ + +L + P Q + +
Sbjct: 240 MPRSLSRWTSPKV--WKEHFEAWDCIFQYG----DNCIQKIYQELAFSRPQ--QYTSIVA 291
Query: 313 FLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAG 372
LL + +LSP + EL VDTT L L+ L+++P +Q+AL +E + +
Sbjct: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351
Query: 373 QVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVS 432
K +PLL+A LKETLRLYPV R+ ++ + + P T Y +
Sbjct: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLG 411
Query: 433 RDPTAFSEPESFQPHRWL--RNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLL 490
R+P F PE + P RWL R S F VPFG+G+R CLGRR+AE EM LLL
Sbjct: 412 RNPALFPRPERYNPQRWLDIRGS-------GRNFYHVPFGFGMRQCLGRRLAEAEMLLLL 464
Query: 491 ARLIQKYKVVLAPETGELKSVARIVLVPN 519
+++ +V + ++K V +L P+
Sbjct: 465 HHVLKHLQVETLTQE-DIKMVYSFILRPS 492
>gi|119829183 cytochrome P450, family 11, subfamily B, polypeptide 2
precursor [Homo sapiens]
Length = 503
Score = 187 bits (474), Expect = 3e-47
Identities = 143/516 (27%), Positives = 237/516 (45%), Gaps = 35/516 (6%)
Query: 26 RAKAAIPAALPSDKATGAPGAGPGVRRRQRSL---EEIPRLGQLRFFFQLFV---QGYA- 78
RAKA + A P A G R R++ E +P+ R+ L + QGY
Sbjct: 4 RAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEH 63
Query: 79 --LQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEH 136
L++HQ + GP++ LG V + +E++ + + +P R +E W +
Sbjct: 64 LHLEMHQTF----QELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAY 119
Query: 137 RDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAES 196
R G F G W R LN +L P + + V DF L + ++
Sbjct: 120 RQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQN 179
Query: 197 ASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATF 256
A G+ D+ +++ +EA LF +R+G + S ++ F+ ++ +MF++++ F
Sbjct: 180 ARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMF 239
Query: 257 LPK----WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLH 312
+P+ W P + WK + + W+ IF +G D ++ + +L P +G +
Sbjct: 240 MPRSLSRWISPKV--WKEHFEAWDCIFQYG----DNCIQKIYQELAFNRPQ--HYTGIVA 291
Query: 313 FLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAG 372
LL +LS + EL VDTT+ L L+ L+++P++Q+ L +E + +
Sbjct: 292 ELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASI 351
Query: 373 QVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVS 432
K +PLL+A LKETLRLYPV R++ ++ + + P T Y +
Sbjct: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLG 411
Query: 433 RDPTAFSEPESFQPHRWL--RNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLL 490
R+ F PE + P RWL R S F VPFG+G+R CLGRR+AE EM LLL
Sbjct: 412 RNAALFPRPERYNPQRWLDIRGS-------GRNFHHVPFGFGMRQCLGRRLAEAEMLLLL 464
Query: 491 ARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQF 526
+++ + V + ++K V +L P L F
Sbjct: 465 HHVLKHFLVETLTQE-DIKMVYSFILRPGTSPLLTF 499
>gi|153218654 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform b [Homo sapiens]
Length = 363
Score = 174 bits (440), Expect = 2e-43
Identities = 108/363 (29%), Positives = 184/363 (50%), Gaps = 12/363 (3%)
Query: 166 LKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKR 225
+ P + + V DF++ L + ++ SGN D++ + FA E+I ++F +R
Sbjct: 1 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 60
Query: 226 IGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVL--PFWKRYLDGWNAIFSFGK 283
G L+ + + F+ +I MF S+ LP + WK ++ W+ IFS
Sbjct: 61 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKA- 119
Query: 284 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNT 343
D ++ +L+ G G L+ LL ++S + ++ E+L GVDTTS T
Sbjct: 120 ---DIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT 176
Query: 344 LTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTN 403
L W LY ++++ ++Q+ L EV+ Q +PLLKA +KETLRL+P+ T
Sbjct: 177 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 236
Query: 404 SRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHP 463
R + ++ + ++ P T Y + R+PT F +PE+F P RWL + T
Sbjct: 237 QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNIT-----Y 291
Query: 464 FGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVG 523
F ++ FG+GVR CLGRRIAELEM + L +++ ++V + ++ + ++L+P K +
Sbjct: 292 FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI-QHLSDVGTTFNLILMPEKPIS 350
Query: 524 LQF 526
F
Sbjct: 351 FTF 353
>gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 437
Score = 141 bits (356), Expect = 1e-33
Identities = 109/407 (26%), Positives = 188/407 (46%), Gaps = 25/407 (6%)
Query: 26 RAKAAIPAALPSDKATGAPGAGPGVRRRQRSL---EEIPRLGQLRFFFQLFV---QGYA- 78
RAKA + A+P A G R R++ E +PR R+ L + QGY
Sbjct: 4 RAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYED 63
Query: 79 --LQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEH 136
L++HQ + GP++ LG V + +E++ + + +P R +E W +
Sbjct: 64 LHLEVHQTF----QELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY 119
Query: 137 RDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAES 196
R G F G W R LN +L P + + V DF L + ++
Sbjct: 120 RQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQN 179
Query: 197 ASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATF 256
A G+ D+ +++ +EA LF +R+G + S ++ F+ ++ +MF++++ F
Sbjct: 180 ARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMF 239
Query: 257 LPK----WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLH 312
+P+ WT P + WK + + W+ IF +G D ++ + +L + P Q + +
Sbjct: 240 MPRSLSRWTSPKV--WKEHFEAWDCIFQYG----DNCIQKIYQELAFSRPQ--QYTSIVA 291
Query: 313 FLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAG 372
LL + +LSP + EL VDTT L L+ L+++P +Q+AL +E + +
Sbjct: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351
Query: 373 QVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFP 419
K +PLL+A LKETLRLYPV R+ ++ + + P
Sbjct: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIP 398
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 132 bits (331), Expect = 1e-30
Identities = 114/467 (24%), Positives = 209/467 (44%), Gaps = 59/467 (12%)
Query: 91 KYGPMWMSYLGPQMHVNLASAPLLEQVM---RQEGKYPVRNDMELWKEHRDQHDLTYGPF 147
++ P+ ++GP V L +A +E ++ +Q K + +E W L G
Sbjct: 85 RHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPW--------LGLGLL 136
Query: 148 TTEGHHWYQLRQALNQRLLKPAEAALYTDAFN-EVIDDFMTRLDQ---LRAESASGNQVS 203
T+ G+ W R+ L T F+ +++DF+ +++ + + +
Sbjct: 137 TSTGNKWRSRRKML-------------TPTFHFTILEDFLDIMNEQANILVKKLEKHINQ 183
Query: 204 DMAQLFYYF---ALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKW 260
+ F+Y AL+ IC K IG D +VR++ M + +P W
Sbjct: 184 EAFNCFFYITLCALDIICETAMGKNIGAQSN----DDSEYVRAVYRMSEMIFRRIKMP-W 238
Query: 261 TRPVLPFWKRYLDGWN------AIFSFGKKLIDEKLEDMEAQLQAAG------PDGIQVS 308
L ++ + +GW + +F +I E+ +M A G P +
Sbjct: 239 LWLDL-WYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRR 297
Query: 309 GYLHFLLA-----SGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHE 363
+L LL+ +LS + + + G DTT+ + W+LY L +PE+Q+ +
Sbjct: 298 AFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDH 357
Query: 364 EVVGVVPAGQVPQH-KDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNT 422
E+ V P +D + L+ V+KETLRL+P VP +R + ++ EV G+ K T
Sbjct: 358 ELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGT 417
Query: 423 QFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIA 482
+ V Y + RDP F PE FQP R+ P + +HP+ VPF G R C+G++ A
Sbjct: 418 EAVIIPYALHRDPRYFPNPEEFQPERFF----PENAQGRHPYAYVPFSAGPRNCIGQKFA 473
Query: 483 ELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQR 529
+E + +L+ +++ + + + EL +++L P+ + ++ +R
Sbjct: 474 VMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 123 bits (308), Expect = 5e-28
Identities = 127/517 (24%), Positives = 215/517 (41%), Gaps = 80/517 (15%)
Query: 39 KATGAPGAGPGVRRRQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMS 98
K G PG P +P LG + + + F + ++ H+ KYG +W
Sbjct: 34 KKLGIPGPTP-----------LPFLGNILSYHKGFCM-FDMECHK-------KYGKVWGF 74
Query: 99 YLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPF--------TTE 150
Y G Q + + +++ V+ V+ ++ R +GP E
Sbjct: 75 YDGQQPVLAITDPDMIKTVL-------VKECYSVFTNRRP-----FGPVGFMKSAISIAE 122
Query: 151 GHHWYQLRQALNQRLL--KPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQL 208
W +LR L+ K E + +V+ + LR E+ +G V+ + +
Sbjct: 123 DEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVL------VRNLRREAETGKPVT-LKDV 175
Query: 209 FYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFW 268
F ++++ I F I L P+D FV + + + F T V PF
Sbjct: 176 FGAYSMDVITSTSFGVNIDSLNN--PQDP--FVENTKKLLRFDFLDPFFLSIT--VFPFL 229
Query: 269 KRYLDGWNA------IFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSP 322
L+ N + +F +K + E Q D +L ++ S
Sbjct: 230 IPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD------FLQLMIDSQNSKE 283
Query: 323 REAMGSLPEL---------LMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQ 373
E+ +L +L + AG +TTS+ L++ +Y L+ P++Q+ L EE+ V+P
Sbjct: 284 TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA 343
Query: 374 VPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSR 433
P + M L V+ ETLRL+P+ R+ +K++E++G PK + Y + R
Sbjct: 344 PPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHR 403
Query: 434 DPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARL 493
DP ++EPE F P R+ + ++ P+ PFG G R C+G R A + M+L L R+
Sbjct: 404 DPKYWTEPEKFLPERFSKKNKDNI----DPYIYTPFGSGPRNCIGMRFALMNMKLALIRV 459
Query: 494 IQKYKVVLAPETG-ELKSVARIVLVPNKKVGLQFLQR 529
+Q + ET LK +L P K V L+ R
Sbjct: 460 LQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 118 bits (296), Expect = 1e-26
Identities = 111/445 (24%), Positives = 190/445 (42%), Gaps = 29/445 (6%)
Query: 91 KYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTE 150
KYG MW Y G Q + + +++ V+ +E N M L + L++ E
Sbjct: 67 KYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFA----E 122
Query: 151 GHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFY 210
W ++R LL PA ++ +I L + + A ++ ++ F
Sbjct: 123 DEEWKRIRT-----LLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFG 177
Query: 211 YFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKR 270
+ ++ I LF + L P+D F++++ + + FL + + PF
Sbjct: 178 AYTMDVITGTLFGVNLDSLNN--PQDP--FLKNMKKLLKLDFLDPFLLLIS--LFPFLTP 231
Query: 271 YLDGWNA------IFSFGKKLIDEKLEDMEAQLQAAGPDGIQV---SGYLHFLLASGQLS 321
+ N + F K I+ E Q D Q S + LS
Sbjct: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALS 291
Query: 322 PREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFA 381
E + ++ A DTTS TL + +Y L+ P++Q+ L EE+ V+P +
Sbjct: 292 DLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALV 351
Query: 382 HMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEP 441
M L V+ ETLRL+PVV +R+ +K+IE++G PK + Y + DP ++EP
Sbjct: 352 QMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEP 411
Query: 442 ESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVL 501
E F P R+ + ++ + ++ +PFG G R C+G R A ++L + R +Q +
Sbjct: 412 EKFCPERFSKKNKDSIDLYRY----IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 467
Query: 502 APETG-ELKSVARIVLVPNKKVGLQ 525
ET LK +L P K + L+
Sbjct: 468 CKETQIPLKLDNLPILQPEKPIVLK 492
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 118 bits (295), Expect = 2e-26
Identities = 112/451 (24%), Positives = 196/451 (43%), Gaps = 42/451 (9%)
Query: 91 KYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTE 150
KYG MW +Y G + + ++ V+ +E N L + ++ E
Sbjct: 67 KYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA----E 122
Query: 151 GHHWYQLRQALNQRLL--KPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQL 208
W ++R L+ K E + +V+ + LR E+ G V+ + +
Sbjct: 123 DEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVL------VRNLRREAEKGKPVT-LKDI 175
Query: 209 FYYFALEAICYILFEKRIGCL---QRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVL 265
F ++++ I F I L Q E T F++ F + L+ + + +
Sbjct: 176 FGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK---FGFLDPLFLSII------LF 226
Query: 266 PFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVS-GYLHFLLASGQLSPRE 324
PF + N + F K I+ + + ++ D + +L ++ S E
Sbjct: 227 PFLTPVFEALN-VSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETE 285
Query: 325 AMGSLPEL---------LMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVP 375
+ +L +L + AG +TTS+ L++ LY L+ P++Q+ L +E+ V+P P
Sbjct: 286 SHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP 345
Query: 376 QHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDP 435
+ M L V+ ETLRL+PV R +K++E++G PK + V Y + DP
Sbjct: 346 TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDP 405
Query: 436 TAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQ 495
++EPE F+P R+ + P I PFG+ G R C+G R A + M+L L R++Q
Sbjct: 406 KYWTEPEEFRPERFSKKKDSIDPYIYTPFGT-----GPRNCIGMRFALMNMKLALIRVLQ 460
Query: 496 KYKVVLAPETG-ELKSVARIVLVPNKKVGLQ 525
+ ET LK + +L P K + L+
Sbjct: 461 NFSFKPCKETQIPLKLDTQGLLQPEKPIVLK 491
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 114 bits (284), Expect = 3e-25
Identities = 111/446 (24%), Positives = 190/446 (42%), Gaps = 30/446 (6%)
Query: 91 KYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTE 150
KYG MW Y G Q + + +++ V+ +E N M L + L++ E
Sbjct: 67 KYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFA----E 122
Query: 151 GHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFY 210
W ++R LL PA ++ +I L + + A ++ ++ F
Sbjct: 123 DEEWKRIRT-----LLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFG 177
Query: 211 YFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKR 270
+ ++ I LF + L P+D F++++ + + FL + + PF
Sbjct: 178 AYTMDVITGTLFGVNLDSLNN--PQDP--FLKNMKKLLKLDFLDPFLLLIS--LFPFLTP 231
Query: 271 YLDGWNA------IFSFGKKLIDEKLEDMEAQLQAAGPDGIQV---SGYLHFLLASGQLS 321
+ N + F K I+ E Q D Q S + LS
Sbjct: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALS 291
Query: 322 PREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFA 381
E + ++ A DTTS TL + +Y L+ P++Q+ L EE+ V+P +
Sbjct: 292 DLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALV 351
Query: 382 HMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEP 441
M L V+ ETLRL+PVV +R+ +K+IE++G PK + Y + DP ++EP
Sbjct: 352 QMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEP 411
Query: 442 ESFQPH-RWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVV 500
E F P R+ + ++ + ++ +PFG G R C+G R A ++L + R +Q +
Sbjct: 412 EKFCPESRFSKKNKDSIDLYRY----IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 467
Query: 501 LAPETG-ELKSVARIVLVPNKKVGLQ 525
ET LK +L P K + L+
Sbjct: 468 PCKETQIPLKLDNLPILQPEKPIVLK 493
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 113 bits (282), Expect = 5e-25
Identities = 60/186 (32%), Positives = 99/186 (53%), Gaps = 4/186 (2%)
Query: 320 LSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKD 379
LS E M + AG +TTS+ L++ +Y L+ P++Q+ + +E+ V+P P +
Sbjct: 290 LSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDT 349
Query: 380 FAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFS 439
+ L V+ ETLRL+PV R+ +K++E++G PK + YV+ DP ++
Sbjct: 350 VLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWT 409
Query: 440 EPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKV 499
EPE F P R+ + ++ P+ PFG G R C+G R A + M+L L R++Q +
Sbjct: 410 EPEKFLPERFSKKNKDNI----DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSF 465
Query: 500 VLAPET 505
ET
Sbjct: 466 KPCKET 471
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 111 bits (277), Expect = 2e-24
Identities = 94/378 (24%), Positives = 171/378 (45%), Gaps = 32/378 (8%)
Query: 153 HWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYF 212
H L A + +LKP Y FNE ++ + L +E G+ DM +
Sbjct: 147 HRRMLTPAFHFNILKP-----YMKIFNESVNIMHAKWQLLASE---GSACLDMFEHISLM 198
Query: 213 ALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLP-KWTRPVLPFWKRY 271
L+++ +F C ++ P + + + + + + L + + P +R+
Sbjct: 199 TLDSLQKCVFSFDSHCQEK--PSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRF 256
Query: 272 LDGWNAIFSFGKKLIDEKLEDMEAQ-----LQAAGPDGIQVSGYLHFLLASG-----QLS 321
+ F +I E+ + +Q LQA + ++ LL S +LS
Sbjct: 257 RRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKS--KTLDFIDVLLLSKDEDGKKLS 314
Query: 322 PREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHK--D 379
+ + G DTT++ L+W LYHL+K PE QE +EV ++ + + + D
Sbjct: 315 DEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDD 374
Query: 380 FAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV-DGFLFPKNTQFVFCHYVVSRDPTAF 438
AH+P L +KE+LRL+P VP SR + ++I + DG + PK + + +P +
Sbjct: 375 LAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW 434
Query: 439 SEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYK 498
+PE + P R+ P + + P +PF G R C+G+ A EM+++LA + +++
Sbjct: 435 PDPEVYDPFRF----DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFR 490
Query: 499 VVLAPETGELKSVARIVL 516
V+ P+ E + +VL
Sbjct: 491 VL--PDHTEPRRKPELVL 506
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 110 bits (274), Expect = 4e-24
Identities = 58/176 (32%), Positives = 97/176 (55%), Gaps = 5/176 (2%)
Query: 331 ELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVL 390
+L +AG DTT+N+L W L ++S +P++QE +HEE+ V+ A + P D A MP +A +
Sbjct: 348 DLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATI 407
Query: 391 KETLRLYPVVP-TNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRW 449
E RL VVP + + + G+ PK T + + V RDP + +PE F P+R+
Sbjct: 408 MEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRF 467
Query: 450 LRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPET 505
L + + +PFG G R C+G ++A++E+ L+ L+Q + L ++
Sbjct: 468 LDDQGQLIKKETF----IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDS 519
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 107 bits (267), Expect = 3e-23
Identities = 97/382 (25%), Positives = 170/382 (44%), Gaps = 40/382 (10%)
Query: 153 HWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYF 212
H L A + +LKP Y FNE ++ + L +E G+ DM +
Sbjct: 147 HRRMLTPAFHFNILKP-----YMKIFNESVNIMHAKWQLLASE---GSARLDMFEHISLM 198
Query: 213 ALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMF-----QNSLYATFLPKWTRPVLPF 267
L+++ +F C ++ P + + + + + Q LY FL T P
Sbjct: 199 TLDSLQKCVFSFDSHCQEK--PSEYIAAILELSALVTKRHQQILLYIDFLYYLT----PD 252
Query: 268 WKRYLDGWNAIFSFGKKLIDEKLEDMEAQ-----LQAAGPDGIQVSGYLHFLLASG---- 318
+R+ + F +I E+ + +Q LQA + ++ LL S
Sbjct: 253 GQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKS--KTLDFIDVLLLSKDEDG 310
Query: 319 -QLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQH 377
+LS + + G DTT++ L+W LYHL+K PE QE +EV ++ + +
Sbjct: 311 KKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEI 370
Query: 378 K--DFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV-DGFLFPKNTQFVFCHYVVSRD 434
+ D A +P L +KE+LRL+P VP SR ++I + DG + PK + + +
Sbjct: 371 EWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHN 430
Query: 435 PTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLI 494
P + +PE + P R+ P + + P +PF G R C+G+ A EM+++L +
Sbjct: 431 PAVWPDPEVYDPFRF----DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTL 486
Query: 495 QKYKVVLAPETGELKSVARIVL 516
+++V+ P+ E + +VL
Sbjct: 487 LRFRVL--PDHTEPRRKPELVL 506
>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
[Homo sapiens]
Length = 502
Score = 106 bits (264), Expect = 6e-23
Identities = 113/456 (24%), Positives = 180/456 (39%), Gaps = 32/456 (7%)
Query: 52 RRQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASA 111
+R+R P +L F F+ + Q H L+ KYG ++ LG V +
Sbjct: 36 KRRRPKNYPPGPWRLPFLGNFFLVDFE-QSHLEVQLFVKKYGNLFSLELGDISAVLITGL 94
Query: 112 PLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEA 171
PL+++ + + + +EH + + G + G W + R+ L
Sbjct: 95 PLIKEALIHMDQNFGNRPVTPMREHIFKKN---GLIMSSGQAWKEQRRFTLTAL---RNF 148
Query: 172 ALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQR 231
L + E I + L + E Q D IC I F +R
Sbjct: 149 GLGKKSLEERIQEEAQHLTEAIKEE--NGQPFDPHFKINNAVSNIICSITFGERFEYQDS 206
Query: 232 SIPE-----DTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYL-DGWNAIFSFGKKL 285
+ D VT++ + LY F W LP + L W + F +
Sbjct: 207 WFQQLLKLLDEVTYLEASKTC---QLYNVF--PWIMKFLPGPHQTLFSNWKKLKLFVSHM 261
Query: 286 IDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLT 345
ID+ +D D H + + S +L AG +TTS TL
Sbjct: 262 IDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLR 321
Query: 346 WALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSR 405
WAL +++ PEIQE + E+ V+ GQ P MP AV+ E R+ ++P N
Sbjct: 322 WALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLN-- 379
Query: 406 IIEKEIEVD----GFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQ 461
+ +E+ VD G+ PK T + + RDPT ++ P++F P +L N Q +
Sbjct: 380 -VPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQ-----FK 433
Query: 462 HPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKY 497
+PF G RACLG ++A E+ + L+QK+
Sbjct: 434 KREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
Length = 500
Score = 106 bits (264), Expect = 6e-23
Identities = 59/170 (34%), Positives = 98/170 (57%), Gaps = 6/170 (3%)
Query: 334 MAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKET 393
+AG +T++N L + + LS+ PEI L EV V+ + + +D + L VLKE+
Sbjct: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 360
Query: 394 LRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNS 453
LRLYP R++E+E +DG P NT +F YV+ R T F +P +F P R+
Sbjct: 361 LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF---- 416
Query: 454 QPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAP 503
P P+ + F PF G R+C+G++ A++E+++++A+L+Q+ + L P
Sbjct: 417 GPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP 464
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 105 bits (261), Expect = 1e-22
Identities = 92/383 (24%), Positives = 173/383 (45%), Gaps = 40/383 (10%)
Query: 152 HHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYY 211
HH L A + +LKP Y F++ + + +L E G+ D+ +
Sbjct: 146 HHRRLLTPAFHFNILKP-----YIKIFSKSANIMHAKWQRLAME---GSTCLDVFEHISL 197
Query: 212 FALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMF-----QNSLYATFLPKWTRPVLP 266
L+++ +F C ++ P + +T + + + Q Y FL T P
Sbjct: 198 MTLDSLQKCIFSFDSNCQEK--PSEYITAIMELSALVVKRNNQFFRYKDFLYFLT----P 251
Query: 267 FWKRYLDGWNAIFSFGKKLIDEKLEDMEAQ-----LQAAGPDGIQVSGYLHFLLASG--- 318
+R+ + F +I E+ + +Q LQA + ++ LL S
Sbjct: 252 CGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKS--KTLDFIDVLLLSEDKN 309
Query: 319 --QLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQ 376
+LS + + G DTT++ L+W LY+L++ PE QE +EV ++ + +
Sbjct: 310 GKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKE 369
Query: 377 HK--DFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV-DGFLFPKNTQFVFCHYVVSR 433
+ D A +P L LKE+LRL+P +PT +R +++ + D + PK + +
Sbjct: 370 IEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHH 429
Query: 434 DPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARL 493
+P+ + +PE + P R+ P + + P +PF G R C+G++ A EM+++LA
Sbjct: 430 NPSVWPDPEVYDPFRF----DPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALT 485
Query: 494 IQKYKVVLAPETGELKSVARIVL 516
+ +++++ P+ E + IVL
Sbjct: 486 LLRFRIL--PDHREPRRTPEIVL 506
>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform a [Homo sapiens]
Length = 495
Score = 101 bits (252), Expect = 1e-21
Identities = 107/432 (24%), Positives = 185/432 (42%), Gaps = 55/432 (12%)
Query: 91 KYGPMWMSYLGPQMHVNLASAPLLEQVM-RQEGKYPVRNDMELWK-EHRDQHDLTYGPFT 148
K+GP++ +LG Q V L S +E+ M ++ + R + +K R+ DL+ G
Sbjct: 55 KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGD-- 112
Query: 149 TEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQL 208
Y L +++L + A D+ V++ + R + G V+ + +
Sbjct: 113 ------YSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCE-RMRAQPGTPVA-IEEE 164
Query: 209 FYYFALEAICYILFEKRIG----------CLQRSIPEDTVTFVRSIGLMFQNSLYATFLP 258
F ICY+ F +I C+Q + + ++ + ++ FL
Sbjct: 165 FSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVI-------PFLR 217
Query: 259 KWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKL------EDMEAQLQAAGPDGIQVSGYLH 312
+ P L K+ ++ + I + E L + M+ LQ ++
Sbjct: 218 FFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEG---- 273
Query: 313 FLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEV---VGVV 369
SGQL + +LL+ G +TT+NTL+WA+ L PEIQ+ L EE+ +G
Sbjct: 274 ----SGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPG 329
Query: 370 PAGQVPQHKDFAHMPLLKAVLKETLRLYPVVP-TNSRIIEKEIEVDGFLFPKNTQFVFCH 428
+ +KD A +PLL A + E LRL PVVP + + G+ P+ T +
Sbjct: 330 ASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNL 389
Query: 429 YVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQL 488
D T + P F P R+L + + ++ FG G R CLG +A LE+ +
Sbjct: 390 QGAHLDETVWERPHEFWPDRFLEPGKNSR--------ALAFGCGARVCLGEPLARLELFV 441
Query: 489 LLARLIQKYKVV 500
+L RL+Q + ++
Sbjct: 442 VLTRLLQAFTLL 453
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 101 bits (252), Expect = 1e-21
Identities = 128/512 (25%), Positives = 208/512 (40%), Gaps = 72/512 (14%)
Query: 61 PRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQ 120
P +G L FF Q F + ++L +L YGP+ YLG +M + ++ +++QV+
Sbjct: 52 PFIGNLTFFRQGFWESQ-MELRKL-------YGPLCGYYLGRRMFIVISEPDMIKQVL-V 102
Query: 121 EGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNE 180
E N M E + D W ++R AL +A + NE
Sbjct: 103 ENFSNFTNRMASGLEFKSVADSV---LFLRDKRWEEVRGALM--------SAFSPEKLNE 151
Query: 181 VIDDFMTRLDQLRAES---ASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDT 237
++ D L A A D+ + + + + + + F + Q PED
Sbjct: 152 MVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQA--PEDP 209
Query: 238 VTFVRSIGLMFQNSLYATFL------PKWTRP---VLPFWKR-YLDGW------NAIFSF 281
FV+ F+ + L P P +LP R L+G+ N I
Sbjct: 210 --FVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALR 267
Query: 282 GKKLIDEKLEDMEAQL----QAAGPDGIQVSGYLHFLLASGQLSPR-------------- 323
++ +E+ D + +A P G+Q + + +S P
Sbjct: 268 DQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPL 327
Query: 324 ---EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDF 380
E +G L+AG + +NTL++A Y L+ +P+ QE L EV P+
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 381 AH-MPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFS 439
+P L V+ ETLR+YP +R ++ EV G P + DP +
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 440 EPESFQPHRWLRNSQPATPRIQH-PFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYK 498
PE+F P R+ A R QH PF +PFG G R+CLG R+ LE++L L ++ K++
Sbjct: 448 SPETFNPERFT-----AEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
Query: 499 VVLAPETG-ELKSVARIVLVPNKKVGLQFLQR 529
PET L+ ++ L P V ++ + R
Sbjct: 503 FQACPETQVPLQLESKSALGPKNGVYIKIVSR 534
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 101 bits (252), Expect = 1e-21
Identities = 128/512 (25%), Positives = 208/512 (40%), Gaps = 72/512 (14%)
Query: 61 PRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQ 120
P +G L FF Q F + ++L +L YGP+ YLG +M + ++ +++QV+
Sbjct: 52 PFIGNLTFFRQGFWESQ-MELRKL-------YGPLCGYYLGRRMFIVISEPDMIKQVL-V 102
Query: 121 EGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNE 180
E N M E + D W ++R AL +A + NE
Sbjct: 103 ENFSNFTNRMASGLEFKSVADSV---LFLRDKRWEEVRGALM--------SAFSPEKLNE 151
Query: 181 VIDDFMTRLDQLRAES---ASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDT 237
++ D L A A D+ + + + + + + F + Q PED
Sbjct: 152 MVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQA--PEDP 209
Query: 238 VTFVRSIGLMFQNSLYATFL------PKWTRP---VLPFWKR-YLDGW------NAIFSF 281
FV+ F+ + L P P +LP R L+G+ N I
Sbjct: 210 --FVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALR 267
Query: 282 GKKLIDEKLEDMEAQL----QAAGPDGIQVSGYLHFLLASGQLSPR-------------- 323
++ +E+ D + +A P G+Q + + +S P
Sbjct: 268 DQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPL 327
Query: 324 ---EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDF 380
E +G L+AG + +NTL++A Y L+ +P+ QE L EV P+
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 381 AH-MPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFS 439
+P L V+ ETLR+YP +R ++ EV G P + DP +
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 440 EPESFQPHRWLRNSQPATPRIQH-PFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYK 498
PE+F P R+ A R QH PF +PFG G R+CLG R+ LE++L L ++ K++
Sbjct: 448 SPETFNPERFT-----AEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
Query: 499 VVLAPETG-ELKSVARIVLVPNKKVGLQFLQR 529
PET L+ ++ L P V ++ + R
Sbjct: 503 FQACPETQVPLQLESKSALGPKNGVYIKIVSR 534
>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
[Homo sapiens]
Length = 490
Score = 99.4 bits (246), Expect = 7e-21
Identities = 68/228 (29%), Positives = 107/228 (46%), Gaps = 14/228 (6%)
Query: 286 IDEKLEDMEAQLQAAGPD---GIQVSGYLHFLLASGQ-------LSPREAMGSLPELLMA 335
I+E + L+A P G V Y+ L+ GQ + A+ +++MA
Sbjct: 237 IEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMA 296
Query: 336 GVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLR 395
G +TTS TL WA + + P++Q + EE+ V+ G+ P+ +D +P AVL E R
Sbjct: 297 GTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQR 356
Query: 396 LYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQP 455
++P R + ++ GFL PK T + V D T + P F P +L
Sbjct: 357 FITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFL----D 412
Query: 456 ATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAP 503
A +PF G R C+G R+A E+ LL A L+Q+Y+++ P
Sbjct: 413 ANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPP 460
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 97.4 bits (241), Expect = 3e-20
Identities = 88/368 (23%), Positives = 160/368 (43%), Gaps = 42/368 (11%)
Query: 153 HWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYF 212
H L A + +LKP Y FN+ ++ + +L +E G+ DM +
Sbjct: 147 HRRMLTPAFHFNILKP-----YMKIFNKSVNIMHDKWQRLASE---GSARLDMFEHISLM 198
Query: 213 ALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNS-----LYATFLPKWTRPVLPF 267
L+++ +F C ++ P + + + + + L+ FL T P
Sbjct: 199 TLDSLQKCVFSFESNCQEK--PSEYIAAILELSAFVEKRNQQILLHTDFLYYLT----PD 252
Query: 268 WKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGI-------QVSGYLHFLLASG-- 318
+R+ + + F +I E+ L G D + ++ LL S
Sbjct: 253 GQRFRRACHLVHDFTDAVIQER----RCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDE 308
Query: 319 ---QLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVP 375
+LS + + G DTT++ L+W LYHL+K PE QE +EV ++ +
Sbjct: 309 DGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPI 368
Query: 376 QHK--DFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV-DGFLFPKNTQFVFCHYVVS 432
+ + D A +P L +KE+LRL+P VP SR ++ + DG + PK + +
Sbjct: 369 EIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIH 428
Query: 433 RDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLAR 492
+PT + +PE + P R+ + + P +PF G R C+G+ A EM+++LA
Sbjct: 429 YNPTVWPDPEVYDPFRF----DQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLAL 484
Query: 493 LIQKYKVV 500
+ ++++
Sbjct: 485 TLLHFRIL 492
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 97.4 bits (241), Expect = 3e-20
Identities = 88/368 (23%), Positives = 160/368 (43%), Gaps = 42/368 (11%)
Query: 153 HWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYF 212
H L A + +LKP Y FN+ ++ + +L +E G+ DM +
Sbjct: 147 HRRMLTPAFHFNILKP-----YMKIFNKSVNIMHDKWQRLASE---GSARLDMFEHISLM 198
Query: 213 ALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNS-----LYATFLPKWTRPVLPF 267
L+++ +F C ++ P + + + + + L+ FL T P
Sbjct: 199 TLDSLQKCVFSFESNCQEK--PSEYIAAILELSAFVEKRNQQILLHTDFLYYLT----PD 252
Query: 268 WKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGI-------QVSGYLHFLLASG-- 318
+R+ + + F +I E+ L G D + ++ LL S
Sbjct: 253 GQRFRRACHLVHDFTDAVIQER----RCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDE 308
Query: 319 ---QLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVP 375
+LS + + G DTT++ L+W LYHL+K PE QE +EV ++ +
Sbjct: 309 DGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPI 368
Query: 376 QHK--DFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV-DGFLFPKNTQFVFCHYVVS 432
+ + D A +P L +KE+LRL+P VP SR ++ + DG + PK + +
Sbjct: 369 EIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIH 428
Query: 433 RDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLAR 492
+PT + +PE + P R+ + + P +PF G R C+G+ A EM+++LA
Sbjct: 429 YNPTVWPDPEVYDPFRF----DQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLAL 484
Query: 493 LIQKYKVV 500
+ ++++
Sbjct: 485 TLLHFRIL 492
>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
[Homo sapiens]
Length = 509
Score = 97.1 bits (240), Expect = 4e-20
Identities = 84/362 (23%), Positives = 156/362 (43%), Gaps = 17/362 (4%)
Query: 150 EGHHWYQLRQALNQRLLKPAEAALYTDAFNEVI-DDFMTRLDQLRAESASGNQVSDMAQL 208
+G W+Q R RLL P A+ EV+ LD+ ++ + ++ +
Sbjct: 129 DGPKWFQHR-----RLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEH 183
Query: 209 FYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYAT-FLPKWTRPVLPF 267
+L+ I F K C S + + + + + LY+ + + P
Sbjct: 184 INSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQ 243
Query: 268 WKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLAS-----GQLSP 322
R+ + + +I E+ + ++A ++ + +L +L++ S
Sbjct: 244 GYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSD 303
Query: 323 REAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAH 382
+ + L+AG DT + +++W LY L+ +PE QE EEV G++ G
Sbjct: 304 IDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGE 363
Query: 383 MPLLKAVLKETLRLYPVVPTNSRIIEKEIEV-DGFLFPKNTQFVFCHYVVSRDPTAFSEP 441
M +KET RL P VP+ SR + K + DG P V + + +P + P
Sbjct: 364 MSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNP 423
Query: 442 ESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVL 501
+ F P LR SQ + + +HP+ +PF G R C+G+ A +E+++ +A ++ ++V
Sbjct: 424 KVFDP---LRFSQENSDQ-RHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP 479
Query: 502 AP 503
P
Sbjct: 480 DP 481
>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform b [Homo sapiens]
Length = 465
Score = 95.9 bits (237), Expect = 8e-20
Identities = 62/188 (32%), Positives = 95/188 (50%), Gaps = 12/188 (6%)
Query: 317 SGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEV---VGVVPAGQ 373
SGQL + +LL+ G +TT+NTL+WA+ L PEIQ+ L EE+ +G +
Sbjct: 244 SGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSS 303
Query: 374 VPQHKDFAHMPLLKAVLKETLRLYPVVP-TNSRIIEKEIEVDGFLFPKNTQFVFCHYVVS 432
+KD A +PLL A + E LRL PVVP + + G+ P+ T +
Sbjct: 304 RVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAH 363
Query: 433 RDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLAR 492
D T + P F P R+L + + ++ FG G R CLG +A LE+ ++L R
Sbjct: 364 LDETVWERPHEFWPDRFLEPGKNSR--------ALAFGCGARVCLGEPLARLELFVVLTR 415
Query: 493 LIQKYKVV 500
L+Q + ++
Sbjct: 416 LLQAFTLL 423
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,816,966
Number of Sequences: 37866
Number of extensions: 956241
Number of successful extensions: 3085
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 2849
Number of HSP's gapped (non-prelim): 111
length of query: 531
length of database: 18,247,518
effective HSP length: 107
effective length of query: 424
effective length of database: 14,195,856
effective search space: 6019042944
effective search space used: 6019042944
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.