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Search of human proteins with 41281683
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41281683 disabled homolog 2 interacting protein isoform 2
[Homo sapiens]
(1065 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 2122 0.0
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 2056 0.0
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 1171 0.0
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 1166 0.0
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 1019 0.0
gi|130502162 RAS protein activator like 3 [Homo sapiens] 449 e-126
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 180 7e-45
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 180 7e-45
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 134 5e-31
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 118 3e-26
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 118 3e-26
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 118 3e-26
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 118 3e-26
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 118 3e-26
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 117 6e-26
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 117 6e-26
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 115 2e-25
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 107 8e-23
gi|4759026 RAS protein activator like 1 [Homo sapiens] 106 1e-22
gi|116089337 IQ motif containing GTPase activating protein 2 [Ho... 54 8e-07
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 51 7e-06
gi|40353727 synaptopodin isoform A [Homo sapiens] 50 1e-05
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 49 3e-05
gi|7657387 CCR4-NOT transcription complex, subunit 3 [Homo sapiens] 49 3e-05
gi|150170670 piccolo isoform 2 [Homo sapiens] 48 4e-05
gi|150378539 piccolo isoform 1 [Homo sapiens] 48 4e-05
gi|146219843 Snf2-related CBP activator protein [Homo sapiens] 48 4e-05
gi|13129104 coiled-coil domain containing 86 [Homo sapiens] 48 4e-05
gi|157168329 formin 1 [Homo sapiens] 48 6e-05
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 48 6e-05
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 2122 bits (5497), Expect = 0.0
Identities = 1065/1065 (100%), Positives = 1065/1065 (100%)
Query: 1 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 60
MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC
Sbjct: 1 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 60
Query: 61 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 120
RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR
Sbjct: 61 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 120
Query: 121 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR 180
TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR
Sbjct: 121 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR 180
Query: 181 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE 240
QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE
Sbjct: 181 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE 240
Query: 241 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE 300
PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE
Sbjct: 241 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE 300
Query: 301 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN 360
YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN
Sbjct: 301 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN 360
Query: 361 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD 420
SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD
Sbjct: 361 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD 420
Query: 421 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT 480
DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT
Sbjct: 421 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT 480
Query: 481 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT 540
AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT
Sbjct: 481 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT 540
Query: 541 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA 600
NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA
Sbjct: 541 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA 600
Query: 601 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG 660
RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG
Sbjct: 601 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG 660
Query: 661 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR 720
WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR
Sbjct: 661 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR 720
Query: 721 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT 780
GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT
Sbjct: 721 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT 780
Query: 781 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS 840
VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS
Sbjct: 781 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS 840
Query: 841 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP 900
TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP
Sbjct: 841 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP 900
Query: 901 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG 960
HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG
Sbjct: 901 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG 960
Query: 961 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA 1020
EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA
Sbjct: 961 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA 1020
Query: 1021 NARLMSALTQLKERYSMQARNGISPTNPTKLQITENGEFRNSSNC 1065
NARLMSALTQLKERYSMQARNGISPTNPTKLQITENGEFRNSSNC
Sbjct: 1021 NARLMSALTQLKERYSMQARNGISPTNPTKLQITENGEFRNSSNC 1065
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 2056 bits (5327), Expect = 0.0
Identities = 1033/1033 (100%), Positives = 1033/1033 (100%)
Query: 1 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 60
MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC
Sbjct: 97 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 156
Query: 61 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 120
RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR
Sbjct: 157 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 216
Query: 121 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR 180
TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR
Sbjct: 217 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR 276
Query: 181 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE 240
QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE
Sbjct: 277 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE 336
Query: 241 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE 300
PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE
Sbjct: 337 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE 396
Query: 301 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN 360
YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN
Sbjct: 397 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN 456
Query: 361 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD 420
SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD
Sbjct: 457 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD 516
Query: 421 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT 480
DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT
Sbjct: 517 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT 576
Query: 481 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT 540
AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT
Sbjct: 577 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT 636
Query: 541 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA 600
NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA
Sbjct: 637 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA 696
Query: 601 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG 660
RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG
Sbjct: 697 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG 756
Query: 661 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR 720
WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR
Sbjct: 757 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR 816
Query: 721 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT 780
GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT
Sbjct: 817 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT 876
Query: 781 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS 840
VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS
Sbjct: 877 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS 936
Query: 841 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP 900
TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP
Sbjct: 937 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP 996
Query: 901 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG 960
HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG
Sbjct: 997 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG 1056
Query: 961 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA 1020
EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA
Sbjct: 1057 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA 1116
Query: 1021 NARLMSALTQLKE 1033
NARLMSALTQLKE
Sbjct: 1117 NARLMSALTQLKE 1129
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 1171 bits (3030), Expect = 0.0
Identities = 636/1093 (58%), Positives = 801/1093 (73%), Gaps = 72/1093 (6%)
Query: 1 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 60
+P+LKESRSHESLLSP S VE LDL E V +KP+HSSILGQD+CFEVT SGSKCFSC
Sbjct: 229 LPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSC 288
Query: 61 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 120
SA+ERDKWMENLRR V PNKDN RR E++L+LW+IEAKDL KKKY CELCLDD L+AR
Sbjct: 289 NSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFAR 348
Query: 121 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR 180
TT K K DN+FWGEHFEF +LPPL ++TVH+Y++ +KKKKK++N+Y+GLV++P ASV GR
Sbjct: 349 TTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGR 408
Query: 181 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE 240
QFVEKWYPV TP P GK GP IRIK+R+QTITILPME YKEFAE +T++Y LC+ LE
Sbjct: 409 QFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLE 468
Query: 241 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE 300
P++S + KEE+A ALVHILQSTG+ KDFLTDL+MSEVDRCG+++ LIFRENT+ATK+IEE
Sbjct: 469 PVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEE 528
Query: 301 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN 360
YLKLVGQ+YL DALGEFIKALYESDENCEVDPSKCS+++L +HQ NLKMCCELAFCKIIN
Sbjct: 529 YLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIIN 588
Query: 361 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD 420
SYCVFPRELKEVFASW+Q+C +RG+ DISERLISASLFLRFLCPAIMSPSLFNL+QEYPD
Sbjct: 589 SYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPD 648
Query: 421 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT 480
DRT+RTLTLIAKV QNLANFAKFG+KEEYM+FMN FLEHEW M+RFLLEISNP+T+SNT
Sbjct: 649 DRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNT 708
Query: 481 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALS--TPGSGQLP 538
GF+GYIDLGRELS LHSLLWE VSQL+++ V+KLGPLPR+L D+ +L+ TP QL
Sbjct: 709 PGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLR 768
Query: 539 GTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRS-SGVQP 597
+ S+P + S S+S+GLQK+ + S D +L SP+ +N D +F ++ VQ
Sbjct: 769 RFTEHNSSP-NVSGSLSSGLQKIFEDPTDS---DLHKLKSPSQDNTDSYFRGKTLLLVQQ 824
Query: 598 SPARSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQL 657
+ ++S +YSE +E + + N G+S+S++DLQD Q A +
Sbjct: 825 ASSQSMTYSEKDERESSLPN-GRSVSLMDLQDTHA-----------------AQVEHASV 866
Query: 658 VAGWPARAT--PVNLAGLATVRRAGQTPTTPGTS-------EGAPGRPQLLAPLSFQNPV 708
+ P R T +++ +A++++ +T +TP ++ A +P L PLSFQNPV
Sbjct: 867 MLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPV 926
Query: 709 YQMAAGLPLSPRGLGDSGSEGHSSLS--SHSNSEELAAAAKLGSFSTAAEELARR--PGE 764
Y + +P P+ DS E S+ S S SNSE+ + G +++ E+ +R E
Sbjct: 927 YHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLS---GPSNSSMEDFTKRSTQSE 983
Query: 765 LARRQMSLTEKGGQPTVPRQNSAGPQ--RRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYP 822
R+ ++ ++ +PRQNS G R++DQ R + PP+L +
Sbjct: 984 DFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQ-------GGLGARAKAPPSLPHSASLR 1036
Query: 823 RPSSGTLASAS--PDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQG----PSPV---SPN 873
S ++ SA+ + V +R RQQSSSS+ +SP K RA+ +Q SPV + +
Sbjct: 1037 STGSMSVVSAALVAEPVQNGSRSRQQSSSSR-ESPVPKVRAIQRQQTQQVQSPVDSATMS 1095
Query: 874 ALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEK---DLAVLQDKLRISTK 930
++RTAAW+L N Q ED + ++ DE AEK ++ L+++LR+S++
Sbjct: 1096 PVERTAAWVLN-NGQYEEDV--------EETEQNLDEAKHAEKYEQEITKLKERLRVSSR 1146
Query: 931 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK 990
+LEEYE QE+ QKL+LEY+ARLE+ EERLRRQQE+KD QMK IISRLM+VEEELK
Sbjct: 1147 RLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELK 1206
Query: 991 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGISPTNPTK 1050
KDHAEMQA +D+KQKIIDAQEKRI SLD+AN RLMSALTQ+KERYSMQ RNGISPTNPTK
Sbjct: 1207 KDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTK 1266
Query: 1051 LQITENGEFRNSS 1063
L ITENGEF+NSS
Sbjct: 1267 LSITENGEFKNSS 1279
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 1166 bits (3016), Expect = 0.0
Identities = 637/1100 (57%), Positives = 801/1100 (72%), Gaps = 79/1100 (7%)
Query: 1 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 60
+P+LKESRSHESLLSP S VE LDL E V +KP+HSSILGQD+CFEVT SGSKCFSC
Sbjct: 81 LPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSC 140
Query: 61 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 120
SA+ERDKWMENLRR V PNKDN RR E++L+LW+IEAKDL KKKY CELCLDD L+AR
Sbjct: 141 NSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFAR 200
Query: 121 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR 180
TT K K DN+FWGEHFEF +LPPL ++TVH+Y++ +KKKKK++N+Y+GLV++P ASV GR
Sbjct: 201 TTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGR 260
Query: 181 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE 240
QFVEKWYPV TP P GK GP IRIK+R+QTITILPME YKEFAE +T++Y LC+ LE
Sbjct: 261 QFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLE 320
Query: 241 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE 300
P++S + KEE+A ALVHILQSTG+ KDFLTDL+MSEVDRCG+++ LIFRENT+ATK+IEE
Sbjct: 321 PVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEE 380
Query: 301 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN 360
YLKLVGQ+YL DALGEFIKALYESDENCEVDPSKCS+++L +HQ NLKMCCELAFCKIIN
Sbjct: 381 YLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIIN 440
Query: 361 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD 420
SYCVFPRELKEVFASW+Q+C +RG+ DISERLISASLFLRFLCPAIMSPSLFNL+QEYPD
Sbjct: 441 SYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPD 500
Query: 421 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT 480
DRT+RTLTLIAKV QNLANFAKFG+KEEYM+FMN FLEHEW M+RFLLEISNP+T+SNT
Sbjct: 501 DRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNT 560
Query: 481 AGFEGYIDLGRELSSLHSLLWEAVSQLE-------QSIVSKLGPLPRILRDVHTALS--T 531
GF+GYIDLGRELS LHSLLWE VSQL+ Q+ V+KLGPLPR+L D+ +L+ T
Sbjct: 561 PGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPT 620
Query: 532 PGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTR 591
P QL + S+P + S S+S+GLQK+ + S D +L SP+ +N D +F +
Sbjct: 621 PIQQQLRRFTEHNSSP-NVSGSLSSGLQKIFEDPTDS---DLHKLKSPSQDNTDSYFRGK 676
Query: 592 S-SGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDG 650
+ VQ + ++S +YSE +E + + N G+S+S++DLQD
Sbjct: 677 TLLLVQQASSQSMTYSEKDERESSLPN-GRSVSLMDLQDTHA-----------------A 718
Query: 651 QAAAAQLVAGWPARAT--PVNLAGLATVRRAGQTPTTPGTS-------EGAPGRPQLLAP 701
Q A ++ P R T +++ +A++++ +T +TP ++ A +P L P
Sbjct: 719 QVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQP 778
Query: 702 LSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLS--SHSNSEELAAAAKLGSFSTAAEELA 759
LSFQNPVY + +P P+ DS E S+ S S SNSE+ + G +++ E+
Sbjct: 779 LSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLS---GPSNSSMEDFT 835
Query: 760 RR--PGELARRQMSLTEKGGQPTVPRQNSAGPQ--RRIDQPPPPPPPPPPAPRGRTPPNL 815
+R E R+ ++ ++ +PRQNS G R++DQ R + PP+L
Sbjct: 836 KRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQ-------GGLGARAKAPPSL 888
Query: 816 LSTLQYPRPSSGTLASAS--PDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQG----PSP 869
+ S ++ SA+ + V +R RQQSSSS+ +SP K RA+ +Q SP
Sbjct: 889 PHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSR-ESPVPKVRAIQRQQTQQVQSP 947
Query: 870 V---SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEK---DLAVLQD 923
V + + ++RTAAW+L N Q ED + ++ DE AEK ++ L++
Sbjct: 948 VDSATMSPVERTAAWVLN-NGQYEEDV--------EETEQNLDEAKHAEKYEQEITKLKE 998
Query: 924 KLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLM 983
+LR+S+++LEEYE QE+ QKL+LEY+ARLE+ EERLRRQQE+KD QMK IISRLM
Sbjct: 999 RLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLM 1058
Query: 984 SVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGI 1043
+VEEELKKDHAEMQA +D+KQKIIDAQEKRI SLD+AN RLMSALTQ+KERYSMQ RNGI
Sbjct: 1059 AVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGI 1118
Query: 1044 SPTNPTKLQITENGEFRNSS 1063
SPTNPTKL ITENGEF+NSS
Sbjct: 1119 SPTNPTKLSITENGEFKNSS 1138
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapiens]
Length = 1343
Score = 1019 bits (2635), Expect = 0.0
Identities = 579/1187 (48%), Positives = 759/1187 (63%), Gaps = 141/1187 (11%)
Query: 1 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 60
M KES SHESLLSPSSA EAL+L+++E+ +IKPVHSSILGQ++CFEVTTSSG+KCF+C
Sbjct: 174 MQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFAC 233
Query: 61 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 120
RSAAERDKW+ENL+RAV PNKDNSRRV+++LKLW+IEA++LP KK+Y CELCLDD+LYAR
Sbjct: 234 RSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYAR 293
Query: 121 TTGKLKT---DNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASV 177
TT K ++ D VFWGEHFEF+NLP +R + +HLYR++DKK+KK++ Y+GLV++P A++
Sbjct: 294 TTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATL 353
Query: 178 AGRQFVEKWYPVVTPNPKGG--------------------KGPGPMIRIKARYQTITILP 217
AGR F E+WYPV P GG KG P +R+KARYQT++ILP
Sbjct: 354 AGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILP 413
Query: 218 MEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEV 277
ME+YKEFAE++TNHY LCA LEP L+ K KEE+ASALVHILQSTGK KDFL+D+ MSEV
Sbjct: 414 MELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEV 473
Query: 278 DRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSA 337
DR + EHLIFRENTLATKAIEEY++L+GQKYL+DA+GEFI+ALYES+ENCEVDP KC+A
Sbjct: 474 DRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTA 533
Query: 338 ADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASL 397
+ L EHQ NL+MCCELA CK++NS+CVFPRELKEVFASWR C+ RGR DI++RLISASL
Sbjct: 534 SSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASL 593
Query: 398 FLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFL 457
FLRFLCPAIMSPSLF L+QEYPD++T+RTLTLIAKV QNLANF+KF SKE+++ FMN+FL
Sbjct: 594 FLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFL 653
Query: 458 EHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGP 517
E EW +MQ+FL EISN +TL+N++ FEGYIDLGRELS+LH+LLWE + QL + + KLGP
Sbjct: 654 ELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGP 713
Query: 518 LPRILRDVHTALSTPGSGQLPGTNDLASTPG----SGSSSISAGLQ----------KMVI 563
LPR+L D+ TAL P + P P G S+ G + +
Sbjct: 714 LPRLLNDISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFM 773
Query: 564 ENDLSGLIDFTRLPSPTPE---------NKDLFFVTRSSGVQPSPARSSSYSEANEPDLQ 614
L+ +D RLPSPT E KDLF+V+R + SPA +S S+ EP+ +
Sbjct: 774 ARGLNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQK 833
Query: 615 MANGGKSLSMVDLQ----DARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNL 670
M + KS+SM+DLQ R + A L QA+ + PA A ++
Sbjct: 834 MLSVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQ 893
Query: 671 AGLATVRRAGQTPTTPG-TSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEG 729
+++ AG + G T++G P + QL PLSFQNP++ MAA P P G G G G
Sbjct: 894 GSGSSITAAGMRLSQMGVTTDGVPAQ-QLRIPLSFQNPLFHMAADGPGPPGGHGGGG--G 950
Query: 730 HSSLSSH-------------------------SNSEELAA------AAKLGSFSTAAEEL 758
H SSH S SE+L++ AA + + ++E
Sbjct: 951 HGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEF 1010
Query: 759 ARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPP--------------PPP 804
+ RRQ+SL + P Q + GPQR P P P PP
Sbjct: 1011 GPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQR----PAPSGPGGGSGGGSGGGGGGQPP 1066
Query: 805 PAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGD----------- 853
P RG++ +S Q PRPSSG L + GP+ R RQQS S +G
Sbjct: 1067 PLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPA-RPRQQSLSKEGSIGGSGGSGGGG 1125
Query: 854 SPELKPRAV--HKQGPSPVSPN--ALDRTAAWLLTMNAQLLEDEGLGPDPPH---RDRLR 906
LKP H Q PS ++P A +RT AW+ M + E + ++ +
Sbjct: 1126 GGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSK 1185
Query: 907 SKDE-----LSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGE 961
S DE + + E+++ L+++L +S +KLEEYE QEE T K++++YQARLE+ E
Sbjct: 1186 SMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSE 1245
Query: 962 ERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEM-QAAVDSKQKIIDAQEKRIASLDAA 1020
+RLR+QQ +KD Q+K II RLM VEEEL++DH M + + K++++DAQE+++ L
Sbjct: 1246 KRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPT 1305
Query: 1021 NARLMSALTQLKERYSMQARNGI---SPTNPTKLQITENGEFRNSSN 1064
N R+ A NG+ +P P +LQITENGEFRN+++
Sbjct: 1306 NPRVTLA----------PPWNGLAPPAPPPPPRLQITENGEFRNTAD 1342
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 449 bits (1156), Expect = e-126
Identities = 270/610 (44%), Positives = 360/610 (59%), Gaps = 54/610 (8%)
Query: 9 SHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDK 68
S ESL + S LDL E +V I P+H S+LG+ +CF+VT + GS+CFSCRSAAERD+
Sbjct: 228 SRESLATLSE----LDLGAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDR 283
Query: 69 WMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKK----YLCELCLDDVLYARTTGK 124
W+E+LRR P +DN R E L +WV EAK LP EL LD L ART +
Sbjct: 284 WIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPR 343
Query: 125 LKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSL-------PAASV 177
+FW E F F LPP R +++ L + ++ LG V+L P A
Sbjct: 344 AGPGQLFWAERFHFEALPPARRLSLRL------RGLGPGSAVLGRVALALEELDAPRAPA 397
Query: 178 AGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCA 237
AG +E+W+P++ G G +R + R + + +LP E YKE AE +T HY LC
Sbjct: 398 AG---LERWFPLL------GAPAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCG 448
Query: 238 ALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKA 297
ALEP L A+ KEE+A+A+V +L++TG+ + +TDL +E+ RCG E L+FRENTLATKA
Sbjct: 449 ALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKA 508
Query: 298 IEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCK 357
I+EY+KLV Q YLQ+ LG+ ++ L S E+CEVDPSKC A++LPEHQ L+ CE F
Sbjct: 509 IDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASELPEHQARLRNSCEEVFET 568
Query: 358 IINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQE 417
II+SY FP EL VF+SWR+ C RG + RL+ ASLFLR LCPAI++PSLF L +
Sbjct: 569 IIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVCASLFLRLLCPAILAPSLFGLAPD 628
Query: 418 YPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETL 477
+P ARTLTLIAKV QNLAN A FG KE YM FMN FLE MQ FL +++ +
Sbjct: 629 HPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVD 688
Query: 478 SNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVH----TALSTPG 533
+ +G++G DL +L+ LH+ L ++L+Q+ L PLP ILR + +S P
Sbjct: 689 AAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDTLEPLPTILRAIEEGQPVLVSVPM 748
Query: 534 SGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTP---ENKDLFFVT 590
LP P SS+SAG + G + LP TP +++ L V
Sbjct: 749 RLPLP--------PAQVHSSLSAG--------EKPGFLAPRDLPKHTPLISKSQSLRSVR 792
Query: 591 RS-SGVQPSP 599
RS S +P P
Sbjct: 793 RSESWARPRP 802
Score = 34.3 bits (77), Expect = 0.64
Identities = 62/290 (21%), Positives = 107/290 (36%), Gaps = 53/290 (18%)
Query: 761 RPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQ 820
+PG LA R + P + + S RR + P P R P ++
Sbjct: 766 KPGFLAPRDLPKHT----PLISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVP 821
Query: 821 YPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAA 880
RP+ SA P W P + S S G +P +P P P+
Sbjct: 822 VRRPARRR-QSAGP-WPRP------KGSLSMGPAPRARPWT-RDSASLPRKPSV-----P 867
Query: 881 WLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFK 940
W M+ ++ LG P ++L++ + ++A L+++ ++ ++ +E T +
Sbjct: 868 WQRQMDQPQDRNQALGTHRP-------VNKLAELQCEVAALREEQKVLSRLVESLSTQIR 920
Query: 941 CQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAV 1000
L E +E+LR Q +D D SRL + E +H
Sbjct: 921 A---------------LTEQQEQLRGQLQDLD-------SRLRAGSSEFDSEHNLTSNEG 958
Query: 1001 DSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGISPTNPTK 1050
S + + E R+ ++ A+L A+ L + S + R S P K
Sbjct: 959 HSLKNL----EHRLNEMERTQAQLRDAVQSL--QLSPRTRGSWSQPQPLK 1002
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 180 bits (456), Expect = 7e-45
Identities = 146/527 (27%), Positives = 249/527 (47%), Gaps = 29/527 (5%)
Query: 36 VHSSILGQDYCFEVTTSSGSK-----CFSCRSAAERDKWMENLR-----RAVHPNKDNSR 85
VH S+ G+ CF++ S+ F+ + + + WM+ L+ R P N R
Sbjct: 530 VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 589
Query: 86 -RVEHILKLWVIEAKDLPAKK--KYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLP 142
R L L + EA LP K C + L+ V A+T + + N W E F F +LP
Sbjct: 590 LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLP 648
Query: 143 PLRTVTVHLYRET-DKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPG 201
P ++ + T K KK ++ + + + + ++W+ + + P G PG
Sbjct: 649 P----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 704
Query: 202 PMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQS 261
+ R++ARY I+P E Y EF E I L + AL + + + +AS L+ I
Sbjct: 705 SL-RVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILLRIFLH 762
Query: 262 TGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKAL 321
K++ L + D +FR TLA+ +E+Y+K +++ AL + I +
Sbjct: 763 E-KLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKI 821
Query: 322 YESDENCEVDPSKCSA-ADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQEC 380
ES ++CE+ PSK D+ + +L KI + + P L+ ++ ++
Sbjct: 822 MESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSV 881
Query: 381 SSRGRPDIS--ERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLA 438
+ + + R++S +FLR +CPAI++P +FN++ + P ARTL L+AK QNLA
Sbjct: 882 QHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLA 941
Query: 439 NFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHS 498
N +FG+KE YM +N F++ M FL E+ N L +T DL R+L++LH
Sbjct: 942 NLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTE-HSRTDLSRDLAALHE 1000
Query: 499 LLWEAVSQLEQSIVSKLGPLPRILRDV--HTALSTPGSGQLPGTNDL 543
+ +L +++ ++ G +L+ + T L Q TND+
Sbjct: 1001 ICVAHSDEL-RTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDV 1046
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 180 bits (456), Expect = 7e-45
Identities = 146/527 (27%), Positives = 249/527 (47%), Gaps = 29/527 (5%)
Query: 36 VHSSILGQDYCFEVTTSSGSK-----CFSCRSAAERDKWMENLR-----RAVHPNKDNSR 85
VH S+ G+ CF++ S+ F+ + + + WM+ L+ R P N R
Sbjct: 353 VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 412
Query: 86 -RVEHILKLWVIEAKDLPAKK--KYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLP 142
R L L + EA LP K C + L+ V A+T + + N W E F F +LP
Sbjct: 413 LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLP 471
Query: 143 PLRTVTVHLYRET-DKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPG 201
P ++ + T K KK ++ + + + + ++W+ + + P G PG
Sbjct: 472 P----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 527
Query: 202 PMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQS 261
+ R++ARY I+P E Y EF E I L + AL + + + +AS L+ I
Sbjct: 528 SL-RVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILLRIFLH 585
Query: 262 TGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKAL 321
K++ L + D +FR TLA+ +E+Y+K +++ AL + I +
Sbjct: 586 E-KLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKI 644
Query: 322 YESDENCEVDPSKCSA-ADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQEC 380
ES ++CE+ PSK D+ + +L KI + + P L+ ++ ++
Sbjct: 645 MESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSV 704
Query: 381 SSRGRPDIS--ERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLA 438
+ + + R++S +FLR +CPAI++P +FN++ + P ARTL L+AK QNLA
Sbjct: 705 QHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLA 764
Query: 439 NFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHS 498
N +FG+KE YM +N F++ M FL E+ N L +T DL R+L++LH
Sbjct: 765 NLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTE-HSRTDLSRDLAALHE 823
Query: 499 LLWEAVSQLEQSIVSKLGPLPRILRDV--HTALSTPGSGQLPGTNDL 543
+ +L +++ ++ G +L+ + T L Q TND+
Sbjct: 824 ICVAHSDEL-RTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDV 869
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 134 bits (337), Expect = 5e-31
Identities = 111/391 (28%), Positives = 183/391 (46%), Gaps = 40/391 (10%)
Query: 120 RTTGKLKTDNVFWGE-----------HFEFHNLPPLRT-VTVHLYRETDKKKKKERNSYL 167
R T + D VF+ E HF+F + + V L+ ++ K E +L
Sbjct: 187 RKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE---FL 243
Query: 168 GLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGP----MIRIKARYQTITILPMEMYKE 223
G + +P + E WY + P G K P +R+ Y + + Y
Sbjct: 244 GELRIPLKVLRQSSSYEAWY-FLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSP 302
Query: 224 FAEHITNHYLGLCAALEPILSA---------KTKEEMASALVHILQSTGKVKDFLTDLMM 274
+ + A +EP+ ++ + K+E A LV + G+V F++ +
Sbjct: 303 LRDLLLKS-----ADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIAS 357
Query: 275 SEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSK 334
+EV R D + IFR N+LA+K I+E +KL G YL L I+ + +S + CE+DP K
Sbjct: 358 AEVKRTQD-PNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVK 416
Query: 335 CSAAD-LPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGR--PDISER 391
+ L + NL+ + F I S P + ++F S R+ + R + PD+
Sbjct: 417 LKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYT 476
Query: 392 LISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMS 451
+S+ +FLRF PAI+SP+LF L + D +T+RTLTLI+K Q L + +K S S
Sbjct: 477 AVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKES 536
Query: 452 FMNQFLEHEWTNMQRFLLEISNPETLSNTAG 482
+M F +E+ N Q++ + N L +++G
Sbjct: 537 YMATF--YEFFNEQKYADAVKNFLDLISSSG 565
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 118 bits (296), Expect = 3e-26
Identities = 98/338 (28%), Positives = 164/338 (48%), Gaps = 22/338 (6%)
Query: 166 YLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGP----MIRIKARYQTITILPMEMY 221
+LG + +P + + WY ++ P G K +R+ Y +LP E Y
Sbjct: 268 FLGEIKVPVNVLRTDSSHQAWY-LLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYY 326
Query: 222 KEFAEHITNH--YLGLCAALEPILS--AKTKEEMASALVHILQSTGKVKDFLTDLMMSEV 277
+ + A+ ILS + K + LV +L K+ F T ++E+
Sbjct: 327 GPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFAT--AVAEL 384
Query: 278 D-RCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCS 336
D + + + IFR N+LAT+ ++E +K+VG YL+ L + + +S ++CE+DP K
Sbjct: 385 DLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK 444
Query: 337 AADLPEH-QGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSR--GRPDISERLI 393
D E+ + NL+ + F I+ S P + ++F S RQ + R P + +
Sbjct: 445 EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAV 504
Query: 394 SASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANF-----AKFGSKEE 448
S+ +FLRF A++SP F+L +PD +T RTLTLI+K Q L ++ +K KE
Sbjct: 505 SSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKET 564
Query: 449 YM-SFMNQFLEHEW-TNMQRFLLEISNPETLSNTAGFE 484
+M F F E + +++FL EIS+ ET ++ E
Sbjct: 565 FMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSE 602
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 118 bits (295), Expect = 3e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 91 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 143
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 63 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119
Query: 144 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 200
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 120 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
Query: 201 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 252
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 177 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 235
Query: 253 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 312
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 294
Query: 313 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 357
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
Query: 358 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 413
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 355 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 414
Query: 414 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 471
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 415 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 474
Query: 472 SNPETLSNTAGFEGYIDLGRELS 494
+ E + +DL R LS
Sbjct: 475 VDIEE-------KDELDLQRTLS 490
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 118 bits (295), Expect = 3e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 91 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 143
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
Query: 144 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 200
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
Query: 201 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 252
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
Query: 253 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 312
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 366
Query: 313 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 357
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 358 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 413
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
Query: 414 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 471
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 546
Query: 472 SNPETLSNTAGFEGYIDLGRELS 494
+ E + +DL R LS
Sbjct: 547 VDIEE-------KDELDLQRTLS 562
Score = 34.7 bits (78), Expect = 0.49
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 91 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 145
L + ++E K+LPAK C + +D+ RT KT FWGE ++ H P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 146 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 178
V ++ E R+ +G V L ++A
Sbjct: 67 AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 118 bits (295), Expect = 3e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 91 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 143
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 63 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119
Query: 144 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 200
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 120 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
Query: 201 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 252
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 177 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 235
Query: 253 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 312
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 294
Query: 313 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 357
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
Query: 358 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 413
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 355 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 414
Query: 414 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 471
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 415 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 474
Query: 472 SNPETLSNTAGFEGYIDLGRELS 494
+ E + +DL R LS
Sbjct: 475 VDIEE-------KDELDLQRTLS 490
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 118 bits (295), Expect = 3e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 91 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 143
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
Query: 144 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 200
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
Query: 201 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 252
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
Query: 253 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 312
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 366
Query: 313 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 357
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 358 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 413
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
Query: 414 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 471
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 546
Query: 472 SNPETLSNTAGFEGYIDLGRELS 494
+ E + +DL R LS
Sbjct: 547 VDIEE-------KDELDLQRTLS 562
Score = 34.7 bits (78), Expect = 0.49
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 91 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 145
L + ++E K+LPAK C + +D+ RT KT FWGE ++ H P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 146 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 178
V ++ E R+ +G V L ++A
Sbjct: 67 AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 117 bits (293), Expect = 6e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 91 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 143
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
Query: 144 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 200
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
Query: 201 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 252
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
Query: 253 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 312
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSMESFLKVAGMQYLHG 366
Query: 313 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 357
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 358 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 413
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
Query: 414 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 471
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKL 546
Query: 472 SNPETLSNTAGFEGYIDLGRELS 494
+ E + +DL R LS
Sbjct: 547 VDIEE-------KDELDLQRTLS 562
Score = 34.7 bits (78), Expect = 0.49
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 91 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 145
L + ++E K+LPAK C + +D+ RT KT FWGE ++ H P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 146 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 178
V ++ E R+ +G V L ++A
Sbjct: 67 AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 117 bits (293), Expect = 6e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 91 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 143
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
Query: 144 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 200
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
Query: 201 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 252
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
Query: 253 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 312
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSMESFLKVAGMQYLHG 366
Query: 313 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 357
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 358 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 413
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
Query: 414 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 471
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKL 546
Query: 472 SNPETLSNTAGFEGYIDLGRELS 494
+ E + +DL R LS
Sbjct: 547 VDIEE-------KDELDLQRTLS 562
Score = 34.7 bits (78), Expect = 0.49
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 91 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 145
L + ++E K+LPAK C + +D+ RT KT FWGE ++ H P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 146 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 178
V ++ E R+ +G V L ++A
Sbjct: 67 AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 115 bits (288), Expect = 2e-25
Identities = 89/287 (31%), Positives = 146/287 (50%), Gaps = 10/287 (3%)
Query: 233 LGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENT 292
L + AL ++ +E+A LV + S + L ++ EV+ D+ +FR N+
Sbjct: 1221 LPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVE-LADSMQTLFRGNS 1279
Query: 293 LATKAIEEYLKLVGQKYLQDALGEFIKALYESDE----NCEVDPSKCSAAD-LPEHQGNL 347
LA+K + K+ G YLQ L ++ + S + + EVDP++ ++ L E+Q NL
Sbjct: 1280 LASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNL 1339
Query: 348 KMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIM 407
E F II+S FP +L+ V Q S R P S + +++FLRF+ PAI+
Sbjct: 1340 LQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRF-PQNSIGAVGSAMFLRFINPAIV 1398
Query: 408 SPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRF 467
SP +L + P R R L L++K+ Q++AN F +KEE+M N F++ + +RF
Sbjct: 1399 SPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEHMRPFNDFVKSNFDAARRF 1457
Query: 468 LLEISNPETLSNTAGFE-GYIDLGRELSSLHSLLWEAVSQLEQSIVS 513
L+I++ S+ +I G L +LH LLW ++ Q + S
Sbjct: 1458 FLDIASDCPTSDAVNHSLSFISDGNVL-ALHRLLWNNQEKIGQYLSS 1503
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 107 bits (266), Expect = 8e-23
Identities = 88/307 (28%), Positives = 150/307 (48%), Gaps = 29/307 (9%)
Query: 233 LGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENT 292
L + AL ++ +E+A LV + S + L ++ EV+ D+ +FR N+
Sbjct: 1221 LPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVE-LADSMQTLFRGNS 1279
Query: 293 LATKAIEEYLKLVGQKYLQDALGEFIKALYESDE----NCEVDPSKCSAAD-LPEHQGNL 347
LA+K + K+ G YLQ L ++ + S + + EVDP++ ++ L E+Q NL
Sbjct: 1280 LASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNL 1339
Query: 348 KMCCELAFCKIINSYCVFPRELKEV-FASWRQECSS------------RGRPDISERL-- 392
E F II+S FP +L+ V ++ C S + +S+R
Sbjct: 1340 LQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQ 1399
Query: 393 -----ISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKE 447
+ +++FLRF+ PAI+SP +L + P R R L L++K+ Q++AN F +KE
Sbjct: 1400 NSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKE 1458
Query: 448 EYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFE-GYIDLGRELSSLHSLLWEAVSQ 506
E+M N F++ + +RF L+I++ S+ +I G L +LH LLW +
Sbjct: 1459 EHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVL-ALHRLLWNNQEK 1517
Query: 507 LEQSIVS 513
+ Q + S
Sbjct: 1518 IGQYLSS 1524
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 106 bits (264), Expect = 1e-22
Identities = 104/379 (27%), Positives = 169/379 (44%), Gaps = 46/379 (12%)
Query: 126 KTDNVFWGEHFEFHNLP----PLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQ 181
KT W E E +P PLR V L+ + D K N +LG+V ++ +
Sbjct: 174 KTRFPHWDEVLELREMPGAPSPLR---VELW-DWDMVGK---NDFLGMVEFSPKTLQQKP 226
Query: 182 FVEKWYPVVTPNPKGGKGPGP---MIRIKARYQTITILPMEMYKEFAEHITNHYLGLC-- 236
+ W+ ++ P P+ + G +R+K R +LP + Y+ E + G
Sbjct: 227 -PKGWFRLL-PFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEE 284
Query: 237 ------AALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRE 290
A LE + ++++A+ LV + G FL L EV R D + +FR
Sbjct: 285 DTASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMD-PNTLFRS 343
Query: 291 NTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAAD---------LP 341
N+LA+K++E+++KLVG YL + L I ++E + E+DP K L
Sbjct: 344 NSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALS 403
Query: 342 EHQ------GNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSR----GRPDISER 391
E Q G L I+ S P ++ F + R D+
Sbjct: 404 EEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYL 463
Query: 392 LISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAK--FGSKEEY 449
IS LFLRF PAI++P LF+L ++ D +T+R+L L+AK Q++ N + KE +
Sbjct: 464 AISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELW 523
Query: 450 MSFMNQFLEHEWTNMQRFL 468
M+ ++ FL + ++ FL
Sbjct: 524 MAPLHPFLLQCVSRVRDFL 542
Score = 31.6 bits (70), Expect = 4.2
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 5/54 (9%)
Query: 91 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFH 139
L + V+E + LPAK C + +DD + ART ++ FWGE + H
Sbjct: 7 LNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60
>gi|116089337 IQ motif containing GTPase activating protein 2 [Homo
sapiens]
Length = 1575
Score = 53.9 bits (128), Expect = 8e-07
Identities = 74/301 (24%), Positives = 121/301 (40%), Gaps = 35/301 (11%)
Query: 269 LTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYE-SDEN 327
L L+ V D++ LI N +E Y V Q L+ GE K Y+ + E
Sbjct: 981 LRQLLAPVVKEIIDDKSLIINTNP-----VEVYKAWVNQ--LETQTGEASKLPYDVTTEQ 1033
Query: 328 CEVDPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPD 387
P + + NL+ + II+S + P L+ + + + PD
Sbjct: 1034 ALTYPEVKNKLEASIE--NLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKF-PD 1090
Query: 388 ISE----RLISASLFLRFLCPAIMSPSLFNLL------QEYPDDRTARTLTLIAKVTQNL 437
+E +++ L+ R++ PAI++P F+++ Q D R R L +AKV Q+
Sbjct: 1091 ATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQR--RNLGSVAKVLQHA 1148
Query: 438 ANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLG------- 490
A+ F + E++S MN +L + +++ E N + Y DL
Sbjct: 1149 ASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVI 1208
Query: 491 ----RELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQL-PGTNDLAS 545
E+ S HSLL E + L L L +V T S G G + P + A+
Sbjct: 1209 YISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKAN 1268
Query: 546 T 546
T
Sbjct: 1269 T 1269
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 50.8 bits (120), Expect = 7e-06
Identities = 83/341 (24%), Positives = 130/341 (38%), Gaps = 55/341 (16%)
Query: 599 PARSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQA------ 652
P+ S+ EA++ ++++ G + +M + R+ G A S + + + G A
Sbjct: 702 PSNSTRLPEASQAHVRVSPGQAAPAMA--RPRRSRHGPASSSSSSEGEDSAGPARPSQKR 759
Query: 653 ----AAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSEG----APGRPQ----LLA 700
A AQ VA W A A+ RA G PG P+ LA
Sbjct: 760 PRCSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVGSAQSRLGPGPPRGHSKALA 819
Query: 701 PLSFQNPVYQMAAG------LPLS------PRGLGDSGSEGHSSLSSHSNSEELAAA--A 746
P + P + AG +PL+ PRG GD+ +S S S A A
Sbjct: 820 PQAALIPEEECLAGDWLELDMPLTRSRRPRPRGTGDNRRPSSTSGSDSEESRPRARAKQV 879
Query: 747 KLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNS-AGPQRRIDQPPPPPPPPPP 805
+L + + + P LA +E G P+ PR + +G QP P PPPP
Sbjct: 880 RLTCMQSCSAPVNAGPSSLA------SEPPGSPSTPRVSEPSGDSSAAGQPLGPAPPPPI 933
Query: 806 APRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQ 865
R + +L P P S S + W L +Q++ + L PR ++
Sbjct: 934 RVRVQVQDHL---FLIPVPHSSDTHSVA--W------LAEQAAQRYYQTCGLLPRLTLRK 982
Query: 866 GPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLR 906
+ ++P L +L N ++L + PP DR R
Sbjct: 983 EGALLAPQDL---IPDVLQSNDEVLAEVTSWDLPPLTDRYR 1020
>gi|40353727 synaptopodin isoform A [Homo sapiens]
Length = 903
Score = 50.1 bits (118), Expect = 1e-05
Identities = 77/282 (27%), Positives = 101/282 (35%), Gaps = 48/282 (17%)
Query: 575 RLPSPT-PENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDARTL 633
R SP P + DL + PSPA + P L + G SL +
Sbjct: 586 RAASPAKPSSLDLVPNLPKGALPPSPALPRP--SRSSPGLYTSPGQDSLQPTAVSP---- 639
Query: 634 DGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSEGAP 693
P G D+ P A + P + AG+ R PT+P + GA
Sbjct: 640 ------PYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGAS 693
Query: 694 GRPQLLAPLSFQNPVYQMAAGLPLS-------PRGLGDSGSEGHSSLSSHSNSEELAAAA 746
P L P ++ G +S P + S SE S +E +
Sbjct: 694 RPPSSLDGWVSPGP-WEPGRGSSMSSPPPLPPPPPMSPSWSE-RSVSPLRPETEARPPSR 751
Query: 747 KLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPA 806
+L + LAR ARR+ + G PR S P R PPPPPPPPPP
Sbjct: 752 QLQAL------LARNIINAARRKSASPRSAGAEN-PRPFS--PPRA---PPPPPPPPPPP 799
Query: 807 PRGRTPPNLLSTLQYPRPSSGTLASA-------SPDWVGPST 841
PR R+P Q RP S + A SP GPS+
Sbjct: 800 PRMRSP-------QPARPGSAAVPGAAFAPIPRSPLPAGPSS 834
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 48.9 bits (115), Expect = 3e-05
Identities = 32/135 (23%), Positives = 68/135 (50%), Gaps = 4/135 (2%)
Query: 903 DRLRSKDELSQA----EKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLE 958
D + SKD++ ++ EK L+ ++ +LEE E + E+ +L + QA
Sbjct: 1508 DLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567
Query: 959 EGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLD 1018
+ E L+ + E + + K ++ ++ +E EL+ + + AV +++K+ + A +D
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID 1627
Query: 1019 AANARLMSALTQLKE 1033
+AN A+ QL++
Sbjct: 1628 SANKNRDEAIKQLRK 1642
Score = 38.1 bits (87), Expect = 0.044
Identities = 35/140 (25%), Positives = 71/140 (50%), Gaps = 13/140 (9%)
Query: 903 DRLRSKDEL-SQAEKDLAVLQDKLRISTKKLEEYETL---FKCQEETTQKLVLEYQARLE 958
+RL + L SQ + LQ++L+ T+ E E L +++ +++ + +AR+E
Sbjct: 866 NRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVE 925
Query: 959 EGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQ----AAVDSKQKIIDAQEKRI 1014
E EER + Q +K K + + +EE+L+++ + Q V ++ K+ +E++I
Sbjct: 926 EEEERCQHLQAEK----KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQI 981
Query: 1015 ASLDAANARLMSALTQLKER 1034
L+ N +L L++R
Sbjct: 982 I-LEDQNCKLAKEKKLLEDR 1000
Score = 35.4 bits (80), Expect = 0.29
Identities = 38/163 (23%), Positives = 77/163 (47%), Gaps = 16/163 (9%)
Query: 890 LEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQD---KLRISTKKLE----EYETLFKCQ 942
LE+E +++ ++ +L + E++ +L+D KL K LE E+ T +
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 943 EETTQ---KLVLEYQARLEEGEERLRR------QQEDKDIQMKGIISRLMSVEEELKKDH 993
EE ++ KL +++A + + EERLRR + E +++G + L EL+
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 994 AEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYS 1036
AE++ + K++ + A R+ A + + +L+ + S
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQIS 1114
Score = 33.5 bits (75), Expect = 1.1
Identities = 38/167 (22%), Positives = 72/167 (43%), Gaps = 13/167 (7%)
Query: 902 RDRLRSKDELSQ-AEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG 960
R++L ++E EK +A L ++ KK+E+ + EE +KL + + +
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401
Query: 961 EERLRRQQEDKDIQMKGIISRLMSVEEEL--KKDHAEMQAA-VDSKQKIID---AQEKRI 1014
EE++ +++ +RL ++L DH A ++ KQK D A+EK I
Sbjct: 1402 EEKVAAYD-----KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 1015 ASLDAANARLMSALTQLKERYSMQARNGISPTNPTKLQITE-NGEFR 1060
++ A A + KE ++ + K ++ N +FR
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503
Score = 31.2 bits (69), Expect = 5.4
Identities = 29/130 (22%), Positives = 57/130 (43%), Gaps = 19/130 (14%)
Query: 906 RSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLR 965
+S + S+ KD + L+ +L+ + + L QEE QKL L + + E E+
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELL---------QEENRQKLSLSTKLKQVEDEKNSF 1341
Query: 966 RQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLM 1025
R+Q +++ + K L+K A + A V +K ++ + + + +L
Sbjct: 1342 REQLEEEEEAK----------HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 1026 SALTQLKERY 1035
L L +R+
Sbjct: 1392 KDLEGLSQRH 1401
>gi|7657387 CCR4-NOT transcription complex, subunit 3 [Homo sapiens]
Length = 753
Score = 48.9 bits (115), Expect = 3e-05
Identities = 82/307 (26%), Positives = 112/307 (36%), Gaps = 55/307 (17%)
Query: 590 TRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDART------LDGEAGSPAGP 643
T SS + PSPA ++ E +E D + G + S V A+ + SPA P
Sbjct: 265 TSSSPIPPSPANCTT--ENSEDDKK--RGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVP 320
Query: 644 DVLPTDGQAAAAQLVA-----GWPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGR-PQ 697
P+ AA+ L G PA A P + G + P + G P Q
Sbjct: 321 PTYPSGPPPAASALSTTPGNNGVPAPAAPPSALG-------PKASPAPSHNSGTPAPYAQ 373
Query: 698 LLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEE 757
+AP + P + P G G GS G S SS SNS A K ++ +
Sbjct: 374 AVAPPAPSGPSTTQPRPPSVQPSGGGGGGSGGGGS-SSSSNSSAGGGAGKQNGATSYSSV 432
Query: 758 LARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPP-----PPPPPPPAPRGRTP 812
+A P E+A L+ GG + GP PPP P P G P
Sbjct: 433 VADSPAEVA-----LSSSGGNNA--SSQALGPPSGPHNPPPSTSKEPSAAAPTGAGGVAP 485
Query: 813 --------PNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHK 864
P+LL L PSS T + + G Q S+ +PE+K
Sbjct: 486 GSGNNSGGPSLLVPLPVNPPSSPTPSFSDAKAAGALLNGPPQFST----APEIK------ 535
Query: 865 QGPSPVS 871
P P+S
Sbjct: 536 -APEPLS 541
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 48.1 bits (113), Expect = 4e-05
Identities = 44/174 (25%), Positives = 65/174 (37%), Gaps = 16/174 (9%)
Query: 762 PGELARRQMSLTEKGGQ---PTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLST 818
PG++ +Q + Q PT P GP + Q P P PPP P PP+
Sbjct: 446 PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPG 505
Query: 819 LQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRT 878
P P A SP G + QQ S+K + Q PSP P+A T
Sbjct: 506 STKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSA----------QQPSPAKPSAQQST 555
Query: 879 AAWLLTMNAQLLEDEGLGP---DPPHRDRLRSKDELSQAEKDLAVLQDKLRIST 929
T + + L+ + P PP + ++ L + L + +K +T
Sbjct: 556 KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNT 609
Score = 39.7 bits (91), Expect = 0.015
Identities = 16/30 (53%), Positives = 18/30 (60%)
Query: 796 PPPPPPPPPPAPRGRTPPNLLSTLQYPRPS 825
PPPPPPPPPP P PP L P+P+
Sbjct: 2407 PPPPPPPPPPPPPPPPPPPPLPPPTSPKPT 2436
Score = 38.5 bits (88), Expect = 0.034
Identities = 14/19 (73%), Positives = 14/19 (73%)
Query: 795 QPPPPPPPPPPAPRGRTPP 813
QPPPPPPPPPP P PP
Sbjct: 2404 QPPPPPPPPPPPPPPPPPP 2422
Score = 37.7 bits (86), Expect = 0.058
Identities = 16/28 (57%), Positives = 16/28 (57%)
Query: 786 SAGPQRRIDQPPPPPPPPPPAPRGRTPP 813
SA P PPPPPPPPPP P PP
Sbjct: 2402 SAQPPPPPPPPPPPPPPPPPPPPPPLPP 2429
Score = 36.6 bits (83), Expect = 0.13
Identities = 16/35 (45%), Positives = 16/35 (45%)
Query: 779 PTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPP 813
P PR I PPPPPPPPP P PP
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPP 2421
Score = 35.8 bits (81), Expect = 0.22
Identities = 26/88 (29%), Positives = 36/88 (40%), Gaps = 2/88 (2%)
Query: 745 AAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPP 804
A++L S S + L +P R S + QP P P PPPPP PPP
Sbjct: 2373 ASQLPSGSPSVSSLPAKPRPFFRS--SSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPP 2430
Query: 805 PAPRGRTPPNLLSTLQYPRPSSGTLASA 832
+P+ P T+ P ++ L A
Sbjct: 2431 TSPKPTILPKKKLTVASPVTTATPLFDA 2458
Score = 35.0 bits (79), Expect = 0.38
Identities = 29/105 (27%), Positives = 43/105 (40%), Gaps = 12/105 (11%)
Query: 778 QPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYP-RPSSGTLASASPDW 836
QPT + + P QP P PP P+ + T++ P +P T A P
Sbjct: 308 QPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQP-- 365
Query: 837 VGPSTRLRQQSSSSKGDSPELKPRAVHK---------QGPSPVSP 872
+GP+ QQ+ S K S + P+A+ + Q P P P
Sbjct: 366 LGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKP 410
Score = 31.6 bits (70), Expect = 4.2
Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 10/122 (8%)
Query: 719 PRGLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQ 778
P GL + + G + + S S A S +EE R+ + R L +
Sbjct: 13 PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP 72
Query: 779 PTVPRQNSAGPQRRIDQPPPP-----PPPP-----PPAPRGRTPPNLLSTLQYPRPSSGT 828
P S ++ +D PP PP P P + RT S + P S T
Sbjct: 73 PAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST 132
Query: 829 LA 830
++
Sbjct: 133 IS 134
Score = 31.6 bits (70), Expect = 4.2
Identities = 29/116 (25%), Positives = 43/116 (37%), Gaps = 23/116 (19%)
Query: 778 QPTVPRQNSAGPQRRIDQPPPPPPPP---------PPAPRGRTPPNLLSTLQYPRPSSGT 828
Q T P++++A Q P P PPP P+ + + PP S + P +
Sbjct: 680 QQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPS 739
Query: 829 LAS------------ASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSP 872
+ S P V P+T L SSSS P++ V Q +P
Sbjct: 740 VPSEQDKAPVADDKPKQPKMVKPTTDL--VSSSSATTKPDIPSSKVQSQAEEKTTP 793
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 48.1 bits (113), Expect = 4e-05
Identities = 44/174 (25%), Positives = 65/174 (37%), Gaps = 16/174 (9%)
Query: 762 PGELARRQMSLTEKGGQ---PTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLST 818
PG++ +Q + Q PT P GP + Q P P PPP P PP+
Sbjct: 446 PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPG 505
Query: 819 LQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRT 878
P P A SP G + QQ S+K + Q PSP P+A T
Sbjct: 506 STKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSA----------QQPSPAKPSAQQST 555
Query: 879 AAWLLTMNAQLLEDEGLGP---DPPHRDRLRSKDELSQAEKDLAVLQDKLRIST 929
T + + L+ + P PP + ++ L + L + +K +T
Sbjct: 556 KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNT 609
Score = 39.7 bits (91), Expect = 0.015
Identities = 16/30 (53%), Positives = 18/30 (60%)
Query: 796 PPPPPPPPPPAPRGRTPPNLLSTLQYPRPS 825
PPPPPPPPPP P PP L P+P+
Sbjct: 2407 PPPPPPPPPPPPPPPPPPPPLPPPTSPKPT 2436
Score = 38.5 bits (88), Expect = 0.034
Identities = 14/19 (73%), Positives = 14/19 (73%)
Query: 795 QPPPPPPPPPPAPRGRTPP 813
QPPPPPPPPPP P PP
Sbjct: 2404 QPPPPPPPPPPPPPPPPPP 2422
Score = 37.7 bits (86), Expect = 0.058
Identities = 16/28 (57%), Positives = 16/28 (57%)
Query: 786 SAGPQRRIDQPPPPPPPPPPAPRGRTPP 813
SA P PPPPPPPPPP P PP
Sbjct: 2402 SAQPPPPPPPPPPPPPPPPPPPPPPLPP 2429
Score = 36.6 bits (83), Expect = 0.13
Identities = 16/35 (45%), Positives = 16/35 (45%)
Query: 779 PTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPP 813
P PR I PPPPPPPPP P PP
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPP 2421
Score = 35.8 bits (81), Expect = 0.22
Identities = 26/88 (29%), Positives = 36/88 (40%), Gaps = 2/88 (2%)
Query: 745 AAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPP 804
A++L S S + L +P R S + QP P P PPPPP PPP
Sbjct: 2373 ASQLPSGSPSVSSLPAKPRPFFRS--SSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPP 2430
Query: 805 PAPRGRTPPNLLSTLQYPRPSSGTLASA 832
+P+ P T+ P ++ L A
Sbjct: 2431 TSPKPTILPKKKLTVASPVTTATPLFDA 2458
Score = 35.0 bits (79), Expect = 0.38
Identities = 29/105 (27%), Positives = 43/105 (40%), Gaps = 12/105 (11%)
Query: 778 QPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYP-RPSSGTLASASPDW 836
QPT + + P QP P PP P+ + T++ P +P T A P
Sbjct: 308 QPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQP-- 365
Query: 837 VGPSTRLRQQSSSSKGDSPELKPRAVHK---------QGPSPVSP 872
+GP+ QQ+ S K S + P+A+ + Q P P P
Sbjct: 366 LGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKP 410
Score = 31.6 bits (70), Expect = 4.2
Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 10/122 (8%)
Query: 719 PRGLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQ 778
P GL + + G + + S S A S +EE R+ + R L +
Sbjct: 13 PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP 72
Query: 779 PTVPRQNSAGPQRRIDQPPPP-----PPPP-----PPAPRGRTPPNLLSTLQYPRPSSGT 828
P S ++ +D PP PP P P + RT S + P S T
Sbjct: 73 PAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST 132
Query: 829 LA 830
++
Sbjct: 133 IS 134
Score = 31.6 bits (70), Expect = 4.2
Identities = 29/116 (25%), Positives = 43/116 (37%), Gaps = 23/116 (19%)
Query: 778 QPTVPRQNSAGPQRRIDQPPPPPPPP---------PPAPRGRTPPNLLSTLQYPRPSSGT 828
Q T P++++A Q P P PPP P+ + + PP S + P +
Sbjct: 680 QQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPS 739
Query: 829 LAS------------ASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSP 872
+ S P V P+T L SSSS P++ V Q +P
Sbjct: 740 VPSEQDKAPVADDKPKQPKMVKPTTDL--VSSSSATTKPDIPSSKVQSQAEEKTTP 793
>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
Length = 3230
Score = 48.1 bits (113), Expect = 4e-05
Identities = 84/315 (26%), Positives = 119/315 (37%), Gaps = 46/315 (14%)
Query: 507 LEQSIVSKLGPLPRILRDVHTALSTPGSGQLP-GTNDLASTPGSGSSSISAGLQKMVIEN 565
L S L PLP +L A S Q P +STPG+ +S S +
Sbjct: 1598 LAPSPAPPLAPLP-VLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPV-- 1654
Query: 566 DLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMV 625
L+ T LP+P P P P+ +S+ + A P L GG S S
Sbjct: 1655 -LAPSSTQTMLPAPVPS--------------PLPSPASTQTLALAPALAPTLGGSSPS-- 1697
Query: 626 DLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAG------LATVRRA 679
+TL G+P GP T A+ LV P A ++LA T+ A
Sbjct: 1698 -----QTLSLGTGNPQGPFPTQTLSLTPASSLV---PTPAQTLSLAPGPPLGPTQTLSLA 1749
Query: 680 GQTPTTPGTSEG-APGRPQLLAPLSFQNPVYQMAA--GLPLSPRGLGDSGSEGHSSLSSH 736
P P + G AP LAP S + A+ L LSP + G +L+
Sbjct: 1750 PAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALA 1809
Query: 737 SNSEELAAAAKLGSFSTAAEELARRPGELARRQM-------SLTEKGGQPTVPRQNSAGP 789
S + + A++ S +A A P + R +LT + G P+ P ++
Sbjct: 1810 PASTQ-SPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFG 1868
Query: 790 QRRIDQPPPPPPPPP 804
R + PPPPP P
Sbjct: 1869 GPRPRRQPPPPPRSP 1883
Score = 39.3 bits (90), Expect = 0.020
Identities = 92/361 (25%), Positives = 124/361 (34%), Gaps = 83/361 (22%)
Query: 538 PGTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDL-------FFVT 590
P AS PG+ +IS+ L + + L G P P P + L V
Sbjct: 1381 PSPEVSASAPGAAPLTISSPLH---VPSSLPGPASS---PMPIPNSSPLASPVSSTVSVP 1434
Query: 591 RSSGVQ-------PSPARSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGP 643
SS + P+PA + + P A+G L+ V A + +P P
Sbjct: 1435 LSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPA---APGPP 1491
Query: 644 DVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLS 703
+ P+ +A+ L G LAT + T PG P LLAP S
Sbjct: 1492 SLAPSGASPSASALTLG------------LATAPSLSSSQT--------PGHPLLLAPTS 1531
Query: 704 FQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPG 763
P G +S + + S L A+ L S +A A
Sbjct: 1532 SHVP---------------------GLNSTVAPACSPVLVPASALASPFPSAPNPAPAQA 1570
Query: 764 ELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPP---PAPRGRTPPNLLST-- 818
L S ++ P P A PQ I P P PP P AP P L S+
Sbjct: 1571 SLLAPASSASQALATPLAP---MAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQT 1627
Query: 819 ---LQYPRPSSGT-LASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNA 874
+ P + GT LASASP V T + SS+ + P V PSP S
Sbjct: 1628 PVPVMAPSSTPGTSLASASP--VPAPTPVLAPSSTQ-----TMLPAPVPSPLPSPASTQT 1680
Query: 875 L 875
L
Sbjct: 1681 L 1681
>gi|13129104 coiled-coil domain containing 86 [Homo sapiens]
Length = 360
Score = 48.1 bits (113), Expect = 4e-05
Identities = 82/349 (23%), Positives = 129/349 (36%), Gaps = 58/349 (16%)
Query: 677 RRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSH 736
R G P+ G+P RP +P S P Q AGL SP+G + G+
Sbjct: 43 REPGSPPSVQRAGLGSPERPPKTSPGS---PRLQQGAGLE-SPQGQPEPGAAS----PQR 94
Query: 737 SNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQP 796
L + + +S + +P E A + + P Q
Sbjct: 95 QQDLHLESPQRQPEYSPESPRCQPKPSEEAPKCSQDQGVLASELAQNKEELTPGAPQHQL 154
Query: 797 PPPPPPPPPAPRGRTP------PNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSS 850
PP P P P P + P P L T + P G + P G + +
Sbjct: 155 PPVPGSPEPYPGQQAPGPEPSQPLLELTPRAPGSPRGQHEPSKPPPAGETVTGGFGAKKR 214
Query: 851 KGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDE 910
KG S + + PV P ++ ++ +D RSK
Sbjct: 215 KGSSSQAPASKKLNKEELPVIPKGKPKSG--------RVWKD-------------RSKKR 253
Query: 911 LSQAEKDLAVLQDK-LRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQE 969
SQ +LQDK LR S ++ K +E +KL ++ LEE +E RR+QE
Sbjct: 254 FSQ------MLQDKPLRTSWQR--------KMKERQERKLAKDFARHLEEEKE--RRRQE 297
Query: 970 DKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLD 1018
K + + + RL E E K AE+ + + K+ A++K++ S++
Sbjct: 298 KKQRRAENLKRRL---ENERK---AEVVQVIRNPAKLKRAKKKQLRSIE 340
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 47.8 bits (112), Expect = 6e-05
Identities = 61/245 (24%), Positives = 99/245 (40%), Gaps = 30/245 (12%)
Query: 779 PTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVG 838
P +P +SAGP PPPPPPPP P PPN P P LA P
Sbjct: 688 PPLPPPSSAGP--------PPPPPPPPLPNSPAPPNPGGPPPAPPPPG--LAPPPP---- 733
Query: 839 PSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNA-----QLLEDE 893
P SSSS+ PR + P+ P R + NA LE+
Sbjct: 734 PGLFFGLGSSSSQ------CPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEP 787
Query: 894 GLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEY 953
+ DP + L SKD Q +K L+ +K + KK+ + L + +T L+
Sbjct: 788 DI-RDPSEFEYLFSKDTTQQKKKPLSETYEK-KNKVKKI--IKLLDGKRSQTVGILISSL 843
Query: 954 QARLEEGEERLRRQQED-KDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEK 1012
+++ ++ + + D++ + + E+EL K + + + + K++D E+
Sbjct: 844 HLEMKDIQQAIFNVDDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQ 903
Query: 1013 RIASL 1017
+ L
Sbjct: 904 FLHEL 908
Score = 30.8 bits (68), Expect = 7.1
Identities = 27/92 (29%), Positives = 37/92 (40%), Gaps = 9/92 (9%)
Query: 782 PRQNSAGPQRRIDQPPPPP-PPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS 840
P + A Q++ PPP PPPPP P G L +L P P +++ P P
Sbjct: 633 PMEGMASNQQKALPPPPASIPPPPPLPSG------LGSLS-PAPPMPPVSAGPPLPPPPP 685
Query: 841 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSP 872
SS G P P + P+P +P
Sbjct: 686 PPPPLPPPSSAGPPPPPPPPPL-PNSPAPPNP 716
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 47.8 bits (112), Expect = 6e-05
Identities = 35/136 (25%), Positives = 69/136 (50%), Gaps = 6/136 (4%)
Query: 903 DRLRSKDELS----QAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLE 958
D + SKD++ + EK L+ ++ +LEE E + E+ +L + QA
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 959 EGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKI-IDAQEKRIASL 1017
+ E L+ + E + + + +I ++ +E EL+ + + AV SK+K+ ID ++ A +
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLE-AQI 1633
Query: 1018 DAANARLMSALTQLKE 1033
+AAN + QL++
Sbjct: 1634 EAANKARDEVIKQLRK 1649
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/110 (26%), Positives = 60/110 (54%), Gaps = 10/110 (9%)
Query: 916 KDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQAR-LEEGEERLRRQQEDKDIQ 974
KD A L+ +L+ + + L QEET QKL L + R LEE + L+ QQE+++
Sbjct: 1308 KDAASLESQLQDTQELL---------QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 975 MKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARL 1024
K + ++++++ +L ++ + + + + +A++K + +A + RL
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL 1408
Score = 32.7 bits (73), Expect = 1.9
Identities = 31/139 (22%), Positives = 64/139 (46%), Gaps = 13/139 (9%)
Query: 906 RSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQ--------ARL 957
R ++EL +++L +++K +LEE E K Q+ +K +L Q A
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELEEMER--KHQQLLEEKNILAEQLQAETELFAEA 906
Query: 958 EEGEERLRRQQEDKDIQMKGIISRLMSVEEE---LKKDHAEMQAAVDSKQKIIDAQEKRI 1014
EE RL ++++ + + + SR+ EE L+ + +MQA + ++ +D +E
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966
Query: 1015 ASLDAANARLMSALTQLKE 1033
L + + +++E
Sbjct: 967 QKLQLEKVTAEAKIKKMEE 985
Score = 32.7 bits (73), Expect = 1.9
Identities = 24/121 (19%), Positives = 62/121 (51%), Gaps = 10/121 (8%)
Query: 920 VLQDKLRISTK---KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMK 976
+L ++L+ T+ + EE +++ ++++ + ++R+EE EER + Q +K K
Sbjct: 891 ILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK----K 946
Query: 977 GIISRLMSVEEELKKDHA---EMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKE 1033
+ + + +EE+L ++ ++Q + + I E+ I L+ N++ + +++
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006
Query: 1034 R 1034
R
Sbjct: 1007 R 1007
Score = 30.4 bits (67), Expect = 9.3
Identities = 31/145 (21%), Positives = 67/145 (46%), Gaps = 23/145 (15%)
Query: 915 EKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQA-------------RLEEGE 961
EK + LQ +L + KK+++ + EE +KL+ + +A +LE+ +
Sbjct: 1363 EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTK 1422
Query: 962 ERLRRQQEDKDIQM---KGIISRLMSVEEELKKDHAEMQA-----AVDSKQKIIDAQEKR 1013
RL+++ +D + + + + S L +++ + AE ++ A + + +A+EK
Sbjct: 1423 NRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKE 1482
Query: 1014 IASLDAANARLMSALTQLKERYSMQ 1038
+L AR + + KE + Q
Sbjct: 1483 TKALSL--ARALEEALEAKEEFERQ 1505
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,232,625
Number of Sequences: 37866
Number of extensions: 2611030
Number of successful extensions: 34561
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 526
Number of HSP's successfully gapped in prelim test: 1356
Number of HSP's that attempted gapping in prelim test: 17406
Number of HSP's gapped (non-prelim): 9794
length of query: 1065
length of database: 18,247,518
effective HSP length: 113
effective length of query: 952
effective length of database: 13,968,660
effective search space: 13298164320
effective search space used: 13298164320
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.