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Search of human proteins with 38045919
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38045919 huntingtin interacting protein 1 [Homo sapiens]
(1037 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38045919 huntingtin interacting protein 1 [Homo sapiens] 2019 0.0
gi|48762942 huntingtin interacting protein-1-related [Homo sapiens] 984 0.0
gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens] 842 0.0
gi|156938343 talin 2 [Homo sapiens] 130 6e-30
gi|223029410 talin 1 [Homo sapiens] 127 5e-29
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 77 6e-14
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 77 6e-14
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 77 6e-14
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 77 6e-14
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 75 3e-13
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 75 3e-13
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 75 3e-13
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 75 3e-13
gi|42794779 myosin 18A isoform b [Homo sapiens] 75 3e-13
gi|28416946 myosin 18A isoform a [Homo sapiens] 75 3e-13
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 75 3e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 74 7e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 74 9e-13
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 73 2e-12
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 72 2e-12
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 72 3e-12
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 71 5e-12
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 71 5e-12
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 71 5e-12
gi|31982906 cingulin-like 1 [Homo sapiens] 71 6e-12
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 70 8e-12
gi|16262452 cingulin [Homo sapiens] 70 1e-11
gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens] 69 2e-11
gi|4504063 golgin 97 [Homo sapiens] 69 2e-11
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 69 3e-11
>gi|38045919 huntingtin interacting protein 1 [Homo sapiens]
Length = 1037
Score = 2019 bits (5231), Expect = 0.0
Identities = 1037/1037 (100%), Positives = 1037/1037 (100%)
Query: 1 MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHA 60
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHA
Sbjct: 1 MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHA 60
Query: 61 RTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNE 120
RTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNE
Sbjct: 61 RTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNE 120
Query: 121 LSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN 180
LSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN
Sbjct: 121 LSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN 180
Query: 181 FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTV 240
FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTV
Sbjct: 181 FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTV 240
Query: 241 KLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLR 300
KLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLR
Sbjct: 241 KLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLR 300
Query: 301 ASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF 360
ASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF
Sbjct: 301 ASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF 360
Query: 361 NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQ 420
NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQ
Sbjct: 361 NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQ 420
Query: 421 HLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480
HLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ
Sbjct: 421 HLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480
Query: 481 NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ 540
NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ
Sbjct: 481 NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ 540
Query: 541 ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD 600
ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD
Sbjct: 541 ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD 600
Query: 601 TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLST 660
TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLST
Sbjct: 601 TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLST 660
Query: 661 VTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS 720
VTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS
Sbjct: 661 VTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS 720
Query: 721 LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG 780
LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG
Sbjct: 721 LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG 780
Query: 781 DLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA 840
DLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA
Sbjct: 781 DLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA 840
Query: 841 SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF 900
SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF
Sbjct: 841 SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF 900
Query: 901 EELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQI 960
EELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQI
Sbjct: 901 EELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQI 960
Query: 961 EETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE 1020
EETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE
Sbjct: 961 EETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE 1020
Query: 1021 GTEASPPTLQEVVTEKE 1037
GTEASPPTLQEVVTEKE
Sbjct: 1021 GTEASPPTLQEVVTEKE 1037
>gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]
Length = 1068
Score = 984 bits (2545), Expect = 0.0
Identities = 529/1055 (50%), Positives = 719/1055 (68%), Gaps = 43/1055 (4%)
Query: 8 MKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGT 67
M + N +VLSRR G LEA ERE F++TQ +SI+KAINTQE VKEKHAR ILGT
Sbjct: 1 MNSIKNVPARVLSRRP-GHSLEA-EREQFDKTQAISISKAINTQEAPVKEKHARRIILGT 58
Query: 68 HHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRM 127
HHEKGA TFWS LPL S+++L WKFCHV HK+LRDGHPNVL D RYR+ + ++ +
Sbjct: 59 HHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDL 118
Query: 128 WGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVE 187
WGHL + YGQL ++Y KLL TK+ +H K+P+FP L+++D L++A +DVNN FQLTVE
Sbjct: 119 WGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVE 178
Query: 188 MFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLH 247
MFDY++CEL L ++VF L+ + +VS ++GQCRLAPLIQVI DCSHLY YTVKLLFKLH
Sbjct: 179 MFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLH 238
Query: 248 SCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEH 307
SCLPADTLQGHRDRF EQF L++ F R+S++ YFKRLIQIP+LPE PPNFLRASAL+EH
Sbjct: 239 SCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEH 298
Query: 308 ISPVVVIPAEASSPDSEPVLEKDDLMDMD----ASQQNLFDNKFDDIFGSSFSSDPFNFN 363
I PVVVIP EA P+ E E ++L+++ A + + + FD FG
Sbjct: 299 IKPVVVIPEEA--PEDE---EPENLIEISTGPPAGEPVVVADLFDQTFGPP--------- 344
Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLR 423
NG KD++D IE L RE+ L+++LE +K E+QR + QLK V+ LE +L EQ+ +
Sbjct: 345 --NGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQK 402
Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
Q+A D E LR EL +LR + + E++Q E ERKA A E RY+KLKEK+SELV HA
Sbjct: 403 QKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 462
Query: 484 DLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELA 543
+LLRKNA+ KQ+++ +Q+Q ++ R K++L +E++ + + K +E+ + LE LK+EL
Sbjct: 463 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE 522
Query: 544 TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603
EL Q +L + QS++ ++ L E+D+L RE +L A + +++T+
Sbjct: 523 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
Query: 604 KLA---------------------STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQL 642
L+ S E+ + Q D++ +L G+ A ++QDA+++L
Sbjct: 583 ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKL 642
Query: 643 EEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDA 702
++P + C S D+L+S + LE+ +QYL D S L+ ++T +HL +D
Sbjct: 643 DDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADT 702
Query: 703 IAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKA 762
I +G T AP +PAD L + C++ G L + L+++ +L + ++ +R L I
Sbjct: 703 IINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQ 762
Query: 763 IGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNER 822
+G+EL P+ LD++QEELG +VDKEMAATSAAIE A RIE+M++++R +GVKLEVNER
Sbjct: 763 LGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER 822
Query: 823 ILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWG 882
IL CT LM+AI++L+ S LQ+EIVESGRG A+ +EFYAKNSRWTEGLISASKAVGWG
Sbjct: 823 ILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWG 882
Query: 883 ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGV 942
AT +V+AAD VV GK+EEL+VCSHEIAASTAQLVAASKVKA+K SP+L++LQ+ SR V
Sbjct: 883 ATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTV 942
Query: 943 NQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLG 1002
N+ A VVAST SG+ QIE+ D MDFS ++L ++K+QEM++QVRVLELE L+ ER +LG
Sbjct: 943 NERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLG 1002
Query: 1003 ELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037
ELRK+HY LAG + E P T VT K+
Sbjct: 1003 ELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1037
>gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]
Length = 1048
Score = 842 bits (2176), Expect = 0.0
Identities = 477/1035 (46%), Positives = 660/1035 (63%), Gaps = 68/1035 (6%)
Query: 40 QTVSINKAINTQEVAVKEKHARTCILGTH----HEKGAQTFW-----SVVNRLPLSSNAV 90
+ V+ + + + A +E CIL TH G W S V +P A
Sbjct: 14 EPVAGRRFLGSPRPAAEESGLEVCILSTHTVRPESPGGPAIWMHCKTSGVRDVPGGQRA- 72
Query: 91 LCW---KFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLR 147
L W + C V L RD D GHL + YGQL ++Y KLL
Sbjct: 73 LAWFSLEHCGVLVCLGRDIGAGQALDR--------------GHLHDRYGQLVNVYTKLLL 118
Query: 148 TKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLD 207
TK+ +H K+P+FP L+++D L++A +DVNN FQLTVEMFDY++CEL L ++VF L+
Sbjct: 119 TKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLN 178
Query: 208 MSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFT 267
+ +VS ++GQCRLAPLIQVI DCSHLY YTVKLLFKLHSCLPADTLQGHRDRF EQF
Sbjct: 179 TAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFH 238
Query: 268 KLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVL 327
L++ F R+S++ YFKRLIQIP+LPE PPNFLRASAL+EHI PVVVIP EA P+ E
Sbjct: 239 SLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEA--PEDE--- 293
Query: 328 EKDDLMDMD----ASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYRE 383
E ++L+++ A + + + FD FG NG KD++D IE L RE
Sbjct: 294 EPENLIEISTGPPAGEPVVVADLFDQTFGPP-----------NGSVKDDRDLQIESLKRE 342
Query: 384 ISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQ 443
+ L+++LE +K E+QR + QLK V+ LE +L EQ+ +Q+A D E LR EL +LR
Sbjct: 343 VEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAA 402
Query: 444 REDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ 503
+ + E++Q E ERKA A E RY+KLKEK+SELV HA+LLRKNA+ KQ+++ +Q+Q
Sbjct: 403 QLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQ 462
Query: 504 VDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSE 563
++ R K++L +E++ + + K +E+ + LE LK+EL EL Q +L + QS+
Sbjct: 463 EEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSK 522
Query: 564 ANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLA----------------- 606
+ ++ L E+D+L RE +L A + +++T+ L+
Sbjct: 523 SELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 582
Query: 607 ----STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVT 662
S E+ + Q D++ +L G+ A ++QDA+++L++P + C S D+L+S
Sbjct: 583 AERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQ 642
Query: 663 SISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLT 722
+ LE+ +QYL D S L+ ++T +HL +D I +G T AP +PAD L
Sbjct: 643 EALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI 702
Query: 723 EACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL 782
+ C++ G L + L+++ +L + ++ +R L I +G+EL P+ LD++QEELG +
Sbjct: 703 DTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAV 762
Query: 783 VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK 842
VDKEMAATSAAIE A RIE+M++++R +GVKLEVNERIL CT LM+AI++L+ S
Sbjct: 763 VDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTST 822
Query: 843 DLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEE 902
LQ+EIVESGRG A+ +EFYAKNSRWTEGLISASKAVGWGAT +V+AAD VV GK+EE
Sbjct: 823 SLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEE 882
Query: 903 LMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
L+VCSHEIAASTAQLVAASKVKA+K SP+L++LQ+ SR VN+ A VVAST SG+ QIE+
Sbjct: 883 LIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIED 942
Query: 963 TDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022
D MDFS ++L ++K+QEM++QVRVLELE L+ ER +LGELRK+HY LAG + E
Sbjct: 943 RDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEV 1002
Query: 1023 EASPPTLQEVVTEKE 1037
P T VT K+
Sbjct: 1003 AIRPSTAPRSVTTKK 1017
>gi|156938343 talin 2 [Homo sapiens]
Length = 2542
Score = 130 bits (327), Expect = 6e-30
Identities = 124/534 (23%), Positives = 239/534 (44%), Gaps = 71/534 (13%)
Query: 557 ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEE-SMCQL 615
ET A N L ++ LVSGAA ++L+ + T +LA + L
Sbjct: 2011 ETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASL 2070
Query: 616 AKD--QRKMLLVGSRKAAEQVIQDALNQ--------LEEPPLISCAGSADHLLSTVTSIS 665
D + +++L+ + K + + D ++ +++P + G+A +++ VTS+
Sbjct: 2071 GSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLL 2130
Query: 666 SCIEQLE--------------------------KSWSQYLACPEDISGLLHSITLL---- 695
++ +E K + + PE+ + IT+
Sbjct: 2131 KTVKAVEDEATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKA 2190
Query: 696 ---------------AHLTSDAIAHGATTCLRAP--PEPADSLTEACKQYGRE-TLAYLA 737
A+L+ A++ T C +A P+ +D + ++G E TL YL
Sbjct: 2191 VAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPDVSDEVRTRALRFGTECTLGYLD 2250
Query: 738 SLEEEGSLENADSTAMRNCLS----KIKAIGEELLPRGLDIKQEELGD------LVDKEM 787
LE + + + L+ ++ EL+ +K E D + + E+
Sbjct: 2251 LLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETEL 2310
Query: 788 AATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQRE 847
+A+IE A ++E++ +++ L+ E+IL S+ A L+ ++ QRE
Sbjct: 2311 LGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRE 2370
Query: 848 IVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCS 907
+V G+ + P A + +W++GLISA++ V + + +AA+ VQG E+L+ +
Sbjct: 2371 LVAQGKVGSIPANA-ADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISSA 2429
Query: 908 HEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMD 967
++AASTAQL+ A KVKAD+DS + +LQ A V +A+ +V + + D++
Sbjct: 2430 KQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVV 2489
Query: 968 FSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEG 1021
+ + I Q + +Q +L+ E EL++ R+KL ++R++ Y+ +EG
Sbjct: 2490 VKTKFVGGI-AQIIAAQEEMLKKERELEEARKKLAQIRQQQYKFLPTELREDEG 2542
Score = 38.9 bits (89), Expect = 0.025
Identities = 51/194 (26%), Positives = 78/194 (40%), Gaps = 48/194 (24%)
Query: 780 GDLVDKEMAATSAAIETATARIEEM---------LSKSRAGDTGVKLEVNERILGCCTSL 830
GD D + A AI T ++ + EM L G L + G + L
Sbjct: 566 GDPADTDYTAVGCAITTISSNLTEMSKGVKLLAALMDDEVGSGEDLLRAARTLAGAVSDL 625
Query: 831 MQAIQ---------VLIVA------SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISA 875
++A+Q VL A S DL R+I E+ + R+ + L+S
Sbjct: 626 LKAVQPTSGEPRQTVLTAAGSIGQASGDLLRQIGEN-----------ETDERFQDVLMSL 674
Query: 876 SKAVGWGATVMV--------DAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADK 927
+KAV A ++V A D V+Q R ++ + + A ST+QLVA +KV +
Sbjct: 675 AKAVANAAAMLVLKAKNVAQVAEDTVLQNR-----VIAAATQCALSTSQLVACAKVVSPT 729
Query: 928 DSPNLAQLQQASRG 941
S + Q Q G
Sbjct: 730 ISSPVCQEQLIEAG 743
>gi|223029410 talin 1 [Homo sapiens]
Length = 2541
Score = 127 bits (319), Expect = 5e-29
Identities = 156/641 (24%), Positives = 260/641 (40%), Gaps = 106/641 (16%)
Query: 461 AQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERI 520
A NE+ S +K + EL A L+ K A Q KKEL + R+
Sbjct: 1906 AAENEEIGSHIKHRVQELGHGCAALVTKAG--------ALQCSPSDAYTKKELIECARRV 1957
Query: 521 SDQ----------GQRKTQEQLEVLESLKQELATSQRELQ-VLQGSL-----ETSAQSEA 564
S++ G R TQ + ++ +A + G+L ET A
Sbjct: 1958 SEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHRE 2017
Query: 565 NWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS---------------TE 609
L ++ LV AA +E+L+ + T +LA T+
Sbjct: 2018 GILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQ 2077
Query: 610 ESMCQLAKDQRKML--LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSC 667
+ KD K L L+ + KAA + D +P + SA +++ VTS+
Sbjct: 2078 VVLINAVKDVAKALGDLISATKAAAGKVGD------DPAVWQLKNSAKVMVTNVTSLLKT 2131
Query: 668 IEQLEKSWS--------------QYLAC------------PEDISGLLHSITLL------ 695
++ +E + Q LA PED + IT+
Sbjct: 2132 VKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVA 2191
Query: 696 -------------AHLTSDAIAHGATTCLRAP--PEPADSLTEACKQYGRETL-AYLASL 739
A+L+ AIA C A PE A + YGRE YL L
Sbjct: 2192 AGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELL 2251
Query: 740 EEEGSLENADSTAMRNCLS----KIKAIGEELLPRGLDIKQEELGD------LVDKEMAA 789
+ S ++ L+ ++ EL+ +K E D + + E+
Sbjct: 2252 DHVLLTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLG 2311
Query: 790 TSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIV 849
+AAIE A ++E++ +++ + L E+IL S+ A L+ A+ QRE+V
Sbjct: 2312 AAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELV 2371
Query: 850 ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHE 909
G+ A P + +W++GLISA++ V + +AA+ VQG E+L+ + +
Sbjct: 2372 AQGKVGAIPANAL-DDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQ 2430
Query: 910 IAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFS 969
+AASTAQL+ A KVKAD+DS + +LQ A V +A+ +V + + E+ +
Sbjct: 2431 VAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVV 2490
Query: 970 SMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010
+ Q + +Q +L E EL++ R+KL ++R++ Y+
Sbjct: 2491 KEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYK 2531
Score = 40.0 bits (92), Expect = 0.011
Identities = 47/195 (24%), Positives = 88/195 (45%), Gaps = 24/195 (12%)
Query: 780 GDLVDKEMAATSAAIETATARIEEM---------LSKSRAGDTGVKLEVNERILGCCTSL 830
GD + + A A+ T ++ + EM L + G L+ + + G + L
Sbjct: 563 GDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSEL 622
Query: 831 MQAIQVLIVASKDLQREIVESGR--GTASPKEFYA-----KNSRWTEGLISASKAVGWGA 883
+++ Q AS + ++ ++++ G AS + + + + L+ +KAV A
Sbjct: 623 LRSAQP---ASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALMQLAKAVASAA 679
Query: 884 TVMVDAADLVVQ---GRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLA--QLQQA 938
+V A V Q G +++ + + A ST+QLVA +KV A S + QL +A
Sbjct: 680 AALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEA 739
Query: 939 SRGVNQATAGVVAST 953
R V +A G V+++
Sbjct: 740 GRLVAKAVEGCVSAS 754
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 77.4 bits (189), Expect = 6e-14
Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%)
Query: 383 EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439
E+ A+L++ K + + + +L+GH+S+L+ DL ++ R +A L EL+
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 440 LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480
L+ + EDT + + E+ K + ++E + ++++K+++ V+
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 481 --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523
N L ++NA++ ++ + QA+ ++E +KK+LE ++ + +
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 524 GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562
G+R K Q ++E + L +++A+ +LQ Q L+ +
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 563 EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612
+ N + + +LE+ER+SL + + E +S L +L D++ KL AST E++
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 613 CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664
+ K +K + + AA ++ N+L++ D L L +
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1442
Query: 665 SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721
S +E+ ++ + Q LA ++IS A + + A L E + L
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 722 TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769
K E ++S ++ G + A T M ++++ + +EL
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 770 RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809
L++ + L ++++ A E +++ L K
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 810 AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868
GD ++L+ + I G ++ Q ++ L KD QRE+ ++ AS E +A
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1677
Query: 869 TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928
+ KA A +M DL R + ++ + E+A A ++ D+
Sbjct: 1678 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 929 SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988
A++ Q + + + A + + ++ + + + + + Q+ +S + L
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1790
Query: 989 ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036
E +N+ ELR K +E+ G + + T EA L+E V ++
Sbjct: 1791 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Score = 62.8 bits (151), Expect = 2e-09
Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%)
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
+ R E+ + +L+ K Q+ +LK + + + L E+++L Q+ L AE
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 437 LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495
+E+R R ++ + L E+E + + E R +L+ + ++ Q DL + E
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 496 VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555
+ +V E + K+LED + + DQ + ++E+ ++LE +L T+ E + +
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1024
Query: 556 LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
L + +E ELEK + L A+ E+++ L+ ++ + +++
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 605 LASTEESM 612
LA EE +
Sbjct: 1085 LAKKEEEL 1092
Score = 60.5 bits (145), Expect = 8e-09
Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%)
Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
E ++A+ DEL++ +E +KA+ L E+E+K + ++ K E +Q +L +
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537
E+ +++ +Q +LE E+E LE D+GQ+ +EQLE E+
Sbjct: 908 EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 538 LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593
+Q+L T++ +++ L+ + + E LE+ L + A EE+
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 594 LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
L K + + +++L E+S +L K +RK L G + I D Q+ E
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1082
Query: 647 LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706
+ A + L + + + I Q + + ++ G H L L S+ A
Sbjct: 1083 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1135
Query: 707 ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
+A + D G E A LE + DSTA + L +
Sbjct: 1136 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1177
Query: 767 LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824
+L + LD + V + + A+E T ++E+ +K+ LE N +
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 825 GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884
G L QA Q + K L+ ++ E + + A+ + L + ++V T
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1293
Query: 885 VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944
M++ A+ GK +L + ++A+ ++QL +D+ L Q ++ + +N
Sbjct: 1294 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1334
Query: 945 ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004
+T Q+EE N +L +EM+++ LE + +L +
Sbjct: 1335 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1376
Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037
+KK + A E EEG + ++ + + E
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409
Score = 59.7 bits (143), Expect = 1e-08
Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%)
Query: 324 EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381
+ +L DD + + ++ L + + D+ + + N NK E L RL
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044
Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
+E + +LE +K + + +++L+A +AE L+ Q A E L+A L L
Sbjct: 1045 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1099
Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
D E AQ++ K++E + DL + A K R
Sbjct: 1100 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 502 AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558
+LE K ELED+L+ + Q + + + + EV ++L +E + + ++Q ++
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 559 SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614
+ + +F A L+K + +L A EL L + Q+ + K E + +
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 615 LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668
L + G R AE + D +++L+ L G A L V S+SS +
Sbjct: 1264 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 669 EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728
+ ++ LL T + +T LR E +SL +
Sbjct: 1318 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1353
Query: 729 GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786
E + +LE S N + + L A E L G Q+E+ +L +E
Sbjct: 1354 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 787 MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846
AA +E R+++ L D V L+ +++ + L+ K++
Sbjct: 1411 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 847 EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905
+ E R A +E K +S ++A+ + + + E+L+
Sbjct: 1466 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 906 CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
++ + +L A + + ++ L +L+ + A + + + K Q E
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 963 TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010
D + + KR+++ Q+ E E E +++++ L KK E
Sbjct: 1579 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Score = 56.2 bits (134), Expect = 2e-07
Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%)
Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434
R++ + L++ E L+ H+S L L++ + Q A E L +
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398
Query: 435 AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480
E++ L +Q E+ A L + + + Q + QR K + K+ +L+
Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458
Query: 481 NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518
++ K A+ TK +S+AR +A+ +LER K E+ED +
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 519 RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575
D G+ + ++ LE+ +E+ T EL+ LQ + + + E N A + E+
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 576 ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
+ L + EE+ L+++L +T+L+ + ++ AK + + L A+
Sbjct: 1579 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 634 VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
I ++A+ QL + L S D + +T + LE + +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1692
Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
ED++ A L + +A + L S A + R A +A LEE
Sbjct: 1693 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1743
Query: 742 EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778
E E + AM + + K E+L + L K E
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803
Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSK 807
+ V + +T AA+E A++EE + +
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Score = 55.5 bits (132), Expect = 3e-07
Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%)
Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427
++ + +L R++ + +LE+ + + +L+G + +LE R++A
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 428 DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
L+A++ + +R+ ED A+ S EI A+ NE++ L+ ADL++
Sbjct: 1645 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1691
Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
++ +QA ++ E +EL SL G+ Q++ LE+ +A +
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1743
Query: 548 ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607
EL+ QG++E + + +L E + S A E L ++ ++ + KL
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803
Query: 608 TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638
E ++ K L + EQV Q+A
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Score = 52.0 bits (123), Expect = 3e-06
Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%)
Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
K E + ++ + + + + + ++ E +++ Q+ +LE + A +Q L+ +
Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 430 CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489
++ DE+ + K + ERK L+E+ S+L N A+ K
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1022
Query: 490 AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539
+T K SM + +V L++E+K + + L+R + EQ+ L++ LK
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588
+LA + ELQ L+ + N + ELE ++ L S A R
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 589 ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
EEL AL+ EL+DT A+ +E + +R+ + +KA ++ + Q++E
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Score = 51.6 bits (122), Expect = 4e-06
Identities = 64/281 (22%), Positives = 121/281 (43%), Gaps = 40/281 (14%)
Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
EK+ L E L +SG A L++ K + + QL+ + E + ++ ++A E
Sbjct: 1709 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 432 FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487
L +EL +R +K + + ++ER+ N++ SKL E S+ A L
Sbjct: 1768 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 488 KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELA 543
K A++ +QV AR+ Q L+++ K+L++ L ++ D+ RK EQ K++
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE--RKMAEQY------KEQAE 1873
Query: 544 TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603
++ L+ LE + + A +L++E D E++AL+ +L+
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR---- 1929
Query: 604 KLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
+ + R +VI++A EE
Sbjct: 1930 -------------RGNETSFVPSRRSGGRRVIENADGSEEE 1957
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 77.4 bits (189), Expect = 6e-14
Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%)
Query: 383 EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439
E+ A+L++ K + + + +L+GH+S+L+ DL ++ R +A L EL+
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 440 LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480
L+ + EDT + + E+ K + ++E + ++++K+++ V+
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Query: 481 --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523
N L ++NA++ ++ + QA+ ++E +KK+LE ++ + +
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 524 GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562
G+R K Q ++E + L +++A+ +LQ Q L+ +
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337
Query: 563 EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612
+ N + + +LE+ER+SL + + E +S L +L D++ KL AST E++
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 613 CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664
+ K +K + + AA ++ N+L++ D L L +
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1449
Query: 665 SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721
S +E+ ++ + Q LA ++IS A + + A L E + L
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 722 TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769
K E ++S ++ G + A T M ++++ + +EL
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 770 RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809
L++ + L ++++ A E +++ L K
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 810 AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868
GD ++L+ + I G ++ Q ++ L KD QRE+ ++ AS E +A
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1684
Query: 869 TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928
+ KA A +M DL R + ++ + E+A A ++ D+
Sbjct: 1685 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 929 SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988
A++ Q + + + A + + ++ + + + + + Q+ +S + L
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1797
Query: 989 ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036
E +N+ ELR K +E+ G + + T EA L+E V ++
Sbjct: 1798 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Score = 62.8 bits (151), Expect = 2e-09
Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%)
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
+ R E+ + +L+ K Q+ +LK + + + L E+++L Q+ L AE
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 437 LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495
+E+R R ++ + L E+E + + E R +L+ + ++ Q DL + E
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 496 VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555
+ +V E + K+LED + + DQ + ++E+ ++LE +L T+ E + +
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1031
Query: 556 LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
L + +E ELEK + L A+ E+++ L+ ++ + +++
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 605 LASTEESM 612
LA EE +
Sbjct: 1092 LAKKEEEL 1099
Score = 60.5 bits (145), Expect = 8e-09
Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%)
Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
E ++A+ DEL++ +E +KA+ L E+E+K + ++ K E +Q +L +
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537
E+ +++ +Q +LE E+E LE D+GQ+ +EQLE E+
Sbjct: 915 EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 538 LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593
+Q+L T++ +++ L+ + + E LE+ L + A EE+
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 594 LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
L K + + +++L E+S +L K +RK L G + I D Q+ E
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1089
Query: 647 LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706
+ A + L + + + I Q + + ++ G H L L S+ A
Sbjct: 1090 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1142
Query: 707 ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
+A + D G E A LE + DSTA + L +
Sbjct: 1143 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1184
Query: 767 LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824
+L + LD + V + + A+E T ++E+ +K+ LE N +
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 825 GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884
G L QA Q + K L+ ++ E + + A+ + L + ++V T
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1300
Query: 885 VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944
M++ A+ GK +L + ++A+ ++QL +D+ L Q ++ + +N
Sbjct: 1301 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1341
Query: 945 ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004
+T Q+EE N +L +EM+++ LE + +L +
Sbjct: 1342 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1383
Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037
+KK + A E EEG + ++ + + E
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416
Score = 59.7 bits (143), Expect = 1e-08
Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%)
Query: 324 EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381
+ +L DD + + ++ L + + D+ + + N NK E L RL
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051
Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
+E + +LE +K + + +++L+A +AE L+ Q A E L+A L L
Sbjct: 1052 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1106
Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
D E AQ++ K++E + DL + A K R
Sbjct: 1107 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 502 AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558
+LE K ELED+L+ + Q + + + + EV ++L +E + + ++Q ++
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 559 SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614
+ + +F A L+K + +L A EL L + Q+ + K E + +
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 615 LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668
L + G R AE + D +++L+ L G A L V S+SS +
Sbjct: 1271 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 669 EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728
+ ++ LL T + +T LR E +SL +
Sbjct: 1325 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1360
Query: 729 GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786
E + +LE S N + + L A E L G Q+E+ +L +E
Sbjct: 1361 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 787 MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846
AA +E R+++ L D V L+ +++ + L+ K++
Sbjct: 1418 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 847 EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905
+ E R A +E K +S ++A+ + + + E+L+
Sbjct: 1473 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 906 CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
++ + +L A + + ++ L +L+ + A + + + K Q E
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 963 TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010
D + + KR+++ Q+ E E E +++++ L KK E
Sbjct: 1586 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Score = 56.2 bits (134), Expect = 2e-07
Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%)
Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434
R++ + L++ E L+ H+S L L++ + Q A E L +
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405
Query: 435 AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480
E++ L +Q E+ A L + + + Q + QR K + K+ +L+
Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465
Query: 481 NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518
++ K A+ TK +S+AR +A+ +LER K E+ED +
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 519 RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575
D G+ + ++ LE+ +E+ T EL+ LQ + + + E N A + E+
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 576 ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
+ L + EE+ L+++L +T+L+ + ++ AK + + L A+
Sbjct: 1586 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 634 VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
I ++A+ QL + L S D + +T + LE + +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1699
Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
ED++ A L + +A + L S A + R A +A LEE
Sbjct: 1700 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1750
Query: 742 EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778
E E + AM + + K E+L + L K E
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810
Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSK 807
+ V + +T AA+E A++EE + +
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Score = 55.5 bits (132), Expect = 3e-07
Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%)
Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427
++ + +L R++ + +LE+ + + +L+G + +LE R++A
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 428 DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
L+A++ + +R+ ED A+ S EI A+ NE++ L+ ADL++
Sbjct: 1652 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1698
Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
++ +QA ++ E +EL SL G+ Q++ LE+ +A +
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1750
Query: 548 ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607
EL+ QG++E + + +L E + S A E L ++ ++ + KL
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810
Query: 608 TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638
E ++ K L + EQV Q+A
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Score = 52.0 bits (123), Expect = 3e-06
Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%)
Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
K E + ++ + + + + + ++ E +++ Q+ +LE + A +Q L+ +
Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 430 CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489
++ DE+ + K + ERK L+E+ S+L N A+ K
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1029
Query: 490 AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539
+T K SM + +V L++E+K + + L+R + EQ+ L++ LK
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588
+LA + ELQ L+ + N + ELE ++ L S A R
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 589 ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
EEL AL+ EL+DT A+ +E + +R+ + +KA ++ + Q++E
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Score = 51.6 bits (122), Expect = 4e-06
Identities = 64/281 (22%), Positives = 121/281 (43%), Gaps = 40/281 (14%)
Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
EK+ L E L +SG A L++ K + + QL+ + E + ++ ++A E
Sbjct: 1716 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 432 FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487
L +EL +R +K + + ++ER+ N++ SKL E S+ A L
Sbjct: 1775 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 488 KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELA 543
K A++ +QV AR+ Q L+++ K+L++ L ++ D+ RK EQ K++
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE--RKMAEQY------KEQAE 1880
Query: 544 TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603
++ L+ LE + + A +L++E D E++AL+ +L+
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR---- 1936
Query: 604 KLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
+ + R +VI++A EE
Sbjct: 1937 -------------RGNETSFVPSRRSGGRRVIENADGSEEE 1964
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 77.4 bits (189), Expect = 6e-14
Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%)
Query: 383 EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439
E+ A+L++ K + + + +L+GH+S+L+ DL ++ R +A L EL+
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 440 LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480
L+ + EDT + + E+ K + ++E + ++++K+++ V+
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Query: 481 --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523
N L ++NA++ ++ + QA+ ++E +KK+LE ++ + +
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 524 GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562
G+R K Q ++E + L +++A+ +LQ Q L+ +
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337
Query: 563 EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612
+ N + + +LE+ER+SL + + E +S L +L D++ KL AST E++
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 613 CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664
+ K +K + + AA ++ N+L++ D L L +
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1449
Query: 665 SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721
S +E+ ++ + Q LA ++IS A + + A L E + L
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 722 TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769
K E ++S ++ G + A T M ++++ + +EL
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 770 RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809
L++ + L ++++ A E +++ L K
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 810 AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868
GD ++L+ + I G ++ Q ++ L KD QRE+ ++ AS E +A
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1684
Query: 869 TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928
+ KA A +M DL R + ++ + E+A A ++ D+
Sbjct: 1685 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 929 SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988
A++ Q + + + A + + ++ + + + + + Q+ +S + L
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1797
Query: 989 ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036
E +N+ ELR K +E+ G + + T EA L+E V ++
Sbjct: 1798 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Score = 62.8 bits (151), Expect = 2e-09
Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%)
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
+ R E+ + +L+ K Q+ +LK + + + L E+++L Q+ L AE
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 437 LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495
+E+R R ++ + L E+E + + E R +L+ + ++ Q DL + E
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 496 VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555
+ +V E + K+LED + + DQ + ++E+ ++LE +L T+ E + +
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1031
Query: 556 LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
L + +E ELEK + L A+ E+++ L+ ++ + +++
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 605 LASTEESM 612
LA EE +
Sbjct: 1092 LAKKEEEL 1099
Score = 60.5 bits (145), Expect = 8e-09
Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%)
Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
E ++A+ DEL++ +E +KA+ L E+E+K + ++ K E +Q +L +
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537
E+ +++ +Q +LE E+E LE D+GQ+ +EQLE E+
Sbjct: 915 EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 538 LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593
+Q+L T++ +++ L+ + + E LE+ L + A EE+
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 594 LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
L K + + +++L E+S +L K +RK L G + I D Q+ E
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1089
Query: 647 LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706
+ A + L + + + I Q + + ++ G H L L S+ A
Sbjct: 1090 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1142
Query: 707 ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
+A + D G E A LE + DSTA + L +
Sbjct: 1143 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1184
Query: 767 LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824
+L + LD + V + + A+E T ++E+ +K+ LE N +
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 825 GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884
G L QA Q + K L+ ++ E + + A+ + L + ++V T
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1300
Query: 885 VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944
M++ A+ GK +L + ++A+ ++QL +D+ L Q ++ + +N
Sbjct: 1301 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1341
Query: 945 ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004
+T Q+EE N +L +EM+++ LE + +L +
Sbjct: 1342 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1383
Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037
+KK + A E EEG + ++ + + E
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416
Score = 59.7 bits (143), Expect = 1e-08
Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%)
Query: 324 EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381
+ +L DD + + ++ L + + D+ + + N NK E L RL
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051
Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
+E + +LE +K + + +++L+A +AE L+ Q A E L+A L L
Sbjct: 1052 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1106
Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
D E AQ++ K++E + DL + A K R
Sbjct: 1107 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 502 AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558
+LE K ELED+L+ + Q + + + + EV ++L +E + + ++Q ++
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 559 SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614
+ + +F A L+K + +L A EL L + Q+ + K E + +
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 615 LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668
L + G R AE + D +++L+ L G A L V S+SS +
Sbjct: 1271 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 669 EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728
+ ++ LL T + +T LR E +SL +
Sbjct: 1325 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1360
Query: 729 GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786
E + +LE S N + + L A E L G Q+E+ +L +E
Sbjct: 1361 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 787 MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846
AA +E R+++ L D V L+ +++ + L+ K++
Sbjct: 1418 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 847 EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905
+ E R A +E K +S ++A+ + + + E+L+
Sbjct: 1473 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 906 CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
++ + +L A + + ++ L +L+ + A + + + K Q E
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 963 TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010
D + + KR+++ Q+ E E E +++++ L KK E
Sbjct: 1586 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Score = 56.2 bits (134), Expect = 2e-07
Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%)
Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434
R++ + L++ E L+ H+S L L++ + Q A E L +
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405
Query: 435 AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480
E++ L +Q E+ A L + + + Q + QR K + K+ +L+
Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465
Query: 481 NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518
++ K A+ TK +S+AR +A+ +LER K E+ED +
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 519 RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575
D G+ + ++ LE+ +E+ T EL+ LQ + + + E N A + E+
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 576 ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
+ L + EE+ L+++L +T+L+ + ++ AK + + L A+
Sbjct: 1586 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 634 VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
I ++A+ QL + L S D + +T + LE + +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1699
Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
ED++ A L + +A + L S A + R A +A LEE
Sbjct: 1700 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1750
Query: 742 EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778
E E + AM + + K E+L + L K E
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810
Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSK 807
+ V + +T AA+E A++EE + +
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Score = 55.5 bits (132), Expect = 3e-07
Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%)
Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427
++ + +L R++ + +LE+ + + +L+G + +LE R++A
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 428 DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
L+A++ + +R+ ED A+ S EI A+ NE++ L+ ADL++
Sbjct: 1652 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1698
Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
++ +QA ++ E +EL SL G+ Q++ LE+ +A +
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1750
Query: 548 ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607
EL+ QG++E + + +L E + S A E L ++ ++ + KL
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810
Query: 608 TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638
E ++ K L + EQV Q+A
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Score = 52.0 bits (123), Expect = 3e-06
Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%)
Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
K E + ++ + + + + + ++ E +++ Q+ +LE + A +Q L+ +
Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 430 CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489
++ DE+ + K + ERK L+E+ S+L N A+ K
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1029
Query: 490 AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539
+T K SM + +V L++E+K + + L+R + EQ+ L++ LK
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588
+LA + ELQ L+ + N + ELE ++ L S A R
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 589 ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
EEL AL+ EL+DT A+ +E + +R+ + +KA ++ + Q++E
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Score = 46.2 bits (108), Expect = 2e-04
Identities = 50/203 (24%), Positives = 95/203 (46%), Gaps = 31/203 (15%)
Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
EK+ L E L +SG A L++ K + + QL+ + E + ++ ++A E
Sbjct: 1716 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 432 FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487
L +EL +R +K + + ++ER+ N++ SKL E S+ A L
Sbjct: 1775 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 488 KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQ----------------RK 527
K A++ +QV AR+ Q L+++ K+L++ L ++ D+ + ++
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Query: 528 TQEQLEVLESLKQELATSQRELQ 550
+ QLE E Q + ++R+LQ
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQ 1911
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 77.4 bits (189), Expect = 6e-14
Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%)
Query: 383 EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439
E+ A+L++ K + + + +L+GH+S+L+ DL ++ R +A L EL+
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 440 LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480
L+ + EDT + + E+ K + ++E + ++++K+++ V+
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 481 --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523
N L ++NA++ ++ + QA+ ++E +KK+LE ++ + +
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 524 GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562
G+R K Q ++E + L +++A+ +LQ Q L+ +
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 563 EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612
+ N + + +LE+ER+SL + + E +S L +L D++ KL AST E++
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 613 CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664
+ K +K + + AA ++ N+L++ D L L +
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1442
Query: 665 SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721
S +E+ ++ + Q LA ++IS A + + A L E + L
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 722 TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769
K E ++S ++ G + A T M ++++ + +EL
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 770 RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809
L++ + L ++++ A E +++ L K
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 810 AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868
GD ++L+ + I G ++ Q ++ L KD QRE+ ++ AS E +A
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1677
Query: 869 TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928
+ KA A +M DL R + ++ + E+A A ++ D+
Sbjct: 1678 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 929 SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988
A++ Q + + + A + + ++ + + + + + Q+ +S + L
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1790
Query: 989 ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036
E +N+ ELR K +E+ G + + T EA L+E V ++
Sbjct: 1791 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Score = 62.8 bits (151), Expect = 2e-09
Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%)
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
+ R E+ + +L+ K Q+ +LK + + + L E+++L Q+ L AE
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 437 LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495
+E+R R ++ + L E+E + + E R +L+ + ++ Q DL + E
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 496 VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555
+ +V E + K+LED + + DQ + ++E+ ++LE +L T+ E + +
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1024
Query: 556 LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
L + +E ELEK + L A+ E+++ L+ ++ + +++
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 605 LASTEESM 612
LA EE +
Sbjct: 1085 LAKKEEEL 1092
Score = 60.5 bits (145), Expect = 8e-09
Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%)
Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
E ++A+ DEL++ +E +KA+ L E+E+K + ++ K E +Q +L +
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537
E+ +++ +Q +LE E+E LE D+GQ+ +EQLE E+
Sbjct: 908 EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 538 LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593
+Q+L T++ +++ L+ + + E LE+ L + A EE+
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 594 LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
L K + + +++L E+S +L K +RK L G + I D Q+ E
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1082
Query: 647 LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706
+ A + L + + + I Q + + ++ G H L L S+ A
Sbjct: 1083 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1135
Query: 707 ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
+A + D G E A LE + DSTA + L +
Sbjct: 1136 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1177
Query: 767 LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824
+L + LD + V + + A+E T ++E+ +K+ LE N +
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 825 GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884
G L QA Q + K L+ ++ E + + A+ + L + ++V T
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1293
Query: 885 VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944
M++ A+ GK +L + ++A+ ++QL +D+ L Q ++ + +N
Sbjct: 1294 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1334
Query: 945 ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004
+T Q+EE N +L +EM+++ LE + +L +
Sbjct: 1335 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1376
Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037
+KK + A E EEG + ++ + + E
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409
Score = 59.7 bits (143), Expect = 1e-08
Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%)
Query: 324 EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381
+ +L DD + + ++ L + + D+ + + N NK E L RL
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044
Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
+E + +LE +K + + +++L+A +AE L+ Q A E L+A L L
Sbjct: 1045 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1099
Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
D E AQ++ K++E + DL + A K R
Sbjct: 1100 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 502 AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558
+LE K ELED+L+ + Q + + + + EV ++L +E + + ++Q ++
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 559 SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614
+ + +F A L+K + +L A EL L + Q+ + K E + +
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 615 LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668
L + G R AE + D +++L+ L G A L V S+SS +
Sbjct: 1264 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 669 EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728
+ ++ LL T + +T LR E +SL +
Sbjct: 1318 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1353
Query: 729 GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786
E + +LE S N + + L A E L G Q+E+ +L +E
Sbjct: 1354 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 787 MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846
AA +E R+++ L D V L+ +++ + L+ K++
Sbjct: 1411 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 847 EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905
+ E R A +E K +S ++A+ + + + E+L+
Sbjct: 1466 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 906 CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
++ + +L A + + ++ L +L+ + A + + + K Q E
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 963 TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010
D + + KR+++ Q+ E E E +++++ L KK E
Sbjct: 1579 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Score = 56.2 bits (134), Expect = 2e-07
Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%)
Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434
R++ + L++ E L+ H+S L L++ + Q A E L +
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398
Query: 435 AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480
E++ L +Q E+ A L + + + Q + QR K + K+ +L+
Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458
Query: 481 NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518
++ K A+ TK +S+AR +A+ +LER K E+ED +
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 519 RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575
D G+ + ++ LE+ +E+ T EL+ LQ + + + E N A + E+
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 576 ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
+ L + EE+ L+++L +T+L+ + ++ AK + + L A+
Sbjct: 1579 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 634 VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
I ++A+ QL + L S D + +T + LE + +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1692
Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
ED++ A L + +A + L S A + R A +A LEE
Sbjct: 1693 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1743
Query: 742 EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778
E E + AM + + K E+L + L K E
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803
Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSK 807
+ V + +T AA+E A++EE + +
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Score = 55.5 bits (132), Expect = 3e-07
Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%)
Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427
++ + +L R++ + +LE+ + + +L+G + +LE R++A
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 428 DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
L+A++ + +R+ ED A+ S EI A+ NE++ L+ ADL++
Sbjct: 1645 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1691
Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
++ +QA ++ E +EL SL G+ Q++ LE+ +A +
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1743
Query: 548 ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607
EL+ QG++E + + +L E + S A E L ++ ++ + KL
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803
Query: 608 TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638
E ++ K L + EQV Q+A
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Score = 52.0 bits (123), Expect = 3e-06
Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%)
Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
K E + ++ + + + + + ++ E +++ Q+ +LE + A +Q L+ +
Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 430 CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489
++ DE+ + K + ERK L+E+ S+L N A+ K
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1022
Query: 490 AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539
+T K SM + +V L++E+K + + L+R + EQ+ L++ LK
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588
+LA + ELQ L+ + N + ELE ++ L S A R
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 589 ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
EEL AL+ EL+DT A+ +E + +R+ + +KA ++ + Q++E
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Score = 46.2 bits (108), Expect = 2e-04
Identities = 50/203 (24%), Positives = 95/203 (46%), Gaps = 31/203 (15%)
Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
EK+ L E L +SG A L++ K + + QL+ + E + ++ ++A E
Sbjct: 1709 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 432 FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487
L +EL +R +K + + ++ER+ N++ SKL E S+ A L
Sbjct: 1768 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 488 KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQ----------------RK 527
K A++ +QV AR+ Q L+++ K+L++ L ++ D+ + ++
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Query: 528 TQEQLEVLESLKQELATSQRELQ 550
+ QLE E Q + ++R+LQ
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQ 1904
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 75.1 bits (183), Expect = 3e-13
Identities = 141/709 (19%), Positives = 267/709 (37%), Gaps = 124/709 (17%)
Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENM-------KTESQRVVLQLKGHVSELEADL 416
S ++EK + +L + A +E+ + E +++ +L G SEL+ +
Sbjct: 1037 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1096
Query: 417 AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS 476
EQQ ++ LRA+L E+ Q +L+ E + A Q L+E +
Sbjct: 1097 VEQQQRAEE-------LRAQLGRKE------EELQAALARAEDEGGARAQLLKSLREAQA 1143
Query: 477 ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ---RKTQEQLE 533
L + DL + TK R +LE + ELED+L+ + Q + ++ QE E
Sbjct: 1144 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1203
Query: 534 VLESLKQELATSQRELQVLQ-----------GSLETSAQSEANW-------AAEFAELEK 575
+ ++L++E + +Q L+ LE + + + W AE +EL
Sbjct: 1204 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1263
Query: 576 ERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVI 635
E SL + E+ L +LQ+ Q + E + + A+ ++ +A + +
Sbjct: 1264 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR------AQAELENV 1317
Query: 636 QDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695
ALN+ E + + L ST + E L++ LA + +
Sbjct: 1318 SGALNEAESKTI----RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM------- 1366
Query: 696 AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASL--------EEEGSLEN 747
+A A G E + A ++ GRE A L EE G+LE
Sbjct: 1367 -----EAEAAGLR-------EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1413
Query: 748 ADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSK 807
A A R + +A+ + L E T +E R+++ L
Sbjct: 1414 AGEEARRRAAREAEALTQRL-----------------AEKTETVDRLERGRRRLQQELD- 1455
Query: 808 SRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK-DLQREIVESGRGTASPKEFYAKNS 866
D + LE +++ + L+ K + R + E R A +E A+
Sbjct: 1456 ----DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1511
Query: 867 RWTEGLISASKAVGWGATVMVDAADLVVQG---RGKFEELMVCSHEIAASTAQLVAASKV 923
T L +A +L Q R + E L+ ++ S +L A +V
Sbjct: 1512 SLTRALEEEQEA----------REELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1561
Query: 924 KADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDS 983
+ AQ+ + + A + ++ ++ + + + +R+++
Sbjct: 1562 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1621
Query: 984 QVRVLELENELQKERQKL---------GELRKKHYELAGVAEGWEEGTE 1023
Q+R E+E + +++++ L GEL + ++A +G EE +
Sbjct: 1622 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1670
Score = 53.9 bits (128), Expect = 8e-07
Identities = 78/337 (23%), Positives = 141/337 (41%), Gaps = 58/337 (17%)
Query: 379 RLYREISGLKAQ----LENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLR 434
RL + LK Q L+ + QL + + E + E++ R A + L
Sbjct: 1589 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1648
Query: 435 AELDELRRQ-------REDTEKAQRSLS--------EIERKAQANEQRYSKLKEKYSELV 479
EL+EL+ Q +E+ K R + E+E + E+ +S+ +E L
Sbjct: 1649 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1708
Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLE-----------------REKKELEDSLERISD 522
A++LR E+ RQAQ D + EK++LE L ++
Sbjct: 1709 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL-- 1766
Query: 523 QGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF----AELEKERD 578
+E+LE +S + L R+L + SL T +E +++A+ +LE++
Sbjct: 1767 ------EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1820
Query: 579 SLVSGAAHREEELSALRK-ELQDTQLKLASTEESMCQLAKDQRKMLLVGSR-KAAEQVIQ 636
L + A K + + KLA EE QL ++ R+ +L G + AE+ ++
Sbjct: 1821 ELRGRLGEEDAGARARHKMTIAALESKLAQAEE---QLEQETRERILSGKLVRRAEKRLK 1877
Query: 637 DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673
+ + Q+EE + AD L + + ++QL++
Sbjct: 1878 EVVLQVEEERRV-----ADQLRDQLEKGNLRVKQLKR 1909
Score = 53.5 bits (127), Expect = 1e-06
Identities = 131/637 (20%), Positives = 248/637 (38%), Gaps = 113/637 (17%)
Query: 390 QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTE 448
+++ ++ +S R V +L+G V++LE E+ L +Q + E L AE +E R R +
Sbjct: 888 KVQELQQQSAREVGELQGRVAQLE---EERARLAEQLRAEAE-LCAEAEETRGRLAARKQ 943
Query: 449 KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ-VDLE 507
+ + +SE+E + E+ S+ + + +Q H L + E + Q + V E
Sbjct: 944 ELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 1002
Query: 508 REKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWA 567
+ K+ E+ L + DQ + ++E+ + + L + + + E + ++ + + EA A
Sbjct: 1003 AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1062
Query: 568 AEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGS 627
L KE +EL L++ L +L Q A++ R L
Sbjct: 1063 DMEDRLRKEEKG--------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL---G 1111
Query: 628 RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISG 687
RK E+ +Q AL + E+ G+ LL ++ + + + ++
Sbjct: 1112 RK--EEELQAALARAEDE-----GGARAQLLKSLREAQAALAEAQED------------- 1151
Query: 688 LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQ---YGRETLAYLASLEEEGS 744
L S+ +A T+A KQ G E A LE
Sbjct: 1152 ----------LESERVAR----------------TKAEKQRRDLGEELEALRGELE---- 1181
Query: 745 LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804
+ DST N ++++ E+ + EL +++E AA++ R +
Sbjct: 1182 -DTLDST---NAQQELRSKREQ--------EVTELKKTLEEETRIHEAAVQELRQRHGQA 1229
Query: 805 LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864
L G+ +LE R G A++ + +L+ E+ S TA +E +
Sbjct: 1230 L-----GELAEQLEQARRGKGAWEKTRLALEAEV---SELRAEL--SSLQTAR-QEGEQR 1278
Query: 865 NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924
R L G G +AA+ + + + + E + +E + T +L
Sbjct: 1279 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL------- 1331
Query: 925 ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQ 984
+ + S AQL A + + T +A ++ E + R++++ +
Sbjct: 1332 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL-----------REQLEEE 1380
Query: 985 VRVLE-LENELQKERQKLGELRKKHYELAGVAEGWEE 1020
E ELQ + +L E R++ E AG E EE
Sbjct: 1381 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEE 1417
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 75.1 bits (183), Expect = 3e-13
Identities = 141/709 (19%), Positives = 267/709 (37%), Gaps = 124/709 (17%)
Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENM-------KTESQRVVLQLKGHVSELEADL 416
S ++EK + +L + A +E+ + E +++ +L G SEL+ +
Sbjct: 1029 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1088
Query: 417 AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS 476
EQQ ++ LRA+L E+ Q +L+ E + A Q L+E +
Sbjct: 1089 VEQQQRAEE-------LRAQLGRKE------EELQAALARAEDEGGARAQLLKSLREAQA 1135
Query: 477 ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ---RKTQEQLE 533
L + DL + TK R +LE + ELED+L+ + Q + ++ QE E
Sbjct: 1136 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1195
Query: 534 VLESLKQELATSQRELQVLQ-----------GSLETSAQSEANW-------AAEFAELEK 575
+ ++L++E + +Q L+ LE + + + W AE +EL
Sbjct: 1196 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1255
Query: 576 ERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVI 635
E SL + E+ L +LQ+ Q + E + + A+ ++ +A + +
Sbjct: 1256 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR------AQAELENV 1309
Query: 636 QDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695
ALN+ E + + L ST + E L++ LA + +
Sbjct: 1310 SGALNEAESKTI----RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM------- 1358
Query: 696 AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASL--------EEEGSLEN 747
+A A G E + A ++ GRE A L EE G+LE
Sbjct: 1359 -----EAEAAGLR-------EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1405
Query: 748 ADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSK 807
A A R + +A+ + L E T +E R+++ L
Sbjct: 1406 AGEEARRRAAREAEALTQRL-----------------AEKTETVDRLERGRRRLQQELD- 1447
Query: 808 SRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK-DLQREIVESGRGTASPKEFYAKNS 866
D + LE +++ + L+ K + R + E R A +E A+
Sbjct: 1448 ----DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1503
Query: 867 RWTEGLISASKAVGWGATVMVDAADLVVQG---RGKFEELMVCSHEIAASTAQLVAASKV 923
T L +A +L Q R + E L+ ++ S +L A +V
Sbjct: 1504 SLTRALEEEQEA----------REELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1553
Query: 924 KADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDS 983
+ AQ+ + + A + ++ ++ + + + +R+++
Sbjct: 1554 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1613
Query: 984 QVRVLELENELQKERQKL---------GELRKKHYELAGVAEGWEEGTE 1023
Q+R E+E + +++++ L GEL + ++A +G EE +
Sbjct: 1614 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1662
Score = 53.9 bits (128), Expect = 8e-07
Identities = 78/337 (23%), Positives = 141/337 (41%), Gaps = 58/337 (17%)
Query: 379 RLYREISGLKAQ----LENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLR 434
RL + LK Q L+ + QL + + E + E++ R A + L
Sbjct: 1581 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1640
Query: 435 AELDELRRQ-------REDTEKAQRSLS--------EIERKAQANEQRYSKLKEKYSELV 479
EL+EL+ Q +E+ K R + E+E + E+ +S+ +E L
Sbjct: 1641 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1700
Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLE-----------------REKKELEDSLERISD 522
A++LR E+ RQAQ D + EK++LE L ++
Sbjct: 1701 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL-- 1758
Query: 523 QGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF----AELEKERD 578
+E+LE +S + L R+L + SL T +E +++A+ +LE++
Sbjct: 1759 ------EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1812
Query: 579 SLVSGAAHREEELSALRK-ELQDTQLKLASTEESMCQLAKDQRKMLLVGSR-KAAEQVIQ 636
L + A K + + KLA EE QL ++ R+ +L G + AE+ ++
Sbjct: 1813 ELRGRLGEEDAGARARHKMTIAALESKLAQAEE---QLEQETRERILSGKLVRRAEKRLK 1869
Query: 637 DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673
+ + Q+EE + AD L + + ++QL++
Sbjct: 1870 EVVLQVEEERRV-----ADQLRDQLEKGNLRVKQLKR 1901
Score = 53.5 bits (127), Expect = 1e-06
Identities = 131/637 (20%), Positives = 248/637 (38%), Gaps = 113/637 (17%)
Query: 390 QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTE 448
+++ ++ +S R V +L+G V++LE E+ L +Q + E L AE +E R R +
Sbjct: 880 KVQELQQQSAREVGELQGRVAQLE---EERARLAEQLRAEAE-LCAEAEETRGRLAARKQ 935
Query: 449 KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ-VDLE 507
+ + +SE+E + E+ S+ + + +Q H L + E + Q + V E
Sbjct: 936 ELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 994
Query: 508 REKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWA 567
+ K+ E+ L + DQ + ++E+ + + L + + + E + ++ + + EA A
Sbjct: 995 AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1054
Query: 568 AEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGS 627
L KE +EL L++ L +L Q A++ R L
Sbjct: 1055 DMEDRLRKEEKG--------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL---G 1103
Query: 628 RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISG 687
RK E+ +Q AL + E+ G+ LL ++ + + + ++
Sbjct: 1104 RK--EEELQAALARAEDE-----GGARAQLLKSLREAQAALAEAQED------------- 1143
Query: 688 LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQ---YGRETLAYLASLEEEGS 744
L S+ +A T+A KQ G E A LE
Sbjct: 1144 ----------LESERVAR----------------TKAEKQRRDLGEELEALRGELE---- 1173
Query: 745 LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804
+ DST N ++++ E+ + EL +++E AA++ R +
Sbjct: 1174 -DTLDST---NAQQELRSKREQ--------EVTELKKTLEEETRIHEAAVQELRQRHGQA 1221
Query: 805 LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864
L G+ +LE R G A++ + +L+ E+ S TA +E +
Sbjct: 1222 L-----GELAEQLEQARRGKGAWEKTRLALEAEV---SELRAEL--SSLQTAR-QEGEQR 1270
Query: 865 NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924
R L G G +AA+ + + + + E + +E + T +L
Sbjct: 1271 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL------- 1323
Query: 925 ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQ 984
+ + S AQL A + + T +A ++ E + R++++ +
Sbjct: 1324 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL-----------REQLEEE 1372
Query: 985 VRVLE-LENELQKERQKLGELRKKHYELAGVAEGWEE 1020
E ELQ + +L E R++ E AG E EE
Sbjct: 1373 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEE 1409
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 75.1 bits (183), Expect = 3e-13
Identities = 141/709 (19%), Positives = 267/709 (37%), Gaps = 124/709 (17%)
Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENM-------KTESQRVVLQLKGHVSELEADL 416
S ++EK + +L + A +E+ + E +++ +L G SEL+ +
Sbjct: 1070 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1129
Query: 417 AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS 476
EQQ ++ LRA+L E+ Q +L+ E + A Q L+E +
Sbjct: 1130 VEQQQRAEE-------LRAQLGRKE------EELQAALARAEDEGGARAQLLKSLREAQA 1176
Query: 477 ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ---RKTQEQLE 533
L + DL + TK R +LE + ELED+L+ + Q + ++ QE E
Sbjct: 1177 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1236
Query: 534 VLESLKQELATSQRELQVLQ-----------GSLETSAQSEANW-------AAEFAELEK 575
+ ++L++E + +Q L+ LE + + + W AE +EL
Sbjct: 1237 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1296
Query: 576 ERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVI 635
E SL + E+ L +LQ+ Q + E + + A+ ++ +A + +
Sbjct: 1297 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR------AQAELENV 1350
Query: 636 QDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695
ALN+ E + + L ST + E L++ LA + +
Sbjct: 1351 SGALNEAESKTI----RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM------- 1399
Query: 696 AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASL--------EEEGSLEN 747
+A A G E + A ++ GRE A L EE G+LE
Sbjct: 1400 -----EAEAAGLR-------EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1446
Query: 748 ADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSK 807
A A R + +A+ + L E T +E R+++ L
Sbjct: 1447 AGEEARRRAAREAEALTQRL-----------------AEKTETVDRLERGRRRLQQELD- 1488
Query: 808 SRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK-DLQREIVESGRGTASPKEFYAKNS 866
D + LE +++ + L+ K + R + E R A +E A+
Sbjct: 1489 ----DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1544
Query: 867 RWTEGLISASKAVGWGATVMVDAADLVVQG---RGKFEELMVCSHEIAASTAQLVAASKV 923
T L +A +L Q R + E L+ ++ S +L A +V
Sbjct: 1545 SLTRALEEEQEA----------REELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1594
Query: 924 KADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDS 983
+ AQ+ + + A + ++ ++ + + + +R+++
Sbjct: 1595 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1654
Query: 984 QVRVLELENELQKERQKL---------GELRKKHYELAGVAEGWEEGTE 1023
Q+R E+E + +++++ L GEL + ++A +G EE +
Sbjct: 1655 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1703
Score = 53.9 bits (128), Expect = 8e-07
Identities = 78/337 (23%), Positives = 141/337 (41%), Gaps = 58/337 (17%)
Query: 379 RLYREISGLKAQ----LENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLR 434
RL + LK Q L+ + QL + + E + E++ R A + L
Sbjct: 1622 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1681
Query: 435 AELDELRRQ-------REDTEKAQRSLS--------EIERKAQANEQRYSKLKEKYSELV 479
EL+EL+ Q +E+ K R + E+E + E+ +S+ +E L
Sbjct: 1682 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1741
Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLE-----------------REKKELEDSLERISD 522
A++LR E+ RQAQ D + EK++LE L ++
Sbjct: 1742 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL-- 1799
Query: 523 QGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF----AELEKERD 578
+E+LE +S + L R+L + SL T +E +++A+ +LE++
Sbjct: 1800 ------EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1853
Query: 579 SLVSGAAHREEELSALRK-ELQDTQLKLASTEESMCQLAKDQRKMLLVGSR-KAAEQVIQ 636
L + A K + + KLA EE QL ++ R+ +L G + AE+ ++
Sbjct: 1854 ELRGRLGEEDAGARARHKMTIAALESKLAQAEE---QLEQETRERILSGKLVRRAEKRLK 1910
Query: 637 DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673
+ + Q+EE + AD L + + ++QL++
Sbjct: 1911 EVVLQVEEERRV-----ADQLRDQLEKGNLRVKQLKR 1942
Score = 53.5 bits (127), Expect = 1e-06
Identities = 131/637 (20%), Positives = 248/637 (38%), Gaps = 113/637 (17%)
Query: 390 QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTE 448
+++ ++ +S R V +L+G V++LE E+ L +Q + E L AE +E R R +
Sbjct: 921 KVQELQQQSAREVGELQGRVAQLE---EERARLAEQLRAEAE-LCAEAEETRGRLAARKQ 976
Query: 449 KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ-VDLE 507
+ + +SE+E + E+ S+ + + +Q H L + E + Q + V E
Sbjct: 977 ELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 1035
Query: 508 REKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWA 567
+ K+ E+ L + DQ + ++E+ + + L + + + E + ++ + + EA A
Sbjct: 1036 AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1095
Query: 568 AEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGS 627
L KE +EL L++ L +L Q A++ R L
Sbjct: 1096 DMEDRLRKEEKG--------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL---G 1144
Query: 628 RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISG 687
RK E+ +Q AL + E+ G+ LL ++ + + + ++
Sbjct: 1145 RK--EEELQAALARAEDE-----GGARAQLLKSLREAQAALAEAQED------------- 1184
Query: 688 LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQ---YGRETLAYLASLEEEGS 744
L S+ +A T+A KQ G E A LE
Sbjct: 1185 ----------LESERVAR----------------TKAEKQRRDLGEELEALRGELE---- 1214
Query: 745 LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804
+ DST N ++++ E+ + EL +++E AA++ R +
Sbjct: 1215 -DTLDST---NAQQELRSKREQ--------EVTELKKTLEEETRIHEAAVQELRQRHGQA 1262
Query: 805 LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864
L G+ +LE R G A++ + +L+ E+ S TA +E +
Sbjct: 1263 L-----GELAEQLEQARRGKGAWEKTRLALEAEV---SELRAEL--SSLQTAR-QEGEQR 1311
Query: 865 NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924
R L G G +AA+ + + + + E + +E + T +L
Sbjct: 1312 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL------- 1364
Query: 925 ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQ 984
+ + S AQL A + + T +A ++ E + R++++ +
Sbjct: 1365 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL-----------REQLEEE 1413
Query: 985 VRVLE-LENELQKERQKLGELRKKHYELAGVAEGWEE 1020
E ELQ + +L E R++ E AG E EE
Sbjct: 1414 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEE 1450
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 75.1 bits (183), Expect = 3e-13
Identities = 148/708 (20%), Positives = 281/708 (39%), Gaps = 108/708 (15%)
Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437
E RE+ L++ E + E + L+ V++ +A+ Q+ + QAA E LR +
Sbjct: 585 EDAQREVQRLRSANELLSREKSNLAHSLQ--VAQQQAEELRQEREKLQAAQ--EELRRQR 640
Query: 438 DELRRQREDT-----------EKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLL 486
D L ++ED E++ R L ++E K + +++E S L
Sbjct: 641 DRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ 700
Query: 487 RKNAEVTKQVSMARQAQVDLE-------REKKELEDSLERISDQGQRKTQEQLEVLESLK 539
+ AEV + ++ A +V+LE E+ L+DSL ++S + Q++L+ L
Sbjct: 701 AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLD----LN 756
Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAE------LEKE--RDSLVSGAAHREEEL 591
+ +A + E LQG + A+ EA A E E LE+E R L E+
Sbjct: 757 RLVAQLEEEKSALQGR-QRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ 815
Query: 592 SALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCA 651
AL ++L + + + +E + QL++ L G + EQ ++A Q
Sbjct: 816 EALEQQLPTLRHERSQLQEQLAQLSRQ-----LSGREQELEQARREAQRQ---------- 860
Query: 652 GSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCL 711
+E LE++ + A ++ +GL ++ L+A T L
Sbjct: 861 ----------------VEALERAAREKEALAKEHAGL--AVQLVAAEREGRTLSEEATRL 902
Query: 712 RAPPEPAD-SLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPR 770
R E + SL E +Q LA LE A+ A+ L+K GE R
Sbjct: 903 RLEKEALEGSLFEVQRQ--------LAQLEARREQLEAEGQAL--LLAKETLTGELAGLR 952
Query: 771 GLDIKQEELGDLVDKEMAA---------TSAAIETATARIEEMLSKSRAGDTGVKLEVNE 821
I +E L DKE+ A A++ A EE L + + E+
Sbjct: 953 QQIIATQEKASL-DKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011
Query: 822 RILGCCTSLMQAIQVLIVA----SKDLQREIV------ESGRGTASPKEFYAKNSRWTEG 871
+ L + + L+ ++L EI + G A ++ A + + +E
Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEK 1071
Query: 872 LISASKAVGWG---ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928
+ K +G AT+ ++ + + E+ + + + L A + A
Sbjct: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH 1131
Query: 929 SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988
+ + +LQ+ +R + + + ++Q+ ++ ++R+ +++Q ++
Sbjct: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLED------ARDGLRRELLEAQRKLR 1185
Query: 989 ELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEK 1036
E + + +RQ+ GELR+ E A E E +++ +E+
Sbjct: 1186 ESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESER 1233
Score = 73.2 bits (178), Expect = 1e-12
Identities = 112/452 (24%), Positives = 189/452 (41%), Gaps = 60/452 (13%)
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
+ +L R++SG + +LE + E+QR V L+ E EA E L Q R
Sbjct: 836 LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 895
Query: 437 LDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQV 496
+E R R + E + SL E++R+ E R +L+ + A LL K +T ++
Sbjct: 896 SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLE------AEGQALLLAKET-LTGEL 948
Query: 497 SMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSL 556
+ RQ Q+ +EK L+ L Q+ Q + E SL+++ A + +LQ LQ
Sbjct: 949 AGLRQ-QIIATQEKASLDKEL-----MAQKLVQAEREAQASLREQRAAHEEDLQRLQ--- 999
Query: 557 ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLA 616
+ EA W ELE ER L S +EEL A R E + +L S E + Q
Sbjct: 1000 ---REKEAAW----RELEAERAQLQSQLQREQEELLA-RLEAEKEEL---SEEIAALQQE 1048
Query: 617 KDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWS 676
+D+ +L AE Q AL+ E ++ L+ T S+++ ++E+
Sbjct: 1049 RDEGLLL-------AESEKQQALSLKESEK----TALSEKLMGTRHSLATISLEMERQKR 1097
Query: 677 QYLACPEDISGLLHSIT-----LLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRE 731
+ E ++++T L A A AH + L E + G++
Sbjct: 1098 DAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA---------QEVRRLQEQARDLGKQ 1148
Query: 732 TLAYLASLEEEGS----LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDK-- 785
+ L EE + LE+A R L + + E G +++++E G+L
Sbjct: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRES--QEGREVQRQEAGELRRSLG 1206
Query: 786 EMAATSAAIETATARIEEMLSKSRAGDTGVKL 817
E A A+ + + + K+ + +KL
Sbjct: 1207 EGAKEREALRRSNEELRSAVKKAESERISLKL 1238
Score = 62.8 bits (151), Expect = 2e-09
Identities = 121/613 (19%), Positives = 246/613 (40%), Gaps = 71/613 (11%)
Query: 437 LDELRRQREDTEKAQRSLSE----IERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492
L LR+Q D+E +R+L E + K Q + + + L + L R+ + +
Sbjct: 549 LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNL 608
Query: 493 TKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLES---LKQELATSQREL 549
+ +A+Q +L +E+++L+ + E + Q R +EQ + ++ +++EL S R+L
Sbjct: 609 AHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQL 668
Query: 550 QVLQG--------------SLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALR 595
+ L+G +L + AE AE+ + +G E ++ LR
Sbjct: 669 EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
Query: 596 KE---LQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAG 652
E LQD+ KL++ ES+ Q D + LV + + +Q Q E+ ++
Sbjct: 729 AEEASLQDSLSKLSALNESLAQDKLDLNR--LVAQLEEEKSALQGRQRQAEQEATVAREE 786
Query: 653 SADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLR 712
E+LE+ + + + G L +A +A+ T
Sbjct: 787 Q---------------ERLEELRLEQEVARQGLEGSLR----VAEQAQEALEQQLPTLRH 827
Query: 713 APPEPADSLTEACKQY-GRETLAYLASLEEEGSLENADSTAM-RNCLSKIKA-IGEELLP 769
+ + L + +Q GRE A E + +E + A + L+K A + +L+
Sbjct: 828 ERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVA 887
Query: 770 ---RGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILG- 825
G + +E ++KE A+E + ++ L++ A ++ E +L
Sbjct: 888 AEREGRTLSEEATRLRLEKE------ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK 941
Query: 826 -CCTSLMQAIQVLIVASKD--------LQREIVESGR-GTASPKEFYAKNSRWTEGLISA 875
T + ++ I+A+++ + +++V++ R AS +E A + + L
Sbjct: 942 ETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRL-QR 1000
Query: 876 SKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQL 935
K W + + A L Q + + EEL+ ++ +AA + + D+
Sbjct: 1001 EKEAAW-RELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESE 1059
Query: 936 QQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQ 995
+Q + + ++ ++ + G T +++ RQE D V L +EL+
Sbjct: 1060 KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST-VNALTSELR 1118
Query: 996 KERQKLGELRKKH 1008
R + E H
Sbjct: 1119 DLRAQREEAAAAH 1131
Score = 56.6 bits (135), Expect = 1e-07
Identities = 58/268 (21%), Positives = 104/268 (38%), Gaps = 14/268 (5%)
Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437
+ L + S L QL M+ E + + +L+ +AE + R+ ++AEL
Sbjct: 1526 DELRTQTSALNRQLAEMEAERDSATSRAR----QLQKAVAESEEARRSVDGRLSGVQAEL 1581
Query: 438 ----DELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493
+ +RR + ++ +ER QA E +EK S++ N L +
Sbjct: 1582 ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLK 1641
Query: 494 KQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQ 553
+ + + V LE +++ LE L+R S G + Q + L+ L + +V
Sbjct: 1642 EVLDASESRTVKLELQRRSLEGELQR-SRLGLSDREAQAQALQDRVDSLQRQVADSEVKA 1700
Query: 554 GSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMC 613
G+L+ + + A+ E E V G + SA +D L L
Sbjct: 1701 GTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHL-----QKA 1755
Query: 614 QLAKDQRKMLLVGSRKAAEQVIQDALNQ 641
A + + +L AA Q + +A Q
Sbjct: 1756 LTACEHDRQVLQERLDAARQALSEARKQ 1783
Score = 55.5 bits (132), Expect = 3e-07
Identities = 139/678 (20%), Positives = 249/678 (36%), Gaps = 92/678 (13%)
Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
RE L+ QL ++ L+ + E + L E Q R+ + LR L E
Sbjct: 1154 REAEELRTQLRLLEDARDG----LRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGA 1209
Query: 442 RQREDTEKAQRSLSEIERKAQAN-----------EQRYSKLKEKYSELVQNHADLLRKNA 490
++RE ++ L +KA++ EQ+ + L+E + + + +L
Sbjct: 1210 KEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ 1269
Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQ----------GQRKTQEQLE------- 533
EV + AR+ +L R+ K L+ R+ + G+R +E
Sbjct: 1270 EVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQ 1329
Query: 534 -------VLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAH 586
LE ++QEL +QR+LQ +G T + E EK++ + A
Sbjct: 1330 RLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQ---LDHARG 1386
Query: 587 REEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
E +L A R E + L+L++ E L + ++ + R+AAE + + L
Sbjct: 1387 LELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEV--QRRAAEAQLGGLRSALRRG- 1443
Query: 647 LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706
L + S + S ++ GL TL S + G
Sbjct: 1444 -----------LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492
Query: 707 ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
T P D EA + RE L L S + E ++A+ L++++A +
Sbjct: 1493 PAT----SPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDS 1548
Query: 767 LLPRGLDIKQ-----EELGDLVDKEMAATSA--AIETATARIEEMLSKSRAGDTGV---K 816
R +++ EE VD ++ A A++ + R E ++
Sbjct: 1549 ATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERS 1608
Query: 817 LEVNERILGCC---TSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLI 873
L+ E L S M+A + + K +E++++ E R EG +
Sbjct: 1609 LQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLEL---QRRSLEGEL 1665
Query: 874 SASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLA 933
S+ +G +A +Q R + V E+ A T QL ++ + LA
Sbjct: 1666 QRSR-LGLSDR---EAQAQALQDRVDSLQRQVADSEVKAGTLQLT------VERLNGALA 1715
Query: 934 QLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENE 993
+++++ + G+ + + + T D + + E D QV L+
Sbjct: 1716 KVEESEGALRDKVRGLTEALAQSSASLNST--RDKNLHLQKALTACEHDRQV----LQER 1769
Query: 994 LQKERQKLGELRKKHYEL 1011
L RQ L E RK+ L
Sbjct: 1770 LDAARQALSEARKQSSSL 1787
Score = 53.9 bits (128), Expect = 8e-07
Identities = 60/288 (20%), Positives = 124/288 (43%), Gaps = 22/288 (7%)
Query: 378 ERLYREISGLKAQLEN-MKTESQRVVLQLKGHVSELEADLAEQQHLRQQA-----ADDCE 431
E +RE+ +AQL++ ++ E + ++ +L+ EL ++A Q R + ++ +
Sbjct: 1003 EAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQ 1062
Query: 432 FLRAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
L + E E + SL+ E+ER+ + + R + + + L DL
Sbjct: 1063 ALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA 1122
Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
+ E + + + R+ + DS R +++ + + + + + L++EL +QR
Sbjct: 1123 QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
Query: 548 ELQVLQGSLETSAQSEANWAAEFAELEKERDS-------LVSGAAHREEELSALRKELQD 600
+L+ Q E Q E KER++ L S E E +L+ +D
Sbjct: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1242
Query: 601 TQLKLASTEESMCQLAKDQRKML-----LVGSRKAAEQVIQDALNQLE 643
+ KLA EE+ + K+ ++ + SR A + +Q+ Q++
Sbjct: 1243 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290
Score = 53.1 bits (126), Expect = 1e-06
Identities = 56/276 (20%), Positives = 125/276 (45%), Gaps = 26/276 (9%)
Query: 372 EKDHLIERLYREISGLKAQLENMKTES---QRVVLQLKGHVSELEADLAEQQHLRQQAAD 428
+++ + L + L+ Q+ + + ++ Q V +L G ++++E + LR +
Sbjct: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES---EGALRDKVRG 1730
Query: 429 DCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRK 488
E L L R+ Q++L+ E Q ++R ++ SE ++
Sbjct: 1731 LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA-------RKQ 1783
Query: 489 NAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRE 548
++ + +QV R DLE ++ E E L+++ + +++ + + L ++ Q+L +R
Sbjct: 1784 SSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTV-QKLQDERRL 1842
Query: 549 LQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAST 608
LQ GSL+ + A+LE E+ + A E++ ALR+ L + + +
Sbjct: 1843 LQERLGSLQRA----------LAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS 1892
Query: 609 EESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
E +L+ ++ + L + AE + +A Q+++
Sbjct: 1893 HEDTVRLSAEKGR--LDRTLTGAELELAEAQRQIQQ 1926
Score = 52.4 bits (124), Expect = 2e-06
Identities = 50/217 (23%), Positives = 96/217 (44%), Gaps = 22/217 (10%)
Query: 397 ESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSE 456
E R VLQ + + L+E + + + LR E+ +L QR + E + L E
Sbjct: 1760 EHDRQVLQER--LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLRE 1817
Query: 457 IERKAQANE----QRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKE 512
+ R+ Q E KL+++ L + L R A++ + ++ + LE+++
Sbjct: 1818 VLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVA 1877
Query: 513 LEDSLERISDQGQRKTQEQLEV----------LESLKQELATSQRELQVLQGSL------ 556
L +L+++ + R ++ + + L + ELA +QR++Q L+ +
Sbjct: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQS 1937
Query: 557 ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593
+ AQ E + + EL++E + L S A E L A
Sbjct: 1938 HSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEA 1974
Score = 48.9 bits (115), Expect = 2e-05
Identities = 68/308 (22%), Positives = 121/308 (39%), Gaps = 47/308 (15%)
Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSE--LEADLAEQQHLRQQAAD- 428
E+ L +L RE L A+LE K E + L+ E L A+ +QQ L + ++
Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEK 1071
Query: 429 -----------------DCEFLRAELDELRRQREDTEKAQRSLSEI-------ERKAQAN 464
E R + D RQ +D SE+ E A A+
Sbjct: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH 1131
Query: 465 EQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQG 524
Q +L+E+ +L + LR+ E+ Q+ + A+ L RE E + L +
Sbjct: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR 1191
Query: 525 QRKTQEQLEVLESL-------------KQELATSQRELQVLQGSLETSAQSEANWAAEFA 571
+ + QE E+ SL +EL ++ ++ + + SL+ + + + A
Sbjct: 1192 EVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLE 1251
Query: 572 ELE----KERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM---LL 624
E KE L +G E R+ELQ+ + ++ + +L ++ ++ L
Sbjct: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
Query: 625 VGSRKAAE 632
+G R E
Sbjct: 1312 LGERAEKE 1319
Score = 44.7 bits (104), Expect = 5e-04
Identities = 48/193 (24%), Positives = 91/193 (47%), Gaps = 20/193 (10%)
Query: 376 LIERLYREISGLKAQLENM-KTESQRVVLQ-----LKGHVSELEADLAEQQHLRQQAADD 429
L E L + G A L + K + +R +LQ L+ +++LEA+ E + + D
Sbjct: 1815 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKD 1874
Query: 430 CEFLRAELDELRRQR----EDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485
LR LD++ R++ EDT + ++R E +L E ++ Q A +
Sbjct: 1875 RVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAEL---ELAEAQRQIQQLEAQV 1931
Query: 486 LRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE-SLKQELAT 544
+ V +Q Q +VD ++++ EL+ +ER+ Q +T+ LE E + +Q +
Sbjct: 1932 V-----VLEQSHSPAQLEVDAQQQQLELQQEVERLR-SAQAQTERTLEARERAHRQRVRG 1985
Query: 545 SQRELQVLQGSLE 557
+ ++ L+G L+
Sbjct: 1986 LEEQVSTLKGQLQ 1998
Score = 39.7 bits (91), Expect = 0.015
Identities = 160/795 (20%), Positives = 298/795 (37%), Gaps = 162/795 (20%)
Query: 380 LYREISGLKAQLENMKTESQRVVLQLKGHVSEL-----EADLAEQQHLR------QQAAD 428
L+R++ G + + +K ++R +LQL G ++ EA L LR + A +
Sbjct: 299 LWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALE 358
Query: 429 DCEFLRAELDELRRQREDTEK--AQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLL 486
L+A+L+E R + EK AQ+ + KA + R ++L L + + +
Sbjct: 359 KQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLS-ARVTELGLAVKRLEKQNLEKD 417
Query: 487 RKNAEVTKQV----SMARQAQVDLEREKKE-LEDSLERISDQGQRKTQEQLEVLESLKQE 541
+ N ++T+++ S+ Q Q LE E E L+ +L ++ Q E L ++
Sbjct: 418 QVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLA-QAVLSDSESGVQLSGSERT 476
Query: 542 LATSQRELQVLQGSLETS-------------------AQSEANWAAEFAELEKERDSLVS 582
S L+ L G S A S+++ A +R V
Sbjct: 477 ADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQ 536
Query: 583 GAAHREEE----LSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638
R E L LRK+L D++ + + EE + Q +D+ G+ +A E ++
Sbjct: 537 DMRGRYEASQDLLGTLRKQLSDSESERRALEEQL-QRLRDKTD----GAMQAHEDAQREV 591
Query: 639 LNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698
L+S S +L ++ E+L + + A E+ L L
Sbjct: 592 QRLRSANELLSREKS--NLAHSLQVAQQQAEELRQEREKLQAAQEE---LRRQRDRLEEE 646
Query: 699 TSDAIAHGA--------------------TTCLRAPPEPADSLTEACKQYG-----RETL 733
DA+ GA + + E ++L+ A Q + +
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706
Query: 734 AYLASLEEEGSLE--------NADSTAMRNCLSKIKAIGEELLPRGLDIK------QEEL 779
A + E G +E A+ ++++ LSK+ A+ E L LD+ +EE
Sbjct: 707 AEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEK 766
Query: 780 GDLVDKEMAATSAA--IETATARIEEMLSKSRAGDTGV---------------------- 815
L ++ A A R+EE+ + G+
Sbjct: 767 SALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLR 826
Query: 816 --KLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK-NSRWTEGL 872
+ ++ E++ L Q L A ++ QR+ VE+ A KE AK ++ L
Sbjct: 827 HERSQLQEQLAQLSRQLSGREQELEQARREAQRQ-VEALERAAREKEALAKEHAGLAVQL 885
Query: 873 ISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIA--------------------- 911
++A + G T+ +A L ++ L ++A
Sbjct: 886 VAAERE---GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942
Query: 912 ------ASTAQLVAASKVKADKDSPNLAQ-LQQASRGVNQATAGVVASTISGKSQIEETD 964
A Q + A++ KA D +AQ L QA R +A A + + + ++
Sbjct: 943 TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER---EAQASLREQRAAHEEDLQRLQ 999
Query: 965 NMDFSSMTLTQIKRQEMDSQVR--VLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022
++ + +R ++ SQ++ EL L+ E+++L E E+A + + +EG
Sbjct: 1000 REKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSE------EIAALQQERDEGL 1053
Query: 1023 EASPPTLQEVVTEKE 1037
+ Q+ ++ KE
Sbjct: 1054 LLAESEKQQALSLKE 1068
Score = 38.5 bits (88), Expect = 0.033
Identities = 45/188 (23%), Positives = 86/188 (45%), Gaps = 18/188 (9%)
Query: 372 EKDHLIERLYREISGLKAQLENMKTE--------SQRVVLQLKGHVSELEADLAEQQHLR 423
E++ L+++ + L AQ + E S+R+ L+ ELE E + L
Sbjct: 81 EENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQ--EPRGLV 138
Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
+Q+ + L+ E RR+ + ++ Q+ +++ ++ Q +Y K++ SEL Q
Sbjct: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQY---KKRCSELEQQ-- 193
Query: 484 DLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ--RKTQEQLEVLESLKQE 541
LL ++ E+ +Q + DLE LE+ +R + Q +EQL+ S Q
Sbjct: 194 -LLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQA 252
Query: 542 LATSQREL 549
L+ R++
Sbjct: 253 LSEDIRKV 260
Score = 36.2 bits (82), Expect = 0.16
Identities = 31/108 (28%), Positives = 54/108 (50%), Gaps = 16/108 (14%)
Query: 383 EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442
E+ +AQ + + E+Q VVL+ ++LE D A+QQ L L+ E++ LR
Sbjct: 1914 ELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVD-AQQQQLE---------LQQEVERLRS 1963
Query: 443 QREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
+ TE+ +E + +A+ QR L+E+ S L LR+++
Sbjct: 1964 AQAQTERT------LEARERAHRQRVRGLEEQVSTLKGQLQQELRRSS 2005
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 75.1 bits (183), Expect = 3e-13
Identities = 85/341 (24%), Positives = 146/341 (42%), Gaps = 56/341 (16%)
Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437
E+L RE L A+ ++K + + + + G ++ + AE Q + Q + D A L
Sbjct: 1482 EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD----EASL 1537
Query: 438 DELRRQREDTE-KAQRSLSEIERKA---QANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493
++++Q D E K + E++ +A Q EQ +L+ + + Q H+ + E
Sbjct: 1538 AKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV 1597
Query: 494 KQVSMA-----RQAQVDLE----------REKKELEDSLERISDQGQRKTQEQLE----- 533
++ + +Q +V LE REK+ELE L +SDQ R+ E +
Sbjct: 1598 EEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKD 1657
Query: 534 -------------VLESLKQELATSQRELQVLQGSLETS-------AQSEANWAAEFAEL 573
+L+ LK A S+RE+ L+ LE S ++ E +L
Sbjct: 1658 LKRTKALLADAQLMLDHLKNS-APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716
Query: 574 EKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
+ D + EE+LS L++E + Q +L +E M +L K + + SR A+
Sbjct: 1717 HLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ- 1775
Query: 634 VIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKS 674
I D QLEE L + ++ S +E LE+S
Sbjct: 1776 -INDLQAQLEE-----ANKEKQELQEKLQALQSQVEFLEQS 1810
Score = 69.3 bits (168), Expect = 2e-11
Identities = 61/283 (21%), Positives = 134/283 (47%), Gaps = 17/283 (6%)
Query: 361 NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTE--SQRVVLQLKGHVSELEADLAE 418
+F S+ + KD ++R ++ + L+++K S+R + QLK + E E A
Sbjct: 1647 DFESEKRLRKD-----LKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAA 1701
Query: 419 QQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSEL 478
R+ + E L ++D++ + + E+ LS ++R+ + R + +E +EL
Sbjct: 1702 AVKARKAMEVEIEDLHLQIDDIAKAKTALEE---QLSRLQREKNEIQNRLEEDQEDMNEL 1758
Query: 479 VQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538
++ H + + + Q++ + + +EK+EL++ L+ + Q Q + EQ V +SL
Sbjct: 1759 MKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL--QSQVEFLEQSMVDKSL 1816
Query: 539 KQELATSQRELQVLQGSLETSAQSEANWAAEFAE----LEKERDSLVSGAAHREEELSAL 594
REL+ T + + A+ E L +ERD ++ +E+ L
Sbjct: 1817 VSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRL 1876
Query: 595 RKELQDTQLKLASTEESMCQLAKDQRKMLL-VGSRKAAEQVIQ 636
+++L+DT+ ++ + ++ + ++ + + S +AA Q +Q
Sbjct: 1877 QRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919
Score = 62.8 bits (151), Expect = 2e-09
Identities = 67/261 (25%), Positives = 116/261 (44%), Gaps = 25/261 (9%)
Query: 378 ERLYREISGLKAQL----ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL 433
ER RE+ K +L E+ Q+ QL+ + +L+AD E Q QQ C+ L
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRL 1435
Query: 434 RAELDELRRQRE-------DTEKAQR----SLSEIERKAQANEQRYSKLKEKYSELVQNH 482
AEL + + E + EK QR LS+ +AQ + + KL+ + L+
Sbjct: 1436 TAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEA 1495
Query: 483 ADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQEL 542
L ++ E ++ Q V LE E +++ S E + K ++QL LE+ ++
Sbjct: 1496 FSLKQQLEEKDMDIAGFTQKVVSLEAELQDI-SSQESKDEASLAKVKKQLRDLEA---KV 1551
Query: 543 ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ 602
+ EL G+++ Q++ E+E+ R + R+EE+ R Q Q
Sbjct: 1552 KDQEEELDEQAGTIQMLEQAKLRLE---MEMERMRQTHSKEMESRDEEVEEAR---QSCQ 1605
Query: 603 LKLASTEESMCQLAKDQRKML 623
KL E + + +D++K+L
Sbjct: 1606 KKLKQMEVQLEEEYEDKQKVL 1626
Score = 52.8 bits (125), Expect = 2e-06
Identities = 54/235 (22%), Positives = 107/235 (45%), Gaps = 20/235 (8%)
Query: 383 EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442
+I+ K LE + QR +++ + E + D+ E + A A++++L+
Sbjct: 1722 DIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQA 1781
Query: 443 QREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQA 502
Q E+ K ++ L E K QA L+ + L Q+ D + V++Q + R+
Sbjct: 1782 QLEEANKEKQELQE---KLQA-------LQSQVEFLEQSMVD----KSLVSRQEAKIREL 1827
Query: 503 QVDLEREK---KELEDSLERISDQGQRKTQEQLEVLESLKQELATS---QRELQVLQGSL 556
+ LE E+ K LE R+ + ++ T+E+ + + + +E + QR+L+ + +
Sbjct: 1828 ETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEM 1887
Query: 557 ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEES 611
A+ EA + + ELE + +SL + + +L K + D Q + ES
Sbjct: 1888 GELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMES 1942
Score = 49.3 bits (116), Expect = 2e-05
Identities = 135/695 (19%), Positives = 253/695 (36%), Gaps = 124/695 (17%)
Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
E +R + +E+++ R EKA++ +E+ + E R S+L SEL R
Sbjct: 1254 EQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELT---SELTDE-----RNTG 1305
Query: 491 EVTKQVSMARQAQ-VDLEREKKELEDSLERISDQGQRKTQEQLEVLES------------ 537
E Q+ A A+ + E+E KEL+ + + Q + ++EV+E+
Sbjct: 1306 ESASQLLDAETAERLRAEKEMKELQTQYDALKKQME---VMEMEVMEARLIRAAEINGEV 1362
Query: 538 ----------LKQELA------TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLV 581
LK E A T +R Q + LE Q++ +L+ + +
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQ 1422
Query: 582 SGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM---LLVGSRKAAEQVIQDA 638
+++ L ELQDT+L L + +L K QR+ L +A + +Q
Sbjct: 1423 RALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQRE 1482
Query: 639 LNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698
Q E+ D LL+ S+ +E+ + + + + L I+
Sbjct: 1483 KLQREK----------DMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532
Query: 699 TSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADST------- 751
++A + D E +Q G + A L E +E T
Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMES 1592
Query: 752 -------AMRNCLSKIKAIGEEL------------LPRGLDIKQEELGDLVD-------- 784
A ++C K+K + +L R L+ K L D V+
Sbjct: 1593 RDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEK 1652
Query: 785 ---KEMAATSAAIETATARIEEML----SKSRAGDTGVKLEVNERILGCCTSLMQAIQVL 837
K++ T A + A ++ + SK +LE +E C + ++A + +
Sbjct: 1653 RLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESE---FTCAAAVKARKAM 1709
Query: 838 IVASKDLQREIVESGRGTASPKEFYAKNSR---------------WTEGLISASKAVGWG 882
V +DL +I + + + +E ++ R E + AV
Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1769
Query: 883 ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGV 942
+ + DL Q +E ++ A +Q+ + DK +L Q+A +
Sbjct: 1770 SRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDK---SLVSRQEAK--I 1824
Query: 943 NQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLE----LENELQKER 998
+ + K + + LT+ + Q + ++ R E L+ +L+ +
Sbjct: 1825 RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1884
Query: 999 QKLGELRKKHYELAGVAEGWE---EGTEASPPTLQ 1030
+++GEL +K E + E E EA+ +LQ
Sbjct: 1885 EEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 75.1 bits (183), Expect = 3e-13
Identities = 85/341 (24%), Positives = 146/341 (42%), Gaps = 56/341 (16%)
Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437
E+L RE L A+ ++K + + + + G ++ + AE Q + Q + D A L
Sbjct: 1482 EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD----EASL 1537
Query: 438 DELRRQREDTE-KAQRSLSEIERKA---QANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493
++++Q D E K + E++ +A Q EQ +L+ + + Q H+ + E
Sbjct: 1538 AKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV 1597
Query: 494 KQVSMA-----RQAQVDLE----------REKKELEDSLERISDQGQRKTQEQLE----- 533
++ + +Q +V LE REK+ELE L +SDQ R+ E +
Sbjct: 1598 EEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKD 1657
Query: 534 -------------VLESLKQELATSQRELQVLQGSLETS-------AQSEANWAAEFAEL 573
+L+ LK A S+RE+ L+ LE S ++ E +L
Sbjct: 1658 LKRTKALLADAQLMLDHLKNS-APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716
Query: 574 EKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
+ D + EE+LS L++E + Q +L +E M +L K + + SR A+
Sbjct: 1717 HLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ- 1775
Query: 634 VIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKS 674
I D QLEE L + ++ S +E LE+S
Sbjct: 1776 -INDLQAQLEE-----ANKEKQELQEKLQALQSQVEFLEQS 1810
Score = 69.3 bits (168), Expect = 2e-11
Identities = 61/283 (21%), Positives = 134/283 (47%), Gaps = 17/283 (6%)
Query: 361 NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTE--SQRVVLQLKGHVSELEADLAE 418
+F S+ + KD ++R ++ + L+++K S+R + QLK + E E A
Sbjct: 1647 DFESEKRLRKD-----LKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAA 1701
Query: 419 QQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSEL 478
R+ + E L ++D++ + + E+ LS ++R+ + R + +E +EL
Sbjct: 1702 AVKARKAMEVEIEDLHLQIDDIAKAKTALEE---QLSRLQREKNEIQNRLEEDQEDMNEL 1758
Query: 479 VQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538
++ H + + + Q++ + + +EK+EL++ L+ + Q Q + EQ V +SL
Sbjct: 1759 MKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL--QSQVEFLEQSMVDKSL 1816
Query: 539 KQELATSQRELQVLQGSLETSAQSEANWAAEFAE----LEKERDSLVSGAAHREEELSAL 594
REL+ T + + A+ E L +ERD ++ +E+ L
Sbjct: 1817 VSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRL 1876
Query: 595 RKELQDTQLKLASTEESMCQLAKDQRKMLL-VGSRKAAEQVIQ 636
+++L+DT+ ++ + ++ + ++ + + S +AA Q +Q
Sbjct: 1877 QRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919
Score = 62.8 bits (151), Expect = 2e-09
Identities = 67/261 (25%), Positives = 116/261 (44%), Gaps = 25/261 (9%)
Query: 378 ERLYREISGLKAQL----ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL 433
ER RE+ K +L E+ Q+ QL+ + +L+AD E Q QQ C+ L
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRL 1435
Query: 434 RAELDELRRQRE-------DTEKAQR----SLSEIERKAQANEQRYSKLKEKYSELVQNH 482
AEL + + E + EK QR LS+ +AQ + + KL+ + L+
Sbjct: 1436 TAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEA 1495
Query: 483 ADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQEL 542
L ++ E ++ Q V LE E +++ S E + K ++QL LE+ ++
Sbjct: 1496 FSLKQQLEEKDMDIAGFTQKVVSLEAELQDI-SSQESKDEASLAKVKKQLRDLEA---KV 1551
Query: 543 ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ 602
+ EL G+++ Q++ E+E+ R + R+EE+ R Q Q
Sbjct: 1552 KDQEEELDEQAGTIQMLEQAKLRLE---MEMERMRQTHSKEMESRDEEVEEAR---QSCQ 1605
Query: 603 LKLASTEESMCQLAKDQRKML 623
KL E + + +D++K+L
Sbjct: 1606 KKLKQMEVQLEEEYEDKQKVL 1626
Score = 52.8 bits (125), Expect = 2e-06
Identities = 54/235 (22%), Positives = 107/235 (45%), Gaps = 20/235 (8%)
Query: 383 EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442
+I+ K LE + QR +++ + E + D+ E + A A++++L+
Sbjct: 1722 DIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQA 1781
Query: 443 QREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQA 502
Q E+ K ++ L E K QA L+ + L Q+ D + V++Q + R+
Sbjct: 1782 QLEEANKEKQELQE---KLQA-------LQSQVEFLEQSMVD----KSLVSRQEAKIREL 1827
Query: 503 QVDLEREK---KELEDSLERISDQGQRKTQEQLEVLESLKQELATS---QRELQVLQGSL 556
+ LE E+ K LE R+ + ++ T+E+ + + + +E + QR+L+ + +
Sbjct: 1828 ETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEM 1887
Query: 557 ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEES 611
A+ EA + + ELE + +SL + + +L K + D Q + ES
Sbjct: 1888 GELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMES 1942
Score = 49.3 bits (116), Expect = 2e-05
Identities = 135/695 (19%), Positives = 253/695 (36%), Gaps = 124/695 (17%)
Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
E +R + +E+++ R EKA++ +E+ + E R S+L SEL R
Sbjct: 1254 EQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELT---SELTDE-----RNTG 1305
Query: 491 EVTKQVSMARQAQ-VDLEREKKELEDSLERISDQGQRKTQEQLEVLES------------ 537
E Q+ A A+ + E+E KEL+ + + Q + ++EV+E+
Sbjct: 1306 ESASQLLDAETAERLRAEKEMKELQTQYDALKKQME---VMEMEVMEARLIRAAEINGEV 1362
Query: 538 ----------LKQELA------TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLV 581
LK E A T +R Q + LE Q++ +L+ + +
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQ 1422
Query: 582 SGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM---LLVGSRKAAEQVIQDA 638
+++ L ELQDT+L L + +L K QR+ L +A + +Q
Sbjct: 1423 RALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQRE 1482
Query: 639 LNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698
Q E+ D LL+ S+ +E+ + + + + L I+
Sbjct: 1483 KLQREK----------DMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532
Query: 699 TSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADST------- 751
++A + D E +Q G + A L E +E T
Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMES 1592
Query: 752 -------AMRNCLSKIKAIGEEL------------LPRGLDIKQEELGDLVD-------- 784
A ++C K+K + +L R L+ K L D V+
Sbjct: 1593 RDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEK 1652
Query: 785 ---KEMAATSAAIETATARIEEML----SKSRAGDTGVKLEVNERILGCCTSLMQAIQVL 837
K++ T A + A ++ + SK +LE +E C + ++A + +
Sbjct: 1653 RLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESE---FTCAAAVKARKAM 1709
Query: 838 IVASKDLQREIVESGRGTASPKEFYAKNSR---------------WTEGLISASKAVGWG 882
V +DL +I + + + +E ++ R E + AV
Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1769
Query: 883 ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGV 942
+ + DL Q +E ++ A +Q+ + DK +L Q+A +
Sbjct: 1770 SRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDK---SLVSRQEAK--I 1824
Query: 943 NQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLE----LENELQKER 998
+ + K + + LT+ + Q + ++ R E L+ +L+ +
Sbjct: 1825 RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1884
Query: 999 QKLGELRKKHYELAGVAEGWE---EGTEASPPTLQ 1030
+++GEL +K E + E E EA+ +LQ
Sbjct: 1885 EEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 75.1 bits (183), Expect = 3e-13
Identities = 140/651 (21%), Positives = 262/651 (40%), Gaps = 86/651 (13%)
Query: 373 KDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEF 432
KD+ + L ++++ L++QL+ ++ E + +LK +E+ + + +Q +QQ A E
Sbjct: 529 KDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEA 588
Query: 433 ---LRAELDELR--RQREDTEKAQRSLSEIERKAQANEQRYSKLKEK---YSELVQNHAD 484
L+ E+ ++ + + L + Q E ++ +KEK ++L AD
Sbjct: 589 RVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEAD 648
Query: 485 LLRKNAEVTKQVSMARQAQVDLEREKKELE---DSLERISDQGQRKTQEQLEV------- 534
+L + A + + DL+R +E E + L+R++D Q+ +V
Sbjct: 649 MLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQR 708
Query: 535 ---LESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEEL 591
LE+L+QE ++L + Q +L++ QS + EL+ L AA RE+ +
Sbjct: 709 DQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI 768
Query: 592 SALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAE--QVIQDALNQLEEPPLIS 649
L+ E E+ Q AK ++ L G+R+ E + + L +L E I
Sbjct: 769 CLLQNE--------KIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIK 820
Query: 650 CAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATT 709
+G +HL ++ +Q++K Q+L + T L S+
Sbjct: 821 -SGQVEHLQQETAALK---KQMQKIKEQFLQQKVMVEAYRRDATSKDQLISE-------- 868
Query: 710 CLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLP 769
L+A + DS + +Q + + E E S + + +R ++ ++ +
Sbjct: 869 -LKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQK 927
Query: 770 RGLDIKQEELGDLVDKE-MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCT 828
+++ DKE M A + A E +IEE+ ++R T K ++ R LG
Sbjct: 928 ERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKM--RRLG--- 982
Query: 829 SLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTE--GLISASKAVGWGATVM 886
DL T++ KE K+ + G++S A
Sbjct: 983 -------------SDL----------TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEA 1019
Query: 887 VDAADLVVQGRGKFEELMVCSHE-IAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQA 945
DA ++ +G + + HE I A A+L A S K + + S+ + +
Sbjct: 1020 ADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEE- 1078
Query: 946 TAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQK 996
S + +E D + S +IKR E ++ LELE+E K
Sbjct: 1079 ---------SREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGK 1120
Score = 47.4 bits (111), Expect = 7e-05
Identities = 140/630 (22%), Positives = 233/630 (36%), Gaps = 88/630 (13%)
Query: 296 PNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSF 355
P+ + S S V+ + SPD++ LE L S+ + D+ + S+
Sbjct: 266 PDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSDSSS-YSSAS 324
Query: 356 SSDPFNFNSQNGVNKDEK-----DHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVS 410
+ + S+ +D + + +K L+ E Q ++ G V
Sbjct: 325 TRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVR 384
Query: 411 E----------LEADLAEQQHLRQQAADDCEFLRAELDELRRQREDT--EKA--QRSLSE 456
LE+ AE Q Q + L +L+ L + EKA Q L+
Sbjct: 385 SRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAA 444
Query: 457 IERKAQA-------NEQRYSKLKEKYSELVQNHADLLR-----KNAEVTKQVSMARQAQV 504
+ K QA ++QR L + L Q+ DL R +N K S+A +
Sbjct: 445 LSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLA-SSNN 503
Query: 505 DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEA 564
DL+ +++ + + ++ D QR + + L+Q++ Q +LQ +Q T
Sbjct: 504 DLQVAEEQYQRLMAKVEDM-QRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLK 562
Query: 565 NWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ------------LKLASTEESM 612
AE + L+ R A +E L+ E+ Q LKL + S
Sbjct: 563 ASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQ 622
Query: 613 CQLAKDQRKMLLVGSRKAAE---------------QVIQDALNQLEEP---PLISCAGSA 654
QL + Q + + R AA+ IQ+A +EE L G
Sbjct: 623 -QLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGER 681
Query: 655 DHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHS-ITLLAHLTSDAIAHGATTCLRA 713
+ L S +S +QLE+ L + + L + L+ LT A L++
Sbjct: 682 ERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEA------LQS 735
Query: 714 PPEPADSL----TEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLP 769
+ D+L E + G E AS E+ L + + L K+ G+E L
Sbjct: 736 REQSLDALQTHYDELQARLG-ELQGEAASREDTICLLQNEKIILEAALQAAKS-GKEELD 793
Query: 770 RG---LDIKQEELGDLVDK---EMAATSAAIE---TATARIEEMLSKSRAGDTGVKLEVN 820
RG L+ EE + ++K E+A S +E TA +++ + K + K+ V
Sbjct: 794 RGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMV- 852
Query: 821 ERILGCCTSLMQAIQVLIVASKDLQREIVE 850
E TS Q I L K L E+ E
Sbjct: 853 EAYRRDATSKDQLISELKATRKRLDSELKE 882
Score = 47.0 bits (110), Expect = 9e-05
Identities = 63/284 (22%), Positives = 126/284 (44%), Gaps = 38/284 (13%)
Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQL---KGHVSEL-EADLAEQ 419
SQ EK +E +E G + +++ ++ ++++ L+L KG ++ L +++ A +
Sbjct: 1073 SQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALR 1132
Query: 420 QH-------LRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLK 472
+H L ++ AD + L ++ + +++E+ ++ + L QA + K K
Sbjct: 1133 EHNSILETALAKREADLVQ-LNLQVQAVLQRKEEEDRQMKHL------VQALQASLEKEK 1185
Query: 473 EKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELE------DSLERISDQGQR 526
EK + L + A E + A ++L KKEL+ L+ +D Q
Sbjct: 1186 EKVNSLKEQVA---AAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI 1242
Query: 527 KTQEQLEVLESLKQELATSQRELQVLQGSLE-------TSAQSEANWAAEFAELEKERDS 579
+ + + + + ELA ++ +LQ+LQ L+ Q N E + E+E S
Sbjct: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302
Query: 580 LVSGAAHREE----ELSALRKELQDTQLKLASTEESMCQLAKDQ 619
L E+ EL L++ LQ+ + +L +E + KD+
Sbjct: 1303 LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDK 1346
Score = 45.1 bits (105), Expect = 4e-04
Identities = 56/273 (20%), Positives = 118/273 (43%), Gaps = 36/273 (13%)
Query: 380 LYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439
L+ I L+A+L+ + + +L+ ++ +L E + + D+ + R +
Sbjct: 1040 LHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKK 1099
Query: 440 LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS----ELVQNHADLLRKNAEVTKQ 495
++R E +K L + K Q + L+E S L + ADL++ N +V Q
Sbjct: 1100 IKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQV--Q 1157
Query: 496 VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555
+ R+ + D R+ K L +L Q +++ E + SLK+++A ++ E
Sbjct: 1158 AVLQRKEEED--RQMKHLVQAL-------QASLEKEKEKVNSLKEQVAAAKVE------- 1201
Query: 556 LETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQL 615
+ + ++ A EL + + L + +E + L+ E D Q++ + + Q
Sbjct: 1202 ---AGHNRRHFKAASLELSEVKKELQA----KEHLVQKLQAEADDLQIREGKHSQEIAQF 1254
Query: 616 AKDQRKMLLVGSRKAAEQVIQDALN-QLEEPPL 647
+ + +A Q++Q L+ QL + P+
Sbjct: 1255 QAE------LAEARAQLQLLQKQLDEQLSKQPV 1281
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 73.9 bits (180), Expect = 7e-13
Identities = 126/672 (18%), Positives = 259/672 (38%), Gaps = 96/672 (14%)
Query: 369 NKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAAD 428
N ++ +E +E++ L+ +K ES+ +L V EL A ++E LR + A+
Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280
Query: 429 DCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRK 488
L+ ELD + E+ EK + + A + E + +E E + +L +
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKG---IKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337
Query: 489 NAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ---GQRKTQEQLEVLESLKQELATS 545
++ ++ + ++ Q + E +K LE + + Q ++K + L +ESL++
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397
Query: 546 QRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKL 605
++ + L LE A + L++E D L H+ + S L K+
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK-------- 1449
Query: 606 ASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSIS 665
++ QL +++ + +R A E+ +A + +E +S A + + L
Sbjct: 1450 ---QKKFDQLLAEEKS---ISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFE 1503
Query: 666 SCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEAC 725
+QL ++ +D+ +H + + A
Sbjct: 1504 RQNKQLRADMEDLMSSKDDVGKNVHEL--------------------------EKSKRAL 1537
Query: 726 KQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDK 785
+Q E L LE+E + + +KA E L + D + EE L+ K
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL-QTRDEQNEEKKRLLIK 1596
Query: 786 EMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN--------ERILGCCTSLMQAIQVL 837
++ A +E +E ++ A + K+E++ E +++ ++ L
Sbjct: 1597 QVRELEAELE------DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL 1650
Query: 838 IVASKDLQREIVESGRGTASPKEFYAKNS--------------RWTEGLISASKAVGWGA 883
KD QRE+ E+ AS E +A++ + E L S+ +A
Sbjct: 1651 QAQMKDYQRELEEA---RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE 1707
Query: 884 TVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVN 943
+ AD + L+ + A AQL + + +++ N+ L R
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQL----EEELEEEQSNMELLNDRFRKTT 1763
Query: 944 QATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKE------ 997
+ A + +S +++DN Q++RQ + + ++ ELE ++ +
Sbjct: 1764 LQVDTLNAELAAERSAAQKSDN------ARQQLERQNKELKAKLQELEGAVKSKFKATIS 1817
Query: 998 --RQKLGELRKK 1007
K+G+L ++
Sbjct: 1818 ALEAKIGQLEEQ 1829
Score = 63.5 bits (153), Expect = 1e-09
Identities = 133/679 (19%), Positives = 269/679 (39%), Gaps = 95/679 (13%)
Query: 384 ISGLKAQL---ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDEL 440
IS L+ +L E + E ++ +L G ++L+ +AE L+A++DEL
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE--------------LQAQIDEL 1081
Query: 441 RRQ-REDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMA 499
+ Q + E+ Q +L+ + + ++E +++ + D + A K
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141
Query: 500 RQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETS 559
R +LE K ELED+L+ + Q + +T+ + EV E LK+ L + E + + ++
Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE-LKKAL---EEETKNHEAQIQDM 1197
Query: 560 AQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQ 619
Q A E +E ++ + ++ L KEL + E + Q K +
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL--------ACEVKVLQQVKAE 1249
Query: 620 RKMLLVGSRKAAEQVIQDALNQLEEPP--LISCAGSADHLLSTVTSISSCIEQLEKSWSQ 677
+ RK + +Q+ ++ E + A A L + + ++S+ +E+ EK +
Sbjct: 1250 SE----HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 678 YLACPEDI-SGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSL-------TEACKQYG 729
+ + S L + LL T + ++ +R E +SL EA K
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKL--NLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363
Query: 730 RETLAYLASL--------EEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGD 781
++ LA + L ++ G++E+ + A + L +A+ + L
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEE-AKKKLLKDAEALSQRL-------------- 1408
Query: 782 LVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVAS 841
+E A +E R+++ L D V L+ ++ + L+
Sbjct: 1409 ---EEKALAYDKLEKTKNRLQQELD-----DLTVDLDHQRQVASNLEKKQKKFDQLLAEE 1460
Query: 842 KDLQ-REIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF 900
K + R E R A +E K +S ++A+ + Q R
Sbjct: 1461 KSISARYAEERDRAEAEAREKETK-------ALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 901 EELMVCSHEIAASTAQLVAASKV---KADKDSPNLAQLQQASRGVNQATAGVVASTISGK 957
E+LM ++ + +L + + + ++ L +L+ + A + + + K
Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573
Query: 958 SQIE-ETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAE 1016
+Q E + D + + K++ + QVR LE E E +++++ L KK E+ +
Sbjct: 1574 AQFERDLQTRDEQN----EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID--LK 1627
Query: 1017 GWEEGTEASPPTLQEVVTE 1035
E EA+ EV+ +
Sbjct: 1628 DLEAQIEAANKARDEVIKQ 1646
Score = 62.4 bits (150), Expect = 2e-09
Identities = 92/443 (20%), Positives = 177/443 (39%), Gaps = 32/443 (7%)
Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDC 430
D+ + RL +E+ L L++ + +V L+ + + LAE++ + + A++
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQR----QVASNLEKKQKKFDQLLAEEKSISARYAEER 1471
Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
+ AE RE KA +E +A E+ + + +L + DL+
Sbjct: 1472 DRAEAEA------REKETKALSLARALEEALEAKEE----FERQNKQLRADMEDLMSSKD 1521
Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQ 550
+V K V +++ LE++ +E+ LE + D+ Q +L + +++ A +R+LQ
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581
Query: 551 VLQGSLETSAQSEANWAAEF-AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609
E + E AELE ER A +++ + +L+D + ++ +
Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK----MEIDLKDLEAQIEAAN 1637
Query: 610 ESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIE 669
++ ++ K RK L K ++ +++A +E S L S I E
Sbjct: 1638 KARDEVIKQLRK--LQAQMKDYQRELEEARASRDEI-FAQSKESEKKLKSLEAEILQLQE 1694
Query: 670 QLEKSWSQYLACPEDISGLLHSITLLAHLTSDAI-----AHGATTCLRAPPEPADSLTEA 724
+L S ++ L IT A S + L E S E
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754
Query: 725 CKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD 784
R+T + +L E + E + + N +++ +EL K +EL V
Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL-----KAKLQELEGAVK 1809
Query: 785 KEMAATSAAIETATARIEEMLSK 807
+ AT +A+E ++EE L +
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQ 1832
Score = 57.0 bits (136), Expect = 9e-08
Identities = 112/576 (19%), Positives = 224/576 (38%), Gaps = 69/576 (11%)
Query: 439 ELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSM 498
++ RQ E+ + L +++ K E +++ K+ +L++ L + T+ +
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 499 ARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATS----QRELQVLQG 554
A + + L +K+ELE+ L + + + + +E+ ++L++ K+++ + +L +G
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEE-EERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 555 SLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614
+ + + A+ ++E+E L + +E + + + +LA EE
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 615 LAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKS 674
LAK + K ++ S ++ Q E G L + + + I++L+
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK-- 1082
Query: 675 WSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLA 734
Q E++ G A+A G L A K RE A
Sbjct: 1083 -LQLAKKEEELQG--------------ALARGDDETLHK--------NNALKVV-RELQA 1118
Query: 735 YLASLEEEGSLENADSTAMRNCLSKIKA-IGEELLPRGLDIKQEELGDLVDKEMAATSAA 793
+A L+E+ E A RN K K + EE L+ + EL D +D T+A
Sbjct: 1119 QIAELQEDFESEKAS----RNKAEKQKRDLSEE-----LEALKTELEDTLD----TTAAQ 1165
Query: 794 IETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGR 853
E T R +E+ +A + E + Q A ++L ++ ++
Sbjct: 1166 QELRTKREQEVAELKKA--------LEEETKNHEAQIQDMRQRHATALEELSEQLEQA-- 1215
Query: 854 GTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAAS 913
K F A + +GL + +K + V+ R K + + H +
Sbjct: 1216 -----KRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSE 1270
Query: 914 TAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTL 973
+L KA K L + + S +SQ+++T + L
Sbjct: 1271 GDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL------L 1324
Query: 974 TQIKRQEMDSQVRVLELE---NELQKERQKLGELRK 1006
+ RQ+++ R+ +LE N LQ+++++ E RK
Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360
Score = 57.0 bits (136), Expect = 9e-08
Identities = 143/756 (18%), Positives = 311/756 (41%), Gaps = 99/756 (13%)
Query: 331 DLMDMDASQQNLFDNKFDDIFGSSFSSDPFNF------NSQNGVNKDEKDHLIERLYREI 384
+L +M+ Q L + K +I ++ F ++ K E + ++ L +
Sbjct: 874 ELEEMERKHQQLLEEK--NILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV 931
Query: 385 SGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQR 444
+ + + ++ E ++ ++ H+ +LE L E++ RQ+ E + AE ++++
Sbjct: 932 EEEEERNQILQNEKKK----MQAHIQDLEEQLDEEEGARQKL--QLEKVTAEA-KIKKME 984
Query: 445 EDTEKAQRSLSEIERKAQANEQRYSKLKEKYS---ELVQNHADLLRKN----AEVTKQVS 497
E+ + S+ ++ + E R ++ + + E +N A + K +++ +++
Sbjct: 985 EEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK 1044
Query: 498 MARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQ--VLQGS 555
+ + +LE+ K++L+ + DQ E ++ LK +LA + ELQ + +G
Sbjct: 1045 KEEKTRQELEKAKRKLDGETTDLQDQ----IAELQAQIDELKLQLAKKEEELQGALARGD 1100
Query: 556 LETSAQSEA-----NWAAEFAELEKERDSLVSGAAHRE-------EELSALRKELQDTQL 603
ET ++ A A+ AEL+++ +S + E EEL AL+ EL+DT
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160
Query: 604 KLASTEESMCQLAKD--QRKMLLVGSRKAAEQVIQD-------ALNQLEEPPLISCAGSA 654
A+ +E + ++ + K L K E IQD AL +L E + A
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKA 1220
Query: 655 D-----HLLSTVTSISSC---IEQLEKSWSQYLACPEDIS-GLLHSITLLAHLTSDAIAH 705
+ L T +C + Q K+ S++ D LH+ +A
Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280
Query: 706 GATTCLRAPPEPADSLTEACK---QYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKA 762
A+ + L EA K ++ ++ + + L++ L ++ N S+I+
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340
Query: 763 IGEELLPRGLDIKQEELGDL---VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV 819
+ EE L +QEE + ++K++ A + + ++++ L + + E
Sbjct: 1341 LEEE--KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE-----EA 1393
Query: 820 NERILGCCTSLMQAIQVLIVA-------SKDLQREI------VESGRGTASPKEFYAKNS 866
+++L +L Q ++ +A LQ+E+ ++ R AS E K
Sbjct: 1394 KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE---KKQ 1450
Query: 867 RWTEGLISASKAVGWGATVMVDAADLVVQGR--------GKFEELMVCSHEIAASTAQLV 918
+ + L++ K++ D A+ + + EE + E QL
Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510
Query: 919 A-ASKVKADKD--SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQ 975
A + + KD N+ +L+++ R + Q + + +++ T++ Q
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 976 IKRQEMDSQVRVLELENELQKERQKLGELRKKHYEL 1011
+ + + ++ + +NE +K+R + ++R+ EL
Sbjct: 1571 AMKAQFERDLQTRDEQNE-EKKRLLIKQVRELEAEL 1605
Score = 46.2 bits (108), Expect = 2e-04
Identities = 55/279 (19%), Positives = 118/279 (42%), Gaps = 41/279 (14%)
Query: 370 KDEKDHLIERLYREISGLKAQLENMKT----------ESQRVVLQLKGHVSELEADLAEQ 419
+DE + +L ++ + +LE + ES++ + L+ + +L+ +LA
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699
Query: 420 QHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELV 479
+ R+ A E DEL + ++ + +L + +R+ +A R ++L+E+ E
Sbjct: 1700 ERARRHAEQ-------ERDELADEITNSASGKSALLDEKRRLEA---RIAQLEEELEEEQ 1749
Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE-SL 538
N L + + T QV A++ ER + D+ + ++ ++ + +L+ LE ++
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLN-AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808
Query: 539 KQELATSQRELQVLQGSLETSAQSEANWAAE---------------FAELEKERDSLVSG 583
K + + L+ G LE + EA A F ++E ER
Sbjct: 1809 KSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER----RH 1864
Query: 584 AAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM 622
A +E++ ++ + +L EE + +RK+
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903
Score = 39.3 bits (90), Expect = 0.019
Identities = 50/209 (23%), Positives = 93/209 (44%), Gaps = 31/209 (14%)
Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
+ D+ ++L R+ LKA+L+ ++ V + K +S LEA + + + +Q A +
Sbjct: 1782 KSDNARQQLERQNKELKAKLQELEGA---VKSKFKATISALEAKIGQLEEQLEQEAKE-- 1836
Query: 432 FLRAELDELRRQREDTEKAQRSLSEI-----------ERKAQANEQRYSKLKEKYSELVQ 480
RA ++L R+ E + L EI ++ + E+ +++K+ +L +
Sbjct: 1837 --RAAANKLVRRTE------KKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE 1888
Query: 481 NHADLLRKNA---EVTKQVSMARQAQVDLEREKKELEDSLER---ISDQGQRKTQEQLEV 534
+ R NA ++ +++ A +A L RE L++ L R IS R + QL
Sbjct: 1889 AEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLH- 1947
Query: 535 LESLKQELATSQRELQVLQGSLETSAQSE 563
LE EL+ E + + QSE
Sbjct: 1948 LEGASLELSDDDTESKTSDVNETQPPQSE 1976
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 73.6 bits (179), Expect = 9e-13
Identities = 125/705 (17%), Positives = 260/705 (36%), Gaps = 82/705 (11%)
Query: 328 EKDDLMDMDASQQNLFDNKFDD--IFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREIS 385
E +D +D A+QQ L + + I + + +Q + + +E L ++
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 386 G---LKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442
+KA LE K + +L V L + +H R++ + L+ + +E R
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 443 QRED----TEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSM 498
R + K Q L + ++ + SKL + +S L D E +Q
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326
Query: 499 ARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLET 558
+E EK + LE ++ + ++Q+ L + ++A +++++ G LET
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEE-EEEAKHNLEKQIATLHA---QVADMKKKMEDSVGCLET 1382
Query: 559 SAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKD 618
+ + + + L + + V+ E+ + L++EL D + L +S C L K
Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442
Query: 619 QRKM-------LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQL 671
Q+K + ++ A E+ +A + +E +S A + + + + +Q
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQF 1502
Query: 672 EKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRE 731
++ +D+ +H + + A +Q E
Sbjct: 1503 RTEMEDLMSSKDDVGKSVHEL--------------------------EKSKRALEQQVEE 1536
Query: 732 TLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATS 791
L LE+E + L +KA E L +G D + EE + +++
Sbjct: 1537 MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDL-QGRDEQSEEKKKQLVRQVREME 1595
Query: 792 AAIETATARIEEMLSKSRAGDTGVKLEVNERILGC--------CTSLMQAIQVLIVASKD 843
A +E +E +S A KLE++ + L ++ ++ L KD
Sbjct: 1596 AELE------DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 844 LQRE-----------IVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADL 892
RE + ++ K A+ + E L +A +A + AD
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709
Query: 893 VVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVAS 952
+ GK + + A AQL + + +++ N + + N +
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQL----EEELEEEQGNTELINDRLKKANLQIDQINTD 1765
Query: 953 TISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKE 997
+S ++ +N Q++RQ + +V++ E+E ++ +
Sbjct: 1766 LNLERSHAQKNEN------ARQQLERQNKELKVKLQEMEGTVKSK 1804
Score = 70.5 bits (171), Expect = 8e-12
Identities = 132/669 (19%), Positives = 265/669 (39%), Gaps = 81/669 (12%)
Query: 366 NGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425
N ++EK + +L + + LE ++ +L+ +LE D + L Q
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD---LSDQ 1063
Query: 426 AADDCEFLRAELDELRRQ-REDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD 484
A+ L+A++ EL+ Q + E+ Q +L+ +E +A K++E S++ + D
Sbjct: 1064 IAE----LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119
Query: 485 LLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELAT 544
L + A K R +LE K ELED+L+ + Q + +++
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR-------------- 1165
Query: 545 SQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
++E+ +L+ +LE A++ A+ E+ ++ V A + E+ ++ L+ +
Sbjct: 1166 -EQEVNILKKTLEEEAKTH---EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221
Query: 605 LASTEESMCQLAKDQRKMLLVG------SRKAAEQVIQDALNQLEEPPLISCAGSADHLL 658
L E +LA ++ K+LL G RK E +Q+ + E + AD +
Sbjct: 1222 L---ENERGELA-NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR-TELADKVT 1276
Query: 659 STVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPA 718
+ + L +S S+ +D S L ++ L+
Sbjct: 1277 KLQVELDNVTGLLSQSDSKSSKLTKDFSAL------------ESQLQDTQELLQEENRQK 1324
Query: 719 DSLTEACKQYGRETLAYLASLEEE----GSLENADSTAMRNCLSKIKAIGEEL--LPRGL 772
SL+ KQ E ++ LEEE +LE +T K + + + L
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Query: 773 DIKQEELGDLV-----DKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCC 827
++K++ DL +E A +E R+++ L D V L+ +
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD-----DLLVDLDHQRQSACNL 1439
Query: 828 TSLMQAIQVLIVASKDLQREIVES-GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVM 886
+ L+ K + + E R A +E K +S ++A+
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETK-------ALSLARALEEAMEQK 1492
Query: 887 VDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKV---KADKDSPNLAQLQQASRGVN 943
+ L Q R + E+LM ++ S +L + + + ++ L +L+ +
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552
Query: 944 QATAGVVASTISGKSQIE-ETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLG 1002
A + + + K+Q E + D S + K++++ QVR +E E E +++++ +
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQS----EEKKKQLVRQVREMEAELEDERKQRSMA 1608
Query: 1003 ELRKKHYEL 1011
+K E+
Sbjct: 1609 VAARKKLEM 1617
Score = 60.8 bits (146), Expect = 6e-09
Identities = 115/501 (22%), Positives = 210/501 (41%), Gaps = 89/501 (17%)
Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVV--LQLKGHVS-ELEADLA--EQQHLRQQ 425
+E++ L ++I+ L AQ+ +MK + + V L+ V +L+ DL Q+H +
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV 1405
Query: 426 AADDCEFLRAELDELRRQRE------DTEKAQRSLSEIERKAQANEQRYSKLKE---KYS 476
AA D + E + R Q+E D + ++S +E+K + +Q ++ K KY+
Sbjct: 1406 AAYD----KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYA 1461
Query: 477 ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE 536
E ++ A+ + E TK +S+AR + +E++ + LER++ Q + ++E L
Sbjct: 1462 E-ERDRAEAEAREKE-TKALSLARALEEAMEQKAE-----LERLNKQ----FRTEMEDLM 1510
Query: 537 SLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRK 596
S K ++ S EL+ + +LE Q + ELE E + E L A++
Sbjct: 1511 SSKDDVGKSVHELEKSKRALE---QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567
Query: 597 ELQ-DTQLKLASTEESMCQLAKDQRKM------------LLVGSRKAAEQVIQDALNQLE 643
+ + D Q + +EE QL + R+M + V +RK E ++D
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDL----- 1622
Query: 644 EPPLISCAGSADHLLSTVTSISS----CIEQLEK---SWSQYLACPEDISGLLHSITLLA 696
E + S + D + + + + C+ +L+ S + LA ++ L S+
Sbjct: 1623 EAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM 1682
Query: 697 HLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAY---------LASLEEEGSLEN 747
+ +A +A E + E G+ LA +A LEEE E
Sbjct: 1683 IQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ 1742
Query: 748 ADSTAMRNCLSK----IKAIGEEL-LPRG------------------LDIKQEELGDLVD 784
++ + + L K I I +L L R L +K +E+ V
Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK 1802
Query: 785 KEMAATSAAIETATARIEEML 805
+ A+ A+E A++EE L
Sbjct: 1803 SKYKASITALEAKIAQLEEQL 1823
Score = 58.2 bits (139), Expect = 4e-08
Identities = 138/646 (21%), Positives = 253/646 (39%), Gaps = 98/646 (15%)
Query: 392 ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTEKA 450
EN TE + + QL +AE+ L++Q + E L AE +ELR R ++
Sbjct: 865 ENRLTEMETLQSQL----------MAEKLQLQEQLQAETE-LCAEAEELRARLTAKKQEL 913
Query: 451 QRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREK 510
+ ++E + + E+R L+ + ++ QN E+ +Q+ A+ L+ EK
Sbjct: 914 EEICHDLEARVEEEEERCQHLQAEKKKMQQN-------IQELEEQLEEEESARQKLQLEK 966
Query: 511 KELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF 570
E L +K +E+ +LE +LA ++ L+ T+ E +
Sbjct: 967 VTTEAKL--------KKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL 1018
Query: 571 AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMC-QLAKDQRKMLLVGSRK 629
A+L+ + +++++ R R+EL+ T+ KL + Q+A+ Q ++ + +
Sbjct: 1019 AKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078
Query: 630 A-AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC------- 681
A E+ +Q AL ++EE A + L + + S I +L++ A
Sbjct: 1079 AKKEEELQAALARVEEE-----AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
D+ L ++ T D+ A A LR+ E +E +LEE
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTA--AQQELRSKRE-------------QEVNILKKTLEE 1178
Query: 742 EGSLENADSTAMRNCLSK-IKAIGEEL---------LPRGLDIKQEELGDLVD--KEMAA 789
E A MR S+ ++ + E+L L + + E G+L + K +
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238
Query: 790 TSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIV 849
E ++E L + + VK ER+ T L + L V ++ +
Sbjct: 1239 GKGDSEHKRKKVEAQLQELQ-----VKFNEGERVR---TELADKVTKLQVELDNVTGLLS 1290
Query: 850 ES-GRGTASPKEFYAKNSRW--TEGLISASKAVGWG-ATVMVDAADLVVQGRGKFEELMV 905
+S + + K+F A S+ T+ L+ +T + D R + EE
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE 1350
Query: 906 CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
H + A L VA K K + L ++ R + + + G SQ E
Sbjct: 1351 AKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQK--------DLEGLSQRHE 1402
Query: 963 TDNMDFSSMTLTQIK-RQEMDSQVRVLELENELQKERQKLGELRKK 1007
+ + T+ + +QE+D +L +L +RQ L KK
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELD------DLLVDLDHQRQSACNLEKK 1442
Score = 55.8 bits (133), Expect = 2e-07
Identities = 122/593 (20%), Positives = 239/593 (40%), Gaps = 96/593 (16%)
Query: 439 ELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSM 498
++ RQ E+ + L ++ K A E R ++++ S+L+ L + T+ +
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 499 ARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLET 558
A + + L +K+ELE+ I + + +E+ E + L+ E Q+ +Q L+ LE
Sbjct: 899 AEELRARLTAKKQELEE----ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE- 953
Query: 559 SAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKD 618
E A + +LEK A K+L++ Q+ L E+ C+LAK+
Sbjct: 954 ----EEESARQKLQLEK-------------VTTEAKLKKLEEEQIIL---EDQNCKLAKE 993
Query: 619 QRKMLLVGSRKAAEQVIQDALNQL--EEPPLISCAGSADHLLSTVTSISSCIEQLEKSWS 676
+K E I + L EE S A + + +T + + + EK
Sbjct: 994 ---------KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQ 1044
Query: 677 QYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYL 736
+ + G + SD IA L+A + A+ + K+ E A L
Sbjct: 1045 ELEKTRRKLEGDSTDL-------SDQIAE-----LQA--QIAELKMQLAKK-EEELQAAL 1089
Query: 737 ASLEEEGSLENADSTAMRNCLSKIKAIGEEL-LPRGLDIKQEELGDLVDKEMAATSAAIE 795
A +EEE + +N +R S+I + E+L R K E+ + +E+ A +E
Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE 1149
Query: 796 ---TATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESG 852
+TA +E+ SK +K + E + + Q A ++L ++ ++
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209
Query: 853 RGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG-----------KFE 901
R A+ L A + + + + +++QG+G + +
Sbjct: 1210 RVKAN--------------LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255
Query: 902 ELMVCSHE---IAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958
EL V +E + A V +V+ D + L+Q S + + + + +S
Sbjct: 1256 ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL-------ES 1308
Query: 959 QIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYEL 1011
Q+++T + L + RQ++ ++ ++E+E R++L E + + L
Sbjct: 1309 QLQDTQEL------LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 72.8 bits (177), Expect = 2e-12
Identities = 103/510 (20%), Positives = 215/510 (42%), Gaps = 71/510 (13%)
Query: 369 NKDEKDHLIERLYREISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLRQQ 425
+K + D +++ E+SGL++++E+ + + Q+ + +L+ + ELE ++ ++ R +
Sbjct: 1076 DKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAK 1135
Query: 426 AADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485
A L EL+E+ + E+ A + E+ +K +A Q+ + E+ + + A
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1195
Query: 486 LRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRKTQEQLEV 534
LRK AE+ +Q+ ++ + LE+EK E++ ++ ++ + + ++
Sbjct: 1196 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRA 1255
Query: 535 LESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHREEE 590
LE E+ T + E Q L L + E++ E+D+LVS G ++
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315
Query: 591 LSALRKELQD---TQLKLASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQVIQ- 636
+ L+++L++ + LA +S C L ++Q + L KA +V Q
Sbjct: 1316 IEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQW 1375
Query: 637 ------DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLH 690
DA+ + EE + L + +E + + + + +
Sbjct: 1376 RTKYETDAIQRTEE-----LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVE 1430
Query: 691 SITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEG------- 743
+ + T+ A A L D + KQ ET A L + ++E
Sbjct: 1431 DLMIDVERTNAACA-----ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485
Query: 744 -SLENADSTAM----------RNCLSKIKAIGEELLPRGLDIKQ-EELGDLVDKEMAATS 791
++NA ++ +N +I + E++ G I + E++ V++E +
Sbjct: 1486 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ 1545
Query: 792 AAIETATARIEEMLSKSRAGDTGVKLEVNE 821
AA+E A A +E K ++LE+N+
Sbjct: 1546 AALEEAEASLEHEEGKI----LRIQLELNQ 1571
Score = 57.4 bits (137), Expect = 7e-08
Identities = 87/425 (20%), Positives = 185/425 (43%), Gaps = 45/425 (10%)
Query: 390 QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEK 449
QL K + + + ++ + E AE +++ D+C L+ ++D+L
Sbjct: 911 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL--------- 961
Query: 450 AQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLERE 509
+ +L+++E++ A E + L E+ + L + A L ++ K + A Q +D +
Sbjct: 962 -ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK----KALQEAHQQTLD---D 1013
Query: 510 KKELEDSLERISDQGQRKTQEQLEVLE-SLKQELATS---QRELQVLQGSLETSAQSEAN 565
+ ED + ++ + + K ++Q++ LE SL+QE +R + L+G L+ + +S +
Sbjct: 1014 LQAEEDKVNTLT-KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMD 1072
Query: 566 WAAEFAELE---KERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM 622
+ +L+ K+++ +SG + E+ AL +LQ +L + E + + + +R
Sbjct: 1073 IENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAER-- 1130
Query: 623 LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
SR AE+ D +LEE ++ L + S+ IE +K +++
Sbjct: 1131 ---ASRAKAEKQRSDLSRELEE--------ISERLEEAGGATSAQIEMNKKREAEFQKMR 1179
Query: 683 EDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEE 742
D L TL T+ + + E D+L ++ +E +++
Sbjct: 1180 RD----LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1235
Query: 743 GSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIE 802
S S A N +A+ ++L + K+EE L++ ++ A A ++T +
Sbjct: 1236 ASNMETVSKAKGNLEKMCRALEDQL--SEIKTKEEEQQRLIN-DLTAQRARLQTESGEYS 1292
Query: 803 EMLSK 807
L +
Sbjct: 1293 RQLDE 1297
Score = 55.5 bits (132), Expect = 3e-07
Identities = 146/671 (21%), Positives = 260/671 (38%), Gaps = 70/671 (10%)
Query: 387 LKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRED 446
+ A+L K + + +LK + +LE LA+ + + + + L E+ L
Sbjct: 936 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 995
Query: 447 TEKAQRSLSEIERKA----QANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQA 502
K +++L E ++ QA E + + L + +L Q D L + E K++ M
Sbjct: 996 LTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ-QVDDLEGSLEQEKKIRM---- 1050
Query: 503 QVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETS--- 559
DLER K++LE L+ Q T + + L ++L + E+ LQ +E
Sbjct: 1051 --DLERAKRKLEGDLK----LAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQAL 1104
Query: 560 ----AQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQL 615
+ A ELE+E ++ + A E++ S L +EL++ +L E
Sbjct: 1105 GMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL----EEAGGA 1160
Query: 616 AKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSW 675
Q +M K E Q LEE L A +A S++ EQ++
Sbjct: 1161 TSAQIEM-----NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1215
Query: 676 SQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAY 735
++ S + I D +A T +A +L + C+ + L+
Sbjct: 1216 RVKQKLEKEKSEMKMEI--------DDLASNMETVSKA----KGNLEKMCRAL-EDQLSE 1262
Query: 736 LASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIE 795
+ + EEE D TA R L GE R LD K + L + A T IE
Sbjct: 1263 IKTKEEEQQRLINDLTAQRARLQ--TESGE--YSRQLDEKDTLVSQLSRGKQAFTQ-QIE 1317
Query: 796 TATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGT 855
++EE + A ++ ++ C L + + A +LQR + ++
Sbjct: 1318 ELKRQLEEEIKAKSALAHALQSSRHD-----CDLLREQYEEEQEAKAELQRAMSKANSEV 1372
Query: 856 ASPKEFYAKNS-RWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAAST 914
A + Y ++ + TE L A K + A + DA + V K L +
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKL---AQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429
Query: 915 AQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFS-SMTL 973
L+ + ++ + A L + R ++ A +++E + S S L
Sbjct: 1430 EDLM----IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485
Query: 974 TQIKR--QEMDSQVRVLELENE-LQKE----RQKLGELRKKHYELAGVAEGWEEGTEASP 1026
+IK +E Q+ L+ EN+ LQ+E +++ E K+ +EL + + E+
Sbjct: 1486 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ 1545
Query: 1027 PTLQEVVTEKE 1037
L+E E
Sbjct: 1546 AALEEAEASLE 1556
Score = 52.4 bits (124), Expect = 2e-06
Identities = 121/603 (20%), Positives = 227/603 (37%), Gaps = 66/603 (10%)
Query: 460 KAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLER 519
K+ E+ + +KE++ + + A K E+ +++ Q + DL+ + + DSL
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 520 ISDQGQR--KTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKER 577
++ + KT+ QLE E A + E+ + + + E +EL+K+
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC------SELKKDI 958
Query: 578 DSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637
D L A E+E A ++++ ++A +E++ +L K+++ + ++A +Q + D
Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDD 1013
Query: 638 ALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAH 697
Q EE + + + L V + +EQ +K + G + L
Sbjct: 1014 L--QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG---DLKLAQE 1068
Query: 698 LTSD------------AIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745
T D + L++ E +L ++ +E A + LEEE
Sbjct: 1069 STMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEA 1128
Query: 746 ENADSTAMRNCLSKIKAIGEELLPR-----GLDIKQEELGDLVDKEMAATSAAIETATAR 800
E A S + EE+ R G Q E+ + E +E AT +
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 801 IEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKE 860
E + R E+ E+I +L + Q L +++ EI + AS E
Sbjct: 1189 HEATAATLRKKHADSVAELGEQI----DNLQRVKQKLEKEKSEMKMEIDD----LASNME 1240
Query: 861 FYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAA 920
+ SKA G + D + + + K EE +++ A A+L
Sbjct: 1241 -------------TVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTE 1287
Query: 921 SKVKADKDSPNLAQLQQASRGVNQATAGV------VASTISGKSQIEETDNMDFSSMTLT 974
S + + + Q SRG T + + I KS + + S
Sbjct: 1288 SGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHA--LQSSRHDCD 1345
Query: 975 QIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVT 1034
++ Q + Q EL+ + K ++ + R K YE + + EE EA Q +
Sbjct: 1346 LLREQYEEEQEAKAELQRAMSKANSEVAQWRTK-YETDAI-QRTEELEEAKKKLAQRLQD 1403
Query: 1035 EKE 1037
+E
Sbjct: 1404 AEE 1406
Score = 50.4 bits (119), Expect = 8e-06
Identities = 120/666 (18%), Positives = 258/666 (38%), Gaps = 92/666 (13%)
Query: 417 AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSL----SEIERKAQANEQRYSKLK 472
AE + ++ E + EL + +R++ E+ +L ++++ + QA + +
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAE 906
Query: 473 EKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL 532
E+ +L++ L K EVT++ + +L +K++LED +
Sbjct: 907 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD--------- 957
Query: 533 EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELS 592
++ L+ LA ++E + ++ + A A+L KE+ +L ++L
Sbjct: 958 --IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015
Query: 593 A------------LRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN 640
A ++ E Q L+ + +E ++ ++ K L G K A++ D N
Sbjct: 1016 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEN 1075
Query: 641 ---QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAH 697
QL+E L L S + + QL+K + A E++ + A
Sbjct: 1076 DKQQLDE-KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIE-----AE 1129
Query: 698 LTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLE-------------EEGS 744
S A A + L + ++E ++ G T A + + EE +
Sbjct: 1130 RASRAKAEKQRSDL---SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1186
Query: 745 L--ENADSTAMRNCLSKIKAIGEEL-----LPRGLDIKQEELGDLVDKEMAATSAAIETA 797
L E +T + + +GE++ + + L+ ++ E+ +D ++A+ + A
Sbjct: 1187 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-DLASNMETVSKA 1245
Query: 798 TARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES---- 851
+E+M + + + K E +R++ T+ +Q S + R++ E
Sbjct: 1246 KGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQ---TESGEYSRQLDEKDTLV 1302
Query: 852 ---GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSH 908
RG + + + R E I A A+ DL+ R ++EE
Sbjct: 1303 SQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLL---REQYEEEQEAKA 1359
Query: 909 EIAASTAQL---VAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEETD 964
E+ + ++ VA + K + D+ +L++A + +A + + E
Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQDAEEHVEAV 1411
Query: 965 NMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEA 1024
N +S+ T +Q + ++V +L ++++ L KK + W++ E
Sbjct: 1412 NAKCASLEKT---KQRLQNEVE--DLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEE 1466
Query: 1025 SPPTLQ 1030
+ L+
Sbjct: 1467 THAELE 1472
Score = 48.1 bits (113), Expect = 4e-05
Identities = 76/363 (20%), Positives = 154/363 (42%), Gaps = 52/363 (14%)
Query: 370 KDEKDHLIERLY---REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426
++ K L +RL + + A+ +++ QR+ +++ + ++E A L ++
Sbjct: 1391 EEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQ 1450
Query: 427 ADDCEFL---RAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELV 479
+ + L + + +E + E ++K RSLS +I+ + + + LK + L
Sbjct: 1451 RNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQ 1510
Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE--------------------- 518
Q +DL + AE K++ + + +E+EK EL+ +LE
Sbjct: 1511 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELN 1570
Query: 519 RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFA 571
++ + RK E+ E ++ +K+ R ++ +Q +L+ +S + +
Sbjct: 1571 QVKSEVDRKIAEKDEEIDQMKR---NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1627
Query: 572 ELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLAKDQRKMLLVGS 627
E+E + + AA + L+DTQL L S E+ QLA +R+ L+ +
Sbjct: 1628 EMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQA 1687
Query: 628 -----RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
R EQ + ++ E L+ + L + TS+ + ++LE SQ
Sbjct: 1688 EIEELRATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEM 1745
Query: 683 EDI 685
EDI
Sbjct: 1746 EDI 1748
Score = 42.0 bits (97), Expect = 0.003
Identities = 43/236 (18%), Positives = 104/236 (44%), Gaps = 12/236 (5%)
Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
+E+ +++ + T++ ++ K +++ E + + Q+A + E + + +
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAA 1767
Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
E+ +K Q + + +ER + EQ L+ + E Q L ++ K + R+
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ--LALKGGKKQIQKLEARVRE 1825
Query: 502 AQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSL----- 556
+ ++E E+K ++++ + + +RK +E E ++ + Q + LQ +
Sbjct: 1826 LEGEVESEQKRNVEAVKGLR-KHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKR 1884
Query: 557 ---ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609
E QS N ++F ++ E + A E +++ LR + ++ K+ S E
Sbjct: 1885 QAEEAEEQSNVN-LSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 72.4 bits (176), Expect = 2e-12
Identities = 114/518 (22%), Positives = 216/518 (41%), Gaps = 86/518 (16%)
Query: 370 KDEKDHLIERLYR---EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLR 423
+++K L E+L + E+S L+ ++E+ + + Q+ + +L+ + ELE ++ ++ R
Sbjct: 1074 ENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASR 1133
Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
+A L EL+E+ + E+ A + E+ +K +A Q+ + E+ + + A
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATA 1193
Query: 484 DLLRKN-----AEVTKQVSMARQAQVDLEREKKELE-------DSLERISDQGQRKTQEQ 531
LRK AE+ +Q+ ++ + LE+EK EL+ ++E +S + + ++
Sbjct: 1194 AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVS-KAKANFEKM 1252
Query: 532 LEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHR 587
LE E+ T + E Q L L + EF+ E+D++VS G
Sbjct: 1253 CRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAF 1312
Query: 588 EEELSALRKEL-QDTQLK--LASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQV 634
+++ L+++L ++T+ K LA +S C L ++Q + L G KA +V
Sbjct: 1313 TQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEV 1372
Query: 635 IQ-------DALNQLE--EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685
Q DA+ + E E A V +++S LEK+ + ED+
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDL 1432
Query: 686 SGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745
+ ++ A L D + KQ ET A L + ++E
Sbjct: 1433 ------------MIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKE--- 1477
Query: 746 ENADSTAMRNCLSKIKAIGEELLPRGLDIK------QEELGDL----------------V 783
S ++ L K+K EE L +K Q+E+ DL V
Sbjct: 1478 ----SRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKV 1533
Query: 784 DKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNE 821
K++ + ++T+ E L ++LE+N+
Sbjct: 1534 KKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQ 1571
Score = 63.2 bits (152), Expect = 1e-09
Identities = 60/296 (20%), Positives = 135/296 (45%), Gaps = 30/296 (10%)
Query: 379 RLYREISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRA 435
+L +++ L+ LE K + +R +L+G + + + ++ +QQ + +
Sbjct: 1030 KLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEF 1089
Query: 436 ELDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAE 491
E+ L+ + ED + + Q+ + E++ + + E+ + ++ + +DL R+ E
Sbjct: 1090 EMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 492 VTK-----------QVSMARQAQVDLEREKKELEDS----------LERISDQGQRKTQE 530
+++ Q+ M ++ + + ++ +++LE+S L + + E
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209
Query: 531 QLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEE 590
Q++ L+ +KQ+L + EL++ L ++ ++ + A F ++ + + +S +EEE
Sbjct: 1210 QIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEE 1269
Query: 591 LSALRKEL--QDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
L EL Q +L S E S KD L ++A Q I++ QLEE
Sbjct: 1270 QQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEE 1325
Score = 62.4 bits (150), Expect = 2e-09
Identities = 75/312 (24%), Positives = 144/312 (46%), Gaps = 44/312 (14%)
Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQH----LRQQ 425
K + DH L + +A LE+ + + R+ L+L SE++ +AE+ L++
Sbjct: 1534 KKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRN 1593
Query: 426 AADDCEFLRAELDELRRQREDT----EKAQRSLSEIERKAQ-ANEQRYSKLKEKYSEL-- 478
E +++ LD R R D +K + L+E+E + AN Q L+ +
Sbjct: 1594 HLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGI 1653
Query: 479 ---VQNHAD-LLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL-- 532
Q H D +R ++ +Q++M + ++ E +EL SLER +++G++ +++L
Sbjct: 1654 LKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLER-TERGRKMAEQELLD 1712
Query: 533 -----EVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFA------------ 571
++L + L ++++L+ +QG +E Q EA A E A
Sbjct: 1713 ASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQ-EARNAEEKAKKAITDAAMMAE 1771
Query: 572 ELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAA 631
EL+KE+D+ +AH E + + ++D QL+L E+ + K Q + L R+
Sbjct: 1772 ELKKEQDT----SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1827
Query: 632 EQVIQDALNQLE 643
+V + + +E
Sbjct: 1828 SEVESEQKHNVE 1839
Score = 57.0 bits (136), Expect = 9e-08
Identities = 117/563 (20%), Positives = 210/563 (37%), Gaps = 66/563 (11%)
Query: 460 KAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLER 519
K+ E+ + +KE++ + + A K E+ +++ Q + DL+ + + D+L
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 520 ISDQGQR--KTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKER 577
++ + KT+ QLE E A + E+ + + + E +EL+K+
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC------SELKKDI 958
Query: 578 DSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637
D L A E+E A ++++ ++A +E++ +L K+++ + ++A +Q + D
Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDD 1013
Query: 638 ALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAH 697
Q+EE + + + L V + +EQ +K + G + L
Sbjct: 1014 L--QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEG---DLKLAQE 1068
Query: 698 LTSDA------------IAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745
T D + L+ E +L ++ +E A + LEEE
Sbjct: 1069 STMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEA 1128
Query: 746 ENADSTAMRNCLSKIKAIGEELLPR-----GLDIKQEELGDLVDKEMAATSAAIETATAR 800
E A S + EE+ R G Q E+ + E +E +T +
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQ 1188
Query: 801 IEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREI--VESGRGTAS- 857
E + R E+ E+I SL + Q L +L+ EI + S T S
Sbjct: 1189 HEATAAALRKKHADSVAELGEQI----DSLQRVKQKLEKEKSELKMEINDLASNMETVSK 1244
Query: 858 PKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQL 917
K + K R E +S K K EE +E++A A+L
Sbjct: 1245 AKANFEKMCRTLEDQLSEIKT--------------------KEEEQQRLINELSAQKARL 1284
Query: 918 VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIK 977
S + + A + Q SRG T + K Q+EE + Q
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEEL----KRQLEEETKAKSTLAHALQSA 1340
Query: 978 RQEMDSQVRVLELENELQKERQK 1000
R + D E E E + E Q+
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQR 1363
Score = 57.0 bits (136), Expect = 9e-08
Identities = 89/428 (20%), Positives = 179/428 (41%), Gaps = 45/428 (10%)
Query: 390 QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEK 449
QL K + + + ++ + E AE +++ D+C L+ ++D+L
Sbjct: 911 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL--------- 961
Query: 450 AQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLERE 509
+ +L+++E++ A E + L E+ + L + A L ++ K + A Q +D
Sbjct: 962 -ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK----KALQEAHQQTLD---- 1012
Query: 510 KKELEDSLERISDQGQRKTQEQLEVLE-SLKQE---LATSQRELQVLQGSLETSAQS--- 562
++E+ + + K ++Q++ LE SL+QE +R + L+G L+ + +S
Sbjct: 1013 DLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMD 1072
Query: 563 EANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM 622
N + E K+++ +S + E+ AL +LQ +L + E + + + +R
Sbjct: 1073 TENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAER-- 1130
Query: 623 LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
SR AE+ D +LEE ++ L + S+ IE +K +++
Sbjct: 1131 ---ASRAKAEKQRSDLSRELEE--------ISERLEEAGGATSAQIEMNKKREAEFQKMR 1179
Query: 683 EDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEE 742
D L TL T+ A+ + E DSL ++ +E + +
Sbjct: 1180 RD----LEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDL 1235
Query: 743 GSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIE 802
S S A N + + ++L + K+EE L++ E++A A + T +
Sbjct: 1236 ASNMETVSKAKANFEKMCRTLEDQL--SEIKTKEEEQQRLIN-ELSAQKARLHTESGEFS 1292
Query: 803 EMLSKSRA 810
L + A
Sbjct: 1293 RQLDEKDA 1300
Score = 52.4 bits (124), Expect = 2e-06
Identities = 65/289 (22%), Positives = 129/289 (44%), Gaps = 55/289 (19%)
Query: 387 LKAQLENMKTESQRVVLQLKGHVSELEADLA---EQQHLRQQAADDCEFLRAELDE---- 439
+ A+L K + + +LK + +LE LA +++H + + A LDE
Sbjct: 936 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 995
Query: 440 LRRQREDTEKA-QRSLSEI---ERKAQANEQRYSKLKEKYSELVQN-------HADLLRK 488
L ++++ ++A Q++L ++ E K + +KL+++ +L + DL R
Sbjct: 996 LTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA 1055
Query: 489 NAEVTKQVSMARQAQVDLEREKKELEDSLER-----------------ISDQGQRKTQEQ 531
++ + +A+++ +D E +K++L + L++ ++ Q Q+K +E
Sbjct: 1056 KRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKEL 1115
Query: 532 LEVLESLKQELATSQ--------------RELQVLQGSLE-----TSAQSEANWAAEFAE 572
+E L++E+ + REL+ + LE TSAQ E N E AE
Sbjct: 1116 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE-AE 1174
Query: 573 LEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRK 621
+K R L E +ALRK+ D+ +L +S+ ++ + K
Sbjct: 1175 FQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEK 1223
Score = 48.5 bits (114), Expect = 3e-05
Identities = 74/358 (20%), Positives = 154/358 (43%), Gaps = 53/358 (14%)
Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
+D ++H +E + + + L+ + ++ E + +++ ++ + A +Q++ + A+
Sbjct: 1402 QDAEEH-VEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAE- 1459
Query: 430 CEFLRAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELVQNHADL 485
+ + +E + + E ++K RSLS +++ + + LK + L Q +DL
Sbjct: 1460 ---WKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDL 1516
Query: 486 LRKNAEVTKQVSMARQAQVDLEREKKELEDSLE---------------------RISDQG 524
+ AE K + + + L+ EK EL+ SLE ++ +
Sbjct: 1517 TEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Query: 525 QRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFAELEKER 577
RK E+ E L+ LK+ R ++ +Q +L+ +S + + E+E +
Sbjct: 1577 DRKIAEKDEELDQLKR---NHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQL 1633
Query: 578 DSLVSGAAHREEELSALRKELQDTQLKL----ASTEESMCQLAKDQRKMLLVGSRKAAEQ 633
+ AA L + L+DTQL L ++ QLA +R+ L+ +A +
Sbjct: 1634 NHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLM---QAEVE 1690
Query: 634 VIQDALNQLE------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685
++ +L + E E L+ + L + TS+ + ++LE SQ EDI
Sbjct: 1691 ELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748
Score = 47.8 bits (112), Expect = 5e-05
Identities = 46/244 (18%), Positives = 102/244 (41%), Gaps = 27/244 (11%)
Query: 417 AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSL----SEIERKAQANEQRYSKLK 472
AE + ++ E + EL + +R++ E+ +L ++++ + QA + +
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAE 906
Query: 473 EKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL 532
E+ +L++ L K EVT++ + +L +K++LED +
Sbjct: 907 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD--------- 957
Query: 533 EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSL-------VSGAA 585
++ L+ LA ++E + ++ + A A+L KE+ +L +
Sbjct: 958 --IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015
Query: 586 HREEELSALRKELQDTQLKLASTEESMCQLAK-----DQRKMLLVGSRKAAEQVIQDALN 640
E++++ L K + ++ E S+ Q K ++ K L G K A++ D N
Sbjct: 1016 MEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEN 1075
Query: 641 QLEE 644
++
Sbjct: 1076 DKQQ 1079
Score = 41.2 bits (95), Expect = 0.005
Identities = 88/501 (17%), Positives = 194/501 (38%), Gaps = 44/501 (8%)
Query: 559 SAQSEANWAAEFAELEKERDSLVSGAAHR---EEELSALRKELQDTQLKLASTEESMCQL 615
SA++E A E EK ++ L A R EE++ L +E D QL++ + +++
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADA 905
Query: 616 AKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSW 675
++R L+ ++ E I++ + E+ I+ +A +LE
Sbjct: 906 --EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK------------RKLEDEC 951
Query: 676 SQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTE---ACKQYGRET 732
S+ +D+ L + H T + + + T + E LT+ A ++ ++T
Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKN-LTEEMAGLDETIAKLTKEKKALQEAHQQT 1010
Query: 733 LAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSA 792
L L E++ + T + + ++ E+ +D+++ + D ++A S
Sbjct: 1011 LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQEST 1070
Query: 793 A-IETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES 851
E ++ E L K + ++ ++ + L + I+ L ++L+ EI
Sbjct: 1071 MDTENDKQQLNEKLKKKEFEMSNLQGKIEDE-QALAIQLQKKIKELQARIEELEEEIEAE 1129
Query: 852 GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIA 911
A ++ + SR E + + G + ++ + + E ++
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE------MNKKREAEFQKMRRDLE 1183
Query: 912 ASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE-TDNMDFSS 970
ST Q A + K + ++A+L + + + + K +I + NM+ S
Sbjct: 1184 ESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVS 1243
Query: 971 MT--------------LTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAE 1016
L++IK +E + Q + EL + + + GE ++ E +
Sbjct: 1244 KAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVS 1303
Query: 1017 GWEEGTEASPPTLQEVVTEKE 1037
G +A ++E+ + E
Sbjct: 1304 QLSRGKQAFTQQIEELKRQLE 1324
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 72.0 bits (175), Expect = 3e-12
Identities = 132/695 (18%), Positives = 292/695 (42%), Gaps = 73/695 (10%)
Query: 379 RLYREISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRA 435
RL +++ L+ LE ++ +++R +L+G + + +A+ +QQ + + +
Sbjct: 1075 RLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDS 1134
Query: 436 ELDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAE 491
EL +L + ED + + Q+ + E++ +A+ E+ + + + + A+ R+ E
Sbjct: 1135 ELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEE 1194
Query: 492 VTKQVSMA-----------RQAQVDLEREKKELED----------SLERISDQGQRKTQE 530
+++++ A R+ + +L R ++ELE+ +L R +G + E
Sbjct: 1195 LSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGE 1254
Query: 531 QLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEE 590
Q++ L+ ++Q+L + EL++ L + ++ A +L + + +S A + EE
Sbjct: 1255 QVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE 1314
Query: 591 LSALRKELQDTQLKLASTEESMCQLAKDQRKML--LVGSRKAAEQVIQDALNQLEEPPLI 648
L + + +L + + +L +++ ++ L + A Q +++ QLEE
Sbjct: 1315 LQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEE--- 1371
Query: 649 SCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGAT 708
S A SA L V ++ + L + + ++ LL A+
Sbjct: 1372 SKAKSA--LAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK------------ANAEV 1417
Query: 709 TCLRAPPEPADSL--TEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766
R+ E AD++ TE ++ ++ L EE NA +++ +++ E+
Sbjct: 1418 AQWRSKYE-ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESED 1476
Query: 767 LLPRGLDIKQ-EELGDLVDKEMAATSAAIETATARIEEM---LSKSRAGDTGVKLEVNER 822
+ L++++ +DK+ A+E + EEM L ++ G+ E+ R
Sbjct: 1477 VT---LELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTEL-FR 1532
Query: 823 ILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWG 882
+ ++A++ L +K+LQ EI + + + + + + L KA+ G
Sbjct: 1533 LRHGHEEALEALETLKRENKNLQEEI-------SDLTDQVSLSGKSIQELEKTKKALE-G 1584
Query: 883 ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKV-KADKDSPNLAQLQQASRG 941
+ AA +G + EE ++ S + K+ + D++ NL + Q R
Sbjct: 1585 EKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQ--RA 1642
Query: 942 VNQATAGVVASTISGKSQIEETDNMDFS----SMTLTQIKRQEMDSQVRVLELENELQKE 997
V A + A T + + M+ + L RQ ++Q ++ +L++E
Sbjct: 1643 VESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEE 1702
Query: 998 RQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEV 1032
+ E ++ EL A+ E L+E+
Sbjct: 1703 QAGRDEEQRLAAELHEQAQALERRASLLAAELEEL 1737
Score = 71.2 bits (173), Expect = 5e-12
Identities = 84/328 (25%), Positives = 147/328 (44%), Gaps = 29/328 (8%)
Query: 370 KDEKDHLIERLY-REISGLKAQLE---NMKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425
KDE+ + R + R + L+A L+ + E+ R+ +++G +++LE L H +Q
Sbjct: 1628 KDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLG---HATRQ 1684
Query: 426 AADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSEL--VQNHA 483
A + R +L+ ++ ++ QR +E+ +AQA E+R S L + EL
Sbjct: 1685 ATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQG 1744
Query: 484 DLLRKNAE-----VTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538
+ R+ AE T+++++ L +KK+LE L ++S + + QE+ E E
Sbjct: 1745 ERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKA 1804
Query: 539 KQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR--EEELSALRK 596
K+ + + + L+ +TSA E ++K + V R E E +ALR
Sbjct: 1805 KKAITDAAMMAEELKKEQDTSAHLE--------RMKKTLEQTVRELQARLEEAEQAALRG 1856
Query: 597 ELQDTQLKLASTEESMCQLAKDQRK--MLLVGSRKAAEQVIQDALNQLEE--PPLISCAG 652
+ Q A E +L +Q+K L G RK E+ +++ Q EE L
Sbjct: 1857 GKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRK-HERRVKELAYQAEEDRKNLARMQD 1915
Query: 653 SADHLLSTVTSISSCIEQLEKSWSQYLA 680
D L S V S E+ E+ + LA
Sbjct: 1916 LVDKLQSKVKSYKRQFEEAEQQANTNLA 1943
Score = 67.4 bits (163), Expect = 7e-11
Identities = 140/653 (21%), Positives = 254/653 (38%), Gaps = 100/653 (15%)
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
+E L R+++ Q ++TES EL L E++ L Q +
Sbjct: 1312 VEELQRQLADASTQRGRLQTES-----------GELSRLLEEKECLISQLSRGKALAAQS 1360
Query: 437 LDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR----KNAEV 492
L+ELRRQ E+ KA+ +L+ QA L+E++ E + A+L R NAEV
Sbjct: 1361 LEELRRQLEEESKAKSALA---HAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEV 1417
Query: 493 ----TKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRE 548
+K + A Q +LE KK+L L+ +++G + LE K L T +
Sbjct: 1418 AQWRSKYEADAIQRTEELEEAKKKLALRLQE-AEEGVEAANAKCSSLEKAKLRLQTESED 1476
Query: 549 LQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAST 608
+ L+ TSA A L+K++ L R + +++EL+ Q +
Sbjct: 1477 V-TLELERATSAA---------AALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGL 1526
Query: 609 EESMCQLAKDQRKML-LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSC 667
+ +L + L + + K + +Q+ ++ L + +S +G ++ +
Sbjct: 1527 GTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQ--VSLSG------KSIQELEKT 1578
Query: 668 IEQLEKSWSQYLACPEDISGLL---HSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEA 724
+ LE S+ A E+ G L + TL L + L E +L
Sbjct: 1579 KKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLR-- 1636
Query: 725 CKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD 784
+ + R + ASL+ E T RN L +K++ GDL D
Sbjct: 1637 -RNHQRAVESLQASLDAE--------TRARN--------------EALRLKKKMEGDLND 1673
Query: 785 KEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQ---VLIVAS 841
E+ A + A+ L +++ + + +R+ QA++ L+ A
Sbjct: 1674 LELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAE 1733
Query: 842 KDLQREIVESGRGT--ASPKEFYAKNSR------WTEGLISASKAVGWGATVMVDAADLV 893
+ R +E G + + +E R GL++ K + + +
Sbjct: 1734 LEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEA 1793
Query: 894 VQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVAST 953
Q R + EE A T + A ++K ++D+ A L++ + + Q +
Sbjct: 1794 AQERREAEE-----KAKKAITDAAMMAEELKKEQDTS--AHLERMKKTLEQTVREL---- 1842
Query: 954 ISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRK 1006
++++EE + L K+Q + +V ELE EL E++K E K
Sbjct: 1843 ---QARLEEAE-----QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALK 1887
Score = 65.5 bits (158), Expect = 3e-10
Identities = 146/678 (21%), Positives = 284/678 (41%), Gaps = 114/678 (16%)
Query: 387 LKAQLENMKTESQRVVL------QLKGHVSELEADLAEQQHL-------RQQAADDCEFL 433
L+A+ +N+ +R L QL+G V EL L +++ + R++ D+C L
Sbjct: 940 LQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTEL 999
Query: 434 RAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493
+ ++D+L+ +L++ E++ QA E + L E+ + L ++ A L ++ +
Sbjct: 1000 KKDIDDLK----------LTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ 1049
Query: 494 KQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE-SLKQE---LATSQREL 549
+ +QA DL+ E ED + ++ + + + ++Q+E LE SL+QE ++R
Sbjct: 1050 E---AHQQALGDLQAE----EDRVSALT-KAKLRLEQQVEDLECSLEQEKKLRMDTERAK 1101
Query: 550 QVLQGSLETSAQSEANWAAEFAELE---KERDSLVSGAAHREEELSAL----RKELQDTQ 602
+ L+G L+ + +S A+ A + +LE K++DS +S + R E+ L +K++++ Q
Sbjct: 1102 RKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ 1161
Query: 603 LKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVT 662
+ EE + A+ + + R A + +++ +LEE S AG +
Sbjct: 1162 ARAEELEEEL--EAERAARARVEKQRAEAARELEELSERLEEAGGAS-AGQREGCRKREA 1218
Query: 663 SISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLT 722
+ +LE+ + L H T+ A A GA E DSL
Sbjct: 1219 ELGRLRRELEE------------AALRHEATVAALRRKQ--AEGAAEL----GEQVDSLQ 1260
Query: 723 EACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL 782
++ +E + E +E D A L++ KA E+L D E +
Sbjct: 1261 RVRQKLEKE--------KSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSE--AKI 1310
Query: 783 VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVAS- 841
+E+ A T R++ + +G+ LE E C S + + L S
Sbjct: 1311 KVEELQRQLADASTQRGRLQ-----TESGELSRLLEEKE----CLISQLSRGKALAAQSL 1361
Query: 842 KDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFE 901
++L+R++ E + ++ L A +A+ ++ + + + + + +
Sbjct: 1362 EELRRQLEEESKAKSA--------------LAHAVQALRHDCDLLREQHEEEAEAQAELQ 1407
Query: 902 ELMVCSHEIAASTAQLVAASKVKADKD----SPNLA-QLQQASRGVNQATAGVVASTISG 956
L+ ++ A A ++ ++ LA +LQ+A GV A A S++
Sbjct: 1408 RLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANA--KCSSLEK 1465
Query: 957 KSQIEETDNMDFS-SMTLTQIKRQEMDSQVRVLE--LENELQKERQKLGELRKKHYELAG 1013
+T++ D + + +D + R LE LE ++E + EL E G
Sbjct: 1466 AKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRG 1525
Query: 1014 VA-------EGWEEGTEA 1024
+ G EE EA
Sbjct: 1526 LGTELFRLRHGHEEALEA 1543
Score = 58.2 bits (139), Expect = 4e-08
Identities = 64/280 (22%), Positives = 130/280 (46%), Gaps = 33/280 (11%)
Query: 372 EKDHLIERLYR---EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425
+K L E+L + E+S L ++E+ + + Q+ + +L+ ELE +L ++ R +
Sbjct: 1121 DKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARAR 1180
Query: 426 AADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNH--- 482
EL+EL + E+ A E RK +A +L+ + E H
Sbjct: 1181 VEKQRAEAARELEELSERLEEAGGASAGQREGCRKREA---ELGRLRRELEEAALRHEAT 1237
Query: 483 -ADLLRKN----AEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL---EV 534
A L RK AE+ +QV ++ + LE+EK EL ++ ++ + T+ + ++
Sbjct: 1238 VAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKL 1297
Query: 535 LESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEK---ERDSLVS----GAAHR 587
+ + +L+ ++ +++ LQ L ++ E EL + E++ L+S G A
Sbjct: 1298 CRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALA 1357
Query: 588 EEELSALRKELQD---TQLKLASTEESM---CQLAKDQRK 621
+ L LR++L++ + LA +++ C L ++Q +
Sbjct: 1358 AQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHE 1397
Score = 55.5 bits (132), Expect = 3e-07
Identities = 107/504 (21%), Positives = 209/504 (41%), Gaps = 72/504 (14%)
Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431
E + +E + S L+ ++TES+ V L+L+ S A +Q+HL +
Sbjct: 1448 EAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERA------ 1501
Query: 432 FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN-- 489
L+E RRQ E+ QR L +R+++ +L+ + E ++ L R+N
Sbjct: 1502 -----LEERRRQEEEM---QRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKN 1553
Query: 490 -----AEVTKQVSMARQAQVDLEREKKELEDSLERI-SDQGQRKTQEQLEVLESLKQELA 543
+++T QVS++ ++ +LE+ KK LE I + + + +LE ++L+ +L
Sbjct: 1554 LQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLE 1613
Query: 544 TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRK---ELQD 600
SQ + +V + E + +E + SL + R E L +K +L D
Sbjct: 1614 LSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLND 1673
Query: 601 TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLE---EPPLISCAGSADHL 657
+L+L Q + Q L+ ++ EQ +D +L + A L
Sbjct: 1674 LELQLGHATR---QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLL 1730
Query: 658 LSTVTSISSCIEQLEKS---WSQYLACPEDISGLLHSITL------------LAHLTSDA 702
+ + + + +EQ E+S Q L + LLHS LA L+ +
Sbjct: 1731 AAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGE- 1789
Query: 703 IAHGATTCLRAPPEPADSLTEACK-----QYGRETLAYLASL---------EEEGSLENA 748
+ A A + ++T+A + ++T A+L + E + LE A
Sbjct: 1790 VEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEA 1849
Query: 749 DSTAMRNCLSKIKAIGEEL--LPRGLDIKQEELGDLVD---------KEMAATSAAIETA 797
+ A+R +++ + ++ L LD +Q++ + + KE+A +
Sbjct: 1850 EQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKN 1909
Query: 798 TARIEEMLSKSRAGDTGVKLEVNE 821
AR+++++ K ++ K + E
Sbjct: 1910 LARMQDLVDKLQSKVKSYKRQFEE 1933
Score = 52.4 bits (124), Expect = 2e-06
Identities = 84/381 (22%), Positives = 152/381 (39%), Gaps = 74/381 (19%)
Query: 425 QAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD 484
QA ++ LRAEL LR +L+ E K Q E+ + + ++ ++L
Sbjct: 893 QAEEELAALRAELRGLRG----------ALAAAEAKRQELEETHVSITQEKNDLALQLQA 942
Query: 485 LLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELAT 544
A+ ++ + +++V LE + KEL E+LE E + +LA
Sbjct: 943 EQDNLADAEERCHLLIKSKVQLEGKVKELS---------------ERLEDEEEVNADLAA 987
Query: 545 SQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLK 604
+R+L+ E EL+K+ D L A E+E A ++++ +
Sbjct: 988 RRRKLE-----------------DECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEE 1030
Query: 605 LASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLE-EPPLISCAGSADHLLSTVTS 663
+A+ +ES+ +L K+ +KA ++ Q AL L+ E +S L
Sbjct: 1031 MAALDESVARLTKE---------KKALQEAHQQALGDLQAEEDRVSA------LTKAKLR 1075
Query: 664 ISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTE 723
+ +E LE S Q D + LT +++A A + L E
Sbjct: 1076 LEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAA--------QDKQQLEE 1127
Query: 724 ACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL- 782
K+ E +E+E L M+ + +++A EEL +++ E
Sbjct: 1128 KLKKKDSELSQLSLRVEDEQLL----GAQMQKKIKELQARAEELEE---ELEAERAARAR 1180
Query: 783 VDKEMAATSAAIETATARIEE 803
V+K+ A + +E + R+EE
Sbjct: 1181 VEKQRAEAARELEELSERLEE 1201
Score = 50.1 bits (118), Expect = 1e-05
Identities = 106/490 (21%), Positives = 197/490 (40%), Gaps = 71/490 (14%)
Query: 559 SAQSEANWAAEFAELEKERDSLVSGAAHR---EEELSALRKELQDTQLKLASTEESMCQL 615
SAQ+E AA AEL R +L + A R EE ++ +E D L+L + ++++
Sbjct: 891 SAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLAD- 949
Query: 616 AKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISC--AGSADHLLSTVTSISSCIEQLE- 672
++R LL+ S+ E +++ +LE+ ++ A L T + I+ L+
Sbjct: 950 -AEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008
Query: 673 ---KSWSQYLACPEDISGLLHSITLL----AHLTSDAIA-----HGATTCLRAPPEPADS 720
K+ + A + L + L A LT + A A L+A + +
Sbjct: 1009 TLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSA 1068
Query: 721 LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG 780
LT+A + ++ SLE+E L A R L L + QE +
Sbjct: 1069 LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRK------------LEGDLKLTQESVA 1116
Query: 781 DLV-DKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV-NERILGCCTSLMQAIQVLI 838
D DK+ ++EE L K + + + L V +E++LG + + I+ L
Sbjct: 1117 DAAQDKQ-------------QLEEKLKKKDSELSQLSLRVEDEQLLG--AQMQKKIKELQ 1161
Query: 839 VASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG 898
+++L+ E+ A ++ A+ +R E L + G + + G
Sbjct: 1162 ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELG 1221
Query: 899 KFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958
+ + E A VAA + K + + L + + + V Q KS
Sbjct: 1222 RLRREL---EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLE-------KEKS 1271
Query: 959 QIE-ETDNMDFSSMTLTQIKR-----------QEMDSQVRVLELENELQKERQKLGELRK 1006
++ E D++ + TLT+ K Q +++++V EL+ +L + G L+
Sbjct: 1272 ELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQT 1331
Query: 1007 KHYELAGVAE 1016
+ EL+ + E
Sbjct: 1332 ESGELSRLLE 1341
Score = 32.3 bits (72), Expect = 2.4
Identities = 69/326 (21%), Positives = 125/326 (38%), Gaps = 56/326 (17%)
Query: 737 ASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIET 796
A EEE + A+ +R L+ +A +EL + I QE+ ++A A +
Sbjct: 892 AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEK------NDLALQLQAEQD 945
Query: 797 ATARIEE---MLSKSRAGDTGVKLEVNERI---------LGC--------CTSLMQAIQ- 835
A EE +L KS+ G E++ER+ L CT L + I
Sbjct: 946 NLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDD 1005
Query: 836 -VLIVASKDLQREIVESG-----RGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDA 889
L +A + +++ E+ A+ E A+ ++ + L A + D
Sbjct: 1006 LKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDR 1065
Query: 890 ADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGV 949
+ + + + E+ ++ L K++ D + + ++ G + T
Sbjct: 1066 VSALTKAKLRLEQ------QVEDLECSLEQEKKLRMDTE-----RAKRKLEGDLKLTQES 1114
Query: 950 VASTISGKSQIEET---DNMDFSSMTL---------TQIKRQEMDSQVRVLELENELQKE 997
VA K Q+EE + + S ++L Q++++ + Q R ELE EL+ E
Sbjct: 1115 VADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAE 1174
Query: 998 RQKLGELRKKHYELAGVAEGWEEGTE 1023
R + K+ E A E E E
Sbjct: 1175 RAARARVEKQRAEAARELEELSERLE 1200
Score = 30.4 bits (67), Expect = 9.0
Identities = 24/112 (21%), Positives = 52/112 (46%), Gaps = 14/112 (12%)
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGH---VSELEADLAEQQHLRQQAADDCEFL 433
+++L ++ L+A+L+ + + + ++ H V EL E + + D + L
Sbjct: 1861 VQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKL 1920
Query: 434 RAELDELRRQREDTE-----------KAQRSLSEIERKAQANEQRYSKLKEK 474
++++ +RQ E+ E KAQ L + E +A E + +KL+ +
Sbjct: 1921 QSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRAR 1972
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 71.2 bits (173), Expect = 5e-12
Identities = 153/707 (21%), Positives = 283/707 (40%), Gaps = 102/707 (14%)
Query: 365 QNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQ 424
Q + +++ + RL +E +A L K + ++L+ ++E + A Q
Sbjct: 994 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053
Query: 425 QAADDCEFLRAELDELR----RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSE--- 477
A + E EL +LR Q ++ E+ ++++ +++ + E+ ++ SE
Sbjct: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113
Query: 478 --------LVQNHADLLRKNAEVTKQVSMARQAQVDLEREKK---ELEDSLERISDQGQR 526
L A++ + + KQ A + LE E+ E + +LE + Q +
Sbjct: 1114 RTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE 1173
Query: 527 KTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAH 586
K QE L + LA++QREL + ++ +++E W A+ A +E + S +
Sbjct: 1174 KAQE----LGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISS 1229
Query: 587 REEELS-----ALRKELQDTQLK-LASTEESMCQLAKDQRKMLLV----GSRKAAEQ--V 634
EEE+S L KE + +LK L E Q +++ ++L S +AAE+
Sbjct: 1230 LEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSA 1289
Query: 635 IQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLE---KSWSQYLACPEDISGLLHS 691
+++ + L E S ++L +TS + E+L K+W + E
Sbjct: 1290 LREEVQSLREEAEKQRVAS-ENLRQELTSQAERAEELGQELKAWQEKFFQKEQA------ 1342
Query: 692 ITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADST 751
L++ + H +T L + PA L C+Q E A A LE +
Sbjct: 1343 ------LSTLQLEHTSTQALVSELLPAKHL---CQQLQAEQAA--AEKRHREELEQSKQA 1391
Query: 752 AMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD-----KEMAATSAAIETATARIEEMLS 806
A + ELL Q ELG+L+ E T+ + A E LS
Sbjct: 1392 A--------GGLRAELLR-----AQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLS 1438
Query: 807 KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPK-EFYAKN 865
+ G+ E N + Q ++V + +++ + + + R A + +
Sbjct: 1439 MLKKAH-GLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQRE 1497
Query: 866 SRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASK--- 922
++ T + A GA V V++ R +F+E ++ A QL +
Sbjct: 1498 AQSTARELEVMTAKYEGAKVK------VLEERQRFQEE---RQKLTAQVEQLEVFQREQT 1548
Query: 923 VKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMD 982
+ ++ S LA QAS+ Q V A G+SQ E + Q+ ++E
Sbjct: 1549 KQVEELSKKLADSDQASKVQQQKLKAVQAQ--GGESQQEAQRLQAQLNELQAQLSQKEQA 1606
Query: 983 SQVRVLELE-------------NELQKERQKLGELRKKHYELAGVAE 1016
++ L++E ELQ++ + L +L+K++ EL AE
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAE 1653
Score = 67.8 bits (164), Expect = 5e-11
Identities = 142/686 (20%), Positives = 269/686 (39%), Gaps = 80/686 (11%)
Query: 370 KDEKDHLIERLYRE---ISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426
K+++ L + L ++ GL+ Q+E + + ++ QLK + EA + A
Sbjct: 529 KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588
Query: 427 ADDCEFLRAELDELRRQREDTEKAQRSLSEI-ERKAQANEQRYSKLKEKYSELVQNHADL 485
A++ E E D +Q E EK + + EI +++ Q + + ++ + A+L
Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648
Query: 486 LRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATS 545
RK E+ V ARQ Q + + + ELE L R Q + + + + L+++L
Sbjct: 649 SRKVEELQACVETARQEQHEAQAQVAELELQL-RSEQQKATEKERVAQEKDQLQEQLQAL 707
Query: 546 QRELQVLQGSLETSAQSEANWAAE----FAELEKERDSLVSGAAHREEELSALRKELQDT 601
+ L+V +GSLE + A+ E +EL+ E SLV H+ E RKEL++
Sbjct: 708 KESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE--QHKRE-----RKELEEE 760
Query: 602 QLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLI------------S 649
+ E + QL + + V R+ AE + + E L+ S
Sbjct: 761 RAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS 820
Query: 650 CAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATT 709
A + + + E+ EK+ + E ++G+ L + +A
Sbjct: 821 QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
Query: 710 CLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENAD----STAMRNCLSKIKAIGE 765
RA + + A ++ L++L+E+ + + + T +R + +
Sbjct: 881 LARALQQVQEKEVRA-----QKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASR 935
Query: 766 ELL---PRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNER 822
EL+ R D + E L + ++ +T AA++ E+M G +LE
Sbjct: 936 ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM---------GNELERLRA 986
Query: 823 ILGCCTSLMQAIQVLIVASKDLQREIVESGRGTAS---PKEFYAKNSRWTEGLISASKAV 879
L S Q + +++ R E GR A K A+ + ++ +
Sbjct: 987 AL--MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVE 1044
Query: 880 GWGATVMVDAADLVVQGRGKFEEL---------MVCSHEIAASTAQLVAASKVKADKDSP 930
AT+ A + + GK +EL + E T + + K +K+
Sbjct: 1045 --FATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHA 1102
Query: 931 NLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLEL 990
+ + Q + G + T + + + S++E+ Q ++++ DS R LE
Sbjct: 1103 SGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ----------CQKQQEQADSLERSLEA 1152
Query: 991 ENELQKERQKL-----GELRKKHYEL 1011
E + ER G+L +K EL
Sbjct: 1153 ERASRAERDSALETLQGQLEEKAQEL 1178
Score = 66.2 bits (160), Expect = 1e-10
Identities = 142/705 (20%), Positives = 266/705 (37%), Gaps = 98/705 (13%)
Query: 391 LENMKTESQRVVLQL---KGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDT 447
L+ + + +R+ QL + + ELE +LAE + L + ++ +D L E
Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
Query: 448 EKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLE 507
+ E+E NE +L E + DL + +++ ++++ + DL
Sbjct: 269 AASPLEPKELEELRDKNESLTMRLHETLKQC----QDLKTEKSQMDRKINQLSEENGDLS 324
Query: 508 REKKE-------LEDSLERISDQGQRKTQEQLEVLESLKQELATS-------QRELQVLQ 553
+ +E L+D+L ++++ + TQE LE L++EL+ + + + ++LQ
Sbjct: 325 FKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQ 384
Query: 554 GSL----ETSAQSEANWAAEFAE----------LEKERDSLVSGAAHREEELSALRKELQ 599
G L E +Q + N E E L++E +L + + + L E
Sbjct: 385 GKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERG 444
Query: 600 DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQ--DALNQLEEPPLISCAGSADHL 657
+ KL + E + K Q L+ + + + Q + L Q + L
Sbjct: 445 QQEAKLLA-ERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503
Query: 658 LSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEP 717
S +T++++ I+Q ++ + ++ L S + H + +
Sbjct: 504 TSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQK 563
Query: 718 ADSL------TEACKQYGRETLAYLASLEEEGSLENADSTAMR-NCLSKIKAIGEELLPR 770
L EA +Q + LA A+ E E SL D+ + L K KA E+L +
Sbjct: 564 EQQLKEVAEKQEATRQDHAQQLA-TAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
Query: 771 GLDIKQEELGDL------VDKEMAATSAAIE-----TATARIEEMLSKSRAGDTGVKLE- 818
L + E +E A S +E TAR E+ ++++ + ++L
Sbjct: 623 QLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS 682
Query: 819 ------VNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGL 872
ER+ L + +Q L + K + + E R A E +
Sbjct: 683 EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR-------C 735
Query: 873 ISASKAVGWGATVMVDAADLVVQ---GRGKFEELMVCSHEIAASTAQLVAASKVKADKDS 929
IS KA + LV Q R + EE + A QL A + + +
Sbjct: 736 ISELKA---------ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLR 786
Query: 930 PNLAQLQQASRGVNQATAGVVASTISGKSQIEET--DNMDFSSMTLTQI----------- 976
LA+ A +V + + + E++ + + +M Q+
Sbjct: 787 RELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846
Query: 977 -KRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE 1020
+ QE +V +E +ELQ RQ+ EL + H LA + +E
Sbjct: 847 QELQEAKEKVAGIESHSELQISRQQ-NELAELHANLARALQQVQE 890
Score = 58.5 bits (140), Expect = 3e-08
Identities = 133/559 (23%), Positives = 219/559 (39%), Gaps = 74/559 (13%)
Query: 503 QVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQ-RELQVLQGSLETSAQ 561
Q + R KK+L D +R +++LE+ + ++L T + ++ ++Q ++ A
Sbjct: 213 QFQMRRLKKQLAD---------ERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL 263
Query: 562 SEANWAA---EFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKD 618
AA E ELE+ RD S E L K+ QD + + + + + QL+++
Sbjct: 264 LNEKQAASPLEPKELEELRDKNESLTMRLHETL----KQCQDLKTEKSQMDRKINQLSEE 319
Query: 619 QRKMLLVGSRKAAE-QVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCIE-- 669
+ A+ Q +QDALN+L E + + LS C+E
Sbjct: 320 NGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEK 379
Query: 670 ---------QLEKSWSQYLACPEDISG-LLHSITLLAHLTSDAIAHGAT-TCLRAPPEPA 718
QLE+ SQ P G +L + L L +A A T L+A E
Sbjct: 380 NEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEML 439
Query: 719 DSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEE 778
+ TE +Q + LA EEE ++ T +++ +S + EEL + +
Sbjct: 440 E--TERGQQEAK-LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEEL-----EQASQA 491
Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLI 838
G + ++A+ ++ + T A I++ + G+K + E+ +L Q Q
Sbjct: 492 HGARLTAQVASLTSELTTLNATIQQQDQEL----AGLKQQAKEKQAQLAQTLQQQEQ--- 544
Query: 839 VASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG 898
AS+ L+ + VE + KE K A AT A L
Sbjct: 545 -ASQGLRHQ-VEQLSSSLKQKEQQLKEV-----------AEKQEATRQDHAQQLATAA-- 589
Query: 899 KFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958
EE E A+ QL A K KA K L LQQ + N+A S +
Sbjct: 590 --EEREASLRERDAALKQLEALEKEKAAK----LEILQQQLQVANEARDSAQTSVTQAQR 643
Query: 959 QIEETDNMDFSSMTLTQIKRQEM-DSQVRVLELENELQKERQKLGELRKKHYELAGVAEG 1017
+ E + RQE ++Q +V ELE +L+ E+QK E + E + E
Sbjct: 644 EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ 703
Query: 1018 WEEGTEASPPTLQEVVTEK 1036
+ E+ T + EK
Sbjct: 704 LQALKESLKVTKGSLEEEK 722
Score = 45.4 bits (106), Expect = 3e-04
Identities = 55/275 (20%), Positives = 112/275 (40%), Gaps = 12/275 (4%)
Query: 353 SSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSEL 412
+S++ +G+ +E L ER L+ +L+ + ++ V +L ++
Sbjct: 1431 ASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAR---EKYVQELAAVRADA 1487
Query: 413 EADLAEQQHLRQQAADDCEFLRAE--------LDELRRQREDTEKAQRSLSEIERKAQAN 464
E LAE Q Q A + E + A+ L+E +R +E+ +K + ++E +
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQ 1547
Query: 465 EQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQG 524
++ +L +K ++ Q +K V Q ++Q L+ + EL+ L + +Q
Sbjct: 1548 TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ-KEQA 1606
Query: 525 QRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGA 584
+ Q+E ++ +ELQ SLE + AE L E
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKT 1666
Query: 585 AHREEELSALRKELQDTQLKLASTEESMCQLAKDQ 619
E+ L +++ + ++A ++ + L K Q
Sbjct: 1667 KEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQ 1701
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 71.2 bits (173), Expect = 5e-12
Identities = 109/507 (21%), Positives = 217/507 (42%), Gaps = 64/507 (12%)
Query: 370 KDEKDHLIERLYR---EISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLR 423
++EK L E+L + EIS L++++E+ + + Q+ + +L+ + ELE ++ ++ R
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135
Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
+A L EL+E+ + E+ A + E+ +K +A Q+ + E+ + + A
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195
Query: 484 DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRKTQEQL 532
LRK AE+ +Q+ ++ + LE+EK E++ ++ ++ + + ++
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255
Query: 533 EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHRE 588
LE EL + + E Q L L + EF+ E+++LVS G
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315
Query: 589 EELSALRKELQD---TQLKLASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQVI 635
+++ L+++L++ + LA +S C L ++Q + L KA +V
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375
Query: 636 Q-------DALNQLEE-----PPLISCAGSADHLLSTV----TSISSCIEQLEKSWSQYL 679
Q DA+ + EE L +A+ + V S+ ++L+ +
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435
Query: 680 ACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETL----AY 735
E + ++ +A C E S EA + G E AY
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEA-RSLGTELFKIKNAY 1494
Query: 736 LASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQ-EELGDLVDKEMAATSAAI 794
SL++ +L+ + +N +I + E++ G I + E++ V++E AA+
Sbjct: 1495 EESLDQLETLKREN----KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550
Query: 795 ETATARIEEMLSKSRAGDTGVKLEVNE 821
E A A +E K ++LE+N+
Sbjct: 1551 EEAEASLEHEEGKI----LRIQLELNQ 1573
Score = 63.9 bits (154), Expect = 7e-10
Identities = 98/462 (21%), Positives = 191/462 (41%), Gaps = 77/462 (16%)
Query: 240 VKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFL 299
+KL FK+ L + + E+F K+KD +S + + L E L
Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 300 RASALSEHISPV-----------VVIPAEASSPDSEPVLEKDDLMDMDASQQNLFD---- 344
+ A +E ++ + + A+ E++ ++ A ++ L D
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 345 --NKFDDIFGSSFSSDPFNFNSQNGV-NKDEK----DHLIERLYREISGL----KAQLEN 393
DD+ + + ++N V N E+ D I +L +E L + L++
Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015
Query: 394 MKTESQRV------VLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRE-D 446
++ E +V ++L+ V +LE L +++ LR +L+ +R+ E D
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-----------DLERAKRKLEGD 1064
Query: 447 TEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD--------------LLRKNAEV 492
+ AQ S+ +IE + Q +++ K + + S L D L + E+
Sbjct: 1065 LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL 1124
Query: 493 TKQVSMARQAQVDLEREKKELEDSLERISDQGQR---KTQEQLEVLESLKQELATSQREL 549
+++ R ++ E+++ +L LE IS++ + T Q+E+ + + E +R+L
Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1184
Query: 550 QVLQGSLE---TSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD------ 600
+ + +L+ T+A A AEL ++ D+L E+E S ++ E+ D
Sbjct: 1185 E--EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242
Query: 601 TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQL 642
T K E MC+ +DQ L K+ E+ Q +N L
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSEL-----KSKEEEQQRLINDL 1279
Score = 60.1 bits (144), Expect = 1e-08
Identities = 95/516 (18%), Positives = 218/516 (42%), Gaps = 77/516 (14%)
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
+E+ ++ G Q + ++ + +R +L+G + + + + ++ +QQ + + E
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE 1092
Query: 437 LDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492
+ L+ + ED + + Q+ + E++ + + E+ + ++ + +DL R+ E+
Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152
Query: 493 TK-----------QVSMARQAQVDLEREKKELED----------SLERISDQGQRKTQEQ 531
++ Q+ M ++ + + ++ +++LE+ +L + + EQ
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212
Query: 532 LEVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587
++ L+ +KQ+L + E+++ L ++ET ++++ N LE + L S +
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS----K 1268
Query: 588 EEELSALRKEL--QDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEP 645
EEE L +L Q +L+ S E S K+ L ++A Q I++ QLEE
Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328
Query: 646 PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705
I + H L + + + QY E + L +++ + +A
Sbjct: 1329 --IKAKNALAHALQSSRHDCDLLRE------QYEEEQESKAELQRALS----KANTEVAQ 1376
Query: 706 GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGE 765
T + + L EA K+ + L + EE NA ++ +++ E
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQR----LQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432
Query: 766 ELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLS--KSRAGDTGVKLEVNE-- 821
+L+ LD+++ A AA++ +++L+ K + +T +LE ++
Sbjct: 1433 DLM---LDVERTN----------AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE 1479
Query: 822 ---------RILGCCTSLMQAIQVLIVASKDLQREI 848
+I + ++ L +K+LQ+EI
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEI 1515
Score = 59.3 bits (142), Expect = 2e-08
Identities = 136/675 (20%), Positives = 268/675 (39%), Gaps = 69/675 (10%)
Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHL-------RQ 424
EK+ L ++ E GL A E + + +QL+ + E+ +++ + ++
Sbjct: 889 EKNDLQLQVQAEAEGL-ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKR 947
Query: 425 QAADDCEFLRAELDELRRQREDTEK----AQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480
+ D+C L+ ++D+L EK + + + + ++ +KL ++ L +
Sbjct: 948 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007
Query: 481 NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRK------- 527
H L +V+ +A++ LE++ +LE SLE+ ++ +RK
Sbjct: 1008 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067
Query: 528 TQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587
QE + +E+ KQ+L ++ + +L++ + E A +L+K+ L +
Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE---QALGIQLQKKIKELQARIEEL 1124
Query: 588 EEELSALR-------KELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN 640
EEE+ A R K+ D +L E + + + + ++ AE Q
Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE--FQKMRR 1182
Query: 641 QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS 700
LEE L A +A S++ EQ++ ++ S + I
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI-------- 1234
Query: 701 DAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKI 760
D +A T +A +L + C+ + L+ L S EEE D TA R L
Sbjct: 1235 DDLASNVETVSKA----KGNLEKMCRTL-EDQLSELKSKEEEQQRLINDLTAQRGRLQ-- 1287
Query: 761 KAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN 820
GE R LD K+ + L + A T IE ++EE + A ++ +
Sbjct: 1288 TESGE--FSRQLDEKEALVSQLSRGKQAFTQ-QIEELKRQLEEEIKAKNALAHALQSSRH 1344
Query: 821 ERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNS-RWTEGLISASKAV 879
+ C L + + + +LQR + ++ A + Y ++ + TE L A K +
Sbjct: 1345 D-----CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399
Query: 880 G---WGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQ-L 935
A V+A + K ++ + E + A+ DK N + L
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459
Query: 936 QQASRGVNQATAGVVASTISGKS---QIEETDNMDFSSM-TLTQIKRQEMDSQVRVLELE 991
+ + + A + AS +S ++ + N S+ L +KR+ + Q + +L
Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1519
Query: 992 NELQKERQKLGELRK 1006
++ + +++ EL K
Sbjct: 1520 EQIAEGGKRIHELEK 1534
Score = 55.5 bits (132), Expect = 3e-07
Identities = 68/284 (23%), Positives = 129/284 (45%), Gaps = 42/284 (14%)
Query: 388 KAQLENMKTESQRVVLQLKGHVSELEADLAEQQH----LRQQAADDCEFLRAELDELRRQ 443
+A LE+ + + R+ L+L SE++ +AE+ L++ E +++ LD R
Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS 1613
Query: 444 REDT----EKAQRSLSEIE-------RKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492
R D +K + L+E+E R A + Y + + + D LR ++
Sbjct: 1614 RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673
Query: 493 TKQVSMARQAQVDLEREKKELEDSLE------RISDQGQRKTQEQLEVLESLKQELATSQ 546
+Q++M + L+ E +EL +LE +I++Q E++++L + L ++
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1733
Query: 547 RELQV----LQGSLETSAQSEANWAAEFA------------ELEKERDSLVSGAAHREEE 590
++L+ +QG +E Q EA A E A EL+KE+D+ +AH E
Sbjct: 1734 KKLETDISQMQGEMEDILQ-EARNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERM 1788
Query: 591 LSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQV 634
+ + ++D QL+L E+ + K Q + L R+ +V
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1832
Score = 52.8 bits (125), Expect = 2e-06
Identities = 120/668 (17%), Positives = 260/668 (38%), Gaps = 89/668 (13%)
Query: 410 SELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYS 469
+E E ++A + Q+ D+ A+ EL + K + ++++ + QA + +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK---NDLQLQVQAEAEGLA 905
Query: 470 KLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQ 529
+E+ +L++ L K EVT++ + +L +K++LED +
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD------ 959
Query: 530 EQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREE 589
++ L+ LA ++E + ++ + A A+L KE+ +L +
Sbjct: 960 -----IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014
Query: 590 ELSA------------LRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637
+L A ++ E Q L+ + +E ++ ++ K L G K A++ I D
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074
Query: 638 ALNQLE--EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695
N+ + + L +L S + + QL+K + A E++ +
Sbjct: 1075 IENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE----- 1129
Query: 696 AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLE-------------EE 742
A S A A + L + ++E ++ G T A + + EE
Sbjct: 1130 AERASRAKAEKQRSDL---SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186
Query: 743 GSL--ENADSTAMRNCLSKIKAIGEEL-----LPRGLDIKQEELGDLVDKEMAATSAAIE 795
+L E +T + + +GE++ + + L+ ++ E+ +D ++A+ +
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-DLASNVETVS 1245
Query: 796 TATARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES-- 851
A +E+M + + + K E +R++ T+ +Q S + R++ E
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ---TESGEFSRQLDEKEA 1302
Query: 852 -----GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVC 906
RG + + + R E I A A+ DL+ R ++EE
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL---REQYEEEQES 1359
Query: 907 SHEIAASTAQL---VAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
E+ + ++ VA + K + D+ +L++A + +A + + E
Sbjct: 1360 KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVE 1411
Query: 963 TDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022
N +S+ T +Q + ++V L L ++++ L KK + W++
Sbjct: 1412 AVNAKCASLEKT---KQRLQNEVEDLML--DVERTNAACAALDKKQRNFDKILAEWKQKC 1466
Query: 1023 EASPPTLQ 1030
E + L+
Sbjct: 1467 EETHAELE 1474
Score = 44.7 bits (104), Expect = 5e-04
Identities = 75/363 (20%), Positives = 153/363 (42%), Gaps = 52/363 (14%)
Query: 370 KDEKDHLIERLY---REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426
++ K L +RL + + A+ +++ QR+ +++ + ++E A L ++
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452
Query: 427 ADDCEFL---RAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELV 479
+ + L + + +E + E ++K RSL +I+ + + + LK + L
Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQ 1512
Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE--------------------- 518
Q +DL + AE K++ + + +E+EK EL+ +LE
Sbjct: 1513 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELN 1572
Query: 519 RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFA 571
++ + RK E+ E ++ LK+ R ++ +Q +L+ +S + +
Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKR---NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629
Query: 572 ELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLAKDQRKMLLVGS 627
E+E + + AA + L+DTQ+ L S E+ QLA +R+ L+ +
Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689
Query: 628 -----RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
R EQ + ++ E L+ + L + TS+ + ++LE SQ
Sbjct: 1690 EIEELRATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747
Query: 683 EDI 685
EDI
Sbjct: 1748 EDI 1750
Score = 44.7 bits (104), Expect = 5e-04
Identities = 60/296 (20%), Positives = 124/296 (41%), Gaps = 49/296 (16%)
Query: 361 NFNSQNGVNKDEKDHL----------------IER----LYREISGLKAQLENMKTE--- 397
N+ + G+ KD + HL +ER L EI L+A LE +
Sbjct: 1648 NYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI 1707
Query: 398 --------SQRVVLQLKGHVS------ELEADLAEQQ----HLRQQAADDCEFLRAELDE 439
S+RV L + S +LE D+++ Q + Q+A + E + + +
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767
Query: 440 LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMA 499
E+ +K Q + + +ER + EQ L+ + E Q L ++ K +
Sbjct: 1768 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ--LALKGGKKQIQKLEARV 1825
Query: 500 RQAQVDLEREKKELEDSLERISDQGQR------KTQEQLEVLESLKQELATSQRELQVLQ 553
R+ + ++E E+K ++++ + +R +T+E + + L+ + Q +++ +
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885
Query: 554 GSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609
E + + A+F +L+ E + A E +++ LR + ++ K+ S E
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 71.2 bits (173), Expect = 5e-12
Identities = 109/507 (21%), Positives = 217/507 (42%), Gaps = 64/507 (12%)
Query: 370 KDEKDHLIERLYR---EISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLR 423
++EK L E+L + EIS L++++E+ + + Q+ + +L+ + ELE ++ ++ R
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135
Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
+A L EL+E+ + E+ A + E+ +K +A Q+ + E+ + + A
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195
Query: 484 DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRKTQEQL 532
LRK AE+ +Q+ ++ + LE+EK E++ ++ ++ + + ++
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255
Query: 533 EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHRE 588
LE EL + + E Q L L + EF+ E+++LVS G
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315
Query: 589 EELSALRKELQD---TQLKLASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQVI 635
+++ L+++L++ + LA +S C L ++Q + L KA +V
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375
Query: 636 Q-------DALNQLEE-----PPLISCAGSADHLLSTV----TSISSCIEQLEKSWSQYL 679
Q DA+ + EE L +A+ + V S+ ++L+ +
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435
Query: 680 ACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETL----AY 735
E + ++ +A C E S EA + G E AY
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEA-RSLGTELFKIKNAY 1494
Query: 736 LASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQ-EELGDLVDKEMAATSAAI 794
SL++ +L+ + +N +I + E++ G I + E++ V++E AA+
Sbjct: 1495 EESLDQLETLKREN----KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550
Query: 795 ETATARIEEMLSKSRAGDTGVKLEVNE 821
E A A +E K ++LE+N+
Sbjct: 1551 EEAEASLEHEEGKI----LRIQLELNQ 1573
Score = 63.9 bits (154), Expect = 7e-10
Identities = 98/462 (21%), Positives = 191/462 (41%), Gaps = 77/462 (16%)
Query: 240 VKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFL 299
+KL FK+ L + + E+F K+KD +S + + L E L
Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 300 RASALSEHISPV-----------VVIPAEASSPDSEPVLEKDDLMDMDASQQNLFD---- 344
+ A +E ++ + + A+ E++ ++ A ++ L D
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 345 --NKFDDIFGSSFSSDPFNFNSQNGV-NKDEK----DHLIERLYREISGL----KAQLEN 393
DD+ + + ++N V N E+ D I +L +E L + L++
Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015
Query: 394 MKTESQRV------VLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRE-D 446
++ E +V ++L+ V +LE L +++ LR +L+ +R+ E D
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-----------DLERAKRKLEGD 1064
Query: 447 TEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD--------------LLRKNAEV 492
+ AQ S+ +IE + Q +++ K + + S L D L + E+
Sbjct: 1065 LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL 1124
Query: 493 TKQVSMARQAQVDLEREKKELEDSLERISDQGQR---KTQEQLEVLESLKQELATSQREL 549
+++ R ++ E+++ +L LE IS++ + T Q+E+ + + E +R+L
Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1184
Query: 550 QVLQGSLE---TSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD------ 600
+ + +L+ T+A A AEL ++ D+L E+E S ++ E+ D
Sbjct: 1185 E--EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242
Query: 601 TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQL 642
T K E MC+ +DQ L K+ E+ Q +N L
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSEL-----KSKEEEQQRLINDL 1279
Score = 60.1 bits (144), Expect = 1e-08
Identities = 95/516 (18%), Positives = 218/516 (42%), Gaps = 77/516 (14%)
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
+E+ ++ G Q + ++ + +R +L+G + + + + ++ +QQ + + E
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE 1092
Query: 437 LDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492
+ L+ + ED + + Q+ + E++ + + E+ + ++ + +DL R+ E+
Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152
Query: 493 TK-----------QVSMARQAQVDLEREKKELED----------SLERISDQGQRKTQEQ 531
++ Q+ M ++ + + ++ +++LE+ +L + + EQ
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212
Query: 532 LEVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587
++ L+ +KQ+L + E+++ L ++ET ++++ N LE + L S +
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS----K 1268
Query: 588 EEELSALRKEL--QDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEP 645
EEE L +L Q +L+ S E S K+ L ++A Q I++ QLEE
Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328
Query: 646 PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705
I + H L + + + QY E + L +++ + +A
Sbjct: 1329 --IKAKNALAHALQSSRHDCDLLRE------QYEEEQESKAELQRALS----KANTEVAQ 1376
Query: 706 GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGE 765
T + + L EA K+ + L + EE NA ++ +++ E
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQR----LQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432
Query: 766 ELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLS--KSRAGDTGVKLEVNE-- 821
+L+ LD+++ A AA++ +++L+ K + +T +LE ++
Sbjct: 1433 DLM---LDVERTN----------AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE 1479
Query: 822 ---------RILGCCTSLMQAIQVLIVASKDLQREI 848
+I + ++ L +K+LQ+EI
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEI 1515
Score = 59.3 bits (142), Expect = 2e-08
Identities = 136/675 (20%), Positives = 268/675 (39%), Gaps = 69/675 (10%)
Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHL-------RQ 424
EK+ L ++ E GL A E + + +QL+ + E+ +++ + ++
Sbjct: 889 EKNDLQLQVQAEAEGL-ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKR 947
Query: 425 QAADDCEFLRAELDELRRQREDTEK----AQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480
+ D+C L+ ++D+L EK + + + + ++ +KL ++ L +
Sbjct: 948 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007
Query: 481 NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRK------- 527
H L +V+ +A++ LE++ +LE SLE+ ++ +RK
Sbjct: 1008 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067
Query: 528 TQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587
QE + +E+ KQ+L ++ + +L++ + E A +L+K+ L +
Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE---QALGIQLQKKIKELQARIEEL 1124
Query: 588 EEELSALR-------KELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN 640
EEE+ A R K+ D +L E + + + + ++ AE Q
Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE--FQKMRR 1182
Query: 641 QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS 700
LEE L A +A S++ EQ++ ++ S + I
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI-------- 1234
Query: 701 DAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKI 760
D +A T +A +L + C+ + L+ L S EEE D TA R L
Sbjct: 1235 DDLASNVETVSKA----KGNLEKMCRTL-EDQLSELKSKEEEQQRLINDLTAQRGRLQ-- 1287
Query: 761 KAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN 820
GE R LD K+ + L + A T IE ++EE + A ++ +
Sbjct: 1288 TESGE--FSRQLDEKEALVSQLSRGKQAFTQ-QIEELKRQLEEEIKAKNALAHALQSSRH 1344
Query: 821 ERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNS-RWTEGLISASKAV 879
+ C L + + + +LQR + ++ A + Y ++ + TE L A K +
Sbjct: 1345 D-----CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399
Query: 880 G---WGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQ-L 935
A V+A + K ++ + E + A+ DK N + L
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459
Query: 936 QQASRGVNQATAGVVASTISGKS---QIEETDNMDFSSM-TLTQIKRQEMDSQVRVLELE 991
+ + + A + AS +S ++ + N S+ L +KR+ + Q + +L
Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1519
Query: 992 NELQKERQKLGELRK 1006
++ + +++ EL K
Sbjct: 1520 EQIAEGGKRIHELEK 1534
Score = 55.5 bits (132), Expect = 3e-07
Identities = 68/284 (23%), Positives = 129/284 (45%), Gaps = 42/284 (14%)
Query: 388 KAQLENMKTESQRVVLQLKGHVSELEADLAEQQH----LRQQAADDCEFLRAELDELRRQ 443
+A LE+ + + R+ L+L SE++ +AE+ L++ E +++ LD R
Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS 1613
Query: 444 REDT----EKAQRSLSEIE-------RKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492
R D +K + L+E+E R A + Y + + + D LR ++
Sbjct: 1614 RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673
Query: 493 TKQVSMARQAQVDLEREKKELEDSLE------RISDQGQRKTQEQLEVLESLKQELATSQ 546
+Q++M + L+ E +EL +LE +I++Q E++++L + L ++
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1733
Query: 547 RELQV----LQGSLETSAQSEANWAAEFA------------ELEKERDSLVSGAAHREEE 590
++L+ +QG +E Q EA A E A EL+KE+D+ +AH E
Sbjct: 1734 KKLETDISQMQGEMEDILQ-EARNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERM 1788
Query: 591 LSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQV 634
+ + ++D QL+L E+ + K Q + L R+ +V
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1832
Score = 52.8 bits (125), Expect = 2e-06
Identities = 120/668 (17%), Positives = 260/668 (38%), Gaps = 89/668 (13%)
Query: 410 SELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYS 469
+E E ++A + Q+ D+ A+ EL + K + ++++ + QA + +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK---NDLQLQVQAEAEGLA 905
Query: 470 KLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQ 529
+E+ +L++ L K EVT++ + +L +K++LED +
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD------ 959
Query: 530 EQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREE 589
++ L+ LA ++E + ++ + A A+L KE+ +L +
Sbjct: 960 -----IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014
Query: 590 ELSA------------LRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637
+L A ++ E Q L+ + +E ++ ++ K L G K A++ I D
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074
Query: 638 ALNQLE--EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695
N+ + + L +L S + + QL+K + A E++ +
Sbjct: 1075 IENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE----- 1129
Query: 696 AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLE-------------EE 742
A S A A + L + ++E ++ G T A + + EE
Sbjct: 1130 AERASRAKAEKQRSDL---SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186
Query: 743 GSL--ENADSTAMRNCLSKIKAIGEEL-----LPRGLDIKQEELGDLVDKEMAATSAAIE 795
+L E +T + + +GE++ + + L+ ++ E+ +D ++A+ +
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-DLASNVETVS 1245
Query: 796 TATARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES-- 851
A +E+M + + + K E +R++ T+ +Q S + R++ E
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ---TESGEFSRQLDEKEA 1302
Query: 852 -----GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVC 906
RG + + + R E I A A+ DL+ R ++EE
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL---REQYEEEQES 1359
Query: 907 SHEIAASTAQL---VAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962
E+ + ++ VA + K + D+ +L++A + +A + + E
Sbjct: 1360 KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVE 1411
Query: 963 TDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022
N +S+ T +Q + ++V L L ++++ L KK + W++
Sbjct: 1412 AVNAKCASLEKT---KQRLQNEVEDLML--DVERTNAACAALDKKQRNFDKILAEWKQKC 1466
Query: 1023 EASPPTLQ 1030
E + L+
Sbjct: 1467 EETHAELE 1474
Score = 44.7 bits (104), Expect = 5e-04
Identities = 75/363 (20%), Positives = 153/363 (42%), Gaps = 52/363 (14%)
Query: 370 KDEKDHLIERLY---REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426
++ K L +RL + + A+ +++ QR+ +++ + ++E A L ++
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452
Query: 427 ADDCEFL---RAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELV 479
+ + L + + +E + E ++K RSL +I+ + + + LK + L
Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQ 1512
Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE--------------------- 518
Q +DL + AE K++ + + +E+EK EL+ +LE
Sbjct: 1513 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELN 1572
Query: 519 RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFA 571
++ + RK E+ E ++ LK+ R ++ +Q +L+ +S + +
Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKR---NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629
Query: 572 ELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLAKDQRKMLLVGS 627
E+E + + AA + L+DTQ+ L S E+ QLA +R+ L+ +
Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689
Query: 628 -----RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
R EQ + ++ E L+ + L + TS+ + ++LE SQ
Sbjct: 1690 EIEELRATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747
Query: 683 EDI 685
EDI
Sbjct: 1748 EDI 1750
Score = 44.7 bits (104), Expect = 5e-04
Identities = 60/296 (20%), Positives = 124/296 (41%), Gaps = 49/296 (16%)
Query: 361 NFNSQNGVNKDEKDHL----------------IER----LYREISGLKAQLENMKTE--- 397
N+ + G+ KD + HL +ER L EI L+A LE +
Sbjct: 1648 NYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI 1707
Query: 398 --------SQRVVLQLKGHVS------ELEADLAEQQ----HLRQQAADDCEFLRAELDE 439
S+RV L + S +LE D+++ Q + Q+A + E + + +
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767
Query: 440 LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMA 499
E+ +K Q + + +ER + EQ L+ + E Q L ++ K +
Sbjct: 1768 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ--LALKGGKKQIQKLEARV 1825
Query: 500 RQAQVDLEREKKELEDSLERISDQGQR------KTQEQLEVLESLKQELATSQRELQVLQ 553
R+ + ++E E+K ++++ + +R +T+E + + L+ + Q +++ +
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885
Query: 554 GSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609
E + + A+F +L+ E + A E +++ LR + ++ K+ S E
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 70.9 bits (172), Expect = 6e-12
Identities = 148/715 (20%), Positives = 288/715 (40%), Gaps = 106/715 (14%)
Query: 369 NKDEKDHLIERLYREISGLK------AQLENMKTESQRVVLQLKGHVSELEADLAEQQHL 422
N D + ++ +I LK AQ N S V L S+L ++AE Q
Sbjct: 570 NDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQ 629
Query: 423 -------RQQAADDCEFLRAELDELRRQR----EDTEKAQRSLSEIERKAQAN------- 464
+Q ++ E +RA L+ELR Q E+ Q+ L E E + + N
Sbjct: 630 LQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQV 689
Query: 465 ----EQRYSKLKEKYSELVQNHADL-------LRKNAEVTKQVSMARQAQVDLEREKKEL 513
EQ +++++ +L + H +L R+ + +++ A+Q DL K+E
Sbjct: 690 KMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ 749
Query: 514 EDSL---------------ERIS--DQGQRKTQEQLEV-LESLKQELATSQRELQVLQGS 555
ED L E +S DQ K +EQ + L++L++ + + + ++VL
Sbjct: 750 EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR 809
Query: 556 LETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQL 615
TS Q +A L++E + L + E ++ L+++++D + A +E++ +
Sbjct: 810 SNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKY 869
Query: 616 AKDQRKM--LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673
+ R++ LV +RK ++ + + + E L + G+ +S +++ +
Sbjct: 870 EGEIRQLEEALVHARKEEKEAV--SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESE 927
Query: 674 SWSQYLACPEDISG----LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYG 729
Q ++ L +I L +D + T+ L E + L E K+
Sbjct: 928 QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTL----ELQNQLDE-YKEKN 982
Query: 730 RETLAYLASLEEEGSLENADS--TAMRNCLSKIKAIGEEL--LPRGLD-------IKQEE 778
R LA + +E +LE S TAM+ +++ + EEL R D + ++
Sbjct: 983 RRELAEMQRQLKEKTLEAEKSRLTAMK-MQDEMRLMEEELRDYQRAQDEALTKRQLLEQT 1041
Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLI 838
L DL + E+ A S + + +++M K + ++ E N L L + I
Sbjct: 1042 LKDL-EYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDL-----LSERISRSR 1095
Query: 839 VASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG 898
+ L+ E+++ + R + L S+ + + LVVQ
Sbjct: 1096 EQMEQLRNELLQERAARQDLECDKISLERQNKDL--KSRIIHLEGSYRSSKEGLVVQMEA 1153
Query: 899 KFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958
+ EL + + + + + A LQ ++R + + +V
Sbjct: 1154 RIAEL------------------EDRLESEERDRANLQLSNRRLERKVKELVMQV--DDE 1193
Query: 959 QIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAG 1013
+ TD D S+ L +KRQ +++ + LE+ +K +++L E + L G
Sbjct: 1194 HLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQG 1248
Score = 57.0 bits (136), Expect = 9e-08
Identities = 63/276 (22%), Positives = 121/276 (43%), Gaps = 33/276 (11%)
Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENM------KTESQRVVLQLKGHVSEL--EAD 415
SQ+ +E L +RL L+ LE + + + Q + L+ +SE+ E D
Sbjct: 656 SQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELD 715
Query: 416 LAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY 475
A++ R++ A ++EL + ++D + + E E + E+ + LK
Sbjct: 716 SAKRSEDREKGA--------LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGAL 767
Query: 476 SELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVL 535
E V +H + K E A + V+ + E+ S S+Q Q T+ ++++L
Sbjct: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 536 -----------ESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGA 584
E L++ +A QR+++ L+G + ++ + E +LE ++LV
Sbjct: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE---EALVHAR 884
Query: 585 AHREEELS---ALRKELQDTQLKLASTEESMCQLAK 617
+E +S AL EL+ Q L+ T + QL++
Sbjct: 885 KEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSE 920
Score = 57.0 bits (136), Expect = 9e-08
Identities = 111/551 (20%), Positives = 212/551 (38%), Gaps = 76/551 (13%)
Query: 317 EASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHL 376
E SS D E K+ DA Q L ++ + + N + Q+ + + L
Sbjct: 770 EVSSHDQEMDKLKEQY---DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKL 826
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
++ ++ G +LE + QR + LKG D A+ + ++ + L
Sbjct: 827 LQEENEKLQGRSEELERRVAQLQRQIEDLKG-------DEAKAKETLKKYEGEIRQLEEA 879
Query: 437 LDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQV 496
L R++ ++ A+R+L AQ N S+ Q L K E ++Q
Sbjct: 880 LVHARKEEKEAVSARRALENELEAAQGN----------LSQTTQEQKQLSEKLKEESEQK 929
Query: 497 SMARQAQVDLEREKKELEDSLERI----SDQGQRKTQEQLEVLESLKQELATSQRELQVL 552
R+ + ++E E+ L ++E++ +D + LE+ L + ++REL +
Sbjct: 930 EQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEM 989
Query: 553 QGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD---TQLKLASTE 609
Q L+ LE E+ L A ++E+ + +EL+D Q + +
Sbjct: 990 QRQLKEKT------------LEAEKSRLT--AMKMQDEMRLMEEELRDYQRAQDEALTKR 1035
Query: 610 ESMCQLAKD-----QRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSI 664
+ + Q KD + K L R + ++D ++QL E L ++D L ++
Sbjct: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQL-EMELEEERNNSDLLSERISRS 1094
Query: 665 SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEA 724
+EQL Q A +D+ S+ I H E
Sbjct: 1095 REQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIH----------------LEG 1138
Query: 725 CKQYGRETL-----AYLASLEEEGSLENADSTAM----RNCLSKIKAIGEELLPRGLDIK 775
+ +E L A +A LE+ E D + R K+K + ++ L +
Sbjct: 1139 SYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT 1198
Query: 776 QEELGDLVDKEMAATSAAIETATARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQA 833
++ D + + A +E A I+ + S K + ++++NE + G S+ +
Sbjct: 1199 DQK--DQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKD 1256
Query: 834 IQVLIVASKDL 844
+++ + SK L
Sbjct: 1257 LRLKKLPSKVL 1267
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 70.5 bits (171), Expect = 8e-12
Identities = 116/529 (21%), Positives = 228/529 (43%), Gaps = 68/529 (12%)
Query: 370 KDEKDHLIERLYR---EISGLKAQLENMKTES---QRVVLQLKGHVSELEADLAEQQHLR 423
+++K + E+L + E+S L+A++++ + S Q+ + +L+ + ELE ++ + LR
Sbjct: 1074 ENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR 1133
Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
+ L EL+E+ + E+ A + E+ +K +A Q+ + E+ + + A
Sbjct: 1134 AKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193
Query: 484 DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERISD--QGQRKTQEQLE--- 533
LRK AE+ +Q+ ++ + LE+EK EL+ ++ ++ + K++ +E
Sbjct: 1194 ATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTC 1253
Query: 534 --VLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEEL 591
V + + A +++ Q++ A+ + E + +E++SL+S ++ L
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQ-NGELSHRVEEKESLISQLTKSKQAL 1312
Query: 592 SALRKEL-----QDTQLKLA-----STEESMCQLAKDQ-------RKMLLVGSRKAAEQV 634
+ +EL ++T+ K A + C L ++Q + L KA +V
Sbjct: 1313 TQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372
Query: 635 IQ-------DALNQLEE-----PPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682
Q DA+ + EE L A+ +T T+ S C LEK+ +
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE--NTETANSKC-ASLEKTKQRLQGEV 1429
Query: 683 EDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEE 742
ED+ L +H A L D + KQ E+ A L + ++E
Sbjct: 1430 EDLMRDLER------------SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477
Query: 743 GSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIE 802
+ + MRN ++ E L ++ QEE+ DL + ++A T ++ A
Sbjct: 1478 SRSLSTELFKMRNAYEEVVDQLETLRRENKNL-QEEISDLTE-QIAETGKNLQEAEK--T 1533
Query: 803 EMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQV-LIVASKDLQREIVE 850
+ L + D V LE E L S + +Q+ L +L R+++E
Sbjct: 1534 KKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIE 1582
Score = 69.7 bits (169), Expect = 1e-11
Identities = 141/690 (20%), Positives = 271/690 (39%), Gaps = 87/690 (12%)
Query: 383 EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQ----QHLRQQAADDCEFLRAELD 438
E ++ LE + + L+ ++ A+L EQ Q ++Q+ + L+ E+D
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233
Query: 439 ELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ-------NHADLLRKNAE 491
++ + E +S S IER + E ++S++K K + Q A L +N E
Sbjct: 1234 DMA---SNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGE 1290
Query: 492 VTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQV 551
++ +V L + K+ L LE + +R+ +E+ + ++ L +S+ + +
Sbjct: 1291 LSHRVEEKESLISQLTKSKQALTQQLEEL----KRQMEEETKAKNAMAHALQSSRHDCDL 1346
Query: 552 LQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHREEELSALRKEL-QDTQLKLA 606
L+ E +++A ++ E R + A R EEL +K+L Q Q
Sbjct: 1347 LREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1406
Query: 607 STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISS 666
+TE + + A ++ +++ + ++D + LE +CA + ++
Sbjct: 1407 NTETANSKCASLEK------TKQRLQGEVEDLMRDLERSHT-ACATLDKKQRNFDKVLAE 1459
Query: 667 CIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAP----PEPADSLT 722
++L++S ++ A ++ L + + + + + T LR E LT
Sbjct: 1460 WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET--LRRENKNLQEEISDLT 1517
Query: 723 EACKQYGR--------------ETLAYLASLEE-EGSLENADSTAMRNCLSKIKAIGEEL 767
E + G+ E +LEE EGSLE+ +S +R L + E
Sbjct: 1518 EQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSE-- 1575
Query: 768 LPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-----LSKSRAGDTG---VKLEV 819
L R + K EE+ L A A A I L K GD ++L
Sbjct: 1576 LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGH 1635
Query: 820 NERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYA----KNSRWTEGLISA 875
+ R + ++ +Q + KD Q + ++ R KE A +N E L
Sbjct: 1636 SNRQMAETQKHLRTVQGQL---KDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692
Query: 876 SKAVGWGATV-------MVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAA-------- 920
A+ ++DA+D V + L+ ++ A AQ A
Sbjct: 1693 KVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQES 1752
Query: 921 --SKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNM--DFSSMTLTQI 976
++ KA K + A + + + +A + + + +++ + + + L
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1812
Query: 977 KRQEMDSQVRVLELENELQKERQKLGELRK 1006
K+Q + RV ELENEL E+++ E K
Sbjct: 1813 KKQIQKLENRVRELENELDVEQKRGAEALK 1842
Score = 64.3 bits (155), Expect = 6e-10
Identities = 145/730 (19%), Positives = 287/730 (39%), Gaps = 132/730 (18%)
Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437
E + E+ K LE+ + +R + L+ ++++E + ++ + +++ L +
Sbjct: 934 EEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENI 993
Query: 438 DELRRQREDTEKA-QRSLSEIE-RKAQAN---------EQRYSKLKEKYSELVQNHADLL 486
+L ++++ ++A Q++L +++ + + N EQ+ L+ + + ADL
Sbjct: 994 SKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLE 1053
Query: 487 RKNAEVTKQVSMARQAQVDLEREKKELEDSLE-----------RISD------QGQRKTQ 529
R ++ + M++++ +DLE +K+++E+ L+ +I D Q Q+K +
Sbjct: 1054 RAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIK 1113
Query: 530 EQLEVLESLKQELATSQ--------------RELQVLQGSLE-----TSAQSEANWAAEF 570
E +E L++E+ REL+ + LE TSAQ E N E
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKRE- 1172
Query: 571 AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKA 630
AE +K R L E + LRK+ D+ +L +++ ++ K L +
Sbjct: 1173 AEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRV-----KQKLEKEKSE 1227
Query: 631 AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLH 690
+ I D + +E L + ++I +E +S+ A E + L+H
Sbjct: 1228 LKMEIDDMASNIEA------------LSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275
Query: 691 SITL-LAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYL-ASLEEEGSLENA 748
+ + A L + +G + E S KQ + L L +EEE +NA
Sbjct: 1276 DLNMQKARLQTQ---NGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNA 1332
Query: 749 DSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL------VDKEMAATSAAIET-ATARI 801
+ A+++ +LL + +QE +L + E+A ET A R
Sbjct: 1333 MAHALQSSRHDC-----DLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387
Query: 802 EEM--LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTAS-- 857
EE+ K A E E C SL + Q L +DL R++ S A+
Sbjct: 1388 EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLD 1447
Query: 858 --PKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTA 915
+ F + W + L + + + + + R +EE++
Sbjct: 1448 KKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV----------- 1496
Query: 916 QLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEET-DNMDFSSMTLT 974
L L++ ++ + + + + QI ET N+ + T
Sbjct: 1497 --------------DQLETLRRENKNLQEEISDLT-------EQIAETGKNLQEAEKTKK 1535
Query: 975 QIKRQEMDSQVRVLELENELQKERQKL-----------GELRKKHYELAGVAEGWEEGTE 1023
+++++ D QV + E+E L+ E K+ EL +K E E + ++
Sbjct: 1536 LVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ 1595
Query: 1024 ASPPTLQEVV 1033
+ LQ V+
Sbjct: 1596 RAAEALQSVL 1605
Score = 63.5 bits (153), Expect = 1e-09
Identities = 114/679 (16%), Positives = 286/679 (42%), Gaps = 82/679 (12%)
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436
+E+ ++ G Q + ++ + +R +L+G + + + + ++ +QQ + + E
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090
Query: 437 LDELRRQREDTE-----------KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485
L +L+ + +D + + Q + E+E + +A +K++++ S+L + ++
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI 1150
Query: 486 LRKNAE----VTKQVSMARQAQVDLEREKKELED----------SLERISDQGQRKTQEQ 531
+ E + Q+ M ++ + + ++ +++LE+ +L + + EQ
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ 1210
Query: 532 LEVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587
++ L+ +KQ+L + EL++ + ++E ++S++N +E + + + +
Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA----K 1266
Query: 588 EEELSALRKELQDTQLKLASTEESMCQLAKDQRKML--LVGSRKAAEQVIQDALNQLEEP 645
+E+ + L +L + +L + + +++ ++ L S++A Q +++ Q+EE
Sbjct: 1267 DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326
Query: 646 PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705
+ H L +S C + L + + + ++ L + +A
Sbjct: 1327 --TKAKNAMAHALQ--SSRHDC-DLLREQYEEEQEAKAELQRALSK-------ANSEVAQ 1374
Query: 706 GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGE 765
T + + L EA K+ + L EE N+ ++ +++ E
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQR----LQEAEENTETANSKCASLEKTKQRLQGEVE 1430
Query: 766 ELLPRGLDIKQEELGDL------VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV 819
+L+ R L+ L DK +A ++ + A +E +SR+ T +
Sbjct: 1431 DLM-RDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMR 1489
Query: 820 N--ERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASK 877
N E ++ +L + + L DL +I E+G+ ++ T+ L+ K
Sbjct: 1490 NAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK--------TKKLVEQEK 1541
Query: 878 AVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQ 937
+ + A V+G + EE + ++ S + KV +KD + QL++
Sbjct: 1542 S-------DLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKV-IEKDE-EIEQLKR 1592
Query: 938 ASRGVNQATAGVVASTISGKS---QIEETDNMDFSSM--TLTQIKRQEMDSQVRVLELEN 992
S+ +A V+ + I ++ ++++ D + M L RQ ++Q + ++
Sbjct: 1593 NSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG 1652
Query: 993 ELQKERQKLGELRKKHYEL 1011
+L+ + L + + + +L
Sbjct: 1653 QLKDSQLHLDDALRSNEDL 1671
Score = 60.5 bits (145), Expect = 8e-09
Identities = 108/512 (21%), Positives = 204/512 (39%), Gaps = 74/512 (14%)
Query: 370 KDEKDHLIERLYREISGLKAQLENMKTES-QRVVLQLKGHVSELEADLAEQQHLRQQAAD 428
++ K L +RL + N K S ++ +L+G V +L DL E+ H D
Sbjct: 1391 EEAKKKLAQRLQEAEEN--TETANSKCASLEKTKQRLQGEVEDLMRDL-ERSHTACATLD 1447
Query: 429 DCEF--------LRAELDELRRQREDTEKAQRSLS-----------EIERKAQANEQRYS 469
+ + +LDE + + E +K RSLS E+ + + +
Sbjct: 1448 KKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENK 1507
Query: 470 KLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE----------- 518
L+E+ S+L + A+ + E K + Q + DL+ +E+E SLE
Sbjct: 1508 NLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL 1567
Query: 519 ---RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAA 568
++ + RK E+ E +E LK+ SQR + LQ L+ +S +
Sbjct: 1568 ELSQVKSELDRKVIEKDEEIEQLKR---NSQRAAEALQSVLDAEIRSRNDALRLKKKMEG 1624
Query: 569 EFAELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLA-KDQRKML 623
+ E+E + A ++ L ++ +L+D+QL L S E+ QLA ++R L
Sbjct: 1625 DLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGL 1684
Query: 624 LVGSRKAAEQVIQ--DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
L+ + + ++ + +L E L+ + L S TS+ + ++LE +Q C
Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQ---C 1741
Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSL-TEACKQYGRETLAYLASLE 740
++ + AI A E S E K+ +T+ L
Sbjct: 1742 QAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL---- 1797
Query: 741 EEGSLENADSTAMRNCLSKIKAIGEEL--LPRGLDIKQEELGDLVD---------KEMAA 789
+ L+ A+ A++ +I+ + + L LD++Q+ + + KEM
Sbjct: 1798 -QHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTY 1856
Query: 790 TSAAIETATARIEEMLSKSRAGDTGVKLEVNE 821
+ R+++++ K +A K + E
Sbjct: 1857 QAEEDHKNILRLQDLVDKLQAKVKSYKRQAEE 1888
Score = 49.7 bits (117), Expect = 1e-05
Identities = 54/249 (21%), Positives = 114/249 (45%), Gaps = 27/249 (10%)
Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441
+E++ +K E K E R + K ++ + L E+ L+ Q +++E + L
Sbjct: 851 KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQ-------VQSETENLM 903
Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501
E E +S +E K + +R + +E SELV +L K + + + +
Sbjct: 904 DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963
Query: 502 AQVDLEREKKELEDSLERISDQG-------QRKTQEQLEVLESLKQELATSQRELQVLQG 554
+E+EK E+ ++ +S++ + T+E+ + E+ +Q L Q E + G
Sbjct: 964 TLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNG 1023
Query: 555 SLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA-LRKELQDTQLKLASTEESMC 613
++ + A+LE++ D L G+ +E++L A L + + + L ++ES+
Sbjct: 1024 LIKIN-----------AKLEQQTDDL-EGSLEQEKKLRADLERAKRKLEGDLKMSQESIM 1071
Query: 614 QLAKDQRKM 622
L D++++
Sbjct: 1072 DLENDKQQI 1080
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 69.7 bits (169), Expect = 1e-11
Identities = 143/669 (21%), Positives = 266/669 (39%), Gaps = 75/669 (11%)
Query: 373 KDHLIER-LYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQ-QHLRQQAADDC 430
KD L R L E+ K ++E +R + LKG + E A ++ +H+RQQ D
Sbjct: 467 KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526
Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
E LR + + + E ++ +S + R Q + S+ + + Q + + LR
Sbjct: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586
Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQ 550
+ Q+ M ++ ++E E E + L+R +Q + + +V E LK+EL +Q EL+
Sbjct: 587 QELLQLRMEKE---EMEEELGEKIEVLQRELEQARASAGDTRQV-EVLKKELLRTQEELK 642
Query: 551 VLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDT--QLKLAST 608
LQ E +Q A + ELEK+ +++ A R EL +LQ T QL+
Sbjct: 643 ELQA--ERQSQEVAGRHRD-RELEKQL-AVLRVEADRGRELEEQNLQLQKTLQQLRQDCE 698
Query: 609 EESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLE---------EPPLISCAGSADHLLS 659
E S ++ + +L R A E +++ + + E L G D +
Sbjct: 699 EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEA 758
Query: 660 TVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPAD 719
+ +++LE Q L A + A L A E A
Sbjct: 759 VEARLRDKLQRLEAEKQQL------------EEALNASQEEEGSLAAAKRALEARLEEAQ 806
Query: 720 SLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEEL 779
+ G+E +LEEEG R L + KA EE R LD + L
Sbjct: 807 ---RGLARLGQEQQTLNRALEEEGK--------QREVLRRGKAELEE-QKRLLDRTVDRL 854
Query: 780 GDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN------ERILGCCTSLMQA 833
++K + A++ A++E+ K+R + + E+ G + L
Sbjct: 855 NKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDE 914
Query: 834 IQVLIVASKDLQRE-----------------IVESGRGTASPKEFYAKNSRWTEGLISAS 876
IQ L A + Q E + + ++ A+ + E +S
Sbjct: 915 IQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRL 974
Query: 877 KA-VGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQL 935
+ + + D V +GR + ++L + S Q + K+ ++ + +L
Sbjct: 975 ETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQ-ERSARQDLECDKISLERQNKDLKTR 1033
Query: 936 QQASRGVNQATAGVVASTISGKSQ-IEETDNMDFSSMTLTQIKRQEMDSQVRVLELENEL 994
+S G + +A + S + ++Q ++E + T+ Q ++++ +V+ EL ++
Sbjct: 1034 LASSEGFQKPSASL--SQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVK--ELSIQI 1089
Query: 995 QKERQKLGE 1003
+ ERQ + +
Sbjct: 1090 EDERQHVND 1098
Score = 56.2 bits (134), Expect = 2e-07
Identities = 56/219 (25%), Positives = 95/219 (43%), Gaps = 48/219 (21%)
Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKG---HVSELEADLAEQQHLRQ-------QAA 427
E L + + GL+ + EN K QLKG VS LE +L E+++ + +
Sbjct: 937 ELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGR 996
Query: 428 DDCEFLRAELDELRRQREDTE------------------------KAQRSLSEIERKAQA 463
D + LR EL + R R+D E K SLS++E + Q
Sbjct: 997 DQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056
Query: 464 NEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVD-----------LEREKKE 512
++R + + + L + L RK E++ Q+ RQ D L+R+ E
Sbjct: 1057 LQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDE 1116
Query: 513 LEDSLERISD---QGQRKTQEQLEVLESLKQELATSQRE 548
E+ +ER+ + QR+ +EQ EV E L+ + + +++
Sbjct: 1117 AEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKD 1155
Score = 55.8 bits (133), Expect = 2e-07
Identities = 71/341 (20%), Positives = 136/341 (39%), Gaps = 28/341 (8%)
Query: 328 EKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGL 387
E ++ + Q++F +D+ + + + ++E IE L RE+
Sbjct: 560 ELEETSEETGHWQSMFQKNKEDLRATK--QELLQLRMEKEEMEEELGEKIEVLQRELEQA 617
Query: 388 KA------QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE-- 439
+A Q+E +K E R +LK +E ++ +H ++ LR E D
Sbjct: 618 RASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGR 677
Query: 440 ------------LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487
L++ R+D E+A ++ E +A QR + ++ E + + + R
Sbjct: 678 ELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR 737
Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
+ + +Q+ R E + L D L+R+ + Q + +E L + + LA ++R
Sbjct: 738 RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ-QLEEALNASQEEEGSLAAAKR 796
Query: 548 ELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603
L+ Q L Q + E K+R+ L G A EE+ L + +
Sbjct: 797 ALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNK 856
Query: 604 KLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644
+L E Q A Q + L ++ A + + DA Q ++
Sbjct: 857 ELEKIGEDSKQ-ALQQLQAQLEDYKEKARREVADAQRQAKD 896
Score = 44.7 bits (104), Expect = 5e-04
Identities = 138/672 (20%), Positives = 250/672 (37%), Gaps = 109/672 (16%)
Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDC 430
DE+ ++L GL+ QLE KTE S L+ L ++ QQ+ +
Sbjct: 376 DEEVKKRQKLEPSQVGLERQLEE-KTEE----------CSRLQELLERRKGEAQQSNKEL 424
Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
+ ++ LD+ R E L + Q E L + E + ++L
Sbjct: 425 QNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQ 484
Query: 491 EVTKQVSMARQAQVDLEREKKE----LEDSLERISDQGQRKTQEQLEVLESLKQELATSQ 546
V +Q+ + + L+ KE + +E + Q QR T++ ++ Q+ A +
Sbjct: 485 RVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLE 544
Query: 547 RELQV-------LQGSLETSAQSEANWAAEF----AELEKERDSLVSGAAHRE------- 588
E Q LQ LE +++ +W + F +L + L+ +E
Sbjct: 545 AERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG 604
Query: 589 EELSALRKELQDTQLKLAST---EESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEP 645
E++ L++EL+ + T E +L + Q ++ + + + +++V ++ E
Sbjct: 605 EKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEK 664
Query: 646 PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705
L AD + QL+K+ Q E+ S ++A + +
Sbjct: 665 QLAVLRVEADR----GRELEEQNLQLQKTLQQLRQDCEEAS----KAKMVAEAEATVLGQ 716
Query: 706 ---GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLEN---ADSTAMRNCLSK 759
T LR E D ++ R L L+E L + A +R+ L +
Sbjct: 717 RRAAVETTLRETQEEND-------EFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR 769
Query: 760 IKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV 819
++A ++ L L+ QEE G L AA A+E AR+EE ++ G + +
Sbjct: 770 LEA-EKQQLEEALNASQEEEGSL-----AAAKRALE---ARLEE--AQRGLARLGQEQQT 818
Query: 820 NERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAV 879
R L + QRE++ RG A +E R + L + +
Sbjct: 819 LNRAL---------------EEEGKQREVLR--RGKAELEEQKRLLDRTVDRLNKELEKI 861
Query: 880 GWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQ--- 936
G D+ + Q + + E+ + A + +A+K S L++LQ
Sbjct: 862 G------EDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915
Query: 937 ----------QASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVR 986
QA R + ++A + G Q E +N S RQ + +
Sbjct: 916 QRLRQALQASQAERDTARLDKELLAQRLQGLEQ--EAENKKRSQ---DDRARQLKGLEEK 970
Query: 987 VLELENELQKER 998
V LE EL +E+
Sbjct: 971 VSRLETELDEEK 982
Score = 41.6 bits (96), Expect = 0.004
Identities = 128/603 (21%), Positives = 224/603 (37%), Gaps = 94/603 (15%)
Query: 477 ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE 536
EL + +L RK E K+ +QV LER+ +E + R+ E+LE
Sbjct: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQ-----------ELLE 411
Query: 537 SLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRK 596
K E S +ELQ ++ L+ + EL+ + + +E L K
Sbjct: 412 RRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKE----VLLK 467
Query: 597 ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGS-AD 655
+L +T ++ + +L G ++ EQ+ +L E L + G+ +
Sbjct: 468 DLLET---------------RELLEEVLEGKQRVEEQL------RLRERELTALKGALKE 506
Query: 656 HLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPP 715
+ S + +Q ++ Q +D + H++ A+ G L
Sbjct: 507 EVASRDQEVEHVRQQYQRDTEQLRRSMQDAT-QDHAVLEAERQKMSALVRGLQRELEETS 565
Query: 716 EPA---DSLTEACKQYGRETLAYLASL-----EEEGSLENADSTAMRNCLSKIKAIGE-- 765
E S+ + K+ R T L L E E L R + G+
Sbjct: 566 EETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTR 625
Query: 766 --ELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRA-----GDTGVKLE 818
E+L + L QEEL KE+ A + E A + L K A D G +LE
Sbjct: 626 QVEVLKKELLRTQEEL-----KELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELE 680
Query: 819 VNERILGCCTSLMQAIQVLIVASKD---LQREIVESGRGTASP----KEFYAKNSRW--- 868
E+ L +L Q Q ASK + E G+ A+ +E +N +
Sbjct: 681 --EQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRR 738
Query: 869 ----------TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLV 918
T GL+ +AV + D + + + EE + S E S A
Sbjct: 739 ILGLEQQLKETRGLVDGGEAV---EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK 795
Query: 919 AASKVKADKDSPNLAQLQQASRGVNQA--TAGVVASTI-SGKSQIEETDNM-----DFSS 970
A + + ++ LA+L Q + +N+A G + GK+++EE + D +
Sbjct: 796 RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN 855
Query: 971 MTLTQIKRQEMDS-QVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTL 1029
L +I + Q +LE+ +K R+++ + +++ + A AE G +
Sbjct: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915
Query: 1030 QEV 1032
Q +
Sbjct: 916 QRL 918
Score = 36.2 bits (82), Expect = 0.16
Identities = 76/348 (21%), Positives = 135/348 (38%), Gaps = 40/348 (11%)
Query: 145 LLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLE-CELNLFQTVF 203
L R K E + + +++L++ GE QL ++ DY E +
Sbjct: 833 LRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQR 892
Query: 204 NSLDMSRSVSVTAAGQCRLAPLIQVI---LDCSHLYDYTVKLLFKLHSCLPADTLQGHRD 260
+ D + T+ G RL IQ + L S T +L L A LQG
Sbjct: 893 QAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTA----RLDKELLAQRLQG--- 945
Query: 261 RFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASS 320
+EQ + K RS + R Q+ L E + L E + V ++ +
Sbjct: 946 --LEQEAENKK---RSQD----DRARQLKGLEEKVSRL--ETELDEEKNTVELLTDRVNR 994
Query: 321 PDSEPVLEKDDLMDMDASQQNLFDNKFD------DIFGSSFSSDPFNFNSQNGVNKDEKD 374
+ + +LM +++Q+L +K D+ SS+ F S + + ++
Sbjct: 995 GRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQN 1054
Query: 375 HLI-ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL 433
L+ ERL E E KT Q +L+ V EL + ++ RQ D + L
Sbjct: 1055 QLLQERLQAE--------EREKTVLQSTNRKLERKVKELSIQIEDE---RQHVNDQKDQL 1103
Query: 434 RAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQN 481
+ L+RQ ++ E+ L + +KAQ + ++ E+ +++
Sbjct: 1104 SLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKS 1151
>gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens]
Length = 284
Score = 68.9 bits (167), Expect = 2e-11
Identities = 74/297 (24%), Positives = 131/297 (44%), Gaps = 42/297 (14%)
Query: 326 VLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYR-EI 384
+L+ D +D ++Q D K + D V++DE+D ++E L++ E
Sbjct: 10 MLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAED 69
Query: 385 SGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQR 444
S L A+ K E+ L + + E E D A+++ L L +L
Sbjct: 70 SLLAAEEAAAKAEADVASLNRRIQLVEEELDRAQER------------LATALQKLEEAE 117
Query: 445 EDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQV 504
+ ++++R + IE +AQ +E++ + + E D RK EV +++ +
Sbjct: 118 KAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIES--- 174
Query: 505 DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQ-----------RELQVLQ 553
DLER ++ E +S+ R+ +EQL +++ + L ++ E++VL
Sbjct: 175 DLERAEERAE-----LSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLS 229
Query: 554 GSLETSAQSEANWAAEFAE-----LEKERDSLVSGAAHREEELSALRKELQDTQLKL 605
L+ EA AEFAE LEK D L AH +EE ++ + L T L+L
Sbjct: 230 DKLK-----EAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLEL 281
>gi|4504063 golgin 97 [Homo sapiens]
Length = 767
Score = 68.9 bits (167), Expect = 2e-11
Identities = 129/601 (21%), Positives = 244/601 (40%), Gaps = 86/601 (14%)
Query: 483 ADLLRKNAEVTK---QVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLK 539
+ LLR+N ++ K ++S + +L++ K++LE +LE+ D RK QEQ E ++ +
Sbjct: 58 SQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANR 117
Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----------GAAHREE 589
++A +G A+ + W+ + +LEKE++ L + R +
Sbjct: 118 AKMA---------EGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRD 168
Query: 590 ELSAL----RKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAE-----QVIQDALN 640
E+ L ++EL + L EES+ ++ ++ SR E Q+ D
Sbjct: 169 EMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQ 228
Query: 641 QLEEPP--LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698
+LEE + DH++++ T S I LE+ + A + +S L +T
Sbjct: 229 KLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQE 288
Query: 699 TSDAIAH--GATTCLRAPPEPADSLTEACKQYGRE-TLA----------YLASLEEEGSL 745
D I H L E S E ++ +E TLA LA+ +
Sbjct: 289 KEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKA 348
Query: 746 ENADSTAMRNCLSKIKAIGEELLP-RGLDIKQE-----------ELGDLVDKEMAATSAA 793
N T +R ++A E+L +G+ QE E + + +A
Sbjct: 349 INTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQF 408
Query: 794 IETATARIEEM--LSKSRAGDT-----GVKL--EVNERILGCCTSLMQAIQVLIVASKDL 844
+E A ++ L ++RA D G++ + N + C +++Q K L
Sbjct: 409 LERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKL 468
Query: 845 -----QREIVESGRGTA------SPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLV 893
QREIV A +EF + + T + + + V++ +
Sbjct: 469 KEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEI 528
Query: 894 VQGRGKFEELMVCSHEIAAS-----TAQLVAASKVKADKDSPNL-AQLQQASRGVNQA-- 945
+Q ++ H++ A T + A+ V +D L LQ + VN++
Sbjct: 529 LQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHV 588
Query: 946 TAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELR 1005
T+ + + T N + +M LTQ+++++ D + ++LE +++ +Q++ ELR
Sbjct: 589 TSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELR 648
Query: 1006 K 1006
K
Sbjct: 649 K 649
Score = 56.2 bits (134), Expect = 2e-07
Identities = 57/220 (25%), Positives = 103/220 (46%), Gaps = 26/220 (11%)
Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAA-------DD 429
+E RE+ E +S+ +V + + EL A E H++QQA +
Sbjct: 352 LETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLER 411
Query: 430 CEFLRAELDELRRQRE-DTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRK 488
+ L A++ L R R D A++ + ++E++ A ++ + +Y +QNH L+K
Sbjct: 412 TQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKE----CRNEYERSLQNHQFELKK 467
Query: 489 NAEVTKQ---VSMA-RQAQVDLEREKKELED---SLERISDQGQRKTQEQLEVLESLKQE 541
E Q VS+A QA ++ ++++E + +L I D+ ++ +E+ EVL +QE
Sbjct: 468 LKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQE 527
Query: 542 LATSQR-------ELQVLQGSLETSAQSEANWAAEFAELE 574
+ +R ++ LQ LE +A AA AE E
Sbjct: 528 ILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQE 567
Score = 55.5 bits (132), Expect = 3e-07
Identities = 69/319 (21%), Positives = 136/319 (42%), Gaps = 22/319 (6%)
Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429
+DE D L +E+S +K L + ++ +L+ EL E + Q ++D
Sbjct: 167 RDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSD- 225
Query: 430 CEFLRAELDELRRQREDTEKAQ----RSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485
L +L+EL+R E+ + S + E K A EQ+ +L+ +L DL
Sbjct: 226 ---LSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQL---SIDL 279
Query: 486 LRKNAEVTKQVSMARQAQVDLEREKKELEDSL---ERISDQGQRKTQEQLEVLESLKQEL 542
+ AE ++ + Q + +K LE +L E + + + KT + + LE +Q+L
Sbjct: 280 QKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAE-QNLEDTRQQL 338
Query: 543 ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ 602
++ +LET + E ++ +V+ + +EL+A +E Q
Sbjct: 339 LAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQ 398
Query: 603 LKLASTEESMCQ--LAKDQRKMLLVGSRKAAEQVIQDALNQLEE--PPLISCAGSADHLL 658
+ + E+ + A + + + L +R A + + + QLE+ L C + L
Sbjct: 399 QQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSL 458
Query: 659 STVTSISSCIEQLEKSWSQ 677
+ +++L++ WSQ
Sbjct: 459 Q---NHQFELKKLKEEWSQ 474
Score = 42.0 bits (97), Expect = 0.003
Identities = 53/266 (19%), Positives = 114/266 (42%), Gaps = 17/266 (6%)
Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEA----DLAEQQHLRQQA 426
++K+ ++ L +++S ++ E + V+ L+ V+ LE +L+ ++H+ Q+
Sbjct: 262 EQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHV-QEL 320
Query: 427 ADDCEFLRAELDELRRQ----REDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSEL 478
+ L++ R+Q R KA +L E+E+ QA+E++ + K +
Sbjct: 321 LKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKG----I 376
Query: 479 VQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538
V +++ A ++ S +Q + LE++ E +LE +R E
Sbjct: 377 VAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQG 436
Query: 539 KQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKEL 598
++L L+ + E S Q+ + E +R+ + A EE+ R+E
Sbjct: 437 MRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEF 496
Query: 599 QDTQLKLASTEESMCQLAKDQRKMLL 624
Q L + + Q +++ ++LL
Sbjct: 497 QQQAANLTAIIDEKEQNLREKTEVLL 522
Score = 35.4 bits (80), Expect = 0.28
Identities = 40/201 (19%), Positives = 83/201 (41%), Gaps = 41/201 (20%)
Query: 382 REISGLKAQLENMKTE-SQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDEL 440
R + + +L+ +K E SQR ++ + LE +++ +QQAA+ + + L
Sbjct: 456 RSLQNHQFELKKLKEEWSQREIVSV-AMAQALEEVRKQREEFQQQAANLTAIIDEKEQNL 514
Query: 441 RRQREDTEKAQRSLSEIER----------KAQANEQRYSKLKEKYSELVQNHADLLRKNA 490
R + E + ++ + ++ER + QA + LK + + +V DLLR
Sbjct: 515 REKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRG 574
Query: 491 EVTKQVSMARQAQV-----------------------------DLEREKKELEDSLERIS 521
+ + ++ V L++EK++LE L +
Sbjct: 575 PLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKN 634
Query: 522 DQGQRKTQEQLEVLESLKQEL 542
++ Q LE+ ++L++EL
Sbjct: 635 KTIKQMQQRMLELRKTLQKEL 655
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 68.6 bits (166), Expect = 3e-11
Identities = 140/688 (20%), Positives = 277/688 (40%), Gaps = 89/688 (12%)
Query: 383 EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQ----QHLRQQAADDCEFLRAELD 438
E ++ LE + + L+ ++ A+L EQ Q ++Q+ + + ELD
Sbjct: 1170 EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD 1229
Query: 439 ELRRQREDTEKAQRSLSEIER--KAQANEQRYSKLKE---KYSELVQNHADLLRKNAEVT 493
++ E KA+ +L ++ R + Q NE R SK +E ++L A L +N E++
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHR-SKAEETQRSVNDLTSQRAKLQTENGELS 1288
Query: 494 KQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQ 553
+Q+ L R K LE + +R+ +E+++ +L L +++ + +L+
Sbjct: 1289 RQLDEKEALISQLTRGKLTYTQQLEDL----KRQLEEEVKAKNALAHALQSARHDCDLLR 1344
Query: 554 GSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHREEELSALRKELQDTQLKLASTE 609
E +++A ++ E R + A R EEL +K+L +L E
Sbjct: 1345 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ---RLQEAE 1401
Query: 610 ESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSI-SSCI 668
E++ A + + L ++ + I+D + +E + A + D I +
Sbjct: 1402 EAV--EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN--AAAAALDKKQRNFDKILAEWK 1457
Query: 669 EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH----------------GATTCLR 712
++ E+S S+ + ++ L + L + +++ H T L
Sbjct: 1458 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517
Query: 713 APPEPADSLTEACKQYGRETLAYLASLEE-EGSLENADSTAMRNCL--SKIKA-IGEELL 768
+ + L + KQ E + ++LEE E SLE+ + +R L ++IKA I +L
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1577
Query: 769 PRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTG---VKLEVNERILG 825
+ +++Q + L + TS ET + + K GD ++L R+
Sbjct: 1578 EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAA 1637
Query: 826 CCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATV 885
++++Q L+ KD Q ++ ++ R KE A R L+ A
Sbjct: 1638 EAQKQVKSLQSLL---KDTQIQLDDAVRANDDLKENIAIVER-RNNLLQAELEELRAVVE 1693
Query: 886 MVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQ--------Q 937
+ + + + +EL+ S + +Q + K D+ +L+QLQ +
Sbjct: 1694 QTERSRKLAE-----QELIETSERVQLLHSQNTSLINQKKKMDA-DLSQLQTEVEEAVQE 1747
Query: 938 ASRGVNQATAGVVASTISGKSQIEETD----------NMDFS------------SMTLTQ 975
+A + + + + +E D NM+ + + L
Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1807
Query: 976 IKRQEMDSQVRVLELENELQKERQKLGE 1003
K+Q + RV ELENEL+ E+++ E
Sbjct: 1808 GKKQLQKLEARVRELENELEAEQKRNAE 1835
Score = 61.6 bits (148), Expect = 4e-09
Identities = 104/509 (20%), Positives = 214/509 (42%), Gaps = 68/509 (13%)
Query: 370 KDEKDHLIERLYR---EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLR 423
+++K L ERL + E++ L A++E+ + ++ Q+ + +L+ + ELE +L ++ R
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129
Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483
+ L EL+E+ + E+ A E+ +K +A Q+ + E+ + + A
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1189
Query: 484 DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR--KTQEQLE-VL 535
LRK AE+ +Q+ ++ + LE+EK E + L+ ++ ++ K + LE +
Sbjct: 1190 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMC 1249
Query: 536 ESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEK---ERDSLVS----GAAHRE 588
+L+ ++ + + + Q S+ A E EL + E+++L+S G
Sbjct: 1250 RTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT 1309
Query: 589 EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLI 648
++L L+++L++ ++K + Q A+ +L EQ ++ + E ++
Sbjct: 1310 QQLEDLKRQLEE-EVKAKNALAHALQSARHDCDLL-------REQYEEETEAKAELQRVL 1361
Query: 649 SCAGSADHLLSTVTSISSC-----IEQLEKSWSQYLACPED----ISGLLHSITLLAHLT 699
S A S T + +E+ +K +Q L E+ ++ S+ H
Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRL 1421
Query: 700 SDAI---------AHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEG------- 743
+ I ++ A L D + KQ E+ + L S ++E
Sbjct: 1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481
Query: 744 -SLENADSTAM----------RNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSA 792
L+NA ++ +N +I + E+L G I + E V K++ A
Sbjct: 1482 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE---KVRKQLEAEKM 1538
Query: 793 AIETATARIEEMLSKSRAGDTGVKLEVNE 821
+++A E L +LE N+
Sbjct: 1539 ELQSALEEAEASLEHEEGKILRAQLEFNQ 1567
Score = 60.8 bits (146), Expect = 6e-09
Identities = 121/565 (21%), Positives = 232/565 (41%), Gaps = 72/565 (12%)
Query: 240 VKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFL 299
+KL FK+ L + + E+FT+LK+ +S + + L E L
Sbjct: 830 MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL 889
Query: 300 RASALSEHISPVV---------VIPAEASSPDSEPVLEKDDLM--DMDASQQNLFD---- 344
+ A ++++ I EA + LE ++ M ++ A ++ L D
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 949
Query: 345 --NKFDDIFGSSFSSDPFNFNSQNGV-NKDEK----DHLIERLYREISGL----KAQLEN 393
DD+ + + ++N V N E+ D +I +L +E L + L++
Sbjct: 950 LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1009
Query: 394 MKTESQRV------VLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDT 447
++ E +V ++L+ V +LE L +++ +R L +L + D
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069
Query: 448 EKAQRSLSEIERK----AQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ 503
E ++ L E +K A R + S+L + +L + E+ +++ R A+
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129
Query: 504 VDLEREKKELEDSLERISDQGQR---KTQEQLEVLESLKQELATSQRELQVLQGSLE--- 557
+E+ + +L LE IS++ + T Q+E+ + + E +R+L+ + +L+
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE--EATLQHEA 1187
Query: 558 TSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ------LKLASTEES 611
T+A A AEL ++ D+L E+E S + EL D +K + E
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK 1247
Query: 612 MCQLAKDQRKMLLVGSRKAAEQVIQDALNQL--EEPPLISCAGSADHLLSTVTSISSCIE 669
MC+ +DQ + ++ + Q ++N L + L + G L ++ S +
Sbjct: 1248 MCRTLEDQ-----MNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1302
Query: 670 QLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYG 729
+ + +++Q L ED+ L +A+AH L++ D L E QY
Sbjct: 1303 RGKLTYTQQL---EDLKRQLEEEV----KAKNALAH----ALQSARHDCDLLRE---QYE 1348
Query: 730 RETLAYLASLEEEGSLENADSTAMR 754
ET A A L+ S N++ R
Sbjct: 1349 EETEA-KAELQRVLSKANSEVAQWR 1372
Score = 56.6 bits (135), Expect = 1e-07
Identities = 114/594 (19%), Positives = 237/594 (39%), Gaps = 89/594 (14%)
Query: 460 KAQANEQRYSKLKEKYSELVQ--NHADLLRKNAEVTKQVSMARQ---AQVDLEREKKELE 514
K+ E+ + +KE+++ L + ++ RK E K VS+ ++ Q+ ++ E+ L
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELE-EKMVSLLQEKNDLQLQVQAEQDNLA 899
Query: 515 DSLERISDQGQRKTQ---------EQLEVLESLKQELATSQRELQVLQGSLETSAQSEAN 565
D+ ER + K Q E+LE E + EL +R+L+
Sbjct: 900 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE--------------- 944
Query: 566 WAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLV 625
E +EL+++ D L A E+E A ++++ ++A +E + +L K+
Sbjct: 945 --DECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE------- 995
Query: 626 GSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685
+KA ++ Q AL+ L+ + L + ++ LE S Q D+
Sbjct: 996 --KKALQEAHQQALDDLQAE-----EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDL 1048
Query: 686 SGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745
+ LT ++I L E K+ E A A +E+E +L
Sbjct: 1049 ERAKRKLEGDLKLTQESIMD--------LENDKQQLDERLKKKDFELNALNARIEDEQAL 1100
Query: 746 ENADSTAMRNCLSKIKAIGEEL-LPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804
+ ++ ++I+ + EEL R K E+L + +E+ S +E A
Sbjct: 1101 GSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA------- 1153
Query: 805 LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864
G T V++E+N++ + Q ++ +DL+ ++ A+ ++ +A
Sbjct: 1154 -----GGATSVQIEMNKK----REAEFQKMR------RDLEEATLQHEATAAALRKKHA- 1197
Query: 865 NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924
+ + + + V + + + +++ +I + A L +
Sbjct: 1198 -----DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252
Query: 925 ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIK---RQEM 981
D+ + + ++ ++ R VN T+ + D + LT+ K Q++
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 982 DSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTE 1035
+ R +LE E++ + L+ ++ + E +EE TEA LQ V+++
Sbjct: 1313 EDLKR--QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAK-AELQRVLSK 1363
Score = 55.5 bits (132), Expect = 3e-07
Identities = 127/695 (18%), Positives = 265/695 (38%), Gaps = 84/695 (12%)
Query: 387 LKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRED 446
++A+ +N+ +R +K + +LEA + E + +D E + AEL +R+ ED
Sbjct: 891 VQAEQDNLADAEERCDQLIKNKI-QLEAKVKEMN----ERLEDEEEMNAELTAKKRKLED 945
Query: 447 T-EKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVD 505
+ +R + ++E E+ + K L + A L A++TK+ ++A
Sbjct: 946 ECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1005
Query: 506 LEREKKELEDSLERISDQGQRKTQEQLEVLE-SLKQELATS---QRELQVLQGSLETSAQ 561
+ + ED + ++ + + K ++Q++ LE SL+QE +R + L+G L+ + +
Sbjct: 1006 ALDDLQAEEDKVNTLT-KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 562 SEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRK 621
S +LE ++ L ++ EL+AL ++D Q + ++ + +L Q +
Sbjct: 1065 S-------IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL---QAR 1114
Query: 622 MLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681
+ + AE+ + + +L ++ L + S IE +K +++
Sbjct: 1115 IEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKM 1174
Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741
D L TL T+ A+ + E D+L ++ +E + L++
Sbjct: 1175 RRD----LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD 1230
Query: 742 EGSLENADSTAMRNCLSKIKAIGEEL------------------------------LPRG 771
S A N + + +++ L R
Sbjct: 1231 VTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ 1290
Query: 772 LDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLM 831
LD K+ + L ++ T +E ++EE + A ++ ++ C L
Sbjct: 1291 LDEKEALISQLTRGKLTYTQ-QLEDLKRQLEEEVKAKNALAHALQSARHD-----CDLLR 1344
Query: 832 QAIQVLIVASKDLQREIVESGRGTASPKEFYAKNS-RWTEGLISASKAVGWGATVMVDAA 890
+ + A +LQR + ++ A + Y ++ + TE L A K + A + +A
Sbjct: 1345 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL---AQRLQEAE 1401
Query: 891 DLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVV 950
+ V K L H + L+ V ++ + A L + R ++ A
Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLM----VDVERSNAAAAALDKKQRNFDKILAEWK 1457
Query: 951 ASTISGKSQIEETDNMDFSSMT---------------LTQIKRQEMDSQVRVLELENELQ 995
+S++E + S T L KR+ + Q + +L +L
Sbjct: 1458 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517
Query: 996 KERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQ 1030
+ + EL K +L + E + +L+
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLE 1552
Score = 46.2 bits (108), Expect = 2e-04
Identities = 117/663 (17%), Positives = 264/663 (39%), Gaps = 67/663 (10%)
Query: 397 ESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSE 456
E ++ + +K + L+ L + + R++ + L E ++L+ Q + Q +L++
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQ---VQAEQDNLAD 900
Query: 457 IERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDS 516
E + + +L+ K E+ + D NAE+T + +L+R+ +LE +
Sbjct: 901 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELT 960
Query: 517 LERISDQ---GQRKTQEQLEVLESLKQELATSQRELQVLQGSLETS---AQSEANWAAEF 570
L ++ + + K + E + L + +A +E + LQ + + + Q+E +
Sbjct: 961 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1020
Query: 571 AELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS----TEESMCQLAKDQRKMLLVG 626
+ + + + V E+ +R +L+ + KL T+ES+ L D++++
Sbjct: 1021 TKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL---D 1077
Query: 627 SRKAAEQVIQDALN-QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685
R + +ALN ++E+ + L + + + IE+LE+ +
Sbjct: 1078 ERLKKKDFELNALNARIEDEQAL-----GSQLQKKLKELQARIEELEEELEAERTARAKV 1132
Query: 686 SGLLHSITLLAHLTSDAI--AHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEG 743
L ++ S+ + A GAT+ + ++ + ++ E A+L+ E
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE-----ATLQHEA 1187
Query: 744 SL-----ENADSTA-MRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KEMAATSAAIE 795
+ ++ADS A + + ++ + ++L + K EL D+ +++ A +E
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL-ELDDVTSNMEQIIKAKANLE 1246
Query: 796 TATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES---- 851
+E+ +++ R+ K E +R + TS +Q + +L R++ E
Sbjct: 1247 KMCRTLEDQMNEHRS-----KAEETQRSVNDLTSQRAKLQ---TENGELSRQLDEKEALI 1298
Query: 852 ---GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSH 908
RG + + R E + A A+ DL+ + + E
Sbjct: 1299 SQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1358
Query: 909 EIAASTAQLVAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMD 967
+ + VA + K + D+ +L++A + +A + + E N
Sbjct: 1359 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQEAEEAVEAVNAK 1410
Query: 968 FSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPP 1027
SS+ T+ + Q + +L ++++ L KK + W++ E S
Sbjct: 1411 CSSLEKTKHRLQN-----EIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465
Query: 1028 TLQ 1030
L+
Sbjct: 1466 ELE 1468
Score = 39.3 bits (90), Expect = 0.019
Identities = 68/324 (20%), Positives = 128/324 (39%), Gaps = 70/324 (21%)
Query: 369 NKDEKDHLIERLYREISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425
+++E + +++ +++ ++ QL + M E+Q+ V L+ + + + L +
Sbjct: 1607 SRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD 1666
Query: 426 AADDC-------EFLRAELDELRRQREDTEK----AQRSLSEIERKAQANEQRYSKLKEK 474
++ L+AEL+ELR E TE+ A++ L E + Q + + L +
Sbjct: 1667 LKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1726
Query: 475 YSELVQNHADLLRKNAEVTKQVSMARQAQ------------------------VDLEREK 510
++ ADL + EV + V R A+ LER K
Sbjct: 1727 KKKM---DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1783
Query: 511 KELE----------DSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSA 560
K +E D E+I+ +G +K QL+ LE+ +E L+ LE
Sbjct: 1784 KNMEQTIKDLQHRLDEAEQIALKGGKK---QLQKLEARVRE----------LENELEAEQ 1830
Query: 561 QSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQR 620
+ A + E+ L + L L+ + QLK+ + + + A++Q
Sbjct: 1831 KRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKR-QAEEAEEQA 1889
Query: 621 KMLLVGSRKAAEQVIQDALNQLEE 644
L RK +Q L++ EE
Sbjct: 1890 NTNLSKFRK-----VQHELDEAEE 1908
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.352
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,456,158
Number of Sequences: 37866
Number of extensions: 1530778
Number of successful extensions: 14042
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 352
Number of HSP's successfully gapped in prelim test: 954
Number of HSP's that attempted gapping in prelim test: 6201
Number of HSP's gapped (non-prelim): 4844
length of query: 1037
length of database: 18,247,518
effective HSP length: 112
effective length of query: 925
effective length of database: 14,006,526
effective search space: 12956036550
effective search space used: 12956036550
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.