Search of human proteins with 4501959

Search of human proteins with 4501959

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
         (520 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]               1060   0.0  
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]                478   e-135
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    453   e-127
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    453   e-127
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    453   e-127
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    453   e-127
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa...   228   1e-59
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]   226   4e-59
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]   226   4e-59
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]    226   4e-59
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                  216   3e-56
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]               215   7e-56
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa...   211   1e-54
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   207   1e-53
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   207   2e-53
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]      204   1e-52
gi|4503383 dopamine receptor D1 [Homo sapiens]                        202   6e-52
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]         201   1e-51
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]           201   1e-51
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]            201   2e-51
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap...   194   1e-49
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]             192   8e-49
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]             187   2e-47
gi|4503391 dopamine receptor D5 [Homo sapiens]                        187   2e-47
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]            185   1e-46
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap...   179   4e-45
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi...   178   9e-45
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]         177   2e-44
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]         177   2e-44
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]         177   2e-44

>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score = 1060 bits (2741), Expect = 0.0
 Identities = 520/520 (100%), Positives = 520/520 (100%)

Query: 1   MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI 60
           MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
Sbjct: 1   MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI 60

Query: 61  VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI 120
           VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
Sbjct: 61  VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI 120

Query: 121 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP 180
           WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
Sbjct: 121 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP 180

Query: 181 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG 240
           LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
Sbjct: 181 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG 240

Query: 241 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV 300
           VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
Sbjct: 241 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV 300

Query: 301 GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV 360
           GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV
Sbjct: 301 GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV 360

Query: 361 RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT 420
           RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT
Sbjct: 361 RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT 420

Query: 421 LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT 480
           LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT
Sbjct: 421 LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT 480

Query: 481 EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF 520
           EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
Sbjct: 481 EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF 520


>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score =  478 bits (1231), Expect = e-135
 Identities = 244/422 (57%), Positives = 299/422 (70%), Gaps = 29/422 (6%)

Query: 44  RAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSA 103
           + + VG+ L AFIL A+ GN+LVILSVACNRHL+T TNYFIVNLA+ADLLLS TVLPFSA
Sbjct: 95  QGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSA 154

Query: 104 ALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAI 163
            +EVLG+W  GR FCD+WAAVDVLCCTASILSLC IS+DRY+GVR+SL+YP ++T RKA 
Sbjct: 155 TMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAA 214

Query: 164 LALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMY 223
             L  +WV++ V+S+GPLLGWKEP P D++ CG+TEE  YA+FSS+ SFY+P+AVI+VMY
Sbjct: 215 AILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMY 274

Query: 224 CRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNF---HEDTLSSTKAKGHNPRSSIA 280
           CRVY+VA+ TT++LEAGV +E   + E+ LRIH +      +       AKGH  RSS++
Sbjct: 275 CRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLS 334

Query: 281 VKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFN 340
           V+L KFSREKKAAKTL IVVG+F+LCW PFF  LPLGSLF  LKP + VFKV+FWLGYFN
Sbjct: 335 VRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFN 394

Query: 341 SCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERS 400
           SC+NP+IYPCSS+EFKRAF+R+L CQC     RRRRRRR L      +R +        S
Sbjct: 395 SCVNPLIYPCSSREFKRAFLRLLRCQC-----RRRRRRRPL------WRVYGHHWRASTS 443

Query: 401 QSRKDSLDDSGSCLSGSQ---RTLPSASPSP--------GYLGRGAPPPVELCAFPEWKA 449
             R+D    SG    G+      LP   P P            R  PP     AF EW+ 
Sbjct: 444 GLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPP----SAFREWRL 499

Query: 450 PG 451
            G
Sbjct: 500 LG 501


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  453 bits (1166), Expect = e-127
 Identities = 223/369 (60%), Positives = 283/369 (76%), Gaps = 15/369 (4%)

Query: 26  TGPNQTSSNSTLPQ--LDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYF 83
           +G    SSN T P   ++I++AI +G++LG  ILF ++GNILVILSVAC+RHL + T+Y+
Sbjct: 5   SGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYY 64

Query: 84  IVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDR 143
           IVNLA+ADLLL+ TVLPFSA  EVLGYW  GR+FC+IWAAVDVLCCTASI+ LC ISIDR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 144 YIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFY 203
           YIGV Y L+YPT+VT+R+ ++ALL VW LS VISIGPL GW++PAP D+  C + EEP Y
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY 184

Query: 204 ALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHE- 262
            LFS+LGSFY+PLA+ILVMYCRVY+VAKR ++ L++G+  + S+S+++TLRIH KN    
Sbjct: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAG 244

Query: 263 -DTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFS 321
              ++S K K H      +V+L KFSREKKAAKTLGIVVG F+LCWLPFF+ +P+GS F 
Sbjct: 245 GSGMASAKTKTH-----FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP 299

Query: 322 TLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRL 381
             KP + VFK+VFWLGY NSC+NPIIYPCSS+EFK+AF  +L  QC     R++  +  L
Sbjct: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCL---CRKQSSKHAL 356

Query: 382 GGCAYTYRP 390
           G   YT  P
Sbjct: 357 G---YTLHP 362


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  453 bits (1166), Expect = e-127
 Identities = 223/369 (60%), Positives = 283/369 (76%), Gaps = 15/369 (4%)

Query: 26  TGPNQTSSNSTLPQ--LDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYF 83
           +G    SSN T P   ++I++AI +G++LG  ILF ++GNILVILSVAC+RHL + T+Y+
Sbjct: 5   SGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYY 64

Query: 84  IVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDR 143
           IVNLA+ADLLL+ TVLPFSA  EVLGYW  GR+FC+IWAAVDVLCCTASI+ LC ISIDR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 144 YIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFY 203
           YIGV Y L+YPT+VT+R+ ++ALL VW LS VISIGPL GW++PAP D+  C + EEP Y
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY 184

Query: 204 ALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHE- 262
            LFS+LGSFY+PLA+ILVMYCRVY+VAKR ++ L++G+  + S+S+++TLRIH KN    
Sbjct: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAG 244

Query: 263 -DTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFS 321
              ++S K K H      +V+L KFSREKKAAKTLGIVVG F+LCWLPFF+ +P+GS F 
Sbjct: 245 GSGMASAKTKTH-----FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP 299

Query: 322 TLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRL 381
             KP + VFK+VFWLGY NSC+NPIIYPCSS+EFK+AF  +L  QC     R++  +  L
Sbjct: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCL---CRKQSSKHAL 356

Query: 382 GGCAYTYRP 390
           G   YT  P
Sbjct: 357 G---YTLHP 362


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  453 bits (1166), Expect = e-127
 Identities = 223/369 (60%), Positives = 283/369 (76%), Gaps = 15/369 (4%)

Query: 26  TGPNQTSSNSTLPQ--LDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYF 83
           +G    SSN T P   ++I++AI +G++LG  ILF ++GNILVILSVAC+RHL + T+Y+
Sbjct: 5   SGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYY 64

Query: 84  IVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDR 143
           IVNLA+ADLLL+ TVLPFSA  EVLGYW  GR+FC+IWAAVDVLCCTASI+ LC ISIDR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 144 YIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFY 203
           YIGV Y L+YPT+VT+R+ ++ALL VW LS VISIGPL GW++PAP D+  C + EEP Y
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY 184

Query: 204 ALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHE- 262
            LFS+LGSFY+PLA+ILVMYCRVY+VAKR ++ L++G+  + S+S+++TLRIH KN    
Sbjct: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAG 244

Query: 263 -DTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFS 321
              ++S K K H      +V+L KFSREKKAAKTLGIVVG F+LCWLPFF+ +P+GS F 
Sbjct: 245 GSGMASAKTKTH-----FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP 299

Query: 322 TLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRL 381
             KP + VFK+VFWLGY NSC+NPIIYPCSS+EFK+AF  +L  QC     R++  +  L
Sbjct: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCL---CRKQSSKHAL 356

Query: 382 GGCAYTYRP 390
           G   YT  P
Sbjct: 357 G---YTLHP 362


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  453 bits (1166), Expect = e-127
 Identities = 223/369 (60%), Positives = 283/369 (76%), Gaps = 15/369 (4%)

Query: 26  TGPNQTSSNSTLPQ--LDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYF 83
           +G    SSN T P   ++I++AI +G++LG  ILF ++GNILVILSVAC+RHL + T+Y+
Sbjct: 5   SGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYY 64

Query: 84  IVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDR 143
           IVNLA+ADLLL+ TVLPFSA  EVLGYW  GR+FC+IWAAVDVLCCTASI+ LC ISIDR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 144 YIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFY 203
           YIGV Y L+YPT+VT+R+ ++ALL VW LS VISIGPL GW++PAP D+  C + EEP Y
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY 184

Query: 204 ALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHE- 262
            LFS+LGSFY+PLA+ILVMYCRVY+VAKR ++ L++G+  + S+S+++TLRIH KN    
Sbjct: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAG 244

Query: 263 -DTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFS 321
              ++S K K H      +V+L KFSREKKAAKTLGIVVG F+LCWLPFF+ +P+GS F 
Sbjct: 245 GSGMASAKTKTH-----FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP 299

Query: 322 TLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRL 381
             KP + VFK+VFWLGY NSC+NPIIYPCSS+EFK+AF  +L  QC     R++  +  L
Sbjct: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCL---CRKQSSKHAL 356

Query: 382 GGCAYTYRP 390
           G   YT  P
Sbjct: 357 G---YTLHP 362


>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
           sapiens]
          Length = 422

 Score =  228 bits (580), Expect = 1e-59
 Identities = 137/424 (32%), Positives = 220/424 (51%), Gaps = 74/424 (17%)

Query: 8   GHNTSAPAHWGELKNANFTGPNQTSSNST-LPQLDITRAISVGLVLGAFILFAIVGNILV 66
           G+NT++P             P +T  N+T +  + ++  +   L+LG  I  A++GN  V
Sbjct: 9   GNNTTSPP-----------APFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACV 57

Query: 67  ILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDV 126
           + ++A  R L+   NY I +LA+ DL++S  VLP +A  +VL  W LG++ CD++ A+DV
Sbjct: 58  VAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDV 117

Query: 127 LCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKE 186
           LCCT+SIL LCAI++DRY  +   + Y    T R+A   +   W++  +ISI P+LGW+ 
Sbjct: 118 LCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRT 177

Query: 187 PAPNDDKE-CGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVA----KRTTKNLEA-- 239
           P    D + C ++++  Y ++S+ G+FYIPL ++LV+Y R++  A    ++T K +E   
Sbjct: 178 PEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTG 237

Query: 240 -----------------------------------------GVMKEMSNSKEL-TLRIHS 257
                                                    G +++  +   L  + +H 
Sbjct: 238 ADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHR 297

Query: 258 KNFHEDTLSSTKAKGHNP-----------RSSIAVKLFKFSREKKAAKTLGIVVGMFILC 306
               ++ L      G  P           R++ A +    +RE+K  KTLGI++G FILC
Sbjct: 298 VGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILC 357

Query: 307 WLPFFI-ALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGC 365
           WLPFFI AL L    S+   P  +  ++ WLGY NS LNP+IY   +K+F+ AF +I+ C
Sbjct: 358 WLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKC 417

Query: 366 Q-CR 368
           + CR
Sbjct: 418 KFCR 421


>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
          Length = 432

 Score =  226 bits (576), Expect = 4e-59
 Identities = 124/341 (36%), Positives = 197/341 (57%), Gaps = 26/341 (7%)

Query: 46  ISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAAL 105
           + +G +L    L  I GN LV++SV   + LR P+NY IV+LA+ADL ++  V+PF +  
Sbjct: 82  VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141

Query: 106 EVLG-YWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAIL 164
           +++G  W+ G  FC+++ A+DV+CCTASI++LC ISIDRY+G+   L YP     +    
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201

Query: 165 ALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYC 224
            +LSVW+LS  I++ PL GW +   NDDK C ++++  Y ++S+  +FYIP++V+L MY 
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260

Query: 225 RVYIVAKRTTKNLEAGVMKEMSNSKELTLR--IHSKNFHEDTLSSTKAKGHNPRSSIAVK 282
           ++Y  A+++    +      +     + L   +  +   E+  + ++   H  R +I++ 
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHE-RKNISI- 318

Query: 283 LFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKP----------PDAVFKV 332
              F RE+KAA TLGI+VG F +CWLPFF       L ST +P          P  V + 
Sbjct: 319 ---FKREQKAATTLGIIVGAFTVCWLPFF-------LLSTARPFICGTSCSCIPLWVERT 368

Query: 333 VFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRR 373
             WLGY NS +NP IY   +++ +  +  +L CQ R   R+
Sbjct: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRK 409


>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
          Length = 479

 Score =  226 bits (576), Expect = 4e-59
 Identities = 124/341 (36%), Positives = 197/341 (57%), Gaps = 26/341 (7%)

Query: 46  ISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAAL 105
           + +G +L    L  I GN LV++SV   + LR P+NY IV+LA+ADL ++  V+PF +  
Sbjct: 82  VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141

Query: 106 EVLG-YWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAIL 164
           +++G  W+ G  FC+++ A+DV+CCTASI++LC ISIDRY+G+   L YP     +    
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201

Query: 165 ALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYC 224
            +LSVW+LS  I++ PL GW +   NDDK C ++++  Y ++S+  +FYIP++V+L MY 
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260

Query: 225 RVYIVAKRTTKNLEAGVMKEMSNSKELTLR--IHSKNFHEDTLSSTKAKGHNPRSSIAVK 282
           ++Y  A+++    +      +     + L   +  +   E+  + ++   H  R +I++ 
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHE-RKNISI- 318

Query: 283 LFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKP----------PDAVFKV 332
              F RE+KAA TLGI+VG F +CWLPFF       L ST +P          P  V + 
Sbjct: 319 ---FKREQKAATTLGIIVGAFTVCWLPFF-------LLSTARPFICGTSCSCIPLWVERT 368

Query: 333 VFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRR 373
             WLGY NS +NP IY   +++ +  +  +L CQ R   R+
Sbjct: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRK 409


>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
          Length = 445

 Score =  226 bits (576), Expect = 4e-59
 Identities = 124/341 (36%), Positives = 197/341 (57%), Gaps = 26/341 (7%)

Query: 46  ISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAAL 105
           + +G +L    L  I GN LV++SV   + LR P+NY IV+LA+ADL ++  V+PF +  
Sbjct: 82  VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141

Query: 106 EVLG-YWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAIL 164
           +++G  W+ G  FC+++ A+DV+CCTASI++LC ISIDRY+G+   L YP     +    
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201

Query: 165 ALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYC 224
            +LSVW+LS  I++ PL GW +   NDDK C ++++  Y ++S+  +FYIP++V+L MY 
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260

Query: 225 RVYIVAKRTTKNLEAGVMKEMSNSKELTLR--IHSKNFHEDTLSSTKAKGHNPRSSIAVK 282
           ++Y  A+++    +      +     + L   +  +   E+  + ++   H  R +I++ 
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHE-RKNISI- 318

Query: 283 LFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKP----------PDAVFKV 332
              F RE+KAA TLGI+VG F +CWLPFF       L ST +P          P  V + 
Sbjct: 319 ---FKREQKAATTLGIIVGAFTVCWLPFF-------LLSTARPFICGTSCSCIPLWVERT 368

Query: 333 VFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRR 373
             WLGY NS +NP IY   +++ +  +  +L CQ R   R+
Sbjct: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRK 409


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score =  216 bits (551), Expect = 3e-56
 Identities = 131/362 (36%), Positives = 198/362 (54%), Gaps = 33/362 (9%)

Query: 48  VGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEV 107
           +GL++   +L  + GN+LVI+++A    L+T TN FI++LA ADL++   V+PF A + V
Sbjct: 61  MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV 120

Query: 108 LGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALL 167
            G W  G  FC++W +VDVLC TASI +LC I++DRY+ +    +Y +L+TR +A   + 
Sbjct: 121 WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC 180

Query: 168 SVWVLSTVISIGPLL--GWKEPAP------NDDKECGVTEEPFYALFSSLGSFYIPLAVI 219
           +VW +S ++S  P+L   W+  +       ND K C       YA+ SS+ SFY+PL ++
Sbjct: 181 TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM 240

Query: 220 LVMYCRVYIVAKRTTKNLEA-------GVMKEMSNSKELTLR--------IHSKNFHEDT 264
             +Y RV+  A++  K +++       G  +  S S                +       
Sbjct: 241 AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP 300

Query: 265 LSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLK 324
           L++ +A    P   +A+      RE+KA KTLGI++G+F LCWLPFF+A  + +    L 
Sbjct: 301 LANGRAGKRRPSRLVAL------REQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL- 353

Query: 325 PPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRR--RRRLG 382
            PD +F    WLGY NS  NPIIY C S +F++AF  +L C  R   RR      R R  
Sbjct: 354 VPDRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLLCCARRAARRRHATHGDRPRAS 412

Query: 383 GC 384
           GC
Sbjct: 413 GC 414


>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
          Length = 408

 Score =  215 bits (548), Expect = 7e-56
 Identities = 137/374 (36%), Positives = 205/374 (54%), Gaps = 22/374 (5%)

Query: 9   HNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVIL 68
           H  S+ A W +L       PN T++ S LP +    A++ G +L   +L  + GN+LVI+
Sbjct: 6   HENSSLAPWPDLPTL---APN-TANTSGLPGVPWEAALA-GALLALAVLATVGGNLLVIV 60

Query: 69  SVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLC 128
           ++A    L+T TN F+ +LA ADL++   V+P +A L + G+W LG   C++W +VDVLC
Sbjct: 61  AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC 120

Query: 129 CTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLG--WKE 186
            TASI +LCA+++DRY+ V   L+Y  LVT+R A  A++ VWV+S  +S  P++   W+ 
Sbjct: 121 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV 180

Query: 187 PAP-------NDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEA 239
            A        ++ + C       Y L SS  SFY+PL V+L +Y RV++VA R  + L  
Sbjct: 181 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG 240

Query: 240 GVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIV 299
            + +      E +    S++     + +       P            RE +A  TLG++
Sbjct: 241 ELGR---FPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLI 297

Query: 300 VGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAF 359
           +G F LCWLPFF+A  L +L      P   F  + WLGY NS  NP+IY C S +F+ AF
Sbjct: 298 MGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIY-CRSPDFRSAF 356

Query: 360 VRILGCQCRGRGRR 373
            R+L C+C   GRR
Sbjct: 357 RRLL-CRC---GRR 366


>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
           sapiens]
          Length = 366

 Score =  211 bits (538), Expect = 1e-54
 Identities = 120/363 (33%), Positives = 195/363 (53%), Gaps = 25/363 (6%)

Query: 29  NQTSSNSTLPQL--DITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVN 86
           N +  N T  +L   +   I V L L    L     N LVI ++   R L  P NY I +
Sbjct: 5   NSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICS 64

Query: 87  LAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIG 146
           LA+ D L++  V+PFS    V   W++G++ CDIW +VD+ CCT SIL L AI++DRY  
Sbjct: 65  LAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRA 124

Query: 147 VRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYA-L 205
           +  +++Y    T + A + +  VW++S  IS+ PL  W+    + D EC +  +   + +
Sbjct: 125 ITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF-WRHQGTSRDDECIIKHDHIVSTI 183

Query: 206 FSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG-VMKEMSNSKEL-------TLRIHS 257
           +S+ G+FYIPLA+IL++Y ++Y  AK      +A  + KE  N + L       T  + +
Sbjct: 184 YSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVST 243

Query: 258 KNFHEDTLSSTKAKGHNPRSSIAVKLFKF-------------SREKKAAKTLGIVVGMFI 304
               E +LS          S++     +F             +RE+KAA TLG+++G F+
Sbjct: 244 SYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFV 303

Query: 305 LCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILG 364
           +CWLPFF+   + ++    K  + +   + WLGY NS +NP+IY   +++FK+AF +++ 
Sbjct: 304 ICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVR 363

Query: 365 CQC 367
           C+C
Sbjct: 364 CRC 366


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  207 bits (528), Expect = 1e-53
 Identities = 127/372 (34%), Positives = 195/372 (52%), Gaps = 35/372 (9%)

Query: 22  NANFTGPNQTSSNSTLPQLDITRA----------ISVGLVLGAFILFAIVGNILVILSVA 71
           N +  G  Q +SN +L   + + A          IS+ +VL    L  ++ N  V+ ++ 
Sbjct: 5   NQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTIL 64

Query: 72  CNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTA 131
             R L TP NY I +LA  DLL+S  V+P S A  +   W  G+I CDIW + D+ CCTA
Sbjct: 65  LTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTA 124

Query: 132 SILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPND 191
           SIL LC I++DRY  +  +L+Y    T   A   +  VW +S  ISI PL   +  A  +
Sbjct: 125 SILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEE 184

Query: 192 DKECGV-TEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKE 250
             +C V T +  Y ++S+ G+FYIP  +++++Y R+Y  A+    N  +   K  + +  
Sbjct: 185 MSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHL 244

Query: 251 LTLRIHSKNFHEDTLSSTKAKGHN----------------PRSSIAVKLFKFSREKKAAK 294
           +T    S      +L+S+  +GH+                  S++  K    +RE+KA K
Sbjct: 245 IT---GSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATK 301

Query: 295 TLGIVVGMFILCWLPFFI---ALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCS 351
            LGI++G FI+CWLPFF+    LP+      + P  A+F    WLGY NS +NPIIY   
Sbjct: 302 ILGIILGAFIICWLPFFVVSLVLPICRDSCWIHP--ALFDFFTWLGYLNSLINPIIYTVF 359

Query: 352 SKEFKRAFVRIL 363
           ++EF++AF +I+
Sbjct: 360 NEEFRQAFQKIV 371


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  207 bits (527), Expect = 2e-53
 Identities = 121/335 (36%), Positives = 185/335 (55%), Gaps = 17/335 (5%)

Query: 50  LVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLG 109
           ++L    L   + N  VI +V   R L TP NY I +LA+ DLL+S  V+P S    V G
Sbjct: 54  MLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTG 113

Query: 110 YWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSV 169
            W LG++ CD W + D+ CCTASIL LC I++DRY  +  +++Y    T ++A + +  V
Sbjct: 114 RWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALV 173

Query: 170 WVLSTVISIGPLLGWKEPAPNDDKECGV-TEEPFYALFSSLGSFYIPLAVILVMYCRVYI 228
           WV S  IS+ P    +  A  +  EC V T+   Y ++S++G+FY P  +++ +Y R+Y+
Sbjct: 174 WVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYV 233

Query: 229 VAK---------RTTKNL-EAGVMKEMSNSKELTLRIHSK--NFHEDTLSSTKAKGHNPR 276
            A+         RT K L  A ++ +   S      I+S+  +   ++ S         R
Sbjct: 234 EARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVR 293

Query: 277 SSIAV---KLFKFSREKKAAKTLGIVVGMFILCWLPFF-IALPLGSLFSTLKPPDAVFKV 332
            S A+   K    +RE+KA KTLGI++G FI+CWLPFF I+L +           A+F  
Sbjct: 294 VSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDF 353

Query: 333 VFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQC 367
             WLGY NS +NPIIY  S+++FK+AF +++  +C
Sbjct: 354 FTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKC 388


>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
          Length = 413

 Score =  204 bits (520), Expect = 1e-52
 Identities = 122/355 (34%), Positives = 189/355 (53%), Gaps = 35/355 (9%)

Query: 22  NANFTGPNQTSS--NSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTP 79
           +A    PN++ +  +    Q D    + +G+V+   +L  + GN+LVI ++A    L+T 
Sbjct: 8   SAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTV 67

Query: 80  TNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAI 139
           TNYFI +LA ADL++   V+PF AA  ++  W  G  +C+ W ++DVLC TASI +LC I
Sbjct: 68  TNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVI 127

Query: 140 SIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPL-LGWKEPAPNDDKECGVT 198
           ++DRY  +    +Y +L+T+ KA + +L VW++S + S  P+ + W      +   C   
Sbjct: 128 AVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAN 187

Query: 199 E-------EPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKEL 251
           E          YA+ SS+ SFY+PL +++ +Y RV+  AKR  + ++             
Sbjct: 188 ETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKS----------- 236

Query: 252 TLRIHSKNFHEDTLSSTK---AKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWL 308
                   FH   LS  +     GH  R S    L    +E KA KTLGI++G F LCWL
Sbjct: 237 -----EGRFHVQNLSQVEQDGRTGHGLRRSSKFCL----KEHKALKTLGIIMGTFTLCWL 287

Query: 309 PFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRIL 363
           PFFI   +  +   L   + V+ ++ W+GY NS  NP+IY C S +F+ AF  +L
Sbjct: 288 PFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL 340


>gi|4503383 dopamine receptor D1 [Homo sapiens]
          Length = 446

 Score =  202 bits (514), Expect = 6e-52
 Identities = 124/345 (35%), Positives = 190/345 (55%), Gaps = 36/345 (10%)

Query: 41  DITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTP-TNYFIVNLAMADLLLSFTVL 99
           D +  I     L   IL  ++GN LV  +V   RHLR+  TN+F+++LA++DLL++  V+
Sbjct: 19  DFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVM 78

Query: 100 PFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTR 159
           P+ A  E+ G+W  G  FC+IW A D++C TASIL+LC IS+DRY  +    +Y   +T 
Sbjct: 79  PWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 137

Query: 160 RKAILALLSVWVLSTVISIGPL-LGW---KEPAPNDDK---------ECGVTEEPFYALF 206
           + A + +   W LS +IS  P+ L W   K  +P+D            C  +    YA+ 
Sbjct: 138 KAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAIS 197

Query: 207 SSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLS 266
           SS+ SFYIP+A+++V Y R+Y +A++  + + A  ++  +        +H+KN    T +
Sbjct: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAA--LERAA--------VHAKNCQTTTGN 247

Query: 267 STKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFI---ALPLGSLFSTL 323
               +   P SS  +    F RE K  KTL +++G+F+ CWLPFFI    LP      T 
Sbjct: 248 GKPVECSQPESSFKM---SFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGET- 303

Query: 324 KP---PDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGC 365
           +P       F V  W G+ NS LNPIIY  ++ +F++AF  +LGC
Sbjct: 304 QPFCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGC 347


>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
          Length = 414

 Score =  201 bits (511), Expect = 1e-51
 Identities = 127/380 (33%), Positives = 192/380 (50%), Gaps = 70/380 (18%)

Query: 51  VLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGY 110
           +L   I   + GN+LV ++V+  + L+T TNY IV+LA+ADLL++  V+P+   LEV+G 
Sbjct: 40  LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99

Query: 111 WVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLS-V 169
           W   RI CDI+  +DV+ CTASIL+LCAISIDRY  V   + Y T  + ++ +  ++S V
Sbjct: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159

Query: 170 WVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIV 229
           WVLS  IS   L G       D  EC +   P + ++SS+ SFY+P  V L++Y ++YIV
Sbjct: 160 WVLSFTISCPLLFGLNNA---DQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIV 215

Query: 230 AKRTTK-------------NLEAGVMKEMSNSKELTLRI--------------------- 255
            +R  K             +L A + +    ++EL + +                     
Sbjct: 216 LRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQ 275

Query: 256 --------HSKNFHEDTLSSTKAKGHNPRSSIAVKLFKF--------------------- 286
                   H  +   D+ +  +  GH        K+F+                      
Sbjct: 276 LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLS 335

Query: 287 -SREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNP 345
             +EKKA + L IV+G+FI+CWLPFFI   L ++      P  ++    WLGY NS +NP
Sbjct: 336 QQKEKKATQMLAIVLGVFIICWLPFFITHIL-NIHCDCNIPPVLYSAFTWLGYVNSAVNP 394

Query: 346 IIYPCSSKEFKRAFVRILGC 365
           IIY   + EF++AF++IL C
Sbjct: 395 IIYTTFNIEFRKAFLKILHC 414


>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
          Length = 397

 Score =  201 bits (511), Expect = 1e-51
 Identities = 134/419 (31%), Positives = 205/419 (48%), Gaps = 74/419 (17%)

Query: 28  PNQTSSNSTLPQLDITRA-ISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVN 86
           PN T+S+  L   D T   I++ +VL   IL  + GN++V L+V  NR LR  TN FIV+
Sbjct: 3   PNGTASSFCL---DSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVS 59

Query: 87  LAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIG 146
           LA+ DLLL   VLPFSA  ++   W  G++FC+I+ ++DV+ CTASIL+L  IS+DRY  
Sbjct: 60  LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA 119

Query: 147 VRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPL-LGWK-----EPAPNDDKECGVTEE 200
           V   L+YP LVT  +  ++L+ +WV+S  +S   + LGW          +   +C V   
Sbjct: 120 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVN 179

Query: 201 PFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNF 260
             Y L   L +FY+PL ++ + Y R++ VA+   K +       +S+ K  T+R H    
Sbjct: 180 EVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRI-----NHISSWKAATIREH---- 230

Query: 261 HEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLF 320
                                         KA  TL  V+G FI+CW P+F A     ++
Sbjct: 231 ------------------------------KATVTLAAVMGAFIICWFPYFTAF----VY 256

Query: 321 STLKPPDAVFKV----VFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRR 376
             L+  DA+ +V    V WLGY NS LNPI+Y   +++F+  + ++  C+   R   +  
Sbjct: 257 RGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTS 316

Query: 377 RRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSG----SCLSGSQRTLPSASPSPGYL 431
            R             +    L R+QSR+    +         SG++ T P  +    +L
Sbjct: 317 LR-------------SNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRPWL 362


>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
          Length = 359

 Score =  201 bits (510), Expect = 2e-51
 Identities = 129/388 (33%), Positives = 195/388 (50%), Gaps = 70/388 (18%)

Query: 28  PNQTSSNSTLPQLDITRA-ISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVN 86
           PN T+S+  L   D T   I++ +VL   IL  + GN++V L+V  NR LR  TN FIV+
Sbjct: 3   PNGTASSFCL---DSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVS 59

Query: 87  LAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIG 146
           LA+ DLLL   VLPFSA  ++   W  G++FC+I+ ++DV+ CTASIL+L  IS+DRY  
Sbjct: 60  LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA 119

Query: 147 VRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPL-LGWK-----EPAPNDDKECGVTEE 200
           V   L+YP LVT  +  ++L+ +WV+S  +S   + LGW          +   +C V   
Sbjct: 120 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVN 179

Query: 201 PFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNF 260
             Y L   L +FY+PL ++ + Y R++ VA+   K +       +S+ K  T+R H    
Sbjct: 180 EVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRI-----NHISSWKAATIREH---- 230

Query: 261 HEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLF 320
                                         KA  TL  V+G FI+CW P+F A     ++
Sbjct: 231 ------------------------------KATVTLAAVMGAFIICWFPYFTAF----VY 256

Query: 321 STLKPPDAVFKV----VFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRR 376
             L+  DA+ +V    V WLGY NS LNPI+Y   +++F+  + ++  C+   R   +  
Sbjct: 257 RGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTS 316

Query: 377 RRRRLGGCAYTYRPWTRGGSLERSQSRK 404
            R             +    L R+QSR+
Sbjct: 317 LR-------------SNASQLSRTQSRE 331


>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
           sapiens]
          Length = 365

 Score =  194 bits (494), Expect = 1e-49
 Identities = 120/366 (32%), Positives = 196/366 (53%), Gaps = 41/366 (11%)

Query: 31  TSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMA 90
           T ++  +    IT  + + + L        + N+ VI+++   + L  P NY I +LA+ 
Sbjct: 8   TEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVT 67

Query: 91  DLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYS 150
           DLL++  V+P S    V+  W LG   C++W +VD+ CCT SIL LC I++DRY  +  +
Sbjct: 68  DLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNA 127

Query: 151 LQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWK-----EPAPNDDKECGVT-EEPFYA 204
           ++Y    T ++A L +L+VW +S  IS+ PL  W+      P P+   +C +  +   Y 
Sbjct: 128 IEYARKRTAKRAALMILTVWTISIFISMPPLF-WRSHRRLSPPPS---QCTIQHDHVIYT 183

Query: 205 LFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSN----------SKELTLR 254
           ++S+LG+FYIPL +IL++Y R+Y  AK   +  + G  + +SN          S +LT  
Sbjct: 184 IYSTLGAFYIPLTLILILYYRIYHAAKSLYQ--KRGSSRHLSNRSTDSQNSFASCKLTQT 241

Query: 255 IHSKNFHEDTLSSTKAKGHNPRSSIAVKLF-------------KFSREKKAAKTLGIVVG 301
               +F     ++   K H   +SI +  F               +RE+KAA+ LG+++G
Sbjct: 242 FCVSDFSTSDPTTEFEKFH---ASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILG 298

Query: 302 MFILCWLPFFI-ALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV 360
            FIL WLPFFI  L +G    T+    A F  + WLGY NS +NP++Y   +++FK AF 
Sbjct: 299 AFILSWLPFFIKELIVGLSIYTVSSEVADF--LTWLGYVNSLINPLLYTSFNEDFKLAFK 356

Query: 361 RILGCQ 366
           +++ C+
Sbjct: 357 KLIRCR 362


>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
          Length = 367

 Score =  192 bits (487), Expect = 8e-49
 Identities = 119/333 (35%), Positives = 181/333 (54%), Gaps = 24/333 (7%)

Query: 54  AFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLG-YWV 112
           A IL  + GN LV ++V   R L+T TNY +V+LA+ADLL++  V+P+   LEV G  W 
Sbjct: 38  ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97

Query: 113 LGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTR---RKAILALLSV 169
             RI CD++  +DV+ CTASIL+LCAISIDRY  V   + Y     +   R+  L + +V
Sbjct: 98  FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAV 157

Query: 170 WVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIV 229
           WVL+  +S   L G+      D   C ++  P + ++SS+ SFY+P  V +++Y R+Y+V
Sbjct: 158 WVLAFAVSCPLLFGFN--TTGDPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVV 214

Query: 230 AKR-------TTKNLEAGVMKEMSNSKELT---LRIHSKNFH---EDTL----SSTKAKG 272
            K+       T +N +   ++     + L+     +  K ++   +DT        +  G
Sbjct: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274

Query: 273 HNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKV 332
              R           REKKA + + IV+G FI+CWLPFF+   L +   T      ++  
Sbjct: 275 ELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA 334

Query: 333 VFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGC 365
             WLGY NS LNP+IY   + EF++AF++IL C
Sbjct: 335 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367


>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
          Length = 400

 Score =  187 bits (476), Expect = 2e-47
 Identities = 125/366 (34%), Positives = 188/366 (51%), Gaps = 57/366 (15%)

Query: 54  AFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLG-YWV 112
           A IL  + GN LV ++V   R L+T TNY +V+LA+ADLL++  V+P+   LEV G  W 
Sbjct: 38  ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97

Query: 113 LGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTR---RKAILALLSV 169
             RI CD++  +DV+ CTASIL+LCAISIDRY  V   + Y     +   R+  L + +V
Sbjct: 98  FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAV 157

Query: 170 WVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIV 229
           WVL+  +S   L G+      D   C ++  P + ++SS+ SFY+P  V +++Y R+Y+V
Sbjct: 158 WVLAFAVSCPLLFGFN--TTGDPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVV 214

Query: 230 AKR-------TTKNLEAGVMKEMSNSKELT---LRIHSKNFH---EDT------------ 264
            K+       T +N +   ++     + L+     +  K ++   +DT            
Sbjct: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274

Query: 265 -------------------LSSTKAKGHNPRSSIAVKLFKFS------REKKAAKTLGIV 299
                              LS    K  N R S ++KL          REKKA + + IV
Sbjct: 275 ELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIV 334

Query: 300 VGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAF 359
           +G FI+CWLPFF+   L +   T      ++    WLGY NS LNP+IY   + EF++AF
Sbjct: 335 LGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAF 394

Query: 360 VRILGC 365
           ++IL C
Sbjct: 395 LKILSC 400


>gi|4503391 dopamine receptor D5 [Homo sapiens]
          Length = 477

 Score =  187 bits (475), Expect = 2e-47
 Identities = 123/374 (32%), Positives = 194/374 (51%), Gaps = 60/374 (16%)

Query: 29  NQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTP-TNYFIVNL 87
           N    ++  P L  ++ ++  L L   I++ ++GN+LV  ++  +RHLR   TN FIV+L
Sbjct: 25  NAVGGSAGAPPLGPSQVVTACL-LTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSL 83

Query: 88  AMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGV 147
           A++DL ++  V+P+ A  EV GYW  G  FCD+W A D++C TASIL+LC IS+DRY  +
Sbjct: 84  AVSDLFVALLVMPWKAVAEVAGYWPFGA-FCDVWVAFDIMCSTASILNLCVISVDRYWAI 142

Query: 148 RYSLQYPTLVTRRKAILALLSVWVLSTVISIGPL-LGWKE---------PAPNDDKECGV 197
               +Y   +T+R A++ +   W LS +IS  P+ L W             PN+      
Sbjct: 143 SRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTP 202

Query: 198 TEEPF-----------------YALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG 240
            EE F                 YA+ SSL SFYIP+A+++V Y R+Y +A+   + + + 
Sbjct: 203 WEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISS- 261

Query: 241 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV 300
               +  + E          H  +  S+ A    P +S+   +    +E K  KTL +++
Sbjct: 262 ----LERAAE----------HAQSCRSSAACA--PDTSLRASI---KKETKVLKTLSVIM 302

Query: 301 GMFILCWLPFFI---ALPLGSLFSTLKP------PDAVFKVVFWLGYFNSCLNPIIYPCS 351
           G+F+ CWLPFFI    +P  S      P       +  F V  W G+ NS LNP+IY  +
Sbjct: 303 GVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFN 362

Query: 352 SKEFKRAFVRILGC 365
           + +F++ F ++LGC
Sbjct: 363 A-DFQKVFAQLLGC 375


>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
          Length = 357

 Score =  185 bits (469), Expect = 1e-46
 Identities = 115/352 (32%), Positives = 192/352 (54%), Gaps = 21/352 (5%)

Query: 20  LKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI--------VGNILVILSVA 71
           L + + + P+   +N +L + D+  +  +  V G  IL  +          N+LV+ ++ 
Sbjct: 7   LTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATIL 66

Query: 72  CNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGY-WVLGRIFCDIWAAVDVLCCT 130
             R      +  + ++A++D+L++  V+P S   E+ G  W LGR  C +W A DVLCCT
Sbjct: 67  RVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCT 126

Query: 131 ASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSV-WVLSTVISIGPLL-GWKEPA 188
           ASI ++ AI++DRY  +   ++Y TL TR+     ++++ W LS VIS+ PLL GW E  
Sbjct: 127 ASIWNVTAIALDRYWSITRHMEY-TLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETY 185

Query: 189 PNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNS 248
               +EC V+ EP YA+FS++G+FY+PL V+L +Y ++Y  AK    + +   +  +S +
Sbjct: 186 SEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEA 245

Query: 249 KELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWL 308
            E+               +T      P        ++  +E++AA  +GI++G+F+LCW+
Sbjct: 246 VEVKDSAKQPQMVFTVRHATVT--FQPEGD----TWREQKEQRAALMVGILIGVFVLCWI 299

Query: 309 PFFIALPLGSLFSTLKPPDAVFKVVF-WLGYFNSCLNPIIYPCSSKEFKRAF 359
           PFF+   +  L S   P  A++K +F WLGY NS  NP+IY   +K +  AF
Sbjct: 300 PFFLTELISPLCSCDIP--AIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349


>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
           sapiens]
          Length = 458

 Score =  179 bits (455), Expect = 4e-45
 Identities = 114/351 (32%), Positives = 184/351 (52%), Gaps = 22/351 (6%)

Query: 56  ILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGY-WVLG 114
           I+  I GNILVI++V+  + L   TNYF+++LA+AD+L+   V+P S    +  Y W L 
Sbjct: 64  IIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLP 123

Query: 115 RIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLST 174
           R  C +W ++DVL  TASI+ LCAIS+DRY+ +R  +++    +R KAI+ +  VW +S 
Sbjct: 124 RYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISI 183

Query: 175 VISIG-PLLGWK--EPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAK 231
            +S+  P++G +  E    ++  C V  +P + L  S  +F+IPL ++++ YC    V +
Sbjct: 184 GVSVPIPVIGLRDEEKVFVNNTTC-VLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLR 242

Query: 232 RTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSST----------KAKGHNPRSSIAV 281
           R    L  G  +E        L+   +N  E+  S+           K K   PR ++  
Sbjct: 243 RQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQA 302

Query: 282 KLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFS---TLKPPDAVFKVVFWLGY 338
                + E+KA+K LGIV  +F++ W PFFI   L  L       K  + +  V  W+GY
Sbjct: 303 ----INNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGY 358

Query: 339 FNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYR 389
             S +NP++Y   +K ++RAF   L C  +   +   R+  R+   A + R
Sbjct: 359 VCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGR 409


>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
           sapiens]
          Length = 440

 Score =  178 bits (452), Expect = 9e-45
 Identities = 108/322 (33%), Positives = 167/322 (51%), Gaps = 17/322 (5%)

Query: 48  VGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEV 107
           V   L   I      N L+I  +     LR  +N+F+V+L  +DL++   V+P +    +
Sbjct: 29  VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88

Query: 108 LGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALL 167
            G WVL R  C +W A DV+CC+ASIL+LC IS+DRY+ +   L+Y   +T  +A+  +L
Sbjct: 89  YGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVL 148

Query: 168 SVWVLSTVISIGP-LLGWKE---PAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMY 223
             W L+ + S  P LLGW E     P    +C +     + L +S  +F++P   I   Y
Sbjct: 149 GAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTY 208

Query: 224 CRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKL 283
           CR+ + A++    + A +   M++    TL++            T   G     S  +  
Sbjct: 209 CRILLAARKQAVQV-ASLTTGMASQASETLQV----------PRTPRPGVESADSRRLAT 257

Query: 284 FKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCL 343
               +  KA+ TLGI++GMF + WLPFF+A  + ++   + P   +F V+ WLGY NS +
Sbjct: 258 KHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISP--GLFDVLTWLGYCNSTM 315

Query: 344 NPIIYPCSSKEFKRAFVRILGC 365
           NPIIYP   ++FKRA  R L C
Sbjct: 316 NPIIYPLFMRDFKRALGRFLPC 337


>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
          Length = 359

 Score =  177 bits (450), Expect = 2e-44
 Identities = 117/329 (35%), Positives = 166/329 (50%), Gaps = 40/329 (12%)

Query: 52  LGAFILFAIVGNILVILSVACNRHLRT-PTNYFIVNLAMADLLLSFTVLPFSAALEVLGY 110
           L   IL AI+GN+LV+++V  +R LR   TNYFIV+LA ADLL+S  V+PF A   V   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 111 WVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGV-RYSLQYPTLVTRRKAILALLSV 169
           W+ G +FC +  ++DVL  TASI  LC IS+DRY  +    L Y   +T  +  L L   
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 170 WVLSTVISIGPLL-GW------------KEPAPNDDKECGVTEEPFYALFSSLGSFYIPL 216
           WV+ T IS  P++ GW            K    ++   C       YA+  S+ +FYIP 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 217 AVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPR 276
            ++++ Y R+Y+ AK     ++  +++    S E                        P+
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQ--MLQRAGASSE----------------------SRPQ 241

Query: 277 SSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWL 336
           S+      +   E KAAKTL I++G F LCW PFF+   +   F     P  V+    WL
Sbjct: 242 SADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVT-NIVDPFIDYTVPGQVWTAFLWL 300

Query: 337 GYFNSCLNPIIYPCSSKEFKRAFVRILGC 365
           GY NS LNP +Y   +K F+RAF+ IL C
Sbjct: 301 GYINSGLNPFLYAFLNKSFRRAFLIILCC 329


>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
          Length = 428

 Score =  177 bits (450), Expect = 2e-44
 Identities = 117/329 (35%), Positives = 166/329 (50%), Gaps = 40/329 (12%)

Query: 52  LGAFILFAIVGNILVILSVACNRHLRT-PTNYFIVNLAMADLLLSFTVLPFSAALEVLGY 110
           L   IL AI+GN+LV+++V  +R LR   TNYFIV+LA ADLL+S  V+PF A   V   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 111 WVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGV-RYSLQYPTLVTRRKAILALLSV 169
           W+ G +FC +  ++DVL  TASI  LC IS+DRY  +    L Y   +T  +  L L   
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 170 WVLSTVISIGPLL-GW------------KEPAPNDDKECGVTEEPFYALFSSLGSFYIPL 216
           WV+ T IS  P++ GW            K    ++   C       YA+  S+ +FYIP 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 217 AVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPR 276
            ++++ Y R+Y+ AK     ++  +++    S E                        P+
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQ--MLQRAGASSE----------------------SRPQ 241

Query: 277 SSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWL 336
           S+      +   E KAAKTL I++G F LCW PFF+   +   F     P  V+    WL
Sbjct: 242 SADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVT-NIVDPFIDYTVPGQVWTAFLWL 300

Query: 337 GYFNSCLNPIIYPCSSKEFKRAFVRILGC 365
           GY NS LNP +Y   +K F+RAF+ IL C
Sbjct: 301 GYINSGLNPFLYAFLNKSFRRAFLIILCC 329


>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
          Length = 360

 Score =  177 bits (450), Expect = 2e-44
 Identities = 117/329 (35%), Positives = 166/329 (50%), Gaps = 40/329 (12%)

Query: 52  LGAFILFAIVGNILVILSVACNRHLRT-PTNYFIVNLAMADLLLSFTVLPFSAALEVLGY 110
           L   IL AI+GN+LV+++V  +R LR   TNYFIV+LA ADLL+S  V+PF A   V   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 111 WVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGV-RYSLQYPTLVTRRKAILALLSV 169
           W+ G +FC +  ++DVL  TASI  LC IS+DRY  +    L Y   +T  +  L L   
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 170 WVLSTVISIGPLL-GW------------KEPAPNDDKECGVTEEPFYALFSSLGSFYIPL 216
           WV+ T IS  P++ GW            K    ++   C       YA+  S+ +FYIP 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 217 AVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPR 276
            ++++ Y R+Y+ AK     ++  +++    S E                        P+
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQ--MLQRAGASSE----------------------SRPQ 241

Query: 277 SSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWL 336
           S+      +   E KAAKTL I++G F LCW PFF+   +   F     P  V+    WL
Sbjct: 242 SADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVT-NIVDPFIDYTVPGQVWTAFLWL 300

Query: 337 GYFNSCLNPIIYPCSSKEFKRAFVRILGC 365
           GY NS LNP +Y   +K F+RAF+ IL C
Sbjct: 301 GYINSGLNPFLYAFLNKSFRRAFLIILCC 329


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,230,446
Number of Sequences: 37866
Number of extensions: 1164629
Number of successful extensions: 6483
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 650
Number of HSP's successfully gapped in prelim test: 214
Number of HSP's that attempted gapping in prelim test: 4315
Number of HSP's gapped (non-prelim): 1564
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.