Search of human proteins with 4503149

Search of human proteins with 4503149

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503149 cathepsin G preproprotein [Homo sapiens]
         (255 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503149 cathepsin G preproprotein [Homo sapiens]                   520   e-148
gi|221625528 granzyme B precursor [Homo sapiens]                      293   8e-80
gi|15529990 granzyme H [Homo sapiens]                                 289   2e-78
gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens]          248   4e-66
gi|71361688 myeloblastin [Homo sapiens]                               159   2e-39
gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprot...   152   3e-37
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]           151   5e-37
gi|42544239 complement factor D preproprotein [Homo sapiens]          149   3e-36
gi|91823048 kallikrein 14 preproprotein [Homo sapiens]                147   7e-36
gi|5453676 granzyme A precursor [Homo sapiens]                        147   1e-35
gi|4504235 granzyme K precursor [Homo sapiens]                        144   6e-35
gi|11496281 kallikrein 13 precursor [Homo sapiens]                    142   2e-34
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]           140   8e-34
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]        140   1e-33
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]       140   1e-33
gi|4885369 granzyme M precursor [Homo sapiens]                        139   3e-33
gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo s...   138   4e-33
gi|61744424 kallikrein-related peptidase 6 isoform A preproprote...   137   7e-33
gi|4506155 kallikrein-related peptidase 6 isoform A preproprotei...   137   7e-33
gi|4503549 neutrophil elastase preproprotein [Homo sapiens]           137   7e-33
gi|47551347 protease, serine-like 1 [Homo sapiens]                    137   9e-33
gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens]        136   2e-32
gi|21464127 kallikrein 8 isoform 2 [Homo sapiens]                     135   3e-32
gi|21327705 stratum corneum chymotryptic enzyme preproprotein [H...   133   2e-31
gi|4826950 stratum corneum chymotryptic enzyme preproprotein [Ho...   133   2e-31
gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]     129   2e-30
gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]          129   2e-30
gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]       129   2e-30
gi|110815798 ovochymase 1 [Homo sapiens]                              125   4e-29
gi|5031829 kallikrein 2, prostatic isoform 1 [Homo sapiens]           123   1e-28

>gi|4503149 cathepsin G preproprotein [Homo sapiens]
          Length = 255

 Score =  520 bits (1338), Expect = e-148
 Identities = 255/255 (100%), Positives = 255/255 (100%)

Query: 1   MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL 60
           MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
Sbjct: 1   MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL 60

Query: 61  TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR 120
           TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
Sbjct: 61  TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR 120

Query: 121 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD 180
           NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD
Sbjct: 121 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD 180

Query: 181 PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT 240
           PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT
Sbjct: 181 PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT 240

Query: 241 TMRSFKLLDQMETPL 255
           TMRSFKLLDQMETPL
Sbjct: 241 TMRSFKLLDQMETPL 255


>gi|221625528 granzyme B precursor [Homo sapiens]
          Length = 247

 Score =  293 bits (751), Expect = 8e-80
 Identities = 143/249 (57%), Positives = 185/249 (74%), Gaps = 6/249 (2%)

Query: 1   MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL 60
           MQP+LLLLAFLL   A+AGEIIGG E++PHSRPYMAYL I       RCGGFL+R+DFVL
Sbjct: 1   MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL 60

Query: 61  TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR 120
           TAAHCWGS+INVTLGAHNI+ +E TQQ I  +R I HP YN +   NDIMLLQL R+ +R
Sbjct: 61  TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR 120

Query: 121 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQC---LRIF 176
            R V P+ LP  +  ++PG  C+VAGWG+ + + + + TL+EV++ VQ DR+C   LR +
Sbjct: 121 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY 180

Query: 177 GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLP 236
             YD   ++CVGD   +K +FKGDSGGPL+CN VA GIVSYG+++G+PP   T+VSSF+ 
Sbjct: 181 --YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVH 238

Query: 237 WIRTTMRSF 245
           WI+ TM+ +
Sbjct: 239 WIKKTMKRY 247


>gi|15529990 granzyme H [Homo sapiens]
          Length = 246

 Score =  289 bits (739), Expect = 2e-78
 Identities = 141/244 (57%), Positives = 175/244 (71%), Gaps = 1/244 (0%)

Query: 1   MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL 60
           MQP LLLLAFLL  GA   EIIGG E++PHSRPYMA++Q      + RCGG LVR+DFVL
Sbjct: 1   MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL 60

Query: 61  TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR 120
           TAAHC GS+INVTLGAHNI+ +E TQQ I  +R I HP YN +   NDIMLLQL R+ + 
Sbjct: 61  TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW 120

Query: 121 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIF-GSY 179
              V P+ LP ++  ++PG LC+VAGWG VSM     TL+EV L VQ+D QC R+F G+Y
Sbjct: 121 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY 180

Query: 180 DPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIR 239
               +ICVGD ++ +  FKGDSGGPL+C +VA GI+SYG   G PP V+ +VS FLPWI+
Sbjct: 181 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK 240

Query: 240 TTMR 243
            TM+
Sbjct: 241 RTMK 244


>gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens]
          Length = 247

 Score =  248 bits (633), Expect = 4e-66
 Identities = 128/242 (52%), Positives = 164/242 (67%), Gaps = 3/242 (1%)

Query: 5   LLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSR-CGGFLVREDFVLTAA 63
           L LL FLL + AEAGEIIGG E +PHSRPYMAYL+I +  G S+ CGGFL+R +FVLTAA
Sbjct: 6   LPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAA 65

Query: 64  HCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRN 123
           HC G +I VTLGAHNI   E+T Q +   +  RHP+YN  T+ +DIMLL+L  +      
Sbjct: 66  HCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLA 125

Query: 124 VNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQCLRIFGSYDPR 182
           V  +  P     + PG +C VAGWGR   ++ G+DTL+EV+LR+  D Q    F  +D  
Sbjct: 126 VGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLM-DPQACSHFRDFDHN 184

Query: 183 RQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTM 242
            Q+CVG+ R+ K+AFKGDSGGPLLC  VA GIVSYG+S   PP VFTR+S + PWI   +
Sbjct: 185 LQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQIL 244

Query: 243 RS 244
           ++
Sbjct: 245 QA 246


>gi|71361688 myeloblastin [Homo sapiens]
          Length = 256

 Score =  159 bits (402), Expect = 2e-39
 Identities = 94/246 (38%), Positives = 135/246 (54%), Gaps = 18/246 (7%)

Query: 6   LLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHC 65
           +LLA LL   A A EI+GG E++PHSRPYMA LQ++   G   CGG L+   FVLTAAHC
Sbjct: 13  VLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHC 72

Query: 66  WGS----NINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRN 121
                   +NV LGAHN++ +E TQQH +  +   +  Y+     ND++L+QLS     +
Sbjct: 73  LRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLN-NYDAENKLNDVLLIQLSSPANLS 131

Query: 122 RNVNPVALPRAQEGLRPGTLCTVAGWGRVSMR-RGTDTLREVQLRVQRDRQCLRIFGSYD 180
            +V  V LP+  + +  GT C   GWGRV         L+E+ + V            + 
Sbjct: 132 ASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTV---------VTFFC 182

Query: 181 PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGI---VSYGKSSGVPPEVFTRVSSFLPW 237
               IC    R +     GDSGGPL+C+ +  GI   V +G ++ + P+ FTRV+ ++ W
Sbjct: 183 RPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVDW 242

Query: 238 IRTTMR 243
           IR+T+R
Sbjct: 243 IRSTLR 248


>gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprotein
           [Homo sapiens]
          Length = 256

 Score =  152 bits (384), Expect = 3e-37
 Identities = 95/257 (36%), Positives = 134/257 (52%), Gaps = 22/257 (8%)

Query: 4   LLLLLAFLLP-TGAEAGE-IIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLT 61
           LLL L+FLL  T A+ G+ ++ G E  PHS+P+   L  +   G+  CG  L+   +VL+
Sbjct: 3   LLLTLSFLLASTAAQDGDKLLEGDECAPHSQPWQVALYER---GRFNCGASLISPHWVLS 59

Query: 62  AAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRN 121
           AAHC    + V LG HN+++R+  +Q  T  R I HP+Y  R+ +NDIMLL+L +  R N
Sbjct: 60  AAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLN 119

Query: 122 RNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRR-GT-----------DTLREVQLRVQRD 169
             V P  LP       PG  C V+GWG VS    GT           DTL    + +  D
Sbjct: 120 PQVRPAVLPTRCP--HPGEACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISD 177

Query: 170 RQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGK---SSGVPPE 226
             C + +        +C G       + +GDSGGPL+C  +  GIVS+G     +   P 
Sbjct: 178 TSCDKSYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKPG 237

Query: 227 VFTRVSSFLPWIRTTMR 243
           V+T+V  +L WIR TM+
Sbjct: 238 VYTKVCHYLEWIRETMK 254


>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
          Length = 247

 Score =  151 bits (382), Expect = 5e-37
 Identities = 89/249 (35%), Positives = 133/249 (53%), Gaps = 13/249 (5%)

Query: 1   MQPLLLLL---AFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVRED 57
           M PLL+L    A L     +  +I+GG     +S PY    Q+   +G   CGG L+ E 
Sbjct: 1   MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPY----QVSLNSGYHFCGGSLINEQ 56

Query: 58  FVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRR 117
           +V++A HC+ S I V LG HNI+  E  +Q I A + IRHPQY+++T+ NDIML++LS R
Sbjct: 57  WVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSR 116

Query: 118 VRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRG--TDTLREVQLRVQRDRQCLRI 175
              N  V+ ++LP A      GT C ++GWG  +       D L+ +   V    +C   
Sbjct: 117 AVINARVSTISLPTAPPA--TGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEAS 174

Query: 176 FGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGV--PPEVFTRVSS 233
           +         CVG     K + +GDSGGP++CN    G+VS+G        P V+T+V +
Sbjct: 175 YPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYN 234

Query: 234 FLPWIRTTM 242
           ++ WI+ T+
Sbjct: 235 YVKWIKNTI 243


>gi|42544239 complement factor D preproprotein [Homo sapiens]
          Length = 253

 Score =  149 bits (375), Expect = 3e-36
 Identities = 96/252 (38%), Positives = 135/252 (53%), Gaps = 23/252 (9%)

Query: 8   LAFLLPTGAEA------GEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLT 61
           LA L+  GA A      G I+GGRE+  H+RPYMA +Q+    G   CGG LV E +VL+
Sbjct: 7   LAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLN---GAHLCGGVLVAEQWVLS 63

Query: 62  AAHCW----GSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRR 117
           AAHC        + V LGAH++ + E +++     RA+ HP     TI +D++LLQLS +
Sbjct: 64  AAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEK 123

Query: 118 VRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQCLRIF 176
                 V P+   R    + PGTLC VAGWG V+   R  D+L+ V L V     C R  
Sbjct: 124 ATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRT 183

Query: 177 ---GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGK---SSGVPPEVFTR 230
              G+   R      +RR+   + KGDSGGPL+C  V  G+V+ G     +   P ++TR
Sbjct: 184 HHDGAITERLMCAESNRRD---SCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR 240

Query: 231 VSSFLPWIRTTM 242
           V+S+  WI + +
Sbjct: 241 VASYAAWIDSVL 252


>gi|91823048 kallikrein 14 preproprotein [Homo sapiens]
          Length = 267

 Score =  147 bits (372), Expect = 7e-36
 Identities = 88/245 (35%), Positives = 131/245 (53%), Gaps = 8/245 (3%)

Query: 4   LLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAA 63
           L +L   +  +  +  +IIGG      S+P+ A L +  P  +  CGG L+   +V+TAA
Sbjct: 24  LQVLAIAMTQSQEDENKIIGGHTCTRSSQPWQAAL-LAGPRRRFLCGGALLSGQWVITAA 82

Query: 64  HCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRN 123
           HC    + V LG HN++R E TQQ +   R + HP YN RT  ND+MLLQL +  R  R 
Sbjct: 83  HCGRPILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPARIGRA 142

Query: 124 VNPVALPRAQEGLRPGTLCTVAGWGRVS--MRRGTDTLREVQLRVQRDRQCLRIFGSYDP 181
           V P+ + +A     PGT C V+GWG +S  + R   +L+ V + +  D  C + +     
Sbjct: 143 VRPIEVTQACAS--PGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQKAYPRTIT 200

Query: 182 RRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYG-KSSGVP--PEVFTRVSSFLPWI 238
              +C G  +  K + +GDSGGPL+C     G+VS+G +   +P  P V+T +  +  WI
Sbjct: 201 PGMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVYTNLCKYRSWI 260

Query: 239 RTTMR 243
             TMR
Sbjct: 261 EETMR 265


>gi|5453676 granzyme A precursor [Homo sapiens]
          Length = 262

 Score =  147 bits (370), Expect = 1e-35
 Identities = 94/254 (37%), Positives = 142/254 (55%), Gaps = 20/254 (7%)

Query: 4   LLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAA 63
           L ++++ LL       +IIGG E  PHSRPYM  L +     ++ C G L+ +D+VLTAA
Sbjct: 12  LSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDR---KTICAGALIAKDWVLTAA 68

Query: 64  HCWGSNIN----VTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVR 119
           HC   N+N    V LGAH+I R E T+Q +  ++   +P Y+  T + D+ LLQL+ + +
Sbjct: 69  HC---NLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAK 125

Query: 120 RNRNVNPVALPRAQEGLRPGTLCTVAGWGRV-SMRRGTDTLREVQLRVQRDRQCL-RIFG 177
            N+ V  + LP+  + ++PGT+C VAGWGR  +    +DTLREV + +   + C  R   
Sbjct: 126 INKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHY 185

Query: 178 SYDP---RRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYG--KSSGVP--PEVFTR 230
           +++P      +C G  R  + +  GDSG PLLC  V  G+ S+G     G P  P V+  
Sbjct: 186 NFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYIL 245

Query: 231 VS-SFLPWIRTTMR 243
           +S   L WI  T++
Sbjct: 246 LSKKHLNWIIMTIK 259


>gi|4504235 granzyme K precursor [Homo sapiens]
          Length = 264

 Score =  144 bits (364), Expect = 6e-35
 Identities = 89/237 (37%), Positives = 133/237 (56%), Gaps = 18/237 (7%)

Query: 20  EIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCW-----GSNINVTL 74
           EIIGG+E  PHSRP+MA +Q     G   CGG L+   +VLTAAHC      G +  V L
Sbjct: 26  EIIGGKEVSPHSRPFMASIQY---GGHHVCGGVLIDPQWVLTAAHCQYRFTKGQSPTVVL 82

Query: 75  GAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQE 134
           GAH++ + E ++Q +  ++ I   +       NDIML++L    + N++V  + + R++ 
Sbjct: 83  GAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLVKLQTAAKLNKHVKMLHI-RSKT 141

Query: 135 GLRPGTLCTVAGWGRVS--MRRGTDTLREVQLRVQRDRQC-LRIFGSYDP---RRQICVG 188
            LR GT C V GWG       R +DTLREV + V   + C  + + + DP   +  +C G
Sbjct: 142 SLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKLCNSQSYYNGDPFITKDMVCAG 201

Query: 189 DRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGV--PPEVFTRVS-SFLPWIRTTM 242
           D + +K + KGDSGGPL+C  V H IVS G   GV   P ++T ++  +  WI++ +
Sbjct: 202 DAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGVATKPGIYTLLTKKYQTWIKSNL 258


>gi|11496281 kallikrein 13 precursor [Homo sapiens]
          Length = 277

 Score =  142 bits (359), Expect = 2e-34
 Identities = 88/249 (35%), Positives = 132/249 (53%), Gaps = 13/249 (5%)

Query: 11  LLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNI 70
           +L T   +G + GG    PHS+P+ A L +Q   G+  CGG LV   +VLTAAHC    +
Sbjct: 26  VLNTNGTSGFLPGGYTCFPHSQPWQAALLVQ---GRLLCGGVLVHPKWVLTAAHCLKEGL 82

Query: 71  NVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQ----NDIMLLQLSRRVRRNRNVNP 126
            V LG H + R E  +Q      +I HP+Y +        +DIMLL+L   V+    +  
Sbjct: 83  KVYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQT 142

Query: 127 VALPRAQEGLRPGTLCTVAGWGRVSMRRGT--DTLREVQLRVQRDRQCLRIFGSYDPRRQ 184
           + L      L PGT C V+GWG  +  +     TL+   ++++ D +C +++        
Sbjct: 143 LPLSHNNR-LTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPGKITDNM 201

Query: 185 ICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGK-SSGVP--PEVFTRVSSFLPWIRTT 241
           +C G +   K + +GDSGGPL+CN   +GIVS+G    G P  P V+TRVS ++ WIR T
Sbjct: 202 LCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRET 261

Query: 242 MRSFKLLDQ 250
           +R ++   Q
Sbjct: 262 IRKYETQQQ 270


>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  140 bits (354), Expect = 8e-34
 Identities = 89/248 (35%), Positives = 132/248 (53%), Gaps = 16/248 (6%)

Query: 4   LLLLLAFLLPTGA----EAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFV 59
           LLL+L F+    A    +  +I+GG     +S PY    Q+   +G   CGG L+ E +V
Sbjct: 3   LLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPY----QVSLNSGYHFCGGSLISEQWV 58

Query: 60  LTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVR 119
           ++A HC+ S I V LG HNI+  E  +Q I A + IRHP+YN RT+ NDI+L++LS    
Sbjct: 59  VSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAV 118

Query: 120 RNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQ---LRVQRDRQCLRIF 176
            N  V+ ++LP A      GT   ++GWG  ++  G D   E+Q     V    +C   +
Sbjct: 119 INSRVSAISLPTAPPA--AGTESLISGWGN-TLSSGADYPDELQCLDAPVLSQAECEASY 175

Query: 177 GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVS--YGKSSGVPPEVFTRVSSF 234
                    CVG     K + +GDSGGP++ N    GIVS  YG +    P V+T+V ++
Sbjct: 176 PGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNY 235

Query: 235 LPWIRTTM 242
           + WI+ T+
Sbjct: 236 VDWIKDTI 243


>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  140 bits (353), Expect = 1e-33
 Identities = 86/246 (34%), Positives = 132/246 (53%), Gaps = 16/246 (6%)

Query: 6   LLLAFLLPTGA----EAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLT 61
           L+LAF+    A    +  +I+GG     +S PY    Q+   +G   CGG L+ E +V++
Sbjct: 5   LILAFVGAAVAVPFDDDDKIVGGYTCEENSLPY----QVSLNSGSHFCGGSLISEQWVVS 60

Query: 62  AAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRN 121
           AAHC+ + I V LG HNI+  E  +Q I A + IRHP+YN+ T+ NDIML++LS     N
Sbjct: 61  AAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVIN 120

Query: 122 RNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGT---DTLREVQLRVQRDRQCLRIFGS 178
             V+ ++LP A      GT C ++GWG  ++  G    D L+ +   V    +C   +  
Sbjct: 121 ARVSTISLPTAPPA--AGTECLISGWGN-TLSFGADYPDELKCLDAPVLTQAECKASYPG 177

Query: 179 YDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVP--PEVFTRVSSFLP 236
                  CVG     K + + DSGGP++CN    G+VS+G        P V+T+V +++ 
Sbjct: 178 KITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVD 237

Query: 237 WIRTTM 242
           WI+ T+
Sbjct: 238 WIKDTI 243


>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
          Length = 304

 Score =  140 bits (352), Expect = 1e-33
 Identities = 81/228 (35%), Positives = 124/228 (54%), Gaps = 12/228 (5%)

Query: 20  EIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNI 79
           +I+GG     +S PY    Q+   +G   CGG L+ E +V++AAHC+ + I V LG HNI
Sbjct: 80  KIVGGYTCEENSLPY----QVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNI 135

Query: 80  QRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPG 139
           +  E  +Q I A + IRHP+YN+ T+ NDIML++LS     N  V+ ++LP A      G
Sbjct: 136 KVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPPA--AG 193

Query: 140 TLCTVAGWGRVSMRRGT---DTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAA 196
           T C ++GWG  ++  G    D L+ +   V    +C   +         CVG     K +
Sbjct: 194 TECLISGWGN-TLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDS 252

Query: 197 FKGDSGGPLLCNNVAHGIVSYGKSSGVP--PEVFTRVSSFLPWIRTTM 242
            + DSGGP++CN    G+VS+G        P V+T+V +++ WI+ T+
Sbjct: 253 CQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTI 300


>gi|4885369 granzyme M precursor [Homo sapiens]
          Length = 257

 Score =  139 bits (349), Expect = 3e-33
 Identities = 99/250 (39%), Positives = 138/250 (55%), Gaps = 21/250 (8%)

Query: 4   LLLLLAFLLPTGAEAG-EIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTA 62
           LL+L    L  G+  G +IIGGRE  PHSRPYMA LQ     G   CGG LV   +VLTA
Sbjct: 8   LLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRN---GSHLCGGVLVHPKWVLTA 64

Query: 63  AHCWG---SNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQ-RTIQNDIMLLQLSRRV 118
           AHC     + + + LG H +     T  HI A  AI+HP+Y     ++ND+ LLQL  +V
Sbjct: 65  AHCLAQRMAQLRLVLGLHTLDSPGLTF-HIKA--AIQHPRYKPVPALENDLALLQLDGKV 121

Query: 119 RRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSM-RRGTDTLREVQLRVQRDRQC--LRI 175
           + +R + P+ALP  ++ +  GT C++AGWG      R +  LRE+ L+V   R C   R 
Sbjct: 122 KPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRF 181

Query: 176 F-GSYDPRRQICVGDRRERKAAFKGDSGGPLLC--NNVAHGIVSYGK---SSGVPPEVFT 229
           + GS  P   +C+    + +A  KGDSGGPL+C    V  G++S+     +    P V T
Sbjct: 182 WNGSLSP-SMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVAT 240

Query: 230 RVSSFLPWIR 239
            V+ ++ WIR
Sbjct: 241 AVAPYVSWIR 250


>gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo
           sapiens]
          Length = 254

 Score =  138 bits (348), Expect = 4e-33
 Identities = 79/246 (32%), Positives = 137/246 (55%), Gaps = 12/246 (4%)

Query: 4   LLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAA 63
           L+L +A  L +G+   +II G +  PHS+P+ A L +++   +  C G LV   +VL+AA
Sbjct: 15  LILGVAGSLVSGS-CSQIINGEDCSPHSQPWQAALVMEN---ELFCSGVLVHPQWVLSAA 70

Query: 64  HCWGSNINVTLGAHNIQR-RENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNR 122
           HC+ ++  + LG H+++  +E   Q + A  ++RHP+YN+  + ND+ML++L   V  + 
Sbjct: 71  HCFQNSYTIGLGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESD 130

Query: 123 NVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPR 182
            +  +++  A +    G  C V+GWG ++  R    L+ V + V  +  C +++      
Sbjct: 131 TIRSISI--ASQCPTAGNSCLVSGWGLLANGRMPTVLQCVNVSVVSEEVCSKLYDPLYHP 188

Query: 183 RQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSS----GVPPEVFTRVSSFLPWI 238
              C G   ++K +  GDSGGPL+CN    G+VS+GK+     GV P V+T +  F  WI
Sbjct: 189 SMFCAGGGHDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGV-PGVYTNLCKFTEWI 247

Query: 239 RTTMRS 244
             T+++
Sbjct: 248 EKTVQA 253


>gi|61744424 kallikrein-related peptidase 6 isoform A preproprotein
           [Homo sapiens]
          Length = 244

 Score =  137 bits (346), Expect = 7e-33
 Identities = 79/248 (31%), Positives = 133/248 (53%), Gaps = 9/248 (3%)

Query: 1   MQPLLLLLAFLLPTGAEA-GEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFV 59
           M+ L+++L+ +    AE   +++ G      S PY A L     +G   CGG L+   +V
Sbjct: 1   MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYT---SGHLLCGGVLIHPLWV 57

Query: 60  LTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVR 119
           LTAAHC   N+ V LG HN+++RE++Q+  +  RA+ HP Y+  +   DIMLL+L+R  +
Sbjct: 58  LTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAK 117

Query: 120 RNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSY 179
            +  + P  LP  ++     T C + GWG+ +     DT++   + +    +C   +   
Sbjct: 118 LSELIQP--LPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQ 175

Query: 180 DPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGK---SSGVPPEVFTRVSSFLP 236
             +  +C GD +  K + +GDSGGPL+C +   G+VS+G     S   P V+T V  +  
Sbjct: 176 ITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTN 235

Query: 237 WIRTTMRS 244
           WI+ T+++
Sbjct: 236 WIQKTIQA 243


>gi|4506155 kallikrein-related peptidase 6 isoform A preproprotein
           [Homo sapiens]
          Length = 244

 Score =  137 bits (346), Expect = 7e-33
 Identities = 79/248 (31%), Positives = 133/248 (53%), Gaps = 9/248 (3%)

Query: 1   MQPLLLLLAFLLPTGAEA-GEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFV 59
           M+ L+++L+ +    AE   +++ G      S PY A L     +G   CGG L+   +V
Sbjct: 1   MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYT---SGHLLCGGVLIHPLWV 57

Query: 60  LTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVR 119
           LTAAHC   N+ V LG HN+++RE++Q+  +  RA+ HP Y+  +   DIMLL+L+R  +
Sbjct: 58  LTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAK 117

Query: 120 RNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSY 179
            +  + P  LP  ++     T C + GWG+ +     DT++   + +    +C   +   
Sbjct: 118 LSELIQP--LPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQ 175

Query: 180 DPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGK---SSGVPPEVFTRVSSFLP 236
             +  +C GD +  K + +GDSGGPL+C +   G+VS+G     S   P V+T V  +  
Sbjct: 176 ITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTN 235

Query: 237 WIRTTMRS 244
           WI+ T+++
Sbjct: 236 WIQKTIQA 243


>gi|4503549 neutrophil elastase preproprotein [Homo sapiens]
          Length = 267

 Score =  137 bits (346), Expect = 7e-33
 Identities = 90/242 (37%), Positives = 126/242 (52%), Gaps = 23/242 (9%)

Query: 6   LLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHC 65
           +L A LL   A A EI+GGR +RPH+ P+M  LQ++   G   CG  L+  +FV++AAHC
Sbjct: 15  VLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLR---GGHFCGATLIAPNFVMSAAHC 71

Query: 66  WGSNINV-----TLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR 120
             +N+NV      LGAHN+ RRE T+Q    +R   +  Y+   + NDI++LQL+     
Sbjct: 72  V-ANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENG-YDPVNLLNDIVILQLNGSATI 129

Query: 121 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRG-TDTLREVQLRVQRDRQCLRIFGSY 179
           N NV    LP     L  G  C   GWG +   RG    L+E+ + V           S 
Sbjct: 130 NANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTV---------VTSL 180

Query: 180 DPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSY---GKSSGVPPEVFTRVSSFLP 236
             R  +C   R  +     GDSG PL+CN + HGI S+   G +SG+ P+ F  V+ F+ 
Sbjct: 181 CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN 240

Query: 237 WI 238
           WI
Sbjct: 241 WI 242


>gi|47551347 protease, serine-like 1 [Homo sapiens]
          Length = 283

 Score =  137 bits (345), Expect = 9e-33
 Identities = 97/249 (38%), Positives = 127/249 (51%), Gaps = 15/249 (6%)

Query: 6   LLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHC 65
           L+L    P G+   +IIGG E  PHSRPYMA ++     GQ  CGGFL+R  +V++AAHC
Sbjct: 19  LMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRF---GGQHHCGGFLLRARWVVSAAHC 75

Query: 66  WGSNI----NVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRN 121
           +         V LGAH +   E TQQ         HP Y+  T  NDI LL+L+      
Sbjct: 76  FSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLG 135

Query: 122 RNVNPVALP-RAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQCLRIFGSY 179
             V  + LP R       GT C VAGWG VS        L E ++RV     C   +  +
Sbjct: 136 PAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSSWKGH 195

Query: 180 DPRRQICV--GDRRERKAAFKGDSGGPLLCNNVAHGIVSY-GKSSGVP--PEVFTRVSSF 234
                +C   GD   R+     DSGGPL+C N AHG+VS+ G   G P  P+V+T+VS+F
Sbjct: 196 LTLTMLCTRSGD-SHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAF 254

Query: 235 LPWIRTTMR 243
           + WI   +R
Sbjct: 255 VAWIWDVVR 263


>gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens]
          Length = 260

 Score =  136 bits (342), Expect = 2e-32
 Identities = 84/249 (33%), Positives = 130/249 (52%), Gaps = 14/249 (5%)

Query: 4   LLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAA 63
           LLL  A+   + A+  +++GG E +PHS+P+ A L       Q  CGG LV  ++VLTAA
Sbjct: 16  LLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAAL---FQGQQLLCGGVLVGGNWVLTAA 72

Query: 64  HCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQ---NDIMLLQLSRRVRR 120
           HC      V LG H++Q ++  +Q I   ++I HP YN   ++   +D+MLLQL  +   
Sbjct: 73  HCKKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASL 132

Query: 121 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGT--DTLREVQLRVQRDRQCLRIFGS 178
              V P++L  A    +PG  CTV+GWG V+  R    DTL   ++++   ++C   +  
Sbjct: 133 GSKVKPISL--ADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPG 190

Query: 179 YDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGK---SSGVPPEVFTRVSSFL 235
                 +C G  +      +GDSGGPL+C+    GI S+G         P V+T +  +L
Sbjct: 191 QITDGMVCAGSSKGADTC-QGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYL 249

Query: 236 PWIRTTMRS 244
            WI+  + S
Sbjct: 250 DWIKKIIGS 258


>gi|21464127 kallikrein 8 isoform 2 [Homo sapiens]
          Length = 305

 Score =  135 bits (341), Expect = 3e-32
 Identities = 80/237 (33%), Positives = 124/237 (52%), Gaps = 14/237 (5%)

Query: 16  AEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLG 75
           A+  +++GG E +PHS+P+ A L       Q  CGG LV  ++VLTAAHC      V LG
Sbjct: 73  AQEDKVLGGHECQPHSQPWQAAL---FQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLG 129

Query: 76  AHNIQRRENTQQHITARRAIRHPQYNQRTIQ---NDIMLLQLSRRVRRNRNVNPVALPRA 132
            H++Q ++  +Q I   ++I HP YN   ++   +D+MLLQL  +      V P++L  A
Sbjct: 130 DHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISL--A 187

Query: 133 QEGLRPGTLCTVAGWGRVSMRRGT--DTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDR 190
               +PG  CTV+GWG V+  R    DTL   ++++   ++C   +        +C G  
Sbjct: 188 DHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCAGSS 247

Query: 191 RERKAAFKGDSGGPLLCNNVAHGIVSYGK---SSGVPPEVFTRVSSFLPWIRTTMRS 244
           +      +GDSGGPL+C+    GI S+G         P V+T +  +L WI+  + S
Sbjct: 248 KGADTC-QGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIGS 303


>gi|21327705 stratum corneum chymotryptic enzyme preproprotein [Homo
           sapiens]
          Length = 253

 Score =  133 bits (334), Expect = 2e-31
 Identities = 89/250 (35%), Positives = 125/250 (50%), Gaps = 15/250 (6%)

Query: 5   LLLLAFLLPTGAEAGE---IIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLT 61
           +LLL+  L T  E  +   II G      S P+   L       Q  CGG LV E +VLT
Sbjct: 11  ILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALL---SGNQLHCGGVLVNERWVLT 67

Query: 62  AAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRN 121
           AAHC  +   V LG+  +  R    Q I A ++ RHP Y+ +T  ND+ML++L+ + R +
Sbjct: 68  AAHCKMNEYTVHLGSDTLGDRR--AQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLS 125

Query: 122 RNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGT--DTLREVQLRVQRDRQCLRIFGSY 179
             V  V LP   E   PGT CTV+GWG  +    T    L  V +++   + C +++   
Sbjct: 126 SMVKKVRLPSRCEP--PGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDL 183

Query: 180 DPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGK-SSGVP--PEVFTRVSSFLP 236
                +C G    +K A  GDSGGPL+C     G+VS+G    G P  P V+T+V  F  
Sbjct: 184 LENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTK 243

Query: 237 WIRTTMRSFK 246
           WI  TM+  +
Sbjct: 244 WINDTMKKHR 253


>gi|4826950 stratum corneum chymotryptic enzyme preproprotein [Homo
           sapiens]
          Length = 253

 Score =  133 bits (334), Expect = 2e-31
 Identities = 89/250 (35%), Positives = 125/250 (50%), Gaps = 15/250 (6%)

Query: 5   LLLLAFLLPTGAEAGE---IIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLT 61
           +LLL+  L T  E  +   II G      S P+   L       Q  CGG LV E +VLT
Sbjct: 11  ILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALL---SGNQLHCGGVLVNERWVLT 67

Query: 62  AAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRN 121
           AAHC  +   V LG+  +  R    Q I A ++ RHP Y+ +T  ND+ML++L+ + R +
Sbjct: 68  AAHCKMNEYTVHLGSDTLGDRR--AQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLS 125

Query: 122 RNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGT--DTLREVQLRVQRDRQCLRIFGSY 179
             V  V LP   E   PGT CTV+GWG  +    T    L  V +++   + C +++   
Sbjct: 126 SMVKKVRLPSRCEP--PGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDL 183

Query: 180 DPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGK-SSGVP--PEVFTRVSSFLP 236
                +C G    +K A  GDSGGPL+C     G+VS+G    G P  P V+T+V  F  
Sbjct: 184 LENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTK 243

Query: 237 WIRTTMRSFK 246
           WI  TM+  +
Sbjct: 244 WINDTMKKHR 253


>gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
          Length = 250

 Score =  129 bits (325), Expect = 2e-30
 Identities = 83/252 (32%), Positives = 130/252 (51%), Gaps = 16/252 (6%)

Query: 4   LLLLLAFLLPTGAEAGE--IIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLT 61
           +L L+   L TG   GE  II G E +PHS+P+ A L  ++   +  CG  L+   ++LT
Sbjct: 3   ILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKT---RLLCGATLIAPRWLLT 59

Query: 62  AAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYN----QRTIQNDIMLLQLSRR 117
           AAHC      V LG HN+Q+ E  +Q  TA  +  HP +N     +  +NDIML++++  
Sbjct: 60  AAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASP 119

Query: 118 VRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVS--MRRGTDTLREVQLRVQRDRQCLRI 175
           V     V P+ L  +   +  GT C ++GWG  S    R   TLR   + +   ++C   
Sbjct: 120 VSITWAVRPLTL--SSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENA 177

Query: 176 FGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGV---PPEVFTRVS 232
           +        +C   +   K + +GDSGGPL+CN    GI+S+G+        P V+T+V 
Sbjct: 178 YPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVC 237

Query: 233 SFLPWIRTTMRS 244
            ++ WI+ TM++
Sbjct: 238 KYVDWIQETMKN 249


>gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]
          Length = 282

 Score =  129 bits (325), Expect = 2e-30
 Identities = 83/252 (32%), Positives = 130/252 (51%), Gaps = 16/252 (6%)

Query: 4   LLLLLAFLLPTGAEAGE--IIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLT 61
           +L L+   L TG   GE  II G E +PHS+P+ A L  ++   +  CG  L+   ++LT
Sbjct: 35  ILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKT---RLLCGATLIAPRWLLT 91

Query: 62  AAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYN----QRTIQNDIMLLQLSRR 117
           AAHC      V LG HN+Q+ E  +Q  TA  +  HP +N     +  +NDIML++++  
Sbjct: 92  AAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASP 151

Query: 118 VRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVS--MRRGTDTLREVQLRVQRDRQCLRI 175
           V     V P+ L  +   +  GT C ++GWG  S    R   TLR   + +   ++C   
Sbjct: 152 VSITWAVRPLTL--SSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENA 209

Query: 176 FGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGV---PPEVFTRVS 232
           +        +C   +   K + +GDSGGPL+CN    GI+S+G+        P V+T+V 
Sbjct: 210 YPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVC 269

Query: 233 SFLPWIRTTMRS 244
            ++ WI+ TM++
Sbjct: 270 KYVDWIQETMKN 281


>gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
          Length = 250

 Score =  129 bits (325), Expect = 2e-30
 Identities = 83/252 (32%), Positives = 130/252 (51%), Gaps = 16/252 (6%)

Query: 4   LLLLLAFLLPTGAEAGE--IIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLT 61
           +L L+   L TG   GE  II G E +PHS+P+ A L  ++   +  CG  L+   ++LT
Sbjct: 3   ILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKT---RLLCGATLIAPRWLLT 59

Query: 62  AAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYN----QRTIQNDIMLLQLSRR 117
           AAHC      V LG HN+Q+ E  +Q  TA  +  HP +N     +  +NDIML++++  
Sbjct: 60  AAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASP 119

Query: 118 VRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVS--MRRGTDTLREVQLRVQRDRQCLRI 175
           V     V P+ L  +   +  GT C ++GWG  S    R   TLR   + +   ++C   
Sbjct: 120 VSITWAVRPLTL--SSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENA 177

Query: 176 FGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGV---PPEVFTRVS 232
           +        +C   +   K + +GDSGGPL+CN    GI+S+G+        P V+T+V 
Sbjct: 178 YPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVC 237

Query: 233 SFLPWIRTTMRS 244
            ++ WI+ TM++
Sbjct: 238 KYVDWIQETMKN 249


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  125 bits (314), Expect = 4e-29
 Identities = 83/238 (34%), Positives = 119/238 (50%), Gaps = 21/238 (8%)

Query: 21  IIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNIN-----VTLG 75
           I GG E+ PH  P+   L+     G  +CGG ++   ++LTAAHC     N     +  G
Sbjct: 575 IAGGEEACPHCWPWQVGLRF---LGDYQCGGAIINPVWILTAAHCVQLKNNPLSWTIIAG 631

Query: 76  AHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEG 135
            H+   +E+T+Q   A+  I H  +N  +  +DI L+QLS  +  N  V PV LP + E 
Sbjct: 632 DHDRNLKESTEQVRRAKHIIVHEDFNTLSYDSDIALIQLSSPLEYNSVVRPVCLPHSAEP 691

Query: 136 LRPGTLCTVAGWGRVSMRRG-TDTLREVQLRVQRDRQCLRIFGSYDP----RRQICVGDR 190
           L    +C V GWG +S   G    L+++Q+ V     C   + S  P     + IC G  
Sbjct: 692 LFSSEICAVTGWGSISADGGLASRLQQIQVHVLEREVCEHTYYSAHPGGITEKMICAGFA 751

Query: 191 RERKAAF-KGDSGGPLLCNN-----VAHGIVSYGKSSGVP--PEVFTRVSSFLPWIRT 240
              +  F +GDSGGPL+C +     V +GIVS+G     P  P VF RV  FL WI++
Sbjct: 752 ASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWIQS 809



 Score =  115 bits (287), Expect = 5e-26
 Identities = 77/232 (33%), Positives = 120/232 (51%), Gaps = 32/232 (13%)

Query: 49  CGGFLVREDFVLTAAHCWGS-------NINVTLGAHNIQRRENTQQHITARRAIRHPQYN 101
           CGG L++ED V+TAAHC  S       NI VT G +++ +++  +Q+I   + I HP+YN
Sbjct: 72  CGGSLIQEDRVVTAAHCLDSLSEKQLKNITVTSGEYSLFQKDKQEQNIPVSKIITHPEYN 131

Query: 102 QRTIQN-DIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTL 159
            R   + DI LL L  +V+    V P+ LP + + + PG LC  +GWG++S     ++ L
Sbjct: 132 SREYMSPDIALLYLKHKVKFGNAVQPICLPDSDDKVEPGILCLSSGWGKISKTSEYSNVL 191

Query: 160 REVQLRVQRDRQCLRIFGSYD----PRRQICVGDRRERKAAFKGDSGGPLLCNN-----V 210
           +E++L +  DR C  +  S +     R  +C G       A +GDSGGPL+C       +
Sbjct: 192 QEMELPIMDDRACNTVLKSMNLPPLGRTMLCAGFPDWGMDACQGDSGGPLVCRRGGGIWI 251

Query: 211 AHGIVSY--GKSSGVPP----------EVFTRVSSFLPWIRTTMRSFKLLDQ 250
             GI S+  G + G  P           +F++VS  + +I  T   F  LD+
Sbjct: 252 LAGITSWVAGCAGGSVPVRNNHVKASLGIFSKVSELMDFI--TQNLFTGLDR 301


>gi|5031829 kallikrein 2, prostatic isoform 1 [Homo sapiens]
          Length = 261

 Score =  123 bits (309), Expect = 1e-28
 Identities = 79/238 (33%), Positives = 112/238 (47%), Gaps = 21/238 (8%)

Query: 21  IIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQ 80
           I+GG E   HS+P+   +      G + CGG LV   +VLTAAHC   N  V LG HN+ 
Sbjct: 25  IVGGWECEKHSQPWQVAVYSH---GWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLF 81

Query: 81  RRENTQQHITARRAIRHPQYNQRTIQ-----------NDIMLLQLSRRVRRNRNVNPVAL 129
             E+T Q +    +  HP YN   ++           +D+MLL+LS   +    V  + L
Sbjct: 82  EPEDTGQRVPVSHSFPHPLYNMSLLKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGL 141

Query: 130 PRAQEGLRPGTLCTVAGWGRVSMRR--GTDTLREVQLRVQRDRQCLRIFGSYDPRRQICV 187
           P  +  L  GT C  +GWG +         +L+ V L +  +  C R +        +C 
Sbjct: 142 PTQEPAL--GTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEFMLCA 199

Query: 188 GDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPE---VFTRVSSFLPWIRTTM 242
           G     K    GDSGGPL+CN V  GI S+G      PE   V+T+V  +  WI+ T+
Sbjct: 200 GLWTGGKDTCGGDSGGPLVCNGVLQGITSWGPEPCALPEKPAVYTKVVHYRKWIKDTI 257


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,856,709
Number of Sequences: 37866
Number of extensions: 428058
Number of successful extensions: 1866
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 1248
Number of HSP's gapped (non-prelim): 186
length of query: 255
length of database: 18,247,518
effective HSP length: 100
effective length of query: 155
effective length of database: 14,460,918
effective search space: 2241442290
effective search space used: 2241442290
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.