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Search of human proteins with 40548415
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40548415 dishevelled associated activator of morphogenesis 2
[Homo sapiens]
(1067 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 2127 0.0
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 1439 0.0
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 392 e-109
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 387 e-107
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 386 e-107
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 358 1e-98
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 356 7e-98
gi|52485606 formin-like 2 [Homo sapiens] 331 3e-90
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 328 2e-89
gi|33356148 formin-like 1 [Homo sapiens] 317 3e-86
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 290 5e-78
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 290 5e-78
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 263 7e-70
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 263 7e-70
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 200 5e-51
gi|145309324 FH2 domain containing 1 [Homo sapiens] 187 5e-47
gi|157168329 formin 1 [Homo sapiens] 184 5e-46
gi|160707881 formin 2 [Homo sapiens] 168 2e-41
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 129 2e-29
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 127 7e-29
gi|14249316 hypothetical protein LOC84800 [Homo sapiens] 87 6e-17
gi|56549694 enabled homolog isoform a [Homo sapiens] 77 7e-14
gi|39930375 enabled homolog isoform b [Homo sapiens] 77 7e-14
gi|126090663 zinc finger homeodomain 4 [Homo sapiens] 62 3e-09
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens] 59 2e-08
gi|39812378 RAN binding protein 9 [Homo sapiens] 58 5e-08
gi|150170670 piccolo isoform 2 [Homo sapiens] 58 5e-08
gi|150378539 piccolo isoform 1 [Homo sapiens] 58 5e-08
gi|210032580 SET domain containing 1B [Homo sapiens] 58 5e-08
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 57 7e-08
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 2127 bits (5511), Expect = 0.0
Identities = 1067/1067 (100%), Positives = 1067/1067 (100%)
Query: 1 MAPRKRSHHGLGFLCCFGGSDIPEINLRDNHPLQFMEFSSPIPNAEELNIRFAELVDELD 60
MAPRKRSHHGLGFLCCFGGSDIPEINLRDNHPLQFMEFSSPIPNAEELNIRFAELVDELD
Sbjct: 1 MAPRKRSHHGLGFLCCFGGSDIPEINLRDNHPLQFMEFSSPIPNAEELNIRFAELVDELD 60
Query: 61 LTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDE 120
LTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDE
Sbjct: 61 LTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDE 120
Query: 121 EETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGC 180
EETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGC
Sbjct: 121 EETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGC 180
Query: 181 IKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAM 240
IKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAM
Sbjct: 181 IKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAM 240
Query: 241 LHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHL 300
LHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHL
Sbjct: 241 LHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHL 300
Query: 301 RYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMF 360
RYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMF
Sbjct: 301 RYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMF 360
Query: 361 ELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDL 420
ELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDL
Sbjct: 361 ELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDL 420
Query: 421 APLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMM 480
APLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMM
Sbjct: 421 APLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMM 480
Query: 481 RTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDL 540
RTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDL
Sbjct: 481 RTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDL 540
Query: 541 PPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQ 600
PPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQ
Sbjct: 541 PPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQ 600
Query: 601 PSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDI 660
PSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDI
Sbjct: 601 PSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDI 660
Query: 661 YLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFI 720
YLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFI
Sbjct: 661 YLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFI 720
Query: 721 PEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVE 780
PEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVE
Sbjct: 721 PEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVE 780
Query: 781 AILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNIS 840
AILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNIS
Sbjct: 781 AILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNIS 840
Query: 841 LLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQ 900
LLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQ
Sbjct: 841 LLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQ 900
Query: 901 VREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIF 960
VREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIF
Sbjct: 901 VREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIF 960
Query: 961 DTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGG 1020
DTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGG
Sbjct: 961 DTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGG 1020
Query: 1021 EFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEVTRERAINRLNY 1067
EFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEVTRERAINRLNY
Sbjct: 1021 EFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEVTRERAINRLNY 1067
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 1439 bits (3724), Expect = 0.0
Identities = 736/1090 (67%), Positives = 882/1090 (80%), Gaps = 35/1090 (3%)
Query: 1 MAPRKRSHHGLGFL-CCFGGSDIPEINLR----DNHPLQFMEFSSPIPNAEELNIRFAEL 55
MAPRKR G+ F+ CCF +D PEI R N LQ ME + P+P EEL++ F+EL
Sbjct: 1 MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSEL 60
Query: 56 VDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSL 115
VDELDLTDK+REAMFALP EKKWQIYCSKKK+QE+ NK ATSWP++YID++NSMAA +SL
Sbjct: 61 VDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEE-NKGATSWPEFYIDQLNSMAARKSL 119
Query: 116 YAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHT 175
A ++EE E R++ +E LKTALRT+PMRFVTRFI+L+GL+C+LNFL++MD+ T ESRIHT
Sbjct: 120 LALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHT 179
Query: 176 SLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKK 235
SLIGCIKALMNNSQGRAHVLA E+I+ IAQSL TEN KTKVAVLEILGAVCLVPGGHKK
Sbjct: 180 SLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKK 239
Query: 236 VLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLE 295
VLQAMLHYQ YA+ERTRFQTL+N+LD+S GRYRDEV+LKTAIMSFINAVL+ GAG ++L+
Sbjct: 240 VLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLD 299
Query: 296 FRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKS 355
FRLHLRYEFLMLGIQPVIDKLR+HEN+ LD+HLDFFEM+RNED+LE A+RF++VHIDTKS
Sbjct: 300 FRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKS 359
Query: 356 ASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERG 415
A+QMFEL K+L ++EAYP +S+LHHCLQMPYKR+G Q W LLDRI+QQIV+Q+++G
Sbjct: 360 ATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKG 419
Query: 416 VDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLE 475
DPD PLENFN+KN+V ML+NENEVKQW++QAEK RKEH EL +LE+KEREC+ KT E
Sbjct: 420 QDPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQE 479
Query: 476 KEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPV-------SSPPPPGGP 528
KEEMM+TLNKMK+KL +E+ E +Q + QVA+L AQL ELS V SP PGGP
Sbjct: 480 KEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGP 539
Query: 529 LTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPS 588
SS+ + LPPPPPP PPPPPPLPPGGPP PPG PP LG +P P P
Sbjct: 540 --FPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPP-LGAIMPPPGAP--- 593
Query: 589 SDVPLRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQ 648
+ L+KK +PQP++ LKSFNW KL E ++ GTVW EIDD +VF+ILDLED E+ FSAYQ
Sbjct: 594 MGLALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQ 653
Query: 649 RH----------QKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQA 698
R QKE + +D + KVKELSVIDGRRAQNC ILLS+LKLSN+EI++A
Sbjct: 654 RQQDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRA 713
Query: 699 ILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQR 758
IL MDEQEDL KDMLEQLLKF+PEKSDIDLLEEHKHE++RMA+ADRFL+EMSRI+HYQQR
Sbjct: 714 ILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQR 773
Query: 759 LQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAY 818
LQ+L+FKKKF ER+AE KPKVEAI S E+ RS L+Q+LEV+LA GN+MNKGQRG AY
Sbjct: 774 LQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAY 833
Query: 819 GFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELE 878
GF+++SLNKIADTKSSID+NI+LLHYLI I+E +P +LN+ EL+ +P+AAKVN+ EL+
Sbjct: 834 GFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELD 893
Query: 879 KEVGNLRRGLRAVEV-LEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKF 937
KE+ LR GL+AVE LEYQ+ Q +P DKFV V+S FITV+SFSFS++ED L EA+D F
Sbjct: 894 KEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLF 953
Query: 938 AKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQ 997
KA+ HFGE K+QPDEFFGIFD FLQA SEA+Q+ E MR++KEEEERRARMEA LKEQ
Sbjct: 954 TKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQ 1013
Query: 998 RERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEVT 1057
RERER R+ K + EE GEFDDLVSALRSGEVFDKDL KLKR+RKR +Q + +
Sbjct: 1014 RERERKMRKAK-----ENSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSS 1068
Query: 1058 RERAINRLNY 1067
RER I +LN+
Sbjct: 1069 RERPITKLNF 1078
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 392 bits (1007), Expect = e-109
Identities = 291/1034 (28%), Positives = 521/1034 (50%), Gaps = 94/1034 (9%)
Query: 32 PLQFME-FSSPIPNAEELNIRFAELVDELDLTDKN----REAMFALPPEKKWQIYCSKKK 86
PL+ ME F P+ E L + F +++++++L + RE F++ E Q Y +
Sbjct: 106 PLEMMENFPKPLSENELLEL-FEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQ-YINTAS 163
Query: 87 EQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVT 146
+ + P +I + +A + L +E L+ +L + P+ +V
Sbjct: 164 KTGSLKRSRQISPQEFIHELKMGSADERLVT-----------CLESLRVSLTSNPVSWVE 212
Query: 147 RFIELEGLTCLLNFLRSMDHATCESRI----HTSLIGCIKALMNNSQGRAHVLAQPEAIS 202
F EGL LL+ L + + ++ +I C+KALMN G ++++ ++S
Sbjct: 213 SFGH-EGLGLLLDILEKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLS 271
Query: 203 TIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDR 262
+A+++ + V+++L AVC+V G + +L+ +L A E + ++
Sbjct: 272 LLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKIDRFFCIVE- 328
Query: 263 SLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENA 322
G + V L+ A M INA++ + D+L+FRLH+R EF+ G++ ++ L+ +N
Sbjct: 329 --GLRHNSVQLQVACMQLINALVTS---PDDLDFRLHIRNEFMRCGLKEILPNLKCIKND 383
Query: 323 ILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLSVLHH 382
LD L F+ + ED EL+ R + + + A ++ ++ +K T A +S+L H
Sbjct: 384 GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH 443
Query: 383 CLQMPYKRNGGYFQQ--WQLLDRILQQIVLQDERGVDPDLAPLE--NFNVKNIVNMLINE 438
L + RN + +Q ++L+D + QIVL + G+DPD + + ++ V++ I++
Sbjct: 444 LLLI---RNDYFIRQQYFKLIDECVSQIVLHRD-GMDPDFTYRKRLDLDLTQFVDICIDQ 499
Query: 439 NEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELR 498
+++++ ++A + K+ E + + +E L K + K+ EL+
Sbjct: 500 AKLEEFEEKASELYKKF--------------EKEFTDHQETQAELQKKEAKINELQAELQ 545
Query: 499 QARGQVAELVAQLS-------ELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFAC 551
+ Q L A + E TG + PPPP P + +PPPPPP
Sbjct: 546 AFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLP-------SGGGVPPPPPP----- 593
Query: 552 CPPPPPPPLP----PGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQPSHPLKS 607
PPPPPLP P P PP PP LG P P L+ K+ +P ++
Sbjct: 594 ---PPPPPLPGMRMPFSGPVPP--PPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRR 648
Query: 608 FNWVKLN-EERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYLASRK 666
NW+K+ E W ++++ + + L E F Q+ ++E E+ +K
Sbjct: 649 LNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKK 708
Query: 667 VKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDI 726
+KEL +D + AQN I LS ++ EEIR IL++DE LA+ M++ L+K +P++ +
Sbjct: 709 IKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETR-LAESMIQNLIKHLPDQEQL 767
Query: 727 DLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLAS 786
+ L + K E + ++F+ MS + + RL A+ FK +F+E++ KP + A+ A
Sbjct: 768 NSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTAC 827
Query: 787 RELVRSKRLRQMLEVILAIGNFMNKGQRGG-AYGFRVASLNKIADTKSSIDRNISLLHYL 845
E+ +SK ++LE++L +GN+MN G R +GF ++SL K+ DTKS+ D+ +LLH+L
Sbjct: 828 EEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSA-DQKTTLLHFL 886
Query: 846 IMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQVREPS 905
+ I E+ +PDILN +L+ L +A+KV++ LEK NLR+ R ++ LE + P
Sbjct: 887 VEICEEKYPDILNFVDDLEPLDKASKVSVETLEK---NLRQMGRQLQQLEKELETFPPPE 943
Query: 906 ---DKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHD-SKMQPDEFFGIFD 961
DKFV MS F+ +S+ E +L+E +K ++++ + D K+ ++F +
Sbjct: 944 DLHDKFVTKMSRFV-ISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLN 1002
Query: 962 TFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGE 1021
F F +A ++ +R EE+E+R R+ L E+ ER Q+++++L + +E G
Sbjct: 1003 NFRTTFMQAIKE-NIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGV 1061
Query: 1022 FDDLVSALRSGEVF 1035
D+L+ AL+SG F
Sbjct: 1062 MDNLLEALQSGAAF 1075
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 387 bits (993), Expect = e-107
Identities = 314/1086 (28%), Positives = 532/1086 (48%), Gaps = 136/1086 (12%)
Query: 31 HPLQ----FMEFSSPIPNAEELNIRFAELVDELDLTDKNREAMFALPPEKKWQIYCSKKK 86
HP+ EF + P +E ++ +E + LDL +K E M L EKK +
Sbjct: 76 HPIDSQVAMSEFPAAQPLYDERSLNLSEK-EVLDLFEKMMEDM-NLNEEKKAPLR----- 128
Query: 87 EQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEET--------EMRNQV--------V 130
NK T+ + + I++ A L E T E+R+ + +
Sbjct: 129 -----NKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLLNCL 183
Query: 131 EDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSM----DHATCESRIHTSLIGCIKALMN 186
E L+ +L + P+ +V F EGL LL+ L + + + LI C+KA MN
Sbjct: 184 ESLRVSLTSNPVSWVNNFGH-EGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMN 242
Query: 187 NSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVY 246
N G +L ++ +A+++ + +++IL A+C+V G + +L +L
Sbjct: 243 NKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIV--GEENILDKLLGAITT 300
Query: 247 AAERT---RFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYE 303
AAER RF ++ L+ ++ + L+ A M FINA++ + L+FR+HLR E
Sbjct: 301 AAERNNRERFSPIVEGLEN-----QEALQLQVACMQFINALVTSPY---ELDFRIHLRNE 352
Query: 304 FLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELI 363
FL G++ ++ L++ EN LD L F+ + +D EL+ R + + + ++++ L+
Sbjct: 353 FLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLL 412
Query: 364 HKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYF--QQWQLLDRILQQIVLQDERGVDPDLA 421
+ LK T A LS+L H L + RN Y Q +++++ + QIVL G+DPD
Sbjct: 413 YNMLKDTAAENYFLSILQHFLLI---RNDYYIRPQYYKIIEECVSQIVLHCS-GMDPDFK 468
Query: 422 PLENFNVK--NIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEM 479
+ ++ ++++ +N+ +V++ +A +F K+ E + ++E
Sbjct: 469 YRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDE--------------EFTARQEA 514
Query: 480 MRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSP--------PPPGGPLTL 531
L K +K+ E++Q R Q A++++ S + P + P PPP PL
Sbjct: 515 QAELQKRDEKIKELEAEIQQLRTQ-AQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPG 573
Query: 532 SSSMTTNDLPPPPPPLP-FACCPPPPPPPLPPGGPPTPP---GAPPCLGMGLPLPQDPYP 587
+ LPPPPPPLP PPPPPPPL GGPP PP G PP G+ L LP
Sbjct: 574 GAP-----LPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYG--- 625
Query: 588 SSDVPLRKKRVPQPSHPLKSFNWVKLNE-ERVPGTVWNEIDDMQVFRILDLEDFEKM--- 643
+++K++ +P +K NW K+ E W + + + F DL F K+
Sbjct: 626 -----MKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDK-FENPDL--FAKLALN 677
Query: 644 FSAYQRHQKELGSTEDIYLA--SRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILK 701
F+ + QK + E+ +KVKEL ++D + AQN I L ++ E+IR IL+
Sbjct: 678 FATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILE 737
Query: 702 MDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQA 761
++E + L++ +++ L+K +PE+ ++ L E K+E + + ++F MS + Q RL +
Sbjct: 738 VNE-DMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSS 796
Query: 762 LFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGG-AYGF 820
+ FK F+E + KP + A+ LA EL +S+ ++LE++L +GN+MN G R + GF
Sbjct: 797 ILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGF 856
Query: 821 RVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKV-------N 873
++ L KI DTKS+ D+ +LLH++ I E+ + DIL P EL+H+ A+KV N
Sbjct: 857 KINFLCKIRDTKSA-DQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSN 915
Query: 874 LAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEA 933
LA +E+++ +L R ++ E Q DKFV M+ F + + +L N
Sbjct: 916 LASMEQQIVHLERDIKKFPQAENQH-------DKFVEKMTSFTKTAREQYEKLSTMHNNM 968
Query: 934 RDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAM 993
+ +F + +EFFG + F F EA ++ RR EE+ RRA++
Sbjct: 969 MKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRE-NNKRREMEEKTRRAKLAKE 1027
Query: 994 LKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVF-----------DKDLCKL 1042
EQ + ER +++++++ +E G D+L+ AL+SG F D L
Sbjct: 1028 KAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNPDNRRVPL 1087
Query: 1043 KRSRKR 1048
+RSR R
Sbjct: 1088 ERSRSR 1093
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 386 bits (991), Expect = e-107
Identities = 308/1062 (29%), Positives = 525/1062 (49%), Gaps = 125/1062 (11%)
Query: 31 HPLQ----FMEFSSPIPNAEELNIRFAELVDELDLTDKNREAMFALPPEKKWQIYCSKKK 86
HP+ EF + P +E ++ +E + LDL +K E M L EKK +
Sbjct: 76 HPIDSQVAMSEFPAAQPLYDERSLNLSEK-EVLDLFEKMMEDM-NLNEEKKAPLR----- 128
Query: 87 EQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEET--------EMRNQV--------V 130
NK T+ + + I++ A L E T E+R+ + +
Sbjct: 129 -----NKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLLNCL 183
Query: 131 EDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSM----DHATCESRIHTSLIGCIKALMN 186
E L+ +L + P+ +V F EGL LL+ L + + + LI C+KA MN
Sbjct: 184 ESLRVSLTSNPVSWVNNFGH-EGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMN 242
Query: 187 NSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVY 246
N G +L ++ +A+++ + +++IL A+C+V G + +L +L
Sbjct: 243 NKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIV--GEENILDKLLGAITT 300
Query: 247 AAERT---RFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYE 303
AAER RF ++ L+ ++ + L+ A M FINA++ + L+FR+HLR E
Sbjct: 301 AAERNNRERFSPIVEGLEN-----QEALQLQVACMQFINALVTSPY---ELDFRIHLRNE 352
Query: 304 FLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELI 363
FL G++ ++ L++ EN LD L F+ + +D EL+ R + + + ++++ L+
Sbjct: 353 FLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLL 412
Query: 364 HKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYF--QQWQLLDRILQQIVLQDERGVDPDLA 421
+ LK T A LS+L H L + RN Y Q +++++ + QIVL G+DPD
Sbjct: 413 YNMLKDTAAENYFLSILQHFLLI---RNDYYIRPQYYKIIEECVSQIVLHCS-GMDPDFK 468
Query: 422 PLENFNVK--NIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEM 479
+ ++ ++++ +N+ +V++ +A +F K+ E + ++E
Sbjct: 469 YRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDE--------------EFTARQEA 514
Query: 480 MRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSP--------PPPGGPLTL 531
L K +K+ E++Q R Q A++++ S + P + P PPP PL
Sbjct: 515 QAELQKRDEKIKELEAEIQQLRTQ-AQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPG 573
Query: 532 SSSMTTNDLPPPPPPLP-FACCPPPPPPPLPPGGPPTPP---GAPPCLGMGLPLPQDPYP 587
+ LPPPPPPLP PPPPPPPL GGPP PP G PP G+ L LP
Sbjct: 574 GAP-----LPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYG--- 625
Query: 588 SSDVPLRKKRVPQPSHPLKSFNWVKLNE-ERVPGTVWNEIDDMQVFRILDLEDFEKM--- 643
+++K++ +P +K NW K+ E W + + + F DL F K+
Sbjct: 626 -----MKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDK-FENPDL--FAKLALN 677
Query: 644 FSAYQRHQKELGSTEDIYLA--SRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILK 701
F+ + QK + E+ +KVKEL ++D + AQN I L ++ E+IR IL+
Sbjct: 678 FATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILE 737
Query: 702 MDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQA 761
++E + L++ +++ L+K +PE+ ++ L E K+E + + ++F MS + Q RL +
Sbjct: 738 VNE-DMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSS 796
Query: 762 LFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGG-AYGF 820
+ FK F+E + KP + A+ LA EL +S+ ++LE++L +GN+MN G R + GF
Sbjct: 797 ILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGF 856
Query: 821 RVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKV-------N 873
++ L KI DTKS+ D+ +LLH++ I E+ + DIL P EL+H+ A+KV N
Sbjct: 857 KINFLCKIRDTKSA-DQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSN 915
Query: 874 LAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEA 933
LA +E+++ +L R ++ E Q DKFV M+ F + + +L N
Sbjct: 916 LASMEQQIVHLERDIKKFPQAENQH-------DKFVEKMTSFTKTAREQYEKLSTMHNNM 968
Query: 934 RDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAM 993
+ +F + +EFFG + F F EA ++ RR EE+ RRA++
Sbjct: 969 MKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRE-NNKRREMEEKTRRAKLAKE 1027
Query: 994 LKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVF 1035
EQ + ER +++++++ +E G D+L+ AL+SG F
Sbjct: 1028 KAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAF 1069
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 358 bits (920), Expect = 1e-98
Identities = 251/862 (29%), Positives = 447/862 (51%), Gaps = 71/862 (8%)
Query: 195 LAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQ 254
+++ ++S +A+++ + V+++L AVC+V G + +L+ +L A E +
Sbjct: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKID 58
Query: 255 TLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVID 314
++ G + V L+ A M INA++ + D+L+FRLH+R EF+ G++ ++
Sbjct: 59 RFFCIVE---GLRHNSVQLQVACMQLINALVTS---PDDLDFRLHIRNEFMRCGLKEILP 112
Query: 315 KLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYP 374
L+ +N LD L F+ + ED EL+ R + + + A ++ ++ +K T A
Sbjct: 113 NLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEG 172
Query: 375 CLLSVLHHCLQMPYKRNGGYFQQ--WQLLDRILQQIVLQDERGVDPDLAPLE--NFNVKN 430
+S+L H L + RN + +Q ++L+D + QIVL + G+DPD + + ++
Sbjct: 173 YFISILQHLLLI---RNDYFIRQQYFKLIDECVSQIVLHRD-GMDPDFTYRKRLDLDLTQ 228
Query: 431 IVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKL 490
V++ I++ +++++ ++A + K+ E + + +E L K + K+
Sbjct: 229 FVDICIDQAKLEEFEEKASELYKKF--------------EKEFTDHQETQAELQKKEAKI 274
Query: 491 ARESQELRQARGQVAELVAQLS-------ELSTGPVSSPPPPGGPLTLSSSMTTNDLPPP 543
EL+ + Q L A + E TG + PPPP P + +PPP
Sbjct: 275 NELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLP-------SGGGVPPP 327
Query: 544 PPPLPFACCPPPPPPPLP----PGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVP 599
PPP PPPPPLP P P PP PP LG P P L+ K+
Sbjct: 328 PPP--------PPPPPLPGMRMPFSGPVPP--PPPLGFLGGQNSPPLPILPFGLKPKKEF 377
Query: 600 QPSHPLKSFNWVKLN-EERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTE 658
+P ++ NW+K+ E W ++++ + + L E F Q+ ++E E
Sbjct: 378 KPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIE 437
Query: 659 DIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLK 718
+ +K+KEL +D + AQN I LS ++ EEIR IL++DE LA+ M++ L+K
Sbjct: 438 EKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETR-LAESMIQNLIK 496
Query: 719 FIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPK 778
+P++ ++ L + K E + ++F+ MS + + RL A+ FK +F+E++ KP
Sbjct: 497 HLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPD 556
Query: 779 VEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGG-AYGFRVASLNKIADTKSSIDR 837
+ A+ A E+ +SK ++LE++L +GN+MN G R +GF ++SL K+ DTKS+ D+
Sbjct: 557 IMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSA-DQ 615
Query: 838 NISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQ 897
+LLH+L+ I E+ +PDILN +L+ L +A+KV++ LEK NLR+ R ++ LE +
Sbjct: 616 KTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEK---NLRQMGRQLQQLEKE 672
Query: 898 RRQVREPS---DKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHD-SKMQP 953
P DKFV MS F+ +S+ E +L+E +K ++++ + D K+
Sbjct: 673 LETFPPPEDLHDKFVTKMSRFV-ISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSV 731
Query: 954 DEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAG 1013
++F + F F +A ++ +R EE+E+R R+ L E+ ER Q+++++L
Sbjct: 732 EDFLTDLNNFRTTFMQAIKE-NIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMK 790
Query: 1014 SSLEEGGEFDDLVSALRSGEVF 1035
+ +E G D+L+ AL+SG F
Sbjct: 791 TEGDETGVMDNLLEALQSGAAF 812
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 356 bits (913), Expect = 7e-98
Identities = 282/1023 (27%), Positives = 481/1023 (47%), Gaps = 165/1023 (16%)
Query: 32 PLQFMEFSSPIPNAEELNIRFAELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDP 91
PL P+P EL RFA ++ ++L + EKKW + C +++ Q
Sbjct: 18 PLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQ--- 74
Query: 92 NKLATSWPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFI-- 149
+ P YI ++ S + +V+ +L+ +LRT + +V F+
Sbjct: 75 ---VKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLND 131
Query: 150 ELEGLTCLLNFLR----SMDHATCESR--------------IHTSLIGCIKALMNNSQGR 191
E +GL L+++L S+ ++T R +H ++ C++A+MN G
Sbjct: 132 ENKGLDVLVDYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCIL-CLRAIMNYQYGF 190
Query: 192 AHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERT 251
V++ P A++ IA SL +N +TK VLE+L AVCLV GGH+ +L A +++ E
Sbjct: 191 NLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELH 250
Query: 252 RFQTLLNELDRSLGRYRDE---VNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLG 308
RF+ L+ +R+E ++ A M FIN V+++ +++ FR+HL+YEF LG
Sbjct: 251 RFEKLME-------YFRNEDSNIDFMVACMQFINIVVHS---VEDMNFRVHLQYEFTKLG 300
Query: 309 IQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLK 368
++ + K R E+ L + + L FD+
Sbjct: 301 LEEFLQKSRHTESEKLQVQIQAY----------LDNVFDV-------------------- 330
Query: 369 YTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDER--GVDPDLAPLENF 426
GG + + + L+++ +E + L LEN
Sbjct: 331 -----------------------GGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENE 367
Query: 427 NVKNIV----NMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRT 482
N+ + +L E E++ ++ E + + RL +++ E + E +R
Sbjct: 368 NMMRVAELEKQLLQREKELESIKETYEN-TSHQVHTLRRLIKEKEEAFQRRCHLEPNVRG 426
Query: 483 LNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDLPP 542
L + +S+ L AR AEL + ++ PPP L L PP
Sbjct: 427 LESV------DSEAL--ARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLP--------PP 470
Query: 543 PPPPLPFACCPPPPPPPLPPGGPPTP--PGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQ 600
P PPL PPPPPPLP PP P PGA P + + + L +R K+ +
Sbjct: 471 PAPPL------PPPPPPLPDKCPPAPPLPGAAPSVVLTVGLS---------AIRIKKPIK 515
Query: 601 PSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDI 660
L FNW L ++ GTV++E+DD ++ LDL+ FE++F K G D+
Sbjct: 516 TKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKT-----KAQGPALDL 570
Query: 661 YLASRK-----VKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQ 715
+ K ++++++ RA+N I L K S EEI +AI D Q L D +E
Sbjct: 571 ICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQ-TLPVDFVEC 629
Query: 716 LLKFIPEKSDIDLLEEHKHE---IERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERL 772
L++F+P ++++ LL +++ E +E +A DRF+ S+++ QR+ + F FQ+ L
Sbjct: 630 LMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNL 689
Query: 773 AEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTK 832
P++ AI+ AS + S++L+QMLE+ILA+GN+MN +RG YGF++ SL+ + DTK
Sbjct: 690 QMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTK 749
Query: 833 SSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVE 892
S+ DR ++LLH++ + +++ +PD+ N EL + +AA V+L + +V L RG+ +
Sbjct: 750 ST-DRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIR 808
Query: 893 VLEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQ 952
RE S V+ +F++ + +L+ A + + + +FGE
Sbjct: 809 ---------RECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTP 859
Query: 953 PDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAM------LKEQRERERWQRQ 1006
P FF +F F++++ EA Q+ EA R+K+EE R + A K +R +WQ+Q
Sbjct: 860 PSVFFPVFVRFIRSYKEAEQENEA--RKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQ 917
Query: 1007 RKV 1009
+
Sbjct: 918 ELI 920
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 331 bits (848), Expect = 3e-90
Identities = 253/902 (28%), Positives = 452/902 (50%), Gaps = 114/902 (12%)
Query: 178 IGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVL 237
I C++A+MN G V++ P A++ IA SL +N +TK VLE+L AVCLV GGH+ +L
Sbjct: 225 IMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIIL 284
Query: 238 QAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFR 297
A +++ E+ RF+ L+ + ++ A M FIN V+++ +++ FR
Sbjct: 285 SAFDNFKEVCGEKQRFEKLMEHFRNE----DNNIDFMVASMQFINIVVHS---VEDMNFR 337
Query: 298 LHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHI--DTKS 355
+HL+YEF LG+ +DKL+ E+ L + + L FD+ + D ++
Sbjct: 338 VHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAY----------LDNVFDVGALLEDAET 387
Query: 356 ASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERG 415
+ E + + + ++ H ++ N + +L +++Q+ E
Sbjct: 388 KNAALERVEELEE---------NISHLSEKLQDTENEAMSKIVELEKQLMQR---NKELD 435
Query: 416 VDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLE 475
V ++ N V + M+ K ++E ++ S LE+K E LE
Sbjct: 436 VVREIYKDANTQVHTLRKMV--------------KEKEEAIQRQSTLEKKIHE-----LE 476
Query: 476 KEEMMRTLNKMKDKLARESQELRQARGQVAELVA------QLSELSTGPVSSPPPP---- 525
K+ ++ K +A +E+VA + S+GP+ PPPP
Sbjct: 477 KQGTIKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPS 536
Query: 526 -GGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGP-----PTPPGAPPCLGMGL 579
P T+ + T +PPPPPP P PPPPPPP P GP P PP APP L
Sbjct: 537 SDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPP-LPSAP 595
Query: 580 PLPQDPYP-----SSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRI 634
PLP P S ++ K+ + + FNWV L ++ GTV+NEIDD ++
Sbjct: 596 PLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILED 655
Query: 635 LDLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKE-----LSVIDGRRAQNCIILLSKLK 689
L++++FE++F K G D+ + +K+ + +++++ RA+N I L K
Sbjct: 656 LNVDEFEEIFKT-----KAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAG 710
Query: 690 LSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHE---IERMARADRFL 746
+ +EI +AI D + L D +E L++F+P ++++ +L ++ E +E ++ DRF+
Sbjct: 711 KTADEICKAIHVFD-LKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFM 769
Query: 747 YEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIG 806
+ S+I+ Q++ + F F E + P++ AI+ AS + S++L+++LE+ILA+G
Sbjct: 770 MQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALG 829
Query: 807 NFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHL 866
N+MN +RG YGF++ SL+ + DTKS+ DR +LLHY+ ++++ + + +EL ++
Sbjct: 830 NYMNSSKRGAVYGFKLQSLDLLLDTKST-DRKQTLLHYISNVVKEKYHQVSLFYNELHYV 888
Query: 867 PEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITVSSFSFSEL 926
+AA V+L + +V L+RG+ + EY ++ +FI + +L
Sbjct: 889 EKAAAVSLENVLLDVKELQRGMDLTK-REYTMHDHN-------TLLKEFILNNEGKLKKL 940
Query: 927 EDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEE-- 984
+D A+D F + +FGE+ P FF +F F++A+ +A ++ E R+K+E+
Sbjct: 941 QDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENEL--RKKQEQAL 998
Query: 985 -ERRARMEAMLKEQRER---ERWQRQRKVLAA---------GSSLEEG--GEFDDLVSAL 1029
E+ EA++++Q + + +RQ++ L A + EG G +D+++ L
Sbjct: 999 MEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITDL 1058
Query: 1030 RS 1031
R+
Sbjct: 1059 RN 1060
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 328 bits (840), Expect = 2e-89
Identities = 247/862 (28%), Positives = 417/862 (48%), Gaps = 139/862 (16%)
Query: 173 IHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGG 232
+H ++ C++A+MN G V++ P A++ IA SL +N +TK VLE+L AVCLV GG
Sbjct: 224 VHVCIL-CLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGG 282
Query: 233 HKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDE---VNLKTAIMSFINAVLNAGA 289
H+ +L A +++ E RF+ L+ +R+E ++ A M FIN V+++
Sbjct: 283 HEIILAAFDNFKEVCKELHRFEKLME-------YFRNEDSNIDFMVACMQFINIVVHS-- 333
Query: 290 GEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMV 349
+++ FR+HL+YEF LG++ + K R E+ L + + L FD+
Sbjct: 334 -VEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAY----------LDNVFDV- 381
Query: 350 HIDTKSASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIV 409
GG + + + L+++
Sbjct: 382 ------------------------------------------GGLLEDAETKNVALEKVE 399
Query: 410 LQDER--GVDPDLAPLENFNVKNIV----NMLINENEVKQWRDQAEKFRKEHMELVSRLE 463
+E + L LEN N+ + +L E E++ ++ E + + RL
Sbjct: 400 ELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYEN-TSHQVHTLRRLI 458
Query: 464 RKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPP 523
+++ E + E +R L + +S+ L AR AEL + ++ P
Sbjct: 459 KEKEEAFQRRCHLEPNVRGLESV------DSEAL--ARVGPAELSEGMPPSDLDLLAPAP 510
Query: 524 PPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTP--PGAPPCLGMGLPL 581
PP L L PPP PPL PPPPPPLP PP P PGA P + + + L
Sbjct: 511 PPEEVLPLP--------PPPAPPL------PPPPPPLPDKCPPAPPLPGAAPSVVLTVGL 556
Query: 582 PQDPYPSSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFE 641
+R K+ + L FNW L ++ GTV++E+DD ++ LDL+ FE
Sbjct: 557 S---------AIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFE 607
Query: 642 KMFSAYQRHQKELGSTEDIYLASRK-----VKELSVIDGRRAQNCIILLSKLKLSNEEIR 696
++F K G D+ + K ++++++ RA+N I L K S EEI
Sbjct: 608 ELFKT-----KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEIC 662
Query: 697 QAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHE---IERMARADRFLYEMSRID 753
+AI D Q L D +E L++F+P ++++ LL +++ E +E +A DRF+ S+++
Sbjct: 663 RAIHTFDLQ-TLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVE 721
Query: 754 HYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQ 813
QR+ + F FQ+ L P++ AI+ AS + S++L+QMLE+ILA+GN+MN +
Sbjct: 722 RLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK 781
Query: 814 RGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVN 873
RG YGF++ SL+ + DTKS+ DR ++LLH++ + +++ +PD+ N EL + +AA V+
Sbjct: 782 RGAVYGFKLQSLDLLLDTKST-DRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 840
Query: 874 LAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEA 933
L + +V L RG+ + RE S V+ +F++ + +L+ A
Sbjct: 841 LENVLLDVKELGRGMELIR---------RECSIHDNSVLRNFLSTNEGKLDKLQRDAKTA 891
Query: 934 RDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAM 993
+ + + +FGE P FF +F F++++ EA Q+ EA R+K+EE R + A
Sbjct: 892 EEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEA--RKKQEEVMREKQLAQ 949
Query: 994 ------LKEQRERERWQRQRKV 1009
K +R +WQ+Q +
Sbjct: 950 EAKKLDAKTPSQRNKWQQQELI 971
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 317 bits (813), Expect = 3e-86
Identities = 288/1076 (26%), Positives = 467/1076 (43%), Gaps = 213/1076 (19%)
Query: 41 PIPNAEELNIRFAELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPD 100
P+P A EL RF ++ ++L + + EKKW++ C +++ Q + P
Sbjct: 28 PMPAAGELEERFNRALNCMNLPPDKVQLLSQYDNEKKWELICDQERFQ------VKNPPA 81
Query: 101 YYIDRINS-----------MAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFI 149
YI ++ S A S F + + QV+ +L+T+LRT + +V F+
Sbjct: 82 AYIQKLKSYVDTGGVSRKVAADWMSNLGF-KRRVQESTQVLRELETSLRTNHIGWVQEFL 140
Query: 150 --ELEGLTCLLNFL-----------RSMDHATCESRIHTSLIGCI--------------- 181
E GL LL +L S D+ S + L +
Sbjct: 141 NEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKPLEQSVEDLSKGPPSSVPKSR 200
Query: 182 ------------KALMNN----------------------SQGRAHVLAQPEAISTIAQS 207
KAL N+ G + V+ P ++ IA S
Sbjct: 201 HLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALS 260
Query: 208 LRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRY 267
L +N +TK VLE+L AVCLV GGH +L A +++ E+ RF+ L+ +
Sbjct: 261 LNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLME-------YF 313
Query: 268 RDE---VNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAIL 324
R+E ++ A M FIN V+++ +N+ FR+ L+YEF LG+ +++LR E+ L
Sbjct: 314 RNEDSNIDFMVACMQFINIVVHS---VENMNFRVFLQYEFTHLGLDLYLERLRLTESDKL 370
Query: 325 DKHLDFFEMVRNEDDLELARRFDMVHI--DTKSASQMFELIHKKLKYTEAYPCLLSVLHH 382
+ + L FD+ + DT++ + +VL H
Sbjct: 371 QVQIQAY----------LDNIFDVGALLEDTETKN--------------------AVLEH 400
Query: 383 CLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVK 442
++ + +Q+ L ER L EN ++ I + E ++
Sbjct: 401 ------------------MEELQEQVALLTER-----LRDAENESMAKIAEL---EKQLS 434
Query: 443 QWRDQAEKFRKEHMELVS-----RLERKER------------ECETKTLEKEEMMRTLNK 485
Q R + E R+ E + R E+ E + + LE++ ++R L
Sbjct: 435 QARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRG 494
Query: 486 MKDKLARESQELRQA-------------RGQVAELVAQLSELSTGPVSSPPPPGGPLTLS 532
D ++ E + A G + +A +E + G + PPPP P S
Sbjct: 495 PGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPG-AAPPPPPPLPGLPS 553
Query: 533 SSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVP 592
PP PPLP PPP PPLP PP PP PP G P+P P P P
Sbjct: 554 PQEAPPSAPPQAPPLP-GSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPP 612
Query: 593 -----------------LRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRIL 635
++ K+ Q + NWV L ++ GTV+ E++D +V + L
Sbjct: 613 GGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQEL 672
Query: 636 DLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEI 695
D+ DFE+ F + S A + + ++I+ RA+N I L K L E I
Sbjct: 673 DMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERI 732
Query: 696 RQAILKMDEQEDLAKDMLEQLLKFIP---EKSDIDLLEEHKHEIERMARADRFLYEMSRI 752
QAI D Q L D LE L++F+P E+S I E + +E ++ DRF+ SRI
Sbjct: 733 CQAIEAYDLQA-LGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRI 791
Query: 753 DHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKG 812
+R+ L F F + P++ AI+ AS + S +LRQ+LE++LA GN+MN
Sbjct: 792 PRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSS 851
Query: 813 QRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKV 872
+RG AYGFR+ SL+ + + KS+ DR +LLHYL+ ++ + +P + S+L L +A V
Sbjct: 852 KRGAAYGFRLQSLDALLEMKST-DRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSV 910
Query: 873 NLAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNE 932
+L + +V +L+RGL QR VR+ V+ +F+ +S + +L
Sbjct: 911 SLDSVLADVRSLQRGLELT-----QREFVRQDD---CMVLKEFLRANSPTMDKLLADSKT 962
Query: 933 ARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRA 988
A++ F + +FGE+ P FF +F F++A+ +A Q++E ++ +E A
Sbjct: 963 AQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGA 1018
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 290 bits (742), Expect = 5e-78
Identities = 261/993 (26%), Positives = 440/993 (44%), Gaps = 121/993 (12%)
Query: 144 FVTRFIELEGLTCLLNFLRSMDHA----TCESRIHTSLIGCIKALMNNSQGRAHVLAQPE 199
++ +F+E GL LL L + ++ + + + C++A+MN+ QG ++L+
Sbjct: 64 WMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQG 123
Query: 200 AISTIAQSLRTENSKTKVAVLEILGAVCLV-PGGHKKVLQAMLHYQVYAAERTRFQTLLN 258
+ ++Q+L T N K V E+L A+C+ P GH L A+ HY+ +++ RF ++N
Sbjct: 124 YVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMN 183
Query: 259 ELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQ 318
EL S D V ++S INAV+ G ++L R LR EF+ L + V+ +LR
Sbjct: 184 ELSGS-----DNVPYVVTLLSVINAVI---LGPEDLRARTQLRNEFIGLQLLDVLARLRD 235
Query: 319 HENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLS 378
E+A L L+ FE + ED+ EL R V D S ++F + K+ + LLS
Sbjct: 236 LEDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPVSAQLLS 293
Query: 379 VLHHCLQM-PYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLIN 437
VL L + P R+ W+ L+ ++ + VL + + ++ +V L++
Sbjct: 294 VLQGLLHLEPTLRSSQLL--WEALESLVNRAVLL--------ASDAQECTLEEVVERLLS 343
Query: 438 ENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQEL 497
+ R + K H + + L++ +R + + ++ + A + +
Sbjct: 344 V----KGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKP--SVEGQQPAAAAACEPV 397
Query: 498 RQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLP------FAC 551
A+ + V+Q L S+PPPP P L S PPPPPPLP
Sbjct: 398 DHAQSESILKVSQPRALEQ-QASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPT 456
Query: 552 CPPPPP--------PPLPPGGPPTP-------PGAPPCLGMGLPLPQDPY--------PS 588
PPPPP PP PP PP P P PP G+G P P P P
Sbjct: 457 APPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPP 516
Query: 589 SDVPL-------------------------------RKKRVPQPSHPLKSFNWVKL--NE 615
PL +RV P+ +K NW KL N
Sbjct: 517 PPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNV 576
Query: 616 ERVPGTVWNEIDDMQVFRIL-DLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKELSVID 674
R ++W + + D E++FS KE T A ++ KE++ +D
Sbjct: 577 AREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKE--PTMVAPRARKEPKEITFLD 634
Query: 675 GRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKH 734
+++ N I L + K SNEE+ A+++ + ++L+QLLK +PEK +I+ L
Sbjct: 635 AKKSLNLNIFLKQFKCSNEEVA-AMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTE 693
Query: 735 EIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKR 794
E ++A AD F + I YQ R++ + + L +PK + +L A L+ S++
Sbjct: 694 ERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQ 753
Query: 795 LRQMLEVILAIGNFMNKGQR-GGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHF 853
L ++IL IGNF+N G G A GF++++L K+ +TKS +R ++LLH+++ EK
Sbjct: 754 LPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNR-VTLLHHVLEEAEKSH 812
Query: 854 PDILNMPSELQHLPEAAKVNLAELEKEV-GNLRRGLRAVEVLEYQRRQVREPSDKFVPVM 912
PD+L +P +L+ +AA +NL + E NL++ L + +V+E
Sbjct: 813 PDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQ-------Y 865
Query: 913 SDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQ 972
++ + S +F L++ K + + E ++ ++ F F F
Sbjct: 866 TERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLF----- 920
Query: 973 DLEAMRRRKEEEERRA----RMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSA 1028
L A++ K+ +E+ A R + + +E+ R R + + V EE D L++
Sbjct: 921 -LRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLAD 979
Query: 1029 LRSGEVFDKDLCKLKRSRKRSGSQALEVTRERA 1061
+R G F R GS+A + RA
Sbjct: 980 IRKG--FQLRKTARGRGDTDGGSKAASMDPPRA 1010
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 290 bits (742), Expect = 5e-78
Identities = 261/993 (26%), Positives = 440/993 (44%), Gaps = 121/993 (12%)
Query: 144 FVTRFIELEGLTCLLNFLRSMDHA----TCESRIHTSLIGCIKALMNNSQGRAHVLAQPE 199
++ +F+E GL LL L + ++ + + + C++A+MN+ QG ++L+
Sbjct: 64 WMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQG 123
Query: 200 AISTIAQSLRTENSKTKVAVLEILGAVCLV-PGGHKKVLQAMLHYQVYAAERTRFQTLLN 258
+ ++Q+L T N K V E+L A+C+ P GH L A+ HY+ +++ RF ++N
Sbjct: 124 YVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMN 183
Query: 259 ELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQ 318
EL S D V ++S INAV+ G ++L R LR EF+ L + V+ +LR
Sbjct: 184 ELSGS-----DNVPYVVTLLSVINAVI---LGPEDLRARTQLRNEFIGLQLLDVLARLRD 235
Query: 319 HENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLS 378
E+A L L+ FE + ED+ EL R V D S ++F + K+ + LLS
Sbjct: 236 LEDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPVSAQLLS 293
Query: 379 VLHHCLQM-PYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLIN 437
VL L + P R+ W+ L+ ++ + VL + + ++ +V L++
Sbjct: 294 VLQGLLHLEPTLRSSQLL--WEALESLVNRAVLL--------ASDAQECTLEEVVERLLS 343
Query: 438 ENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQEL 497
+ R + K H + + L++ +R + + ++ + A + +
Sbjct: 344 V----KGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKP--SVEGQQPAAAAACEPV 397
Query: 498 RQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLP------FAC 551
A+ + V+Q L S+PPPP P L S PPPPPPLP
Sbjct: 398 DHAQSESILKVSQPRALEQ-QASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPT 456
Query: 552 CPPPPP--------PPLPPGGPPTP-------PGAPPCLGMGLPLPQDPY--------PS 588
PPPPP PP PP PP P P PP G+G P P P P
Sbjct: 457 APPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPP 516
Query: 589 SDVPL-------------------------------RKKRVPQPSHPLKSFNWVKL--NE 615
PL +RV P+ +K NW KL N
Sbjct: 517 PPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNV 576
Query: 616 ERVPGTVWNEIDDMQVFRIL-DLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKELSVID 674
R ++W + + D E++FS KE T A ++ KE++ +D
Sbjct: 577 AREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKE--PTMVAPRARKEPKEITFLD 634
Query: 675 GRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKH 734
+++ N I L + K SNEE+ A+++ + ++L+QLLK +PEK +I+ L
Sbjct: 635 AKKSLNLNIFLKQFKCSNEEVA-AMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTE 693
Query: 735 EIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKR 794
E ++A AD F + I YQ R++ + + L +PK + +L A L+ S++
Sbjct: 694 ERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQ 753
Query: 795 LRQMLEVILAIGNFMNKGQR-GGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHF 853
L ++IL IGNF+N G G A GF++++L K+ +TKS +R ++LLH+++ EK
Sbjct: 754 LPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNR-VTLLHHVLEEAEKSH 812
Query: 854 PDILNMPSELQHLPEAAKVNLAELEKEV-GNLRRGLRAVEVLEYQRRQVREPSDKFVPVM 912
PD+L +P +L+ +AA +NL + E NL++ L + +V+E
Sbjct: 813 PDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQ-------Y 865
Query: 913 SDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQ 972
++ + S +F L++ K + + E ++ ++ F F F
Sbjct: 866 TERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLF----- 920
Query: 973 DLEAMRRRKEEEERRA----RMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSA 1028
L A++ K+ +E+ A R + + +E+ R R + + V EE D L++
Sbjct: 921 -LRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLAD 979
Query: 1029 LRSGEVFDKDLCKLKRSRKRSGSQALEVTRERA 1061
+R G F R GS+A + RA
Sbjct: 980 IRKG--FQLRKTARGRGDTDGGSKAASMDPPRA 1010
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 263 bits (672), Expect = 7e-70
Identities = 178/568 (31%), Positives = 294/568 (51%), Gaps = 40/568 (7%)
Query: 523 PPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLP--PGGPPTPPGA------PPC 574
PPP PL S+ +PPPPPPLP PPPPPPLP PG PP PP PP
Sbjct: 679 PPPPPPLPGSAG-----IPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP 733
Query: 575 LGMGLPLPQDPY-------PSSDVPLRKKRVPQPSHPLKSFNWVKL-NEERVPGTVWNEI 626
GMG+P P P+ P L K++ +P L+ NW KL E+ W ++
Sbjct: 734 PGMGMP-PPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKV 792
Query: 627 DDMQVFRILDLEDFEKM---FSAYQRHQK----ELGSTEDIYLASRKVKELSVIDGRRAQ 679
+ R + E F K+ FSA + K + G E + +KVKEL V+D + AQ
Sbjct: 793 KED---RFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQ 849
Query: 680 NCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERM 739
N I L ++ +EI+ IL+++E L + M++ L+K +PE + +L E K E + +
Sbjct: 850 NLSIFLGSFRMPYQEIKNVILEVNEAV-LTESMIQNLIKQMPEPEQLKMLSELKDEYDDL 908
Query: 740 ARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQML 799
A +++F M + + RL A+ FK +F E++ KP++ ++ A EL +S+ +L
Sbjct: 909 AESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLL 968
Query: 800 EVILAIGNFMNKGQR-GGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILN 858
E+ L +GN+MN G R GA+GF ++ L K+ DTKS+ D+ ++LLH+L + E +PD+L
Sbjct: 969 EITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKST-DQKMTLLHFLAELCENDYPDVLK 1027
Query: 859 MPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITV 918
P EL H+ +A++V+ L+K + +++ + VE + DKFV M+ F+
Sbjct: 1028 FPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKD 1087
Query: 919 SSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMR 978
+ +++L + + + +F K+ +EFF F F +A ++ R
Sbjct: 1088 AQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKE-NQKR 1146
Query: 979 RRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVFDKD 1038
R EE+ RRA++ E+ E+ Q++ +++ + +E G D L+ AL+SG F +
Sbjct: 1147 RETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRK 1206
Query: 1039 LCKLKRSRKR----SGSQALEVTRERAI 1062
+ +RK + A E+T++ A+
Sbjct: 1207 RGPRQANRKAGCAVTSLLASELTKDDAM 1234
Score = 173 bits (439), Expect = 7e-43
Identities = 139/506 (27%), Positives = 238/506 (47%), Gaps = 61/506 (12%)
Query: 130 VEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDH------ATCESRIHTSLIGCIKA 183
+E L+ +L P+ +V F EGL LL+ L+ + + +SR +I C+KA
Sbjct: 156 LESLRVSLNNNPVSWVQTF-GAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKA 214
Query: 184 LMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGG---HKKVLQAM 240
MNN G +L E I + +++ + ++L A+C++P +++VL+AM
Sbjct: 215 FMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAM 274
Query: 241 LHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHL 300
+ E RFQ LL+ L + LK + INA++ + L+FR+H+
Sbjct: 275 TE-RAEMDEVERFQPLLDGLKSGT-----TIALKVGCLQLINALITPA---EELDFRVHI 325
Query: 301 RYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMF 360
R E + LG+ V+ LR+ EN + L+ F+ ED +L R D + ++ +++F
Sbjct: 326 RSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVF 385
Query: 361 ELIHKKLKYTEAYPCLLSVLHHCL--QMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDP 418
+++ +K ++A P LS+L H L + Y+ Y+ +L++ + QIVL + G DP
Sbjct: 386 QILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYY---KLIEECISQIVLH-KNGADP 441
Query: 419 DLAPLE-NFNVKNIVNMLINENEVKQWRDQAEKFRKE-------HMELVSRLERKERECE 470
D ++ +++ +I++ +V++ +A + K+ EL +++ E + E
Sbjct: 442 DFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFE 501
Query: 471 TKTLEKEEMMRTLNKMKDKLARESQELR----QARGQVAELVAQLSE-------LSTGPV 519
K + + L+ K ++A E Q+L Q G+VA+L +L + LS +
Sbjct: 502 QKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAI 561
Query: 520 SSPP--------PPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPG- 570
+ PP PP PL S PPPP P PPPPPP PP PP P G
Sbjct: 562 TVPPSVPSRAPVPPAPPLPGDSGTII-----PPPPAPGDSTTPPPPPPPPPPPPPLPGGV 616
Query: 571 ---APPCLGMGLPLPQDPYPSSDVPL 593
+PP L G + P S D +
Sbjct: 617 CISSPPSLPGGTAISPPPPLSGDATI 642
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 263 bits (672), Expect = 7e-70
Identities = 178/568 (31%), Positives = 294/568 (51%), Gaps = 40/568 (7%)
Query: 523 PPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLP--PGGPPTPPGA------PPC 574
PPP PL S+ +PPPPPPLP PPPPPPLP PG PP PP PP
Sbjct: 688 PPPPPPLPGSAG-----IPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP 742
Query: 575 LGMGLPLPQDPY-------PSSDVPLRKKRVPQPSHPLKSFNWVKL-NEERVPGTVWNEI 626
GMG+P P P+ P L K++ +P L+ NW KL E+ W ++
Sbjct: 743 PGMGMP-PPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKV 801
Query: 627 DDMQVFRILDLEDFEKM---FSAYQRHQK----ELGSTEDIYLASRKVKELSVIDGRRAQ 679
+ R + E F K+ FSA + K + G E + +KVKEL V+D + AQ
Sbjct: 802 KED---RFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQ 858
Query: 680 NCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERM 739
N I L ++ +EI+ IL+++E L + M++ L+K +PE + +L E K E + +
Sbjct: 859 NLSIFLGSFRMPYQEIKNVILEVNEAV-LTESMIQNLIKQMPEPEQLKMLSELKDEYDDL 917
Query: 740 ARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQML 799
A +++F M + + RL A+ FK +F E++ KP++ ++ A EL +S+ +L
Sbjct: 918 AESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLL 977
Query: 800 EVILAIGNFMNKGQR-GGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILN 858
E+ L +GN+MN G R GA+GF ++ L K+ DTKS+ D+ ++LLH+L + E +PD+L
Sbjct: 978 EITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKST-DQKMTLLHFLAELCENDYPDVLK 1036
Query: 859 MPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITV 918
P EL H+ +A++V+ L+K + +++ + VE + DKFV M+ F+
Sbjct: 1037 FPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKD 1096
Query: 919 SSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMR 978
+ +++L + + + +F K+ +EFF F F +A ++ R
Sbjct: 1097 AQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKE-NQKR 1155
Query: 979 RRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVFDKD 1038
R EE+ RRA++ E+ E+ Q++ +++ + +E G D L+ AL+SG F +
Sbjct: 1156 RETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRK 1215
Query: 1039 LCKLKRSRKR----SGSQALEVTRERAI 1062
+ +RK + A E+T++ A+
Sbjct: 1216 RGPRQANRKAGCAVTSLLASELTKDDAM 1243
Score = 173 bits (439), Expect = 7e-43
Identities = 139/506 (27%), Positives = 238/506 (47%), Gaps = 61/506 (12%)
Query: 130 VEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDH------ATCESRIHTSLIGCIKA 183
+E L+ +L P+ +V F EGL LL+ L+ + + +SR +I C+KA
Sbjct: 165 LESLRVSLNNNPVSWVQTF-GAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKA 223
Query: 184 LMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGG---HKKVLQAM 240
MNN G +L E I + +++ + ++L A+C++P +++VL+AM
Sbjct: 224 FMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAM 283
Query: 241 LHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHL 300
+ E RFQ LL+ L + LK + INA++ + L+FR+H+
Sbjct: 284 TE-RAEMDEVERFQPLLDGLKSGT-----TIALKVGCLQLINALITPA---EELDFRVHI 334
Query: 301 RYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMF 360
R E + LG+ V+ LR+ EN + L+ F+ ED +L R D + ++ +++F
Sbjct: 335 RSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVF 394
Query: 361 ELIHKKLKYTEAYPCLLSVLHHCL--QMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDP 418
+++ +K ++A P LS+L H L + Y+ Y+ +L++ + QIVL + G DP
Sbjct: 395 QILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYY---KLIEECISQIVLH-KNGADP 450
Query: 419 DLAPLE-NFNVKNIVNMLINENEVKQWRDQAEKFRKE-------HMELVSRLERKERECE 470
D ++ +++ +I++ +V++ +A + K+ EL +++ E + E
Sbjct: 451 DFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFE 510
Query: 471 TKTLEKEEMMRTLNKMKDKLARESQELR----QARGQVAELVAQLSE-------LSTGPV 519
K + + L+ K ++A E Q+L Q G+VA+L +L + LS +
Sbjct: 511 QKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAI 570
Query: 520 SSPP--------PPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPG- 570
+ PP PP PL S PPPP P PPPPPP PP PP P G
Sbjct: 571 TVPPSVPSRAPVPPAPPLPGDSGTII-----PPPPAPGDSTTPPPPPPPPPPPPPLPGGV 625
Query: 571 ---APPCLGMGLPLPQDPYPSSDVPL 593
+PP L G + P S D +
Sbjct: 626 CISSPPSLPGGTAISPPPPLSGDATI 651
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 200 bits (509), Expect = 5e-51
Identities = 156/514 (30%), Positives = 239/514 (46%), Gaps = 79/514 (15%)
Query: 501 RGQVAELVAQLSELSTGPVSS-----PPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPP- 554
R ++ ++ E S+ SS PPPP LS PPPPPPLPF P
Sbjct: 724 RSSASDCISSSEEGSSLTYSSISDHIPPPP-----LS--------PPPPPPLPFHDAKPS 770
Query: 555 -----------------------PPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDV 591
P PPP PP PP P APP L GL
Sbjct: 771 SRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLG----------- 819
Query: 592 PLRKKRVPQPSH-PLKSFNWVKLNEERVPGTVWNEI-DDMQVFRILDLE---DFEKMFSA 646
R + SH +K W ++ E GT+W ++ +D ++ D+ D E F
Sbjct: 820 ----HRRSETSHMSVKRLRWEQV--ENSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGT 873
Query: 647 YQRHQKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQE 706
Q+ K + E RK + + ++ ++A N ILL+ LKLS E+RQ ++ M+ +
Sbjct: 874 -QKPAKPVPGPEPF----RKKEVVEILSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRR 928
Query: 707 DLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKK 766
L L QLL F P+ + + + R++ D+F+ +M + Y+ RL++L F+
Sbjct: 929 -LEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQA 987
Query: 767 KFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQ--RGGAYGFRVAS 824
QE+ E + +E + AS EL S++L ++LE +LA+GN++N GQ GF++
Sbjct: 988 TLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINF 1047
Query: 825 LNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNL 884
L ++ TK ++D + LH L L +HFP++L +L +P AAKVN L ++ +L
Sbjct: 1048 LTELNSTK-TVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTSDLADL 1106
Query: 885 RRGLRAVEVLEYQRRQVREPS--DKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALM 942
+ ++ Q PS DKF VMS F+ + + L+ EA ++ KAL
Sbjct: 1107 HGTISEIQ----DACQSISPSSEDKFAMVMSSFLETAQPALRALDGLQREAMEELGKALA 1162
Query: 943 HFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEA 976
FGE + FFGIF F+ F A DL+A
Sbjct: 1163 FFGEDSKATTSEAFFGIFAEFMSKFERALSDLQA 1196
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 187 bits (475), Expect = 5e-47
Identities = 147/523 (28%), Positives = 242/523 (46%), Gaps = 73/523 (13%)
Query: 518 PVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACC---------PPPPPPPLP--PGGPP 566
P +PPPP PPPPPP P C PPPPPPPLP P PP
Sbjct: 30 PPPAPPPP---------------PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPP 74
Query: 567 TPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPG--TVWN 624
PPG PP M + Y +KKR ++SF W + EE+V G +W
Sbjct: 75 PPPGLPPTTHM------NGYSHLG---KKKR-------MRSFFWKTIPEEQVRGKTNIWT 118
Query: 625 EIDDMQVFRILDLEDFEKMF--------SAYQRHQKELGSTEDIYLASRKVKELSVIDGR 676
+ +D + E++F S+ R + L S+ + +R+ E++++D +
Sbjct: 119 LAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSS---FREARE--EITILDAK 173
Query: 677 RAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEI 736
R+ N I L + K S I + I + E + L + LKF+PE ++ L+ ++
Sbjct: 174 RSMNIGIFLKQFKKSPRSIVEDI-HQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDV 232
Query: 737 ERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLR 796
+++ AD FLY + ++ +Y R++A+ KK+F + + + A +EL+ + L
Sbjct: 233 SKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELH 292
Query: 797 QMLEVILAIGNFMNK-GQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPD 855
+L ++L GN MN G G A GF+++SL K+ADTK++ ++LLH++ +K
Sbjct: 293 SILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKAN-KPGMNLLHFVAQEAQKKDTI 351
Query: 856 ILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDF 915
+LN +L H+ + A+++L E E L + V ++ + + M DF
Sbjct: 352 LLNFSEKLHHVQKTARLSLENTEAE-------LHLLFVRTKSLKENIQRDGELCQQMEDF 404
Query: 916 ITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLE 975
+ + ELE E +D+ + F E M+ DE F IF F F++A +D
Sbjct: 405 LQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKD-- 462
Query: 976 AMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEE 1018
+ E + R LKEQ +++R ++ A G S E
Sbjct: 463 ----NHDREAQELRQLQRLKEQEQKQRSWATGELGAFGRSSSE 501
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 184 bits (466), Expect = 5e-46
Identities = 148/555 (26%), Positives = 256/555 (46%), Gaps = 68/555 (12%)
Query: 510 QLSELSTGPVSSPPPPGGPLTLSSSMTTNDLPP------------PPPPLPFACC----P 553
Q L P S PPPP P L S +PP PPPPLP P
Sbjct: 641 QQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPP 700
Query: 554 PPPPPPLP----PGGPPTPPGAPPCLGMGLPLPQDPY---PSSDVPLRKKRVPQPSHPLK 606
PPPPPPLP P P PP APP G+ P P + SS +K +PS P+K
Sbjct: 701 PPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSSSQCPRKPAIEPSCPMK 760
Query: 607 SFNWVKLN----EERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYL 662
W ++ + T+W+ +++ I D +FE +FS QK+ +E
Sbjct: 761 PLYWTRIQISDRSQNATPTLWDSLEEPD---IRDPSEFEYLFSKDTTQQKKKPLSETYEK 817
Query: 663 ASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPE 722
++ K + ++DG+R+Q IL+S L L ++I+QAI +D+ + + L L + +
Sbjct: 818 KNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDDSV-VDLETLAALYENRAQ 876
Query: 723 KSDIDLLEEH-----KHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKP 777
+ ++ + ++ + E++ + + ++FL+E+++I ++ +R Q + F+ F E +
Sbjct: 877 EDELVKIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSEGITSLHR 936
Query: 778 KVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQ--RGGAYGFRVASLNKIADTKSSI 835
KVE I AS++L+ K ++ +L +ILA GN+MN G RG A G+ + L K+ D KS
Sbjct: 937 KVEIITRASKDLLHVKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSR- 995
Query: 836 DRNISLLHYLIMILEKHFPDILNMPSELQHLPE------AAKVNLAELEKEVGNLRRGLR 889
D I+L+ Y++ +++ + LPE A++V +L K++ L+R L
Sbjct: 996 DNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQVKFEDLIKDLRKLKRQLE 1055
Query: 890 AVE--VLEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFG-- 945
A E ++ + +E F + +F + E L A+ F + +FG
Sbjct: 1056 ASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKKEHKMEESHLENAQKSFETTVRYFGMK 1115
Query: 946 --EHDSKMQPDEFFGIFDTFLQAFSE----------------ARQDLEAMRRRKEEEERR 987
+ ++ P F ++ F F A++ + + K+ E ++
Sbjct: 1116 PKSGEKEITPSYVFMVWYEFCSDFKTIWKRESKNISKERLKMAQESVSKLTSEKKVETKK 1175
Query: 988 ARMEAMLKEQ-RERE 1001
A LKE+ R++E
Sbjct: 1176 INPTASLKERLRQKE 1190
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 168 bits (426), Expect = 2e-41
Identities = 150/523 (28%), Positives = 240/523 (45%), Gaps = 67/523 (12%)
Query: 519 VSSPPPPGGPLTLSSSMTTNDLP----PPPPPLPFACCPPPPPPPLPPGGPPTPP----- 569
V PPPP PL LP PPPPPLP PP P PPLPP G PP
Sbjct: 1182 VGIPPPP--PLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLP 1239
Query: 570 -GAPPCL----GMGLPLPQ------DPYPSSDVPL-------RKKRVPQPSHPLKSFNW- 610
PP L LP PQ P PS L +K+ +P P+K W
Sbjct: 1240 VSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWT 1299
Query: 611 -VKLNEERVPGT--VWNEIDDMQVFRILDLEDFEKMFS--AYQRHQKELGSTEDIYLASR 665
++L+ +R T +W +I++ + D +FE++FS A + +K + T A +
Sbjct: 1300 RIQLHSKRDSSTSLIWEKIEEPSI----DCHEFEELFSKTAVKERKKPISDTISKTKAKQ 1355
Query: 666 KVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSD 725
VK LS +R+Q IL+S L L ++I+ A++ +D + + L+ L + + +
Sbjct: 1356 VVKLLS---NKRSQAVGILMSSLHLDMKDIQHAVVNLDNSV-VDLETLQALYENRAQSDE 1411
Query: 726 IDLLEEH------KHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKV 779
++ +E+H K + + + ++FLYE+S I ++ +R+ + F+ F E + + K+
Sbjct: 1412 LEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKL 1471
Query: 780 EAILLASRELVRSKRLRQMLEVILAIGNFMNKGQ--RGGAYGFRVASLNKIADTKSSIDR 837
E + L + Q+L ++LA GN+MN G RG A GF + L K+ D KSS D
Sbjct: 1472 ELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSS-DN 1530
Query: 838 NISLLHYLIMILEKHFPDILNMPSELQHLPE------AAKVNLAELEKEVGNLRRGLRAV 891
+ SLL Y++ ++F + L LPE A+++ + +K++ L++ L+A
Sbjct: 1531 SRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKAC 1590
Query: 892 EVLEYQRRQV--REPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEH-- 947
EV + QV +E F M FI + E+ L E F + +F
Sbjct: 1591 EVEAGKVYQVSSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPK 1650
Query: 948 --DSKMQPDEFFGIFDTFLQAFSE---ARQDLEAMRRRKEEEE 985
+ ++ P+ FF I+ F F + L R KE EE
Sbjct: 1651 LGEKEVSPNAFFSIWHEFSSDFKDFWKKENKLLLQERVKEAEE 1693
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/94 (40%), Positives = 43/94 (45%), Gaps = 23/94 (24%)
Query: 518 PVSSPP------PPGGPLTLSSSMTTNDLP----PPPPPLPFACCPPPP---------PP 558
P PP PP PL + + LP PPPPPLP A PPPP PP
Sbjct: 909 PPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPP 968
Query: 559 PLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVP 592
PLP G P PP P G G+P P P P + +P
Sbjct: 969 PLPGAGIPPPPPLP---GAGIP-PPPPLPGAGIP 998
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/80 (42%), Positives = 40/80 (50%), Gaps = 14/80 (17%)
Query: 522 PPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPP---------PPPPPLPPGGPPTPPGAP 572
PP PG + L + + PPPPPLP A PP PPPPPLP G P PP P
Sbjct: 957 PPLPGAGIPLPPPLPGAGI-PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1015
Query: 573 PCLGMGLPLPQDPYPSSDVP 592
G G+P P P P + +P
Sbjct: 1016 ---GAGIP-PPPPLPGAGIP 1031
Score = 58.5 bits (140), Expect = 3e-08
Identities = 41/95 (43%), Positives = 45/95 (47%), Gaps = 24/95 (25%)
Query: 519 VSSPPPPGGPLTLSSSMTTNDLP----PPPPPLPFACCPP---------PPPPPLPPGG- 564
V PPPP PL + LP PPPPPLP A PP PPPPPLP G
Sbjct: 1105 VGIPPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGI 1162
Query: 565 --PPTPPGA-----PPCLGMGLPLPQDPYPSSDVP 592
PP PGA PP G+G+P P P P +P
Sbjct: 1163 PPPPPLPGAGIPPPPPLPGVGIP-PPPPLPGVGIP 1196
Score = 58.2 bits (139), Expect = 4e-08
Identities = 40/100 (40%), Positives = 44/100 (44%), Gaps = 30/100 (30%)
Query: 522 PPPPGGPLTLSSSMTTN--DLPPPPPPLPFACCP-------------------PPPPPPL 560
P PP P T SSS +PPPPPPLP P PPPPPPL
Sbjct: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPL 915
Query: 561 PPGG---PPTPPGA-----PPCLGMGLPLPQDPYPSSDVP 592
P G PP PGA PP G G+P P P P + +P
Sbjct: 916 PGAGIPPPPPLPGAGILPLPPLPGAGIP-PPPPLPGAAIP 954
Score = 58.2 bits (139), Expect = 4e-08
Identities = 37/84 (44%), Positives = 41/84 (48%), Gaps = 19/84 (22%)
Query: 522 PPPPGGPLTLSSSMTTNDLP----PPPPPLPFACCPP---------PPPPPLPPGGPPTP 568
PPPP PL + LP PPPPPLP A PP PPPPPLP G P P
Sbjct: 987 PPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1044
Query: 569 PGAPPCLGMGLPLPQDPYPSSDVP 592
P P G G+P P P P + +P
Sbjct: 1045 PPLP---GAGIP-PPPPLPGAGIP 1064
Score = 58.2 bits (139), Expect = 4e-08
Identities = 37/84 (44%), Positives = 41/84 (48%), Gaps = 19/84 (22%)
Query: 522 PPPPGGPLTLSSSMTTNDLP----PPPPPLPFACCPP---------PPPPPLPPGGPPTP 568
PPPP PL + LP PPPPPLP A PP PPPPPLP G P P
Sbjct: 1020 PPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1077
Query: 569 PGAPPCLGMGLPLPQDPYPSSDVP 592
P P G G+P P P P + +P
Sbjct: 1078 PPLP---GAGIP-PPPPLPGAGIP 1097
Score = 57.4 bits (137), Expect = 7e-08
Identities = 43/105 (40%), Positives = 49/105 (46%), Gaps = 28/105 (26%)
Query: 522 PPPPGGPLTLSSSMTTNDLP----PPPPPLPFACCPP---------PPPPPLPPGG---P 565
PPPP PL + LP PPPPPLP A PP PPPPPLP G P
Sbjct: 1053 PPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPP 1110
Query: 566 PTPPGA-----PPCLGMGLPLPQDPYPSSDV----PLRKKRVPQP 601
P PGA PP G G+P P P P + + PL + +P P
Sbjct: 1111 PPLPGAGIPPPPPLPGAGIP-PPPPLPGAGIPPPPPLPRVGIPPP 1154
Score = 50.8 bits (120), Expect = 7e-06
Identities = 35/95 (36%), Positives = 42/95 (44%), Gaps = 23/95 (24%)
Query: 517 GPVSSPPPPGGPLTLSSSMTTNDLPPPPP----------PLPFACCPPP---------PP 557
G + PP PG + + +PPPPP PLP A PPP PP
Sbjct: 930 GILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPP 989
Query: 558 PPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVP 592
PPLP G P PP P G G+P P P P + +P
Sbjct: 990 PPLPGAGIPPPPPLP---GAGIP-PPPPLPGAGIP 1020
Score = 39.7 bits (91), Expect = 0.015
Identities = 34/116 (29%), Positives = 39/116 (33%), Gaps = 22/116 (18%)
Query: 512 SELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFAC-------------CPPPPPP 558
S T +S PPPP L + PP F C P PP
Sbjct: 800 SHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPP 859
Query: 559 PLP--------PGGPPTPPGAPPCLGMGLP-LPQDPYPSSDVPLRKKRVPQPSHPL 605
PLP PG PP PP GM +P LP P + +P P PL
Sbjct: 860 PLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPL 915
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 129 bits (323), Expect = 2e-29
Identities = 110/375 (29%), Positives = 179/375 (47%), Gaps = 33/375 (8%)
Query: 529 LTLSSSMTTNDLPPPPPPLPF--ACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPY 586
L + S D+P P PPLP PPPP PP PP P PP PP L + PLP
Sbjct: 558 LNVESVEAGKDIPAPSPPLPLLSGVPPPPPLPPPPPIKGPFPP--PPPLPLAAPLPHSVP 615
Query: 587 PSSDVPLRKKRVPQPSHPLKSFNWVKLNEERVP--GTVWNEIDDMQVFRILDLEDFEKMF 644
SS +P ++K V LK ++ R T+W +D + V D ++
Sbjct: 616 DSSALPTKRKTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSV-------DTARLE 668
Query: 645 SAYQRHQKELGSTEDIYLASRKVKE-----LSVIDGRRAQNCIILLSKLKLSNEEIRQAI 699
++ KE+ L S+K E +V+D +R+ I L+ L I+ A+
Sbjct: 669 HLFESRAKEV-------LPSKKAGEGRRTMTTVLDPKRSNAINIGLTTLP-PVHVIKAAL 720
Query: 700 LKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHK--HEIERMARADRFLYEMSRIDHYQQ 757
L DE ++KD +E+LL +P + + +EE + + + A+ FL ++ I
Sbjct: 721 LNFDEFA-VSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAA 779
Query: 758 RLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGA 817
RLQ FK + E + + + +LV++ R +L +LA+GNF+N Q +
Sbjct: 780 RLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQ---S 836
Query: 818 YGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAEL 877
GF ++ L K+++ K ++ R SLLH+L ++ + P+ ++ SE+ L AKV+ +L
Sbjct: 837 SGFELSYLEKVSEVKDTVRRQ-SLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQL 895
Query: 878 EKEVGNLRRGLRAVE 892
+ +G L R RA E
Sbjct: 896 TENLGQLERRSRAAE 910
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 127 bits (318), Expect = 7e-29
Identities = 106/361 (29%), Positives = 172/361 (47%), Gaps = 26/361 (7%)
Query: 541 PPPPPPLPFACCPPPPPPPLPPGGPPTP-PG-----APPCLG--MGLPLPQDPYPSSDVP 592
PPPPPP F PPPPPPPL PP P PG PP GL Q P
Sbjct: 846 PPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRGQPTFT 905
Query: 593 LRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQK 652
+KK + + ++ F+W N R +W++++ ++V D ++ ++ K
Sbjct: 906 KKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKV-------DTSRLEHLFESKSK 958
Query: 653 ELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDM 712
EL S A K +E+ V+D +R+ I L+ L I+ AIL DE L K+
Sbjct: 959 EL-SVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLP-PPRTIKIAILNFDEYA-LNKEG 1015
Query: 713 LEQLLKFIP---EKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQ 769
+E++L IP EK I + EI + A++FL +S I RL FK ++
Sbjct: 1016 IEKILTMIPTDEEKQKIQEAQLANPEIP-LGSAEQFLLTLSSISELSARLHLWAFKMDYE 1074
Query: 770 ERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIA 829
E + + +L +K L +L +LAIGNF+N A F ++ L K+
Sbjct: 1075 TTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLN---GTNAKAFELSYLEKVP 1131
Query: 830 DTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLR 889
+ K ++ + SLLH++ ++ ++FPD ++ SE+ + +AKV+ +L+ + + R +
Sbjct: 1132 EVKDTVHKQ-SLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCK 1190
Query: 890 A 890
A
Sbjct: 1191 A 1191
Score = 32.0 bits (71), Expect = 3.2
Identities = 40/152 (26%), Positives = 63/152 (41%), Gaps = 15/152 (9%)
Query: 418 PDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKT-LEK 476
P A LE + ++ +++ + + E+ R+E E + R+ER+ER ++ L+K
Sbjct: 430 PQEARLERSSPSGLLTSSFRQHQ-ESLAAERERRRQEREERLQRIEREERNKFSRDYLDK 488
Query: 477 EEMMRTLN----KMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLS 532
E R K ++LA E E V+ A LS T P + P PL+ S
Sbjct: 489 REEQRQAREERYKYLEQLAAEEHEKELRSRSVSRGRADLSLDLTSPAA--PACLAPLSHS 546
Query: 533 SS-------MTTNDLPPPPPPLPFACCPPPPP 557
S +T + P P P A P P
Sbjct: 547 PSSSDSQEALTVSASSPGTPHHPQASAGDPEP 578
>gi|14249316 hypothetical protein LOC84800 [Homo sapiens]
Length = 234
Score = 87.4 bits (215), Expect = 6e-17
Identities = 55/179 (30%), Positives = 95/179 (53%), Gaps = 13/179 (7%)
Query: 144 FVTRFIELEGLTCLLNFLRSMDHA----TCESRIHTSLIGCIKALMNNSQGRAHVLAQPE 199
++ +F+E GL LL L + ++ + + + C++A+MN+ QG ++L+
Sbjct: 64 WMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQG 123
Query: 200 AISTIAQSLRTENSKTKVAVLEILGAVCLV-PGGHKKVLQAMLHYQVYAAERTRFQTLLN 258
+ ++Q+L T N K V E+L A+C+ P GH L A+ HY+ +++ RF ++N
Sbjct: 124 YVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMN 183
Query: 259 ELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLR 317
EL S D V ++S INAV+ G ++L R LR EF+ L + V+ +LR
Sbjct: 184 ELSGS-----DNVPYVVTLLSVINAVI---LGPEDLRARTQLRNEFIGLQLLDVLARLR 234
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 77.4 bits (189), Expect = 7e-14
Identities = 59/187 (31%), Positives = 78/187 (41%), Gaps = 56/187 (29%)
Query: 445 RDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELR------ 498
R++ E+ R+E +E RLER+ER + L++E R + ++L RE QE
Sbjct: 193 RERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLE 252
Query: 499 ---------------------------------------QARGQVAELVAQLSELSTGPV 519
QA Q AE +Q + GP+
Sbjct: 253 REQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQ-QGIVLGPL 311
Query: 520 SSPPP---PGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPP-----LPPGGPPTPPGA 571
+ PPP P GP S ++ PPPPPPLP PPPPPPP +PP PP PP A
Sbjct: 312 APPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPP--PPPPPPA 369
Query: 572 PPCLGMG 578
PP G
Sbjct: 370 PPLPASG 376
Score = 34.3 bits (77), Expect = 0.64
Identities = 16/37 (43%), Positives = 24/37 (64%)
Query: 971 RQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQR 1007
R+ L+ +R+KE E R E M +E+ ERER +R+R
Sbjct: 144 RRQLQEQQRQKELERERLERERMERERLERERLERER 180
Score = 33.9 bits (76), Expect = 0.84
Identities = 15/50 (30%), Positives = 30/50 (60%), Gaps = 10/50 (20%)
Query: 975 EAMRRRKEEEERRARMEAMLKEQRERER----------WQRQRKVLAAGS 1014
E + R ++E + R R+E + +E++ERER W+R+R++ +A +
Sbjct: 220 ERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAA 269
Score = 32.3 bits (72), Expect = 2.4
Identities = 23/79 (29%), Positives = 44/79 (55%), Gaps = 6/79 (7%)
Query: 932 EARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSE---ARQDLEAMRRRKEEEERRA 988
E + FA A+MH E + + ++ L A + ++++LE RR+ +E++R+
Sbjct: 95 EDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQK 154
Query: 989 RMEAMLKEQRERERWQRQR 1007
+E +E+ ERER +R+R
Sbjct: 155 ELE---RERLERERMERER 170
Score = 31.2 bits (69), Expect = 5.5
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 969 EARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLE 1017
+ RQ+ E + R + E + R R E + +EQ E ER +R+ AA +S+E
Sbjct: 227 QERQERERLERLERERQERERQEQLEREQLEWER-ERRISSAAAPASVE 274
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 77.4 bits (189), Expect = 7e-14
Identities = 59/187 (31%), Positives = 78/187 (41%), Gaps = 56/187 (29%)
Query: 445 RDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELR------ 498
R++ E+ R+E +E RLER+ER + L++E R + ++L RE QE
Sbjct: 193 RERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLE 252
Query: 499 ---------------------------------------QARGQVAELVAQLSELSTGPV 519
QA Q AE +Q + GP+
Sbjct: 253 REQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQ-QGIVLGPL 311
Query: 520 SSPPP---PGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPP-----LPPGGPPTPPGA 571
+ PPP P GP S ++ PPPPPPLP PPPPPPP +PP PP PP A
Sbjct: 312 APPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPP--PPPPPPA 369
Query: 572 PPCLGMG 578
PP G
Sbjct: 370 PPLPASG 376
Score = 34.3 bits (77), Expect = 0.64
Identities = 16/37 (43%), Positives = 24/37 (64%)
Query: 971 RQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQR 1007
R+ L+ +R+KE E R E M +E+ ERER +R+R
Sbjct: 144 RRQLQEQQRQKELERERLERERMERERLERERLERER 180
Score = 33.9 bits (76), Expect = 0.84
Identities = 15/50 (30%), Positives = 30/50 (60%), Gaps = 10/50 (20%)
Query: 975 EAMRRRKEEEERRARMEAMLKEQRERER----------WQRQRKVLAAGS 1014
E + R ++E + R R+E + +E++ERER W+R+R++ +A +
Sbjct: 220 ERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAA 269
Score = 32.3 bits (72), Expect = 2.4
Identities = 23/79 (29%), Positives = 44/79 (55%), Gaps = 6/79 (7%)
Query: 932 EARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSE---ARQDLEAMRRRKEEEERRA 988
E + FA A+MH E + + ++ L A + ++++LE RR+ +E++R+
Sbjct: 95 EDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQK 154
Query: 989 RMEAMLKEQRERERWQRQR 1007
+E +E+ ERER +R+R
Sbjct: 155 ELE---RERLERERMERER 170
Score = 31.2 bits (69), Expect = 5.5
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 969 EARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLE 1017
+ RQ+ E + R + E + R R E + +EQ E ER +R+ AA +S+E
Sbjct: 227 QERQERERLERLERERQERERQEQLEREQLEWER-ERRISSAAAPASVE 274
>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
Length = 3571
Score = 62.0 bits (149), Expect = 3e-09
Identities = 34/87 (39%), Positives = 44/87 (50%), Gaps = 14/87 (16%)
Query: 512 SELSTGPVSSPPPP----------GGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLP 561
S T P PPPP GP+ + ++++T PPP P P PPPPPPP P
Sbjct: 1953 SSPETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPP----PPPPPPPPP 2008
Query: 562 PGGPPTPPGAPPCLGMGLPLPQDPYPS 588
P PP PP APP + + + L +PS
Sbjct: 2009 PPPPPPPPSAPPQVQLPVSLDLPLFPS 2035
Score = 35.4 bits (80), Expect = 0.29
Identities = 22/50 (44%), Positives = 25/50 (50%), Gaps = 6/50 (12%)
Query: 518 PVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPT 567
P S+ P L+LSS+ T L PPPP P PPPPPP G T
Sbjct: 3094 PTSATSSPA--LSLSSAPTKPLLQTPPPPPP----PPPPPPSSSLSGQQT 3137
Score = 33.5 bits (75), Expect = 1.1
Identities = 31/130 (23%), Positives = 45/130 (34%), Gaps = 11/130 (8%)
Query: 475 EKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPP------PGGP 528
+ E+ M +++ K S + A+ A + S ST + SP P P
Sbjct: 2303 QTEDSMDATDQVVYKHCTVSGQTDAAKNAAAPAASSGSGTSTPLIPSPKPEPEKTSPKPE 2362
Query: 529 LTLSSSMTTNDLPP-----PPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQ 583
++ PP P PL PP P P PP P +G Q
Sbjct: 2363 YPAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQPQPQPQPPKQPQLIGRPPSASQ 2422
Query: 584 DPYPSSDVPL 593
P PSS + +
Sbjct: 2423 TPVPSSPLQI 2432
Score = 30.4 bits (67), Expect = 9.3
Identities = 18/47 (38%), Positives = 22/47 (46%), Gaps = 4/47 (8%)
Query: 523 PPPGGPLTLSSSMTTNDLPP--PPPPLPFACCPPPPPPPLPPGGPPT 567
PP G L +S T++ P P PPPPPP PP PP+
Sbjct: 3085 PPGAGMLGFPTSATSSPALSLSSAPTKPLLQTPPPPPP--PPPPPPS 3129
>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
Length = 502
Score = 58.9 bits (141), Expect = 2e-08
Identities = 39/103 (37%), Positives = 43/103 (41%), Gaps = 26/103 (25%)
Query: 518 PVSSPPPPGGPLTLSSSMTTNDLPPPP------------PPLPFACCPPPPPP--PLPP- 562
P+ PPPP S N LP PP PP+P PPPP P P PP
Sbjct: 312 PLPPPPPP--------SRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPG 363
Query: 563 -GGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQPSHP 604
GGPP PP PP G PLP P + P+ P P P
Sbjct: 364 RGGPPPPP--PPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPP 404
Score = 52.4 bits (124), Expect = 2e-06
Identities = 28/57 (49%), Positives = 28/57 (49%), Gaps = 7/57 (12%)
Query: 522 PPPPGGPLTLSSSMTTNDLPPPPPPL---PFACCPPPPPPPLPPGGPPTPPGAPPCL 575
PPPP P T S LPPPPP P PPPPPPP G P PP PP L
Sbjct: 367 PPPPPPPATGRSG----PLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPAL 419
Score = 43.1 bits (100), Expect = 0.001
Identities = 27/68 (39%), Positives = 31/68 (45%), Gaps = 8/68 (11%)
Query: 516 TGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCL 575
+GP+ PPP G + PPPPPP P + P PPPLPP P G P
Sbjct: 378 SGPLPPPPPGAGGPPMPP-------PPPPPPPPPSSGNGPAPPPLPPALVPA-GGLAPGG 429
Query: 576 GMGLPLPQ 583
G G L Q
Sbjct: 430 GRGALLDQ 437
Score = 32.3 bits (72), Expect = 2.4
Identities = 24/63 (38%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query: 540 LPPPPPPLPFACCPPPPPPPLPPGGPPT-PPGAPPCLGMGLPLPQDPYPSSDVPLRKKRV 598
LPPPP P PP PL PGG PP P LG+ Q+P +S R + +
Sbjct: 159 LPPPPTPANEERRGGLPPLPLHPGGDQGGPPVGPLSLGLATVDIQNPDITSS---RYRGL 215
Query: 599 PQP 601
P P
Sbjct: 216 PAP 218
>gi|39812378 RAN binding protein 9 [Homo sapiens]
Length = 729
Score = 57.8 bits (138), Expect = 5e-08
Identities = 36/99 (36%), Positives = 42/99 (42%), Gaps = 18/99 (18%)
Query: 516 TGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPP--------GGPPT 567
+ P SP G L ++ L PPPPP P PPPPPPP PP GPP
Sbjct: 45 SSPAGSPGGGAGGEGLGAAAAALLLHPPPPPPPATAAPPPPPPPPPPPASAAAPASGPPA 104
Query: 568 PPG--APPCLGMGLPLP--------QDPYPSSDVPLRKK 596
PPG A P G P P P+P D L ++
Sbjct: 105 PPGLAAGPGPAGGAPTPALVAGSSAAAPFPHGDSALNEQ 143
Score = 31.2 bits (69), Expect = 5.5
Identities = 30/110 (27%), Positives = 33/110 (30%), Gaps = 32/110 (29%)
Query: 519 VSSPPPPGGPLTLSSSMTTNDLPPPPP----PLPFACCPPPPP------PPLPPGG---- 564
+S PPP P L PPPP P+ P PP P PGG
Sbjct: 1 MSGQPPPPPP---QQQQQQQQLSPPPPAALAPVSGVVLPAPPAVSAGSSPAGSPGGGAGG 57
Query: 565 -------------PPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQP 601
PP PP PP P P P P + P P
Sbjct: 58 EGLGAAAAALLLHPPPPP--PPATAAPPPPPPPPPPPASAAAPASGPPAP 105
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 57.8 bits (138), Expect = 5e-08
Identities = 31/60 (51%), Positives = 35/60 (58%), Gaps = 2/60 (3%)
Query: 512 SELSTGP--VSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPP 569
S+L +G VSS P P SSS+ + PPPPPP P PPPPPPP PP PPT P
Sbjct: 2374 SQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSP 2433
Score = 41.2 bits (95), Expect = 0.005
Identities = 28/76 (36%), Positives = 34/76 (44%), Gaps = 11/76 (14%)
Query: 532 SSSMTTNDLPPPPPP------LPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDP 585
S S + + LP P P L + PPPPPP PP PP PP LP P P
Sbjct: 2378 SGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPP----PPPPPPPPPPPPPPPPLPPPTSP 2433
Query: 586 YPSSDVPLRKKRVPQP 601
P+ +P +K V P
Sbjct: 2434 KPTI-LPKKKLTVASP 2448
Score = 38.1 bits (87), Expect = 0.045
Identities = 31/93 (33%), Positives = 35/93 (37%), Gaps = 13/93 (13%)
Query: 517 GPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPG---GPPTPPGA-- 571
GP P GP S+ T PP P P PPP PG PP PG+
Sbjct: 445 GPGKIPAQQAGPGKTSAQQTGPTKPPSQLP------GPAKPPPQQPGPAKPPPQQPGSAK 498
Query: 572 PPCL--GMGLPLPQDPYPSSDVPLRKKRVPQPS 602
PP G P PQ P P+ P + PS
Sbjct: 499 PPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPS 531
Score = 33.9 bits (76), Expect = 0.84
Identities = 15/31 (48%), Positives = 17/31 (54%), Gaps = 1/31 (3%)
Query: 553 PPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQ 583
P P P+P G P TPPG P G +P PQ
Sbjct: 864 PKPDAKPMPKGSP-TPPGPRPTAGQTVPTPQ 893
Score = 32.7 bits (73), Expect = 1.9
Identities = 22/72 (30%), Positives = 24/72 (33%), Gaps = 9/72 (12%)
Query: 517 GPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLG 576
GP PP G S + PPP P P P P PG P P G
Sbjct: 485 GPAKPPPQQPGSAKPPSQQPGSTKPPPQQP------GPAKPSPQQPGSTKPPSQQP---G 535
Query: 577 MGLPLPQDPYPS 588
P Q P P+
Sbjct: 536 SAKPSAQQPSPA 547
Score = 30.8 bits (68), Expect = 7.1
Identities = 27/76 (35%), Positives = 28/76 (36%), Gaps = 12/76 (15%)
Query: 540 LPPPPPPLPFACCPPPPPPPLPPG------GPPTPPGAPPCLGMGLPLPQDP---YPSSD 590
LP P P P P PP PG GP PP P G+ PL Q P P
Sbjct: 298 LPSPSKP-PIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPS--GLTKPLAQQPGTVKPPVQ 354
Query: 591 VPLRKKRVPQPSHPLK 606
P K QP P K
Sbjct: 355 PPGTTKPPAQPLGPAK 370
Score = 30.4 bits (67), Expect = 9.3
Identities = 29/94 (30%), Positives = 33/94 (35%), Gaps = 13/94 (13%)
Query: 518 PVSSPPPPGGPLTLSSSMTTNDLPPPPPPL-------PFACCPPPPPPPLPPGGPPTPPG 570
P P PG P + P PP P A P PP+ P G PP
Sbjct: 304 PPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA 363
Query: 571 APPCLGMGLPLPQ---DPYPSSDVPLRKKRVPQP 601
P LG P Q PSS+ P K + QP
Sbjct: 364 QP--LGPAKPPAQQTGSEKPSSEQP-GPKALAQP 394
Score = 30.4 bits (67), Expect = 9.3
Identities = 22/71 (30%), Positives = 26/71 (36%), Gaps = 4/71 (5%)
Query: 517 GPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPP--PPPLPPGGPPTPPGAPPC 574
G P P GP + T ++ P P P A PP P GP PP
Sbjct: 357 GTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQ-- 414
Query: 575 LGMGLPLPQDP 585
+G PL Q P
Sbjct: 415 VGTPKPLAQQP 425
Score = 30.4 bits (67), Expect = 9.3
Identities = 27/125 (21%), Positives = 43/125 (34%), Gaps = 17/125 (13%)
Query: 495 QELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLT-------------LSSSMTTNDLP 541
Q+ + + Q L ++ P S P P +T S+ ++T P
Sbjct: 893 QQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQP 952
Query: 542 PPP----PPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKR 597
P P P P P PP G P + APP +P+ ++ + L K
Sbjct: 953 GPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKA 1012
Query: 598 VPQPS 602
P+
Sbjct: 1013 EQAPT 1017
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 57.8 bits (138), Expect = 5e-08
Identities = 31/60 (51%), Positives = 35/60 (58%), Gaps = 2/60 (3%)
Query: 512 SELSTGP--VSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPP 569
S+L +G VSS P P SSS+ + PPPPPP P PPPPPPP PP PPT P
Sbjct: 2374 SQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSP 2433
Score = 41.2 bits (95), Expect = 0.005
Identities = 28/76 (36%), Positives = 34/76 (44%), Gaps = 11/76 (14%)
Query: 532 SSSMTTNDLPPPPPP------LPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDP 585
S S + + LP P P L + PPPPPP PP PP PP LP P P
Sbjct: 2378 SGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPP----PPPPPPPPPPPPPPPPLPPPTSP 2433
Query: 586 YPSSDVPLRKKRVPQP 601
P+ +P +K V P
Sbjct: 2434 KPTI-LPKKKLTVASP 2448
Score = 38.1 bits (87), Expect = 0.045
Identities = 31/93 (33%), Positives = 35/93 (37%), Gaps = 13/93 (13%)
Query: 517 GPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPG---GPPTPPGA-- 571
GP P GP S+ T PP P P PPP PG PP PG+
Sbjct: 445 GPGKIPAQQAGPGKTSAQQTGPTKPPSQLP------GPAKPPPQQPGPAKPPPQQPGSAK 498
Query: 572 PPCL--GMGLPLPQDPYPSSDVPLRKKRVPQPS 602
PP G P PQ P P+ P + PS
Sbjct: 499 PPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPS 531
Score = 33.9 bits (76), Expect = 0.84
Identities = 15/31 (48%), Positives = 17/31 (54%), Gaps = 1/31 (3%)
Query: 553 PPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQ 583
P P P+P G P TPPG P G +P PQ
Sbjct: 864 PKPDAKPMPKGSP-TPPGPRPTAGQTVPTPQ 893
Score = 32.7 bits (73), Expect = 1.9
Identities = 22/72 (30%), Positives = 24/72 (33%), Gaps = 9/72 (12%)
Query: 517 GPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLG 576
GP PP G S + PPP P P P P PG P P G
Sbjct: 485 GPAKPPPQQPGSAKPPSQQPGSTKPPPQQP------GPAKPSPQQPGSTKPPSQQP---G 535
Query: 577 MGLPLPQDPYPS 588
P Q P P+
Sbjct: 536 SAKPSAQQPSPA 547
Score = 30.8 bits (68), Expect = 7.1
Identities = 27/76 (35%), Positives = 28/76 (36%), Gaps = 12/76 (15%)
Query: 540 LPPPPPPLPFACCPPPPPPPLPPG------GPPTPPGAPPCLGMGLPLPQDP---YPSSD 590
LP P P P P PP PG GP PP P G+ PL Q P P
Sbjct: 298 LPSPSKP-PIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPS--GLTKPLAQQPGTVKPPVQ 354
Query: 591 VPLRKKRVPQPSHPLK 606
P K QP P K
Sbjct: 355 PPGTTKPPAQPLGPAK 370
Score = 30.4 bits (67), Expect = 9.3
Identities = 29/94 (30%), Positives = 33/94 (35%), Gaps = 13/94 (13%)
Query: 518 PVSSPPPPGGPLTLSSSMTTNDLPPPPPPL-------PFACCPPPPPPPLPPGGPPTPPG 570
P P PG P + P PP P A P PP+ P G PP
Sbjct: 304 PPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA 363
Query: 571 APPCLGMGLPLPQ---DPYPSSDVPLRKKRVPQP 601
P LG P Q PSS+ P K + QP
Sbjct: 364 QP--LGPAKPPAQQTGSEKPSSEQP-GPKALAQP 394
Score = 30.4 bits (67), Expect = 9.3
Identities = 22/71 (30%), Positives = 26/71 (36%), Gaps = 4/71 (5%)
Query: 517 GPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPP--PPPLPPGGPPTPPGAPPC 574
G P P GP + T ++ P P P A PP P GP PP
Sbjct: 357 GTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQ-- 414
Query: 575 LGMGLPLPQDP 585
+G PL Q P
Sbjct: 415 VGTPKPLAQQP 425
Score = 30.4 bits (67), Expect = 9.3
Identities = 27/125 (21%), Positives = 43/125 (34%), Gaps = 17/125 (13%)
Query: 495 QELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLT-------------LSSSMTTNDLP 541
Q+ + + Q L ++ P S P P +T S+ ++T P
Sbjct: 893 QQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQP 952
Query: 542 PPP----PPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKR 597
P P P P P PP G P + APP +P+ ++ + L K
Sbjct: 953 GPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKA 1012
Query: 598 VPQPS 602
P+
Sbjct: 1013 EQAPT 1017
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 57.8 bits (138), Expect = 5e-08
Identities = 47/147 (31%), Positives = 66/147 (44%), Gaps = 17/147 (11%)
Query: 491 ARESQELRQARGQVAELVAQLSELSTGPVSS---PPP----PGGPLTLSSSMTTNDLPPP 543
+ + E +Q+ G+ E+ E+ + P++S P P PG + S+ LP P
Sbjct: 625 SEKMDEGQQSSGEDMEISDD--EMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLP 682
Query: 544 PPPLPFACCPPPPPPPLP-PGGP-----PTPPGAPPCLGMGLPLPQDPYPS-SDVPLRKK 596
PPP F PPPPPPP P PG P P PP PP + +P P P+ VP
Sbjct: 683 PPP-GFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPI 741
Query: 597 RVPQPSHPLKSFNWVKLNEERVPGTVW 623
P P P F ++++ V G W
Sbjct: 742 LPPLPPFPPGLFPVMQVDMSHVLGGQW 768
Score = 44.3 bits (103), Expect = 6e-04
Identities = 41/138 (29%), Positives = 53/138 (38%), Gaps = 30/138 (21%)
Query: 523 PPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPP------------TPPG 570
P P T++ +P PPPPLP PPPPPPP+ P P PPG
Sbjct: 1519 PSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPG 1578
Query: 571 APPCLGMGLPLPQDPYPSSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQ 630
P +D + L K R P P K +E+ VP E+ Q
Sbjct: 1579 ---------PRGRDEVTEEYMELAKSRGPWRRPPKKR------HEDLVPPAGSPELSPPQ 1623
Query: 631 -VFRILDLEDFEKMFSAY 647
+FR +FE+M Y
Sbjct: 1624 PLFR--PRSEFEEMTILY 1639
Score = 41.6 bits (96), Expect = 0.004
Identities = 42/119 (35%), Positives = 48/119 (40%), Gaps = 27/119 (22%)
Query: 514 LSTG-PVSSPPPPGGPLTLSSSMTTNDLPPPP-PPL---PFACCPPP-----------PP 557
L TG P+ P P PL L + + P P PPL P A CPPP PP
Sbjct: 1425 LETGLPLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPP 1484
Query: 558 PPLPPGGPPTPPGAPPCLGMGLPL----PQDP-YPSSDVP------LRKKRVPQPSHPL 605
L GP P A LG L L PQ P +PS+ P R +P P PL
Sbjct: 1485 SMLSLDGPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPL 1543
Score = 39.3 bits (90), Expect = 0.020
Identities = 26/73 (35%), Positives = 27/73 (36%), Gaps = 17/73 (23%)
Query: 518 PVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCP-----------PPPPPPLPPGGP- 565
P + P PG S T PPPP P A P PPPLPP P
Sbjct: 384 PAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPL 443
Query: 566 -----PTPPGAPP 573
TPPG PP
Sbjct: 444 AKEKPGTPPGPPP 456
Score = 38.1 bits (87), Expect = 0.045
Identities = 44/149 (29%), Positives = 56/149 (37%), Gaps = 27/149 (18%)
Query: 453 KEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLS 512
K H L SR+E +E TK L E EL+ ++ +QLS
Sbjct: 494 KPHDSLDSRIEMLLKEQRTKLLFLRE------------PDSDTELQMEGSPISSSSSQLS 541
Query: 513 ELSTGPVSSPPPPGGPLTLSS---SMTTNDLPPPPPP-------LPFACCPPPPPPPLPP 562
L+ +S P GP SS S D+ P P P L P PPP P
Sbjct: 542 PLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGLGPRPPPEP--- 598
Query: 563 GGPPTPPG-APPCLGMGLPLPQDPYPSSD 590
GPP P G + L L D P+S+
Sbjct: 599 -GPPDPAGLLSQTAEVALDLVGDRTPTSE 626
Score = 37.7 bits (86), Expect = 0.058
Identities = 28/84 (33%), Positives = 32/84 (38%), Gaps = 22/84 (26%)
Query: 521 SPPPPGGPLTLSSSMTTNDLP-------PPPP---PLPFACCPPPPPPPLPPGGPPTP-- 568
SP PP + ++ P P PP PLP PPP PP PP PP P
Sbjct: 1240 SPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPET 1299
Query: 569 -----PGAPPCLGMGLPLPQDPYP 587
P PP PL +D P
Sbjct: 1300 TDASHPSVPP-----EPLAEDHPP 1318
Score = 35.0 bits (79), Expect = 0.38
Identities = 33/101 (32%), Positives = 35/101 (34%), Gaps = 16/101 (15%)
Query: 518 PVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPL---------PPGGPPTP 568
P+ P PP P TT+ P PP P A PP P L P TP
Sbjct: 1281 PLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATP 1340
Query: 569 PGAPPCLG--MGLPLPQDPYPSSDVPLRKKRVPQPSHPLKS 607
G PP G GL L P S P PS L S
Sbjct: 1341 GGEPPLSGGSSGLSLSSPQVPGSPF-----SYPAPSPSLSS 1376
Score = 33.5 bits (75), Expect = 1.1
Identities = 29/87 (33%), Positives = 32/87 (36%), Gaps = 3/87 (3%)
Query: 522 PPPPGGPLTLSSSMTTNDLPPPP-PPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLP 580
P PGG LS + L P P PF+ P P P L GG P PG
Sbjct: 1337 PATPGGEPPLSGGSSGLSLSSPQVPGSPFSY--PAPSPSLSSGGLPRTPGRDFSFTPTFS 1394
Query: 581 LPQDPYPSSDVPLRKKRVPQPSHPLKS 607
P P PL R + S PL S
Sbjct: 1395 EPSGPLLLPVCPLPTGRRDERSGPLAS 1421
Score = 33.1 bits (74), Expect = 1.4
Identities = 20/53 (37%), Positives = 21/53 (39%), Gaps = 7/53 (13%)
Query: 518 PVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPG 570
P+ P PP P S PPP P A P PP PL PP PG
Sbjct: 1277 PLQPPLPPPRPPRPPS-------PPPEPETTDASHPSVPPEPLAEDHPPHTPG 1322
Score = 32.3 bits (72), Expect = 2.4
Identities = 25/80 (31%), Positives = 27/80 (33%), Gaps = 27/80 (33%)
Query: 518 PVSSPPPPGGP-LTLSSSMTTNDLPPPPPPLPFACCPP---------------------- 554
P S PP P L+ +M L P PP PP
Sbjct: 1219 PADSREPPEEPGLSQEGAML---LSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLP 1275
Query: 555 -PPPPPLPPGGPPTPPGAPP 573
P PPLPP PP PP PP
Sbjct: 1276 LPLQPPLPPPRPPRPPSPPP 1295
Score = 32.0 bits (71), Expect = 3.2
Identities = 27/86 (31%), Positives = 31/86 (36%), Gaps = 20/86 (23%)
Query: 513 ELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAP 572
E P P PP PL P PP P PPP + GG PT +P
Sbjct: 427 EFRRAPAPPPLPPAEPLAKEK--------PGTPPGP----PPPDTNSMELGGRPTFGWSP 474
Query: 573 -PCLGMGLPL-------PQDPYPSSD 590
PC G P P+ P+ S D
Sbjct: 475 EPCDSPGTPTLESSPAGPEKPHDSLD 500
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 57.4 bits (137), Expect = 7e-08
Identities = 37/89 (41%), Positives = 38/89 (42%), Gaps = 18/89 (20%)
Query: 520 SSPPPP-----GGPLTLSSSMTTNDLPPPPPPLPFACCPPPPP-----PPLP------PG 563
S PPPP G P S T PPPPP P PPPPP PP P P
Sbjct: 297 SGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPS 356
Query: 564 GPPTPPGAPPCLGMGLPLPQDPYPSSDVP 592
GPP PP P LG+G P P P P
Sbjct: 357 GPPPPP--PSVLGVGPVAPPPPPPPPPPP 383
Score = 56.6 bits (135), Expect = 1e-07
Identities = 29/69 (42%), Positives = 31/69 (44%), Gaps = 18/69 (26%)
Query: 522 PPPPGGPLTLSSSMTTNDL-PPPPPPLPFAC-----------------CPPPPPPPLPPG 563
PPPP P N + PPPPP LP + PPPPPPP PP
Sbjct: 324 PPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPP 383
Query: 564 GPPTPPGAP 572
GPP PPG P
Sbjct: 384 GPPPPPGLP 392
Score = 52.0 bits (123), Expect = 3e-06
Identities = 29/88 (32%), Positives = 34/88 (38%), Gaps = 12/88 (13%)
Query: 517 GPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLG 576
GP PPPP ++ PPPPP PPPPP P PP PP + P +
Sbjct: 286 GPPPPPPPP------------HNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVA 333
Query: 577 MGLPLPQDPYPSSDVPLRKKRVPQPSHP 604
+ P P YP L P P
Sbjct: 334 VPPPPPNRMYPPPPPALPSSAPSGPPPP 361
Score = 50.4 bits (119), Expect = 9e-06
Identities = 28/62 (45%), Positives = 28/62 (45%), Gaps = 8/62 (12%)
Query: 543 PPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQPS 602
PPPP P PPPPPPP GPP PP G G P P P S P P PS
Sbjct: 277 PPPPPPSRGGPPPPPPPPHNSGPPPPPAR----GRGAP----PPPPSRAPTAAPPPPPPS 328
Query: 603 HP 604
P
Sbjct: 329 RP 330
Score = 48.5 bits (114), Expect = 3e-05
Identities = 32/88 (36%), Positives = 34/88 (38%), Gaps = 16/88 (18%)
Query: 522 PPPP--GGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGL 579
PPPP GGP PPPPP P PPPPP G PP PP P
Sbjct: 279 PPPPSRGGP-------------PPPPPPPHNS-GPPPPPARGRGAPPPPPSRAPTAAPPP 324
Query: 580 PLPQDPYPSSDVPLRKKRVPQPSHPLKS 607
P P P + P + P P L S
Sbjct: 325 PPPSRPSVAVPPPPPNRMYPPPPPALPS 352
Score = 43.5 bits (101), Expect = 0.001
Identities = 24/55 (43%), Positives = 25/55 (45%), Gaps = 6/55 (10%)
Query: 515 STGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPP 569
S+ P PPPP P L PPPPPP P PPPPP LP G P
Sbjct: 352 SSAPSGPPPPP--PSVLGVGPVAPPPPPPPPPPP----GPPPPPGLPSDGDHQVP 400
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,464,722
Number of Sequences: 37866
Number of extensions: 2643658
Number of successful extensions: 59342
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 802
Number of HSP's successfully gapped in prelim test: 1223
Number of HSP's that attempted gapping in prelim test: 22280
Number of HSP's gapped (non-prelim): 17775
length of query: 1067
length of database: 18,247,518
effective HSP length: 113
effective length of query: 954
effective length of database: 13,968,660
effective search space: 13326101640
effective search space used: 13326101640
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.