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Search of human proteins with 4502873
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
(869 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens] 1754 0.0
gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens] 652 0.0
gi|167466160 chloride channel 7 isoform b [Homo sapiens] 528 e-150
gi|14149607 chloride channel 7 isoform a [Homo sapiens] 528 e-150
gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens] 485 e-137
gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens] 485 e-137
gi|55770840 chloride channel 3 isoform e [Homo sapiens] 228 2e-59
gi|55770838 chloride channel 3 isoform b [Homo sapiens] 228 2e-59
gi|189217923 chloride channel 5 isoform a [Homo sapiens] 221 2e-57
gi|189217921 chloride channel 5 isoform a [Homo sapiens] 221 2e-57
gi|4557473 chloride channel 5 isoform b [Homo sapiens] 221 2e-57
gi|153252026 chloride channel 4 [Homo sapiens] 217 3e-56
gi|156104869 chloride channel 2 [Homo sapiens] 165 2e-40
gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens] 165 2e-40
gi|155969705 chloride channel Kb [Homo sapiens] 122 1e-27
gi|112382220 chloride channel Ka isoform 1 [Homo sapiens] 119 9e-27
gi|112382222 chloride channel Ka isoform 2 [Homo sapiens] 119 9e-27
gi|13654235 regulator of G-protein signaling 20 isoform b [Homo ... 36 0.18
gi|41281805 regulator of G-protein signaling 20 isoform a [Homo ... 36 0.18
gi|169204828 PREDICTED: hypothetical protein [Homo sapiens] 35 0.39
gi|169205567 PREDICTED: hypothetical protein [Homo sapiens] 35 0.39
gi|169204182 PREDICTED: hypothetical protein [Homo sapiens] 35 0.39
gi|4557415 cystathionine-beta-synthase [Homo sapiens] 33 1.5
gi|239754592 PREDICTED: hypothetical LOC100129126 [Homo sapiens] 32 3.3
gi|239749130 PREDICTED: hypothetical LOC100129126 [Homo sapiens] 32 3.3
gi|239743202 PREDICTED: hypothetical LOC100129126 [Homo sapiens] 32 3.3
gi|239508877 PREDICTED: hypothetical LOC100129126 [Homo sapiens] 32 3.3
gi|38708169 sorting nexin 25 [Homo sapiens] 32 3.3
gi|45504382 DnaJ (Hsp40) homolog, subfamily C, member 5 [Homo sa... 31 4.4
gi|29126218 DnaJ (Hsp40) homolog, subfamily C, member 5 beta [Ho... 31 4.4
>gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
Length = 869
Score = 1754 bits (4543), Expect = 0.0
Identities = 869/869 (100%), Positives = 869/869 (100%)
Query: 1 MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP 60
MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP
Sbjct: 1 MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP 60
Query: 61 YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC 120
YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC
Sbjct: 61 YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC 120
Query: 121 SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL 180
SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL
Sbjct: 121 SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL 180
Query: 181 LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRD 240
LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRD
Sbjct: 181 LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRD 240
Query: 241 FVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQF 300
FVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQF
Sbjct: 241 FVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQF 300
Query: 301 GSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAK 360
GSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAK
Sbjct: 301 GSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAK 360
Query: 361 YRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTED 420
YRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTED
Sbjct: 361 YRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTED 420
Query: 421 VNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTY 480
VNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTY
Sbjct: 421 VNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTY 480
Query: 481 GISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAAFLGGVVRMTISL 540
GISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAAFLGGVVRMTISL
Sbjct: 481 GISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAAFLGGVVRMTISL 540
Query: 541 TVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLR 600
TVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLR
Sbjct: 541 TVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLR 600
Query: 601 ASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFK 660
ASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFK
Sbjct: 601 ASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFK 660
Query: 661 KSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNL 720
KSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNL
Sbjct: 661 KSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNL 720
Query: 721 YPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAED 780
YPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAED
Sbjct: 721 YPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAED 780
Query: 781 YPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNA 840
YPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNA
Sbjct: 781 YPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNA 840
Query: 841 VGEIVGIITRHNLTYEFLQARLRQHYQTI 869
VGEIVGIITRHNLTYEFLQARLRQHYQTI
Sbjct: 841 VGEIVGIITRHNLTYEFLQARLRQHYQTI 869
>gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]
Length = 353
Score = 652 bits (1683), Expect = 0.0
Identities = 318/318 (100%), Positives = 318/318 (100%)
Query: 1 MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP 60
MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP
Sbjct: 1 MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP 60
Query: 61 YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC 120
YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC
Sbjct: 61 YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC 120
Query: 121 SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL 180
SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL
Sbjct: 121 SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL 180
Query: 181 LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRD 240
LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRD
Sbjct: 181 LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRD 240
Query: 241 FVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQF 300
FVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQF
Sbjct: 241 FVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQF 300
Query: 301 GSWGSFQLPGLLNFGEFK 318
GSWGSFQLPGLLNFGEFK
Sbjct: 301 GSWGSFQLPGLLNFGEFK 318
>gi|167466160 chloride channel 7 isoform b [Homo sapiens]
Length = 781
Score = 528 bits (1360), Expect = e-150
Identities = 313/724 (43%), Positives = 446/724 (61%), Gaps = 48/724 (6%)
Query: 48 YESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQ 107
YESLDYD N +LE +++ R E +W++ IG+ TGLV F+D V
Sbjct: 70 YESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAG 129
Query: 108 LKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYL 166
LK+ V++ ++++ ++KG L+ SLL N FV + S++V IEPVAAGSGIP++KC+L
Sbjct: 130 LKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 189
Query: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
NGVK+P +VRL+TL+ KV GV+ SV GGL VGKEGPMIHSGSV+ AG+ Q +S SL++
Sbjct: 190 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 249
Query: 227 FNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMS 286
F YFR D +KRDFVSAGAAAGV+AAFGAP+GG LFSLEEG+SFWNQ LTW++ F SM
Sbjct: 250 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 309
Query: 287 ATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGL 346
+TFTLNF S I G+ PGL+NFG F DS+K +T ++ F+ MGV+GG+
Sbjct: 310 STFTLNFVLS-IYHGNMWDLSSPGLINFGRF---DSEKMA--YTIHEIPVFIAMGVVGGV 363
Query: 347 LGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSS 406
LGA FN LN L +R+R +H +P L +V+E++LV+ VT V FV +C+ +
Sbjct: 364 LGAVFNALNYWLTMFRIRYIH-RPCL-QVIEAVLVAAVTATVAFVLIYSSRDCQPL---- 417
Query: 407 QIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQ-DGTFSPVTL 465
Q G+ S+ LQ+ FC + YN MA FFN E +++ LFH G+++P+TL
Sbjct: 418 QGGSMSYPLQL-----------FCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTL 466
Query: 466 ALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYS--GTFAL 523
LF ++YF LACWTYG++V +G+F+PSLL GAA+GRL + SY+ I++ G +AL
Sbjct: 467 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLF-GISLSYLTGAAIWADPGKYAL 525
Query: 524 IGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLR 583
+GAAA LGG+VRMT+SLTVI++E+T+ +TYG PIM+ LM AK GD F +G+YD+H+ L+
Sbjct: 526 MGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQ 585
Query: 584 GVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTV--HHAFPVVTENRG 641
VP L WE V L A ++M +T + ++ +V +L T H+ FPVV
Sbjct: 586 SVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADD 645
Query: 642 NEKEFMKGNQLISNNIKFKKSSILTRAG-----EQRKRSQSMK-SYPSSELRNMCDEHIA 695
+ ++G L S I K + ++R R + + +YP + H++
Sbjct: 646 TQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYP--RFPPIQSIHVS 703
Query: 696 SEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLIL---RSQLVT 752
+E DL + M P P P ++ + + FR L L++ R+Q+V
Sbjct: 704 QDERECTMDLSEFM-----NPSPYTVPQEASLP--RVFKLFRALGLRHLVVVDNRNQVVG 756
Query: 753 LLVR 756
L+ R
Sbjct: 757 LVTR 760
Score = 90.9 bits (224), Expect = 5e-18
Identities = 46/117 (39%), Positives = 68/117 (58%)
Query: 737 RPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLN 796
+P GLILRSQL+ LL V S Q RL + + YPR+P I + ++
Sbjct: 647 QPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDE 706
Query: 797 PRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNL 853
+D++ +MNPSP+TV + +VF LFR +GLRHL VV+ ++VG++TR +L
Sbjct: 707 RECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 763
>gi|14149607 chloride channel 7 isoform a [Homo sapiens]
Length = 805
Score = 528 bits (1360), Expect = e-150
Identities = 313/724 (43%), Positives = 446/724 (61%), Gaps = 48/724 (6%)
Query: 48 YESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQ 107
YESLDYD N +LE +++ R E +W++ IG+ TGLV F+D V
Sbjct: 94 YESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAG 153
Query: 108 LKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYL 166
LK+ V++ ++++ ++KG L+ SLL N FV + S++V IEPVAAGSGIP++KC+L
Sbjct: 154 LKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
Query: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
NGVK+P +VRL+TL+ KV GV+ SV GGL VGKEGPMIHSGSV+ AG+ Q +S SL++
Sbjct: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
Query: 227 FNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMS 286
F YFR D +KRDFVSAGAAAGV+AAFGAP+GG LFSLEEG+SFWNQ LTW++ F SM
Sbjct: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333
Query: 287 ATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGL 346
+TFTLNF S I G+ PGL+NFG F DS+K +T ++ F+ MGV+GG+
Sbjct: 334 STFTLNFVLS-IYHGNMWDLSSPGLINFGRF---DSEKMA--YTIHEIPVFIAMGVVGGV 387
Query: 347 LGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSS 406
LGA FN LN L +R+R +H +P L +V+E++LV+ VT V FV +C+ +
Sbjct: 388 LGAVFNALNYWLTMFRIRYIH-RPCL-QVIEAVLVAAVTATVAFVLIYSSRDCQPL---- 441
Query: 407 QIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQ-DGTFSPVTL 465
Q G+ S+ LQ+ FC + YN MA FFN E +++ LFH G+++P+TL
Sbjct: 442 QGGSMSYPLQL-----------FCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTL 490
Query: 466 ALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYS--GTFAL 523
LF ++YF LACWTYG++V +G+F+PSLL GAA+GRL + SY+ I++ G +AL
Sbjct: 491 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLF-GISLSYLTGAAIWADPGKYAL 549
Query: 524 IGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLR 583
+GAAA LGG+VRMT+SLTVI++E+T+ +TYG PIM+ LM AK GD F +G+YD+H+ L+
Sbjct: 550 MGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQ 609
Query: 584 GVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTV--HHAFPVVTENRG 641
VP L WE V L A ++M +T + ++ +V +L T H+ FPVV
Sbjct: 610 SVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADD 669
Query: 642 NEKEFMKGNQLISNNIKFKKSSILTRAG-----EQRKRSQSMK-SYPSSELRNMCDEHIA 695
+ ++G L S I K + ++R R + + +YP + H++
Sbjct: 670 TQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYP--RFPPIQSIHVS 727
Query: 696 SEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLIL---RSQLVT 752
+E DL + M P P P ++ + + FR L L++ R+Q+V
Sbjct: 728 QDERECTMDLSEFM-----NPSPYTVPQEASLP--RVFKLFRALGLRHLVVVDNRNQVVG 780
Query: 753 LLVR 756
L+ R
Sbjct: 781 LVTR 784
Score = 90.9 bits (224), Expect = 5e-18
Identities = 46/117 (39%), Positives = 68/117 (58%)
Query: 737 RPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLN 796
+P GLILRSQL+ LL V S Q RL + + YPR+P I + ++
Sbjct: 671 QPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDE 730
Query: 797 PRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNL 853
+D++ +MNPSP+TV + +VF LFR +GLRHL VV+ ++VG++TR +L
Sbjct: 731 RECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 787
>gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]
Length = 308
Score = 485 bits (1249), Expect = e-137
Identities = 236/236 (100%), Positives = 236/236 (100%)
Query: 1 MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP 60
MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP
Sbjct: 1 MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP 60
Query: 61 YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC 120
YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC
Sbjct: 61 YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC 120
Query: 121 SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL 180
SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL
Sbjct: 121 SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL 180
Query: 181 LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDR 236
LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDR
Sbjct: 181 LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDR 236
>gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]
Length = 320
Score = 485 bits (1249), Expect = e-137
Identities = 236/236 (100%), Positives = 236/236 (100%)
Query: 1 MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP 60
MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP
Sbjct: 1 MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDP 60
Query: 61 YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC 120
YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC
Sbjct: 61 YLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEEC 120
Query: 121 SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL 180
SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL
Sbjct: 121 SQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTL 180
Query: 181 LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDR 236
LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDR
Sbjct: 181 LCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDR 236
>gi|55770840 chloride channel 3 isoform e [Homo sapiens]
Length = 866
Score = 228 bits (580), Expect = 2e-59
Identities = 182/627 (29%), Positives = 286/627 (45%), Gaps = 131/627 (20%)
Query: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121
W+VV G+ +G + +D T LK G+ +T+ EE C
Sbjct: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
Query: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166
Q G ++ + + + L+F FLA SL+ + P A GSGIPE+K L
Sbjct: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
Query: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
+G + G + TL+ K + ++ +VA GL +GKEGP++H G
Sbjct: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCG-----------NIFS 297
Query: 227 FNFP-YFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSM 285
+ FP Y ++ KR+ +SA +AAGV+ AFGAPIGG LFSLEE S ++ W+ F ++
Sbjct: 298 YLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAAL 357
Query: 286 SATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGG 345
A F L +G+ +L +L + E+ W +L F+++GV GG
Sbjct: 358 VAAFVLR------SINPFGNSRL--VLFYVEYHTP--------WYLFELFPFILLGVFGG 401
Query: 346 LLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVF-----------VASM 394
L GA F N + R K VLE ++V+ +T V+ F +
Sbjct: 402 LWGAFFIRANIAWCRRRKSTKFGK---YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKE 458
Query: 395 VLGECRQMSSSS--QIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQ 452
+ +C + SSS ND ++ +D+ P A +
Sbjct: 459 LFTDCGPLESSSLCDYRNDMNASKIVDDI-----------------------PDRPAGI- 494
Query: 453 LFHQDGTFSPV-TLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSY- 510
G +S + L L + ++ +T+GI VPSGLF+PS+ GA GR+V ++
Sbjct: 495 -----GVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLA 549
Query: 511 --------------IGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLP 556
+G I G +A++GAAA LGGV RMT+SL VI+ E T + Y +P
Sbjct: 550 YYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVP 609
Query: 557 IMVTLMVAKWTGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPN------L 609
+M +M +KW GD F + GIY+ H+ L G P L+ + E L A+D+M P
Sbjct: 610 LMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTL-AADVMRPRRNDPPLA 668
Query: 610 TYVYPHTRIQSLVSILRTTVHHAFPVV 636
+ + + +++ T ++ FPV+
Sbjct: 669 VLTQDNMTVDDIENMINETSYNGFPVI 695
Score = 40.0 bits (92), Expect = 0.009
Identities = 28/82 (34%), Positives = 49/82 (59%), Gaps = 4/82 (4%)
Query: 788 HDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGI 847
H L +PR + + ++ SPFTV+ +T + V ++FR +GLR +V G ++GI
Sbjct: 737 HTPSLPAESPRPL-KLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQC-LVTHNGIVLGI 794
Query: 848 ITRHNLTYEFLQARLRQHYQTI 869
IT+ N+ E L+ +L+QH + +
Sbjct: 795 ITKKNI-LEHLE-QLKQHVEPL 814
>gi|55770838 chloride channel 3 isoform b [Homo sapiens]
Length = 818
Score = 228 bits (580), Expect = 2e-59
Identities = 182/627 (29%), Positives = 286/627 (45%), Gaps = 131/627 (20%)
Query: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121
W+VV G+ +G + +D T LK G+ +T+ EE C
Sbjct: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
Query: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166
Q G ++ + + + L+F FLA SL+ + P A GSGIPE+K L
Sbjct: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
Query: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
+G + G + TL+ K + ++ +VA GL +GKEGP++H G
Sbjct: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCG-----------NIFS 297
Query: 227 FNFP-YFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSM 285
+ FP Y ++ KR+ +SA +AAGV+ AFGAPIGG LFSLEE S ++ W+ F ++
Sbjct: 298 YLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAAL 357
Query: 286 SATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGG 345
A F L +G+ +L +L + E+ W +L F+++GV GG
Sbjct: 358 VAAFVLR------SINPFGNSRL--VLFYVEYHTP--------WYLFELFPFILLGVFGG 401
Query: 346 LLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVF-----------VASM 394
L GA F N + R K VLE ++V+ +T V+ F +
Sbjct: 402 LWGAFFIRANIAWCRRRKSTKFGK---YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKE 458
Query: 395 VLGECRQMSSSS--QIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQ 452
+ +C + SSS ND ++ +D+ P A +
Sbjct: 459 LFTDCGPLESSSLCDYRNDMNASKIVDDI-----------------------PDRPAGI- 494
Query: 453 LFHQDGTFSPV-TLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSY- 510
G +S + L L + ++ +T+GI VPSGLF+PS+ GA GR+V ++
Sbjct: 495 -----GVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLA 549
Query: 511 --------------IGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLP 556
+G I G +A++GAAA LGGV RMT+SL VI+ E T + Y +P
Sbjct: 550 YYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVP 609
Query: 557 IMVTLMVAKWTGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPN------L 609
+M +M +KW GD F + GIY+ H+ L G P L+ + E L A+D+M P
Sbjct: 610 LMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTL-AADVMRPRRNDPPLA 668
Query: 610 TYVYPHTRIQSLVSILRTTVHHAFPVV 636
+ + + +++ T ++ FPV+
Sbjct: 669 VLTQDNMTVDDIENMINETSYNGFPVI 695
Score = 36.6 bits (83), Expect = 0.10
Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 2/72 (2%)
Query: 788 HDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGI 847
H L +PR + + ++ SPFTV+ +T + V ++FR +GLR +V G ++GI
Sbjct: 737 HTPSLPAESPRPL-KLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQC-LVTHNGRLLGI 794
Query: 848 ITRHNLTYEFLQ 859
IT+ ++ Q
Sbjct: 795 ITKKDILRHMAQ 806
>gi|189217923 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 221 bits (563), Expect = 2e-57
Identities = 187/587 (31%), Positives = 283/587 (48%), Gaps = 83/587 (14%)
Query: 138 LTFVFLA-SLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
L F FLA SL+ + P A GSGIPE+K L+G + G + TL+ K + ++ +V+ GL
Sbjct: 218 LLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLS 277
Query: 197 VGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA 256
+GKEGP++H G L FN Y +++ +R+ +SA AAAGV+ AFGA
Sbjct: 278 LGKEGPLVHVACCCGNILCHC---------FN-KYRKNEAKRREVLSAAAAAGVSVAFGA 327
Query: 257 PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGE 316
PIGG LFSLEE S ++ W+ F ++ A FTL +G+ +L +L + E
Sbjct: 328 PIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLR------SINPFGNSRL--VLFYVE 379
Query: 317 FKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVL 376
F W +L F+++G+ GGL GA F + +A R R K V+
Sbjct: 380 FHTP--------WHLFELVPFILLGIFGGLWGALF--IRTNIAWCRKRKTTQLGK-YPVI 428
Query: 377 ESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYN 436
E L+V+ +T ++ F E +MS+S I ++ D + C
Sbjct: 429 EVLVVTAITAILAFP-----NEYTRMSTSELIS------ELFNDCGLLDSSKLC------ 471
Query: 437 DMATLFFNPQESAILQLFHQDGTFSPV-TLALFFVLYFLLACWTYGISVPSGLFVPSLLC 495
D F + + G +S + LAL +L ++ +T+G+ +PSGLF+PS+
Sbjct: 472 DYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAV 531
Query: 496 GAAFGRLVA-------------NVLKSYIGLGH--IYSGTFALIGAAAFLGGVVRMTISL 540
GA GRL+ V S+ G I G +A++GAAA LGGV RMT+SL
Sbjct: 532 GAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSL 591
Query: 541 TVILIESTNEITYGLPIMVTLMVAKWTGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKL 599
VI+ E T + Y +P+M M +KW D + GIYD H+ L G P LE + E K
Sbjct: 592 VVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEF-AHKT 650
Query: 600 RASDIMEPN-----LTYVYPHT-RIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQL- 652
A D+M+P LT + + ++ + +I+ T + FPVV E + + G L
Sbjct: 651 LAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVV---SRESQRLVGFVLR 707
Query: 653 ------ISNNIKFKKSSILTRAGEQRKRSQSMKSY--PSSELRNMCD 691
I N K + + T + S + Y P+ +LRN+ D
Sbjct: 708 RDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILD 754
Score = 33.9 bits (76), Expect = 0.67
Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 1/50 (2%)
Query: 810 SPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQ 859
SPFTV+ T + V ++FR +GLR +V G ++GIIT+ ++ Q
Sbjct: 756 SPFTVTDLTPMEIVVDIFRKLGLRQC-LVTHNGRLLGIITKKDVLKHIAQ 804
>gi|189217921 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 221 bits (563), Expect = 2e-57
Identities = 187/587 (31%), Positives = 283/587 (48%), Gaps = 83/587 (14%)
Query: 138 LTFVFLA-SLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
L F FLA SL+ + P A GSGIPE+K L+G + G + TL+ K + ++ +V+ GL
Sbjct: 218 LLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLS 277
Query: 197 VGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA 256
+GKEGP++H G L FN Y +++ +R+ +SA AAAGV+ AFGA
Sbjct: 278 LGKEGPLVHVACCCGNILCHC---------FN-KYRKNEAKRREVLSAAAAAGVSVAFGA 327
Query: 257 PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGE 316
PIGG LFSLEE S ++ W+ F ++ A FTL +G+ +L +L + E
Sbjct: 328 PIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLR------SINPFGNSRL--VLFYVE 379
Query: 317 FKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVL 376
F W +L F+++G+ GGL GA F + +A R R K V+
Sbjct: 380 FHTP--------WHLFELVPFILLGIFGGLWGALF--IRTNIAWCRKRKTTQLGK-YPVI 428
Query: 377 ESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYN 436
E L+V+ +T ++ F E +MS+S I ++ D + C
Sbjct: 429 EVLVVTAITAILAFP-----NEYTRMSTSELIS------ELFNDCGLLDSSKLC------ 471
Query: 437 DMATLFFNPQESAILQLFHQDGTFSPV-TLALFFVLYFLLACWTYGISVPSGLFVPSLLC 495
D F + + G +S + LAL +L ++ +T+G+ +PSGLF+PS+
Sbjct: 472 DYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAV 531
Query: 496 GAAFGRLVA-------------NVLKSYIGLGH--IYSGTFALIGAAAFLGGVVRMTISL 540
GA GRL+ V S+ G I G +A++GAAA LGGV RMT+SL
Sbjct: 532 GAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSL 591
Query: 541 TVILIESTNEITYGLPIMVTLMVAKWTGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKL 599
VI+ E T + Y +P+M M +KW D + GIYD H+ L G P LE + E K
Sbjct: 592 VVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEF-AHKT 650
Query: 600 RASDIMEPN-----LTYVYPHT-RIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQL- 652
A D+M+P LT + + ++ + +I+ T + FPVV E + + G L
Sbjct: 651 LAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVV---SRESQRLVGFVLR 707
Query: 653 ------ISNNIKFKKSSILTRAGEQRKRSQSMKSY--PSSELRNMCD 691
I N K + + T + S + Y P+ +LRN+ D
Sbjct: 708 RDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILD 754
Score = 33.9 bits (76), Expect = 0.67
Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 1/50 (2%)
Query: 810 SPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQ 859
SPFTV+ T + V ++FR +GLR +V G ++GIIT+ ++ Q
Sbjct: 756 SPFTVTDLTPMEIVVDIFRKLGLRQC-LVTHNGRLLGIITKKDVLKHIAQ 804
>gi|4557473 chloride channel 5 isoform b [Homo sapiens]
Length = 746
Score = 221 bits (563), Expect = 2e-57
Identities = 187/587 (31%), Positives = 283/587 (48%), Gaps = 83/587 (14%)
Query: 138 LTFVFLA-SLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
L F FLA SL+ + P A GSGIPE+K L+G + G + TL+ K + ++ +V+ GL
Sbjct: 148 LLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLS 207
Query: 197 VGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA 256
+GKEGP++H G L FN Y +++ +R+ +SA AAAGV+ AFGA
Sbjct: 208 LGKEGPLVHVACCCGNILCHC---------FN-KYRKNEAKRREVLSAAAAAGVSVAFGA 257
Query: 257 PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGE 316
PIGG LFSLEE S ++ W+ F ++ A FTL +G+ +L +L + E
Sbjct: 258 PIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLR------SINPFGNSRL--VLFYVE 309
Query: 317 FKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVL 376
F W +L F+++G+ GGL GA F + +A R R K V+
Sbjct: 310 FHTP--------WHLFELVPFILLGIFGGLWGALF--IRTNIAWCRKRKTTQLGK-YPVI 358
Query: 377 ESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYN 436
E L+V+ +T ++ F E +MS+S I ++ D + C
Sbjct: 359 EVLVVTAITAILAFP-----NEYTRMSTSELIS------ELFNDCGLLDSSKLC------ 401
Query: 437 DMATLFFNPQESAILQLFHQDGTFSPV-TLALFFVLYFLLACWTYGISVPSGLFVPSLLC 495
D F + + G +S + LAL +L ++ +T+G+ +PSGLF+PS+
Sbjct: 402 DYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAV 461
Query: 496 GAAFGRLVA-------------NVLKSYIGLGH--IYSGTFALIGAAAFLGGVVRMTISL 540
GA GRL+ V S+ G I G +A++GAAA LGGV RMT+SL
Sbjct: 462 GAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSL 521
Query: 541 TVILIESTNEITYGLPIMVTLMVAKWTGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKL 599
VI+ E T + Y +P+M M +KW D + GIYD H+ L G P LE + E K
Sbjct: 522 VVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEF-AHKT 580
Query: 600 RASDIMEPN-----LTYVYPHT-RIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQL- 652
A D+M+P LT + + ++ + +I+ T + FPVV E + + G L
Sbjct: 581 LAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVV---SRESQRLVGFVLR 637
Query: 653 ------ISNNIKFKKSSILTRAGEQRKRSQSMKSY--PSSELRNMCD 691
I N K + + T + S + Y P+ +LRN+ D
Sbjct: 638 RDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILD 684
Score = 33.9 bits (76), Expect = 0.67
Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 1/50 (2%)
Query: 810 SPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQ 859
SPFTV+ T + V ++FR +GLR +V G ++GIIT+ ++ Q
Sbjct: 686 SPFTVTDLTPMEIVVDIFRKLGLRQC-LVTHNGRLLGIITKKDVLKHIAQ 734
>gi|153252026 chloride channel 4 [Homo sapiens]
Length = 760
Score = 217 bits (553), Expect = 3e-56
Identities = 191/625 (30%), Positives = 297/625 (47%), Gaps = 112/625 (17%)
Query: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQT----SVEEC---------------- 120
W+V+ IG+ G + +D V T LK GV + S E+C
Sbjct: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
Query: 121 -----------SQKGCLA--LSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166
+G A L+ L + + L F FLA SL+ + P A GSGIPE+K L
Sbjct: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTIL 190
Query: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
+G + G + TLL K + ++ V+ GL +GKEGP++H G F S K
Sbjct: 191 SGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCG----NFFSSLFSK-- 244
Query: 227 FNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMS 286
Y +++ +R+ +SA AAAGV+ AFGAPIGG LFSLEE S ++ W+ F ++
Sbjct: 245 ----YSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 300
Query: 287 ATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGL 346
A FTL +G+ +L +L + E+ W +L F+++GV GGL
Sbjct: 301 AAFTLR------SINPFGNSRL--VLFYVEYHTP--------WYMAELFPFILLGVFGGL 344
Query: 347 LGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSS- 405
G F + +A R R K VLE ++V+ +T ++ + RQ +S
Sbjct: 345 WGTLF--IRCNIAWCRRRKTTRLGK-YPVLEVIVVTAITAIIAYPNPYT----RQSTSEL 397
Query: 406 -SQIGNDSFQL---QVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFS 461
S++ ND L Q+ + +N T P D D P + Q
Sbjct: 398 ISELFNDCGALESSQLCDYINDPNMT--RPVDDIPD------RPAGVGVYTAMWQ----- 444
Query: 462 PVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYI---------- 511
LAL + ++ +T+G+ +PSGLF+PS+ GA GR+V ++
Sbjct: 445 ---LALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFR 501
Query: 512 -----GLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKW 566
G + G +A++GAAA LGGV RMT+SL VI+ E T + Y +P+M + +KW
Sbjct: 502 NWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKW 561
Query: 567 TGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKLRASDIM-----EPNLTYVYPHT-RIQ 619
D F K GIY+ H+ L G P L+ + E L A+D+M EP L+ + + ++
Sbjct: 562 VADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTL-ATDVMRPRRGEPPLSVLTQDSMTVE 620
Query: 620 SLVSILRTTVHHAFPVVTENRGNEK 644
+ ++++ T ++ FPVV +R +E+
Sbjct: 621 DVETLIKETDYNGFPVVV-SRDSER 644
Score = 38.9 bits (89), Expect = 0.021
Identities = 20/53 (37%), Positives = 33/53 (62%), Gaps = 1/53 (1%)
Query: 807 MNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQ 859
+N SPFTV+ +T + V ++FR +GLR +V G ++GIIT+ ++ Q
Sbjct: 697 LNLSPFTVTDHTPMETVVDIFRKLGLRQC-LVTRSGRLLGIITKKDVLRHMAQ 748
>gi|156104869 chloride channel 2 [Homo sapiens]
Length = 898
Score = 165 bits (417), Expect = 2e-40
Identities = 193/832 (23%), Positives = 341/832 (40%), Gaps = 146/832 (17%)
Query: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFN--- 137
W+ + +G+ LV +D+ + Q ++ +G LL+ L +
Sbjct: 91 WIFLVLLGLLMALVSWVMDYAIAACLQ---------AQQWMSRGLNTSILLQYLAWVTYP 141
Query: 138 -LTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
+ F A ++ P A GSGIPE+K L GV + + L+T + KV+G+ ++ G+
Sbjct: 142 VVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMP 201
Query: 197 VGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA 256
+GKEGP +H S+ A L +F S+ F Y R+ + ++A A GV F A
Sbjct: 202 LGKEGPFVHIASMCAALLSKFLSL------FGGIYENESRN-TEMLAAACAVGVGCCFAA 254
Query: 257 PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGS--------FQL 308
PIGG LFS+E S+F+ W+ F +ATF+ FR W F+
Sbjct: 255 PIGGVLFSIEVTSTFFAVRNYWRGFF---AATFSAFIFR---VLAVWNRDEETITALFKT 308
Query: 309 PGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKY--RMRNV 366
L+F + +L F V+G+ G GA F LN+++ + + + +
Sbjct: 309 RFRLDFP-------------FDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTI 355
Query: 367 HPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIK 426
+ R+L LV+L+ + + F Q+S + VT N +
Sbjct: 356 NRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETL--------VTLFDNRTWV 407
Query: 427 TFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPS 486
+ + +NP + + +TL +F ++ F ++ I VP
Sbjct: 408 RQGLVEELEPPSTSQAWNPPRANVF-----------LTLVIFILMKFWMSALATTIPVPC 456
Query: 487 GLFVPSLLCGAAFGRLVANVLKSYIGLG--------HIYSGTFALIGAAAFLGGVVRMTI 538
G F+P + GAAFGRLV + ++ G I G +A++GAAA L G V T+
Sbjct: 457 GAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAA-LAGAVTHTV 515
Query: 539 SLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLE---WETEVE 595
S VI+ E T +I + LP+M+ +++A +YD + ++ +P L W +
Sbjct: 516 STAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRH-Q 574
Query: 596 MDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISN 655
++R DIM ++ PH + LR +H +G ++ + +
Sbjct: 575 QYRVRVEDIMVRDV----PHVALSCTFRDLRLALH-------RTKGRMLALVESPESMIL 623
Query: 656 NIKFKKSSILTRAGEQ---RKRSQSMKSYPSSELRNMCDE------------HIASEEPA 700
++S ++ G Q +R Q M+ +++ + D+ + +E+ A
Sbjct: 624 LGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSA 683
Query: 701 ------EKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLL 754
E L+ L+R + NL + S + G+ LRS
Sbjct: 684 FPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESA-----------GIALRSLF---- 728
Query: 755 VRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLT-LLNPRMIVDVTPY------- 806
C S +AS+ S + R D DL ++P I++
Sbjct: 729 ----CGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLDEPVN 784
Query: 807 -----MNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNL 853
++P+PF + T + + +F +G+ H V ++G ++GI+T L
Sbjct: 785 FSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDH-AYVTSIGRLIGIVTLKEL 835
>gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
Length = 988
Score = 165 bits (417), Expect = 2e-40
Identities = 205/866 (23%), Positives = 352/866 (40%), Gaps = 116/866 (13%)
Query: 35 TQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDN--KKGRRYEAVKWMVVFAIGVCTG 92
+ E+D +P+K S D D Y + + + + RR W+ + +G+
Sbjct: 70 SDREQDIGMPKKTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDWIFLVLLGLLMA 129
Query: 93 LVGLFVDFF-VRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LI 150
LV +D+ + K+ Q + L L L + F L + ++L LI
Sbjct: 130 LVSWSMDYVSAKSLQAYKWSYAQ-------MQPSLPLQFLVWVTFPLVLILFSALFCHLI 182
Query: 151 EPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVV 210
P A GSGIPE+K L GV + + ++ + KV+ + + G+ VGKEGP +H S+
Sbjct: 183 SPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASIC 242
Query: 211 GAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSS 270
A L +F S+ + PY+ S D ++ G A GV FG P+GG LFS+E S+
Sbjct: 243 AAVLSKFMSVFCG--VYEQPYYYS-----DILTVGCAVGVGCCFGTPLGGVLFSIEVTST 295
Query: 271 FWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWT 330
++ W+ F +ATF+ FR + + + + L D K
Sbjct: 296 YFAVRNYWRGFF---AATFSAFVFRV-LAVWNKDAVTITALFRTNFRMDFPFDLK----- 346
Query: 331 AMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLES---LLVSLVTTV 387
+L F +G+ GLLGA F L++++ M V L + L L +VT V
Sbjct: 347 --ELPAFAAIGICCGLLGAVFVYLHRQV----MLGVRKHKALSQFLAKHRLLYPGIVTFV 400
Query: 388 VVF------VASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATL 441
+ + + GE + S + +++ ++ D S + +
Sbjct: 401 IASFTFPPGMGQFMAGELMPREAISTLFDNNTWVKHAGDPESL------------GQSAV 448
Query: 442 FFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGR 501
+ +P+ + ++ +F LFFV+ F ++ + +P G F+P + GAAFGR
Sbjct: 449 WIHPRVNVVIIIF------------LFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGR 496
Query: 502 LVANVLKSYIGLGHIYS--------GTFALIGAAAFLGGVVRMTISLTVILIESTNEITY 553
LV ++ G ++ G +A+IGAAA L G V T+S VI E T +I +
Sbjct: 497 LVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAA-LTGAVSHTVSTAVICFELTGQIAH 555
Query: 554 GLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLE---WETEVEMDKLRASDIMEPNLT 610
LP+MV +++A +YD + ++ +P L W ++ + DIM ++
Sbjct: 556 ILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGW-NQLSKYTIFVEDIMVRDVK 614
Query: 611 YVYPHTRIQSLVSILRTTVHHAFPVVTENRGN---------------EKEFMKGNQLISN 655
+V L ++L+TT P+V ++ +L +
Sbjct: 615 FVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQALLQRHLCPERRLRAA 674
Query: 656 NIKFKKSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLL-QQMLERRY 714
+K S L G+ R + + P E A + E EDL + L
Sbjct: 675 QEMARKLSELPYDGKARLAGEGLPGAPPGR-----PESFAFVDEDEDEDLSGKSELPPSL 729
Query: 715 TPYPNLYPDQSPSE-------DWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSA 767
+P+ SP E E P I +S L LL R + +
Sbjct: 730 ALHPSTTAPLSPEEPNGPLPGHKQQPEAPEPAGQRPSIFQSLLHCLLGRARPTKKKTTQD 789
Query: 768 SQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLF 827
S + D +I + L+ + D + ++ SPF + T + + LF
Sbjct: 790 STDLV-------DNMSPEEIEAWEQEQLSQPVCFD-SCCIDQSPFQLVEQTTLHKTHTLF 841
Query: 828 RTMGLRHLPVVNAVGEIVGIITRHNL 853
+GL HL V ++G++ G++ L
Sbjct: 842 SLLGL-HLAYVTSMGKLRGVLALEEL 866
>gi|155969705 chloride channel Kb [Homo sapiens]
Length = 687
Score = 122 bits (306), Expect = 1e-27
Identities = 128/514 (24%), Positives = 219/514 (42%), Gaps = 72/514 (14%)
Query: 150 IEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGG--LFVGKEGPMIHSG 207
I P + GSGIPEVK L GV + + ++ KV+G+ ++A G LF+GK GP +H
Sbjct: 114 ITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLS 173
Query: 208 SVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEE 267
++ A L + ++ ++ + + + + + + A AA GVA F AP G LFS+E
Sbjct: 174 VMMAAYLGRVRTTTIGEPE-------NKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEV 226
Query: 268 GSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCH 327
SS ++ W+ F + F F+L + N + + K
Sbjct: 227 MSSHFSVWDYWRGFFAATCGAF---------------MFRLLAVFNSEQETITSLYKTSF 271
Query: 328 L----WTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSL 383
+ ++ FFV +G + G+LG+ + +R+ +RN KL+ + + +L
Sbjct: 272 RVDVPFDLPEIFFFVALGGLCGILGSAY-LFCQRIFFGFIRNNRFSSKLLATSKPVYSAL 330
Query: 384 VTTVVVFV-----ASMVLGECRQMSS--SSQIGNDSFQLQVTEDVNSSIKTFFCPN---- 432
T V+ + A L M S N S+ L +T++ + P
Sbjct: 331 ATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHSWAL-MTQNSSPPWPEELDPQHLWW 389
Query: 433 DTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPS 492
+ Y+ T+F TLA F V+ F + I +P+G F+P
Sbjct: 390 EWYHPRFTIF--------------------GTLAFFLVMKFWMLILATTIPMPAGYFMPI 429
Query: 493 LLCGAAFGRLVANVLKSYIGLG--------HIYSGTFALIGAAAFLGGVVRMTISLTVIL 544
+ GAA GRL L G I G +AL GAAAF G V TIS ++
Sbjct: 430 FVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTH-TISTALLA 488
Query: 545 IESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLE--WETEVEMDKLRAS 602
E T +I + LP+++ ++ A YD V ++ +P L + ++R
Sbjct: 489 FEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVE 548
Query: 603 DIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVV 636
M ++T + ++ +V ++ +T +P+V
Sbjct: 549 HFMNHSITTLAKDMPLEEVVKVVTSTDVAKYPLV 582
>gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]
Length = 687
Score = 119 bits (299), Expect = 9e-27
Identities = 125/516 (24%), Positives = 220/516 (42%), Gaps = 76/516 (14%)
Query: 150 IEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGG--LFVGKEGPMIHSG 207
I P + GSGIPE+K L GV + + ++ KV+G+ ++A G LF+GK GP +H
Sbjct: 114 ITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLS 173
Query: 208 SVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEE 267
++ A L + ++ ++ + + + + + + A AA GVA F AP G LFS+E
Sbjct: 174 VMIAAYLGRVRTTTIGEPE-------NKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEV 226
Query: 268 GSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCH 327
SS ++ W+ F + F F+L + N + + K
Sbjct: 227 MSSHFSVRDYWRGFFAATCGAFI---------------FRLLAVFNSEQETITSLYKTSF 271
Query: 328 L----WTAMDLGFFVVMGVIGGLLGATFNCLNK------RLAKYRMRNVHPKPKLVRVLE 377
+ ++ FFV +G I G+L + + + +Y + + + L
Sbjct: 272 RVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALA 331
Query: 378 SLLVSLVT---TVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPN-- 432
+LL++ +T V F+AS + + S N S+ L +T++ + P
Sbjct: 332 TLLLASITYPPGVGHFLASRL---SMKQHLDSLFDNHSWAL-MTQNSSPPWPEELDPQHL 387
Query: 433 --DTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFV 490
+ Y+ T+F TLA F V+ F + I +P+G F+
Sbjct: 388 WWEWYHPRFTIF--------------------GTLAFFLVMKFWMLILATTIPMPAGYFM 427
Query: 491 PSLLCGAAFGRLVANVLKSYIGLG--------HIYSGTFALIGAAAFLGGVVRMTISLTV 542
P + GAA GRL+ L G I G +AL GAAAF G V TIS +
Sbjct: 428 PIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH-TISTAL 486
Query: 543 ILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLE--WETEVEMDKLR 600
+ E T +I + LP+++ ++ A YD + ++ +P L + +R
Sbjct: 487 LAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVR 546
Query: 601 ASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVV 636
M ++T + T ++ +V ++ +T +P+V
Sbjct: 547 VEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLV 582
>gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
Length = 686
Score = 119 bits (299), Expect = 9e-27
Identities = 125/516 (24%), Positives = 220/516 (42%), Gaps = 76/516 (14%)
Query: 150 IEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGG--LFVGKEGPMIHSG 207
I P + GSGIPE+K L GV + + ++ KV+G+ ++A G LF+GK GP +H
Sbjct: 114 ITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLS 173
Query: 208 SVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEE 267
++ A L + ++ ++ + + + + + + A AA GVA F AP G LFS+E
Sbjct: 174 VMIAAYLGRVRTTTIGEPE-------NKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEV 226
Query: 268 GSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCH 327
SS ++ W+ F + F F+L + N + + K
Sbjct: 227 MSSHFSVRDYWRGFFAATCGAFI---------------FRLLAVFNSEQETITSLYKTSF 271
Query: 328 L----WTAMDLGFFVVMGVIGGLLGATFNCLNK------RLAKYRMRNVHPKPKLVRVLE 377
+ ++ FFV +G I G+L + + + +Y + + + L
Sbjct: 272 RVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALA 331
Query: 378 SLLVSLVT---TVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPN-- 432
+LL++ +T V F+AS + + S N S+ L +T++ + P
Sbjct: 332 TLLLASITYPPGVGHFLASRL---SMKQHLDSLFDNHSWAL-MTQNSSPPWPEELDPQHL 387
Query: 433 --DTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFV 490
+ Y+ T+F TLA F V+ F + I +P+G F+
Sbjct: 388 WWEWYHPRFTIF--------------------GTLAFFLVMKFWMLILATTIPMPAGYFM 427
Query: 491 PSLLCGAAFGRLVANVLKSYIGLG--------HIYSGTFALIGAAAFLGGVVRMTISLTV 542
P + GAA GRL+ L G I G +AL GAAAF G V TIS +
Sbjct: 428 PIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH-TISTAL 486
Query: 543 ILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLE--WETEVEMDKLR 600
+ E T +I + LP+++ ++ A YD + ++ +P L + +R
Sbjct: 487 LAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVR 546
Query: 601 ASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVV 636
M ++T + T ++ +V ++ +T +P+V
Sbjct: 547 VEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLV 582
>gi|13654235 regulator of G-protein signaling 20 isoform b [Homo
sapiens]
Length = 241
Score = 35.8 bits (81), Expect = 0.18
Identities = 12/17 (70%), Positives = 12/17 (70%)
Query: 2 AGCRGSLCCCCRWCCCC 18
AG RGS CC WCCCC
Sbjct: 53 AGSRGSNACCFCWCCCC 69
>gi|41281805 regulator of G-protein signaling 20 isoform a [Homo
sapiens]
Length = 388
Score = 35.8 bits (81), Expect = 0.18
Identities = 12/17 (70%), Positives = 12/17 (70%)
Query: 2 AGCRGSLCCCCRWCCCC 18
AG RGS CC WCCCC
Sbjct: 200 AGSRGSNACCFCWCCCC 216
>gi|169204828 PREDICTED: hypothetical protein [Homo sapiens]
Length = 219
Score = 34.7 bits (78), Expect = 0.39
Identities = 10/15 (66%), Positives = 10/15 (66%)
Query: 4 CRGSLCCCCRWCCCC 18
C G CCCC CCCC
Sbjct: 152 CPGCCCCCCCCCCCC 166
Score = 32.0 bits (71), Expect = 2.6
Identities = 9/15 (60%), Positives = 9/15 (60%)
Query: 4 CRGSLCCCCRWCCCC 18
C CCCC WCC C
Sbjct: 158 CCCCCCCCCCWCCSC 172
>gi|169205567 PREDICTED: hypothetical protein [Homo sapiens]
Length = 219
Score = 34.7 bits (78), Expect = 0.39
Identities = 10/15 (66%), Positives = 10/15 (66%)
Query: 4 CRGSLCCCCRWCCCC 18
C G CCCC CCCC
Sbjct: 152 CPGCCCCCCCCCCCC 166
Score = 32.0 bits (71), Expect = 2.6
Identities = 9/15 (60%), Positives = 9/15 (60%)
Query: 4 CRGSLCCCCRWCCCC 18
C CCCC WCC C
Sbjct: 158 CCCCCCCCCCWCCSC 172
>gi|169204182 PREDICTED: hypothetical protein [Homo sapiens]
Length = 220
Score = 34.7 bits (78), Expect = 0.39
Identities = 10/15 (66%), Positives = 10/15 (66%)
Query: 4 CRGSLCCCCRWCCCC 18
C G CCCC CCCC
Sbjct: 152 CPGCCCCCCCCCCCC 166
Score = 32.0 bits (71), Expect = 2.6
Identities = 9/15 (60%), Positives = 9/15 (60%)
Query: 4 CRGSLCCCCRWCCCC 18
C CCCC WCC C
Sbjct: 159 CCCCCCCCCCWCCSC 173
Score = 30.4 bits (67), Expect = 7.4
Identities = 8/10 (80%), Positives = 8/10 (80%)
Query: 9 CCCCRWCCCC 18
CCCC CCCC
Sbjct: 158 CCCCCCCCCC 167
>gi|4557415 cystathionine-beta-synthase [Homo sapiens]
Length = 551
Score = 32.7 bits (73), Expect = 1.5
Identities = 15/54 (27%), Positives = 25/54 (46%)
Query: 810 SPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQARLR 863
+P TV P + R G PVV+ G I+G++T N+ L +++
Sbjct: 421 APLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQ 474
>gi|239754592 PREDICTED: hypothetical LOC100129126 [Homo sapiens]
Length = 190
Score = 31.6 bits (70), Expect = 3.3
Identities = 21/86 (24%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 732 MEERFRPLTFHGLIL-RSQLVTLLV-RGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHD 789
M E + L GL++ + L+TLL R + E++ S+ PR+ + D H
Sbjct: 1 MLENYGNLVSLGLVISKPDLITLLEQRALECEETEDSSQIPRMGRGGTVNTTSLFSDFHA 60
Query: 790 LDLTLLNPRMIVDVTPYMNPSPFTVS 815
+ +++ M++ V ++P P +S
Sbjct: 61 ITISVTQVVMLLAVVSLLSPGPMLLS 86
>gi|239749130 PREDICTED: hypothetical LOC100129126 [Homo sapiens]
Length = 190
Score = 31.6 bits (70), Expect = 3.3
Identities = 21/86 (24%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 732 MEERFRPLTFHGLIL-RSQLVTLLV-RGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHD 789
M E + L GL++ + L+TLL R + E++ S+ PR+ + D H
Sbjct: 1 MLENYGNLVSLGLVISKPDLITLLEQRALECEETEDSSQIPRMGRGGTVNTTSLFSDFHA 60
Query: 790 LDLTLLNPRMIVDVTPYMNPSPFTVS 815
+ +++ M++ V ++P P +S
Sbjct: 61 ITISVTQVVMLLAVVSLLSPGPMLLS 86
>gi|239743202 PREDICTED: hypothetical LOC100129126 [Homo sapiens]
Length = 190
Score = 31.6 bits (70), Expect = 3.3
Identities = 21/86 (24%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 732 MEERFRPLTFHGLIL-RSQLVTLLV-RGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHD 789
M E + L GL++ + L+TLL R + E++ S+ PR+ + D H
Sbjct: 1 MLENYGNLVSLGLVISKPDLITLLEQRALECEETEDSSQIPRMGRGGTVNTTSLFSDFHA 60
Query: 790 LDLTLLNPRMIVDVTPYMNPSPFTVS 815
+ +++ M++ V ++P P +S
Sbjct: 61 ITISVTQVVMLLAVVSLLSPGPMLLS 86
>gi|239508877 PREDICTED: hypothetical LOC100129126 [Homo sapiens]
Length = 190
Score = 31.6 bits (70), Expect = 3.3
Identities = 21/86 (24%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 732 MEERFRPLTFHGLIL-RSQLVTLLV-RGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHD 789
M E + L GL++ + L+TLL R + E++ S+ PR+ + D H
Sbjct: 1 MLENYGNLVSLGLVISKPDLITLLEQRALECEETEDSSQIPRMGRGGTVNTTSLFSDFHA 60
Query: 790 LDLTLLNPRMIVDVTPYMNPSPFTVS 815
+ +++ M++ V ++P P +S
Sbjct: 61 ITISVTQVVMLLAVVSLLSPGPMLLS 86
>gi|38708169 sorting nexin 25 [Homo sapiens]
Length = 840
Score = 31.6 bits (70), Expect = 3.3
Identities = 25/101 (24%), Positives = 48/101 (47%), Gaps = 3/101 (2%)
Query: 617 RIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIK--FKKSSILTRAGEQRKR 674
R Q +V I++ T +FP + ++G E MK + L + N+K + ++ + E+R R
Sbjct: 200 RYQIVVEIIQATTISSFPQLKRHKGKETAAMKADLLRARNMKRYINQLTVAKKQCEKRIR 259
Query: 675 SQSMKSYPSSELRNMCD-EHIASEEPAEKEDLLQQMLERRY 714
+Y E + + E S++ + ED+L R +
Sbjct: 260 ILGGPAYDQQEDGALDEGEGPQSQKILQFEDILANTFYREH 300
>gi|45504382 DnaJ (Hsp40) homolog, subfamily C, member 5 [Homo
sapiens]
Length = 198
Score = 31.2 bits (69), Expect = 4.4
Identities = 16/50 (32%), Positives = 25/50 (50%), Gaps = 1/50 (2%)
Query: 4 CRGSLCCCCRWCCCCGERETRTPE-ELTILGETQEEEDEILPRKDYESLD 52
C C CC + CCCG+ + + PE E T + E+ + L + E+ D
Sbjct: 119 CYCCCCLCCCFNCCCGKCKPKAPEGEETEFYVSPEDLEAQLQSDEREATD 168
>gi|29126218 DnaJ (Hsp40) homolog, subfamily C, member 5 beta [Homo
sapiens]
Length = 199
Score = 31.2 bits (69), Expect = 4.4
Identities = 18/52 (34%), Positives = 24/52 (46%), Gaps = 3/52 (5%)
Query: 1 MAGCRGSLCCCCRWCCCCG--ERETRTPEE-LTILGETQEEEDEILPRKDYE 49
+ GC C CC CCCG E+ PEE + E EE+ + KD +
Sbjct: 120 LTGCYFCCCLCCCCNCCCGHCRPESSVPEEDFYVSPEDLEEQIKSDMEKDVD 171
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,506,529
Number of Sequences: 37866
Number of extensions: 1394731
Number of successful extensions: 4947
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 4752
Number of HSP's gapped (non-prelim): 100
length of query: 869
length of database: 18,247,518
effective HSP length: 111
effective length of query: 758
effective length of database: 14,044,392
effective search space: 10645649136
effective search space used: 10645649136
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.