Search of human proteins with 4501957

Search of human proteins with 4501957

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
         (572 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]               1149   0.0  
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                478   e-135
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    433   e-121
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    433   e-121
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    433   e-121
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    433   e-121
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                  226   4e-59
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa...   219   7e-57
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]               214   2e-55
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]   213   5e-55
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]   213   5e-55
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]    213   5e-55
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]      206   4e-53
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]               203   3e-52
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   203   4e-52
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa...   202   7e-52
gi|4503383 dopamine receptor D1 [Homo sapiens]                        201   2e-51
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]           199   7e-51
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]            199   7e-51
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]             198   1e-50
gi|4503391 dopamine receptor D5 [Homo sapiens]                        197   2e-50
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]             192   5e-49
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]         192   5e-49
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   191   1e-48
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]         188   1e-47
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]         187   2e-47
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]         187   2e-47
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]         187   2e-47
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]         187   2e-47
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]         187   2e-47

>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score = 1149 bits (2973), Expect = 0.0
 Identities = 572/572 (100%), Positives = 572/572 (100%)

Query: 1   MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG 60
           MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
Sbjct: 1   MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG 60

Query: 61  SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS 120
           SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
Sbjct: 61  SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS 120

Query: 121 VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC 180
           VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
Sbjct: 121 VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC 180

Query: 181 TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP 240
           TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
Sbjct: 181 TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP 240

Query: 241 PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS 300
           PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
Sbjct: 241 PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS 300

Query: 301 EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC 360
           EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
Sbjct: 301 EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC 360

Query: 361 WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ 420
           WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
Sbjct: 361 WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ 420

Query: 421 CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM 480
           CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
Sbjct: 421 CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM 480

Query: 481 QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE 540
           QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
Sbjct: 481 QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE 540

Query: 541 AVSLGVPHEVAEGATCQAYELADYSNLRETDI 572
           AVSLGVPHEVAEGATCQAYELADYSNLRETDI
Sbjct: 541 AVSLGVPHEVAEGATCQAYELADYSNLRETDI 572


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score =  478 bits (1231), Expect = e-135
 Identities = 244/422 (57%), Positives = 299/422 (70%), Gaps = 29/422 (6%)

Query: 95  QGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSA 154
           + + VG+ L AFIL A+ GN+LVILSVACNRHL+T TNYFIVNLA+ADLLLS TVLPFSA
Sbjct: 44  RAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSA 103

Query: 155 TMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAA 214
            +EVLG+W  GR FCD+WAAVDVLCCTASILSLC IS+DRY+GVR+SL+YP ++T RKA 
Sbjct: 104 ALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAI 163

Query: 215 AILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMY 274
             L  +WV++ V+S+GPLLGWKEP P D++ CG+TEE  YA+FSS+ SFY+P+AVI+VMY
Sbjct: 164 LALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMY 223

Query: 275 CRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLS 334
           CRVY+VA+ TT++LEAGV +E   + E+ LRIH +      +       AKGH  RSS++
Sbjct: 224 CRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNF---HEDTLSSTKAKGHNPRSSIA 280

Query: 335 VRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFN 394
           V+L KFSREKKAAKTL IVVG+F+LCW PFF  LPLGSLF  LKP + VFKV+FWLGYFN
Sbjct: 281 VKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFN 340

Query: 395 SCVNPLIYPCSSREFKRAFLRLLRCQC-----RRRRRRRPL------WRVYGHHWRASTS 443
           SC+NP+IYPCSS+EFKRAF+R+L CQC     RRRRRRR L      +R +        S
Sbjct: 341 SCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERS 400

Query: 444 GLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPP----SAFREWRL 499
             R+D    SG    G+      LP   P P            R  PP     AF EW+ 
Sbjct: 401 QSRKDSLDDSGSCLSGSQ---RTLPSASPSP--------GYLGRGAPPPVELCAFPEWKA 449

Query: 500 LG 501
            G
Sbjct: 450 PG 451


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  433 bits (1113), Expect = e-121
 Identities = 203/333 (60%), Positives = 259/333 (77%), Gaps = 6/333 (1%)

Query: 94  AQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFS 153
           ++ + +GV L   IL  V GN+LVILSVAC+RHL +VT+Y+IVNLAVADLLL++TVLPFS
Sbjct: 24  SKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFS 83

Query: 154 ATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKA 213
           A  EVLG+WAFGR FC++WAAVDVLCCTASI+ LC IS+DRY+GV + L+YP I+T+R+ 
Sbjct: 84  AIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRG 143

Query: 214 AAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVM 273
              L  +W ++LV+S+GPL GW++P P DE  C I EE GY +FS++ SFYLP+A+I+VM
Sbjct: 144 LMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVM 203

Query: 274 YCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSL 333
           YCRVYVVA+  +R L++G+K ++  + +V LRIH + A  G     GM SAK  T     
Sbjct: 204 YCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS---GMASAKTKT---HF 257

Query: 334 SVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYF 393
           SVRLLKFSREKKAAKTL IVVG FVLCW PFF V+P+GS FP  KPSE VFK++FWLGY 
Sbjct: 258 SVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYL 317

Query: 394 NSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
           NSC+NP+IYPCSS+EFK+AF  +LR QC  R++
Sbjct: 318 NSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  433 bits (1113), Expect = e-121
 Identities = 203/333 (60%), Positives = 259/333 (77%), Gaps = 6/333 (1%)

Query: 94  AQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFS 153
           ++ + +GV L   IL  V GN+LVILSVAC+RHL +VT+Y+IVNLAVADLLL++TVLPFS
Sbjct: 24  SKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFS 83

Query: 154 ATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKA 213
           A  EVLG+WAFGR FC++WAAVDVLCCTASI+ LC IS+DRY+GV + L+YP I+T+R+ 
Sbjct: 84  AIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRG 143

Query: 214 AAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVM 273
              L  +W ++LV+S+GPL GW++P P DE  C I EE GY +FS++ SFYLP+A+I+VM
Sbjct: 144 LMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVM 203

Query: 274 YCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSL 333
           YCRVYVVA+  +R L++G+K ++  + +V LRIH + A  G     GM SAK  T     
Sbjct: 204 YCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS---GMASAKTKT---HF 257

Query: 334 SVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYF 393
           SVRLLKFSREKKAAKTL IVVG FVLCW PFF V+P+GS FP  KPSE VFK++FWLGY 
Sbjct: 258 SVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYL 317

Query: 394 NSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
           NSC+NP+IYPCSS+EFK+AF  +LR QC  R++
Sbjct: 318 NSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  433 bits (1113), Expect = e-121
 Identities = 203/333 (60%), Positives = 259/333 (77%), Gaps = 6/333 (1%)

Query: 94  AQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFS 153
           ++ + +GV L   IL  V GN+LVILSVAC+RHL +VT+Y+IVNLAVADLLL++TVLPFS
Sbjct: 24  SKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFS 83

Query: 154 ATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKA 213
           A  EVLG+WAFGR FC++WAAVDVLCCTASI+ LC IS+DRY+GV + L+YP I+T+R+ 
Sbjct: 84  AIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRG 143

Query: 214 AAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVM 273
              L  +W ++LV+S+GPL GW++P P DE  C I EE GY +FS++ SFYLP+A+I+VM
Sbjct: 144 LMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVM 203

Query: 274 YCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSL 333
           YCRVYVVA+  +R L++G+K ++  + +V LRIH + A  G     GM SAK  T     
Sbjct: 204 YCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS---GMASAKTKT---HF 257

Query: 334 SVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYF 393
           SVRLLKFSREKKAAKTL IVVG FVLCW PFF V+P+GS FP  KPSE VFK++FWLGY 
Sbjct: 258 SVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYL 317

Query: 394 NSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
           NSC+NP+IYPCSS+EFK+AF  +LR QC  R++
Sbjct: 318 NSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  433 bits (1113), Expect = e-121
 Identities = 203/333 (60%), Positives = 259/333 (77%), Gaps = 6/333 (1%)

Query: 94  AQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFS 153
           ++ + +GV L   IL  V GN+LVILSVAC+RHL +VT+Y+IVNLAVADLLL++TVLPFS
Sbjct: 24  SKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFS 83

Query: 154 ATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKA 213
           A  EVLG+WAFGR FC++WAAVDVLCCTASI+ LC IS+DRY+GV + L+YP I+T+R+ 
Sbjct: 84  AIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRG 143

Query: 214 AAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVM 273
              L  +W ++LV+S+GPL GW++P P DE  C I EE GY +FS++ SFYLP+A+I+VM
Sbjct: 144 LMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVM 203

Query: 274 YCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSL 333
           YCRVYVVA+  +R L++G+K ++  + +V LRIH + A  G     GM SAK  T     
Sbjct: 204 YCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS---GMASAKTKT---HF 257

Query: 334 SVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYF 393
           SVRLLKFSREKKAAKTL IVVG FVLCW PFF V+P+GS FP  KPSE VFK++FWLGY 
Sbjct: 258 SVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYL 317

Query: 394 NSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
           NSC+NP+IYPCSS+EFK+AF  +LR QC  R++
Sbjct: 318 NSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score =  226 bits (576), Expect = 4e-59
 Identities = 150/433 (34%), Positives = 224/433 (51%), Gaps = 36/433 (8%)

Query: 53  GGGVVGAGSGEDNRSSAGEP---GSAGAGGDVNGTAAVGGLVVSAQG----------VGV 99
           G GV+  G+ E    S+  P   G+A A   +   +    L+  A             G+
Sbjct: 2   GAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGM 61

Query: 100 GVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVL 159
           G+ +A  +L+ VAGN+LVI+++A    LQT+TN FI++LA ADL++   V+PF AT+ V 
Sbjct: 62  GLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVW 121

Query: 160 GFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILAL 219
           G W +G  FC++W +VDVLC TASI +LC I++DRY+ +    +Y +++T  +A  ++  
Sbjct: 122 GRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCT 181

Query: 220 LWVVALVVSVGPLL--GWKEPVPP------DERFCGITEEAGYAVFSSVCSFYLPMAVIV 271
           +W ++ +VS  P+L   W+           D + C       YA+ SSV SFY+P+ ++ 
Sbjct: 182 VWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMA 241

Query: 272 VMYCRVYVVARSTTRSLEAGVKRERG--------KASEVVLRIHCRGAATGADGAHGMRS 323
            +Y RV+  A+   + +++  +R  G          S V       G    A  A     
Sbjct: 242 FVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPL 301

Query: 324 AKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGV 383
           A G   +   S RL+   RE+KA KTL I++GVF LCW PFF    + +   +L P + +
Sbjct: 302 ANGRAGKRRPS-RLVAL-REQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVP-DRL 358

Query: 384 FKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTS 443
           F    WLGY NS  NP+IY C S +F++AF  LL C  R  RRR      +G   RAS  
Sbjct: 359 FVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLLCCARRAARRRH---ATHGDRPRASGC 414

Query: 444 GLRQDCAPSSGDA 456
             R    PS G A
Sbjct: 415 LARPGPPPSPGAA 427


>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
           sapiens]
          Length = 422

 Score =  219 bits (557), Expect = 7e-57
 Identities = 137/429 (31%), Positives = 219/429 (51%), Gaps = 70/429 (16%)

Query: 56  VVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNL 115
           V+  G G +  S    P     GG+  G   +  + VS Q +   + L   I  AV GN 
Sbjct: 3   VLSPGQGNNTTSP---PAPFETGGNTTG---ISDVTVSYQVI-TSLLLGTLIFCAVLGNA 55

Query: 116 LVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAV 175
            V+ ++A  R LQ V NY I +LAV DL++S  VLP +A  +VL  W  G+  CD++ A+
Sbjct: 56  CVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIAL 115

Query: 176 DVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGW 235
           DVLCCT+SIL LC I++DRY  +   + Y    T R+AAA+++L W++  ++S+ P+LGW
Sbjct: 116 DVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW 175

Query: 236 KEPVP-PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVAR------------ 282
           + P    D   C I+++ GY ++S+  +FY+P+ +++V+Y R++  AR            
Sbjct: 176 RTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEK 235

Query: 283 ----------------------STTRSLEAGVKRERGKA--SEVVLRIHCRGAATGADGA 318
                                 S +R+   GV+ + G A  +   +R    GAA      
Sbjct: 236 TGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEV 295

Query: 319 HGMRSAKGH--------------------TFRSSLSVRLLKFSREKKAAKTLAIVVGVFV 358
           H + ++K H                      R++ + R +  +RE+K  KTL I++G F+
Sbjct: 296 HRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFI 355

Query: 359 LCWFPFF---FVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLR 415
           LCW PFF    VLP       +    G   +I WLGY NS +NP+IY   +++F+ AF +
Sbjct: 356 LCWLPFFIVALVLPFCESSCHMPTLLGA--IINWLGYSNSLLNPVIYAYFNKDFQNAFKK 413

Query: 416 LLRCQ-CRR 423
           +++C+ CR+
Sbjct: 414 IIKCKFCRQ 422


>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
          Length = 408

 Score =  214 bits (545), Expect = 2e-55
 Identities = 142/363 (39%), Positives = 193/363 (53%), Gaps = 32/363 (8%)

Query: 84  TAAVGGLV-VSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVAD 142
           TA   GL  V  +    G  LA  +L  V GNLLVI+++A    LQT+TN F+ +LA AD
Sbjct: 24  TANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAAD 83

Query: 143 LLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSL 202
           L++   V+P +AT+ + G W  G   C++W +VDVLC TASI +LC ++VDRY+ V + L
Sbjct: 84  LVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPL 143

Query: 203 KYPAIMTERKAAAILALLWVVALVVSVGPLLG--WK-------EPVPPDERFCGITEEAG 253
           +Y A++T+R A   + L+WVV+  VS  P++   W+       +    + R C       
Sbjct: 144 RYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMP 203

Query: 254 YAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKR----ERGKASEVVLRIHCR 309
           Y + SS  SFYLP+ V++ +Y RV+VVA    R L   + R    E   A    L     
Sbjct: 204 YVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPV 263

Query: 310 GAATGADG--AHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFV 367
           G     +G  A G R A           RLL   RE +A  TL +++G F LCW PFF  
Sbjct: 264 GTCAPPEGVPACGRRPA-----------RLLPL-REHRALCTLGLIMGTFTLCWLPFFLA 311

Query: 368 LPLGSL-FPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
             L +L  P L P    F  + WLGY NS  NPLIY C S +F+ AF RLL C+C RR  
Sbjct: 312 NVLRALGGPSLVPGP-AFLALNWLGYANSAFNPLIY-CRSPDFRSAFRRLL-CRCGRRLP 368

Query: 427 RRP 429
             P
Sbjct: 369 PEP 371


>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
          Length = 432

 Score =  213 bits (541), Expect = 5e-55
 Identities = 134/396 (33%), Positives = 213/396 (53%), Gaps = 17/396 (4%)

Query: 41  PAVG-GVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVS---AQG 96
           P VG G+P  +  GG    AGS   +  S      A         A+  G  ++    + 
Sbjct: 22  PEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK 81

Query: 97  VGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATM 156
           V +G  L    L+ +AGN LV++SV   + L+  +NY IV+LA+ADL ++  V+PF +  
Sbjct: 82  VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141

Query: 157 EVLGF-WAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAA 215
           +++G  W FG  FC+V+ A+DV+CCTASI++LC IS+DRY+G+   L YP     +  A 
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201

Query: 216 ILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYC 275
           ++  +W+++  +++ PL GW + V  D++ C I+++ GY ++S+  +FY+PM+V++ MY 
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNVN-DDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260

Query: 276 RVYVVAR-STTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLS 334
           ++Y  AR S  +    G  R     S + L    +      + A+  R  K    R ++S
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPD-SVIALNGIVKLQKEVEECANLSRLLKHE--RKNIS 317

Query: 335 VRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS---EGVFKVIFWLG 391
           +    F RE+KAA TL I+VG F +CW PFF +            S     V +   WLG
Sbjct: 318 I----FKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373

Query: 392 YFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRR 427
           Y NS +NP IY   +R+ +  +  LL+CQ R   R+
Sbjct: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRK 409


>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
          Length = 479

 Score =  213 bits (541), Expect = 5e-55
 Identities = 134/396 (33%), Positives = 213/396 (53%), Gaps = 17/396 (4%)

Query: 41  PAVG-GVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVS---AQG 96
           P VG G+P  +  GG    AGS   +  S      A         A+  G  ++    + 
Sbjct: 22  PEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK 81

Query: 97  VGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATM 156
           V +G  L    L+ +AGN LV++SV   + L+  +NY IV+LA+ADL ++  V+PF +  
Sbjct: 82  VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141

Query: 157 EVLGF-WAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAA 215
           +++G  W FG  FC+V+ A+DV+CCTASI++LC IS+DRY+G+   L YP     +  A 
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201

Query: 216 ILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYC 275
           ++  +W+++  +++ PL GW + V  D++ C I+++ GY ++S+  +FY+PM+V++ MY 
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNVN-DDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260

Query: 276 RVYVVAR-STTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLS 334
           ++Y  AR S  +    G  R     S + L    +      + A+  R  K    R ++S
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPD-SVIALNGIVKLQKEVEECANLSRLLKHE--RKNIS 317

Query: 335 VRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS---EGVFKVIFWLG 391
           +    F RE+KAA TL I+VG F +CW PFF +            S     V +   WLG
Sbjct: 318 I----FKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373

Query: 392 YFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRR 427
           Y NS +NP IY   +R+ +  +  LL+CQ R   R+
Sbjct: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRK 409


>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
          Length = 445

 Score =  213 bits (541), Expect = 5e-55
 Identities = 134/396 (33%), Positives = 213/396 (53%), Gaps = 17/396 (4%)

Query: 41  PAVG-GVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVS---AQG 96
           P VG G+P  +  GG    AGS   +  S      A         A+  G  ++    + 
Sbjct: 22  PEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK 81

Query: 97  VGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATM 156
           V +G  L    L+ +AGN LV++SV   + L+  +NY IV+LA+ADL ++  V+PF +  
Sbjct: 82  VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141

Query: 157 EVLGF-WAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAA 215
           +++G  W FG  FC+V+ A+DV+CCTASI++LC IS+DRY+G+   L YP     +  A 
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201

Query: 216 ILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYC 275
           ++  +W+++  +++ PL GW + V  D++ C I+++ GY ++S+  +FY+PM+V++ MY 
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNVN-DDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260

Query: 276 RVYVVAR-STTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLS 334
           ++Y  AR S  +    G  R     S + L    +      + A+  R  K    R ++S
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPD-SVIALNGIVKLQKEVEECANLSRLLKHE--RKNIS 317

Query: 335 VRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS---EGVFKVIFWLG 391
           +    F RE+KAA TL I+VG F +CW PFF +            S     V +   WLG
Sbjct: 318 I----FKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373

Query: 392 YFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRR 427
           Y NS +NP IY   +R+ +  +  LL+CQ R   R+
Sbjct: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRK 409


>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
          Length = 413

 Score =  206 bits (525), Expect = 4e-53
 Identities = 126/337 (37%), Positives = 183/337 (54%), Gaps = 35/337 (10%)

Query: 97  VGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATM 156
           VG+G+ ++  +L  V GN+LVI ++A    LQTVTNYFI +LA ADL++   V+PF A  
Sbjct: 34  VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAH 93

Query: 157 EVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAI 216
            ++  W FG  +C+ W ++DVLC TASI +LC I+VDRY  +    KY +++T+ KA  I
Sbjct: 94  ILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVI 153

Query: 217 LALLWVVALVVSVGPL-LGWKEPVPPD-------ERFCGITEEAGYAVFSSVCSFYLPMA 268
           + ++W+V+ + S  P+ + W      +       E  C       YA+ SS+ SFY+P+ 
Sbjct: 154 ILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLV 213

Query: 269 VIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRG-AATGADGAHGMRSAKGH 327
           ++V +Y RV+  A           KR+  K  +   R H +  +    DG        GH
Sbjct: 214 IMVFVYSRVFQEA-----------KRQLQKIDKSEGRFHVQNLSQVEQDG------RTGH 256

Query: 328 TFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVI 387
             R S    L    +E KA KTL I++G F LCW PFF V  +  +   L   E V+ ++
Sbjct: 257 GLRRSSKFCL----KEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKE-VYILL 311

Query: 388 FWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRR 424
            W+GY NS  NPLIY C S +F+ AF  LL   C RR
Sbjct: 312 NWIGYVNSGFNPLIY-CRSPDFRIAFQELL---CLRR 344


>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
          Length = 462

 Score =  203 bits (517), Expect = 3e-52
 Identities = 148/476 (31%), Positives = 226/476 (47%), Gaps = 105/476 (22%)

Query: 31  SAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGL 90
           +A   A + GP   G   G  G GGV  A       +S G P    + G V G AAV G 
Sbjct: 8   AALAVAAAAGPNASGA--GERGSGGVANASG-----ASWGPPRGQYSAGAVAGLAAVVGF 60

Query: 91  VVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVL 150
           +               I+  V GN+LV+++V  +R L+   N F+V+LA AD+L++  V+
Sbjct: 61  L---------------IVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVM 105

Query: 151 PFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTE 210
           PFS   E++ +W FG+ +C V+ A+DVL CT+SI+ LC IS+DRY  V  +++Y    T 
Sbjct: 106 PFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTP 165

Query: 211 RKAAAILALLWVVALVVSVGPLLG-WKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAV 269
           R+  A +  +W+++ V+S  PL+  +++P       CG+ +E  Y + S + SF+ P  +
Sbjct: 166 RRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLI 225

Query: 270 IVVMYCRVYVVARSTTRSL----------------------------------------- 288
           + ++Y R+Y VA+  TR+L                                         
Sbjct: 226 MGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEP 285

Query: 289 -EAGVKRERGKASEVVLRIHCR--GAATGADGAHGMRSAKGHTFRSSL------------ 333
            E+    ER +    + R   R  GA  GA GA G  +  G     +L            
Sbjct: 286 DESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRL 345

Query: 334 ---SVRLLKF--SREKKAAKT-----------------LAIVVGVFVLCWFPFFFVLPLG 371
              S R ++F  SR ++A  +                 LA+V+GVFVLCWFPFFF   L 
Sbjct: 346 SRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLY 405

Query: 372 SLFPQLKPSEG-VFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
            +  +     G +FK  FW+GY NS +NP+IY   +++F+R+F  +L    RRRRR
Sbjct: 406 GICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHIL---FRRRRR 458



 Score = 29.6 bits (65), Expect = 7.8
 Identities = 23/66 (34%), Positives = 24/66 (36%), Gaps = 1/66 (1%)

Query: 14  PRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPG 73
           P  D     SSA        GA    G    G  GGAGG  G  GAG G     +     
Sbjct: 279 PPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADG-QGAGPGAAESGALTASR 337

Query: 74  SAGAGG 79
           S G GG
Sbjct: 338 SPGPGG 343


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  203 bits (516), Expect = 4e-52
 Identities = 117/341 (34%), Positives = 180/341 (52%), Gaps = 26/341 (7%)

Query: 101 VFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLG 160
           + LA   L     N  VI +V   R L T  NY I +LAV DLL+S  V+P S    V G
Sbjct: 54  MLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTG 113

Query: 161 FWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALL 220
            W  G+  CD W + D+ CCTASIL LC I++DRY  +  +++Y A  T ++AA ++AL+
Sbjct: 114 RWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALV 173

Query: 221 WVVALVVSVGPLLGWKEPVPPDE-RFCGI-TEEAGYAVFSSVCSFYLPMAVIVVMYCRVY 278
           WV ++ +S+ P   W++    +E   C + T+   Y V+S+V +FY P  +++ +Y R+Y
Sbjct: 174 WVFSISISLPPFF-WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIY 232

Query: 279 VVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHG--------------MRSA 324
           V ARS  R L+    R   + +   L     G+ +     +               +   
Sbjct: 233 VEARS--RILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQV 290

Query: 325 KGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS---- 380
           K     + L  + L  +RE+KA KTL I++G F++CW PFF +     + P  K +    
Sbjct: 291 KVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFII---SLVMPICKDACWFH 347

Query: 381 EGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQC 421
             +F    WLGY NS +NP+IY  S+ +FK+AF +L+R +C
Sbjct: 348 LAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKC 388


>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
           sapiens]
          Length = 366

 Score =  202 bits (514), Expect = 7e-52
 Identities = 109/341 (31%), Positives = 180/341 (52%), Gaps = 18/341 (5%)

Query: 99  VGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEV 158
           V + L+   LM    N LVI ++   R L    NY I +LAV D L++  V+PFS    V
Sbjct: 26  VSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIV 85

Query: 159 LGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILA 218
              W  G+  CD+W +VD+ CCT SIL L  I++DRY  +  +++Y    T + A  ++ 
Sbjct: 86  RESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIT 145

Query: 219 LLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVY 278
           ++W++++ +S+ PL    +    D+      +     ++S+  +FY+P+A+I+++Y ++Y
Sbjct: 146 IVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIY 205

Query: 279 VVARSTTRS----------------LEAGVKRERGKASEVVLRIHCRGAATGADGAHGMR 322
             A++                    LE+G K  +  ++  VL       +T  D  H   
Sbjct: 206 RAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTV 265

Query: 323 SAKGHTFRSSLSVRLLKFS--REKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS 380
            +    F+   S R  K S  RE+KAA TL +++G FV+CW PFF    + ++  + K S
Sbjct: 266 RSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKIS 325

Query: 381 EGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQC 421
           E +   + WLGY NS +NPLIY   + +FK+AF +L+RC+C
Sbjct: 326 EEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC 366


>gi|4503383 dopamine receptor D1 [Homo sapiens]
          Length = 446

 Score =  201 bits (510), Expect = 2e-51
 Identities = 122/338 (36%), Positives = 186/338 (55%), Gaps = 39/338 (11%)

Query: 102 FLAAFILMAVAGNLLVILSVACNRHLQT-VTNYFIVNLAVADLLLSATVLPFSATMEVLG 160
           FL+  IL  + GN LV  +V   RHL++ VTN+F+++LAV+DLL++  V+P+ A  E+ G
Sbjct: 29  FLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG 88

Query: 161 FWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALL 220
           FW FG +FC++W A D++C TASIL+LC ISVDRY  +    +Y   MT + A  ++++ 
Sbjct: 89  FWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVA 147

Query: 221 WVVALVVSVGPL-LGW---KEPVPPDERFCGITE---------EAGYAVFSSVCSFYLPM 267
           W +++++S  P+ L W   K   P D     + E            YA+ SSV SFY+P+
Sbjct: 148 WTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPV 207

Query: 268 AVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGH 327
           A+++V Y R+Y +A+   R + A    ER         +H +   T       +  ++  
Sbjct: 208 AIMIVTYTRIYRIAQKQIRRIAA---LERA-------AVHAKNCQTTTGNGKPVECSQPE 257

Query: 328 TFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFF---VLPL---GSLFPQLKPSE 381
                 S   + F RE K  KTL++++GVFV CW PFF    +LP    G   P    S 
Sbjct: 258 ------SSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDS- 310

Query: 382 GVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRC 419
             F V  W G+ NS +NP+IY  ++ +F++AF  LL C
Sbjct: 311 NTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGC 347


>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
          Length = 397

 Score =  199 bits (505), Expect = 7e-51
 Identities = 117/353 (33%), Positives = 182/353 (51%), Gaps = 48/353 (13%)

Query: 82  NGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVA 141
           NGTA+   L  +A  + + V LA  IL+ VAGN++V L+V  NR L+ +TN FIV+LA+ 
Sbjct: 4   NGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAIT 63

Query: 142 DLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHS 201
           DLLL   VLPFSA  ++   W+FG+ FC+++ ++DV+ CTASIL+L  IS+DRY  V   
Sbjct: 64  DLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDP 123

Query: 202 LKYPAIMTERKAAAILALLWVVALVVSVGPL-LGWKEPVPPDE-----RFCGITEEAGYA 255
           L+YP ++T  + A  L L+WV+++ +S   + LGW       +       C +     Y 
Sbjct: 124 LRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYG 183

Query: 256 VFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGA 315
           +   + +FYLP+ ++ + Y R++ VAR   + +                 I    AAT  
Sbjct: 184 LVDGLVTFYLPLLIMCITYYRIFKVARDQAKRIN---------------HISSWKAAT-- 226

Query: 316 DGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFP 375
                                     RE KA  TLA V+G F++CWFP+F       L  
Sbjct: 227 -------------------------IREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRG 261

Query: 376 QLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRR 428
               +E +  ++ WLGY NS +NP++Y   +R+F+  + +L  C+   R   +
Sbjct: 262 DDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHK 314


>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
          Length = 359

 Score =  199 bits (505), Expect = 7e-51
 Identities = 117/353 (33%), Positives = 182/353 (51%), Gaps = 48/353 (13%)

Query: 82  NGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVA 141
           NGTA+   L  +A  + + V LA  IL+ VAGN++V L+V  NR L+ +TN FIV+LA+ 
Sbjct: 4   NGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAIT 63

Query: 142 DLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHS 201
           DLLL   VLPFSA  ++   W+FG+ FC+++ ++DV+ CTASIL+L  IS+DRY  V   
Sbjct: 64  DLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDP 123

Query: 202 LKYPAIMTERKAAAILALLWVVALVVSVGPL-LGWKEPVPPDE-----RFCGITEEAGYA 255
           L+YP ++T  + A  L L+WV+++ +S   + LGW       +       C +     Y 
Sbjct: 124 LRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYG 183

Query: 256 VFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGA 315
           +   + +FYLP+ ++ + Y R++ VAR   + +                 I    AAT  
Sbjct: 184 LVDGLVTFYLPLLIMCITYYRIFKVARDQAKRIN---------------HISSWKAAT-- 226

Query: 316 DGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFP 375
                                     RE KA  TLA V+G F++CWFP+F       L  
Sbjct: 227 -------------------------IREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRG 261

Query: 376 QLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRR 428
               +E +  ++ WLGY NS +NP++Y   +R+F+  + +L  C+   R   +
Sbjct: 262 DDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHK 314


>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
          Length = 367

 Score =  198 bits (504), Expect = 1e-50
 Identities = 124/336 (36%), Positives = 176/336 (52%), Gaps = 27/336 (8%)

Query: 105 AFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLG-FWA 163
           A IL  V GN LV ++V   R LQT TNY +V+LAVADLL++  V+P+   +EV G  W 
Sbjct: 38  ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97

Query: 164 FGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTE---RKAAAILALL 220
           F R  CDV+  +DV+ CTASIL+LC IS+DRY  V   + Y     +   R+ A ++  +
Sbjct: 98  FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAV 157

Query: 221 WVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVV 280
           WV+A  VS   L G+      D   C I+    + ++SSV SFYLP  V V++Y R+YVV
Sbjct: 158 WVLAFAVSCPLLFGFN--TTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVV 214

Query: 281 ARSTTR------------SLEAGVKRERGKASEVVLRIH-----CRGAATGADGAHGMRS 323
            +   R            S+  G  ++        L +      C+  A G  G    + 
Sbjct: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPG---FQE 271

Query: 324 AKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGV 383
             G   R   +   L   REKKA + +AIV+G F++CW PFF    L +       S  +
Sbjct: 272 RGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPEL 331

Query: 384 FKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRC 419
           +    WLGY NS +NP+IY   + EF++AFL++L C
Sbjct: 332 YSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367


>gi|4503391 dopamine receptor D5 [Homo sapiens]
          Length = 477

 Score =  197 bits (501), Expect = 2e-50
 Identities = 129/379 (34%), Positives = 197/379 (51%), Gaps = 64/379 (16%)

Query: 78  GGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQT-VTNYFIV 136
           G  V G+A  G   +    V     L   I+  + GN+LV  ++  +RHL+  +TN FIV
Sbjct: 24  GNAVGGSA--GAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIV 81

Query: 137 NLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYV 196
           +LAV+DL ++  V+P+ A  EV G+W FG AFCDVW A D++C TASIL+LC ISVDRY 
Sbjct: 82  SLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYW 140

Query: 197 GVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPL-LGWKEP----------------- 238
            +    +Y   MT+R A  ++ L W +++++S  P+ L W                    
Sbjct: 141 AISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANW 200

Query: 239 VPPDERF---------CGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLE 289
            P +E F         C  +    YA+ SS+ SFY+P+A+++V Y R+Y +A+   R + 
Sbjct: 201 TPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRI- 259

Query: 290 AGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKT 349
           + ++R    A        CR +A           A   + R+S+        +E K  KT
Sbjct: 260 SSLERAAEHAQS------CRSSAA---------CAPDTSLRASI-------KKETKVLKT 297

Query: 350 LAIVVGVFVLCWFPFFF---VLPLGSLFPQLKP------SEGVFKVIFWLGYFNSCVNPL 400
           L++++GVFV CW PFF    ++P  S  P+  P      SE  F V  W G+ NS +NP+
Sbjct: 298 LSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPV 357

Query: 401 IYPCSSREFKRAFLRLLRC 419
           IY  ++ +F++ F +LL C
Sbjct: 358 IYAFNA-DFQKVFAQLLGC 375


>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
          Length = 400

 Score =  192 bits (489), Expect = 5e-49
 Identities = 127/366 (34%), Positives = 181/366 (49%), Gaps = 54/366 (14%)

Query: 105 AFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLG-FWA 163
           A IL  V GN LV ++V   R LQT TNY +V+LAVADLL++  V+P+   +EV G  W 
Sbjct: 38  ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97

Query: 164 FGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTE---RKAAAILALL 220
           F R  CDV+  +DV+ CTASIL+LC IS+DRY  V   + Y     +   R+ A ++  +
Sbjct: 98  FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAV 157

Query: 221 WVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVV 280
           WV+A  VS   L G+      D   C I+    + ++SSV SFYLP  V V++Y R+YVV
Sbjct: 158 WVLAFAVSCPLLFGFN--TTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVV 214

Query: 281 ARSTTR------------SLEAGVKRERGKASEVVLRIH-----CRGAATGADG------ 317
            +   R            S+  G  ++        L +      C+  A G  G      
Sbjct: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274

Query: 318 ----AHGMRSAKGHTFRSSLSVRLLKFS--------------------REKKAAKTLAIV 353
                   R++   T    LS+ + K S                    REKKA + +AIV
Sbjct: 275 ELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIV 334

Query: 354 VGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAF 413
           +G F++CW PFF    L +       S  ++    WLGY NS +NP+IY   + EF++AF
Sbjct: 335 LGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAF 394

Query: 414 LRLLRC 419
           L++L C
Sbjct: 395 LKILSC 400


>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
          Length = 414

 Score =  192 bits (489), Expect = 5e-49
 Identities = 126/379 (33%), Positives = 195/379 (51%), Gaps = 67/379 (17%)

Query: 103 LAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFW 162
           L   I + V GN+LV ++V+  + LQT TNY IV+LAVADLL++  V+P+   +EV+G W
Sbjct: 41  LTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEW 100

Query: 163 AFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKY-PAIMTERKAAAILALLW 221
            F R  CD++  +DV+ CTASIL+LC IS+DRY  V   + Y     ++R+   +++++W
Sbjct: 101 KFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVW 160

Query: 222 VVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVA 281
           V++  +S   L G       D+  C I   A + V+SS+ SFY+P  V +++Y ++Y+V 
Sbjct: 161 VLSFTISCPLLFGLNN---ADQNECIIANPA-FVVYSSIVSFYVPFIVTLLVYIKIYIVL 216

Query: 282 R------STTRS-------LEAGVKRERGKASEVVLRI----------------HCRGAA 312
           R      +T RS       L A +K    +A E+ + +                      
Sbjct: 217 RRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQL 276

Query: 313 TGADGA-HGMRS-------------AKGH------------------TFRSSLSVRLLKF 340
           T  D + HG+ S             AK H                  T   ++S R L  
Sbjct: 277 TLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQ 336

Query: 341 SREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPL 400
            +EKKA + LAIV+GVF++CW P FF+  + ++         ++    WLGY NS VNP+
Sbjct: 337 QKEKKATQMLAIVLGVFIICWLP-FFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPI 395

Query: 401 IYPCSSREFKRAFLRLLRC 419
           IY   + EF++AFL++L C
Sbjct: 396 IYTTFNIEFRKAFLKILHC 414


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  191 bits (486), Expect = 1e-48
 Identities = 117/374 (31%), Positives = 191/374 (51%), Gaps = 28/374 (7%)

Query: 65  NRSSAGEPGSAGAGGDVNGTA---AVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSV 121
           N+S+ G P  A +   +N T    A     + A  + + V L+   L  V  N  V+ ++
Sbjct: 5   NQSAEGLPQEA-SNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTI 63

Query: 122 ACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCT 181
              R L T  NY I +LA  DLL+S  V+P S    +   W FG+  CD+W + D+ CCT
Sbjct: 64  LLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCT 123

Query: 182 ASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPP 241
           ASIL LC I++DRY  +  +L+Y    T   AA ++A++W +++ +S+ PL  W++    
Sbjct: 124 ASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQ 182

Query: 242 DERF-CGI-TEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARS-------------TTR 286
           +E   C + T +  Y ++S+  +FY+P  +++++Y R+Y  AR+             TT 
Sbjct: 183 EEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTA 242

Query: 287 SLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKA 346
            L  G          +   +H  G +  A         K     S+L  + +  +RE+KA
Sbjct: 243 HLITG--SAGSSLCSLNSSLH-EGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKA 299

Query: 347 AKTLAIVVGVFVLCWFPFF---FVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYP 403
            K L I++G F++CW PFF    VLP+      + P+  +F    WLGY NS +NP+IY 
Sbjct: 300 TKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPIIYT 357

Query: 404 CSSREFKRAFLRLL 417
             + EF++AF +++
Sbjct: 358 VFNEEFRQAFQKIV 371


>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
          Length = 378

 Score =  188 bits (477), Expect = 1e-47
 Identities = 132/387 (34%), Positives = 189/387 (48%), Gaps = 47/387 (12%)

Query: 93  SAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTV-TNYFIVNLAVADLLLSATVLP 151
           S + V +  FL+  ILMA+ GNLLV+++V  +R L+ + TNYFIV+LA ADLL+S  V+P
Sbjct: 16  SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75

Query: 152 FSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGV-RHSLKYPAIMTE 210
           F A   V   W +G  FC V  ++DVL  TASI  LC IS+DRY  +    L Y   MT 
Sbjct: 76  FGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTP 135

Query: 211 RKAAAILALLWVVALVVSVGPLL-GW------------KEPVPPDERFCGITEEAGYAVF 257
            + A +L   WV+   +S  P++ GW            K     +  +C       YA+ 
Sbjct: 136 LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAIT 195

Query: 258 SSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADG 317
            SV +FY+P  ++V+ Y R+YV A+     ++  + +  G +SE       R  +     
Sbjct: 196 CSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ--MLQRAGASSE------SRPQSADQHS 247

Query: 318 AHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQL 377
            H MR+                   E KAAKTL I++G F LCW PFF    +       
Sbjct: 248 THRMRT-------------------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT 288

Query: 378 KPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHH 437
            P + V+    WLGY NS +NP +Y   ++ F+RAFL +L C   R RR      + G  
Sbjct: 289 VPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP----SILGQT 343

Query: 438 WRASTSGLRQDCAPSSGDAPPGAPLAL 464
              ST+ +       SG +P  + L L
Sbjct: 344 VPCSTTTINGSTHVLSGCSPVSSFLLL 370


>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
          Length = 359

 Score =  187 bits (476), Expect = 2e-47
 Identities = 124/349 (35%), Positives = 176/349 (50%), Gaps = 43/349 (12%)

Query: 93  SAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTV-TNYFIVNLAVADLLLSATVLP 151
           S + V +  FL+  ILMA+ GNLLV+++V  +R L+ + TNYFIV+LA ADLL+S  V+P
Sbjct: 16  SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75

Query: 152 FSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGV-RHSLKYPAIMTE 210
           F A   V   W +G  FC V  ++DVL  TASI  LC IS+DRY  +    L Y   MT 
Sbjct: 76  FGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTP 135

Query: 211 RKAAAILALLWVVALVVSVGPLL-GW------------KEPVPPDERFCGITEEAGYAVF 257
            + A +L   WV+   +S  P++ GW            K     +  +C       YA+ 
Sbjct: 136 LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAIT 195

Query: 258 SSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADG 317
            SV +FY+P  ++V+ Y R+YV A+     ++  + +  G +SE       R  +     
Sbjct: 196 CSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ--MLQRAGASSE------SRPQSADQHS 247

Query: 318 AHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQL 377
            H MR+                   E KAAKTL I++G F LCW PFF    +       
Sbjct: 248 THRMRT-------------------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT 288

Query: 378 KPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
            P + V+    WLGY NS +NP +Y   ++ F+RAFL +L C   R RR
Sbjct: 289 VPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336


>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
          Length = 428

 Score =  187 bits (476), Expect = 2e-47
 Identities = 124/349 (35%), Positives = 176/349 (50%), Gaps = 43/349 (12%)

Query: 93  SAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTV-TNYFIVNLAVADLLLSATVLP 151
           S + V +  FL+  ILMA+ GNLLV+++V  +R L+ + TNYFIV+LA ADLL+S  V+P
Sbjct: 16  SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75

Query: 152 FSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGV-RHSLKYPAIMTE 210
           F A   V   W +G  FC V  ++DVL  TASI  LC IS+DRY  +    L Y   MT 
Sbjct: 76  FGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTP 135

Query: 211 RKAAAILALLWVVALVVSVGPLL-GW------------KEPVPPDERFCGITEEAGYAVF 257
            + A +L   WV+   +S  P++ GW            K     +  +C       YA+ 
Sbjct: 136 LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAIT 195

Query: 258 SSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADG 317
            SV +FY+P  ++V+ Y R+YV A+     ++  + +  G +SE       R  +     
Sbjct: 196 CSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ--MLQRAGASSE------SRPQSADQHS 247

Query: 318 AHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQL 377
            H MR+                   E KAAKTL I++G F LCW PFF    +       
Sbjct: 248 THRMRT-------------------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT 288

Query: 378 KPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
            P + V+    WLGY NS +NP +Y   ++ F+RAFL +L C   R RR
Sbjct: 289 VPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336


>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
          Length = 360

 Score =  187 bits (476), Expect = 2e-47
 Identities = 124/349 (35%), Positives = 176/349 (50%), Gaps = 43/349 (12%)

Query: 93  SAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTV-TNYFIVNLAVADLLLSATVLP 151
           S + V +  FL+  ILMA+ GNLLV+++V  +R L+ + TNYFIV+LA ADLL+S  V+P
Sbjct: 16  SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75

Query: 152 FSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGV-RHSLKYPAIMTE 210
           F A   V   W +G  FC V  ++DVL  TASI  LC IS+DRY  +    L Y   MT 
Sbjct: 76  FGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTP 135

Query: 211 RKAAAILALLWVVALVVSVGPLL-GW------------KEPVPPDERFCGITEEAGYAVF 257
            + A +L   WV+   +S  P++ GW            K     +  +C       YA+ 
Sbjct: 136 LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAIT 195

Query: 258 SSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADG 317
            SV +FY+P  ++V+ Y R+YV A+     ++  + +  G +SE       R  +     
Sbjct: 196 CSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ--MLQRAGASSE------SRPQSADQHS 247

Query: 318 AHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQL 377
            H MR+                   E KAAKTL I++G F LCW PFF    +       
Sbjct: 248 THRMRT-------------------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT 288

Query: 378 KPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
            P + V+    WLGY NS +NP +Y   ++ F+RAFL +L C   R RR
Sbjct: 289 VPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336


>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
          Length = 387

 Score =  187 bits (476), Expect = 2e-47
 Identities = 124/349 (35%), Positives = 176/349 (50%), Gaps = 43/349 (12%)

Query: 93  SAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTV-TNYFIVNLAVADLLLSATVLP 151
           S + V +  FL+  ILMA+ GNLLV+++V  +R L+ + TNYFIV+LA ADLL+S  V+P
Sbjct: 16  SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75

Query: 152 FSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGV-RHSLKYPAIMTE 210
           F A   V   W +G  FC V  ++DVL  TASI  LC IS+DRY  +    L Y   MT 
Sbjct: 76  FGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTP 135

Query: 211 RKAAAILALLWVVALVVSVGPLL-GW------------KEPVPPDERFCGITEEAGYAVF 257
            + A +L   WV+   +S  P++ GW            K     +  +C       YA+ 
Sbjct: 136 LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAIT 195

Query: 258 SSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADG 317
            SV +FY+P  ++V+ Y R+YV A+     ++  + +  G +SE       R  +     
Sbjct: 196 CSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ--MLQRAGASSE------SRPQSADQHS 247

Query: 318 AHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQL 377
            H MR+                   E KAAKTL I++G F LCW PFF    +       
Sbjct: 248 THRMRT-------------------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT 288

Query: 378 KPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
            P + V+    WLGY NS +NP +Y   ++ F+RAFL +L C   R RR
Sbjct: 289 VPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336


>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
          Length = 388

 Score =  187 bits (476), Expect = 2e-47
 Identities = 124/349 (35%), Positives = 176/349 (50%), Gaps = 43/349 (12%)

Query: 93  SAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTV-TNYFIVNLAVADLLLSATVLP 151
           S + V +  FL+  ILMA+ GNLLV+++V  +R L+ + TNYFIV+LA ADLL+S  V+P
Sbjct: 16  SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75

Query: 152 FSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGV-RHSLKYPAIMTE 210
           F A   V   W +G  FC V  ++DVL  TASI  LC IS+DRY  +    L Y   MT 
Sbjct: 76  FGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTP 135

Query: 211 RKAAAILALLWVVALVVSVGPLL-GW------------KEPVPPDERFCGITEEAGYAVF 257
            + A +L   WV+   +S  P++ GW            K     +  +C       YA+ 
Sbjct: 136 LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAIT 195

Query: 258 SSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADG 317
            SV +FY+P  ++V+ Y R+YV A+     ++  + +  G +SE       R  +     
Sbjct: 196 CSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ--MLQRAGASSE------SRPQSADQHS 247

Query: 318 AHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQL 377
            H MR+                   E KAAKTL I++G F LCW PFF    +       
Sbjct: 248 THRMRT-------------------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT 288

Query: 378 KPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
            P + V+    WLGY NS +NP +Y   ++ F+RAFL +L C   R RR
Sbjct: 289 VPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,997,132
Number of Sequences: 37866
Number of extensions: 1327171
Number of successful extensions: 33872
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1052
Number of HSP's successfully gapped in prelim test: 616
Number of HSP's that attempted gapping in prelim test: 13735
Number of HSP's gapped (non-prelim): 10823
length of query: 572
length of database: 18,247,518
effective HSP length: 108
effective length of query: 464
effective length of database: 14,157,990
effective search space: 6569307360
effective search space used: 6569307360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.