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Search of human proteins with 4503151
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503151 cathepsin K preproprotein [Homo sapiens]
(329 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503151 cathepsin K preproprotein [Homo sapiens] 689 0.0
gi|23110962 cathepsin S preproprotein [Homo sapiens] 369 e-102
gi|23110960 cathepsin L2 preproprotein [Homo sapiens] 333 1e-91
gi|22202619 cathepsin L1 preproprotein [Homo sapiens] 333 2e-91
gi|4503155 cathepsin L1 preproprotein [Homo sapiens] 333 2e-91
gi|23110957 cathepsin H isoform b precursor [Homo sapiens] 227 1e-59
gi|23110955 cathepsin H isoform a preproprotein [Homo sapiens] 227 1e-59
gi|6042196 cathepsin F [Homo sapiens] 166 3e-41
gi|4557501 cathepsin O preproprotein [Homo sapiens] 129 3e-30
gi|23110964 cathepsin W preproprotein [Homo sapiens] 125 4e-29
gi|189083844 cathepsin C isoform a preproprotein [Homo sapiens] 117 1e-26
gi|22538437 cathepsin B preproprotein [Homo sapiens] 94 1e-19
gi|22538435 cathepsin B preproprotein [Homo sapiens] 94 1e-19
gi|22538433 cathepsin B preproprotein [Homo sapiens] 94 1e-19
gi|22538431 cathepsin B preproprotein [Homo sapiens] 94 1e-19
gi|4503139 cathepsin B preproprotein [Homo sapiens] 94 1e-19
gi|22538442 cathepsin Z preproprotein [Homo sapiens] 91 2e-18
gi|224586907 tubulointerstitial nephritis antigen [Homo sapiens] 84 1e-16
gi|11545918 tubulointerstitial nephritis antigen-like 1 [Homo sa... 70 3e-12
gi|239744067 PREDICTED: similar to Putative cathepsin L-like pro... 60 2e-09
gi|4557367 bleomycin hydrolase [Homo sapiens] 33 0.35
gi|169189860 PREDICTED: similar to Cathepsin L1 [Homo sapiens] 29 6.6
gi|134288871 aminoglycoside phosphotransferase domain containing... 28 8.6
gi|37537684 zinc finger protein 92 isoform 1 [Homo sapiens] 28 8.6
gi|23097323 zinc finger protein 92 isoform 2 [Homo sapiens] 28 8.6
>gi|4503151 cathepsin K preproprotein [Homo sapiens]
Length = 329
Score = 689 bits (1778), Expect = 0.0
Identities = 329/329 (100%), Positives = 329/329 (100%)
Query: 1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH 60
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
Sbjct: 1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH 60
Query: 61 NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD 120
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
Sbjct: 61 NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD 120
Query: 121 YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG 180
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
Sbjct: 121 YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG 180
Query: 181 YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA 240
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
Sbjct: 181 YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA 240
Query: 241 RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE 300
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
Sbjct: 241 RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE 300
Query: 301 NWGNKGYILMARNKNNACGIANLASFPKM 329
NWGNKGYILMARNKNNACGIANLASFPKM
Sbjct: 301 NWGNKGYILMARNKNNACGIANLASFPKM 329
>gi|23110962 cathepsin S preproprotein [Homo sapiens]
Length = 331
Score = 369 bits (947), Expect = e-102
Identities = 178/317 (56%), Positives = 224/317 (70%), Gaps = 6/317 (1%)
Query: 16 LYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAM 75
L+ + LD HW LWKKT+ KQY K +E RRLIWEKNLK++ +HNLE S+G+H+Y+L M
Sbjct: 18 LHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGM 77
Query: 76 NHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQ 135
NHLGDMTSEEV+ M+ L+VP R + Y PDSVD+R+KG VT VK QG
Sbjct: 78 NHLGDMTSEEVMSLMSSLRVPSQWQR--NITYKSNPNRILPDSVDWREKGCVTEVKYQGS 135
Query: 136 CGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE---NDGCGGGYMTNAFQYVQKN 192
CG+CWAFS+VGALE QLK KTGKL++LS QNLVDC +E N GC GG+MT AFQY+ N
Sbjct: 136 CGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDN 195
Query: 193 RGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDAS 252
+GIDS+ +YPY ++ C Y+ +AA C Y E+P G E LK AVA GPVSV +DA
Sbjct: 196 KGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDAR 255
Query: 253 LTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMAR 312
SF Y GVYY+ SC + N+NH VL VGYG G ++W++KNSWG N+G +GYI MAR
Sbjct: 256 HPSFFLYRSGVYYEPSC-TQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMAR 314
Query: 313 NKNNACGIANLASFPKM 329
NK N CGIA+ S+P++
Sbjct: 315 NKGNHCGIASFPSYPEI 331
>gi|23110960 cathepsin L2 preproprotein [Homo sapiens]
Length = 334
Score = 333 bits (854), Expect = 1e-91
Identities = 164/319 (51%), Positives = 213/319 (66%), Gaps = 14/319 (4%)
Query: 19 EEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHL 78
++ LDT W WK THR+ Y +E RR +WEKN+K I +HN E S G H + +AMN
Sbjct: 22 DQNLDTKWYQWKATHRRLYGAN-EEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAF 80
Query: 79 GDMTSEEVVQKMTGLKVPLSHSRS--NDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQC 136
GDMT+EE Q M + + L++ P SVD+RKKGYVTPVKNQ QC
Sbjct: 81 GDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLD-----LPKSVDWRKKGYVTPVKNQKQC 135
Query: 137 GSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRG 194
GSCWAFS+ GALEGQ+ +KTGKL++LS QNLVDC N GC GG+M AFQYV++N G
Sbjct: 136 GSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGG 195
Query: 195 IDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLT 254
+DSE++YPYV +E C Y P A G+ + G EKAL +AVA VGP+SVA+DA +
Sbjct: 196 LDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHS 255
Query: 255 SFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGN----KHWIIKNSWGENWGNKGYILM 310
SFQFY G+Y++ C+S NL+H VL VGYG + N K+W++KNSWG WG+ GY+ +
Sbjct: 256 SFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKI 315
Query: 311 ARNKNNACGIANLASFPKM 329
A++KNN CGIA AS+P +
Sbjct: 316 AKDKNNHCGIATAASYPNV 334
>gi|22202619 cathepsin L1 preproprotein [Homo sapiens]
Length = 333
Score = 333 bits (853), Expect = 2e-91
Identities = 168/332 (50%), Positives = 218/332 (65%), Gaps = 15/332 (4%)
Query: 4 LKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLE 63
L L + S L + L+ W WK H + Y +E RR +WEKN+K I +HN E
Sbjct: 7 LAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMN-EEGWRRAVWEKNMKMIELHNQE 65
Query: 64 ASLGVHTYELAMNHLGDMTSEEVVQKMTGL--KVPLSHSRSNDTLYIPEWEGRAPDSVDY 121
G H++ +AMN GDMTSEE Q M G + P + L+ AP SVD+
Sbjct: 66 YREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFY-----EAPRSVDW 120
Query: 122 RKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGG 179
R+KGYVTPVKNQGQCGSCWAFS+ GALEGQ+ +KTG+L++LS QNLVDC N+GC G
Sbjct: 121 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG 180
Query: 180 GYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAV 239
G M AFQYVQ N G+DSE++YPY EESC YNP A G+ +IP+ EKAL +AV
Sbjct: 181 GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAV 239
Query: 240 ARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQK----GNKHWIIK 295
A VGP+SVAIDA SF FY +G+Y++ C+S++++H VL VGYG + NK+W++K
Sbjct: 240 ATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVK 299
Query: 296 NSWGENWGNKGYILMARNKNNACGIANLASFP 327
NSWGE WG GY+ MA+++ N CGIA+ AS+P
Sbjct: 300 NSWGEEWGMGGYVKMAKDRRNHCGIASAASYP 331
>gi|4503155 cathepsin L1 preproprotein [Homo sapiens]
Length = 333
Score = 333 bits (853), Expect = 2e-91
Identities = 168/332 (50%), Positives = 218/332 (65%), Gaps = 15/332 (4%)
Query: 4 LKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLE 63
L L + S L + L+ W WK H + Y +E RR +WEKN+K I +HN E
Sbjct: 7 LAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMN-EEGWRRAVWEKNMKMIELHNQE 65
Query: 64 ASLGVHTYELAMNHLGDMTSEEVVQKMTGL--KVPLSHSRSNDTLYIPEWEGRAPDSVDY 121
G H++ +AMN GDMTSEE Q M G + P + L+ AP SVD+
Sbjct: 66 YREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFY-----EAPRSVDW 120
Query: 122 RKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGG 179
R+KGYVTPVKNQGQCGSCWAFS+ GALEGQ+ +KTG+L++LS QNLVDC N+GC G
Sbjct: 121 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG 180
Query: 180 GYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAV 239
G M AFQYVQ N G+DSE++YPY EESC YNP A G+ +IP+ EKAL +AV
Sbjct: 181 GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAV 239
Query: 240 ARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQK----GNKHWIIK 295
A VGP+SVAIDA SF FY +G+Y++ C+S++++H VL VGYG + NK+W++K
Sbjct: 240 ATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVK 299
Query: 296 NSWGENWGNKGYILMARNKNNACGIANLASFP 327
NSWGE WG GY+ MA+++ N CGIA+ AS+P
Sbjct: 300 NSWGEEWGMGGYVKMAKDRRNHCGIASAASYP 331
>gi|23110957 cathepsin H isoform b precursor [Homo sapiens]
Length = 323
Score = 227 bits (579), Expect = 1e-59
Identities = 128/309 (41%), Positives = 176/309 (56%), Gaps = 17/309 (5%)
Query: 25 HWELWKKTHRKQYNNKVDEISRRL-IWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTS 83
H++ W HRK Y+ +E RL + N + I+ HN G HT+++A+N DM+
Sbjct: 22 HFKSWMSKHRKTYST--EEYHHRLQTFASNWRKINAHNN----GNHTFKMALNQFSDMSF 75
Query: 84 EEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKG-YVTPVKNQGQCGSCWAF 142
E+ K + + ++ L G P SVD+RKKG +V+PVKNQG CGSCW F
Sbjct: 76 AEIKHKYLWSEPQNCSATKSNYL---RGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTF 132
Query: 143 SSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDA 200
S+ GALE + TGK+L+L+ Q LVDC + N GC GG + AF+Y+ N+GI ED
Sbjct: 133 STTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDT 192
Query: 201 YPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYS 260
YPY G++ C + P + I +E+A+ AVA PVS A + + F Y
Sbjct: 193 YPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVT-QDFMMYR 251
Query: 261 KGVYYDESCNS--DNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNAC 318
G+Y SC+ D +NHAVLAVGYG + G +WI+KNSWG WG GY L+ R K N C
Sbjct: 252 TGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGK-NMC 310
Query: 319 GIANLASFP 327
G+A AS+P
Sbjct: 311 GLAACASYP 319
>gi|23110955 cathepsin H isoform a preproprotein [Homo sapiens]
Length = 335
Score = 227 bits (579), Expect = 1e-59
Identities = 128/309 (41%), Positives = 176/309 (56%), Gaps = 17/309 (5%)
Query: 25 HWELWKKTHRKQYNNKVDEISRRL-IWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTS 83
H++ W HRK Y+ +E RL + N + I+ HN G HT+++A+N DM+
Sbjct: 34 HFKSWMSKHRKTYST--EEYHHRLQTFASNWRKINAHNN----GNHTFKMALNQFSDMSF 87
Query: 84 EEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKG-YVTPVKNQGQCGSCWAF 142
E+ K + + ++ L G P SVD+RKKG +V+PVKNQG CGSCW F
Sbjct: 88 AEIKHKYLWSEPQNCSATKSNYL---RGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTF 144
Query: 143 SSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDA 200
S+ GALE + TGK+L+L+ Q LVDC + N GC GG + AF+Y+ N+GI ED
Sbjct: 145 STTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDT 204
Query: 201 YPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYS 260
YPY G++ C + P + I +E+A+ AVA PVS A + + F Y
Sbjct: 205 YPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVT-QDFMMYR 263
Query: 261 KGVYYDESCNS--DNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNAC 318
G+Y SC+ D +NHAVLAVGYG + G +WI+KNSWG WG GY L+ R K N C
Sbjct: 264 TGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGK-NMC 322
Query: 319 GIANLASFP 327
G+A AS+P
Sbjct: 323 GLAACASYP 331
>gi|6042196 cathepsin F [Homo sapiens]
Length = 484
Score = 166 bits (419), Expect = 3e-41
Identities = 107/304 (35%), Positives = 159/304 (52%), Gaps = 27/304 (8%)
Query: 32 THRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEE------ 85
T+ + Y +K + R ++ N+ + ++A L T + + D+T EE
Sbjct: 193 TYNRTYESKEEARWRLSVFVNNM--VRAQKIQA-LDRGTAQYGVTKFSDLTEEEFRTIYL 249
Query: 86 --VVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFS 143
+++K G K + ++S L PEW D+R KG VT VK+QG CGSCWAFS
Sbjct: 250 NTLLRKEPGNK--MKQAKSVGDLAPPEW--------DWRSKGAVTKVKDQGMCGSCWAFS 299
Query: 144 SVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPY 203
G +EGQ G LL+LS Q L+DC + C GG +NA+ ++ G+++ED Y Y
Sbjct: 300 VTGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSY 359
Query: 204 VGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGV 263
G +SC ++ E+ + NE+ L +A+ GP+SVAI+A QFY G+
Sbjct: 360 QGHMQSCNFSAEKAKVYINDSVELSQ-NEQKLAAWLAKRGPISVAINA--FGMQFYRHGI 416
Query: 264 Y--YDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIA 321
C+ ++HAVL VGYG + W IKNSWG +WG KGY + R + ACG+
Sbjct: 417 SRPLRPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRG-SGACGVN 475
Query: 322 NLAS 325
+AS
Sbjct: 476 TMAS 479
>gi|4557501 cathepsin O preproprotein [Homo sapiens]
Length = 321
Score = 129 bits (325), Expect = 3e-30
Identities = 77/213 (36%), Positives = 108/213 (50%), Gaps = 7/213 (3%)
Query: 116 PDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSEND 175
P D+R K VT V+NQ CG CWAFS VGA+E K L +LS Q ++DC N
Sbjct: 109 PLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNY 168
Query: 176 GCGGGYMTNAFQYVQKNR-GIDSEDAYPYVGQEESCMY-NPTGKAAKCRGYREIP-EGNE 232
GC GG NA ++ K + + + YP+ Q C Y + + +GY E
Sbjct: 169 GCNGGSTLNALNWLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQE 228
Query: 233 KALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHW 292
+ +A+ GP+ V +DA S+Q Y G+ C+S NHAVL G+ +W
Sbjct: 229 DEMAKALLTFGPLVVIVDA--VSWQDYLGGI-IQHHCSSGEANHAVLITGFDKTGSTPYW 285
Query: 293 IIKNSWGENWGNKGYILMARNKNNACGIANLAS 325
I++NSWG +WG GY + +N CGIA+ S
Sbjct: 286 IVRNSWGSSWGVDGY-AHVKMGSNVCGIADSVS 317
>gi|23110964 cathepsin W preproprotein [Homo sapiens]
Length = 376
Score = 125 bits (315), Expect = 4e-29
Identities = 91/296 (30%), Positives = 138/296 (46%), Gaps = 38/296 (12%)
Query: 57 ISIHNL-------EASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIP 109
I HNL E LG T E + D+T EE Q + +
Sbjct: 65 IFAHNLAQAQRLQEEDLG--TAEFGVTPFSDLTEEEFGQLYGYRRAAGGVPSMGREIRSE 122
Query: 110 EWEGRAPDSVDYRK-KGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLV 168
E E P S D+RK G ++P+K+Q C CWA ++ G +E + +++S Q L+
Sbjct: 123 EPEESVPFSCDWRKVAGAISPIKDQKNCNCCWAMAAAGNIETLWRISFWDFVDVSVQELL 182
Query: 169 DCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYRE-- 226
DC DGC GG++ +AF V N G+ SE YP+ G+ + +P K K ++
Sbjct: 183 DCGRCGDGCHGGFVWDAFITVLNNSGLASEKDYPFQGKVRAHRCHPK-KYQKVAWIQDFI 241
Query: 227 IPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVY--YDESCNSDNLNHAVLAVGYG 284
+ + NE + + +A GP++V I ++ Q Y KGV +C+ ++H+VL VG+G
Sbjct: 242 MLQNNEHRIAQYLATYGPITVTI--NMKPLQLYRKGVIKATPTTCDPQLVDHSVLLVGFG 299
Query: 285 IQKGNK--------------------HWIIKNSWGENWGNKGYILMARNKNNACGI 320
K + +WI+KNSWG WG KGY + R +N CGI
Sbjct: 300 SVKSEEGIWAETVSSQSQPQPPHPTPYWILKNSWGAQWGEKGYFRLHRG-SNTCGI 354
>gi|189083844 cathepsin C isoform a preproprotein [Homo sapiens]
Length = 463
Score = 117 bits (293), Expect = 1e-26
Identities = 91/304 (29%), Positives = 138/304 (45%), Gaps = 25/304 (8%)
Query: 39 NKVDEISRRLIWEKNLKYISIHNLEASLGVHTY-ELAMNHLGDMT--SEEVVQKMTGLK- 94
N ++ S RL + +I+ ++ S TY E LGDM S +K+ K
Sbjct: 158 NSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKP 217
Query: 95 VPLSHSRSNDTLYIP-EWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLK 153
PL+ L++P W+ R +++ V+PV+NQ CGSC++F+S+G LE +++
Sbjct: 218 APLTAEIQQKILHLPTSWDWRNVHGINF-----VSPVRNQASCGSCYSFASMGMLEARIR 272
Query: 154 KKTGKLLN--LSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCM 211
T LSPQ +V C GC GG+ ++ G+ E +PY G + C
Sbjct: 273 ILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCK 332
Query: 212 YNPTGKAAKCRGYREI----PEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDE 267
Y + NE +K + GP++VA + F Y KG+Y+
Sbjct: 333 MKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEV-YDDFLHYKKGIYHHT 391
Query: 268 SCNS-----DNLNHAVLAVGYGIQ--KGNKHWIIKNSWGENWGNKGYILMARNKNNACGI 320
+ NHAVL VGYG G +WI+KNSWG WG GY + R + C I
Sbjct: 392 GLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRG-TDECAI 450
Query: 321 ANLA 324
++A
Sbjct: 451 ESIA 454
>gi|22538437 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 94.4 bits (233), Expect = 1e-19
Identities = 71/257 (27%), Positives = 115/257 (44%), Gaps = 46/257 (17%)
Query: 114 RAPDSVDYRKKGYVTP----VKNQGQCGSCWAFSSVGALEGQLKKKTGK--LLNLSPQNL 167
+ P S D R++ P +++QG CGSCWAF +V A+ ++ T + +S ++L
Sbjct: 79 KLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDL 138
Query: 168 VDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDAY-------PYV---------GQEES 209
+ C DGC GGY A+ + + +G+ S Y PY G
Sbjct: 139 LTCCGSMCGDGCNGGYPAEAWNFWTR-KGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPP 197
Query: 210 CM---------------YNPTGKAAKCRGYREIPEGN-EKALKRAVARVGPVSVAIDASL 253
C Y+PT K K GY N EK + + + GPV A
Sbjct: 198 CTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSV-Y 256
Query: 254 TSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARN 313
+ F Y GVY + HA+ +G+G++ G +W++ NSW +WG+ G+ + R
Sbjct: 257 SDFLLYKSGVYQHVTGEMMG-GHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRG 315
Query: 314 KNNACGIAN--LASFPK 328
+++ CGI + +A P+
Sbjct: 316 QDH-CGIESEVVAGIPR 331
>gi|22538435 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 94.4 bits (233), Expect = 1e-19
Identities = 71/257 (27%), Positives = 115/257 (44%), Gaps = 46/257 (17%)
Query: 114 RAPDSVDYRKKGYVTP----VKNQGQCGSCWAFSSVGALEGQLKKKTGK--LLNLSPQNL 167
+ P S D R++ P +++QG CGSCWAF +V A+ ++ T + +S ++L
Sbjct: 79 KLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDL 138
Query: 168 VDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDAY-------PYV---------GQEES 209
+ C DGC GGY A+ + + +G+ S Y PY G
Sbjct: 139 LTCCGSMCGDGCNGGYPAEAWNFWTR-KGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPP 197
Query: 210 CM---------------YNPTGKAAKCRGYREIPEGN-EKALKRAVARVGPVSVAIDASL 253
C Y+PT K K GY N EK + + + GPV A
Sbjct: 198 CTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSV-Y 256
Query: 254 TSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARN 313
+ F Y GVY + HA+ +G+G++ G +W++ NSW +WG+ G+ + R
Sbjct: 257 SDFLLYKSGVYQHVTGEMMG-GHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRG 315
Query: 314 KNNACGIAN--LASFPK 328
+++ CGI + +A P+
Sbjct: 316 QDH-CGIESEVVAGIPR 331
>gi|22538433 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 94.4 bits (233), Expect = 1e-19
Identities = 71/257 (27%), Positives = 115/257 (44%), Gaps = 46/257 (17%)
Query: 114 RAPDSVDYRKKGYVTP----VKNQGQCGSCWAFSSVGALEGQLKKKTGK--LLNLSPQNL 167
+ P S D R++ P +++QG CGSCWAF +V A+ ++ T + +S ++L
Sbjct: 79 KLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDL 138
Query: 168 VDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDAY-------PYV---------GQEES 209
+ C DGC GGY A+ + + +G+ S Y PY G
Sbjct: 139 LTCCGSMCGDGCNGGYPAEAWNFWTR-KGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPP 197
Query: 210 CM---------------YNPTGKAAKCRGYREIPEGN-EKALKRAVARVGPVSVAIDASL 253
C Y+PT K K GY N EK + + + GPV A
Sbjct: 198 CTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSV-Y 256
Query: 254 TSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARN 313
+ F Y GVY + HA+ +G+G++ G +W++ NSW +WG+ G+ + R
Sbjct: 257 SDFLLYKSGVYQHVTGEMMG-GHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRG 315
Query: 314 KNNACGIAN--LASFPK 328
+++ CGI + +A P+
Sbjct: 316 QDH-CGIESEVVAGIPR 331
>gi|22538431 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 94.4 bits (233), Expect = 1e-19
Identities = 71/257 (27%), Positives = 115/257 (44%), Gaps = 46/257 (17%)
Query: 114 RAPDSVDYRKKGYVTP----VKNQGQCGSCWAFSSVGALEGQLKKKTGK--LLNLSPQNL 167
+ P S D R++ P +++QG CGSCWAF +V A+ ++ T + +S ++L
Sbjct: 79 KLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDL 138
Query: 168 VDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDAY-------PYV---------GQEES 209
+ C DGC GGY A+ + + +G+ S Y PY G
Sbjct: 139 LTCCGSMCGDGCNGGYPAEAWNFWTR-KGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPP 197
Query: 210 CM---------------YNPTGKAAKCRGYREIPEGN-EKALKRAVARVGPVSVAIDASL 253
C Y+PT K K GY N EK + + + GPV A
Sbjct: 198 CTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSV-Y 256
Query: 254 TSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARN 313
+ F Y GVY + HA+ +G+G++ G +W++ NSW +WG+ G+ + R
Sbjct: 257 SDFLLYKSGVYQHVTGEMMG-GHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRG 315
Query: 314 KNNACGIAN--LASFPK 328
+++ CGI + +A P+
Sbjct: 316 QDH-CGIESEVVAGIPR 331
>gi|4503139 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 94.4 bits (233), Expect = 1e-19
Identities = 71/257 (27%), Positives = 115/257 (44%), Gaps = 46/257 (17%)
Query: 114 RAPDSVDYRKKGYVTP----VKNQGQCGSCWAFSSVGALEGQLKKKTGK--LLNLSPQNL 167
+ P S D R++ P +++QG CGSCWAF +V A+ ++ T + +S ++L
Sbjct: 79 KLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDL 138
Query: 168 VDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDAY-------PYV---------GQEES 209
+ C DGC GGY A+ + + +G+ S Y PY G
Sbjct: 139 LTCCGSMCGDGCNGGYPAEAWNFWTR-KGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPP 197
Query: 210 CM---------------YNPTGKAAKCRGYREIPEGN-EKALKRAVARVGPVSVAIDASL 253
C Y+PT K K GY N EK + + + GPV A
Sbjct: 198 CTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSV-Y 256
Query: 254 TSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARN 313
+ F Y GVY + HA+ +G+G++ G +W++ NSW +WG+ G+ + R
Sbjct: 257 SDFLLYKSGVYQHVTGEMMG-GHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRG 315
Query: 314 KNNACGIAN--LASFPK 328
+++ CGI + +A P+
Sbjct: 316 QDH-CGIESEVVAGIPR 331
>gi|22538442 cathepsin Z preproprotein [Homo sapiens]
Length = 303
Score = 90.5 bits (223), Expect = 2e-18
Identities = 65/216 (30%), Positives = 105/216 (48%), Gaps = 26/216 (12%)
Query: 111 WEGRAPDSVDYRKKGYVTPVKNQGQ-CGSCWAFSSVGALEGQLK-KKTGKLLN--LSPQN 166
W+ R D V+Y +T ++ Q CGSCWA +S A+ ++ K+ G + LS QN
Sbjct: 66 WDWRNVDGVNYAS---ITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQN 122
Query: 167 LVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESC-MYNPTGKA---AKCR 222
++DC + C GG + + Y ++ GI E Y +++ C +N G +C
Sbjct: 123 VIDCGNAGS-CEGGNDLSVWDYAHQH-GIPDETCNNYQAKDQECDKFNQCGTCNEFKECH 180
Query: 223 GYREIP----------EGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSD 272
R G EK + A GP+S I A+ Y+ G+Y + ++
Sbjct: 181 AIRNYTLWRVGDYGSLSGREKMMAEIYAN-GPISCGIMAT-ERLANYTGGIYAEYQ-DTT 237
Query: 273 NLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYI 308
+NH V G+GI G ++WI++NSWGE WG +G++
Sbjct: 238 YINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWL 273
>gi|224586907 tubulointerstitial nephritis antigen [Homo sapiens]
Length = 476
Score = 84.3 bits (207), Expect = 1e-16
Identities = 69/236 (29%), Positives = 104/236 (44%), Gaps = 42/236 (17%)
Query: 121 YRKKGYVTPVKNQGQCGSCWAFS--SVGALEGQLKKKTGKLLNLSPQNLVDCVSEN-DGC 177
Y+ G+ +Q C + WAFS SV A ++ K NLSPQNL+ C ++N GC
Sbjct: 225 YKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGC 284
Query: 178 GGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRG-------------- 223
G + A+ Y++K RG+ S YP ++++ N A++ G
Sbjct: 285 NSGSIDRAWWYLRK-RGLVSHACYPLF-KDQNATNNGCAMASRSDGRGKRHATKPCPNNV 342
Query: 224 ------YREIP----EGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVY-YDESCNSD 272
Y+ P NE + + + + GPV AI F Y G+Y + S N +
Sbjct: 343 EKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQ-AIMQVREDFFHYKTGIYRHVTSTNKE 401
Query: 273 N------LNHAVLAVGYGIQKG-----NKHWIIKNSWGENWGNKGYILMARNKNNA 317
+ HAV G+G +G K WI NSWG++WG GY + R N +
Sbjct: 402 SEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNES 457
>gi|11545918 tubulointerstitial nephritis antigen-like 1 [Homo
sapiens]
Length = 467
Score = 69.7 bits (169), Expect = 3e-12
Identities = 59/225 (26%), Positives = 94/225 (41%), Gaps = 43/225 (19%)
Query: 132 NQGQCGSCWAFSSVGALEGQLK-KKTGKLLN-LSPQNLVDC-VSENDGCGGGYMTNAFQY 188
+QG C WAFS+ ++ G + LSPQNL+ C + GC GG + A+ +
Sbjct: 222 DQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWF 281
Query: 189 VQKNRGIDSEDAYPYVGQEES-------CMYNPT----GK---AAKCRG--------YRE 226
+++ RG+ S+ YP+ G+E CM + GK A C Y+
Sbjct: 282 LRR-RGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQV 340
Query: 227 IPE----GNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLN------- 275
P N+K + + + GPV ++ F Y G+Y +
Sbjct: 341 TPVYRLGSNDKEIMKELMENGPVQALMEVH-EDFFLYKGGIYSHTPVSLGRPERYRRHGT 399
Query: 276 HAVLAVGYGIQ-----KGNKHWIIKNSWGENWGNKGYILMARNKN 315
H+V G+G + + K+W NSWG WG +G+ + R N
Sbjct: 400 HSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVN 444
>gi|239744067 PREDICTED: similar to Putative cathepsin L-like
protein 6 [Homo sapiens]
Length = 81
Score = 60.5 bits (145), Expect = 2e-09
Identities = 34/80 (42%), Positives = 44/80 (55%), Gaps = 3/80 (3%)
Query: 54 LKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEG 113
+K HN E S G H++ +AMN GDMT+EE Q M G + N +
Sbjct: 1 MKMTEQHNQEYSQGKHSFTMAMNTFGDMTTEEFRQVMNGFQY---QKHRNGKQFQERLLL 57
Query: 114 RAPDSVDYRKKGYVTPVKNQ 133
P SVD+R+KGYVTPVK+Q
Sbjct: 58 EIPTSVDWREKGYVTPVKDQ 77
>gi|4557367 bleomycin hydrolase [Homo sapiens]
Length = 455
Score = 33.1 bits (74), Expect = 0.35
Identities = 11/19 (57%), Positives = 16/19 (84%)
Query: 292 WIIKNSWGENWGNKGYILM 310
W ++NSWGE+ G+KGY+ M
Sbjct: 392 WRVENSWGEDHGHKGYLCM 410
>gi|169189860 PREDICTED: similar to Cathepsin L1 [Homo sapiens]
Length = 51
Score = 28.9 bits (63), Expect = 6.6
Identities = 12/34 (35%), Positives = 16/34 (47%)
Query: 4 LKVLLLPVVSFALYPEEILDTHWELWKKTHRKQY 37
L L + S AL + LD W WK H++ Y
Sbjct: 7 LAAFFLGIASAALTRDHSLDAQWTKWKAKHKRLY 40
>gi|134288871 aminoglycoside phosphotransferase domain containing 1
isoform 1 [Homo sapiens]
Length = 373
Score = 28.5 bits (62), Expect = 8.6
Identities = 23/97 (23%), Positives = 46/97 (47%), Gaps = 4/97 (4%)
Query: 31 KTHRKQYNNKVDEISRR-LIWEKNLKYISI-HNLEASLGVHTYELAMNHLGDMTSEEVVQ 88
KT ++ ++ K+ + R IW NLK + + +LG + + H+ + EEV+
Sbjct: 156 KTLQRFHHPKLSSLHRENFIW--NLKNVPLLEKYLYALGQNRNREIVEHVIHLFKEEVMT 213
Query: 89 KMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKG 125
K++ + ++H ND + E A + +Y+ G
Sbjct: 214 KLSHFRECINHGDLNDHNILIESSKSASGNAEYQVSG 250
>gi|37537684 zinc finger protein 92 isoform 1 [Homo sapiens]
Length = 517
Score = 28.5 bits (62), Expect = 8.6
Identities = 15/59 (25%), Positives = 26/59 (44%), Gaps = 1/59 (1%)
Query: 30 KKTHRKQYNNKVDEISRRLIWEKNL-KYISIHNLEASLGVHTYELAMNHLGDMTSEEVV 87
KK H ++Y+ K +E + W L K+ IH E A N ++T +++
Sbjct: 123 KKIHTREYSYKCEECGKAFNWSSTLTKHKIIHTGEKPYKCEECGKAFNRSSNLTKHKII 181
>gi|23097323 zinc finger protein 92 isoform 2 [Homo sapiens]
Length = 586
Score = 28.5 bits (62), Expect = 8.6
Identities = 15/59 (25%), Positives = 26/59 (44%), Gaps = 1/59 (1%)
Query: 30 KKTHRKQYNNKVDEISRRLIWEKNL-KYISIHNLEASLGVHTYELAMNHLGDMTSEEVV 87
KK H ++Y+ K +E + W L K+ IH E A N ++T +++
Sbjct: 192 KKIHTREYSYKCEECGKAFNWSSTLTKHKIIHTGEKPYKCEECGKAFNRSSNLTKHKII 250
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,035,986
Number of Sequences: 37866
Number of extensions: 583185
Number of successful extensions: 1236
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1158
Number of HSP's gapped (non-prelim): 32
length of query: 329
length of database: 18,247,518
effective HSP length: 103
effective length of query: 226
effective length of database: 14,347,320
effective search space: 3242494320
effective search space used: 3242494320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.