Guide to the Human Genome
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Search of human proteins with 38045919

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38045919 huntingtin interacting protein 1 [Homo sapiens]
         (1037 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38045919 huntingtin interacting protein 1 [Homo sapiens]          2019   0.0  
gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]   984   0.0  
gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]    842   0.0  
gi|156938343 talin 2 [Homo sapiens]                                   130   6e-30
gi|223029410 talin 1 [Homo sapiens]                                   127   5e-29
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    77   6e-14
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    77   6e-14
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    77   6e-14
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    77   6e-14
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           75   3e-13
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           75   3e-13
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           75   3e-13
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                75   3e-13
gi|42794779 myosin 18A isoform b [Homo sapiens]                        75   3e-13
gi|28416946 myosin 18A isoform a [Homo sapiens]                        75   3e-13
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]    75   3e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    74   7e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     74   9e-13
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    73   2e-12
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    72   2e-12
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    72   3e-12
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         71   5e-12
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    71   5e-12
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    71   5e-12
gi|31982906 cingulin-like 1 [Homo sapiens]                             71   6e-12
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    70   8e-12
gi|16262452 cingulin [Homo sapiens]                                    70   1e-11
gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens]         69   2e-11
gi|4504063 golgin 97 [Homo sapiens]                                    69   2e-11
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    69   3e-11

>gi|38045919 huntingtin interacting protein 1 [Homo sapiens]
          Length = 1037

 Score = 2019 bits (5231), Expect = 0.0
 Identities = 1037/1037 (100%), Positives = 1037/1037 (100%)

Query: 1    MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHA 60
            MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHA
Sbjct: 1    MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHA 60

Query: 61   RTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNE 120
            RTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNE
Sbjct: 61   RTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNE 120

Query: 121  LSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN 180
            LSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN
Sbjct: 121  LSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN 180

Query: 181  FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTV 240
            FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTV
Sbjct: 181  FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTV 240

Query: 241  KLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLR 300
            KLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLR
Sbjct: 241  KLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLR 300

Query: 301  ASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF 360
            ASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF
Sbjct: 301  ASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF 360

Query: 361  NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQ 420
            NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQ
Sbjct: 361  NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQ 420

Query: 421  HLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480
            HLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ
Sbjct: 421  HLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480

Query: 481  NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ 540
            NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ
Sbjct: 481  NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ 540

Query: 541  ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD 600
            ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD
Sbjct: 541  ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD 600

Query: 601  TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLST 660
            TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLST
Sbjct: 601  TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLST 660

Query: 661  VTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS 720
            VTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS
Sbjct: 661  VTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS 720

Query: 721  LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG 780
            LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG
Sbjct: 721  LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG 780

Query: 781  DLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA 840
            DLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA
Sbjct: 781  DLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA 840

Query: 841  SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF 900
            SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF
Sbjct: 841  SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF 900

Query: 901  EELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQI 960
            EELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQI
Sbjct: 901  EELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQI 960

Query: 961  EETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE 1020
            EETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE
Sbjct: 961  EETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE 1020

Query: 1021 GTEASPPTLQEVVTEKE 1037
            GTEASPPTLQEVVTEKE
Sbjct: 1021 GTEASPPTLQEVVTEKE 1037


>gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]
          Length = 1068

 Score =  984 bits (2545), Expect = 0.0
 Identities = 529/1055 (50%), Positives = 719/1055 (68%), Gaps = 43/1055 (4%)

Query: 8    MKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGT 67
            M  + N   +VLSRR  G  LEA ERE F++TQ +SI+KAINTQE  VKEKHAR  ILGT
Sbjct: 1    MNSIKNVPARVLSRRP-GHSLEA-EREQFDKTQAISISKAINTQEAPVKEKHARRIILGT 58

Query: 68   HHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRM 127
            HHEKGA TFWS    LPL S+++L WKFCHV HK+LRDGHPNVL D  RYR+ + ++  +
Sbjct: 59   HHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDL 118

Query: 128  WGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVE 187
            WGHL + YGQL ++Y KLL TK+ +H K+P+FP  L+++D  L++A  +DVNN FQLTVE
Sbjct: 119  WGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVE 178

Query: 188  MFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLH 247
            MFDY++CEL L ++VF  L+ + +VS  ++GQCRLAPLIQVI DCSHLY YTVKLLFKLH
Sbjct: 179  MFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLH 238

Query: 248  SCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEH 307
            SCLPADTLQGHRDRF EQF  L++ F R+S++ YFKRLIQIP+LPE PPNFLRASAL+EH
Sbjct: 239  SCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEH 298

Query: 308  ISPVVVIPAEASSPDSEPVLEKDDLMDMD----ASQQNLFDNKFDDIFGSSFSSDPFNFN 363
            I PVVVIP EA  P+ E   E ++L+++     A +  +  + FD  FG           
Sbjct: 299  IKPVVVIPEEA--PEDE---EPENLIEISTGPPAGEPVVVADLFDQTFGPP--------- 344

Query: 364  SQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLR 423
              NG  KD++D  IE L RE+  L+++LE +K E+QR + QLK  V+ LE +L EQ+  +
Sbjct: 345  --NGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQK 402

Query: 424  QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
            Q+A  D E LR EL +LR  + + E++Q    E ERKA A E RY+KLKEK+SELV  HA
Sbjct: 403  QKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 462

Query: 484  DLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELA 543
            +LLRKNA+  KQ+++ +Q+Q ++ R K++L   +E++  + + K +E+ + LE LK+EL 
Sbjct: 463  ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE 522

Query: 544  TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603
                EL   Q +L  + QS++  ++    L  E+D+L      RE +L A +  +++T+ 
Sbjct: 523  AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582

Query: 604  KLA---------------------STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQL 642
             L+                     S E+ + Q   D++  +L G+   A  ++QDA+++L
Sbjct: 583  ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKL 642

Query: 643  EEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDA 702
            ++P  + C  S D+L+S        +  LE+  +QYL    D S L+ ++T  +HL +D 
Sbjct: 643  DDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADT 702

Query: 703  IAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKA 762
            I +G  T   AP +PAD L + C++ G   L  +  L+++ +L +  ++ +R  L  I  
Sbjct: 703  IINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQ 762

Query: 763  IGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNER 822
            +G+EL P+ LD++QEELG +VDKEMAATSAAIE A  RIE+M++++R   +GVKLEVNER
Sbjct: 763  LGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER 822

Query: 823  ILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWG 882
            IL  CT LM+AI++L+  S  LQ+EIVESGRG A+ +EFYAKNSRWTEGLISASKAVGWG
Sbjct: 823  ILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWG 882

Query: 883  ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGV 942
            AT +V+AAD VV   GK+EEL+VCSHEIAASTAQLVAASKVKA+K SP+L++LQ+ SR V
Sbjct: 883  ATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTV 942

Query: 943  NQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLG 1002
            N+  A VVAST SG+ QIE+ D MDFS ++L ++K+QEM++QVRVLELE  L+ ER +LG
Sbjct: 943  NERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLG 1002

Query: 1003 ELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037
            ELRK+HY LAG +    E     P T    VT K+
Sbjct: 1003 ELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1037


>gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]
          Length = 1048

 Score =  842 bits (2176), Expect = 0.0
 Identities = 477/1035 (46%), Positives = 660/1035 (63%), Gaps = 68/1035 (6%)

Query: 40   QTVSINKAINTQEVAVKEKHARTCILGTH----HEKGAQTFW-----SVVNRLPLSSNAV 90
            + V+  + + +   A +E     CIL TH       G    W     S V  +P    A 
Sbjct: 14   EPVAGRRFLGSPRPAAEESGLEVCILSTHTVRPESPGGPAIWMHCKTSGVRDVPGGQRA- 72

Query: 91   LCW---KFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLR 147
            L W   + C V   L RD       D               GHL + YGQL ++Y KLL 
Sbjct: 73   LAWFSLEHCGVLVCLGRDIGAGQALDR--------------GHLHDRYGQLVNVYTKLLL 118

Query: 148  TKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLD 207
            TK+ +H K+P+FP  L+++D  L++A  +DVNN FQLTVEMFDY++CEL L ++VF  L+
Sbjct: 119  TKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLN 178

Query: 208  MSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFT 267
             + +VS  ++GQCRLAPLIQVI DCSHLY YTVKLLFKLHSCLPADTLQGHRDRF EQF 
Sbjct: 179  TAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFH 238

Query: 268  KLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVL 327
             L++ F R+S++ YFKRLIQIP+LPE PPNFLRASAL+EHI PVVVIP EA  P+ E   
Sbjct: 239  SLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEA--PEDE--- 293

Query: 328  EKDDLMDMD----ASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYRE 383
            E ++L+++     A +  +  + FD  FG             NG  KD++D  IE L RE
Sbjct: 294  EPENLIEISTGPPAGEPVVVADLFDQTFGPP-----------NGSVKDDRDLQIESLKRE 342

Query: 384  ISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQ 443
            +  L+++LE +K E+QR + QLK  V+ LE +L EQ+  +Q+A  D E LR EL +LR  
Sbjct: 343  VEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAA 402

Query: 444  REDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ 503
            + + E++Q    E ERKA A E RY+KLKEK+SELV  HA+LLRKNA+  KQ+++ +Q+Q
Sbjct: 403  QLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQ 462

Query: 504  VDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSE 563
             ++ R K++L   +E++  + + K +E+ + LE LK+EL     EL   Q +L  + QS+
Sbjct: 463  EEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSK 522

Query: 564  ANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLA----------------- 606
            +  ++    L  E+D+L      RE +L A +  +++T+  L+                 
Sbjct: 523  SELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 582

Query: 607  ----STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVT 662
                S E+ + Q   D++  +L G+   A  ++QDA+++L++P  + C  S D+L+S   
Sbjct: 583  AERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQ 642

Query: 663  SISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLT 722
                 +  LE+  +QYL    D S L+ ++T  +HL +D I +G  T   AP +PAD L 
Sbjct: 643  EALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI 702

Query: 723  EACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL 782
            + C++ G   L  +  L+++ +L +  ++ +R  L  I  +G+EL P+ LD++QEELG +
Sbjct: 703  DTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAV 762

Query: 783  VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK 842
            VDKEMAATSAAIE A  RIE+M++++R   +GVKLEVNERIL  CT LM+AI++L+  S 
Sbjct: 763  VDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTST 822

Query: 843  DLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEE 902
             LQ+EIVESGRG A+ +EFYAKNSRWTEGLISASKAVGWGAT +V+AAD VV   GK+EE
Sbjct: 823  SLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEE 882

Query: 903  LMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
            L+VCSHEIAASTAQLVAASKVKA+K SP+L++LQ+ SR VN+  A VVAST SG+ QIE+
Sbjct: 883  LIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIED 942

Query: 963  TDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022
             D MDFS ++L ++K+QEM++QVRVLELE  L+ ER +LGELRK+HY LAG +    E  
Sbjct: 943  RDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEV 1002

Query: 1023 EASPPTLQEVVTEKE 1037
               P T    VT K+
Sbjct: 1003 AIRPSTAPRSVTTKK 1017


>gi|156938343 talin 2 [Homo sapiens]
          Length = 2542

 Score =  130 bits (327), Expect = 6e-30
 Identities = 124/534 (23%), Positives = 239/534 (44%), Gaps = 71/534 (13%)

Query: 557  ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEE-SMCQL 615
            ET A    N       L ++   LVSGAA   ++L+   +    T  +LA   +     L
Sbjct: 2011 ETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASL 2070

Query: 616  AKD--QRKMLLVGSRKAAEQVIQDALNQ--------LEEPPLISCAGSADHLLSTVTSIS 665
              D  + +++L+ + K   + + D ++         +++P +    G+A  +++ VTS+ 
Sbjct: 2071 GSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLL 2130

Query: 666  SCIEQLE--------------------------KSWSQYLACPEDISGLLHSITLL---- 695
              ++ +E                          K   +  + PE+   +   IT+     
Sbjct: 2131 KTVKAVEDEATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKA 2190

Query: 696  ---------------AHLTSDAIAHGATTCLRAP--PEPADSLTEACKQYGRE-TLAYLA 737
                           A+L+  A++   T C +A   P+ +D +     ++G E TL YL 
Sbjct: 2191 VAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPDVSDEVRTRALRFGTECTLGYLD 2250

Query: 738  SLEEEGSLENADSTAMRNCLS----KIKAIGEELLPRGLDIKQEELGD------LVDKEM 787
             LE    +    +   +  L+    ++     EL+     +K  E  D      + + E+
Sbjct: 2251 LLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETEL 2310

Query: 788  AATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQRE 847
               +A+IE A  ++E++  +++       L+  E+IL    S+  A   L+ ++   QRE
Sbjct: 2311 LGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRE 2370

Query: 848  IVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCS 907
            +V  G+  + P    A + +W++GLISA++ V    + + +AA+  VQG    E+L+  +
Sbjct: 2371 LVAQGKVGSIPANA-ADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISSA 2429

Query: 908  HEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMD 967
             ++AASTAQL+ A KVKAD+DS  + +LQ A   V +A+  +V +         + D++ 
Sbjct: 2430 KQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVV 2489

Query: 968  FSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEG 1021
              +  +  I  Q + +Q  +L+ E EL++ R+KL ++R++ Y+        +EG
Sbjct: 2490 VKTKFVGGI-AQIIAAQEEMLKKERELEEARKKLAQIRQQQYKFLPTELREDEG 2542



 Score = 38.9 bits (89), Expect = 0.025
 Identities = 51/194 (26%), Positives = 78/194 (40%), Gaps = 48/194 (24%)

Query: 780 GDLVDKEMAATSAAIETATARIEEM---------LSKSRAGDTGVKLEVNERILGCCTSL 830
           GD  D +  A   AI T ++ + EM         L     G     L     + G  + L
Sbjct: 566 GDPADTDYTAVGCAITTISSNLTEMSKGVKLLAALMDDEVGSGEDLLRAARTLAGAVSDL 625

Query: 831 MQAIQ---------VLIVA------SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISA 875
           ++A+Q         VL  A      S DL R+I E+             + R+ + L+S 
Sbjct: 626 LKAVQPTSGEPRQTVLTAAGSIGQASGDLLRQIGEN-----------ETDERFQDVLMSL 674

Query: 876 SKAVGWGATVMV--------DAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADK 927
           +KAV   A ++V         A D V+Q R     ++  + + A ST+QLVA +KV +  
Sbjct: 675 AKAVANAAAMLVLKAKNVAQVAEDTVLQNR-----VIAAATQCALSTSQLVACAKVVSPT 729

Query: 928 DSPNLAQLQQASRG 941
            S  + Q Q    G
Sbjct: 730 ISSPVCQEQLIEAG 743


>gi|223029410 talin 1 [Homo sapiens]
          Length = 2541

 Score =  127 bits (319), Expect = 5e-29
 Identities = 156/641 (24%), Positives = 260/641 (40%), Gaps = 106/641 (16%)

Query: 461  AQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERI 520
            A  NE+  S +K +  EL    A L+ K          A Q        KKEL +   R+
Sbjct: 1906 AAENEEIGSHIKHRVQELGHGCAALVTKAG--------ALQCSPSDAYTKKELIECARRV 1957

Query: 521  SDQ----------GQRKTQEQLEVLESLKQELATSQRELQ-VLQGSL-----ETSAQSEA 564
            S++          G R TQ  +    ++   +A     +     G+L     ET A    
Sbjct: 1958 SEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHRE 2017

Query: 565  NWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS---------------TE 609
                    L ++   LV  AA  +E+L+   +    T  +LA                T+
Sbjct: 2018 GILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQ 2077

Query: 610  ESMCQLAKDQRKML--LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSC 667
              +    KD  K L  L+ + KAA   + D      +P +     SA  +++ VTS+   
Sbjct: 2078 VVLINAVKDVAKALGDLISATKAAAGKVGD------DPAVWQLKNSAKVMVTNVTSLLKT 2131

Query: 668  IEQLEKSWS--------------QYLAC------------PEDISGLLHSITLL------ 695
            ++ +E   +              Q LA             PED   +   IT+       
Sbjct: 2132 VKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVA 2191

Query: 696  -------------AHLTSDAIAHGATTCLRAP--PEPADSLTEACKQYGRETL-AYLASL 739
                         A+L+  AIA     C  A   PE A  +      YGRE    YL  L
Sbjct: 2192 AGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELL 2251

Query: 740  EEEGSLENADSTAMRNCLS----KIKAIGEELLPRGLDIKQEELGD------LVDKEMAA 789
            +         S  ++  L+    ++     EL+     +K  E  D      + + E+  
Sbjct: 2252 DHVLLTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLG 2311

Query: 790  TSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIV 849
             +AAIE A  ++E++  +++  +    L   E+IL    S+  A   L+ A+   QRE+V
Sbjct: 2312 AAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELV 2371

Query: 850  ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHE 909
              G+  A P      + +W++GLISA++ V      + +AA+  VQG    E+L+  + +
Sbjct: 2372 AQGKVGAIPANAL-DDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQ 2430

Query: 910  IAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFS 969
            +AASTAQL+ A KVKAD+DS  + +LQ A   V +A+  +V +     +  E+ +     
Sbjct: 2431 VAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVV 2490

Query: 970  SMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010
               +     Q + +Q  +L  E EL++ R+KL ++R++ Y+
Sbjct: 2491 KEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYK 2531



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 47/195 (24%), Positives = 88/195 (45%), Gaps = 24/195 (12%)

Query: 780 GDLVDKEMAATSAAIETATARIEEM---------LSKSRAGDTGVKLEVNERILGCCTSL 830
           GD  + +  A   A+ T ++ + EM         L +   G     L+  + + G  + L
Sbjct: 563 GDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSEL 622

Query: 831 MQAIQVLIVASKDLQREIVESGR--GTASPKEFYA-----KNSRWTEGLISASKAVGWGA 883
           +++ Q    AS + ++ ++++    G AS +          +  + + L+  +KAV   A
Sbjct: 623 LRSAQP---ASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALMQLAKAVASAA 679

Query: 884 TVMVDAADLVVQ---GRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLA--QLQQA 938
             +V  A  V Q     G   +++  + + A ST+QLVA +KV A   S  +   QL +A
Sbjct: 680 AALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEA 739

Query: 939 SRGVNQATAGVVAST 953
            R V +A  G V+++
Sbjct: 740 GRLVAKAVEGCVSAS 754


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%)

Query: 383  EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439
            E+    A+L++    K  + + + +L+GH+S+L+ DL  ++  R +A      L  EL+ 
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150

Query: 440  LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480
            L+ + EDT  +  +  E+  K +               ++E +  ++++K+++ V+    
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210

Query: 481  --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523
                          N   L ++NA++  ++ +  QA+ ++E +KK+LE  ++ +  +   
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270

Query: 524  GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562
            G+R          K Q ++E +             L +++A+   +LQ  Q  L+   + 
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330

Query: 563  EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612
            + N + +  +LE+ER+SL       +    + E  +S L  +L D++ KL   AST E++
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390

Query: 613  CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664
             +  K  +K +         + AA   ++   N+L++          D L   L     +
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1442

Query: 665  SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721
             S +E+ ++ + Q LA  ++IS         A   +   +  A      L    E  + L
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502

Query: 722  TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769
                K    E    ++S ++ G         + A  T M    ++++ + +EL       
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562

Query: 770  RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809
              L++  + L    ++++ A     E    +++  L                     K  
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622

Query: 810  AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868
             GD   ++L+ +  I G   ++ Q ++ L    KD QRE+ ++    AS  E +A     
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1677

Query: 869  TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928
                 +  KA    A +M    DL    R + ++  +   E+A   A  ++      D+ 
Sbjct: 1678 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1731

Query: 929  SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988
                A++ Q    + +    + A +   +   ++ + +  + +   +   Q+ +S  + L
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1790

Query: 989  ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036
            E +N+         ELR K +E+ G  +   + T    EA    L+E V ++
Sbjct: 1791 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%)

Query: 377  IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
            + R   E+   + +L+  K   Q+   +LK  + +  + L E+++L Q+       L AE
Sbjct: 847  VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 437  LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495
             +E+R R     ++ +  L E+E + +  E R  +L+ +  ++ Q   DL  +  E    
Sbjct: 906  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 496  VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555
                +  +V  E + K+LED +  + DQ  + ++E+ ++LE    +L T+  E +    +
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1024

Query: 556  LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
            L        +  +E             ELEK +  L   A+   E+++ L+ ++ + +++
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084

Query: 605  LASTEESM 612
            LA  EE +
Sbjct: 1085 LAKKEEEL 1092



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%)

Query: 431  EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
            E ++A+ DEL++ +E  +KA+  L E+E+K      + ++ K    E +Q   +L  +  
Sbjct: 852  EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 907

Query: 491  EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537
            E+  +++  +Q   +LE    E+E  LE   D+GQ+               +EQLE  E+
Sbjct: 908  EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 538  LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593
             +Q+L     T++ +++ L+  +          + E   LE+    L +  A  EE+   
Sbjct: 965  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024

Query: 594  LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
            L K        + + +++L   E+S  +L K +RK  L G      + I D   Q+ E  
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1082

Query: 647  LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706
            +   A   + L + +  +   I Q   +  +      ++ G  H   L   L S+  A  
Sbjct: 1083 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1135

Query: 707  ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
                 +A  +  D         G E  A    LE     +  DSTA +  L   +     
Sbjct: 1136 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1177

Query: 767  LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824
            +L + LD +       V +     + A+E  T ++E+   +K+        LE  N  + 
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237

Query: 825  GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884
            G    L QA Q +    K L+ ++ E     +  +   A+ +     L +  ++V    T
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1293

Query: 885  VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944
             M++ A+      GK  +L   + ++A+ ++QL         +D+  L Q ++  + +N 
Sbjct: 1294 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1334

Query: 945  ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004
            +T            Q+EE  N      +L     +EM+++     LE  +     +L + 
Sbjct: 1335 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1376

Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037
            +KK  + A   E  EEG +     ++ +  + E
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%)

Query: 324  EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381
            + +L  DD  +  + ++ L + +  D+  +    +    N     NK E     L  RL 
Sbjct: 985  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044

Query: 382  REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
            +E    + +LE +K + +         +++L+A +AE   L+ Q A   E L+A L  L 
Sbjct: 1045 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1099

Query: 442  RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
                D E AQ++                K++E    +     DL  + A   K     R 
Sbjct: 1100 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143

Query: 502  AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558
               +LE  K ELED+L+  + Q + + + + EV    ++L +E  + + ++Q ++     
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203

Query: 559  SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614
            + +       +F    A L+K + +L    A    EL  L +  Q+ + K    E  + +
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263

Query: 615  LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668
            L    +     G R  AE  + D +++L+         L    G A  L   V S+SS +
Sbjct: 1264 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317

Query: 669  EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728
            +  ++                    LL   T   +    +T LR   E  +SL +     
Sbjct: 1318 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1353

Query: 729  GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786
              E +    +LE   S  N   +  +  L    A   E L  G    Q+E+ +L    +E
Sbjct: 1354 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1410

Query: 787  MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846
             AA    +E    R+++ L      D  V L+   +++       +    L+   K++  
Sbjct: 1411 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465

Query: 847  EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905
            +   E  R  A  +E   K        +S ++A+        +        + + E+L+ 
Sbjct: 1466 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518

Query: 906  CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
               ++  +  +L     A + + ++    L +L+   +    A   +  +  + K Q E 
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578

Query: 963  TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010
                D  +     + KR+++  Q+   E E E +++++ L    KK  E
Sbjct: 1579 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%)

Query: 382  REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434
            R++   +  L++   E       L+ H+S L   L++ +   Q  A   E L       +
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398

Query: 435  AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480
             E++ L +Q E+   A   L + + + Q          + QR       K + K+ +L+ 
Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458

Query: 481  NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518
               ++  K A+             TK +S+AR      +A+ +LER  K    E+ED + 
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518

Query: 519  RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575
               D G+   + ++    LE+  +E+ T   EL+  LQ + +   + E N  A   + E+
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578

Query: 576  ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
            +   L +     EE+   L+++L   +T+L+    + ++   AK + +  L      A+ 
Sbjct: 1579 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 634  VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
             I   ++A+ QL          +  L     S D + +T        + LE   +  +  
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1692

Query: 682  PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
             ED++         A L  + +A    + L        S   A +   R   A +A LEE
Sbjct: 1693 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1743

Query: 742  EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778
            E   E  +  AM + + K     E+L                         + L  K  E
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803

Query: 779  LGDLVDKEMAATSAAIETATARIEEMLSK 807
            +   V  +  +T AA+E   A++EE + +
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%)

Query: 371  DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427
            ++ +    +L R++   + +LE+ + +         +L+G + +LE         R++A 
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 428  DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
                 L+A++ + +R+ ED   A+ S  EI   A+ NE++   L+          ADL++
Sbjct: 1645 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1691

Query: 488  KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
               ++       +QA ++ E   +EL  SL      G+   Q++   LE+    +A  + 
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1743

Query: 548  ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607
            EL+  QG++E  +        +  +L  E  +  S A   E     L ++ ++ + KL  
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803

Query: 608  TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638
             E ++    K     L     +  EQV Q+A
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%)

Query: 370  KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
            K E + ++  +   +   + + + ++ E +++  Q+     +LE + A +Q L+ +    
Sbjct: 917  KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976

Query: 430  CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489
               ++   DE+    +   K  +     ERK          L+E+ S+L  N A+   K 
Sbjct: 977  EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1022

Query: 490  AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539
              +T    K  SM  + +V L++E+K  +  + L+R  +       EQ+  L++    LK
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082

Query: 540  QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588
             +LA  + ELQ     L+     + N   +  ELE      ++ L S  A R        
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142

Query: 589  ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
               EEL AL+ EL+DT    A+ +E      + +R+  +   +KA ++  +    Q++E
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1196



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 64/281 (22%), Positives = 121/281 (43%), Gaps = 40/281 (14%)

Query: 372  EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
            EK+ L E L   +SG  A L++ K   +  + QL+  + E + ++       ++A    E
Sbjct: 1709 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767

Query: 432  FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487
             L    +EL  +R   +K + +  ++ER+   N++  SKL E      S+     A L  
Sbjct: 1768 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1821

Query: 488  KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELA 543
            K A++ +QV   AR+ Q     L+++ K+L++ L ++ D+  RK  EQ       K++  
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE--RKMAEQY------KEQAE 1873

Query: 544  TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603
                 ++ L+  LE + +      A   +L++E D           E++AL+ +L+    
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR---- 1929

Query: 604  KLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
                         +      +   R    +VI++A    EE
Sbjct: 1930 -------------RGNETSFVPSRRSGGRRVIENADGSEEE 1957


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%)

Query: 383  EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439
            E+    A+L++    K  + + + +L+GH+S+L+ DL  ++  R +A      L  EL+ 
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157

Query: 440  LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480
            L+ + EDT  +  +  E+  K +               ++E +  ++++K+++ V+    
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217

Query: 481  --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523
                          N   L ++NA++  ++ +  QA+ ++E +KK+LE  ++ +  +   
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277

Query: 524  GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562
            G+R          K Q ++E +             L +++A+   +LQ  Q  L+   + 
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337

Query: 563  EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612
            + N + +  +LE+ER+SL       +    + E  +S L  +L D++ KL   AST E++
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397

Query: 613  CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664
             +  K  +K +         + AA   ++   N+L++          D L   L     +
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1449

Query: 665  SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721
             S +E+ ++ + Q LA  ++IS         A   +   +  A      L    E  + L
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509

Query: 722  TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769
                K    E    ++S ++ G         + A  T M    ++++ + +EL       
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569

Query: 770  RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809
              L++  + L    ++++ A     E    +++  L                     K  
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629

Query: 810  AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868
             GD   ++L+ +  I G   ++ Q ++ L    KD QRE+ ++    AS  E +A     
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1684

Query: 869  TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928
                 +  KA    A +M    DL    R + ++  +   E+A   A  ++      D+ 
Sbjct: 1685 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1738

Query: 929  SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988
                A++ Q    + +    + A +   +   ++ + +  + +   +   Q+ +S  + L
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1797

Query: 989  ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036
            E +N+         ELR K +E+ G  +   + T    EA    L+E V ++
Sbjct: 1798 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%)

Query: 377  IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
            + R   E+   + +L+  K   Q+   +LK  + +  + L E+++L Q+       L AE
Sbjct: 854  VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 437  LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495
             +E+R R     ++ +  L E+E + +  E R  +L+ +  ++ Q   DL  +  E    
Sbjct: 913  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 496  VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555
                +  +V  E + K+LED +  + DQ  + ++E+ ++LE    +L T+  E +    +
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1031

Query: 556  LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
            L        +  +E             ELEK +  L   A+   E+++ L+ ++ + +++
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091

Query: 605  LASTEESM 612
            LA  EE +
Sbjct: 1092 LAKKEEEL 1099



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%)

Query: 431  EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
            E ++A+ DEL++ +E  +KA+  L E+E+K      + ++ K    E +Q   +L  +  
Sbjct: 859  EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 914

Query: 491  EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537
            E+  +++  +Q   +LE    E+E  LE   D+GQ+               +EQLE  E+
Sbjct: 915  EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 538  LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593
             +Q+L     T++ +++ L+  +          + E   LE+    L +  A  EE+   
Sbjct: 972  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031

Query: 594  LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
            L K        + + +++L   E+S  +L K +RK  L G      + I D   Q+ E  
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1089

Query: 647  LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706
            +   A   + L + +  +   I Q   +  +      ++ G  H   L   L S+  A  
Sbjct: 1090 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1142

Query: 707  ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
                 +A  +  D         G E  A    LE     +  DSTA +  L   +     
Sbjct: 1143 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1184

Query: 767  LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824
            +L + LD +       V +     + A+E  T ++E+   +K+        LE  N  + 
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244

Query: 825  GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884
            G    L QA Q +    K L+ ++ E     +  +   A+ +     L +  ++V    T
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1300

Query: 885  VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944
             M++ A+      GK  +L   + ++A+ ++QL         +D+  L Q ++  + +N 
Sbjct: 1301 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1341

Query: 945  ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004
            +T            Q+EE  N      +L     +EM+++     LE  +     +L + 
Sbjct: 1342 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1383

Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037
            +KK  + A   E  EEG +     ++ +  + E
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%)

Query: 324  EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381
            + +L  DD  +  + ++ L + +  D+  +    +    N     NK E     L  RL 
Sbjct: 992  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051

Query: 382  REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
            +E    + +LE +K + +         +++L+A +AE   L+ Q A   E L+A L  L 
Sbjct: 1052 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1106

Query: 442  RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
                D E AQ++                K++E    +     DL  + A   K     R 
Sbjct: 1107 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150

Query: 502  AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558
               +LE  K ELED+L+  + Q + + + + EV    ++L +E  + + ++Q ++     
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210

Query: 559  SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614
            + +       +F    A L+K + +L    A    EL  L +  Q+ + K    E  + +
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270

Query: 615  LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668
            L    +     G R  AE  + D +++L+         L    G A  L   V S+SS +
Sbjct: 1271 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324

Query: 669  EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728
            +  ++                    LL   T   +    +T LR   E  +SL +     
Sbjct: 1325 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1360

Query: 729  GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786
              E +    +LE   S  N   +  +  L    A   E L  G    Q+E+ +L    +E
Sbjct: 1361 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1417

Query: 787  MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846
             AA    +E    R+++ L      D  V L+   +++       +    L+   K++  
Sbjct: 1418 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472

Query: 847  EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905
            +   E  R  A  +E   K        +S ++A+        +        + + E+L+ 
Sbjct: 1473 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525

Query: 906  CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
               ++  +  +L     A + + ++    L +L+   +    A   +  +  + K Q E 
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585

Query: 963  TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010
                D  +     + KR+++  Q+   E E E +++++ L    KK  E
Sbjct: 1586 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%)

Query: 382  REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434
            R++   +  L++   E       L+ H+S L   L++ +   Q  A   E L       +
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405

Query: 435  AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480
             E++ L +Q E+   A   L + + + Q          + QR       K + K+ +L+ 
Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465

Query: 481  NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518
               ++  K A+             TK +S+AR      +A+ +LER  K    E+ED + 
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525

Query: 519  RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575
               D G+   + ++    LE+  +E+ T   EL+  LQ + +   + E N  A   + E+
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585

Query: 576  ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
            +   L +     EE+   L+++L   +T+L+    + ++   AK + +  L      A+ 
Sbjct: 1586 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 634  VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
             I   ++A+ QL          +  L     S D + +T        + LE   +  +  
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1699

Query: 682  PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
             ED++         A L  + +A    + L        S   A +   R   A +A LEE
Sbjct: 1700 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1750

Query: 742  EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778
            E   E  +  AM + + K     E+L                         + L  K  E
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810

Query: 779  LGDLVDKEMAATSAAIETATARIEEMLSK 807
            +   V  +  +T AA+E   A++EE + +
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%)

Query: 371  DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427
            ++ +    +L R++   + +LE+ + +         +L+G + +LE         R++A 
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 428  DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
                 L+A++ + +R+ ED   A+ S  EI   A+ NE++   L+          ADL++
Sbjct: 1652 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1698

Query: 488  KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
               ++       +QA ++ E   +EL  SL      G+   Q++   LE+    +A  + 
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1750

Query: 548  ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607
            EL+  QG++E  +        +  +L  E  +  S A   E     L ++ ++ + KL  
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810

Query: 608  TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638
             E ++    K     L     +  EQV Q+A
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%)

Query: 370  KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
            K E + ++  +   +   + + + ++ E +++  Q+     +LE + A +Q L+ +    
Sbjct: 924  KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983

Query: 430  CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489
               ++   DE+    +   K  +     ERK          L+E+ S+L  N A+   K 
Sbjct: 984  EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1029

Query: 490  AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539
              +T    K  SM  + +V L++E+K  +  + L+R  +       EQ+  L++    LK
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089

Query: 540  QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588
             +LA  + ELQ     L+     + N   +  ELE      ++ L S  A R        
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149

Query: 589  ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
               EEL AL+ EL+DT    A+ +E      + +R+  +   +KA ++  +    Q++E
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1203



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 64/281 (22%), Positives = 121/281 (43%), Gaps = 40/281 (14%)

Query: 372  EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
            EK+ L E L   +SG  A L++ K   +  + QL+  + E + ++       ++A    E
Sbjct: 1716 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774

Query: 432  FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487
             L    +EL  +R   +K + +  ++ER+   N++  SKL E      S+     A L  
Sbjct: 1775 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1828

Query: 488  KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELA 543
            K A++ +QV   AR+ Q     L+++ K+L++ L ++ D+  RK  EQ       K++  
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE--RKMAEQY------KEQAE 1880

Query: 544  TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603
                 ++ L+  LE + +      A   +L++E D           E++AL+ +L+    
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR---- 1936

Query: 604  KLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
                         +      +   R    +VI++A    EE
Sbjct: 1937 -------------RGNETSFVPSRRSGGRRVIENADGSEEE 1964


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%)

Query: 383  EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439
            E+    A+L++    K  + + + +L+GH+S+L+ DL  ++  R +A      L  EL+ 
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157

Query: 440  LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480
            L+ + EDT  +  +  E+  K +               ++E +  ++++K+++ V+    
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217

Query: 481  --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523
                          N   L ++NA++  ++ +  QA+ ++E +KK+LE  ++ +  +   
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277

Query: 524  GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562
            G+R          K Q ++E +             L +++A+   +LQ  Q  L+   + 
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337

Query: 563  EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612
            + N + +  +LE+ER+SL       +    + E  +S L  +L D++ KL   AST E++
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397

Query: 613  CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664
             +  K  +K +         + AA   ++   N+L++          D L   L     +
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1449

Query: 665  SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721
             S +E+ ++ + Q LA  ++IS         A   +   +  A      L    E  + L
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509

Query: 722  TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769
                K    E    ++S ++ G         + A  T M    ++++ + +EL       
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569

Query: 770  RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809
              L++  + L    ++++ A     E    +++  L                     K  
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629

Query: 810  AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868
             GD   ++L+ +  I G   ++ Q ++ L    KD QRE+ ++    AS  E +A     
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1684

Query: 869  TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928
                 +  KA    A +M    DL    R + ++  +   E+A   A  ++      D+ 
Sbjct: 1685 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1738

Query: 929  SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988
                A++ Q    + +    + A +   +   ++ + +  + +   +   Q+ +S  + L
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1797

Query: 989  ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036
            E +N+         ELR K +E+ G  +   + T    EA    L+E V ++
Sbjct: 1798 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%)

Query: 377  IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
            + R   E+   + +L+  K   Q+   +LK  + +  + L E+++L Q+       L AE
Sbjct: 854  VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 437  LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495
             +E+R R     ++ +  L E+E + +  E R  +L+ +  ++ Q   DL  +  E    
Sbjct: 913  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 496  VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555
                +  +V  E + K+LED +  + DQ  + ++E+ ++LE    +L T+  E +    +
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1031

Query: 556  LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
            L        +  +E             ELEK +  L   A+   E+++ L+ ++ + +++
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091

Query: 605  LASTEESM 612
            LA  EE +
Sbjct: 1092 LAKKEEEL 1099



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%)

Query: 431  EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
            E ++A+ DEL++ +E  +KA+  L E+E+K      + ++ K    E +Q   +L  +  
Sbjct: 859  EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 914

Query: 491  EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537
            E+  +++  +Q   +LE    E+E  LE   D+GQ+               +EQLE  E+
Sbjct: 915  EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 538  LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593
             +Q+L     T++ +++ L+  +          + E   LE+    L +  A  EE+   
Sbjct: 972  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031

Query: 594  LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
            L K        + + +++L   E+S  +L K +RK  L G      + I D   Q+ E  
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1089

Query: 647  LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706
            +   A   + L + +  +   I Q   +  +      ++ G  H   L   L S+  A  
Sbjct: 1090 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1142

Query: 707  ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
                 +A  +  D         G E  A    LE     +  DSTA +  L   +     
Sbjct: 1143 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1184

Query: 767  LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824
            +L + LD +       V +     + A+E  T ++E+   +K+        LE  N  + 
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244

Query: 825  GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884
            G    L QA Q +    K L+ ++ E     +  +   A+ +     L +  ++V    T
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1300

Query: 885  VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944
             M++ A+      GK  +L   + ++A+ ++QL         +D+  L Q ++  + +N 
Sbjct: 1301 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1341

Query: 945  ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004
            +T            Q+EE  N      +L     +EM+++     LE  +     +L + 
Sbjct: 1342 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1383

Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037
            +KK  + A   E  EEG +     ++ +  + E
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%)

Query: 324  EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381
            + +L  DD  +  + ++ L + +  D+  +    +    N     NK E     L  RL 
Sbjct: 992  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051

Query: 382  REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
            +E    + +LE +K + +         +++L+A +AE   L+ Q A   E L+A L  L 
Sbjct: 1052 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1106

Query: 442  RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
                D E AQ++                K++E    +     DL  + A   K     R 
Sbjct: 1107 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150

Query: 502  AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558
               +LE  K ELED+L+  + Q + + + + EV    ++L +E  + + ++Q ++     
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210

Query: 559  SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614
            + +       +F    A L+K + +L    A    EL  L +  Q+ + K    E  + +
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270

Query: 615  LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668
            L    +     G R  AE  + D +++L+         L    G A  L   V S+SS +
Sbjct: 1271 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324

Query: 669  EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728
            +  ++                    LL   T   +    +T LR   E  +SL +     
Sbjct: 1325 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1360

Query: 729  GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786
              E +    +LE   S  N   +  +  L    A   E L  G    Q+E+ +L    +E
Sbjct: 1361 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1417

Query: 787  MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846
             AA    +E    R+++ L      D  V L+   +++       +    L+   K++  
Sbjct: 1418 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472

Query: 847  EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905
            +   E  R  A  +E   K        +S ++A+        +        + + E+L+ 
Sbjct: 1473 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525

Query: 906  CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
               ++  +  +L     A + + ++    L +L+   +    A   +  +  + K Q E 
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585

Query: 963  TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010
                D  +     + KR+++  Q+   E E E +++++ L    KK  E
Sbjct: 1586 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%)

Query: 382  REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434
            R++   +  L++   E       L+ H+S L   L++ +   Q  A   E L       +
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405

Query: 435  AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480
             E++ L +Q E+   A   L + + + Q          + QR       K + K+ +L+ 
Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465

Query: 481  NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518
               ++  K A+             TK +S+AR      +A+ +LER  K    E+ED + 
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525

Query: 519  RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575
               D G+   + ++    LE+  +E+ T   EL+  LQ + +   + E N  A   + E+
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585

Query: 576  ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
            +   L +     EE+   L+++L   +T+L+    + ++   AK + +  L      A+ 
Sbjct: 1586 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 634  VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
             I   ++A+ QL          +  L     S D + +T        + LE   +  +  
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1699

Query: 682  PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
             ED++         A L  + +A    + L        S   A +   R   A +A LEE
Sbjct: 1700 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1750

Query: 742  EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778
            E   E  +  AM + + K     E+L                         + L  K  E
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810

Query: 779  LGDLVDKEMAATSAAIETATARIEEMLSK 807
            +   V  +  +T AA+E   A++EE + +
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%)

Query: 371  DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427
            ++ +    +L R++   + +LE+ + +         +L+G + +LE         R++A 
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 428  DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
                 L+A++ + +R+ ED   A+ S  EI   A+ NE++   L+          ADL++
Sbjct: 1652 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1698

Query: 488  KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
               ++       +QA ++ E   +EL  SL      G+   Q++   LE+    +A  + 
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1750

Query: 548  ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607
            EL+  QG++E  +        +  +L  E  +  S A   E     L ++ ++ + KL  
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810

Query: 608  TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638
             E ++    K     L     +  EQV Q+A
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%)

Query: 370  KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
            K E + ++  +   +   + + + ++ E +++  Q+     +LE + A +Q L+ +    
Sbjct: 924  KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983

Query: 430  CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489
               ++   DE+    +   K  +     ERK          L+E+ S+L  N A+   K 
Sbjct: 984  EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1029

Query: 490  AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539
              +T    K  SM  + +V L++E+K  +  + L+R  +       EQ+  L++    LK
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089

Query: 540  QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588
             +LA  + ELQ     L+     + N   +  ELE      ++ L S  A R        
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149

Query: 589  ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
               EEL AL+ EL+DT    A+ +E      + +R+  +   +KA ++  +    Q++E
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1203



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 50/203 (24%), Positives = 95/203 (46%), Gaps = 31/203 (15%)

Query: 372  EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
            EK+ L E L   +SG  A L++ K   +  + QL+  + E + ++       ++A    E
Sbjct: 1716 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774

Query: 432  FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487
             L    +EL  +R   +K + +  ++ER+   N++  SKL E      S+     A L  
Sbjct: 1775 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1828

Query: 488  KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQ----------------RK 527
            K A++ +QV   AR+ Q     L+++ K+L++ L ++ D+ +                ++
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888

Query: 528  TQEQLEVLESLKQELATSQRELQ 550
             + QLE  E   Q +  ++R+LQ
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQ 1911


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%)

Query: 383  EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439
            E+    A+L++    K  + + + +L+GH+S+L+ DL  ++  R +A      L  EL+ 
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150

Query: 440  LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480
            L+ + EDT  +  +  E+  K +               ++E +  ++++K+++ V+    
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210

Query: 481  --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523
                          N   L ++NA++  ++ +  QA+ ++E +KK+LE  ++ +  +   
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270

Query: 524  GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562
            G+R          K Q ++E +             L +++A+   +LQ  Q  L+   + 
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330

Query: 563  EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612
            + N + +  +LE+ER+SL       +    + E  +S L  +L D++ KL   AST E++
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390

Query: 613  CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664
             +  K  +K +         + AA   ++   N+L++          D L   L     +
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1442

Query: 665  SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721
             S +E+ ++ + Q LA  ++IS         A   +   +  A      L    E  + L
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502

Query: 722  TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769
                K    E    ++S ++ G         + A  T M    ++++ + +EL       
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562

Query: 770  RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809
              L++  + L    ++++ A     E    +++  L                     K  
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622

Query: 810  AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868
             GD   ++L+ +  I G   ++ Q ++ L    KD QRE+ ++    AS  E +A     
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1677

Query: 869  TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928
                 +  KA    A +M    DL    R + ++  +   E+A   A  ++      D+ 
Sbjct: 1678 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1731

Query: 929  SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988
                A++ Q    + +    + A +   +   ++ + +  + +   +   Q+ +S  + L
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1790

Query: 989  ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036
            E +N+         ELR K +E+ G  +   + T    EA    L+E V ++
Sbjct: 1791 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%)

Query: 377  IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
            + R   E+   + +L+  K   Q+   +LK  + +  + L E+++L Q+       L AE
Sbjct: 847  VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 437  LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495
             +E+R R     ++ +  L E+E + +  E R  +L+ +  ++ Q   DL  +  E    
Sbjct: 906  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 496  VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555
                +  +V  E + K+LED +  + DQ  + ++E+ ++LE    +L T+  E +    +
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1024

Query: 556  LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
            L        +  +E             ELEK +  L   A+   E+++ L+ ++ + +++
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084

Query: 605  LASTEESM 612
            LA  EE +
Sbjct: 1085 LAKKEEEL 1092



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%)

Query: 431  EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
            E ++A+ DEL++ +E  +KA+  L E+E+K      + ++ K    E +Q   +L  +  
Sbjct: 852  EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 907

Query: 491  EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537
            E+  +++  +Q   +LE    E+E  LE   D+GQ+               +EQLE  E+
Sbjct: 908  EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 538  LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593
             +Q+L     T++ +++ L+  +          + E   LE+    L +  A  EE+   
Sbjct: 965  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024

Query: 594  LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
            L K        + + +++L   E+S  +L K +RK  L G      + I D   Q+ E  
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1082

Query: 647  LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706
            +   A   + L + +  +   I Q   +  +      ++ G  H   L   L S+  A  
Sbjct: 1083 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1135

Query: 707  ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
                 +A  +  D         G E  A    LE     +  DSTA +  L   +     
Sbjct: 1136 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1177

Query: 767  LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824
            +L + LD +       V +     + A+E  T ++E+   +K+        LE  N  + 
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237

Query: 825  GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884
            G    L QA Q +    K L+ ++ E     +  +   A+ +     L +  ++V    T
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1293

Query: 885  VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944
             M++ A+      GK  +L   + ++A+ ++QL         +D+  L Q ++  + +N 
Sbjct: 1294 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1334

Query: 945  ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004
            +T            Q+EE  N      +L     +EM+++     LE  +     +L + 
Sbjct: 1335 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1376

Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037
            +KK  + A   E  EEG +     ++ +  + E
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%)

Query: 324  EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381
            + +L  DD  +  + ++ L + +  D+  +    +    N     NK E     L  RL 
Sbjct: 985  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044

Query: 382  REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
            +E    + +LE +K + +         +++L+A +AE   L+ Q A   E L+A L  L 
Sbjct: 1045 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1099

Query: 442  RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
                D E AQ++                K++E    +     DL  + A   K     R 
Sbjct: 1100 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143

Query: 502  AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558
               +LE  K ELED+L+  + Q + + + + EV    ++L +E  + + ++Q ++     
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203

Query: 559  SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614
            + +       +F    A L+K + +L    A    EL  L +  Q+ + K    E  + +
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263

Query: 615  LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668
            L    +     G R  AE  + D +++L+         L    G A  L   V S+SS +
Sbjct: 1264 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317

Query: 669  EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728
            +  ++                    LL   T   +    +T LR   E  +SL +     
Sbjct: 1318 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1353

Query: 729  GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786
              E +    +LE   S  N   +  +  L    A   E L  G    Q+E+ +L    +E
Sbjct: 1354 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1410

Query: 787  MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846
             AA    +E    R+++ L      D  V L+   +++       +    L+   K++  
Sbjct: 1411 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465

Query: 847  EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905
            +   E  R  A  +E   K        +S ++A+        +        + + E+L+ 
Sbjct: 1466 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518

Query: 906  CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
               ++  +  +L     A + + ++    L +L+   +    A   +  +  + K Q E 
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578

Query: 963  TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010
                D  +     + KR+++  Q+   E E E +++++ L    KK  E
Sbjct: 1579 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%)

Query: 382  REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434
            R++   +  L++   E       L+ H+S L   L++ +   Q  A   E L       +
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398

Query: 435  AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480
             E++ L +Q E+   A   L + + + Q          + QR       K + K+ +L+ 
Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458

Query: 481  NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518
               ++  K A+             TK +S+AR      +A+ +LER  K    E+ED + 
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518

Query: 519  RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575
               D G+   + ++    LE+  +E+ T   EL+  LQ + +   + E N  A   + E+
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578

Query: 576  ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
            +   L +     EE+   L+++L   +T+L+    + ++   AK + +  L      A+ 
Sbjct: 1579 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 634  VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
             I   ++A+ QL          +  L     S D + +T        + LE   +  +  
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1692

Query: 682  PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
             ED++         A L  + +A    + L        S   A +   R   A +A LEE
Sbjct: 1693 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1743

Query: 742  EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778
            E   E  +  AM + + K     E+L                         + L  K  E
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803

Query: 779  LGDLVDKEMAATSAAIETATARIEEMLSK 807
            +   V  +  +T AA+E   A++EE + +
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%)

Query: 371  DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427
            ++ +    +L R++   + +LE+ + +         +L+G + +LE         R++A 
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 428  DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
                 L+A++ + +R+ ED   A+ S  EI   A+ NE++   L+          ADL++
Sbjct: 1645 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1691

Query: 488  KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
               ++       +QA ++ E   +EL  SL      G+   Q++   LE+    +A  + 
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1743

Query: 548  ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607
            EL+  QG++E  +        +  +L  E  +  S A   E     L ++ ++ + KL  
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803

Query: 608  TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638
             E ++    K     L     +  EQV Q+A
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%)

Query: 370  KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
            K E + ++  +   +   + + + ++ E +++  Q+     +LE + A +Q L+ +    
Sbjct: 917  KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976

Query: 430  CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489
               ++   DE+    +   K  +     ERK          L+E+ S+L  N A+   K 
Sbjct: 977  EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1022

Query: 490  AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539
              +T    K  SM  + +V L++E+K  +  + L+R  +       EQ+  L++    LK
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082

Query: 540  QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588
             +LA  + ELQ     L+     + N   +  ELE      ++ L S  A R        
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142

Query: 589  ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
               EEL AL+ EL+DT    A+ +E      + +R+  +   +KA ++  +    Q++E
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1196



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 50/203 (24%), Positives = 95/203 (46%), Gaps = 31/203 (15%)

Query: 372  EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
            EK+ L E L   +SG  A L++ K   +  + QL+  + E + ++       ++A    E
Sbjct: 1709 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767

Query: 432  FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487
             L    +EL  +R   +K + +  ++ER+   N++  SKL E      S+     A L  
Sbjct: 1768 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1821

Query: 488  KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQ----------------RK 527
            K A++ +QV   AR+ Q     L+++ K+L++ L ++ D+ +                ++
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881

Query: 528  TQEQLEVLESLKQELATSQRELQ 550
             + QLE  E   Q +  ++R+LQ
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQ 1904


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 141/709 (19%), Positives = 267/709 (37%), Gaps = 124/709 (17%)

Query: 364  SQNGVNKDEKDHLIERLYREISGLKAQLENM-------KTESQRVVLQLKGHVSELEADL 416
            S     ++EK   + +L  +     A +E+        + E +++  +L G  SEL+  +
Sbjct: 1037 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1096

Query: 417  AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS 476
             EQQ   ++       LRA+L          E+ Q +L+  E +  A  Q    L+E  +
Sbjct: 1097 VEQQQRAEE-------LRAQLGRKE------EELQAALARAEDEGGARAQLLKSLREAQA 1143

Query: 477  ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ---RKTQEQLE 533
             L +   DL  +    TK     R    +LE  + ELED+L+  + Q +   ++ QE  E
Sbjct: 1144 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1203

Query: 534  VLESLKQELATSQRELQVLQ-----------GSLETSAQSEANW-------AAEFAELEK 575
            + ++L++E    +  +Q L+             LE + + +  W        AE +EL  
Sbjct: 1204 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1263

Query: 576  ERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVI 635
            E  SL +     E+    L  +LQ+ Q +    E +  + A+  ++       +A  + +
Sbjct: 1264 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR------AQAELENV 1317

Query: 636  QDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695
              ALN+ E   +      +  L ST   +    E L++     LA    +  +       
Sbjct: 1318 SGALNEAESKTI----RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM------- 1366

Query: 696  AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASL--------EEEGSLEN 747
                 +A A G         E  +    A ++ GRE     A L        EE G+LE 
Sbjct: 1367 -----EAEAAGLR-------EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1413

Query: 748  ADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSK 807
            A   A R    + +A+ + L                  E   T   +E    R+++ L  
Sbjct: 1414 AGEEARRRAAREAEALTQRL-----------------AEKTETVDRLERGRRRLQQELD- 1455

Query: 808  SRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK-DLQREIVESGRGTASPKEFYAKNS 866
                D  + LE   +++       +    L+   K  + R + E  R  A  +E  A+  
Sbjct: 1456 ----DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1511

Query: 867  RWTEGLISASKAVGWGATVMVDAADLVVQG---RGKFEELMVCSHEIAASTAQLVAASKV 923
              T  L    +A            +L  Q    R + E L+    ++  S  +L  A +V
Sbjct: 1512 SLTRALEEEQEA----------REELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1561

Query: 924  KADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDS 983
                 +   AQ+ +    +  A    +   ++ ++   + +          + +R+++  
Sbjct: 1562 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1621

Query: 984  QVRVLELENELQKERQKL---------GELRKKHYELAGVAEGWEEGTE 1023
            Q+R  E+E + +++++ L         GEL +   ++A   +G EE  +
Sbjct: 1622 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1670



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 78/337 (23%), Positives = 141/337 (41%), Gaps = 58/337 (17%)

Query: 379  RLYREISGLKAQ----LENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLR 434
            RL   +  LK Q    L+      +    QL   + + E +  E++  R  A    + L 
Sbjct: 1589 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1648

Query: 435  AELDELRRQ-------REDTEKAQRSLS--------EIERKAQANEQRYSKLKEKYSELV 479
             EL+EL+ Q       +E+  K  R +         E+E    + E+ +S+ +E    L 
Sbjct: 1649 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1708

Query: 480  QNHADLLRKNAEVTKQVSMARQAQVDLE-----------------REKKELEDSLERISD 522
               A++LR   E+       RQAQ D +                  EK++LE  L ++  
Sbjct: 1709 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL-- 1766

Query: 523  QGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF----AELEKERD 578
                  +E+LE  +S  + L    R+L +   SL T   +E +++A+      +LE++  
Sbjct: 1767 ------EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1820

Query: 579  SLVSGAAHREEELSALRK-ELQDTQLKLASTEESMCQLAKDQRKMLLVGSR-KAAEQVIQ 636
             L       +    A  K  +   + KLA  EE   QL ++ R+ +L G   + AE+ ++
Sbjct: 1821 ELRGRLGEEDAGARARHKMTIAALESKLAQAEE---QLEQETRERILSGKLVRRAEKRLK 1877

Query: 637  DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673
            + + Q+EE   +     AD L   +   +  ++QL++
Sbjct: 1878 EVVLQVEEERRV-----ADQLRDQLEKGNLRVKQLKR 1909



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 131/637 (20%), Positives = 248/637 (38%), Gaps = 113/637 (17%)

Query: 390  QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTE 448
            +++ ++ +S R V +L+G V++LE    E+  L +Q   + E L AE +E R R     +
Sbjct: 888  KVQELQQQSAREVGELQGRVAQLE---EERARLAEQLRAEAE-LCAEAEETRGRLAARKQ 943

Query: 449  KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ-VDLE 507
            + +  +SE+E +    E+  S+  +   + +Q H   L  + E  +      Q + V  E
Sbjct: 944  ELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 1002

Query: 508  REKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWA 567
             + K+ E+ L  + DQ  + ++E+  + + L +  + +  E + ++   +   + EA  A
Sbjct: 1003 AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1062

Query: 568  AEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGS 627
                 L KE            +EL  L++ L     +L        Q A++ R  L    
Sbjct: 1063 DMEDRLRKEEKG--------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL---G 1111

Query: 628  RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISG 687
            RK  E+ +Q AL + E+       G+   LL ++    + + + ++              
Sbjct: 1112 RK--EEELQAALARAEDE-----GGARAQLLKSLREAQAALAEAQED------------- 1151

Query: 688  LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQ---YGRETLAYLASLEEEGS 744
                      L S+ +A                 T+A KQ    G E  A    LE    
Sbjct: 1152 ----------LESERVAR----------------TKAEKQRRDLGEELEALRGELE---- 1181

Query: 745  LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804
             +  DST   N   ++++  E+        +  EL   +++E     AA++    R  + 
Sbjct: 1182 -DTLDST---NAQQELRSKREQ--------EVTELKKTLEEETRIHEAAVQELRQRHGQA 1229

Query: 805  LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864
            L     G+   +LE   R  G       A++  +    +L+ E+  S   TA  +E   +
Sbjct: 1230 L-----GELAEQLEQARRGKGAWEKTRLALEAEV---SELRAEL--SSLQTAR-QEGEQR 1278

Query: 865  NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924
              R    L       G G     +AA+ + + + + E +    +E  + T +L       
Sbjct: 1279 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL------- 1331

Query: 925  ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQ 984
            + + S   AQL  A   + + T   +A     ++   E   +           R++++ +
Sbjct: 1332 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL-----------REQLEEE 1380

Query: 985  VRVLE-LENELQKERQKLGELRKKHYELAGVAEGWEE 1020
                E    ELQ  + +L E R++  E AG  E  EE
Sbjct: 1381 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEE 1417


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 141/709 (19%), Positives = 267/709 (37%), Gaps = 124/709 (17%)

Query: 364  SQNGVNKDEKDHLIERLYREISGLKAQLENM-------KTESQRVVLQLKGHVSELEADL 416
            S     ++EK   + +L  +     A +E+        + E +++  +L G  SEL+  +
Sbjct: 1029 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1088

Query: 417  AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS 476
             EQQ   ++       LRA+L          E+ Q +L+  E +  A  Q    L+E  +
Sbjct: 1089 VEQQQRAEE-------LRAQLGRKE------EELQAALARAEDEGGARAQLLKSLREAQA 1135

Query: 477  ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ---RKTQEQLE 533
             L +   DL  +    TK     R    +LE  + ELED+L+  + Q +   ++ QE  E
Sbjct: 1136 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1195

Query: 534  VLESLKQELATSQRELQVLQ-----------GSLETSAQSEANW-------AAEFAELEK 575
            + ++L++E    +  +Q L+             LE + + +  W        AE +EL  
Sbjct: 1196 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1255

Query: 576  ERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVI 635
            E  SL +     E+    L  +LQ+ Q +    E +  + A+  ++       +A  + +
Sbjct: 1256 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR------AQAELENV 1309

Query: 636  QDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695
              ALN+ E   +      +  L ST   +    E L++     LA    +  +       
Sbjct: 1310 SGALNEAESKTI----RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM------- 1358

Query: 696  AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASL--------EEEGSLEN 747
                 +A A G         E  +    A ++ GRE     A L        EE G+LE 
Sbjct: 1359 -----EAEAAGLR-------EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1405

Query: 748  ADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSK 807
            A   A R    + +A+ + L                  E   T   +E    R+++ L  
Sbjct: 1406 AGEEARRRAAREAEALTQRL-----------------AEKTETVDRLERGRRRLQQELD- 1447

Query: 808  SRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK-DLQREIVESGRGTASPKEFYAKNS 866
                D  + LE   +++       +    L+   K  + R + E  R  A  +E  A+  
Sbjct: 1448 ----DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1503

Query: 867  RWTEGLISASKAVGWGATVMVDAADLVVQG---RGKFEELMVCSHEIAASTAQLVAASKV 923
              T  L    +A            +L  Q    R + E L+    ++  S  +L  A +V
Sbjct: 1504 SLTRALEEEQEA----------REELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1553

Query: 924  KADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDS 983
                 +   AQ+ +    +  A    +   ++ ++   + +          + +R+++  
Sbjct: 1554 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1613

Query: 984  QVRVLELENELQKERQKL---------GELRKKHYELAGVAEGWEEGTE 1023
            Q+R  E+E + +++++ L         GEL +   ++A   +G EE  +
Sbjct: 1614 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1662



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 78/337 (23%), Positives = 141/337 (41%), Gaps = 58/337 (17%)

Query: 379  RLYREISGLKAQ----LENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLR 434
            RL   +  LK Q    L+      +    QL   + + E +  E++  R  A    + L 
Sbjct: 1581 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1640

Query: 435  AELDELRRQ-------REDTEKAQRSLS--------EIERKAQANEQRYSKLKEKYSELV 479
             EL+EL+ Q       +E+  K  R +         E+E    + E+ +S+ +E    L 
Sbjct: 1641 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1700

Query: 480  QNHADLLRKNAEVTKQVSMARQAQVDLE-----------------REKKELEDSLERISD 522
               A++LR   E+       RQAQ D +                  EK++LE  L ++  
Sbjct: 1701 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL-- 1758

Query: 523  QGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF----AELEKERD 578
                  +E+LE  +S  + L    R+L +   SL T   +E +++A+      +LE++  
Sbjct: 1759 ------EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1812

Query: 579  SLVSGAAHREEELSALRK-ELQDTQLKLASTEESMCQLAKDQRKMLLVGSR-KAAEQVIQ 636
             L       +    A  K  +   + KLA  EE   QL ++ R+ +L G   + AE+ ++
Sbjct: 1813 ELRGRLGEEDAGARARHKMTIAALESKLAQAEE---QLEQETRERILSGKLVRRAEKRLK 1869

Query: 637  DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673
            + + Q+EE   +     AD L   +   +  ++QL++
Sbjct: 1870 EVVLQVEEERRV-----ADQLRDQLEKGNLRVKQLKR 1901



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 131/637 (20%), Positives = 248/637 (38%), Gaps = 113/637 (17%)

Query: 390  QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTE 448
            +++ ++ +S R V +L+G V++LE    E+  L +Q   + E L AE +E R R     +
Sbjct: 880  KVQELQQQSAREVGELQGRVAQLE---EERARLAEQLRAEAE-LCAEAEETRGRLAARKQ 935

Query: 449  KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ-VDLE 507
            + +  +SE+E +    E+  S+  +   + +Q H   L  + E  +      Q + V  E
Sbjct: 936  ELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 994

Query: 508  REKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWA 567
             + K+ E+ L  + DQ  + ++E+  + + L +  + +  E + ++   +   + EA  A
Sbjct: 995  AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1054

Query: 568  AEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGS 627
                 L KE            +EL  L++ L     +L        Q A++ R  L    
Sbjct: 1055 DMEDRLRKEEKG--------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL---G 1103

Query: 628  RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISG 687
            RK  E+ +Q AL + E+       G+   LL ++    + + + ++              
Sbjct: 1104 RK--EEELQAALARAEDE-----GGARAQLLKSLREAQAALAEAQED------------- 1143

Query: 688  LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQ---YGRETLAYLASLEEEGS 744
                      L S+ +A                 T+A KQ    G E  A    LE    
Sbjct: 1144 ----------LESERVAR----------------TKAEKQRRDLGEELEALRGELE---- 1173

Query: 745  LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804
             +  DST   N   ++++  E+        +  EL   +++E     AA++    R  + 
Sbjct: 1174 -DTLDST---NAQQELRSKREQ--------EVTELKKTLEEETRIHEAAVQELRQRHGQA 1221

Query: 805  LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864
            L     G+   +LE   R  G       A++  +    +L+ E+  S   TA  +E   +
Sbjct: 1222 L-----GELAEQLEQARRGKGAWEKTRLALEAEV---SELRAEL--SSLQTAR-QEGEQR 1270

Query: 865  NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924
              R    L       G G     +AA+ + + + + E +    +E  + T +L       
Sbjct: 1271 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL------- 1323

Query: 925  ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQ 984
            + + S   AQL  A   + + T   +A     ++   E   +           R++++ +
Sbjct: 1324 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL-----------REQLEEE 1372

Query: 985  VRVLE-LENELQKERQKLGELRKKHYELAGVAEGWEE 1020
                E    ELQ  + +L E R++  E AG  E  EE
Sbjct: 1373 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEE 1409


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 141/709 (19%), Positives = 267/709 (37%), Gaps = 124/709 (17%)

Query: 364  SQNGVNKDEKDHLIERLYREISGLKAQLENM-------KTESQRVVLQLKGHVSELEADL 416
            S     ++EK   + +L  +     A +E+        + E +++  +L G  SEL+  +
Sbjct: 1070 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1129

Query: 417  AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS 476
             EQQ   ++       LRA+L          E+ Q +L+  E +  A  Q    L+E  +
Sbjct: 1130 VEQQQRAEE-------LRAQLGRKE------EELQAALARAEDEGGARAQLLKSLREAQA 1176

Query: 477  ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ---RKTQEQLE 533
             L +   DL  +    TK     R    +LE  + ELED+L+  + Q +   ++ QE  E
Sbjct: 1177 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1236

Query: 534  VLESLKQELATSQRELQVLQ-----------GSLETSAQSEANW-------AAEFAELEK 575
            + ++L++E    +  +Q L+             LE + + +  W        AE +EL  
Sbjct: 1237 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1296

Query: 576  ERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVI 635
            E  SL +     E+    L  +LQ+ Q +    E +  + A+  ++       +A  + +
Sbjct: 1297 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR------AQAELENV 1350

Query: 636  QDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695
              ALN+ E   +      +  L ST   +    E L++     LA    +  +       
Sbjct: 1351 SGALNEAESKTI----RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM------- 1399

Query: 696  AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASL--------EEEGSLEN 747
                 +A A G         E  +    A ++ GRE     A L        EE G+LE 
Sbjct: 1400 -----EAEAAGLR-------EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1446

Query: 748  ADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSK 807
            A   A R    + +A+ + L                  E   T   +E    R+++ L  
Sbjct: 1447 AGEEARRRAAREAEALTQRL-----------------AEKTETVDRLERGRRRLQQELD- 1488

Query: 808  SRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK-DLQREIVESGRGTASPKEFYAKNS 866
                D  + LE   +++       +    L+   K  + R + E  R  A  +E  A+  
Sbjct: 1489 ----DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1544

Query: 867  RWTEGLISASKAVGWGATVMVDAADLVVQG---RGKFEELMVCSHEIAASTAQLVAASKV 923
              T  L    +A            +L  Q    R + E L+    ++  S  +L  A +V
Sbjct: 1545 SLTRALEEEQEA----------REELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1594

Query: 924  KADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDS 983
                 +   AQ+ +    +  A    +   ++ ++   + +          + +R+++  
Sbjct: 1595 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1654

Query: 984  QVRVLELENELQKERQKL---------GELRKKHYELAGVAEGWEEGTE 1023
            Q+R  E+E + +++++ L         GEL +   ++A   +G EE  +
Sbjct: 1655 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1703



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 78/337 (23%), Positives = 141/337 (41%), Gaps = 58/337 (17%)

Query: 379  RLYREISGLKAQ----LENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLR 434
            RL   +  LK Q    L+      +    QL   + + E +  E++  R  A    + L 
Sbjct: 1622 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1681

Query: 435  AELDELRRQ-------REDTEKAQRSLS--------EIERKAQANEQRYSKLKEKYSELV 479
             EL+EL+ Q       +E+  K  R +         E+E    + E+ +S+ +E    L 
Sbjct: 1682 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1741

Query: 480  QNHADLLRKNAEVTKQVSMARQAQVDLE-----------------REKKELEDSLERISD 522
               A++LR   E+       RQAQ D +                  EK++LE  L ++  
Sbjct: 1742 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL-- 1799

Query: 523  QGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF----AELEKERD 578
                  +E+LE  +S  + L    R+L +   SL T   +E +++A+      +LE++  
Sbjct: 1800 ------EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1853

Query: 579  SLVSGAAHREEELSALRK-ELQDTQLKLASTEESMCQLAKDQRKMLLVGSR-KAAEQVIQ 636
             L       +    A  K  +   + KLA  EE   QL ++ R+ +L G   + AE+ ++
Sbjct: 1854 ELRGRLGEEDAGARARHKMTIAALESKLAQAEE---QLEQETRERILSGKLVRRAEKRLK 1910

Query: 637  DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673
            + + Q+EE   +     AD L   +   +  ++QL++
Sbjct: 1911 EVVLQVEEERRV-----ADQLRDQLEKGNLRVKQLKR 1942



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 131/637 (20%), Positives = 248/637 (38%), Gaps = 113/637 (17%)

Query: 390  QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTE 448
            +++ ++ +S R V +L+G V++LE    E+  L +Q   + E L AE +E R R     +
Sbjct: 921  KVQELQQQSAREVGELQGRVAQLE---EERARLAEQLRAEAE-LCAEAEETRGRLAARKQ 976

Query: 449  KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ-VDLE 507
            + +  +SE+E +    E+  S+  +   + +Q H   L  + E  +      Q + V  E
Sbjct: 977  ELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 1035

Query: 508  REKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWA 567
             + K+ E+ L  + DQ  + ++E+  + + L +  + +  E + ++   +   + EA  A
Sbjct: 1036 AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1095

Query: 568  AEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGS 627
                 L KE            +EL  L++ L     +L        Q A++ R  L    
Sbjct: 1096 DMEDRLRKEEKG--------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL---G 1144

Query: 628  RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISG 687
            RK  E+ +Q AL + E+       G+   LL ++    + + + ++              
Sbjct: 1145 RK--EEELQAALARAEDE-----GGARAQLLKSLREAQAALAEAQED------------- 1184

Query: 688  LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQ---YGRETLAYLASLEEEGS 744
                      L S+ +A                 T+A KQ    G E  A    LE    
Sbjct: 1185 ----------LESERVAR----------------TKAEKQRRDLGEELEALRGELE---- 1214

Query: 745  LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804
             +  DST   N   ++++  E+        +  EL   +++E     AA++    R  + 
Sbjct: 1215 -DTLDST---NAQQELRSKREQ--------EVTELKKTLEEETRIHEAAVQELRQRHGQA 1262

Query: 805  LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864
            L     G+   +LE   R  G       A++  +    +L+ E+  S   TA  +E   +
Sbjct: 1263 L-----GELAEQLEQARRGKGAWEKTRLALEAEV---SELRAEL--SSLQTAR-QEGEQR 1311

Query: 865  NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924
              R    L       G G     +AA+ + + + + E +    +E  + T +L       
Sbjct: 1312 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL------- 1364

Query: 925  ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQ 984
            + + S   AQL  A   + + T   +A     ++   E   +           R++++ +
Sbjct: 1365 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL-----------REQLEEE 1413

Query: 985  VRVLE-LENELQKERQKLGELRKKHYELAGVAEGWEE 1020
                E    ELQ  + +L E R++  E AG  E  EE
Sbjct: 1414 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEE 1450


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 148/708 (20%), Positives = 281/708 (39%), Gaps = 108/708 (15%)

Query: 378  ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437
            E   RE+  L++  E +  E   +   L+  V++ +A+   Q+  + QAA   E LR + 
Sbjct: 585  EDAQREVQRLRSANELLSREKSNLAHSLQ--VAQQQAEELRQEREKLQAAQ--EELRRQR 640

Query: 438  DELRRQREDT-----------EKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLL 486
            D L  ++ED            E++ R L ++E K     +   +++E  S        L 
Sbjct: 641  DRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ 700

Query: 487  RKNAEVTKQVSMARQAQVDLE-------REKKELEDSLERISDQGQRKTQEQLEVLESLK 539
             + AEV + ++ A   +V+LE        E+  L+DSL ++S   +   Q++L+    L 
Sbjct: 701  AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLD----LN 756

Query: 540  QELATSQRELQVLQGSLETSAQSEANWAAEFAE------LEKE--RDSLVSGAAHREEEL 591
            + +A  + E   LQG  +  A+ EA  A E  E      LE+E  R  L       E+  
Sbjct: 757  RLVAQLEEEKSALQGR-QRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ 815

Query: 592  SALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCA 651
             AL ++L   + + +  +E + QL++      L G  +  EQ  ++A  Q          
Sbjct: 816  EALEQQLPTLRHERSQLQEQLAQLSRQ-----LSGREQELEQARREAQRQ---------- 860

Query: 652  GSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCL 711
                            +E LE++  +  A  ++ +GL  ++ L+A            T L
Sbjct: 861  ----------------VEALERAAREKEALAKEHAGL--AVQLVAAEREGRTLSEEATRL 902

Query: 712  RAPPEPAD-SLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPR 770
            R   E  + SL E  +Q        LA LE       A+  A+   L+K    GE    R
Sbjct: 903  RLEKEALEGSLFEVQRQ--------LAQLEARREQLEAEGQAL--LLAKETLTGELAGLR 952

Query: 771  GLDIKQEELGDLVDKEMAA---------TSAAIETATARIEEMLSKSRAGDTGVKLEVNE 821
               I  +E   L DKE+ A           A++    A  EE L + +        E+  
Sbjct: 953  QQIIATQEKASL-DKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011

Query: 822  RILGCCTSLMQAIQVLIVA----SKDLQREIV------ESGRGTASPKEFYAKNSRWTEG 871
                  + L +  + L+       ++L  EI       + G   A  ++  A + + +E 
Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEK 1071

Query: 872  LISASKAVGWG---ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928
               + K +G     AT+ ++        + + E+     + + +    L A  +  A   
Sbjct: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH 1131

Query: 929  SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988
            +  + +LQ+ +R + +     +      ++Q+   ++          ++R+ +++Q ++ 
Sbjct: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLED------ARDGLRRELLEAQRKLR 1185

Query: 989  ELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEK 1036
            E +   + +RQ+ GELR+   E A   E      E     +++  +E+
Sbjct: 1186 ESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESER 1233



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 112/452 (24%), Positives = 189/452 (41%), Gaps = 60/452 (13%)

Query: 377  IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
            + +L R++SG + +LE  + E+QR V  L+    E EA   E   L  Q        R  
Sbjct: 836  LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 895

Query: 437  LDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQV 496
             +E  R R + E  + SL E++R+    E R  +L+       +  A LL K   +T ++
Sbjct: 896  SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLE------AEGQALLLAKET-LTGEL 948

Query: 497  SMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSL 556
            +  RQ Q+   +EK  L+  L       Q+  Q + E   SL+++ A  + +LQ LQ   
Sbjct: 949  AGLRQ-QIIATQEKASLDKEL-----MAQKLVQAEREAQASLREQRAAHEEDLQRLQ--- 999

Query: 557  ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLA 616
                + EA W     ELE ER  L S     +EEL A R E +  +L   S E +  Q  
Sbjct: 1000 ---REKEAAW----RELEAERAQLQSQLQREQEELLA-RLEAEKEEL---SEEIAALQQE 1048

Query: 617  KDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWS 676
            +D+  +L       AE   Q AL+  E          ++ L+ T  S+++   ++E+   
Sbjct: 1049 RDEGLLL-------AESEKQQALSLKESEK----TALSEKLMGTRHSLATISLEMERQKR 1097

Query: 677  QYLACPEDISGLLHSIT-----LLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRE 731
               +  E     ++++T     L A     A AH          +    L E  +  G++
Sbjct: 1098 DAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA---------QEVRRLQEQARDLGKQ 1148

Query: 732  TLAYLASLEEEGS----LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDK-- 785
              + L   EE  +    LE+A     R  L   + + E     G +++++E G+L     
Sbjct: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRES--QEGREVQRQEAGELRRSLG 1206

Query: 786  EMAATSAAIETATARIEEMLSKSRAGDTGVKL 817
            E A    A+  +   +   + K+ +    +KL
Sbjct: 1207 EGAKEREALRRSNEELRSAVKKAESERISLKL 1238



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 121/613 (19%), Positives = 246/613 (40%), Gaps = 71/613 (11%)

Query: 437  LDELRRQREDTEKAQRSLSE----IERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492
            L  LR+Q  D+E  +R+L E    +  K     Q +   + +   L   +  L R+ + +
Sbjct: 549  LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNL 608

Query: 493  TKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLES---LKQELATSQREL 549
               + +A+Q   +L +E+++L+ + E +  Q  R  +EQ + ++    +++EL  S R+L
Sbjct: 609  AHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQL 668

Query: 550  QVLQG--------------SLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALR 595
            + L+G              +L  +        AE AE+ +      +G    E  ++ LR
Sbjct: 669  EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728

Query: 596  KE---LQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAG 652
             E   LQD+  KL++  ES+ Q   D  +  LV   +  +  +Q    Q E+   ++   
Sbjct: 729  AEEASLQDSLSKLSALNESLAQDKLDLNR--LVAQLEEEKSALQGRQRQAEQEATVAREE 786

Query: 653  SADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLR 712
                            E+LE+   +     + + G L     +A    +A+     T   
Sbjct: 787  Q---------------ERLEELRLEQEVARQGLEGSLR----VAEQAQEALEQQLPTLRH 827

Query: 713  APPEPADSLTEACKQY-GRETLAYLASLEEEGSLENADSTAM-RNCLSKIKA-IGEELLP 769
               +  + L +  +Q  GRE     A  E +  +E  +  A  +  L+K  A +  +L+ 
Sbjct: 828  ERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVA 887

Query: 770  ---RGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILG- 825
                G  + +E     ++KE      A+E +   ++  L++  A    ++ E    +L  
Sbjct: 888  AEREGRTLSEEATRLRLEKE------ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK 941

Query: 826  -CCTSLMQAIQVLIVASKD--------LQREIVESGR-GTASPKEFYAKNSRWTEGLISA 875
               T  +  ++  I+A+++        + +++V++ R   AS +E  A +    + L   
Sbjct: 942  ETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRL-QR 1000

Query: 876  SKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQL 935
             K   W   +  + A L  Q + + EEL+          ++ +AA + + D+        
Sbjct: 1001 EKEAAW-RELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESE 1059

Query: 936  QQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQ 995
            +Q +  + ++    ++  + G      T +++          RQE D    V  L +EL+
Sbjct: 1060 KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST-VNALTSELR 1118

Query: 996  KERQKLGELRKKH 1008
              R +  E    H
Sbjct: 1119 DLRAQREEAAAAH 1131



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 58/268 (21%), Positives = 104/268 (38%), Gaps = 14/268 (5%)

Query: 378  ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437
            + L  + S L  QL  M+ E      + +    +L+  +AE +  R+        ++AEL
Sbjct: 1526 DELRTQTSALNRQLAEMEAERDSATSRAR----QLQKAVAESEEARRSVDGRLSGVQAEL 1581

Query: 438  ----DELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493
                + +RR   +       ++ +ER  QA E      +EK S++  N   L      + 
Sbjct: 1582 ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLK 1641

Query: 494  KQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQ 553
            + +  +    V LE +++ LE  L+R S  G    + Q + L+     L     + +V  
Sbjct: 1642 EVLDASESRTVKLELQRRSLEGELQR-SRLGLSDREAQAQALQDRVDSLQRQVADSEVKA 1700

Query: 554  GSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMC 613
            G+L+ + +      A+  E E      V G      + SA     +D  L L        
Sbjct: 1701 GTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHL-----QKA 1755

Query: 614  QLAKDQRKMLLVGSRKAAEQVIQDALNQ 641
              A +  + +L     AA Q + +A  Q
Sbjct: 1756 LTACEHDRQVLQERLDAARQALSEARKQ 1783



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 139/678 (20%), Positives = 249/678 (36%), Gaps = 92/678 (13%)

Query: 382  REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
            RE   L+ QL  ++         L+  + E +  L E Q  R+    +   LR  L E  
Sbjct: 1154 REAEELRTQLRLLEDARDG----LRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGA 1209

Query: 442  RQREDTEKAQRSLSEIERKAQAN-----------EQRYSKLKEKYSELVQNHADLLRKNA 490
            ++RE   ++   L    +KA++            EQ+ + L+E  + + +   +L     
Sbjct: 1210 KEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ 1269

Query: 491  EVTKQVSMARQAQVDLEREKKELEDSLERISDQ----------GQRKTQEQLE------- 533
            EV +    AR+   +L R+ K L+    R+  +          G+R  +E          
Sbjct: 1270 EVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQ 1329

Query: 534  -------VLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAH 586
                    LE ++QEL  +QR+LQ  +G   T  +       E    EK++   +  A  
Sbjct: 1330 RLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQ---LDHARG 1386

Query: 587  REEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
             E +L A R E  +  L+L++ E     L  +  ++ +   R+AAE  +    + L    
Sbjct: 1387 LELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEV--QRRAAEAQLGGLRSALRRG- 1443

Query: 647  LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706
                       L    + S     +  S ++         GL    TL     S   + G
Sbjct: 1444 -----------LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492

Query: 707  ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
              T     P   D   EA +   RE L  L S + E       ++A+   L++++A  + 
Sbjct: 1493 PAT----SPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDS 1548

Query: 767  LLPRGLDIKQ-----EELGDLVDKEMAATSA--AIETATARIEEMLSKSRAGDTGV---K 816
               R   +++     EE    VD  ++   A  A++  + R  E   ++           
Sbjct: 1549 ATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERS 1608

Query: 817  LEVNERILGCC---TSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLI 873
            L+  E  L       S M+A +  +   K   +E++++        E      R  EG +
Sbjct: 1609 LQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLEL---QRRSLEGEL 1665

Query: 874  SASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLA 933
              S+ +G       +A    +Q R    +  V   E+ A T QL        ++ +  LA
Sbjct: 1666 QRSR-LGLSDR---EAQAQALQDRVDSLQRQVADSEVKAGTLQLT------VERLNGALA 1715

Query: 934  QLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENE 993
            +++++   +     G+  +     + +  T   D +      +   E D QV    L+  
Sbjct: 1716 KVEESEGALRDKVRGLTEALAQSSASLNST--RDKNLHLQKALTACEHDRQV----LQER 1769

Query: 994  LQKERQKLGELRKKHYEL 1011
            L   RQ L E RK+   L
Sbjct: 1770 LDAARQALSEARKQSSSL 1787



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 60/288 (20%), Positives = 124/288 (43%), Gaps = 22/288 (7%)

Query: 378  ERLYREISGLKAQLEN-MKTESQRVVLQLKGHVSELEADLAEQQHLRQQA-----ADDCE 431
            E  +RE+   +AQL++ ++ E + ++ +L+    EL  ++A  Q  R +      ++  +
Sbjct: 1003 EAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQ 1062

Query: 432  FLRAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
             L  +  E     E     + SL+    E+ER+ +  + R  + +   + L     DL  
Sbjct: 1063 ALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA 1122

Query: 488  KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
            +  E     +   +   +  R+  +  DS  R +++ + + +   +  + L++EL  +QR
Sbjct: 1123 QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182

Query: 548  ELQVLQGSLETSAQSEANWAAEFAELEKERDS-------LVSGAAHREEELSALRKELQD 600
            +L+  Q   E   Q          E  KER++       L S     E E  +L+   +D
Sbjct: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1242

Query: 601  TQLKLASTEESMCQLAKDQRKML-----LVGSRKAAEQVIQDALNQLE 643
             + KLA  EE+   + K+  ++      +  SR  A + +Q+   Q++
Sbjct: 1243 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 56/276 (20%), Positives = 125/276 (45%), Gaps = 26/276 (9%)

Query: 372  EKDHLIERLYREISGLKAQLENMKTES---QRVVLQLKGHVSELEADLAEQQHLRQQAAD 428
            +++   + L   +  L+ Q+ + + ++   Q  V +L G ++++E     +  LR +   
Sbjct: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES---EGALRDKVRG 1730

Query: 429  DCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRK 488
              E L      L   R+     Q++L+  E   Q  ++R    ++  SE         ++
Sbjct: 1731 LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA-------RKQ 1783

Query: 489  NAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRE 548
            ++ + +QV   R    DLE ++ E E  L+++ +  +++ + +   L ++ Q+L   +R 
Sbjct: 1784 SSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTV-QKLQDERRL 1842

Query: 549  LQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAST 608
            LQ   GSL+ +           A+LE E+  +   A   E++  ALR+ L   + +   +
Sbjct: 1843 LQERLGSLQRA----------LAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS 1892

Query: 609  EESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
             E   +L+ ++ +  L  +   AE  + +A  Q+++
Sbjct: 1893 HEDTVRLSAEKGR--LDRTLTGAELELAEAQRQIQQ 1926



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 50/217 (23%), Positives = 96/217 (44%), Gaps = 22/217 (10%)

Query: 397  ESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSE 456
            E  R VLQ +  +      L+E +       +  + LR E+ +L  QR + E   + L E
Sbjct: 1760 EHDRQVLQER--LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLRE 1817

Query: 457  IERKAQANE----QRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKE 512
            + R+ Q  E        KL+++   L +    L R  A++  +     ++ + LE+++  
Sbjct: 1818 VLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVA 1877

Query: 513  LEDSLERISDQGQRKTQEQLEV----------LESLKQELATSQRELQVLQGSL------ 556
            L  +L+++  +  R  ++ + +          L   + ELA +QR++Q L+  +      
Sbjct: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQS 1937

Query: 557  ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593
             + AQ E +   +  EL++E + L S  A  E  L A
Sbjct: 1938 HSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEA 1974



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 68/308 (22%), Positives = 121/308 (39%), Gaps = 47/308 (15%)

Query: 372  EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSE--LEADLAEQQHLRQQAAD- 428
            E+  L  +L RE   L A+LE  K E    +  L+    E  L A+  +QQ L  + ++ 
Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEK 1071

Query: 429  -----------------DCEFLRAELDELRRQREDTEKAQRSLSEI-------ERKAQAN 464
                               E  R + D   RQ +D        SE+       E  A A+
Sbjct: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH 1131

Query: 465  EQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQG 524
             Q   +L+E+  +L +     LR+  E+  Q+ +   A+  L RE  E +  L    +  
Sbjct: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR 1191

Query: 525  QRKTQEQLEVLESL-------------KQELATSQRELQVLQGSLETSAQSEANWAAEFA 571
            + + QE  E+  SL              +EL ++ ++ +  + SL+ + + +    A   
Sbjct: 1192 EVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLE 1251

Query: 572  ELE----KERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM---LL 624
            E      KE   L +G    E      R+ELQ+ + ++   +    +L ++  ++   L 
Sbjct: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311

Query: 625  VGSRKAAE 632
            +G R   E
Sbjct: 1312 LGERAEKE 1319



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 48/193 (24%), Positives = 91/193 (47%), Gaps = 20/193 (10%)

Query: 376  LIERLYREISGLKAQLENM-KTESQRVVLQ-----LKGHVSELEADLAEQQHLRQQAADD 429
            L E L +   G  A L  + K + +R +LQ     L+  +++LEA+  E +    +   D
Sbjct: 1815 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKD 1874

Query: 430  CEFLRAELDELRRQR----EDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485
               LR  LD++ R++    EDT +       ++R     E    +L E   ++ Q  A +
Sbjct: 1875 RVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAEL---ELAEAQRQIQQLEAQV 1931

Query: 486  LRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE-SLKQELAT 544
            +     V +Q     Q +VD ++++ EL+  +ER+    Q +T+  LE  E + +Q +  
Sbjct: 1932 V-----VLEQSHSPAQLEVDAQQQQLELQQEVERLR-SAQAQTERTLEARERAHRQRVRG 1985

Query: 545  SQRELQVLQGSLE 557
             + ++  L+G L+
Sbjct: 1986 LEEQVSTLKGQLQ 1998



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 160/795 (20%), Positives = 298/795 (37%), Gaps = 162/795 (20%)

Query: 380  LYREISGLKAQLENMKTESQRVVLQLKGHVSEL-----EADLAEQQHLR------QQAAD 428
            L+R++ G +  +  +K  ++R +LQL G ++       EA L     LR      + A +
Sbjct: 299  LWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALE 358

Query: 429  DCEFLRAELDELRRQREDTEK--AQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLL 486
                L+A+L+E  R +   EK  AQ+ +     KA  +  R ++L      L + + +  
Sbjct: 359  KQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLS-ARVTELGLAVKRLEKQNLEKD 417

Query: 487  RKNAEVTKQV----SMARQAQVDLEREKKE-LEDSLERISDQGQRKTQEQLEVLESLKQE 541
            + N ++T+++    S+  Q Q  LE E  E L+ +L  ++ Q      E    L   ++ 
Sbjct: 418  QVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLA-QAVLSDSESGVQLSGSERT 476

Query: 542  LATSQRELQVLQGSLETS-------------------AQSEANWAAEFAELEKERDSLVS 582
               S   L+ L G    S                   A S+++  A       +R   V 
Sbjct: 477  ADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQ 536

Query: 583  GAAHREEE----LSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638
                R E     L  LRK+L D++ +  + EE + Q  +D+      G+ +A E   ++ 
Sbjct: 537  DMRGRYEASQDLLGTLRKQLSDSESERRALEEQL-QRLRDKTD----GAMQAHEDAQREV 591

Query: 639  LNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698
                    L+S   S  +L  ++       E+L +   +  A  E+   L      L   
Sbjct: 592  QRLRSANELLSREKS--NLAHSLQVAQQQAEELRQEREKLQAAQEE---LRRQRDRLEEE 646

Query: 699  TSDAIAHGA--------------------TTCLRAPPEPADSLTEACKQYG-----RETL 733
              DA+  GA                    +   +   E  ++L+ A  Q       +  +
Sbjct: 647  QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706

Query: 734  AYLASLEEEGSLE--------NADSTAMRNCLSKIKAIGEELLPRGLDIK------QEEL 779
            A   +  E G +E         A+  ++++ LSK+ A+ E L    LD+       +EE 
Sbjct: 707  AEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEK 766

Query: 780  GDLVDKEMAATSAA--IETATARIEEMLSKSRAGDTGV---------------------- 815
              L  ++  A   A        R+EE+  +      G+                      
Sbjct: 767  SALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLR 826

Query: 816  --KLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK-NSRWTEGL 872
              + ++ E++      L    Q L  A ++ QR+ VE+    A  KE  AK ++     L
Sbjct: 827  HERSQLQEQLAQLSRQLSGREQELEQARREAQRQ-VEALERAAREKEALAKEHAGLAVQL 885

Query: 873  ISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIA--------------------- 911
            ++A +    G T+  +A  L ++       L     ++A                     
Sbjct: 886  VAAERE---GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942

Query: 912  ------ASTAQLVAASKVKADKDSPNLAQ-LQQASRGVNQATAGVVASTISGKSQIEETD 964
                  A   Q + A++ KA  D   +AQ L QA R   +A A +     + +  ++   
Sbjct: 943  TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER---EAQASLREQRAAHEEDLQRLQ 999

Query: 965  NMDFSSMTLTQIKRQEMDSQVR--VLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022
                ++    + +R ++ SQ++    EL   L+ E+++L E      E+A + +  +EG 
Sbjct: 1000 REKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSE------EIAALQQERDEGL 1053

Query: 1023 EASPPTLQEVVTEKE 1037
              +    Q+ ++ KE
Sbjct: 1054 LLAESEKQQALSLKE 1068



 Score = 38.5 bits (88), Expect = 0.033
 Identities = 45/188 (23%), Positives = 86/188 (45%), Gaps = 18/188 (9%)

Query: 372 EKDHLIERLYREISGLKAQLENMKTE--------SQRVVLQLKGHVSELEADLAEQQHLR 423
           E++ L+++    +  L AQ    + E        S+R+   L+    ELE    E + L 
Sbjct: 81  EENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQ--EPRGLV 138

Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
           +Q+ +    L+ E    RR+ +  ++ Q+  +++ ++ Q    +Y   K++ SEL Q   
Sbjct: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQY---KKRCSELEQQ-- 193

Query: 484 DLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ--RKTQEQLEVLESLKQE 541
            LL ++ E+ +Q     +   DLE     LE+  +R +   Q     +EQL+   S  Q 
Sbjct: 194 -LLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQA 252

Query: 542 LATSQREL 549
           L+   R++
Sbjct: 253 LSEDIRKV 260



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 31/108 (28%), Positives = 54/108 (50%), Gaps = 16/108 (14%)

Query: 383  EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442
            E+   +AQ +  + E+Q VVL+     ++LE D A+QQ L          L+ E++ LR 
Sbjct: 1914 ELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVD-AQQQQLE---------LQQEVERLRS 1963

Query: 443  QREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
             +  TE+       +E + +A+ QR   L+E+ S L       LR+++
Sbjct: 1964 AQAQTERT------LEARERAHRQRVRGLEEQVSTLKGQLQQELRRSS 2005


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 85/341 (24%), Positives = 146/341 (42%), Gaps = 56/341 (16%)

Query: 378  ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437
            E+L RE   L A+  ++K + +   + + G   ++ +  AE Q +  Q + D     A L
Sbjct: 1482 EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD----EASL 1537

Query: 438  DELRRQREDTE-KAQRSLSEIERKA---QANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493
             ++++Q  D E K +    E++ +A   Q  EQ   +L+ +   + Q H+  +    E  
Sbjct: 1538 AKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV 1597

Query: 494  KQVSMA-----RQAQVDLE----------REKKELEDSLERISDQGQRKTQEQLE----- 533
            ++   +     +Q +V LE          REK+ELE  L  +SDQ  R+  E  +     
Sbjct: 1598 EEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKD 1657

Query: 534  -------------VLESLKQELATSQRELQVLQGSLETS-------AQSEANWAAEFAEL 573
                         +L+ LK   A S+RE+  L+  LE S        ++      E  +L
Sbjct: 1658 LKRTKALLADAQLMLDHLKNS-APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716

Query: 574  EKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
              + D +       EE+LS L++E  + Q +L   +E M +L K  +  +   SR  A+ 
Sbjct: 1717 HLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ- 1775

Query: 634  VIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKS 674
             I D   QLEE            L   + ++ S +E LE+S
Sbjct: 1776 -INDLQAQLEE-----ANKEKQELQEKLQALQSQVEFLEQS 1810



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 61/283 (21%), Positives = 134/283 (47%), Gaps = 17/283 (6%)

Query: 361  NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTE--SQRVVLQLKGHVSELEADLAE 418
            +F S+  + KD     ++R    ++  +  L+++K    S+R + QLK  + E E   A 
Sbjct: 1647 DFESEKRLRKD-----LKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAA 1701

Query: 419  QQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSEL 478
                R+    + E L  ++D++ + +   E+    LS ++R+    + R  + +E  +EL
Sbjct: 1702 AVKARKAMEVEIEDLHLQIDDIAKAKTALEE---QLSRLQREKNEIQNRLEEDQEDMNEL 1758

Query: 479  VQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538
            ++ H   + + +    Q++  +    +  +EK+EL++ L+ +  Q Q +  EQ  V +SL
Sbjct: 1759 MKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL--QSQVEFLEQSMVDKSL 1816

Query: 539  KQELATSQRELQVLQGSLETSAQSEANWAAEFAE----LEKERDSLVSGAAHREEELSAL 594
                    REL+       T  +   + A+   E    L +ERD  ++     +E+   L
Sbjct: 1817 VSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRL 1876

Query: 595  RKELQDTQLKLASTEESMCQLAKDQRKMLL-VGSRKAAEQVIQ 636
            +++L+DT+ ++        + ++ + ++ + + S +AA Q +Q
Sbjct: 1877 QRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 67/261 (25%), Positives = 116/261 (44%), Gaps = 25/261 (9%)

Query: 378  ERLYREISGLKAQL----ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL 433
            ER  RE+   K +L    E+     Q+   QL+  + +L+AD  E Q   QQ    C+ L
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRL 1435

Query: 434  RAELDELRRQRE-------DTEKAQR----SLSEIERKAQANEQRYSKLKEKYSELVQNH 482
             AEL + +   E       + EK QR     LS+   +AQ  + +  KL+ +   L+   
Sbjct: 1436 TAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEA 1495

Query: 483  ADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQEL 542
              L ++  E    ++   Q  V LE E +++  S E   +    K ++QL  LE+   ++
Sbjct: 1496 FSLKQQLEEKDMDIAGFTQKVVSLEAELQDI-SSQESKDEASLAKVKKQLRDLEA---KV 1551

Query: 543  ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ 602
               + EL    G+++   Q++        E+E+ R +       R+EE+   R   Q  Q
Sbjct: 1552 KDQEEELDEQAGTIQMLEQAKLRLE---MEMERMRQTHSKEMESRDEEVEEAR---QSCQ 1605

Query: 603  LKLASTEESMCQLAKDQRKML 623
             KL   E  + +  +D++K+L
Sbjct: 1606 KKLKQMEVQLEEEYEDKQKVL 1626



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 54/235 (22%), Positives = 107/235 (45%), Gaps = 20/235 (8%)

Query: 383  EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442
            +I+  K  LE   +  QR   +++  + E + D+ E     + A        A++++L+ 
Sbjct: 1722 DIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQA 1781

Query: 443  QREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQA 502
            Q E+  K ++ L E   K QA       L+ +   L Q+  D     + V++Q +  R+ 
Sbjct: 1782 QLEEANKEKQELQE---KLQA-------LQSQVEFLEQSMVD----KSLVSRQEAKIREL 1827

Query: 503  QVDLEREK---KELEDSLERISDQGQRKTQEQLEVLESLKQELATS---QRELQVLQGSL 556
            +  LE E+   K LE    R+ +  ++ T+E+ + + +  +E   +   QR+L+  +  +
Sbjct: 1828 ETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEM 1887

Query: 557  ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEES 611
               A+ EA  + +  ELE + +SL +     + +L    K + D Q  +    ES
Sbjct: 1888 GELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMES 1942



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 135/695 (19%), Positives = 253/695 (36%), Gaps = 124/695 (17%)

Query: 431  EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
            E +R + +E+++ R   EKA++  +E+   +   E R S+L    SEL        R   
Sbjct: 1254 EQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELT---SELTDE-----RNTG 1305

Query: 491  EVTKQVSMARQAQ-VDLEREKKELEDSLERISDQGQRKTQEQLEVLES------------ 537
            E   Q+  A  A+ +  E+E KEL+   + +  Q +     ++EV+E+            
Sbjct: 1306 ESASQLLDAETAERLRAEKEMKELQTQYDALKKQME---VMEMEVMEARLIRAAEINGEV 1362

Query: 538  ----------LKQELA------TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLV 581
                      LK E A      T +R  Q  +  LE   Q++        +L+ + +   
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQ 1422

Query: 582  SGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM---LLVGSRKAAEQVIQDA 638
                  +++   L  ELQDT+L L   +    +L K QR+    L     +A  + +Q  
Sbjct: 1423 RALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQRE 1482

Query: 639  LNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698
              Q E+          D LL+   S+   +E+ +   + +      +   L  I+     
Sbjct: 1483 KLQREK----------DMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532

Query: 699  TSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADST------- 751
               ++A           +  D   E  +Q G   +   A L  E  +E    T       
Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMES 1592

Query: 752  -------AMRNCLSKIKAIGEEL------------LPRGLDIKQEELGDLVD-------- 784
                   A ++C  K+K +  +L              R L+ K   L D V+        
Sbjct: 1593 RDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEK 1652

Query: 785  ---KEMAATSAAIETATARIEEML----SKSRAGDTGVKLEVNERILGCCTSLMQAIQVL 837
               K++  T A +  A   ++ +     SK        +LE +E     C + ++A + +
Sbjct: 1653 RLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESE---FTCAAAVKARKAM 1709

Query: 838  IVASKDLQREIVESGRGTASPKEFYAKNSR---------------WTEGLISASKAVGWG 882
             V  +DL  +I +  +   + +E  ++  R                 E +     AV   
Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1769

Query: 883  ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGV 942
            +  +    DL  Q     +E      ++ A  +Q+    +   DK   +L   Q+A   +
Sbjct: 1770 SRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDK---SLVSRQEAK--I 1824

Query: 943  NQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLE----LENELQKER 998
             +    +       K        +  +   LT+ + Q + ++ R  E    L+ +L+  +
Sbjct: 1825 RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1884

Query: 999  QKLGELRKKHYELAGVAEGWE---EGTEASPPTLQ 1030
            +++GEL +K  E +      E   E  EA+  +LQ
Sbjct: 1885 EEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 85/341 (24%), Positives = 146/341 (42%), Gaps = 56/341 (16%)

Query: 378  ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437
            E+L RE   L A+  ++K + +   + + G   ++ +  AE Q +  Q + D     A L
Sbjct: 1482 EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD----EASL 1537

Query: 438  DELRRQREDTE-KAQRSLSEIERKA---QANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493
             ++++Q  D E K +    E++ +A   Q  EQ   +L+ +   + Q H+  +    E  
Sbjct: 1538 AKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV 1597

Query: 494  KQVSMA-----RQAQVDLE----------REKKELEDSLERISDQGQRKTQEQLE----- 533
            ++   +     +Q +V LE          REK+ELE  L  +SDQ  R+  E  +     
Sbjct: 1598 EEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKD 1657

Query: 534  -------------VLESLKQELATSQRELQVLQGSLETS-------AQSEANWAAEFAEL 573
                         +L+ LK   A S+RE+  L+  LE S        ++      E  +L
Sbjct: 1658 LKRTKALLADAQLMLDHLKNS-APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716

Query: 574  EKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
              + D +       EE+LS L++E  + Q +L   +E M +L K  +  +   SR  A+ 
Sbjct: 1717 HLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ- 1775

Query: 634  VIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKS 674
             I D   QLEE            L   + ++ S +E LE+S
Sbjct: 1776 -INDLQAQLEE-----ANKEKQELQEKLQALQSQVEFLEQS 1810



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 61/283 (21%), Positives = 134/283 (47%), Gaps = 17/283 (6%)

Query: 361  NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTE--SQRVVLQLKGHVSELEADLAE 418
            +F S+  + KD     ++R    ++  +  L+++K    S+R + QLK  + E E   A 
Sbjct: 1647 DFESEKRLRKD-----LKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAA 1701

Query: 419  QQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSEL 478
                R+    + E L  ++D++ + +   E+    LS ++R+    + R  + +E  +EL
Sbjct: 1702 AVKARKAMEVEIEDLHLQIDDIAKAKTALEE---QLSRLQREKNEIQNRLEEDQEDMNEL 1758

Query: 479  VQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538
            ++ H   + + +    Q++  +    +  +EK+EL++ L+ +  Q Q +  EQ  V +SL
Sbjct: 1759 MKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL--QSQVEFLEQSMVDKSL 1816

Query: 539  KQELATSQRELQVLQGSLETSAQSEANWAAEFAE----LEKERDSLVSGAAHREEELSAL 594
                    REL+       T  +   + A+   E    L +ERD  ++     +E+   L
Sbjct: 1817 VSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRL 1876

Query: 595  RKELQDTQLKLASTEESMCQLAKDQRKMLL-VGSRKAAEQVIQ 636
            +++L+DT+ ++        + ++ + ++ + + S +AA Q +Q
Sbjct: 1877 QRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 67/261 (25%), Positives = 116/261 (44%), Gaps = 25/261 (9%)

Query: 378  ERLYREISGLKAQL----ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL 433
            ER  RE+   K +L    E+     Q+   QL+  + +L+AD  E Q   QQ    C+ L
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRL 1435

Query: 434  RAELDELRRQRE-------DTEKAQR----SLSEIERKAQANEQRYSKLKEKYSELVQNH 482
             AEL + +   E       + EK QR     LS+   +AQ  + +  KL+ +   L+   
Sbjct: 1436 TAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEA 1495

Query: 483  ADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQEL 542
              L ++  E    ++   Q  V LE E +++  S E   +    K ++QL  LE+   ++
Sbjct: 1496 FSLKQQLEEKDMDIAGFTQKVVSLEAELQDI-SSQESKDEASLAKVKKQLRDLEA---KV 1551

Query: 543  ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ 602
               + EL    G+++   Q++        E+E+ R +       R+EE+   R   Q  Q
Sbjct: 1552 KDQEEELDEQAGTIQMLEQAKLRLE---MEMERMRQTHSKEMESRDEEVEEAR---QSCQ 1605

Query: 603  LKLASTEESMCQLAKDQRKML 623
             KL   E  + +  +D++K+L
Sbjct: 1606 KKLKQMEVQLEEEYEDKQKVL 1626



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 54/235 (22%), Positives = 107/235 (45%), Gaps = 20/235 (8%)

Query: 383  EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442
            +I+  K  LE   +  QR   +++  + E + D+ E     + A        A++++L+ 
Sbjct: 1722 DIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQA 1781

Query: 443  QREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQA 502
            Q E+  K ++ L E   K QA       L+ +   L Q+  D     + V++Q +  R+ 
Sbjct: 1782 QLEEANKEKQELQE---KLQA-------LQSQVEFLEQSMVD----KSLVSRQEAKIREL 1827

Query: 503  QVDLEREK---KELEDSLERISDQGQRKTQEQLEVLESLKQELATS---QRELQVLQGSL 556
            +  LE E+   K LE    R+ +  ++ T+E+ + + +  +E   +   QR+L+  +  +
Sbjct: 1828 ETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEM 1887

Query: 557  ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEES 611
               A+ EA  + +  ELE + +SL +     + +L    K + D Q  +    ES
Sbjct: 1888 GELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMES 1942



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 135/695 (19%), Positives = 253/695 (36%), Gaps = 124/695 (17%)

Query: 431  EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
            E +R + +E+++ R   EKA++  +E+   +   E R S+L    SEL        R   
Sbjct: 1254 EQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELT---SELTDE-----RNTG 1305

Query: 491  EVTKQVSMARQAQ-VDLEREKKELEDSLERISDQGQRKTQEQLEVLES------------ 537
            E   Q+  A  A+ +  E+E KEL+   + +  Q +     ++EV+E+            
Sbjct: 1306 ESASQLLDAETAERLRAEKEMKELQTQYDALKKQME---VMEMEVMEARLIRAAEINGEV 1362

Query: 538  ----------LKQELA------TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLV 581
                      LK E A      T +R  Q  +  LE   Q++        +L+ + +   
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQ 1422

Query: 582  SGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM---LLVGSRKAAEQVIQDA 638
                  +++   L  ELQDT+L L   +    +L K QR+    L     +A  + +Q  
Sbjct: 1423 RALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQRE 1482

Query: 639  LNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698
              Q E+          D LL+   S+   +E+ +   + +      +   L  I+     
Sbjct: 1483 KLQREK----------DMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532

Query: 699  TSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADST------- 751
               ++A           +  D   E  +Q G   +   A L  E  +E    T       
Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMES 1592

Query: 752  -------AMRNCLSKIKAIGEEL------------LPRGLDIKQEELGDLVD-------- 784
                   A ++C  K+K +  +L              R L+ K   L D V+        
Sbjct: 1593 RDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEK 1652

Query: 785  ---KEMAATSAAIETATARIEEML----SKSRAGDTGVKLEVNERILGCCTSLMQAIQVL 837
               K++  T A +  A   ++ +     SK        +LE +E     C + ++A + +
Sbjct: 1653 RLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESE---FTCAAAVKARKAM 1709

Query: 838  IVASKDLQREIVESGRGTASPKEFYAKNSR---------------WTEGLISASKAVGWG 882
             V  +DL  +I +  +   + +E  ++  R                 E +     AV   
Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1769

Query: 883  ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGV 942
            +  +    DL  Q     +E      ++ A  +Q+    +   DK   +L   Q+A   +
Sbjct: 1770 SRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDK---SLVSRQEAK--I 1824

Query: 943  NQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLE----LENELQKER 998
             +    +       K        +  +   LT+ + Q + ++ R  E    L+ +L+  +
Sbjct: 1825 RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1884

Query: 999  QKLGELRKKHYELAGVAEGWE---EGTEASPPTLQ 1030
            +++GEL +K  E +      E   E  EA+  +LQ
Sbjct: 1885 EEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 140/651 (21%), Positives = 262/651 (40%), Gaps = 86/651 (13%)

Query: 373  KDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEF 432
            KD+ +  L ++++ L++QL+ ++ E   +  +LK   +E+ +  + +Q  +QQ A   E 
Sbjct: 529  KDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEA 588

Query: 433  ---LRAELDELR--RQREDTEKAQRSLSEIERKAQANEQRYSKLKEK---YSELVQNHAD 484
               L+ E+  ++  +  +        L  +    Q  E ++  +KEK    ++L    AD
Sbjct: 589  RVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEAD 648

Query: 485  LLRKNAEVTKQVSMARQAQVDLEREKKELE---DSLERISDQGQRKTQEQLEV------- 534
            +L + A   +        + DL+R  +E E   + L+R++D      Q+  +V       
Sbjct: 649  MLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQR 708

Query: 535  ---LESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEEL 591
               LE+L+QE     ++L + Q +L++  QS       + EL+     L   AA RE+ +
Sbjct: 709  DQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI 768

Query: 592  SALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAE--QVIQDALNQLEEPPLIS 649
              L+ E            E+  Q AK  ++ L  G+R+  E  +   + L +L E   I 
Sbjct: 769  CLLQNE--------KIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIK 820

Query: 650  CAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATT 709
             +G  +HL     ++    +Q++K   Q+L     +       T    L S+        
Sbjct: 821  -SGQVEHLQQETAALK---KQMQKIKEQFLQQKVMVEAYRRDATSKDQLISE-------- 868

Query: 710  CLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLP 769
             L+A  +  DS  +  +Q   +      + E E S  + +   +R  ++ ++   +    
Sbjct: 869  -LKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQK 927

Query: 770  RGLDIKQEELGDLVDKE-MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCT 828
               +++        DKE M A + A E    +IEE+  ++R   T  K ++  R LG   
Sbjct: 928  ERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKM--RRLG--- 982

Query: 829  SLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTE--GLISASKAVGWGATVM 886
                          DL          T++ KE   K+  +    G++S        A   
Sbjct: 983  -------------SDL----------TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEA 1019

Query: 887  VDAADLVVQGRGKFEELMVCSHE-IAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQA 945
             DA    ++ +G   +  +  HE I A  A+L A S  K   +      +   S+ + + 
Sbjct: 1020 ADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEE- 1078

Query: 946  TAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQK 996
                     S +  +E  D +  S     +IKR E  ++   LELE+E  K
Sbjct: 1079 ---------SREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGK 1120



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 140/630 (22%), Positives = 233/630 (36%), Gaps = 88/630 (13%)

Query: 296 PNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSF 355
           P+  + S      S   V+   + SPD++  LE   L     S+ +  D+     + S+ 
Sbjct: 266 PDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSDSSS-YSSAS 324

Query: 356 SSDPFNFNSQNGVNKDEK-----DHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVS 410
           +   +   S+    +D         +      +   +K  L+    E Q    ++ G V 
Sbjct: 325 TRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVR 384

Query: 411 E----------LEADLAEQQHLRQQAADDCEFLRAELDELRRQREDT--EKA--QRSLSE 456
                      LE+  AE Q    Q   +   L  +L+ L  +      EKA  Q  L+ 
Sbjct: 385 SRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAA 444

Query: 457 IERKAQA-------NEQRYSKLKEKYSELVQNHADLLR-----KNAEVTKQVSMARQAQV 504
           +  K QA       ++QR   L  +   L Q+  DL R     +N    K  S+A  +  
Sbjct: 445 LSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLA-SSNN 503

Query: 505 DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEA 564
           DL+  +++ +  + ++ D  QR    +   +  L+Q++   Q +LQ +Q    T      
Sbjct: 504 DLQVAEEQYQRLMAKVEDM-QRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLK 562

Query: 565 NWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ------------LKLASTEESM 612
              AE + L+  R       A  +E    L+ E+   Q            LKL +   S 
Sbjct: 563 ASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQ 622

Query: 613 CQLAKDQRKMLLVGSRKAAE---------------QVIQDALNQLEEP---PLISCAGSA 654
            QL + Q + +    R AA+                 IQ+A   +EE     L    G  
Sbjct: 623 -QLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGER 681

Query: 655 DHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHS-ITLLAHLTSDAIAHGATTCLRA 713
           + L     S +S  +QLE+     L   + +  L    + L+  LT    A      L++
Sbjct: 682 ERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEA------LQS 735

Query: 714 PPEPADSL----TEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLP 769
             +  D+L     E   + G E     AS E+   L   +   +   L   K+ G+E L 
Sbjct: 736 REQSLDALQTHYDELQARLG-ELQGEAASREDTICLLQNEKIILEAALQAAKS-GKEELD 793

Query: 770 RG---LDIKQEELGDLVDK---EMAATSAAIE---TATARIEEMLSKSRAGDTGVKLEVN 820
           RG   L+   EE  + ++K   E+A  S  +E     TA +++ + K +      K+ V 
Sbjct: 794 RGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMV- 852

Query: 821 ERILGCCTSLMQAIQVLIVASKDLQREIVE 850
           E      TS  Q I  L    K L  E+ E
Sbjct: 853 EAYRRDATSKDQLISELKATRKRLDSELKE 882



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 63/284 (22%), Positives = 126/284 (44%), Gaps = 38/284 (13%)

Query: 364  SQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQL---KGHVSEL-EADLAEQ 419
            SQ      EK   +E   +E  G + +++ ++  ++++ L+L   KG ++ L +++ A +
Sbjct: 1073 SQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALR 1132

Query: 420  QH-------LRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLK 472
            +H       L ++ AD  + L  ++  + +++E+ ++  + L       QA +    K K
Sbjct: 1133 EHNSILETALAKREADLVQ-LNLQVQAVLQRKEEEDRQMKHL------VQALQASLEKEK 1185

Query: 473  EKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELE------DSLERISDQGQR 526
            EK + L +  A       E        + A ++L   KKEL+        L+  +D  Q 
Sbjct: 1186 EKVNSLKEQVA---AAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI 1242

Query: 527  KTQEQLEVLESLKQELATSQRELQVLQGSLE-------TSAQSEANWAAEFAELEKERDS 579
            +  +  + +   + ELA ++ +LQ+LQ  L+          Q   N   E  + E+E  S
Sbjct: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302

Query: 580  LVSGAAHREE----ELSALRKELQDTQLKLASTEESMCQLAKDQ 619
            L       E+    EL  L++ LQ+ + +L   +E +    KD+
Sbjct: 1303 LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDK 1346



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 56/273 (20%), Positives = 118/273 (43%), Gaps = 36/273 (13%)

Query: 380  LYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439
            L+  I  L+A+L+ +      +  +L+  ++    +L E +    +  D+ +  R    +
Sbjct: 1040 LHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKK 1099

Query: 440  LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS----ELVQNHADLLRKNAEVTKQ 495
            ++R  E  +K    L   + K     Q  + L+E  S     L +  ADL++ N +V  Q
Sbjct: 1100 IKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQV--Q 1157

Query: 496  VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555
              + R+ + D  R+ K L  +L       Q   +++ E + SLK+++A ++ E       
Sbjct: 1158 AVLQRKEEED--RQMKHLVQAL-------QASLEKEKEKVNSLKEQVAAAKVE------- 1201

Query: 556  LETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQL 615
               +  +  ++ A   EL + +  L +    +E  +  L+ E  D Q++     + + Q 
Sbjct: 1202 ---AGHNRRHFKAASLELSEVKKELQA----KEHLVQKLQAEADDLQIREGKHSQEIAQF 1254

Query: 616  AKDQRKMLLVGSRKAAEQVIQDALN-QLEEPPL 647
              +      +   +A  Q++Q  L+ QL + P+
Sbjct: 1255 QAE------LAEARAQLQLLQKQLDEQLSKQPV 1281


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 126/672 (18%), Positives = 259/672 (38%), Gaps = 96/672 (14%)

Query: 369  NKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAAD 428
            N ++    +E   +E++     L+ +K ES+    +L   V EL A ++E   LR + A+
Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280

Query: 429  DCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRK 488
                L+ ELD +    E+ EK      +  + A + E +    +E   E  +   +L  +
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKG---IKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337

Query: 489  NAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ---GQRKTQEQLEVLESLKQELATS 545
              ++ ++ +  ++ Q + E  +K LE  +  +  Q    ++K  + L  +ESL++     
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397

Query: 546  QRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKL 605
             ++ + L   LE  A +          L++E D L     H+ +  S L K+        
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK-------- 1449

Query: 606  ASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSIS 665
               ++   QL  +++    + +R A E+   +A  + +E   +S A + +  L       
Sbjct: 1450 ---QKKFDQLLAEEKS---ISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFE 1503

Query: 666  SCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEAC 725
               +QL       ++  +D+   +H +                          +    A 
Sbjct: 1504 RQNKQLRADMEDLMSSKDDVGKNVHEL--------------------------EKSKRAL 1537

Query: 726  KQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDK 785
            +Q   E    L  LE+E          +   +  +KA  E  L +  D + EE   L+ K
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL-QTRDEQNEEKKRLLIK 1596

Query: 786  EMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN--------ERILGCCTSLMQAIQVL 837
            ++    A +E      +E   ++ A  +  K+E++        E        +++ ++ L
Sbjct: 1597 QVRELEAELE------DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL 1650

Query: 838  IVASKDLQREIVESGRGTASPKEFYAKNS--------------RWTEGLISASKAVGWGA 883
                KD QRE+ E+    AS  E +A++               +  E L S+ +A     
Sbjct: 1651 QAQMKDYQRELEEA---RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE 1707

Query: 884  TVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVN 943
                + AD +         L+     + A  AQL    + + +++  N+  L    R   
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQL----EEELEEEQSNMELLNDRFRKTT 1763

Query: 944  QATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKE------ 997
                 + A   + +S  +++DN         Q++RQ  + + ++ ELE  ++ +      
Sbjct: 1764 LQVDTLNAELAAERSAAQKSDN------ARQQLERQNKELKAKLQELEGAVKSKFKATIS 1817

Query: 998  --RQKLGELRKK 1007
                K+G+L ++
Sbjct: 1818 ALEAKIGQLEEQ 1829



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 133/679 (19%), Positives = 269/679 (39%), Gaps = 95/679 (13%)

Query: 384  ISGLKAQL---ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDEL 440
            IS L+ +L   E  + E ++   +L G  ++L+  +AE              L+A++DEL
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE--------------LQAQIDEL 1081

Query: 441  RRQ-REDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMA 499
            + Q  +  E+ Q +L+  + +          ++E  +++ +   D   + A   K     
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141

Query: 500  RQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETS 559
            R    +LE  K ELED+L+  + Q + +T+ + EV E LK+ L   + E +  +  ++  
Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE-LKKAL---EEETKNHEAQIQDM 1197

Query: 560  AQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQ 619
             Q  A    E +E  ++     +     ++ L    KEL        + E  + Q  K +
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL--------ACEVKVLQQVKAE 1249

Query: 620  RKMLLVGSRKAAEQVIQDALNQLEEPP--LISCAGSADHLLSTVTSISSCIEQLEKSWSQ 677
             +      RK  +  +Q+   ++ E     +  A  A  L + + ++S+ +E+ EK   +
Sbjct: 1250 SE----HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305

Query: 678  YLACPEDI-SGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSL-------TEACKQYG 729
            +      + S L  +  LL   T   +    ++ +R   E  +SL        EA K   
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKL--NLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363

Query: 730  RETLAYLASL--------EEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGD 781
            ++ LA  + L        ++ G++E+ +  A +  L   +A+ + L              
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEE-AKKKLLKDAEALSQRL-------------- 1408

Query: 782  LVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVAS 841
               +E A     +E    R+++ L      D  V L+   ++        +    L+   
Sbjct: 1409 ---EEKALAYDKLEKTKNRLQQELD-----DLTVDLDHQRQVASNLEKKQKKFDQLLAEE 1460

Query: 842  KDLQ-REIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF 900
            K +  R   E  R  A  +E   K        +S ++A+        +      Q R   
Sbjct: 1461 KSISARYAEERDRAEAEAREKETK-------ALSLARALEEALEAKEEFERQNKQLRADM 1513

Query: 901  EELMVCSHEIAASTAQLVAASKV---KADKDSPNLAQLQQASRGVNQATAGVVASTISGK 957
            E+LM    ++  +  +L  + +    + ++    L +L+   +    A   +  +  + K
Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573

Query: 958  SQIE-ETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAE 1016
            +Q E +    D  +    + K++ +  QVR LE E E +++++ L    KK  E+    +
Sbjct: 1574 AQFERDLQTRDEQN----EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID--LK 1627

Query: 1017 GWEEGTEASPPTLQEVVTE 1035
              E   EA+     EV+ +
Sbjct: 1628 DLEAQIEAANKARDEVIKQ 1646



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 92/443 (20%), Positives = 177/443 (39%), Gaps = 32/443 (7%)

Query: 371  DEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDC 430
            D+ +    RL +E+  L   L++ +    +V   L+    + +  LAE++ +  + A++ 
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQR----QVASNLEKKQKKFDQLLAEEKSISARYAEER 1471

Query: 431  EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
            +   AE       RE   KA      +E   +A E+     + +  +L  +  DL+    
Sbjct: 1472 DRAEAEA------REKETKALSLARALEEALEAKEE----FERQNKQLRADMEDLMSSKD 1521

Query: 491  EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQ 550
            +V K V    +++  LE++ +E+   LE + D+ Q     +L +  +++   A  +R+LQ
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581

Query: 551  VLQGSLETSAQSEANWAAEF-AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609
                  E   +       E  AELE ER       A +++    +  +L+D + ++ +  
Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK----MEIDLKDLEAQIEAAN 1637

Query: 610  ESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIE 669
            ++  ++ K  RK  L    K  ++ +++A    +E        S   L S    I    E
Sbjct: 1638 KARDEVIKQLRK--LQAQMKDYQRELEEARASRDEI-FAQSKESEKKLKSLEAEILQLQE 1694

Query: 670  QLEKSWSQYLACPEDISGLLHSITLLAHLTSDAI-----AHGATTCLRAPPEPADSLTEA 724
            +L  S        ++   L   IT  A   S  +            L    E   S  E 
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754

Query: 725  CKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD 784
                 R+T   + +L  E + E + +    N   +++   +EL       K +EL   V 
Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL-----KAKLQELEGAVK 1809

Query: 785  KEMAATSAAIETATARIEEMLSK 807
             +  AT +A+E    ++EE L +
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQ 1832



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 112/576 (19%), Positives = 224/576 (38%), Gaps = 69/576 (11%)

Query: 439  ELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSM 498
            ++ RQ E+ +     L +++ K    E    +++ K+ +L++    L  +    T+  + 
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905

Query: 499  ARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATS----QRELQVLQG 554
            A + +  L  +K+ELE+ L  +  + + + +E+ ++L++ K+++       + +L   +G
Sbjct: 906  AEEMRARLAAKKQELEEILHDLESRVEEE-EERNQILQNEKKKMQAHIQDLEEQLDEEEG 964

Query: 555  SLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614
            + +     +    A+  ++E+E   L    +   +E   +   + +   +LA  EE    
Sbjct: 965  ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024

Query: 615  LAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKS 674
            LAK + K  ++ S        ++   Q  E       G    L   +  + + I++L+  
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK-- 1082

Query: 675  WSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLA 734
              Q     E++ G              A+A G    L            A K   RE  A
Sbjct: 1083 -LQLAKKEEELQG--------------ALARGDDETLHK--------NNALKVV-RELQA 1118

Query: 735  YLASLEEEGSLENADSTAMRNCLSKIKA-IGEELLPRGLDIKQEELGDLVDKEMAATSAA 793
             +A L+E+   E A     RN   K K  + EE     L+  + EL D +D     T+A 
Sbjct: 1119 QIAELQEDFESEKAS----RNKAEKQKRDLSEE-----LEALKTELEDTLD----TTAAQ 1165

Query: 794  IETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGR 853
             E  T R +E+    +A        + E        +    Q    A ++L  ++ ++  
Sbjct: 1166 QELRTKREQEVAELKKA--------LEEETKNHEAQIQDMRQRHATALEELSEQLEQA-- 1215

Query: 854  GTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAAS 913
                 K F A   +  +GL + +K +     V+          R K +  +   H   + 
Sbjct: 1216 -----KRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSE 1270

Query: 914  TAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTL 973
              +L      KA K    L  +        +          S +SQ+++T  +      L
Sbjct: 1271 GDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL------L 1324

Query: 974  TQIKRQEMDSQVRVLELE---NELQKERQKLGELRK 1006
             +  RQ+++   R+ +LE   N LQ+++++  E RK
Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 143/756 (18%), Positives = 311/756 (41%), Gaps = 99/756 (13%)

Query: 331  DLMDMDASQQNLFDNKFDDIFGSSFSSDPFNF------NSQNGVNKDEKDHLIERLYREI 384
            +L +M+   Q L + K  +I      ++   F       ++    K E + ++  L   +
Sbjct: 874  ELEEMERKHQQLLEEK--NILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV 931

Query: 385  SGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQR 444
               + + + ++ E ++    ++ H+ +LE  L E++  RQ+     E + AE  ++++  
Sbjct: 932  EEEEERNQILQNEKKK----MQAHIQDLEEQLDEEEGARQKL--QLEKVTAEA-KIKKME 984

Query: 445  EDTEKAQRSLSEIERKAQANEQRYSKLKEKYS---ELVQNHADLLRKN----AEVTKQVS 497
            E+    +   S+  ++ +  E R ++   + +   E  +N A +  K     +++ +++ 
Sbjct: 985  EEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK 1044

Query: 498  MARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQ--VLQGS 555
               + + +LE+ K++L+     + DQ      E    ++ LK +LA  + ELQ  + +G 
Sbjct: 1045 KEEKTRQELEKAKRKLDGETTDLQDQ----IAELQAQIDELKLQLAKKEEELQGALARGD 1100

Query: 556  LETSAQSEA-----NWAAEFAELEKERDSLVSGAAHRE-------EELSALRKELQDTQL 603
             ET  ++ A        A+ AEL+++ +S  +     E       EEL AL+ EL+DT  
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160

Query: 604  KLASTEESMCQLAKD--QRKMLLVGSRKAAEQVIQD-------ALNQLEEPPLISCAGSA 654
              A+ +E   +  ++  + K  L    K  E  IQD       AL +L E    +    A
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKA 1220

Query: 655  D-----HLLSTVTSISSC---IEQLEKSWSQYLACPEDIS-GLLHSITLLAHLTSDAIAH 705
            +       L T     +C   + Q  K+ S++     D     LH+           +A 
Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280

Query: 706  GATTCLRAPPEPADSLTEACK---QYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKA 762
             A+         +  L EA K   ++ ++  +  + L++   L   ++    N  S+I+ 
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340

Query: 763  IGEELLPRGLDIKQEELGDL---VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV 819
            + EE     L  +QEE  +    ++K++ A  + +     ++++ L    + +     E 
Sbjct: 1341 LEEE--KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE-----EA 1393

Query: 820  NERILGCCTSLMQAIQVLIVA-------SKDLQREI------VESGRGTASPKEFYAKNS 866
             +++L    +L Q ++   +A          LQ+E+      ++  R  AS  E   K  
Sbjct: 1394 KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE---KKQ 1450

Query: 867  RWTEGLISASKAVGWGATVMVDAADLVVQGR--------GKFEELMVCSHEIAASTAQLV 918
            +  + L++  K++        D A+   + +           EE +    E      QL 
Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510

Query: 919  A-ASKVKADKD--SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQ 975
            A    + + KD    N+ +L+++ R + Q    +       + +++ T++         Q
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 976  IKRQEMDSQVRVLELENELQKERQKLGELRKKHYEL 1011
              + + +  ++  + +NE +K+R  + ++R+   EL
Sbjct: 1571 AMKAQFERDLQTRDEQNE-EKKRLLIKQVRELEAEL 1605



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 55/279 (19%), Positives = 118/279 (42%), Gaps = 41/279 (14%)

Query: 370  KDEKDHLIERLYREISGLKAQLENMKT----------ESQRVVLQLKGHVSELEADLAEQ 419
            +DE    + +L  ++   + +LE  +           ES++ +  L+  + +L+ +LA  
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699

Query: 420  QHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELV 479
            +  R+ A         E DEL  +  ++   + +L + +R+ +A   R ++L+E+  E  
Sbjct: 1700 ERARRHAEQ-------ERDELADEITNSASGKSALLDEKRRLEA---RIAQLEEELEEEQ 1749

Query: 480  QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE-SL 538
             N   L  +  + T QV     A++  ER   +  D+  +  ++  ++ + +L+ LE ++
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLN-AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808

Query: 539  KQELATSQRELQVLQGSLETSAQSEANWAAE---------------FAELEKERDSLVSG 583
            K +   +   L+   G LE   + EA   A                F ++E ER      
Sbjct: 1809 KSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER----RH 1864

Query: 584  AAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM 622
            A   +E++      ++  + +L   EE   +    +RK+
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 50/209 (23%), Positives = 93/209 (44%), Gaps = 31/209 (14%)

Query: 372  EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
            + D+  ++L R+   LKA+L+ ++     V  + K  +S LEA + + +   +Q A +  
Sbjct: 1782 KSDNARQQLERQNKELKAKLQELEGA---VKSKFKATISALEAKIGQLEEQLEQEAKE-- 1836

Query: 432  FLRAELDELRRQREDTEKAQRSLSEI-----------ERKAQANEQRYSKLKEKYSELVQ 480
              RA  ++L R+ E      + L EI           ++  +  E+  +++K+   +L +
Sbjct: 1837 --RAAANKLVRRTE------KKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE 1888

Query: 481  NHADLLRKNA---EVTKQVSMARQAQVDLEREKKELEDSLER---ISDQGQRKTQEQLEV 534
               +  R NA   ++ +++  A +A   L RE   L++ L R   IS    R  + QL  
Sbjct: 1889 AEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLH- 1947

Query: 535  LESLKQELATSQRELQVLQGSLETSAQSE 563
            LE    EL+    E +    +     QSE
Sbjct: 1948 LEGASLELSDDDTESKTSDVNETQPPQSE 1976


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 125/705 (17%), Positives = 260/705 (36%), Gaps = 82/705 (11%)

Query: 328  EKDDLMDMDASQQNLFDNKFDD--IFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREIS 385
            E +D +D  A+QQ L   +  +  I   +   +     +Q    + +    +E L  ++ 
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206

Query: 386  G---LKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442
                +KA LE  K   +    +L   V  L     + +H R++     + L+ + +E  R
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266

Query: 443  QRED----TEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSM 498
             R +      K Q  L  +      ++ + SKL + +S L     D      E  +Q   
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326

Query: 499  ARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLET 558
                   +E EK    + LE   ++ +   ++Q+  L +   ++A  +++++   G LET
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEE-EEEAKHNLEKQIATLHA---QVADMKKKMEDSVGCLET 1382

Query: 559  SAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKD 618
            + + +     +   L +  +  V+     E+  + L++EL D  + L    +S C L K 
Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442

Query: 619  QRKM-------LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQL 671
            Q+K          + ++ A E+   +A  + +E   +S A + +  +     +    +Q 
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQF 1502

Query: 672  EKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRE 731
                   ++  +D+   +H +                          +    A +Q   E
Sbjct: 1503 RTEMEDLMSSKDDVGKSVHEL--------------------------EKSKRALEQQVEE 1536

Query: 732  TLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATS 791
                L  LE+E          +   L  +KA  E  L +G D + EE    + +++    
Sbjct: 1537 MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDL-QGRDEQSEEKKKQLVRQVREME 1595

Query: 792  AAIETATARIEEMLSKSRAGDTGVKLEVNERILGC--------CTSLMQAIQVLIVASKD 843
            A +E      +E   +S A     KLE++ + L              ++ ++ L    KD
Sbjct: 1596 AELE------DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649

Query: 844  LQRE-----------IVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADL 892
              RE           + ++       K   A+  +  E L +A +A         + AD 
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709

Query: 893  VVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVAS 952
            +    GK    +     + A  AQL    + + +++  N   +    +  N     +   
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQL----EEELEEEQGNTELINDRLKKANLQIDQINTD 1765

Query: 953  TISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKE 997
                +S  ++ +N         Q++RQ  + +V++ E+E  ++ +
Sbjct: 1766 LNLERSHAQKNEN------ARQQLERQNKELKVKLQEMEGTVKSK 1804



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 132/669 (19%), Positives = 265/669 (39%), Gaps = 81/669 (12%)

Query: 366  NGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425
            N   ++EK   + +L  +   +   LE      ++   +L+    +LE D  +   L  Q
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD---LSDQ 1063

Query: 426  AADDCEFLRAELDELRRQ-REDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD 484
             A+    L+A++ EL+ Q  +  E+ Q +L+ +E +A        K++E  S++ +   D
Sbjct: 1064 IAE----LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119

Query: 485  LLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELAT 544
            L  + A   K     R    +LE  K ELED+L+  + Q + +++               
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR-------------- 1165

Query: 545  SQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
             ++E+ +L+ +LE  A++     A+  E+ ++    V   A + E+   ++  L+  +  
Sbjct: 1166 -EQEVNILKKTLEEEAKTH---EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221

Query: 605  LASTEESMCQLAKDQRKMLLVG------SRKAAEQVIQDALNQLEEPPLISCAGSADHLL 658
            L   E    +LA ++ K+LL G       RK  E  +Q+   +  E   +     AD + 
Sbjct: 1222 L---ENERGELA-NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR-TELADKVT 1276

Query: 659  STVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPA 718
                 + +    L +S S+     +D S L            ++        L+      
Sbjct: 1277 KLQVELDNVTGLLSQSDSKSSKLTKDFSAL------------ESQLQDTQELLQEENRQK 1324

Query: 719  DSLTEACKQYGRETLAYLASLEEE----GSLENADSTAMRNCLSKIKAIGEEL--LPRGL 772
             SL+   KQ   E  ++   LEEE     +LE   +T         K + + +  L    
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384

Query: 773  DIKQEELGDLV-----DKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCC 827
            ++K++   DL       +E  A    +E    R+++ L      D  V L+   +     
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD-----DLLVDLDHQRQSACNL 1439

Query: 828  TSLMQAIQVLIVASKDLQREIVES-GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVM 886
                +    L+   K +  +  E   R  A  +E   K        +S ++A+       
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETK-------ALSLARALEEAMEQK 1492

Query: 887  VDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKV---KADKDSPNLAQLQQASRGVN 943
             +   L  Q R + E+LM    ++  S  +L  + +    + ++    L +L+   +   
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552

Query: 944  QATAGVVASTISGKSQIE-ETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLG 1002
             A   +  +  + K+Q E +    D  S    + K++++  QVR +E E E +++++ + 
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQS----EEKKKQLVRQVREMEAELEDERKQRSMA 1608

Query: 1003 ELRKKHYEL 1011
               +K  E+
Sbjct: 1609 VAARKKLEM 1617



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 115/501 (22%), Positives = 210/501 (41%), Gaps = 89/501 (17%)

Query: 371  DEKDHLIERLYREISGLKAQLENMKTESQRVV--LQLKGHVS-ELEADLA--EQQHLRQQ 425
            +E++     L ++I+ L AQ+ +MK + +  V  L+    V  +L+ DL    Q+H  + 
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV 1405

Query: 426  AADDCEFLRAELDELRRQRE------DTEKAQRSLSEIERKAQANEQRYSKLKE---KYS 476
            AA D    + E  + R Q+E      D +  ++S   +E+K +  +Q  ++ K    KY+
Sbjct: 1406 AAYD----KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYA 1461

Query: 477  ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE 536
            E  ++ A+   +  E TK +S+AR  +  +E++ +     LER++ Q     + ++E L 
Sbjct: 1462 E-ERDRAEAEAREKE-TKALSLARALEEAMEQKAE-----LERLNKQ----FRTEMEDLM 1510

Query: 537  SLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRK 596
            S K ++  S  EL+  + +LE   Q       +  ELE E  +        E  L A++ 
Sbjct: 1511 SSKDDVGKSVHELEKSKRALE---QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567

Query: 597  ELQ-DTQLKLASTEESMCQLAKDQRKM------------LLVGSRKAAEQVIQDALNQLE 643
            + + D Q +   +EE   QL +  R+M            + V +RK  E  ++D      
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDL----- 1622

Query: 644  EPPLISCAGSADHLLSTVTSISS----CIEQLEK---SWSQYLACPEDISGLLHSITLLA 696
            E  + S   + D  +  +  + +    C+ +L+    S  + LA  ++    L S+    
Sbjct: 1623 EAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM 1682

Query: 697  HLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAY---------LASLEEEGSLEN 747
                + +A       +A  E  +   E     G+  LA          +A LEEE   E 
Sbjct: 1683 IQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ 1742

Query: 748  ADSTAMRNCLSK----IKAIGEEL-LPRG------------------LDIKQEELGDLVD 784
             ++  + + L K    I  I  +L L R                   L +K +E+   V 
Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK 1802

Query: 785  KEMAATSAAIETATARIEEML 805
             +  A+  A+E   A++EE L
Sbjct: 1803 SKYKASITALEAKIAQLEEQL 1823



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 138/646 (21%), Positives = 253/646 (39%), Gaps = 98/646 (15%)

Query: 392  ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTEKA 450
            EN  TE + +  QL          +AE+  L++Q   + E L AE +ELR R     ++ 
Sbjct: 865  ENRLTEMETLQSQL----------MAEKLQLQEQLQAETE-LCAEAEELRARLTAKKQEL 913

Query: 451  QRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREK 510
            +    ++E + +  E+R   L+ +  ++ QN         E+ +Q+     A+  L+ EK
Sbjct: 914  EEICHDLEARVEEEEERCQHLQAEKKKMQQN-------IQELEEQLEEEESARQKLQLEK 966

Query: 511  KELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF 570
               E  L        +K +E+  +LE    +LA  ++ L+       T+   E   +   
Sbjct: 967  VTTEAKL--------KKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL 1018

Query: 571  AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMC-QLAKDQRKMLLVGSRK 629
            A+L+ + +++++    R       R+EL+ T+ KL      +  Q+A+ Q ++  +  + 
Sbjct: 1019 AKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078

Query: 630  A-AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC------- 681
            A  E+ +Q AL ++EE      A   +  L  +  + S I +L++      A        
Sbjct: 1079 AKKEEELQAALARVEEE-----AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133

Query: 682  PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
              D+   L ++      T D+ A  A   LR+  E             +E      +LEE
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTA--AQQELRSKRE-------------QEVNILKKTLEE 1178

Query: 742  EGSLENADSTAMRNCLSK-IKAIGEEL---------LPRGLDIKQEELGDLVD--KEMAA 789
            E     A    MR   S+ ++ + E+L         L +     + E G+L +  K +  
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238

Query: 790  TSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIV 849
                 E    ++E  L + +     VK    ER+    T L   +  L V   ++   + 
Sbjct: 1239 GKGDSEHKRKKVEAQLQELQ-----VKFNEGERVR---TELADKVTKLQVELDNVTGLLS 1290

Query: 850  ES-GRGTASPKEFYAKNSRW--TEGLISASKAVGWG-ATVMVDAADLVVQGRGKFEELMV 905
            +S  + +   K+F A  S+   T+ L+          +T +    D     R + EE   
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE 1350

Query: 906  CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
              H +    A L   VA  K K +     L   ++  R + +         + G SQ  E
Sbjct: 1351 AKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQK--------DLEGLSQRHE 1402

Query: 963  TDNMDFSSMTLTQIK-RQEMDSQVRVLELENELQKERQKLGELRKK 1007
                 +  +  T+ + +QE+D      +L  +L  +RQ    L KK
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELD------DLLVDLDHQRQSACNLEKK 1442



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 122/593 (20%), Positives = 239/593 (40%), Gaps = 96/593 (16%)

Query: 439  ELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSM 498
            ++ RQ E+    +  L ++  K  A E R ++++   S+L+     L  +    T+  + 
Sbjct: 839  QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898

Query: 499  ARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLET 558
            A + +  L  +K+ELE+    I    + + +E+ E  + L+ E    Q+ +Q L+  LE 
Sbjct: 899  AEELRARLTAKKQELEE----ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE- 953

Query: 559  SAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKD 618
                E   A +  +LEK                 A  K+L++ Q+ L   E+  C+LAK+
Sbjct: 954  ----EEESARQKLQLEK-------------VTTEAKLKKLEEEQIIL---EDQNCKLAKE 993

Query: 619  QRKMLLVGSRKAAEQVIQDALNQL--EEPPLISCAGSADHLLSTVTSISSCIEQLEKSWS 676
                     +K  E  I +    L  EE    S A   +   + +T +   + + EK   
Sbjct: 994  ---------KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQ 1044

Query: 677  QYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYL 736
            +       + G    +       SD IA      L+A  + A+   +  K+   E  A L
Sbjct: 1045 ELEKTRRKLEGDSTDL-------SDQIAE-----LQA--QIAELKMQLAKK-EEELQAAL 1089

Query: 737  ASLEEEGSLENADSTAMRNCLSKIKAIGEEL-LPRGLDIKQEELGDLVDKEMAATSAAIE 795
            A +EEE + +N     +R   S+I  + E+L   R    K E+    + +E+ A    +E
Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE 1149

Query: 796  ---TATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESG 852
                +TA  +E+ SK       +K  + E        + +  Q    A ++L  ++ ++ 
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209

Query: 853  RGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG-----------KFE 901
            R  A+              L  A + +      + +   +++QG+G           + +
Sbjct: 1210 RVKAN--------------LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255

Query: 902  ELMVCSHE---IAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958
            EL V  +E   +    A  V   +V+ D  +  L+Q    S  + +  + +       +S
Sbjct: 1256 ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL-------ES 1308

Query: 959  QIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYEL 1011
            Q+++T  +      L +  RQ++    ++ ++E+E    R++L E  +  + L
Sbjct: 1309 QLQDTQEL------LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 103/510 (20%), Positives = 215/510 (42%), Gaps = 71/510 (13%)

Query: 369  NKDEKDHLIERLYREISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLRQQ 425
            +K + D  +++   E+SGL++++E+ +    + Q+ + +L+  + ELE ++  ++  R +
Sbjct: 1076 DKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAK 1135

Query: 426  AADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485
            A      L  EL+E+  + E+   A  +  E+ +K +A  Q+  +  E+ +   +  A  
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1195

Query: 486  LRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRKTQEQLEV 534
            LRK      AE+ +Q+   ++ +  LE+EK E++  ++ ++       + +   ++    
Sbjct: 1196 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRA 1255

Query: 535  LESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHREEE 590
            LE    E+ T + E Q L   L          + E++    E+D+LVS    G     ++
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315

Query: 591  LSALRKELQD---TQLKLASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQVIQ- 636
            +  L+++L++    +  LA   +S    C L ++Q       +  L     KA  +V Q 
Sbjct: 1316 IEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQW 1375

Query: 637  ------DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLH 690
                  DA+ + EE        +   L   +      +E +    +      + +   + 
Sbjct: 1376 RTKYETDAIQRTEE-----LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVE 1430

Query: 691  SITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEG------- 743
             + +    T+ A A      L       D +    KQ   ET A L + ++E        
Sbjct: 1431 DLMIDVERTNAACA-----ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485

Query: 744  -SLENADSTAM----------RNCLSKIKAIGEELLPRGLDIKQ-EELGDLVDKEMAATS 791
              ++NA   ++          +N   +I  + E++   G  I + E++   V++E +   
Sbjct: 1486 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ 1545

Query: 792  AAIETATARIEEMLSKSRAGDTGVKLEVNE 821
            AA+E A A +E    K       ++LE+N+
Sbjct: 1546 AALEEAEASLEHEEGKI----LRIQLELNQ 1571



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 87/425 (20%), Positives = 185/425 (43%), Gaps = 45/425 (10%)

Query: 390  QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEK 449
            QL   K + +  + ++     + E   AE    +++  D+C  L+ ++D+L         
Sbjct: 911  QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL--------- 961

Query: 450  AQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLERE 509
             + +L+++E++  A E +   L E+ + L +  A L ++     K +  A Q  +D   +
Sbjct: 962  -ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK----KALQEAHQQTLD---D 1013

Query: 510  KKELEDSLERISDQGQRKTQEQLEVLE-SLKQELATS---QRELQVLQGSLETSAQSEAN 565
             +  ED +  ++ + + K ++Q++ LE SL+QE       +R  + L+G L+ + +S  +
Sbjct: 1014 LQAEEDKVNTLT-KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMD 1072

Query: 566  WAAEFAELE---KERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM 622
               +  +L+   K+++  +SG   + E+  AL  +LQ    +L +  E + +  + +R  
Sbjct: 1073 IENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAER-- 1130

Query: 623  LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
                SR  AE+   D   +LEE         ++ L     + S+ IE  +K  +++    
Sbjct: 1131 ---ASRAKAEKQRSDLSRELEE--------ISERLEEAGGATSAQIEMNKKREAEFQKMR 1179

Query: 683  EDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEE 742
             D    L   TL    T+  +       +    E  D+L    ++  +E       +++ 
Sbjct: 1180 RD----LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1235

Query: 743  GSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIE 802
             S     S A  N     +A+ ++L    +  K+EE   L++ ++ A  A ++T +    
Sbjct: 1236 ASNMETVSKAKGNLEKMCRALEDQL--SEIKTKEEEQQRLIN-DLTAQRARLQTESGEYS 1292

Query: 803  EMLSK 807
              L +
Sbjct: 1293 RQLDE 1297



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 146/671 (21%), Positives = 260/671 (38%), Gaps = 70/671 (10%)

Query: 387  LKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRED 446
            + A+L   K + +    +LK  + +LE  LA+ +  +    +  + L  E+  L      
Sbjct: 936  INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 995

Query: 447  TEKAQRSLSEIERKA----QANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQA 502
              K +++L E  ++     QA E + + L +   +L Q   D L  + E  K++ M    
Sbjct: 996  LTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ-QVDDLEGSLEQEKKIRM---- 1050

Query: 503  QVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETS--- 559
              DLER K++LE  L+      Q  T +     + L ++L   + E+  LQ  +E     
Sbjct: 1051 --DLERAKRKLEGDLK----LAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQAL 1104

Query: 560  ----AQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQL 615
                 +      A   ELE+E ++  +  A  E++ S L +EL++   +L    E     
Sbjct: 1105 GMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL----EEAGGA 1160

Query: 616  AKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSW 675
               Q +M      K  E   Q     LEE  L   A +A        S++   EQ++   
Sbjct: 1161 TSAQIEM-----NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1215

Query: 676  SQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAY 735
                   ++ S +   I        D +A    T  +A      +L + C+    + L+ 
Sbjct: 1216 RVKQKLEKEKSEMKMEI--------DDLASNMETVSKA----KGNLEKMCRAL-EDQLSE 1262

Query: 736  LASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIE 795
            + + EEE      D TA R  L      GE    R LD K   +  L   + A T   IE
Sbjct: 1263 IKTKEEEQQRLINDLTAQRARLQ--TESGE--YSRQLDEKDTLVSQLSRGKQAFTQ-QIE 1317

Query: 796  TATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGT 855
                ++EE +    A    ++   ++     C  L +  +    A  +LQR + ++    
Sbjct: 1318 ELKRQLEEEIKAKSALAHALQSSRHD-----CDLLREQYEEEQEAKAELQRAMSKANSEV 1372

Query: 856  ASPKEFYAKNS-RWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAAST 914
            A  +  Y  ++ + TE L  A K +   A  + DA + V     K   L      +    
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKL---AQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429

Query: 915  AQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFS-SMTL 973
              L+    +  ++ +   A L +  R  ++  A          +++E +     S S  L
Sbjct: 1430 EDLM----IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485

Query: 974  TQIKR--QEMDSQVRVLELENE-LQKE----RQKLGELRKKHYELAGVAEGWEEGTEASP 1026
             +IK   +E   Q+  L+ EN+ LQ+E     +++ E  K+ +EL  + +  E+      
Sbjct: 1486 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ 1545

Query: 1027 PTLQEVVTEKE 1037
              L+E     E
Sbjct: 1546 AALEEAEASLE 1556



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 121/603 (20%), Positives = 227/603 (37%), Gaps = 66/603 (10%)

Query: 460  KAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLER 519
            K+   E+  + +KE++ +  +  A    K  E+ +++    Q + DL+ + +   DSL  
Sbjct: 845  KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904

Query: 520  ISDQGQR--KTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKER 577
              ++  +  KT+ QLE       E A  + E+     + +   + E       +EL+K+ 
Sbjct: 905  AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC------SELKKDI 958

Query: 578  DSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637
            D L    A  E+E  A   ++++   ++A  +E++ +L K+++ +     ++A +Q + D
Sbjct: 959  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDD 1013

Query: 638  ALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAH 697
               Q EE  + +   +   L   V  +   +EQ +K           + G    + L   
Sbjct: 1014 L--QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG---DLKLAQE 1068

Query: 698  LTSD------------AIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745
             T D                   + L++  E   +L    ++  +E  A +  LEEE   
Sbjct: 1069 STMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEA 1128

Query: 746  ENADSTAMRNCLSKIKAIGEELLPR-----GLDIKQEELGDLVDKEMAATSAAIETATAR 800
            E A         S +    EE+  R     G    Q E+    + E       +E AT +
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188

Query: 801  IEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKE 860
             E   +  R        E+ E+I     +L +  Q L     +++ EI +     AS  E
Sbjct: 1189 HEATAATLRKKHADSVAELGEQI----DNLQRVKQKLEKEKSEMKMEIDD----LASNME 1240

Query: 861  FYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAA 920
                         + SKA G    +     D + + + K EE     +++ A  A+L   
Sbjct: 1241 -------------TVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTE 1287

Query: 921  SKVKADKDSPNLAQLQQASRGVNQATAGV------VASTISGKSQIEETDNMDFSSMTLT 974
            S   + +       + Q SRG    T  +      +   I  KS +     +  S     
Sbjct: 1288 SGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHA--LQSSRHDCD 1345

Query: 975  QIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVT 1034
             ++ Q  + Q    EL+  + K   ++ + R K YE   + +  EE  EA     Q +  
Sbjct: 1346 LLREQYEEEQEAKAELQRAMSKANSEVAQWRTK-YETDAI-QRTEELEEAKKKLAQRLQD 1403

Query: 1035 EKE 1037
             +E
Sbjct: 1404 AEE 1406



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 120/666 (18%), Positives = 258/666 (38%), Gaps = 92/666 (13%)

Query: 417  AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSL----SEIERKAQANEQRYSKLK 472
            AE +       ++ E  + EL +   +R++ E+   +L    ++++ + QA     +  +
Sbjct: 847  AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAE 906

Query: 473  EKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL 532
            E+  +L++    L  K  EVT++     +   +L  +K++LED    +            
Sbjct: 907  ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD--------- 957

Query: 533  EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELS 592
              ++ L+  LA  ++E    +  ++   +  A      A+L KE+ +L        ++L 
Sbjct: 958  --IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015

Query: 593  A------------LRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN 640
            A            ++ E Q   L+ +  +E   ++  ++ K  L G  K A++   D  N
Sbjct: 1016 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEN 1075

Query: 641  ---QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAH 697
               QL+E  L         L S +    +   QL+K   +  A  E++   +      A 
Sbjct: 1076 DKQQLDE-KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIE-----AE 1129

Query: 698  LTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLE-------------EEGS 744
              S A A    + L       + ++E  ++ G  T A +   +             EE +
Sbjct: 1130 RASRAKAEKQRSDL---SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1186

Query: 745  L--ENADSTAMRNCLSKIKAIGEEL-----LPRGLDIKQEELGDLVDKEMAATSAAIETA 797
            L  E   +T  +     +  +GE++     + + L+ ++ E+   +D ++A+    +  A
Sbjct: 1187 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-DLASNMETVSKA 1245

Query: 798  TARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES---- 851
               +E+M    + +  +   K E  +R++   T+    +Q     S +  R++ E     
Sbjct: 1246 KGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQ---TESGEYSRQLDEKDTLV 1302

Query: 852  ---GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSH 908
                RG  +  +   +  R  E  I A  A+           DL+   R ++EE      
Sbjct: 1303 SQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLL---REQYEEEQEAKA 1359

Query: 909  EIAASTAQL---VAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEETD 964
            E+  + ++    VA  + K + D+     +L++A +         +A  +    +  E  
Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQDAEEHVEAV 1411

Query: 965  NMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEA 1024
            N   +S+  T   +Q + ++V   +L  ++++       L KK      +   W++  E 
Sbjct: 1412 NAKCASLEKT---KQRLQNEVE--DLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEE 1466

Query: 1025 SPPTLQ 1030
            +   L+
Sbjct: 1467 THAELE 1472



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 76/363 (20%), Positives = 154/363 (42%), Gaps = 52/363 (14%)

Query: 370  KDEKDHLIERLY---REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426
            ++ K  L +RL      +  + A+  +++   QR+  +++  + ++E   A    L ++ 
Sbjct: 1391 EEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQ 1450

Query: 427  ADDCEFL---RAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELV 479
             +  + L   + + +E   + E ++K  RSLS    +I+   + +  +   LK +   L 
Sbjct: 1451 RNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQ 1510

Query: 480  QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE--------------------- 518
            Q  +DL  + AE  K++    + +  +E+EK EL+ +LE                     
Sbjct: 1511 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELN 1570

Query: 519  RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFA 571
            ++  +  RK  E+ E ++ +K+      R ++ +Q +L+   +S       +     +  
Sbjct: 1571 QVKSEVDRKIAEKDEEIDQMKR---NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1627

Query: 572  ELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLAKDQRKMLLVGS 627
            E+E + +     AA         +  L+DTQL     L S E+   QLA  +R+  L+ +
Sbjct: 1628 EMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQA 1687

Query: 628  -----RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
                 R   EQ   +   ++ E  L+  +     L +  TS+ +  ++LE   SQ     
Sbjct: 1688 EIEELRATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEM 1745

Query: 683  EDI 685
            EDI
Sbjct: 1746 EDI 1748



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 43/236 (18%), Positives = 104/236 (44%), Gaps = 12/236 (5%)

Query: 382  REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
            +E+     +++ + T++  ++   K   +++     E + + Q+A +  E  +  + +  
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAA 1767

Query: 442  RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
               E+ +K Q + + +ER  +  EQ    L+ +  E  Q    L     ++ K  +  R+
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ--LALKGGKKQIQKLEARVRE 1825

Query: 502  AQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSL----- 556
             + ++E E+K   ++++ +  + +RK +E     E  ++ +   Q  +  LQ  +     
Sbjct: 1826 LEGEVESEQKRNVEAVKGLR-KHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKR 1884

Query: 557  ---ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609
               E   QS  N  ++F  ++ E +     A   E +++ LR + ++   K+ S E
Sbjct: 1885 QAEEAEEQSNVN-LSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 114/518 (22%), Positives = 216/518 (41%), Gaps = 86/518 (16%)

Query: 370  KDEKDHLIERLYR---EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLR 423
            +++K  L E+L +   E+S L+ ++E+   +  + Q+ + +L+  + ELE ++  ++  R
Sbjct: 1074 ENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASR 1133

Query: 424  QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
             +A      L  EL+E+  + E+   A  +  E+ +K +A  Q+  +  E+ +   +  A
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATA 1193

Query: 484  DLLRKN-----AEVTKQVSMARQAQVDLEREKKELE-------DSLERISDQGQRKTQEQ 531
              LRK      AE+ +Q+   ++ +  LE+EK EL+        ++E +S + +   ++ 
Sbjct: 1194 AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVS-KAKANFEKM 1252

Query: 532  LEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHR 587
               LE    E+ T + E Q L   L          + EF+    E+D++VS    G    
Sbjct: 1253 CRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAF 1312

Query: 588  EEELSALRKEL-QDTQLK--LASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQV 634
             +++  L+++L ++T+ K  LA   +S    C L ++Q       +  L  G  KA  +V
Sbjct: 1313 TQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEV 1372

Query: 635  IQ-------DALNQLE--EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685
             Q       DA+ + E  E      A         V +++S    LEK+  +     ED+
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDL 1432

Query: 686  SGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745
                        +     ++ A   L       D +    KQ   ET A L + ++E   
Sbjct: 1433 ------------MIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKE--- 1477

Query: 746  ENADSTAMRNCLSKIKAIGEELLPRGLDIK------QEELGDL----------------V 783
                S ++   L K+K   EE L     +K      Q+E+ DL                V
Sbjct: 1478 ----SRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKV 1533

Query: 784  DKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNE 821
             K++    + ++T+    E  L         ++LE+N+
Sbjct: 1534 KKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQ 1571



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 60/296 (20%), Positives = 135/296 (45%), Gaps = 30/296 (10%)

Query: 379  RLYREISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRA 435
            +L +++  L+  LE  K    + +R   +L+G +   +    + ++ +QQ  +  +    
Sbjct: 1030 KLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEF 1089

Query: 436  ELDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAE 491
            E+  L+ + ED +    + Q+ + E++ + +  E+     +   ++  +  +DL R+  E
Sbjct: 1090 EMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149

Query: 492  VTK-----------QVSMARQAQVDLEREKKELEDS----------LERISDQGQRKTQE 530
            +++           Q+ M ++ + + ++ +++LE+S          L +       +  E
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209

Query: 531  QLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEE 590
            Q++ L+ +KQ+L   + EL++    L ++ ++ +   A F ++ +  +  +S    +EEE
Sbjct: 1210 QIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEE 1269

Query: 591  LSALRKEL--QDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
               L  EL  Q  +L   S E S     KD     L   ++A  Q I++   QLEE
Sbjct: 1270 QQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEE 1325



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 75/312 (24%), Positives = 144/312 (46%), Gaps = 44/312 (14%)

Query: 370  KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQH----LRQQ 425
            K + DH    L   +   +A LE+ + +  R+ L+L    SE++  +AE+      L++ 
Sbjct: 1534 KKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRN 1593

Query: 426  AADDCEFLRAELDELRRQREDT----EKAQRSLSEIERKAQ-ANEQRYSKLKEKYSEL-- 478
                 E +++ LD   R R D     +K +  L+E+E +   AN Q    L+   +    
Sbjct: 1594 HLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGI 1653

Query: 479  ---VQNHAD-LLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL-- 532
                Q H D  +R   ++ +Q++M  +    ++ E +EL  SLER +++G++  +++L  
Sbjct: 1654 LKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLER-TERGRKMAEQELLD 1712

Query: 533  -----EVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFA------------ 571
                 ++L +    L  ++++L+     +QG +E   Q EA  A E A            
Sbjct: 1713 ASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQ-EARNAEEKAKKAITDAAMMAE 1771

Query: 572  ELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAA 631
            EL+KE+D+    +AH E     + + ++D QL+L   E+   +  K Q + L    R+  
Sbjct: 1772 ELKKEQDT----SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1827

Query: 632  EQVIQDALNQLE 643
             +V  +  + +E
Sbjct: 1828 SEVESEQKHNVE 1839



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 117/563 (20%), Positives = 210/563 (37%), Gaps = 66/563 (11%)

Query: 460  KAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLER 519
            K+   E+  + +KE++ +  +  A    K  E+ +++    Q + DL+ + +   D+L  
Sbjct: 845  KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904

Query: 520  ISDQGQR--KTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKER 577
              ++  +  KT+ QLE       E A  + E+     + +   + E       +EL+K+ 
Sbjct: 905  AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC------SELKKDI 958

Query: 578  DSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637
            D L    A  E+E  A   ++++   ++A  +E++ +L K+++ +     ++A +Q + D
Sbjct: 959  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDD 1013

Query: 638  ALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAH 697
               Q+EE  + +   +   L   V  +   +EQ +K           + G    + L   
Sbjct: 1014 L--QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEG---DLKLAQE 1068

Query: 698  LTSDA------------IAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745
             T D                   + L+   E   +L    ++  +E  A +  LEEE   
Sbjct: 1069 STMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEA 1128

Query: 746  ENADSTAMRNCLSKIKAIGEELLPR-----GLDIKQEELGDLVDKEMAATSAAIETATAR 800
            E A         S +    EE+  R     G    Q E+    + E       +E +T +
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQ 1188

Query: 801  IEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREI--VESGRGTAS- 857
             E   +  R        E+ E+I     SL +  Q L     +L+ EI  + S   T S 
Sbjct: 1189 HEATAAALRKKHADSVAELGEQI----DSLQRVKQKLEKEKSELKMEINDLASNMETVSK 1244

Query: 858  PKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQL 917
             K  + K  R  E  +S  K                     K EE     +E++A  A+L
Sbjct: 1245 AKANFEKMCRTLEDQLSEIKT--------------------KEEEQQRLINELSAQKARL 1284

Query: 918  VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIK 977
               S   + +     A + Q SRG    T  +       K Q+EE      +     Q  
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEEL----KRQLEEETKAKSTLAHALQSA 1340

Query: 978  RQEMDSQVRVLELENELQKERQK 1000
            R + D      E E E + E Q+
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQR 1363



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 89/428 (20%), Positives = 179/428 (41%), Gaps = 45/428 (10%)

Query: 390  QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEK 449
            QL   K + +  + ++     + E   AE    +++  D+C  L+ ++D+L         
Sbjct: 911  QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL--------- 961

Query: 450  AQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLERE 509
             + +L+++E++  A E +   L E+ + L +  A L ++     K +  A Q  +D    
Sbjct: 962  -ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK----KALQEAHQQTLD---- 1012

Query: 510  KKELEDSLERISDQGQRKTQEQLEVLE-SLKQE---LATSQRELQVLQGSLETSAQS--- 562
              ++E+       + + K ++Q++ LE SL+QE       +R  + L+G L+ + +S   
Sbjct: 1013 DLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMD 1072

Query: 563  EANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM 622
              N   +  E  K+++  +S    + E+  AL  +LQ    +L +  E + +  + +R  
Sbjct: 1073 TENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAER-- 1130

Query: 623  LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
                SR  AE+   D   +LEE         ++ L     + S+ IE  +K  +++    
Sbjct: 1131 ---ASRAKAEKQRSDLSRELEE--------ISERLEEAGGATSAQIEMNKKREAEFQKMR 1179

Query: 683  EDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEE 742
             D    L   TL    T+ A+       +    E  DSL    ++  +E       + + 
Sbjct: 1180 RD----LEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDL 1235

Query: 743  GSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIE 802
             S     S A  N     + + ++L    +  K+EE   L++ E++A  A + T +    
Sbjct: 1236 ASNMETVSKAKANFEKMCRTLEDQL--SEIKTKEEEQQRLIN-ELSAQKARLHTESGEFS 1292

Query: 803  EMLSKSRA 810
              L +  A
Sbjct: 1293 RQLDEKDA 1300



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 65/289 (22%), Positives = 129/289 (44%), Gaps = 55/289 (19%)

Query: 387  LKAQLENMKTESQRVVLQLKGHVSELEADLA---EQQHLRQQAADDCEFLRAELDE---- 439
            + A+L   K + +    +LK  + +LE  LA   +++H  +    +     A LDE    
Sbjct: 936  INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 995

Query: 440  LRRQREDTEKA-QRSLSEI---ERKAQANEQRYSKLKEKYSELVQN-------HADLLRK 488
            L ++++  ++A Q++L ++   E K     +  +KL+++  +L  +         DL R 
Sbjct: 996  LTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA 1055

Query: 489  NAEVTKQVSMARQAQVDLEREKKELEDSLER-----------------ISDQGQRKTQEQ 531
              ++   + +A+++ +D E +K++L + L++                 ++ Q Q+K +E 
Sbjct: 1056 KRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKEL 1115

Query: 532  LEVLESLKQELATSQ--------------RELQVLQGSLE-----TSAQSEANWAAEFAE 572
               +E L++E+   +              REL+ +   LE     TSAQ E N   E AE
Sbjct: 1116 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE-AE 1174

Query: 573  LEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRK 621
             +K R  L       E   +ALRK+  D+  +L    +S+ ++ +   K
Sbjct: 1175 FQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEK 1223



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 74/358 (20%), Positives = 154/358 (43%), Gaps = 53/358 (14%)

Query: 370  KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
            +D ++H +E +  + + L+   + ++ E + +++ ++   +   A   +Q++  +  A+ 
Sbjct: 1402 QDAEEH-VEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAE- 1459

Query: 430  CEFLRAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELVQNHADL 485
                + + +E + + E ++K  RSLS    +++   + +      LK +   L Q  +DL
Sbjct: 1460 ---WKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDL 1516

Query: 486  LRKNAEVTKQVSMARQAQVDLEREKKELEDSLE---------------------RISDQG 524
              + AE  K +    + +  L+ EK EL+ SLE                     ++  + 
Sbjct: 1517 TEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576

Query: 525  QRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFAELEKER 577
             RK  E+ E L+ LK+      R ++ +Q +L+   +S       +     +  E+E + 
Sbjct: 1577 DRKIAEKDEELDQLKR---NHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQL 1633

Query: 578  DSLVSGAAHREEELSALRKELQDTQLKL----ASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
            +     AA     L   +  L+DTQL L       ++   QLA  +R+  L+   +A  +
Sbjct: 1634 NHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLM---QAEVE 1690

Query: 634  VIQDALNQLE------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685
             ++ +L + E      E  L+  +     L +  TS+ +  ++LE   SQ     EDI
Sbjct: 1691 ELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 46/244 (18%), Positives = 102/244 (41%), Gaps = 27/244 (11%)

Query: 417  AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSL----SEIERKAQANEQRYSKLK 472
            AE +       ++ E  + EL +   +R++ E+   +L    ++++ + QA     +  +
Sbjct: 847  AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAE 906

Query: 473  EKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL 532
            E+  +L++    L  K  EVT++     +   +L  +K++LED    +            
Sbjct: 907  ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD--------- 957

Query: 533  EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSL-------VSGAA 585
              ++ L+  LA  ++E    +  ++   +  A      A+L KE+ +L       +    
Sbjct: 958  --IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015

Query: 586  HREEELSALRKELQDTQLKLASTEESMCQLAK-----DQRKMLLVGSRKAAEQVIQDALN 640
              E++++ L K     + ++   E S+ Q  K     ++ K  L G  K A++   D  N
Sbjct: 1016 MEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEN 1075

Query: 641  QLEE 644
              ++
Sbjct: 1076 DKQQ 1079



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 88/501 (17%), Positives = 194/501 (38%), Gaps = 44/501 (8%)

Query: 559  SAQSEANWAAEFAELEKERDSLVSGAAHR---EEELSALRKELQDTQLKLASTEESMCQL 615
            SA++E   A    E EK ++ L    A R   EE++  L +E  D QL++ +  +++   
Sbjct: 846  SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADA 905

Query: 616  AKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSW 675
              ++R   L+ ++   E  I++   + E+   I+   +A               +LE   
Sbjct: 906  --EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK------------RKLEDEC 951

Query: 676  SQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTE---ACKQYGRET 732
            S+     +D+   L  +    H T + + +  T  +    E    LT+   A ++  ++T
Sbjct: 952  SELKKDIDDLELTLAKVEKEKHATENKVKN-LTEEMAGLDETIAKLTKEKKALQEAHQQT 1010

Query: 733  LAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSA 792
            L  L   E++ +      T +   +  ++   E+     +D+++ +     D ++A  S 
Sbjct: 1011 LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQEST 1070

Query: 793  A-IETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES 851
               E    ++ E L K     + ++ ++ +        L + I+ L    ++L+ EI   
Sbjct: 1071 MDTENDKQQLNEKLKKKEFEMSNLQGKIEDE-QALAIQLQKKIKELQARIEELEEEIEAE 1129

Query: 852  GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIA 911
                A  ++  +  SR  E +    +  G   +  ++        + +  E      ++ 
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE------MNKKREAEFQKMRRDLE 1183

Query: 912  ASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE-TDNMDFSS 970
             ST Q  A +     K + ++A+L +    + +    +       K +I +   NM+  S
Sbjct: 1184 ESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVS 1243

Query: 971  MT--------------LTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAE 1016
                            L++IK +E + Q  + EL  +  +   + GE  ++  E   +  
Sbjct: 1244 KAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVS 1303

Query: 1017 GWEEGTEASPPTLQEVVTEKE 1037
                G +A    ++E+  + E
Sbjct: 1304 QLSRGKQAFTQQIEELKRQLE 1324


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 132/695 (18%), Positives = 292/695 (42%), Gaps = 73/695 (10%)

Query: 379  RLYREISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRA 435
            RL +++  L+  LE    ++ +++R   +L+G +   +  +A+    +QQ  +  +   +
Sbjct: 1075 RLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDS 1134

Query: 436  ELDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAE 491
            EL +L  + ED +    + Q+ + E++ +A+  E+     +   + + +  A+  R+  E
Sbjct: 1135 ELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEE 1194

Query: 492  VTKQVSMA-----------RQAQVDLEREKKELED----------SLERISDQGQRKTQE 530
            +++++  A           R+ + +L R ++ELE+          +L R   +G  +  E
Sbjct: 1195 LSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGE 1254

Query: 531  QLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEE 590
            Q++ L+ ++Q+L   + EL++    L  + ++     A   +L +  +  +S A  + EE
Sbjct: 1255 QVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE 1314

Query: 591  LSALRKELQDTQLKLASTEESMCQLAKDQRKML--LVGSRKAAEQVIQDALNQLEEPPLI 648
            L     +    + +L +    + +L +++  ++  L   +  A Q +++   QLEE    
Sbjct: 1315 LQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEE--- 1371

Query: 649  SCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGAT 708
            S A SA  L   V ++    + L +   +      ++  LL              A+   
Sbjct: 1372 SKAKSA--LAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK------------ANAEV 1417

Query: 709  TCLRAPPEPADSL--TEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
               R+  E AD++  TE  ++  ++    L   EE     NA  +++     +++   E+
Sbjct: 1418 AQWRSKYE-ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESED 1476

Query: 767  LLPRGLDIKQ-EELGDLVDKEMAATSAAIETATARIEEM---LSKSRAGDTGVKLEVNER 822
            +    L++++       +DK+      A+E    + EEM   L  ++    G+  E+  R
Sbjct: 1477 VT---LELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTEL-FR 1532

Query: 823  ILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWG 882
            +       ++A++ L   +K+LQ EI       +   +  + + +  + L    KA+  G
Sbjct: 1533 LRHGHEEALEALETLKRENKNLQEEI-------SDLTDQVSLSGKSIQELEKTKKALE-G 1584

Query: 883  ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKV-KADKDSPNLAQLQQASRG 941
                + AA    +G  + EE      ++  S  +     K+ + D++  NL +  Q  R 
Sbjct: 1585 EKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQ--RA 1642

Query: 942  VNQATAGVVASTISGKSQIEETDNMDFS----SMTLTQIKRQEMDSQVRVLELENELQKE 997
            V    A + A T +    +     M+       + L    RQ  ++Q     ++ +L++E
Sbjct: 1643 VESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEE 1702

Query: 998  RQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEV 1032
            +    E ++   EL   A+  E         L+E+
Sbjct: 1703 QAGRDEEQRLAAELHEQAQALERRASLLAAELEEL 1737



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 84/328 (25%), Positives = 147/328 (44%), Gaps = 29/328 (8%)

Query: 370  KDEKDHLIERLY-REISGLKAQLE---NMKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425
            KDE+   + R + R +  L+A L+     + E+ R+  +++G +++LE  L    H  +Q
Sbjct: 1628 KDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLG---HATRQ 1684

Query: 426  AADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSEL--VQNHA 483
            A +     R    +L+ ++   ++ QR  +E+  +AQA E+R S L  +  EL       
Sbjct: 1685 ATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQG 1744

Query: 484  DLLRKNAE-----VTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538
            +  R+ AE      T+++++       L  +KK+LE  L ++S + +   QE+ E  E  
Sbjct: 1745 ERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKA 1804

Query: 539  KQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR--EEELSALRK 596
            K+ +  +    + L+   +TSA  E         ++K  +  V     R  E E +ALR 
Sbjct: 1805 KKAITDAAMMAEELKKEQDTSAHLE--------RMKKTLEQTVRELQARLEEAEQAALRG 1856

Query: 597  ELQDTQLKLASTEESMCQLAKDQRK--MLLVGSRKAAEQVIQDALNQLEE--PPLISCAG 652
              +  Q   A   E   +L  +Q+K    L G RK  E+ +++   Q EE    L     
Sbjct: 1857 GKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRK-HERRVKELAYQAEEDRKNLARMQD 1915

Query: 653  SADHLLSTVTSISSCIEQLEKSWSQYLA 680
              D L S V S     E+ E+  +  LA
Sbjct: 1916 LVDKLQSKVKSYKRQFEEAEQQANTNLA 1943



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 140/653 (21%), Positives = 254/653 (38%), Gaps = 100/653 (15%)

Query: 377  IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
            +E L R+++    Q   ++TES            EL   L E++ L  Q +         
Sbjct: 1312 VEELQRQLADASTQRGRLQTES-----------GELSRLLEEKECLISQLSRGKALAAQS 1360

Query: 437  LDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR----KNAEV 492
            L+ELRRQ E+  KA+ +L+      QA       L+E++ E  +  A+L R     NAEV
Sbjct: 1361 LEELRRQLEEESKAKSALA---HAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEV 1417

Query: 493  ----TKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRE 548
                +K  + A Q   +LE  KK+L   L+  +++G      +   LE  K  L T   +
Sbjct: 1418 AQWRSKYEADAIQRTEELEEAKKKLALRLQE-AEEGVEAANAKCSSLEKAKLRLQTESED 1476

Query: 549  LQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAST 608
            +  L+    TSA          A L+K++  L      R  +   +++EL+  Q +    
Sbjct: 1477 V-TLELERATSAA---------AALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGL 1526

Query: 609  EESMCQLAKDQRKML-LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSC 667
               + +L     + L  + + K   + +Q+ ++ L +   +S +G       ++  +   
Sbjct: 1527 GTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQ--VSLSG------KSIQELEKT 1578

Query: 668  IEQLEKSWSQYLACPEDISGLL---HSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEA 724
             + LE   S+  A  E+  G L    + TL   L    +       L    E   +L   
Sbjct: 1579 KKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLR-- 1636

Query: 725  CKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD 784
             + + R   +  ASL+ E        T  RN                L +K++  GDL D
Sbjct: 1637 -RNHQRAVESLQASLDAE--------TRARN--------------EALRLKKKMEGDLND 1673

Query: 785  KEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQ---VLIVAS 841
             E+    A  +   A+    L +++  +     +  +R+        QA++    L+ A 
Sbjct: 1674 LELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAE 1733

Query: 842  KDLQREIVESGRGT--ASPKEFYAKNSR------WTEGLISASKAVGWGATVMVDAADLV 893
             +  R  +E G  +   + +E      R         GL++  K +      +    +  
Sbjct: 1734 LEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEA 1793

Query: 894  VQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVAST 953
             Q R + EE         A T   + A ++K ++D+   A L++  + + Q    +    
Sbjct: 1794 AQERREAEE-----KAKKAITDAAMMAEELKKEQDTS--AHLERMKKTLEQTVREL---- 1842

Query: 954  ISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRK 1006
               ++++EE +        L   K+Q    + +V ELE EL  E++K  E  K
Sbjct: 1843 ---QARLEEAE-----QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALK 1887



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 146/678 (21%), Positives = 284/678 (41%), Gaps = 114/678 (16%)

Query: 387  LKAQLENMKTESQRVVL------QLKGHVSELEADLAEQQHL-------RQQAADDCEFL 433
            L+A+ +N+    +R  L      QL+G V EL   L +++ +       R++  D+C  L
Sbjct: 940  LQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTEL 999

Query: 434  RAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493
            + ++D+L+           +L++ E++ QA E +   L E+ + L ++ A L ++   + 
Sbjct: 1000 KKDIDDLK----------LTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ 1049

Query: 494  KQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE-SLKQE---LATSQREL 549
            +     +QA  DL+ E    ED +  ++ + + + ++Q+E LE SL+QE      ++R  
Sbjct: 1050 E---AHQQALGDLQAE----EDRVSALT-KAKLRLEQQVEDLECSLEQEKKLRMDTERAK 1101

Query: 550  QVLQGSLETSAQSEANWAAEFAELE---KERDSLVSGAAHREEELSAL----RKELQDTQ 602
            + L+G L+ + +S A+ A +  +LE   K++DS +S  + R E+   L    +K++++ Q
Sbjct: 1102 RKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ 1161

Query: 603  LKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVT 662
             +    EE +   A+   +  +   R  A + +++   +LEE    S AG  +       
Sbjct: 1162 ARAEELEEEL--EAERAARARVEKQRAEAARELEELSERLEEAGGAS-AGQREGCRKREA 1218

Query: 663  SISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLT 722
             +     +LE+            + L H  T+ A       A GA        E  DSL 
Sbjct: 1219 ELGRLRRELEE------------AALRHEATVAALRRKQ--AEGAAEL----GEQVDSLQ 1260

Query: 723  EACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL 782
               ++  +E        + E  +E  D  A    L++ KA  E+L     D   E    +
Sbjct: 1261 RVRQKLEKE--------KSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSE--AKI 1310

Query: 783  VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVAS- 841
              +E+    A   T   R++     + +G+    LE  E    C  S +   + L   S 
Sbjct: 1311 KVEELQRQLADASTQRGRLQ-----TESGELSRLLEEKE----CLISQLSRGKALAAQSL 1361

Query: 842  KDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFE 901
            ++L+R++ E  +  ++              L  A +A+     ++ +  +   + + + +
Sbjct: 1362 EELRRQLEEESKAKSA--------------LAHAVQALRHDCDLLREQHEEEAEAQAELQ 1407

Query: 902  ELMVCSHEIAASTAQLVAASKVKADKD----SPNLA-QLQQASRGVNQATAGVVASTISG 956
             L+  ++   A       A  ++  ++       LA +LQ+A  GV  A A    S++  
Sbjct: 1408 RLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANA--KCSSLEK 1465

Query: 957  KSQIEETDNMDFS-SMTLTQIKRQEMDSQVRVLE--LENELQKERQKLGELRKKHYELAG 1013
                 +T++ D +  +         +D + R LE  LE   ++E +   EL     E  G
Sbjct: 1466 AKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRG 1525

Query: 1014 VA-------EGWEEGTEA 1024
            +         G EE  EA
Sbjct: 1526 LGTELFRLRHGHEEALEA 1543



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 64/280 (22%), Positives = 130/280 (46%), Gaps = 33/280 (11%)

Query: 372  EKDHLIERLYR---EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425
            +K  L E+L +   E+S L  ++E+   +  + Q+ + +L+    ELE +L  ++  R +
Sbjct: 1121 DKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARAR 1180

Query: 426  AADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNH--- 482
                      EL+EL  + E+   A     E  RK +A      +L+ +  E    H   
Sbjct: 1181 VEKQRAEAARELEELSERLEEAGGASAGQREGCRKREA---ELGRLRRELEEAALRHEAT 1237

Query: 483  -ADLLRKN----AEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL---EV 534
             A L RK     AE+ +QV   ++ +  LE+EK EL   ++ ++   +  T+ +    ++
Sbjct: 1238 VAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKL 1297

Query: 535  LESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEK---ERDSLVS----GAAHR 587
              + + +L+ ++ +++ LQ  L  ++        E  EL +   E++ L+S    G A  
Sbjct: 1298 CRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALA 1357

Query: 588  EEELSALRKELQD---TQLKLASTEESM---CQLAKDQRK 621
             + L  LR++L++    +  LA   +++   C L ++Q +
Sbjct: 1358 AQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHE 1397



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 107/504 (21%), Positives = 209/504 (41%), Gaps = 72/504 (14%)

Query: 372  EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
            E +  +E    + S L+     ++TES+ V L+L+   S   A   +Q+HL +       
Sbjct: 1448 EAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERA------ 1501

Query: 432  FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN-- 489
                 L+E RRQ E+    QR L   +R+++       +L+  + E ++    L R+N  
Sbjct: 1502 -----LEERRRQEEEM---QRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKN 1553

Query: 490  -----AEVTKQVSMARQAQVDLEREKKELEDSLERI-SDQGQRKTQEQLEVLESLKQELA 543
                 +++T QVS++ ++  +LE+ KK LE     I +   + +   +LE  ++L+ +L 
Sbjct: 1554 LQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLE 1613

Query: 544  TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRK---ELQD 600
             SQ + +V +   E   +           +E  + SL +    R E L   +K   +L D
Sbjct: 1614 LSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLND 1673

Query: 601  TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLE---EPPLISCAGSADHL 657
             +L+L        Q  + Q    L+ ++   EQ  +D   +L         +    A  L
Sbjct: 1674 LELQLGHATR---QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLL 1730

Query: 658  LSTVTSISSCIEQLEKS---WSQYLACPEDISGLLHSITL------------LAHLTSDA 702
             + +  + + +EQ E+S     Q L    +   LLHS               LA L+ + 
Sbjct: 1731 AAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGE- 1789

Query: 703  IAHGATTCLRAPPEPADSLTEACK-----QYGRETLAYLASL---------EEEGSLENA 748
            +   A     A  +   ++T+A       +  ++T A+L  +         E +  LE A
Sbjct: 1790 VEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEA 1849

Query: 749  DSTAMRNCLSKIKAIGEEL--LPRGLDIKQEELGDLVD---------KEMAATSAAIETA 797
            +  A+R    +++ +  ++  L   LD +Q++  + +          KE+A  +      
Sbjct: 1850 EQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKN 1909

Query: 798  TARIEEMLSKSRAGDTGVKLEVNE 821
             AR+++++ K ++     K +  E
Sbjct: 1910 LARMQDLVDKLQSKVKSYKRQFEE 1933



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 84/381 (22%), Positives = 152/381 (39%), Gaps = 74/381 (19%)

Query: 425  QAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD 484
            QA ++   LRAEL  LR           +L+  E K Q  E+ +  + ++ ++L      
Sbjct: 893  QAEEELAALRAELRGLRG----------ALAAAEAKRQELEETHVSITQEKNDLALQLQA 942

Query: 485  LLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELAT 544
                 A+  ++  +  +++V LE + KEL                E+LE  E +  +LA 
Sbjct: 943  EQDNLADAEERCHLLIKSKVQLEGKVKELS---------------ERLEDEEEVNADLAA 987

Query: 545  SQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
             +R+L+                  E  EL+K+ D L    A  E+E  A   ++++   +
Sbjct: 988  RRRKLE-----------------DECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEE 1030

Query: 605  LASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLE-EPPLISCAGSADHLLSTVTS 663
            +A+ +ES+ +L K+         +KA ++  Q AL  L+ E   +S       L      
Sbjct: 1031 MAALDESVARLTKE---------KKALQEAHQQALGDLQAEEDRVSA------LTKAKLR 1075

Query: 664  ISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTE 723
            +   +E LE S  Q      D       +     LT +++A  A        +    L E
Sbjct: 1076 LEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAA--------QDKQQLEE 1127

Query: 724  ACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL- 782
              K+   E       +E+E  L       M+  + +++A  EEL     +++ E      
Sbjct: 1128 KLKKKDSELSQLSLRVEDEQLL----GAQMQKKIKELQARAEELEE---ELEAERAARAR 1180

Query: 783  VDKEMAATSAAIETATARIEE 803
            V+K+ A  +  +E  + R+EE
Sbjct: 1181 VEKQRAEAARELEELSERLEE 1201



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 106/490 (21%), Positives = 197/490 (40%), Gaps = 71/490 (14%)

Query: 559  SAQSEANWAAEFAELEKERDSLVSGAAHR---EEELSALRKELQDTQLKLASTEESMCQL 615
            SAQ+E   AA  AEL   R +L +  A R   EE   ++ +E  D  L+L + ++++   
Sbjct: 891  SAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLAD- 949

Query: 616  AKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISC--AGSADHLLSTVTSISSCIEQLE- 672
              ++R  LL+ S+   E  +++   +LE+   ++   A     L    T +   I+ L+ 
Sbjct: 950  -AEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008

Query: 673  ---KSWSQYLACPEDISGLLHSITLL----AHLTSDAIA-----HGATTCLRAPPEPADS 720
               K+  +  A    +  L   +  L    A LT +  A       A   L+A  +   +
Sbjct: 1009 TLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSA 1068

Query: 721  LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG 780
            LT+A  +  ++      SLE+E  L      A R             L   L + QE + 
Sbjct: 1069 LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRK------------LEGDLKLTQESVA 1116

Query: 781  DLV-DKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV-NERILGCCTSLMQAIQVLI 838
            D   DK+             ++EE L K  +  + + L V +E++LG    + + I+ L 
Sbjct: 1117 DAAQDKQ-------------QLEEKLKKKDSELSQLSLRVEDEQLLG--AQMQKKIKELQ 1161

Query: 839  VASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG 898
              +++L+ E+       A  ++  A+ +R  E L    +  G  +    +         G
Sbjct: 1162 ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELG 1221

Query: 899  KFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958
            +    +    E A      VAA + K  + +  L +   + + V Q            KS
Sbjct: 1222 RLRREL---EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLE-------KEKS 1271

Query: 959  QIE-ETDNMDFSSMTLTQIKR-----------QEMDSQVRVLELENELQKERQKLGELRK 1006
            ++  E D++  +  TLT+ K            Q  +++++V EL+ +L     + G L+ 
Sbjct: 1272 ELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQT 1331

Query: 1007 KHYELAGVAE 1016
            +  EL+ + E
Sbjct: 1332 ESGELSRLLE 1341



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 69/326 (21%), Positives = 125/326 (38%), Gaps = 56/326 (17%)

Query: 737  ASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIET 796
            A  EEE +   A+   +R  L+  +A  +EL    + I QE+       ++A    A + 
Sbjct: 892  AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEK------NDLALQLQAEQD 945

Query: 797  ATARIEE---MLSKSRAGDTGVKLEVNERI---------LGC--------CTSLMQAIQ- 835
              A  EE   +L KS+    G   E++ER+         L          CT L + I  
Sbjct: 946  NLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDD 1005

Query: 836  -VLIVASKDLQREIVESG-----RGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDA 889
              L +A  + +++  E+         A+  E  A+ ++  + L  A +          D 
Sbjct: 1006 LKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDR 1065

Query: 890  ADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGV 949
               + + + + E+      ++      L    K++ D +     + ++   G  + T   
Sbjct: 1066 VSALTKAKLRLEQ------QVEDLECSLEQEKKLRMDTE-----RAKRKLEGDLKLTQES 1114

Query: 950  VASTISGKSQIEET---DNMDFSSMTL---------TQIKRQEMDSQVRVLELENELQKE 997
            VA     K Q+EE     + + S ++L          Q++++  + Q R  ELE EL+ E
Sbjct: 1115 VADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAE 1174

Query: 998  RQKLGELRKKHYELAGVAEGWEEGTE 1023
            R     + K+  E A   E   E  E
Sbjct: 1175 RAARARVEKQRAEAARELEELSERLE 1200



 Score = 30.4 bits (67), Expect = 9.0
 Identities = 24/112 (21%), Positives = 52/112 (46%), Gaps = 14/112 (12%)

Query: 377  IERLYREISGLKAQLENMKTESQRVVLQLKGH---VSELEADLAEQQHLRQQAADDCEFL 433
            +++L  ++  L+A+L+  + +    +  ++ H   V EL     E +    +  D  + L
Sbjct: 1861 VQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKL 1920

Query: 434  RAELDELRRQREDTE-----------KAQRSLSEIERKAQANEQRYSKLKEK 474
            ++++   +RQ E+ E           KAQ  L + E +A   E + +KL+ +
Sbjct: 1921 QSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRAR 1972


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 153/707 (21%), Positives = 283/707 (40%), Gaps = 102/707 (14%)

Query: 365  QNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQ 424
            Q    + +++  + RL +E    +A L   K     + ++L+  ++E   + A  Q    
Sbjct: 994  QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053

Query: 425  QAADDCEFLRAELDELR----RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSE--- 477
             A  + E    EL +LR     Q ++ E+ ++++ +++ +    E+ ++      SE   
Sbjct: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113

Query: 478  --------LVQNHADLLRKNAEVTKQVSMARQAQVDLEREKK---ELEDSLERISDQGQR 526
                    L    A++ +   +  KQ   A   +  LE E+    E + +LE +  Q + 
Sbjct: 1114 RTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE 1173

Query: 527  KTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAH 586
            K QE    L   +  LA++QREL   +  ++  +++E  W A+ A   +E +   S  + 
Sbjct: 1174 KAQE----LGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISS 1229

Query: 587  REEELS-----ALRKELQDTQLK-LASTEESMCQLAKDQRKMLLV----GSRKAAEQ--V 634
             EEE+S      L KE +  +LK L   E    Q  +++ ++L       S +AAE+   
Sbjct: 1230 LEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSA 1289

Query: 635  IQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLE---KSWSQYLACPEDISGLLHS 691
            +++ +  L E        S ++L   +TS +   E+L    K+W +     E        
Sbjct: 1290 LREEVQSLREEAEKQRVAS-ENLRQELTSQAERAEELGQELKAWQEKFFQKEQA------ 1342

Query: 692  ITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADST 751
                  L++  + H +T  L +   PA  L   C+Q   E  A  A       LE +   
Sbjct: 1343 ------LSTLQLEHTSTQALVSELLPAKHL---CQQLQAEQAA--AEKRHREELEQSKQA 1391

Query: 752  AMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD-----KEMAATSAAIETATARIEEMLS 806
            A          +  ELL       Q ELG+L+       E   T+  +    A   E LS
Sbjct: 1392 A--------GGLRAELLR-----AQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLS 1438

Query: 807  KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPK-EFYAKN 865
              +    G+  E N  +        Q ++V +  +++   + + + R  A  +     + 
Sbjct: 1439 MLKKAH-GLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQRE 1497

Query: 866  SRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASK--- 922
            ++ T   +    A   GA V       V++ R +F+E      ++ A   QL    +   
Sbjct: 1498 AQSTARELEVMTAKYEGAKVK------VLEERQRFQEE---RQKLTAQVEQLEVFQREQT 1548

Query: 923  VKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMD 982
             + ++ S  LA   QAS+   Q    V A    G+SQ E        +    Q+ ++E  
Sbjct: 1549 KQVEELSKKLADSDQASKVQQQKLKAVQAQ--GGESQQEAQRLQAQLNELQAQLSQKEQA 1606

Query: 983  SQVRVLELE-------------NELQKERQKLGELRKKHYELAGVAE 1016
            ++   L++E              ELQ++ + L +L+K++ EL   AE
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAE 1653



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 142/686 (20%), Positives = 269/686 (39%), Gaps = 80/686 (11%)

Query: 370  KDEKDHLIERLYRE---ISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426
            K+++  L + L ++     GL+ Q+E + +  ++   QLK    + EA   +       A
Sbjct: 529  KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588

Query: 427  ADDCEFLRAELDELRRQREDTEKAQRSLSEI-ERKAQANEQRYSKLKEKYSELVQNHADL 485
            A++ E    E D   +Q E  EK + +  EI +++ Q   +     +   ++  +  A+L
Sbjct: 589  AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648

Query: 486  LRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATS 545
             RK  E+   V  ARQ Q + + +  ELE  L R   Q   + +   +  + L+++L   
Sbjct: 649  SRKVEELQACVETARQEQHEAQAQVAELELQL-RSEQQKATEKERVAQEKDQLQEQLQAL 707

Query: 546  QRELQVLQGSLETSAQSEANWAAE----FAELEKERDSLVSGAAHREEELSALRKELQDT 601
            +  L+V +GSLE   +  A+   E     +EL+ E  SLV    H+ E     RKEL++ 
Sbjct: 708  KESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE--QHKRE-----RKELEEE 760

Query: 602  QLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLI------------S 649
            +      E  + QL +  +    V  R+ AE +      + E   L+            S
Sbjct: 761  RAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS 820

Query: 650  CAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATT 709
                A +       + +  E+ EK+  +     E ++G+     L      + +A     
Sbjct: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880

Query: 710  CLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENAD----STAMRNCLSKIKAIGE 765
              RA  +  +    A     ++    L++L+E+ +  + +     T +R    + +    
Sbjct: 881  LARALQQVQEKEVRA-----QKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASR 935

Query: 766  ELL---PRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNER 822
            EL+    R  D + E L +   ++  +T AA++      E+M         G +LE    
Sbjct: 936  ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM---------GNELERLRA 986

Query: 823  ILGCCTSLMQAIQVLIVASKDLQREIVESGRGTAS---PKEFYAKNSRWTEGLISASKAV 879
             L    S  Q  +      +++ R   E GR  A     K   A+     +  ++  +  
Sbjct: 987  AL--MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVE 1044

Query: 880  GWGATVMVDAADLVVQGRGKFEEL---------MVCSHEIAASTAQLVAASKVKADKDSP 930
               AT+    A  + +  GK +EL          +   E    T + +     K +K+  
Sbjct: 1045 --FATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHA 1102

Query: 931  NLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLEL 990
            + +  Q  + G  + T   + +  +  S++E+            Q ++++ DS  R LE 
Sbjct: 1103 SGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ----------CQKQQEQADSLERSLEA 1152

Query: 991  ENELQKERQKL-----GELRKKHYEL 1011
            E   + ER        G+L +K  EL
Sbjct: 1153 ERASRAERDSALETLQGQLEEKAQEL 1178



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 142/705 (20%), Positives = 266/705 (37%), Gaps = 98/705 (13%)

Query: 391  LENMKTESQRVVLQL---KGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDT 447
            L+  + + +R+  QL   + +  ELE +LAE + L  +       ++  +D L    E  
Sbjct: 209  LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268

Query: 448  EKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLE 507
              +     E+E     NE    +L E   +      DL  + +++ ++++   +   DL 
Sbjct: 269  AASPLEPKELEELRDKNESLTMRLHETLKQC----QDLKTEKSQMDRKINQLSEENGDLS 324

Query: 508  REKKE-------LEDSLERISDQGQRKTQEQLEVLESLKQELATS-------QRELQVLQ 553
             + +E       L+D+L  ++++  + TQE LE    L++EL+ +       + + ++LQ
Sbjct: 325  FKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQ 384

Query: 554  GSL----ETSAQSEANWAAEFAE----------LEKERDSLVSGAAHREEELSALRKELQ 599
            G L    E  +Q + N   E  E          L++E  +L +     +  +  L  E  
Sbjct: 385  GKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERG 444

Query: 600  DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQ--DALNQLEEPPLISCAGSADHL 657
              + KL + E    +  K Q   L+   + +   + Q  + L Q  +            L
Sbjct: 445  QQEAKLLA-ERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503

Query: 658  LSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEP 717
             S +T++++ I+Q ++  +      ++    L          S  + H       +  + 
Sbjct: 504  TSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQK 563

Query: 718  ADSL------TEACKQYGRETLAYLASLEEEGSLENADSTAMR-NCLSKIKAIGEELLPR 770
               L       EA +Q   + LA  A+ E E SL   D+   +   L K KA   E+L +
Sbjct: 564  EQQLKEVAEKQEATRQDHAQQLA-TAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622

Query: 771  GLDIKQEELGDL------VDKEMAATSAAIE-----TATARIEEMLSKSRAGDTGVKLE- 818
             L +  E             +E A  S  +E       TAR E+  ++++  +  ++L  
Sbjct: 623  QLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS 682

Query: 819  ------VNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGL 872
                    ER+      L + +Q L  + K  +  + E  R  A   E   +        
Sbjct: 683  EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR-------C 735

Query: 873  ISASKAVGWGATVMVDAADLVVQ---GRGKFEELMVCSHEIAASTAQLVAASKVKADKDS 929
            IS  KA         +   LV Q    R + EE       + A   QL  A + + +   
Sbjct: 736  ISELKA---------ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLR 786

Query: 930  PNLAQLQQASRGVNQATAGVVASTISGKSQIEET--DNMDFSSMTLTQI----------- 976
              LA+   A          +V    + + + E++  +   + +M   Q+           
Sbjct: 787  RELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846

Query: 977  -KRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE 1020
             + QE   +V  +E  +ELQ  RQ+  EL + H  LA   +  +E
Sbjct: 847  QELQEAKEKVAGIESHSELQISRQQ-NELAELHANLARALQQVQE 890



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 133/559 (23%), Positives = 219/559 (39%), Gaps = 74/559 (13%)

Query: 503  QVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQ-RELQVLQGSLETSAQ 561
            Q  + R KK+L D         +R  +++LE+  +  ++L T +  ++ ++Q  ++  A 
Sbjct: 213  QFQMRRLKKQLAD---------ERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL 263

Query: 562  SEANWAA---EFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKD 618
                 AA   E  ELE+ RD   S      E L    K+ QD + + +  +  + QL+++
Sbjct: 264  LNEKQAASPLEPKELEELRDKNESLTMRLHETL----KQCQDLKTEKSQMDRKINQLSEE 319

Query: 619  QRKMLLVGSRKAAE-QVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCIE-- 669
               +       A+  Q +QDALN+L E         +      +  LS       C+E  
Sbjct: 320  NGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEK 379

Query: 670  ---------QLEKSWSQYLACPEDISG-LLHSITLLAHLTSDAIAHGAT-TCLRAPPEPA 718
                     QLE+  SQ    P    G +L  +  L  L  +A    A  T L+A  E  
Sbjct: 380  NEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEML 439

Query: 719  DSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEE 778
            +  TE  +Q  +  LA     EEE    ++  T +++ +S +    EEL     +   + 
Sbjct: 440  E--TERGQQEAK-LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEEL-----EQASQA 491

Query: 779  LGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLI 838
             G  +  ++A+ ++ + T  A I++   +      G+K +  E+      +L Q  Q   
Sbjct: 492  HGARLTAQVASLTSELTTLNATIQQQDQEL----AGLKQQAKEKQAQLAQTLQQQEQ--- 544

Query: 839  VASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG 898
             AS+ L+ + VE    +   KE   K             A    AT    A  L      
Sbjct: 545  -ASQGLRHQ-VEQLSSSLKQKEQQLKEV-----------AEKQEATRQDHAQQLATAA-- 589

Query: 899  KFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958
              EE      E  A+  QL A  K KA K    L  LQQ  +  N+A      S    + 
Sbjct: 590  --EEREASLRERDAALKQLEALEKEKAAK----LEILQQQLQVANEARDSAQTSVTQAQR 643

Query: 959  QIEETDNMDFSSMTLTQIKRQEM-DSQVRVLELENELQKERQKLGELRKKHYELAGVAEG 1017
            +  E            +  RQE  ++Q +V ELE +L+ E+QK  E  +   E   + E 
Sbjct: 644  EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ 703

Query: 1018 WEEGTEASPPTLQEVVTEK 1036
             +   E+   T   +  EK
Sbjct: 704  LQALKESLKVTKGSLEEEK 722



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 55/275 (20%), Positives = 112/275 (40%), Gaps = 12/275 (4%)

Query: 353  SSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSEL 412
            +S++         +G+  +E   L ER       L+ +L+  +   ++ V +L    ++ 
Sbjct: 1431 ASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAR---EKYVQELAAVRADA 1487

Query: 413  EADLAEQQHLRQQAADDCEFLRAE--------LDELRRQREDTEKAQRSLSEIERKAQAN 464
            E  LAE Q   Q  A + E + A+        L+E +R +E+ +K    + ++E   +  
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQ 1547

Query: 465  EQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQG 524
             ++  +L +K ++  Q      +K   V  Q   ++Q    L+ +  EL+  L +  +Q 
Sbjct: 1548 TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ-KEQA 1606

Query: 525  QRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGA 584
                + Q+E  ++         +ELQ    SLE   +      AE   L  E        
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKT 1666

Query: 585  AHREEELSALRKELQDTQLKLASTEESMCQLAKDQ 619
               E+    L  +++  + ++A  ++ +  L K Q
Sbjct: 1667 KEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQ 1701


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 109/507 (21%), Positives = 217/507 (42%), Gaps = 64/507 (12%)

Query: 370  KDEKDHLIERLYR---EISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLR 423
            ++EK  L E+L +   EIS L++++E+ +    + Q+ + +L+  + ELE ++  ++  R
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135

Query: 424  QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
             +A      L  EL+E+  + E+   A  +  E+ +K +A  Q+  +  E+ +   +  A
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195

Query: 484  DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRKTQEQL 532
              LRK      AE+ +Q+   ++ +  LE+EK E++  ++ ++       + +   ++  
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255

Query: 533  EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHRE 588
              LE    EL + + E Q L   L          + EF+    E+++LVS    G     
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315

Query: 589  EELSALRKELQD---TQLKLASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQVI 635
            +++  L+++L++    +  LA   +S    C L ++Q       +  L     KA  +V 
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375

Query: 636  Q-------DALNQLEE-----PPLISCAGSADHLLSTV----TSISSCIEQLEKSWSQYL 679
            Q       DA+ + EE       L     +A+  +  V     S+    ++L+      +
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435

Query: 680  ACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETL----AY 735
               E  +    ++          +A     C     E   S  EA +  G E      AY
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEA-RSLGTELFKIKNAY 1494

Query: 736  LASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQ-EELGDLVDKEMAATSAAI 794
              SL++  +L+  +    +N   +I  + E++   G  I + E++   V++E     AA+
Sbjct: 1495 EESLDQLETLKREN----KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550

Query: 795  ETATARIEEMLSKSRAGDTGVKLEVNE 821
            E A A +E    K       ++LE+N+
Sbjct: 1551 EEAEASLEHEEGKI----LRIQLELNQ 1573



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 98/462 (21%), Positives = 191/462 (41%), Gaps = 77/462 (16%)

Query: 240  VKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFL 299
            +KL FK+   L +   +       E+F K+KD   +S   +       +  L E     L
Sbjct: 836  MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895

Query: 300  RASALSEHISPV-----------VVIPAEASSPDSEPVLEKDDLMDMDASQQNLFD---- 344
            +  A +E ++             + + A+          E++   ++ A ++ L D    
Sbjct: 896  QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955

Query: 345  --NKFDDIFGSSFSSDPFNFNSQNGV-NKDEK----DHLIERLYREISGL----KAQLEN 393
                 DD+  +    +     ++N V N  E+    D  I +L +E   L    +  L++
Sbjct: 956  LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015

Query: 394  MKTESQRV------VLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRE-D 446
            ++ E  +V       ++L+  V +LE  L +++ LR            +L+  +R+ E D
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-----------DLERAKRKLEGD 1064

Query: 447  TEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD--------------LLRKNAEV 492
             + AQ S+ +IE + Q  +++  K + + S L     D              L  +  E+
Sbjct: 1065 LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL 1124

Query: 493  TKQVSMARQAQVDLEREKKELEDSLERISDQGQR---KTQEQLEVLESLKQELATSQREL 549
             +++   R ++   E+++ +L   LE IS++ +     T  Q+E+ +  + E    +R+L
Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1184

Query: 550  QVLQGSLE---TSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD------ 600
            +  + +L+   T+A      A   AEL ++ D+L       E+E S ++ E+ D      
Sbjct: 1185 E--EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242

Query: 601  TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQL 642
            T  K     E MC+  +DQ   L     K+ E+  Q  +N L
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSEL-----KSKEEEQQRLINDL 1279



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 95/516 (18%), Positives = 218/516 (42%), Gaps = 77/516 (14%)

Query: 377  IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
            +E+   ++ G   Q + ++ + +R   +L+G +   +  + + ++ +QQ  +  +    E
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE 1092

Query: 437  LDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492
            +  L+ + ED +    + Q+ + E++ + +  E+     +   ++  +  +DL R+  E+
Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152

Query: 493  TK-----------QVSMARQAQVDLEREKKELED----------SLERISDQGQRKTQEQ 531
            ++           Q+ M ++ + + ++ +++LE+          +L +       +  EQ
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212

Query: 532  LEVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587
            ++ L+ +KQ+L   + E+++    L  ++ET ++++ N       LE +   L S    +
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS----K 1268

Query: 588  EEELSALRKEL--QDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEP 645
            EEE   L  +L  Q  +L+  S E S     K+     L   ++A  Q I++   QLEE 
Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328

Query: 646  PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705
              I    +  H L +       + +      QY    E  + L  +++      +  +A 
Sbjct: 1329 --IKAKNALAHALQSSRHDCDLLRE------QYEEEQESKAELQRALS----KANTEVAQ 1376

Query: 706  GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGE 765
              T       +  + L EA K+  +     L + EE     NA   ++     +++   E
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQR----LQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432

Query: 766  ELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLS--KSRAGDTGVKLEVNE-- 821
            +L+   LD+++            A  AA++      +++L+  K +  +T  +LE ++  
Sbjct: 1433 DLM---LDVERTN----------AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE 1479

Query: 822  ---------RILGCCTSLMQAIQVLIVASKDLQREI 848
                     +I       +  ++ L   +K+LQ+EI
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEI 1515



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 136/675 (20%), Positives = 268/675 (39%), Gaps = 69/675 (10%)

Query: 372  EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHL-------RQ 424
            EK+ L  ++  E  GL A  E    +  +  +QL+  + E+     +++ +       ++
Sbjct: 889  EKNDLQLQVQAEAEGL-ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKR 947

Query: 425  QAADDCEFLRAELDELRRQREDTEK----AQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480
            +  D+C  L+ ++D+L       EK     +  +  +  +    ++  +KL ++   L +
Sbjct: 948  KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007

Query: 481  NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRK------- 527
             H   L        +V+   +A++ LE++  +LE SLE+        ++ +RK       
Sbjct: 1008 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067

Query: 528  TQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587
             QE +  +E+ KQ+L    ++ +    +L++  + E    A   +L+K+   L +     
Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE---QALGIQLQKKIKELQARIEEL 1124

Query: 588  EEELSALR-------KELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN 640
            EEE+ A R       K+  D   +L    E + +        + +  ++ AE   Q    
Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE--FQKMRR 1182

Query: 641  QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS 700
             LEE  L   A +A        S++   EQ++          ++ S +   I        
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI-------- 1234

Query: 701  DAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKI 760
            D +A    T  +A      +L + C+    + L+ L S EEE      D TA R  L   
Sbjct: 1235 DDLASNVETVSKA----KGNLEKMCRTL-EDQLSELKSKEEEQQRLINDLTAQRGRLQ-- 1287

Query: 761  KAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN 820
               GE    R LD K+  +  L   + A T   IE    ++EE +    A    ++   +
Sbjct: 1288 TESGE--FSRQLDEKEALVSQLSRGKQAFTQ-QIEELKRQLEEEIKAKNALAHALQSSRH 1344

Query: 821  ERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNS-RWTEGLISASKAV 879
            +     C  L +  +    +  +LQR + ++    A  +  Y  ++ + TE L  A K +
Sbjct: 1345 D-----CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399

Query: 880  G---WGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQ-L 935
                  A   V+A +       K ++ +    E      +   A+    DK   N  + L
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459

Query: 936  QQASRGVNQATAGVVASTISGKS---QIEETDNMDFSSM-TLTQIKRQEMDSQVRVLELE 991
             +  +   +  A + AS    +S   ++ +  N    S+  L  +KR+  + Q  + +L 
Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1519

Query: 992  NELQKERQKLGELRK 1006
             ++ +  +++ EL K
Sbjct: 1520 EQIAEGGKRIHELEK 1534



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 68/284 (23%), Positives = 129/284 (45%), Gaps = 42/284 (14%)

Query: 388  KAQLENMKTESQRVVLQLKGHVSELEADLAEQQH----LRQQAADDCEFLRAELDELRRQ 443
            +A LE+ + +  R+ L+L    SE++  +AE+      L++      E +++ LD   R 
Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS 1613

Query: 444  REDT----EKAQRSLSEIE-------RKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492
            R D     +K +  L+E+E       R A    + Y   +    +   +  D LR   ++
Sbjct: 1614 RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673

Query: 493  TKQVSMARQAQVDLEREKKELEDSLE------RISDQGQRKTQEQLEVLESLKQELATSQ 546
             +Q++M  +    L+ E +EL  +LE      +I++Q      E++++L +    L  ++
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1733

Query: 547  RELQV----LQGSLETSAQSEANWAAEFA------------ELEKERDSLVSGAAHREEE 590
            ++L+     +QG +E   Q EA  A E A            EL+KE+D+    +AH E  
Sbjct: 1734 KKLETDISQMQGEMEDILQ-EARNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERM 1788

Query: 591  LSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQV 634
               + + ++D QL+L   E+   +  K Q + L    R+   +V
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1832



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 120/668 (17%), Positives = 260/668 (38%), Gaps = 89/668 (13%)

Query: 410  SELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYS 469
            +E E ++A  +   Q+  D+     A+  EL  +     K +   ++++ + QA  +  +
Sbjct: 849  AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK---NDLQLQVQAEAEGLA 905

Query: 470  KLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQ 529
              +E+  +L++    L  K  EVT++     +   +L  +K++LED    +         
Sbjct: 906  DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD------ 959

Query: 530  EQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREE 589
                 ++ L+  LA  ++E    +  ++   +  A      A+L KE+ +L        +
Sbjct: 960  -----IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014

Query: 590  ELSA------------LRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637
            +L A            ++ E Q   L+ +  +E   ++  ++ K  L G  K A++ I D
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074

Query: 638  ALNQLE--EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695
              N+ +  +  L        +L S +    +   QL+K   +  A  E++   +      
Sbjct: 1075 IENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE----- 1129

Query: 696  AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLE-------------EE 742
            A   S A A    + L       + ++E  ++ G  T A +   +             EE
Sbjct: 1130 AERASRAKAEKQRSDL---SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186

Query: 743  GSL--ENADSTAMRNCLSKIKAIGEEL-----LPRGLDIKQEELGDLVDKEMAATSAAIE 795
             +L  E   +T  +     +  +GE++     + + L+ ++ E+   +D ++A+    + 
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-DLASNVETVS 1245

Query: 796  TATARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES-- 851
             A   +E+M    + +  +   K E  +R++   T+    +Q     S +  R++ E   
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ---TESGEFSRQLDEKEA 1302

Query: 852  -----GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVC 906
                  RG  +  +   +  R  E  I A  A+           DL+   R ++EE    
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL---REQYEEEQES 1359

Query: 907  SHEIAASTAQL---VAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
              E+  + ++    VA  + K + D+     +L++A +         +A  +    +  E
Sbjct: 1360 KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVE 1411

Query: 963  TDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022
              N   +S+  T   +Q + ++V  L L  ++++       L KK      +   W++  
Sbjct: 1412 AVNAKCASLEKT---KQRLQNEVEDLML--DVERTNAACAALDKKQRNFDKILAEWKQKC 1466

Query: 1023 EASPPTLQ 1030
            E +   L+
Sbjct: 1467 EETHAELE 1474



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 75/363 (20%), Positives = 153/363 (42%), Gaps = 52/363 (14%)

Query: 370  KDEKDHLIERLY---REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426
            ++ K  L +RL      +  + A+  +++   QR+  +++  + ++E   A    L ++ 
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452

Query: 427  ADDCEFL---RAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELV 479
             +  + L   + + +E   + E ++K  RSL     +I+   + +  +   LK +   L 
Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQ 1512

Query: 480  QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE--------------------- 518
            Q  +DL  + AE  K++    + +  +E+EK EL+ +LE                     
Sbjct: 1513 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELN 1572

Query: 519  RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFA 571
            ++  +  RK  E+ E ++ LK+      R ++ +Q +L+   +S       +     +  
Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKR---NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629

Query: 572  ELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLAKDQRKMLLVGS 627
            E+E + +     AA         +  L+DTQ+     L S E+   QLA  +R+  L+ +
Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689

Query: 628  -----RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
                 R   EQ   +   ++ E  L+  +     L +  TS+ +  ++LE   SQ     
Sbjct: 1690 EIEELRATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747

Query: 683  EDI 685
            EDI
Sbjct: 1748 EDI 1750



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 60/296 (20%), Positives = 124/296 (41%), Gaps = 49/296 (16%)

Query: 361  NFNSQNGVNKDEKDHL----------------IER----LYREISGLKAQLENMKTE--- 397
            N+ +  G+ KD + HL                +ER    L  EI  L+A LE  +     
Sbjct: 1648 NYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI 1707

Query: 398  --------SQRVVLQLKGHVS------ELEADLAEQQ----HLRQQAADDCEFLRAELDE 439
                    S+RV L    + S      +LE D+++ Q     + Q+A +  E  +  + +
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767

Query: 440  LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMA 499
                 E+ +K Q + + +ER  +  EQ    L+ +  E  Q    L     ++ K  +  
Sbjct: 1768 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ--LALKGGKKQIQKLEARV 1825

Query: 500  RQAQVDLEREKKELEDSLERISDQGQR------KTQEQLEVLESLKQELATSQRELQVLQ 553
            R+ + ++E E+K   ++++ +    +R      +T+E  + +  L+  +   Q +++  +
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885

Query: 554  GSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609
               E + +      A+F +L+ E +     A   E +++ LR + ++   K+ S E
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 109/507 (21%), Positives = 217/507 (42%), Gaps = 64/507 (12%)

Query: 370  KDEKDHLIERLYR---EISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLR 423
            ++EK  L E+L +   EIS L++++E+ +    + Q+ + +L+  + ELE ++  ++  R
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135

Query: 424  QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
             +A      L  EL+E+  + E+   A  +  E+ +K +A  Q+  +  E+ +   +  A
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195

Query: 484  DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRKTQEQL 532
              LRK      AE+ +Q+   ++ +  LE+EK E++  ++ ++       + +   ++  
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255

Query: 533  EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHRE 588
              LE    EL + + E Q L   L          + EF+    E+++LVS    G     
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315

Query: 589  EELSALRKELQD---TQLKLASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQVI 635
            +++  L+++L++    +  LA   +S    C L ++Q       +  L     KA  +V 
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375

Query: 636  Q-------DALNQLEE-----PPLISCAGSADHLLSTV----TSISSCIEQLEKSWSQYL 679
            Q       DA+ + EE       L     +A+  +  V     S+    ++L+      +
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435

Query: 680  ACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETL----AY 735
               E  +    ++          +A     C     E   S  EA +  G E      AY
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEA-RSLGTELFKIKNAY 1494

Query: 736  LASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQ-EELGDLVDKEMAATSAAI 794
              SL++  +L+  +    +N   +I  + E++   G  I + E++   V++E     AA+
Sbjct: 1495 EESLDQLETLKREN----KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550

Query: 795  ETATARIEEMLSKSRAGDTGVKLEVNE 821
            E A A +E    K       ++LE+N+
Sbjct: 1551 EEAEASLEHEEGKI----LRIQLELNQ 1573



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 98/462 (21%), Positives = 191/462 (41%), Gaps = 77/462 (16%)

Query: 240  VKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFL 299
            +KL FK+   L +   +       E+F K+KD   +S   +       +  L E     L
Sbjct: 836  MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895

Query: 300  RASALSEHISPV-----------VVIPAEASSPDSEPVLEKDDLMDMDASQQNLFD---- 344
            +  A +E ++             + + A+          E++   ++ A ++ L D    
Sbjct: 896  QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955

Query: 345  --NKFDDIFGSSFSSDPFNFNSQNGV-NKDEK----DHLIERLYREISGL----KAQLEN 393
                 DD+  +    +     ++N V N  E+    D  I +L +E   L    +  L++
Sbjct: 956  LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015

Query: 394  MKTESQRV------VLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRE-D 446
            ++ E  +V       ++L+  V +LE  L +++ LR            +L+  +R+ E D
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-----------DLERAKRKLEGD 1064

Query: 447  TEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD--------------LLRKNAEV 492
             + AQ S+ +IE + Q  +++  K + + S L     D              L  +  E+
Sbjct: 1065 LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL 1124

Query: 493  TKQVSMARQAQVDLEREKKELEDSLERISDQGQR---KTQEQLEVLESLKQELATSQREL 549
             +++   R ++   E+++ +L   LE IS++ +     T  Q+E+ +  + E    +R+L
Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1184

Query: 550  QVLQGSLE---TSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD------ 600
            +  + +L+   T+A      A   AEL ++ D+L       E+E S ++ E+ D      
Sbjct: 1185 E--EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242

Query: 601  TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQL 642
            T  K     E MC+  +DQ   L     K+ E+  Q  +N L
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSEL-----KSKEEEQQRLINDL 1279



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 95/516 (18%), Positives = 218/516 (42%), Gaps = 77/516 (14%)

Query: 377  IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
            +E+   ++ G   Q + ++ + +R   +L+G +   +  + + ++ +QQ  +  +    E
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE 1092

Query: 437  LDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492
            +  L+ + ED +    + Q+ + E++ + +  E+     +   ++  +  +DL R+  E+
Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152

Query: 493  TK-----------QVSMARQAQVDLEREKKELED----------SLERISDQGQRKTQEQ 531
            ++           Q+ M ++ + + ++ +++LE+          +L +       +  EQ
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212

Query: 532  LEVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587
            ++ L+ +KQ+L   + E+++    L  ++ET ++++ N       LE +   L S    +
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS----K 1268

Query: 588  EEELSALRKEL--QDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEP 645
            EEE   L  +L  Q  +L+  S E S     K+     L   ++A  Q I++   QLEE 
Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328

Query: 646  PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705
              I    +  H L +       + +      QY    E  + L  +++      +  +A 
Sbjct: 1329 --IKAKNALAHALQSSRHDCDLLRE------QYEEEQESKAELQRALS----KANTEVAQ 1376

Query: 706  GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGE 765
              T       +  + L EA K+  +     L + EE     NA   ++     +++   E
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQR----LQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432

Query: 766  ELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLS--KSRAGDTGVKLEVNE-- 821
            +L+   LD+++            A  AA++      +++L+  K +  +T  +LE ++  
Sbjct: 1433 DLM---LDVERTN----------AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE 1479

Query: 822  ---------RILGCCTSLMQAIQVLIVASKDLQREI 848
                     +I       +  ++ L   +K+LQ+EI
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEI 1515



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 136/675 (20%), Positives = 268/675 (39%), Gaps = 69/675 (10%)

Query: 372  EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHL-------RQ 424
            EK+ L  ++  E  GL A  E    +  +  +QL+  + E+     +++ +       ++
Sbjct: 889  EKNDLQLQVQAEAEGL-ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKR 947

Query: 425  QAADDCEFLRAELDELRRQREDTEK----AQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480
            +  D+C  L+ ++D+L       EK     +  +  +  +    ++  +KL ++   L +
Sbjct: 948  KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007

Query: 481  NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRK------- 527
             H   L        +V+   +A++ LE++  +LE SLE+        ++ +RK       
Sbjct: 1008 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067

Query: 528  TQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587
             QE +  +E+ KQ+L    ++ +    +L++  + E    A   +L+K+   L +     
Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE---QALGIQLQKKIKELQARIEEL 1124

Query: 588  EEELSALR-------KELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN 640
            EEE+ A R       K+  D   +L    E + +        + +  ++ AE   Q    
Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE--FQKMRR 1182

Query: 641  QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS 700
             LEE  L   A +A        S++   EQ++          ++ S +   I        
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI-------- 1234

Query: 701  DAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKI 760
            D +A    T  +A      +L + C+    + L+ L S EEE      D TA R  L   
Sbjct: 1235 DDLASNVETVSKA----KGNLEKMCRTL-EDQLSELKSKEEEQQRLINDLTAQRGRLQ-- 1287

Query: 761  KAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN 820
               GE    R LD K+  +  L   + A T   IE    ++EE +    A    ++   +
Sbjct: 1288 TESGE--FSRQLDEKEALVSQLSRGKQAFTQ-QIEELKRQLEEEIKAKNALAHALQSSRH 1344

Query: 821  ERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNS-RWTEGLISASKAV 879
            +     C  L +  +    +  +LQR + ++    A  +  Y  ++ + TE L  A K +
Sbjct: 1345 D-----CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399

Query: 880  G---WGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQ-L 935
                  A   V+A +       K ++ +    E      +   A+    DK   N  + L
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459

Query: 936  QQASRGVNQATAGVVASTISGKS---QIEETDNMDFSSM-TLTQIKRQEMDSQVRVLELE 991
             +  +   +  A + AS    +S   ++ +  N    S+  L  +KR+  + Q  + +L 
Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1519

Query: 992  NELQKERQKLGELRK 1006
             ++ +  +++ EL K
Sbjct: 1520 EQIAEGGKRIHELEK 1534



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 68/284 (23%), Positives = 129/284 (45%), Gaps = 42/284 (14%)

Query: 388  KAQLENMKTESQRVVLQLKGHVSELEADLAEQQH----LRQQAADDCEFLRAELDELRRQ 443
            +A LE+ + +  R+ L+L    SE++  +AE+      L++      E +++ LD   R 
Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS 1613

Query: 444  REDT----EKAQRSLSEIE-------RKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492
            R D     +K +  L+E+E       R A    + Y   +    +   +  D LR   ++
Sbjct: 1614 RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673

Query: 493  TKQVSMARQAQVDLEREKKELEDSLE------RISDQGQRKTQEQLEVLESLKQELATSQ 546
             +Q++M  +    L+ E +EL  +LE      +I++Q      E++++L +    L  ++
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1733

Query: 547  RELQV----LQGSLETSAQSEANWAAEFA------------ELEKERDSLVSGAAHREEE 590
            ++L+     +QG +E   Q EA  A E A            EL+KE+D+    +AH E  
Sbjct: 1734 KKLETDISQMQGEMEDILQ-EARNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERM 1788

Query: 591  LSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQV 634
               + + ++D QL+L   E+   +  K Q + L    R+   +V
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1832



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 120/668 (17%), Positives = 260/668 (38%), Gaps = 89/668 (13%)

Query: 410  SELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYS 469
            +E E ++A  +   Q+  D+     A+  EL  +     K +   ++++ + QA  +  +
Sbjct: 849  AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK---NDLQLQVQAEAEGLA 905

Query: 470  KLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQ 529
              +E+  +L++    L  K  EVT++     +   +L  +K++LED    +         
Sbjct: 906  DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD------ 959

Query: 530  EQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREE 589
                 ++ L+  LA  ++E    +  ++   +  A      A+L KE+ +L        +
Sbjct: 960  -----IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014

Query: 590  ELSA------------LRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637
            +L A            ++ E Q   L+ +  +E   ++  ++ K  L G  K A++ I D
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074

Query: 638  ALNQLE--EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695
              N+ +  +  L        +L S +    +   QL+K   +  A  E++   +      
Sbjct: 1075 IENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE----- 1129

Query: 696  AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLE-------------EE 742
            A   S A A    + L       + ++E  ++ G  T A +   +             EE
Sbjct: 1130 AERASRAKAEKQRSDL---SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186

Query: 743  GSL--ENADSTAMRNCLSKIKAIGEEL-----LPRGLDIKQEELGDLVDKEMAATSAAIE 795
             +L  E   +T  +     +  +GE++     + + L+ ++ E+   +D ++A+    + 
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-DLASNVETVS 1245

Query: 796  TATARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES-- 851
             A   +E+M    + +  +   K E  +R++   T+    +Q     S +  R++ E   
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ---TESGEFSRQLDEKEA 1302

Query: 852  -----GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVC 906
                  RG  +  +   +  R  E  I A  A+           DL+   R ++EE    
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL---REQYEEEQES 1359

Query: 907  SHEIAASTAQL---VAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
              E+  + ++    VA  + K + D+     +L++A +         +A  +    +  E
Sbjct: 1360 KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVE 1411

Query: 963  TDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022
              N   +S+  T   +Q + ++V  L L  ++++       L KK      +   W++  
Sbjct: 1412 AVNAKCASLEKT---KQRLQNEVEDLML--DVERTNAACAALDKKQRNFDKILAEWKQKC 1466

Query: 1023 EASPPTLQ 1030
            E +   L+
Sbjct: 1467 EETHAELE 1474



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 75/363 (20%), Positives = 153/363 (42%), Gaps = 52/363 (14%)

Query: 370  KDEKDHLIERLY---REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426
            ++ K  L +RL      +  + A+  +++   QR+  +++  + ++E   A    L ++ 
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452

Query: 427  ADDCEFL---RAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELV 479
             +  + L   + + +E   + E ++K  RSL     +I+   + +  +   LK +   L 
Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQ 1512

Query: 480  QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE--------------------- 518
            Q  +DL  + AE  K++    + +  +E+EK EL+ +LE                     
Sbjct: 1513 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELN 1572

Query: 519  RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFA 571
            ++  +  RK  E+ E ++ LK+      R ++ +Q +L+   +S       +     +  
Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKR---NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629

Query: 572  ELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLAKDQRKMLLVGS 627
            E+E + +     AA         +  L+DTQ+     L S E+   QLA  +R+  L+ +
Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689

Query: 628  -----RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
                 R   EQ   +   ++ E  L+  +     L +  TS+ +  ++LE   SQ     
Sbjct: 1690 EIEELRATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747

Query: 683  EDI 685
            EDI
Sbjct: 1748 EDI 1750



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 60/296 (20%), Positives = 124/296 (41%), Gaps = 49/296 (16%)

Query: 361  NFNSQNGVNKDEKDHL----------------IER----LYREISGLKAQLENMKTE--- 397
            N+ +  G+ KD + HL                +ER    L  EI  L+A LE  +     
Sbjct: 1648 NYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI 1707

Query: 398  --------SQRVVLQLKGHVS------ELEADLAEQQ----HLRQQAADDCEFLRAELDE 439
                    S+RV L    + S      +LE D+++ Q     + Q+A +  E  +  + +
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767

Query: 440  LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMA 499
                 E+ +K Q + + +ER  +  EQ    L+ +  E  Q    L     ++ K  +  
Sbjct: 1768 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ--LALKGGKKQIQKLEARV 1825

Query: 500  RQAQVDLEREKKELEDSLERISDQGQR------KTQEQLEVLESLKQELATSQRELQVLQ 553
            R+ + ++E E+K   ++++ +    +R      +T+E  + +  L+  +   Q +++  +
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885

Query: 554  GSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609
               E + +      A+F +L+ E +     A   E +++ LR + ++   K+ S E
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 148/715 (20%), Positives = 288/715 (40%), Gaps = 106/715 (14%)

Query: 369  NKDEKDHLIERLYREISGLK------AQLENMKTESQRVVLQLKGHVSELEADLAEQQHL 422
            N D     +  ++ +I  LK      AQ  N    S   V  L    S+L  ++AE Q  
Sbjct: 570  NDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQ 629

Query: 423  -------RQQAADDCEFLRAELDELRRQR----EDTEKAQRSLSEIERKAQAN------- 464
                   +Q   ++ E +RA L+ELR Q     E+    Q+ L E E + + N       
Sbjct: 630  LQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQV 689

Query: 465  ----EQRYSKLKEKYSELVQNHADL-------LRKNAEVTKQVSMARQAQVDLEREKKEL 513
                EQ  +++++   +L + H +L        R+   + +++  A+Q   DL   K+E 
Sbjct: 690  KMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ 749

Query: 514  EDSL---------------ERIS--DQGQRKTQEQLEV-LESLKQELATSQRELQVLQGS 555
            ED L               E +S  DQ   K +EQ +  L++L++ +  + + ++VL   
Sbjct: 750  EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR 809

Query: 556  LETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQL 615
              TS Q +A        L++E + L   +   E  ++ L+++++D +   A  +E++ + 
Sbjct: 810  SNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKY 869

Query: 616  AKDQRKM--LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673
              + R++   LV +RK  ++ +  +  +  E  L +  G+          +S  +++  +
Sbjct: 870  EGEIRQLEEALVHARKEEKEAV--SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESE 927

Query: 674  SWSQYLACPEDISG----LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYG 729
               Q      ++      L  +I  L    +D +    T+ L    E  + L E  K+  
Sbjct: 928  QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTL----ELQNQLDE-YKEKN 982

Query: 730  RETLAYLASLEEEGSLENADS--TAMRNCLSKIKAIGEEL--LPRGLD-------IKQEE 778
            R  LA +    +E +LE   S  TAM+    +++ + EEL    R  D       + ++ 
Sbjct: 983  RRELAEMQRQLKEKTLEAEKSRLTAMK-MQDEMRLMEEELRDYQRAQDEALTKRQLLEQT 1041

Query: 779  LGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLI 838
            L DL + E+ A S   +  +  +++M  K    +  ++ E N   L     L + I    
Sbjct: 1042 LKDL-EYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDL-----LSERISRSR 1095

Query: 839  VASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG 898
               + L+ E+++        +       R  + L   S+ +    +       LVVQ   
Sbjct: 1096 EQMEQLRNELLQERAARQDLECDKISLERQNKDL--KSRIIHLEGSYRSSKEGLVVQMEA 1153

Query: 899  KFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958
            +  EL                  + + + +  + A LQ ++R + +    +V        
Sbjct: 1154 RIAEL------------------EDRLESEERDRANLQLSNRRLERKVKELVMQV--DDE 1193

Query: 959  QIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAG 1013
             +  TD  D  S+ L  +KRQ  +++  +  LE+  +K +++L E    +  L G
Sbjct: 1194 HLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQG 1248



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 63/276 (22%), Positives = 121/276 (43%), Gaps = 33/276 (11%)

Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENM------KTESQRVVLQLKGHVSEL--EAD 415
           SQ+    +E   L +RL      L+  LE +      + + Q  +  L+  +SE+  E D
Sbjct: 656 SQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELD 715

Query: 416 LAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY 475
            A++   R++ A         ++EL + ++D +    +  E E   +  E+  + LK   
Sbjct: 716 SAKRSEDREKGA--------LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGAL 767

Query: 476 SELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVL 535
            E V +H   + K  E       A +  V+   +  E+  S    S+Q Q  T+ ++++L
Sbjct: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827

Query: 536 -----------ESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGA 584
                      E L++ +A  QR+++ L+G    + ++   +  E  +LE   ++LV   
Sbjct: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE---EALVHAR 884

Query: 585 AHREEELS---ALRKELQDTQLKLASTEESMCQLAK 617
              +E +S   AL  EL+  Q  L+ T +   QL++
Sbjct: 885 KEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSE 920



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 111/551 (20%), Positives = 212/551 (38%), Gaps = 76/551 (13%)

Query: 317  EASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHL 376
            E SS D E    K+     DA  Q L ++  +        +   N + Q+    + +  L
Sbjct: 770  EVSSHDQEMDKLKEQY---DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKL 826

Query: 377  IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
            ++    ++ G   +LE    + QR +  LKG       D A+ +   ++   +   L   
Sbjct: 827  LQEENEKLQGRSEELERRVAQLQRQIEDLKG-------DEAKAKETLKKYEGEIRQLEEA 879

Query: 437  LDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQV 496
            L   R++ ++   A+R+L      AQ N           S+  Q    L  K  E ++Q 
Sbjct: 880  LVHARKEEKEAVSARRALENELEAAQGN----------LSQTTQEQKQLSEKLKEESEQK 929

Query: 497  SMARQAQVDLEREKKELEDSLERI----SDQGQRKTQEQLEVLESLKQELATSQRELQVL 552
               R+ + ++E E+  L  ++E++    +D  +      LE+   L +    ++REL  +
Sbjct: 930  EQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEM 989

Query: 553  QGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD---TQLKLASTE 609
            Q  L+               LE E+  L   A   ++E+  + +EL+D    Q +  +  
Sbjct: 990  QRQLKEKT------------LEAEKSRLT--AMKMQDEMRLMEEELRDYQRAQDEALTKR 1035

Query: 610  ESMCQLAKD-----QRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSI 664
            + + Q  KD     + K  L   R    + ++D ++QL E  L     ++D L   ++  
Sbjct: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQL-EMELEEERNNSDLLSERISRS 1094

Query: 665  SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEA 724
               +EQL     Q  A  +D+     S+          I H                 E 
Sbjct: 1095 REQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIH----------------LEG 1138

Query: 725  CKQYGRETL-----AYLASLEEEGSLENADSTAM----RNCLSKIKAIGEELLPRGLDIK 775
              +  +E L     A +A LE+    E  D   +    R    K+K +  ++    L + 
Sbjct: 1139 SYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT 1198

Query: 776  QEELGDLVDKEMAATSAAIETATARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQA 833
             ++  D +   + A    +E A   I+ + S  K    +   ++++NE + G   S+ + 
Sbjct: 1199 DQK--DQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKD 1256

Query: 834  IQVLIVASKDL 844
            +++  + SK L
Sbjct: 1257 LRLKKLPSKVL 1267


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 116/529 (21%), Positives = 228/529 (43%), Gaps = 68/529 (12%)

Query: 370  KDEKDHLIERLYR---EISGLKAQLENMKTES---QRVVLQLKGHVSELEADLAEQQHLR 423
            +++K  + E+L +   E+S L+A++++ +  S   Q+ + +L+  + ELE ++  +  LR
Sbjct: 1074 ENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR 1133

Query: 424  QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
             +       L  EL+E+  + E+   A  +  E+ +K +A  Q+  +  E+ +   +  A
Sbjct: 1134 AKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193

Query: 484  DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERISD--QGQRKTQEQLE--- 533
              LRK      AE+ +Q+   ++ +  LE+EK EL+  ++ ++   +   K++  +E   
Sbjct: 1194 ATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTC 1253

Query: 534  --VLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEEL 591
              V +   +  A  +++ Q++       A+ +     E +   +E++SL+S     ++ L
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQ-NGELSHRVEEKESLISQLTKSKQAL 1312

Query: 592  SALRKEL-----QDTQLKLA-----STEESMCQLAKDQ-------RKMLLVGSRKAAEQV 634
            +   +EL     ++T+ K A      +    C L ++Q       +  L     KA  +V
Sbjct: 1313 TQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372

Query: 635  IQ-------DALNQLEE-----PPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
             Q       DA+ + EE       L      A+   +T T+ S C   LEK+  +     
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE--NTETANSKC-ASLEKTKQRLQGEV 1429

Query: 683  EDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEE 742
            ED+   L              +H A   L       D +    KQ   E+ A L + ++E
Sbjct: 1430 EDLMRDLER------------SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477

Query: 743  GSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIE 802
                + +   MRN   ++    E L     ++ QEE+ DL + ++A T   ++ A     
Sbjct: 1478 SRSLSTELFKMRNAYEEVVDQLETLRRENKNL-QEEISDLTE-QIAETGKNLQEAEK--T 1533

Query: 803  EMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQV-LIVASKDLQREIVE 850
            + L +    D  V LE  E  L    S +  +Q+ L     +L R+++E
Sbjct: 1534 KKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIE 1582



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 141/690 (20%), Positives = 271/690 (39%), Gaps = 87/690 (12%)

Query: 383  EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQ----QHLRQQAADDCEFLRAELD 438
            E   ++  LE    + +     L+   ++  A+L EQ    Q ++Q+   +   L+ E+D
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233

Query: 439  ELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ-------NHADLLRKNAE 491
            ++     + E   +S S IER  +  E ++S++K K  +  Q         A L  +N E
Sbjct: 1234 DMA---SNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGE 1290

Query: 492  VTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQV 551
            ++ +V         L + K+ L   LE +    +R+ +E+ +   ++   L +S+ +  +
Sbjct: 1291 LSHRVEEKESLISQLTKSKQALTQQLEEL----KRQMEEETKAKNAMAHALQSSRHDCDL 1346

Query: 552  LQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHREEELSALRKEL-QDTQLKLA 606
            L+   E   +++A      ++   E    R    + A  R EEL   +K+L Q  Q    
Sbjct: 1347 LREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1406

Query: 607  STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISS 666
            +TE +  + A  ++      +++  +  ++D +  LE     +CA       +    ++ 
Sbjct: 1407 NTETANSKCASLEK------TKQRLQGEVEDLMRDLERSHT-ACATLDKKQRNFDKVLAE 1459

Query: 667  CIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAP----PEPADSLT 722
              ++L++S ++  A  ++   L   +  + +   + +    T  LR       E    LT
Sbjct: 1460 WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET--LRRENKNLQEEISDLT 1517

Query: 723  EACKQYGR--------------ETLAYLASLEE-EGSLENADSTAMRNCLSKIKAIGEEL 767
            E   + G+              E      +LEE EGSLE+ +S  +R  L   +   E  
Sbjct: 1518 EQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSE-- 1575

Query: 768  LPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-----LSKSRAGDTG---VKLEV 819
            L R +  K EE+  L      A  A      A I        L K   GD     ++L  
Sbjct: 1576 LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGH 1635

Query: 820  NERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYA----KNSRWTEGLISA 875
            + R +      ++ +Q  +   KD Q  + ++ R     KE  A    +N    E L   
Sbjct: 1636 SNRQMAETQKHLRTVQGQL---KDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692

Query: 876  SKAVGWGATV-------MVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAA-------- 920
              A+             ++DA+D V     +   L+    ++ A  AQ  A         
Sbjct: 1693 KVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQES 1752

Query: 921  --SKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNM--DFSSMTLTQI 976
              ++ KA K   + A + +  +     +A +     + +  +++  +   +   + L   
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1812

Query: 977  KRQEMDSQVRVLELENELQKERQKLGELRK 1006
            K+Q    + RV ELENEL  E+++  E  K
Sbjct: 1813 KKQIQKLENRVRELENELDVEQKRGAEALK 1842



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 145/730 (19%), Positives = 287/730 (39%), Gaps = 132/730 (18%)

Query: 378  ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437
            E +  E+   K  LE+  +  +R +  L+  ++++E +    ++  +  +++   L   +
Sbjct: 934  EEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENI 993

Query: 438  DELRRQREDTEKA-QRSLSEIE-RKAQAN---------EQRYSKLKEKYSELVQNHADLL 486
             +L ++++  ++A Q++L +++  + + N         EQ+   L+    +  +  ADL 
Sbjct: 994  SKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLE 1053

Query: 487  RKNAEVTKQVSMARQAQVDLEREKKELEDSLE-----------RISD------QGQRKTQ 529
            R   ++   + M++++ +DLE +K+++E+ L+           +I D      Q Q+K +
Sbjct: 1054 RAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIK 1113

Query: 530  EQLEVLESLKQELATSQ--------------RELQVLQGSLE-----TSAQSEANWAAEF 570
            E    +E L++E+                  REL+ +   LE     TSAQ E N   E 
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKRE- 1172

Query: 571  AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKA 630
            AE +K R  L       E   + LRK+  D+  +L    +++ ++     K  L   +  
Sbjct: 1173 AEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRV-----KQKLEKEKSE 1227

Query: 631  AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLH 690
             +  I D  + +E             L  + ++I      +E  +S+  A  E  + L+H
Sbjct: 1228 LKMEIDDMASNIEA------------LSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275

Query: 691  SITL-LAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYL-ASLEEEGSLENA 748
             + +  A L +    +G  +      E   S     KQ   + L  L   +EEE   +NA
Sbjct: 1276 DLNMQKARLQTQ---NGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNA 1332

Query: 749  DSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL------VDKEMAATSAAIET-ATARI 801
             + A+++          +LL    + +QE   +L       + E+A      ET A  R 
Sbjct: 1333 MAHALQSSRHDC-----DLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387

Query: 802  EEM--LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTAS-- 857
            EE+    K  A       E  E     C SL +  Q L    +DL R++  S    A+  
Sbjct: 1388 EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLD 1447

Query: 858  --PKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTA 915
               + F    + W + L  +   +          +  + + R  +EE++           
Sbjct: 1448 KKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV----------- 1496

Query: 916  QLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEET-DNMDFSSMTLT 974
                            L  L++ ++ + +  + +         QI ET  N+  +  T  
Sbjct: 1497 --------------DQLETLRRENKNLQEEISDLT-------EQIAETGKNLQEAEKTKK 1535

Query: 975  QIKRQEMDSQVRVLELENELQKERQKL-----------GELRKKHYELAGVAEGWEEGTE 1023
             +++++ D QV + E+E  L+ E  K+            EL +K  E     E  +  ++
Sbjct: 1536 LVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ 1595

Query: 1024 ASPPTLQEVV 1033
             +   LQ V+
Sbjct: 1596 RAAEALQSVL 1605



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 114/679 (16%), Positives = 286/679 (42%), Gaps = 82/679 (12%)

Query: 377  IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
            +E+   ++ G   Q + ++ + +R   +L+G +   +  + + ++ +QQ  +  +    E
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090

Query: 437  LDELRRQREDTE-----------KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485
            L +L+ + +D +           + Q  + E+E + +A     +K++++ S+L +   ++
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI 1150

Query: 486  LRKNAE----VTKQVSMARQAQVDLEREKKELED----------SLERISDQGQRKTQEQ 531
              +  E     + Q+ M ++ + + ++ +++LE+          +L +       +  EQ
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ 1210

Query: 532  LEVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587
            ++ L+ +KQ+L   + EL++    +  ++E  ++S++N       +E +   + +    +
Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA----K 1266

Query: 588  EEELSALRKELQDTQLKLASTEESMCQLAKDQRKML--LVGSRKAAEQVIQDALNQLEEP 645
            +E+ + L  +L   + +L +    +    +++  ++  L  S++A  Q +++   Q+EE 
Sbjct: 1267 DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326

Query: 646  PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705
                   +  H L   +S   C + L + + +      ++   L          +  +A 
Sbjct: 1327 --TKAKNAMAHALQ--SSRHDC-DLLREQYEEEQEAKAELQRALSK-------ANSEVAQ 1374

Query: 706  GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGE 765
              T       +  + L EA K+  +     L   EE     N+   ++     +++   E
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQR----LQEAEENTETANSKCASLEKTKQRLQGEVE 1430

Query: 766  ELLPRGLDIKQEELGDL------VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV 819
            +L+ R L+        L       DK +A     ++ + A +E    +SR+  T +    
Sbjct: 1431 DLM-RDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMR 1489

Query: 820  N--ERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASK 877
            N  E ++    +L +  + L     DL  +I E+G+     ++        T+ L+   K
Sbjct: 1490 NAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK--------TKKLVEQEK 1541

Query: 878  AVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQ 937
            +        +  A   V+G  + EE  +   ++  S  +     KV  +KD   + QL++
Sbjct: 1542 S-------DLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKV-IEKDE-EIEQLKR 1592

Query: 938  ASRGVNQATAGVVASTISGKS---QIEETDNMDFSSM--TLTQIKRQEMDSQVRVLELEN 992
             S+   +A   V+ + I  ++   ++++    D + M   L    RQ  ++Q  +  ++ 
Sbjct: 1593 NSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG 1652

Query: 993  ELQKERQKLGELRKKHYEL 1011
            +L+  +  L +  + + +L
Sbjct: 1653 QLKDSQLHLDDALRSNEDL 1671



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 108/512 (21%), Positives = 204/512 (39%), Gaps = 74/512 (14%)

Query: 370  KDEKDHLIERLYREISGLKAQLENMKTES-QRVVLQLKGHVSELEADLAEQQHLRQQAAD 428
            ++ K  L +RL         +  N K  S ++   +L+G V +L  DL E+ H      D
Sbjct: 1391 EEAKKKLAQRLQEAEEN--TETANSKCASLEKTKQRLQGEVEDLMRDL-ERSHTACATLD 1447

Query: 429  DCEF--------LRAELDELRRQREDTEKAQRSLS-----------EIERKAQANEQRYS 469
              +          + +LDE + + E  +K  RSLS           E+  + +   +   
Sbjct: 1448 KKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENK 1507

Query: 470  KLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE----------- 518
             L+E+ S+L +  A+  +   E  K   +  Q + DL+   +E+E SLE           
Sbjct: 1508 NLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL 1567

Query: 519  ---RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAA 568
               ++  +  RK  E+ E +E LK+    SQR  + LQ  L+   +S       +     
Sbjct: 1568 ELSQVKSELDRKVIEKDEEIEQLKR---NSQRAAEALQSVLDAEIRSRNDALRLKKKMEG 1624

Query: 569  EFAELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLA-KDQRKML 623
            +  E+E +        A  ++ L  ++ +L+D+QL     L S E+   QLA  ++R  L
Sbjct: 1625 DLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGL 1684

Query: 624  LVGSRKAAEQVIQ--DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
            L+   +  +  ++  +   +L E  L+  +     L S  TS+ +  ++LE   +Q   C
Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQ---C 1741

Query: 682  PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSL-TEACKQYGRETLAYLASLE 740
              ++   +            AI   A        E   S   E  K+   +T+  L    
Sbjct: 1742 QAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL---- 1797

Query: 741  EEGSLENADSTAMRNCLSKIKAIGEEL--LPRGLDIKQEELGDLVD---------KEMAA 789
             +  L+ A+  A++    +I+ +   +  L   LD++Q+   + +          KEM  
Sbjct: 1798 -QHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTY 1856

Query: 790  TSAAIETATARIEEMLSKSRAGDTGVKLEVNE 821
             +        R+++++ K +A     K +  E
Sbjct: 1857 QAEEDHKNILRLQDLVDKLQAKVKSYKRQAEE 1888



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 54/249 (21%), Positives = 114/249 (45%), Gaps = 27/249 (10%)

Query: 382  REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
            +E++ +K   E  K E  R   + K    ++ + L E+  L+ Q       +++E + L 
Sbjct: 851  KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQ-------VQSETENLM 903

Query: 442  RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
               E  E   +S   +E K +   +R  + +E  SELV    +L  K + + + +     
Sbjct: 904  DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963

Query: 502  AQVDLEREKKELEDSLERISDQG-------QRKTQEQLEVLESLKQELATSQRELQVLQG 554
                +E+EK   E+ ++ +S++         + T+E+  + E+ +Q L   Q E   + G
Sbjct: 964  TLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNG 1023

Query: 555  SLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA-LRKELQDTQLKLASTEESMC 613
             ++ +           A+LE++ D L  G+  +E++L A L +  +  +  L  ++ES+ 
Sbjct: 1024 LIKIN-----------AKLEQQTDDL-EGSLEQEKKLRADLERAKRKLEGDLKMSQESIM 1071

Query: 614  QLAKDQRKM 622
             L  D++++
Sbjct: 1072 DLENDKQQI 1080


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 143/669 (21%), Positives = 266/669 (39%), Gaps = 75/669 (11%)

Query: 373  KDHLIER-LYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQ-QHLRQQAADDC 430
            KD L  R L  E+   K ++E      +R +  LKG + E  A   ++ +H+RQQ   D 
Sbjct: 467  KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526

Query: 431  EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
            E LR  + +  +     E  ++ +S + R  Q   +  S+    +  + Q + + LR   
Sbjct: 527  EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586

Query: 491  EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQ 550
            +   Q+ M ++   ++E E  E  + L+R  +Q +    +  +V E LK+EL  +Q EL+
Sbjct: 587  QELLQLRMEKE---EMEEELGEKIEVLQRELEQARASAGDTRQV-EVLKKELLRTQEELK 642

Query: 551  VLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDT--QLKLAST 608
             LQ   E  +Q  A    +  ELEK+  +++   A R  EL     +LQ T  QL+    
Sbjct: 643  ELQA--ERQSQEVAGRHRD-RELEKQL-AVLRVEADRGRELEEQNLQLQKTLQQLRQDCE 698

Query: 609  EESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLE---------EPPLISCAGSADHLLS 659
            E S  ++  +    +L   R A E  +++   + +         E  L    G  D   +
Sbjct: 699  EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEA 758

Query: 660  TVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPAD 719
                +   +++LE    Q                L A    +     A   L A  E A 
Sbjct: 759  VEARLRDKLQRLEAEKQQL------------EEALNASQEEEGSLAAAKRALEARLEEAQ 806

Query: 720  SLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEEL 779
                   + G+E      +LEEEG          R  L + KA  EE   R LD   + L
Sbjct: 807  ---RGLARLGQEQQTLNRALEEEGK--------QREVLRRGKAELEE-QKRLLDRTVDRL 854

Query: 780  GDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN------ERILGCCTSLMQA 833
               ++K    +  A++   A++E+   K+R      + +        E+  G  + L   
Sbjct: 855  NKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDE 914

Query: 834  IQVLIVASKDLQRE-----------------IVESGRGTASPKEFYAKNSRWTEGLISAS 876
            IQ L  A +  Q E                 + +        ++  A+  +  E  +S  
Sbjct: 915  IQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRL 974

Query: 877  KA-VGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQL 935
            +  +      +    D V +GR + ++L     +   S  Q +   K+  ++ + +L   
Sbjct: 975  ETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQ-ERSARQDLECDKISLERQNKDLKTR 1033

Query: 936  QQASRGVNQATAGVVASTISGKSQ-IEETDNMDFSSMTLTQIKRQEMDSQVRVLELENEL 994
              +S G  + +A +  S +  ++Q ++E    +    T+ Q   ++++ +V+  EL  ++
Sbjct: 1034 LASSEGFQKPSASL--SQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVK--ELSIQI 1089

Query: 995  QKERQKLGE 1003
            + ERQ + +
Sbjct: 1090 EDERQHVND 1098



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 56/219 (25%), Positives = 95/219 (43%), Gaps = 48/219 (21%)

Query: 378  ERLYREISGLKAQLENMKTESQRVVLQLKG---HVSELEADLAEQQHLRQ-------QAA 427
            E L + + GL+ + EN K        QLKG    VS LE +L E+++  +       +  
Sbjct: 937  ELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGR 996

Query: 428  DDCEFLRAELDELRRQREDTE------------------------KAQRSLSEIERKAQA 463
            D  + LR EL + R  R+D E                        K   SLS++E + Q 
Sbjct: 997  DQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056

Query: 464  NEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVD-----------LEREKKE 512
             ++R    + + + L   +  L RK  E++ Q+   RQ   D           L+R+  E
Sbjct: 1057 LQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDE 1116

Query: 513  LEDSLERISD---QGQRKTQEQLEVLESLKQELATSQRE 548
             E+ +ER+     + QR+ +EQ EV E L+  + + +++
Sbjct: 1117 AEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKD 1155



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 71/341 (20%), Positives = 136/341 (39%), Gaps = 28/341 (8%)

Query: 328 EKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGL 387
           E ++  +     Q++F    +D+  +    +      +    ++E    IE L RE+   
Sbjct: 560 ELEETSEETGHWQSMFQKNKEDLRATK--QELLQLRMEKEEMEEELGEKIEVLQRELEQA 617

Query: 388 KA------QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE-- 439
           +A      Q+E +K E  R   +LK   +E ++     +H  ++       LR E D   
Sbjct: 618 RASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGR 677

Query: 440 ------------LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
                       L++ R+D E+A ++    E +A    QR + ++    E  + + +  R
Sbjct: 678 ELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR 737

Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
           +   + +Q+   R      E  +  L D L+R+  + Q + +E L   +  +  LA ++R
Sbjct: 738 RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ-QLEEALNASQEEEGSLAAAKR 796

Query: 548 ELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603
            L+      Q  L    Q +        E  K+R+ L  G A  EE+   L + +     
Sbjct: 797 ALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNK 856

Query: 604 KLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
           +L    E   Q A  Q +  L   ++ A + + DA  Q ++
Sbjct: 857 ELEKIGEDSKQ-ALQQLQAQLEDYKEKARREVADAQRQAKD 896



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 138/672 (20%), Positives = 250/672 (37%), Gaps = 109/672 (16%)

Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDC 430
           DE+    ++L     GL+ QLE  KTE            S L+  L  ++   QQ+  + 
Sbjct: 376 DEEVKKRQKLEPSQVGLERQLEE-KTEE----------CSRLQELLERRKGEAQQSNKEL 424

Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
           + ++  LD+    R   E     L    +  Q  E     L +   E  +   ++L    
Sbjct: 425 QNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQ 484

Query: 491 EVTKQVSMARQAQVDLEREKKE----LEDSLERISDQGQRKTQEQLEVLESLKQELATSQ 546
            V +Q+ +  +    L+   KE     +  +E +  Q QR T++    ++   Q+ A  +
Sbjct: 485 RVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLE 544

Query: 547 RELQV-------LQGSLETSAQSEANWAAEF----AELEKERDSLVSGAAHRE------- 588
            E Q        LQ  LE +++   +W + F     +L   +  L+     +E       
Sbjct: 545 AERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG 604

Query: 589 EELSALRKELQDTQLKLAST---EESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEP 645
           E++  L++EL+  +     T   E    +L + Q ++  + + + +++V     ++  E 
Sbjct: 605 EKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEK 664

Query: 646 PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705
            L      AD        +     QL+K+  Q     E+ S       ++A   +  +  
Sbjct: 665 QLAVLRVEADR----GRELEEQNLQLQKTLQQLRQDCEEAS----KAKMVAEAEATVLGQ 716

Query: 706 ---GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLEN---ADSTAMRNCLSK 759
                 T LR   E  D       ++ R  L     L+E   L +   A    +R+ L +
Sbjct: 717 RRAAVETTLRETQEEND-------EFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR 769

Query: 760 IKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV 819
           ++A  ++ L   L+  QEE G L     AA   A+E   AR+EE  ++      G + + 
Sbjct: 770 LEA-EKQQLEEALNASQEEEGSL-----AAAKRALE---ARLEE--AQRGLARLGQEQQT 818

Query: 820 NERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAV 879
             R L                 +  QRE++   RG A  +E      R  + L    + +
Sbjct: 819 LNRAL---------------EEEGKQREVLR--RGKAELEEQKRLLDRTVDRLNKELEKI 861

Query: 880 GWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQ--- 936
           G       D+   + Q + + E+    +    A   +       +A+K S  L++LQ   
Sbjct: 862 G------EDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915

Query: 937 ----------QASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVR 986
                     QA R   +    ++A  + G  Q  E +N   S        RQ    + +
Sbjct: 916 QRLRQALQASQAERDTARLDKELLAQRLQGLEQ--EAENKKRSQ---DDRARQLKGLEEK 970

Query: 987 VLELENELQKER 998
           V  LE EL +E+
Sbjct: 971 VSRLETELDEEK 982



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 128/603 (21%), Positives = 224/603 (37%), Gaps = 94/603 (15%)

Query: 477  ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE 536
            EL +   +L RK  E  K+      +QV LER+ +E  +   R+            E+LE
Sbjct: 363  ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQ-----------ELLE 411

Query: 537  SLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRK 596
              K E   S +ELQ ++  L+           +  EL+ +   +      +E     L K
Sbjct: 412  RRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKE----VLLK 467

Query: 597  ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGS-AD 655
            +L +T               ++  + +L G ++  EQ+      +L E  L +  G+  +
Sbjct: 468  DLLET---------------RELLEEVLEGKQRVEEQL------RLRERELTALKGALKE 506

Query: 656  HLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPP 715
             + S    +    +Q ++   Q     +D +   H++         A+  G    L    
Sbjct: 507  EVASRDQEVEHVRQQYQRDTEQLRRSMQDAT-QDHAVLEAERQKMSALVRGLQRELEETS 565

Query: 716  EPA---DSLTEACKQYGRETLAYLASL-----EEEGSLENADSTAMRNCLSKIKAIGE-- 765
            E      S+ +  K+  R T   L  L     E E  L        R       + G+  
Sbjct: 566  EETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTR 625

Query: 766  --ELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRA-----GDTGVKLE 818
              E+L + L   QEEL     KE+ A   + E A    +  L K  A      D G +LE
Sbjct: 626  QVEVLKKELLRTQEEL-----KELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELE 680

Query: 819  VNERILGCCTSLMQAIQVLIVASKD---LQREIVESGRGTASP----KEFYAKNSRW--- 868
              E+ L    +L Q  Q    ASK     + E    G+  A+     +E   +N  +   
Sbjct: 681  --EQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRR 738

Query: 869  ----------TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLV 918
                      T GL+   +AV      + D    +   + + EE +  S E   S A   
Sbjct: 739  ILGLEQQLKETRGLVDGGEAV---EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK 795

Query: 919  AASKVKADKDSPNLAQLQQASRGVNQA--TAGVVASTI-SGKSQIEETDNM-----DFSS 970
             A + + ++    LA+L Q  + +N+A    G     +  GK+++EE   +     D  +
Sbjct: 796  RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN 855

Query: 971  MTLTQIKRQEMDS-QVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTL 1029
              L +I      + Q    +LE+  +K R+++ + +++  + A  AE    G       +
Sbjct: 856  KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915

Query: 1030 QEV 1032
            Q +
Sbjct: 916  QRL 918



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 76/348 (21%), Positives = 135/348 (38%), Gaps = 40/348 (11%)

Query: 145  LLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLE-CELNLFQTVF 203
            L R K E   +       +   +++L++ GE       QL  ++ DY E     +     
Sbjct: 833  LRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQR 892

Query: 204  NSLDMSRSVSVTAAGQCRLAPLIQVI---LDCSHLYDYTVKLLFKLHSCLPADTLQGHRD 260
             + D +     T+ G  RL   IQ +   L  S     T     +L   L A  LQG   
Sbjct: 893  QAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTA----RLDKELLAQRLQG--- 945

Query: 261  RFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASS 320
              +EQ  + K    RS +     R  Q+  L E        + L E  + V ++    + 
Sbjct: 946  --LEQEAENKK---RSQD----DRARQLKGLEEKVSRL--ETELDEEKNTVELLTDRVNR 994

Query: 321  PDSEPVLEKDDLMDMDASQQNLFDNKFD------DIFGSSFSSDPFNFNSQNGVNKDEKD 374
               +    + +LM   +++Q+L  +K        D+     SS+ F   S +    + ++
Sbjct: 995  GRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQN 1054

Query: 375  HLI-ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL 433
             L+ ERL  E        E  KT  Q    +L+  V EL   + ++   RQ   D  + L
Sbjct: 1055 QLLQERLQAE--------EREKTVLQSTNRKLERKVKELSIQIEDE---RQHVNDQKDQL 1103

Query: 434  RAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQN 481
               +  L+RQ ++ E+    L  + +KAQ   +   ++ E+    +++
Sbjct: 1104 SLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKS 1151


>gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens]
          Length = 284

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 74/297 (24%), Positives = 131/297 (44%), Gaps = 42/297 (14%)

Query: 326 VLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYR-EI 384
           +L+ D    +D ++Q   D K  +        D         V++DE+D ++E L++ E 
Sbjct: 10  MLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAED 69

Query: 385 SGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQR 444
           S L A+    K E+    L  +  + E E D A+++            L   L +L    
Sbjct: 70  SLLAAEEAAAKAEADVASLNRRIQLVEEELDRAQER------------LATALQKLEEAE 117

Query: 445 EDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQV 504
           +  ++++R +  IE +AQ +E++    + +  E      D  RK  EV +++ +      
Sbjct: 118 KAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIES--- 174

Query: 505 DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQ-----------RELQVLQ 553
           DLER ++  E     +S+   R+ +EQL +++   + L  ++            E++VL 
Sbjct: 175 DLERAEERAE-----LSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLS 229

Query: 554 GSLETSAQSEANWAAEFAE-----LEKERDSLVSGAAHREEELSALRKELQDTQLKL 605
             L+     EA   AEFAE     LEK  D L    AH +EE  ++ + L  T L+L
Sbjct: 230 DKLK-----EAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLEL 281


>gi|4504063 golgin 97 [Homo sapiens]
          Length = 767

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 129/601 (21%), Positives = 244/601 (40%), Gaps = 86/601 (14%)

Query: 483  ADLLRKNAEVTK---QVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLK 539
            + LLR+N ++ K   ++S   +   +L++ K++LE +LE+  D   RK QEQ E  ++ +
Sbjct: 58   SQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANR 117

Query: 540  QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----------GAAHREE 589
             ++A         +G     A+ +  W+ +  +LEKE++ L +              R +
Sbjct: 118  AKMA---------EGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRD 168

Query: 590  ELSAL----RKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAE-----QVIQDALN 640
            E+  L    ++EL   +  L   EES+ ++ ++        SR   E     Q+  D   
Sbjct: 169  EMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQ 228

Query: 641  QLEEPP--LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698
            +LEE      +     DH++++ T   S I  LE+   +  A  + +S  L  +T     
Sbjct: 229  KLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQE 288

Query: 699  TSDAIAH--GATTCLRAPPEPADSLTEACKQYGRE-TLA----------YLASLEEEGSL 745
              D I H       L    E   S  E  ++  +E TLA           LA+   +   
Sbjct: 289  KEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKA 348

Query: 746  ENADSTAMRNCLSKIKAIGEELLP-RGLDIKQE-----------ELGDLVDKEMAATSAA 793
             N   T +R     ++A  E+L   +G+   QE           E   +  + +A     
Sbjct: 349  INTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQF 408

Query: 794  IETATARIEEM--LSKSRAGDT-----GVKL--EVNERILGCCTSLMQAIQVLIVASKDL 844
            +E   A   ++  L ++RA D      G++   + N  +  C     +++Q      K L
Sbjct: 409  LERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKL 468

Query: 845  -----QREIVESGRGTA------SPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLV 893
                 QREIV      A        +EF  + +  T  +    + +     V++     +
Sbjct: 469  KEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEI 528

Query: 894  VQGRGKFEELMVCSHEIAAS-----TAQLVAASKVKADKDSPNL-AQLQQASRGVNQA-- 945
            +Q        ++  H++ A      T +   A+ V   +D   L   LQ  +  VN++  
Sbjct: 529  LQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHV 588

Query: 946  TAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELR 1005
            T+  +   +        T N +  +M LTQ+++++ D + ++LE    +++ +Q++ ELR
Sbjct: 589  TSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELR 648

Query: 1006 K 1006
            K
Sbjct: 649  K 649



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 57/220 (25%), Positives = 103/220 (46%), Gaps = 26/220 (11%)

Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAA-------DD 429
           +E   RE+       E    +S+ +V   +  + EL A   E  H++QQA        + 
Sbjct: 352 LETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLER 411

Query: 430 CEFLRAELDELRRQRE-DTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRK 488
            + L A++  L R R  D   A++ + ++E++  A ++     + +Y   +QNH   L+K
Sbjct: 412 TQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKE----CRNEYERSLQNHQFELKK 467

Query: 489 NAEVTKQ---VSMA-RQAQVDLEREKKELED---SLERISDQGQRKTQEQLEVLESLKQE 541
             E   Q   VS+A  QA  ++ ++++E +    +L  I D+ ++  +E+ EVL   +QE
Sbjct: 468 LKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQE 527

Query: 542 LATSQR-------ELQVLQGSLETSAQSEANWAAEFAELE 574
           +   +R       ++  LQ  LE     +A  AA  AE E
Sbjct: 528 ILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQE 567



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 69/319 (21%), Positives = 136/319 (42%), Gaps = 22/319 (6%)

Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
           +DE D L     +E+S +K  L   +    ++  +L+    EL     E  +  Q ++D 
Sbjct: 167 RDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSD- 225

Query: 430 CEFLRAELDELRRQREDTEKAQ----RSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485
              L  +L+EL+R     E+ +     S +  E K  A EQ+  +L+    +L     DL
Sbjct: 226 ---LSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQL---SIDL 279

Query: 486 LRKNAEVTKQVSMARQAQVDLEREKKELEDSL---ERISDQGQRKTQEQLEVLESLKQEL 542
            +  AE  ++  +    Q  +   +K LE +L   E + +  + KT  + + LE  +Q+L
Sbjct: 280 QKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAE-QNLEDTRQQL 338

Query: 543 ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ 602
             ++        +LET  +          E  ++   +V+    + +EL+A  +E    Q
Sbjct: 339 LAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQ 398

Query: 603 LKLASTEESMCQ--LAKDQRKMLLVGSRKAAEQVIQDALNQLEE--PPLISCAGSADHLL 658
            +  + E+   +   A + + + L  +R A +   +  + QLE+    L  C    +  L
Sbjct: 399 QQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSL 458

Query: 659 STVTSISSCIEQLEKSWSQ 677
               +    +++L++ WSQ
Sbjct: 459 Q---NHQFELKKLKEEWSQ 474



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 53/266 (19%), Positives = 114/266 (42%), Gaps = 17/266 (6%)

Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEA----DLAEQQHLRQQA 426
           ++K+  ++ L +++S    ++     E + V+  L+  V+ LE     +L+ ++H+ Q+ 
Sbjct: 262 EQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHV-QEL 320

Query: 427 ADDCEFLRAELDELRRQ----REDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSEL 478
             +       L++ R+Q    R    KA  +L     E+E+  QA+E++  + K     +
Sbjct: 321 LKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKG----I 376

Query: 479 VQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538
           V      +++ A   ++ S  +Q  + LE++  E   +LE      +R         E  
Sbjct: 377 VAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQG 436

Query: 539 KQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKEL 598
            ++L      L+  +   E S Q+      +  E   +R+ +    A   EE+   R+E 
Sbjct: 437 MRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEF 496

Query: 599 QDTQLKLASTEESMCQLAKDQRKMLL 624
           Q     L +  +   Q  +++ ++LL
Sbjct: 497 QQQAANLTAIIDEKEQNLREKTEVLL 522



 Score = 35.4 bits (80), Expect = 0.28
 Identities = 40/201 (19%), Positives = 83/201 (41%), Gaps = 41/201 (20%)

Query: 382 REISGLKAQLENMKTE-SQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDEL 440
           R +   + +L+ +K E SQR ++ +      LE    +++  +QQAA+    +  +   L
Sbjct: 456 RSLQNHQFELKKLKEEWSQREIVSV-AMAQALEEVRKQREEFQQQAANLTAIIDEKEQNL 514

Query: 441 RRQREDTEKAQRSLSEIER----------KAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
           R + E   + ++ + ++ER          + QA  +    LK + + +V    DLLR   
Sbjct: 515 REKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRG 574

Query: 491 EVTKQVSMARQAQV-----------------------------DLEREKKELEDSLERIS 521
            +  +     ++ V                              L++EK++LE  L   +
Sbjct: 575 PLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKN 634

Query: 522 DQGQRKTQEQLEVLESLKQEL 542
              ++  Q  LE+ ++L++EL
Sbjct: 635 KTIKQMQQRMLELRKTLQKEL 655


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 140/688 (20%), Positives = 277/688 (40%), Gaps = 89/688 (12%)

Query: 383  EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQ----QHLRQQAADDCEFLRAELD 438
            E   ++  LE    + +     L+   ++  A+L EQ    Q ++Q+   +    + ELD
Sbjct: 1170 EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD 1229

Query: 439  ELRRQREDTEKAQRSLSEIER--KAQANEQRYSKLKE---KYSELVQNHADLLRKNAEVT 493
            ++    E   KA+ +L ++ R  + Q NE R SK +E     ++L    A L  +N E++
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHR-SKAEETQRSVNDLTSQRAKLQTENGELS 1288

Query: 494  KQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQ 553
            +Q+         L R K      LE +    +R+ +E+++   +L   L +++ +  +L+
Sbjct: 1289 RQLDEKEALISQLTRGKLTYTQQLEDL----KRQLEEEVKAKNALAHALQSARHDCDLLR 1344

Query: 554  GSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHREEELSALRKELQDTQLKLASTE 609
               E   +++A      ++   E    R    + A  R EEL   +K+L     +L   E
Sbjct: 1345 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ---RLQEAE 1401

Query: 610  ESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSI-SSCI 668
            E++   A + +   L  ++   +  I+D +  +E     + A + D        I +   
Sbjct: 1402 EAV--EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN--AAAAALDKKQRNFDKILAEWK 1457

Query: 669  EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH----------------GATTCLR 712
            ++ E+S S+  +  ++   L   +  L +   +++ H                  T  L 
Sbjct: 1458 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517

Query: 713  APPEPADSLTEACKQYGRETLAYLASLEE-EGSLENADSTAMRNCL--SKIKA-IGEELL 768
            +  +    L +  KQ   E +   ++LEE E SLE+ +   +R  L  ++IKA I  +L 
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1577

Query: 769  PRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTG---VKLEVNERILG 825
             +  +++Q +   L   +   TS   ET +      + K   GD     ++L    R+  
Sbjct: 1578 EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAA 1637

Query: 826  CCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATV 885
                 ++++Q L+   KD Q ++ ++ R     KE  A   R    L+ A          
Sbjct: 1638 EAQKQVKSLQSLL---KDTQIQLDDAVRANDDLKENIAIVER-RNNLLQAELEELRAVVE 1693

Query: 886  MVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQ--------Q 937
              + +  + +     +EL+  S  +    +Q  +    K   D+ +L+QLQ        +
Sbjct: 1694 QTERSRKLAE-----QELIETSERVQLLHSQNTSLINQKKKMDA-DLSQLQTEVEEAVQE 1747

Query: 938  ASRGVNQATAGVVASTISGKSQIEETD----------NMDFS------------SMTLTQ 975
                  +A   +  + +  +   +E D          NM+ +             + L  
Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1807

Query: 976  IKRQEMDSQVRVLELENELQKERQKLGE 1003
             K+Q    + RV ELENEL+ E+++  E
Sbjct: 1808 GKKQLQKLEARVRELENELEAEQKRNAE 1835



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 104/509 (20%), Positives = 214/509 (42%), Gaps = 68/509 (13%)

Query: 370  KDEKDHLIERLYR---EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLR 423
            +++K  L ERL +   E++ L A++E+   + ++ Q+ + +L+  + ELE +L  ++  R
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129

Query: 424  QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
             +       L  EL+E+  + E+   A     E+ +K +A  Q+  +  E+ +   +  A
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1189

Query: 484  DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR--KTQEQLE-VL 535
              LRK      AE+ +Q+   ++ +  LE+EK E +  L+ ++   ++  K +  LE + 
Sbjct: 1190 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMC 1249

Query: 536  ESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEK---ERDSLVS----GAAHRE 588
             +L+ ++   + + +  Q S+       A    E  EL +   E+++L+S    G     
Sbjct: 1250 RTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT 1309

Query: 589  EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLI 648
            ++L  L+++L++ ++K  +      Q A+    +L        EQ  ++   + E   ++
Sbjct: 1310 QQLEDLKRQLEE-EVKAKNALAHALQSARHDCDLL-------REQYEEETEAKAELQRVL 1361

Query: 649  SCAGSADHLLSTVTSISSC-----IEQLEKSWSQYLACPED----ISGLLHSITLLAHLT 699
            S A S      T     +      +E+ +K  +Q L   E+    ++    S+    H  
Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRL 1421

Query: 700  SDAI---------AHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEG------- 743
             + I         ++ A   L       D +    KQ   E+ + L S ++E        
Sbjct: 1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481

Query: 744  -SLENADSTAM----------RNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSA 792
              L+NA   ++          +N   +I  + E+L   G  I + E    V K++ A   
Sbjct: 1482 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE---KVRKQLEAEKM 1538

Query: 793  AIETATARIEEMLSKSRAGDTGVKLEVNE 821
             +++A    E  L          +LE N+
Sbjct: 1539 ELQSALEEAEASLEHEEGKILRAQLEFNQ 1567



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 121/565 (21%), Positives = 232/565 (41%), Gaps = 72/565 (12%)

Query: 240  VKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFL 299
            +KL FK+   L +   +       E+FT+LK+   +S   +       +  L E     L
Sbjct: 830  MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL 889

Query: 300  RASALSEHISPVV---------VIPAEASSPDSEPVLEKDDLM--DMDASQQNLFD---- 344
            +  A  ++++             I  EA   +    LE ++ M  ++ A ++ L D    
Sbjct: 890  QVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 949

Query: 345  --NKFDDIFGSSFSSDPFNFNSQNGV-NKDEK----DHLIERLYREISGL----KAQLEN 393
                 DD+  +    +     ++N V N  E+    D +I +L +E   L    +  L++
Sbjct: 950  LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1009

Query: 394  MKTESQRV------VLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDT 447
            ++ E  +V       ++L+  V +LE  L +++ +R         L  +L   +    D 
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069

Query: 448  EKAQRSLSEIERK----AQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ 503
            E  ++ L E  +K      A   R    +   S+L +   +L  +  E+ +++   R A+
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129

Query: 504  VDLEREKKELEDSLERISDQGQR---KTQEQLEVLESLKQELATSQRELQVLQGSLE--- 557
              +E+ + +L   LE IS++ +     T  Q+E+ +  + E    +R+L+  + +L+   
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE--EATLQHEA 1187

Query: 558  TSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ------LKLASTEES 611
            T+A      A   AEL ++ D+L       E+E S  + EL D        +K  +  E 
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK 1247

Query: 612  MCQLAKDQRKMLLVGSRKAAEQVIQDALNQL--EEPPLISCAGSADHLLSTVTSISSCIE 669
            MC+  +DQ     +   ++  +  Q ++N L  +   L +  G     L    ++ S + 
Sbjct: 1248 MCRTLEDQ-----MNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1302

Query: 670  QLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYG 729
            + + +++Q L   ED+   L           +A+AH     L++     D L E   QY 
Sbjct: 1303 RGKLTYTQQL---EDLKRQLEEEV----KAKNALAH----ALQSARHDCDLLRE---QYE 1348

Query: 730  RETLAYLASLEEEGSLENADSTAMR 754
             ET A  A L+   S  N++    R
Sbjct: 1349 EETEA-KAELQRVLSKANSEVAQWR 1372



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 114/594 (19%), Positives = 237/594 (39%), Gaps = 89/594 (14%)

Query: 460  KAQANEQRYSKLKEKYSELVQ--NHADLLRKNAEVTKQVSMARQ---AQVDLEREKKELE 514
            K+   E+  + +KE+++ L +    ++  RK  E  K VS+ ++    Q+ ++ E+  L 
Sbjct: 841  KSAEREKEMASMKEEFTRLKEALEKSEARRKELE-EKMVSLLQEKNDLQLQVQAEQDNLA 899

Query: 515  DSLERISDQGQRKTQ---------EQLEVLESLKQELATSQRELQVLQGSLETSAQSEAN 565
            D+ ER     + K Q         E+LE  E +  EL   +R+L+               
Sbjct: 900  DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE--------------- 944

Query: 566  WAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLV 625
               E +EL+++ D L    A  E+E  A   ++++   ++A  +E + +L K+       
Sbjct: 945  --DECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE------- 995

Query: 626  GSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685
              +KA ++  Q AL+ L+           + L      +   ++ LE S  Q      D+
Sbjct: 996  --KKALQEAHQQALDDLQAE-----EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDL 1048

Query: 686  SGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745
                  +     LT ++I                 L E  K+   E  A  A +E+E +L
Sbjct: 1049 ERAKRKLEGDLKLTQESIMD--------LENDKQQLDERLKKKDFELNALNARIEDEQAL 1100

Query: 746  ENADSTAMRNCLSKIKAIGEEL-LPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804
             +     ++   ++I+ + EEL   R    K E+L   + +E+   S  +E A       
Sbjct: 1101 GSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA------- 1153

Query: 805  LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864
                  G T V++E+N++      +  Q ++      +DL+   ++     A+ ++ +A 
Sbjct: 1154 -----GGATSVQIEMNKK----REAEFQKMR------RDLEEATLQHEATAAALRKKHA- 1197

Query: 865  NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924
                 + +    + +     V         + + + +++     +I  + A L    +  
Sbjct: 1198 -----DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252

Query: 925  ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIK---RQEM 981
             D+ + + ++ ++  R VN  T+              + D  +     LT+ K    Q++
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312

Query: 982  DSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTE 1035
            +   R  +LE E++ +      L+   ++   + E +EE TEA    LQ V+++
Sbjct: 1313 EDLKR--QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAK-AELQRVLSK 1363



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 127/695 (18%), Positives = 265/695 (38%), Gaps = 84/695 (12%)

Query: 387  LKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRED 446
            ++A+ +N+    +R    +K  + +LEA + E      +  +D E + AEL   +R+ ED
Sbjct: 891  VQAEQDNLADAEERCDQLIKNKI-QLEAKVKEMN----ERLEDEEEMNAELTAKKRKLED 945

Query: 447  T-EKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVD 505
               + +R + ++E      E+     + K   L +  A L    A++TK+    ++A   
Sbjct: 946  ECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1005

Query: 506  LEREKKELEDSLERISDQGQRKTQEQLEVLE-SLKQELATS---QRELQVLQGSLETSAQ 561
               + +  ED +  ++ + + K ++Q++ LE SL+QE       +R  + L+G L+ + +
Sbjct: 1006 ALDDLQAEEDKVNTLT-KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064

Query: 562  SEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRK 621
            S         +LE ++  L      ++ EL+AL   ++D Q   +  ++ + +L   Q +
Sbjct: 1065 S-------IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL---QAR 1114

Query: 622  MLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
            +  +     AE+  +  + +L           ++ L     + S  IE  +K  +++   
Sbjct: 1115 IEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKM 1174

Query: 682  PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
              D    L   TL    T+ A+       +    E  D+L    ++  +E   +   L++
Sbjct: 1175 RRD----LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD 1230

Query: 742  EGSLENADSTAMRNCLSKIKAIGEEL------------------------------LPRG 771
              S       A  N     + + +++                              L R 
Sbjct: 1231 VTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ 1290

Query: 772  LDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLM 831
            LD K+  +  L   ++  T   +E    ++EE +    A    ++   ++     C  L 
Sbjct: 1291 LDEKEALISQLTRGKLTYTQ-QLEDLKRQLEEEVKAKNALAHALQSARHD-----CDLLR 1344

Query: 832  QAIQVLIVASKDLQREIVESGRGTASPKEFYAKNS-RWTEGLISASKAVGWGATVMVDAA 890
            +  +    A  +LQR + ++    A  +  Y  ++ + TE L  A K +   A  + +A 
Sbjct: 1345 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL---AQRLQEAE 1401

Query: 891  DLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVV 950
            + V     K   L    H +      L+    V  ++ +   A L +  R  ++  A   
Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLM----VDVERSNAAAAALDKKQRNFDKILAEWK 1457

Query: 951  ASTISGKSQIEETDNMDFSSMT---------------LTQIKRQEMDSQVRVLELENELQ 995
                  +S++E +     S  T               L   KR+  + Q  + +L  +L 
Sbjct: 1458 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517

Query: 996  KERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQ 1030
               + + EL K   +L       +   E +  +L+
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLE 1552



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 117/663 (17%), Positives = 264/663 (39%), Gaps = 67/663 (10%)

Query: 397  ESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSE 456
            E ++ +  +K   + L+  L + +  R++  +    L  E ++L+ Q    +  Q +L++
Sbjct: 844  EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQ---VQAEQDNLAD 900

Query: 457  IERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDS 516
             E +     +   +L+ K  E+ +   D    NAE+T +         +L+R+  +LE +
Sbjct: 901  AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELT 960

Query: 517  LERISDQ---GQRKTQEQLEVLESLKQELATSQRELQVLQGSLETS---AQSEANWAAEF 570
            L ++  +    + K +   E +  L + +A   +E + LQ + + +    Q+E +     
Sbjct: 961  LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1020

Query: 571  AELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS----TEESMCQLAKDQRKMLLVG 626
             + + + +  V       E+   +R +L+  + KL      T+ES+  L  D++++    
Sbjct: 1021 TKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL---D 1077

Query: 627  SRKAAEQVIQDALN-QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685
             R   +    +ALN ++E+   +        L   +  + + IE+LE+           +
Sbjct: 1078 ERLKKKDFELNALNARIEDEQAL-----GSQLQKKLKELQARIEELEEELEAERTARAKV 1132

Query: 686  SGLLHSITLLAHLTSDAI--AHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEG 743
              L   ++      S+ +  A GAT+      +  ++  +  ++   E     A+L+ E 
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE-----ATLQHEA 1187

Query: 744  SL-----ENADSTA-MRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KEMAATSAAIE 795
            +      ++ADS A +   +  ++ + ++L     + K  EL D+    +++    A +E
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL-ELDDVTSNMEQIIKAKANLE 1246

Query: 796  TATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES---- 851
                 +E+ +++ R+     K E  +R +   TS    +Q     + +L R++ E     
Sbjct: 1247 KMCRTLEDQMNEHRS-----KAEETQRSVNDLTSQRAKLQ---TENGELSRQLDEKEALI 1298

Query: 852  ---GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSH 908
                RG  +  +      R  E  + A  A+           DL+ +   +  E      
Sbjct: 1299 SQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1358

Query: 909  EIAASTAQLVAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMD 967
             + +     VA  + K + D+     +L++A +         +A  +    +  E  N  
Sbjct: 1359 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQEAEEAVEAVNAK 1410

Query: 968  FSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPP 1027
             SS+  T+ + Q       + +L  ++++       L KK      +   W++  E S  
Sbjct: 1411 CSSLEKTKHRLQN-----EIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465

Query: 1028 TLQ 1030
             L+
Sbjct: 1466 ELE 1468



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 68/324 (20%), Positives = 128/324 (39%), Gaps = 70/324 (21%)

Query: 369  NKDEKDHLIERLYREISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425
            +++E   + +++  +++ ++ QL +   M  E+Q+ V  L+  + + +  L +       
Sbjct: 1607 SRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD 1666

Query: 426  AADDC-------EFLRAELDELRRQREDTEK----AQRSLSEIERKAQANEQRYSKLKEK 474
              ++          L+AEL+ELR   E TE+    A++ L E   + Q    + + L  +
Sbjct: 1667 LKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1726

Query: 475  YSELVQNHADLLRKNAEVTKQVSMARQAQ------------------------VDLEREK 510
              ++    ADL +   EV + V   R A+                          LER K
Sbjct: 1727 KKKM---DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1783

Query: 511  KELE----------DSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSA 560
            K +E          D  E+I+ +G +K   QL+ LE+  +E          L+  LE   
Sbjct: 1784 KNMEQTIKDLQHRLDEAEQIALKGGKK---QLQKLEARVRE----------LENELEAEQ 1830

Query: 561  QSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQR 620
            +  A       + E+    L        + L  L+  +   QLK+ + +    + A++Q 
Sbjct: 1831 KRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKR-QAEEAEEQA 1889

Query: 621  KMLLVGSRKAAEQVIQDALNQLEE 644
               L   RK     +Q  L++ EE
Sbjct: 1890 NTNLSKFRK-----VQHELDEAEE 1908


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.128    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,456,158
Number of Sequences: 37866
Number of extensions: 1530778
Number of successful extensions: 14042
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 352
Number of HSP's successfully gapped in prelim test: 954
Number of HSP's that attempted gapping in prelim test: 6201
Number of HSP's gapped (non-prelim): 4844
length of query: 1037
length of database: 18,247,518
effective HSP length: 112
effective length of query: 925
effective length of database: 14,006,526
effective search space: 12956036550
effective search space used: 12956036550
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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