Search of human proteins with 4503069

Search of human proteins with 4503069

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
         (360 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s...   735   0.0  
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ...   705   0.0  
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]        550   e-156
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ...   545   e-155
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ...   493   e-140
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]        482   e-136
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]         442   e-124
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph...   325   4e-89
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph...   325   4e-89
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta...   324   9e-89
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta...   324   9e-89
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]         322   3e-88
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]         322   3e-88
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s...   319   2e-87
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta...   316   2e-86
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta...   316   2e-86
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s...   310   1e-84
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ...   310   1e-84
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ...   310   1e-84
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph...   308   4e-84
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha...   308   4e-84
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s...   305   4e-83
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ...   305   4e-83
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ...   305   4e-83
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s...   303   2e-82
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ...   279   3e-75
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam...   254   1e-67
gi|149408126 nemo like kinase [Homo sapiens]                          236   3e-62
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s...   228   8e-60
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]        226   2e-59

>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
           sapiens]
          Length = 360

 Score =  735 bits (1898), Expect = 0.0
 Identities = 360/360 (100%), Positives = 360/360 (100%)

Query: 1   MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
           MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
Sbjct: 1   MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60

Query: 61  SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
           SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
Sbjct: 61  SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120

Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
           KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180

Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 240
           GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 240

Query: 241 TPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300
           TPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
Sbjct: 241 TPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300

Query: 301 QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES 360
           QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Sbjct: 301 QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES 360


>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
           sapiens]
          Length = 360

 Score =  705 bits (1820), Expect = 0.0
 Identities = 346/360 (96%), Positives = 352/360 (97%)

Query: 1   MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
           MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
Sbjct: 1   MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60

Query: 61  SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
           SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
Sbjct: 61  SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120

Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
           KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180

Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 240
           GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI+QL+ I+RL G
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240

Query: 241 TPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300
           TP A L+ ++ S  ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
Sbjct: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300

Query: 301 QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES 360
           QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Sbjct: 301 QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES 360


>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
          Length = 364

 Score =  550 bits (1416), Expect = e-156
 Identities = 257/351 (73%), Positives = 309/351 (88%)

Query: 1   MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
           MS  R  FYRQELNKT+WEVP+R Q L PVGSGAYGSVC+A+D +   +VAVKKLSRPFQ
Sbjct: 1   MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60

Query: 61  SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
           S+IHA+RTYRELRLLKH+KHENVIGLLDVFTPA S+E+F++VYLVT LMGADLNNIVKCQ
Sbjct: 61  SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120

Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
            L+D+HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNEDCEL+ILDFGLAR  D+EMT
Sbjct: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180

Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 240
           GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL G+ LFPG+D+I+QL++IM + G
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240

Query: 241 TPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300
           TP   ++ ++ S  AR YIQSL  MP+ + +++F GANPLA+DLL +MLVLDSD+R++AA
Sbjct: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300

Query: 301 QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 351
           +ALAHAYF+QYHDP+DEP A+PYD+S E+++  ++EWK LTY EV+SF PP
Sbjct: 301 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPP 351


>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
           sapiens]
          Length = 297

 Score =  545 bits (1404), Expect = e-155
 Identities = 266/280 (95%), Positives = 272/280 (97%)

Query: 1   MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
           MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
Sbjct: 1   MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60

Query: 61  SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
           SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
Sbjct: 61  SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120

Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
           KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180

Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 240
           GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI+QL+ I+RL G
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240

Query: 241 TPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPL 280
           TP A L+ ++ S  ARNYIQSLTQMPKMNFANVFIGANPL
Sbjct: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL 280


>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
           sapiens]
          Length = 307

 Score =  493 bits (1270), Expect = e-140
 Identities = 240/252 (95%), Positives = 246/252 (97%)

Query: 1   MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
           MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
Sbjct: 1   MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60

Query: 61  SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
           SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
Sbjct: 61  SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120

Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
           KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180

Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 240
           GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI+QL+ I+RL G
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240

Query: 241 TPPAYLINRMPS 252
           TP A L+ ++ S
Sbjct: 241 TPGAELLKKISS 252


>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
          Length = 367

 Score =  482 bits (1240), Expect = e-136
 Identities = 223/347 (64%), Positives = 280/347 (80%)

Query: 5   RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH 64
           R  FYRQE+ KT WEV   Y++L PVGSGAYG+VC+A D +TG +VA+KKL RPFQS + 
Sbjct: 8   RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67

Query: 65  AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 124
           AKR YRELRLLKHM+HENVIGLLDVFTP  +L++F D YLV   MG DL  ++K +KL +
Sbjct: 68  AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127

Query: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 184
           D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR  D EMTGYV 
Sbjct: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187

Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPA 244
           TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++TG+TLF G+DH++QL++IM++TGTPPA
Sbjct: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247

Query: 245 YLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304
             + R+ S EA+NY++ L ++ K +FA++   A+PLAV+LLEKMLVLD+++R+TA +ALA
Sbjct: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307

Query: 305 HAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 351
           H YF   HD +DEP    YD SF+  D  +DEWK +TY EV+SF PP
Sbjct: 308 HPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354


>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
          Length = 365

 Score =  442 bits (1138), Expect = e-124
 Identities = 211/344 (61%), Positives = 266/344 (77%), Gaps = 2/344 (0%)

Query: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
           FY+Q++NKT WE+P+ Y + + VGSGAYGSVC+A D ++G +VA+KKLSRPFQS I AKR
Sbjct: 9   FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68

Query: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
            YREL LLKHM+HENVIGLLDVFTPA SL  F D YLV   M  DL  I+  +  +++ +
Sbjct: 69  AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKI 127

Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 187
           Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EMTGYV TRW
Sbjct: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW 187

Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLI 247
           YRAPE++L+WMHYNQTVDIWSVGCIMAE+LTG+TLF G D+++QL QI+++TG P    +
Sbjct: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247

Query: 248 NRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307
            ++    A++YIQSL Q P+ +F  +F  A+P A DLLEKML LD DKR+TAAQAL H +
Sbjct: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307

Query: 308 FAQYHDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVP 350
           F  + DP++E  A  P+D S E   L +DEWK   Y E+++F P
Sbjct: 308 FEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351


>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
           [Homo sapiens]
          Length = 382

 Score =  325 bits (833), Expect = 4e-89
 Identities = 175/357 (49%), Positives = 232/357 (64%), Gaps = 19/357 (5%)

Query: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
           FY  ++  + + V +RYQ L P+GSGA G VCAAFDT  G+ VAVKKLSRPFQ+  HAKR
Sbjct: 10  FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69

Query: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
            YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  ++   +L  + +
Sbjct: 70  AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128

Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T+  MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188

Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAY 245
           R+YRAPE++L  M Y + VDIWSVGCIM EL+ G  +F GTDHI+Q  +++   GTP A 
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247

Query: 246 LINRMPSHEARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEKMLVLDS 293
            + ++     RNY+++  + P + F  +F                  A DLL KMLV+D 
Sbjct: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306

Query: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVISF 348
           DKRI+  +AL H Y   ++DP +     P  YD   E R+  I+EWK L Y EV+ +
Sbjct: 307 DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363


>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
           [Homo sapiens]
          Length = 424

 Score =  325 bits (833), Expect = 4e-89
 Identities = 175/357 (49%), Positives = 232/357 (64%), Gaps = 19/357 (5%)

Query: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
           FY  ++  + + V +RYQ L P+GSGA G VCAAFDT  G+ VAVKKLSRPFQ+  HAKR
Sbjct: 10  FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69

Query: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
            YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  ++   +L  + +
Sbjct: 70  AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128

Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T+  MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188

Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAY 245
           R+YRAPE++L  M Y + VDIWSVGCIM EL+ G  +F GTDHI+Q  +++   GTP A 
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247

Query: 246 LINRMPSHEARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEKMLVLDS 293
            + ++     RNY+++  + P + F  +F                  A DLL KMLV+D 
Sbjct: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306

Query: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVISF 348
           DKRI+  +AL H Y   ++DP +     P  YD   E R+  I+EWK L Y EV+ +
Sbjct: 307 DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363


>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
           [Homo sapiens]
          Length = 424

 Score =  324 bits (830), Expect = 9e-89
 Identities = 174/357 (48%), Positives = 233/357 (65%), Gaps = 19/357 (5%)

Query: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
           FY  ++  + + V +RYQ L P+GSGA G VCAAFDT  G+ VAVKKLSRPFQ+  HAKR
Sbjct: 10  FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69

Query: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
            YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  ++   +L  + +
Sbjct: 70  AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128

Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T+  MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188

Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAY 245
           R+YRAPE++L  M Y + VDIWSVGCIMAE++  + LFPG D+I+Q  +++   GTP A 
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247

Query: 246 LINRMPSHEARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEKMLVLDS 293
            + ++     RNY+++  + P + F  +F                  A DLL KMLV+D 
Sbjct: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306

Query: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVISF 348
           DKRI+  +AL H Y   ++DP +     P  YD   E R+  I+EWK L Y EV+ +
Sbjct: 307 DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363


>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
           [Homo sapiens]
          Length = 382

 Score =  324 bits (830), Expect = 9e-89
 Identities = 174/357 (48%), Positives = 233/357 (65%), Gaps = 19/357 (5%)

Query: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
           FY  ++  + + V +RYQ L P+GSGA G VCAAFDT  G+ VAVKKLSRPFQ+  HAKR
Sbjct: 10  FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69

Query: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
            YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  ++   +L  + +
Sbjct: 70  AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128

Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T+  MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188

Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAY 245
           R+YRAPE++L  M Y + VDIWSVGCIMAE++  + LFPG D+I+Q  +++   GTP A 
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247

Query: 246 LINRMPSHEARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEKMLVLDS 293
            + ++     RNY+++  + P + F  +F                  A DLL KMLV+D 
Sbjct: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306

Query: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVISF 348
           DKRI+  +AL H Y   ++DP +     P  YD   E R+  I+EWK L Y EV+ +
Sbjct: 307 DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363


>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  322 bits (826), Expect = 3e-88
 Identities = 163/341 (47%), Positives = 233/341 (68%), Gaps = 9/341 (2%)

Query: 17  IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76
           +++V  RY NLS +G GAYG VC+A+D    +RVA+KK+S PF+   + +RT RE+++L 
Sbjct: 18  VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 76

Query: 77  HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
             +HEN+IG+ D+   A ++E+  DVY+V  LM  DL  ++K Q L++DH+ + +YQILR
Sbjct: 77  RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 135

Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190
           GLKYIHSA+++HRDLKPSNL +N  C+LKI DFGLAR  D +      +T YVATRWYRA
Sbjct: 136 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 195

Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRM 250
           PEIMLN   Y +++DIWSVGCI+AE+L+ R +FPG  +++QL  I+ + G+P    +N +
Sbjct: 196 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255

Query: 251 PSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310
            + +ARNY+ SL    K+ +  +F  A+  A+DLL+KML  +  KRI   QALAH Y  Q
Sbjct: 256 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315

Query: 311 YHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISFVP 350
           Y+DP DEP+A+ P+    E  DL  ++ K L ++E   F P
Sbjct: 316 YYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 356


>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  322 bits (826), Expect = 3e-88
 Identities = 163/341 (47%), Positives = 233/341 (68%), Gaps = 9/341 (2%)

Query: 17  IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76
           +++V  RY NLS +G GAYG VC+A+D    +RVA+KK+S PF+   + +RT RE+++L 
Sbjct: 18  VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 76

Query: 77  HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
             +HEN+IG+ D+   A ++E+  DVY+V  LM  DL  ++K Q L++DH+ + +YQILR
Sbjct: 77  RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 135

Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190
           GLKYIHSA+++HRDLKPSNL +N  C+LKI DFGLAR  D +      +T YVATRWYRA
Sbjct: 136 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 195

Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRM 250
           PEIMLN   Y +++DIWSVGCI+AE+L+ R +FPG  +++QL  I+ + G+P    +N +
Sbjct: 196 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255

Query: 251 PSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310
            + +ARNY+ SL    K+ +  +F  A+  A+DLL+KML  +  KRI   QALAH Y  Q
Sbjct: 256 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315

Query: 311 YHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISFVP 350
           Y+DP DEP+A+ P+    E  DL  ++ K L ++E   F P
Sbjct: 316 YYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 356


>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
           sapiens]
          Length = 379

 Score =  319 bits (818), Expect = 2e-87
 Identities = 165/344 (47%), Positives = 233/344 (67%), Gaps = 9/344 (2%)

Query: 18  WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
           ++V  RY  L  +G GAYG V +A+D     RVA+KK+S PF+   + +RT RE+++L  
Sbjct: 36  FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94

Query: 78  MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137
            +HENVIG+ D+   A +LE   DVY+V  LM  DL  ++K Q+L++DH+ + +YQILRG
Sbjct: 95  FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153

Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191
           LKYIHSA+++HRDLKPSNL +N  C+LKI DFGLAR  D E      +T YVATRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213

Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMP 251
           EIMLN   Y +++DIWSVGCI+AE+L+ R +FPG  +++QL  I+ + G+P    +N + 
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273

Query: 252 SHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311
           + +ARNY+QSL    K+ +A +F  ++  A+DLL++ML  + +KRIT  +ALAH Y  QY
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333

Query: 312 HDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD 354
           +DP DEPVA +P+  + E  DL  +  K L + E   F P  L+
Sbjct: 334 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLE 377


>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
           [Homo sapiens]
          Length = 427

 Score =  316 bits (810), Expect = 2e-86
 Identities = 173/362 (47%), Positives = 234/362 (64%), Gaps = 21/362 (5%)

Query: 2   SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
           S+    FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+
Sbjct: 4   SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63

Query: 62  IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
             HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V  LM A+L  +++  +
Sbjct: 64  QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122

Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
           L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   M
Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182

Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLT 239
           T YV TR+YRAPE++L  M Y + VDIWSVGCIM E++ G  LFPGTDHI+Q  +++   
Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241

Query: 240 GTP-PAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLE 286
           GTP P ++    P+   R Y+++  +    +F  +F           N L    A DLL 
Sbjct: 242 GTPCPEFMKKLQPT--VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLS 299

Query: 287 KMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDE 344
           KMLV+D+ KRI+  +AL H Y   ++DP +     P   D+  + R+  I+EWK L Y E
Sbjct: 300 KMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359

Query: 345 VI 346
           V+
Sbjct: 360 VM 361


>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
           [Homo sapiens]
          Length = 384

 Score =  316 bits (810), Expect = 2e-86
 Identities = 173/362 (47%), Positives = 234/362 (64%), Gaps = 21/362 (5%)

Query: 2   SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
           S+    FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+
Sbjct: 4   SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63

Query: 62  IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
             HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V  LM A+L  +++  +
Sbjct: 64  QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122

Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
           L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   M
Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182

Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLT 239
           T YV TR+YRAPE++L  M Y + VDIWSVGCIM E++ G  LFPGTDHI+Q  +++   
Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241

Query: 240 GTP-PAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLE 286
           GTP P ++    P+   R Y+++  +    +F  +F           N L    A DLL 
Sbjct: 242 GTPCPEFMKKLQPT--VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLS 299

Query: 287 KMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDE 344
           KMLV+D+ KRI+  +AL H Y   ++DP +     P   D+  + R+  I+EWK L Y E
Sbjct: 300 KMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359

Query: 345 VI 346
           V+
Sbjct: 360 VM 361


>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
           sapiens]
          Length = 422

 Score =  310 bits (795), Expect = 1e-84
 Identities = 170/357 (47%), Positives = 232/357 (64%), Gaps = 21/357 (5%)

Query: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
           FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+  HAKR
Sbjct: 48  FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107

Query: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
            YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  +++  +L  + +
Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166

Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   MT YV T
Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226

Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP-PA 244
           R+YRAPE++L  M Y + VDIWSVGCIM E++  + LFPG D+I+Q  +++   GTP P 
Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285

Query: 245 YLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEKMLVLD 292
           ++    P+   RNY+++  +   + F  +F  +        N L    A DLL KMLV+D
Sbjct: 286 FMKKLQPT--VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343

Query: 293 SDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVIS 347
             KRI+   AL H Y   ++DP +     P  YD+  + R+  I+EWK L Y EV++
Sbjct: 344 PAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400


>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
           sapiens]
          Length = 464

 Score =  310 bits (795), Expect = 1e-84
 Identities = 170/357 (47%), Positives = 232/357 (64%), Gaps = 21/357 (5%)

Query: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
           FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+  HAKR
Sbjct: 48  FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107

Query: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
            YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  +++  +L  + +
Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166

Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   MT YV T
Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226

Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP-PA 244
           R+YRAPE++L  M Y + VDIWSVGCIM E++  + LFPG D+I+Q  +++   GTP P 
Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285

Query: 245 YLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEKMLVLD 292
           ++    P+   RNY+++  +   + F  +F  +        N L    A DLL KMLV+D
Sbjct: 286 FMKKLQPT--VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343

Query: 293 SDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVIS 347
             KRI+   AL H Y   ++DP +     P  YD+  + R+  I+EWK L Y EV++
Sbjct: 344 PAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400


>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
           sapiens]
          Length = 426

 Score =  310 bits (795), Expect = 1e-84
 Identities = 170/357 (47%), Positives = 232/357 (64%), Gaps = 21/357 (5%)

Query: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
           FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+  HAKR
Sbjct: 10  FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 69

Query: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
            YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  +++  +L  + +
Sbjct: 70  AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 128

Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188

Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP-PA 244
           R+YRAPE++L  M Y + VDIWSVGCIM E++  + LFPG D+I+Q  +++   GTP P 
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 247

Query: 245 YLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEKMLVLD 292
           ++    P+   RNY+++  +   + F  +F  +        N L    A DLL KMLV+D
Sbjct: 248 FMKKLQPT--VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 305

Query: 293 SDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVIS 347
             KRI+   AL H Y   ++DP +     P  YD+  + R+  I+EWK L Y EV++
Sbjct: 306 PAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 362


>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
           [Homo sapiens]
          Length = 427

 Score =  308 bits (790), Expect = 4e-84
 Identities = 169/362 (46%), Positives = 233/362 (64%), Gaps = 21/362 (5%)

Query: 2   SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
           S+    FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+
Sbjct: 4   SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63

Query: 62  IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
             HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V  LM A+L  +++  +
Sbjct: 64  QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122

Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
           L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   M
Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182

Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLT 239
           T YV TR+YRAPE++L  M Y + VD+WSVGCIM E++  + LFPG D+I+Q  +++   
Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQL 241

Query: 240 GTP-PAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLE 286
           GTP P ++    P+   R Y+++  +    +F  +F           N L    A DLL 
Sbjct: 242 GTPCPEFMKKLQPT--VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLS 299

Query: 287 KMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDE 344
           KMLV+D+ KRI+  +AL H Y   ++DP +     P   D+  + R+  I+EWK L Y E
Sbjct: 300 KMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359

Query: 345 VI 346
           V+
Sbjct: 360 VM 361


>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
           [Homo sapiens]
          Length = 384

 Score =  308 bits (790), Expect = 4e-84
 Identities = 169/362 (46%), Positives = 233/362 (64%), Gaps = 21/362 (5%)

Query: 2   SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
           S+    FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+
Sbjct: 4   SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63

Query: 62  IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
             HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V  LM A+L  +++  +
Sbjct: 64  QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122

Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
           L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   M
Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182

Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLT 239
           T YV TR+YRAPE++L  M Y + VD+WSVGCIM E++  + LFPG D+I+Q  +++   
Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQL 241

Query: 240 GTP-PAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLE 286
           GTP P ++    P+   R Y+++  +    +F  +F           N L    A DLL 
Sbjct: 242 GTPCPEFMKKLQPT--VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLS 299

Query: 287 KMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDE 344
           KMLV+D+ KRI+  +AL H Y   ++DP +     P   D+  + R+  I+EWK L Y E
Sbjct: 300 KMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359

Query: 345 VI 346
           V+
Sbjct: 360 VM 361


>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  305 bits (781), Expect = 4e-83
 Identities = 159/340 (46%), Positives = 219/340 (64%), Gaps = 9/340 (2%)

Query: 18  WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
           ++V + Y+ +  +G+GAYG V +A    TG +VA+KK+   F  + +AKRT REL++LKH
Sbjct: 49  FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108

Query: 78  MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILR 136
            KH+N+I + D+  P     EF  VY+V  LM +DL+ I+   Q LT +HV++ +YQ+LR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168

Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYR 189
           GLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR            MT YVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228

Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINR 249
           APE+ML+   Y Q +D+WSVGCI  E+L  R LFPG ++++QLQ IM + GTP   +I  
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288

Query: 250 MPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309
           + +   R YIQSL     + +  V+ GA+  A+ LL +ML  +   RI+AA AL H + A
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348

Query: 310 QYHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISF 348
           +YHDPDDEP  A P+D +F+   L  +  K     E+  F
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388


>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  305 bits (781), Expect = 4e-83
 Identities = 159/340 (46%), Positives = 219/340 (64%), Gaps = 9/340 (2%)

Query: 18  WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
           ++V + Y+ +  +G+GAYG V +A    TG +VA+KK+   F  + +AKRT REL++LKH
Sbjct: 49  FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108

Query: 78  MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILR 136
            KH+N+I + D+  P     EF  VY+V  LM +DL+ I+   Q LT +HV++ +YQ+LR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168

Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYR 189
           GLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR            MT YVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228

Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINR 249
           APE+ML+   Y Q +D+WSVGCI  E+L  R LFPG ++++QLQ IM + GTP   +I  
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288

Query: 250 MPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309
           + +   R YIQSL     + +  V+ GA+  A+ LL +ML  +   RI+AA AL H + A
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348

Query: 310 QYHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISF 348
           +YHDPDDEP  A P+D +F+   L  +  K     E+  F
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388


>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  305 bits (781), Expect = 4e-83
 Identities = 159/340 (46%), Positives = 219/340 (64%), Gaps = 9/340 (2%)

Query: 18  WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
           ++V + Y+ +  +G+GAYG V +A    TG +VA+KK+   F  + +AKRT REL++LKH
Sbjct: 49  FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108

Query: 78  MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILR 136
            KH+N+I + D+  P     EF  VY+V  LM +DL+ I+   Q LT +HV++ +YQ+LR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168

Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYR 189
           GLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR            MT YVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228

Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINR 249
           APE+ML+   Y Q +D+WSVGCI  E+L  R LFPG ++++QLQ IM + GTP   +I  
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288

Query: 250 MPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309
           + +   R YIQSL     + +  V+ GA+  A+ LL +ML  +   RI+AA AL H + A
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348

Query: 310 QYHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISF 348
           +YHDPDDEP  A P+D +F+   L  +  K     E+  F
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388


>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
           sapiens]
          Length = 357

 Score =  303 bits (775), Expect = 2e-82
 Identities = 153/311 (49%), Positives = 215/311 (69%), Gaps = 8/311 (2%)

Query: 18  WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
           ++V  RY  L  +G GAYG V +A+D     RVA+KK+S PF+   + +RT RE+++L  
Sbjct: 36  FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94

Query: 78  MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137
            +HENVIG+ D+   A +LE   DVY+V  LM  DL  ++K Q+L++DH+ + +YQILRG
Sbjct: 95  FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153

Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191
           LKYIHSA+++HRDLKPSNL +N  C+LKI DFGLAR  D E      +T YVATRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213

Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMP 251
           EIMLN   Y +++DIWSVGCI+AE+L+ R +FPG  +++QL  I+ + G+P    +N + 
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273

Query: 252 SHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311
           + +ARNY+QSL    K+ +A +F  ++  A+DLL++ML  + +KRIT  +ALAH Y  QY
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333

Query: 312 HDPDDEPVADP 322
           +DP DE    P
Sbjct: 334 YDPTDEVGQSP 344


>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
           sapiens]
          Length = 335

 Score =  279 bits (713), Expect = 3e-75
 Identities = 153/344 (44%), Positives = 208/344 (60%), Gaps = 53/344 (15%)

Query: 18  WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
           ++V  RY  L  +G GAYG V +A+D     RVA+KK+S PF+   + +RT RE+++L  
Sbjct: 36  FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94

Query: 78  MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137
            +HENVIG+ D+   A +LE   DVY+V  LM  DL  ++K Q+L++DH+ + +YQILRG
Sbjct: 95  FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153

Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191
           LKYIHSA+++HRDLKPSNL +N  C+LKI DFGLAR  D E      +T YVATRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213

Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMP 251
           EIMLN   Y +++DIWSVGCI+AE+L+ R +FPG  +++QL  I                
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI---------------- 257

Query: 252 SHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311
                                       LA+DLL++ML  + +KRIT  +ALAH Y  QY
Sbjct: 258 ----------------------------LALDLLDRMLTFNPNKRITVEEALAHPYLEQY 289

Query: 312 HDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD 354
           +DP DEPVA +P+  + E  DL  +  K L + E   F P  L+
Sbjct: 290 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLE 333


>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
           [Homo sapiens]
          Length = 242

 Score =  254 bits (648), Expect = 1e-67
 Identities = 131/224 (58%), Positives = 165/224 (73%), Gaps = 4/224 (1%)

Query: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
           FY  ++  + + V +RYQ L P+GSGA G VCAAFDT  G+ VAVKKLSRPFQ+  HAKR
Sbjct: 10  FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69

Query: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
            YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  ++   +L  + +
Sbjct: 70  AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128

Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T+  MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188

Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229
           R+YRAPE++L  M Y + VDIWSVGCIM EL+ G  +F GTD I
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231


>gi|149408126 nemo like kinase [Homo sapiens]
          Length = 527

 Score =  236 bits (601), Expect = 3e-62
 Identities = 142/345 (41%), Positives = 196/345 (56%), Gaps = 28/345 (8%)

Query: 29  PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88
           P+G GA+G V +  D + G RVA+KK+   FQ+++  KR +REL++L   KH+NV+  LD
Sbjct: 143 PIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALD 202

Query: 89  VFTPARSLEEFNDVYLVTHLMGADLNNI-VKCQKLTDDHVQFLIYQILRGLKYIHSADII 147
           +  P   ++ F ++Y+VT LM +DL+ I V  Q L+ DHV+  +YQILRGLKY+HSA I+
Sbjct: 203 ILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGIL 261

Query: 148 HRDLKPSNLAVNEDCELKILDFGLARHTD-DE---MTGYVATRWYRAPEIMLNWMHYNQT 203
           HRD+KP NL VN +C LKI DFGLAR  + DE   MT  V T++YRAPEI++   HY+  
Sbjct: 262 HRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNA 321

Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLT 263
           +DIWSVGCI AELL  R LF     I QL  I  L GTP    +         + ++   
Sbjct: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPH 381

Query: 264 QMPKMNFANVFIG-ANPLAVDLLEKMLVLDSDKRITAAQALAHAYF----AQYH------ 312
           + P +         A   AV LL +MLV D  KRI+A  ALAH Y      +YH      
Sbjct: 382 KQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKC 441

Query: 313 ----------DPDDEPVADP-YDQSFESRDLLIDEWKSLTYDEVI 346
                       D EPV +P +D +FE     + + K + +  ++
Sbjct: 442 CFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFIL 486


>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
           sapiens]
          Length = 677

 Score =  228 bits (580), Expect = 8e-60
 Identities = 121/249 (48%), Positives = 161/249 (64%), Gaps = 9/249 (3%)

Query: 109 MGADLNNIV-KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 167
           M +DL+ I+   Q LT +HV++ +YQ+LRGLKY+HSA +IHRDLKPSNL VNE+CELKI 
Sbjct: 1   MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIG 60

Query: 168 DFGLARHTDDE-------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR 220
           DFG+AR            MT YVATRWYRAPE+ML+   Y Q +D+WSVGCI  E+L  R
Sbjct: 61  DFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARR 120

Query: 221 TLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPL 280
            LFPG ++++QLQ IM + GTP   +I  + +   R YIQSL     + +  V+ GA+  
Sbjct: 121 QLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQ 180

Query: 281 AVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEP-VADPYDQSFESRDLLIDEWKS 339
           A+ LL +ML  +   RI+AA AL H + A+YHDPDDEP  A P+D +F+   L  +  K 
Sbjct: 181 ALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKE 240

Query: 340 LTYDEVISF 348
               E+  F
Sbjct: 241 AIVAEIEDF 249


>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
          Length = 544

 Score =  226 bits (577), Expect = 2e-59
 Identities = 131/340 (38%), Positives = 193/340 (56%), Gaps = 17/340 (5%)

Query: 20  VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM- 78
           +  RY     +G GAYG V  A D +TG  VA+KK+   F+    A+RT+RE+ LL+   
Sbjct: 9   IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68

Query: 79  KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD-HVQFLIYQILRG 137
            H N+I LLDV       E   D+YLV   M  DLN +++   L  D HV+ + YQ+LR 
Sbjct: 69  DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124

Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--------DDEMTGYVATRWYR 189
            +++HS  ++HRD KPSN+ ++ +C +K+ DFGLAR          D  +T YVATRWYR
Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184

Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINR 249
           APE++L+   Y   VD+WS+GCI+ E+L GR LFPGT  ++QL+ I+     P    +  
Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244

Query: 250 MPSHEARNYIQSLTQMPKMNF-ANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308
           + S    + +  L   P+    A +    +P A+DLL ++LV   DKR++A QAL H Y 
Sbjct: 245 LGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYV 304

Query: 309 AQYHDPDDE--PVADPYDQSFESRDLLIDEWKSLTYDEVI 346
            ++H P DE    AD   ++ E   L + E++S  Y  ++
Sbjct: 305 QRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMIL 344


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,076,867
Number of Sequences: 37866
Number of extensions: 595984
Number of successful extensions: 3281
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 733
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 1067
Number of HSP's gapped (non-prelim): 996
length of query: 360
length of database: 18,247,518
effective HSP length: 103
effective length of query: 257
effective length of database: 14,347,320
effective search space: 3687261240
effective search space used: 3687261240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.