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Search of human proteins with 4501895
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4501895 activin A receptor, type I precursor [Homo sapiens]
(509 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 1051 0.0
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 1051 0.0
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 581 e-166
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 581 e-166
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 464 e-131
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 461 e-130
gi|4759226 transforming growth factor, beta receptor I isoform 1... 454 e-128
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 452 e-127
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 445 e-125
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 445 e-125
gi|195963412 transforming growth factor, beta receptor I isoform... 426 e-119
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 412 e-115
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 404 e-112
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 348 7e-96
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 293 2e-79
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 222 7e-58
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 217 2e-56
gi|67782324 transforming growth factor, beta receptor II isoform... 211 1e-54
gi|67782326 transforming growth factor, beta receptor II isoform... 211 1e-54
gi|15451916 bone morphogenetic protein receptor type II precurso... 206 5e-53
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 169 7e-42
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 94 4e-19
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 93 7e-19
gi|187475373 c-src tyrosine kinase [Homo sapiens] 92 1e-18
gi|4758078 c-src tyrosine kinase [Homo sapiens] 92 1e-18
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 89 9e-18
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 88 2e-17
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 88 2e-17
gi|75677325 kinase suppressor of ras [Homo sapiens] 86 6e-17
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 86 6e-17
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 1051 bits (2719), Expect = 0.0
Identities = 509/509 (100%), Positives = 509/509 (100%)
Query: 1 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN 60
MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
Sbjct: 1 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN 60
Query: 61 DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF 120
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
Sbjct: 61 DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF 120
Query: 121 HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL 180
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
Sbjct: 121 HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL 180
Query: 181 ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR 240
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
Sbjct: 181 ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR 240
Query: 241 DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL 300
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
Sbjct: 241 DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL 300
Query: 301 DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM 360
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
Sbjct: 301 DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM 360
Query: 361 HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS 420
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
Sbjct: 361 HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS 420
Query: 421 NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ 480
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
Sbjct: 421 NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ 480
Query: 481 NPSARLTALRIKKTLTKIDNSLDKLKTDC 509
NPSARLTALRIKKTLTKIDNSLDKLKTDC
Sbjct: 481 NPSARLTALRIKKTLTKIDNSLDKLKTDC 509
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 1051 bits (2719), Expect = 0.0
Identities = 509/509 (100%), Positives = 509/509 (100%)
Query: 1 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN 60
MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
Sbjct: 1 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN 60
Query: 61 DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF 120
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
Sbjct: 61 DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF 120
Query: 121 HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL 180
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
Sbjct: 121 HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL 180
Query: 181 ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR 240
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
Sbjct: 181 ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR 240
Query: 241 DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL 300
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
Sbjct: 241 DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL 300
Query: 301 DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM 360
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
Sbjct: 301 DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM 360
Query: 361 HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS 420
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
Sbjct: 361 HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS 420
Query: 421 NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ 480
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
Sbjct: 421 NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ 480
Query: 481 NPSARLTALRIKKTLTKIDNSLDKLKTDC 509
NPSARLTALRIKKTLTKIDNSLDKLKTDC
Sbjct: 481 NPSARLTALRIKKTLTKIDNSLDKLKTDC 509
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 581 bits (1497), Expect = e-166
Identities = 305/501 (60%), Positives = 360/501 (71%), Gaps = 15/501 (2%)
Query: 11 LIMIALPSPSMEDE-KPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQ-K 68
L+M+ + + D KP P L C CE C C G C L +G H + +
Sbjct: 10 LLMLLMALVTQGDPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVREEGRHPQEHR 67
Query: 69 GCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKG--KSFPGTQNFHLEVGL 126
GC ++ + C+ P+ CC CN N++ L PGT ++ L
Sbjct: 68 GCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDG---QLAL 121
Query: 127 IILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNVGDSTLADLLD 185
I+ V+ + L+A LGV RR QE+ E G ++ + GDS L DLLD
Sbjct: 122 ILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLD 179
Query: 186 HSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSW 245
CT+GSGSGLPFLVQRTVARQ+ L+ECVGKGRYGEVWRG W GE+VAVKIFSSRDE+SW
Sbjct: 180 SDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSW 239
Query: 246 FRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSC 305
FRETE+YNTV+LRH+NILGFIASDMTSR+SSTQLWLITHYHE GSLYD+LQ TL+
Sbjct: 240 FRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLA 299
Query: 306 LRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQST 365
LR+ +S A GLAHLH+EIFGTQGKPAIAHRD KS+N+LVK N QCCIADLGLAVMHSQ +
Sbjct: 300 LRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS 359
Query: 366 NQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVE 425
+ LD+GNNPRVGTKRYMAPEVLDE I+ DCF+SYK DIWAFGLVLWE+ARR + NGIVE
Sbjct: 360 DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVE 419
Query: 426 DYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485
DY+PPFYDVVPNDPSFEDM+KVVCVDQQ P IPNR +DP L+ LA++M+ECWY NPSAR
Sbjct: 420 DYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR 479
Query: 486 LTALRIKKTLTKIDNSLDKLK 506
LTALRIKKTL KI NS +K K
Sbjct: 480 LTALRIKKTLQKISNSPEKPK 500
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 581 bits (1497), Expect = e-166
Identities = 305/501 (60%), Positives = 360/501 (71%), Gaps = 15/501 (2%)
Query: 11 LIMIALPSPSMEDE-KPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQ-K 68
L+M+ + + D KP P L C CE C C G C L +G H + +
Sbjct: 10 LLMLLMALVTQGDPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVREEGRHPQEHR 67
Query: 69 GCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKG--KSFPGTQNFHLEVGL 126
GC ++ + C+ P+ CC CN N++ L PGT ++ L
Sbjct: 68 GCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDG---QLAL 121
Query: 127 IILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNVGDSTLADLLD 185
I+ V+ + L+A LGV RR QE+ E G ++ + GDS L DLLD
Sbjct: 122 ILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLD 179
Query: 186 HSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSW 245
CT+GSGSGLPFLVQRTVARQ+ L+ECVGKGRYGEVWRG W GE+VAVKIFSSRDE+SW
Sbjct: 180 SDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSW 239
Query: 246 FRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSC 305
FRETE+YNTV+LRH+NILGFIASDMTSR+SSTQLWLITHYHE GSLYD+LQ TL+
Sbjct: 240 FRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLA 299
Query: 306 LRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQST 365
LR+ +S A GLAHLH+EIFGTQGKPAIAHRD KS+N+LVK N QCCIADLGLAVMHSQ +
Sbjct: 300 LRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS 359
Query: 366 NQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVE 425
+ LD+GNNPRVGTKRYMAPEVLDE I+ DCF+SYK DIWAFGLVLWE+ARR + NGIVE
Sbjct: 360 DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVE 419
Query: 426 DYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485
DY+PPFYDVVPNDPSFEDM+KVVCVDQQ P IPNR +DP L+ LA++M+ECWY NPSAR
Sbjct: 420 DYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR 479
Query: 486 LTALRIKKTLTKIDNSLDKLK 506
LTALRIKKTL KI NS +K K
Sbjct: 480 LTALRIKKTLQKISNSPEKPK 500
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 464 bits (1195), Expect = e-131
Identities = 253/491 (51%), Positives = 326/491 (66%), Gaps = 19/491 (3%)
Query: 22 EDEKPKVNPKLYMCVCEGL----SCGNEDHCEGQQCFSSLSIND-GFHVYQKGCFQVYEQ 76
E P PK+ C C S N +G CF+ + +D G V GC + E
Sbjct: 19 ESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGY-CFTMIEEDDSGLPVVTSGCLGL-EG 76
Query: 77 GKMTCKTPPSPGQ--AVECC-QGDWCNRNITAQLPT-KGKSFPGTQNFHLEVGLIILSVV 132
C+ P P Q ++ECC + + CN+++ LP K + F H +++SV
Sbjct: 77 SDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRA---LLISVT 133
Query: 133 FAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGS 192
VC L +L + F+ + QE PR G + G+S L DL++ S +SGS
Sbjct: 134 --VCSLLLVLIILFCYFRYKRQET-RPR-YSIGLEQDETYIPPGES-LRDLIEQSQSSGS 188
Query: 193 GSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELY 252
GSGLP LVQRT+A+QI +++ +GKGRYGEVW G W+GE VAVK+F + +E SWFRETE+Y
Sbjct: 189 GSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIY 248
Query: 253 NTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSI 312
TV++RHENILGFIA+D+ S TQL+LIT YHE GSLYDYL+ TTLD S L++ S
Sbjct: 249 QTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSS 308
Query: 313 ASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGN 372
SGL HLH EIF TQGKPAIAHRDLKSKNILVKKNG CCIADLGLAV TN++D+
Sbjct: 309 VSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPP 368
Query: 373 NPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFY 432
N RVGTKRYM PEVLDE++ + F SY D+++FGL+LWEVARR VS GIVE+Y+ P++
Sbjct: 369 NTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYH 428
Query: 433 DVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIK 492
D+VP+DPS+EDMR++VC+ + RP+ PNRW SD L + KLM ECW NP++RLTALR+K
Sbjct: 429 DLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVK 488
Query: 493 KTLTKIDNSLD 503
KTL K+ S D
Sbjct: 489 KTLAKMSESQD 499
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 461 bits (1185), Expect = e-130
Identities = 243/460 (52%), Positives = 318/460 (69%), Gaps = 21/460 (4%)
Query: 53 CFSSLSIND-GFHVYQKGCFQVYEQGKMTCKTPPSPG--QAVECCQGDWCNRNITAQLPT 109
CF+ + +D G GC + YE CK P + +ECC+ + CN+ + LP
Sbjct: 82 CFAIIEEDDQGETTLASGCMK-YEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPP 140
Query: 110 K--GKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRR----NQERLNPRDVE 163
G F G+ + ++L + AVC++A ++ + +K + R RD+E
Sbjct: 141 VVIGPFFDGS------IRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLE 194
Query: 164 YGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVW 223
E I VG+S L DL+D S +SGSGSGLP LVQRT+A+QI ++ VGKGRYGEVW
Sbjct: 195 QD--EAFIP--VGES-LKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVW 249
Query: 224 RGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLIT 283
G W+GE VAVK+F + +E SWFRETE+Y TV++RHENILGFIA+D+ S TQL+LIT
Sbjct: 250 MGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLIT 309
Query: 284 HYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNIL 343
YHE GSLYD+L+ TLDT + L++ S A GL HLH EI+GTQGKPAIAHRDLKSKNIL
Sbjct: 310 DYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNIL 369
Query: 344 VKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVD 403
+KKNG CCIADLGLAV + TN++DV N RVGTKRYMAPEVLDE++ + F Y D
Sbjct: 370 IKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMAD 429
Query: 404 IWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFS 463
I++FGL++WE+ARR ++ GIVE+Y+ P+Y++VP+DPS+EDMR+VVCV + RP + NRW S
Sbjct: 430 IYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNS 489
Query: 464 DPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLD 503
D L ++ KLM ECW NP++RLTALRIKKTL K+ S D
Sbjct: 490 DECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQD 529
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 454 bits (1168), Expect = e-128
Identities = 235/406 (57%), Positives = 292/406 (71%), Gaps = 10/406 (2%)
Query: 93 CCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRR 152
CC D CN+ +LPT KS PG +E+ +I V VC+ + +L V + +
Sbjct: 100 CCNQDHCNK---IELPTTVKSSPGLGP--VELAAVIAGPVCFVCI-SLMLMVYICHNRTV 153
Query: 153 NQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLE 212
R+ P + + I+ +TL DL+ TSGSGSGLP LVQRT+AR I L E
Sbjct: 154 IHHRV-PNEEDPSLDRPFISEG---TTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQE 209
Query: 213 CVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTS 272
+GKGR+GEVWRG W+GE VAVKIFSSR+E+SWFRE E+Y TVMLRHENILGFIA+D
Sbjct: 210 SIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKD 269
Query: 273 RHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAI 332
+ TQLWL++ YHE GSL+DYL T+ +++ LS ASGLAHLH+EI GTQGKPAI
Sbjct: 270 NGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAI 329
Query: 333 AHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQ 392
AHRDLKSKNILVKKNG CCIADLGLAV H +T+ +D+ N RVGTKRYMAPEVLD++I
Sbjct: 330 AHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSIN 389
Query: 393 VDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQ 452
+ F+S+KR DI+A GLV WE+ARR GI EDY+ P+YD+VP+DPS E+MRKVVC +
Sbjct: 390 MKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQK 449
Query: 453 QRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
RPNIPNRW S L +AK+M+ECWY N +ARLTALRIKKTL+++
Sbjct: 450 LRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 495
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 452 bits (1163), Expect = e-127
Identities = 239/477 (50%), Positives = 312/477 (65%), Gaps = 15/477 (3%)
Query: 35 CVCEGLSCGNEDH-CEGQ-QCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVE 92
CVC L C + + C+ + C++S+ + +G K C + E + E
Sbjct: 28 CVC--LLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTE 85
Query: 93 CCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRR 152
CC D+CN NIT LPT + P L + + + + ++ + + R+ R
Sbjct: 86 CCFTDFCN-NITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYR 144
Query: 153 NQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLE 212
++R N + + N G TL DL+ SGSGSGLP LVQRT+AR I L E
Sbjct: 145 KKKRPNVEE----PLSECNLVNAG-KTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQE 199
Query: 213 CVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTS 272
VGKGR+GEVW G W GE+VAVKIFSSRDE+SWFRE E+Y TVMLRHENILGFIA+D
Sbjct: 200 IVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKD 259
Query: 273 RHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAI 332
+ TQLWL++ YHE GSLYDYL + +++ LSIASGLAHLH+EI GTQGKPAI
Sbjct: 260 NGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAI 319
Query: 333 AHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQ 392
AHRD+KSKNILVKK C IADLGLAV H N +D+ NP+VGTKRYMAPE+LD+T+
Sbjct: 320 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMN 379
Query: 393 VDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQ 452
V+ F+S+KR DI++ GLV WE+ARR GIVE+Y+ P+YD+VP+DPS E+MRKVVC +
Sbjct: 380 VNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQK 439
Query: 453 QRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 509
RP+IPN+W S L + ++M+ECWY N +ARLTALRIKKT++++ +K DC
Sbjct: 440 FRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL-----CVKEDC 491
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 445 bits (1144), Expect = e-125
Identities = 227/418 (54%), Positives = 289/418 (69%), Gaps = 11/418 (2%)
Query: 92 ECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKR 151
ECC D+CN NIT LPT + P L + + + + ++ + + R+
Sbjct: 35 ECCFTDFCN-NITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSY 93
Query: 152 RNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLL 211
R ++R N + + N G TL DL+ SGSGSGLP LVQRT+AR I L
Sbjct: 94 RKKKRPNVEE----PLSECNLVNAG-KTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQ 148
Query: 212 ECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMT 271
E VGKGR+GEVW G W GE+VAVKIFSSRDE+SWFRE E+Y TVMLRHENILGFIA+D
Sbjct: 149 EIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNK 208
Query: 272 SRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPA 331
+ TQLWL++ YHE GSLYDYL + +++ LSIASGLAHLH+EI GTQGKPA
Sbjct: 209 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA 268
Query: 332 IAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETI 391
IAHRD+KSKNILVKK C IADLGLAV H N +D+ NP+VGTKRYMAPE+LD+T+
Sbjct: 269 IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM 328
Query: 392 QVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVD 451
V+ F+S+KR DI++ GLV WE+ARR GIVE+Y+ P+YD+VP+DPS E+MRKVVC
Sbjct: 329 NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ 388
Query: 452 QQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 509
+ RP+IPN+W S L + ++M+ECWY N +ARLTALRIKKT++++ +K DC
Sbjct: 389 KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL-----CVKEDC 441
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 445 bits (1144), Expect = e-125
Identities = 244/472 (51%), Positives = 307/472 (65%), Gaps = 14/472 (2%)
Query: 34 MCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYE---QGKMTCKTPPSPGQA 90
+C C N C S+ DG + + C E GK +
Sbjct: 33 LCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRN 92
Query: 91 VECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGL--IILSVVFAVCLLACLLGVALRK 148
CC D+CNR I ++P+ P + V L II VF + L+ ++ + +
Sbjct: 93 THCCYTDYCNR-IDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINY 151
Query: 149 FKR--RNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVAR 206
+R N++RL D+E + E ++ D TL DL+ TSGSGSGLP VQRTVAR
Sbjct: 152 HQRVYHNRQRL---DMEDPSCEMCLSK---DKTLQDLVYDLSTSGSGSGLPLFVQRTVAR 205
Query: 207 QITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFI 266
I L E +GKGR+GEVWRG W+G +VAVKIFSSR+E+SWFRE E+Y TVMLRHENILGFI
Sbjct: 206 TIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFI 265
Query: 267 ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT 326
A+D + TQLWL++ YHE GSL+DYL T+ +++ LS ASGLAHLH+EI GT
Sbjct: 266 AADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGT 325
Query: 327 QGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEV 386
QGKP IAHRDLKSKNILVKKNG C IADLGLAV H T+ +D+ N RVGTKRYMAPEV
Sbjct: 326 QGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEV 385
Query: 387 LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK 446
LDETI + FDS+K DI+A GLV WE+ARR S G+ E+Y+ P+YD+VP+DPS E+MRK
Sbjct: 386 LDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRK 445
Query: 447 VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
VVC + RPNIPN W S L + K+M+ECWY N +ARLTALRIKKTL+++
Sbjct: 446 VVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQL 497
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 426 bits (1095), Expect = e-119
Identities = 203/305 (66%), Positives = 245/305 (80%)
Query: 194 SGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYN 253
+GLP LVQRT+AR I L E +GKGR+GEVWRG W+GE VAVKIFSSR+E+SWFRE E+Y
Sbjct: 114 TGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 173
Query: 254 TVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIA 313
TVMLRHENILGFIA+D + TQLWL++ YHE GSL+DYL T+ +++ LS A
Sbjct: 174 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA 233
Query: 314 SGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNN 373
SGLAHLH+EI GTQGKPAIAHRDLKSKNILVKKNG CCIADLGLAV H +T+ +D+ N
Sbjct: 234 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 293
Query: 374 PRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYD 433
RVGTKRYMAPEVLD++I + F+S+KR DI+A GLV WE+ARR GI EDY+ P+YD
Sbjct: 294 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 353
Query: 434 VVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 493
+VP+DPS E+MRKVVC + RPNIPNRW S L +AK+M+ECWY N +ARLTALRIKK
Sbjct: 354 LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 413
Query: 494 TLTKI 498
TL+++
Sbjct: 414 TLSQL 418
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 412 bits (1060), Expect = e-115
Identities = 198/316 (62%), Positives = 245/316 (77%), Gaps = 5/316 (1%)
Query: 194 SGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYN 253
+GLP LVQRT+AR I L E VGKGR+GEVW G W GE+VAVKIFSSRDE+SWFRE E+Y
Sbjct: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
Query: 254 TVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIA 313
TVMLRHENILGFIA+D + TQLWL++ YHE GSLYDYL + +++ LSIA
Sbjct: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
Query: 314 SGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNN 373
SGLAHLH+EI GTQGKPAIAHRD+KSKNILVKK C IADLGLAV H N +D+ N
Sbjct: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
Query: 374 PRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYD 433
P+VGTKRYMAPE+LD+T+ V+ F+S+KR DI++ GLV WE+ARR GIVE+Y+ P+YD
Sbjct: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
Query: 434 VVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 493
+VP+DPS E+MRKVVC + RP+IPN+W S L + ++M+ECWY N +ARLTALRIKK
Sbjct: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
Query: 494 TLTKIDNSLDKLKTDC 509
T++++ +K DC
Sbjct: 401 TISQL-----CVKEDC 411
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 404 bits (1037), Expect = e-112
Identities = 224/437 (51%), Positives = 280/437 (64%), Gaps = 14/437 (3%)
Query: 34 MCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYE---QGKMTCKTPPSPGQA 90
+C C N C S+ DG + + C E GK +
Sbjct: 33 LCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRN 92
Query: 91 VECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGL--IILSVVFAVCLLACLLGVALRK 148
CC D+CNR I ++P+ P + V L II VF + L+ ++ + +
Sbjct: 93 THCCYTDYCNR-IDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINY 151
Query: 149 FKR--RNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVAR 206
+R N++RL D+E + E ++ D TL DL+ TSGSGSGLP VQRTVAR
Sbjct: 152 HQRVYHNRQRL---DMEDPSCEMCLSK---DKTLQDLVYDLSTSGSGSGLPLFVQRTVAR 205
Query: 207 QITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFI 266
I L E +GKGR+GEVWRG W+G +VAVKIFSSR+E+SWFRE E+Y TVMLRHENILGFI
Sbjct: 206 TIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFI 265
Query: 267 ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT 326
A+D + TQLWL++ YHE GSL+DYL T+ +++ LS ASGLAHLH+EI GT
Sbjct: 266 AADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGT 325
Query: 327 QGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEV 386
QGKP IAHRDLKSKNILVKKNG C IADLGLAV H T+ +D+ N RVGTKRYMAPEV
Sbjct: 326 QGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEV 385
Query: 387 LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK 446
LDETI + FDS+K DI+A GLV WE+ARR S G+ E+Y+ P+YD+VP+DPS E+MRK
Sbjct: 386 LDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRK 445
Query: 447 VVCVDQQRPNIPNRWFS 463
VVC + RPNIPN W S
Sbjct: 446 VVCDQKLRPNIPNWWQS 462
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 348 bits (893), Expect = 7e-96
Identities = 199/396 (50%), Positives = 247/396 (62%), Gaps = 14/396 (3%)
Query: 34 MCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYE---QGKMTCKTPPSPGQA 90
+C C N C S+ DG + + C E GK +
Sbjct: 33 LCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRN 92
Query: 91 VECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGL--IILSVVFAVCLLACLLGVALRK 148
CC D+CNR I ++P+ P + V L II VF + L+ ++ + +
Sbjct: 93 THCCYTDYCNR-IDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINY 151
Query: 149 FKR--RNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVAR 206
+R N++RL D+E + E ++ D TL DL+ TSGSGSGLP VQRTVAR
Sbjct: 152 HQRVYHNRQRL---DMEDPSCEMCLSK---DKTLQDLVYDLSTSGSGSGLPLFVQRTVAR 205
Query: 207 QITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFI 266
I L E +GKGR+GEVWRG W+G +VAVKIFSSR+E+SWFRE E+Y TVMLRHENILGFI
Sbjct: 206 TIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFI 265
Query: 267 ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT 326
A+D + TQLWL++ YHE GSL+DYL T+ +++ LS ASGLAHLH+EI GT
Sbjct: 266 AADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGT 325
Query: 327 QGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEV 386
QGKP IAHRDLKSKNILVKKNG C IADLGLAV H T+ +D+ N RVGTKRYMAPEV
Sbjct: 326 QGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEV 385
Query: 387 LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNG 422
LDETI + FDS+K DI+A GLV WE+ARR S G
Sbjct: 386 LDETINMKHFDSFKCADIYALGLVYWEIARRCNSGG 421
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 293 bits (751), Expect = 2e-79
Identities = 140/239 (58%), Positives = 180/239 (75%), Gaps = 5/239 (2%)
Query: 271 TSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKP 330
T + TQLWL++ YHE GSLYDYL + +++ LSIASGLAHLH+EI GTQGKP
Sbjct: 101 TDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKP 160
Query: 331 AIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDET 390
AIAHRD+KSKNILVKK C IADLGLAV H N +D+ NP+VGTKRYMAPE+LD+T
Sbjct: 161 AIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDT 220
Query: 391 IQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCV 450
+ V+ F+S+KR DI++ GLV WE+ARR GIVE+Y+ P+YD+VP+DPS E+MRKVVC
Sbjct: 221 MNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCD 280
Query: 451 DQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 509
+ RP+IPN+W S L + ++M+ECWY N +ARLTALRIKKT++++ +K DC
Sbjct: 281 QKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL-----CVKEDC 334
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 222 bits (565), Expect = 7e-58
Identities = 155/483 (32%), Positives = 250/483 (51%), Gaps = 56/483 (11%)
Query: 46 DHCEGQQ-----CFSSLSINDG-FHVYQKGC----FQVYEQGKMTCKTPPSPGQAVECCQ 95
+ CEG+Q C++S + G + +KGC F Y++ + T +P CC+
Sbjct: 47 ERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVA-TEENPQVYFCCCE 105
Query: 96 GDWCNRNITAQLPTKGKSF-----PGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFK 150
G++CN T LP G P T L V L + + L+ L A ++
Sbjct: 106 GNFCNERFT-HLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLL---AFWMYR 161
Query: 151 RRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITL 210
R YG ++ I + G + L+ GL + + L
Sbjct: 162 HRKPP--------YGHVD--IHEDPGPPPPSPLV----------GL---------KPLQL 192
Query: 211 LECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDM 270
LE +GR+G VW+ + VAVKIF +D++SW E E+++T ++HEN+L FIA++
Sbjct: 193 LEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEK 252
Query: 271 TSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQG-- 328
+ +LWLIT +H+ GSL DYL+ + + +++ GL++LH ++ +G
Sbjct: 253 RGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEG 312
Query: 329 -KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVL 387
KP+IAHRD KSKN+L+K + +AD GLAV D + +VGT+RYMAPEVL
Sbjct: 313 HKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVL 370
Query: 388 DETIQVDCFDSYKRVDIWAFGLVLWE-VARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK 446
+ I D++ R+D++A GLVLWE V+R ++G V++Y PF + + PS E++++
Sbjct: 371 EGAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQE 429
Query: 447 VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLK 506
VV + RP I + W P L L ++ECW + ARL+A +++ ++ I S++
Sbjct: 430 VVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTT 489
Query: 507 TDC 509
+DC
Sbjct: 490 SDC 492
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 217 bits (553), Expect = 2e-56
Identities = 120/306 (39%), Positives = 185/306 (60%), Gaps = 6/306 (1%)
Query: 206 RQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGF 265
+ + LLE +GR+G VW+ E VAVKIF +D++SW E E+Y+ ++HENIL F
Sbjct: 190 KPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQF 249
Query: 266 IASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFG 325
I ++ LWLIT +HE GSL D+L+ + I ++A GLA+LH +I G
Sbjct: 250 IGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPG 309
Query: 326 TQG--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMA 383
+ KPAI+HRD+KSKN+L+K N CIAD GLA+ + D + +VGT+RYMA
Sbjct: 310 LKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMA 367
Query: 384 PEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARR-MVSNGIVEDYKPPFYDVVPNDPSFE 442
PEVL+ I D++ R+D++A GLVLWE+A R ++G V++Y PF + + PS E
Sbjct: 368 PEVLEGAINFQ-RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLE 426
Query: 443 DMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSL 502
DM++VV ++RP + + W + L + ++ECW + ARL+A + + +T++
Sbjct: 427 DMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLT 486
Query: 503 DKLKTD 508
+ + T+
Sbjct: 487 NIITTE 492
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 211 bits (538), Expect = 1e-54
Identities = 116/306 (37%), Positives = 179/306 (58%), Gaps = 10/306 (3%)
Query: 208 ITLLECVGKGRYGEVWRG------SWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHEN 261
I L VGKGR+ EV++ S Q E VAVKIF + SW E ++++ + L+HEN
Sbjct: 244 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 303
Query: 262 ILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHI 321
IL F+ ++ Q WLIT +H G+L +YL + ++ S+A G+AHLH
Sbjct: 304 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 363
Query: 322 EIFGTQGKPA--IAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTK 379
+ G+P I HRDLKS NILVK + CC+ D GL++ + + D+ N+ +VGT
Sbjct: 364 D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 422
Query: 380 RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDP 439
RYMAPEVL+ + ++ +S+K+ D+++ LVLWE+ R + G V+DY+PPF V P
Sbjct: 423 RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHP 482
Query: 440 SFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID 499
E M+ V D+ RP IP+ W + + + + + ECW +P ARLTA + + ++++
Sbjct: 483 CVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELE 542
Query: 500 NSLDKL 505
+ LD+L
Sbjct: 543 H-LDRL 547
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 211 bits (538), Expect = 1e-54
Identities = 116/306 (37%), Positives = 179/306 (58%), Gaps = 10/306 (3%)
Query: 208 ITLLECVGKGRYGEVWRG------SWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHEN 261
I L VGKGR+ EV++ S Q E VAVKIF + SW E ++++ + L+HEN
Sbjct: 269 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 328
Query: 262 ILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHI 321
IL F+ ++ Q WLIT +H G+L +YL + ++ S+A G+AHLH
Sbjct: 329 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 388
Query: 322 EIFGTQGKPA--IAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTK 379
+ G+P I HRDLKS NILVK + CC+ D GL++ + + D+ N+ +VGT
Sbjct: 389 D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 447
Query: 380 RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDP 439
RYMAPEVL+ + ++ +S+K+ D+++ LVLWE+ R + G V+DY+PPF V P
Sbjct: 448 RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHP 507
Query: 440 SFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID 499
E M+ V D+ RP IP+ W + + + + + ECW +P ARLTA + + ++++
Sbjct: 508 CVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELE 567
Query: 500 NSLDKL 505
+ LD+L
Sbjct: 568 H-LDRL 572
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 206 bits (523), Expect = 5e-53
Identities = 151/467 (32%), Positives = 232/467 (49%), Gaps = 61/467 (13%)
Query: 49 EGQQCFSSLSINDG-FHVYQKGCFQV--------YEQGKMTCKTPPSPGQAVE---CCQG 96
+G C+ + G ++ ++GC+ YE+ +T TPPS CC
Sbjct: 62 KGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTT-TPPSIQNGTYRFCCCST 120
Query: 97 DWCNRNITAQLP---TKGKSFPGTQNFHLEVGLIILSV-VFAVCLLACLLGVALRKFKRR 152
D CN N T P T S P + N + + + SV V AV ++A G + R+
Sbjct: 121 DLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRK 180
Query: 153 NQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLE 212
+GL + N+ ++ ++ P L + LLE
Sbjct: 181 ---------------QGLHSMNMMEAAASE--------------PSLD----LDNLKLLE 207
Query: 213 CVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASD-MT 271
+G+GRYG V++GS VAVK+FS + +++ E +Y ++ H+NI FI D
Sbjct: 208 LIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERV 267
Query: 272 SRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEI-FGTQGKP 330
+ + L+ Y+ GSL YL L T D VS R+ S+ GLA+LH E+ G KP
Sbjct: 268 TADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKP 327
Query: 331 AIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQS----TNQLDVGNNPRVGTKRYMAPEV 386
AI+HRDL S+N+LVK +G C I+D GL++ + + + D VGT RYMAPEV
Sbjct: 328 AISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEV 387
Query: 387 LDETIQV-DCFDSYKRVDIWAFGLVLWEVARR---MVSNGIVEDYKPPFYDVVPNDPSFE 442
L+ + + DC + K+VD++A GL+ WE+ R + V +Y+ F V N P+FE
Sbjct: 388 LEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFE 447
Query: 443 DMRKVVCVDQQRPNIPNRWFSDP-TLTSLAKLMKECWYQNPSARLTA 488
DM+ +V ++QRP P W + + SL + +++CW Q+ ARLTA
Sbjct: 448 DMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTA 494
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 169 bits (427), Expect = 7e-42
Identities = 144/478 (30%), Positives = 222/478 (46%), Gaps = 62/478 (12%)
Query: 53 CFSSLSIN-DGFHVYQKGCFQVYEQG--KMTC----KTPPSPGQAVECCQ--GDWCNRNI 103
CF ++ D V +GC E G + C + PSPG + C D+CN N
Sbjct: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY 120
Query: 104 TAQLPTKGKSFPGTQNFHLEVGLII---LSVVFAVCLLACLLGVALRKFKRRNQERLNPR 160
+ P PG+Q G I L ++ LL LLG + +R R+
Sbjct: 121 SHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGE 180
Query: 161 DVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYG 220
V + SG + V+ ++ + + +G +
Sbjct: 181 PVPEPRPD-------------------------SGRDWSVELQELPELCFSQVIREGGHA 215
Query: 221 EVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDM--TSRHSSTQ 278
VW G QG+ VA+K F R + E LY L+H++I+ FI + R S
Sbjct: 216 VVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGP 275
Query: 279 LWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT-QGKPAIAHRDL 337
L L+ H GSL YL T D S LR+ LS+A GLA LH E + Q KP IAHRDL
Sbjct: 276 L-LVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDL 334
Query: 338 KSKNILVKKNGQCCIADLGLA-VMHSQSTNQLDVGNNPR-------VGTKRYMAPEVLDE 389
S+N+L++++G C I DLGLA V+ + P+ GT+RYMAPE+LD+
Sbjct: 335 SSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDK 394
Query: 390 TIQV-DCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDV-----VPNDPSFED 443
T+ + D + +R DI++ L+LWE+ R + D PP + + + N P+ ++
Sbjct: 395 TLDLQDWGMALRRADIYSLALLLWEILSRCPD--LRPDSSPPPFQLAYEAELGNTPTSDE 452
Query: 444 MRKVVCVDQQRPNIPNRW---FSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
+ + +++RP IP+ W +DP L +L+++CW +P ARLTA +++ L +
Sbjct: 453 LWALAVQERRRPYIPSTWRCFATDP--DGLRELLEDCWDADPEARLTAECVQQRLAAL 508
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 93.6 bits (231), Expect = 4e-19
Identities = 85/304 (27%), Positives = 143/304 (47%), Gaps = 45/304 (14%)
Query: 194 SGLPFL--VQRTVARQITLLECVGKGRYGEVWRG--SWQGENVAVKIFSSRDEKSWFRET 249
SGLP + ++ T LE +GKG +GEV++G + + VA+KI + + +
Sbjct: 8 SGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDI 67
Query: 250 ELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIV 309
+ TV+ + ++ ++ S T+LW+I Y GS D L+ LD I+
Sbjct: 68 QQEITVLSQCDS--PYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATIL 125
Query: 310 LSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLD 369
I GL +LH E HRD+K+ N+L+ ++G+ +AD G+A Q T+
Sbjct: 126 REILKGLDYLHSE--------KKIHRDIKAANVLLSEHGEVKLADFGVA---GQLTD-TQ 173
Query: 370 VGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKP 429
+ N VGT +MAPEV+ ++ +DS + DIW+ G+ E+AR +P
Sbjct: 174 IKRNTFVGTPFWMAPEVIKQS----AYDS--KADIWSLGITAIELARG----------EP 217
Query: 430 PFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTAL 489
P ++ P M+ + + + P +S P L + ++ C + PS R TA
Sbjct: 218 PHSELHP-------MKVLFLIPKNNPPTLEGNYSKP----LKEFVEACLNKEPSFRPTAK 266
Query: 490 RIKK 493
+ K
Sbjct: 267 ELLK 270
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 92.8 bits (229), Expect = 7e-19
Identities = 81/287 (28%), Positives = 136/287 (47%), Gaps = 43/287 (14%)
Query: 209 TLLECVGKGRYGEVWRG--SWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFI 266
T LE +GKG +GEV++G + + VA+KI + + + + TV+ + ++ ++
Sbjct: 37 TKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS--PYV 94
Query: 267 ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT 326
S T+LW+I Y GS D L+ LD I+ I GL +LH E
Sbjct: 95 TKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE---- 150
Query: 327 QGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEV 386
HRD+K+ N+L+ ++G+ +AD G+A Q T+ + N VGT +MAPEV
Sbjct: 151 ----KKIHRDIKAANVLLSEHGEVKLADFGVA---GQLTD-TQIKRNTFVGTPFWMAPEV 202
Query: 387 LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK 446
+ ++ +DS + DIW+ G+ E+AR +PP ++ P M+
Sbjct: 203 IKQS----AYDS--KADIWSLGITAIELARG----------EPPHSELHP-------MKV 239
Query: 447 VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 493
+ + + P +S P L + ++ C + PS R TA + K
Sbjct: 240 LFLIPKNNPPTLEGNYSKP----LKEFVEACLNKEPSFRPTAKELLK 282
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 92.0 bits (227), Expect = 1e-18
Identities = 78/296 (26%), Positives = 136/296 (45%), Gaps = 48/296 (16%)
Query: 206 RQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGF 265
+++ LL+ +GKG +G+V G ++G VAVK + D + E LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKN-DATAQAFLAEASVMTQLRHSNLVQL 251
Query: 266 IASDMTSRHSSTQLWLITHYHEMGSLYDYLQ---LTTLDTVSCLRIVLSIASGLAHLHIE 322
+ + + L+++T Y GSL DYL+ + L L+ L + + +L
Sbjct: 252 LGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
Query: 323 IFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYM 382
F HRDL ++N+LV ++ ++D GL ++++ D G P ++
Sbjct: 309 NF--------VHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTGKLP----VKWT 353
Query: 383 APEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFE 442
APE L E + D+W+FG++LWE+ S G V + P DVVP E
Sbjct: 354 APEALREK------KFSTKSDVWSFGILLWEI----YSFGRVPYPRIPLKDVVPR---VE 400
Query: 443 DMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
K+ D P ++ ++MK CW+ + + R + L++++ L I
Sbjct: 401 KGYKMDAPDGCPP-------------AVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 92.0 bits (227), Expect = 1e-18
Identities = 78/296 (26%), Positives = 136/296 (45%), Gaps = 48/296 (16%)
Query: 206 RQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGF 265
+++ LL+ +GKG +G+V G ++G VAVK + D + E LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKN-DATAQAFLAEASVMTQLRHSNLVQL 251
Query: 266 IASDMTSRHSSTQLWLITHYHEMGSLYDYLQ---LTTLDTVSCLRIVLSIASGLAHLHIE 322
+ + + L+++T Y GSL DYL+ + L L+ L + + +L
Sbjct: 252 LGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
Query: 323 IFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYM 382
F HRDL ++N+LV ++ ++D GL ++++ D G P ++
Sbjct: 309 NF--------VHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTGKLP----VKWT 353
Query: 383 APEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFE 442
APE L E + D+W+FG++LWE+ S G V + P DVVP E
Sbjct: 354 APEALREK------KFSTKSDVWSFGILLWEI----YSFGRVPYPRIPLKDVVPR---VE 400
Query: 443 DMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
K+ D P ++ ++MK CW+ + + R + L++++ L I
Sbjct: 401 KGYKMDAPDGCPP-------------AVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 89.0 bits (219), Expect = 9e-18
Identities = 84/300 (28%), Positives = 135/300 (45%), Gaps = 53/300 (17%)
Query: 209 TLLECVGKGRYGEVWRG--SWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFI 266
T LE +GKG +GEV++G + + VA+KI + + + + TV+ + ++ ++
Sbjct: 25 TKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS--SYV 82
Query: 267 ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT 326
S ++LW+I Y GS D L+ D ++ I GL +LH E
Sbjct: 83 TKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSE---- 138
Query: 327 QGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEV 386
HRD+K+ N+L+ + G +AD G+A Q T+ + N VGT +MAPEV
Sbjct: 139 ----KKIHRDIKAANVLLSEQGDVKLADFGVA---GQLTD-TQIKRNTFVGTPFWMAPEV 190
Query: 387 LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK 446
IQ +DS + DIW+ G+ E+A+ +PP D+ P MR
Sbjct: 191 ----IQQSAYDS--KADIWSLGITAIELAKG----------EPPNSDMHP-------MRV 227
Query: 447 VVCVDQQRPNIPNRWFSDPTLT-----SLAKLMKECWYQNPSARLTALRIKKTLTKIDNS 501
+ + + P PTL S + + C ++PS R TA + K + NS
Sbjct: 228 LFLIPKNNP---------PTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNS 278
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 87.8 bits (216), Expect = 2e-17
Identities = 80/298 (26%), Positives = 133/298 (44%), Gaps = 53/298 (17%)
Query: 208 ITLLECVGKGRYGEVWRGSW--QGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGF 265
+ E G G +G V+R W Q + VAVK + +E E+ + +L H NI+ F
Sbjct: 16 LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQF 68
Query: 266 IASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVL---SIASGLAHLHIE 322
+ + ++T Y +GSLYDY+ + + I+ +A G+ +LH+E
Sbjct: 69 YGVILEPPNYG----IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME 124
Query: 323 IFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYM 382
+ HRDLKS+N+++ +G I D G + H+ +T+ VG P +M
Sbjct: 125 -----APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFP------WM 173
Query: 383 APEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFE 442
APEV+ + D+Y ++G+VLWE+ R V +E + + V N
Sbjct: 174 APEVIQSLPVSETCDTY------SYGVVLWEMLTREVPFKGLEGLQVAWLVVEKN----- 222
Query: 443 DMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDN 500
+R IP+ S P S A+L+ +CW + R + +I L + N
Sbjct: 223 ----------ERLTIPS---SCP--RSFAELLHQCWEADAKKRPSFKQIISILESMSN 265
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 87.8 bits (216), Expect = 2e-17
Identities = 80/298 (26%), Positives = 133/298 (44%), Gaps = 53/298 (17%)
Query: 208 ITLLECVGKGRYGEVWRGSW--QGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGF 265
+ E G G +G V+R W Q + VAVK + +E E+ + +L H NI+ F
Sbjct: 16 LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQF 68
Query: 266 IASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVL---SIASGLAHLHIE 322
+ + ++T Y +GSLYDY+ + + I+ +A G+ +LH+E
Sbjct: 69 YGVILEPPNYG----IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME 124
Query: 323 IFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYM 382
+ HRDLKS+N+++ +G I D G + H+ +T+ VG P +M
Sbjct: 125 -----APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFP------WM 173
Query: 383 APEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFE 442
APEV+ + D+Y ++G+VLWE+ R V +E + + V N
Sbjct: 174 APEVIQSLPVSETCDTY------SYGVVLWEMLTREVPFKGLEGLQVAWLVVEKN----- 222
Query: 443 DMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDN 500
+R IP+ S P S A+L+ +CW + R + +I L + N
Sbjct: 223 ----------ERLTIPS---SCP--RSFAELLHQCWEADAKKRPSFKQIISILESMSN 265
>gi|75677325 kinase suppressor of ras [Homo sapiens]
Length = 762
Score = 86.3 bits (212), Expect = 6e-17
Identities = 70/225 (31%), Positives = 113/225 (50%), Gaps = 33/225 (14%)
Query: 207 QITLLECVGKGRYGEVWRGSWQGENVAVKIFS----SRDEKSWFRETELYNTVMLRHENI 262
Q+ L E +G+GR+G V RG W GE VA+++ ++D F++ E+ N RHEN+
Sbjct: 475 QVELGEPIGQGRWGRVHRGRWHGE-VAIRLLEMDGHNQDHLKLFKK-EVMNYRQTRHENV 532
Query: 263 LGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQ--LTTLDTVSCLRIVLSIASGLAHLH 320
+ F+ + M H L +IT + + +L+ +++ T+LD +I I G+ +LH
Sbjct: 533 VLFMGACMNPPH----LAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLH 588
Query: 321 IEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGL-----AVMHSQSTNQLDVGNNPR 375
+ I H+DLKSKN+ NG+ I D GL V + NQL + ++
Sbjct: 589 AK--------GIVHKDLKSKNVFY-DNGKVVITDFGLFGISGVVREGRRENQLKLSHD-- 637
Query: 376 VGTKRYMAPEVLDETI---QVDCFDSYKRVDIWAFGLVLWEVARR 417
Y+APE++ E D K D++AFG V +E+ R
Sbjct: 638 --WLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQAR 680
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 86.3 bits (212), Expect = 6e-17
Identities = 80/287 (27%), Positives = 132/287 (45%), Gaps = 43/287 (14%)
Query: 209 TLLECVGKGRYGEVWRG--SWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFI 266
T L+ +GKG +GEV++G + E VA+KI + + + + TV+ + ++ +I
Sbjct: 21 TKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS--PYI 78
Query: 267 ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT 326
S ST+LW+I Y GS D L+ L+ I+ I GL +LH E
Sbjct: 79 TRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSE---- 134
Query: 327 QGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEV 386
HRD+K+ N+L+ + G +AD G+A Q T+ + N VGT +MAPEV
Sbjct: 135 ----RKIHRDIKAANVLLSEQGDVKLADFGVA---GQLTD-TQIKRNTFVGTPFWMAPEV 186
Query: 387 LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK 446
+ ++ +D + DIW+ G+ E+A+ +PP D+ P MR
Sbjct: 187 IKQS----AYDF--KADIWSLGITAIELAKG----------EPPNSDLHP-------MRV 223
Query: 447 VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 493
+ + + P S P + ++ C ++P R TA + K
Sbjct: 224 LFLIPKNSPPTLEGQHSKP----FKEFVEACLNKDPRFRPTAKELLK 266
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,173,286
Number of Sequences: 37866
Number of extensions: 916197
Number of successful extensions: 3568
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 294
Number of HSP's successfully gapped in prelim test: 436
Number of HSP's that attempted gapping in prelim test: 2341
Number of HSP's gapped (non-prelim): 828
length of query: 509
length of database: 18,247,518
effective HSP length: 107
effective length of query: 402
effective length of database: 14,195,856
effective search space: 5706734112
effective search space used: 5706734112
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.