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Search of human proteins with 41054864
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41054864 regulating synaptic membrane exocytosis 1 [Homo
sapiens]
(1692 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapi... 3385 0.0
gi|154354983 regulating synaptic membrane exocytosis 2 isoform a... 1149 0.0
gi|154354981 regulating synaptic membrane exocytosis 2 isoform b... 938 0.0
gi|48476344 regulating synaptic membrane exocytosis 3 [Homo sapi... 387 e-107
gi|33667061 regulating synaptic membrane exocytosis 4 [Homo sapi... 315 2e-85
gi|150170670 piccolo isoform 2 [Homo sapiens] 141 6e-33
gi|150378539 piccolo isoform 1 [Homo sapiens] 141 6e-33
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 86 3e-16
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 75 4e-13
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 74 2e-12
gi|193804862 synaptotagmin-like 4 [Homo sapiens] 72 5e-12
gi|193804860 synaptotagmin-like 4 [Homo sapiens] 72 5e-12
gi|14249614 synaptotagmin-like 1 [Homo sapiens] 72 6e-12
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 71 8e-12
gi|238550198 synaptotagmin III [Homo sapiens] 70 1e-11
gi|238550196 synaptotagmin III [Homo sapiens] 70 1e-11
gi|14150054 synaptotagmin III [Homo sapiens] 70 1e-11
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens] 69 3e-11
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 69 3e-11
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 69 3e-11
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 69 4e-11
gi|211059429 synaptotagmin II [Homo sapiens] 68 9e-11
gi|31543670 synaptotagmin II [Homo sapiens] 68 9e-11
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens] 67 1e-10
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens] 67 1e-10
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens] 67 1e-10
gi|47078261 double C2-like domains, alpha [Homo sapiens] 67 2e-10
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 67 2e-10
gi|4506067 protein kinase C, alpha [Homo sapiens] 66 3e-10
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens] 66 3e-10
>gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapiens]
Length = 1692
Score = 3385 bits (8776), Expect = 0.0
Identities = 1692/1692 (100%), Positives = 1692/1692 (100%)
Query: 1 MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRD 60
MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRD
Sbjct: 1 MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRD 60
Query: 61 MAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICH 120
MAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICH
Sbjct: 61 MAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICH 120
Query: 121 KTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFF 180
KTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFF
Sbjct: 121 KTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFF 180
Query: 181 GSGPQQTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPD 240
GSGPQQTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPD
Sbjct: 181 GSGPQQTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPD 240
Query: 241 RSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQP 300
RSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQP
Sbjct: 241 RSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQP 300
Query: 301 VEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPN 360
VEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPN
Sbjct: 301 VEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPN 360
Query: 361 LARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARAS 420
LARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARAS
Sbjct: 361 LARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARAS 420
Query: 421 PPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSS 480
PPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSS
Sbjct: 421 PPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSS 480
Query: 481 AVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVST 540
AVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVST
Sbjct: 481 AVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVST 540
Query: 541 PEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRV 600
PEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRV
Sbjct: 541 PEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRV 600
Query: 601 ILNKRTTMPKDSGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWN 660
ILNKRTTMPKDSGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWN
Sbjct: 601 ILNKRTTMPKDSGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWN 660
Query: 661 GKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKME 720
GKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKME
Sbjct: 661 GKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKME 720
Query: 721 RPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNP 780
RPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNP
Sbjct: 721 RPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNP 780
Query: 781 YVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQE 840
YVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQE
Sbjct: 781 YVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQE 840
Query: 841 EESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQR 900
EESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQR
Sbjct: 841 EESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQR 900
Query: 901 SQRISDSDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRSVSPHRGN 960
SQRISDSDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRSVSPHRGN
Sbjct: 901 SQRISDSDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRSVSPHRGN 960
Query: 961 DQGKPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSEL 1020
DQGKPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSEL
Sbjct: 961 DQGKPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSEL 1020
Query: 1021 LMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTKTKSVTRQ 1080
LMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTKTKSVTRQ
Sbjct: 1021 LMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTKTKSVTRQ 1080
Query: 1081 DISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSLHSPERERGRWSPSL 1140
DISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSLHSPERERGRWSPSL
Sbjct: 1081 DISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSLHSPERERGRWSPSL 1140
Query: 1141 DRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPR 1200
DRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPR
Sbjct: 1141 DRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPR 1200
Query: 1201 ATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPAD 1260
ATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPAD
Sbjct: 1201 ATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPAD 1260
Query: 1261 TSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYS 1320
TSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYS
Sbjct: 1261 TSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYS 1320
Query: 1321 KYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFT 1380
KYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFT
Sbjct: 1321 KYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFT 1380
Query: 1381 PKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVA 1440
PKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVA
Sbjct: 1381 PKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVA 1440
Query: 1441 IVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSE 1500
IVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSE
Sbjct: 1441 IVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSE 1500
Query: 1501 GNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRA 1560
GNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRA
Sbjct: 1501 GNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRA 1560
Query: 1561 RSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQ 1620
RSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQ
Sbjct: 1561 RSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQ 1620
Query: 1621 VIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSS 1680
VIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSS
Sbjct: 1621 VIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSS 1680
Query: 1681 LESSTGPPCIRS 1692
LESSTGPPCIRS
Sbjct: 1681 LESSTGPPCIRS 1692
>gi|154354983 regulating synaptic membrane exocytosis 2 isoform a
[Homo sapiens]
Length = 1349
Score = 1149 bits (2971), Expect = 0.0
Identities = 629/1087 (57%), Positives = 761/1087 (70%), Gaps = 109/1087 (10%)
Query: 1 MSSAVGPRG---PRPPTVPPPMQ-ELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKC 56
MS+ VGPRG P P PP+Q E+PDLSHLTEEER II+AVMDRQK+EEEKE+++LK
Sbjct: 1 MSAPVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLK- 59
Query: 57 VVRDMAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTC 116
+LHQQFE YKEQV+K+GEE+++ Q E K DAPTC
Sbjct: 60 --------------------------KLHQQFEMYKEQVKKMGEESQQQQ-EQKGDAPTC 92
Query: 117 GICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSG 176
GICHKTKFADGCGH CSYC+TKFCARCGGRVSLRSN VMWVCNLCRKQQEILTKSG
Sbjct: 93 GICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNK----VMWVCNLCRKQQEILTKSG 148
Query: 177 AWFFGSG---PQQTSQDGTLSDTATGA-GSEVPREKKARLQERSRSQTPLSTAAASSQDA 232
AWF+ SG PQQ Q G E P+EKK +L E+++ Q P S D
Sbjct: 149 AWFYNSGSNTPQQPDQK-----VLRGLRNEEAPQEKKPKLHEQTQFQGP-------SGDL 196
Query: 233 APPSAPPDRSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLS-EQNGKGALKSERK 291
+ P+ RS G ++Q S+ +RK++P +S +QN + + ER+
Sbjct: 197 SVPAVEKSRSHGL--TRQHSIKNGSGVKHHIASDIASDRKRSPSVSRDQNRRYDQREERE 254
Query: 292 R----------VPKTSAQPVEGA-------VEERERKERRESRRLEKGRSQDY---PDTP 331
+P++ + + E+ + R+S R S++Y +
Sbjct: 255 EYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRSHRHSKEYIVDDEDV 314
Query: 332 EKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHS 391
E RDE E+QR+EE+YQ+RYRSDPNLARYPVKP P E+QMR+HA VSRARHERRHS
Sbjct: 315 ESRDE-----YERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHS 369
Query: 392 DVALPRTEAG----AALPEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPG--AKQLT 445
DV+L + + L + ++ + R + ++ R+YS ERT E + P A++ T
Sbjct: 370 DVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTT 429
Query: 446 NHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQ 505
NHSPP PR P+P + P+L+ + LRKQ LDPSSAV RK KREK+ETMLRNDSLSSDQ
Sbjct: 430 NHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAV--RKTKREKMETMLRNDSLSSDQ 487
Query: 506 SESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYY 565
SESVRP PPKPH+SK+GGK RQ+S+SSSEEE STPEYTSC+DVE+ESESVSEKGD+DY
Sbjct: 488 SESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSEKGDMDYN 547
Query: 566 WLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRT---TMPKDSGALLGLKVVG 622
WLD +WHS E SP+S HPVTWQPSK+GDRLIGR++LNKR ++P+DSGA+LGLKVVG
Sbjct: 548 WLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVG 607
Query: 623 GKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSE 682
GKMT+ GRL AFITKVKKGSLAD VGHLR GDEVLEWNG+ L GAT EEVYNIILESK E
Sbjct: 608 GKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPE 667
Query: 683 PQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVL 742
PQVE++VSRPIGDIPRIP+S+H LESSSSSFESQKM+RPSISV SP SPG L+D PQ L
Sbjct: 668 PQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFL 727
Query: 743 PGQLS----------------VKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYF 786
GQLS +KLW+DKVGHQLIV +L A DLP+R DGRPRNPYVK+YF
Sbjct: 728 SGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYF 787
Query: 787 LPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFL 846
LPDRSDK+KRRTKTVKK LEPKWNQTF+YS VHRR+FRERMLEIT+WDQ RV+EEESEFL
Sbjct: 788 LPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFL 847
Query: 847 GEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQRSQRISD 906
GEILIELETALLDDEPHWYKLQTHD SSLPLP PSP+MPRR +HGES +++LQRS+RISD
Sbjct: 848 GEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISD 907
Query: 907 SDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRSVSPHRGNDQGKPR 966
S++SDY+ DDGIGVV YR R+ +S+TL+VPEQ +++H S S SPHR + G+ R
Sbjct: 908 SEVSDYDCDDGIGVVS--DYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTR 965
Query: 967 SRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSELLMLPRA 1026
S P+VP +S + R +R+ T H++ HR D ++D E
Sbjct: 966 SWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRDRDCEAADRQPY 1025
Query: 1027 KRGRSAE 1033
R RS E
Sbjct: 1026 HRSRSTE 1032
Score = 404 bits (1037), Expect = e-112
Identities = 226/377 (59%), Positives = 262/377 (69%), Gaps = 38/377 (10%)
Query: 1327 DQYRSCDNVSAKSSDSD--VSDVSAISRTSSASR---LSSTSFMSEQSERPRGRISSFTP 1381
D++R D+ + D D +D R+ S + L T+ S +ERP + P
Sbjct: 1000 DRHRVMDDHYSPDRDRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMP 1059
Query: 1382 KMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAI 1441
+ R ++ +S +G + T S S T V
Sbjct: 1060 SLMTGRSAPPSPALSRSHPRTGSVQT------SPSSTPVA-------------------- 1093
Query: 1442 VSRRSRSTSQLS-----QTESGHKKLKSTIQRSTETGMAAEMRK-MVRQPSRESTDGSIN 1495
RR R QL ++G KKL+ST+QRSTETG+A EMR M RQ SRESTDGS+N
Sbjct: 1094 -GRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMN 1152
Query: 1496 SYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEV 1555
SYSSEGNLIFPGVRL +DSQFSDFLDGLGPAQLVGRQTLATPAMGDIQ+GM DKKGQLEV
Sbjct: 1153 SYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEV 1212
Query: 1556 EVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQ 1615
E+IRAR L KPGSK+ PAPYVKVYLL+NG CIAKKKT++ARKTL+PLYQQ L F+ESPQ
Sbjct: 1213 EIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQ 1272
Query: 1616 GKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRR 1675
GKVLQ+IVWGDYGRMDHK FMGVAQILL+EL+LS+MVIGW+KLFPPSSLVDPTL PLTRR
Sbjct: 1273 GKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRR 1332
Query: 1676 ASQSSLESSTGPPCIRS 1692
ASQSSLESSTGP RS
Sbjct: 1333 ASQSSLESSTGPSYSRS 1349
Score = 67.0 bits (162), Expect = 1e-10
Identities = 40/127 (31%), Positives = 58/127 (45%), Gaps = 25/127 (19%)
Query: 1149 RIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPRATDQPVIR 1208
R+ H SP+ DR ++R + R+T+Q +
Sbjct: 1003 RVMDDHYSPDRDRDCEAADRQPYHRS-------------------------RSTEQRPLL 1037
Query: 1209 GKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADTSFSSRRG 1268
+ RSRS+E + SM L+ G SAPPSP L+R H + Q+ P+ T + RRG
Sbjct: 1038 ERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRG 1097
Query: 1269 RQLPQVP 1275
RQLPQ+P
Sbjct: 1098 RQLPQLP 1104
Score = 57.8 bits (138), Expect = 9e-08
Identities = 132/563 (23%), Positives = 224/563 (39%), Gaps = 91/563 (16%)
Query: 1123 DTSLHSPERERGRWSPSLDRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRK--GTA 1180
D SL + + E R S L RP R S R + +++RS ++TR+ G +
Sbjct: 370 DVSLANADLEDSRIS-MLRMDRPSRQR------SISERRAAMENQRSYSMERTREAQGPS 422
Query: 1181 SDAERVLPTCLSRRGHAAPRATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPP 1240
S A+R + PR + P+ R P R+ +L HHL P
Sbjct: 423 SYAQRT-----TNHSPPTPRRSPLPIDR---PDLRRTD------SLRKQHHL------DP 462
Query: 1241 SPLLTRMHRQRSPTQ----SPPADTSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMK 1296
S + + R++ T S +D S S R P + G + Q SL E
Sbjct: 463 SSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEE----- 517
Query: 1297 MKVHRFKQTTGSGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSS- 1355
T S +++ E S Y D+ S SS++ + ++ S
Sbjct: 518 ----ELASTPEYTSCDDVEIESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSK 573
Query: 1356 -ASRLSSTSFMSEQSER---PRGRISSFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHN 1411
RL ++++ + PR + K+ G +M SGR T V
Sbjct: 574 DGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVK--------- 624
Query: 1412 DGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTE 1471
GS +DT VG + G + ++ R + E + L+S + E
Sbjct: 625 KGSLADT-VGHLRPGDE------------VLEWNGRLLQGATFEEVYNIILESKPEPQVE 671
Query: 1472 TGMAAEMRKMVRQPSRESTDGSINSYSSE---GNLIFPGVRL------GADSQFSDFLDG 1522
++ + + R P +ST + S SS + P + + G FL G
Sbjct: 672 LVVSRPIGDIPRIP--DSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSG 729
Query: 1523 LGPAQLVGRQTLATPAMGDIQIGME-DKKG-QLEVEVIRARSLTQKPGSKSTPAPYVKVY 1580
+Q + R+T TP + +QI + DK G QL V ++ A+ L + + PYVK+Y
Sbjct: 730 QLSSQSLSRRT--TPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRN-PYVKIY 786
Query: 1581 LLENGACIAKKKTRIARKTLDPLYQQSLVFD----ESPQGKVLQVIVWGDYGRMDHKCFM 1636
L + + K++T+ +KTL+P + Q+ ++ + ++L++ +W D R+ +
Sbjct: 787 FLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLW-DQARVREEESE 845
Query: 1637 GVAQILLE-ELDLSSMVIGWYKL 1658
+ +IL+E E L WYKL
Sbjct: 846 FLGEILIELETALLDDEPHWYKL 868
Score = 43.9 bits (102), Expect = 0.001
Identities = 41/136 (30%), Positives = 67/136 (49%), Gaps = 10/136 (7%)
Query: 753 DKVGHQLIVNVLQATDLPARVDGRPRN-PYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQ 811
DK G QL V +++A L + + PYVK+Y L + +K++TK +K LEP + Q
Sbjct: 1205 DKKG-QLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQ 1263
Query: 812 TFVYSHVHRRDFRERMLEITVW-DQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTH 870
+ + ++L+I VW D R+ + + +IL++ E L + W+KL
Sbjct: 1264 LLSF----EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLD-ELELSNMVIGWFKL--F 1316
Query: 871 DESSLPLPQPSPFMPR 886
SSL P +P R
Sbjct: 1317 PPSSLVDPTLAPLTRR 1332
Score = 32.3 bits (72), Expect = 4.0
Identities = 32/114 (28%), Positives = 47/114 (41%), Gaps = 23/114 (20%)
Query: 1103 SELQPFLDRARSASTNCLRPDTSL--HSPERERGRW---SPSLDRRRPPSPRIQIQHAS- 1156
+E +P L+R + S + RPDT+L P GR SP+L R P + +Q +S
Sbjct: 1031 TEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSST 1090
Query: 1157 PENDRHSR-----------------KSERSSIQKQTRKGTASDAERVLPTCLSR 1193
P R R K RS++Q+ T G A + + SR
Sbjct: 1091 PVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASR 1144
>gi|154354981 regulating synaptic membrane exocytosis 2 isoform b
[Homo sapiens]
Length = 1163
Score = 938 bits (2424), Expect = 0.0
Identities = 514/923 (55%), Positives = 632/923 (68%), Gaps = 93/923 (10%)
Query: 306 EERERKERRESRRLEKGRSQDY---PDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLA 362
E+ + R+S R S++Y + E RDE E+QR+EE+YQ+RYRSDPNLA
Sbjct: 94 EDSDHLSYRDSNRRSHRHSKEYIVDDEDVESRDE-----YERQRREEEYQSRYRSDPNLA 148
Query: 363 RYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAG----AALPEGKAGKRAPAAAR 418
RYPVKP P E+QMR+HA VSRARHERRHSDV+L + + L + ++ + R
Sbjct: 149 RYPVKPQPYEEQMRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISER 208
Query: 419 ASPPDSPRAYSAERTAETRAPG--AKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRL 476
+ ++ R+YS ERT E + P A++ TNHSPP PR P+P + P+L+ + LRKQ L
Sbjct: 209 RAAMENQRSYSMERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHL 268
Query: 477 DPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEE 536
DPSSAV RK KREK+ETMLRNDSLSSDQSESVRP PPKPH+SK+GGK RQ+S+SSSEEE
Sbjct: 269 DPSSAV--RKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEE 326
Query: 537 GVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRL 596
STPEYTSC+DVE+ESESVSEKGD+DY WLD +WHS E SP+S HPVTWQPSK+GDRL
Sbjct: 327 LASTPEYTSCDDVEIESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRL 386
Query: 597 IGRVILNKRT---TMPKDSGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAG 653
IGR++LNKR ++P+DSGA+LGLKVVGGKMT+ GRL AFITKVKKGSLAD VGHLR G
Sbjct: 387 IGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPG 446
Query: 654 DEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSS 713
DEVLEWNG+ L GAT EEVYNIILESK EPQVE++VSRPIGDIPRIP+S+H LESSSSS
Sbjct: 447 DEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSS 506
Query: 714 FESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARV 773
FESQKM+RPSISV SP SPG L+D PQ L GQLS+KLW+DKVGHQLIV +L A DLP+R
Sbjct: 507 FESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSRE 566
Query: 774 DGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVW 833
DGRPRNPYVK+YFLPDRSDK+KRRTKTVKK LEPKWNQTF+YS VHRR+FRERMLEIT+W
Sbjct: 567 DGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLW 626
Query: 834 DQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGES 893
DQ RV+EEESEFLGEILIELETALLDDEPHWYKLQTHD SSLPLP PSP+MPRR +HGES
Sbjct: 627 DQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGES 686
Query: 894 SSKKLQRSQRISDSDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRS 953
+++LQRS+RISDS++SDY+ DDGIGVV YR R+ +S+TL+VPEQ +++H S S
Sbjct: 687 PTRRLQRSKRISDSEVSDYDCDDGIGVVS--DYRHDGRDLQSSTLSVPEQVMSSNHCSPS 744
Query: 954 VSPHRGNDQGKPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYL 1013
SPHR + G+ RS P+VP +S + R +R+ T H++ HR +D Y
Sbjct: 745 GSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRV--MDDHYS 802
Query: 1014 SEQDSELLMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTK 1073
++DS L LPR++ ++ + H+ H
Sbjct: 803 PDRDSHFLTLPRSRYSQT----------IDHH-------------------------HRD 827
Query: 1074 TKSVTRQDISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSL--HSPER 1131
+ D +H + +E +P L+R + S + RPDT+L P
Sbjct: 828 GRDCEAADRQPYHRSRS------------TEQRPLLERTTTRSRSTERPDTNLMRSMPSL 875
Query: 1132 ERGRW---SPSLDRRRPPSPRIQIQHAS-PENDRHSR-----------------KSERSS 1170
GR SP+L R P + +Q +S P R R K RS+
Sbjct: 876 MTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRST 935
Query: 1171 IQKQTRKGTASDAERVLPTCLSR 1193
+Q+ T G A + + SR
Sbjct: 936 VQRSTETGLAVEMRNWMTRQASR 958
Score = 404 bits (1038), Expect = e-112
Identities = 250/494 (50%), Positives = 296/494 (59%), Gaps = 59/494 (11%)
Query: 1210 KHPARSRSSEHSSI-RTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADTSFSSRRG 1268
+H R S S+ + S +H P GS ++ R R SP+ PP SR
Sbjct: 718 RHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRT-RSWSPSVPPP-----QSRNV 771
Query: 1269 RQ-LPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNIHKD 1327
Q L +G S + R R L R +YS+
Sbjct: 772 EQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDR------DSHFLTLPRSRYSQ------ 819
Query: 1328 QYRSCDNVSAKSSDSDVSDVSAISRTSSASR---LSSTSFMSEQSERPRGRISSFTPKMQ 1384
+ D+ D + +D R+ S + L T+ S +ERP + P +
Sbjct: 820 ---TIDHHHRDGRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLM 876
Query: 1385 GRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSR 1444
R ++ +S +G + T S S T V R
Sbjct: 877 TGRSAPPSPALSRSHPRTGSVQT------SPSSTPVA---------------------GR 909
Query: 1445 RSRSTSQLS-----QTESGHKKLKSTIQRSTETGMAAEMRK-MVRQPSRESTDGSINSYS 1498
R R QL ++G KKL+ST+QRSTETG+A EMR M RQ SRESTDGS+NSYS
Sbjct: 910 RGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYS 969
Query: 1499 SEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVI 1558
SEGNLIFPGVRL +DSQFSDFLDGLGPAQLVGRQTLATPAMGDIQ+GM DKKGQLEVE+I
Sbjct: 970 SEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEII 1029
Query: 1559 RARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKV 1618
RAR L KPGSK+ PAPYVKVYLL+NG CIAKKKT++ARKTL+PLYQQ L F+ESPQGKV
Sbjct: 1030 RARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKV 1089
Query: 1619 LQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQ 1678
LQ+IVWGDYGRMDHK FMGVAQILL+EL+LS+MVIGW+KLFPPSSLVDPTL PLTRRASQ
Sbjct: 1090 LQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQ 1149
Query: 1679 SSLESSTGPPCIRS 1692
SSLESSTGP RS
Sbjct: 1150 SSLESSTGPSYSRS 1163
Score = 73.2 bits (178), Expect = 2e-12
Identities = 46/131 (35%), Positives = 65/131 (49%), Gaps = 11/131 (8%)
Query: 1149 RIQIQHASPENDRHSRKSERS----SIQKQTRKGTASDAERVLPTCLSRRGHAAPRATDQ 1204
R+ H SP+ D H RS +I R G +A R+ + R+T+Q
Sbjct: 795 RVMDDHYSPDRDSHFLTLPRSRYSQTIDHHHRDGRDCEAA-------DRQPYHRSRSTEQ 847
Query: 1205 PVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADTSFS 1264
+ + RSRS+E + SM L+ G SAPPSP L+R H + Q+ P+ T +
Sbjct: 848 RPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVA 907
Query: 1265 SRRGRQLPQVP 1275
RRGRQLPQ+P
Sbjct: 908 GRRGRQLPQLP 918
Score = 48.9 bits (115), Expect = 4e-05
Identities = 126/554 (22%), Positives = 216/554 (38%), Gaps = 89/554 (16%)
Query: 1123 DTSLHSPERERGRWSPSLDRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRK--GTA 1180
D SL + + E R S L RP R S R + +++RS ++TR+ G +
Sbjct: 178 DVSLANADLEDSRIS-MLRMDRPSRQR------SISERRAAMENQRSYSMERTREAQGPS 230
Query: 1181 SDAERVLPTCLSRRGHAAPRATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPP 1240
S A+R + PR + P+ R P R+ +L HHL P
Sbjct: 231 SYAQRT-----TNHSPPTPRRSPLPIDR---PDLRRTD------SLRKQHHL------DP 270
Query: 1241 SPLLTRMHRQRSPTQ----SPPADTSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMK 1296
S + + R++ T S +D S S R P + G + Q SL E
Sbjct: 271 SSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEE----- 325
Query: 1297 MKVHRFKQTTGSGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSS- 1355
T S +++ E S Y D+ S SS++ + ++ S
Sbjct: 326 ----ELASTPEYTSCDDVEIESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSK 381
Query: 1356 -ASRLSSTSFMSEQSER---PRGRISSFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHN 1411
RL ++++ + PR + K+ G +M SGR T V
Sbjct: 382 DGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVK--------- 432
Query: 1412 DGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTE 1471
GS +DT VG + G + ++ R + E + L+S + E
Sbjct: 433 KGSLADT-VGHLRPGDE------------VLEWNGRLLQGATFEEVYNIILESKPEPQVE 479
Query: 1472 TGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGR 1531
++ + + R P +ST + S SS F ++ D + P L
Sbjct: 480 LVVSRPIGDIPRIP--DSTHAQLESSSSS----FESQKM--DRPSISVTSPMSPGML--- 528
Query: 1532 QTLATPAMGDIQIGME-DKKG-QLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIA 1589
+ + G + I + DK G QL V ++ A+ L + + PYVK+Y L + +
Sbjct: 529 RDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRN-PYVKIYFLPDRSDKN 587
Query: 1590 KKKTRIARKTLDPLYQQSLVFD----ESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLE- 1644
K++T+ +KTL+P + Q+ ++ + ++L++ +W D R+ + + +IL+E
Sbjct: 588 KRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLW-DQARVREEESEFLGEILIEL 646
Query: 1645 ELDLSSMVIGWYKL 1658
E L WYKL
Sbjct: 647 ETALLDDEPHWYKL 660
Score = 43.9 bits (102), Expect = 0.001
Identities = 41/136 (30%), Positives = 67/136 (49%), Gaps = 10/136 (7%)
Query: 753 DKVGHQLIVNVLQATDLPARVDGRPRN-PYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQ 811
DK G QL V +++A L + + PYVK+Y L + +K++TK +K LEP + Q
Sbjct: 1019 DKKG-QLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQ 1077
Query: 812 TFVYSHVHRRDFRERMLEITVW-DQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTH 870
+ + ++L+I VW D R+ + + +IL++ E L + W+KL
Sbjct: 1078 LLSF----EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLD-ELELSNMVIGWFKL--F 1130
Query: 871 DESSLPLPQPSPFMPR 886
SSL P +P R
Sbjct: 1131 PPSSLVDPTLAPLTRR 1146
>gi|48476344 regulating synaptic membrane exocytosis 3 [Homo sapiens]
Length = 308
Score = 387 bits (995), Expect = e-107
Identities = 202/302 (66%), Positives = 237/302 (78%), Gaps = 10/302 (3%)
Query: 1391 SGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIV--SRRSRS 1448
+ R++++S+S+SGE+ + G T KKRRSSL AK+VAIV ++ S+S
Sbjct: 13 ASRNVVRSSSISGEICGSQQAGGGAGTTTA-------KKRRSSLGAKMVAIVGLTQWSKS 65
Query: 1449 TSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMV-RQPSRESTDGSINSYSSEGNLIFPG 1507
T QL Q E KKL+S I+RSTETG+A EMR V RQ SRESTDGS NS SS+G IFP
Sbjct: 66 TLQLPQPEGATKKLRSNIRRSTETGIAVEMRSRVTRQGSRESTDGSTNSNSSDGTFIFPT 125
Query: 1508 VRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKP 1567
RLGA+SQFSDFLDGLGPAQ+VGRQTLATP MGD+ I + D+ GQLEVEVI AR LT KP
Sbjct: 126 TRLGAESQFSDFLDGLGPAQIVGRQTLATPPMGDVHIAIMDRSGQLEVEVIEARGLTPKP 185
Query: 1568 GSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDY 1627
GSKS PA Y+KVYLLENGAC+AKKKT++ +KT DPLYQQ+L+FDE PQGKVLQVIVWGDY
Sbjct: 186 GSKSLPATYIKVYLLENGACLAKKKTKMTKKTCDPLYQQALLFDEGPQGKVLQVIVWGDY 245
Query: 1628 GRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGP 1687
GRMDHKCFMG+AQI+L+ELDLS+ V GWYKLFP SS+ D TL LTRR SQSSLES+T P
Sbjct: 246 GRMDHKCFMGMAQIMLDELDLSAAVTGWYKLFPTSSVADSTLGSLTRRLSQSSLESATSP 305
Query: 1688 PC 1689
C
Sbjct: 306 SC 307
Score = 38.1 bits (87), Expect = 0.073
Identities = 29/112 (25%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 758 QLIVNVLQATDLPARVDGRPRNP-YVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYS 816
QL V V++A L + + Y+K+Y L + + +K++TK KK +P + Q ++
Sbjct: 170 QLEVEVIEARGLTPKPGSKSLPATYIKVYLLENGACLAKKKTKMTKKTCDPLYQQALLFD 229
Query: 817 HVHRRDFRERMLEITVW-DQPRVQEEESEFLGEILIELETALLDDEPHWYKL 867
+ ++L++ VW D R+ + + +I+++ E L WYKL
Sbjct: 230 ----EGPQGKVLQVIVWGDYGRMDHKCFMGMAQIMLD-ELDLSAAVTGWYKL 276
>gi|33667061 regulating synaptic membrane exocytosis 4 [Homo sapiens]
Length = 269
Score = 315 bits (807), Expect = 2e-85
Identities = 159/258 (61%), Positives = 198/258 (76%), Gaps = 1/258 (0%)
Query: 1431 RSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEM-RKMVRQPSRES 1489
R SLSA A+ S + ++LK IQRSTETG+A EM + +RQ S ES
Sbjct: 7 RLSLSASFEALAIYFPCMNSFDDEDAGDSRRLKGAIQRSTETGLAVEMPSRTLRQASHES 66
Query: 1490 TDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDK 1549
+ S+NSY SEGNL + GV L +D+QFSDFL +GPAQ VGRQTLAT MGD++IG++++
Sbjct: 67 IEDSMNSYGSEGNLNYGGVCLASDAQFSDFLGSMGPAQFVGRQTLATTPMGDVEIGLQER 126
Query: 1550 KGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLV 1609
GQLEV++I+AR LT KPGSK+ PA Y+K YLLENG CIAKKKT++ARK+LDPLY Q L+
Sbjct: 127 NGQLEVDIIQARGLTAKPGSKTLPAAYIKAYLLENGICIAKKKTKVARKSLDPLYNQVLL 186
Query: 1610 FDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTL 1669
F ESPQGKVLQVIVWG+YGRM+ K FMGVA++LLEELDL+++ +GWYKLFP SS+VDP
Sbjct: 187 FPESPQGKVLQVIVWGNYGRMERKQFMGVARVLLEELDLTTLAVGWYKLFPTSSMVDPAT 246
Query: 1670 TPLTRRASQSSLESSTGP 1687
PL R+ASQ SLES+ GP
Sbjct: 247 GPLLRQASQLSLESTVGP 264
Score = 44.3 bits (103), Expect = 0.001
Identities = 35/129 (27%), Positives = 65/129 (50%), Gaps = 9/129 (6%)
Query: 758 QLIVNVLQATDLPARVDGRPRNP-YVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYS 816
QL V+++QA L A+ + Y+K Y L + +K++TK +K L+P +NQ ++
Sbjct: 129 QLEVDIIQARGLTAKPGSKTLPAAYIKAYLLENGICIAKKKTKVARKSLDPLYNQVLLFP 188
Query: 817 HVHRRDFRERMLEITVW-DQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSL 875
+ ++L++ VW + R++ ++ + +L+E E L WYKL SS+
Sbjct: 189 ----ESPQGKVLQVIVWGNYGRMERKQFMGVARVLLE-ELDLTTLAVGWYKL--FPTSSM 241
Query: 876 PLPQPSPFM 884
P P +
Sbjct: 242 VDPATGPLL 250
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 141 bits (355), Expect = 6e-33
Identities = 115/366 (31%), Positives = 166/366 (45%), Gaps = 84/366 (22%)
Query: 612 SGALLGLKVVGGKMTD--LGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATN 669
SG LG+++VGGK G +GA+I K+ G A+ G L G +VLEWNG PL T
Sbjct: 4509 SGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEGMQVLEWNGIPLTSKTY 4568
Query: 670 EEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSH---------------PPLESSSSSF 714
EEV +II + E EI V + + S H P ++ +
Sbjct: 4569 EEVQSIISQQSGE--AEICVRLDLNMLSDSENSQHLELHEPPKAVDKAKSPGVDPKQLAA 4626
Query: 715 ESQKMERP------------------------SISVISPTSPGA---------------- 734
E QK+ S SV SP PG+
Sbjct: 4627 ELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGSPSVSKKKHGSSKPTDG 4686
Query: 735 LKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDR---- 790
K + G++ +++ YD +G+ LI+++LQA +L R + +P+VK+Y LP R
Sbjct: 4687 TKVVSHPITGEIQLQINYD-LGN-LIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVM 4744
Query: 791 -----SDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEF 845
S + KRRTK V+K L P+WNQT +Y + +++ LE+TVWD R ++F
Sbjct: 4745 VVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRF--SSNDF 4802
Query: 846 LGEILIEL-ETALLDDEPHWYKLQTHDE-----------SSLPLPQPSPFMPRRHIHGES 893
LGE+LI+L T+ LD+ P WY L+ E SS P+PS R H
Sbjct: 4803 LGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSHGIFPD 4862
Query: 894 SSKKLQ 899
SK +Q
Sbjct: 4863 PSKDMQ 4868
Score = 49.3 bits (116), Expect = 3e-05
Identities = 117/567 (20%), Positives = 212/567 (37%), Gaps = 102/567 (17%)
Query: 62 AKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARR--YQGEHKDDAPTCG-- 117
AKP+A + P A+ Q + + Q Q + A++ QG K P C
Sbjct: 537 AKPSA-QQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTT 595
Query: 118 --ICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKS 175
+ H + A+ + C+ C+T C+ CG + + +V W+C C+ ++ +
Sbjct: 596 ELLLHVPEKANF--NTCTECQTTVCSLCGFN---PNPHLTEVKEWLCLNCQMKRALGGDL 650
Query: 176 GAWFFGSGPQQTSQDGTLSDTATGAGSE------VPREKKARLQERSRSQTPLSTAAASS 229
S PQ + ++ T+ + S P++ A Q+ S++ P
Sbjct: 651 AP--VPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVK 708
Query: 230 QDA--APPSA----PPDR---SKGAEPSQQALGPEQKQAS-SRSRSEPPRERKKTPGLSE 279
Q PSA PP+ SK A P + ++ EQ +A + + + P+ K T L
Sbjct: 709 QPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVS 768
Query: 280 Q----------NGKGALKSERKRVP--KT-SAQPVEGAVEERERKERRESRRLEKGRSQ- 325
+ K ++E K P KT SA+P + E+ +S+ + + S
Sbjct: 769 SSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDS 828
Query: 326 ---DYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPV---------------- 366
+P P +G+ + Q+KEE + + + P P+
Sbjct: 829 KIISHPG-PSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQ 887
Query: 367 -------KPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEG-----KAGKRAP 414
P P+EQ R + + T G G +A
Sbjct: 888 TVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLIS 947
Query: 415 AAARASP-----PDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHG-PVPAE--APELKA 466
A + P P +P + + + G + T +PPAP PV E AP +
Sbjct: 948 TAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEK 1007
Query: 467 QEPLRKQSRLDPSSAVLMRKAKREKVETMLRND-SLSSDQSESVRPS----PPKPHRSKR 521
EP +Q A +++ + EK +++ SL+++ ++V P+ PKP S
Sbjct: 1008 LEPKAEQ-------APTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKP-ESTC 1059
Query: 522 GGKKRQMSVSSSEEEGVSTPEYTSCED 548
K ++++ S + P + +C +
Sbjct: 1060 PLCKTELNIGSKD-----PPNFNTCTE 1081
Score = 39.3 bits (90), Expect = 0.033
Identities = 116/634 (18%), Positives = 221/634 (34%), Gaps = 92/634 (14%)
Query: 57 VVRDMAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAP-- 114
V ++ PAA K AE P ++ K+ E + + +P
Sbjct: 996 VKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKP 1055
Query: 115 --TCGICHKTKFADGCG-----HLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRK 167
TC +C KT+ G + C+ C+ + C CG + ++ W+C C+
Sbjct: 1056 ESTCPLC-KTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLT---EIQEWLCLNCQT 1111
Query: 168 QQEILTKSGAWF----FGSGPQQTSQDGTLSDTA--TGAGSEVPREKKARLQERSRSQTP 221
Q+ I + G SGP+ + ++ T +V KK + ++ ++
Sbjct: 1112 QRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKV 1171
Query: 222 L--STAAASSQDAAPPSAPPDRS----------------KGAEPSQQALGPEQKQASSRS 263
+ S + PP D+ K P ++ L PE+++ S
Sbjct: 1172 ILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEE 1231
Query: 264 RSEPPRERKKTP---GLSEQNGKGALKSERKRVPKTSAQ----PVEGAVEERERKERRES 316
+ E+K TP L + A + ++ + K+ Q +EG V + +E ++
Sbjct: 1232 KKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQP 1291
Query: 317 RRLEKGRSQDYPDTPEKRDEGKA--------------ADEEKQRKEEDYQTRYRSDPNLA 362
+ +G P + K D+ D+ + KE+ + +SD + +
Sbjct: 1292 QTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSS 1351
Query: 363 RYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARASPP 422
+ P P +S + E +L T+ L K + ++ +SP
Sbjct: 1352 QQPKSPQGLSDTGYSSDGISSSLGE----IPSLIPTDEKDILKGLKKDSFSQESSPSSPS 1407
Query: 423 DSPRAYS---------AERTAETRAPGAKQLTNHSPPAPRHG----------PVPAEAPE 463
D + S A A+ ++ Q SP P+ + E
Sbjct: 1408 DLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEE 1467
Query: 464 LKAQEPLRKQS-RLDPSSAVLMRKAKREKVETM----LRNDSLSSDQSESVRPSPPKPHR 518
+K + RK + + D + K +EK E + R + S + S + P P R
Sbjct: 1468 IKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQR 1527
Query: 519 SKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETS 578
+R + SSS+E + + E+ + + + D D + + +
Sbjct: 1528 KRR----TSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLK 1583
Query: 579 PISSHPVTWQPSKEGDRLIGRVILNKRTTMPKDS 612
ISS T KE + G++ K + + S
Sbjct: 1584 EISSS--TESQKKEETKGKGKITAGKHRRLTRKS 1615
Score = 36.6 bits (83), Expect = 0.21
Identities = 63/285 (22%), Positives = 104/285 (36%), Gaps = 41/285 (14%)
Query: 186 QTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAP--PSAPPDRSK 243
+ SQ G A +G P Q+ + P+ + A P P+ PP +
Sbjct: 322 EKSQPGPAKPPAQPSGLTKPLA-----QQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQT 376
Query: 244 GAE-PSQQALGPE---------QKQASSRSRSEPPRERKKTP-GLSEQNGKGALKSERKR 292
G+E PS + GP+ + A ++PP ++ TP L++Q G L+S K
Sbjct: 377 GSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPG---LQSPAKA 433
Query: 293 VPKTSA---QPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQ---R 346
T QP G + ++ + S + Q P P + G A +Q
Sbjct: 434 PGPTKTPVQQPGPGKIPAQQAGPGKTSAQ------QTGPTKPPSQLPGPAKPPPQQPGPA 487
Query: 347 KEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPE 406
K Q P+ KPPP++ + ++ P + G+A P
Sbjct: 488 KPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS-------PQQPGSTKPPSQQPGSAKPS 540
Query: 407 GKAGKRA-PAAARASPPDSPRAYSAERTAETRAPGAKQLTNHSPP 450
+ A P+A +++ P S T +P AKQ + P
Sbjct: 541 AQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLP 585
Score = 34.7 bits (78), Expect = 0.81
Identities = 47/208 (22%), Positives = 79/208 (37%), Gaps = 41/208 (19%)
Query: 197 ATGAGSE----VPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQAL 252
A+GAGS +P +A L + S + A S P KG+ P A
Sbjct: 26 ASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLP--------KGSVPPAAAE 77
Query: 253 GPEQKQASSRSRSEPPRE--------RKKTPGLSEQNGKGALKSERK---RVPKTSAQPV 301
P + S PP++ R PGLS+ +SE+K R P T + +
Sbjct: 78 SPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTIS--L 135
Query: 302 EGAVEERERKERRESRRLEKGRSQ-----------DYPDTPEKRDEGKAADEEKQRKEED 350
+ + + KE +S + S+ + + + + +A+ EE +K++
Sbjct: 136 KESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKV 195
Query: 351 YQTRYRS-----DPNLARYPVKPPPEEQ 373
Q P L + P KP P++Q
Sbjct: 196 VQKEQGKPEGIIKPPLQQQPPKPIPKQQ 223
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 141 bits (355), Expect = 6e-33
Identities = 115/366 (31%), Positives = 166/366 (45%), Gaps = 84/366 (22%)
Query: 612 SGALLGLKVVGGKMTD--LGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATN 669
SG LG+++VGGK G +GA+I K+ G A+ G L G +VLEWNG PL T
Sbjct: 4509 SGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEGMQVLEWNGIPLTSKTY 4568
Query: 670 EEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSH---------------PPLESSSSSF 714
EEV +II + E EI V + + S H P ++ +
Sbjct: 4569 EEVQSIISQQSGE--AEICVRLDLNMLSDSENSQHLELHEPPKAVDKAKSPGVDPKQLAA 4626
Query: 715 ESQKMERP------------------------SISVISPTSPGA---------------- 734
E QK+ S SV SP PG+
Sbjct: 4627 ELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGSPSVSKKKHGSSKPTDG 4686
Query: 735 LKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDR---- 790
K + G++ +++ YD +G+ LI+++LQA +L R + +P+VK+Y LP R
Sbjct: 4687 TKVVSHPITGEIQLQINYD-LGN-LIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVM 4744
Query: 791 -----SDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEF 845
S + KRRTK V+K L P+WNQT +Y + +++ LE+TVWD R ++F
Sbjct: 4745 VVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRF--SSNDF 4802
Query: 846 LGEILIEL-ETALLDDEPHWYKLQTHDE-----------SSLPLPQPSPFMPRRHIHGES 893
LGE+LI+L T+ LD+ P WY L+ E SS P+PS R H
Sbjct: 4803 LGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSHGIFPD 4862
Query: 894 SSKKLQ 899
SK +Q
Sbjct: 4863 PSKDMQ 4868
Score = 77.4 bits (189), Expect = 1e-13
Identities = 99/416 (23%), Positives = 181/416 (43%), Gaps = 46/416 (11%)
Query: 1281 IEQASLVVEERTRQMKMKVH-RFKQTT--GSGSSQELDREQYSKYNIHKDQYRSCDNVSA 1337
++ AS + RT+ ++ ++ + QT S S ++L ++ D++ S D +
Sbjct: 4746 VQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGE 4805
Query: 1338 KSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFTPKMQGRRMGTSGRSIMK 1397
D +S S + T L + + + + S +PK + + G I
Sbjct: 4806 VLID--LSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSHG--IFP 4861
Query: 1398 STSVSGEMYTLEHND---GSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQ 1454
S ++ T+E + GS ++ G + + G R S K + + + ++
Sbjct: 4862 DPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQS---KTSVTQTHLEDAGAAIAA 4918
Query: 1455 TESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNL-------IFPG 1507
E+ ++L+ + T+ V S S+ GS S SEG+ +FP
Sbjct: 4919 AEAAVQQLRI---QPTKPPNHRPAESSVSTGSSGSSFGSGYSVDSEGSSSTAGETNLFPI 4975
Query: 1508 VRLGADSQFSDFLDGLGPAQLVG------RQTLATPAMGDIQIGMEDKKG----QLEVEV 1557
R+G Q +G P + G T MG+I+I ++ + QL VE+
Sbjct: 4976 PRIGKMGQ-----NGQEPVKQPGVGVGLADTEAKTQVMGEIKIALKKEMKTDGEQLIVEI 5030
Query: 1558 IRARSLTQKPGSKS-TPAPYVKVYLLENGAC--IAKKKTRIARKTLDPLYQQSLVFDESP 1614
++ R++T K S P YVK+Y++ + KKKTR+ R +P + ++ F SP
Sbjct: 5031 LQCRNITYKFKSPDHLPDLYVKIYVMNISTQKKVIKKKTRVCRHDREPSFNETFRFSLSP 5090
Query: 1615 QGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLT 1670
G LQ++++ + G+ K +G A I L+++DL ++ W+KL LV PT T
Sbjct: 5091 AGHSLQILLFSNGGKFMKKTLIGEACIWLDKVDLRKRIVNWHKL-----LVSPTQT 5141
Score = 49.3 bits (116), Expect = 3e-05
Identities = 117/567 (20%), Positives = 212/567 (37%), Gaps = 102/567 (17%)
Query: 62 AKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARR--YQGEHKDDAPTCG-- 117
AKP+A + P A+ Q + + Q Q + A++ QG K P C
Sbjct: 537 AKPSA-QQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTT 595
Query: 118 --ICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKS 175
+ H + A+ + C+ C+T C+ CG + + +V W+C C+ ++ +
Sbjct: 596 ELLLHVPEKANF--NTCTECQTTVCSLCGFN---PNPHLTEVKEWLCLNCQMKRALGGDL 650
Query: 176 GAWFFGSGPQQTSQDGTLSDTATGAGSE------VPREKKARLQERSRSQTPLSTAAASS 229
S PQ + ++ T+ + S P++ A Q+ S++ P
Sbjct: 651 AP--VPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVK 708
Query: 230 QDA--APPSA----PPDR---SKGAEPSQQALGPEQKQAS-SRSRSEPPRERKKTPGLSE 279
Q PSA PP+ SK A P + ++ EQ +A + + + P+ K T L
Sbjct: 709 QPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVS 768
Query: 280 Q----------NGKGALKSERKRVP--KT-SAQPVEGAVEERERKERRESRRLEKGRSQ- 325
+ K ++E K P KT SA+P + E+ +S+ + + S
Sbjct: 769 SSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDS 828
Query: 326 ---DYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPV---------------- 366
+P P +G+ + Q+KEE + + + P P+
Sbjct: 829 KIISHPG-PSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQ 887
Query: 367 -------KPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEG-----KAGKRAP 414
P P+EQ R + + T G G +A
Sbjct: 888 TVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLIS 947
Query: 415 AAARASP-----PDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHG-PVPAE--APELKA 466
A + P P +P + + + G + T +PPAP PV E AP +
Sbjct: 948 TAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEK 1007
Query: 467 QEPLRKQSRLDPSSAVLMRKAKREKVETMLRND-SLSSDQSESVRPS----PPKPHRSKR 521
EP +Q A +++ + EK +++ SL+++ ++V P+ PKP S
Sbjct: 1008 LEPKAEQ-------APTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKP-ESTC 1059
Query: 522 GGKKRQMSVSSSEEEGVSTPEYTSCED 548
K ++++ S + P + +C +
Sbjct: 1060 PLCKTELNIGSKD-----PPNFNTCTE 1081
Score = 39.3 bits (90), Expect = 0.033
Identities = 116/634 (18%), Positives = 221/634 (34%), Gaps = 92/634 (14%)
Query: 57 VVRDMAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAP-- 114
V ++ PAA K AE P ++ K+ E + + +P
Sbjct: 996 VKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKP 1055
Query: 115 --TCGICHKTKFADGCG-----HLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRK 167
TC +C KT+ G + C+ C+ + C CG + ++ W+C C+
Sbjct: 1056 ESTCPLC-KTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLT---EIQEWLCLNCQT 1111
Query: 168 QQEILTKSGAWF----FGSGPQQTSQDGTLSDTA--TGAGSEVPREKKARLQERSRSQTP 221
Q+ I + G SGP+ + ++ T +V KK + ++ ++
Sbjct: 1112 QRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKV 1171
Query: 222 L--STAAASSQDAAPPSAPPDRS----------------KGAEPSQQALGPEQKQASSRS 263
+ S + PP D+ K P ++ L PE+++ S
Sbjct: 1172 ILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEE 1231
Query: 264 RSEPPRERKKTP---GLSEQNGKGALKSERKRVPKTSAQ----PVEGAVEERERKERRES 316
+ E+K TP L + A + ++ + K+ Q +EG V + +E ++
Sbjct: 1232 KKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQP 1291
Query: 317 RRLEKGRSQDYPDTPEKRDEGKA--------------ADEEKQRKEEDYQTRYRSDPNLA 362
+ +G P + K D+ D+ + KE+ + +SD + +
Sbjct: 1292 QTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSS 1351
Query: 363 RYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARASPP 422
+ P P +S + E +L T+ L K + ++ +SP
Sbjct: 1352 QQPKSPQGLSDTGYSSDGISSSLGE----IPSLIPTDEKDILKGLKKDSFSQESSPSSPS 1407
Query: 423 DSPRAYS---------AERTAETRAPGAKQLTNHSPPAPRHG----------PVPAEAPE 463
D + S A A+ ++ Q SP P+ + E
Sbjct: 1408 DLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEE 1467
Query: 464 LKAQEPLRKQS-RLDPSSAVLMRKAKREKVETM----LRNDSLSSDQSESVRPSPPKPHR 518
+K + RK + + D + K +EK E + R + S + S + P P R
Sbjct: 1468 IKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQR 1527
Query: 519 SKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETS 578
+R + SSS+E + + E+ + + + D D + + +
Sbjct: 1528 KRR----TSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLK 1583
Query: 579 PISSHPVTWQPSKEGDRLIGRVILNKRTTMPKDS 612
ISS T KE + G++ K + + S
Sbjct: 1584 EISSS--TESQKKEETKGKGKITAGKHRRLTRKS 1615
Score = 36.6 bits (83), Expect = 0.21
Identities = 63/285 (22%), Positives = 104/285 (36%), Gaps = 41/285 (14%)
Query: 186 QTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAP--PSAPPDRSK 243
+ SQ G A +G P Q+ + P+ + A P P+ PP +
Sbjct: 322 EKSQPGPAKPPAQPSGLTKPLA-----QQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQT 376
Query: 244 GAE-PSQQALGPE---------QKQASSRSRSEPPRERKKTP-GLSEQNGKGALKSERKR 292
G+E PS + GP+ + A ++PP ++ TP L++Q G L+S K
Sbjct: 377 GSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPG---LQSPAKA 433
Query: 293 VPKTSA---QPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQ---R 346
T QP G + ++ + S + Q P P + G A +Q
Sbjct: 434 PGPTKTPVQQPGPGKIPAQQAGPGKTSAQ------QTGPTKPPSQLPGPAKPPPQQPGPA 487
Query: 347 KEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPE 406
K Q P+ KPPP++ + ++ P + G+A P
Sbjct: 488 KPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS-------PQQPGSTKPPSQQPGSAKPS 540
Query: 407 GKAGKRA-PAAARASPPDSPRAYSAERTAETRAPGAKQLTNHSPP 450
+ A P+A +++ P S T +P AKQ + P
Sbjct: 541 AQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLP 585
Score = 35.8 bits (81), Expect = 0.36
Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 4/65 (6%)
Query: 756 GHQLIVNVLQATDLPARVDGRPRNP--YVKMYFLPDRSDKS--KRRTKTVKKILEPKWNQ 811
G QLIV +LQ ++ + P YVK+Y + + K K++T+ + EP +N+
Sbjct: 5023 GEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVMNISTQKKVIKKKTRVCRHDREPSFNE 5082
Query: 812 TFVYS 816
TF +S
Sbjct: 5083 TFRFS 5087
Score = 34.7 bits (78), Expect = 0.81
Identities = 47/208 (22%), Positives = 79/208 (37%), Gaps = 41/208 (19%)
Query: 197 ATGAGSE----VPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQAL 252
A+GAGS +P +A L + S + A S P KG+ P A
Sbjct: 26 ASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLP--------KGSVPPAAAE 77
Query: 253 GPEQKQASSRSRSEPPRE--------RKKTPGLSEQNGKGALKSERK---RVPKTSAQPV 301
P + S PP++ R PGLS+ +SE+K R P T + +
Sbjct: 78 SPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTIS--L 135
Query: 302 EGAVEERERKERRESRRLEKGRSQ-----------DYPDTPEKRDEGKAADEEKQRKEED 350
+ + + KE +S + S+ + + + + +A+ EE +K++
Sbjct: 136 KESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKV 195
Query: 351 YQTRYRS-----DPNLARYPVKPPPEEQ 373
Q P L + P KP P++Q
Sbjct: 196 VQKEQGKPEGIIKPPLQQQPPKPIPKQQ 223
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 85.9 bits (211), Expect = 3e-16
Identities = 91/358 (25%), Positives = 143/358 (39%), Gaps = 41/358 (11%)
Query: 205 PREKKAR--LQERSRSQTPLS---TAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQA 259
PR +++R ++ R RS LS ++++SS+ +PP PP R+ + L P
Sbjct: 336 PRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPP 395
Query: 260 SSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQP--VEGAVEERERKERRES- 316
R R PP TP ++ +S R R + S P G V + + E+RES
Sbjct: 396 RRRHRPSPP----ATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESP 451
Query: 317 ------RRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPP 370
R++E S++ +K + AAD +QR++ Q + S + +
Sbjct: 452 SPAPKPRKVELSESEE-----DKGGKMAAADSVQQRRQYRRQNQQSSSDSGSS---SSSE 503
Query: 371 EEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARASPPDSPRAYSA 430
+E+ R H + RRHS + + + P + + +P R P P +
Sbjct: 504 DERPKRSHVKNGEVGRRRRHSP-----SRSASPSPRKRQKETSPRGRRRRSPSPPP--TR 556
Query: 431 ERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRK----QSRLDPSSAVLMRK 486
R + + AP ++ +PP R P P P ++ P R Q R PS R
Sbjct: 557 RRRSPSPAPPPRRRRTPTPPPRRRTPSP--PPRRRSPSPRRYSPPIQRRYSPSPPPKRRT 614
Query: 487 AKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYT 544
A R S S V SPP RS K+R S+SS +G S T
Sbjct: 615 ASPPPPPK--RRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRST 670
Score = 68.2 bits (165), Expect = 7e-11
Identities = 74/337 (21%), Positives = 130/337 (38%), Gaps = 39/337 (11%)
Query: 202 SEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASS 261
S PR +K+R R +P+ S +P RS P ++ PE + S
Sbjct: 169 SRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSV 228
Query: 262 RSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQPVEGAVEERER-KERRESRRLE 320
+ + +E T + + + ++ P+ +++ + + R R + R +SR
Sbjct: 229 KVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRT 288
Query: 321 KGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHAR 380
+ RS + P +R ++ +R+ R R P P + PP + R +
Sbjct: 289 RSRSPSH-TRPRRRHRSRSRSYSPRRRP---SPRRRPSPRRRTPPRRMPPPPRHRRSRSP 344
Query: 381 VSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPG 440
V R RR S +L + + ++ ++ + P +SPP R S P
Sbjct: 345 VRR----RRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLS---------PS 391
Query: 441 AKQLTNHSPPAPRHGPVPAEAPELKAQ-EPLRKQSRLDPSSAVLMRKAKREKVETMLRND 499
A SPP RH P P P K + P +QS S V + + T +
Sbjct: 392 A------SPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHK-- 443
Query: 500 SLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEE 536
+++ ES P+P K R++ +S SEE+
Sbjct: 444 --GTEKRESPSPAP----------KPRKVELSESEED 468
Score = 62.0 bits (149), Expect = 5e-09
Identities = 87/391 (22%), Positives = 145/391 (37%), Gaps = 72/391 (18%)
Query: 188 SQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDA---APPSAPPDRSKG 244
S G+ S +++ P++ R R LS +A+ + +PP+ PP +++
Sbjct: 354 SLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRH 413
Query: 245 AEPSQQA---------------LGPEQKQASSRSRSEP---PRERKKTPGLSEQNGKGAL 286
+ QQ+ G K + R P P+ RK SE++ G +
Sbjct: 414 SPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKM 473
Query: 287 ---------KSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGR------SQDYPDTP 331
+ R++ ++S+ + E ER +R + E GR S+ +P
Sbjct: 474 AAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSP 533
Query: 332 EKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHS 391
KR + + ++R TR R P+ A PPP RR +
Sbjct: 534 RKRQKETSPRGRRRRSPSPPPTRRRRSPSPA-----PPP----------------RRRRT 572
Query: 392 DVALPRTEAGAALPEGKAGKRAPAAARASPP----DSPRAYSAERTAETRAPGAKQLTNH 447
PR + P +R+P+ R SPP SP RTA P ++ +
Sbjct: 573 PTPPPRRRTPSPPPR----RRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPS 628
Query: 448 SPPAPR--HGPVPAE--APELKAQEP-LRKQSRLDPSSAVLMRKAKREKVETMLRNDSLS 502
PP R H P P + +P K + P L + R S + R+A+ + R+
Sbjct: 629 PPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNK--RHSPSP 686
Query: 503 SDQSESVRPSPPKPHRSKRGGKKRQMSVSSS 533
++ SPP R +R+ S S S
Sbjct: 687 RPRAPQTSSSPPPVRRGASSSPQRRQSPSPS 717
Score = 57.8 bits (138), Expect = 9e-08
Identities = 82/362 (22%), Positives = 135/362 (37%), Gaps = 71/362 (19%)
Query: 194 SDTATGAGSEVPREKKARLQE----RSRSQTPLSTAAASSQDAAPPSAPPDR---SKGAE 246
SD+ + + SE R K++ ++ R R +P +A+ S + ++P R S
Sbjct: 494 SDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPP 553
Query: 247 PSQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQPVEGAVE 306
P+++ P R R+ P R++TP + R P+ + P++
Sbjct: 554 PTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRR--------RSPSPRRYSPPIQ---- 601
Query: 307 ERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPV 366
RR S R P P KR + K+R + RS P R
Sbjct: 602 ------RRYSPSPPPKRRTASPPPPPKR-RASPSPPPKRRVSHSPPPKQRSSPVTKR--- 651
Query: 367 KPPPEEQQMRMHARVSRARHE-------RRHSDVALPRT-EAGAALPEGKAGKRAPAAAR 418
+ P + R + SR+ E +RHS PR + ++ P + G + R
Sbjct: 652 RSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRR 711
Query: 419 ASPPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRH------------GPVPAEAPELKA 466
SP S R +R P K++ + P+P+ P PA
Sbjct: 712 QSPSPSTRPIRRV----SRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAP 767
Query: 467 QEPLRKQS-RLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKK 525
P++ QS + S AV ++KAK S + PSPP+ + GGKK
Sbjct: 768 PSPVQSQSPSTNWSPAVPVKKAK-----------------SPTPSPSPPRNSDQEGGGKK 810
Query: 526 RQ 527
++
Sbjct: 811 KK 812
Score = 53.1 bits (126), Expect = 2e-06
Identities = 70/317 (22%), Positives = 121/317 (38%), Gaps = 43/317 (13%)
Query: 226 AASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGA 285
+A A PSA + K E +Q ++K AS + + E +R K S + +
Sbjct: 111 SAQENIAGIPSAFLELKK--EEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRER 168
Query: 286 LKSERKR-----VPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAA 340
+S R+R P+ + PV ER+R R R K RS PEK+++
Sbjct: 169 SRSPRRRKSRSPSPRRRSSPVR---RERKRSHSRSPRHRTKSRSPS--PAPEKKEKTPEL 223
Query: 341 DEEKQRKEEDYQTRYRSDPNLARYPVK---PPPEEQQMRMHARVSRARHERRHSDVALPR 397
E + +E S ++ + P P P+E +++ + + + R
Sbjct: 224 PEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTR-------- 275
Query: 398 TEAGAALPEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPV 457
P ++ ++ + R+ P R R+ ++ + P+PR P
Sbjct: 276 -------PRSRSRSKSRSRTRSRSPSHTRPRRRHRSR------SRSYSPRRRPSPRRRPS 322
Query: 458 P-AEAPELKAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKP 516
P P + P R + P +R+ +R + S SS +S S PPK
Sbjct: 323 PRRRTPPRRMPPPPRHRRSRSP-----VRRRRRSSASLSGSSSSSSSSRSRSPPKKPPK- 376
Query: 517 HRSKRGGKKRQMSVSSS 533
S K R++S S+S
Sbjct: 377 RTSSPPRKTRRLSPSAS 393
Score = 47.0 bits (110), Expect = 2e-04
Identities = 138/573 (24%), Positives = 198/573 (34%), Gaps = 125/573 (21%)
Query: 869 THDESSLPLPQPSPFMPRRHIHGESSSKKLQRSQRISDSDISDYEVDDGIGVVPPVGYRS 928
T L +P+P P + E +SKK + ++ S RS
Sbjct: 239 TSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRS----------------RS 282
Query: 929 SARE---SKSTTLTVPEQQRTTHHRSRSVSPHRGNDQGKPRSRLPNVPLQRSLDEIHPTR 985
+R S+S + T P ++ + RSRS SP R +P R P +R+ P R
Sbjct: 283 KSRSRTRSRSPSHTRPRRRHRS--RSRSYSPRR-----RPSPRRRPSPRRRT-----PPR 330
Query: 986 RSRSPTRHHDASRSPVDHRTRD---VDSQYLSEQDSELLMLPRAKRGRSAECLHTTRHLV 1042
R P RH SRSPV R R + S S P+ R++ TR L
Sbjct: 331 RMPPPPRHR-RSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLS 389
Query: 1043 -------RHYKTLPPKMPL---------LQSSSHWNIYSSILPAHTKTKSVTRQDISLHH 1086
R ++ PP P QS+ S+ P T K VT+ +
Sbjct: 390 PSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGK-VTKHKGTEKR 448
Query: 1087 ECFNSTVLRFTDEILVSE-----------------------LQPFLDRARSASTNCLRPD 1123
E + E+ SE Q D S+S+ RP
Sbjct: 449 ESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPK 508
Query: 1124 TSLHSPERERGR---WSPSLDRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTA 1180
S H E GR SPS R PSPR + + SP R S + ++++
Sbjct: 509 RS-HVKNGEVGRRRRHSPS--RSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAP 565
Query: 1181 SDAERVLPTCLSRRGHAAPRATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPP 1240
R PT R R T P R + P+ R S R S S PP
Sbjct: 566 PPRRRRTPTPPPR------RRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPP 619
Query: 1241 SPLLTRMHRQRSPTQSPPADTSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVH 1300
P +R + SPP RR P RS S V + R+ + K H
Sbjct: 620 PP-------KRRASPSPP-----PKRRVSHSPPPKQRS------SPVTKRRSPSLSSK-H 660
Query: 1301 RFKQTTGSGSSQELDREQYSKYNIHKDQYRSCDNVSA---------------KSSDSDVS 1345
R K ++ S S++E Q +K + + R+ S+ +S
Sbjct: 661 R-KGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTR 719
Query: 1346 DVSAISRTSSASRLSSTSFMSEQSERPRGRISS 1378
+ +SRT ++ + S QS R R+SS
Sbjct: 720 PIRRVSRTPEPKKIKKAASPSPQSVR---RVSS 749
Score = 40.4 bits (93), Expect = 0.015
Identities = 109/530 (20%), Positives = 175/530 (33%), Gaps = 75/530 (14%)
Query: 969 LPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSELLMLPRAKR 1028
+P+ L+ +EI +R + + D RD + + S + E PR ++
Sbjct: 119 IPSAFLELKKEEIK--QRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRK 176
Query: 1029 GRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTKTK--------SVTRQ 1080
RS + + R K + P ++ S S PA K + SV +
Sbjct: 177 SRSPSPRRRSSPVRRERKRSHSRSPRHRTKSR-----SPSPAPEKKEKTPELPEPSVKVK 231
Query: 1081 DISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSLHSPERERGRWSPSL 1140
+ S+ S +L+ + E + S N + + R R R S S
Sbjct: 232 EPSVQEATSTSDILKVPKPEPIPE-----PKEPSPEKNSKKEKEKEKTRPRSRSR-SKSR 285
Query: 1141 DRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPR 1200
R R SP H P SR S ++ + + S R P RR PR
Sbjct: 286 SRTRSRSP----SHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPP----RRMPPPPR 337
Query: 1201 ATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPAD 1260
R + P R R +S+ G S+ S R RSP + PP
Sbjct: 338 HR-----RSRSPVRRRRRSSASLS----------GSSSSSSS-----SRSRSPPKKPPKR 377
Query: 1261 TSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYS 1320
TS R+ R+L S R + +T S + Q+ +R + S
Sbjct: 378 TSSPPRKTRRL-----------SPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKS 426
Query: 1321 KYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFT 1380
+ ++ ++S R S + +SE +G +
Sbjct: 427 RVSVS----------PGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAA 476
Query: 1381 PKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVA 1440
+Q RR R +S+S SG + E +S G V G++RR S S
Sbjct: 477 DSVQQRRQ--YRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEV---GRRRRHSPSRSASP 531
Query: 1441 IVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSREST 1490
+R + TS + + +RS R+ P R T
Sbjct: 532 SPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRT 581
Score = 35.4 bits (80), Expect = 0.47
Identities = 69/288 (23%), Positives = 102/288 (35%), Gaps = 39/288 (13%)
Query: 940 VPEQQRTTHHRSRSVSPHRGNDQGKPRSRLPNVPL------QRSLDEIHPTRRSRSPTRH 993
V ++R + RS S SP + + PR R P +RS P RR R+PT
Sbjct: 517 VGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPP 576
Query: 994 -HDASRSPVDHRTRDVDSQYLSEQDSELLMLPRAKRGRSAECLHTTRHLVRHYKTLPPKM 1052
+ SP R +Y P KR ++ R R + PPK
Sbjct: 577 PRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKR---RASPSPPPKR 633
Query: 1053 PLLQSSSHWNIYSSILPAHTKTKSVTRQ---DISLHHECFNSTVLRFTDEILVSELQPFL 1109
+ S P ++ VT++ +S H S+ R T E P
Sbjct: 634 RVSHSP----------PPKQRSSPVTKRRSPSLSSKHRK-GSSPSRSTREAR----SPQP 678
Query: 1110 DRARSASTNCLRPDTSLHSPERERGRWSPSLDRRRPPSPRIQIQHASPENDRHSRKSERS 1169
++ S S P TS P RG S S RR+ PSP + R R+ R+
Sbjct: 679 NKRHSPSPRPRAPQTSSSPPPVRRGA-SSSPQRRQSPSP----------STRPIRRVSRT 727
Query: 1170 SIQKQTRKGTASDAERVLPTCLSRRGHAAPRATDQPVIRGKHPARSRS 1217
K+ +K + + V SR +P + P +S+S
Sbjct: 728 PEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQS 775
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 75.5 bits (184), Expect = 4e-13
Identities = 82/395 (20%), Positives = 163/395 (41%), Gaps = 36/395 (9%)
Query: 173 TKSGAWFFGSGPQQTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDA 232
TKS + P++ ++ + + A ++ P +++A+ +S + A +
Sbjct: 501 TKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 560
Query: 233 APPSAPPDRSKGAEPSQ-----QALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALK 287
P + P++ + P++ +A P +++A S + ++ P E+ K+P E K
Sbjct: 561 PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP-EKAKSPVKEEAKSPAEAK 619
Query: 288 SERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRK 347
S K K+ A+ + KE +S K ++ +PEK A+ + K
Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679
Query: 348 EEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEG 407
+ P A+ PVK EE + A+ S + E + + A + A PE
Sbjct: 680 AKSPVKAEAKSPEKAKSPVK---EEAKSPEKAK-SPVKEEAKSPEKAKSPVKEEAKTPE- 734
Query: 408 KAGKRAPAAARASPPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQ 467
KA ++P A P+ ++ +T + ++P AK PA PA+ KA+
Sbjct: 735 KA--KSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK------TPAKEEARSPADKFPEKAK 786
Query: 468 EPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSD----QSESVRPSPPKPHRSKRGG 523
P++++ + EK ++ L+ D+ + + + E V+ SP K +
Sbjct: 787 SPVKEEVK------------SPEKAKSPLKEDAKAPEKEIPKKEEVK-SPVKEEEKPQEV 833
Query: 524 KKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSE 558
K ++ + EE+ +TP+ +D + E E
Sbjct: 834 KVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE 868
Score = 68.9 bits (167), Expect = 4e-11
Identities = 81/395 (20%), Positives = 164/395 (41%), Gaps = 48/395 (12%)
Query: 186 QTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPP----SAPPDR 241
+ ++ T + + ++ P +++A+ E+++S P+ A S + A P + P++
Sbjct: 636 EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS--PVKAEAKSPEKAKSPVKAEAKSPEK 693
Query: 242 SKG-----AEPSQQALGPEQKQASSRSRSEPP-RERKKTPGLSEQNGKGALKSERKRVPK 295
+K A+ ++A P +++A S +++ P +E KTP ++ K KS K
Sbjct: 694 AKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP 753
Query: 296 TSAQPVEGAVEERERKERRESRRL-----EKGRS--QDYPDTPEK-----RDEGKAADEE 343
A+ ++ E + + E+R EK +S ++ +PEK +++ KA ++E
Sbjct: 754 EKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKE 813
Query: 344 KQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAA 403
+KEE ++ + + VK PP++ + + ++ P+ EA
Sbjct: 814 IPKKEE-VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEA--- 869
Query: 404 LPEGKAGKRAPAAARASPPDSPRAYSAER-------TAETRAPGAKQLTNHSPPAPRHGP 456
P+ K ++ A A E T E AP ++ + P +
Sbjct: 870 -PKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEV 928
Query: 457 VPAEAPELKAQEPLR---KQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSP 513
E + KA+EP + K+ KAK+ + + + D++ S PS
Sbjct: 929 AKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSK 988
Query: 514 PKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCED 548
PK ++++ SSS ++ S P + ED
Sbjct: 989 PKAEKAEK---------SSSTDQKDSKPPEKATED 1014
Score = 68.6 bits (166), Expect = 5e-11
Identities = 98/405 (24%), Positives = 173/405 (42%), Gaps = 37/405 (9%)
Query: 207 EKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSRSE 266
EK+A+ +E + A ++ + P + A P ++A P +++A S + ++
Sbjct: 475 EKEAKEEEGKEEEGGEEEEAEGGEEE---TKSPPAEEAASPEKEAKSPVKEEAKSPAEAK 531
Query: 267 PP-RERKKTPG--LSEQNGKGALKSERKRVPKTSAQPVEGAVEERERK--ERRESRRLEK 321
P +E K+P S + K K E K P+ + E A E K E+ +S E+
Sbjct: 532 SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 591
Query: 322 GRSQDYPDTPEK-----RDEGKAADEEKQR-KEEDYQTRYRSDPNLARYPVKPPPEEQQM 375
+S +PEK ++E K+ E K KEE P A+ P K EE +
Sbjct: 592 AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK---EEAKS 648
Query: 376 RMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARASPPD---SPRAYSAER 432
A+ S + E + + A +A A PE KA ++P A A P+ SP A+
Sbjct: 649 PEKAK-SPEKEEAKSPEKAKSPVKAEAKSPE-KA--KSPVKAEAKSPEKAKSPVKEEAKS 704
Query: 433 TAETRAPGAKQLTNHSPPAPRHGPVPAEA--PELKAQEPLRKQSRLDPSSAVLMRKAKRE 490
+ ++P ++ + P PV EA PE KA+ P++++++ P A KAK
Sbjct: 705 PEKAKSPVKEEAKS---PEKAKSPVKEEAKTPE-KAKSPVKEEAK-SPEKAKSPEKAKTL 759
Query: 491 KVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMS---VSSSEEEGVSTPEYTSCE 547
V++ ++ + + E+ P+ P ++K K+ S S +E PE +
Sbjct: 760 DVKS---PEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPK 816
Query: 548 DVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKE 592
E++S E+ + +P E +P + + SK+
Sbjct: 817 KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKK 861
Score = 65.9 bits (159), Expect = 3e-10
Identities = 72/350 (20%), Positives = 140/350 (40%), Gaps = 29/350 (8%)
Query: 207 EKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSRSE 266
EK+ + E +T ++ ++ +G E + G E+ ++ +
Sbjct: 451 EKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAA 510
Query: 267 PPRERKKTPGLSEQNGKGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQD 326
P + K+P E KS K K+ A E + E+ +S E+ +S
Sbjct: 511 SPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA--------EVKSPEKAKSPAKEEAKSPP 562
Query: 327 YPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVK---PPPEEQQMRMHARVSR 383
+PEK + A+ + K + P A+ P K P EE + A+
Sbjct: 563 EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPV 622
Query: 384 ARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPGAKQ 443
+ ++V P E K+ ++A + P+ A S E+ AK
Sbjct: 623 KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS------PEKEEAKSPEKAKSPVKAEAKS 676
Query: 444 LTNHSPPAPRHGPVPAEA--PELKAQEPLRKQSRL-DPSSAVLMRKAKR-EKVETMLRND 499
P PV AEA PE KA+ P++++++ + + + + +AK EK ++ ++ +
Sbjct: 677 ------PEKAKSPVKAEAKSPE-KAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 729
Query: 500 SLSSDQSES-VRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCED 548
+ + ++++S V+ P ++K K + + V S E + + E S D
Sbjct: 730 AKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD 779
Score = 64.7 bits (156), Expect = 7e-10
Identities = 78/361 (21%), Positives = 150/361 (41%), Gaps = 43/361 (11%)
Query: 202 SEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPS-QQALGPEQKQAS 260
+E +KA+ + +++P + ++A P+ K P+ ++A PE+ ++
Sbjct: 596 AEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP 655
Query: 261 SRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLE 320
+ ++ P E+ K+P +K+E K P+ + PV+ E + E+ +S E
Sbjct: 656 EKEEAKSP-EKAKSP----------VKAEAKS-PEKAKSPVKA---EAKSPEKAKSPVKE 700
Query: 321 KGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHAR 380
+ +S + +P K +E K+ ++ K +E+ +T P A+ PVK + +
Sbjct: 701 EAKSPEKAKSPVK-EEAKSPEKAKSPVKEEAKT-----PEKAKSPVKEEAKSPEK----- 749
Query: 381 VSRARHERRHSDVALPRTEAGAALPEGKAGKRAPA---AARASPPDSPRAYSAERTAETR 437
+++ + + DV P + A K R+PA +A P S E+
Sbjct: 750 -AKSPEKAKTLDVKSPEAKTPA-----KEEARSPADKFPEKAKSPVKEEVKSPEKAKSPL 803
Query: 438 APGAKQLTNHSPPAPR-HGPVPAE--APELKAQEPLRKQSRLDPSSAVLMRKAKREKVET 494
AK P PV E E+K +EP +K + + K K E
Sbjct: 804 KEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEE 863
Query: 495 MLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESE 554
+ ++ E P+ KP SK KK + + +++ V TPE + VE++ +
Sbjct: 864 APKKEAPKPKVEEKKEPAVEKPKESKVEAKKEE----AEDKKKVPTPEKEAPAKVEVKED 919
Query: 555 S 555
+
Sbjct: 920 A 920
Score = 58.9 bits (141), Expect = 4e-08
Identities = 107/523 (20%), Positives = 198/523 (37%), Gaps = 77/523 (14%)
Query: 12 PPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAK-PAACKTP 70
P P +E + + E+ A + + E K K V++ AK PA K+P
Sbjct: 562 PEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSP 621
Query: 71 RNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGH 130
E + SP + E K ++ + + + K++A + A+
Sbjct: 622 VKEEAK----SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA--- 674
Query: 131 LCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQTSQD 190
K + V + + +K V + ++ KS P++ ++
Sbjct: 675 -------KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEK--AKSPVKEEAKSPEK-AKS 724
Query: 191 GTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQ 250
+ T ++ P +++A+ E+++S T S +A P+ RS + ++
Sbjct: 725 PVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEK 784
Query: 251 ALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTS--AQPVEGAVEER 308
A P +++ S +++ P K K+ K +PK PV+ + +
Sbjct: 785 AKSPVKEEVKSPEKAKSPL-------------KEDAKAPEKEIPKKEEVKSPVKEEEKPQ 831
Query: 309 ERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKP 368
E K + ++ E+ ++ P T EK+D K +K+ + + + + P
Sbjct: 832 EVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK--------KEPAVE 883
Query: 369 PPEEQQMRMHARVSRARHERRHSDVALPRTEAGA-------ALPEGK--AGKRAPAAARA 419
P+E ++ A+ A +++ V P EA A A P+ K K+ P A+A
Sbjct: 884 KPKES--KVEAKKEEAEDKKK---VPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKA 938
Query: 420 SPPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPS 479
P P AE+ + AP K P P E KA+E + S+ +PS
Sbjct: 939 KEPSKP----AEK--KEAAPEKKDTKEEKAKKPEEKP----KTEAKAKEDDKTLSK-EPS 987
Query: 480 SAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRG 522
K K EK E S S+DQ +S P ++ +G
Sbjct: 988 ------KPKAEKAE-----KSSSTDQKDSKPPEKATEDKAAKG 1019
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 73.6 bits (179), Expect = 2e-12
Identities = 49/144 (34%), Positives = 75/144 (52%), Gaps = 9/144 (6%)
Query: 1522 GLGPAQLVGRQTLATPAM---GDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVK 1578
G PA T A P G++++ + K +L + V+ R L Q + P PYVK
Sbjct: 1485 GTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGL-QLLQDGNDPDPYVK 1543
Query: 1579 VYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQG----KVLQVIVWGDYGRMDHKC 1634
+YLL + K+KT++ARKT +P Y + LV+D P+G + LQ+ V + G ++
Sbjct: 1544 IYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWEN-V 1602
Query: 1635 FMGVAQILLEELDLSSMVIGWYKL 1658
+G I L ELDL+ GW+ L
Sbjct: 1603 LLGEVNIRLRELDLAQEKTGWFAL 1626
Score = 68.9 bits (167), Expect = 4e-11
Identities = 40/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 748 VKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEP 807
VKL ++L + V+ L DG +PYVK+Y LPD +KR+TK +K P
Sbjct: 1508 VKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNP 1567
Query: 808 KWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIEL-ETALLDDEPHWYK 866
+N+ VY + + D ++R L+++V + E+ LGE+ I L E L ++ W+
Sbjct: 1568 TYNEMLVYDGIPKGDLQQRELQLSVLSEQGFW--ENVLLGEVNIRLRELDLAQEKTGWFA 1625
Query: 867 LQTHDESSL 875
L + +L
Sbjct: 1626 LGSRSHGTL 1634
>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 72.0 bits (175), Expect = 5e-12
Identities = 44/120 (36%), Positives = 66/120 (55%), Gaps = 2/120 (1%)
Query: 756 GHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVY 815
G +L V + +A +L A G + +VK Y LP R+ SKR+T +KK L P +N TFVY
Sbjct: 525 GGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVY 584
Query: 816 SHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSL 875
+ V D + LE+TVWD R ++FLG + + + T + + E + T +E SL
Sbjct: 585 NGVRLEDLQHMCLELTVWD--REPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSL 642
Score = 60.8 bits (146), Expect = 1e-08
Identities = 40/139 (28%), Positives = 70/139 (50%), Gaps = 9/139 (6%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPR-NPYVKMYFLPDRSDKSKRRTKTVK 802
G+++ L Y++ L+V+V + L + + R NPYVK Y LPD+S + KR+T +
Sbjct: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
Query: 803 KILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDE- 861
+ P +++T Y + +R L+ +VW R + FLGE I++++ LD +
Sbjct: 418 DTINPLYDETLRY-EIPESLLAQRTLQFSVWHHGRF--GRNTFLGEAEIQMDSWKLDKKL 474
Query: 862 ----PHWYKLQTHDESSLP 876
P K+ + LP
Sbjct: 475 DHCLPLHGKISAESPTGLP 493
Score = 55.8 bits (133), Expect = 3e-07
Identities = 41/129 (31%), Positives = 59/129 (45%), Gaps = 6/129 (4%)
Query: 1547 EDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQ 1606
E + L V V L +K PYVK YLL + + K+KT I R T++PLY +
Sbjct: 367 EQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDE 426
Query: 1607 SLVFDESPQG----KVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPS 1662
+L + E P+ + LQ VW +GR F+G A+I ++ L + L
Sbjct: 427 TLRY-EIPESLLAQRTLQFSVW-HHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKI 484
Query: 1663 SLVDPTLTP 1671
S PT P
Sbjct: 485 SAESPTGLP 493
Score = 47.8 bits (112), Expect = 9e-05
Identities = 47/197 (23%), Positives = 74/197 (37%), Gaps = 69/197 (35%)
Query: 19 MQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAENQPH 78
M EL DLS L+EEE+++I++V+ R +E + +E
Sbjct: 1 MSELLDLSFLSEEEKDLILSVLQRDEEVRKADE--------------------------- 33
Query: 79 QPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICH--------KTKFADGCGH 130
++ K ++ +I + + +H D TC C KT GC H
Sbjct: 34 -------KRIRRLKNELLEIKRKGAKRGSQHYSDR-TCARCQESLGRLSPKTNTCRGCNH 85
Query: 131 L-CSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQTSQ 189
L C CR + SN W C +C K+ E+ +G WF+
Sbjct: 86 LVCRDCRIQ-----------ESNG-----TWRCKVCAKEIELKKATGDWFY--------- 120
Query: 190 DGTLSDTATGAGSEVPR 206
D ++ A GSE+ R
Sbjct: 121 DQKVNRFAYRTGSEIIR 137
Score = 45.1 bits (105), Expect = 6e-04
Identities = 30/93 (32%), Positives = 48/93 (51%), Gaps = 5/93 (5%)
Query: 1536 TPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRI 1595
TP GD + + G+L+V + A++LT T +VK YLL +K+KT +
Sbjct: 511 TPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAG-GTSDSFVKGYLLPMRNKASKRKTPV 569
Query: 1596 ARKTLDPLYQQSLVFD----ESPQGKVLQVIVW 1624
+KTL+P Y + V++ E Q L++ VW
Sbjct: 570 MKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVW 602
>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 72.0 bits (175), Expect = 5e-12
Identities = 44/120 (36%), Positives = 66/120 (55%), Gaps = 2/120 (1%)
Query: 756 GHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVY 815
G +L V + +A +L A G + +VK Y LP R+ SKR+T +KK L P +N TFVY
Sbjct: 525 GGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVY 584
Query: 816 SHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSL 875
+ V D + LE+TVWD R ++FLG + + + T + + E + T +E SL
Sbjct: 585 NGVRLEDLQHMCLELTVWD--REPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSL 642
Score = 60.8 bits (146), Expect = 1e-08
Identities = 40/139 (28%), Positives = 70/139 (50%), Gaps = 9/139 (6%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPR-NPYVKMYFLPDRSDKSKRRTKTVK 802
G+++ L Y++ L+V+V + L + + R NPYVK Y LPD+S + KR+T +
Sbjct: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
Query: 803 KILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDE- 861
+ P +++T Y + +R L+ +VW R + FLGE I++++ LD +
Sbjct: 418 DTINPLYDETLRY-EIPESLLAQRTLQFSVWHHGRF--GRNTFLGEAEIQMDSWKLDKKL 474
Query: 862 ----PHWYKLQTHDESSLP 876
P K+ + LP
Sbjct: 475 DHCLPLHGKISAESPTGLP 493
Score = 55.8 bits (133), Expect = 3e-07
Identities = 41/129 (31%), Positives = 59/129 (45%), Gaps = 6/129 (4%)
Query: 1547 EDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQ 1606
E + L V V L +K PYVK YLL + + K+KT I R T++PLY +
Sbjct: 367 EQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDE 426
Query: 1607 SLVFDESPQG----KVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPS 1662
+L + E P+ + LQ VW +GR F+G A+I ++ L + L
Sbjct: 427 TLRY-EIPESLLAQRTLQFSVW-HHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKI 484
Query: 1663 SLVDPTLTP 1671
S PT P
Sbjct: 485 SAESPTGLP 493
Score = 47.8 bits (112), Expect = 9e-05
Identities = 47/197 (23%), Positives = 74/197 (37%), Gaps = 69/197 (35%)
Query: 19 MQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAENQPH 78
M EL DLS L+EEE+++I++V+ R +E + +E
Sbjct: 1 MSELLDLSFLSEEEKDLILSVLQRDEEVRKADE--------------------------- 33
Query: 79 QPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICH--------KTKFADGCGH 130
++ K ++ +I + + +H D TC C KT GC H
Sbjct: 34 -------KRIRRLKNELLEIKRKGAKRGSQHYSDR-TCARCQESLGRLSPKTNTCRGCNH 85
Query: 131 L-CSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQTSQ 189
L C CR + SN W C +C K+ E+ +G WF+
Sbjct: 86 LVCRDCRIQ-----------ESNG-----TWRCKVCAKEIELKKATGDWFY--------- 120
Query: 190 DGTLSDTATGAGSEVPR 206
D ++ A GSE+ R
Sbjct: 121 DQKVNRFAYRTGSEIIR 137
Score = 45.1 bits (105), Expect = 6e-04
Identities = 30/93 (32%), Positives = 48/93 (51%), Gaps = 5/93 (5%)
Query: 1536 TPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRI 1595
TP GD + + G+L+V + A++LT T +VK YLL +K+KT +
Sbjct: 511 TPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAG-GTSDSFVKGYLLPMRNKASKRKTPV 569
Query: 1596 ARKTLDPLYQQSLVFD----ESPQGKVLQVIVW 1624
+KTL+P Y + V++ E Q L++ VW
Sbjct: 570 MKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVW 602
>gi|14249614 synaptotagmin-like 1 [Homo sapiens]
Length = 550
Score = 71.6 bits (174), Expect = 6e-12
Identities = 64/183 (34%), Positives = 91/183 (49%), Gaps = 17/183 (9%)
Query: 700 PESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQL 759
P+ S + SSSSS S S S +S + +A QV G + L Y+ +L
Sbjct: 216 PDPSLDRMLSSSSSVSSLNSSTLSGSQMSLSGDA---EAVQVR-GSVHFALHYEPGAAEL 271
Query: 760 IVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVH 819
V+V+Q L A R +PYVK Y LPD+ +SKR+T K+ L P +N+T YS V
Sbjct: 272 RVHVIQCQGLAA-ARRRRSDPYVKSYLLPDK--QSKRKTAVKKRNLNPVFNETLRYS-VP 327
Query: 820 RRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQ 879
+ + + R+L ++VW R + FLGE+ + L+T EP W LQ P
Sbjct: 328 QAELQGRVLSLSVWH--RESLGRNIFLGEVEVPLDTWDWGSEPTWLPLQ-------PRVP 378
Query: 880 PSP 882
PSP
Sbjct: 379 PSP 381
Score = 50.4 bits (119), Expect = 1e-05
Identities = 38/123 (30%), Positives = 58/123 (47%), Gaps = 14/123 (11%)
Query: 722 PSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQ---------LIVNVLQATDL-PA 771
P+ + P P + D P G L++ L Y G + L V +A DL P
Sbjct: 368 PTWLPLQPRVPPSPDDLPS--RGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPL 425
Query: 772 RVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEIT 831
R + YV+ + LPD S S++RT+ V++ L P +N T VY D R+ E++
Sbjct: 426 RAGSL--DTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELS 483
Query: 832 VWD 834
+WD
Sbjct: 484 LWD 486
Score = 45.4 bits (106), Expect = 5e-04
Identities = 44/164 (26%), Positives = 73/164 (44%), Gaps = 16/164 (9%)
Query: 1535 ATPAMGDIQIGMEDKKG--QLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKK 1592
A G + + + G +L V VI+ + L +S P YVK YLL + +K+K
Sbjct: 251 AVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAARRRRSDP--YVKSYLLPDKQ--SKRK 306
Query: 1593 TRIARKTLDPLYQQSL---VFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLS 1649
T + ++ L+P++ ++L V QG+VL + VW + F+G ++ L+ D
Sbjct: 307 TAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVW-HRESLGRNIFLGEVEVPLDTWDWG 365
Query: 1650 SMVIGWYKLFP-----PSSLVDPTLTPLTRRASQSSLESSTGPP 1688
S W L P P L L L+ + + E + PP
Sbjct: 366 SEPT-WLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPP 408
Score = 35.8 bits (81), Expect = 0.36
Identities = 19/62 (30%), Positives = 38/62 (61%), Gaps = 4/62 (6%)
Query: 1551 GQLEVEVIRARSLTQ-KPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLV 1609
G+L V AR L + GS T YV+ ++L + + ++++TR+ R++L P++ ++V
Sbjct: 410 GELHFWVKEARDLLPLRAGSLDT---YVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMV 466
Query: 1610 FD 1611
+D
Sbjct: 467 YD 468
Score = 33.9 bits (76), Expect = 1.4
Identities = 21/60 (35%), Positives = 29/60 (48%), Gaps = 5/60 (8%)
Query: 9 GPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACK 68
GP+P T + L DLS LTEEE+ I V+ R + EE + + +A P K
Sbjct: 23 GPKPET-----EGLLDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLRASVADPGQLK 77
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 71.2 bits (173), Expect = 8e-12
Identities = 87/393 (22%), Positives = 142/393 (36%), Gaps = 47/393 (11%)
Query: 41 DRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAENQPHQPSPRLHQQFESYKE-QVRKIG 99
DR + +KE+ V +P + ++ + R+ + E +E + +IG
Sbjct: 18 DRPLQSNDKEQLQAGWSVHPGGQPDRQRKQEELTDEEKEIINRVIARAEKMEEMEQERIG 77
Query: 100 EEARRYQGEHK----DDAPTCGICHKTKFADGCGHL-CSYCRTKFCARCGGRVSLRSNNE 154
R + K D C +C + G + C C+ C +CG + R ++
Sbjct: 78 RLVDRLENMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETNNRLHS- 136
Query: 155 DKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQTSQDGTLSDTATGAGSEVPREKKARLQE 214
+W+C +C +Q+E+ +SGAWFF P+Q +P+ +
Sbjct: 137 ----VWLCKICIEQREVWKRSGAWFFKGFPKQV----------------LPQPMPIK--- 173
Query: 215 RSRSQTPLSTAAASSQDAAPPSAP---PDR--SKGAEPSQQALGPEQKQASSRSRSEPPR 269
+++ Q P+S AA Q A P P P R S+ Q GP+ A R PP
Sbjct: 174 KTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDPASAPGRGNYGPPV 233
Query: 270 ERKKTPGLSEQNGKGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPD 329
R +S + +S P G + R + + + P
Sbjct: 234 RRASEARMSSSSRDSESWDHSGGAGDSSRSPA-GLRRANSVQASRPAPGSVQSPAPPQPG 292
Query: 330 TPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERR 389
P + R + SDP PP EE+ + + E R
Sbjct: 293 QPGTPGGSRPGPGPAGRFPDQKPEVAPSDPG----TTAPPREERTGGVGGYPAVGAREDR 348
Query: 390 HSDVALPRTEAGAALPEGKAGKRAPAAARASPP 422
S + P ++A AA P+ PAAAR PP
Sbjct: 349 MSHPSGPYSQASAAAPQ-------PAAARQPPP 374
Score = 65.5 bits (158), Expect = 4e-10
Identities = 36/111 (32%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G L L YD+ L +++A L +PYVK++ LP S +K RTKT++
Sbjct: 394 GALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRN 453
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELE 854
P WN+T VY + D + + L I+V D+ + +EF+GE L+
Sbjct: 454 TRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF--GHNEFIGETRFSLK 502
Score = 60.5 bits (145), Expect = 1e-08
Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 4/123 (3%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G++ V L Y LIV +++ L A +P+VK++ PD K+K +T+ KK
Sbjct: 552 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKK 611
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPH 863
L P++N+ F Y H D ++ L+I+VWD + ++++G + + +A + H
Sbjct: 612 TLNPEFNEEFFYDIKH-SDLAKKSLDISVWDYD--IGKSNDYIGGCQLGI-SAKGERLKH 667
Query: 864 WYK 866
WY+
Sbjct: 668 WYE 670
Score = 45.8 bits (107), Expect = 4e-04
Identities = 32/105 (30%), Positives = 55/105 (52%), Gaps = 8/105 (7%)
Query: 1547 EDKKGQLEVEVIRARSLTQKP-GSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQ 1605
+ L+ +I+A+ L KP S PYVK++LL + K +T+ R T +P++
Sbjct: 403 DQDNSSLQCTIIKAKGL--KPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWN 460
Query: 1606 QSLVF----DESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEEL 1646
++LV+ DE Q K L++ V D + H F+G + L++L
Sbjct: 461 ETLVYHGITDEDMQRKTLRISVC-DEDKFGHNEFIGETRFSLKKL 504
Score = 35.4 bits (80), Expect = 0.47
Identities = 28/96 (29%), Positives = 47/96 (48%), Gaps = 5/96 (5%)
Query: 1549 KKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSL 1608
++G L V +IR L + + P+VK++L + AK KT+I +KTL+P + +
Sbjct: 563 QQGGLIVGIIRCVHLAAMDANGYSD-PFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEF 621
Query: 1609 VFD---ESPQGKVLQVIVWGDYGRMDHKCFMGVAQI 1641
+D K L + VW DY ++G Q+
Sbjct: 622 FYDIKHSDLAKKSLDISVW-DYDIGKSNDYIGGCQL 656
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 70.5 bits (171), Expect = 1e-11
Identities = 45/124 (36%), Positives = 69/124 (55%), Gaps = 8/124 (6%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G++S L Y QL+V +LQA DLPA+ +PYVK+Y LPDR K K +TK +K
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDR--KKKFQTKVHRK 358
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLD---D 860
L P +N+TF +S V + +R L +V+D R + +G+++++ L + D
Sbjct: 359 TLNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRFSRH--DLIGQVVLDNLLELAEQPPD 415
Query: 861 EPHW 864
P W
Sbjct: 416 RPLW 419
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/93 (34%), Positives = 51/93 (54%), Gaps = 3/93 (3%)
Query: 1551 GQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVF 1610
G+L V +I+A +L + + PYVK L+ G + K+KT I + TL+P Y ++LVF
Sbjct: 446 GRLTVTIIKASNLKAMDLTGFSD-PYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
Query: 1611 DESPQG--KVLQVIVWGDYGRMDHKCFMGVAQI 1641
D +P+ V I DY + H +GV ++
Sbjct: 505 DVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537
Score = 38.1 bits (87), Expect = 0.073
Identities = 31/124 (25%), Positives = 53/124 (42%), Gaps = 3/124 (2%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G+L+ L Y +L V +++A++L A +PYVK + + KR+T K
Sbjct: 433 GELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKN 492
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPH 863
L P +N+ V+ V L I V D + +E +G + + A H
Sbjct: 493 TLNPTYNEALVFD-VAPESVENVGLSIAVVDYDCI--GHNEVIGVCRVGPDAADPHGREH 549
Query: 864 WYKL 867
W ++
Sbjct: 550 WAEM 553
Score = 37.4 bits (85), Expect = 0.12
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 3/59 (5%)
Query: 1552 QLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVF 1610
QL V +++A L K S PYVK+YLL + K +T++ RKTL+P++ ++ F
Sbjct: 315 QLVVRILQALDLPAKD-SNGFSDPYVKIYLLPDRK--KKFQTKVHRKTLNPVFNETFQF 370
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 70.5 bits (171), Expect = 1e-11
Identities = 45/124 (36%), Positives = 69/124 (55%), Gaps = 8/124 (6%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G++S L Y QL+V +LQA DLPA+ +PYVK+Y LPDR K K +TK +K
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDR--KKKFQTKVHRK 358
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLD---D 860
L P +N+TF +S V + +R L +V+D R + +G+++++ L + D
Sbjct: 359 TLNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRFSRH--DLIGQVVLDNLLELAEQPPD 415
Query: 861 EPHW 864
P W
Sbjct: 416 RPLW 419
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/93 (34%), Positives = 51/93 (54%), Gaps = 3/93 (3%)
Query: 1551 GQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVF 1610
G+L V +I+A +L + + PYVK L+ G + K+KT I + TL+P Y ++LVF
Sbjct: 446 GRLTVTIIKASNLKAMDLTGFSD-PYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
Query: 1611 DESPQG--KVLQVIVWGDYGRMDHKCFMGVAQI 1641
D +P+ V I DY + H +GV ++
Sbjct: 505 DVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537
Score = 38.1 bits (87), Expect = 0.073
Identities = 31/124 (25%), Positives = 53/124 (42%), Gaps = 3/124 (2%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G+L+ L Y +L V +++A++L A +PYVK + + KR+T K
Sbjct: 433 GELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKN 492
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPH 863
L P +N+ V+ V L I V D + +E +G + + A H
Sbjct: 493 TLNPTYNEALVFD-VAPESVENVGLSIAVVDYDCI--GHNEVIGVCRVGPDAADPHGREH 549
Query: 864 WYKL 867
W ++
Sbjct: 550 WAEM 553
Score = 37.4 bits (85), Expect = 0.12
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 3/59 (5%)
Query: 1552 QLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVF 1610
QL V +++A L K S PYVK+YLL + K +T++ RKTL+P++ ++ F
Sbjct: 315 QLVVRILQALDLPAKD-SNGFSDPYVKIYLLPDRK--KKFQTKVHRKTLNPVFNETFQF 370
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 70.5 bits (171), Expect = 1e-11
Identities = 45/124 (36%), Positives = 69/124 (55%), Gaps = 8/124 (6%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G++S L Y QL+V +LQA DLPA+ +PYVK+Y LPDR K K +TK +K
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDR--KKKFQTKVHRK 358
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLD---D 860
L P +N+TF +S V + +R L +V+D R + +G+++++ L + D
Sbjct: 359 TLNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRFSRH--DLIGQVVLDNLLELAEQPPD 415
Query: 861 EPHW 864
P W
Sbjct: 416 RPLW 419
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/93 (34%), Positives = 51/93 (54%), Gaps = 3/93 (3%)
Query: 1551 GQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVF 1610
G+L V +I+A +L + + PYVK L+ G + K+KT I + TL+P Y ++LVF
Sbjct: 446 GRLTVTIIKASNLKAMDLTGFSD-PYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
Query: 1611 DESPQG--KVLQVIVWGDYGRMDHKCFMGVAQI 1641
D +P+ V I DY + H +GV ++
Sbjct: 505 DVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537
Score = 38.1 bits (87), Expect = 0.073
Identities = 31/124 (25%), Positives = 53/124 (42%), Gaps = 3/124 (2%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G+L+ L Y +L V +++A++L A +PYVK + + KR+T K
Sbjct: 433 GELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKN 492
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPH 863
L P +N+ V+ V L I V D + +E +G + + A H
Sbjct: 493 TLNPTYNEALVFD-VAPESVENVGLSIAVVDYDCI--GHNEVIGVCRVGPDAADPHGREH 549
Query: 864 WYKL 867
W ++
Sbjct: 550 WAEM 553
Score = 37.4 bits (85), Expect = 0.12
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 3/59 (5%)
Query: 1552 QLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVF 1610
QL V +++A L K S PYVK+YLL + K +T++ RKTL+P++ ++ F
Sbjct: 315 QLVVRILQALDLPAKD-SNGFSDPYVKIYLLPDRK--KKFQTKVHRKTLNPVFNETFQF 370
>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
Length = 910
Score = 69.3 bits (168), Expect = 3e-11
Identities = 157/784 (20%), Positives = 290/784 (36%), Gaps = 149/784 (19%)
Query: 154 EDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQTSQDGTLSDTATGAGSEVPREKKARLQ 213
E++ V + + Q++ SG WF+ + ++ +D A R + A Q
Sbjct: 29 EEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKR-HRDKIHGADIIRASMRKKRPQIAAEQ 87
Query: 214 ERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSRSEPPRERKK 273
+ R + + A PP+ + E PE+ A + S
Sbjct: 88 SKDRENGAKESWVNNVNKDA--FLPPELAGVVEE------PEEDAAPASPSSSVVNPASS 139
Query: 274 TPGLSEQNG-KGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPE 332
+S++N K + E+++ P S++ EG ++ + E+ ++ R ++ + E
Sbjct: 140 VIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSE 199
Query: 333 KRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSD 392
+++ AD Q+ E+ QT
Sbjct: 200 SKEKSTVADTSIQKLEKSKQT--------------------------------------- 220
Query: 393 VALPRTEAGAAL--PEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPGAKQLTNHSPP 450
LP G+ + P KA K + + D+ +++ +RT +A GA
Sbjct: 221 --LPGLSNGSQIKAPIPKARKMIYKSTDLNKDDN-QSFPRQRTDSLKARGA--------- 268
Query: 451 APRHGPVPAEAPELKAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVR 510
PR + E LR +P S ++ + + + S + + S
Sbjct: 269 -PRGILKRNSSSSSTDSETLRYNHNFEPKSKIV---SPGLTIHERISEKEHSLEDNSSPN 324
Query: 511 PSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDP- 569
P H + K ++ S G E++ E L++ + + GD + + DP
Sbjct: 325 SLEPLKH-VRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKN-GMEDAGDTEEFQSDPK 382
Query: 570 -------ATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKR--TTMPKDSGALLGLKV 620
+ +H +SP S T QP G I + + T P+ +
Sbjct: 383 PSQYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINE 442
Query: 621 VGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATN-------EEVY 673
K ++L RL + + + S AD + H +E +PG ++ EE
Sbjct: 443 PKDKSSELTRLESVLPR----SPADELSHC------VEPEPSQVPGGSSRDRQQGSEEEP 492
Query: 674 NIILESKSEPQVEIIVSRPIGDIPRIPESS----HPPLESSSSSFESQKMER-------- 721
+ +L++ + S+ + DI + + P E S+ + +K ++
Sbjct: 493 SPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDDEKPDQKPVTNECV 552
Query: 722 PSISVISPTSPG-------ALKDAPQVLP-------------------GQLSVK------ 749
P IS + PT P LK + +P G L VK
Sbjct: 553 PRISTV-PTQPDNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNIQFA 611
Query: 750 LWYDKVGHQLIVNVLQATDLPAR-VDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPK 808
+ Y + +L V V Q DL A V + +PYVK Y LPD+ K++T VKK L P
Sbjct: 612 IEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPV 671
Query: 809 WNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPH----W 864
+N+ Y + ++ + + L +++W R + + FLGE+ ++LET D++ + W
Sbjct: 672 YNEILRYK-IEKQILKTQKLNLSIWH--RDTFKRNSFLGEVELDLETWDWDNKQNKQLRW 728
Query: 865 YKLQ 868
Y L+
Sbjct: 729 YPLK 732
Score = 58.5 bits (140), Expect = 5e-08
Identities = 41/127 (32%), Positives = 61/127 (48%), Gaps = 20/127 (15%)
Query: 734 ALKDAPQVLPGQL-----SVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLP 788
AL+ P+ +PG+ V +W V + DLP + G N +VK LP
Sbjct: 751 ALQYVPEPVPGKKLPTTGEVHIW-----------VKECLDLPL-LRGSHLNSFVKCTILP 798
Query: 789 DRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGE 848
D S KS+++T+ V K P +N T VY D E +E+TVWD ++ ++FLG
Sbjct: 799 DTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL---TNQFLGG 855
Query: 849 ILIELET 855
+ I T
Sbjct: 856 LRIGFGT 862
Score = 50.1 bits (118), Expect = 2e-05
Identities = 37/127 (29%), Positives = 59/127 (46%), Gaps = 9/127 (7%)
Query: 1540 GDIQIGME--DKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIAR 1597
G+IQ +E + +L V V + + L K PYVK YLL + + KKKT + +
Sbjct: 606 GNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVK 665
Query: 1598 KTLDPLYQQSLVFDESPQ---GKVLQVIVWGDYGRMDHKCFMGVAQILLEELD---LSSM 1651
KTL+P+Y + L + Q + L + +W F+G ++ LE D +
Sbjct: 666 KTLNPVYNEILRYKIEKQILKTQKLNLSIW-HRDTFKRNSFLGEVELDLETWDWDNKQNK 724
Query: 1652 VIGWYKL 1658
+ WY L
Sbjct: 725 QLRWYPL 731
Score = 31.2 bits (69), Expect = 8.9
Identities = 21/95 (22%), Positives = 46/95 (48%), Gaps = 17/95 (17%)
Query: 1537 PAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIA 1596
P G++ I +++ L++ ++R L +VK +L + + +++KTR
Sbjct: 765 PTTGEVHIWVKEC---LDLPLLRGSHLNS----------FVKCTILPDTSRKSRQKTRAV 811
Query: 1597 RKTLDPLYQQSLVFD----ESPQGKVLQVIVWGDY 1627
KT +P++ ++V+D E +++ VW Y
Sbjct: 812 GKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHY 846
>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
Length = 1104
Score = 69.3 bits (168), Expect = 3e-11
Identities = 60/199 (30%), Positives = 96/199 (48%), Gaps = 17/199 (8%)
Query: 684 QVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMER--PSISVISPTSPGALK--DAP 739
Q+ I+VS+ G + SH SSSS E ++ P I+ +P L D+P
Sbjct: 909 QLGILVSQHSG----VEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTHVDSP 964
Query: 740 QVLP----GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGR-PRNPYVKMYFLPDRSDKS 794
P GQ+ + LWY +L+ V L R +GR P +PYV + LPD++ +
Sbjct: 965 LEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSL--RQNGRDPPDPYVSLLLLPDKNRGT 1022
Query: 795 KRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIEL- 853
KRRT K+ L P++N+ F + + + + R L+++V E E LG++ ++L
Sbjct: 1023 KRRTSQKKRTLSPEFNERFEW-ELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLA 1081
Query: 854 ETALLDDEPHWYKLQTHDE 872
ET L WY L + +
Sbjct: 1082 ETDLSQGVARWYDLMDNKD 1100
Score = 38.9 bits (89), Expect = 0.043
Identities = 31/102 (30%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 1561 RSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFD---ESPQGK 1617
RSL Q + P PYV + LL + K++T ++TL P + + ++ + Q +
Sbjct: 996 RSLRQN--GRDPPDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRR 1053
Query: 1618 VLQVIVWGDYGRMD-HKCFMGVAQILLEELDLSSMVIGWYKL 1658
L V V + M + +G Q+ L E DLS V WY L
Sbjct: 1054 KLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVARWYDL 1095
Score = 37.4 bits (85), Expect = 0.12
Identities = 35/108 (32%), Positives = 55/108 (50%), Gaps = 19/108 (17%)
Query: 757 HQLIVNVLQATDLPAR-------VDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKW 809
H L ++VL+A DL A+ V G+ +PYVK+ L RS +S V++ L P+W
Sbjct: 647 HVLRIHVLEAQDLIAKDRFLGGLVKGKS-DPYVKLK-LAGRSFRSH----VVREDLNPRW 700
Query: 810 NQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETAL 857
N+ F V + LE+ V+D+ ++ +FLG + L T L
Sbjct: 701 NEVF---EVIVTSVPGQELEVEVFDK---DLDKDDFLGRCKVRLTTVL 742
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 69.3 bits (168), Expect = 3e-11
Identities = 86/388 (22%), Positives = 140/388 (36%), Gaps = 61/388 (15%)
Query: 41 DRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGE 100
DRQ+++EE + + + R +A+ E + RL + E+ ++ V
Sbjct: 38 DRQRKQEELTDEEKEIINRVIARA------EKMEEMEQERIGRLVDRLENMRKNVAG--- 88
Query: 101 EARRYQGEHKDDAPTCGICHKTKFADGCGHL-CSYCRTKFCARCGGRVSLRSNNEDKVVM 159
D C +C + G + C C+ C +CG + R ++ +
Sbjct: 89 ----------DGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETNNRLHS-----V 133
Query: 160 WVCNLCRKQQEILTKSGAWFFGSGPQQTSQDGTLSDTATGAGSEVPREKKARLQERSRSQ 219
W+C +C +Q+E+ +SGAWFF P+Q +P+ + +++ Q
Sbjct: 134 WLCKICIEQREVWKRSGAWFFKGFPKQV----------------LPQPMPIK---KTKPQ 174
Query: 220 TPLSTAAASSQDAAPPSAP---PDR--SKGAEPSQQALGPEQKQASSRSRSEPPRERKKT 274
P+S AA Q A P P P R S+ Q GP+ A R PP R
Sbjct: 175 QPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDPASAPGRGNYGPPVRRASE 234
Query: 275 PGLSEQNGKGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKR 334
+S + +S P G + R + + + P P
Sbjct: 235 ARMSSSSRDSESWDHSGGAGDSSRSPA-GLRRANSVQASRPAPGSVQSPAPPQPGQPGTP 293
Query: 335 DEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVA 394
+ R + SDP PP EE+ + + E R S +
Sbjct: 294 GGSRPGPGPAGRFPDQKPEVAPSDPG----TTAPPREERTGGVGGYPAVGAREDRMSHPS 349
Query: 395 LPRTEAGAALPEGKAGKRAPAAARASPP 422
P ++A AA P+ PAAAR PP
Sbjct: 350 GPYSQASAAAPQ-------PAAARQPPP 370
Score = 65.5 bits (158), Expect = 4e-10
Identities = 36/111 (32%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G L L YD+ L +++A L +PYVK++ LP S +K RTKT++
Sbjct: 390 GALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRN 449
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELE 854
P WN+T VY + D + + L I+V D+ + +EF+GE L+
Sbjct: 450 TRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF--GHNEFIGETRFSLK 498
Score = 60.5 bits (145), Expect = 1e-08
Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 4/123 (3%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G++ V L Y LIV +++ L A +P+VK++ PD K+K +T+ KK
Sbjct: 548 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKK 607
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPH 863
L P++N+ F Y H D ++ L+I+VWD + ++++G + + +A + H
Sbjct: 608 TLNPEFNEEFFYDIKH-SDLAKKSLDISVWDYD--IGKSNDYIGGCQLGI-SAKGERLKH 663
Query: 864 WYK 866
WY+
Sbjct: 664 WYE 666
Score = 45.8 bits (107), Expect = 4e-04
Identities = 32/105 (30%), Positives = 55/105 (52%), Gaps = 8/105 (7%)
Query: 1547 EDKKGQLEVEVIRARSLTQKP-GSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQ 1605
+ L+ +I+A+ L KP S PYVK++LL + K +T+ R T +P++
Sbjct: 399 DQDNSSLQCTIIKAKGL--KPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWN 456
Query: 1606 QSLVF----DESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEEL 1646
++LV+ DE Q K L++ V D + H F+G + L++L
Sbjct: 457 ETLVYHGITDEDMQRKTLRISVC-DEDKFGHNEFIGETRFSLKKL 500
Score = 35.4 bits (80), Expect = 0.47
Identities = 28/96 (29%), Positives = 47/96 (48%), Gaps = 5/96 (5%)
Query: 1549 KKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSL 1608
++G L V +IR L + + P+VK++L + AK KT+I +KTL+P + +
Sbjct: 559 QQGGLIVGIIRCVHLAAMDANGYSD-PFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEF 617
Query: 1609 VFD---ESPQGKVLQVIVWGDYGRMDHKCFMGVAQI 1641
+D K L + VW DY ++G Q+
Sbjct: 618 FYDIKHSDLAKKSLDISVW-DYDIGKSNDYIGGCQL 652
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 68.9 bits (167), Expect = 4e-11
Identities = 46/128 (35%), Positives = 66/128 (51%), Gaps = 6/128 (4%)
Query: 743 PGQL--SVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKT 800
PGQ+ +VKL L + V+ DL DG NPYVK Y LPD SKR+TK
Sbjct: 1556 PGQIGGAVKLSISYRNGTLFIMVMHIKDLVTE-DGADPNPYVKTYLLPDNHKTSKRKTKI 1614
Query: 801 VKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDD 860
+K P +N+ VYS + R+R L+++V ++ E+ FLG + + L+ L
Sbjct: 1615 SRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLR--ENFFLGGVTLPLKDFNLSK 1672
Query: 861 EP-HWYKL 867
E WY+L
Sbjct: 1673 ETVKWYQL 1680
Score = 59.3 bits (142), Expect = 3e-08
Identities = 36/123 (29%), Positives = 67/123 (54%), Gaps = 7/123 (5%)
Query: 1540 GDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKT 1599
G +++ + + G L + V+ + L + G+ P PYVK YLL + +K+KT+I+RKT
Sbjct: 1561 GAVKLSISYRNGTLFIMVMHIKDLVTEDGAD--PNPYVKTYLLPDNHKTSKRKTKISRKT 1618
Query: 1600 LDPLYQQSLVFD----ESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGW 1655
+P + + LV+ E+ + + LQ+ V + F+G + L++ +LS + W
Sbjct: 1619 RNPTFNEMLVYSGYSKETLRQRELQLSVLSAES-LRENFFLGGVTLPLKDFNLSKETVKW 1677
Query: 1656 YKL 1658
Y+L
Sbjct: 1678 YQL 1680
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 67.8 bits (164), Expect = 9e-11
Identities = 44/126 (34%), Positives = 67/126 (53%), Gaps = 6/126 (4%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G+L L YD +QL V VLQA +LPA G +PYVK++ LPD+ K K TK +K
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDK--KKKYETKVHRK 198
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDE-P 862
L P +N+TF + V ++ + L + ++D R + + +GE+ + + T L
Sbjct: 199 TLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRFSKH--DIIGEVKVPMNTVDLGQPIE 255
Query: 863 HWYKLQ 868
W LQ
Sbjct: 256 EWRDLQ 261
Score = 48.9 bits (115), Expect = 4e-05
Identities = 30/83 (36%), Positives = 50/83 (60%), Gaps = 5/83 (6%)
Query: 1551 GQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVF 1610
G+L V ++ A++L +K PYVK++L++NG + KKKT + +KTL+P + +S F
Sbjct: 285 GKLTVCILEAKNL-KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSF 343
Query: 1611 D---ESPQGKVLQVIVWGDYGRM 1630
+ E Q KV V+ DY ++
Sbjct: 344 EIPFEQIQ-KVQVVVTVLDYDKL 365
Score = 46.2 bits (108), Expect = 3e-04
Identities = 31/119 (26%), Positives = 61/119 (51%), Gaps = 4/119 (3%)
Query: 733 GALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSD 792
G K+ P+ L G + L Y +L V +L+A +L G +PYVK++ + +
Sbjct: 262 GGEKEEPEKL-GDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKR 320
Query: 793 KSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILI 851
K++T KK L P +N++F + + ++ + +TV D ++ + E+ +G+I +
Sbjct: 321 LKKKKTTVKKKTLNPYFNESFSF-EIPFEQIQKVQVVVTVLDYDKLGKNEA--IGKIFV 376
Score = 45.4 bits (106), Expect = 5e-04
Identities = 38/142 (26%), Positives = 66/142 (46%), Gaps = 9/142 (6%)
Query: 1522 GLGPAQLVGRQTLATPAMGDIQIGMED--KKGQLEVEVIRARSLTQKPGSKSTPAPYVKV 1579
GL + G + +G +Q ++ + QL V V++A L T PYVKV
Sbjct: 123 GLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMG-GTSDPYVKV 181
Query: 1580 YLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQ---GKVLQVIVWGDYGRMDHKCFM 1636
+LL + K +T++ RKTL+P + ++ F Q GK L + ++ D+ R +
Sbjct: 182 FLLPDKK--KKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIY-DFDRFSKHDII 238
Query: 1637 GVAQILLEELDLSSMVIGWYKL 1658
G ++ + +DL + W L
Sbjct: 239 GEVKVPMNTVDLGQPIEEWRDL 260
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 67.8 bits (164), Expect = 9e-11
Identities = 44/126 (34%), Positives = 67/126 (53%), Gaps = 6/126 (4%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G+L L YD +QL V VLQA +LPA G +PYVK++ LPD+ K K TK +K
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDK--KKKYETKVHRK 198
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDE-P 862
L P +N+TF + V ++ + L + ++D R + + +GE+ + + T L
Sbjct: 199 TLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRFSKH--DIIGEVKVPMNTVDLGQPIE 255
Query: 863 HWYKLQ 868
W LQ
Sbjct: 256 EWRDLQ 261
Score = 48.9 bits (115), Expect = 4e-05
Identities = 30/83 (36%), Positives = 50/83 (60%), Gaps = 5/83 (6%)
Query: 1551 GQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVF 1610
G+L V ++ A++L +K PYVK++L++NG + KKKT + +KTL+P + +S F
Sbjct: 285 GKLTVCILEAKNL-KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSF 343
Query: 1611 D---ESPQGKVLQVIVWGDYGRM 1630
+ E Q KV V+ DY ++
Sbjct: 344 EIPFEQIQ-KVQVVVTVLDYDKL 365
Score = 46.2 bits (108), Expect = 3e-04
Identities = 31/119 (26%), Positives = 61/119 (51%), Gaps = 4/119 (3%)
Query: 733 GALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSD 792
G K+ P+ L G + L Y +L V +L+A +L G +PYVK++ + +
Sbjct: 262 GGEKEEPEKL-GDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKR 320
Query: 793 KSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILI 851
K++T KK L P +N++F + + ++ + +TV D ++ + E+ +G+I +
Sbjct: 321 LKKKKTTVKKKTLNPYFNESFSF-EIPFEQIQKVQVVVTVLDYDKLGKNEA--IGKIFV 376
Score = 45.4 bits (106), Expect = 5e-04
Identities = 38/142 (26%), Positives = 66/142 (46%), Gaps = 9/142 (6%)
Query: 1522 GLGPAQLVGRQTLATPAMGDIQIGMED--KKGQLEVEVIRARSLTQKPGSKSTPAPYVKV 1579
GL + G + +G +Q ++ + QL V V++A L T PYVKV
Sbjct: 123 GLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMG-GTSDPYVKV 181
Query: 1580 YLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQ---GKVLQVIVWGDYGRMDHKCFM 1636
+LL + K +T++ RKTL+P + ++ F Q GK L + ++ D+ R +
Sbjct: 182 FLLPDKK--KKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIY-DFDRFSKHDII 238
Query: 1637 GVAQILLEELDLSSMVIGWYKL 1658
G ++ + +DL + W L
Sbjct: 239 GEVKVPMNTVDLGQPIEEWRDL 260
>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 67.4 bits (163), Expect = 1e-10
Identities = 31/80 (38%), Positives = 49/80 (61%)
Query: 756 GHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVY 815
G L V + +A +L A G + +VK Y LPD S +K +T +KK + P+WN TF++
Sbjct: 586 GGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMF 645
Query: 816 SHVHRRDFRERMLEITVWDQ 835
S +H +D + LE+T+WD+
Sbjct: 646 SGIHPQDIKNVCLELTIWDK 665
Score = 50.4 bits (119), Expect = 1e-05
Identities = 62/268 (23%), Positives = 120/268 (44%), Gaps = 44/268 (16%)
Query: 654 DEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSS 713
++ + K +PGA +++ ++E ++ +VS ++ ++H L S S+
Sbjct: 338 EDTVSIRSKSVPGALDKDSLE-----ETEESIDALVSS------QLSTNTHR-LASGLST 385
Query: 714 FESQKMERPSISVISPTSP-GALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPAR 772
M +SV S T G +K + ++L L + Y G L + V +L
Sbjct: 386 TSLNSM----MSVYSETGDYGNVKVSGEIL---LHISYCYKTGG--LYIFVKNCRNLAIG 436
Query: 773 VDGRPR-NPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEIT 831
+ + R + YVK Y LPD+S +KR+TK ++ P++N+T Y+ H + R L+++
Sbjct: 437 DEKKQRTDAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYTISHTQ-LETRTLQLS 494
Query: 832 VWDQPRVQEEESEFLGEILIELETALLDD-EPHWYKLQTHDESSLPL------------- 877
VW R + FLGE+ I ++ ++ W+ LQ E + +
Sbjct: 495 VWHYDRF--GRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLR 552
Query: 878 ---PQPSPFMPRRHIHGESSSKKLQRSQ 902
P+ + +P + G + KK ++ +
Sbjct: 553 YIPPEENLMLPPEQLQGNKTFKKGKKKE 580
Score = 45.1 bits (105), Expect = 6e-04
Identities = 79/371 (21%), Positives = 142/371 (38%), Gaps = 55/371 (14%)
Query: 1303 KQTTGSGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSST 1362
K TG S +LD + + R + SD++D RT +SR +
Sbjct: 203 KTDTGRSYSLDLDGQHFRSLKSPPGSDRG------STGSSDLNDQEPGPRTPKSSRSNGV 256
Query: 1363 SFMSEQSERPRGRISSFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGT 1422
+ ++ S P R + + R G + + + + T H + ++
Sbjct: 257 TPGTQSSPAPSTRTVT---SVISREYGFENSMDLAAIEGTSQELTKSHRRNTSGTPSIAV 313
Query: 1423 VGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMV 1482
G +SLS+ +S S+L +ES + + T+ +++ A + K
Sbjct: 314 SG-------TSLSS---------DQSRSELDLSESFTEDSEDTVSIRSKSVPGA-LDKDS 356
Query: 1483 RQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTL--ATPAMG 1540
+ + ES D ++S S RL + GL L ++ T G
Sbjct: 357 LEETEESIDALVSSQLSTNTH-----RLAS---------GLSTTSLNSMMSVYSETGDYG 402
Query: 1541 DIQIGMED--------KKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKK 1592
++++ E K G L + V R+L K YVK YLL + + K+K
Sbjct: 403 NVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRK 462
Query: 1593 TRIARKTLDPLYQQSLVFDESP---QGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLS 1649
T+I R +P + ++L + S + + LQ+ VW Y R F+G +I + +
Sbjct: 463 TKI-RTGTNPEFNETLKYTISHTQLETRTLQLSVW-HYDRFGRNSFLGEVEIPFDSWNFE 520
Query: 1650 SMVIGWYKLFP 1660
+ W+ L P
Sbjct: 521 NPTDEWFVLQP 531
Score = 44.3 bits (103), Expect = 0.001
Identities = 70/321 (21%), Positives = 108/321 (33%), Gaps = 76/321 (23%)
Query: 93 EQVRKIGEE---ARRYQGEHKDDAP-TCGICHKTK-FADGCGHLCSYCRTKFCARCGGRV 147
+++RK+ E A+R G+ + +A C CH+ G C C + C C RV
Sbjct: 37 KRIRKLKNELLEAKRRSGKTQQEASRVCVHCHRNLGLIFDRGDPCQACSLRVCREC--RV 94
Query: 148 SLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFG-------------------------- 181
+ + + W C +C K ++ +G WFF
Sbjct: 95 AGPNGS------WKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSP 148
Query: 182 -----SGPQQTSQDGTLSDTATGAGSEV----PREK-----KARLQERSRSQTPLSTAAA 227
+QT QD SDT+ AG + P+ K K R R TP +
Sbjct: 149 GAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKTDTGR 208
Query: 228 S------SQDAAPPSAPPDRSKGAEPS----QQALGPEQKQASSRSRSEPPRERKKTPGL 277
S Q +PP +G+ S Q GP + SSRS P + +P
Sbjct: 209 SYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPK-SSRSNGVTP-GTQSSPAP 266
Query: 278 SEQNGKGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEG 337
S + + E +EG +E + RR + TP G
Sbjct: 267 STRTVTSVISREYGFENSMDLAAIEGTSQELTKSHRRNT-----------SGTPSIAVSG 315
Query: 338 KAADEEKQRKEEDYQTRYRSD 358
+ ++ R E D + D
Sbjct: 316 TSLSSDQSRSELDLSESFTED 336
Score = 35.4 bits (80), Expect = 0.47
Identities = 31/119 (26%), Positives = 54/119 (45%), Gaps = 9/119 (7%)
Query: 1523 LGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLL 1582
L P QL G +T + + G LEV + A++LT S T +VK YLL
Sbjct: 562 LPPEQLQGNKTFKKGKKKESPV---ISGGILEVFIKEAKNLTAVK-SGGTSDSFVKGYLL 617
Query: 1583 ENGACIAKKKTRIARKTLDPLYQQSLVFD----ESPQGKVLQVIVWGDYGRMDHKCFMG 1637
+ + K KT + +K+++P + + +F + + L++ +W D F+G
Sbjct: 618 PDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIW-DKEAFSSNIFLG 675
>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
Length = 752
Score = 67.4 bits (163), Expect = 1e-10
Identities = 31/80 (38%), Positives = 49/80 (61%)
Query: 756 GHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVY 815
G L V + +A +L A G + +VK Y LPD S +K +T +KK + P+WN TF++
Sbjct: 608 GGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMF 667
Query: 816 SHVHRRDFRERMLEITVWDQ 835
S +H +D + LE+T+WD+
Sbjct: 668 SGIHPQDIKNVCLELTIWDK 687
Score = 50.8 bits (120), Expect = 1e-05
Identities = 54/217 (24%), Positives = 98/217 (45%), Gaps = 34/217 (15%)
Query: 705 PPLESSSSSFESQKMERPSISVISPTSP-GALKDAPQVLPGQLSVKLWYDKVGHQLIVNV 763
P +S ++S S +SV S T G +K + ++L L + Y G L + V
Sbjct: 401 PDADSDTTSLNSM------MSVYSETGDYGNVKVSGEIL---LHISYCYKTGG--LYIFV 449
Query: 764 LQATDLPARVDGRPR-NPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRD 822
+L + + R + YVK Y LPD+S +KR+TK ++ P++N+T Y+ H +
Sbjct: 450 KNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYTISHTQ- 507
Query: 823 FRERMLEITVWDQPRVQEEESEFLGEILIELETALLDD-EPHWYKLQTHDESSLPL---- 877
R L+++VW R + FLGE+ I ++ ++ W+ LQ E + +
Sbjct: 508 LETRTLQLSVWHYDRF--GRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQY 565
Query: 878 ------------PQPSPFMPRRHIHGESSSKKLQRSQ 902
P+ + +P + G + KK ++ +
Sbjct: 566 KGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKE 602
Score = 45.4 bits (106), Expect = 5e-04
Identities = 80/375 (21%), Positives = 135/375 (36%), Gaps = 41/375 (10%)
Query: 1303 KQTTGSGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSST 1362
K TG S +LD + + R + SD++D RT +SR +
Sbjct: 203 KTDTGRSYSLDLDGQHFRSLKSPPGSDRG------STGSSDLNDQEPGPRTPKSSRSNGV 256
Query: 1363 SFMSEQSERPRGRISSFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGT 1422
+ ++ S P R + + R G + + + + T H + ++
Sbjct: 257 TPGTQSSPAPSTRTVT---SVISREYGFENSMDLAAIEGTSQELTKSHRRNTSGTPSIAV 313
Query: 1423 VGAGGKKRRS--------SLSAKVVAIVSRRSRST------SQLSQTESGHKKLKSTIQR 1468
G +S S + VS RS+S L +TE L S+ Q
Sbjct: 314 SGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETEESIDALVSS-QL 372
Query: 1469 STETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQL 1528
ST T A Q + +N ++ + + S+ D+ G ++
Sbjct: 373 STNTHRLASGLSTSSQAGSDRKWTYLNVPDADSDTTSLNSMMSVYSETGDY----GNVKV 428
Query: 1529 VGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACI 1588
G L I K G L + V R+L K YVK YLL + +
Sbjct: 429 SGEILL--------HISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRN 480
Query: 1589 AKKKTRIARKTLDPLYQQSLVFDESP---QGKVLQVIVWGDYGRMDHKCFMGVAQILLEE 1645
K+KT+I R +P + ++L + S + + LQ+ VW Y R F+G +I +
Sbjct: 481 NKRKTKI-RTGTNPEFNETLKYTISHTQLETRTLQLSVW-HYDRFGRNSFLGEVEIPFDS 538
Query: 1646 LDLSSMVIGWYKLFP 1660
+ + W+ L P
Sbjct: 539 WNFENPTDEWFVLQP 553
Score = 44.3 bits (103), Expect = 0.001
Identities = 70/321 (21%), Positives = 108/321 (33%), Gaps = 76/321 (23%)
Query: 93 EQVRKIGEE---ARRYQGEHKDDAP-TCGICHKTK-FADGCGHLCSYCRTKFCARCGGRV 147
+++RK+ E A+R G+ + +A C CH+ G C C + C C RV
Sbjct: 37 KRIRKLKNELLEAKRRSGKTQQEASRVCVHCHRNLGLIFDRGDPCQACSLRVCREC--RV 94
Query: 148 SLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFG-------------------------- 181
+ + + W C +C K ++ +G WFF
Sbjct: 95 AGPNGS------WKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSP 148
Query: 182 -----SGPQQTSQDGTLSDTATGAGSEV----PREK-----KARLQERSRSQTPLSTAAA 227
+QT QD SDT+ AG + P+ K K R R TP +
Sbjct: 149 GAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKTDTGR 208
Query: 228 S------SQDAAPPSAPPDRSKGAEPS----QQALGPEQKQASSRSRSEPPRERKKTPGL 277
S Q +PP +G+ S Q GP + SSRS P + +P
Sbjct: 209 SYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPK-SSRSNGVTP-GTQSSPAP 266
Query: 278 SEQNGKGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEG 337
S + + E +EG +E + RR + TP G
Sbjct: 267 STRTVTSVISREYGFENSMDLAAIEGTSQELTKSHRRNT-----------SGTPSIAVSG 315
Query: 338 KAADEEKQRKEEDYQTRYRSD 358
+ ++ R E D + D
Sbjct: 316 TSLSSDQSRSELDLSESFTED 336
Score = 35.4 bits (80), Expect = 0.47
Identities = 31/119 (26%), Positives = 54/119 (45%), Gaps = 9/119 (7%)
Query: 1523 LGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLL 1582
L P QL G +T + + G LEV + A++LT S T +VK YLL
Sbjct: 584 LPPEQLQGNKTFKKGKKKESPV---ISGGILEVFIKEAKNLTAVK-SGGTSDSFVKGYLL 639
Query: 1583 ENGACIAKKKTRIARKTLDPLYQQSLVFD----ESPQGKVLQVIVWGDYGRMDHKCFMG 1637
+ + K KT + +K+++P + + +F + + L++ +W D F+G
Sbjct: 640 PDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIW-DKEAFSSNIFLG 697
>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 67.4 bits (163), Expect = 1e-10
Identities = 31/80 (38%), Positives = 49/80 (61%)
Query: 756 GHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVY 815
G L V + +A +L A G + +VK Y LPD S +K +T +KK + P+WN TF++
Sbjct: 586 GGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMF 645
Query: 816 SHVHRRDFRERMLEITVWDQ 835
S +H +D + LE+T+WD+
Sbjct: 646 SGIHPQDIKNVCLELTIWDK 665
Score = 50.4 bits (119), Expect = 1e-05
Identities = 62/268 (23%), Positives = 120/268 (44%), Gaps = 44/268 (16%)
Query: 654 DEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSS 713
++ + K +PGA +++ ++E ++ +VS ++ ++H L S S+
Sbjct: 338 EDTVSIRSKSVPGALDKDSLE-----ETEESIDALVSS------QLSTNTHR-LASGLST 385
Query: 714 FESQKMERPSISVISPTSP-GALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPAR 772
M +SV S T G +K + ++L L + Y G L + V +L
Sbjct: 386 TSLNSM----MSVYSETGDYGNVKVSGEIL---LHISYCYKTGG--LYIFVKNCRNLAIG 436
Query: 773 VDGRPR-NPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEIT 831
+ + R + YVK Y LPD+S +KR+TK ++ P++N+T Y+ H + R L+++
Sbjct: 437 DEKKQRTDAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYTISHTQ-LETRTLQLS 494
Query: 832 VWDQPRVQEEESEFLGEILIELETALLDD-EPHWYKLQTHDESSLPL------------- 877
VW R + FLGE+ I ++ ++ W+ LQ E + +
Sbjct: 495 VWHYDRF--GRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLR 552
Query: 878 ---PQPSPFMPRRHIHGESSSKKLQRSQ 902
P+ + +P + G + KK ++ +
Sbjct: 553 YIPPEENLMLPPEQLQGNKTFKKGKKKE 580
Score = 45.1 bits (105), Expect = 6e-04
Identities = 79/371 (21%), Positives = 142/371 (38%), Gaps = 55/371 (14%)
Query: 1303 KQTTGSGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSST 1362
K TG S +LD + + R + SD++D RT +SR +
Sbjct: 203 KTDTGRSYSLDLDGQHFRSLKSPPGSDRG------STGSSDLNDQEPGPRTPKSSRSNGV 256
Query: 1363 SFMSEQSERPRGRISSFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGT 1422
+ ++ S P R + + R G + + + + T H + ++
Sbjct: 257 TPGTQSSPAPSTRTVT---SVISREYGFENSMDLAAIEGTSQELTKSHRRNTSGTPSIAV 313
Query: 1423 VGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMV 1482
G +SLS+ +S S+L +ES + + T+ +++ A + K
Sbjct: 314 SG-------TSLSS---------DQSRSELDLSESFTEDSEDTVSIRSKSVPGA-LDKDS 356
Query: 1483 RQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTL--ATPAMG 1540
+ + ES D ++S S RL + GL L ++ T G
Sbjct: 357 LEETEESIDALVSSQLSTNTH-----RLAS---------GLSTTSLNSMMSVYSETGDYG 402
Query: 1541 DIQIGMED--------KKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKK 1592
++++ E K G L + V R+L K YVK YLL + + K+K
Sbjct: 403 NVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRK 462
Query: 1593 TRIARKTLDPLYQQSLVFDESP---QGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLS 1649
T+I R +P + ++L + S + + LQ+ VW Y R F+G +I + +
Sbjct: 463 TKI-RTGTNPEFNETLKYTISHTQLETRTLQLSVW-HYDRFGRNSFLGEVEIPFDSWNFE 520
Query: 1650 SMVIGWYKLFP 1660
+ W+ L P
Sbjct: 521 NPTDEWFVLQP 531
Score = 44.3 bits (103), Expect = 0.001
Identities = 70/321 (21%), Positives = 108/321 (33%), Gaps = 76/321 (23%)
Query: 93 EQVRKIGEE---ARRYQGEHKDDAP-TCGICHKTK-FADGCGHLCSYCRTKFCARCGGRV 147
+++RK+ E A+R G+ + +A C CH+ G C C + C C RV
Sbjct: 37 KRIRKLKNELLEAKRRSGKTQQEASRVCVHCHRNLGLIFDRGDPCQACSLRVCREC--RV 94
Query: 148 SLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFG-------------------------- 181
+ + + W C +C K ++ +G WFF
Sbjct: 95 AGPNGS------WKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSP 148
Query: 182 -----SGPQQTSQDGTLSDTATGAGSEV----PREK-----KARLQERSRSQTPLSTAAA 227
+QT QD SDT+ AG + P+ K K R R TP +
Sbjct: 149 GAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKTDTGR 208
Query: 228 S------SQDAAPPSAPPDRSKGAEPS----QQALGPEQKQASSRSRSEPPRERKKTPGL 277
S Q +PP +G+ S Q GP + SSRS P + +P
Sbjct: 209 SYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPK-SSRSNGVTP-GTQSSPAP 266
Query: 278 SEQNGKGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEG 337
S + + E +EG +E + RR + TP G
Sbjct: 267 STRTVTSVISREYGFENSMDLAAIEGTSQELTKSHRRNT-----------SGTPSIAVSG 315
Query: 338 KAADEEKQRKEEDYQTRYRSD 358
+ ++ R E D + D
Sbjct: 316 TSLSSDQSRSELDLSESFTED 336
Score = 35.4 bits (80), Expect = 0.47
Identities = 31/119 (26%), Positives = 54/119 (45%), Gaps = 9/119 (7%)
Query: 1523 LGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLL 1582
L P QL G +T + + G LEV + A++LT S T +VK YLL
Sbjct: 562 LPPEQLQGNKTFKKGKKKESPV---ISGGILEVFIKEAKNLTAVK-SGGTSDSFVKGYLL 617
Query: 1583 ENGACIAKKKTRIARKTLDPLYQQSLVFD----ESPQGKVLQVIVWGDYGRMDHKCFMG 1637
+ + K KT + +K+++P + + +F + + L++ +W D F+G
Sbjct: 618 PDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIW-DKEAFSSNIFLG 675
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 66.6 bits (161), Expect = 2e-10
Identities = 42/138 (30%), Positives = 65/138 (47%), Gaps = 5/138 (3%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G L L YD+ L ++L+A L +PYVK++ LP +K +TKT +
Sbjct: 91 GTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRN 150
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPH 863
L P WN+ YS + D ++L I V D+ ++ +EF+GEI + L + H
Sbjct: 151 TLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKL--SHNEFIGEIRVPLRRLKPSQKKH 208
Query: 864 WYKLQTHDESSLPLPQPS 881
+ E +PL PS
Sbjct: 209 F---NICLERQVPLASPS 223
Score = 57.8 bits (138), Expect = 9e-08
Identities = 32/91 (35%), Positives = 46/91 (50%), Gaps = 1/91 (1%)
Query: 744 GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKK 803
G++ + L Y L+V +L+ L A +PYVK Y PD KSK +T KK
Sbjct: 253 GRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKK 312
Query: 804 ILEPKWNQTFVYSHVHRRDFRERMLEITVWD 834
L P++N+ F Y + + LE+TVWD
Sbjct: 313 TLNPEFNEEFFY-EIELSTLATKTLEVTVWD 342
Score = 45.1 bits (105), Expect = 6e-04
Identities = 36/100 (36%), Positives = 56/100 (56%), Gaps = 10/100 (10%)
Query: 1553 LEVEVIRARSLTQKPGSKSTPA-PYVKVYLLENGACIAKK-KTRIARKTLDPLYQQSLVF 1610
L ++RA+ L KP + A PYVK++LL GAC A K KT+ R TL+P++ + L +
Sbjct: 106 LHCSILRAKGL--KPMDFNGLADPYVKLHLLP-GACKANKLKTKTQRNTLNPVWNEDLTY 162
Query: 1611 ----DESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEEL 1646
D+ KVL++ V D ++ H F+G ++ L L
Sbjct: 163 SGITDDDITHKVLRIAVC-DEDKLSHNEFIGEIRVPLRRL 201
Score = 34.3 bits (77), Expect = 1.1
Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 4/66 (6%)
Query: 1575 PYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFD---ESPQGKVLQVIVWGDYGRMD 1631
PYVK YL + +K KT + +KTL+P + + ++ + K L+V VW DY
Sbjct: 289 PYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVW-DYDIGK 347
Query: 1632 HKCFMG 1637
F+G
Sbjct: 348 SNDFIG 353
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 66.6 bits (161), Expect = 2e-10
Identities = 86/363 (23%), Positives = 147/363 (40%), Gaps = 67/363 (18%)
Query: 202 SEVPREKKAR----LQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEP-SQQALGPEQ 256
S P +++R + RSRS+TP + S+ A RS+ P +++
Sbjct: 586 SRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARR-----RSRTRSPVRRRSRSRSP 640
Query: 257 KQASSRSRSEPP----RERKKTPGLSEQNGKGALKSERKRVPKTSAQPVEGAVEERERKE 312
+ S RSRS P R R +TP + G+ ++ +R ++ ++ R R
Sbjct: 641 ARRSGRSRSRTPARRGRSRSRTPA---RRGRSRSRTPARRSGRSRSRTPARRGRSRSRTP 697
Query: 313 RR---ESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPP 369
RR SR L + R + + TP++R ++ E K K Q R RS+ +
Sbjct: 698 RRGRSRSRSLVR-RGRSHSRTPQRRGRSGSSSERKN-KSRTSQRRSRSNSS--------- 746
Query: 370 PEEQQMRMHARVSRARHERRH---SDVALPRTEAGAALPEGKAGKRAPAAARASPPDSPR 426
PE ++ R+ +R SR+ R S ++L R+ +G++ P +PP R
Sbjct: 747 PEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSS--------PCPKQKSQTPPRRSR 798
Query: 427 AYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEA--------PELKAQEPLRKQSRLDP 478
+ S++ A++R P + ++ SPP + P+ P++K+ P R+ S P
Sbjct: 799 SGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSP 858
Query: 479 SSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGV 538
+ N+ + Q S S P P R + S SS
Sbjct: 859 QA-----------------NEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKS 901
Query: 539 STP 541
STP
Sbjct: 902 STP 904
Score = 62.4 bits (150), Expect = 4e-09
Identities = 76/377 (20%), Positives = 140/377 (37%), Gaps = 44/377 (11%)
Query: 205 PREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDR-SKGAEPSQQALGPEQKQASSRS 263
P + + ++RS ++P +SS +++PPS P + S+ A S ++ P S R
Sbjct: 393 PPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHRE 452
Query: 264 RSEPPRERKKTPGLSEQN-----------GKGALKSERKRVPKTSAQPVEGAVEERERKE 312
S P + ++ G ++++ G+ + KR S P + +
Sbjct: 453 ISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQ 512
Query: 313 RRESRRLEK-GRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRS-DPNLARYPVKPPP 370
R SR ++ GRS+ +P++R ++ + + Q R RS R + P
Sbjct: 513 WRRSRSAQRWGRSR----SPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPA 568
Query: 371 EEQQMRMHARVSRARHE-----RRHSDVALP---RTEAGAALPEGKAGKRAPAAARASPP 422
+ R R R RR S P R+ + G++ R PA R+
Sbjct: 569 TRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTR 628
Query: 423 DSPRAYSAERT------------------AETRAPGAKQLTNHSPPAPRHGPVPAEAPEL 464
R S R+ + +R P + + PA R G + P
Sbjct: 629 SPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPAR 688
Query: 465 KAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGK 524
+ + R R S L+R+ + R S SS + ++ + + RS +
Sbjct: 689 RGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPE 748
Query: 525 KRQMSVSSSEEEGVSTP 541
++ +SS +S+P
Sbjct: 749 MKKSRISSRRSRSLSSP 765
Score = 57.8 bits (138), Expect = 9e-08
Identities = 88/387 (22%), Positives = 135/387 (34%), Gaps = 55/387 (14%)
Query: 181 GSGPQQTSQDGTLSDTATGAGS----EVPREKKARLQERSRSQTPLSTAAASSQDAAPPS 236
GS P GT S + S ++PR E S P + + PS
Sbjct: 1442 GSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPS 1501
Query: 237 APPDRSKGAEPSQQALGPE----QKQAS-----SRSRSEPPRERKKTPGLSEQNGKGALK 287
+P +K P ++ G E QK + RSRS +E P S Q +
Sbjct: 1502 SPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQE-----R 1556
Query: 288 SERKRVPKTSAQ---PV-----EGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKA 339
SE P + A+ P+ G+ E + K R RR G S PE +D+ +A
Sbjct: 1557 SESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSS------PEVKDKPRA 1610
Query: 340 ADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTE 399
A + + + + + L R + + S H +
Sbjct: 1611 APRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARR 1670
Query: 400 AGAALPEGKAGKRAPAAARASPPDSPRAYSAERTAETR-APGAKQLTNHSPPAPRHGP-V 457
+ PE K R P R+S A + +R A + + + +PP R P V
Sbjct: 1671 GSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSV 1730
Query: 458 PAEAPELKAQEPLRKQSRLDPSSAVLMR-----------------KAKREKVETMLRNDS 500
+ P K++ R++S P + R +++REK T R D
Sbjct: 1731 SSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDR 1790
Query: 501 LSSDQSESVR----PSPPKPHRSKRGG 523
S QS S R S + R +RGG
Sbjct: 1791 SGSSQSTSRRRQRSRSRSRVTRRRRGG 1817
Score = 57.4 bits (137), Expect = 1e-07
Identities = 135/579 (23%), Positives = 208/579 (35%), Gaps = 93/579 (16%)
Query: 952 RSVSPHRGNDQGKPRSR--LPNVPLQRSLDEIHPTRR--SRSPTRHHDASRSPVDHRTRD 1007
R+ S R + P + LP P +RS P R S +P+RH + SP
Sbjct: 1412 RTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPR 1471
Query: 1008 VDSQYLSEQDS--ELLMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYS 1065
S+ SE DS E LP+ R RS + + K L P+ S S
Sbjct: 1472 TPSRGRSECDSSPEPKALPQTPRPRS----RSPSSPELNNKCLTPQRERSGSESS----- 1522
Query: 1066 SILPAHTKTKSVTRQDISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTS 1125
K+V R + +S E+ V +R+ S S+ + T
Sbjct: 1523 ------VDQKTVARTPLGQRSRSGSS------QELDVKPSASPQERSESDSSPDSKAKTR 1570
Query: 1126 LHSPERERGRWSPSLDRRRPPSPRIQIQHASPENDRHSRKSERS---------------- 1169
+R R SP +D + SPR +SPE R + R+
Sbjct: 1571 TPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPR 1630
Query: 1170 SIQKQTRKGTASDAERVLP------------TCLSRRGHAAPRATDQPVIRGKHPARSRS 1217
++ +++R G++S P SR R++ +P + + P R RS
Sbjct: 1631 ALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRS 1690
Query: 1218 SEHSS--IRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQS--PPADTSFSSRRGRQLPQ 1273
S S R S+P + T +RSP+ S PA+ S SSRR R
Sbjct: 1691 SRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASS 1750
Query: 1274 VPVRSGSIEQASL------VVEERTRQMKMKVHRFKQTTGSGSSQELDREQY---SKYNI 1324
++ S S + R+R + K ++ SGSSQ R + S+ +
Sbjct: 1751 PRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRV 1810
Query: 1325 HKDQ-----YRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQS-ERPRGRIS- 1377
+ + Y S +SS + SRT SR S S S +R R R S
Sbjct: 1811 TRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASP 1870
Query: 1378 -------SFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKR 1430
S TP + RR + + + S S T + S + +R
Sbjct: 1871 ATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVS---------RR 1921
Query: 1431 RSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRS 1469
RS ++ + RRSRS + ++ S + T +RS
Sbjct: 1922 RS--RSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRS 1958
Score = 56.6 bits (135), Expect = 2e-07
Identities = 87/414 (21%), Positives = 132/414 (31%), Gaps = 53/414 (12%)
Query: 194 SDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPS-APPDRSKGAEPSQQAL 252
S + G E P + S PL+T S + PPS A P R + S + L
Sbjct: 353 SPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKL 412
Query: 253 GPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPK--TSAQPVEGAVEERER 310
SS +P + + E + + TS G + +
Sbjct: 413 PQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKS 472
Query: 311 KERRESRRLEKGRS-------QDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDP---N 360
SRR+ + RS + TP KR ++ + +R + P
Sbjct: 473 HSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRG 532
Query: 361 LARYPVKPP-PEEQQMRMHARVSRARHERRHSDVALPRTEAGAALP--EGKAGKRAPAAA 417
+R P +P + + R AR R HS R + + P G++ R PA
Sbjct: 533 RSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARR 592
Query: 418 RASPPDSPRAYSAERT------AETRAPGAKQLTNHSP---------PAPRHG------- 455
R+ R S RT + +R P ++ SP PA R G
Sbjct: 593 RSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTP 652
Query: 456 --------PVPAEAPELKAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSE 507
PA +++ P R+ R S + + R + T R S S
Sbjct: 653 ARRGRSRSRTPARRGRSRSRTPARRSGR---SRSRTPARRGRSRSRTPRRGRSRSRSLVR 709
Query: 508 SVRPSPPKPHRSKRGG----KKRQMSVSSSEEEGVSTPEYTSCEDVELESESVS 557
R P R R G +K + S S+PE S S+S
Sbjct: 710 RGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLS 763
Score = 53.1 bits (126), Expect = 2e-06
Identities = 76/372 (20%), Positives = 134/372 (36%), Gaps = 41/372 (11%)
Query: 195 DTATGAGSEVPREKKA-----RLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQ 249
D G E P ++ A +L E + + AA D+ + D + A ++
Sbjct: 102 DVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAK 161
Query: 250 QALGPE--------QKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQPV 301
Q PE ++ +SSRS + +++KK ++ + + ERK+ K
Sbjct: 162 QP-APEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRS 220
Query: 302 EGAVEERER-----KERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYR 356
E ++R+ K +R+S+ ++ RS+ P+ R ++ + + ++R R
Sbjct: 221 ESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSR 280
Query: 357 SDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAA 416
S + A S + R + P +E G + +
Sbjct: 281 S-----------AAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATK 329
Query: 417 ARASPPDSPRAYSAERTAETRAPG-AKQLTNHSPPAP------RHGPVPAEAPELKAQEP 469
+SP + E++A +P + T PPAP RHG +P+ A P
Sbjct: 330 QPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHG----GSPQPLATTP 385
Query: 470 LRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMS 529
L ++ PS A R K L S S S +P+ H S +
Sbjct: 386 LSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAP 445
Query: 530 VSSSEEEGVSTP 541
S E S+P
Sbjct: 446 APGSHREISSSP 457
Score = 52.0 bits (123), Expect = 5e-06
Identities = 152/648 (23%), Positives = 217/648 (33%), Gaps = 117/648 (18%)
Query: 878 PQPSPFMPRRHIHGESSSKKLQRSQR---ISDSDISDYEVDDGIGV--------VPPVGY 926
P P + H E + KK +R + ISDS + D PP Y
Sbjct: 112 PGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPY 171
Query: 927 RSSARESKSTTLTVPEQQRTTH-----HRSRSVSP------------HRGNDQGKPRSRL 969
S RES S+ P+Q++ RS S SP HR + K R
Sbjct: 172 -SLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHR 230
Query: 970 PNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSELLMLPRAKRG 1029
P + + +RSRS T A +S HR+ DS S+ R++
Sbjct: 231 SPTPKSKRKSKDKKRKRSRSTT---PAPKSRRAHRSTSADSASSSDTS-------RSRSR 280
Query: 1030 RSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSIL-PAHTKT------KSVTRQDI 1082
+A HTT L + P S + P T T ++ T+Q
Sbjct: 281 SAAAKTHTT--------ALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPS 332
Query: 1083 SLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSLHSPERERGRWSPSLDR 1142
S + + + D+ S +P RS ST P + ER G P
Sbjct: 333 SPYED-------KDKDKKEKSATRPSPSPERS-STGPEPPAPTPLLAERHGGSPQPLATT 384
Query: 1143 RRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPRAT 1202
P ASP DR KS Q + + + + PT +SR ++P +
Sbjct: 385 PLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQ---PTKVSRHASSSPESP 441
Query: 1203 DQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADTS 1262
G H R SS +S S PS RM R RSP
Sbjct: 442 KPAPAPGSH--REISSSPTSKNRSHGRAKRDKSHSHTPS---RRMGRSRSPA-------- 488
Query: 1263 FSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKY 1322
+++RGR + P + G R+R + + R Q G S
Sbjct: 489 -TAKRGRSRSRTPTKRG---------HSRSRSPQWRRSRSAQRWGRSRS----------- 527
Query: 1323 NIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFTPK 1382
Q R + S + R+ SA R S S +S RGR S TP
Sbjct: 528 ----PQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHS----RSPATRGRSRSRTPA 579
Query: 1383 MQGR-RMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAI 1441
+GR R T R +S + + S++ G + RR S + +
Sbjct: 580 RRGRSRSRTPARRRSRSRTPT------RRRSRSRTPARRGRSRSRTPARRRS---RTRSP 630
Query: 1442 VSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRES 1489
V RRSRS S ++ + + RS A R R P+R S
Sbjct: 631 VRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRS 678
Score = 52.0 bits (123), Expect = 5e-06
Identities = 124/482 (25%), Positives = 177/482 (36%), Gaps = 81/482 (16%)
Query: 863 HWYKLQTHDESSLPLPQP---SPFMPRRHIHGESSSKKLQRSQRISDSDISDYEVDDGIG 919
H K +T S P+P S PRR SS +L R R+S S +
Sbjct: 1661 HPPKSRTARRGSRSSPEPKTKSRTPPRRR--SSRSSPELTRKARLSRRSRSASSSPETRS 1718
Query: 920 VVPPVGYRS----------SARESKSTTLTVPEQQRTTHHRSRSVSPH-RGNDQGKPRSR 968
PP RS +R S+ + +TT R RS SP RG + + RSR
Sbjct: 1719 RTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSR 1778
Query: 969 LPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRD---VDSQYLSEQDSELLMLPR 1025
R D + +S S R SRS V R R S+ + Q+S R
Sbjct: 1779 REKTRTTRRRDR-SGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTS-SR 1836
Query: 1026 AKRGRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTKTKSVTRQDISLH 1085
+RGRS PP +S S PA K +S +R + H
Sbjct: 1837 RRRGRSRT---------------PP-------TSRKRSRSRTSPAPWK-RSRSRASPATH 1873
Query: 1086 HECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSLHSPERERGRWSPSLDRRR- 1144
+ T L + S P R + T+ R R R R SP RR
Sbjct: 1874 RRSRSRTPL-ISRRRSRSRTSPVSRRRSRSRTSVTR--------RRSRSRASPVSRRRSR 1924
Query: 1145 ---PPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPRA 1201
PP R + + +P R SR ++++R T R + S R+
Sbjct: 1925 SRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRS 1984
Query: 1202 TDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADT 1261
PV R + +RSR+S + R+ + SP+ R+RS +++PPA
Sbjct: 1985 RTSPVTRRR--SRSRTSPVTRRRS-----------RSRTSPVT----RRRSRSRTPPAIR 2027
Query: 1262 SFSSRRGRQLPQVPVRSGS---IEQASLVVEERTRQMKMKVHR----FKQTTGSGSSQEL 1314
S R LP+ RS S I + S RT + K + R ++ + SGSS +
Sbjct: 2028 RRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDR 2087
Query: 1315 DR 1316
R
Sbjct: 2088 SR 2089
Score = 48.1 bits (113), Expect = 7e-05
Identities = 155/712 (21%), Positives = 235/712 (33%), Gaps = 134/712 (18%)
Query: 923 PVGYRSSARESKSTTLTVPEQQRT-THHRSRSVSPHRGNDQGKPRSRLPNVPLQRSLDEI 981
P + ++ KS T P +R+ T + +P G L PL S + +
Sbjct: 334 PYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPL--SQEPV 391
Query: 982 HPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSELLMLPRAKRGRSAECLHTTRHL 1041
+P + SPTR +SP LP++ S+ +
Sbjct: 392 NPPSEA-SPTRDRSPPKSPEK--------------------LPQSSSSESSPPSPQPTKV 430
Query: 1042 VRHYKTLP--PKMPLLQSSSHWNIYSSILPAHTKTKSVTRQDISLHHECFNSTVLRFTDE 1099
RH + P PK P SH I SS +K +S R H S + +
Sbjct: 431 SRHASSSPESPK-PAPAPGSHREISSS---PTSKNRSHGRAKRDKSHSHTPSRRMGRSRS 486
Query: 1100 ILVSELQPFLDRARSAS-TNCLRPDTSLHSPERERGRWSPSLDRRRPPSPRIQIQHASPE 1158
++ R RS S T R + SP+ R R + R R P R + +
Sbjct: 487 PATAK------RGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRP 540
Query: 1159 NDRHSRKSERSSIQKQTRKGTASDAE-----RVLPTCLSRRGHAAPRATDQPVIRGKHPA 1213
SR ++R + R+G + R +RRG + R + R + P
Sbjct: 541 GWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPT 600
Query: 1214 RSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADTSFSSRRGRQLPQ 1273
R RS + R G S +P R R RSP + S + R GR +
Sbjct: 601 RRRSRSRTPARR---------GRSRSRTPA-RRRSRTRSPVRRRSRSRSPARRSGRSRSR 650
Query: 1274 VPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNIHKDQYRSCD 1333
P R G + R+R + +G S+ R S+
Sbjct: 651 TPARRGRSRSRTPARRGRSRSRTP-----ARRSGRSRSRTPARRGRSR------------ 693
Query: 1334 NVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFTPKMQGRRMGTSGR 1393
SRT R S S + RGR S TP+ +GR +S R
Sbjct: 694 -----------------SRTPRRGRSRSRSLVR------RGRSHSRTPQRRGRSGSSSER 730
Query: 1394 SIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLS 1453
TS + SS K I SRRSRS S
Sbjct: 731 KNKSRTS------------------------QRRSRSNSSPEMKKSRISSRRSRSLS--- 763
Query: 1454 QTESGHKKLKSTIQ-RSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGA 1512
S K KS + R + +G + ++ + P R S GS + P R +
Sbjct: 764 ---SPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRT---PPRRSRS 817
Query: 1513 DSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGS--K 1570
S P++ + P ++ G ++G + +S+T + S +
Sbjct: 818 SSSPPPKQKSKTPSRQSHSSSSPHP---KVKSGTPPRQGSITSPQANEQSVTPQRRSCFE 874
Query: 1571 STPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVI 1622
S+P P +K +C R+ T +QS SPQ KV +I
Sbjct: 875 SSPDPELKSRTPSRHSCSGSSPPRVKSSTPP---RQSPSRSSSPQPKVKAII 923
Score = 47.4 bits (111), Expect = 1e-04
Identities = 77/356 (21%), Positives = 133/356 (37%), Gaps = 34/356 (9%)
Query: 206 REKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSRS 265
REK + R RS + ST+ + + R G+ ++ +Q SSR+ S
Sbjct: 1779 REKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRS---PARQESSRTSS 1835
Query: 266 EPPRERKKTPGLSEQNGKGAL------KSERKRVPKTSAQPVEGAVEERERKERRESRRL 319
R R +TP S + + +S + P T + R+ R + +
Sbjct: 1836 RRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPV 1895
Query: 320 EKGRSQDYPDTPEKRDEGKAA--DEEKQRKEEDYQTRYRS---DPNLARYPVKPPPEEQQ 374
+ RS+ +R +A+ + R TR RS P R P +
Sbjct: 1896 SRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTR 1955
Query: 375 MRMHAR---VSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARASPPDSPRAYS-- 429
R +R V+R R R S + R+ + + R + +R SP R+ S
Sbjct: 1956 RRSRSRTPPVTRRRSRSRTSPITRRRSRSRTS-----PVTRRRSRSRTSPVTRRRSRSRT 2010
Query: 430 ---AERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSR-LDPSSAVLMR 485
R + +R P A + + S R +P + ++ +R++SR P +A R
Sbjct: 2011 SPVTRRRSRSRTPPAIRRRSRS----RTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKR 2066
Query: 486 KAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTP 541
R +R S S S+ R + P R+ G + ++++SS S P
Sbjct: 2067 SLTRS--PPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRP 2120
Score = 47.0 bits (110), Expect = 2e-04
Identities = 59/268 (22%), Positives = 97/268 (36%), Gaps = 20/268 (7%)
Query: 187 TSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAE 246
TS+ + S T+ RSRS+TPL + S +P S RS+ +
Sbjct: 1847 TSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSV 1906
Query: 247 PSQQALGPEQKQASSRSRSEPP-----RERKKTPGLSEQNGKGALKSERKRVPKTSAQPV 301
+++ + RSRS P R R +TP ++ +S V + ++
Sbjct: 1907 TRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRS-----RSRTPPVTRRRSRSR 1961
Query: 302 EGAVEERERKERRESRRLEKGRSQDYPDTPEK-RDEGKAADEEKQRKEEDYQTRYRSDPN 360
V R + R + RS+ P T + R + R TR RS
Sbjct: 1962 TPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSR 2021
Query: 361 LARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARAS 420
PP ++ R + + R S +A+ R + + P GKR + R+
Sbjct: 2022 ------TPPAIRRRSRSRTPLLPRKRSRSRSPLAI-RRRSRSRTPRTARGKR--SLTRSP 2072
Query: 421 PPDSPRAYSAERTAETRAPGAKQLTNHS 448
P R+ S + +R+ NHS
Sbjct: 2073 PAIRRRSASGSSSDRSRSATPPATRNHS 2100
Score = 43.5 bits (101), Expect = 0.002
Identities = 77/367 (20%), Positives = 126/367 (34%), Gaps = 49/367 (13%)
Query: 1128 SPERERGRWSPSLDRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVL 1187
SPE + +P R P SP + + +P+ + R SS+ ++T T
Sbjct: 1483 SPEPKALPQTPRPRSRSPSSPELNNKCLTPQRE---RSGSESSVDQKTVART-------- 1531
Query: 1188 PTCLSRRGHAAPRATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRM 1247
P R ++ +P + + S SS S +T + GS+P +R+
Sbjct: 1532 PLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRL 1591
Query: 1248 HRQRSPTQSPPADTSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTG 1307
+RS + S P + R P+ S S + R + + + G
Sbjct: 1592 SPRRSRSGSSPE----VKDKPRAAPRAQSGSDSSPEPK---APAPRALPRRSRSGSSSKG 1644
Query: 1308 SGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSE 1367
G S E SS + SRT+ SS ++
Sbjct: 1645 RGPSPE-----------------------GSSSTESSPEHPPKSRTARRGSRSSPEPKTK 1681
Query: 1368 QSERPRGRISSFTPKMQGR-RMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAG 1426
PR R S +P++ + R+ RS S S S
Sbjct: 1682 SRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRS 1741
Query: 1427 GKKRRSSLSAKVVAIVSRRSRSTS------QLSQTESGHKKLKSTIQRSTETGMAAEMRK 1480
++RRS+ S + SRR RS S Q S++ S +K ++T +R + R+
Sbjct: 1742 SRRRRSASSPR-TKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR 1800
Query: 1481 MVRQPSR 1487
R SR
Sbjct: 1801 RQRSRSR 1807
Score = 41.6 bits (96), Expect = 0.007
Identities = 109/492 (22%), Positives = 170/492 (34%), Gaps = 76/492 (15%)
Query: 885 PRRHIHGESSSKKLQRSQRISDSDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQ 944
PRR G S S+ L R R S S G R+S R S+S + ++
Sbjct: 697 PRR---GRSRSRSLVRRGR-SHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKS 752
Query: 945 RTTHHRSRSVSPHRGNDQGK-------------PRSRLPNVPLQRSLDEIHPTRRSRSPT 991
R + RSRS+S R + + P+ + P + P +SR+P
Sbjct: 753 RISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPP 812
Query: 992 RHHDASRSPVDHRTRDVDSQYLSEQDSELLMLPRAKRGRSAECLHTTRHLVRHYKTLPPK 1051
R +S SP + S+ + S P+ K G T P +
Sbjct: 813 RRSRSSSSPPPKQKSKTPSR---QSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQR 869
Query: 1052 MPLLQSSSHWNIYSSILPAHTKTKSVTRQDISLHHECFNSTVLRFTDEILVSELQPFLDR 1111
+SS K+++ +R H C S+ R + S P
Sbjct: 870 RSCFESSP---------DPELKSRTPSR------HSCSGSSPPR-----VKSSTPPRQSP 909
Query: 1112 ARSASTNCLRPDTSLHSPERER---GRWSPSLDRRRPPSPRIQIQHASPENDRHSRKSER 1168
+RS+S +P R+R G SPS R + + + SP ++ SR R
Sbjct: 910 SRSSSP---QPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPR 966
Query: 1169 SSIQKQTRKGTASDAERVLPTCLSRRGHAA-----PRATDQ----PVIRG-KHPARSRSS 1218
S G++S +V P R+ H+ P+ Q P + G K P S
Sbjct: 967 YS-----HSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKS 1021
Query: 1219 EHSSIRTLCSMHHLVPG--GSAPP-------SPLLTRMHRQRSP-----TQSPPADTSFS 1264
+ S +++ L G S PP S L + Q SP T SP S S
Sbjct: 1022 KDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHS 1081
Query: 1265 SRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNI 1324
Q G ++S V E + ++ R + + + EQ S++
Sbjct: 1082 ESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQ-SRFQS 1140
Query: 1325 HKDQYRSCDNVS 1336
Y + D+ S
Sbjct: 1141 DSSSYPTVDSNS 1152
Score = 39.7 bits (91), Expect = 0.025
Identities = 74/359 (20%), Positives = 122/359 (33%), Gaps = 67/359 (18%)
Query: 212 LQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSRSEPPRER 271
L +R+RS+TP S + S + +P R G PSQ L P Q Q S S +
Sbjct: 2401 LLDRARSRTPPSAPSQSRMTSERAPSPSSRM-GQAPSQSLLPPAQDQPRSPVPSAFSDQS 2459
Query: 272 K-----KTPGLSEQN---------------GKGALKSERKRVP---------KTSAQPVE 302
+ TP Q+ G L VP T AQ
Sbjct: 2460 RCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPS 2519
Query: 303 GAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLA 362
+ KERR S S + + E + + L
Sbjct: 2520 ALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSD--SEGSSLPVQPEVALK 2577
Query: 363 RYPVKPPPEEQQMR--MHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARAS 420
R P P ++ +R + A+ +RR S + + +++ +S
Sbjct: 2578 RVPSPTPAPKEAVREGRPPEPTPAKRKRRSSS-------------SSSSSSSSSSSSSSS 2624
Query: 421 PPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSS 480
S + S+ ++ + + + + + P P+ P PA K P ++SR
Sbjct: 2625 SSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASP---KKPPPGERRSR----- 2676
Query: 481 AVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHR------SKRGGKKRQMSVSSS 533
+ R+ ++++ + SLS E RPSP R S+RG ++ Q S S
Sbjct: 2677 ------SPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRS 2729
Score = 37.7 bits (86), Expect = 0.095
Identities = 77/371 (20%), Positives = 123/371 (33%), Gaps = 60/371 (16%)
Query: 184 PQQTSQDGTLSD-----TATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSA- 237
P + S G++S T G + K QE+S+ S + S A S+
Sbjct: 984 PPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSST 1043
Query: 238 PPDRSKGAEPSQQALGPEQKQASSRSRSEPPRERK---KTPGLSEQNGKGALKSERKRVP 294
PP S S Q G Q RS + P R+ ++P L ++ + + K R R
Sbjct: 1044 PPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKS-QTSPKGGRSRSS 1102
Query: 295 KTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTR 354
+ + ++R E S L+ G S + Q+R
Sbjct: 1103 SPVTELASRSPIRQDRGEFSASPMLKSGMSPE-------------------------QSR 1137
Query: 355 YRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAP 414
++SD + P + + +R+ A + + +ALP E A P + K +P
Sbjct: 1138 FQSDSSSY-----PTVDSNSLLGQSRLETAESKEK---MALPPQEDATASPPRQKDKFSP 1189
Query: 415 AAARASPPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQS 474
+ P S RT PP R G +PE K Q S
Sbjct: 1190 FPVQDRPESSLVFKDTLRT---------------PPRERSGA--GSSPETKEQNSALPTS 1232
Query: 475 RLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSE 534
D ++ K++ + + S + S S S P+ S S +
Sbjct: 1233 SQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQAS 1292
Query: 535 EEGVSTPEYTS 545
E V P S
Sbjct: 1293 LEAVEVPSMAS 1303
Score = 37.4 bits (85), Expect = 0.12
Identities = 82/341 (24%), Positives = 115/341 (33%), Gaps = 70/341 (20%)
Query: 942 EQQRTTHHRSRSVSPHRGNDQGKPRSRLPNVPLQRSLDEIHPT--RRSRSPT----RHHD 995
E RT+ R R S + + RSR P +RS P RRSRS T R
Sbjct: 1829 ESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRS 1888
Query: 996 ASRSPVDHRTRDVDSQYLSEQDSELLMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLL 1055
SR+ R R ++ + S P ++R + TR R + P
Sbjct: 1889 RSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSR------SRTPTT 1942
Query: 1056 QSSSHWNIYSSILPAHTKTKSVTRQDISLHHECFNSTVLRFTDEILVSELQPFLDRARSA 1115
+ S S P T+ +S +R P + R RS
Sbjct: 1943 RRRSR-----SRTPPVTRRRSRSR--------------------------TPPVTRRRS- 1970
Query: 1116 STNCLRPDTSLHSPERERGRWSP-----SLDRRRPPSPRIQIQHASPENDRHSRKSERSS 1170
R TS + R R R SP S R P + R SP R SR +
Sbjct: 1971 -----RSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPA 2025
Query: 1171 IQKQTRKGT----ASDAERVLPTCLSRRGHA-APRAT--------DQPVIRGKHPARSRS 1217
I++++R T + P + RR + PR P IR + + S S
Sbjct: 2026 IRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSS 2085
Query: 1218 SEHSSIRTLCSMHHLVPGGSAPPSPL-LTRMHRQRSPTQSP 1257
S + +H G PP L +RM P+ SP
Sbjct: 2086 DRSRSATPPATRNH--SGSRTPPVALNSSRMSCFSRPSMSP 2124
Score = 36.2 bits (82), Expect = 0.28
Identities = 64/352 (18%), Positives = 124/352 (35%), Gaps = 33/352 (9%)
Query: 181 GSGPQQTSQDGTLSDTATGAGSEVPREK---KARLQERSRSQTPLSTAAASS-----QDA 232
G+ P+Q G+++ S P+ + ++ +S+TP + + S + +
Sbjct: 847 GTPPRQ----GSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSS 902
Query: 233 APPSAPPDRSKGAEPSQQA-LGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERK 291
PP P RS +P +A + P Q+ S S P R +T ++ E +
Sbjct: 903 TPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESR 962
Query: 292 RVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDY 351
+P+ S + + + K R+ G YP + G + K ++
Sbjct: 963 LLPRYSHS--GSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQE- 1019
Query: 352 QTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGK 411
+S +L V+ P + + S E +L P+ ++
Sbjct: 1020 ----KSKDSL----VQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDT 1071
Query: 412 RAPAAARASPPDSPRAYSAERTA-----ETRAPGAKQLTNHSPPAPRHGPVPAEAPELKA 466
+P R S +SP S +T+ + +L + SP G A
Sbjct: 1072 SSP-EVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSG 1130
Query: 467 QEPLRKQSRLDPSSAVLMRKAK---REKVETMLRNDSLSSDQSESVRPSPPK 515
P + + + D SS + + ++ET + ++ E SPP+
Sbjct: 1131 MSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPR 1182
Score = 35.4 bits (80), Expect = 0.47
Identities = 71/373 (19%), Positives = 125/373 (33%), Gaps = 38/373 (10%)
Query: 205 PREKKARLQERSRSQTPLSTAAAS-SQDAAPPSAP----PDRSKGAEPSQQALGPEQKQA 259
PR A + ++TP + AA S + PP+A R+ A S +GP A
Sbjct: 2287 PRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHA 2346
Query: 260 SSRSRSEPPR-----------ERKKTPGLSEQNGKGALKSERKRVPKTSAQPVEGAVEER 308
++ R + P LS N RVP ++ + V G
Sbjct: 2347 TAPVNIAGSRTAAALAPASLTSARMAPALSGAN------LTSPRVPLSAYERVSG----- 2395
Query: 309 ERKERRESRRLEKGRSQDYPDTPE--KRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPV 366
R L++ RS+ P P + +A + + Q+ + R PV
Sbjct: 2396 ----RTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPV 2451
Query: 367 KPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARASPPDSPR 426
+Q + A+ + + S A+ T + A G AP + + P
Sbjct: 2452 PSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPA 2511
Query: 427 AYSAERTAETRA--PGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSSAVLM 484
+ A++ + A P ++ ++ S + + + + S + SS +
Sbjct: 2512 STGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQ 2571
Query: 485 RKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYT 544
+ ++V + + RP P P + KR S SSS S+ +
Sbjct: 2572 PEVALKRVPSPT---PAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSS 2628
Query: 545 SCEDVELESESVS 557
S S S S
Sbjct: 2629 SSSSSSSSSSSSS 2641
Score = 35.0 bits (79), Expect = 0.62
Identities = 35/152 (23%), Positives = 49/152 (32%), Gaps = 5/152 (3%)
Query: 390 HSDVALPRTEAGAALPEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPGAKQLTNHSP 449
HSDV P GA P A + R+S S + S+ ++ + + + ++ S
Sbjct: 2503 HSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSD 2562
Query: 450 PAPRHGPVPAEAPELKAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESV 509
PV E + P P AV + R S SS S S
Sbjct: 2563 SEGSSLPVQPEVALKRVPSPTPA-----PKEAVREGRPPEPTPAKRKRRSSSSSSSSSSS 2617
Query: 510 RPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTP 541
S S S SSS S+P
Sbjct: 2618 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSP 2649
Score = 33.5 bits (75), Expect = 1.8
Identities = 92/475 (19%), Positives = 161/475 (33%), Gaps = 110/475 (23%)
Query: 184 PQQTSQDGTLSDTATGAGSEVPREKKARLQERSRSQT---PLSTAAASSQDAAPPSAPPD 240
P+Q SQ + +GS P+ K RSRS + P + S+ + S+P
Sbjct: 786 PKQKSQT---PPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHP 842
Query: 241 RSKGAEP-----------SQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSE 289
+ K P ++Q++ P+++ S S P + +TP +G + +
Sbjct: 843 KVKSGTPPRQGSITSPQANEQSVTPQRR--SCFESSPDPELKSRTPSRHSCSGSSPPRVK 900
Query: 290 RKRVPK------TSAQP-VEGAVEERERKERRESRRLEKGRSQDYPD------TPEKRDE 336
P+ +S QP V+ + R+R G S P TP +
Sbjct: 901 SSTPPRQSPSRSSSPQPKVKAIISPRQRS--------HSGSSSPSPSRVTSRTTPRRSRS 952
Query: 337 GKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALP 396
+ R Y S P+ P PP + HS P
Sbjct: 953 VSPCSNVESRLLPRYSHSGSSSPDTKVKPETPP-----------------RQSHSGSISP 995
Query: 397 RTEAGAALPEGK--AGKRAP---------------------AAARASPPDSPRAY----- 428
+ A P G +G ++P A ++S P +
Sbjct: 996 YPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSL 1055
Query: 429 --------SAERTAETRAPGAKQLTNHSP-------PAPRHGPVPAEAP--ELKAQEPLR 471
S + ++T +P +Q + SP +P+ G + +P EL ++ P+R
Sbjct: 1056 QLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIR 1115
Query: 472 KQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVS 531
+ SA M K+ ++ ++DS S +S S R + K +M++
Sbjct: 1116 QDR--GEFSASPMLKSGMSPEQSRFQSDSSSYPTVDS--NSLLGQSRLETAESKEKMALP 1171
Query: 532 SSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVT 586
E+ S P + + V ++ + + D RE S S P T
Sbjct: 1172 PQEDATASPPR----QKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPET 1222
Score = 33.5 bits (75), Expect = 1.8
Identities = 49/242 (20%), Positives = 78/242 (32%), Gaps = 29/242 (11%)
Query: 238 PPDRSKGAEPSQ-QALGP-EQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSER----- 290
PP + +PS AL P +++++SS S S + S + G+ S+
Sbjct: 2509 PPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSL 2568
Query: 291 --------KRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADE 342
KRVP + P E E R + R+ S + ++
Sbjct: 2569 PVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSS 2628
Query: 343 EKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGA 402
+ S + + P KP P+ + R S PR +
Sbjct: 2629 SSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRS----PRKPIDS 2684
Query: 403 ALPEGKAGKRAPAAARASPPDSPR---AYSAER------TAETRAPGAKQLTNHSPPAP- 452
R SP SPR + S+ER ++R+P K+ P P
Sbjct: 2685 LRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPM 2744
Query: 453 RH 454
RH
Sbjct: 2745 RH 2746
Score = 31.6 bits (70), Expect = 6.8
Identities = 30/135 (22%), Positives = 47/135 (34%), Gaps = 5/135 (3%)
Query: 182 SGPQQTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDR 241
S +S + S +++ + S + S S + S A Q P++P
Sbjct: 2609 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKP 2668
Query: 242 SKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQPV 301
G S+ P SRS S P ER++ + + SER S +
Sbjct: 2669 PPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSER-----GSRRGQ 2723
Query: 302 EGAVEERERKERRES 316
G K RRE+
Sbjct: 2724 RGDSRSPSHKRRRET 2738
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 65.9 bits (159), Expect = 3e-10
Identities = 35/125 (28%), Positives = 66/125 (52%), Gaps = 7/125 (5%)
Query: 758 QLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSH 817
+L V V A +L +PYVK+ +PD ++SK++TKT++ L P+WN++F +
Sbjct: 172 KLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFK- 230
Query: 818 VHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDES---S 874
+ ++R L + +WD R ++F+G + + + WYKL +E +
Sbjct: 231 -LKPSDKDRRLSVEIWDWDRT--TRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYN 287
Query: 875 LPLPQ 879
+P+P+
Sbjct: 288 VPIPE 292
Score = 50.1 bits (118), Expect = 2e-05
Identities = 42/126 (33%), Positives = 59/126 (46%), Gaps = 7/126 (5%)
Query: 1536 TPAMGDIQIGMEDKKGQLEVEVIRARSLT-QKPGSKSTPAPYVKVYLLENGACIAKKKTR 1594
T G I + E +L V V A++L P S P YVK+ L+ + +K+KT+
Sbjct: 156 TEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDP--YVKLKLIPDPKNESKQKTK 213
Query: 1595 IARKTLDPLYQQSLVFDESPQGK--VLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMV 1652
R TL+P + +S F P K L V +W D+ R FMG + EL +
Sbjct: 214 TIRSTLNPQWNESFTFKLKPSDKDRRLSVEIW-DWDRTTRNDFMGSLSFGVSEL-MKMPA 271
Query: 1653 IGWYKL 1658
GWYKL
Sbjct: 272 SGWYKL 277
>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
Length = 934
Score = 65.9 bits (159), Expect = 3e-10
Identities = 151/797 (18%), Positives = 290/797 (36%), Gaps = 151/797 (18%)
Query: 154 EDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQTSQDGTLSDTATGAGSEVPREKKARLQ 213
E++ V + + Q++ SG WF+ + ++ +D A R + A Q
Sbjct: 29 EEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKR-HRDKIHGADIIRASMRKKRPQIAAEQ 87
Query: 214 ERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSRSEPPRERKK 273
+ R + + A PP+ + E PE+ A + S
Sbjct: 88 SKDRENGAKESWVNNVNKDA--FLPPELAGVVEE------PEEDAAPASPSSSVVNPASS 139
Query: 274 TPGLSEQNG-KGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPE 332
+S++N K + E+++ P S++ EG ++ + E+ ++ R ++ + E
Sbjct: 140 VIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSE 199
Query: 333 KRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSD 392
+++ AD Q+ E+ QT
Sbjct: 200 SKEKSTVADTSIQKLEKSKQT--------------------------------------- 220
Query: 393 VALPRTEAGAAL--PEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPGAKQLTNHSPP 450
LP G+ + P KA K + + D+ +++ +RT +A GA
Sbjct: 221 --LPGLSNGSQIKAPIPKARKMIYKSTDLNKDDN-QSFPRQRTDSLKARGA--------- 268
Query: 451 APRHGPVPAEAPELKAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVR 510
PR + E LR +P S ++ + + + S + + S
Sbjct: 269 -PRGILKRNSSSSSTDSETLRYNHNFEPKSKIV---SPGLTIHERISEKEHSLEDNSSPN 324
Query: 511 PSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDP- 569
P H + K ++ S G E++ E L++ + + GD + + DP
Sbjct: 325 SLEPLKH-VRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKN-GMEDAGDTEEFQSDPK 382
Query: 570 -------ATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKR--TTMPKDSGALLGLKV 620
+ +H +SP S T QP G I + + T P+ +
Sbjct: 383 PSQYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINE 442
Query: 621 VGGKMTDLGRLGAFITKVKKGSLADVV---------GHLRAGDEVLEWNGKP-------- 663
K ++L RL + + + L+ V G R + E P
Sbjct: 443 PKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERS 502
Query: 664 ----LPGATNEEVYNIIL-ESKSEPQVEIIV--SRPIGDIPRIPES--SHPPL------- 707
+P + E++ + ++K + Q E +V + + +P P++ SHP
Sbjct: 503 AARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKS 562
Query: 708 ---------------ESSSSSFESQKMERPSISVISPTSPGALKDAPQV----------- 741
+S SS++ + ++ S+ + +S + V
Sbjct: 563 VPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGD 622
Query: 742 -----LPGQLSVKLWYDKVGHQLIVNVLQATDLPAR-VDGRPRNPYVKMYFLPDRSDKSK 795
+ G + + Y + +L V V Q DL A V + +PYVK Y LPD+ K
Sbjct: 623 FGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGK 682
Query: 796 RRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELET 855
++T VKK L P +N+ Y + ++ + + L +++W R + + FLGE+ ++LET
Sbjct: 683 KKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLSIWH--RDTFKRNSFLGEVELDLET 739
Query: 856 ALLDDEPH----WYKLQ 868
D++ + WY L+
Sbjct: 740 WDWDNKQNKQLRWYPLK 756
Score = 59.3 bits (142), Expect = 3e-08
Identities = 153/704 (21%), Positives = 249/704 (35%), Gaps = 126/704 (17%)
Query: 205 PREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSR 264
PR++ L+ R P +S ++ S + EP + + P S
Sbjct: 256 PRQRTDSLKARG---APRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHERISE 312
Query: 265 SEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQPVEGAVEERERKERR--ESRRLEKG 322
E E +P N LK R K G + RE E ES RL+ G
Sbjct: 313 KEHSLEDNSSP-----NSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNG 367
Query: 323 RSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVS 382
+D DT E + + K + Q ++ + S P +++ P ++ S
Sbjct: 368 M-EDAGDTEEFQSDPKPS----QYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGLHS 422
Query: 383 RARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPGAK 442
HS+V R ++ P K + PR+ A+ + P
Sbjct: 423 -------HSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRS-PADELSHCVEPEPS 474
Query: 443 QLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSSA---VLMRKAKREKVETMLRND 499
Q+ S + G +P LK E R +R PS + + + + KV+
Sbjct: 475 QVPGGSSRDRQQGSEEEPSPVLKTLE--RSAARKMPSKSLEDISSDSSNQAKVDNQPEEL 532
Query: 500 SLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEK 559
S++ +V P P K ++MS S P + E + E+++ SE
Sbjct: 533 VRSAEDVSTVPTQPDNPF--SHPDKLKRMSKS--------VPAFLQDESDDRETDTASES 582
Query: 560 G-DLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKDSGALLGL 618
L + P++ T+ SS +T S G + M SG L
Sbjct: 583 SYQLSRHKKSPSSL----TNLSSSSGMTSLSSVSG------------SVMSVYSGDFGNL 626
Query: 619 KVVGG------KMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEE- 671
+V G + L L F+ + K + ADV + D ++ P G ++
Sbjct: 627 EVKGNIQFAIEYVESLKELHVFVAQCKDLAAADV--KKQRSDPYVKAYLLPDKGKMGKKK 684
Query: 672 ----------VYNIILESKSEPQ-------------------------VEIIVSRPIGDI 696
VYN IL K E Q VE+ + D
Sbjct: 685 TLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDN 744
Query: 697 PRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQL-----SVKLW 751
+ + PL+ ++ + R + + AL+ P+ +PG+ V +W
Sbjct: 745 KQNKQLRWYPLKRKTAPVALEAENRGEMKL-------ALQYVPEPVPGKKLPTTGEVHIW 797
Query: 752 YDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQ 811
V + DLP + G N +VK LPD S KS+++T+ V K P +N
Sbjct: 798 -----------VKECLDLPL-LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNH 845
Query: 812 TFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELET 855
T VY D E +E+TVWD ++ ++FLG + I T
Sbjct: 846 TMVYDGFRPEDLMEACVELTVWDHYKL---TNQFLGGLRIGFGT 886
Score = 50.1 bits (118), Expect = 2e-05
Identities = 37/127 (29%), Positives = 59/127 (46%), Gaps = 9/127 (7%)
Query: 1540 GDIQIGME--DKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIAR 1597
G+IQ +E + +L V V + + L K PYVK YLL + + KKKT + +
Sbjct: 630 GNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVK 689
Query: 1598 KTLDPLYQQSLVFDESPQ---GKVLQVIVWGDYGRMDHKCFMGVAQILLEELD---LSSM 1651
KTL+P+Y + L + Q + L + +W F+G ++ LE D +
Sbjct: 690 KTLNPVYNEILRYKIEKQILKTQKLNLSIW-HRDTFKRNSFLGEVELDLETWDWDNKQNK 748
Query: 1652 VIGWYKL 1658
+ WY L
Sbjct: 749 QLRWYPL 755
Score = 31.2 bits (69), Expect = 8.9
Identities = 21/95 (22%), Positives = 46/95 (48%), Gaps = 17/95 (17%)
Query: 1537 PAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIA 1596
P G++ I +++ L++ ++R L +VK +L + + +++KTR
Sbjct: 789 PTTGEVHIWVKEC---LDLPLLRGSHLNS----------FVKCTILPDTSRKSRQKTRAV 835
Query: 1597 RKTLDPLYQQSLVFD----ESPQGKVLQVIVWGDY 1627
KT +P++ ++V+D E +++ VW Y
Sbjct: 836 GKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHY 870
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,536,806
Number of Sequences: 37866
Number of extensions: 3762672
Number of successful extensions: 27111
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 277
Number of HSP's successfully gapped in prelim test: 1191
Number of HSP's that attempted gapping in prelim test: 18658
Number of HSP's gapped (non-prelim): 7489
length of query: 1692
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1576
effective length of database: 13,855,062
effective search space: 21835577712
effective search space used: 21835577712
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.