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Search of human proteins with 12545408
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
(849 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 1715 0.0
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 1058 0.0
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 335 1e-91
gi|4759026 RAS protein activator like 1 [Homo sapiens] 305 1e-82
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 300 5e-81
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 300 5e-81
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 296 4e-80
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 293 4e-79
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 293 4e-79
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 122 1e-27
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 122 1e-27
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 118 2e-26
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 118 2e-26
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 113 8e-25
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 113 8e-25
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 112 1e-24
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 100 4e-21
gi|130502162 RAS protein activator like 3 [Homo sapiens] 97 5e-20
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 89 2e-17
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 73 1e-12
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 73 1e-12
gi|211059429 synaptotagmin II [Homo sapiens] 69 2e-11
gi|31543670 synaptotagmin II [Homo sapiens] 69 2e-11
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 69 2e-11
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 68 4e-11
gi|14249614 synaptotagmin-like 1 [Homo sapiens] 67 7e-11
gi|209447073 synaptotagmin I [Homo sapiens] 63 1e-09
gi|5032139 synaptotagmin I [Homo sapiens] 63 1e-09
gi|209447070 synaptotagmin I [Homo sapiens] 63 1e-09
gi|92859638 synaptotagmin V [Homo sapiens] 62 2e-09
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 1715 bits (4441), Expect = 0.0
Identities = 849/849 (100%), Positives = 849/849 (100%)
Query: 1 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR 60
MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR
Sbjct: 1 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR 60
Query: 61 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK 120
DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK
Sbjct: 61 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK 120
Query: 121 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC 180
VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC
Sbjct: 121 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC 180
Query: 181 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ 240
HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ
Sbjct: 181 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ 240
Query: 241 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS 300
FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS
Sbjct: 241 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS 300
Query: 301 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA 360
SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA
Sbjct: 301 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA 360
Query: 361 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV 420
VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV
Sbjct: 361 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV 420
Query: 421 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD 480
TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD
Sbjct: 421 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD 480
Query: 481 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL 540
IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL
Sbjct: 481 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL 540
Query: 541 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT 600
ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT
Sbjct: 541 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT 600
Query: 601 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAV 660
SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAV
Sbjct: 601 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAV 660
Query: 661 EKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYL 720
EKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYL
Sbjct: 661 EKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYL 720
Query: 721 NGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACG 780
NGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACG
Sbjct: 721 NGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACG 780
Query: 781 TIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSK 840
TIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSK
Sbjct: 781 TIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSK 840
Query: 841 ENPIVGKAS 849
ENPIVGKAS
Sbjct: 841 ENPIVGKAS 849
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 1058 bits (2736), Expect = 0.0
Identities = 503/817 (61%), Positives = 651/817 (79%), Gaps = 8/817 (0%)
Query: 34 VRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYF 93
+RV QS++ KI EAKNL Y GP KMRDC+CT+NLDQEEV+RT++VEKSL PF+ E+FY
Sbjct: 8 LRVFQSVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYC 67
Query: 94 EIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKV 153
EIPR+F++LSFY++D++V +RD IGKVAI+KEDL + ++TWF LQ VD++SEVQGKV
Sbjct: 68 EIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADSEVQGKV 127
Query: 154 HLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVK 213
HLEL+L+E+IT+ G VC +L I C GLP++NGQ CDPYATV+L GP R++ KKTKVK
Sbjct: 128 HLELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQ-CDPYATVTLAGPFRSEAKKTKVK 186
Query: 214 KKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNL-VQDVFLGEI 272
+KT+NPQF+E+FYFEVTR SY++KS F EEED++KLEIR+DLWN NL D FLGE+
Sbjct: 187 RKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGEL 246
Query: 273 KVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTL 332
++P+ VLR SS++AWY LQPRDNG+KS K DDLGSLRLN+ YTED+V S+YY PL+ L
Sbjct: 247 RIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDL 306
Query: 333 LLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDA 392
LLKS DV+P+SASAA+IL E+CR+K +A +PLVRL LH+ ++VPF +A+A ++K TQD
Sbjct: 307 LLKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDP 366
Query: 393 NTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENN 452
NTIFRGNSLA++C+DE MK+ G HYL VTLKP ++EIC S K CEIDP+KLK+G+N+ENN
Sbjct: 367 NTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGENLENN 426
Query: 453 KENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRF 512
ENLR YVD++F+ I +S +SCPTVMCDIF+SLR+ A +RF +DP V+Y+AVSSF+FLRF
Sbjct: 427 MENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLRF 486
Query: 513 FAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKS-SFKETFMCEFFK 571
FA A++SP+ F L PHH D QT RTLTLISKT+QTL GSLSKSKS SFKE++M F++
Sbjct: 487 FAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTL---GSLSKSKSASFKESYMATFYE 543
Query: 572 MFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNFKKRWF 631
F E+ Y AVK FLD ISS+ ++ +P+ LKEG M KRAQGR R G KNFKKRWF
Sbjct: 544 FFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRAQGRKRFGMKNFKKRWF 603
Query: 632 CLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKPLYVQANNCV 691
LT+ E TYHK G +Y+IP++NILAVEKLEE SF KNMFQVI E+ LY+QANNCV
Sbjct: 604 RLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYIQANNCV 663
Query: 692 EANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLGCKPCTAGVPADIQID 751
EA +WID+L +VS+CNQ RL+ YHPS YL+G+WLCC+ ++ GC PCT G+PA+IQ+D
Sbjct: 664 EAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGCSPCTGGLPANIQLD 723
Query: 752 IDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQ 811
ID DRETERIYSLF L + KL+KM+EACG+ +VY GP++E +YS FVI+D T+KT++
Sbjct: 724 IDGDRETERIYSLFNLYMSKLEKMQEACGSKSVYDGPEQE--EYSTFVIDDPQETYKTLK 781
Query: 812 QIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKA 848
Q+ + + L++ H +Y++ + KYGS+E+PI K+
Sbjct: 782 QVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKS 818
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 335 bits (859), Expect = 1e-91
Identities = 237/792 (29%), Positives = 386/792 (48%), Gaps = 66/792 (8%)
Query: 39 SLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRT 98
SL +I E KNL P D +C + +D E + RT V K+L PF+ EE+ +P T
Sbjct: 6 SLYIRIVEGKNL-PAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
Query: 99 FQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNH-SGKETWFSLQPVDSNSEVQGKVHLEL 157
F ++FYV D++ L RD IGKV + ++ + +H G W L VD + EVQG++HL L
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRL 124
Query: 158 KLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTS 217
+ + C+ ++A P + DP+ V G +R +T + KK+
Sbjct: 125 E----VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR----ETSIVKKSC 176
Query: 218 NPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVN 277
P++NE F +F+++E +E L ++ W+ + ++ FLG++ + V
Sbjct: 177 YPRWNETF--------------EFELQEGAMEAL--CVEAWDWDLVSRNDFLGKVVIDVQ 220
Query: 278 VLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSP 337
LR + W+ LQP + ++ +LGSL+L + ++ VLPS YY PL LL
Sbjct: 221 RLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEV 280
Query: 338 DVQPISASAAYILSEICRD---KNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANT 394
+ L E + D L++L L F + +L+L T + NT
Sbjct: 281 KLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNT 340
Query: 395 IFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK---------- 444
+FR NSLA++ ++ +K+ G YL L PI++++ + K E+DP K++
Sbjct: 341 LFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLH 400
Query: 445 ----EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH-- 498
E + +E + + LR ++ L + + +S +CP V+ F L + +RFP H
Sbjct: 401 RPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHEN 460
Query: 499 VQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSK 558
V + AV+SF+ LRFF+ A++SP FHLR H DA+T RTL L++K +Q + G++
Sbjct: 461 VPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNV---GNMDTPA 517
Query: 559 SSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHL-----KEGEMY- 612
S KE +M E + +G + +K F+ ++ E K+ + L KEG ++
Sbjct: 518 SRAKEAWM-EPLQPTVRQG-VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFI 575
Query: 613 KRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKN 672
R +G+ + +FKK +F LT+ L++ K P I + NI A EK+EE SF +
Sbjct: 576 HRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSH 635
Query: 673 MFQVIHTE-----KPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCC 727
+ QVI+T+ + Y+Q E N+W+ L +VS N L YHP V+ W CC
Sbjct: 636 VMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCC 695
Query: 728 QETGENTLGCKPCTAGVPADIQID-IDEDRETERI-YSLFTLSLLKLQKMEEACGTI--- 782
+ + GC + V D +D D E + I L + + ++ E G
Sbjct: 696 HQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAG 755
Query: 783 AVYQGPQKEPDD 794
V P K P+D
Sbjct: 756 TVPTSPGKVPED 767
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 305 bits (781), Expect = 1e-82
Identities = 232/837 (27%), Positives = 395/837 (47%), Gaps = 79/837 (9%)
Query: 39 SLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRT 98
SL ++ E + LP D +C + +D E V RT V +SL PF+ EE+ +P
Sbjct: 6 SLNVRVVEGR-ALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLD 64
Query: 99 FQYLSFYVYDKNVLQRDLRIGKVAIKKEDL-CNHSGKETWFSLQPVDSNSEVQGKVHLEL 157
F L+FYV D++ + D IGK+++ +E + + G ++W +L VD ++EVQG++ L +
Sbjct: 65 FHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSV 124
Query: 158 KLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTS 217
++ E G + V+H + P + DP+A V S +T KKT
Sbjct: 125 QMLE--DGQGRCLRCHVLHARDL--APRDISGTSDPFARVFWGSQS----LETSTIKKTR 176
Query: 218 NPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVN 277
P ++E+ ++ E +R++LW+ + ++ FLG ++
Sbjct: 177 FPHWDEV----------------LELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPK 220
Query: 278 VLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSP 337
L+ + W+ L P + S +LG+LR+ + ED VLPS+ Y PL LL++S
Sbjct: 221 TLQ-QKPPKGWFRLLPFPRAEEDS-GGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESV 278
Query: 338 D--VQPISASAAYILSEI----CRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQD 391
+ +AS +L E+ CR D LV+L L F + ++ T D
Sbjct: 279 QGPAEEDTASPLALLEELTLGDCR--QDLATKLVKLFLGRGLAGHFLDYLTRREVARTMD 336
Query: 392 ANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIK--------- 442
NT+FR NSLA++ +++ MK+VG YL LKP++ + + K E+DP K
Sbjct: 337 PNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRI 396
Query: 443 -----LKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDP 497
L E E + L Y+ + + IV S CP M F L + +RFP
Sbjct: 397 SFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAE 456
Query: 498 H--VQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS 555
H V+Y A+S F+FLRFFA A+++P F LR H D QT R+L L++K +Q++ G+L
Sbjct: 457 HQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSI---GNLG 513
Query: 556 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVH-----LKEGE 610
+ KE +M + + V+ FLD + + E+ + + ++EG
Sbjct: 514 QQLGQGKELWMAPLHPFLLQ--CVSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGY 571
Query: 611 MYKRAQGRTRIGKK-NFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFN 669
+ KR + + + FKKR+ L+ L++ K P ++IPV +I AVE+++E +F
Sbjct: 572 LLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQ 631
Query: 670 KKNMFQVIHTE-----KPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNW 724
++ QV+ + Y+Q N E N+W+ L + S N N+L+ HP + + W
Sbjct: 632 LPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARW 691
Query: 725 LCCQETGENTLGCKPCTAGVP-ADIQIDIDEDRETERIYSLFTL--SLLKLQKMEEACGT 781
CC + + GC + V D +D D E + +Y L L+L+ +E++
Sbjct: 692 TCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMD 751
Query: 782 IAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYG 838
+ P+ + T + ++ ++ LD HE+++++ A G
Sbjct: 752 TTLEADTGACPE----VLARQRAATARLLE----VLADLDRAHEEFQQQERGKAALG 800
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 300 bits (767), Expect = 5e-81
Identities = 224/788 (28%), Positives = 367/788 (46%), Gaps = 104/788 (13%)
Query: 39 SLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRT 98
SL +I E KNL P D +C + +D E + RT V K+L PF+ EE+ +P T
Sbjct: 6 SLYIRIVEGKNL-PAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
Query: 99 FQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNH-SGKETWFSLQPVDSNSEVQGKVHLEL 157
F ++FYV D++ L RD IGKV + ++ + +H G W L VD + EVQG++HL L
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRL 124
Query: 158 KLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTS 217
+ + C+ ++A P + DP+ V G +R +T + KK+
Sbjct: 125 E----VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR----ETSIVKKSC 176
Query: 218 NPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVN 277
P++NE F +F+++E +E L ++ W+ + ++ FLG++ + V
Sbjct: 177 YPRWNETF--------------EFELQEGAMEAL--CVEAWDWDLVSRNDFLGKVVIDVQ 220
Query: 278 VLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSP 337
LR + W+ LQP + ++ +LGSL+L + ++ VLPS YY PL LL
Sbjct: 221 RLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEV 280
Query: 338 DVQPISASAAYILSEICRD---KNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANT 394
+ L E + D L++L L F + +L+L T + NT
Sbjct: 281 KLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNT 340
Query: 395 IFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK---------- 444
+FR NSLA++ ++ +K+ G YL L PI++++ + K E+DP K++
Sbjct: 341 LFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLH 400
Query: 445 ----EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH-- 498
E + +E + + LR ++ L + + +S +CP V+ F L + +RFP H
Sbjct: 401 RPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHEN 460
Query: 499 VQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSK 558
V + AV+SF+ LRFF+ A++SP FHLR H DA+T RTL L++K +Q + G++
Sbjct: 461 VPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNV---GNMDTPA 517
Query: 559 SSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHL-----KEGEMY- 612
S KE +M E + +G + +K F+ ++ E K+ + L KEG ++
Sbjct: 518 SRAKEAWM-EPLQPTVHQG-VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFI 575
Query: 613 KRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKN 672
R +G+ + +FKK +F LT+ L++ K P
Sbjct: 576 HRTKGKGPLMSSSFKKLYFSLTTEALSFAKTP---------------------------- 607
Query: 673 MFQVIHTEKPLYVQANNCV-EANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETG 731
++ CV E N+W+ L +VS N L YHP V+ W CC +
Sbjct: 608 --------------SSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKE 653
Query: 732 ENTLGCKPCTAGVPADIQID-IDEDRETERIY-SLFTLSLLKLQKMEEACGTI---AVYQ 786
+ GC + V D +D D E + IY L + + ++ E G V
Sbjct: 654 KTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPT 713
Query: 787 GPQKEPDD 794
P K P+D
Sbjct: 714 SPGKVPED 721
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 300 bits (767), Expect = 5e-81
Identities = 224/788 (28%), Positives = 367/788 (46%), Gaps = 104/788 (13%)
Query: 39 SLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRT 98
SL +I E KNL P D +C + +D E + RT V K+L PF+ EE+ +P T
Sbjct: 6 SLYIRIVEGKNL-PAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
Query: 99 FQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNH-SGKETWFSLQPVDSNSEVQGKVHLEL 157
F ++FYV D++ L RD IGKV + ++ + +H G W L VD + EVQG++HL L
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRL 124
Query: 158 KLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTS 217
+ + C+ ++A P + DP+ V G +R +T + KK+
Sbjct: 125 E----VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR----ETSIVKKSC 176
Query: 218 NPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVN 277
P++NE F +F+++E +E L ++ W+ + ++ FLG++ + V
Sbjct: 177 YPRWNETF--------------EFELQEGAMEAL--CVEAWDWDLVSRNDFLGKVVIDVQ 220
Query: 278 VLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSP 337
LR + W+ LQP + ++ +LGSL+L + ++ VLPS YY PL LL
Sbjct: 221 RLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEV 280
Query: 338 DVQPISASAAYILSEICRD---KNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANT 394
+ L E + D L++L L F + +L+L T + NT
Sbjct: 281 KLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNT 340
Query: 395 IFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK---------- 444
+FR NSLA++ ++ +K+ G YL L PI++++ + K E+DP K++
Sbjct: 341 LFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLH 400
Query: 445 ----EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH-- 498
E + +E + + LR ++ L + + +S +CP V+ F L + +RFP H
Sbjct: 401 RPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHEN 460
Query: 499 VQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSK 558
V + AV+SF+ LRFF+ A++SP FHLR H DA+T RTL L++K +Q + G++
Sbjct: 461 VPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNV---GNMDTPA 517
Query: 559 SSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHL-----KEGEMY- 612
S KE +M E + +G + +K F+ ++ E K+ + L KEG ++
Sbjct: 518 SRAKEAWM-EPLQPTVHQG-VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFI 575
Query: 613 KRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKN 672
R +G+ + +FKK +F LT+ L++ K P
Sbjct: 576 HRTKGKGPLMSSSFKKLYFSLTTEALSFAKTP---------------------------- 607
Query: 673 MFQVIHTEKPLYVQANNCV-EANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETG 731
++ CV E N+W+ L +VS N L YHP V+ W CC +
Sbjct: 608 --------------SSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKE 653
Query: 732 ENTLGCKPCTAGVPADIQID-IDEDRETERIY-SLFTLSLLKLQKMEEACGTI---AVYQ 786
+ GC + V D +D D E + IY L + + ++ E G V
Sbjct: 654 KTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPT 713
Query: 787 GPQKEPDD 794
P K P+D
Sbjct: 714 SPGKVPED 721
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 296 bits (759), Expect = 4e-80
Identities = 223/788 (28%), Positives = 366/788 (46%), Gaps = 104/788 (13%)
Query: 39 SLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRT 98
SL +I E KNL P D +C + +D E + RT V K+L PF+ EE+ +P T
Sbjct: 6 SLYIRIVEGKNL-PAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
Query: 99 FQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNH-SGKETWFSLQPVDSNSEVQGKVHLEL 157
F ++FYV D++ L RD IGKV + ++ + +H G W L VD + EVQG++HL L
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRL 124
Query: 158 KLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTS 217
+ + C+ ++A P + DP+ V G +R +T + KK+
Sbjct: 125 E----VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR----ETSIVKKSC 176
Query: 218 NPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVN 277
P++NE F +F+++E +E L ++ W+ + ++ FLG++ + V
Sbjct: 177 YPRWNETF--------------EFELQEGAMEAL--CVEAWDWDLVSRNDFLGKVVIDVQ 220
Query: 278 VLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSP 337
LR + W+ LQP + ++ +LGSL+L + ++ VLPS YY PL LL
Sbjct: 221 RLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEV 280
Query: 338 DVQPISASAAYILSEICRD---KNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANT 394
+ L E + D L++L L F + +L+L T + NT
Sbjct: 281 KLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNT 340
Query: 395 IFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK---------- 444
+FR NSLA++ ++ +K+ G YL L PI++++ + K E+DP K++
Sbjct: 341 LFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLH 400
Query: 445 ----EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH-- 498
E + +E + + LR ++ L + + +S +CP V+ F L + +RFP H
Sbjct: 401 RPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHEN 460
Query: 499 VQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSK 558
V + AV+SF+ LRFF+ A++SP FHLR H DA+T RTL L++K +Q + G++
Sbjct: 461 VPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNV---GNMDTPA 517
Query: 559 SSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHL-----KEGEMY- 612
S KE +M E + +G + +K F+ ++ E K+ + L KEG ++
Sbjct: 518 SRAKEAWM-EPLQPTVRQG-VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFI 575
Query: 613 KRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKN 672
R +G+ + +FKK +F LT+ L++ K P
Sbjct: 576 HRTKGKGPLMSSSFKKLYFSLTTEALSFAKTP---------------------------- 607
Query: 673 MFQVIHTEKPLYVQANNCV-EANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETG 731
++ CV E N+W+ L +VS N L YHP V+ W CC +
Sbjct: 608 --------------SSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKE 653
Query: 732 ENTLGCKPCTAGVPADIQID-IDEDRETERI-YSLFTLSLLKLQKMEEACGTI---AVYQ 786
+ GC + V D +D D E + I L + + ++ E G V
Sbjct: 654 KTGQGCDKTRSRVTLQEWNDPLDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPT 713
Query: 787 GPQKEPDD 794
P K P+D
Sbjct: 714 SPGKVPED 721
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 293 bits (751), Expect = 4e-79
Identities = 211/723 (29%), Positives = 349/723 (48%), Gaps = 65/723 (8%)
Query: 108 DKNVLQRDLRIGKVAIKKEDLCNH-SGKETWFSLQPVDSNSEVQGKVHLELKLNELITEN 166
D++ L RD IGKV + ++ + +H G W L VD + EVQG++HL L+ +
Sbjct: 2 DEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLE----VWPG 57
Query: 167 GTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFY 226
C+ ++A P + DP+ V G +R +T + KK+ P++NE F
Sbjct: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR----ETSIVKKSCYPRWNETF- 112
Query: 227 FEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQ 286
+F+++E +E L ++ W+ + ++ FLG++ + V LR +
Sbjct: 113 -------------EFELQEGAMEAL--CVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEE 157
Query: 287 AWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASA 346
W+ LQP + ++ +LGSL+L + ++ VLPS YY PL LL +
Sbjct: 158 GWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQ 217
Query: 347 AYILSEICRD---KNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLAT 403
L E + D L++L L F + +L+L T + NT+FR NSLA+
Sbjct: 218 LIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLAS 277
Query: 404 RCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK--------------EGDNV 449
+ ++ +K+ G YL L PI++++ + K E+DP K++ E + +
Sbjct: 278 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 337
Query: 450 ENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH--VQYSAVSSF 507
E + + LR ++ L + + +S +CP V+ F L + +RFP H V + AV+SF
Sbjct: 338 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 397
Query: 508 VFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMC 567
+ LRFF+ A++SP FHLR H DA+T RTL L++K +Q + G++ S KE +M
Sbjct: 398 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNV---GNMDTPASRAKEAWM- 453
Query: 568 EFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHL-----KEGEMY-KRAQGRTRI 621
E + +G + +K F+ ++ E K+ + L KEG ++ R +G+ +
Sbjct: 454 EPLQPTVHQG-VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPL 512
Query: 622 GKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTE- 680
+FKK +F LT+ L++ K P I + NI A EK+EE SF ++ QVI+T+
Sbjct: 513 MSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDD 572
Query: 681 ----KPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLG 736
+ Y+Q E N+W+ L +VS N L YHP V+ W CC + + G
Sbjct: 573 AGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQG 632
Query: 737 CKPCTAGVPADIQID-IDEDRETERIY-SLFTLSLLKLQKMEEACGTI---AVYQGPQKE 791
C + V D +D D E + IY L + + ++ E G V P K
Sbjct: 633 CDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKV 692
Query: 792 PDD 794
P+D
Sbjct: 693 PED 695
Score = 45.8 bits (107), Expect = 2e-04
Identities = 44/152 (28%), Positives = 71/152 (46%), Gaps = 10/152 (6%)
Query: 40 LRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPR-T 98
LR + EA++L P + D F + + T +V+KS P ++E F FE+
Sbjct: 63 LRCSVLEARDLAPK-DRNGTSDPFVRVRY-KGRTRETSIVKKSCYPRWNETFEFELQEGA 120
Query: 99 FQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQ-----GKV 153
+ L +D +++ R+ +GKV I + L +E WF LQP S S G +
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
Query: 154 HLELKLNELITENGTVCQQLVVHIKACHGLPL 185
LE++L + + Q L VH+ CH + L
Sbjct: 181 QLEVRLRDETVLPSSYYQPL-VHL-LCHEVKL 210
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 293 bits (751), Expect = 4e-79
Identities = 211/723 (29%), Positives = 349/723 (48%), Gaps = 65/723 (8%)
Query: 108 DKNVLQRDLRIGKVAIKKEDLCNH-SGKETWFSLQPVDSNSEVQGKVHLELKLNELITEN 166
D++ L RD IGKV + ++ + +H G W L VD + EVQG++HL L+ +
Sbjct: 2 DEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLE----VWPG 57
Query: 167 GTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFY 226
C+ ++A P + DP+ V G +R +T + KK+ P++NE F
Sbjct: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR----ETSIVKKSCYPRWNETF- 112
Query: 227 FEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQ 286
+F+++E +E L ++ W+ + ++ FLG++ + V LR +
Sbjct: 113 -------------EFELQEGAMEAL--CVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEE 157
Query: 287 AWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASA 346
W+ LQP + ++ +LGSL+L + ++ VLPS YY PL LL +
Sbjct: 158 GWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQ 217
Query: 347 AYILSEICRD---KNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLAT 403
L E + D L++L L F + +L+L T + NT+FR NSLA+
Sbjct: 218 LIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLAS 277
Query: 404 RCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK--------------EGDNV 449
+ ++ +K+ G YL L PI++++ + K E+DP K++ E + +
Sbjct: 278 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 337
Query: 450 ENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH--VQYSAVSSF 507
E + + LR ++ L + + +S +CP V+ F L + +RFP H V + AV+SF
Sbjct: 338 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 397
Query: 508 VFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMC 567
+ LRFF+ A++SP FHLR H DA+T RTL L++K +Q + G++ S KE +M
Sbjct: 398 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNV---GNMDTPASRAKEAWM- 453
Query: 568 EFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHL-----KEGEMY-KRAQGRTRI 621
E + +G + +K F+ ++ E K+ + L KEG ++ R +G+ +
Sbjct: 454 EPLQPTVHQG-VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPL 512
Query: 622 GKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTE- 680
+FKK +F LT+ L++ K P I + NI A EK+EE SF ++ QVI+T+
Sbjct: 513 MSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDD 572
Query: 681 ----KPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLG 736
+ Y+Q E N+W+ L +VS N L YHP V+ W CC + + G
Sbjct: 573 AGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQG 632
Query: 737 CKPCTAGVPADIQID-IDEDRETERIY-SLFTLSLLKLQKMEEACGTI---AVYQGPQKE 791
C + V D +D D E + IY L + + ++ E G V P K
Sbjct: 633 CDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKV 692
Query: 792 PDD 794
P+D
Sbjct: 693 PED 695
Score = 45.8 bits (107), Expect = 2e-04
Identities = 44/152 (28%), Positives = 71/152 (46%), Gaps = 10/152 (6%)
Query: 40 LRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPR-T 98
LR + EA++L P + D F + + T +V+KS P ++E F FE+
Sbjct: 63 LRCSVLEARDLAPK-DRNGTSDPFVRVRY-KGRTRETSIVKKSCYPRWNETFEFELQEGA 120
Query: 99 FQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQ-----GKV 153
+ L +D +++ R+ +GKV I + L +E WF LQP S S G +
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
Query: 154 HLELKLNELITENGTVCQQLVVHIKACHGLPL 185
LE++L + + Q L VH+ CH + L
Sbjct: 181 QLEVRLRDETVLPSSYYQPL-VHL-LCHEVKL 210
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 122 bits (306), Expect = 1e-27
Identities = 94/380 (24%), Positives = 177/380 (46%), Gaps = 35/380 (9%)
Query: 173 LVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVK-KKTSNPQFNEIFYFEVTR 231
LV+HI+ H LP+ + +PY + L N + K ++ NP ++E F F+
Sbjct: 596 LVLHIEEAHKLPVKH--FTNPYCNIYL-----NSVQVAKTHAREGQNPVWSEEFVFDDL- 647
Query: 232 SSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLL 291
DI + EI + N +D + ++ ++ L+ + W+LL
Sbjct: 648 -------------PPDINRFEITLS--NKTKKSKDPDILFMRCQLSRLQKGHATDEWFLL 692
Query: 292 QPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILS 351
+ + K + GSLR+ Y+ + ++P E Y K L+L+ Y LS
Sbjct: 693 ----SSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQK------ELHVVYALS 742
Query: 352 EIC-RDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMM 410
+C +D+ L+R+ LH + + ++ +A T+FR +LA+ +++ M
Sbjct: 743 HVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYM 802
Query: 411 KIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKS 470
K ++ LK + +I +S +SCE+ P KL++ ++V N +L + +L I +
Sbjct: 803 KATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMA 862
Query: 471 SMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHP 530
S P + I+ L++ ++P + ++ VS FVFLR A+++P F++ P
Sbjct: 863 SEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSP 922
Query: 531 DAQTIRTLTLISKTIQTLGS 550
RTL L++K++Q L +
Sbjct: 923 SPIAARTLILVAKSVQNLAN 942
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 122 bits (306), Expect = 1e-27
Identities = 94/380 (24%), Positives = 177/380 (46%), Gaps = 35/380 (9%)
Query: 173 LVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVK-KKTSNPQFNEIFYFEVTR 231
LV+HI+ H LP+ + +PY + L N + K ++ NP ++E F F+
Sbjct: 419 LVLHIEEAHKLPVKH--FTNPYCNIYL-----NSVQVAKTHAREGQNPVWSEEFVFDDL- 470
Query: 232 SSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLL 291
DI + EI + N +D + ++ ++ L+ + W+LL
Sbjct: 471 -------------PPDINRFEITLS--NKTKKSKDPDILFMRCQLSRLQKGHATDEWFLL 515
Query: 292 QPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILS 351
+ + K + GSLR+ Y+ + ++P E Y K L+L+ Y LS
Sbjct: 516 ----SSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQK------ELHVVYALS 565
Query: 352 EIC-RDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMM 410
+C +D+ L+R+ LH + + ++ +A T+FR +LA+ +++ M
Sbjct: 566 HVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYM 625
Query: 411 KIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKS 470
K ++ LK + +I +S +SCE+ P KL++ ++V N +L + +L I +
Sbjct: 626 KATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMA 685
Query: 471 SMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHP 530
S P + I+ L++ ++P + ++ VS FVFLR A+++P F++ P
Sbjct: 686 SEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSP 745
Query: 531 DAQTIRTLTLISKTIQTLGS 550
RTL L++K++Q L +
Sbjct: 746 SPIAARTLILVAKSVQNLAN 765
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 118 bits (296), Expect = 2e-26
Identities = 98/338 (28%), Positives = 164/338 (48%), Gaps = 22/338 (6%)
Query: 268 FLGEIKVPVNVLRTDSSHQAWY-LLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYY 326
+LG + +P + + WY ++ P G K +R+ Y +LP E Y
Sbjct: 166 YLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGP----MIRIKARYQTITILPMEMY 221
Query: 327 GPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFAT--AVAEL 384
+ + A+ ILS + K + LV +L K+ F T ++E+
Sbjct: 222 KEFAEHITNH--YLGLCAALEPILS--AKTKEEMASALVHILQSTGKVKDFLTDLMMSEV 277
Query: 385 DLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK 444
D + + + IFR N+LAT+ ++E +K+VG YL+ L + + +S ++CE+DP K
Sbjct: 278 D-RCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCS 336
Query: 445 EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAV 504
D E+ + NL+ + F I+ S P + ++F S RQ + R P + +
Sbjct: 337 AADLPEH-QGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSR--GRPDISERLI 393
Query: 505 SSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKET 564
S+ +FLRF A++SP F+L +PD +T RTLTLI+K Q L ++ +K KE
Sbjct: 394 SASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANF-----AKFGSKEE 448
Query: 565 FMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSE 602
+M F F E + +++FL EIS+ ET ++ E
Sbjct: 449 YM-SFMNQFLEHEW-TNMQRFLLEISNPETLSNTAGFE 484
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 118 bits (296), Expect = 2e-26
Identities = 98/338 (28%), Positives = 164/338 (48%), Gaps = 22/338 (6%)
Query: 268 FLGEIKVPVNVLRTDSSHQAWY-LLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYY 326
+LG + +P + + WY ++ P G K +R+ Y +LP E Y
Sbjct: 262 YLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGP----MIRIKARYQTITILPMEMY 317
Query: 327 GPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFAT--AVAEL 384
+ + A+ ILS + K + LV +L K+ F T ++E+
Sbjct: 318 KEFAEHITNH--YLGLCAALEPILS--AKTKEEMASALVHILQSTGKVKDFLTDLMMSEV 373
Query: 385 DLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK 444
D + + + IFR N+LAT+ ++E +K+VG YL+ L + + +S ++CE+DP K
Sbjct: 374 D-RCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCS 432
Query: 445 EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAV 504
D E+ + NL+ + F I+ S P + ++F S RQ + R P + +
Sbjct: 433 AADLPEH-QGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSR--GRPDISERLI 489
Query: 505 SSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKET 564
S+ +FLRF A++SP F+L +PD +T RTLTLI+K Q L ++ +K KE
Sbjct: 490 SASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANF-----AKFGSKEE 544
Query: 565 FMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSE 602
+M F F E + +++FL EIS+ ET ++ E
Sbjct: 545 YM-SFMNQFLEHEW-TNMQRFLLEISNPETLSNTAGFE 580
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 113 bits (282), Expect = 8e-25
Identities = 91/330 (27%), Positives = 161/330 (48%), Gaps = 22/330 (6%)
Query: 268 FLGEIKVPVNVLRTDSSHQAWYLLQ-PRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYY 326
++G + +P + + WY + P N K+ S+R+ + +LP E Y
Sbjct: 394 YVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQY 449
Query: 327 GPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFAT--AVAEL 384
+ + + + + ++S R+K + LV +L + F T ++E+
Sbjct: 450 KEFAEFVTSNYTM--LCSVLEPVIS--VRNKEELACALVHILQSTGRAKDFLTDLVMSEV 505
Query: 385 DLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK 444
D D IFR N++AT+ ++E +K+VG YL L + + +S ++CE+DP K
Sbjct: 506 DRCGEHDV-LIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCS 564
Query: 445 EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAV 504
+ +++ + NL+ + F I+ S P + ++F S +Q R D + +
Sbjct: 565 SSELIDH-QSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQD--ISERLI 621
Query: 505 SSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKET 564
S+ +FLRF A++SP F+L +PD +T RTLTLI+K IQ L ++ +K KE
Sbjct: 622 SASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANF-----AKFGNKEE 676
Query: 565 FMCEFFKMFQEEGYIIAVKKFLDEISSTET 594
+M F F E + +K+FL EIS+ +T
Sbjct: 677 YMA-FMNDFLEHEW-GGMKRFLLEISNPDT 704
Score = 30.0 bits (66), Expect = 9.4
Identities = 29/123 (23%), Positives = 47/123 (38%), Gaps = 10/123 (8%)
Query: 40 LRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTF 99
LR I EAK+L P + FC + LD RT K+ + F+ E F F
Sbjct: 319 LRLWIIEAKDLAP------KKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPL 372
Query: 100 QYLSFYVY----DKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHL 155
++ ++Y K ++ +G V I + E W+ + N G +
Sbjct: 373 HSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSI 432
Query: 156 ELK 158
+K
Sbjct: 433 RIK 435
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 113 bits (282), Expect = 8e-25
Identities = 91/330 (27%), Positives = 161/330 (48%), Gaps = 22/330 (6%)
Query: 268 FLGEIKVPVNVLRTDSSHQAWYLLQ-PRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYY 326
++G + +P + + WY + P N K+ S+R+ + +LP E Y
Sbjct: 246 YVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQY 301
Query: 327 GPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFAT--AVAEL 384
+ + + + + ++S R+K + LV +L + F T ++E+
Sbjct: 302 KEFAEFVTSNYTM--LCSVLEPVIS--VRNKEELACALVHILQSTGRAKDFLTDLVMSEV 357
Query: 385 DLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK 444
D D IFR N++AT+ ++E +K+VG YL L + + +S ++CE+DP K
Sbjct: 358 DRCGEHDV-LIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCS 416
Query: 445 EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAV 504
+ +++ + NL+ + F I+ S P + ++F S +Q R D + +
Sbjct: 417 SSELIDH-QSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQD--ISERLI 473
Query: 505 SSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKET 564
S+ +FLRF A++SP F+L +PD +T RTLTLI+K IQ L ++ +K KE
Sbjct: 474 SASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANF-----AKFGNKEE 528
Query: 565 FMCEFFKMFQEEGYIIAVKKFLDEISSTET 594
+M F F E + +K+FL EIS+ +T
Sbjct: 529 YMA-FMNDFLEHEW-GGMKRFLLEISNPDT 556
Score = 30.0 bits (66), Expect = 9.4
Identities = 29/123 (23%), Positives = 47/123 (38%), Gaps = 10/123 (8%)
Query: 40 LRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTF 99
LR I EAK+L P + FC + LD RT K+ + F+ E F F
Sbjct: 171 LRLWIIEAKDLAP------KKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPL 224
Query: 100 QYLSFYVY----DKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHL 155
++ ++Y K ++ +G V I + E W+ + N G +
Sbjct: 225 HSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSI 284
Query: 156 ELK 158
+K
Sbjct: 285 RIK 287
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo
sapiens]
Length = 1343
Score = 112 bits (281), Expect = 1e-24
Identities = 101/354 (28%), Positives = 167/354 (47%), Gaps = 34/354 (9%)
Query: 268 FLGEIKVPVNVLRTDSSHQAWY-LLQPRDNGNKSSKTDDLG----------------SLR 310
++G + VPV L + WY + P +G G ++R
Sbjct: 342 YVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVR 401
Query: 311 LNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLH 370
L Y +LP E Y + + + A L+ + K + LV +L
Sbjct: 402 LKARYQTMSILPMELYKEFAEYVTNH--YRMLCAVLEPALN--VKGKEEVASALVHILQS 457
Query: 371 HDKLVPFAT--AVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDE 428
K F + A++E+D + + + IFR N+LAT+ ++E M+++G YLK + +
Sbjct: 458 TGKAKDFLSDMAMSEVD-RFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRA 516
Query: 429 ICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQM 488
+ +S ++CE+DPIK E+ + NLR + +V S P + ++F S R
Sbjct: 517 LYESEENCEVDPIKCTASSLAEH-QANLRMCCELALCKVVNSHCVFPRELKEVFASWRLR 575
Query: 489 ATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTL 548
+R D + +S+ +FLRF A++SP F L +PD QT RTLTLI+K IQ L
Sbjct: 576 CAERGRED--IADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNL 633
Query: 549 GSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSE 602
++ + SK F FM EF ++ E G ++++FL EIS+ +T +S + E
Sbjct: 634 ANFSKFT-SKEDFL-GFMNEFLEL--EWG---SMQQFLYEISNLDTLTNSSSFE 680
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 100 bits (250), Expect = 4e-21
Identities = 68/219 (31%), Positives = 112/219 (51%), Gaps = 16/219 (7%)
Query: 383 ELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSK----SCEI 438
E++L D+ T+FRGNSLA++ + K+ G YL+ L P+L + SS S E+
Sbjct: 1264 EVELADSMQ--TLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEV 1321
Query: 439 DPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH 498
DP +L+ +++E N+ NL +K F+ I+ SS P + + + L Q+ +QRFP +
Sbjct: 1322 DPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQN-- 1379
Query: 499 VQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSK 558
AV S +FLRF A+VSP+ + P + R L L+SK +Q++ + +K +
Sbjct: 1380 -SIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEE 1438
Query: 559 SSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKES 597
F F + + A + FLD S T ++
Sbjct: 1439 H-------MRPFNDFVKSNFDAARRFFLDIASDCPTSDA 1470
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 97.4 bits (241), Expect = 5e-20
Identities = 65/199 (32%), Positives = 107/199 (53%), Gaps = 10/199 (5%)
Query: 395 IFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENNKE 454
+FR N+LAT+ +DE MK+V YL+ TL ++ +C S++ CE+DP K + + ++
Sbjct: 498 LFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASE-LPEHQA 556
Query: 455 NLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFA 514
LR +++F TI+ S P + +F S R+ +R + V + +FLR
Sbjct: 557 RLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLFLRLLC 614
Query: 515 VAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQ 574
A+++P F L P HP RTLTLI+K IQ L +++ KE +M F F
Sbjct: 615 PAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLA-----NRAPFGEKEAYM-GFMNSFL 668
Query: 575 EEGYIIAVKKFLDEISSTE 593
EE + A++ FLD+++ +
Sbjct: 669 EE-HGPAMQCFLDQVAMVD 686
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 88.6 bits (218), Expect = 2e-17
Identities = 68/240 (28%), Positives = 112/240 (46%), Gaps = 37/240 (15%)
Query: 383 ELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSK----SCEI 438
E++L D+ T+FRGNSLA++ + K+ G YL+ L P+L + SS S E+
Sbjct: 1264 EVELADSMQ--TLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEV 1321
Query: 439 DPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQ----------- 487
DP +L+ +++E N+ NL +K F+ I+ SS P + + + L Q
Sbjct: 1322 DPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKAT 1381
Query: 488 ----------MATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRT 537
+ +QRFP + AV S +FLRF A+VSP+ + P + R
Sbjct: 1382 VKEKKENKKSVVSQRFPQN---SIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERG 1438
Query: 538 LTLISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKES 597
L L+SK +Q++ + +K + F F + + A + FLD S T ++
Sbjct: 1439 LKLMSKILQSIANHVLFTKEEH-------MRPFNDFVKSNFDAARRFFLDIASDCPTSDA 1491
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 72.8 bits (177), Expect = 1e-12
Identities = 40/133 (30%), Positives = 73/133 (54%), Gaps = 6/133 (4%)
Query: 611 MYKRAQGRTRIGKKNFKKRWFCLTSRELTYH---KQPGKDAIYTIPVKNILAVEKL---E 664
+ KR+Q + ++ N+K+R F LT L+Y+ K +I +K I VEK+ E
Sbjct: 11 LLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEE 70
Query: 665 ESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNW 724
++ ++ FQ+++ + LYV A+N ++W+ L + R N + L YH +++G +
Sbjct: 71 QTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKF 130
Query: 725 LCCQETGENTLGC 737
LCCQ++ + GC
Sbjct: 131 LCCQQSCKAAPGC 143
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 72.8 bits (177), Expect = 1e-12
Identities = 40/133 (30%), Positives = 73/133 (54%), Gaps = 6/133 (4%)
Query: 611 MYKRAQGRTRIGKKNFKKRWFCLTSRELTYH---KQPGKDAIYTIPVKNILAVEKL---E 664
+ KR+Q + ++ N+K+R F LT L+Y+ K +I +K I VEK+ E
Sbjct: 11 LLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEE 70
Query: 665 ESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNW 724
++ ++ FQ+++ + LYV A+N ++W+ L + R N + L YH +++G +
Sbjct: 71 QTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKF 130
Query: 725 LCCQETGENTLGC 737
LCCQ++ + GC
Sbjct: 131 LCCQQSCKAAPGC 143
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 68.9 bits (167), Expect = 2e-11
Identities = 66/233 (28%), Positives = 105/233 (45%), Gaps = 29/233 (12%)
Query: 69 DQEEVYRTQVVEKSLSPFFSEEFYFEIPRTF---QYLSFYVYDKNVLQRDLRIGKVAIKK 125
D+++ Y T+V K+L+P F+E F F++P + L +YD + + IG+V +
Sbjct: 186 DKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPM 245
Query: 126 EDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTV--CQQLVVHIKACHGL 183
+ E W LQ G+ KL ++ T V +L V I L
Sbjct: 246 NTVDLGQPIEEWRDLQG--------GEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNL 297
Query: 184 PLIN-GQSCDPYATVSLV-GPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQF 241
++ G DPY + L+ R +KKT VKKKT NP FNE F FE
Sbjct: 298 KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFE------------- 344
Query: 242 QVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPR 294
+ E I+K+++ + + + L ++ +G+I V N T+ H + L PR
Sbjct: 345 -IPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPR 396
Score = 51.2 bits (121), Expect = 4e-06
Identities = 38/145 (26%), Positives = 68/145 (46%), Gaps = 20/145 (13%)
Query: 172 QLVVHIKACHGLPLIN-GQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVT 230
QL V + LP ++ G + DPY V L+ P + + +TKV +KT NP FNE F
Sbjct: 155 QLTVGVLQAAELPALDMGGTSDPYVKVFLL-PDKKKKYETKVHRKTLNPAFNETF----- 208
Query: 231 RSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYL 290
F+V +++ + + +++ + +GE+KVP+N + + W
Sbjct: 209 ---------TFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRD 259
Query: 291 LQPRDNGNKSSKTDDLGSLRLNICY 315
LQ G + + + LG + ++ Y
Sbjct: 260 LQ----GGEKEEPEKLGDICTSLRY 280
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 68.9 bits (167), Expect = 2e-11
Identities = 66/233 (28%), Positives = 105/233 (45%), Gaps = 29/233 (12%)
Query: 69 DQEEVYRTQVVEKSLSPFFSEEFYFEIPRTF---QYLSFYVYDKNVLQRDLRIGKVAIKK 125
D+++ Y T+V K+L+P F+E F F++P + L +YD + + IG+V +
Sbjct: 186 DKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPM 245
Query: 126 EDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTV--CQQLVVHIKACHGL 183
+ E W LQ G+ KL ++ T V +L V I L
Sbjct: 246 NTVDLGQPIEEWRDLQG--------GEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNL 297
Query: 184 PLIN-GQSCDPYATVSLV-GPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQF 241
++ G DPY + L+ R +KKT VKKKT NP FNE F FE
Sbjct: 298 KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFE------------- 344
Query: 242 QVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPR 294
+ E I+K+++ + + + L ++ +G+I V N T+ H + L PR
Sbjct: 345 -IPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPR 396
Score = 51.2 bits (121), Expect = 4e-06
Identities = 38/145 (26%), Positives = 68/145 (46%), Gaps = 20/145 (13%)
Query: 172 QLVVHIKACHGLPLIN-GQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVT 230
QL V + LP ++ G + DPY V L+ P + + +TKV +KT NP FNE F
Sbjct: 155 QLTVGVLQAAELPALDMGGTSDPYVKVFLL-PDKKKKYETKVHRKTLNPAFNETF----- 208
Query: 231 RSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYL 290
F+V +++ + + +++ + +GE+KVP+N + + W
Sbjct: 209 ---------TFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRD 259
Query: 291 LQPRDNGNKSSKTDDLGSLRLNICY 315
LQ G + + + LG + ++ Y
Sbjct: 260 LQ----GGEKEEPEKLGDICTSLRY 280
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 68.6 bits (166), Expect = 2e-11
Identities = 49/160 (30%), Positives = 76/160 (47%), Gaps = 29/160 (18%)
Query: 608 EGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHK---QPGKDAIY--TIPVKNILAVEK 662
E KR+Q + + NFKKR F LT +L+Y++ + G+ +I V+ I VE
Sbjct: 7 ESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVET 66
Query: 663 L----------------EESSFNKKNM--------FQVIHTEKPLYVQANNCVEANEWID 698
+ EESS ++ FQV++ E PLYV + WI
Sbjct: 67 VVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIH 126
Query: 699 VLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLGCK 738
L V R N + + YHP +++G +LCC +T +N +GC+
Sbjct: 127 QLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQ 166
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 67.8 bits (164), Expect = 4e-11
Identities = 41/138 (29%), Positives = 65/138 (47%), Gaps = 6/138 (4%)
Query: 606 LKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYH------KQPGKDAIYTIPVKNILA 659
L E ++ K++Q + R NFK R+F LT L Y K+ K +I +K +
Sbjct: 6 LLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEI 65
Query: 660 VEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVY 719
V+ + K FQV+H LYV A + W+ L +R N + + YHP+ +
Sbjct: 66 VKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFW 125
Query: 720 LNGNWLCCQETGENTLGC 737
++G W CC + + GC
Sbjct: 126 MDGKWRCCSQLEKLATGC 143
>gi|14249614 synaptotagmin-like 1 [Homo sapiens]
Length = 550
Score = 67.0 bits (162), Expect = 7e-11
Identities = 61/222 (27%), Positives = 101/222 (45%), Gaps = 38/222 (17%)
Query: 148 EVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQ 207
+V+G VH L E G +L VH+ C GL + DPY L+ P + +
Sbjct: 253 QVRGSVHFALHY-----EPGAA--ELRVHVIQCQGLAAARRRRSDPYVKSYLL-PDKQSK 304
Query: 208 KKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDV 267
+KT VKK+ NP FNE ++ V + +++ + + +W+ +L +++
Sbjct: 305 RKTAVKKRNLNPVFNETL--------------RYSVPQAELQGRVLSLSVWHRESLGRNI 350
Query: 268 FLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDL---GSLRLNICY----TEDYV 320
FLGE++VP++ S W LQPR DDL G L L++ Y +E
Sbjct: 351 FLGEVEVPLDTWDW-GSEPTWLPLQPR----VPPSPDDLPSRGLLALSLKYVPAGSEGAG 405
Query: 321 LPSEYYGPLKTLLLKSPDVQPISASA--AYILSEICRDKNDA 360
LP G L + ++ D+ P+ A + Y+ + D + A
Sbjct: 406 LPPS--GELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQA 445
Score = 44.7 bits (104), Expect = 4e-04
Identities = 39/170 (22%), Positives = 79/170 (46%), Gaps = 11/170 (6%)
Query: 69 DQEEVYRTQVVEKSLSPFFSEEFYFEIPRT---FQYLSFYVYDKNVLQRDLRIGKVAIKK 125
D++ +T V +++L+P F+E + +P+ + LS V+ + L R++ +G+V +
Sbjct: 300 DKQSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPL 359
Query: 126 EDLCNHSGKETWFSLQ----PVDSNSEVQGKVHLELKLNELITENGTVCQQLVVH--IKA 179
D + + TW LQ P + +G + L LK +E + +H +K
Sbjct: 360 -DTWDWGSEPTWLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKE 418
Query: 180 CHGLPLINGQSCDPYA-TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFE 228
L + S D Y L S+ +++T+V +++ +P FN ++
Sbjct: 419 ARDLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYD 468
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 63.2 bits (152), Expect = 1e-09
Identities = 57/231 (24%), Positives = 105/231 (45%), Gaps = 25/231 (10%)
Query: 69 DQEEVYRTQVVEKSLSPFFSEEFYFEIPRTF---QYLSFYVYDKNVLQRDLRIGKVAIKK 125
D+++ + T+V K+L+P F+E+F F++P + + L VYD + + IG+ +
Sbjct: 189 DKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPM 248
Query: 126 EDLCNHSGKETWFSLQPVDSNSEVQ-GKVHLELKLNELITENGTVCQQLVVHIKACHGLP 184
+ E W LQ + + + G + L+ T + VV ++A +
Sbjct: 249 NTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVP------TAGKLTVVILEAKNLKK 302
Query: 185 LINGQSCDPYATVSLV-GPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQV 243
+ G DPY + L+ R +KKT +KK T NP +NE F FE V
Sbjct: 303 MDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE--------------V 348
Query: 244 EEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPR 294
E I+K+++ + + + + ++ +G++ V N + H + L PR
Sbjct: 349 PFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPR 399
Score = 48.1 bits (113), Expect = 3e-05
Identities = 42/140 (30%), Positives = 61/140 (43%), Gaps = 16/140 (11%)
Query: 172 QLVVHIKACHGLPLIN-GQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVT 230
QL+V I LP ++ G + DPY V L+ P + + +TKV +KT NP FNE F F+V
Sbjct: 158 QLLVGIIQAAELPALDMGGTSDPYVKVFLL-PDKKKKFETKVHRKTLNPVFNEQFTFKVP 216
Query: 231 RSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYL 290
S + V + D + +GE KVP+N + + W
Sbjct: 217 YSELGGKTLVMAVYDFD--------------RFSKHDIIGEFKVPMNTVDFGHVTEEWRD 262
Query: 291 LQPRDNGNKSSKTDDLGSLR 310
LQ + + D SLR
Sbjct: 263 LQSAEKEEQEKLGDICFSLR 282
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 63.2 bits (152), Expect = 1e-09
Identities = 57/231 (24%), Positives = 105/231 (45%), Gaps = 25/231 (10%)
Query: 69 DQEEVYRTQVVEKSLSPFFSEEFYFEIPRTF---QYLSFYVYDKNVLQRDLRIGKVAIKK 125
D+++ + T+V K+L+P F+E+F F++P + + L VYD + + IG+ +
Sbjct: 189 DKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPM 248
Query: 126 EDLCNHSGKETWFSLQPVDSNSEVQ-GKVHLELKLNELITENGTVCQQLVVHIKACHGLP 184
+ E W LQ + + + G + L+ T + VV ++A +
Sbjct: 249 NTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVP------TAGKLTVVILEAKNLKK 302
Query: 185 LINGQSCDPYATVSLV-GPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQV 243
+ G DPY + L+ R +KKT +KK T NP +NE F FE V
Sbjct: 303 MDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE--------------V 348
Query: 244 EEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPR 294
E I+K+++ + + + + ++ +G++ V N + H + L PR
Sbjct: 349 PFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPR 399
Score = 48.1 bits (113), Expect = 3e-05
Identities = 42/140 (30%), Positives = 61/140 (43%), Gaps = 16/140 (11%)
Query: 172 QLVVHIKACHGLPLIN-GQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVT 230
QL+V I LP ++ G + DPY V L+ P + + +TKV +KT NP FNE F F+V
Sbjct: 158 QLLVGIIQAAELPALDMGGTSDPYVKVFLL-PDKKKKFETKVHRKTLNPVFNEQFTFKVP 216
Query: 231 RSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYL 290
S + V + D + +GE KVP+N + + W
Sbjct: 217 YSELGGKTLVMAVYDFD--------------RFSKHDIIGEFKVPMNTVDFGHVTEEWRD 262
Query: 291 LQPRDNGNKSSKTDDLGSLR 310
LQ + + D SLR
Sbjct: 263 LQSAEKEEQEKLGDICFSLR 282
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 63.2 bits (152), Expect = 1e-09
Identities = 57/231 (24%), Positives = 105/231 (45%), Gaps = 25/231 (10%)
Query: 69 DQEEVYRTQVVEKSLSPFFSEEFYFEIPRTF---QYLSFYVYDKNVLQRDLRIGKVAIKK 125
D+++ + T+V K+L+P F+E+F F++P + + L VYD + + IG+ +
Sbjct: 189 DKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPM 248
Query: 126 EDLCNHSGKETWFSLQPVDSNSEVQ-GKVHLELKLNELITENGTVCQQLVVHIKACHGLP 184
+ E W LQ + + + G + L+ T + VV ++A +
Sbjct: 249 NTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVP------TAGKLTVVILEAKNLKK 302
Query: 185 LINGQSCDPYATVSLV-GPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQV 243
+ G DPY + L+ R +KKT +KK T NP +NE F FE V
Sbjct: 303 MDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE--------------V 348
Query: 244 EEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPR 294
E I+K+++ + + + + ++ +G++ V N + H + L PR
Sbjct: 349 PFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPR 399
Score = 48.1 bits (113), Expect = 3e-05
Identities = 42/140 (30%), Positives = 61/140 (43%), Gaps = 16/140 (11%)
Query: 172 QLVVHIKACHGLPLIN-GQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVT 230
QL+V I LP ++ G + DPY V L+ P + + +TKV +KT NP FNE F F+V
Sbjct: 158 QLLVGIIQAAELPALDMGGTSDPYVKVFLL-PDKKKKFETKVHRKTLNPVFNEQFTFKVP 216
Query: 231 RSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYL 290
S + V + D + +GE KVP+N + + W
Sbjct: 217 YSELGGKTLVMAVYDFD--------------RFSKHDIIGEFKVPMNTVDFGHVTEEWRD 262
Query: 291 LQPRDNGNKSSKTDDLGSLR 310
LQ + + D SLR
Sbjct: 263 LQSAEKEEQEKLGDICFSLR 282
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 62.4 bits (150), Expect = 2e-09
Identities = 58/231 (25%), Positives = 98/231 (42%), Gaps = 25/231 (10%)
Query: 69 DQEEVYRTQVVEKSLSPFFSEEFYFEIPRTF---QYLSFYVYDKNVLQRDLRIGKVAIKK 125
D+ Y T+V ++L+P F E F F++P + L VYD + R+ IG+V +
Sbjct: 155 DKRRRYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPM 214
Query: 126 EDLCNHSGKETWFSLQPVD-SNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLP 184
+ + W LQ E G + L+ T + V+ ++A +
Sbjct: 215 SSVDLGRPVQAWRELQAAPREEQEKLGDICFSLRYVP------TAGKLTVIVLEAKNLKK 268
Query: 185 LINGQSCDPYATVSLV-GPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQV 243
+ G DPY V L+ G + +KKT +KK T NP +NE F FEV
Sbjct: 269 MDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPC------------ 316
Query: 244 EEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPR 294
+ ++K+++ + + + L ++ +G + V H A L PR
Sbjct: 317 --DQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPR 365
Score = 47.4 bits (111), Expect = 6e-05
Identities = 49/172 (28%), Positives = 80/172 (46%), Gaps = 31/172 (18%)
Query: 172 QLVVHIKACHGLPLIN-GQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVT 230
QL+V I GL ++ G S DPY V L+ P + + +TKV ++T NP F E F F+V
Sbjct: 124 QLLVGILQAMGLAALDLGGSSDPYVRVYLL-PDKRRRYETKVHRQTLNPHFGETFAFKVP 182
Query: 231 RSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYL 290
R V + D ++ +GE++VP++ + QAW
Sbjct: 183 YVELGGRVLVMAVYDFD--------------RFSRNDAIGEVRVPMSSVDLGRPVQAWRE 228
Query: 291 LQ--PRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQ 340
LQ PR+ K LG +IC++ YV + G L ++L++ +++
Sbjct: 229 LQAAPREEQEK------LG----DICFSLRYVPTA---GKLTVIVLEAKNLK 267
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,349,324
Number of Sequences: 37866
Number of extensions: 1398952
Number of successful extensions: 5839
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 95
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 5329
Number of HSP's gapped (non-prelim): 403
length of query: 849
length of database: 18,247,518
effective HSP length: 111
effective length of query: 738
effective length of database: 14,044,392
effective search space: 10364761296
effective search space used: 10364761296
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.