BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens] (318 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens] 632 0.0 gi|115305569 adenosine A1 receptor [Homo sapiens] 301 4e-82 gi|4501947 adenosine A1 receptor [Homo sapiens] 301 4e-82 gi|5921992 adenosine A2a receptor [Homo sapiens] 244 6e-65 gi|4501951 adenosine A2b receptor [Homo sapiens] 229 2e-60 gi|46559769 adenosine A3 receptor isoform 1 [Homo sapiens] 227 1e-59 gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 123 2e-28 gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 112 4e-25 gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 112 4e-25 gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 112 4e-25 gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 112 4e-25 gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 112 4e-25 gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 112 4e-25 gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 111 7e-25 gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 111 7e-25 gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 110 2e-24 gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 108 5e-24 gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 108 5e-24 gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 108 5e-24 gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 108 5e-24 gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 108 8e-24 gi|4503383 dopamine receptor D1 [Homo sapiens] 103 2e-22 gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 102 3e-22 gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 102 4e-22 gi|4885295 G protein-coupled receptor 12 [Homo sapiens] 100 1e-21 gi|28173558 trace amine associated receptor 6 [Homo sapiens] 100 2e-21 gi|110618256 trace amine associated receptor 9 [Homo sapiens] 100 2e-21 gi|15150803 opsin 4 isoform 1 [Homo sapiens] 100 3e-21 gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 99 4e-21 gi|71999131 opsin 3 [Homo sapiens] 99 5e-21 >gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens] Length = 318 Score = 632 bits (1631), Expect = 0.0 Identities = 318/318 (100%), Positives = 318/318 (100%) Query: 1 MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA 60 MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA Sbjct: 1 MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA 60 Query: 61 VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR 120 VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR Sbjct: 61 VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR 120 Query: 121 VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF 180 VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF Sbjct: 121 VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF 180 Query: 181 SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA 240 SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA Sbjct: 181 SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA 240 Query: 241 LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC 300 LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC Sbjct: 241 LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC 300 Query: 301 VVCHPSDSLDTSIEKNSE 318 VVCHPSDSLDTSIEKNSE Sbjct: 301 VVCHPSDSLDTSIEKNSE 318 >gi|115305569 adenosine A1 receptor [Homo sapiens] Length = 326 Score = 301 bits (772), Expect = 4e-82 Identities = 153/316 (48%), Positives = 217/316 (68%), Gaps = 9/316 (2%) Query: 7 ALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVM 66 ++S YI +E+ I L ++ GNVLVI VK+N +L+ TF FIVSLA+AD+AVG LV+ Sbjct: 4 SISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVI 63 Query: 67 PLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRR 126 PLAI++++G +F++CL + C +LI T +SI++LLAIAVDRYLRVK+ +RYK V T RR Sbjct: 64 PLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRR 123 Query: 127 IWLALGLCWLVSFLVGLTPMFGWNMKLTSEY------HRNVTFLSCQFVSVMRMDYMVYF 180 +A+ CW++SF+VGLTPMFGWN E + C+F V+ M+YMVYF Sbjct: 124 AAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYF 183 Query: 181 SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLS-NSKETGAFYGREFKTAKSLFLVLFLF 239 +F W+ PL++M IYL++FY+IR +L+ +S +S + +YG+E K AKSL L+LFLF Sbjct: 184 NFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLF 243 Query: 240 ALSWLPLSIINCIIYF--NGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLIL 297 ALSWLPL I+NCI F + P ++ Y+ I L+H NS MNPIVYA++I+KF+ T+L I Sbjct: 244 ALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIW 303 Query: 298 KACVVCHPSDSLDTSI 313 C P+ +D + Sbjct: 304 NDHFRCQPAPPIDEDL 319 >gi|4501947 adenosine A1 receptor [Homo sapiens] Length = 326 Score = 301 bits (772), Expect = 4e-82 Identities = 153/316 (48%), Positives = 217/316 (68%), Gaps = 9/316 (2%) Query: 7 ALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVM 66 ++S YI +E+ I L ++ GNVLVI VK+N +L+ TF FIVSLA+AD+AVG LV+ Sbjct: 4 SISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVI 63 Query: 67 PLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRR 126 PLAI++++G +F++CL + C +LI T +SI++LLAIAVDRYLRVK+ +RYK V T RR Sbjct: 64 PLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRR 123 Query: 127 IWLALGLCWLVSFLVGLTPMFGWNMKLTSEY------HRNVTFLSCQFVSVMRMDYMVYF 180 +A+ CW++SF+VGLTPMFGWN E + C+F V+ M+YMVYF Sbjct: 124 AAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYF 183 Query: 181 SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLS-NSKETGAFYGREFKTAKSLFLVLFLF 239 +F W+ PL++M IYL++FY+IR +L+ +S +S + +YG+E K AKSL L+LFLF Sbjct: 184 NFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLF 243 Query: 240 ALSWLPLSIINCIIYF--NGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLIL 297 ALSWLPL I+NCI F + P ++ Y+ I L+H NS MNPIVYA++I+KF+ T+L I Sbjct: 244 ALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIW 303 Query: 298 KACVVCHPSDSLDTSI 313 C P+ +D + Sbjct: 304 NDHFRCQPAPPIDEDL 319 >gi|5921992 adenosine A2a receptor [Homo sapiens] Length = 412 Score = 244 bits (624), Expect = 6e-65 Identities = 127/305 (41%), Positives = 192/305 (62%), Gaps = 12/305 (3%) Query: 10 LANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLA 69 + + YIT+E+ I + AI+GNVLV V LN +LQ T YF+VSLA ADIAVGVL +P A Sbjct: 4 MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA 63 Query: 70 IVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWL 129 I +S G + CLF+ C +L+ T +SI SLLAIA+DRY+ +++ +RY + T R Sbjct: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 Query: 130 ALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVT------FLSCQFVSVMRMDYMVYFSFL 183 + +CW++SF +GLTPM GWN + +N + ++C F V+ M+YMVYF+F Sbjct: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFF 183 Query: 184 TWIFIPLVVMCAIYLDIFYIIRNKLSLNLSN---SKETGAFYGREFKTAKSLFLVLFLFA 240 + +PL++M +YL IF R +L S + + +E AKSL +++ LFA Sbjct: 184 ACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFA 243 Query: 241 LSWLPLSIINCIIYF---NGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLIL 297 L WLPL IINC +F P ++Y+ I+LSH NS++NP +YAY+I++F++T+ I+ Sbjct: 244 LCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 Query: 298 KACVV 302 ++ V+ Sbjct: 304 RSHVL 308 >gi|4501951 adenosine A2b receptor [Homo sapiens] Length = 332 Score = 229 bits (584), Expect = 2e-60 Identities = 122/312 (39%), Positives = 184/312 (58%), Gaps = 19/312 (6%) Query: 8 LSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMP 67 L + Y+ +E+ I ++ GNVLV V +LQT T YF+VSLA AD+AVG+ +P Sbjct: 3 LETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIP 62 Query: 68 LAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRI 127 AI +SLG FY CLF+ C +L+ T +SI SLLA+AVDRYL + + +RYK + T R Sbjct: 63 FAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRA 122 Query: 128 WLALGLCWLVSFLVGLTPMFGWNMKLTS----------EYHRNVTFLSCQFVSVMRMDYM 177 + + W+++F +GLTP GWN K ++ + + + C F +V+ M YM Sbjct: 123 RGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYM 182 Query: 178 VYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLN--LSNSKETGAFYGREFKTAKSLFLV 235 VYF+F + PL++M IY+ IF + +L + +S+ T RE AKSL ++ Sbjct: 183 VYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTT---LQREIHAAKSLAMI 239 Query: 236 LFLFALSWLPLSIINCIIYF----NGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKE 291 + +FAL WLP+ +NC+ F P+ + M ILLSHANS++NPIVYAY+ + F+ Sbjct: 240 VGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRY 299 Query: 292 TYLLILKACVVC 303 T+ I+ ++C Sbjct: 300 TFHKIISRYLLC 311 >gi|46559769 adenosine A3 receptor isoform 1 [Homo sapiens] Length = 347 Score = 227 bits (578), Expect = 1e-59 Identities = 117/119 (98%), Positives = 119/119 (100%) Query: 1 MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA 60 MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA Sbjct: 1 MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA 60 Query: 61 VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYK 119 VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVR++ Sbjct: 61 VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRFR 119 >gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] Length = 520 Score = 123 bits (309), Expect = 2e-28 Identities = 101/346 (29%), Positives = 160/346 (46%), Gaps = 60/346 (17%) Query: 2 PNNSTALSLANVTYITMEIFIGLC-------AIVGNVLVICVVKLNPSLQTTTFYFIVSL 54 PN +++ S IT I +GL AIVGN+LVI V N L+T T YFIV+L Sbjct: 28 PNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNL 87 Query: 55 ALADIAVGVLVMPLAIVVS-LGI-TIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRV 112 A+AD+ + V+P + + LG + C + ++ ASI+SL AI++DRY+ V Sbjct: 88 AMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGV 147 Query: 113 KLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVM 172 + +++Y + T R+ LAL W++S ++ + P+ GW ++ V Sbjct: 148 RYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKE---------CGVT 198 Query: 173 RMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNL--------SNSKETGA---- 220 + FS L +IPL V+ +Y + YI+ + + NL SNSKE Sbjct: 199 EEPFYALFSSLGSFYIPLAVILVMYCRV-YIVAKRTTKNLEAGVMKEMSNSKELTLRIHS 257 Query: 221 ---------------------------FYGREFKTAKSLFLVLFLFALSWLPLSIINCI- 252 + RE K AK+L +V+ +F L WLP I + Sbjct: 258 KNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLG 317 Query: 253 -IYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLIL 297 ++ + P V + L + NS +NPI+Y K+FK ++ IL Sbjct: 318 SLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRIL 363 >gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] Length = 359 Score = 112 bits (280), Expect = 4e-25 Identities = 97/315 (30%), Positives = 148/315 (46%), Gaps = 29/315 (9%) Query: 9 SLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTT-TFYFIVSLALADIAVGVLVMP 67 S+ V +T + L AI+GN+LV+ V + L+ T YFIVSLA AD+ V VLVMP Sbjct: 16 SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75 Query: 68 LAIVVSLGITIHFYS---CLFMTCLLLIFTHASIMSLLAIAVDRYLRVKL-TVRYKRVTT 123 + L I Y CL T L ++ T ASI L I++DRY + + Y+ T Sbjct: 76 FG-AIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134 Query: 124 HRRIWLALGLCWLVSFLVGLTP-MFGWN----MKLTSEYHRNVTFLSCQFVSVMRMDYMV 178 RI L LG CW++ + P M GWN + L + N S V ++ Y + Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194 Query: 179 YFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAF---------------YG 223 S + + +IP ++M Y I Y+ + + + + GA Sbjct: 195 TCSVVAF-YIPFLLMVLAYYRI-YVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMR 252 Query: 224 REFKTAKSLFLVLFLFALSWLPLSIINCI-IYFNGEVPQLVLYMGILLSHANSMMNPIVY 282 E K AK+L +++ F L W P + N + + + VP V + L + NS +NP +Y Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312 Query: 283 AYKIKKFKETYLLIL 297 A+ K F+ +L+IL Sbjct: 313 AFLNKSFRRAFLIIL 327 >gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] Length = 428 Score = 112 bits (280), Expect = 4e-25 Identities = 97/315 (30%), Positives = 148/315 (46%), Gaps = 29/315 (9%) Query: 9 SLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTT-TFYFIVSLALADIAVGVLVMP 67 S+ V +T + L AI+GN+LV+ V + L+ T YFIVSLA AD+ V VLVMP Sbjct: 16 SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75 Query: 68 LAIVVSLGITIHFYS---CLFMTCLLLIFTHASIMSLLAIAVDRYLRVKL-TVRYKRVTT 123 + L I Y CL T L ++ T ASI L I++DRY + + Y+ T Sbjct: 76 FG-AIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134 Query: 124 HRRIWLALGLCWLVSFLVGLTP-MFGWN----MKLTSEYHRNVTFLSCQFVSVMRMDYMV 178 RI L LG CW++ + P M GWN + L + N S V ++ Y + Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194 Query: 179 YFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAF---------------YG 223 S + + +IP ++M Y I Y+ + + + + GA Sbjct: 195 TCSVVAF-YIPFLLMVLAYYRI-YVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMR 252 Query: 224 REFKTAKSLFLVLFLFALSWLPLSIINCI-IYFNGEVPQLVLYMGILLSHANSMMNPIVY 282 E K AK+L +++ F L W P + N + + + VP V + L + NS +NP +Y Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312 Query: 283 AYKIKKFKETYLLIL 297 A+ K F+ +L+IL Sbjct: 313 AFLNKSFRRAFLIIL 327 >gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] Length = 360 Score = 112 bits (280), Expect = 4e-25 Identities = 97/315 (30%), Positives = 148/315 (46%), Gaps = 29/315 (9%) Query: 9 SLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTT-TFYFIVSLALADIAVGVLVMP 67 S+ V +T + L AI+GN+LV+ V + L+ T YFIVSLA AD+ V VLVMP Sbjct: 16 SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75 Query: 68 LAIVVSLGITIHFYS---CLFMTCLLLIFTHASIMSLLAIAVDRYLRVKL-TVRYKRVTT 123 + L I Y CL T L ++ T ASI L I++DRY + + Y+ T Sbjct: 76 FG-AIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134 Query: 124 HRRIWLALGLCWLVSFLVGLTP-MFGWN----MKLTSEYHRNVTFLSCQFVSVMRMDYMV 178 RI L LG CW++ + P M GWN + L + N S V ++ Y + Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194 Query: 179 YFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAF---------------YG 223 S + + +IP ++M Y I Y+ + + + + GA Sbjct: 195 TCSVVAF-YIPFLLMVLAYYRI-YVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMR 252 Query: 224 REFKTAKSLFLVLFLFALSWLPLSIINCI-IYFNGEVPQLVLYMGILLSHANSMMNPIVY 282 E K AK+L +++ F L W P + N + + + VP V + L + NS +NP +Y Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312 Query: 283 AYKIKKFKETYLLIL 297 A+ K F+ +L+IL Sbjct: 313 AFLNKSFRRAFLIIL 327 >gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] Length = 387 Score = 112 bits (280), Expect = 4e-25 Identities = 97/315 (30%), Positives = 148/315 (46%), Gaps = 29/315 (9%) Query: 9 SLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTT-TFYFIVSLALADIAVGVLVMP 67 S+ V +T + L AI+GN+LV+ V + L+ T YFIVSLA AD+ V VLVMP Sbjct: 16 SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75 Query: 68 LAIVVSLGITIHFYS---CLFMTCLLLIFTHASIMSLLAIAVDRYLRVKL-TVRYKRVTT 123 + L I Y CL T L ++ T ASI L I++DRY + + Y+ T Sbjct: 76 FG-AIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134 Query: 124 HRRIWLALGLCWLVSFLVGLTP-MFGWN----MKLTSEYHRNVTFLSCQFVSVMRMDYMV 178 RI L LG CW++ + P M GWN + L + N S V ++ Y + Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194 Query: 179 YFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAF---------------YG 223 S + + +IP ++M Y I Y+ + + + + GA Sbjct: 195 TCSVVAF-YIPFLLMVLAYYRI-YVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMR 252 Query: 224 REFKTAKSLFLVLFLFALSWLPLSIINCI-IYFNGEVPQLVLYMGILLSHANSMMNPIVY 282 E K AK+L +++ F L W P + N + + + VP V + L + NS +NP +Y Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312 Query: 283 AYKIKKFKETYLLIL 297 A+ K F+ +L+IL Sbjct: 313 AFLNKSFRRAFLIIL 327 >gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] Length = 378 Score = 112 bits (280), Expect = 4e-25 Identities = 97/315 (30%), Positives = 148/315 (46%), Gaps = 29/315 (9%) Query: 9 SLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTT-TFYFIVSLALADIAVGVLVMP 67 S+ V +T + L AI+GN+LV+ V + L+ T YFIVSLA AD+ V VLVMP Sbjct: 16 SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75 Query: 68 LAIVVSLGITIHFYS---CLFMTCLLLIFTHASIMSLLAIAVDRYLRVKL-TVRYKRVTT 123 + L I Y CL T L ++ T ASI L I++DRY + + Y+ T Sbjct: 76 FG-AIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134 Query: 124 HRRIWLALGLCWLVSFLVGLTP-MFGWN----MKLTSEYHRNVTFLSCQFVSVMRMDYMV 178 RI L LG CW++ + P M GWN + L + N S V ++ Y + Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194 Query: 179 YFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAF---------------YG 223 S + + +IP ++M Y I Y+ + + + + GA Sbjct: 195 TCSVVAF-YIPFLLMVLAYYRI-YVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMR 252 Query: 224 REFKTAKSLFLVLFLFALSWLPLSIINCI-IYFNGEVPQLVLYMGILLSHANSMMNPIVY 282 E K AK+L +++ F L W P + N + + + VP V + L + NS +NP +Y Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312 Query: 283 AYKIKKFKETYLLIL 297 A+ K F+ +L+IL Sbjct: 313 AFLNKSFRRAFLIIL 327 >gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] Length = 388 Score = 112 bits (280), Expect = 4e-25 Identities = 97/315 (30%), Positives = 148/315 (46%), Gaps = 29/315 (9%) Query: 9 SLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTT-TFYFIVSLALADIAVGVLVMP 67 S+ V +T + L AI+GN+LV+ V + L+ T YFIVSLA AD+ V VLVMP Sbjct: 16 SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75 Query: 68 LAIVVSLGITIHFYS---CLFMTCLLLIFTHASIMSLLAIAVDRYLRVKL-TVRYKRVTT 123 + L I Y CL T L ++ T ASI L I++DRY + + Y+ T Sbjct: 76 FG-AIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134 Query: 124 HRRIWLALGLCWLVSFLVGLTP-MFGWN----MKLTSEYHRNVTFLSCQFVSVMRMDYMV 178 RI L LG CW++ + P M GWN + L + N S V ++ Y + Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194 Query: 179 YFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAF---------------YG 223 S + + +IP ++M Y I Y+ + + + + GA Sbjct: 195 TCSVVAF-YIPFLLMVLAYYRI-YVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMR 252 Query: 224 REFKTAKSLFLVLFLFALSWLPLSIINCI-IYFNGEVPQLVLYMGILLSHANSMMNPIVY 282 E K AK+L +++ F L W P + N + + + VP V + L + NS +NP +Y Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312 Query: 283 AYKIKKFKETYLLIL 297 A+ K F+ +L+IL Sbjct: 313 AFLNKSFRRAFLIIL 327 >gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] Length = 397 Score = 111 bits (278), Expect = 7e-25 Identities = 95/325 (29%), Positives = 156/325 (48%), Gaps = 27/325 (8%) Query: 4 NSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGV 63 +STA + + + I I + GNV+V V LN L+ T FIVSLA+ D+ +G+ Sbjct: 13 DSTACKITITVVLAVLILI---TVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGL 69 Query: 64 LVMPLAIVVSLGITIHF--YSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRV 121 LV+P + + L F C T L ++ ASI++L I++DRY V +RY + Sbjct: 70 LVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVL 129 Query: 122 TTHRRIWLALGLCWLVSFLVG-LTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF 180 T R+ ++L L W++S + L+ GWN + N T C+ V V + +V Sbjct: 130 VTPVRVAISLVLIWVISITLSFLSIHLGWNSR-NETSKGNHTTSKCK-VQVNEVYGLV-- 185 Query: 181 SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA 240 L ++PL++MC Y IF + R++ + +++ A RE K +L V+ F Sbjct: 186 DGLVTFYLPLLIMCITYYRIFKVARDQ-AKRINHISSWKAATIREHKATVTLAAVMGAFI 244 Query: 241 LSWLPLSIINCIIY--------FNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKET 292 + W P +Y N + +VL++G +ANS +NPI+YA + F+ Sbjct: 245 ICWFP--YFTAFVYRGLRGDDAINEVLEAIVLWLG----YANSALNPILYAALNRDFRTG 298 Query: 293 YLLILKACVVCHPSDSLDTSIEKNS 317 Y + C +S TS+ N+ Sbjct: 299 YQQLF--CCRLANRNSHKTSLRSNA 321 >gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] Length = 359 Score = 111 bits (278), Expect = 7e-25 Identities = 95/325 (29%), Positives = 156/325 (48%), Gaps = 27/325 (8%) Query: 4 NSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGV 63 +STA + + + I I + GNV+V V LN L+ T FIVSLA+ D+ +G+ Sbjct: 13 DSTACKITITVVLAVLILI---TVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGL 69 Query: 64 LVMPLAIVVSLGITIHF--YSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRV 121 LV+P + + L F C T L ++ ASI++L I++DRY V +RY + Sbjct: 70 LVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVL 129 Query: 122 TTHRRIWLALGLCWLVSFLVG-LTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF 180 T R+ ++L L W++S + L+ GWN + N T C+ V V + +V Sbjct: 130 VTPVRVAISLVLIWVISITLSFLSIHLGWNSR-NETSKGNHTTSKCK-VQVNEVYGLV-- 185 Query: 181 SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA 240 L ++PL++MC Y IF + R++ + +++ A RE K +L V+ F Sbjct: 186 DGLVTFYLPLLIMCITYYRIFKVARDQ-AKRINHISSWKAATIREHKATVTLAAVMGAFI 244 Query: 241 LSWLPLSIINCIIY--------FNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKET 292 + W P +Y N + +VL++G +ANS +NPI+YA + F+ Sbjct: 245 ICWFP--YFTAFVYRGLRGDDAINEVLEAIVLWLG----YANSALNPILYAALNRDFRTG 298 Query: 293 YLLILKACVVCHPSDSLDTSIEKNS 317 Y + C +S TS+ N+ Sbjct: 299 YQQLF--CCRLANRNSHKTSLRSNA 321 >gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] Length = 572 Score = 110 bits (274), Expect = 2e-24 Identities = 83/326 (25%), Positives = 145/326 (44%), Gaps = 66/326 (20%) Query: 24 LCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYS- 82 L A+ GN+LVI V N LQT T YFIV+LA+AD+ + V+P + + + + F++ Sbjct: 108 LMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEV---LGFWAF 164 Query: 83 ----CLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVS 138 C + ++ ASI+SL I+VDRY+ V+ +++Y + T R+ L L W+V+ Sbjct: 165 GRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVA 224 Query: 139 FLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYL 198 +V + P+ GW + + +F + FS + ++P+ V+ +Y Sbjct: 225 LVVSVGPLLGWKEPVPPDE---------RFCGITEEAGYAVFSSVCSFYLPMAVIVVMYC 275 Query: 199 DIFYIIRNKL-SLNLSNSKETGAF------------------------------------ 221 ++ + R+ SL +E G Sbjct: 276 RVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSV 335 Query: 222 ----YGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGIL-----LSH 272 + RE K AK+L +V+ +F L W P ++ PQL G+ L + Sbjct: 336 RLLKFSREKKAAKTLAIVVGVFVLCWFPFFF---VLPLGSLFPQLKPSEGVFKVIFWLGY 392 Query: 273 ANSMMNPIVYAYKIKKFKETYLLILK 298 NS +NP++Y ++FK +L +L+ Sbjct: 393 FNSCVNPLIYPCSSREFKRAFLRLLR 418 >gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] Length = 455 Score = 108 bits (271), Expect = 5e-24 Identities = 85/324 (26%), Positives = 146/324 (45%), Gaps = 48/324 (14%) Query: 24 LCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPL-AIVVSLGI-TIHFY 81 L ++GN+LVI V + L + T Y+IV+LA+AD+ + V+P AI LG Sbjct: 38 LFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRV 97 Query: 82 SCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLV 141 C + ++ ASIM L I++DRY+ V +RY + T RR +AL W +S ++ Sbjct: 98 FCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVI 157 Query: 142 GLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIF 201 + P+FGW + CQ + V FS L ++PL ++ +Y ++ Sbjct: 158 SIGPLFGWRQPAPEDE------TICQ---INEEPGYVLFSALGSFYLPLAIILVMYCRVY 208 Query: 202 YIIRNK-------------------LSLNLSNSKETGA----------------FYGREF 226 + + + L ++ N+ G+ + RE Sbjct: 209 VVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREK 268 Query: 227 KTAKSLFLVLFLFALSWLPLSIINCIIYF--NGEVPQLVLYMGILLSHANSMMNPIVYAY 284 K AK+L +V+ F L WLP ++ I F + + + V + L + NS +NPI+Y Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPC 328 Query: 285 KIKKFKETYLLILKACVVCHPSDS 308 ++FK+ + +L+ +C S Sbjct: 329 SSQEFKKAFQNVLRIQCLCRKQSS 352 >gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] Length = 466 Score = 108 bits (271), Expect = 5e-24 Identities = 85/324 (26%), Positives = 146/324 (45%), Gaps = 48/324 (14%) Query: 24 LCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPL-AIVVSLGI-TIHFY 81 L ++GN+LVI V + L + T Y+IV+LA+AD+ + V+P AI LG Sbjct: 38 LFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRV 97 Query: 82 SCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLV 141 C + ++ ASIM L I++DRY+ V +RY + T RR +AL W +S ++ Sbjct: 98 FCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVI 157 Query: 142 GLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIF 201 + P+FGW + CQ + V FS L ++PL ++ +Y ++ Sbjct: 158 SIGPLFGWRQPAPEDE------TICQ---INEEPGYVLFSALGSFYLPLAIILVMYCRVY 208 Query: 202 YIIRNK-------------------LSLNLSNSKETGA----------------FYGREF 226 + + + L ++ N+ G+ + RE Sbjct: 209 VVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREK 268 Query: 227 KTAKSLFLVLFLFALSWLPLSIINCIIYF--NGEVPQLVLYMGILLSHANSMMNPIVYAY 284 K AK+L +V+ F L WLP ++ I F + + + V + L + NS +NPI+Y Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPC 328 Query: 285 KIKKFKETYLLILKACVVCHPSDS 308 ++FK+ + +L+ +C S Sbjct: 329 SSQEFKKAFQNVLRIQCLCRKQSS 352 >gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] Length = 475 Score = 108 bits (271), Expect = 5e-24 Identities = 85/324 (26%), Positives = 146/324 (45%), Gaps = 48/324 (14%) Query: 24 LCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPL-AIVVSLGI-TIHFY 81 L ++GN+LVI V + L + T Y+IV+LA+AD+ + V+P AI LG Sbjct: 38 LFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRV 97 Query: 82 SCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLV 141 C + ++ ASIM L I++DRY+ V +RY + T RR +AL W +S ++ Sbjct: 98 FCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVI 157 Query: 142 GLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIF 201 + P+FGW + CQ + V FS L ++PL ++ +Y ++ Sbjct: 158 SIGPLFGWRQPAPEDE------TICQ---INEEPGYVLFSALGSFYLPLAIILVMYCRVY 208 Query: 202 YIIRNK-------------------LSLNLSNSKETGA----------------FYGREF 226 + + + L ++ N+ G+ + RE Sbjct: 209 VVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREK 268 Query: 227 KTAKSLFLVLFLFALSWLPLSIINCIIYF--NGEVPQLVLYMGILLSHANSMMNPIVYAY 284 K AK+L +V+ F L WLP ++ I F + + + V + L + NS +NPI+Y Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPC 328 Query: 285 KIKKFKETYLLILKACVVCHPSDS 308 ++FK+ + +L+ +C S Sbjct: 329 SSQEFKKAFQNVLRIQCLCRKQSS 352 >gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] Length = 429 Score = 108 bits (271), Expect = 5e-24 Identities = 85/324 (26%), Positives = 146/324 (45%), Gaps = 48/324 (14%) Query: 24 LCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPL-AIVVSLGI-TIHFY 81 L ++GN+LVI V + L + T Y+IV+LA+AD+ + V+P AI LG Sbjct: 38 LFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRV 97 Query: 82 SCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLV 141 C + ++ ASIM L I++DRY+ V +RY + T RR +AL W +S ++ Sbjct: 98 FCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVI 157 Query: 142 GLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIF 201 + P+FGW + CQ + V FS L ++PL ++ +Y ++ Sbjct: 158 SIGPLFGWRQPAPEDE------TICQ---INEEPGYVLFSALGSFYLPLAIILVMYCRVY 208 Query: 202 YIIRNK-------------------LSLNLSNSKETGA----------------FYGREF 226 + + + L ++ N+ G+ + RE Sbjct: 209 VVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREK 268 Query: 227 KTAKSLFLVLFLFALSWLPLSIINCIIYF--NGEVPQLVLYMGILLSHANSMMNPIVYAY 284 K AK+L +V+ F L WLP ++ I F + + + V + L + NS +NPI+Y Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPC 328 Query: 285 KIKKFKETYLLILKACVVCHPSDS 308 ++FK+ + +L+ +C S Sbjct: 329 SSQEFKKAFQNVLRIQCLCRKQSS 352 >gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] Length = 402 Score = 108 bits (269), Expect = 8e-24 Identities = 98/329 (29%), Positives = 149/329 (45%), Gaps = 43/329 (13%) Query: 9 SLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTT-TFYFIVSLALADIAVGVLVMP 67 S+ V +T + L AI+GN+LV+ V + L+ T YFIVSLA AD+ V VLVMP Sbjct: 16 SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75 Query: 68 LAIVVSLGITIHFYS---CLFMTCLLLIFTHASIMSLLAIAVDRYLRVKL-TVRYKRVTT 123 + L I Y CL T L ++ T ASI L I++DRY + + Y+ T Sbjct: 76 FG-AIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134 Query: 124 HRRIWLALGLCWLVSFLVGLTP-MFGW------------NMKLTSEYHR------NVTFL 164 RI L LG CW++ + P M GW N L ++H N Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDFHAIEKRKFNQNSN 194 Query: 165 SCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAF--- 221 S V ++ Y + S + + +IP ++M Y I Y+ + + + + GA Sbjct: 195 STYCVFMVNKPYAITCSVVAF-YIPFLLMVLAYYRI-YVTAKEHAHQIQMLQRAGASSES 252 Query: 222 ------------YGREFKTAKSLFLVLFLFALSWLPLSIINCI-IYFNGEVPQLVLYMGI 268 E K AK+L +++ F L W P + N + + + VP V + Sbjct: 253 RPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL 312 Query: 269 LLSHANSMMNPIVYAYKIKKFKETYLLIL 297 L + NS +NP +YA+ K F+ +L+IL Sbjct: 313 WLGYINSGLNPFLYAFLNKSFRRAFLIIL 341 >gi|4503383 dopamine receptor D1 [Homo sapiens] Length = 446 Score = 103 bits (258), Expect = 2e-22 Identities = 85/335 (25%), Positives = 155/335 (46%), Gaps = 45/335 (13%) Query: 24 LCAIVGNVLVIC-VVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYS 82 L ++GN LV V++ T +F++SLA++D+ V VLVMP V + F S Sbjct: 35 LSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS 94 Query: 83 -CLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLV 141 C ++ + ASI++L I+VDRY + RY+R T + ++ + + W +S L+ Sbjct: 95 FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLI 154 Query: 142 GLTPM-FGWNM-KLTSEYHRNVTFLS-----CQFVSVMRMDYMVYFSFLTWIFIPLVVMC 194 P+ W+ K TS N T L+ C S + Y + S +++ +IP+ +M Sbjct: 155 SFIPVQLSWHKAKPTSPSDGNATSLAETIDNCD--SSLSRTYAISSSVISF-YIPVAIMI 211 Query: 195 AIYLDIFYIIRNKL---------SLNLSNSKETGA----------------FYGREFKTA 229 Y I+ I + ++ +++ N + T + RE K Sbjct: 212 VTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVL 271 Query: 230 KSLFLVLFLFALSWLPLSIINCIIYFNGE-------VPQLVLYMGILLSHANSMMNPIVY 282 K+L +++ +F WLP I+NCI+ F G + + + ANS +NPI+Y Sbjct: 272 KTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIY 331 Query: 283 AYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNS 317 A+ F++ + +L +C +++ ++ N+ Sbjct: 332 AFN-ADFRKAFSTLLGCYRLCPATNNAIETVSINN 365 >gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] Length = 408 Score = 102 bits (255), Expect = 3e-22 Identities = 95/326 (29%), Positives = 144/326 (44%), Gaps = 60/326 (18%) Query: 24 LCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHF--- 80 L + GN+LVI + P LQT T F+ SLA AD+ +G+LV+P A +L +T H+ Sbjct: 49 LATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPA--ATLALTGHWPLG 106 Query: 81 -YSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSF 139 C T + ++ ASI +L A+AVDRYL V +RY + T R A+ L W+VS Sbjct: 107 ATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSA 166 Query: 140 LVGLTPMFG--WNMKLTSEYHR-NVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAI 196 V P+ W + +E R + C F S M Y++ S +++ ++PL+VM + Sbjct: 167 AVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFAS--NMPYVLLSSSVSF-YLPLLVMLFV 223 Query: 197 YLDIFYIIRNKLSLNLSNSKETGAFYG--------------------------------- 223 Y +F + +L L E G F Sbjct: 224 YARVFVVATRQLRLLRG---ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPA 280 Query: 224 -----REFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGIL----LSHAN 274 RE + +L L++ F L WLP + N + G P LV L L +AN Sbjct: 281 RLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGG--PSLVPGPAFLALNWLGYAN 338 Query: 275 SMMNPIVYAYKIKKFKETYLLILKAC 300 S NP++Y + F+ + +L C Sbjct: 339 SAFNPLIYC-RSPDFRSAFRRLLCRC 363 >gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] Length = 413 Score = 102 bits (254), Expect = 4e-22 Identities = 81/293 (27%), Positives = 138/293 (47%), Gaps = 30/293 (10%) Query: 16 ITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPL--AIVVS 73 I M + + L + GNVLVI + LQT T YFI SLA AD+ +G+ V+P A ++ Sbjct: 38 IVMSLIV-LAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILM 96 Query: 74 LGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGL 133 T + C F T + ++ ASI +L IAVDRY + +Y+ + T + + + + Sbjct: 97 KMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILM 156 Query: 134 CWLVSFLVGLTPMFGWNMKLTSEYHRN--VTFLSCQFVSVMRMDYMVYFSFLTWIFIPLV 191 W+VS L P+ + T + N C F + Y + S +++ ++PLV Sbjct: 157 VWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFT--NQAYAIASSIVSF-YVPLV 213 Query: 192 VMCAIYLDIFYIIRNKLS-----------LNLSNSKETG----------AFYGREFKTAK 230 +M +Y +F + +L NLS ++ G F +E K K Sbjct: 214 IMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALK 273 Query: 231 SLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGI-LLSHANSMMNPIVY 282 +L +++ F L WLP I+N + + + +Y+ + + + NS NP++Y Sbjct: 274 TLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIY 326 >gi|4885295 G protein-coupled receptor 12 [Homo sapiens] Length = 334 Score = 100 bits (250), Expect = 1e-21 Identities = 70/273 (25%), Positives = 134/273 (49%), Gaps = 15/273 (5%) Query: 30 NVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCL 89 N +V+ ++ NPSL+ F I SLALAD+ G+ ++ + L + + +T Sbjct: 62 NAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYL---LQSEATKLVTIG 118 Query: 90 LLIFTH-ASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFG 148 L++ + AS+ SLLAI VDRYL + + Y T ++ L + W S +GL P+ G Sbjct: 119 LIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMG 178 Query: 149 WNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKL 208 WN V L+ +++ + ++ F+ + ++I + C I ++R+ Sbjct: 179 WNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQI---CKI------VMRHAH 229 Query: 209 SLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGI 268 + L + + Y K +L ++L FA W+P ++ + I + P + Y + Sbjct: 230 QIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYT--YPSIYTYATL 287 Query: 269 LLSHANSMMNPIVYAYKIKKFKETYLLILKACV 301 L + NS++NP++YA++ ++ ++ LI C+ Sbjct: 288 LPATYNSIINPVIYAFRNQEIQKALCLICCGCI 320 >gi|28173558 trace amine associated receptor 6 [Homo sapiens] Length = 345 Score = 100 bits (249), Expect = 2e-21 Identities = 89/309 (28%), Positives = 147/309 (47%), Gaps = 29/309 (9%) Query: 21 FIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHF 80 F + A+ GN+LV+ + L + T + + SLA AD VGV VMP ++V ++ +F Sbjct: 41 FGAVLAVFGNLLVMISILHFKQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESCWYF 100 Query: 81 --YSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVS 138 C F TC + F ++S+ L I++DRY+ V + Y T G+C VS Sbjct: 101 GRSFCTFHTCCDVAFCYSSLFHLCFISIDRYIAVTDPLVYPTKFTVS----VSGICISVS 156 Query: 139 FLVGLTPMFGWNMKLTSEYHRNVTFLS--------CQFVSVMRMDYMVYFSFLTWIFIPL 190 +++ L M+ + T Y + LS CQ V + SF FIP Sbjct: 157 WILPL--MYSGAVFYTGVYDDGLEELSDALNCIGGCQTVVNQNWVLTDFLSF----FIPT 210 Query: 191 VVMCAIYLDIFYIIR---NKLSLNLSNSKETGAFY-----GREFKTAKSLFLVLFLFALS 242 +M +Y +IF + R K+ S ++ + Y RE K AK+L + + F +S Sbjct: 211 FIMIILYGNIFLVARRQAKKIENTGSKTESSSESYKARVARRERKAAKTLGVTVVAFMIS 270 Query: 243 WLPLSIINCIIYFNGEV-PQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACV 301 WLP SI + I F G + P + + ++ NS MNP++YA F++ +I+ V Sbjct: 271 WLPYSIDSLIDAFMGFITPACIYEICCWCAYYNSAMNPLIYALFYPWFRKAIKVIVTGQV 330 Query: 302 VCHPSDSLD 310 + + S +++ Sbjct: 331 LKNSSATMN 339 >gi|110618256 trace amine associated receptor 9 [Homo sapiens] Length = 348 Score = 100 bits (249), Expect = 2e-21 Identities = 92/307 (29%), Positives = 145/307 (47%), Gaps = 21/307 (6%) Query: 21 FIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHF 80 F + A GN+LV+ + L T T + I SLA AD VGV VMP + V S+ +F Sbjct: 41 FGAVLAAFGNLLVMIAILHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYF 100 Query: 81 YS--CLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVS 138 C F TC F AS+ L I+VDRY+ V + Y T + + L W S Sbjct: 101 GDSYCKFHTCFDTSFCFASLFHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFS 160 Query: 139 FLVGLTPMF-GWNMKLTSEYHRNVTFL-SCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAI 196 + + G N + E +T + CQ + + ++++ L FIP V M I Sbjct: 161 VTYSFSIFYTGANEEGIEELVVALTCVGGCQ--APLNQNWVLLCFLL--FFIPNVAMVFI 216 Query: 197 YLDIFYIIRN---KLSLNLSNSKETGAFY-----GREFKTAKSLFLVLFLFALSWLPLSI 248 Y IF + ++ K+ S ++ + Y RE K AK+L + + F +SWLP + Sbjct: 217 YSKIFLVAKHQARKIESTASQAQSSSESYKERVAKRERKAAKTLGIAMAAFLVSWLPY-L 275 Query: 249 INCII--YFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPS 306 ++ +I Y N P V + + + NS MNP++YA+ + F + LI+ V+ + Sbjct: 276 VDAVIDAYMNFITPPYVYEILVWCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVL--RT 333 Query: 307 DSLDTSI 313 DS T++ Sbjct: 334 DSSTTNL 340 >gi|15150803 opsin 4 isoform 1 [Homo sapiens] Length = 478 Score = 99.8 bits (247), Expect = 3e-21 Identities = 83/293 (28%), Positives = 137/293 (46%), Gaps = 16/293 (5%) Query: 11 ANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAI 70 A+ T T+ + +GL ++GN+ VI + SL+T FI++LA++D + P+ Sbjct: 69 AHYTLGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVFF 128 Query: 71 VVSLGITIHF--YSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIW 128 SL F C F +F +S+++L AIA+DRYL + + V + RR Sbjct: 129 TSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAA 188 Query: 129 LALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFI 188 L WL + L P FGW+ + + ++ F +R M+ F+ F+ Sbjct: 189 FVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFV--FFL 246 Query: 189 PLVVMCAIYLDIFYIIR--NKLSLNLSNSKETGAFYGR------EFKTAKSLFLVLFLFA 240 PL+++ Y+ IF IR + K G + E K AK + LV+ LF Sbjct: 247 PLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFV 306 Query: 241 LSWLPLSIINCIIYFNGEVPQLVLYMG---ILLSHANSMMNPIVYAYKIKKFK 290 LSW P S + ++ F G L YM +++ A+++ NPI+YA K++ Sbjct: 307 LSWAPYSAV-ALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 358 >gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sapiens] Length = 471 Score = 99.4 bits (246), Expect = 4e-21 Identities = 85/317 (26%), Positives = 140/317 (44%), Gaps = 58/317 (18%) Query: 24 LCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMP---LAIVVSLGITIHF 80 + I GN+LVI V L LQ T YF++SLA+AD+ +G LVMP L I+ + Sbjct: 86 ILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPS 145 Query: 81 YSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFL 140 C L ++F+ ASIM L AI++DRY+ ++ + + R + + +L + W +S Sbjct: 146 KLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVG 205 Query: 141 VGL-TPMFGW--NMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIY 197 + + P+FG + K+ E SC ++ D V FIPL +M Y Sbjct: 206 ISMPIPVFGLQDDSKVFKEG-------SC----LLADDNFVLIGSFVSFFIPLTIMVITY 254 Query: 198 LDIFYIIRNKLSLNLSN----------------------------SKETGAFYGR----- 224 ++ + +L +S+ +E G++ GR Sbjct: 255 FLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQS 314 Query: 225 ---EFKTAKSLFLVLFLFALSWLPLSIIN-----CIIYFNGEVPQLVLYMGILLSHANSM 276 E K K L +V FLF + W P I N C N +V +L + + + + +S Sbjct: 315 ISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSA 374 Query: 277 MNPIVYAYKIKKFKETY 293 +NP+VY K ++ + Sbjct: 375 VNPLVYTLFNKTYRSAF 391 >gi|71999131 opsin 3 [Homo sapiens] Length = 402 Score = 99.0 bits (245), Expect = 5e-21 Identities = 83/295 (28%), Positives = 132/295 (44%), Gaps = 40/295 (13%) Query: 22 IGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFY 81 IGL + N+LV+ + L+T T +V+++L+D+ V + G+T F Sbjct: 51 IGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLF----------GVTFTFV 100 Query: 82 SCL-------FMTCLL-----LIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWL 129 SCL + C+ +F SI +L +A +RY+RV + RV W Sbjct: 101 SCLRNGWVWDTVGCVWDGFSGSLFGIVSIATLTVLAYERYIRVV----HARVINFSWAWR 156 Query: 130 ALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDY----MVYFSFLTW 185 A+ WL S P+ GWN Y +V L C V D V F FL Sbjct: 157 AITYIWLYSLAWAGAPLLGWN-----RYILDVHGLGCT-VDWKSKDANDSSFVLFLFLGC 210 Query: 186 IFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLP 245 + +PL V+ Y I Y IR + + + E K AK FL++F F + W+P Sbjct: 211 LVVPLGVIAHCYGHILYSIRMLRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMP 270 Query: 246 LSIINCIIYFNGE---VPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLIL 297 +I C + NG V + + L + +N++ NP++Y + I+KF+ + L +L Sbjct: 271 YIVI-CFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLL 324 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.332 0.142 0.439 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 9,863,338 Number of Sequences: 37866 Number of extensions: 370344 Number of successful extensions: 2898 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 491 Number of HSP's successfully gapped in prelim test: 240 Number of HSP's that attempted gapping in prelim test: 1292 Number of HSP's gapped (non-prelim): 925 length of query: 318 length of database: 18,247,518 effective HSP length: 102 effective length of query: 216 effective length of database: 14,385,186 effective search space: 3107200176 effective search space used: 3107200176 T: 11 A: 40 X1: 15 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (22.0 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.