BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|38045919 huntingtin interacting protein 1 [Homo sapiens] (1037 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|38045919 huntingtin interacting protein 1 [Homo sapiens] 2019 0.0 gi|48762942 huntingtin interacting protein-1-related [Homo sapiens] 984 0.0 gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens] 842 0.0 gi|156938343 talin 2 [Homo sapiens] 130 6e-30 gi|223029410 talin 1 [Homo sapiens] 127 5e-29 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 77 6e-14 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 77 6e-14 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 77 6e-14 gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 77 6e-14 gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 75 3e-13 gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 75 3e-13 gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 75 3e-13 gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 75 3e-13 gi|42794779 myosin 18A isoform b [Homo sapiens] 75 3e-13 gi|28416946 myosin 18A isoform a [Homo sapiens] 75 3e-13 gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 75 3e-13 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 74 7e-13 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 74 9e-13 gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 73 2e-12 gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 72 2e-12 gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 72 3e-12 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 71 5e-12 gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 71 5e-12 gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 71 5e-12 gi|31982906 cingulin-like 1 [Homo sapiens] 71 6e-12 gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 70 8e-12 gi|16262452 cingulin [Homo sapiens] 70 1e-11 gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens] 69 2e-11 gi|4504063 golgin 97 [Homo sapiens] 69 2e-11 gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 69 3e-11 >gi|38045919 huntingtin interacting protein 1 [Homo sapiens] Length = 1037 Score = 2019 bits (5231), Expect = 0.0 Identities = 1037/1037 (100%), Positives = 1037/1037 (100%) Query: 1 MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHA 60 MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHA Sbjct: 1 MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHA 60 Query: 61 RTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNE 120 RTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNE Sbjct: 61 RTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNE 120 Query: 121 LSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN 180 LSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN Sbjct: 121 LSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN 180 Query: 181 FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTV 240 FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTV Sbjct: 181 FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTV 240 Query: 241 KLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLR 300 KLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLR Sbjct: 241 KLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLR 300 Query: 301 ASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF 360 ASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF Sbjct: 301 ASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF 360 Query: 361 NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQ 420 NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQ Sbjct: 361 NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQ 420 Query: 421 HLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480 HLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ Sbjct: 421 HLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480 Query: 481 NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ 540 NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ Sbjct: 481 NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ 540 Query: 541 ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD 600 ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD Sbjct: 541 ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD 600 Query: 601 TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLST 660 TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLST Sbjct: 601 TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLST 660 Query: 661 VTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS 720 VTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS Sbjct: 661 VTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS 720 Query: 721 LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG 780 LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG Sbjct: 721 LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG 780 Query: 781 DLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA 840 DLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA Sbjct: 781 DLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA 840 Query: 841 SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF 900 SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF Sbjct: 841 SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF 900 Query: 901 EELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQI 960 EELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQI Sbjct: 901 EELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQI 960 Query: 961 EETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE 1020 EETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE Sbjct: 961 EETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE 1020 Query: 1021 GTEASPPTLQEVVTEKE 1037 GTEASPPTLQEVVTEKE Sbjct: 1021 GTEASPPTLQEVVTEKE 1037 >gi|48762942 huntingtin interacting protein-1-related [Homo sapiens] Length = 1068 Score = 984 bits (2545), Expect = 0.0 Identities = 529/1055 (50%), Positives = 719/1055 (68%), Gaps = 43/1055 (4%) Query: 8 MKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGT 67 M + N +VLSRR G LEA ERE F++TQ +SI+KAINTQE VKEKHAR ILGT Sbjct: 1 MNSIKNVPARVLSRRP-GHSLEA-EREQFDKTQAISISKAINTQEAPVKEKHARRIILGT 58 Query: 68 HHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRM 127 HHEKGA TFWS LPL S+++L WKFCHV HK+LRDGHPNVL D RYR+ + ++ + Sbjct: 59 HHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDL 118 Query: 128 WGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVE 187 WGHL + YGQL ++Y KLL TK+ +H K+P+FP L+++D L++A +DVNN FQLTVE Sbjct: 119 WGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVE 178 Query: 188 MFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLH 247 MFDY++CEL L ++VF L+ + +VS ++GQCRLAPLIQVI DCSHLY YTVKLLFKLH Sbjct: 179 MFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLH 238 Query: 248 SCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEH 307 SCLPADTLQGHRDRF EQF L++ F R+S++ YFKRLIQIP+LPE PPNFLRASAL+EH Sbjct: 239 SCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEH 298 Query: 308 ISPVVVIPAEASSPDSEPVLEKDDLMDMD----ASQQNLFDNKFDDIFGSSFSSDPFNFN 363 I PVVVIP EA P+ E E ++L+++ A + + + FD FG Sbjct: 299 IKPVVVIPEEA--PEDE---EPENLIEISTGPPAGEPVVVADLFDQTFGPP--------- 344 Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLR 423 NG KD++D IE L RE+ L+++LE +K E+QR + QLK V+ LE +L EQ+ + Sbjct: 345 --NGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQK 402 Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483 Q+A D E LR EL +LR + + E++Q E ERKA A E RY+KLKEK+SELV HA Sbjct: 403 QKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 462 Query: 484 DLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELA 543 +LLRKNA+ KQ+++ +Q+Q ++ R K++L +E++ + + K +E+ + LE LK+EL Sbjct: 463 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE 522 Query: 544 TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603 EL Q +L + QS++ ++ L E+D+L RE +L A + +++T+ Sbjct: 523 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582 Query: 604 KLA---------------------STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQL 642 L+ S E+ + Q D++ +L G+ A ++QDA+++L Sbjct: 583 ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKL 642 Query: 643 EEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDA 702 ++P + C S D+L+S + LE+ +QYL D S L+ ++T +HL +D Sbjct: 643 DDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADT 702 Query: 703 IAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKA 762 I +G T AP +PAD L + C++ G L + L+++ +L + ++ +R L I Sbjct: 703 IINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQ 762 Query: 763 IGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNER 822 +G+EL P+ LD++QEELG +VDKEMAATSAAIE A RIE+M++++R +GVKLEVNER Sbjct: 763 LGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER 822 Query: 823 ILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWG 882 IL CT LM+AI++L+ S LQ+EIVESGRG A+ +EFYAKNSRWTEGLISASKAVGWG Sbjct: 823 ILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWG 882 Query: 883 ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGV 942 AT +V+AAD VV GK+EEL+VCSHEIAASTAQLVAASKVKA+K SP+L++LQ+ SR V Sbjct: 883 ATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTV 942 Query: 943 NQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLG 1002 N+ A VVAST SG+ QIE+ D MDFS ++L ++K+QEM++QVRVLELE L+ ER +LG Sbjct: 943 NERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLG 1002 Query: 1003 ELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037 ELRK+HY LAG + E P T VT K+ Sbjct: 1003 ELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1037 >gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens] Length = 1048 Score = 842 bits (2176), Expect = 0.0 Identities = 477/1035 (46%), Positives = 660/1035 (63%), Gaps = 68/1035 (6%) Query: 40 QTVSINKAINTQEVAVKEKHARTCILGTH----HEKGAQTFW-----SVVNRLPLSSNAV 90 + V+ + + + A +E CIL TH G W S V +P A Sbjct: 14 EPVAGRRFLGSPRPAAEESGLEVCILSTHTVRPESPGGPAIWMHCKTSGVRDVPGGQRA- 72 Query: 91 LCW---KFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLR 147 L W + C V L RD D GHL + YGQL ++Y KLL Sbjct: 73 LAWFSLEHCGVLVCLGRDIGAGQALDR--------------GHLHDRYGQLVNVYTKLLL 118 Query: 148 TKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLD 207 TK+ +H K+P+FP L+++D L++A +DVNN FQLTVEMFDY++CEL L ++VF L+ Sbjct: 119 TKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLN 178 Query: 208 MSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFT 267 + +VS ++GQCRLAPLIQVI DCSHLY YTVKLLFKLHSCLPADTLQGHRDRF EQF Sbjct: 179 TAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFH 238 Query: 268 KLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVL 327 L++ F R+S++ YFKRLIQIP+LPE PPNFLRASAL+EHI PVVVIP EA P+ E Sbjct: 239 SLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEA--PEDE--- 293 Query: 328 EKDDLMDMD----ASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYRE 383 E ++L+++ A + + + FD FG NG KD++D IE L RE Sbjct: 294 EPENLIEISTGPPAGEPVVVADLFDQTFGPP-----------NGSVKDDRDLQIESLKRE 342 Query: 384 ISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQ 443 + L+++LE +K E+QR + QLK V+ LE +L EQ+ +Q+A D E LR EL +LR Sbjct: 343 VEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAA 402 Query: 444 REDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ 503 + + E++Q E ERKA A E RY+KLKEK+SELV HA+LLRKNA+ KQ+++ +Q+Q Sbjct: 403 QLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQ 462 Query: 504 VDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSE 563 ++ R K++L +E++ + + K +E+ + LE LK+EL EL Q +L + QS+ Sbjct: 463 EEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSK 522 Query: 564 ANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLA----------------- 606 + ++ L E+D+L RE +L A + +++T+ L+ Sbjct: 523 SELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 582 Query: 607 ----STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVT 662 S E+ + Q D++ +L G+ A ++QDA+++L++P + C S D+L+S Sbjct: 583 AERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQ 642 Query: 663 SISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLT 722 + LE+ +QYL D S L+ ++T +HL +D I +G T AP +PAD L Sbjct: 643 EALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI 702 Query: 723 EACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL 782 + C++ G L + L+++ +L + ++ +R L I +G+EL P+ LD++QEELG + Sbjct: 703 DTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAV 762 Query: 783 VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK 842 VDKEMAATSAAIE A RIE+M++++R +GVKLEVNERIL CT LM+AI++L+ S Sbjct: 763 VDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTST 822 Query: 843 DLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEE 902 LQ+EIVESGRG A+ +EFYAKNSRWTEGLISASKAVGWGAT +V+AAD VV GK+EE Sbjct: 823 SLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEE 882 Query: 903 LMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962 L+VCSHEIAASTAQLVAASKVKA+K SP+L++LQ+ SR VN+ A VVAST SG+ QIE+ Sbjct: 883 LIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIED 942 Query: 963 TDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022 D MDFS ++L ++K+QEM++QVRVLELE L+ ER +LGELRK+HY LAG + E Sbjct: 943 RDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEV 1002 Query: 1023 EASPPTLQEVVTEKE 1037 P T VT K+ Sbjct: 1003 AIRPSTAPRSVTTKK 1017 >gi|156938343 talin 2 [Homo sapiens] Length = 2542 Score = 130 bits (327), Expect = 6e-30 Identities = 124/534 (23%), Positives = 239/534 (44%), Gaps = 71/534 (13%) Query: 557 ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEE-SMCQL 615 ET A N L ++ LVSGAA ++L+ + T +LA + L Sbjct: 2011 ETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASL 2070 Query: 616 AKD--QRKMLLVGSRKAAEQVIQDALNQ--------LEEPPLISCAGSADHLLSTVTSIS 665 D + +++L+ + K + + D ++ +++P + G+A +++ VTS+ Sbjct: 2071 GSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLL 2130 Query: 666 SCIEQLE--------------------------KSWSQYLACPEDISGLLHSITLL---- 695 ++ +E K + + PE+ + IT+ Sbjct: 2131 KTVKAVEDEATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKA 2190 Query: 696 ---------------AHLTSDAIAHGATTCLRAP--PEPADSLTEACKQYGRE-TLAYLA 737 A+L+ A++ T C +A P+ +D + ++G E TL YL Sbjct: 2191 VAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPDVSDEVRTRALRFGTECTLGYLD 2250 Query: 738 SLEEEGSLENADSTAMRNCLS----KIKAIGEELLPRGLDIKQEELGD------LVDKEM 787 LE + + + L+ ++ EL+ +K E D + + E+ Sbjct: 2251 LLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETEL 2310 Query: 788 AATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQRE 847 +A+IE A ++E++ +++ L+ E+IL S+ A L+ ++ QRE Sbjct: 2311 LGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRE 2370 Query: 848 IVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCS 907 +V G+ + P A + +W++GLISA++ V + + +AA+ VQG E+L+ + Sbjct: 2371 LVAQGKVGSIPANA-ADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISSA 2429 Query: 908 HEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMD 967 ++AASTAQL+ A KVKAD+DS + +LQ A V +A+ +V + + D++ Sbjct: 2430 KQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVV 2489 Query: 968 FSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEG 1021 + + I Q + +Q +L+ E EL++ R+KL ++R++ Y+ +EG Sbjct: 2490 VKTKFVGGI-AQIIAAQEEMLKKERELEEARKKLAQIRQQQYKFLPTELREDEG 2542 Score = 38.9 bits (89), Expect = 0.025 Identities = 51/194 (26%), Positives = 78/194 (40%), Gaps = 48/194 (24%) Query: 780 GDLVDKEMAATSAAIETATARIEEM---------LSKSRAGDTGVKLEVNERILGCCTSL 830 GD D + A AI T ++ + EM L G L + G + L Sbjct: 566 GDPADTDYTAVGCAITTISSNLTEMSKGVKLLAALMDDEVGSGEDLLRAARTLAGAVSDL 625 Query: 831 MQAIQ---------VLIVA------SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISA 875 ++A+Q VL A S DL R+I E+ + R+ + L+S Sbjct: 626 LKAVQPTSGEPRQTVLTAAGSIGQASGDLLRQIGEN-----------ETDERFQDVLMSL 674 Query: 876 SKAVGWGATVMV--------DAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADK 927 +KAV A ++V A D V+Q R ++ + + A ST+QLVA +KV + Sbjct: 675 AKAVANAAAMLVLKAKNVAQVAEDTVLQNR-----VIAAATQCALSTSQLVACAKVVSPT 729 Query: 928 DSPNLAQLQQASRG 941 S + Q Q G Sbjct: 730 ISSPVCQEQLIEAG 743 >gi|223029410 talin 1 [Homo sapiens] Length = 2541 Score = 127 bits (319), Expect = 5e-29 Identities = 156/641 (24%), Positives = 260/641 (40%), Gaps = 106/641 (16%) Query: 461 AQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERI 520 A NE+ S +K + EL A L+ K A Q KKEL + R+ Sbjct: 1906 AAENEEIGSHIKHRVQELGHGCAALVTKAG--------ALQCSPSDAYTKKELIECARRV 1957 Query: 521 SDQ----------GQRKTQEQLEVLESLKQELATSQRELQ-VLQGSL-----ETSAQSEA 564 S++ G R TQ + ++ +A + G+L ET A Sbjct: 1958 SEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHRE 2017 Query: 565 NWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS---------------TE 609 L ++ LV AA +E+L+ + T +LA T+ Sbjct: 2018 GILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQ 2077 Query: 610 ESMCQLAKDQRKML--LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSC 667 + KD K L L+ + KAA + D +P + SA +++ VTS+ Sbjct: 2078 VVLINAVKDVAKALGDLISATKAAAGKVGD------DPAVWQLKNSAKVMVTNVTSLLKT 2131 Query: 668 IEQLEKSWS--------------QYLAC------------PEDISGLLHSITLL------ 695 ++ +E + Q LA PED + IT+ Sbjct: 2132 VKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVA 2191 Query: 696 -------------AHLTSDAIAHGATTCLRAP--PEPADSLTEACKQYGRETL-AYLASL 739 A+L+ AIA C A PE A + YGRE YL L Sbjct: 2192 AGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELL 2251 Query: 740 EEEGSLENADSTAMRNCLS----KIKAIGEELLPRGLDIKQEELGD------LVDKEMAA 789 + S ++ L+ ++ EL+ +K E D + + E+ Sbjct: 2252 DHVLLTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLG 2311 Query: 790 TSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIV 849 +AAIE A ++E++ +++ + L E+IL S+ A L+ A+ QRE+V Sbjct: 2312 AAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELV 2371 Query: 850 ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHE 909 G+ A P + +W++GLISA++ V + +AA+ VQG E+L+ + + Sbjct: 2372 AQGKVGAIPANAL-DDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQ 2430 Query: 910 IAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFS 969 +AASTAQL+ A KVKAD+DS + +LQ A V +A+ +V + + E+ + Sbjct: 2431 VAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVV 2490 Query: 970 SMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010 + Q + +Q +L E EL++ R+KL ++R++ Y+ Sbjct: 2491 KEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYK 2531 Score = 40.0 bits (92), Expect = 0.011 Identities = 47/195 (24%), Positives = 88/195 (45%), Gaps = 24/195 (12%) Query: 780 GDLVDKEMAATSAAIETATARIEEM---------LSKSRAGDTGVKLEVNERILGCCTSL 830 GD + + A A+ T ++ + EM L + G L+ + + G + L Sbjct: 563 GDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSEL 622 Query: 831 MQAIQVLIVASKDLQREIVESGR--GTASPKEFYA-----KNSRWTEGLISASKAVGWGA 883 +++ Q AS + ++ ++++ G AS + + + + L+ +KAV A Sbjct: 623 LRSAQP---ASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALMQLAKAVASAA 679 Query: 884 TVMVDAADLVVQ---GRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLA--QLQQA 938 +V A V Q G +++ + + A ST+QLVA +KV A S + QL +A Sbjct: 680 AALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEA 739 Query: 939 SRGVNQATAGVVAST 953 R V +A G V+++ Sbjct: 740 GRLVAKAVEGCVSAS 754 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 77.4 bits (189), Expect = 6e-14 Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%) Query: 383 EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439 E+ A+L++ K + + + +L+GH+S+L+ DL ++ R +A L EL+ Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150 Query: 440 LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480 L+ + EDT + + E+ K + ++E + ++++K+++ V+ Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210 Query: 481 --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523 N L ++NA++ ++ + QA+ ++E +KK+LE ++ + + Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270 Query: 524 GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562 G+R K Q ++E + L +++A+ +LQ Q L+ + Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330 Query: 563 EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612 + N + + +LE+ER+SL + + E +S L +L D++ KL AST E++ Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390 Query: 613 CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664 + K +K + + AA ++ N+L++ D L L + Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1442 Query: 665 SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721 S +E+ ++ + Q LA ++IS A + + A L E + L Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502 Query: 722 TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769 K E ++S ++ G + A T M ++++ + +EL Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562 Query: 770 RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809 L++ + L ++++ A E +++ L K Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622 Query: 810 AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868 GD ++L+ + I G ++ Q ++ L KD QRE+ ++ AS E +A Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1677 Query: 869 TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928 + KA A +M DL R + ++ + E+A A ++ D+ Sbjct: 1678 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1731 Query: 929 SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988 A++ Q + + + A + + ++ + + + + + Q+ +S + L Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1790 Query: 989 ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036 E +N+ ELR K +E+ G + + T EA L+E V ++ Sbjct: 1791 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833 Score = 62.8 bits (151), Expect = 2e-09 Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%) Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436 + R E+ + +L+ K Q+ +LK + + + L E+++L Q+ L AE Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 905 Query: 437 LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495 +E+R R ++ + L E+E + + E R +L+ + ++ Q DL + E Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965 Query: 496 VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555 + +V E + K+LED + + DQ + ++E+ ++LE +L T+ E + + Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1024 Query: 556 LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604 L + +E ELEK + L A+ E+++ L+ ++ + +++ Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084 Query: 605 LASTEESM 612 LA EE + Sbjct: 1085 LAKKEEEL 1092 Score = 60.5 bits (145), Expect = 8e-09 Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%) Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490 E ++A+ DEL++ +E +KA+ L E+E+K + ++ K E +Q +L + Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 907 Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537 E+ +++ +Q +LE E+E LE D+GQ+ +EQLE E+ Sbjct: 908 EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964 Query: 538 LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593 +Q+L T++ +++ L+ + + E LE+ L + A EE+ Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024 Query: 594 LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646 L K + + +++L E+S +L K +RK L G + I D Q+ E Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1082 Query: 647 LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706 + A + L + + + I Q + + ++ G H L L S+ A Sbjct: 1083 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1135 Query: 707 ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766 +A + D G E A LE + DSTA + L + Sbjct: 1136 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1177 Query: 767 LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824 +L + LD + V + + A+E T ++E+ +K+ LE N + Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237 Query: 825 GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884 G L QA Q + K L+ ++ E + + A+ + L + ++V T Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1293 Query: 885 VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944 M++ A+ GK +L + ++A+ ++QL +D+ L Q ++ + +N Sbjct: 1294 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1334 Query: 945 ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004 +T Q+EE N +L +EM+++ LE + +L + Sbjct: 1335 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1376 Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037 +KK + A E EEG + ++ + + E Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409 Score = 59.7 bits (143), Expect = 1e-08 Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%) Query: 324 EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381 + +L DD + + ++ L + + D+ + + N NK E L RL Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044 Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441 +E + +LE +K + + +++L+A +AE L+ Q A E L+A L L Sbjct: 1045 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1099 Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501 D E AQ++ K++E + DL + A K R Sbjct: 1100 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143 Query: 502 AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558 +LE K ELED+L+ + Q + + + + EV ++L +E + + ++Q ++ Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203 Query: 559 SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614 + + +F A L+K + +L A EL L + Q+ + K E + + Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263 Query: 615 LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668 L + G R AE + D +++L+ L G A L V S+SS + Sbjct: 1264 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317 Query: 669 EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728 + ++ LL T + +T LR E +SL + Sbjct: 1318 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1353 Query: 729 GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786 E + +LE S N + + L A E L G Q+E+ +L +E Sbjct: 1354 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1410 Query: 787 MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846 AA +E R+++ L D V L+ +++ + L+ K++ Sbjct: 1411 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465 Query: 847 EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905 + E R A +E K +S ++A+ + + + E+L+ Sbjct: 1466 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518 Query: 906 CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962 ++ + +L A + + ++ L +L+ + A + + + K Q E Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578 Query: 963 TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010 D + + KR+++ Q+ E E E +++++ L KK E Sbjct: 1579 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623 Score = 56.2 bits (134), Expect = 2e-07 Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%) Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434 R++ + L++ E L+ H+S L L++ + Q A E L + Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398 Query: 435 AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480 E++ L +Q E+ A L + + + Q + QR K + K+ +L+ Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458 Query: 481 NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518 ++ K A+ TK +S+AR +A+ +LER K E+ED + Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518 Query: 519 RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575 D G+ + ++ LE+ +E+ T EL+ LQ + + + E N A + E+ Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578 Query: 576 ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633 + L + EE+ L+++L +T+L+ + ++ AK + + L A+ Sbjct: 1579 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635 Query: 634 VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681 I ++A+ QL + L S D + +T + LE + + Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1692 Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741 ED++ A L + +A + L S A + R A +A LEE Sbjct: 1693 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1743 Query: 742 EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778 E E + AM + + K E+L + L K E Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803 Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSK 807 + V + +T AA+E A++EE + + Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832 Score = 55.5 bits (132), Expect = 3e-07 Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%) Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427 ++ + +L R++ + +LE+ + + +L+G + +LE R++A Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644 Query: 428 DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487 L+A++ + +R+ ED A+ S EI A+ NE++ L+ ADL++ Sbjct: 1645 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1691 Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547 ++ +QA ++ E +EL SL G+ Q++ LE+ +A + Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1743 Query: 548 ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607 EL+ QG++E + + +L E + S A E L ++ ++ + KL Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803 Query: 608 TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638 E ++ K L + EQV Q+A Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834 Score = 52.0 bits (123), Expect = 3e-06 Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%) Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429 K E + ++ + + + + + ++ E +++ Q+ +LE + A +Q L+ + Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976 Query: 430 CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489 ++ DE+ + K + ERK L+E+ S+L N A+ K Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1022 Query: 490 AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539 +T K SM + +V L++E+K + + L+R + EQ+ L++ LK Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082 Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588 +LA + ELQ L+ + N + ELE ++ L S A R Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142 Query: 589 ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644 EEL AL+ EL+DT A+ +E + +R+ + +KA ++ + Q++E Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1196 Score = 51.6 bits (122), Expect = 4e-06 Identities = 64/281 (22%), Positives = 121/281 (43%), Gaps = 40/281 (14%) Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431 EK+ L E L +SG A L++ K + + QL+ + E + ++ ++A E Sbjct: 1709 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767 Query: 432 FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487 L +EL +R +K + + ++ER+ N++ SKL E S+ A L Sbjct: 1768 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1821 Query: 488 KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELA 543 K A++ +QV AR+ Q L+++ K+L++ L ++ D+ RK EQ K++ Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE--RKMAEQY------KEQAE 1873 Query: 544 TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603 ++ L+ LE + + A +L++E D E++AL+ +L+ Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR---- 1929 Query: 604 KLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644 + + R +VI++A EE Sbjct: 1930 -------------RGNETSFVPSRRSGGRRVIENADGSEEE 1957 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 77.4 bits (189), Expect = 6e-14 Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%) Query: 383 EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439 E+ A+L++ K + + + +L+GH+S+L+ DL ++ R +A L EL+ Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157 Query: 440 LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480 L+ + EDT + + E+ K + ++E + ++++K+++ V+ Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217 Query: 481 --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523 N L ++NA++ ++ + QA+ ++E +KK+LE ++ + + Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277 Query: 524 GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562 G+R K Q ++E + L +++A+ +LQ Q L+ + Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337 Query: 563 EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612 + N + + +LE+ER+SL + + E +S L +L D++ KL AST E++ Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397 Query: 613 CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664 + K +K + + AA ++ N+L++ D L L + Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1449 Query: 665 SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721 S +E+ ++ + Q LA ++IS A + + A L E + L Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509 Query: 722 TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769 K E ++S ++ G + A T M ++++ + +EL Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569 Query: 770 RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809 L++ + L ++++ A E +++ L K Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629 Query: 810 AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868 GD ++L+ + I G ++ Q ++ L KD QRE+ ++ AS E +A Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1684 Query: 869 TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928 + KA A +M DL R + ++ + E+A A ++ D+ Sbjct: 1685 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1738 Query: 929 SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988 A++ Q + + + A + + ++ + + + + + Q+ +S + L Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1797 Query: 989 ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036 E +N+ ELR K +E+ G + + T EA L+E V ++ Sbjct: 1798 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840 Score = 62.8 bits (151), Expect = 2e-09 Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%) Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436 + R E+ + +L+ K Q+ +LK + + + L E+++L Q+ L AE Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 912 Query: 437 LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495 +E+R R ++ + L E+E + + E R +L+ + ++ Q DL + E Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972 Query: 496 VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555 + +V E + K+LED + + DQ + ++E+ ++LE +L T+ E + + Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1031 Query: 556 LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604 L + +E ELEK + L A+ E+++ L+ ++ + +++ Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091 Query: 605 LASTEESM 612 LA EE + Sbjct: 1092 LAKKEEEL 1099 Score = 60.5 bits (145), Expect = 8e-09 Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%) Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490 E ++A+ DEL++ +E +KA+ L E+E+K + ++ K E +Q +L + Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 914 Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537 E+ +++ +Q +LE E+E LE D+GQ+ +EQLE E+ Sbjct: 915 EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971 Query: 538 LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593 +Q+L T++ +++ L+ + + E LE+ L + A EE+ Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031 Query: 594 LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646 L K + + +++L E+S +L K +RK L G + I D Q+ E Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1089 Query: 647 LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706 + A + L + + + I Q + + ++ G H L L S+ A Sbjct: 1090 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1142 Query: 707 ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766 +A + D G E A LE + DSTA + L + Sbjct: 1143 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1184 Query: 767 LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824 +L + LD + V + + A+E T ++E+ +K+ LE N + Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244 Query: 825 GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884 G L QA Q + K L+ ++ E + + A+ + L + ++V T Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1300 Query: 885 VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944 M++ A+ GK +L + ++A+ ++QL +D+ L Q ++ + +N Sbjct: 1301 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1341 Query: 945 ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004 +T Q+EE N +L +EM+++ LE + +L + Sbjct: 1342 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1383 Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037 +KK + A E EEG + ++ + + E Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416 Score = 59.7 bits (143), Expect = 1e-08 Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%) Query: 324 EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381 + +L DD + + ++ L + + D+ + + N NK E L RL Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051 Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441 +E + +LE +K + + +++L+A +AE L+ Q A E L+A L L Sbjct: 1052 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1106 Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501 D E AQ++ K++E + DL + A K R Sbjct: 1107 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150 Query: 502 AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558 +LE K ELED+L+ + Q + + + + EV ++L +E + + ++Q ++ Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210 Query: 559 SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614 + + +F A L+K + +L A EL L + Q+ + K E + + Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270 Query: 615 LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668 L + G R AE + D +++L+ L G A L V S+SS + Sbjct: 1271 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324 Query: 669 EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728 + ++ LL T + +T LR E +SL + Sbjct: 1325 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1360 Query: 729 GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786 E + +LE S N + + L A E L G Q+E+ +L +E Sbjct: 1361 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1417 Query: 787 MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846 AA +E R+++ L D V L+ +++ + L+ K++ Sbjct: 1418 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472 Query: 847 EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905 + E R A +E K +S ++A+ + + + E+L+ Sbjct: 1473 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525 Query: 906 CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962 ++ + +L A + + ++ L +L+ + A + + + K Q E Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585 Query: 963 TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010 D + + KR+++ Q+ E E E +++++ L KK E Sbjct: 1586 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630 Score = 56.2 bits (134), Expect = 2e-07 Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%) Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434 R++ + L++ E L+ H+S L L++ + Q A E L + Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405 Query: 435 AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480 E++ L +Q E+ A L + + + Q + QR K + K+ +L+ Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465 Query: 481 NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518 ++ K A+ TK +S+AR +A+ +LER K E+ED + Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525 Query: 519 RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575 D G+ + ++ LE+ +E+ T EL+ LQ + + + E N A + E+ Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585 Query: 576 ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633 + L + EE+ L+++L +T+L+ + ++ AK + + L A+ Sbjct: 1586 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642 Query: 634 VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681 I ++A+ QL + L S D + +T + LE + + Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1699 Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741 ED++ A L + +A + L S A + R A +A LEE Sbjct: 1700 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1750 Query: 742 EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778 E E + AM + + K E+L + L K E Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810 Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSK 807 + V + +T AA+E A++EE + + Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839 Score = 55.5 bits (132), Expect = 3e-07 Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%) Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427 ++ + +L R++ + +LE+ + + +L+G + +LE R++A Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651 Query: 428 DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487 L+A++ + +R+ ED A+ S EI A+ NE++ L+ ADL++ Sbjct: 1652 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1698 Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547 ++ +QA ++ E +EL SL G+ Q++ LE+ +A + Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1750 Query: 548 ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607 EL+ QG++E + + +L E + S A E L ++ ++ + KL Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810 Query: 608 TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638 E ++ K L + EQV Q+A Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841 Score = 52.0 bits (123), Expect = 3e-06 Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%) Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429 K E + ++ + + + + + ++ E +++ Q+ +LE + A +Q L+ + Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983 Query: 430 CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489 ++ DE+ + K + ERK L+E+ S+L N A+ K Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1029 Query: 490 AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539 +T K SM + +V L++E+K + + L+R + EQ+ L++ LK Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089 Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588 +LA + ELQ L+ + N + ELE ++ L S A R Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149 Query: 589 ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644 EEL AL+ EL+DT A+ +E + +R+ + +KA ++ + Q++E Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1203 Score = 51.6 bits (122), Expect = 4e-06 Identities = 64/281 (22%), Positives = 121/281 (43%), Gaps = 40/281 (14%) Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431 EK+ L E L +SG A L++ K + + QL+ + E + ++ ++A E Sbjct: 1716 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774 Query: 432 FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487 L +EL +R +K + + ++ER+ N++ SKL E S+ A L Sbjct: 1775 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1828 Query: 488 KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELA 543 K A++ +QV AR+ Q L+++ K+L++ L ++ D+ RK EQ K++ Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE--RKMAEQY------KEQAE 1880 Query: 544 TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603 ++ L+ LE + + A +L++E D E++AL+ +L+ Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR---- 1936 Query: 604 KLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644 + + R +VI++A EE Sbjct: 1937 -------------RGNETSFVPSRRSGGRRVIENADGSEEE 1964 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 77.4 bits (189), Expect = 6e-14 Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%) Query: 383 EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439 E+ A+L++ K + + + +L+GH+S+L+ DL ++ R +A L EL+ Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157 Query: 440 LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480 L+ + EDT + + E+ K + ++E + ++++K+++ V+ Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217 Query: 481 --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523 N L ++NA++ ++ + QA+ ++E +KK+LE ++ + + Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277 Query: 524 GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562 G+R K Q ++E + L +++A+ +LQ Q L+ + Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337 Query: 563 EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612 + N + + +LE+ER+SL + + E +S L +L D++ KL AST E++ Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397 Query: 613 CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664 + K +K + + AA ++ N+L++ D L L + Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1449 Query: 665 SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721 S +E+ ++ + Q LA ++IS A + + A L E + L Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509 Query: 722 TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769 K E ++S ++ G + A T M ++++ + +EL Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569 Query: 770 RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809 L++ + L ++++ A E +++ L K Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629 Query: 810 AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868 GD ++L+ + I G ++ Q ++ L KD QRE+ ++ AS E +A Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1684 Query: 869 TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928 + KA A +M DL R + ++ + E+A A ++ D+ Sbjct: 1685 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1738 Query: 929 SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988 A++ Q + + + A + + ++ + + + + + Q+ +S + L Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1797 Query: 989 ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036 E +N+ ELR K +E+ G + + T EA L+E V ++ Sbjct: 1798 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840 Score = 62.8 bits (151), Expect = 2e-09 Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%) Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436 + R E+ + +L+ K Q+ +LK + + + L E+++L Q+ L AE Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 912 Query: 437 LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495 +E+R R ++ + L E+E + + E R +L+ + ++ Q DL + E Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972 Query: 496 VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555 + +V E + K+LED + + DQ + ++E+ ++LE +L T+ E + + Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1031 Query: 556 LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604 L + +E ELEK + L A+ E+++ L+ ++ + +++ Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091 Query: 605 LASTEESM 612 LA EE + Sbjct: 1092 LAKKEEEL 1099 Score = 60.5 bits (145), Expect = 8e-09 Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%) Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490 E ++A+ DEL++ +E +KA+ L E+E+K + ++ K E +Q +L + Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 914 Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537 E+ +++ +Q +LE E+E LE D+GQ+ +EQLE E+ Sbjct: 915 EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971 Query: 538 LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593 +Q+L T++ +++ L+ + + E LE+ L + A EE+ Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031 Query: 594 LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646 L K + + +++L E+S +L K +RK L G + I D Q+ E Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1089 Query: 647 LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706 + A + L + + + I Q + + ++ G H L L S+ A Sbjct: 1090 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1142 Query: 707 ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766 +A + D G E A LE + DSTA + L + Sbjct: 1143 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1184 Query: 767 LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824 +L + LD + V + + A+E T ++E+ +K+ LE N + Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244 Query: 825 GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884 G L QA Q + K L+ ++ E + + A+ + L + ++V T Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1300 Query: 885 VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944 M++ A+ GK +L + ++A+ ++QL +D+ L Q ++ + +N Sbjct: 1301 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1341 Query: 945 ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004 +T Q+EE N +L +EM+++ LE + +L + Sbjct: 1342 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1383 Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037 +KK + A E EEG + ++ + + E Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416 Score = 59.7 bits (143), Expect = 1e-08 Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%) Query: 324 EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381 + +L DD + + ++ L + + D+ + + N NK E L RL Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051 Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441 +E + +LE +K + + +++L+A +AE L+ Q A E L+A L L Sbjct: 1052 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1106 Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501 D E AQ++ K++E + DL + A K R Sbjct: 1107 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150 Query: 502 AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558 +LE K ELED+L+ + Q + + + + EV ++L +E + + ++Q ++ Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210 Query: 559 SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614 + + +F A L+K + +L A EL L + Q+ + K E + + Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270 Query: 615 LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668 L + G R AE + D +++L+ L G A L V S+SS + Sbjct: 1271 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324 Query: 669 EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728 + ++ LL T + +T LR E +SL + Sbjct: 1325 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1360 Query: 729 GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786 E + +LE S N + + L A E L G Q+E+ +L +E Sbjct: 1361 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1417 Query: 787 MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846 AA +E R+++ L D V L+ +++ + L+ K++ Sbjct: 1418 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472 Query: 847 EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905 + E R A +E K +S ++A+ + + + E+L+ Sbjct: 1473 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525 Query: 906 CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962 ++ + +L A + + ++ L +L+ + A + + + K Q E Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585 Query: 963 TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010 D + + KR+++ Q+ E E E +++++ L KK E Sbjct: 1586 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630 Score = 56.2 bits (134), Expect = 2e-07 Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%) Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434 R++ + L++ E L+ H+S L L++ + Q A E L + Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405 Query: 435 AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480 E++ L +Q E+ A L + + + Q + QR K + K+ +L+ Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465 Query: 481 NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518 ++ K A+ TK +S+AR +A+ +LER K E+ED + Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525 Query: 519 RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575 D G+ + ++ LE+ +E+ T EL+ LQ + + + E N A + E+ Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585 Query: 576 ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633 + L + EE+ L+++L +T+L+ + ++ AK + + L A+ Sbjct: 1586 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642 Query: 634 VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681 I ++A+ QL + L S D + +T + LE + + Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1699 Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741 ED++ A L + +A + L S A + R A +A LEE Sbjct: 1700 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1750 Query: 742 EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778 E E + AM + + K E+L + L K E Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810 Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSK 807 + V + +T AA+E A++EE + + Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839 Score = 55.5 bits (132), Expect = 3e-07 Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%) Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427 ++ + +L R++ + +LE+ + + +L+G + +LE R++A Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651 Query: 428 DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487 L+A++ + +R+ ED A+ S EI A+ NE++ L+ ADL++ Sbjct: 1652 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1698 Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547 ++ +QA ++ E +EL SL G+ Q++ LE+ +A + Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1750 Query: 548 ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607 EL+ QG++E + + +L E + S A E L ++ ++ + KL Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810 Query: 608 TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638 E ++ K L + EQV Q+A Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841 Score = 52.0 bits (123), Expect = 3e-06 Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%) Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429 K E + ++ + + + + + ++ E +++ Q+ +LE + A +Q L+ + Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983 Query: 430 CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489 ++ DE+ + K + ERK L+E+ S+L N A+ K Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1029 Query: 490 AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539 +T K SM + +V L++E+K + + L+R + EQ+ L++ LK Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089 Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588 +LA + ELQ L+ + N + ELE ++ L S A R Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149 Query: 589 ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644 EEL AL+ EL+DT A+ +E + +R+ + +KA ++ + Q++E Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1203 Score = 46.2 bits (108), Expect = 2e-04 Identities = 50/203 (24%), Positives = 95/203 (46%), Gaps = 31/203 (15%) Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431 EK+ L E L +SG A L++ K + + QL+ + E + ++ ++A E Sbjct: 1716 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774 Query: 432 FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487 L +EL +R +K + + ++ER+ N++ SKL E S+ A L Sbjct: 1775 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1828 Query: 488 KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQ----------------RK 527 K A++ +QV AR+ Q L+++ K+L++ L ++ D+ + ++ Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888 Query: 528 TQEQLEVLESLKQELATSQRELQ 550 + QLE E Q + ++R+LQ Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQ 1911 >gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo sapiens] Length = 1938 Score = 77.4 bits (189), Expect = 6e-14 Identities = 148/772 (19%), Positives = 311/772 (40%), Gaps = 147/772 (19%) Query: 383 EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439 E+ A+L++ K + + + +L+GH+S+L+ DL ++ R +A L EL+ Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150 Query: 440 LRRQREDTEKAQRSLSEIERKAQ---------------ANEQRYSKLKEKYSELVQ---- 480 L+ + EDT + + E+ K + ++E + ++++K+++ V+ Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210 Query: 481 --------------NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ--- 523 N L ++NA++ ++ + QA+ ++E +KK+LE ++ + + Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270 Query: 524 GQR----------KTQEQLEVLES-----------LKQELATSQRELQVLQGSLETSAQS 562 G+R K Q ++E + L +++A+ +LQ Q L+ + Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330 Query: 563 EANWAAEFAELEKERDSL-------VSGAAHREEELSALRKELQDTQLKL---ASTEESM 612 + N + + +LE+ER+SL + + E +S L +L D++ KL AST E++ Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390 Query: 613 CQLAKDQRKML-----LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHL---LSTVTSI 664 + K +K + + AA ++ N+L++ D L L + Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ--------ELDDLVVDLDNQRQL 1442 Query: 665 SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS---DAIAHGATTCLRAPPEPADSL 721 S +E+ ++ + Q LA ++IS A + + A L E + L Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502 Query: 722 TEACKQYGRETLAYLASLEEEG-------SLENADSTAMRNCLSKIKAIGEEL-----LP 769 K E ++S ++ G + A T M ++++ + +EL Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562 Query: 770 RGLDIKQEELGDLVDKEMAATSAAIETATARIEEML--------------------SKSR 809 L++ + L ++++ A E +++ L K Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622 Query: 810 AGD-TGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRW 868 GD ++L+ + I G ++ Q ++ L KD QRE+ ++ AS E +A Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDA---RASRDEIFATAKE- 1677 Query: 869 TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928 + KA A +M DL R + ++ + E+A A ++ D+ Sbjct: 1678 -----NEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEELASSLSGRNALQDEK 1731 Query: 929 SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988 A++ Q + + + A + + ++ + + + + + Q+ +S + L Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-NELATERSTAQKNESARQQL 1790 Query: 989 ELENELQKERQKLGELRKKHYELAGVAEGWEEGT----EASPPTLQEVVTEK 1036 E +N+ ELR K +E+ G + + T EA L+E V ++ Sbjct: 1791 ERQNK---------ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833 Score = 62.8 bits (151), Expect = 2e-09 Identities = 55/248 (22%), Positives = 114/248 (45%), Gaps = 14/248 (5%) Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436 + R E+ + +L+ K Q+ +LK + + + L E+++L Q+ L AE Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAE 905 Query: 437 LDELR-RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQ 495 +E+R R ++ + L E+E + + E R +L+ + ++ Q DL + E Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965 Query: 496 VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555 + +V E + K+LED + + DQ + ++E+ ++LE +L T+ E + + Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAKN 1024 Query: 556 LETSAQSEANWAAEF-----------AELEKERDSLVSGAAHREEELSALRKELQDTQLK 604 L + +E ELEK + L A+ E+++ L+ ++ + +++ Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084 Query: 605 LASTEESM 612 LA EE + Sbjct: 1085 LAKKEEEL 1092 Score = 60.5 bits (145), Expect = 8e-09 Identities = 135/633 (21%), Positives = 256/633 (40%), Gaps = 101/633 (15%) Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490 E ++A+ DEL++ +E +KA+ L E+E+K + ++ K E +Q +L + Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAE 907 Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR-------------KTQEQLEVLES 537 E+ +++ +Q +LE E+E LE D+GQ+ +EQLE E+ Sbjct: 908 EMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964 Query: 538 LKQEL----ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593 +Q+L T++ +++ L+ + + E LE+ L + A EE+ Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024 Query: 594 LRK-------ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646 L K + + +++L E+S +L K +RK L G + I D Q+ E Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIADLQAQIAELK 1082 Query: 647 LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706 + A + L + + + I Q + + ++ G H L L S+ A Sbjct: 1083 M-QLAKKEEELQAALARLDDEIAQKNNALKKI----RELEG--HISDLQEDLDSERAARN 1135 Query: 707 ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766 +A + D G E A LE + DSTA + L + Sbjct: 1136 -----KAEKQKRD--------LGEELEALKTELE-----DTLDSTATQQELRAKREQEVT 1177 Query: 767 LLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-LSKSRAGDTGVKLE-VNERIL 824 +L + LD + V + + A+E T ++E+ +K+ LE N + Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237 Query: 825 GCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGAT 884 G L QA Q + K L+ ++ E + + A+ + L + ++V T Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----T 1293 Query: 885 VMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQ 944 M++ A+ GK +L + ++A+ ++QL +D+ L Q ++ + +N Sbjct: 1294 GMLNEAE------GKAIKL---AKDVASLSSQL---------QDTQELLQ-EETRQKLNV 1334 Query: 945 ATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGEL 1004 +T Q+EE N +L +EM+++ LE + +L + Sbjct: 1335 STK---------LRQLEEERN------SLQDQLDEEMEAK---QNLERHISTLNIQLSDS 1376 Query: 1005 RKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037 +KK + A E EEG + ++ + + E Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409 Score = 59.7 bits (143), Expect = 1e-08 Identities = 141/709 (19%), Positives = 270/709 (38%), Gaps = 92/709 (12%) Query: 324 EPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEK--DHLIERLY 381 + +L DD + + ++ L + + D+ + + N NK E L RL Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044 Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441 +E + +LE +K + + +++L+A +AE L+ Q A E L+A L L Sbjct: 1045 KEEKS-RQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAALARL- 1099 Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501 D E AQ++ K++E + DL + A K R Sbjct: 1100 ----DDEIAQKN------------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143 Query: 502 AQVDLEREKKELEDSLERISDQGQRKTQEQLEVL---ESLKQELATSQRELQVLQGSLET 558 +LE K ELED+L+ + Q + + + + EV ++L +E + + ++Q ++ Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203 Query: 559 SAQSEANWAAEF----AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614 + + +F A L+K + +L A EL L + Q+ + K E + + Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263 Query: 615 LAKDQRKMLLVGSRKAAEQVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCI 668 L + G R AE + D +++L+ L G A L V S+SS + Sbjct: 1264 L----QSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317 Query: 669 EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQY 728 + ++ LL T + +T LR E +SL + Sbjct: 1318 QDTQE--------------------LLQEETRQKL--NVSTKLRQLEEERNSLQDQLD-- 1353 Query: 729 GRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KE 786 E + +LE S N + + L A E L G Q+E+ +L +E Sbjct: 1354 --EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEE 1410 Query: 787 MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQR 846 AA +E R+++ L D V L+ +++ + L+ K++ Sbjct: 1411 KAAAYDKLEKTKNRLQQELD-----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465 Query: 847 EIV-ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMV 905 + E R A +E K +S ++A+ + + + E+L+ Sbjct: 1466 KYADERDRAEAEAREKETK-------ALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518 Query: 906 CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962 ++ + +L A + + ++ L +L+ + A + + + K Q E Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578 Query: 963 TDNMDFSSM-TLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010 D + + KR+++ Q+ E E E +++++ L KK E Sbjct: 1579 ----DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623 Score = 56.2 bits (134), Expect = 2e-07 Identities = 106/509 (20%), Positives = 196/509 (38%), Gaps = 98/509 (19%) Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL-------R 434 R++ + L++ E L+ H+S L L++ + Q A E L + Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398 Query: 435 AELDELRRQREDTEKAQRSLSEIERKAQ---------ANEQR-----YSKLKEKYSELVQ 480 E++ L +Q E+ A L + + + Q + QR K + K+ +L+ Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458 Query: 481 NHADLLRKNAE------------VTKQVSMAR------QAQVDLEREKK----ELEDSLE 518 ++ K A+ TK +S+AR +A+ +LER K E+ED + Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518 Query: 519 RISDQGQ--RKTQEQLEVLESLKQELATSQRELQ-VLQGSLETSAQSEANWAAEFAELEK 575 D G+ + ++ LE+ +E+ T EL+ LQ + + + E N A + E+ Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578 Query: 576 ERDSLVSGAAHREEELSALRKELQ--DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633 + L + EE+ L+++L +T+L+ + ++ AK + + L A+ Sbjct: 1579 D---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635 Query: 634 VI---QDALNQLE---------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681 I ++A+ QL + L S D + +T + LE + + Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE---ADLMQL 1692 Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741 ED++ A L + +A + L S A + R A +A LEE Sbjct: 1693 QEDLAA-AERARKQADLEKEELAEELASSL--------SGRNALQDEKRRLEARIAQLEE 1743 Query: 742 EGSLENADSTAMRNCLSKIKAIGEEL-----------------------LPRGLDIKQEE 778 E E + AM + + K E+L + L K E Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803 Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSK 807 + V + +T AA+E A++EE + + Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832 Score = 55.5 bits (132), Expect = 3e-07 Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 24/271 (8%) Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVL---QLKGHVSELEADLAEQQHLRQQAA 427 ++ + +L R++ + +LE+ + + +L+G + +LE R++A Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644 Query: 428 DDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487 L+A++ + +R+ ED A+ S EI A+ NE++ L+ ADL++ Sbjct: 1645 KQLRKLQAQMKDFQRELED---ARASRDEIFATAKENEKKAKSLE----------ADLMQ 1691 Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547 ++ +QA ++ E +EL SL G+ Q++ LE+ +A + Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLS-----GRNALQDEKRRLEA---RIAQLEE 1743 Query: 548 ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607 EL+ QG++E + + +L E + S A E L ++ ++ + KL Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803 Query: 608 TEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638 E ++ K L + EQV Q+A Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834 Score = 52.0 bits (123), Expect = 3e-06 Identities = 67/299 (22%), Positives = 129/299 (43%), Gaps = 43/299 (14%) Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429 K E + ++ + + + + + ++ E +++ Q+ +LE + A +Q L+ + Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976 Query: 430 CEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN 489 ++ DE+ + K + ERK L+E+ S+L N A+ K Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSK-----ERKL---------LEERISDLTTNLAEEEEKA 1022 Query: 490 AEVT----KQVSMARQAQVDLEREKKELE--DSLERISDQGQRKTQEQLEVLES----LK 539 +T K SM + +V L++E+K + + L+R + EQ+ L++ LK Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082 Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHRE------- 588 +LA + ELQ L+ + N + ELE ++ L S A R Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142 Query: 589 ---EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644 EEL AL+ EL+DT A+ +E + +R+ + +KA ++ + Q++E Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1196 Score = 46.2 bits (108), Expect = 2e-04 Identities = 50/203 (24%), Positives = 95/203 (46%), Gaps = 31/203 (15%) Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431 EK+ L E L +SG A L++ K + + QL+ + E + ++ ++A E Sbjct: 1709 EKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767 Query: 432 FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY----SELVQNHADLLR 487 L +EL +R +K + + ++ER+ N++ SKL E S+ A L Sbjct: 1768 QLS---NELATERSTAQKNESARQQLERQ---NKELRSKLHEMEGAVKSKFKSTIAALEA 1821 Query: 488 KNAEVTKQVSM-ARQAQV---DLEREKKELEDSLERISDQGQ----------------RK 527 K A++ +QV AR+ Q L+++ K+L++ L ++ D+ + ++ Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881 Query: 528 TQEQLEVLESLKQELATSQRELQ 550 + QLE E Q + ++R+LQ Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQ 1904 >gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] Length = 2003 Score = 75.1 bits (183), Expect = 3e-13 Identities = 141/709 (19%), Positives = 267/709 (37%), Gaps = 124/709 (17%) Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENM-------KTESQRVVLQLKGHVSELEADL 416 S ++EK + +L + A +E+ + E +++ +L G SEL+ + Sbjct: 1037 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1096 Query: 417 AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS 476 EQQ ++ LRA+L E+ Q +L+ E + A Q L+E + Sbjct: 1097 VEQQQRAEE-------LRAQLGRKE------EELQAALARAEDEGGARAQLLKSLREAQA 1143 Query: 477 ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ---RKTQEQLE 533 L + DL + TK R +LE + ELED+L+ + Q + ++ QE E Sbjct: 1144 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1203 Query: 534 VLESLKQELATSQRELQVLQ-----------GSLETSAQSEANW-------AAEFAELEK 575 + ++L++E + +Q L+ LE + + + W AE +EL Sbjct: 1204 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1263 Query: 576 ERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVI 635 E SL + E+ L +LQ+ Q + E + + A+ ++ +A + + Sbjct: 1264 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR------AQAELENV 1317 Query: 636 QDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695 ALN+ E + + L ST + E L++ LA + + Sbjct: 1318 SGALNEAESKTI----RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM------- 1366 Query: 696 AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASL--------EEEGSLEN 747 +A A G E + A ++ GRE A L EE G+LE Sbjct: 1367 -----EAEAAGLR-------EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1413 Query: 748 ADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSK 807 A A R + +A+ + L E T +E R+++ L Sbjct: 1414 AGEEARRRAAREAEALTQRL-----------------AEKTETVDRLERGRRRLQQELD- 1455 Query: 808 SRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK-DLQREIVESGRGTASPKEFYAKNS 866 D + LE +++ + L+ K + R + E R A +E A+ Sbjct: 1456 ----DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1511 Query: 867 RWTEGLISASKAVGWGATVMVDAADLVVQG---RGKFEELMVCSHEIAASTAQLVAASKV 923 T L +A +L Q R + E L+ ++ S +L A +V Sbjct: 1512 SLTRALEEEQEA----------REELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1561 Query: 924 KADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDS 983 + AQ+ + + A + ++ ++ + + + +R+++ Sbjct: 1562 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1621 Query: 984 QVRVLELENELQKERQKL---------GELRKKHYELAGVAEGWEEGTE 1023 Q+R E+E + +++++ L GEL + ++A +G EE + Sbjct: 1622 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1670 Score = 53.9 bits (128), Expect = 8e-07 Identities = 78/337 (23%), Positives = 141/337 (41%), Gaps = 58/337 (17%) Query: 379 RLYREISGLKAQ----LENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLR 434 RL + LK Q L+ + QL + + E + E++ R A + L Sbjct: 1589 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1648 Query: 435 AELDELRRQ-------REDTEKAQRSLS--------EIERKAQANEQRYSKLKEKYSELV 479 EL+EL+ Q +E+ K R + E+E + E+ +S+ +E L Sbjct: 1649 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1708 Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLE-----------------REKKELEDSLERISD 522 A++LR E+ RQAQ D + EK++LE L ++ Sbjct: 1709 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL-- 1766 Query: 523 QGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF----AELEKERD 578 +E+LE +S + L R+L + SL T +E +++A+ +LE++ Sbjct: 1767 ------EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1820 Query: 579 SLVSGAAHREEELSALRK-ELQDTQLKLASTEESMCQLAKDQRKMLLVGSR-KAAEQVIQ 636 L + A K + + KLA EE QL ++ R+ +L G + AE+ ++ Sbjct: 1821 ELRGRLGEEDAGARARHKMTIAALESKLAQAEE---QLEQETRERILSGKLVRRAEKRLK 1877 Query: 637 DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673 + + Q+EE + AD L + + ++QL++ Sbjct: 1878 EVVLQVEEERRV-----ADQLRDQLEKGNLRVKQLKR 1909 Score = 53.5 bits (127), Expect = 1e-06 Identities = 131/637 (20%), Positives = 248/637 (38%), Gaps = 113/637 (17%) Query: 390 QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTE 448 +++ ++ +S R V +L+G V++LE E+ L +Q + E L AE +E R R + Sbjct: 888 KVQELQQQSAREVGELQGRVAQLE---EERARLAEQLRAEAE-LCAEAEETRGRLAARKQ 943 Query: 449 KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ-VDLE 507 + + +SE+E + E+ S+ + + +Q H L + E + Q + V E Sbjct: 944 ELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 1002 Query: 508 REKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWA 567 + K+ E+ L + DQ + ++E+ + + L + + + E + ++ + + EA A Sbjct: 1003 AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1062 Query: 568 AEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGS 627 L KE +EL L++ L +L Q A++ R L Sbjct: 1063 DMEDRLRKEEKG--------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL---G 1111 Query: 628 RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISG 687 RK E+ +Q AL + E+ G+ LL ++ + + + ++ Sbjct: 1112 RK--EEELQAALARAEDE-----GGARAQLLKSLREAQAALAEAQED------------- 1151 Query: 688 LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQ---YGRETLAYLASLEEEGS 744 L S+ +A T+A KQ G E A LE Sbjct: 1152 ----------LESERVAR----------------TKAEKQRRDLGEELEALRGELE---- 1181 Query: 745 LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804 + DST N ++++ E+ + EL +++E AA++ R + Sbjct: 1182 -DTLDST---NAQQELRSKREQ--------EVTELKKTLEEETRIHEAAVQELRQRHGQA 1229 Query: 805 LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864 L G+ +LE R G A++ + +L+ E+ S TA +E + Sbjct: 1230 L-----GELAEQLEQARRGKGAWEKTRLALEAEV---SELRAEL--SSLQTAR-QEGEQR 1278 Query: 865 NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924 R L G G +AA+ + + + + E + +E + T +L Sbjct: 1279 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL------- 1331 Query: 925 ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQ 984 + + S AQL A + + T +A ++ E + R++++ + Sbjct: 1332 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL-----------REQLEEE 1380 Query: 985 VRVLE-LENELQKERQKLGELRKKHYELAGVAEGWEE 1020 E ELQ + +L E R++ E AG E EE Sbjct: 1381 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEE 1417 >gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] Length = 1995 Score = 75.1 bits (183), Expect = 3e-13 Identities = 141/709 (19%), Positives = 267/709 (37%), Gaps = 124/709 (17%) Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENM-------KTESQRVVLQLKGHVSELEADL 416 S ++EK + +L + A +E+ + E +++ +L G SEL+ + Sbjct: 1029 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1088 Query: 417 AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS 476 EQQ ++ LRA+L E+ Q +L+ E + A Q L+E + Sbjct: 1089 VEQQQRAEE-------LRAQLGRKE------EELQAALARAEDEGGARAQLLKSLREAQA 1135 Query: 477 ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ---RKTQEQLE 533 L + DL + TK R +LE + ELED+L+ + Q + ++ QE E Sbjct: 1136 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1195 Query: 534 VLESLKQELATSQRELQVLQ-----------GSLETSAQSEANW-------AAEFAELEK 575 + ++L++E + +Q L+ LE + + + W AE +EL Sbjct: 1196 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1255 Query: 576 ERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVI 635 E SL + E+ L +LQ+ Q + E + + A+ ++ +A + + Sbjct: 1256 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR------AQAELENV 1309 Query: 636 QDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695 ALN+ E + + L ST + E L++ LA + + Sbjct: 1310 SGALNEAESKTI----RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM------- 1358 Query: 696 AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASL--------EEEGSLEN 747 +A A G E + A ++ GRE A L EE G+LE Sbjct: 1359 -----EAEAAGLR-------EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1405 Query: 748 ADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSK 807 A A R + +A+ + L E T +E R+++ L Sbjct: 1406 AGEEARRRAAREAEALTQRL-----------------AEKTETVDRLERGRRRLQQELD- 1447 Query: 808 SRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK-DLQREIVESGRGTASPKEFYAKNS 866 D + LE +++ + L+ K + R + E R A +E A+ Sbjct: 1448 ----DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1503 Query: 867 RWTEGLISASKAVGWGATVMVDAADLVVQG---RGKFEELMVCSHEIAASTAQLVAASKV 923 T L +A +L Q R + E L+ ++ S +L A +V Sbjct: 1504 SLTRALEEEQEA----------REELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1553 Query: 924 KADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDS 983 + AQ+ + + A + ++ ++ + + + +R+++ Sbjct: 1554 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1613 Query: 984 QVRVLELENELQKERQKL---------GELRKKHYELAGVAEGWEEGTE 1023 Q+R E+E + +++++ L GEL + ++A +G EE + Sbjct: 1614 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1662 Score = 53.9 bits (128), Expect = 8e-07 Identities = 78/337 (23%), Positives = 141/337 (41%), Gaps = 58/337 (17%) Query: 379 RLYREISGLKAQ----LENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLR 434 RL + LK Q L+ + QL + + E + E++ R A + L Sbjct: 1581 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1640 Query: 435 AELDELRRQ-------REDTEKAQRSLS--------EIERKAQANEQRYSKLKEKYSELV 479 EL+EL+ Q +E+ K R + E+E + E+ +S+ +E L Sbjct: 1641 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1700 Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLE-----------------REKKELEDSLERISD 522 A++LR E+ RQAQ D + EK++LE L ++ Sbjct: 1701 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL-- 1758 Query: 523 QGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF----AELEKERD 578 +E+LE +S + L R+L + SL T +E +++A+ +LE++ Sbjct: 1759 ------EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1812 Query: 579 SLVSGAAHREEELSALRK-ELQDTQLKLASTEESMCQLAKDQRKMLLVGSR-KAAEQVIQ 636 L + A K + + KLA EE QL ++ R+ +L G + AE+ ++ Sbjct: 1813 ELRGRLGEEDAGARARHKMTIAALESKLAQAEE---QLEQETRERILSGKLVRRAEKRLK 1869 Query: 637 DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673 + + Q+EE + AD L + + ++QL++ Sbjct: 1870 EVVLQVEEERRV-----ADQLRDQLEKGNLRVKQLKR 1901 Score = 53.5 bits (127), Expect = 1e-06 Identities = 131/637 (20%), Positives = 248/637 (38%), Gaps = 113/637 (17%) Query: 390 QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTE 448 +++ ++ +S R V +L+G V++LE E+ L +Q + E L AE +E R R + Sbjct: 880 KVQELQQQSAREVGELQGRVAQLE---EERARLAEQLRAEAE-LCAEAEETRGRLAARKQ 935 Query: 449 KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ-VDLE 507 + + +SE+E + E+ S+ + + +Q H L + E + Q + V E Sbjct: 936 ELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 994 Query: 508 REKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWA 567 + K+ E+ L + DQ + ++E+ + + L + + + E + ++ + + EA A Sbjct: 995 AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1054 Query: 568 AEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGS 627 L KE +EL L++ L +L Q A++ R L Sbjct: 1055 DMEDRLRKEEKG--------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL---G 1103 Query: 628 RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISG 687 RK E+ +Q AL + E+ G+ LL ++ + + + ++ Sbjct: 1104 RK--EEELQAALARAEDE-----GGARAQLLKSLREAQAALAEAQED------------- 1143 Query: 688 LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQ---YGRETLAYLASLEEEGS 744 L S+ +A T+A KQ G E A LE Sbjct: 1144 ----------LESERVAR----------------TKAEKQRRDLGEELEALRGELE---- 1173 Query: 745 LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804 + DST N ++++ E+ + EL +++E AA++ R + Sbjct: 1174 -DTLDST---NAQQELRSKREQ--------EVTELKKTLEEETRIHEAAVQELRQRHGQA 1221 Query: 805 LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864 L G+ +LE R G A++ + +L+ E+ S TA +E + Sbjct: 1222 L-----GELAEQLEQARRGKGAWEKTRLALEAEV---SELRAEL--SSLQTAR-QEGEQR 1270 Query: 865 NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924 R L G G +AA+ + + + + E + +E + T +L Sbjct: 1271 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL------- 1323 Query: 925 ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQ 984 + + S AQL A + + T +A ++ E + R++++ + Sbjct: 1324 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL-----------REQLEEE 1372 Query: 985 VRVLE-LENELQKERQKLGELRKKHYELAGVAEGWEE 1020 E ELQ + +L E R++ E AG E EE Sbjct: 1373 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEE 1409 >gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] Length = 2036 Score = 75.1 bits (183), Expect = 3e-13 Identities = 141/709 (19%), Positives = 267/709 (37%), Gaps = 124/709 (17%) Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENM-------KTESQRVVLQLKGHVSELEADL 416 S ++EK + +L + A +E+ + E +++ +L G SEL+ + Sbjct: 1070 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1129 Query: 417 AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS 476 EQQ ++ LRA+L E+ Q +L+ E + A Q L+E + Sbjct: 1130 VEQQQRAEE-------LRAQLGRKE------EELQAALARAEDEGGARAQLLKSLREAQA 1176 Query: 477 ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ---RKTQEQLE 533 L + DL + TK R +LE + ELED+L+ + Q + ++ QE E Sbjct: 1177 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1236 Query: 534 VLESLKQELATSQRELQVLQ-----------GSLETSAQSEANW-------AAEFAELEK 575 + ++L++E + +Q L+ LE + + + W AE +EL Sbjct: 1237 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1296 Query: 576 ERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVI 635 E SL + E+ L +LQ+ Q + E + + A+ ++ +A + + Sbjct: 1297 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR------AQAELENV 1350 Query: 636 QDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695 ALN+ E + + L ST + E L++ LA + + Sbjct: 1351 SGALNEAESKTI----RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM------- 1399 Query: 696 AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASL--------EEEGSLEN 747 +A A G E + A ++ GRE A L EE G+LE Sbjct: 1400 -----EAEAAGLR-------EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1446 Query: 748 ADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSK 807 A A R + +A+ + L E T +E R+++ L Sbjct: 1447 AGEEARRRAAREAEALTQRL-----------------AEKTETVDRLERGRRRLQQELD- 1488 Query: 808 SRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASK-DLQREIVESGRGTASPKEFYAKNS 866 D + LE +++ + L+ K + R + E R A +E A+ Sbjct: 1489 ----DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1544 Query: 867 RWTEGLISASKAVGWGATVMVDAADLVVQG---RGKFEELMVCSHEIAASTAQLVAASKV 923 T L +A +L Q R + E L+ ++ S +L A +V Sbjct: 1545 SLTRALEEEQEA----------REELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1594 Query: 924 KADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDS 983 + AQ+ + + A + ++ ++ + + + +R+++ Sbjct: 1595 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1654 Query: 984 QVRVLELENELQKERQKL---------GELRKKHYELAGVAEGWEEGTE 1023 Q+R E+E + +++++ L GEL + ++A +G EE + Sbjct: 1655 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1703 Score = 53.9 bits (128), Expect = 8e-07 Identities = 78/337 (23%), Positives = 141/337 (41%), Gaps = 58/337 (17%) Query: 379 RLYREISGLKAQ----LENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLR 434 RL + LK Q L+ + QL + + E + E++ R A + L Sbjct: 1622 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1681 Query: 435 AELDELRRQ-------REDTEKAQRSLS--------EIERKAQANEQRYSKLKEKYSELV 479 EL+EL+ Q +E+ K R + E+E + E+ +S+ +E L Sbjct: 1682 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1741 Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLE-----------------REKKELEDSLERISD 522 A++LR E+ RQAQ D + EK++LE L ++ Sbjct: 1742 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL-- 1799 Query: 523 QGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF----AELEKERD 578 +E+LE +S + L R+L + SL T +E +++A+ +LE++ Sbjct: 1800 ------EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1853 Query: 579 SLVSGAAHREEELSALRK-ELQDTQLKLASTEESMCQLAKDQRKMLLVGSR-KAAEQVIQ 636 L + A K + + KLA EE QL ++ R+ +L G + AE+ ++ Sbjct: 1854 ELRGRLGEEDAGARARHKMTIAALESKLAQAEE---QLEQETRERILSGKLVRRAEKRLK 1910 Query: 637 DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673 + + Q+EE + AD L + + ++QL++ Sbjct: 1911 EVVLQVEEERRV-----ADQLRDQLEKGNLRVKQLKR 1942 Score = 53.5 bits (127), Expect = 1e-06 Identities = 131/637 (20%), Positives = 248/637 (38%), Gaps = 113/637 (17%) Query: 390 QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTE 448 +++ ++ +S R V +L+G V++LE E+ L +Q + E L AE +E R R + Sbjct: 921 KVQELQQQSAREVGELQGRVAQLE---EERARLAEQLRAEAE-LCAEAEETRGRLAARKQ 976 Query: 449 KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ-VDLE 507 + + +SE+E + E+ S+ + + +Q H L + E + Q + V E Sbjct: 977 ELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 1035 Query: 508 REKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWA 567 + K+ E+ L + DQ + ++E+ + + L + + + E + ++ + + EA A Sbjct: 1036 AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1095 Query: 568 AEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGS 627 L KE +EL L++ L +L Q A++ R L Sbjct: 1096 DMEDRLRKEEKG--------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL---G 1144 Query: 628 RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISG 687 RK E+ +Q AL + E+ G+ LL ++ + + + ++ Sbjct: 1145 RK--EEELQAALARAEDE-----GGARAQLLKSLREAQAALAEAQED------------- 1184 Query: 688 LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQ---YGRETLAYLASLEEEGS 744 L S+ +A T+A KQ G E A LE Sbjct: 1185 ----------LESERVAR----------------TKAEKQRRDLGEELEALRGELE---- 1214 Query: 745 LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804 + DST N ++++ E+ + EL +++E AA++ R + Sbjct: 1215 -DTLDST---NAQQELRSKREQ--------EVTELKKTLEEETRIHEAAVQELRQRHGQA 1262 Query: 805 LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864 L G+ +LE R G A++ + +L+ E+ S TA +E + Sbjct: 1263 L-----GELAEQLEQARRGKGAWEKTRLALEAEV---SELRAEL--SSLQTAR-QEGEQR 1311 Query: 865 NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924 R L G G +AA+ + + + + E + +E + T +L Sbjct: 1312 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL------- 1364 Query: 925 ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQ 984 + + S AQL A + + T +A ++ E + R++++ + Sbjct: 1365 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL-----------REQLEEE 1413 Query: 985 VRVLE-LENELQKERQKLGELRKKHYELAGVAEGWEE 1020 E ELQ + +L E R++ E AG E EE Sbjct: 1414 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEE 1450 >gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] Length = 2017 Score = 75.1 bits (183), Expect = 3e-13 Identities = 148/708 (20%), Positives = 281/708 (39%), Gaps = 108/708 (15%) Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437 E RE+ L++ E + E + L+ V++ +A+ Q+ + QAA E LR + Sbjct: 585 EDAQREVQRLRSANELLSREKSNLAHSLQ--VAQQQAEELRQEREKLQAAQ--EELRRQR 640 Query: 438 DELRRQREDT-----------EKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLL 486 D L ++ED E++ R L ++E K + +++E S L Sbjct: 641 DRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ 700 Query: 487 RKNAEVTKQVSMARQAQVDLE-------REKKELEDSLERISDQGQRKTQEQLEVLESLK 539 + AEV + ++ A +V+LE E+ L+DSL ++S + Q++L+ L Sbjct: 701 AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLD----LN 756 Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAE------LEKE--RDSLVSGAAHREEEL 591 + +A + E LQG + A+ EA A E E LE+E R L E+ Sbjct: 757 RLVAQLEEEKSALQGR-QRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ 815 Query: 592 SALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCA 651 AL ++L + + + +E + QL++ L G + EQ ++A Q Sbjct: 816 EALEQQLPTLRHERSQLQEQLAQLSRQ-----LSGREQELEQARREAQRQ---------- 860 Query: 652 GSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCL 711 +E LE++ + A ++ +GL ++ L+A T L Sbjct: 861 ----------------VEALERAAREKEALAKEHAGL--AVQLVAAEREGRTLSEEATRL 902 Query: 712 RAPPEPAD-SLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPR 770 R E + SL E +Q LA LE A+ A+ L+K GE R Sbjct: 903 RLEKEALEGSLFEVQRQ--------LAQLEARREQLEAEGQAL--LLAKETLTGELAGLR 952 Query: 771 GLDIKQEELGDLVDKEMAA---------TSAAIETATARIEEMLSKSRAGDTGVKLEVNE 821 I +E L DKE+ A A++ A EE L + + E+ Sbjct: 953 QQIIATQEKASL-DKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011 Query: 822 RILGCCTSLMQAIQVLIVA----SKDLQREIV------ESGRGTASPKEFYAKNSRWTEG 871 + L + + L+ ++L EI + G A ++ A + + +E Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEK 1071 Query: 872 LISASKAVGWG---ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKD 928 + K +G AT+ ++ + + E+ + + + L A + A Sbjct: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH 1131 Query: 929 SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVL 988 + + +LQ+ +R + + + ++Q+ ++ ++R+ +++Q ++ Sbjct: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLED------ARDGLRRELLEAQRKLR 1185 Query: 989 ELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEK 1036 E + + +RQ+ GELR+ E A E E +++ +E+ Sbjct: 1186 ESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESER 1233 Score = 73.2 bits (178), Expect = 1e-12 Identities = 112/452 (24%), Positives = 189/452 (41%), Gaps = 60/452 (13%) Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436 + +L R++SG + +LE + E+QR V L+ E EA E L Q R Sbjct: 836 LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 895 Query: 437 LDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQV 496 +E R R + E + SL E++R+ E R +L+ + A LL K +T ++ Sbjct: 896 SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLE------AEGQALLLAKET-LTGEL 948 Query: 497 SMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSL 556 + RQ Q+ +EK L+ L Q+ Q + E SL+++ A + +LQ LQ Sbjct: 949 AGLRQ-QIIATQEKASLDKEL-----MAQKLVQAEREAQASLREQRAAHEEDLQRLQ--- 999 Query: 557 ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLA 616 + EA W ELE ER L S +EEL A R E + +L S E + Q Sbjct: 1000 ---REKEAAW----RELEAERAQLQSQLQREQEELLA-RLEAEKEEL---SEEIAALQQE 1048 Query: 617 KDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWS 676 +D+ +L AE Q AL+ E ++ L+ T S+++ ++E+ Sbjct: 1049 RDEGLLL-------AESEKQQALSLKESEK----TALSEKLMGTRHSLATISLEMERQKR 1097 Query: 677 QYLACPEDISGLLHSIT-----LLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRE 731 + E ++++T L A A AH + L E + G++ Sbjct: 1098 DAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA---------QEVRRLQEQARDLGKQ 1148 Query: 732 TLAYLASLEEEGS----LENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDK-- 785 + L EE + LE+A R L + + E G +++++E G+L Sbjct: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRES--QEGREVQRQEAGELRRSLG 1206 Query: 786 EMAATSAAIETATARIEEMLSKSRAGDTGVKL 817 E A A+ + + + K+ + +KL Sbjct: 1207 EGAKEREALRRSNEELRSAVKKAESERISLKL 1238 Score = 62.8 bits (151), Expect = 2e-09 Identities = 121/613 (19%), Positives = 246/613 (40%), Gaps = 71/613 (11%) Query: 437 LDELRRQREDTEKAQRSLSE----IERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492 L LR+Q D+E +R+L E + K Q + + + L + L R+ + + Sbjct: 549 LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNL 608 Query: 493 TKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLES---LKQELATSQREL 549 + +A+Q +L +E+++L+ + E + Q R +EQ + ++ +++EL S R+L Sbjct: 609 AHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQL 668 Query: 550 QVLQG--------------SLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALR 595 + L+G +L + AE AE+ + +G E ++ LR Sbjct: 669 EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728 Query: 596 KE---LQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAG 652 E LQD+ KL++ ES+ Q D + LV + + +Q Q E+ ++ Sbjct: 729 AEEASLQDSLSKLSALNESLAQDKLDLNR--LVAQLEEEKSALQGRQRQAEQEATVAREE 786 Query: 653 SADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLR 712 E+LE+ + + + G L +A +A+ T Sbjct: 787 Q---------------ERLEELRLEQEVARQGLEGSLR----VAEQAQEALEQQLPTLRH 827 Query: 713 APPEPADSLTEACKQY-GRETLAYLASLEEEGSLENADSTAM-RNCLSKIKA-IGEELLP 769 + + L + +Q GRE A E + +E + A + L+K A + +L+ Sbjct: 828 ERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVA 887 Query: 770 ---RGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILG- 825 G + +E ++KE A+E + ++ L++ A ++ E +L Sbjct: 888 AEREGRTLSEEATRLRLEKE------ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK 941 Query: 826 -CCTSLMQAIQVLIVASKD--------LQREIVESGR-GTASPKEFYAKNSRWTEGLISA 875 T + ++ I+A+++ + +++V++ R AS +E A + + L Sbjct: 942 ETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRL-QR 1000 Query: 876 SKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQL 935 K W + + A L Q + + EEL+ ++ +AA + + D+ Sbjct: 1001 EKEAAW-RELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESE 1059 Query: 936 QQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQ 995 +Q + + ++ ++ + G T +++ RQE D V L +EL+ Sbjct: 1060 KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST-VNALTSELR 1118 Query: 996 KERQKLGELRKKH 1008 R + E H Sbjct: 1119 DLRAQREEAAAAH 1131 Score = 56.6 bits (135), Expect = 1e-07 Identities = 58/268 (21%), Positives = 104/268 (38%), Gaps = 14/268 (5%) Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437 + L + S L QL M+ E + + +L+ +AE + R+ ++AEL Sbjct: 1526 DELRTQTSALNRQLAEMEAERDSATSRAR----QLQKAVAESEEARRSVDGRLSGVQAEL 1581 Query: 438 ----DELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493 + +RR + ++ +ER QA E +EK S++ N L + Sbjct: 1582 ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLK 1641 Query: 494 KQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQ 553 + + + V LE +++ LE L+R S G + Q + L+ L + +V Sbjct: 1642 EVLDASESRTVKLELQRRSLEGELQR-SRLGLSDREAQAQALQDRVDSLQRQVADSEVKA 1700 Query: 554 GSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMC 613 G+L+ + + A+ E E V G + SA +D L L Sbjct: 1701 GTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHL-----QKA 1755 Query: 614 QLAKDQRKMLLVGSRKAAEQVIQDALNQ 641 A + + +L AA Q + +A Q Sbjct: 1756 LTACEHDRQVLQERLDAARQALSEARKQ 1783 Score = 55.5 bits (132), Expect = 3e-07 Identities = 139/678 (20%), Positives = 249/678 (36%), Gaps = 92/678 (13%) Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441 RE L+ QL ++ L+ + E + L E Q R+ + LR L E Sbjct: 1154 REAEELRTQLRLLEDARDG----LRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGA 1209 Query: 442 RQREDTEKAQRSLSEIERKAQAN-----------EQRYSKLKEKYSELVQNHADLLRKNA 490 ++RE ++ L +KA++ EQ+ + L+E + + + +L Sbjct: 1210 KEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ 1269 Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQ----------GQRKTQEQLE------- 533 EV + AR+ +L R+ K L+ R+ + G+R +E Sbjct: 1270 EVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQ 1329 Query: 534 -------VLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAH 586 LE ++QEL +QR+LQ +G T + E EK++ + A Sbjct: 1330 RLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQ---LDHARG 1386 Query: 587 REEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646 E +L A R E + L+L++ E L + ++ + R+AAE + + L Sbjct: 1387 LELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEV--QRRAAEAQLGGLRSALRRG- 1443 Query: 647 LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHG 706 L + S + S ++ GL TL S + G Sbjct: 1444 -----------LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492 Query: 707 ATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766 T P D EA + RE L L S + E ++A+ L++++A + Sbjct: 1493 PAT----SPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDS 1548 Query: 767 LLPRGLDIKQ-----EELGDLVDKEMAATSA--AIETATARIEEMLSKSRAGDTGV---K 816 R +++ EE VD ++ A A++ + R E ++ Sbjct: 1549 ATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERS 1608 Query: 817 LEVNERILGCC---TSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLI 873 L+ E L S M+A + + K +E++++ E R EG + Sbjct: 1609 LQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLEL---QRRSLEGEL 1665 Query: 874 SASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLA 933 S+ +G +A +Q R + V E+ A T QL ++ + LA Sbjct: 1666 QRSR-LGLSDR---EAQAQALQDRVDSLQRQVADSEVKAGTLQLT------VERLNGALA 1715 Query: 934 QLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENE 993 +++++ + G+ + + + T D + + E D QV L+ Sbjct: 1716 KVEESEGALRDKVRGLTEALAQSSASLNST--RDKNLHLQKALTACEHDRQV----LQER 1769 Query: 994 LQKERQKLGELRKKHYEL 1011 L RQ L E RK+ L Sbjct: 1770 LDAARQALSEARKQSSSL 1787 Score = 53.9 bits (128), Expect = 8e-07 Identities = 60/288 (20%), Positives = 124/288 (43%), Gaps = 22/288 (7%) Query: 378 ERLYREISGLKAQLEN-MKTESQRVVLQLKGHVSELEADLAEQQHLRQQA-----ADDCE 431 E +RE+ +AQL++ ++ E + ++ +L+ EL ++A Q R + ++ + Sbjct: 1003 EAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQ 1062 Query: 432 FLRAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELVQNHADLLR 487 L + E E + SL+ E+ER+ + + R + + + L DL Sbjct: 1063 ALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA 1122 Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547 + E + + + R+ + DS R +++ + + + + + L++EL +QR Sbjct: 1123 QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182 Query: 548 ELQVLQGSLETSAQSEANWAAEFAELEKERDS-------LVSGAAHREEELSALRKELQD 600 +L+ Q E Q E KER++ L S E E +L+ +D Sbjct: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1242 Query: 601 TQLKLASTEESMCQLAKDQRKML-----LVGSRKAAEQVIQDALNQLE 643 + KLA EE+ + K+ ++ + SR A + +Q+ Q++ Sbjct: 1243 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290 Score = 53.1 bits (126), Expect = 1e-06 Identities = 56/276 (20%), Positives = 125/276 (45%), Gaps = 26/276 (9%) Query: 372 EKDHLIERLYREISGLKAQLENMKTES---QRVVLQLKGHVSELEADLAEQQHLRQQAAD 428 +++ + L + L+ Q+ + + ++ Q V +L G ++++E + LR + Sbjct: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES---EGALRDKVRG 1730 Query: 429 DCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRK 488 E L L R+ Q++L+ E Q ++R ++ SE ++ Sbjct: 1731 LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA-------RKQ 1783 Query: 489 NAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRE 548 ++ + +QV R DLE ++ E E L+++ + +++ + + L ++ Q+L +R Sbjct: 1784 SSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTV-QKLQDERRL 1842 Query: 549 LQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAST 608 LQ GSL+ + A+LE E+ + A E++ ALR+ L + + + Sbjct: 1843 LQERLGSLQRA----------LAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS 1892 Query: 609 EESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644 E +L+ ++ + L + AE + +A Q+++ Sbjct: 1893 HEDTVRLSAEKGR--LDRTLTGAELELAEAQRQIQQ 1926 Score = 52.4 bits (124), Expect = 2e-06 Identities = 50/217 (23%), Positives = 96/217 (44%), Gaps = 22/217 (10%) Query: 397 ESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSE 456 E R VLQ + + L+E + + + LR E+ +L QR + E + L E Sbjct: 1760 EHDRQVLQER--LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLRE 1817 Query: 457 IERKAQANE----QRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKE 512 + R+ Q E KL+++ L + L R A++ + ++ + LE+++ Sbjct: 1818 VLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVA 1877 Query: 513 LEDSLERISDQGQRKTQEQLEV----------LESLKQELATSQRELQVLQGSL------ 556 L +L+++ + R ++ + + L + ELA +QR++Q L+ + Sbjct: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQS 1937 Query: 557 ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA 593 + AQ E + + EL++E + L S A E L A Sbjct: 1938 HSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEA 1974 Score = 48.9 bits (115), Expect = 2e-05 Identities = 68/308 (22%), Positives = 121/308 (39%), Gaps = 47/308 (15%) Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSE--LEADLAEQQHLRQQAAD- 428 E+ L +L RE L A+LE K E + L+ E L A+ +QQ L + ++ Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEK 1071 Query: 429 -----------------DCEFLRAELDELRRQREDTEKAQRSLSEI-------ERKAQAN 464 E R + D RQ +D SE+ E A A+ Sbjct: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH 1131 Query: 465 EQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQG 524 Q +L+E+ +L + LR+ E+ Q+ + A+ L RE E + L + Sbjct: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR 1191 Query: 525 QRKTQEQLEVLESL-------------KQELATSQRELQVLQGSLETSAQSEANWAAEFA 571 + + QE E+ SL +EL ++ ++ + + SL+ + + + A Sbjct: 1192 EVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLE 1251 Query: 572 ELE----KERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM---LL 624 E KE L +G E R+ELQ+ + ++ + +L ++ ++ L Sbjct: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311 Query: 625 VGSRKAAE 632 +G R E Sbjct: 1312 LGERAEKE 1319 Score = 44.7 bits (104), Expect = 5e-04 Identities = 48/193 (24%), Positives = 91/193 (47%), Gaps = 20/193 (10%) Query: 376 LIERLYREISGLKAQLENM-KTESQRVVLQ-----LKGHVSELEADLAEQQHLRQQAADD 429 L E L + G A L + K + +R +LQ L+ +++LEA+ E + + D Sbjct: 1815 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKD 1874 Query: 430 CEFLRAELDELRRQR----EDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485 LR LD++ R++ EDT + ++R E +L E ++ Q A + Sbjct: 1875 RVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAEL---ELAEAQRQIQQLEAQV 1931 Query: 486 LRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE-SLKQELAT 544 + V +Q Q +VD ++++ EL+ +ER+ Q +T+ LE E + +Q + Sbjct: 1932 V-----VLEQSHSPAQLEVDAQQQQLELQQEVERLR-SAQAQTERTLEARERAHRQRVRG 1985 Query: 545 SQRELQVLQGSLE 557 + ++ L+G L+ Sbjct: 1986 LEEQVSTLKGQLQ 1998 Score = 39.7 bits (91), Expect = 0.015 Identities = 160/795 (20%), Positives = 298/795 (37%), Gaps = 162/795 (20%) Query: 380 LYREISGLKAQLENMKTESQRVVLQLKGHVSEL-----EADLAEQQHLR------QQAAD 428 L+R++ G + + +K ++R +LQL G ++ EA L LR + A + Sbjct: 299 LWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALE 358 Query: 429 DCEFLRAELDELRRQREDTEK--AQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLL 486 L+A+L+E R + EK AQ+ + KA + R ++L L + + + Sbjct: 359 KQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLS-ARVTELGLAVKRLEKQNLEKD 417 Query: 487 RKNAEVTKQV----SMARQAQVDLEREKKE-LEDSLERISDQGQRKTQEQLEVLESLKQE 541 + N ++T+++ S+ Q Q LE E E L+ +L ++ Q E L ++ Sbjct: 418 QVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLA-QAVLSDSESGVQLSGSERT 476 Query: 542 LATSQRELQVLQGSLETS-------------------AQSEANWAAEFAELEKERDSLVS 582 S L+ L G S A S+++ A +R V Sbjct: 477 ADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQ 536 Query: 583 GAAHREEE----LSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDA 638 R E L LRK+L D++ + + EE + Q +D+ G+ +A E ++ Sbjct: 537 DMRGRYEASQDLLGTLRKQLSDSESERRALEEQL-QRLRDKTD----GAMQAHEDAQREV 591 Query: 639 LNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698 L+S S +L ++ E+L + + A E+ L L Sbjct: 592 QRLRSANELLSREKS--NLAHSLQVAQQQAEELRQEREKLQAAQEE---LRRQRDRLEEE 646 Query: 699 TSDAIAHGA--------------------TTCLRAPPEPADSLTEACKQYG-----RETL 733 DA+ GA + + E ++L+ A Q + + Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706 Query: 734 AYLASLEEEGSLE--------NADSTAMRNCLSKIKAIGEELLPRGLDIK------QEEL 779 A + E G +E A+ ++++ LSK+ A+ E L LD+ +EE Sbjct: 707 AEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEK 766 Query: 780 GDLVDKEMAATSAA--IETATARIEEMLSKSRAGDTGV---------------------- 815 L ++ A A R+EE+ + G+ Sbjct: 767 SALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLR 826 Query: 816 --KLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK-NSRWTEGL 872 + ++ E++ L Q L A ++ QR+ VE+ A KE AK ++ L Sbjct: 827 HERSQLQEQLAQLSRQLSGREQELEQARREAQRQ-VEALERAAREKEALAKEHAGLAVQL 885 Query: 873 ISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIA--------------------- 911 ++A + G T+ +A L ++ L ++A Sbjct: 886 VAAERE---GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942 Query: 912 ------ASTAQLVAASKVKADKDSPNLAQ-LQQASRGVNQATAGVVASTISGKSQIEETD 964 A Q + A++ KA D +AQ L QA R +A A + + + ++ Sbjct: 943 TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER---EAQASLREQRAAHEEDLQRLQ 999 Query: 965 NMDFSSMTLTQIKRQEMDSQVR--VLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022 ++ + +R ++ SQ++ EL L+ E+++L E E+A + + +EG Sbjct: 1000 REKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSE------EIAALQQERDEGL 1053 Query: 1023 EASPPTLQEVVTEKE 1037 + Q+ ++ KE Sbjct: 1054 LLAESEKQQALSLKE 1068 Score = 38.5 bits (88), Expect = 0.033 Identities = 45/188 (23%), Positives = 86/188 (45%), Gaps = 18/188 (9%) Query: 372 EKDHLIERLYREISGLKAQLENMKTE--------SQRVVLQLKGHVSELEADLAEQQHLR 423 E++ L+++ + L AQ + E S+R+ L+ ELE E + L Sbjct: 81 EENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQ--EPRGLV 138 Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483 +Q+ + L+ E RR+ + ++ Q+ +++ ++ Q +Y K++ SEL Q Sbjct: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQY---KKRCSELEQQ-- 193 Query: 484 DLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQ--RKTQEQLEVLESLKQE 541 LL ++ E+ +Q + DLE LE+ +R + Q +EQL+ S Q Sbjct: 194 -LLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQA 252 Query: 542 LATSQREL 549 L+ R++ Sbjct: 253 LSEDIRKV 260 Score = 36.2 bits (82), Expect = 0.16 Identities = 31/108 (28%), Positives = 54/108 (50%), Gaps = 16/108 (14%) Query: 383 EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442 E+ +AQ + + E+Q VVL+ ++LE D A+QQ L L+ E++ LR Sbjct: 1914 ELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVD-AQQQQLE---------LQQEVERLRS 1963 Query: 443 QREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490 + TE+ +E + +A+ QR L+E+ S L LR+++ Sbjct: 1964 AQAQTERT------LEARERAHRQRVRGLEEQVSTLKGQLQQELRRSS 2005 >gi|42794779 myosin 18A isoform b [Homo sapiens] Length = 2039 Score = 75.1 bits (183), Expect = 3e-13 Identities = 85/341 (24%), Positives = 146/341 (42%), Gaps = 56/341 (16%) Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437 E+L RE L A+ ++K + + + + G ++ + AE Q + Q + D A L Sbjct: 1482 EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD----EASL 1537 Query: 438 DELRRQREDTE-KAQRSLSEIERKA---QANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493 ++++Q D E K + E++ +A Q EQ +L+ + + Q H+ + E Sbjct: 1538 AKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV 1597 Query: 494 KQVSMA-----RQAQVDLE----------REKKELEDSLERISDQGQRKTQEQLE----- 533 ++ + +Q +V LE REK+ELE L +SDQ R+ E + Sbjct: 1598 EEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKD 1657 Query: 534 -------------VLESLKQELATSQRELQVLQGSLETS-------AQSEANWAAEFAEL 573 +L+ LK A S+RE+ L+ LE S ++ E +L Sbjct: 1658 LKRTKALLADAQLMLDHLKNS-APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716 Query: 574 EKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633 + D + EE+LS L++E + Q +L +E M +L K + + SR A+ Sbjct: 1717 HLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ- 1775 Query: 634 VIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKS 674 I D QLEE L + ++ S +E LE+S Sbjct: 1776 -INDLQAQLEE-----ANKEKQELQEKLQALQSQVEFLEQS 1810 Score = 69.3 bits (168), Expect = 2e-11 Identities = 61/283 (21%), Positives = 134/283 (47%), Gaps = 17/283 (6%) Query: 361 NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTE--SQRVVLQLKGHVSELEADLAE 418 +F S+ + KD ++R ++ + L+++K S+R + QLK + E E A Sbjct: 1647 DFESEKRLRKD-----LKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAA 1701 Query: 419 QQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSEL 478 R+ + E L ++D++ + + E+ LS ++R+ + R + +E +EL Sbjct: 1702 AVKARKAMEVEIEDLHLQIDDIAKAKTALEE---QLSRLQREKNEIQNRLEEDQEDMNEL 1758 Query: 479 VQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538 ++ H + + + Q++ + + +EK+EL++ L+ + Q Q + EQ V +SL Sbjct: 1759 MKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL--QSQVEFLEQSMVDKSL 1816 Query: 539 KQELATSQRELQVLQGSLETSAQSEANWAAEFAE----LEKERDSLVSGAAHREEELSAL 594 REL+ T + + A+ E L +ERD ++ +E+ L Sbjct: 1817 VSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRL 1876 Query: 595 RKELQDTQLKLASTEESMCQLAKDQRKMLL-VGSRKAAEQVIQ 636 +++L+DT+ ++ + ++ + ++ + + S +AA Q +Q Sbjct: 1877 QRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919 Score = 62.8 bits (151), Expect = 2e-09 Identities = 67/261 (25%), Positives = 116/261 (44%), Gaps = 25/261 (9%) Query: 378 ERLYREISGLKAQL----ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL 433 ER RE+ K +L E+ Q+ QL+ + +L+AD E Q QQ C+ L Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRL 1435 Query: 434 RAELDELRRQRE-------DTEKAQR----SLSEIERKAQANEQRYSKLKEKYSELVQNH 482 AEL + + E + EK QR LS+ +AQ + + KL+ + L+ Sbjct: 1436 TAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEA 1495 Query: 483 ADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQEL 542 L ++ E ++ Q V LE E +++ S E + K ++QL LE+ ++ Sbjct: 1496 FSLKQQLEEKDMDIAGFTQKVVSLEAELQDI-SSQESKDEASLAKVKKQLRDLEA---KV 1551 Query: 543 ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ 602 + EL G+++ Q++ E+E+ R + R+EE+ R Q Q Sbjct: 1552 KDQEEELDEQAGTIQMLEQAKLRLE---MEMERMRQTHSKEMESRDEEVEEAR---QSCQ 1605 Query: 603 LKLASTEESMCQLAKDQRKML 623 KL E + + +D++K+L Sbjct: 1606 KKLKQMEVQLEEEYEDKQKVL 1626 Score = 52.8 bits (125), Expect = 2e-06 Identities = 54/235 (22%), Positives = 107/235 (45%), Gaps = 20/235 (8%) Query: 383 EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442 +I+ K LE + QR +++ + E + D+ E + A A++++L+ Sbjct: 1722 DIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQA 1781 Query: 443 QREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQA 502 Q E+ K ++ L E K QA L+ + L Q+ D + V++Q + R+ Sbjct: 1782 QLEEANKEKQELQE---KLQA-------LQSQVEFLEQSMVD----KSLVSRQEAKIREL 1827 Query: 503 QVDLEREK---KELEDSLERISDQGQRKTQEQLEVLESLKQELATS---QRELQVLQGSL 556 + LE E+ K LE R+ + ++ T+E+ + + + +E + QR+L+ + + Sbjct: 1828 ETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEM 1887 Query: 557 ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEES 611 A+ EA + + ELE + +SL + + +L K + D Q + ES Sbjct: 1888 GELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMES 1942 Score = 49.3 bits (116), Expect = 2e-05 Identities = 135/695 (19%), Positives = 253/695 (36%), Gaps = 124/695 (17%) Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490 E +R + +E+++ R EKA++ +E+ + E R S+L SEL R Sbjct: 1254 EQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELT---SELTDE-----RNTG 1305 Query: 491 EVTKQVSMARQAQ-VDLEREKKELEDSLERISDQGQRKTQEQLEVLES------------ 537 E Q+ A A+ + E+E KEL+ + + Q + ++EV+E+ Sbjct: 1306 ESASQLLDAETAERLRAEKEMKELQTQYDALKKQME---VMEMEVMEARLIRAAEINGEV 1362 Query: 538 ----------LKQELA------TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLV 581 LK E A T +R Q + LE Q++ +L+ + + Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQ 1422 Query: 582 SGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM---LLVGSRKAAEQVIQDA 638 +++ L ELQDT+L L + +L K QR+ L +A + +Q Sbjct: 1423 RALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQRE 1482 Query: 639 LNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698 Q E+ D LL+ S+ +E+ + + + + L I+ Sbjct: 1483 KLQREK----------DMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532 Query: 699 TSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADST------- 751 ++A + D E +Q G + A L E +E T Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMES 1592 Query: 752 -------AMRNCLSKIKAIGEEL------------LPRGLDIKQEELGDLVD-------- 784 A ++C K+K + +L R L+ K L D V+ Sbjct: 1593 RDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEK 1652 Query: 785 ---KEMAATSAAIETATARIEEML----SKSRAGDTGVKLEVNERILGCCTSLMQAIQVL 837 K++ T A + A ++ + SK +LE +E C + ++A + + Sbjct: 1653 RLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESE---FTCAAAVKARKAM 1709 Query: 838 IVASKDLQREIVESGRGTASPKEFYAKNSR---------------WTEGLISASKAVGWG 882 V +DL +I + + + +E ++ R E + AV Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1769 Query: 883 ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGV 942 + + DL Q +E ++ A +Q+ + DK +L Q+A + Sbjct: 1770 SRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDK---SLVSRQEAK--I 1824 Query: 943 NQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLE----LENELQKER 998 + + K + + LT+ + Q + ++ R E L+ +L+ + Sbjct: 1825 RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1884 Query: 999 QKLGELRKKHYELAGVAEGWE---EGTEASPPTLQ 1030 +++GEL +K E + E E EA+ +LQ Sbjct: 1885 EEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919 >gi|28416946 myosin 18A isoform a [Homo sapiens] Length = 2054 Score = 75.1 bits (183), Expect = 3e-13 Identities = 85/341 (24%), Positives = 146/341 (42%), Gaps = 56/341 (16%) Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437 E+L RE L A+ ++K + + + + G ++ + AE Q + Q + D A L Sbjct: 1482 EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD----EASL 1537 Query: 438 DELRRQREDTE-KAQRSLSEIERKA---QANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493 ++++Q D E K + E++ +A Q EQ +L+ + + Q H+ + E Sbjct: 1538 AKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV 1597 Query: 494 KQVSMA-----RQAQVDLE----------REKKELEDSLERISDQGQRKTQEQLE----- 533 ++ + +Q +V LE REK+ELE L +SDQ R+ E + Sbjct: 1598 EEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKD 1657 Query: 534 -------------VLESLKQELATSQRELQVLQGSLETS-------AQSEANWAAEFAEL 573 +L+ LK A S+RE+ L+ LE S ++ E +L Sbjct: 1658 LKRTKALLADAQLMLDHLKNS-APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716 Query: 574 EKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQ 633 + D + EE+LS L++E + Q +L +E M +L K + + SR A+ Sbjct: 1717 HLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ- 1775 Query: 634 VIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKS 674 I D QLEE L + ++ S +E LE+S Sbjct: 1776 -INDLQAQLEE-----ANKEKQELQEKLQALQSQVEFLEQS 1810 Score = 69.3 bits (168), Expect = 2e-11 Identities = 61/283 (21%), Positives = 134/283 (47%), Gaps = 17/283 (6%) Query: 361 NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTE--SQRVVLQLKGHVSELEADLAE 418 +F S+ + KD ++R ++ + L+++K S+R + QLK + E E A Sbjct: 1647 DFESEKRLRKD-----LKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAA 1701 Query: 419 QQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSEL 478 R+ + E L ++D++ + + E+ LS ++R+ + R + +E +EL Sbjct: 1702 AVKARKAMEVEIEDLHLQIDDIAKAKTALEE---QLSRLQREKNEIQNRLEEDQEDMNEL 1758 Query: 479 VQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538 ++ H + + + Q++ + + +EK+EL++ L+ + Q Q + EQ V +SL Sbjct: 1759 MKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL--QSQVEFLEQSMVDKSL 1816 Query: 539 KQELATSQRELQVLQGSLETSAQSEANWAAEFAE----LEKERDSLVSGAAHREEELSAL 594 REL+ T + + A+ E L +ERD ++ +E+ L Sbjct: 1817 VSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRL 1876 Query: 595 RKELQDTQLKLASTEESMCQLAKDQRKMLL-VGSRKAAEQVIQ 636 +++L+DT+ ++ + ++ + ++ + + S +AA Q +Q Sbjct: 1877 QRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919 Score = 62.8 bits (151), Expect = 2e-09 Identities = 67/261 (25%), Positives = 116/261 (44%), Gaps = 25/261 (9%) Query: 378 ERLYREISGLKAQL----ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL 433 ER RE+ K +L E+ Q+ QL+ + +L+AD E Q QQ C+ L Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRL 1435 Query: 434 RAELDELRRQRE-------DTEKAQR----SLSEIERKAQANEQRYSKLKEKYSELVQNH 482 AEL + + E + EK QR LS+ +AQ + + KL+ + L+ Sbjct: 1436 TAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEA 1495 Query: 483 ADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQEL 542 L ++ E ++ Q V LE E +++ S E + K ++QL LE+ ++ Sbjct: 1496 FSLKQQLEEKDMDIAGFTQKVVSLEAELQDI-SSQESKDEASLAKVKKQLRDLEA---KV 1551 Query: 543 ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ 602 + EL G+++ Q++ E+E+ R + R+EE+ R Q Q Sbjct: 1552 KDQEEELDEQAGTIQMLEQAKLRLE---MEMERMRQTHSKEMESRDEEVEEAR---QSCQ 1605 Query: 603 LKLASTEESMCQLAKDQRKML 623 KL E + + +D++K+L Sbjct: 1606 KKLKQMEVQLEEEYEDKQKVL 1626 Score = 52.8 bits (125), Expect = 2e-06 Identities = 54/235 (22%), Positives = 107/235 (45%), Gaps = 20/235 (8%) Query: 383 EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442 +I+ K LE + QR +++ + E + D+ E + A A++++L+ Sbjct: 1722 DIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQA 1781 Query: 443 QREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQA 502 Q E+ K ++ L E K QA L+ + L Q+ D + V++Q + R+ Sbjct: 1782 QLEEANKEKQELQE---KLQA-------LQSQVEFLEQSMVD----KSLVSRQEAKIREL 1827 Query: 503 QVDLEREK---KELEDSLERISDQGQRKTQEQLEVLESLKQELATS---QRELQVLQGSL 556 + LE E+ K LE R+ + ++ T+E+ + + + +E + QR+L+ + + Sbjct: 1828 ETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEM 1887 Query: 557 ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEES 611 A+ EA + + ELE + +SL + + +L K + D Q + ES Sbjct: 1888 GELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMES 1942 Score = 49.3 bits (116), Expect = 2e-05 Identities = 135/695 (19%), Positives = 253/695 (36%), Gaps = 124/695 (17%) Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490 E +R + +E+++ R EKA++ +E+ + E R S+L SEL R Sbjct: 1254 EQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELT---SELTDE-----RNTG 1305 Query: 491 EVTKQVSMARQAQ-VDLEREKKELEDSLERISDQGQRKTQEQLEVLES------------ 537 E Q+ A A+ + E+E KEL+ + + Q + ++EV+E+ Sbjct: 1306 ESASQLLDAETAERLRAEKEMKELQTQYDALKKQME---VMEMEVMEARLIRAAEINGEV 1362 Query: 538 ----------LKQELA------TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLV 581 LK E A T +R Q + LE Q++ +L+ + + Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQ 1422 Query: 582 SGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM---LLVGSRKAAEQVIQDA 638 +++ L ELQDT+L L + +L K QR+ L +A + +Q Sbjct: 1423 RALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQRE 1482 Query: 639 LNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698 Q E+ D LL+ S+ +E+ + + + + L I+ Sbjct: 1483 KLQREK----------DMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532 Query: 699 TSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADST------- 751 ++A + D E +Q G + A L E +E T Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMES 1592 Query: 752 -------AMRNCLSKIKAIGEEL------------LPRGLDIKQEELGDLVD-------- 784 A ++C K+K + +L R L+ K L D V+ Sbjct: 1593 RDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEK 1652 Query: 785 ---KEMAATSAAIETATARIEEML----SKSRAGDTGVKLEVNERILGCCTSLMQAIQVL 837 K++ T A + A ++ + SK +LE +E C + ++A + + Sbjct: 1653 RLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESE---FTCAAAVKARKAM 1709 Query: 838 IVASKDLQREIVESGRGTASPKEFYAKNSR---------------WTEGLISASKAVGWG 882 V +DL +I + + + +E ++ R E + AV Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1769 Query: 883 ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGV 942 + + DL Q +E ++ A +Q+ + DK +L Q+A + Sbjct: 1770 SRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDK---SLVSRQEAK--I 1824 Query: 943 NQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLE----LENELQKER 998 + + K + + LT+ + Q + ++ R E L+ +L+ + Sbjct: 1825 RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1884 Query: 999 QKLGELRKKHYELAGVAEGWE---EGTEASPPTLQ 1030 +++GEL +K E + E E EA+ +LQ Sbjct: 1885 EEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919 >gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] Length = 1498 Score = 75.1 bits (183), Expect = 3e-13 Identities = 140/651 (21%), Positives = 262/651 (40%), Gaps = 86/651 (13%) Query: 373 KDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEF 432 KD+ + L ++++ L++QL+ ++ E + +LK +E+ + + +Q +QQ A E Sbjct: 529 KDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEA 588 Query: 433 ---LRAELDELR--RQREDTEKAQRSLSEIERKAQANEQRYSKLKEK---YSELVQNHAD 484 L+ E+ ++ + + L + Q E ++ +KEK ++L AD Sbjct: 589 RVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEAD 648 Query: 485 LLRKNAEVTKQVSMARQAQVDLEREKKELE---DSLERISDQGQRKTQEQLEV------- 534 +L + A + + DL+R +E E + L+R++D Q+ +V Sbjct: 649 MLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQR 708 Query: 535 ---LESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEEL 591 LE+L+QE ++L + Q +L++ QS + EL+ L AA RE+ + Sbjct: 709 DQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI 768 Query: 592 SALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAE--QVIQDALNQLEEPPLIS 649 L+ E E+ Q AK ++ L G+R+ E + + L +L E I Sbjct: 769 CLLQNE--------KIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIK 820 Query: 650 CAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATT 709 +G +HL ++ +Q++K Q+L + T L S+ Sbjct: 821 -SGQVEHLQQETAALK---KQMQKIKEQFLQQKVMVEAYRRDATSKDQLISE-------- 868 Query: 710 CLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLP 769 L+A + DS + +Q + + E E S + + +R ++ ++ + Sbjct: 869 -LKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQK 927 Query: 770 RGLDIKQEELGDLVDKE-MAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCT 828 +++ DKE M A + A E +IEE+ ++R T K ++ R LG Sbjct: 928 ERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKM--RRLG--- 982 Query: 829 SLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTE--GLISASKAVGWGATVM 886 DL T++ KE K+ + G++S A Sbjct: 983 -------------SDL----------TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEA 1019 Query: 887 VDAADLVVQGRGKFEELMVCSHE-IAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQA 945 DA ++ +G + + HE I A A+L A S K + + S+ + + Sbjct: 1020 ADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEE- 1078 Query: 946 TAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQK 996 S + +E D + S +IKR E ++ LELE+E K Sbjct: 1079 ---------SREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGK 1120 Score = 47.4 bits (111), Expect = 7e-05 Identities = 140/630 (22%), Positives = 233/630 (36%), Gaps = 88/630 (13%) Query: 296 PNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSF 355 P+ + S S V+ + SPD++ LE L S+ + D+ + S+ Sbjct: 266 PDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSDSSS-YSSAS 324 Query: 356 SSDPFNFNSQNGVNKDEK-----DHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVS 410 + + S+ +D + + +K L+ E Q ++ G V Sbjct: 325 TRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVR 384 Query: 411 E----------LEADLAEQQHLRQQAADDCEFLRAELDELRRQREDT--EKA--QRSLSE 456 LE+ AE Q Q + L +L+ L + EKA Q L+ Sbjct: 385 SRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAA 444 Query: 457 IERKAQA-------NEQRYSKLKEKYSELVQNHADLLR-----KNAEVTKQVSMARQAQV 504 + K QA ++QR L + L Q+ DL R +N K S+A + Sbjct: 445 LSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLA-SSNN 503 Query: 505 DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEA 564 DL+ +++ + + ++ D QR + + L+Q++ Q +LQ +Q T Sbjct: 504 DLQVAEEQYQRLMAKVEDM-QRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLK 562 Query: 565 NWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ------------LKLASTEESM 612 AE + L+ R A +E L+ E+ Q LKL + S Sbjct: 563 ASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQ 622 Query: 613 CQLAKDQRKMLLVGSRKAAE---------------QVIQDALNQLEEP---PLISCAGSA 654 QL + Q + + R AA+ IQ+A +EE L G Sbjct: 623 -QLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGER 681 Query: 655 DHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHS-ITLLAHLTSDAIAHGATTCLRA 713 + L S +S +QLE+ L + + L + L+ LT A L++ Sbjct: 682 ERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEA------LQS 735 Query: 714 PPEPADSL----TEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLP 769 + D+L E + G E AS E+ L + + L K+ G+E L Sbjct: 736 REQSLDALQTHYDELQARLG-ELQGEAASREDTICLLQNEKIILEAALQAAKS-GKEELD 793 Query: 770 RG---LDIKQEELGDLVDK---EMAATSAAIE---TATARIEEMLSKSRAGDTGVKLEVN 820 RG L+ EE + ++K E+A S +E TA +++ + K + K+ V Sbjct: 794 RGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMV- 852 Query: 821 ERILGCCTSLMQAIQVLIVASKDLQREIVE 850 E TS Q I L K L E+ E Sbjct: 853 EAYRRDATSKDQLISELKATRKRLDSELKE 882 Score = 47.0 bits (110), Expect = 9e-05 Identities = 63/284 (22%), Positives = 126/284 (44%), Gaps = 38/284 (13%) Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQL---KGHVSEL-EADLAEQ 419 SQ EK +E +E G + +++ ++ ++++ L+L KG ++ L +++ A + Sbjct: 1073 SQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALR 1132 Query: 420 QH-------LRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLK 472 +H L ++ AD + L ++ + +++E+ ++ + L QA + K K Sbjct: 1133 EHNSILETALAKREADLVQ-LNLQVQAVLQRKEEEDRQMKHL------VQALQASLEKEK 1185 Query: 473 EKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELE------DSLERISDQGQR 526 EK + L + A E + A ++L KKEL+ L+ +D Q Sbjct: 1186 EKVNSLKEQVA---AAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI 1242 Query: 527 KTQEQLEVLESLKQELATSQRELQVLQGSLE-------TSAQSEANWAAEFAELEKERDS 579 + + + + + ELA ++ +LQ+LQ L+ Q N E + E+E S Sbjct: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302 Query: 580 LVSGAAHREE----ELSALRKELQDTQLKLASTEESMCQLAKDQ 619 L E+ EL L++ LQ+ + +L +E + KD+ Sbjct: 1303 LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDK 1346 Score = 45.1 bits (105), Expect = 4e-04 Identities = 56/273 (20%), Positives = 118/273 (43%), Gaps = 36/273 (13%) Query: 380 LYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE 439 L+ I L+A+L+ + + +L+ ++ +L E + + D+ + R + Sbjct: 1040 LHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKK 1099 Query: 440 LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYS----ELVQNHADLLRKNAEVTKQ 495 ++R E +K L + K Q + L+E S L + ADL++ N +V Q Sbjct: 1100 IKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQV--Q 1157 Query: 496 VSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGS 555 + R+ + D R+ K L +L Q +++ E + SLK+++A ++ E Sbjct: 1158 AVLQRKEEED--RQMKHLVQAL-------QASLEKEKEKVNSLKEQVAAAKVE------- 1201 Query: 556 LETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQL 615 + + ++ A EL + + L + +E + L+ E D Q++ + + Q Sbjct: 1202 ---AGHNRRHFKAASLELSEVKKELQA----KEHLVQKLQAEADDLQIREGKHSQEIAQF 1254 Query: 616 AKDQRKMLLVGSRKAAEQVIQDALN-QLEEPPL 647 + + +A Q++Q L+ QL + P+ Sbjct: 1255 QAE------LAEARAQLQLLQKQLDEQLSKQPV 1281 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 73.9 bits (180), Expect = 7e-13 Identities = 126/672 (18%), Positives = 259/672 (38%), Gaps = 96/672 (14%) Query: 369 NKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAAD 428 N ++ +E +E++ L+ +K ES+ +L V EL A ++E LR + A+ Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280 Query: 429 DCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRK 488 L+ ELD + E+ EK + + A + E + +E E + +L + Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKG---IKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337 Query: 489 NAEVTKQVSMARQAQVDLEREKKELEDSLERISDQ---GQRKTQEQLEVLESLKQELATS 545 ++ ++ + ++ Q + E +K LE + + Q ++K + L +ESL++ Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397 Query: 546 QRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKL 605 ++ + L LE A + L++E D L H+ + S L K+ Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK-------- 1449 Query: 606 ASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSIS 665 ++ QL +++ + +R A E+ +A + +E +S A + + L Sbjct: 1450 ---QKKFDQLLAEEKS---ISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFE 1503 Query: 666 SCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEAC 725 +QL ++ +D+ +H + + A Sbjct: 1504 RQNKQLRADMEDLMSSKDDVGKNVHEL--------------------------EKSKRAL 1537 Query: 726 KQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDK 785 +Q E L LE+E + + +KA E L + D + EE L+ K Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL-QTRDEQNEEKKRLLIK 1596 Query: 786 EMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN--------ERILGCCTSLMQAIQVL 837 ++ A +E +E ++ A + K+E++ E +++ ++ L Sbjct: 1597 QVRELEAELE------DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL 1650 Query: 838 IVASKDLQREIVESGRGTASPKEFYAKNS--------------RWTEGLISASKAVGWGA 883 KD QRE+ E+ AS E +A++ + E L S+ +A Sbjct: 1651 QAQMKDYQRELEEA---RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE 1707 Query: 884 TVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVN 943 + AD + L+ + A AQL + + +++ N+ L R Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQL----EEELEEEQSNMELLNDRFRKTT 1763 Query: 944 QATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKE------ 997 + A + +S +++DN Q++RQ + + ++ ELE ++ + Sbjct: 1764 LQVDTLNAELAAERSAAQKSDN------ARQQLERQNKELKAKLQELEGAVKSKFKATIS 1817 Query: 998 --RQKLGELRKK 1007 K+G+L ++ Sbjct: 1818 ALEAKIGQLEEQ 1829 Score = 63.5 bits (153), Expect = 1e-09 Identities = 133/679 (19%), Positives = 269/679 (39%), Gaps = 95/679 (13%) Query: 384 ISGLKAQL---ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDEL 440 IS L+ +L E + E ++ +L G ++L+ +AE L+A++DEL Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE--------------LQAQIDEL 1081 Query: 441 RRQ-REDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMA 499 + Q + E+ Q +L+ + + ++E +++ + D + A K Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141 Query: 500 RQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETS 559 R +LE K ELED+L+ + Q + +T+ + EV E LK+ L + E + + ++ Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE-LKKAL---EEETKNHEAQIQDM 1197 Query: 560 AQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQ 619 Q A E +E ++ + ++ L KEL + E + Q K + Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL--------ACEVKVLQQVKAE 1249 Query: 620 RKMLLVGSRKAAEQVIQDALNQLEEPP--LISCAGSADHLLSTVTSISSCIEQLEKSWSQ 677 + RK + +Q+ ++ E + A A L + + ++S+ +E+ EK + Sbjct: 1250 SE----HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305 Query: 678 YLACPEDI-SGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSL-------TEACKQYG 729 + + S L + LL T + ++ +R E +SL EA K Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKL--NLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363 Query: 730 RETLAYLASL--------EEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGD 781 ++ LA + L ++ G++E+ + A + L +A+ + L Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEE-AKKKLLKDAEALSQRL-------------- 1408 Query: 782 LVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVAS 841 +E A +E R+++ L D V L+ ++ + L+ Sbjct: 1409 ---EEKALAYDKLEKTKNRLQQELD-----DLTVDLDHQRQVASNLEKKQKKFDQLLAEE 1460 Query: 842 KDLQ-REIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF 900 K + R E R A +E K +S ++A+ + Q R Sbjct: 1461 KSISARYAEERDRAEAEAREKETK-------ALSLARALEEALEAKEEFERQNKQLRADM 1513 Query: 901 EELMVCSHEIAASTAQLVAASKV---KADKDSPNLAQLQQASRGVNQATAGVVASTISGK 957 E+LM ++ + +L + + + ++ L +L+ + A + + + K Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573 Query: 958 SQIE-ETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAE 1016 +Q E + D + + K++ + QVR LE E E +++++ L KK E+ + Sbjct: 1574 AQFERDLQTRDEQN----EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID--LK 1627 Query: 1017 GWEEGTEASPPTLQEVVTE 1035 E EA+ EV+ + Sbjct: 1628 DLEAQIEAANKARDEVIKQ 1646 Score = 62.4 bits (150), Expect = 2e-09 Identities = 92/443 (20%), Positives = 177/443 (39%), Gaps = 32/443 (7%) Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDC 430 D+ + RL +E+ L L++ + +V L+ + + LAE++ + + A++ Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQR----QVASNLEKKQKKFDQLLAEEKSISARYAEER 1471 Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490 + AE RE KA +E +A E+ + + +L + DL+ Sbjct: 1472 DRAEAEA------REKETKALSLARALEEALEAKEE----FERQNKQLRADMEDLMSSKD 1521 Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQ 550 +V K V +++ LE++ +E+ LE + D+ Q +L + +++ A +R+LQ Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581 Query: 551 VLQGSLETSAQSEANWAAEF-AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609 E + E AELE ER A +++ + +L+D + ++ + Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK----MEIDLKDLEAQIEAAN 1637 Query: 610 ESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIE 669 ++ ++ K RK L K ++ +++A +E S L S I E Sbjct: 1638 KARDEVIKQLRK--LQAQMKDYQRELEEARASRDEI-FAQSKESEKKLKSLEAEILQLQE 1694 Query: 670 QLEKSWSQYLACPEDISGLLHSITLLAHLTSDAI-----AHGATTCLRAPPEPADSLTEA 724 +L S ++ L IT A S + L E S E Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754 Query: 725 CKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD 784 R+T + +L E + E + + N +++ +EL K +EL V Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL-----KAKLQELEGAVK 1809 Query: 785 KEMAATSAAIETATARIEEMLSK 807 + AT +A+E ++EE L + Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQ 1832 Score = 57.0 bits (136), Expect = 9e-08 Identities = 112/576 (19%), Positives = 224/576 (38%), Gaps = 69/576 (11%) Query: 439 ELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSM 498 ++ RQ E+ + L +++ K E +++ K+ +L++ L + T+ + Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905 Query: 499 ARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATS----QRELQVLQG 554 A + + L +K+ELE+ L + + + + +E+ ++L++ K+++ + +L +G Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEE-EERNQILQNEKKKMQAHIQDLEEQLDEEEG 964 Query: 555 SLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQ 614 + + + A+ ++E+E L + +E + + + +LA EE Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024 Query: 615 LAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKS 674 LAK + K ++ S ++ Q E G L + + + I++L+ Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK-- 1082 Query: 675 WSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLA 734 Q E++ G A+A G L A K RE A Sbjct: 1083 -LQLAKKEEELQG--------------ALARGDDETLHK--------NNALKVV-RELQA 1118 Query: 735 YLASLEEEGSLENADSTAMRNCLSKIKA-IGEELLPRGLDIKQEELGDLVDKEMAATSAA 793 +A L+E+ E A RN K K + EE L+ + EL D +D T+A Sbjct: 1119 QIAELQEDFESEKAS----RNKAEKQKRDLSEE-----LEALKTELEDTLD----TTAAQ 1165 Query: 794 IETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGR 853 E T R +E+ +A + E + Q A ++L ++ ++ Sbjct: 1166 QELRTKREQEVAELKKA--------LEEETKNHEAQIQDMRQRHATALEELSEQLEQA-- 1215 Query: 854 GTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAAS 913 K F A + +GL + +K + V+ R K + + H + Sbjct: 1216 -----KRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSE 1270 Query: 914 TAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTL 973 +L KA K L + + S +SQ+++T + L Sbjct: 1271 GDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL------L 1324 Query: 974 TQIKRQEMDSQVRVLELE---NELQKERQKLGELRK 1006 + RQ+++ R+ +LE N LQ+++++ E RK Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360 Score = 57.0 bits (136), Expect = 9e-08 Identities = 143/756 (18%), Positives = 311/756 (41%), Gaps = 99/756 (13%) Query: 331 DLMDMDASQQNLFDNKFDDIFGSSFSSDPFNF------NSQNGVNKDEKDHLIERLYREI 384 +L +M+ Q L + K +I ++ F ++ K E + ++ L + Sbjct: 874 ELEEMERKHQQLLEEK--NILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV 931 Query: 385 SGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQR 444 + + + ++ E ++ ++ H+ +LE L E++ RQ+ E + AE ++++ Sbjct: 932 EEEEERNQILQNEKKK----MQAHIQDLEEQLDEEEGARQKL--QLEKVTAEA-KIKKME 984 Query: 445 EDTEKAQRSLSEIERKAQANEQRYSKLKEKYS---ELVQNHADLLRKN----AEVTKQVS 497 E+ + S+ ++ + E R ++ + + E +N A + K +++ +++ Sbjct: 985 EEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK 1044 Query: 498 MARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQ--VLQGS 555 + + +LE+ K++L+ + DQ E ++ LK +LA + ELQ + +G Sbjct: 1045 KEEKTRQELEKAKRKLDGETTDLQDQ----IAELQAQIDELKLQLAKKEEELQGALARGD 1100 Query: 556 LETSAQSEA-----NWAAEFAELEKERDSLVSGAAHRE-------EELSALRKELQDTQL 603 ET ++ A A+ AEL+++ +S + E EEL AL+ EL+DT Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160 Query: 604 KLASTEESMCQLAKD--QRKMLLVGSRKAAEQVIQD-------ALNQLEEPPLISCAGSA 654 A+ +E + ++ + K L K E IQD AL +L E + A Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKA 1220 Query: 655 D-----HLLSTVTSISSC---IEQLEKSWSQYLACPEDIS-GLLHSITLLAHLTSDAIAH 705 + L T +C + Q K+ S++ D LH+ +A Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280 Query: 706 GATTCLRAPPEPADSLTEACK---QYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKA 762 A+ + L EA K ++ ++ + + L++ L ++ N S+I+ Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340 Query: 763 IGEELLPRGLDIKQEELGDL---VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV 819 + EE L +QEE + ++K++ A + + ++++ L + + E Sbjct: 1341 LEEE--KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE-----EA 1393 Query: 820 NERILGCCTSLMQAIQVLIVA-------SKDLQREI------VESGRGTASPKEFYAKNS 866 +++L +L Q ++ +A LQ+E+ ++ R AS E K Sbjct: 1394 KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE---KKQ 1450 Query: 867 RWTEGLISASKAVGWGATVMVDAADLVVQGR--------GKFEELMVCSHEIAASTAQLV 918 + + L++ K++ D A+ + + EE + E QL Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510 Query: 919 A-ASKVKADKD--SPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQ 975 A + + KD N+ +L+++ R + Q + + +++ T++ Q Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570 Query: 976 IKRQEMDSQVRVLELENELQKERQKLGELRKKHYEL 1011 + + + ++ + +NE +K+R + ++R+ EL Sbjct: 1571 AMKAQFERDLQTRDEQNE-EKKRLLIKQVRELEAEL 1605 Score = 46.2 bits (108), Expect = 2e-04 Identities = 55/279 (19%), Positives = 118/279 (42%), Gaps = 41/279 (14%) Query: 370 KDEKDHLIERLYREISGLKAQLENMKT----------ESQRVVLQLKGHVSELEADLAEQ 419 +DE + +L ++ + +LE + ES++ + L+ + +L+ +LA Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699 Query: 420 QHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELV 479 + R+ A E DEL + ++ + +L + +R+ +A R ++L+E+ E Sbjct: 1700 ERARRHAEQ-------ERDELADEITNSASGKSALLDEKRRLEA---RIAQLEEELEEEQ 1749 Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE-SL 538 N L + + T QV A++ ER + D+ + ++ ++ + +L+ LE ++ Sbjct: 1750 SNMELLNDRFRKTTLQVDTLN-AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808 Query: 539 KQELATSQRELQVLQGSLETSAQSEANWAAE---------------FAELEKERDSLVSG 583 K + + L+ G LE + EA A F ++E ER Sbjct: 1809 KSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER----RH 1864 Query: 584 AAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM 622 A +E++ ++ + +L EE + +RK+ Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903 Score = 39.3 bits (90), Expect = 0.019 Identities = 50/209 (23%), Positives = 93/209 (44%), Gaps = 31/209 (14%) Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431 + D+ ++L R+ LKA+L+ ++ V + K +S LEA + + + +Q A + Sbjct: 1782 KSDNARQQLERQNKELKAKLQELEGA---VKSKFKATISALEAKIGQLEEQLEQEAKE-- 1836 Query: 432 FLRAELDELRRQREDTEKAQRSLSEI-----------ERKAQANEQRYSKLKEKYSELVQ 480 RA ++L R+ E + L EI ++ + E+ +++K+ +L + Sbjct: 1837 --RAAANKLVRRTE------KKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE 1888 Query: 481 NHADLLRKNA---EVTKQVSMARQAQVDLEREKKELEDSLER---ISDQGQRKTQEQLEV 534 + R NA ++ +++ A +A L RE L++ L R IS R + QL Sbjct: 1889 AEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLH- 1947 Query: 535 LESLKQELATSQRELQVLQGSLETSAQSE 563 LE EL+ E + + QSE Sbjct: 1948 LEGASLELSDDDTESKTSDVNETQPPQSE 1976 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 73.6 bits (179), Expect = 9e-13 Identities = 125/705 (17%), Positives = 260/705 (36%), Gaps = 82/705 (11%) Query: 328 EKDDLMDMDASQQNLFDNKFDD--IFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREIS 385 E +D +D A+QQ L + + I + + +Q + + +E L ++ Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206 Query: 386 G---LKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRR 442 +KA LE K + +L V L + +H R++ + L+ + +E R Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266 Query: 443 QRED----TEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSM 498 R + K Q L + ++ + SKL + +S L D E +Q Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326 Query: 499 ARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLET 558 +E EK + LE ++ + ++Q+ L + ++A +++++ G LET Sbjct: 1327 LSTKLKQVEDEKNSFREQLEE-EEEAKHNLEKQIATLHA---QVADMKKKMEDSVGCLET 1382 Query: 559 SAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKD 618 + + + + L + + V+ E+ + L++EL D + L +S C L K Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442 Query: 619 QRKM-------LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQL 671 Q+K + ++ A E+ +A + +E +S A + + + + +Q Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQF 1502 Query: 672 EKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRE 731 ++ +D+ +H + + A +Q E Sbjct: 1503 RTEMEDLMSSKDDVGKSVHEL--------------------------EKSKRALEQQVEE 1536 Query: 732 TLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATS 791 L LE+E + L +KA E L +G D + EE + +++ Sbjct: 1537 MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDL-QGRDEQSEEKKKQLVRQVREME 1595 Query: 792 AAIETATARIEEMLSKSRAGDTGVKLEVNERILGC--------CTSLMQAIQVLIVASKD 843 A +E +E +S A KLE++ + L ++ ++ L KD Sbjct: 1596 AELE------DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649 Query: 844 LQRE-----------IVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADL 892 RE + ++ K A+ + E L +A +A + AD Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709 Query: 893 VVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVAS 952 + GK + + A AQL + + +++ N + + N + Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQL----EEELEEEQGNTELINDRLKKANLQIDQINTD 1765 Query: 953 TISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKE 997 +S ++ +N Q++RQ + +V++ E+E ++ + Sbjct: 1766 LNLERSHAQKNEN------ARQQLERQNKELKVKLQEMEGTVKSK 1804 Score = 70.5 bits (171), Expect = 8e-12 Identities = 132/669 (19%), Positives = 265/669 (39%), Gaps = 81/669 (12%) Query: 366 NGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425 N ++EK + +L + + LE ++ +L+ +LE D + L Q Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD---LSDQ 1063 Query: 426 AADDCEFLRAELDELRRQ-REDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD 484 A+ L+A++ EL+ Q + E+ Q +L+ +E +A K++E S++ + D Sbjct: 1064 IAE----LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119 Query: 485 LLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELAT 544 L + A K R +LE K ELED+L+ + Q + +++ Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR-------------- 1165 Query: 545 SQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLK 604 ++E+ +L+ +LE A++ A+ E+ ++ V A + E+ ++ L+ + Sbjct: 1166 -EQEVNILKKTLEEEAKTH---EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221 Query: 605 LASTEESMCQLAKDQRKMLLVG------SRKAAEQVIQDALNQLEEPPLISCAGSADHLL 658 L E +LA ++ K+LL G RK E +Q+ + E + AD + Sbjct: 1222 L---ENERGELA-NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR-TELADKVT 1276 Query: 659 STVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPA 718 + + L +S S+ +D S L ++ L+ Sbjct: 1277 KLQVELDNVTGLLSQSDSKSSKLTKDFSAL------------ESQLQDTQELLQEENRQK 1324 Query: 719 DSLTEACKQYGRETLAYLASLEEE----GSLENADSTAMRNCLSKIKAIGEEL--LPRGL 772 SL+ KQ E ++ LEEE +LE +T K + + + L Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384 Query: 773 DIKQEELGDLV-----DKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCC 827 ++K++ DL +E A +E R+++ L D V L+ + Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD-----DLLVDLDHQRQSACNL 1439 Query: 828 TSLMQAIQVLIVASKDLQREIVES-GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVM 886 + L+ K + + E R A +E K +S ++A+ Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETK-------ALSLARALEEAMEQK 1492 Query: 887 VDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKV---KADKDSPNLAQLQQASRGVN 943 + L Q R + E+LM ++ S +L + + + ++ L +L+ + Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552 Query: 944 QATAGVVASTISGKSQIE-ETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLG 1002 A + + + K+Q E + D S + K++++ QVR +E E E +++++ + Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQS----EEKKKQLVRQVREMEAELEDERKQRSMA 1608 Query: 1003 ELRKKHYEL 1011 +K E+ Sbjct: 1609 VAARKKLEM 1617 Score = 60.8 bits (146), Expect = 6e-09 Identities = 115/501 (22%), Positives = 210/501 (41%), Gaps = 89/501 (17%) Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVV--LQLKGHVS-ELEADLA--EQQHLRQQ 425 +E++ L ++I+ L AQ+ +MK + + V L+ V +L+ DL Q+H + Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV 1405 Query: 426 AADDCEFLRAELDELRRQRE------DTEKAQRSLSEIERKAQANEQRYSKLKE---KYS 476 AA D + E + R Q+E D + ++S +E+K + +Q ++ K KY+ Sbjct: 1406 AAYD----KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYA 1461 Query: 477 ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE 536 E ++ A+ + E TK +S+AR + +E++ + LER++ Q + ++E L Sbjct: 1462 E-ERDRAEAEAREKE-TKALSLARALEEAMEQKAE-----LERLNKQ----FRTEMEDLM 1510 Query: 537 SLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRK 596 S K ++ S EL+ + +LE Q + ELE E + E L A++ Sbjct: 1511 SSKDDVGKSVHELEKSKRALE---QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567 Query: 597 ELQ-DTQLKLASTEESMCQLAKDQRKM------------LLVGSRKAAEQVIQDALNQLE 643 + + D Q + +EE QL + R+M + V +RK E ++D Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDL----- 1622 Query: 644 EPPLISCAGSADHLLSTVTSISS----CIEQLEK---SWSQYLACPEDISGLLHSITLLA 696 E + S + D + + + + C+ +L+ S + LA ++ L S+ Sbjct: 1623 EAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM 1682 Query: 697 HLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAY---------LASLEEEGSLEN 747 + +A +A E + E G+ LA +A LEEE E Sbjct: 1683 IQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ 1742 Query: 748 ADSTAMRNCLSK----IKAIGEEL-LPRG------------------LDIKQEELGDLVD 784 ++ + + L K I I +L L R L +K +E+ V Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK 1802 Query: 785 KEMAATSAAIETATARIEEML 805 + A+ A+E A++EE L Sbjct: 1803 SKYKASITALEAKIAQLEEQL 1823 Score = 58.2 bits (139), Expect = 4e-08 Identities = 138/646 (21%), Positives = 253/646 (39%), Gaps = 98/646 (15%) Query: 392 ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR-RQREDTEKA 450 EN TE + + QL +AE+ L++Q + E L AE +ELR R ++ Sbjct: 865 ENRLTEMETLQSQL----------MAEKLQLQEQLQAETE-LCAEAEELRARLTAKKQEL 913 Query: 451 QRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREK 510 + ++E + + E+R L+ + ++ QN E+ +Q+ A+ L+ EK Sbjct: 914 EEICHDLEARVEEEEERCQHLQAEKKKMQQN-------IQELEEQLEEEESARQKLQLEK 966 Query: 511 KELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEF 570 E L +K +E+ +LE +LA ++ L+ T+ E + Sbjct: 967 VTTEAKL--------KKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL 1018 Query: 571 AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMC-QLAKDQRKMLLVGSRK 629 A+L+ + +++++ R R+EL+ T+ KL + Q+A+ Q ++ + + Sbjct: 1019 AKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078 Query: 630 A-AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC------- 681 A E+ +Q AL ++EE A + L + + S I +L++ A Sbjct: 1079 AKKEEELQAALARVEEE-----AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133 Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741 D+ L ++ T D+ A A LR+ E +E +LEE Sbjct: 1134 KRDLGEELEALKTELEDTLDSTA--AQQELRSKRE-------------QEVNILKKTLEE 1178 Query: 742 EGSLENADSTAMRNCLSK-IKAIGEEL---------LPRGLDIKQEELGDLVD--KEMAA 789 E A MR S+ ++ + E+L L + + E G+L + K + Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238 Query: 790 TSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIV 849 E ++E L + + VK ER+ T L + L V ++ + Sbjct: 1239 GKGDSEHKRKKVEAQLQELQ-----VKFNEGERVR---TELADKVTKLQVELDNVTGLLS 1290 Query: 850 ES-GRGTASPKEFYAKNSRW--TEGLISASKAVGWG-ATVMVDAADLVVQGRGKFEELMV 905 +S + + K+F A S+ T+ L+ +T + D R + EE Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE 1350 Query: 906 CSHEIAASTAQL---VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962 H + A L VA K K + L ++ R + + + G SQ E Sbjct: 1351 AKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQK--------DLEGLSQRHE 1402 Query: 963 TDNMDFSSMTLTQIK-RQEMDSQVRVLELENELQKERQKLGELRKK 1007 + + T+ + +QE+D +L +L +RQ L KK Sbjct: 1403 EKVAAYDKLEKTKTRLQQELD------DLLVDLDHQRQSACNLEKK 1442 Score = 55.8 bits (133), Expect = 2e-07 Identities = 122/593 (20%), Positives = 239/593 (40%), Gaps = 96/593 (16%) Query: 439 ELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSM 498 ++ RQ E+ + L ++ K A E R ++++ S+L+ L + T+ + Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898 Query: 499 ARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLET 558 A + + L +K+ELE+ I + + +E+ E + L+ E Q+ +Q L+ LE Sbjct: 899 AEELRARLTAKKQELEE----ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE- 953 Query: 559 SAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKD 618 E A + +LEK A K+L++ Q+ L E+ C+LAK+ Sbjct: 954 ----EEESARQKLQLEK-------------VTTEAKLKKLEEEQIIL---EDQNCKLAKE 993 Query: 619 QRKMLLVGSRKAAEQVIQDALNQL--EEPPLISCAGSADHLLSTVTSISSCIEQLEKSWS 676 +K E I + L EE S A + + +T + + + EK Sbjct: 994 ---------KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQ 1044 Query: 677 QYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYL 736 + + G + SD IA L+A + A+ + K+ E A L Sbjct: 1045 ELEKTRRKLEGDSTDL-------SDQIAE-----LQA--QIAELKMQLAKK-EEELQAAL 1089 Query: 737 ASLEEEGSLENADSTAMRNCLSKIKAIGEEL-LPRGLDIKQEELGDLVDKEMAATSAAIE 795 A +EEE + +N +R S+I + E+L R K E+ + +E+ A +E Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE 1149 Query: 796 ---TATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESG 852 +TA +E+ SK +K + E + + Q A ++L ++ ++ Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209 Query: 853 RGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG-----------KFE 901 R A+ L A + + + + +++QG+G + + Sbjct: 1210 RVKAN--------------LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255 Query: 902 ELMVCSHE---IAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958 EL V +E + A V +V+ D + L+Q S + + + + +S Sbjct: 1256 ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL-------ES 1308 Query: 959 QIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYEL 1011 Q+++T + L + RQ++ ++ ++E+E R++L E + + L Sbjct: 1309 QLQDTQEL------LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355 >gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo sapiens] Length = 1939 Score = 72.8 bits (177), Expect = 2e-12 Identities = 103/510 (20%), Positives = 215/510 (42%), Gaps = 71/510 (13%) Query: 369 NKDEKDHLIERLYREISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLRQQ 425 +K + D +++ E+SGL++++E+ + + Q+ + +L+ + ELE ++ ++ R + Sbjct: 1076 DKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAK 1135 Query: 426 AADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485 A L EL+E+ + E+ A + E+ +K +A Q+ + E+ + + A Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1195 Query: 486 LRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRKTQEQLEV 534 LRK AE+ +Q+ ++ + LE+EK E++ ++ ++ + + ++ Sbjct: 1196 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRA 1255 Query: 535 LESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHREEE 590 LE E+ T + E Q L L + E++ E+D+LVS G ++ Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315 Query: 591 LSALRKELQD---TQLKLASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQVIQ- 636 + L+++L++ + LA +S C L ++Q + L KA +V Q Sbjct: 1316 IEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQW 1375 Query: 637 ------DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLH 690 DA+ + EE + L + +E + + + + + Sbjct: 1376 RTKYETDAIQRTEE-----LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVE 1430 Query: 691 SITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEG------- 743 + + T+ A A L D + KQ ET A L + ++E Sbjct: 1431 DLMIDVERTNAACA-----ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485 Query: 744 -SLENADSTAM----------RNCLSKIKAIGEELLPRGLDIKQ-EELGDLVDKEMAATS 791 ++NA ++ +N +I + E++ G I + E++ V++E + Sbjct: 1486 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ 1545 Query: 792 AAIETATARIEEMLSKSRAGDTGVKLEVNE 821 AA+E A A +E K ++LE+N+ Sbjct: 1546 AALEEAEASLEHEEGKI----LRIQLELNQ 1571 Score = 57.4 bits (137), Expect = 7e-08 Identities = 87/425 (20%), Positives = 185/425 (43%), Gaps = 45/425 (10%) Query: 390 QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEK 449 QL K + + + ++ + E AE +++ D+C L+ ++D+L Sbjct: 911 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL--------- 961 Query: 450 AQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLERE 509 + +L+++E++ A E + L E+ + L + A L ++ K + A Q +D + Sbjct: 962 -ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK----KALQEAHQQTLD---D 1013 Query: 510 KKELEDSLERISDQGQRKTQEQLEVLE-SLKQELATS---QRELQVLQGSLETSAQSEAN 565 + ED + ++ + + K ++Q++ LE SL+QE +R + L+G L+ + +S + Sbjct: 1014 LQAEEDKVNTLT-KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMD 1072 Query: 566 WAAEFAELE---KERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM 622 + +L+ K+++ +SG + E+ AL +LQ +L + E + + + +R Sbjct: 1073 IENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAER-- 1130 Query: 623 LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682 SR AE+ D +LEE ++ L + S+ IE +K +++ Sbjct: 1131 ---ASRAKAEKQRSDLSRELEE--------ISERLEEAGGATSAQIEMNKKREAEFQKMR 1179 Query: 683 EDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEE 742 D L TL T+ + + E D+L ++ +E +++ Sbjct: 1180 RD----LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1235 Query: 743 GSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIE 802 S S A N +A+ ++L + K+EE L++ ++ A A ++T + Sbjct: 1236 ASNMETVSKAKGNLEKMCRALEDQL--SEIKTKEEEQQRLIN-DLTAQRARLQTESGEYS 1292 Query: 803 EMLSK 807 L + Sbjct: 1293 RQLDE 1297 Score = 55.5 bits (132), Expect = 3e-07 Identities = 146/671 (21%), Positives = 260/671 (38%), Gaps = 70/671 (10%) Query: 387 LKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRED 446 + A+L K + + +LK + +LE LA+ + + + + L E+ L Sbjct: 936 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 995 Query: 447 TEKAQRSLSEIERKA----QANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQA 502 K +++L E ++ QA E + + L + +L Q D L + E K++ M Sbjct: 996 LTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ-QVDDLEGSLEQEKKIRM---- 1050 Query: 503 QVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETS--- 559 DLER K++LE L+ Q T + + L ++L + E+ LQ +E Sbjct: 1051 --DLERAKRKLEGDLK----LAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQAL 1104 Query: 560 ----AQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQL 615 + A ELE+E ++ + A E++ S L +EL++ +L E Sbjct: 1105 GMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL----EEAGGA 1160 Query: 616 AKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSW 675 Q +M K E Q LEE L A +A S++ EQ++ Sbjct: 1161 TSAQIEM-----NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1215 Query: 676 SQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAY 735 ++ S + I D +A T +A +L + C+ + L+ Sbjct: 1216 RVKQKLEKEKSEMKMEI--------DDLASNMETVSKA----KGNLEKMCRAL-EDQLSE 1262 Query: 736 LASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIE 795 + + EEE D TA R L GE R LD K + L + A T IE Sbjct: 1263 IKTKEEEQQRLINDLTAQRARLQ--TESGE--YSRQLDEKDTLVSQLSRGKQAFTQ-QIE 1317 Query: 796 TATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGT 855 ++EE + A ++ ++ C L + + A +LQR + ++ Sbjct: 1318 ELKRQLEEEIKAKSALAHALQSSRHD-----CDLLREQYEEEQEAKAELQRAMSKANSEV 1372 Query: 856 ASPKEFYAKNS-RWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAAST 914 A + Y ++ + TE L A K + A + DA + V K L + Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKL---AQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429 Query: 915 AQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFS-SMTL 973 L+ + ++ + A L + R ++ A +++E + S S L Sbjct: 1430 EDLM----IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485 Query: 974 TQIKR--QEMDSQVRVLELENE-LQKE----RQKLGELRKKHYELAGVAEGWEEGTEASP 1026 +IK +E Q+ L+ EN+ LQ+E +++ E K+ +EL + + E+ Sbjct: 1486 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ 1545 Query: 1027 PTLQEVVTEKE 1037 L+E E Sbjct: 1546 AALEEAEASLE 1556 Score = 52.4 bits (124), Expect = 2e-06 Identities = 121/603 (20%), Positives = 227/603 (37%), Gaps = 66/603 (10%) Query: 460 KAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLER 519 K+ E+ + +KE++ + + A K E+ +++ Q + DL+ + + DSL Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904 Query: 520 ISDQGQR--KTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKER 577 ++ + KT+ QLE E A + E+ + + + E +EL+K+ Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC------SELKKDI 958 Query: 578 DSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637 D L A E+E A ++++ ++A +E++ +L K+++ + ++A +Q + D Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDD 1013 Query: 638 ALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAH 697 Q EE + + + L V + +EQ +K + G + L Sbjct: 1014 L--QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG---DLKLAQE 1068 Query: 698 LTSD------------AIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745 T D + L++ E +L ++ +E A + LEEE Sbjct: 1069 STMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEA 1128 Query: 746 ENADSTAMRNCLSKIKAIGEELLPR-----GLDIKQEELGDLVDKEMAATSAAIETATAR 800 E A S + EE+ R G Q E+ + E +E AT + Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188 Query: 801 IEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKE 860 E + R E+ E+I +L + Q L +++ EI + AS E Sbjct: 1189 HEATAATLRKKHADSVAELGEQI----DNLQRVKQKLEKEKSEMKMEIDD----LASNME 1240 Query: 861 FYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAA 920 + SKA G + D + + + K EE +++ A A+L Sbjct: 1241 -------------TVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTE 1287 Query: 921 SKVKADKDSPNLAQLQQASRGVNQATAGV------VASTISGKSQIEETDNMDFSSMTLT 974 S + + + Q SRG T + + I KS + + S Sbjct: 1288 SGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHA--LQSSRHDCD 1345 Query: 975 QIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVT 1034 ++ Q + Q EL+ + K ++ + R K YE + + EE EA Q + Sbjct: 1346 LLREQYEEEQEAKAELQRAMSKANSEVAQWRTK-YETDAI-QRTEELEEAKKKLAQRLQD 1403 Query: 1035 EKE 1037 +E Sbjct: 1404 AEE 1406 Score = 50.4 bits (119), Expect = 8e-06 Identities = 120/666 (18%), Positives = 258/666 (38%), Gaps = 92/666 (13%) Query: 417 AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSL----SEIERKAQANEQRYSKLK 472 AE + ++ E + EL + +R++ E+ +L ++++ + QA + + Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAE 906 Query: 473 EKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL 532 E+ +L++ L K EVT++ + +L +K++LED + Sbjct: 907 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD--------- 957 Query: 533 EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELS 592 ++ L+ LA ++E + ++ + A A+L KE+ +L ++L Sbjct: 958 --IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015 Query: 593 A------------LRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN 640 A ++ E Q L+ + +E ++ ++ K L G K A++ D N Sbjct: 1016 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEN 1075 Query: 641 ---QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAH 697 QL+E L L S + + QL+K + A E++ + A Sbjct: 1076 DKQQLDE-KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIE-----AE 1129 Query: 698 LTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLE-------------EEGS 744 S A A + L + ++E ++ G T A + + EE + Sbjct: 1130 RASRAKAEKQRSDL---SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1186 Query: 745 L--ENADSTAMRNCLSKIKAIGEEL-----LPRGLDIKQEELGDLVDKEMAATSAAIETA 797 L E +T + + +GE++ + + L+ ++ E+ +D ++A+ + A Sbjct: 1187 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-DLASNMETVSKA 1245 Query: 798 TARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES---- 851 +E+M + + + K E +R++ T+ +Q S + R++ E Sbjct: 1246 KGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQ---TESGEYSRQLDEKDTLV 1302 Query: 852 ---GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSH 908 RG + + + R E I A A+ DL+ R ++EE Sbjct: 1303 SQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLL---REQYEEEQEAKA 1359 Query: 909 EIAASTAQL---VAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEETD 964 E+ + ++ VA + K + D+ +L++A + +A + + E Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQDAEEHVEAV 1411 Query: 965 NMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEA 1024 N +S+ T +Q + ++V +L ++++ L KK + W++ E Sbjct: 1412 NAKCASLEKT---KQRLQNEVE--DLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEE 1466 Query: 1025 SPPTLQ 1030 + L+ Sbjct: 1467 THAELE 1472 Score = 48.1 bits (113), Expect = 4e-05 Identities = 76/363 (20%), Positives = 154/363 (42%), Gaps = 52/363 (14%) Query: 370 KDEKDHLIERLY---REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426 ++ K L +RL + + A+ +++ QR+ +++ + ++E A L ++ Sbjct: 1391 EEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQ 1450 Query: 427 ADDCEFL---RAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELV 479 + + L + + +E + E ++K RSLS +I+ + + + LK + L Sbjct: 1451 RNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQ 1510 Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE--------------------- 518 Q +DL + AE K++ + + +E+EK EL+ +LE Sbjct: 1511 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELN 1570 Query: 519 RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFA 571 ++ + RK E+ E ++ +K+ R ++ +Q +L+ +S + + Sbjct: 1571 QVKSEVDRKIAEKDEEIDQMKR---NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1627 Query: 572 ELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLAKDQRKMLLVGS 627 E+E + + AA + L+DTQL L S E+ QLA +R+ L+ + Sbjct: 1628 EMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQA 1687 Query: 628 -----RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682 R EQ + ++ E L+ + L + TS+ + ++LE SQ Sbjct: 1688 EIEELRATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEM 1745 Query: 683 EDI 685 EDI Sbjct: 1746 EDI 1748 Score = 42.0 bits (97), Expect = 0.003 Identities = 43/236 (18%), Positives = 104/236 (44%), Gaps = 12/236 (5%) Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441 +E+ +++ + T++ ++ K +++ E + + Q+A + E + + + Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAA 1767 Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501 E+ +K Q + + +ER + EQ L+ + E Q L ++ K + R+ Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ--LALKGGKKQIQKLEARVRE 1825 Query: 502 AQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSL----- 556 + ++E E+K ++++ + + +RK +E E ++ + Q + LQ + Sbjct: 1826 LEGEVESEQKRNVEAVKGLR-KHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKR 1884 Query: 557 ---ETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609 E QS N ++F ++ E + A E +++ LR + ++ K+ S E Sbjct: 1885 QAEEAEEQSNVN-LSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939 >gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo sapiens] Length = 1939 Score = 72.4 bits (176), Expect = 2e-12 Identities = 114/518 (22%), Positives = 216/518 (41%), Gaps = 86/518 (16%) Query: 370 KDEKDHLIERLYR---EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLR 423 +++K L E+L + E+S L+ ++E+ + + Q+ + +L+ + ELE ++ ++ R Sbjct: 1074 ENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASR 1133 Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483 +A L EL+E+ + E+ A + E+ +K +A Q+ + E+ + + A Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATA 1193 Query: 484 DLLRKN-----AEVTKQVSMARQAQVDLEREKKELE-------DSLERISDQGQRKTQEQ 531 LRK AE+ +Q+ ++ + LE+EK EL+ ++E +S + + ++ Sbjct: 1194 AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVS-KAKANFEKM 1252 Query: 532 LEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHR 587 LE E+ T + E Q L L + EF+ E+D++VS G Sbjct: 1253 CRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAF 1312 Query: 588 EEELSALRKEL-QDTQLK--LASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQV 634 +++ L+++L ++T+ K LA +S C L ++Q + L G KA +V Sbjct: 1313 TQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEV 1372 Query: 635 IQ-------DALNQLE--EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685 Q DA+ + E E A V +++S LEK+ + ED+ Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDL 1432 Query: 686 SGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745 + ++ A L D + KQ ET A L + ++E Sbjct: 1433 ------------MIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKE--- 1477 Query: 746 ENADSTAMRNCLSKIKAIGEELLPRGLDIK------QEELGDL----------------V 783 S ++ L K+K EE L +K Q+E+ DL V Sbjct: 1478 ----SRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKV 1533 Query: 784 DKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNE 821 K++ + ++T+ E L ++LE+N+ Sbjct: 1534 KKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQ 1571 Score = 63.2 bits (152), Expect = 1e-09 Identities = 60/296 (20%), Positives = 135/296 (45%), Gaps = 30/296 (10%) Query: 379 RLYREISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRA 435 +L +++ L+ LE K + +R +L+G + + + ++ +QQ + + Sbjct: 1030 KLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEF 1089 Query: 436 ELDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAE 491 E+ L+ + ED + + Q+ + E++ + + E+ + ++ + +DL R+ E Sbjct: 1090 EMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149 Query: 492 VTK-----------QVSMARQAQVDLEREKKELEDS----------LERISDQGQRKTQE 530 +++ Q+ M ++ + + ++ +++LE+S L + + E Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209 Query: 531 QLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEE 590 Q++ L+ +KQ+L + EL++ L ++ ++ + A F ++ + + +S +EEE Sbjct: 1210 QIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEE 1269 Query: 591 LSALRKEL--QDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644 L EL Q +L S E S KD L ++A Q I++ QLEE Sbjct: 1270 QQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEE 1325 Score = 62.4 bits (150), Expect = 2e-09 Identities = 75/312 (24%), Positives = 144/312 (46%), Gaps = 44/312 (14%) Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQH----LRQQ 425 K + DH L + +A LE+ + + R+ L+L SE++ +AE+ L++ Sbjct: 1534 KKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRN 1593 Query: 426 AADDCEFLRAELDELRRQREDT----EKAQRSLSEIERKAQ-ANEQRYSKLKEKYSEL-- 478 E +++ LD R R D +K + L+E+E + AN Q L+ + Sbjct: 1594 HLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGI 1653 Query: 479 ---VQNHAD-LLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL-- 532 Q H D +R ++ +Q++M + ++ E +EL SLER +++G++ +++L Sbjct: 1654 LKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLER-TERGRKMAEQELLD 1712 Query: 533 -----EVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFA------------ 571 ++L + L ++++L+ +QG +E Q EA A E A Sbjct: 1713 ASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQ-EARNAEEKAKKAITDAAMMAE 1771 Query: 572 ELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAA 631 EL+KE+D+ +AH E + + ++D QL+L E+ + K Q + L R+ Sbjct: 1772 ELKKEQDT----SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1827 Query: 632 EQVIQDALNQLE 643 +V + + +E Sbjct: 1828 SEVESEQKHNVE 1839 Score = 57.0 bits (136), Expect = 9e-08 Identities = 117/563 (20%), Positives = 210/563 (37%), Gaps = 66/563 (11%) Query: 460 KAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLER 519 K+ E+ + +KE++ + + A K E+ +++ Q + DL+ + + D+L Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904 Query: 520 ISDQGQR--KTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKER 577 ++ + KT+ QLE E A + E+ + + + E +EL+K+ Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC------SELKKDI 958 Query: 578 DSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637 D L A E+E A ++++ ++A +E++ +L K+++ + ++A +Q + D Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDD 1013 Query: 638 ALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAH 697 Q+EE + + + L V + +EQ +K + G + L Sbjct: 1014 L--QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEG---DLKLAQE 1068 Query: 698 LTSDA------------IAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745 T D + L+ E +L ++ +E A + LEEE Sbjct: 1069 STMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEA 1128 Query: 746 ENADSTAMRNCLSKIKAIGEELLPR-----GLDIKQEELGDLVDKEMAATSAAIETATAR 800 E A S + EE+ R G Q E+ + E +E +T + Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQ 1188 Query: 801 IEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREI--VESGRGTAS- 857 E + R E+ E+I SL + Q L +L+ EI + S T S Sbjct: 1189 HEATAAALRKKHADSVAELGEQI----DSLQRVKQKLEKEKSELKMEINDLASNMETVSK 1244 Query: 858 PKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQL 917 K + K R E +S K K EE +E++A A+L Sbjct: 1245 AKANFEKMCRTLEDQLSEIKT--------------------KEEEQQRLINELSAQKARL 1284 Query: 918 VAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIK 977 S + + A + Q SRG T + K Q+EE + Q Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEEL----KRQLEEETKAKSTLAHALQSA 1340 Query: 978 RQEMDSQVRVLELENELQKERQK 1000 R + D E E E + E Q+ Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQR 1363 Score = 57.0 bits (136), Expect = 9e-08 Identities = 89/428 (20%), Positives = 179/428 (41%), Gaps = 45/428 (10%) Query: 390 QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEK 449 QL K + + + ++ + E AE +++ D+C L+ ++D+L Sbjct: 911 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL--------- 961 Query: 450 AQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLERE 509 + +L+++E++ A E + L E+ + L + A L ++ K + A Q +D Sbjct: 962 -ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK----KALQEAHQQTLD---- 1012 Query: 510 KKELEDSLERISDQGQRKTQEQLEVLE-SLKQE---LATSQRELQVLQGSLETSAQS--- 562 ++E+ + + K ++Q++ LE SL+QE +R + L+G L+ + +S Sbjct: 1013 DLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMD 1072 Query: 563 EANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKM 622 N + E K+++ +S + E+ AL +LQ +L + E + + + +R Sbjct: 1073 TENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAER-- 1130 Query: 623 LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682 SR AE+ D +LEE ++ L + S+ IE +K +++ Sbjct: 1131 ---ASRAKAEKQRSDLSRELEE--------ISERLEEAGGATSAQIEMNKKREAEFQKMR 1179 Query: 683 EDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEE 742 D L TL T+ A+ + E DSL ++ +E + + Sbjct: 1180 RD----LEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDL 1235 Query: 743 GSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIE 802 S S A N + + ++L + K+EE L++ E++A A + T + Sbjct: 1236 ASNMETVSKAKANFEKMCRTLEDQL--SEIKTKEEEQQRLIN-ELSAQKARLHTESGEFS 1292 Query: 803 EMLSKSRA 810 L + A Sbjct: 1293 RQLDEKDA 1300 Score = 52.4 bits (124), Expect = 2e-06 Identities = 65/289 (22%), Positives = 129/289 (44%), Gaps = 55/289 (19%) Query: 387 LKAQLENMKTESQRVVLQLKGHVSELEADLA---EQQHLRQQAADDCEFLRAELDE---- 439 + A+L K + + +LK + +LE LA +++H + + A LDE Sbjct: 936 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 995 Query: 440 LRRQREDTEKA-QRSLSEI---ERKAQANEQRYSKLKEKYSELVQN-------HADLLRK 488 L ++++ ++A Q++L ++ E K + +KL+++ +L + DL R Sbjct: 996 LTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA 1055 Query: 489 NAEVTKQVSMARQAQVDLEREKKELEDSLER-----------------ISDQGQRKTQEQ 531 ++ + +A+++ +D E +K++L + L++ ++ Q Q+K +E Sbjct: 1056 KRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKEL 1115 Query: 532 LEVLESLKQELATSQ--------------RELQVLQGSLE-----TSAQSEANWAAEFAE 572 +E L++E+ + REL+ + LE TSAQ E N E AE Sbjct: 1116 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE-AE 1174 Query: 573 LEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRK 621 +K R L E +ALRK+ D+ +L +S+ ++ + K Sbjct: 1175 FQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEK 1223 Score = 48.5 bits (114), Expect = 3e-05 Identities = 74/358 (20%), Positives = 154/358 (43%), Gaps = 53/358 (14%) Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429 +D ++H +E + + + L+ + ++ E + +++ ++ + A +Q++ + A+ Sbjct: 1402 QDAEEH-VEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAE- 1459 Query: 430 CEFLRAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELVQNHADL 485 + + +E + + E ++K RSLS +++ + + LK + L Q +DL Sbjct: 1460 ---WKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDL 1516 Query: 486 LRKNAEVTKQVSMARQAQVDLEREKKELEDSLE---------------------RISDQG 524 + AE K + + + L+ EK EL+ SLE ++ + Sbjct: 1517 TEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576 Query: 525 QRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFAELEKER 577 RK E+ E L+ LK+ R ++ +Q +L+ +S + + E+E + Sbjct: 1577 DRKIAEKDEELDQLKR---NHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQL 1633 Query: 578 DSLVSGAAHREEELSALRKELQDTQLKL----ASTEESMCQLAKDQRKMLLVGSRKAAEQ 633 + AA L + L+DTQL L ++ QLA +R+ L+ +A + Sbjct: 1634 NHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLM---QAEVE 1690 Query: 634 VIQDALNQLE------EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685 ++ +L + E E L+ + L + TS+ + ++LE SQ EDI Sbjct: 1691 ELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748 Score = 47.8 bits (112), Expect = 5e-05 Identities = 46/244 (18%), Positives = 102/244 (41%), Gaps = 27/244 (11%) Query: 417 AEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSL----SEIERKAQANEQRYSKLK 472 AE + ++ E + EL + +R++ E+ +L ++++ + QA + + Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAE 906 Query: 473 EKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL 532 E+ +L++ L K EVT++ + +L +K++LED + Sbjct: 907 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD--------- 957 Query: 533 EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSL-------VSGAA 585 ++ L+ LA ++E + ++ + A A+L KE+ +L + Sbjct: 958 --IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015 Query: 586 HREEELSALRKELQDTQLKLASTEESMCQLAK-----DQRKMLLVGSRKAAEQVIQDALN 640 E++++ L K + ++ E S+ Q K ++ K L G K A++ D N Sbjct: 1016 MEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEN 1075 Query: 641 QLEE 644 ++ Sbjct: 1076 DKQQ 1079 Score = 41.2 bits (95), Expect = 0.005 Identities = 88/501 (17%), Positives = 194/501 (38%), Gaps = 44/501 (8%) Query: 559 SAQSEANWAAEFAELEKERDSLVSGAAHR---EEELSALRKELQDTQLKLASTEESMCQL 615 SA++E A E EK ++ L A R EE++ L +E D QL++ + +++ Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADA 905 Query: 616 AKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSW 675 ++R L+ ++ E I++ + E+ I+ +A +LE Sbjct: 906 --EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK------------RKLEDEC 951 Query: 676 SQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTE---ACKQYGRET 732 S+ +D+ L + H T + + + T + E LT+ A ++ ++T Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKN-LTEEMAGLDETIAKLTKEKKALQEAHQQT 1010 Query: 733 LAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSA 792 L L E++ + T + + ++ E+ +D+++ + D ++A S Sbjct: 1011 LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQEST 1070 Query: 793 A-IETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES 851 E ++ E L K + ++ ++ + L + I+ L ++L+ EI Sbjct: 1071 MDTENDKQQLNEKLKKKEFEMSNLQGKIEDE-QALAIQLQKKIKELQARIEELEEEIEAE 1129 Query: 852 GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIA 911 A ++ + SR E + + G + ++ + + E ++ Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE------MNKKREAEFQKMRRDLE 1183 Query: 912 ASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEE-TDNMDFSS 970 ST Q A + K + ++A+L + + + + K +I + NM+ S Sbjct: 1184 ESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVS 1243 Query: 971 MT--------------LTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAE 1016 L++IK +E + Q + EL + + + GE ++ E + Sbjct: 1244 KAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVS 1303 Query: 1017 GWEEGTEASPPTLQEVVTEKE 1037 G +A ++E+ + E Sbjct: 1304 QLSRGKQAFTQQIEELKRQLE 1324 >gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo sapiens] Length = 1983 Score = 72.0 bits (175), Expect = 3e-12 Identities = 132/695 (18%), Positives = 292/695 (42%), Gaps = 73/695 (10%) Query: 379 RLYREISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRA 435 RL +++ L+ LE ++ +++R +L+G + + +A+ +QQ + + + Sbjct: 1075 RLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDS 1134 Query: 436 ELDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAE 491 EL +L + ED + + Q+ + E++ +A+ E+ + + + + A+ R+ E Sbjct: 1135 ELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEE 1194 Query: 492 VTKQVSMA-----------RQAQVDLEREKKELED----------SLERISDQGQRKTQE 530 +++++ A R+ + +L R ++ELE+ +L R +G + E Sbjct: 1195 LSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGE 1254 Query: 531 QLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEE 590 Q++ L+ ++Q+L + EL++ L + ++ A +L + + +S A + EE Sbjct: 1255 QVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE 1314 Query: 591 LSALRKELQDTQLKLASTEESMCQLAKDQRKML--LVGSRKAAEQVIQDALNQLEEPPLI 648 L + + +L + + +L +++ ++ L + A Q +++ QLEE Sbjct: 1315 LQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEE--- 1371 Query: 649 SCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGAT 708 S A SA L V ++ + L + + ++ LL A+ Sbjct: 1372 SKAKSA--LAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK------------ANAEV 1417 Query: 709 TCLRAPPEPADSL--TEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEE 766 R+ E AD++ TE ++ ++ L EE NA +++ +++ E+ Sbjct: 1418 AQWRSKYE-ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESED 1476 Query: 767 LLPRGLDIKQ-EELGDLVDKEMAATSAAIETATARIEEM---LSKSRAGDTGVKLEVNER 822 + L++++ +DK+ A+E + EEM L ++ G+ E+ R Sbjct: 1477 VT---LELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTEL-FR 1532 Query: 823 ILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWG 882 + ++A++ L +K+LQ EI + + + + + + L KA+ G Sbjct: 1533 LRHGHEEALEALETLKRENKNLQEEI-------SDLTDQVSLSGKSIQELEKTKKALE-G 1584 Query: 883 ATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKV-KADKDSPNLAQLQQASRG 941 + AA +G + EE ++ S + K+ + D++ NL + Q R Sbjct: 1585 EKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQ--RA 1642 Query: 942 VNQATAGVVASTISGKSQIEETDNMDFS----SMTLTQIKRQEMDSQVRVLELENELQKE 997 V A + A T + + M+ + L RQ ++Q ++ +L++E Sbjct: 1643 VESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEE 1702 Query: 998 RQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEV 1032 + E ++ EL A+ E L+E+ Sbjct: 1703 QAGRDEEQRLAAELHEQAQALERRASLLAAELEEL 1737 Score = 71.2 bits (173), Expect = 5e-12 Identities = 84/328 (25%), Positives = 147/328 (44%), Gaps = 29/328 (8%) Query: 370 KDEKDHLIERLY-REISGLKAQLE---NMKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425 KDE+ + R + R + L+A L+ + E+ R+ +++G +++LE L H +Q Sbjct: 1628 KDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLG---HATRQ 1684 Query: 426 AADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSEL--VQNHA 483 A + R +L+ ++ ++ QR +E+ +AQA E+R S L + EL Sbjct: 1685 ATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQG 1744 Query: 484 DLLRKNAE-----VTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538 + R+ AE T+++++ L +KK+LE L ++S + + QE+ E E Sbjct: 1745 ERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKA 1804 Query: 539 KQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR--EEELSALRK 596 K+ + + + L+ +TSA E ++K + V R E E +ALR Sbjct: 1805 KKAITDAAMMAEELKKEQDTSAHLE--------RMKKTLEQTVRELQARLEEAEQAALRG 1856 Query: 597 ELQDTQLKLASTEESMCQLAKDQRK--MLLVGSRKAAEQVIQDALNQLEE--PPLISCAG 652 + Q A E +L +Q+K L G RK E+ +++ Q EE L Sbjct: 1857 GKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRK-HERRVKELAYQAEEDRKNLARMQD 1915 Query: 653 SADHLLSTVTSISSCIEQLEKSWSQYLA 680 D L S V S E+ E+ + LA Sbjct: 1916 LVDKLQSKVKSYKRQFEEAEQQANTNLA 1943 Score = 67.4 bits (163), Expect = 7e-11 Identities = 140/653 (21%), Positives = 254/653 (38%), Gaps = 100/653 (15%) Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436 +E L R+++ Q ++TES EL L E++ L Q + Sbjct: 1312 VEELQRQLADASTQRGRLQTES-----------GELSRLLEEKECLISQLSRGKALAAQS 1360 Query: 437 LDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR----KNAEV 492 L+ELRRQ E+ KA+ +L+ QA L+E++ E + A+L R NAEV Sbjct: 1361 LEELRRQLEEESKAKSALA---HAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEV 1417 Query: 493 ----TKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRE 548 +K + A Q +LE KK+L L+ +++G + LE K L T + Sbjct: 1418 AQWRSKYEADAIQRTEELEEAKKKLALRLQE-AEEGVEAANAKCSSLEKAKLRLQTESED 1476 Query: 549 LQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAST 608 + L+ TSA A L+K++ L R + +++EL+ Q + Sbjct: 1477 V-TLELERATSAA---------AALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGL 1526 Query: 609 EESMCQLAKDQRKML-LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSC 667 + +L + L + + K + +Q+ ++ L + +S +G ++ + Sbjct: 1527 GTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQ--VSLSG------KSIQELEKT 1578 Query: 668 IEQLEKSWSQYLACPEDISGLL---HSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEA 724 + LE S+ A E+ G L + TL L + L E +L Sbjct: 1579 KKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLR-- 1636 Query: 725 CKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD 784 + + R + ASL+ E T RN L +K++ GDL D Sbjct: 1637 -RNHQRAVESLQASLDAE--------TRARN--------------EALRLKKKMEGDLND 1673 Query: 785 KEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQ---VLIVAS 841 E+ A + A+ L +++ + + +R+ QA++ L+ A Sbjct: 1674 LELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAE 1733 Query: 842 KDLQREIVESGRGT--ASPKEFYAKNSR------WTEGLISASKAVGWGATVMVDAADLV 893 + R +E G + + +E R GL++ K + + + Sbjct: 1734 LEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEA 1793 Query: 894 VQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVAST 953 Q R + EE A T + A ++K ++D+ A L++ + + Q + Sbjct: 1794 AQERREAEE-----KAKKAITDAAMMAEELKKEQDTS--AHLERMKKTLEQTVREL---- 1842 Query: 954 ISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRK 1006 ++++EE + L K+Q + +V ELE EL E++K E K Sbjct: 1843 ---QARLEEAE-----QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALK 1887 Score = 65.5 bits (158), Expect = 3e-10 Identities = 146/678 (21%), Positives = 284/678 (41%), Gaps = 114/678 (16%) Query: 387 LKAQLENMKTESQRVVL------QLKGHVSELEADLAEQQHL-------RQQAADDCEFL 433 L+A+ +N+ +R L QL+G V EL L +++ + R++ D+C L Sbjct: 940 LQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTEL 999 Query: 434 RAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVT 493 + ++D+L+ +L++ E++ QA E + L E+ + L ++ A L ++ + Sbjct: 1000 KKDIDDLK----------LTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ 1049 Query: 494 KQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE-SLKQE---LATSQREL 549 + +QA DL+ E ED + ++ + + + ++Q+E LE SL+QE ++R Sbjct: 1050 E---AHQQALGDLQAE----EDRVSALT-KAKLRLEQQVEDLECSLEQEKKLRMDTERAK 1101 Query: 550 QVLQGSLETSAQSEANWAAEFAELE---KERDSLVSGAAHREEELSAL----RKELQDTQ 602 + L+G L+ + +S A+ A + +LE K++DS +S + R E+ L +K++++ Q Sbjct: 1102 RKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ 1161 Query: 603 LKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVT 662 + EE + A+ + + R A + +++ +LEE S AG + Sbjct: 1162 ARAEELEEEL--EAERAARARVEKQRAEAARELEELSERLEEAGGAS-AGQREGCRKREA 1218 Query: 663 SISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLT 722 + +LE+ + L H T+ A A GA E DSL Sbjct: 1219 ELGRLRRELEE------------AALRHEATVAALRRKQ--AEGAAEL----GEQVDSLQ 1260 Query: 723 EACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL 782 ++ +E + E +E D A L++ KA E+L D E + Sbjct: 1261 RVRQKLEKE--------KSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSE--AKI 1310 Query: 783 VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVAS- 841 +E+ A T R++ + +G+ LE E C S + + L S Sbjct: 1311 KVEELQRQLADASTQRGRLQ-----TESGELSRLLEEKE----CLISQLSRGKALAAQSL 1361 Query: 842 KDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFE 901 ++L+R++ E + ++ L A +A+ ++ + + + + + + Sbjct: 1362 EELRRQLEEESKAKSA--------------LAHAVQALRHDCDLLREQHEEEAEAQAELQ 1407 Query: 902 ELMVCSHEIAASTAQLVAASKVKADKD----SPNLA-QLQQASRGVNQATAGVVASTISG 956 L+ ++ A A ++ ++ LA +LQ+A GV A A S++ Sbjct: 1408 RLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANA--KCSSLEK 1465 Query: 957 KSQIEETDNMDFS-SMTLTQIKRQEMDSQVRVLE--LENELQKERQKLGELRKKHYELAG 1013 +T++ D + + +D + R LE LE ++E + EL E G Sbjct: 1466 AKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRG 1525 Query: 1014 VA-------EGWEEGTEA 1024 + G EE EA Sbjct: 1526 LGTELFRLRHGHEEALEA 1543 Score = 58.2 bits (139), Expect = 4e-08 Identities = 64/280 (22%), Positives = 130/280 (46%), Gaps = 33/280 (11%) Query: 372 EKDHLIERLYR---EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425 +K L E+L + E+S L ++E+ + + Q+ + +L+ ELE +L ++ R + Sbjct: 1121 DKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARAR 1180 Query: 426 AADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNH--- 482 EL+EL + E+ A E RK +A +L+ + E H Sbjct: 1181 VEKQRAEAARELEELSERLEEAGGASAGQREGCRKREA---ELGRLRRELEEAALRHEAT 1237 Query: 483 -ADLLRKN----AEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQL---EV 534 A L RK AE+ +QV ++ + LE+EK EL ++ ++ + T+ + ++ Sbjct: 1238 VAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKL 1297 Query: 535 LESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEK---ERDSLVS----GAAHR 587 + + +L+ ++ +++ LQ L ++ E EL + E++ L+S G A Sbjct: 1298 CRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALA 1357 Query: 588 EEELSALRKELQD---TQLKLASTEESM---CQLAKDQRK 621 + L LR++L++ + LA +++ C L ++Q + Sbjct: 1358 AQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHE 1397 Score = 55.5 bits (132), Expect = 3e-07 Identities = 107/504 (21%), Positives = 209/504 (41%), Gaps = 72/504 (14%) Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCE 431 E + +E + S L+ ++TES+ V L+L+ S A +Q+HL + Sbjct: 1448 EAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERA------ 1501 Query: 432 FLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKN-- 489 L+E RRQ E+ QR L +R+++ +L+ + E ++ L R+N Sbjct: 1502 -----LEERRRQEEEM---QRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKN 1553 Query: 490 -----AEVTKQVSMARQAQVDLEREKKELEDSLERI-SDQGQRKTQEQLEVLESLKQELA 543 +++T QVS++ ++ +LE+ KK LE I + + + +LE ++L+ +L Sbjct: 1554 LQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLE 1613 Query: 544 TSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRK---ELQD 600 SQ + +V + E + +E + SL + R E L +K +L D Sbjct: 1614 LSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLND 1673 Query: 601 TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLE---EPPLISCAGSADHL 657 +L+L Q + Q L+ ++ EQ +D +L + A L Sbjct: 1674 LELQLGHATR---QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLL 1730 Query: 658 LSTVTSISSCIEQLEKS---WSQYLACPEDISGLLHSITL------------LAHLTSDA 702 + + + + +EQ E+S Q L + LLHS LA L+ + Sbjct: 1731 AAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGE- 1789 Query: 703 IAHGATTCLRAPPEPADSLTEACK-----QYGRETLAYLASL---------EEEGSLENA 748 + A A + ++T+A + ++T A+L + E + LE A Sbjct: 1790 VEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEA 1849 Query: 749 DSTAMRNCLSKIKAIGEEL--LPRGLDIKQEELGDLVD---------KEMAATSAAIETA 797 + A+R +++ + ++ L LD +Q++ + + KE+A + Sbjct: 1850 EQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKN 1909 Query: 798 TARIEEMLSKSRAGDTGVKLEVNE 821 AR+++++ K ++ K + E Sbjct: 1910 LARMQDLVDKLQSKVKSYKRQFEE 1933 Score = 52.4 bits (124), Expect = 2e-06 Identities = 84/381 (22%), Positives = 152/381 (39%), Gaps = 74/381 (19%) Query: 425 QAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD 484 QA ++ LRAEL LR +L+ E K Q E+ + + ++ ++L Sbjct: 893 QAEEELAALRAELRGLRG----------ALAAAEAKRQELEETHVSITQEKNDLALQLQA 942 Query: 485 LLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELAT 544 A+ ++ + +++V LE + KEL E+LE E + +LA Sbjct: 943 EQDNLADAEERCHLLIKSKVQLEGKVKELS---------------ERLEDEEEVNADLAA 987 Query: 545 SQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLK 604 +R+L+ E EL+K+ D L A E+E A ++++ + Sbjct: 988 RRRKLE-----------------DECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEE 1030 Query: 605 LASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLE-EPPLISCAGSADHLLSTVTS 663 +A+ +ES+ +L K+ +KA ++ Q AL L+ E +S L Sbjct: 1031 MAALDESVARLTKE---------KKALQEAHQQALGDLQAEEDRVSA------LTKAKLR 1075 Query: 664 ISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTE 723 + +E LE S Q D + LT +++A A + L E Sbjct: 1076 LEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAA--------QDKQQLEE 1127 Query: 724 ACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL- 782 K+ E +E+E L M+ + +++A EEL +++ E Sbjct: 1128 KLKKKDSELSQLSLRVEDEQLL----GAQMQKKIKELQARAEELEE---ELEAERAARAR 1180 Query: 783 VDKEMAATSAAIETATARIEE 803 V+K+ A + +E + R+EE Sbjct: 1181 VEKQRAEAARELEELSERLEE 1201 Score = 50.1 bits (118), Expect = 1e-05 Identities = 106/490 (21%), Positives = 197/490 (40%), Gaps = 71/490 (14%) Query: 559 SAQSEANWAAEFAELEKERDSLVSGAAHR---EEELSALRKELQDTQLKLASTEESMCQL 615 SAQ+E AA AEL R +L + A R EE ++ +E D L+L + ++++ Sbjct: 891 SAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLAD- 949 Query: 616 AKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISC--AGSADHLLSTVTSISSCIEQLE- 672 ++R LL+ S+ E +++ +LE+ ++ A L T + I+ L+ Sbjct: 950 -AEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008 Query: 673 ---KSWSQYLACPEDISGLLHSITLL----AHLTSDAIA-----HGATTCLRAPPEPADS 720 K+ + A + L + L A LT + A A L+A + + Sbjct: 1009 TLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSA 1068 Query: 721 LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELG 780 LT+A + ++ SLE+E L A R L L + QE + Sbjct: 1069 LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRK------------LEGDLKLTQESVA 1116 Query: 781 DLV-DKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV-NERILGCCTSLMQAIQVLI 838 D DK+ ++EE L K + + + L V +E++LG + + I+ L Sbjct: 1117 DAAQDKQ-------------QLEEKLKKKDSELSQLSLRVEDEQLLG--AQMQKKIKELQ 1161 Query: 839 VASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG 898 +++L+ E+ A ++ A+ +R E L + G + + G Sbjct: 1162 ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELG 1221 Query: 899 KFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958 + + E A VAA + K + + L + + + V Q KS Sbjct: 1222 RLRREL---EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLE-------KEKS 1271 Query: 959 QIE-ETDNMDFSSMTLTQIKR-----------QEMDSQVRVLELENELQKERQKLGELRK 1006 ++ E D++ + TLT+ K Q +++++V EL+ +L + G L+ Sbjct: 1272 ELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQT 1331 Query: 1007 KHYELAGVAE 1016 + EL+ + E Sbjct: 1332 ESGELSRLLE 1341 Score = 32.3 bits (72), Expect = 2.4 Identities = 69/326 (21%), Positives = 125/326 (38%), Gaps = 56/326 (17%) Query: 737 ASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIET 796 A EEE + A+ +R L+ +A +EL + I QE+ ++A A + Sbjct: 892 AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEK------NDLALQLQAEQD 945 Query: 797 ATARIEE---MLSKSRAGDTGVKLEVNERI---------LGC--------CTSLMQAIQ- 835 A EE +L KS+ G E++ER+ L CT L + I Sbjct: 946 NLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDD 1005 Query: 836 -VLIVASKDLQREIVESG-----RGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDA 889 L +A + +++ E+ A+ E A+ ++ + L A + D Sbjct: 1006 LKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDR 1065 Query: 890 ADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGV 949 + + + + E+ ++ L K++ D + + ++ G + T Sbjct: 1066 VSALTKAKLRLEQ------QVEDLECSLEQEKKLRMDTE-----RAKRKLEGDLKLTQES 1114 Query: 950 VASTISGKSQIEET---DNMDFSSMTL---------TQIKRQEMDSQVRVLELENELQKE 997 VA K Q+EE + + S ++L Q++++ + Q R ELE EL+ E Sbjct: 1115 VADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAE 1174 Query: 998 RQKLGELRKKHYELAGVAEGWEEGTE 1023 R + K+ E A E E E Sbjct: 1175 RAARARVEKQRAEAARELEELSERLE 1200 Score = 30.4 bits (67), Expect = 9.0 Identities = 24/112 (21%), Positives = 52/112 (46%), Gaps = 14/112 (12%) Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGH---VSELEADLAEQQHLRQQAADDCEFL 433 +++L ++ L+A+L+ + + + ++ H V EL E + + D + L Sbjct: 1861 VQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKL 1920 Query: 434 RAELDELRRQREDTE-----------KAQRSLSEIERKAQANEQRYSKLKEK 474 ++++ +RQ E+ E KAQ L + E +A E + +KL+ + Sbjct: 1921 QSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRAR 1972 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 71.2 bits (173), Expect = 5e-12 Identities = 153/707 (21%), Positives = 283/707 (40%), Gaps = 102/707 (14%) Query: 365 QNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQ 424 Q + +++ + RL +E +A L K + ++L+ ++E + A Q Sbjct: 994 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053 Query: 425 QAADDCEFLRAELDELR----RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSE--- 477 A + E EL +LR Q ++ E+ ++++ +++ + E+ ++ SE Sbjct: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113 Query: 478 --------LVQNHADLLRKNAEVTKQVSMARQAQVDLEREKK---ELEDSLERISDQGQR 526 L A++ + + KQ A + LE E+ E + +LE + Q + Sbjct: 1114 RTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE 1173 Query: 527 KTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAH 586 K QE L + LA++QREL + ++ +++E W A+ A +E + S + Sbjct: 1174 KAQE----LGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISS 1229 Query: 587 REEELS-----ALRKELQDTQLK-LASTEESMCQLAKDQRKMLLV----GSRKAAEQ--V 634 EEE+S L KE + +LK L E Q +++ ++L S +AAE+ Sbjct: 1230 LEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSA 1289 Query: 635 IQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLE---KSWSQYLACPEDISGLLHS 691 +++ + L E S ++L +TS + E+L K+W + E Sbjct: 1290 LREEVQSLREEAEKQRVAS-ENLRQELTSQAERAEELGQELKAWQEKFFQKEQA------ 1342 Query: 692 ITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADST 751 L++ + H +T L + PA L C+Q E A A LE + Sbjct: 1343 ------LSTLQLEHTSTQALVSELLPAKHL---CQQLQAEQAA--AEKRHREELEQSKQA 1391 Query: 752 AMRNCLSKIKAIGEELLPRGLDIKQEELGDLVD-----KEMAATSAAIETATARIEEMLS 806 A + ELL Q ELG+L+ E T+ + A E LS Sbjct: 1392 A--------GGLRAELLR-----AQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLS 1438 Query: 807 KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPK-EFYAKN 865 + G+ E N + Q ++V + +++ + + + R A + + Sbjct: 1439 MLKKAH-GLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQRE 1497 Query: 866 SRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASK--- 922 ++ T + A GA V V++ R +F+E ++ A QL + Sbjct: 1498 AQSTARELEVMTAKYEGAKVK------VLEERQRFQEE---RQKLTAQVEQLEVFQREQT 1548 Query: 923 VKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMD 982 + ++ S LA QAS+ Q V A G+SQ E + Q+ ++E Sbjct: 1549 KQVEELSKKLADSDQASKVQQQKLKAVQAQ--GGESQQEAQRLQAQLNELQAQLSQKEQA 1606 Query: 983 SQVRVLELE-------------NELQKERQKLGELRKKHYELAGVAE 1016 ++ L++E ELQ++ + L +L+K++ EL AE Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAE 1653 Score = 67.8 bits (164), Expect = 5e-11 Identities = 142/686 (20%), Positives = 269/686 (39%), Gaps = 80/686 (11%) Query: 370 KDEKDHLIERLYRE---ISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426 K+++ L + L ++ GL+ Q+E + + ++ QLK + EA + A Sbjct: 529 KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588 Query: 427 ADDCEFLRAELDELRRQREDTEKAQRSLSEI-ERKAQANEQRYSKLKEKYSELVQNHADL 485 A++ E E D +Q E EK + + EI +++ Q + + ++ + A+L Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648 Query: 486 LRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATS 545 RK E+ V ARQ Q + + + ELE L R Q + + + + L+++L Sbjct: 649 SRKVEELQACVETARQEQHEAQAQVAELELQL-RSEQQKATEKERVAQEKDQLQEQLQAL 707 Query: 546 QRELQVLQGSLETSAQSEANWAAE----FAELEKERDSLVSGAAHREEELSALRKELQDT 601 + L+V +GSLE + A+ E +EL+ E SLV H+ E RKEL++ Sbjct: 708 KESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE--QHKRE-----RKELEEE 760 Query: 602 QLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLI------------S 649 + E + QL + + V R+ AE + + E L+ S Sbjct: 761 RAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS 820 Query: 650 CAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATT 709 A + + + E+ EK+ + E ++G+ L + +A Sbjct: 821 QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880 Query: 710 CLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENAD----STAMRNCLSKIKAIGE 765 RA + + A ++ L++L+E+ + + + T +R + + Sbjct: 881 LARALQQVQEKEVRA-----QKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASR 935 Query: 766 ELL---PRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNER 822 EL+ R D + E L + ++ +T AA++ E+M G +LE Sbjct: 936 ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM---------GNELERLRA 986 Query: 823 ILGCCTSLMQAIQVLIVASKDLQREIVESGRGTAS---PKEFYAKNSRWTEGLISASKAV 879 L S Q + +++ R E GR A K A+ + ++ + Sbjct: 987 AL--MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVE 1044 Query: 880 GWGATVMVDAADLVVQGRGKFEEL---------MVCSHEIAASTAQLVAASKVKADKDSP 930 AT+ A + + GK +EL + E T + + K +K+ Sbjct: 1045 --FATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHA 1102 Query: 931 NLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLEL 990 + + Q + G + T + + + S++E+ Q ++++ DS R LE Sbjct: 1103 SGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ----------CQKQQEQADSLERSLEA 1152 Query: 991 ENELQKERQKL-----GELRKKHYEL 1011 E + ER G+L +K EL Sbjct: 1153 ERASRAERDSALETLQGQLEEKAQEL 1178 Score = 66.2 bits (160), Expect = 1e-10 Identities = 142/705 (20%), Positives = 266/705 (37%), Gaps = 98/705 (13%) Query: 391 LENMKTESQRVVLQL---KGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDT 447 L+ + + +R+ QL + + ELE +LAE + L + ++ +D L E Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268 Query: 448 EKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLE 507 + E+E NE +L E + DL + +++ ++++ + DL Sbjct: 269 AASPLEPKELEELRDKNESLTMRLHETLKQC----QDLKTEKSQMDRKINQLSEENGDLS 324 Query: 508 REKKE-------LEDSLERISDQGQRKTQEQLEVLESLKQELATS-------QRELQVLQ 553 + +E L+D+L ++++ + TQE LE L++EL+ + + + ++LQ Sbjct: 325 FKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQ 384 Query: 554 GSL----ETSAQSEANWAAEFAE----------LEKERDSLVSGAAHREEELSALRKELQ 599 G L E +Q + N E E L++E +L + + + L E Sbjct: 385 GKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERG 444 Query: 600 DTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQ--DALNQLEEPPLISCAGSADHL 657 + KL + E + K Q L+ + + + Q + L Q + L Sbjct: 445 QQEAKLLA-ERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503 Query: 658 LSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEP 717 S +T++++ I+Q ++ + ++ L S + H + + Sbjct: 504 TSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQK 563 Query: 718 ADSL------TEACKQYGRETLAYLASLEEEGSLENADSTAMR-NCLSKIKAIGEELLPR 770 L EA +Q + LA A+ E E SL D+ + L K KA E+L + Sbjct: 564 EQQLKEVAEKQEATRQDHAQQLA-TAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622 Query: 771 GLDIKQEELGDL------VDKEMAATSAAIE-----TATARIEEMLSKSRAGDTGVKLE- 818 L + E +E A S +E TAR E+ ++++ + ++L Sbjct: 623 QLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS 682 Query: 819 ------VNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGL 872 ER+ L + +Q L + K + + E R A E + Sbjct: 683 EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR-------C 735 Query: 873 ISASKAVGWGATVMVDAADLVVQ---GRGKFEELMVCSHEIAASTAQLVAASKVKADKDS 929 IS KA + LV Q R + EE + A QL A + + + Sbjct: 736 ISELKA---------ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLR 786 Query: 930 PNLAQLQQASRGVNQATAGVVASTISGKSQIEET--DNMDFSSMTLTQI----------- 976 LA+ A +V + + + E++ + + +M Q+ Sbjct: 787 RELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846 Query: 977 -KRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEE 1020 + QE +V +E +ELQ RQ+ EL + H LA + +E Sbjct: 847 QELQEAKEKVAGIESHSELQISRQQ-NELAELHANLARALQQVQE 890 Score = 58.5 bits (140), Expect = 3e-08 Identities = 133/559 (23%), Positives = 219/559 (39%), Gaps = 74/559 (13%) Query: 503 QVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQ-RELQVLQGSLETSAQ 561 Q + R KK+L D +R +++LE+ + ++L T + ++ ++Q ++ A Sbjct: 213 QFQMRRLKKQLAD---------ERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL 263 Query: 562 SEANWAA---EFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKD 618 AA E ELE+ RD S E L K+ QD + + + + + QL+++ Sbjct: 264 LNEKQAASPLEPKELEELRDKNESLTMRLHETL----KQCQDLKTEKSQMDRKINQLSEE 319 Query: 619 QRKMLLVGSRKAAE-QVIQDALNQLEEP------PLISCAGSADHLLSTVTSISSCIE-- 669 + A+ Q +QDALN+L E + + LS C+E Sbjct: 320 NGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEK 379 Query: 670 ---------QLEKSWSQYLACPEDISG-LLHSITLLAHLTSDAIAHGAT-TCLRAPPEPA 718 QLE+ SQ P G +L + L L +A A T L+A E Sbjct: 380 NEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEML 439 Query: 719 DSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEE 778 + TE +Q + LA EEE ++ T +++ +S + EEL + + Sbjct: 440 E--TERGQQEAK-LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEEL-----EQASQA 491 Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLI 838 G + ++A+ ++ + T A I++ + G+K + E+ +L Q Q Sbjct: 492 HGARLTAQVASLTSELTTLNATIQQQDQEL----AGLKQQAKEKQAQLAQTLQQQEQ--- 544 Query: 839 VASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG 898 AS+ L+ + VE + KE K A AT A L Sbjct: 545 -ASQGLRHQ-VEQLSSSLKQKEQQLKEV-----------AEKQEATRQDHAQQLATAA-- 589 Query: 899 KFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958 EE E A+ QL A K KA K L LQQ + N+A S + Sbjct: 590 --EEREASLRERDAALKQLEALEKEKAAK----LEILQQQLQVANEARDSAQTSVTQAQR 643 Query: 959 QIEETDNMDFSSMTLTQIKRQEM-DSQVRVLELENELQKERQKLGELRKKHYELAGVAEG 1017 + E + RQE ++Q +V ELE +L+ E+QK E + E + E Sbjct: 644 EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ 703 Query: 1018 WEEGTEASPPTLQEVVTEK 1036 + E+ T + EK Sbjct: 704 LQALKESLKVTKGSLEEEK 722 Score = 45.4 bits (106), Expect = 3e-04 Identities = 55/275 (20%), Positives = 112/275 (40%), Gaps = 12/275 (4%) Query: 353 SSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSEL 412 +S++ +G+ +E L ER L+ +L+ + ++ V +L ++ Sbjct: 1431 ASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAR---EKYVQELAAVRADA 1487 Query: 413 EADLAEQQHLRQQAADDCEFLRAE--------LDELRRQREDTEKAQRSLSEIERKAQAN 464 E LAE Q Q A + E + A+ L+E +R +E+ +K + ++E + Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQ 1547 Query: 465 EQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQG 524 ++ +L +K ++ Q +K V Q ++Q L+ + EL+ L + +Q Sbjct: 1548 TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ-KEQA 1606 Query: 525 QRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGA 584 + Q+E ++ +ELQ SLE + AE L E Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKT 1666 Query: 585 AHREEELSALRKELQDTQLKLASTEESMCQLAKDQ 619 E+ L +++ + ++A ++ + L K Q Sbjct: 1667 KEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQ 1701 >gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo sapiens] Length = 1941 Score = 71.2 bits (173), Expect = 5e-12 Identities = 109/507 (21%), Positives = 217/507 (42%), Gaps = 64/507 (12%) Query: 370 KDEKDHLIERLYR---EISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLR 423 ++EK L E+L + EIS L++++E+ + + Q+ + +L+ + ELE ++ ++ R Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135 Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483 +A L EL+E+ + E+ A + E+ +K +A Q+ + E+ + + A Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195 Query: 484 DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRKTQEQL 532 LRK AE+ +Q+ ++ + LE+EK E++ ++ ++ + + ++ Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255 Query: 533 EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHRE 588 LE EL + + E Q L L + EF+ E+++LVS G Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315 Query: 589 EELSALRKELQD---TQLKLASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQVI 635 +++ L+++L++ + LA +S C L ++Q + L KA +V Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375 Query: 636 Q-------DALNQLEE-----PPLISCAGSADHLLSTV----TSISSCIEQLEKSWSQYL 679 Q DA+ + EE L +A+ + V S+ ++L+ + Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435 Query: 680 ACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETL----AY 735 E + ++ +A C E S EA + G E AY Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEA-RSLGTELFKIKNAY 1494 Query: 736 LASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQ-EELGDLVDKEMAATSAAI 794 SL++ +L+ + +N +I + E++ G I + E++ V++E AA+ Sbjct: 1495 EESLDQLETLKREN----KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550 Query: 795 ETATARIEEMLSKSRAGDTGVKLEVNE 821 E A A +E K ++LE+N+ Sbjct: 1551 EEAEASLEHEEGKI----LRIQLELNQ 1573 Score = 63.9 bits (154), Expect = 7e-10 Identities = 98/462 (21%), Positives = 191/462 (41%), Gaps = 77/462 (16%) Query: 240 VKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFL 299 +KL FK+ L + + E+F K+KD +S + + L E L Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895 Query: 300 RASALSEHISPV-----------VVIPAEASSPDSEPVLEKDDLMDMDASQQNLFD---- 344 + A +E ++ + + A+ E++ ++ A ++ L D Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955 Query: 345 --NKFDDIFGSSFSSDPFNFNSQNGV-NKDEK----DHLIERLYREISGL----KAQLEN 393 DD+ + + ++N V N E+ D I +L +E L + L++ Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015 Query: 394 MKTESQRV------VLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRE-D 446 ++ E +V ++L+ V +LE L +++ LR +L+ +R+ E D Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-----------DLERAKRKLEGD 1064 Query: 447 TEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD--------------LLRKNAEV 492 + AQ S+ +IE + Q +++ K + + S L D L + E+ Sbjct: 1065 LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL 1124 Query: 493 TKQVSMARQAQVDLEREKKELEDSLERISDQGQR---KTQEQLEVLESLKQELATSQREL 549 +++ R ++ E+++ +L LE IS++ + T Q+E+ + + E +R+L Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1184 Query: 550 QVLQGSLE---TSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD------ 600 + + +L+ T+A A AEL ++ D+L E+E S ++ E+ D Sbjct: 1185 E--EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242 Query: 601 TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQL 642 T K E MC+ +DQ L K+ E+ Q +N L Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSEL-----KSKEEEQQRLINDL 1279 Score = 60.1 bits (144), Expect = 1e-08 Identities = 95/516 (18%), Positives = 218/516 (42%), Gaps = 77/516 (14%) Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436 +E+ ++ G Q + ++ + +R +L+G + + + + ++ +QQ + + E Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE 1092 Query: 437 LDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492 + L+ + ED + + Q+ + E++ + + E+ + ++ + +DL R+ E+ Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152 Query: 493 TK-----------QVSMARQAQVDLEREKKELED----------SLERISDQGQRKTQEQ 531 ++ Q+ M ++ + + ++ +++LE+ +L + + EQ Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212 Query: 532 LEVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587 ++ L+ +KQ+L + E+++ L ++ET ++++ N LE + L S + Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS----K 1268 Query: 588 EEELSALRKEL--QDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEP 645 EEE L +L Q +L+ S E S K+ L ++A Q I++ QLEE Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328 Query: 646 PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705 I + H L + + + QY E + L +++ + +A Sbjct: 1329 --IKAKNALAHALQSSRHDCDLLRE------QYEEEQESKAELQRALS----KANTEVAQ 1376 Query: 706 GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGE 765 T + + L EA K+ + L + EE NA ++ +++ E Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQR----LQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432 Query: 766 ELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLS--KSRAGDTGVKLEVNE-- 821 +L+ LD+++ A AA++ +++L+ K + +T +LE ++ Sbjct: 1433 DLM---LDVERTN----------AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE 1479 Query: 822 ---------RILGCCTSLMQAIQVLIVASKDLQREI 848 +I + ++ L +K+LQ+EI Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEI 1515 Score = 59.3 bits (142), Expect = 2e-08 Identities = 136/675 (20%), Positives = 268/675 (39%), Gaps = 69/675 (10%) Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHL-------RQ 424 EK+ L ++ E GL A E + + +QL+ + E+ +++ + ++ Sbjct: 889 EKNDLQLQVQAEAEGL-ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKR 947 Query: 425 QAADDCEFLRAELDELRRQREDTEK----AQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480 + D+C L+ ++D+L EK + + + + ++ +KL ++ L + Sbjct: 948 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007 Query: 481 NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRK------- 527 H L +V+ +A++ LE++ +LE SLE+ ++ +RK Sbjct: 1008 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067 Query: 528 TQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587 QE + +E+ KQ+L ++ + +L++ + E A +L+K+ L + Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE---QALGIQLQKKIKELQARIEEL 1124 Query: 588 EEELSALR-------KELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN 640 EEE+ A R K+ D +L E + + + + ++ AE Q Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE--FQKMRR 1182 Query: 641 QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS 700 LEE L A +A S++ EQ++ ++ S + I Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI-------- 1234 Query: 701 DAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKI 760 D +A T +A +L + C+ + L+ L S EEE D TA R L Sbjct: 1235 DDLASNVETVSKA----KGNLEKMCRTL-EDQLSELKSKEEEQQRLINDLTAQRGRLQ-- 1287 Query: 761 KAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN 820 GE R LD K+ + L + A T IE ++EE + A ++ + Sbjct: 1288 TESGE--FSRQLDEKEALVSQLSRGKQAFTQ-QIEELKRQLEEEIKAKNALAHALQSSRH 1344 Query: 821 ERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNS-RWTEGLISASKAV 879 + C L + + + +LQR + ++ A + Y ++ + TE L A K + Sbjct: 1345 D-----CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399 Query: 880 G---WGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQ-L 935 A V+A + K ++ + E + A+ DK N + L Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459 Query: 936 QQASRGVNQATAGVVASTISGKS---QIEETDNMDFSSM-TLTQIKRQEMDSQVRVLELE 991 + + + A + AS +S ++ + N S+ L +KR+ + Q + +L Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1519 Query: 992 NELQKERQKLGELRK 1006 ++ + +++ EL K Sbjct: 1520 EQIAEGGKRIHELEK 1534 Score = 55.5 bits (132), Expect = 3e-07 Identities = 68/284 (23%), Positives = 129/284 (45%), Gaps = 42/284 (14%) Query: 388 KAQLENMKTESQRVVLQLKGHVSELEADLAEQQH----LRQQAADDCEFLRAELDELRRQ 443 +A LE+ + + R+ L+L SE++ +AE+ L++ E +++ LD R Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS 1613 Query: 444 REDT----EKAQRSLSEIE-------RKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492 R D +K + L+E+E R A + Y + + + D LR ++ Sbjct: 1614 RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673 Query: 493 TKQVSMARQAQVDLEREKKELEDSLE------RISDQGQRKTQEQLEVLESLKQELATSQ 546 +Q++M + L+ E +EL +LE +I++Q E++++L + L ++ Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1733 Query: 547 RELQV----LQGSLETSAQSEANWAAEFA------------ELEKERDSLVSGAAHREEE 590 ++L+ +QG +E Q EA A E A EL+KE+D+ +AH E Sbjct: 1734 KKLETDISQMQGEMEDILQ-EARNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERM 1788 Query: 591 LSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQV 634 + + ++D QL+L E+ + K Q + L R+ +V Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1832 Score = 52.8 bits (125), Expect = 2e-06 Identities = 120/668 (17%), Positives = 260/668 (38%), Gaps = 89/668 (13%) Query: 410 SELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYS 469 +E E ++A + Q+ D+ A+ EL + K + ++++ + QA + + Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK---NDLQLQVQAEAEGLA 905 Query: 470 KLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQ 529 +E+ +L++ L K EVT++ + +L +K++LED + Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD------ 959 Query: 530 EQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREE 589 ++ L+ LA ++E + ++ + A A+L KE+ +L + Sbjct: 960 -----IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014 Query: 590 ELSA------------LRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637 +L A ++ E Q L+ + +E ++ ++ K L G K A++ I D Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074 Query: 638 ALNQLE--EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695 N+ + + L +L S + + QL+K + A E++ + Sbjct: 1075 IENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE----- 1129 Query: 696 AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLE-------------EE 742 A S A A + L + ++E ++ G T A + + EE Sbjct: 1130 AERASRAKAEKQRSDL---SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186 Query: 743 GSL--ENADSTAMRNCLSKIKAIGEEL-----LPRGLDIKQEELGDLVDKEMAATSAAIE 795 +L E +T + + +GE++ + + L+ ++ E+ +D ++A+ + Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-DLASNVETVS 1245 Query: 796 TATARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES-- 851 A +E+M + + + K E +R++ T+ +Q S + R++ E Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ---TESGEFSRQLDEKEA 1302 Query: 852 -----GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVC 906 RG + + + R E I A A+ DL+ R ++EE Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL---REQYEEEQES 1359 Query: 907 SHEIAASTAQL---VAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962 E+ + ++ VA + K + D+ +L++A + +A + + E Sbjct: 1360 KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVE 1411 Query: 963 TDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022 N +S+ T +Q + ++V L L ++++ L KK + W++ Sbjct: 1412 AVNAKCASLEKT---KQRLQNEVEDLML--DVERTNAACAALDKKQRNFDKILAEWKQKC 1466 Query: 1023 EASPPTLQ 1030 E + L+ Sbjct: 1467 EETHAELE 1474 Score = 44.7 bits (104), Expect = 5e-04 Identities = 75/363 (20%), Positives = 153/363 (42%), Gaps = 52/363 (14%) Query: 370 KDEKDHLIERLY---REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426 ++ K L +RL + + A+ +++ QR+ +++ + ++E A L ++ Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452 Query: 427 ADDCEFL---RAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELV 479 + + L + + +E + E ++K RSL +I+ + + + LK + L Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQ 1512 Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE--------------------- 518 Q +DL + AE K++ + + +E+EK EL+ +LE Sbjct: 1513 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELN 1572 Query: 519 RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFA 571 ++ + RK E+ E ++ LK+ R ++ +Q +L+ +S + + Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKR---NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629 Query: 572 ELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLAKDQRKMLLVGS 627 E+E + + AA + L+DTQ+ L S E+ QLA +R+ L+ + Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689 Query: 628 -----RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682 R EQ + ++ E L+ + L + TS+ + ++LE SQ Sbjct: 1690 EIEELRATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747 Query: 683 EDI 685 EDI Sbjct: 1748 EDI 1750 Score = 44.7 bits (104), Expect = 5e-04 Identities = 60/296 (20%), Positives = 124/296 (41%), Gaps = 49/296 (16%) Query: 361 NFNSQNGVNKDEKDHL----------------IER----LYREISGLKAQLENMKTE--- 397 N+ + G+ KD + HL +ER L EI L+A LE + Sbjct: 1648 NYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI 1707 Query: 398 --------SQRVVLQLKGHVS------ELEADLAEQQ----HLRQQAADDCEFLRAELDE 439 S+RV L + S +LE D+++ Q + Q+A + E + + + Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767 Query: 440 LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMA 499 E+ +K Q + + +ER + EQ L+ + E Q L ++ K + Sbjct: 1768 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ--LALKGGKKQIQKLEARV 1825 Query: 500 RQAQVDLEREKKELEDSLERISDQGQR------KTQEQLEVLESLKQELATSQRELQVLQ 553 R+ + ++E E+K ++++ + +R +T+E + + L+ + Q +++ + Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885 Query: 554 GSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609 E + + A+F +L+ E + A E +++ LR + ++ K+ S E Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941 >gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo sapiens] Length = 1941 Score = 71.2 bits (173), Expect = 5e-12 Identities = 109/507 (21%), Positives = 217/507 (42%), Gaps = 64/507 (12%) Query: 370 KDEKDHLIERLYR---EISGLKAQLENMKT---ESQRVVLQLKGHVSELEADLAEQQHLR 423 ++EK L E+L + EIS L++++E+ + + Q+ + +L+ + ELE ++ ++ R Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135 Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483 +A L EL+E+ + E+ A + E+ +K +A Q+ + E+ + + A Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195 Query: 484 DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRKTQEQL 532 LRK AE+ +Q+ ++ + LE+EK E++ ++ ++ + + ++ Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255 Query: 533 EVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----GAAHRE 588 LE EL + + E Q L L + EF+ E+++LVS G Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315 Query: 589 EELSALRKELQD---TQLKLASTEESM---CQLAKDQ-------RKMLLVGSRKAAEQVI 635 +++ L+++L++ + LA +S C L ++Q + L KA +V Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375 Query: 636 Q-------DALNQLEE-----PPLISCAGSADHLLSTV----TSISSCIEQLEKSWSQYL 679 Q DA+ + EE L +A+ + V S+ ++L+ + Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435 Query: 680 ACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETL----AY 735 E + ++ +A C E S EA + G E AY Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEA-RSLGTELFKIKNAY 1494 Query: 736 LASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQ-EELGDLVDKEMAATSAAI 794 SL++ +L+ + +N +I + E++ G I + E++ V++E AA+ Sbjct: 1495 EESLDQLETLKREN----KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550 Query: 795 ETATARIEEMLSKSRAGDTGVKLEVNE 821 E A A +E K ++LE+N+ Sbjct: 1551 EEAEASLEHEEGKI----LRIQLELNQ 1573 Score = 63.9 bits (154), Expect = 7e-10 Identities = 98/462 (21%), Positives = 191/462 (41%), Gaps = 77/462 (16%) Query: 240 VKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFL 299 +KL FK+ L + + E+F K+KD +S + + L E L Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895 Query: 300 RASALSEHISPV-----------VVIPAEASSPDSEPVLEKDDLMDMDASQQNLFD---- 344 + A +E ++ + + A+ E++ ++ A ++ L D Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955 Query: 345 --NKFDDIFGSSFSSDPFNFNSQNGV-NKDEK----DHLIERLYREISGL----KAQLEN 393 DD+ + + ++N V N E+ D I +L +E L + L++ Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015 Query: 394 MKTESQRV------VLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRE-D 446 ++ E +V ++L+ V +LE L +++ LR +L+ +R+ E D Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-----------DLERAKRKLEGD 1064 Query: 447 TEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHAD--------------LLRKNAEV 492 + AQ S+ +IE + Q +++ K + + S L D L + E+ Sbjct: 1065 LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL 1124 Query: 493 TKQVSMARQAQVDLEREKKELEDSLERISDQGQR---KTQEQLEVLESLKQELATSQREL 549 +++ R ++ E+++ +L LE IS++ + T Q+E+ + + E +R+L Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1184 Query: 550 QVLQGSLE---TSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD------ 600 + + +L+ T+A A AEL ++ D+L E+E S ++ E+ D Sbjct: 1185 E--EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242 Query: 601 TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQL 642 T K E MC+ +DQ L K+ E+ Q +N L Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSEL-----KSKEEEQQRLINDL 1279 Score = 60.1 bits (144), Expect = 1e-08 Identities = 95/516 (18%), Positives = 218/516 (42%), Gaps = 77/516 (14%) Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436 +E+ ++ G Q + ++ + +R +L+G + + + + ++ +QQ + + E Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE 1092 Query: 437 LDELRRQREDTE----KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492 + L+ + ED + + Q+ + E++ + + E+ + ++ + +DL R+ E+ Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152 Query: 493 TK-----------QVSMARQAQVDLEREKKELED----------SLERISDQGQRKTQEQ 531 ++ Q+ M ++ + + ++ +++LE+ +L + + EQ Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212 Query: 532 LEVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587 ++ L+ +KQ+L + E+++ L ++ET ++++ N LE + L S + Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS----K 1268 Query: 588 EEELSALRKEL--QDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEP 645 EEE L +L Q +L+ S E S K+ L ++A Q I++ QLEE Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328 Query: 646 PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705 I + H L + + + QY E + L +++ + +A Sbjct: 1329 --IKAKNALAHALQSSRHDCDLLRE------QYEEEQESKAELQRALS----KANTEVAQ 1376 Query: 706 GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGE 765 T + + L EA K+ + L + EE NA ++ +++ E Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQR----LQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432 Query: 766 ELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLS--KSRAGDTGVKLEVNE-- 821 +L+ LD+++ A AA++ +++L+ K + +T +LE ++ Sbjct: 1433 DLM---LDVERTN----------AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE 1479 Query: 822 ---------RILGCCTSLMQAIQVLIVASKDLQREI 848 +I + ++ L +K+LQ+EI Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEI 1515 Score = 59.3 bits (142), Expect = 2e-08 Identities = 136/675 (20%), Positives = 268/675 (39%), Gaps = 69/675 (10%) Query: 372 EKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHL-------RQ 424 EK+ L ++ E GL A E + + +QL+ + E+ +++ + ++ Sbjct: 889 EKNDLQLQVQAEAEGL-ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKR 947 Query: 425 QAADDCEFLRAELDELRRQREDTEK----AQRSLSEIERKAQANEQRYSKLKEKYSELVQ 480 + D+C L+ ++D+L EK + + + + ++ +KL ++ L + Sbjct: 948 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007 Query: 481 NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERIS------DQGQRK------- 527 H L +V+ +A++ LE++ +LE SLE+ ++ +RK Sbjct: 1008 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067 Query: 528 TQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587 QE + +E+ KQ+L ++ + +L++ + E A +L+K+ L + Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE---QALGIQLQKKIKELQARIEEL 1124 Query: 588 EEELSALR-------KELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN 640 EEE+ A R K+ D +L E + + + + ++ AE Q Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE--FQKMRR 1182 Query: 641 QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS 700 LEE L A +A S++ EQ++ ++ S + I Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI-------- 1234 Query: 701 DAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKI 760 D +A T +A +L + C+ + L+ L S EEE D TA R L Sbjct: 1235 DDLASNVETVSKA----KGNLEKMCRTL-EDQLSELKSKEEEQQRLINDLTAQRGRLQ-- 1287 Query: 761 KAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN 820 GE R LD K+ + L + A T IE ++EE + A ++ + Sbjct: 1288 TESGE--FSRQLDEKEALVSQLSRGKQAFTQ-QIEELKRQLEEEIKAKNALAHALQSSRH 1344 Query: 821 ERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNS-RWTEGLISASKAV 879 + C L + + + +LQR + ++ A + Y ++ + TE L A K + Sbjct: 1345 D-----CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399 Query: 880 G---WGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQ-L 935 A V+A + K ++ + E + A+ DK N + L Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459 Query: 936 QQASRGVNQATAGVVASTISGKS---QIEETDNMDFSSM-TLTQIKRQEMDSQVRVLELE 991 + + + A + AS +S ++ + N S+ L +KR+ + Q + +L Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1519 Query: 992 NELQKERQKLGELRK 1006 ++ + +++ EL K Sbjct: 1520 EQIAEGGKRIHELEK 1534 Score = 55.5 bits (132), Expect = 3e-07 Identities = 68/284 (23%), Positives = 129/284 (45%), Gaps = 42/284 (14%) Query: 388 KAQLENMKTESQRVVLQLKGHVSELEADLAEQQH----LRQQAADDCEFLRAELDELRRQ 443 +A LE+ + + R+ L+L SE++ +AE+ L++ E +++ LD R Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS 1613 Query: 444 REDT----EKAQRSLSEIE-------RKAQANEQRYSKLKEKYSELVQNHADLLRKNAEV 492 R D +K + L+E+E R A + Y + + + D LR ++ Sbjct: 1614 RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673 Query: 493 TKQVSMARQAQVDLEREKKELEDSLE------RISDQGQRKTQEQLEVLESLKQELATSQ 546 +Q++M + L+ E +EL +LE +I++Q E++++L + L ++ Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1733 Query: 547 RELQV----LQGSLETSAQSEANWAAEFA------------ELEKERDSLVSGAAHREEE 590 ++L+ +QG +E Q EA A E A EL+KE+D+ +AH E Sbjct: 1734 KKLETDISQMQGEMEDILQ-EARNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERM 1788 Query: 591 LSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQV 634 + + ++D QL+L E+ + K Q + L R+ +V Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1832 Score = 52.8 bits (125), Expect = 2e-06 Identities = 120/668 (17%), Positives = 260/668 (38%), Gaps = 89/668 (13%) Query: 410 SELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYS 469 +E E ++A + Q+ D+ A+ EL + K + ++++ + QA + + Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK---NDLQLQVQAEAEGLA 905 Query: 470 KLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQ 529 +E+ +L++ L K EVT++ + +L +K++LED + Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD------ 959 Query: 530 EQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREE 589 ++ L+ LA ++E + ++ + A A+L KE+ +L + Sbjct: 960 -----IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014 Query: 590 ELSA------------LRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQD 637 +L A ++ E Q L+ + +E ++ ++ K L G K A++ I D Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074 Query: 638 ALNQLE--EPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLL 695 N+ + + L +L S + + QL+K + A E++ + Sbjct: 1075 IENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE----- 1129 Query: 696 AHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLE-------------EE 742 A S A A + L + ++E ++ G T A + + EE Sbjct: 1130 AERASRAKAEKQRSDL---SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186 Query: 743 GSL--ENADSTAMRNCLSKIKAIGEEL-----LPRGLDIKQEELGDLVDKEMAATSAAIE 795 +L E +T + + +GE++ + + L+ ++ E+ +D ++A+ + Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-DLASNVETVS 1245 Query: 796 TATARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES-- 851 A +E+M + + + K E +R++ T+ +Q S + R++ E Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ---TESGEFSRQLDEKEA 1302 Query: 852 -----GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVC 906 RG + + + R E I A A+ DL+ R ++EE Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL---REQYEEEQES 1359 Query: 907 SHEIAASTAQL---VAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEE 962 E+ + ++ VA + K + D+ +L++A + +A + + E Sbjct: 1360 KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVE 1411 Query: 963 TDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGT 1022 N +S+ T +Q + ++V L L ++++ L KK + W++ Sbjct: 1412 AVNAKCASLEKT---KQRLQNEVEDLML--DVERTNAACAALDKKQRNFDKILAEWKQKC 1466 Query: 1023 EASPPTLQ 1030 E + L+ Sbjct: 1467 EETHAELE 1474 Score = 44.7 bits (104), Expect = 5e-04 Identities = 75/363 (20%), Positives = 153/363 (42%), Gaps = 52/363 (14%) Query: 370 KDEKDHLIERLY---REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQA 426 ++ K L +RL + + A+ +++ QR+ +++ + ++E A L ++ Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452 Query: 427 ADDCEFL---RAELDELRRQREDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSELV 479 + + L + + +E + E ++K RSL +I+ + + + LK + L Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQ 1512 Query: 480 QNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE--------------------- 518 Q +DL + AE K++ + + +E+EK EL+ +LE Sbjct: 1513 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELN 1572 Query: 519 RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAAEFA 571 ++ + RK E+ E ++ LK+ R ++ +Q +L+ +S + + Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKR---NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629 Query: 572 ELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLAKDQRKMLLVGS 627 E+E + + AA + L+DTQ+ L S E+ QLA +R+ L+ + Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689 Query: 628 -----RKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682 R EQ + ++ E L+ + L + TS+ + ++LE SQ Sbjct: 1690 EIEELRATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747 Query: 683 EDI 685 EDI Sbjct: 1748 EDI 1750 Score = 44.7 bits (104), Expect = 5e-04 Identities = 60/296 (20%), Positives = 124/296 (41%), Gaps = 49/296 (16%) Query: 361 NFNSQNGVNKDEKDHL----------------IER----LYREISGLKAQLENMKTE--- 397 N+ + G+ KD + HL +ER L EI L+A LE + Sbjct: 1648 NYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI 1707 Query: 398 --------SQRVVLQLKGHVS------ELEADLAEQQ----HLRQQAADDCEFLRAELDE 439 S+RV L + S +LE D+++ Q + Q+A + E + + + Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767 Query: 440 LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMA 499 E+ +K Q + + +ER + EQ L+ + E Q L ++ K + Sbjct: 1768 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ--LALKGGKKQIQKLEARV 1825 Query: 500 RQAQVDLEREKKELEDSLERISDQGQR------KTQEQLEVLESLKQELATSQRELQVLQ 553 R+ + ++E E+K ++++ + +R +T+E + + L+ + Q +++ + Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885 Query: 554 GSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609 E + + A+F +L+ E + A E +++ LR + ++ K+ S E Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941 >gi|31982906 cingulin-like 1 [Homo sapiens] Length = 1302 Score = 70.9 bits (172), Expect = 6e-12 Identities = 148/715 (20%), Positives = 288/715 (40%), Gaps = 106/715 (14%) Query: 369 NKDEKDHLIERLYREISGLK------AQLENMKTESQRVVLQLKGHVSELEADLAEQQHL 422 N D + ++ +I LK AQ N S V L S+L ++AE Q Sbjct: 570 NDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQ 629 Query: 423 -------RQQAADDCEFLRAELDELRRQR----EDTEKAQRSLSEIERKAQAN------- 464 +Q ++ E +RA L+ELR Q E+ Q+ L E E + + N Sbjct: 630 LQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQV 689 Query: 465 ----EQRYSKLKEKYSELVQNHADL-------LRKNAEVTKQVSMARQAQVDLEREKKEL 513 EQ +++++ +L + H +L R+ + +++ A+Q DL K+E Sbjct: 690 KMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ 749 Query: 514 EDSL---------------ERIS--DQGQRKTQEQLEV-LESLKQELATSQRELQVLQGS 555 ED L E +S DQ K +EQ + L++L++ + + + ++VL Sbjct: 750 EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR 809 Query: 556 LETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQL 615 TS Q +A L++E + L + E ++ L+++++D + A +E++ + Sbjct: 810 SNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKY 869 Query: 616 AKDQRKM--LLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEK 673 + R++ LV +RK ++ + + + E L + G+ +S +++ + Sbjct: 870 EGEIRQLEEALVHARKEEKEAV--SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESE 927 Query: 674 SWSQYLACPEDISG----LLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYG 729 Q ++ L +I L +D + T+ L E + L E K+ Sbjct: 928 QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTL----ELQNQLDE-YKEKN 982 Query: 730 RETLAYLASLEEEGSLENADS--TAMRNCLSKIKAIGEEL--LPRGLD-------IKQEE 778 R LA + +E +LE S TAM+ +++ + EEL R D + ++ Sbjct: 983 RRELAEMQRQLKEKTLEAEKSRLTAMK-MQDEMRLMEEELRDYQRAQDEALTKRQLLEQT 1041 Query: 779 LGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLI 838 L DL + E+ A S + + +++M K + ++ E N L L + I Sbjct: 1042 LKDL-EYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDL-----LSERISRSR 1095 Query: 839 VASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRG 898 + L+ E+++ + R + L S+ + + LVVQ Sbjct: 1096 EQMEQLRNELLQERAARQDLECDKISLERQNKDL--KSRIIHLEGSYRSSKEGLVVQMEA 1153 Query: 899 KFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958 + EL + + + + + A LQ ++R + + +V Sbjct: 1154 RIAEL------------------EDRLESEERDRANLQLSNRRLERKVKELVMQV--DDE 1193 Query: 959 QIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAG 1013 + TD D S+ L +KRQ +++ + LE+ +K +++L E + L G Sbjct: 1194 HLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQG 1248 Score = 57.0 bits (136), Expect = 9e-08 Identities = 63/276 (22%), Positives = 121/276 (43%), Gaps = 33/276 (11%) Query: 364 SQNGVNKDEKDHLIERLYREISGLKAQLENM------KTESQRVVLQLKGHVSEL--EAD 415 SQ+ +E L +RL L+ LE + + + Q + L+ +SE+ E D Sbjct: 656 SQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELD 715 Query: 416 LAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKY 475 A++ R++ A ++EL + ++D + + E E + E+ + LK Sbjct: 716 SAKRSEDREKGA--------LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGAL 767 Query: 476 SELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVL 535 E V +H + K E A + V+ + E+ S S+Q Q T+ ++++L Sbjct: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827 Query: 536 -----------ESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGA 584 E L++ +A QR+++ L+G + ++ + E +LE ++LV Sbjct: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE---EALVHAR 884 Query: 585 AHREEELS---ALRKELQDTQLKLASTEESMCQLAK 617 +E +S AL EL+ Q L+ T + QL++ Sbjct: 885 KEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSE 920 Score = 57.0 bits (136), Expect = 9e-08 Identities = 111/551 (20%), Positives = 212/551 (38%), Gaps = 76/551 (13%) Query: 317 EASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHL 376 E SS D E K+ DA Q L ++ + + N + Q+ + + L Sbjct: 770 EVSSHDQEMDKLKEQY---DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKL 826 Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436 ++ ++ G +LE + QR + LKG D A+ + ++ + L Sbjct: 827 LQEENEKLQGRSEELERRVAQLQRQIEDLKG-------DEAKAKETLKKYEGEIRQLEEA 879 Query: 437 LDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQV 496 L R++ ++ A+R+L AQ N S+ Q L K E ++Q Sbjct: 880 LVHARKEEKEAVSARRALENELEAAQGN----------LSQTTQEQKQLSEKLKEESEQK 929 Query: 497 SMARQAQVDLEREKKELEDSLERI----SDQGQRKTQEQLEVLESLKQELATSQRELQVL 552 R+ + ++E E+ L ++E++ +D + LE+ L + ++REL + Sbjct: 930 EQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEM 989 Query: 553 QGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD---TQLKLASTE 609 Q L+ LE E+ L A ++E+ + +EL+D Q + + Sbjct: 990 QRQLKEKT------------LEAEKSRLT--AMKMQDEMRLMEEELRDYQRAQDEALTKR 1035 Query: 610 ESMCQLAKD-----QRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSI 664 + + Q KD + K L R + ++D ++QL E L ++D L ++ Sbjct: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQL-EMELEEERNNSDLLSERISRS 1094 Query: 665 SSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEA 724 +EQL Q A +D+ S+ I H E Sbjct: 1095 REQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIH----------------LEG 1138 Query: 725 CKQYGRETL-----AYLASLEEEGSLENADSTAM----RNCLSKIKAIGEELLPRGLDIK 775 + +E L A +A LE+ E D + R K+K + ++ L + Sbjct: 1139 SYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT 1198 Query: 776 QEELGDLVDKEMAATSAAIETATARIEEMLS--KSRAGDTGVKLEVNERILGCCTSLMQA 833 ++ D + + A +E A I+ + S K + ++++NE + G S+ + Sbjct: 1199 DQK--DQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKD 1256 Query: 834 IQVLIVASKDL 844 +++ + SK L Sbjct: 1257 LRLKKLPSKVL 1267 >gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo sapiens] Length = 1938 Score = 70.5 bits (171), Expect = 8e-12 Identities = 116/529 (21%), Positives = 228/529 (43%), Gaps = 68/529 (12%) Query: 370 KDEKDHLIERLYR---EISGLKAQLENMKTES---QRVVLQLKGHVSELEADLAEQQHLR 423 +++K + E+L + E+S L+A++++ + S Q+ + +L+ + ELE ++ + LR Sbjct: 1074 ENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR 1133 Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483 + L EL+E+ + E+ A + E+ +K +A Q+ + E+ + + A Sbjct: 1134 AKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193 Query: 484 DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERISD--QGQRKTQEQLE--- 533 LRK AE+ +Q+ ++ + LE+EK EL+ ++ ++ + K++ +E Sbjct: 1194 ATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTC 1253 Query: 534 --VLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEEL 591 V + + A +++ Q++ A+ + E + +E++SL+S ++ L Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQ-NGELSHRVEEKESLISQLTKSKQAL 1312 Query: 592 SALRKEL-----QDTQLKLA-----STEESMCQLAKDQ-------RKMLLVGSRKAAEQV 634 + +EL ++T+ K A + C L ++Q + L KA +V Sbjct: 1313 TQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372 Query: 635 IQ-------DALNQLEE-----PPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP 682 Q DA+ + EE L A+ +T T+ S C LEK+ + Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE--NTETANSKC-ASLEKTKQRLQGEV 1429 Query: 683 EDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEE 742 ED+ L +H A L D + KQ E+ A L + ++E Sbjct: 1430 EDLMRDLER------------SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477 Query: 743 GSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIE 802 + + MRN ++ E L ++ QEE+ DL + ++A T ++ A Sbjct: 1478 SRSLSTELFKMRNAYEEVVDQLETLRRENKNL-QEEISDLTE-QIAETGKNLQEAEK--T 1533 Query: 803 EMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQV-LIVASKDLQREIVE 850 + L + D V LE E L S + +Q+ L +L R+++E Sbjct: 1534 KKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIE 1582 Score = 69.7 bits (169), Expect = 1e-11 Identities = 141/690 (20%), Positives = 271/690 (39%), Gaps = 87/690 (12%) Query: 383 EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQ----QHLRQQAADDCEFLRAELD 438 E ++ LE + + L+ ++ A+L EQ Q ++Q+ + L+ E+D Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233 Query: 439 ELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ-------NHADLLRKNAE 491 ++ + E +S S IER + E ++S++K K + Q A L +N E Sbjct: 1234 DMA---SNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGE 1290 Query: 492 VTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQV 551 ++ +V L + K+ L LE + +R+ +E+ + ++ L +S+ + + Sbjct: 1291 LSHRVEEKESLISQLTKSKQALTQQLEEL----KRQMEEETKAKNAMAHALQSSRHDCDL 1346 Query: 552 LQGSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHREEELSALRKEL-QDTQLKLA 606 L+ E +++A ++ E R + A R EEL +K+L Q Q Sbjct: 1347 LREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1406 Query: 607 STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISS 666 +TE + + A ++ +++ + ++D + LE +CA + ++ Sbjct: 1407 NTETANSKCASLEK------TKQRLQGEVEDLMRDLERSHT-ACATLDKKQRNFDKVLAE 1459 Query: 667 CIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAP----PEPADSLT 722 ++L++S ++ A ++ L + + + + + T LR E LT Sbjct: 1460 WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET--LRRENKNLQEEISDLT 1517 Query: 723 EACKQYGR--------------ETLAYLASLEE-EGSLENADSTAMRNCLSKIKAIGEEL 767 E + G+ E +LEE EGSLE+ +S +R L + E Sbjct: 1518 EQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSE-- 1575 Query: 768 LPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM-----LSKSRAGDTG---VKLEV 819 L R + K EE+ L A A A I L K GD ++L Sbjct: 1576 LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGH 1635 Query: 820 NERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYA----KNSRWTEGLISA 875 + R + ++ +Q + KD Q + ++ R KE A +N E L Sbjct: 1636 SNRQMAETQKHLRTVQGQL---KDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692 Query: 876 SKAVGWGATV-------MVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAA-------- 920 A+ ++DA+D V + L+ ++ A AQ A Sbjct: 1693 KVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQES 1752 Query: 921 --SKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNM--DFSSMTLTQI 976 ++ KA K + A + + + +A + + + +++ + + + L Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1812 Query: 977 KRQEMDSQVRVLELENELQKERQKLGELRK 1006 K+Q + RV ELENEL E+++ E K Sbjct: 1813 KKQIQKLENRVRELENELDVEQKRGAEALK 1842 Score = 64.3 bits (155), Expect = 6e-10 Identities = 145/730 (19%), Positives = 287/730 (39%), Gaps = 132/730 (18%) Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAEL 437 E + E+ K LE+ + +R + L+ ++++E + ++ + +++ L + Sbjct: 934 EEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENI 993 Query: 438 DELRRQREDTEKA-QRSLSEIE-RKAQAN---------EQRYSKLKEKYSELVQNHADLL 486 +L ++++ ++A Q++L +++ + + N EQ+ L+ + + ADL Sbjct: 994 SKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLE 1053 Query: 487 RKNAEVTKQVSMARQAQVDLEREKKELEDSLE-----------RISD------QGQRKTQ 529 R ++ + M++++ +DLE +K+++E+ L+ +I D Q Q+K + Sbjct: 1054 RAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIK 1113 Query: 530 EQLEVLESLKQELATSQ--------------RELQVLQGSLE-----TSAQSEANWAAEF 570 E +E L++E+ REL+ + LE TSAQ E N E Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKRE- 1172 Query: 571 AELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKA 630 AE +K R L E + LRK+ D+ +L +++ ++ K L + Sbjct: 1173 AEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRV-----KQKLEKEKSE 1227 Query: 631 AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLH 690 + I D + +E L + ++I +E +S+ A E + L+H Sbjct: 1228 LKMEIDDMASNIEA------------LSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275 Query: 691 SITL-LAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYL-ASLEEEGSLENA 748 + + A L + +G + E S KQ + L L +EEE +NA Sbjct: 1276 DLNMQKARLQTQ---NGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNA 1332 Query: 749 DSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDL------VDKEMAATSAAIET-ATARI 801 + A+++ +LL + +QE +L + E+A ET A R Sbjct: 1333 MAHALQSSRHDC-----DLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387 Query: 802 EEM--LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTAS-- 857 EE+ K A E E C SL + Q L +DL R++ S A+ Sbjct: 1388 EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLD 1447 Query: 858 --PKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTA 915 + F + W + L + + + + + R +EE++ Sbjct: 1448 KKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV----------- 1496 Query: 916 QLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEET-DNMDFSSMTLT 974 L L++ ++ + + + + QI ET N+ + T Sbjct: 1497 --------------DQLETLRRENKNLQEEISDLT-------EQIAETGKNLQEAEKTKK 1535 Query: 975 QIKRQEMDSQVRVLELENELQKERQKL-----------GELRKKHYELAGVAEGWEEGTE 1023 +++++ D QV + E+E L+ E K+ EL +K E E + ++ Sbjct: 1536 LVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ 1595 Query: 1024 ASPPTLQEVV 1033 + LQ V+ Sbjct: 1596 RAAEALQSVL 1605 Score = 63.5 bits (153), Expect = 1e-09 Identities = 114/679 (16%), Positives = 286/679 (42%), Gaps = 82/679 (12%) Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAE 436 +E+ ++ G Q + ++ + +R +L+G + + + + ++ +QQ + + E Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090 Query: 437 LDELRRQREDTE-----------KAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485 L +L+ + +D + + Q + E+E + +A +K++++ S+L + ++ Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI 1150 Query: 486 LRKNAE----VTKQVSMARQAQVDLEREKKELED----------SLERISDQGQRKTQEQ 531 + E + Q+ M ++ + + ++ +++LE+ +L + + EQ Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ 1210 Query: 532 LEVLESLKQELATSQRELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHR 587 ++ L+ +KQ+L + EL++ + ++E ++S++N +E + + + + Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA----K 1266 Query: 588 EEELSALRKELQDTQLKLASTEESMCQLAKDQRKML--LVGSRKAAEQVIQDALNQLEEP 645 +E+ + L +L + +L + + +++ ++ L S++A Q +++ Q+EE Sbjct: 1267 DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326 Query: 646 PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705 + H L +S C + L + + + ++ L + +A Sbjct: 1327 --TKAKNAMAHALQ--SSRHDC-DLLREQYEEEQEAKAELQRALSK-------ANSEVAQ 1374 Query: 706 GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGE 765 T + + L EA K+ + L EE N+ ++ +++ E Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQR----LQEAEENTETANSKCASLEKTKQRLQGEVE 1430 Query: 766 ELLPRGLDIKQEELGDL------VDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV 819 +L+ R L+ L DK +A ++ + A +E +SR+ T + Sbjct: 1431 DLM-RDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMR 1489 Query: 820 N--ERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASK 877 N E ++ +L + + L DL +I E+G+ ++ T+ L+ K Sbjct: 1490 NAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK--------TKKLVEQEK 1541 Query: 878 AVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQ 937 + + A V+G + EE + ++ S + KV +KD + QL++ Sbjct: 1542 S-------DLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKV-IEKDE-EIEQLKR 1592 Query: 938 ASRGVNQATAGVVASTISGKS---QIEETDNMDFSSM--TLTQIKRQEMDSQVRVLELEN 992 S+ +A V+ + I ++ ++++ D + M L RQ ++Q + ++ Sbjct: 1593 NSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG 1652 Query: 993 ELQKERQKLGELRKKHYEL 1011 +L+ + L + + + +L Sbjct: 1653 QLKDSQLHLDDALRSNEDL 1671 Score = 60.5 bits (145), Expect = 8e-09 Identities = 108/512 (21%), Positives = 204/512 (39%), Gaps = 74/512 (14%) Query: 370 KDEKDHLIERLYREISGLKAQLENMKTES-QRVVLQLKGHVSELEADLAEQQHLRQQAAD 428 ++ K L +RL + N K S ++ +L+G V +L DL E+ H D Sbjct: 1391 EEAKKKLAQRLQEAEEN--TETANSKCASLEKTKQRLQGEVEDLMRDL-ERSHTACATLD 1447 Query: 429 DCEF--------LRAELDELRRQREDTEKAQRSLS-----------EIERKAQANEQRYS 469 + + +LDE + + E +K RSLS E+ + + + Sbjct: 1448 KKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENK 1507 Query: 470 KLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLE----------- 518 L+E+ S+L + A+ + E K + Q + DL+ +E+E SLE Sbjct: 1508 NLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL 1567 Query: 519 ---RISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQS-------EANWAA 568 ++ + RK E+ E +E LK+ SQR + LQ L+ +S + Sbjct: 1568 ELSQVKSELDRKVIEKDEEIEQLKR---NSQRAAEALQSVLDAEIRSRNDALRLKKKMEG 1624 Query: 569 EFAELEKERDSLVSGAAHREEELSALRKELQDTQL----KLASTEESMCQLA-KDQRKML 623 + E+E + A ++ L ++ +L+D+QL L S E+ QLA ++R L Sbjct: 1625 DLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGL 1684 Query: 624 LVGSRKAAEQVIQ--DALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681 L+ + + ++ + +L E L+ + L S TS+ + ++LE +Q C Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQ---C 1741 Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSL-TEACKQYGRETLAYLASLE 740 ++ + AI A E S E K+ +T+ L Sbjct: 1742 QAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL---- 1797 Query: 741 EEGSLENADSTAMRNCLSKIKAIGEEL--LPRGLDIKQEELGDLVD---------KEMAA 789 + L+ A+ A++ +I+ + + L LD++Q+ + + KEM Sbjct: 1798 -QHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTY 1856 Query: 790 TSAAIETATARIEEMLSKSRAGDTGVKLEVNE 821 + R+++++ K +A K + E Sbjct: 1857 QAEEDHKNILRLQDLVDKLQAKVKSYKRQAEE 1888 Score = 49.7 bits (117), Expect = 1e-05 Identities = 54/249 (21%), Positives = 114/249 (45%), Gaps = 27/249 (10%) Query: 382 REISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELR 441 +E++ +K E K E R + K ++ + L E+ L+ Q +++E + L Sbjct: 851 KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQ-------VQSETENLM 903 Query: 442 RQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQ 501 E E +S +E K + +R + +E SELV +L K + + + + Sbjct: 904 DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963 Query: 502 AQVDLEREKKELEDSLERISDQG-------QRKTQEQLEVLESLKQELATSQRELQVLQG 554 +E+EK E+ ++ +S++ + T+E+ + E+ +Q L Q E + G Sbjct: 964 TLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNG 1023 Query: 555 SLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSA-LRKELQDTQLKLASTEESMC 613 ++ + A+LE++ D L G+ +E++L A L + + + L ++ES+ Sbjct: 1024 LIKIN-----------AKLEQQTDDL-EGSLEQEKKLRADLERAKRKLEGDLKMSQESIM 1071 Query: 614 QLAKDQRKM 622 L D++++ Sbjct: 1072 DLENDKQQI 1080 >gi|16262452 cingulin [Homo sapiens] Length = 1203 Score = 69.7 bits (169), Expect = 1e-11 Identities = 143/669 (21%), Positives = 266/669 (39%), Gaps = 75/669 (11%) Query: 373 KDHLIER-LYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQ-QHLRQQAADDC 430 KD L R L E+ K ++E +R + LKG + E A ++ +H+RQQ D Sbjct: 467 KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526 Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490 E LR + + + E ++ +S + R Q + S+ + + Q + + LR Sbjct: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586 Query: 491 EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQ 550 + Q+ M ++ ++E E E + L+R +Q + + +V E LK+EL +Q EL+ Sbjct: 587 QELLQLRMEKE---EMEEELGEKIEVLQRELEQARASAGDTRQV-EVLKKELLRTQEELK 642 Query: 551 VLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDT--QLKLAST 608 LQ E +Q A + ELEK+ +++ A R EL +LQ T QL+ Sbjct: 643 ELQA--ERQSQEVAGRHRD-RELEKQL-AVLRVEADRGRELEEQNLQLQKTLQQLRQDCE 698 Query: 609 EESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLE---------EPPLISCAGSADHLLS 659 E S ++ + +L R A E +++ + + E L G D + Sbjct: 699 EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEA 758 Query: 660 TVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPAD 719 + +++LE Q L A + A L A E A Sbjct: 759 VEARLRDKLQRLEAEKQQL------------EEALNASQEEEGSLAAAKRALEARLEEAQ 806 Query: 720 SLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEEL 779 + G+E +LEEEG R L + KA EE R LD + L Sbjct: 807 ---RGLARLGQEQQTLNRALEEEGK--------QREVLRRGKAELEE-QKRLLDRTVDRL 854 Query: 780 GDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN------ERILGCCTSLMQA 833 ++K + A++ A++E+ K+R + + E+ G + L Sbjct: 855 NKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDE 914 Query: 834 IQVLIVASKDLQRE-----------------IVESGRGTASPKEFYAKNSRWTEGLISAS 876 IQ L A + Q E + + ++ A+ + E +S Sbjct: 915 IQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRL 974 Query: 877 KA-VGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQL 935 + + + D V +GR + ++L + S Q + K+ ++ + +L Sbjct: 975 ETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQ-ERSARQDLECDKISLERQNKDLKTR 1033 Query: 936 QQASRGVNQATAGVVASTISGKSQ-IEETDNMDFSSMTLTQIKRQEMDSQVRVLELENEL 994 +S G + +A + S + ++Q ++E + T+ Q ++++ +V+ EL ++ Sbjct: 1034 LASSEGFQKPSASL--SQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVK--ELSIQI 1089 Query: 995 QKERQKLGE 1003 + ERQ + + Sbjct: 1090 EDERQHVND 1098 Score = 56.2 bits (134), Expect = 2e-07 Identities = 56/219 (25%), Positives = 95/219 (43%), Gaps = 48/219 (21%) Query: 378 ERLYREISGLKAQLENMKTESQRVVLQLKG---HVSELEADLAEQQHLRQ-------QAA 427 E L + + GL+ + EN K QLKG VS LE +L E+++ + + Sbjct: 937 ELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGR 996 Query: 428 DDCEFLRAELDELRRQREDTE------------------------KAQRSLSEIERKAQA 463 D + LR EL + R R+D E K SLS++E + Q Sbjct: 997 DQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056 Query: 464 NEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVD-----------LEREKKE 512 ++R + + + L + L RK E++ Q+ RQ D L+R+ E Sbjct: 1057 LQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDE 1116 Query: 513 LEDSLERISD---QGQRKTQEQLEVLESLKQELATSQRE 548 E+ +ER+ + QR+ +EQ EV E L+ + + +++ Sbjct: 1117 AEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKD 1155 Score = 55.8 bits (133), Expect = 2e-07 Identities = 71/341 (20%), Positives = 136/341 (39%), Gaps = 28/341 (8%) Query: 328 EKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGL 387 E ++ + Q++F +D+ + + + ++E IE L RE+ Sbjct: 560 ELEETSEETGHWQSMFQKNKEDLRATK--QELLQLRMEKEEMEEELGEKIEVLQRELEQA 617 Query: 388 KA------QLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDE-- 439 +A Q+E +K E R +LK +E ++ +H ++ LR E D Sbjct: 618 RASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGR 677 Query: 440 ------------LRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLR 487 L++ R+D E+A ++ E +A QR + ++ E + + + R Sbjct: 678 ELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR 737 Query: 488 KNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547 + + +Q+ R E + L D L+R+ + Q + +E L + + LA ++R Sbjct: 738 RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ-QLEEALNASQEEEGSLAAAKR 796 Query: 548 ELQV----LQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQL 603 L+ Q L Q + E K+R+ L G A EE+ L + + Sbjct: 797 ALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNK 856 Query: 604 KLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEE 644 +L E Q A Q + L ++ A + + DA Q ++ Sbjct: 857 ELEKIGEDSKQ-ALQQLQAQLEDYKEKARREVADAQRQAKD 896 Score = 44.7 bits (104), Expect = 5e-04 Identities = 138/672 (20%), Positives = 250/672 (37%), Gaps = 109/672 (16%) Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDC 430 DE+ ++L GL+ QLE KTE S L+ L ++ QQ+ + Sbjct: 376 DEEVKKRQKLEPSQVGLERQLEE-KTEE----------CSRLQELLERRKGEAQQSNKEL 424 Query: 431 EFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA 490 + ++ LD+ R E L + Q E L + E + ++L Sbjct: 425 QNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQ 484 Query: 491 EVTKQVSMARQAQVDLEREKKE----LEDSLERISDQGQRKTQEQLEVLESLKQELATSQ 546 V +Q+ + + L+ KE + +E + Q QR T++ ++ Q+ A + Sbjct: 485 RVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLE 544 Query: 547 RELQV-------LQGSLETSAQSEANWAAEF----AELEKERDSLVSGAAHRE------- 588 E Q LQ LE +++ +W + F +L + L+ +E Sbjct: 545 AERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG 604 Query: 589 EELSALRKELQDTQLKLAST---EESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEP 645 E++ L++EL+ + T E +L + Q ++ + + + +++V ++ E Sbjct: 605 EKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEK 664 Query: 646 PLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH 705 L AD + QL+K+ Q E+ S ++A + + Sbjct: 665 QLAVLRVEADR----GRELEEQNLQLQKTLQQLRQDCEEAS----KAKMVAEAEATVLGQ 716 Query: 706 ---GATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLEN---ADSTAMRNCLSK 759 T LR E D ++ R L L+E L + A +R+ L + Sbjct: 717 RRAAVETTLRETQEEND-------EFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR 769 Query: 760 IKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEV 819 ++A ++ L L+ QEE G L AA A+E AR+EE ++ G + + Sbjct: 770 LEA-EKQQLEEALNASQEEEGSL-----AAAKRALE---ARLEE--AQRGLARLGQEQQT 818 Query: 820 NERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAV 879 R L + QRE++ RG A +E R + L + + Sbjct: 819 LNRAL---------------EEEGKQREVLR--RGKAELEEQKRLLDRTVDRLNKELEKI 861 Query: 880 GWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQ--- 936 G D+ + Q + + E+ + A + +A+K S L++LQ Sbjct: 862 G------EDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915 Query: 937 ----------QASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVR 986 QA R + ++A + G Q E +N S RQ + + Sbjct: 916 QRLRQALQASQAERDTARLDKELLAQRLQGLEQ--EAENKKRSQ---DDRARQLKGLEEK 970 Query: 987 VLELENELQKER 998 V LE EL +E+ Sbjct: 971 VSRLETELDEEK 982 Score = 41.6 bits (96), Expect = 0.004 Identities = 128/603 (21%), Positives = 224/603 (37%), Gaps = 94/603 (15%) Query: 477 ELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLE 536 EL + +L RK E K+ +QV LER+ +E + R+ E+LE Sbjct: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQ-----------ELLE 411 Query: 537 SLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRK 596 K E S +ELQ ++ L+ + EL+ + + +E L K Sbjct: 412 RRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKE----VLLK 467 Query: 597 ELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGS-AD 655 +L +T ++ + +L G ++ EQ+ +L E L + G+ + Sbjct: 468 DLLET---------------RELLEEVLEGKQRVEEQL------RLRERELTALKGALKE 506 Query: 656 HLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPP 715 + S + +Q ++ Q +D + H++ A+ G L Sbjct: 507 EVASRDQEVEHVRQQYQRDTEQLRRSMQDAT-QDHAVLEAERQKMSALVRGLQRELEETS 565 Query: 716 EPA---DSLTEACKQYGRETLAYLASL-----EEEGSLENADSTAMRNCLSKIKAIGE-- 765 E S+ + K+ R T L L E E L R + G+ Sbjct: 566 EETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTR 625 Query: 766 --ELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRA-----GDTGVKLE 818 E+L + L QEEL KE+ A + E A + L K A D G +LE Sbjct: 626 QVEVLKKELLRTQEEL-----KELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELE 680 Query: 819 VNERILGCCTSLMQAIQVLIVASKD---LQREIVESGRGTASP----KEFYAKNSRW--- 868 E+ L +L Q Q ASK + E G+ A+ +E +N + Sbjct: 681 --EQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRR 738 Query: 869 ----------TEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLV 918 T GL+ +AV + D + + + EE + S E S A Sbjct: 739 ILGLEQQLKETRGLVDGGEAV---EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK 795 Query: 919 AASKVKADKDSPNLAQLQQASRGVNQA--TAGVVASTI-SGKSQIEETDNM-----DFSS 970 A + + ++ LA+L Q + +N+A G + GK+++EE + D + Sbjct: 796 RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN 855 Query: 971 MTLTQIKRQEMDS-QVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTL 1029 L +I + Q +LE+ +K R+++ + +++ + A AE G + Sbjct: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915 Query: 1030 QEV 1032 Q + Sbjct: 916 QRL 918 Score = 36.2 bits (82), Expect = 0.16 Identities = 76/348 (21%), Positives = 135/348 (38%), Gaps = 40/348 (11%) Query: 145 LLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLE-CELNLFQTVF 203 L R K E + + +++L++ GE QL ++ DY E + Sbjct: 833 LRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQR 892 Query: 204 NSLDMSRSVSVTAAGQCRLAPLIQVI---LDCSHLYDYTVKLLFKLHSCLPADTLQGHRD 260 + D + T+ G RL IQ + L S T +L L A LQG Sbjct: 893 QAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTA----RLDKELLAQRLQG--- 945 Query: 261 RFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASS 320 +EQ + K RS + R Q+ L E + L E + V ++ + Sbjct: 946 --LEQEAENKK---RSQD----DRARQLKGLEEKVSRL--ETELDEEKNTVELLTDRVNR 994 Query: 321 PDSEPVLEKDDLMDMDASQQNLFDNKFD------DIFGSSFSSDPFNFNSQNGVNKDEKD 374 + + +LM +++Q+L +K D+ SS+ F S + + ++ Sbjct: 995 GRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQN 1054 Query: 375 HLI-ERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFL 433 L+ ERL E E KT Q +L+ V EL + ++ RQ D + L Sbjct: 1055 QLLQERLQAE--------EREKTVLQSTNRKLERKVKELSIQIEDE---RQHVNDQKDQL 1103 Query: 434 RAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQN 481 + L+RQ ++ E+ L + +KAQ + ++ E+ +++ Sbjct: 1104 SLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKS 1151 >gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens] Length = 284 Score = 68.9 bits (167), Expect = 2e-11 Identities = 74/297 (24%), Positives = 131/297 (44%), Gaps = 42/297 (14%) Query: 326 VLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYR-EI 384 +L+ D +D ++Q D K + D V++DE+D ++E L++ E Sbjct: 10 MLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAED 69 Query: 385 SGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQR 444 S L A+ K E+ L + + E E D A+++ L L +L Sbjct: 70 SLLAAEEAAAKAEADVASLNRRIQLVEEELDRAQER------------LATALQKLEEAE 117 Query: 445 EDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQV 504 + ++++R + IE +AQ +E++ + + E D RK EV +++ + Sbjct: 118 KAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIES--- 174 Query: 505 DLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQ-----------RELQVLQ 553 DLER ++ E +S+ R+ +EQL +++ + L ++ E++VL Sbjct: 175 DLERAEERAE-----LSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLS 229 Query: 554 GSLETSAQSEANWAAEFAE-----LEKERDSLVSGAAHREEELSALRKELQDTQLKL 605 L+ EA AEFAE LEK D L AH +EE ++ + L T L+L Sbjct: 230 DKLK-----EAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLEL 281 >gi|4504063 golgin 97 [Homo sapiens] Length = 767 Score = 68.9 bits (167), Expect = 2e-11 Identities = 129/601 (21%), Positives = 244/601 (40%), Gaps = 86/601 (14%) Query: 483 ADLLRKNAEVTK---QVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLK 539 + LLR+N ++ K ++S + +L++ K++LE +LE+ D RK QEQ E ++ + Sbjct: 58 SQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANR 117 Query: 540 QELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVS----------GAAHREE 589 ++A +G A+ + W+ + +LEKE++ L + R + Sbjct: 118 AKMA---------EGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRD 168 Query: 590 ELSAL----RKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAE-----QVIQDALN 640 E+ L ++EL + L EES+ ++ ++ SR E Q+ D Sbjct: 169 EMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQ 228 Query: 641 QLEEPP--LISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHL 698 +LEE + DH++++ T S I LE+ + A + +S L +T Sbjct: 229 KLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQE 288 Query: 699 TSDAIAH--GATTCLRAPPEPADSLTEACKQYGRE-TLA----------YLASLEEEGSL 745 D I H L E S E ++ +E TLA LA+ + Sbjct: 289 KEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKA 348 Query: 746 ENADSTAMRNCLSKIKAIGEELLP-RGLDIKQE-----------ELGDLVDKEMAATSAA 793 N T +R ++A E+L +G+ QE E + + +A Sbjct: 349 INTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQF 408 Query: 794 IETATARIEEM--LSKSRAGDT-----GVKL--EVNERILGCCTSLMQAIQVLIVASKDL 844 +E A ++ L ++RA D G++ + N + C +++Q K L Sbjct: 409 LERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKL 468 Query: 845 -----QREIVESGRGTA------SPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLV 893 QREIV A +EF + + T + + + V++ + Sbjct: 469 KEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEI 528 Query: 894 VQGRGKFEELMVCSHEIAAS-----TAQLVAASKVKADKDSPNL-AQLQQASRGVNQA-- 945 +Q ++ H++ A T + A+ V +D L LQ + VN++ Sbjct: 529 LQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHV 588 Query: 946 TAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELR 1005 T+ + + T N + +M LTQ+++++ D + ++LE +++ +Q++ ELR Sbjct: 589 TSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELR 648 Query: 1006 K 1006 K Sbjct: 649 K 649 Score = 56.2 bits (134), Expect = 2e-07 Identities = 57/220 (25%), Positives = 103/220 (46%), Gaps = 26/220 (11%) Query: 377 IERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAA-------DD 429 +E RE+ E +S+ +V + + EL A E H++QQA + Sbjct: 352 LETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLER 411 Query: 430 CEFLRAELDELRRQRE-DTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRK 488 + L A++ L R R D A++ + ++E++ A ++ + +Y +QNH L+K Sbjct: 412 TQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKE----CRNEYERSLQNHQFELKK 467 Query: 489 NAEVTKQ---VSMA-RQAQVDLEREKKELED---SLERISDQGQRKTQEQLEVLESLKQE 541 E Q VS+A QA ++ ++++E + +L I D+ ++ +E+ EVL +QE Sbjct: 468 LKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQE 527 Query: 542 LATSQR-------ELQVLQGSLETSAQSEANWAAEFAELE 574 + +R ++ LQ LE +A AA AE E Sbjct: 528 ILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQE 567 Score = 55.5 bits (132), Expect = 3e-07 Identities = 69/319 (21%), Positives = 136/319 (42%), Gaps = 22/319 (6%) Query: 370 KDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADD 429 +DE D L +E+S +K L + ++ +L+ EL E + Q ++D Sbjct: 167 RDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSD- 225 Query: 430 CEFLRAELDELRRQREDTEKAQ----RSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485 L +L+EL+R E+ + S + E K A EQ+ +L+ +L DL Sbjct: 226 ---LSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQL---SIDL 279 Query: 486 LRKNAEVTKQVSMARQAQVDLEREKKELEDSL---ERISDQGQRKTQEQLEVLESLKQEL 542 + AE ++ + Q + +K LE +L E + + + KT + + LE +Q+L Sbjct: 280 QKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAE-QNLEDTRQQL 338 Query: 543 ATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ 602 ++ +LET + E ++ +V+ + +EL+A +E Q Sbjct: 339 LAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQ 398 Query: 603 LKLASTEESMCQ--LAKDQRKMLLVGSRKAAEQVIQDALNQLEE--PPLISCAGSADHLL 658 + + E+ + A + + + L +R A + + + QLE+ L C + L Sbjct: 399 QQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSL 458 Query: 659 STVTSISSCIEQLEKSWSQ 677 + +++L++ WSQ Sbjct: 459 Q---NHQFELKKLKEEWSQ 474 Score = 42.0 bits (97), Expect = 0.003 Identities = 53/266 (19%), Positives = 114/266 (42%), Gaps = 17/266 (6%) Query: 371 DEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEA----DLAEQQHLRQQA 426 ++K+ ++ L +++S ++ E + V+ L+ V+ LE +L+ ++H+ Q+ Sbjct: 262 EQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHV-QEL 320 Query: 427 ADDCEFLRAELDELRRQ----REDTEKAQRSLS----EIERKAQANEQRYSKLKEKYSEL 478 + L++ R+Q R KA +L E+E+ QA+E++ + K + Sbjct: 321 LKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKG----I 376 Query: 479 VQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESL 538 V +++ A ++ S +Q + LE++ E +LE +R E Sbjct: 377 VAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQG 436 Query: 539 KQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKEL 598 ++L L+ + E S Q+ + E +R+ + A EE+ R+E Sbjct: 437 MRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEF 496 Query: 599 QDTQLKLASTEESMCQLAKDQRKMLL 624 Q L + + Q +++ ++LL Sbjct: 497 QQQAANLTAIIDEKEQNLREKTEVLL 522 Score = 35.4 bits (80), Expect = 0.28 Identities = 40/201 (19%), Positives = 83/201 (41%), Gaps = 41/201 (20%) Query: 382 REISGLKAQLENMKTE-SQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDEL 440 R + + +L+ +K E SQR ++ + LE +++ +QQAA+ + + L Sbjct: 456 RSLQNHQFELKKLKEEWSQREIVSV-AMAQALEEVRKQREEFQQQAANLTAIIDEKEQNL 514 Query: 441 RRQREDTEKAQRSLSEIER----------KAQANEQRYSKLKEKYSELVQNHADLLRKNA 490 R + E + ++ + ++ER + QA + LK + + +V DLLR Sbjct: 515 REKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRG 574 Query: 491 EVTKQVSMARQAQV-----------------------------DLEREKKELEDSLERIS 521 + + ++ V L++EK++LE L + Sbjct: 575 PLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKN 634 Query: 522 DQGQRKTQEQLEVLESLKQEL 542 ++ Q LE+ ++L++EL Sbjct: 635 KTIKQMQQRMLELRKTLQKEL 655 >gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo sapiens] Length = 1935 Score = 68.6 bits (166), Expect = 3e-11 Identities = 140/688 (20%), Positives = 277/688 (40%), Gaps = 89/688 (12%) Query: 383 EISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQ----QHLRQQAADDCEFLRAELD 438 E ++ LE + + L+ ++ A+L EQ Q ++Q+ + + ELD Sbjct: 1170 EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD 1229 Query: 439 ELRRQREDTEKAQRSLSEIER--KAQANEQRYSKLKE---KYSELVQNHADLLRKNAEVT 493 ++ E KA+ +L ++ R + Q NE R SK +E ++L A L +N E++ Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHR-SKAEETQRSVNDLTSQRAKLQTENGELS 1288 Query: 494 KQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQ 553 +Q+ L R K LE + +R+ +E+++ +L L +++ + +L+ Sbjct: 1289 RQLDEKEALISQLTRGKLTYTQQLEDL----KRQLEEEVKAKNALAHALQSARHDCDLLR 1344 Query: 554 GSLETSAQSEANWAAEFAELEKE----RDSLVSGAAHREEELSALRKELQDTQLKLASTE 609 E +++A ++ E R + A R EEL +K+L +L E Sbjct: 1345 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ---RLQEAE 1401 Query: 610 ESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSI-SSCI 668 E++ A + + L ++ + I+D + +E + A + D I + Sbjct: 1402 EAV--EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN--AAAAALDKKQRNFDKILAEWK 1457 Query: 669 EQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAH----------------GATTCLR 712 ++ E+S S+ + ++ L + L + +++ H T L Sbjct: 1458 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517 Query: 713 APPEPADSLTEACKQYGRETLAYLASLEE-EGSLENADSTAMRNCL--SKIKA-IGEELL 768 + + L + KQ E + ++LEE E SLE+ + +R L ++IKA I +L Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1577 Query: 769 PRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTG---VKLEVNERILG 825 + +++Q + L + TS ET + + K GD ++L R+ Sbjct: 1578 EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAA 1637 Query: 826 CCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATV 885 ++++Q L+ KD Q ++ ++ R KE A R L+ A Sbjct: 1638 EAQKQVKSLQSLL---KDTQIQLDDAVRANDDLKENIAIVER-RNNLLQAELEELRAVVE 1693 Query: 886 MVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQ--------Q 937 + + + + +EL+ S + +Q + K D+ +L+QLQ + Sbjct: 1694 QTERSRKLAE-----QELIETSERVQLLHSQNTSLINQKKKMDA-DLSQLQTEVEEAVQE 1747 Query: 938 ASRGVNQATAGVVASTISGKSQIEETD----------NMDFS------------SMTLTQ 975 +A + + + + +E D NM+ + + L Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1807 Query: 976 IKRQEMDSQVRVLELENELQKERQKLGE 1003 K+Q + RV ELENEL+ E+++ E Sbjct: 1808 GKKQLQKLEARVRELENELEAEQKRNAE 1835 Score = 61.6 bits (148), Expect = 4e-09 Identities = 104/509 (20%), Positives = 214/509 (42%), Gaps = 68/509 (13%) Query: 370 KDEKDHLIERLYR---EISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLR 423 +++K L ERL + E++ L A++E+ + ++ Q+ + +L+ + ELE +L ++ R Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129 Query: 424 QQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHA 483 + L EL+E+ + E+ A E+ +K +A Q+ + E+ + + A Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1189 Query: 484 DLLRKN-----AEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQR--KTQEQLE-VL 535 LRK AE+ +Q+ ++ + LE+EK E + L+ ++ ++ K + LE + Sbjct: 1190 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMC 1249 Query: 536 ESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEK---ERDSLVS----GAAHRE 588 +L+ ++ + + + Q S+ A E EL + E+++L+S G Sbjct: 1250 RTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT 1309 Query: 589 EELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLI 648 ++L L+++L++ ++K + Q A+ +L EQ ++ + E ++ Sbjct: 1310 QQLEDLKRQLEE-EVKAKNALAHALQSARHDCDLL-------REQYEEETEAKAELQRVL 1361 Query: 649 SCAGSADHLLSTVTSISSC-----IEQLEKSWSQYLACPED----ISGLLHSITLLAHLT 699 S A S T + +E+ +K +Q L E+ ++ S+ H Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRL 1421 Query: 700 SDAI---------AHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEG------- 743 + I ++ A L D + KQ E+ + L S ++E Sbjct: 1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481 Query: 744 -SLENADSTAM----------RNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSA 792 L+NA ++ +N +I + E+L G I + E V K++ A Sbjct: 1482 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE---KVRKQLEAEKM 1538 Query: 793 AIETATARIEEMLSKSRAGDTGVKLEVNE 821 +++A E L +LE N+ Sbjct: 1539 ELQSALEEAEASLEHEEGKILRAQLEFNQ 1567 Score = 60.8 bits (146), Expect = 6e-09 Identities = 121/565 (21%), Positives = 232/565 (41%), Gaps = 72/565 (12%) Query: 240 VKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFL 299 +KL FK+ L + + E+FT+LK+ +S + + L E L Sbjct: 830 MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL 889 Query: 300 RASALSEHISPVV---------VIPAEASSPDSEPVLEKDDLM--DMDASQQNLFD---- 344 + A ++++ I EA + LE ++ M ++ A ++ L D Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 949 Query: 345 --NKFDDIFGSSFSSDPFNFNSQNGV-NKDEK----DHLIERLYREISGL----KAQLEN 393 DD+ + + ++N V N E+ D +I +L +E L + L++ Sbjct: 950 LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1009 Query: 394 MKTESQRV------VLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDT 447 ++ E +V ++L+ V +LE L +++ +R L +L + D Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069 Query: 448 EKAQRSLSEIERK----AQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQ 503 E ++ L E +K A R + S+L + +L + E+ +++ R A+ Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129 Query: 504 VDLEREKKELEDSLERISDQGQR---KTQEQLEVLESLKQELATSQRELQVLQGSLE--- 557 +E+ + +L LE IS++ + T Q+E+ + + E +R+L+ + +L+ Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE--EATLQHEA 1187 Query: 558 TSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQ------LKLASTEES 611 T+A A AEL ++ D+L E+E S + EL D +K + E Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK 1247 Query: 612 MCQLAKDQRKMLLVGSRKAAEQVIQDALNQL--EEPPLISCAGSADHLLSTVTSISSCIE 669 MC+ +DQ + ++ + Q ++N L + L + G L ++ S + Sbjct: 1248 MCRTLEDQ-----MNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1302 Query: 670 QLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYG 729 + + +++Q L ED+ L +A+AH L++ D L E QY Sbjct: 1303 RGKLTYTQQL---EDLKRQLEEEV----KAKNALAH----ALQSARHDCDLLRE---QYE 1348 Query: 730 RETLAYLASLEEEGSLENADSTAMR 754 ET A A L+ S N++ R Sbjct: 1349 EETEA-KAELQRVLSKANSEVAQWR 1372 Score = 56.6 bits (135), Expect = 1e-07 Identities = 114/594 (19%), Positives = 237/594 (39%), Gaps = 89/594 (14%) Query: 460 KAQANEQRYSKLKEKYSELVQ--NHADLLRKNAEVTKQVSMARQ---AQVDLEREKKELE 514 K+ E+ + +KE+++ L + ++ RK E K VS+ ++ Q+ ++ E+ L Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELE-EKMVSLLQEKNDLQLQVQAEQDNLA 899 Query: 515 DSLERISDQGQRKTQ---------EQLEVLESLKQELATSQRELQVLQGSLETSAQSEAN 565 D+ ER + K Q E+LE E + EL +R+L+ Sbjct: 900 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE--------------- 944 Query: 566 WAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLV 625 E +EL+++ D L A E+E A ++++ ++A +E + +L K+ Sbjct: 945 --DECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE------- 995 Query: 626 GSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685 +KA ++ Q AL+ L+ + L + ++ LE S Q D+ Sbjct: 996 --KKALQEAHQQALDDLQAE-----EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDL 1048 Query: 686 SGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSL 745 + LT ++I L E K+ E A A +E+E +L Sbjct: 1049 ERAKRKLEGDLKLTQESIMD--------LENDKQQLDERLKKKDFELNALNARIEDEQAL 1100 Query: 746 ENADSTAMRNCLSKIKAIGEEL-LPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEM 804 + ++ ++I+ + EEL R K E+L + +E+ S +E A Sbjct: 1101 GSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA------- 1153 Query: 805 LSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAK 864 G T V++E+N++ + Q ++ +DL+ ++ A+ ++ +A Sbjct: 1154 -----GGATSVQIEMNKK----REAEFQKMR------RDLEEATLQHEATAAALRKKHA- 1197 Query: 865 NSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVK 924 + + + + V + + + +++ +I + A L + Sbjct: 1198 -----DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252 Query: 925 ADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIK---RQEM 981 D+ + + ++ ++ R VN T+ + D + LT+ K Q++ Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312 Query: 982 DSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTE 1035 + R +LE E++ + L+ ++ + E +EE TEA LQ V+++ Sbjct: 1313 EDLKR--QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAK-AELQRVLSK 1363 Score = 55.5 bits (132), Expect = 3e-07 Identities = 127/695 (18%), Positives = 265/695 (38%), Gaps = 84/695 (12%) Query: 387 LKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQRED 446 ++A+ +N+ +R +K + +LEA + E + +D E + AEL +R+ ED Sbjct: 891 VQAEQDNLADAEERCDQLIKNKI-QLEAKVKEMN----ERLEDEEEMNAELTAKKRKLED 945 Query: 447 T-EKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVD 505 + +R + ++E E+ + K L + A L A++TK+ ++A Sbjct: 946 ECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1005 Query: 506 LEREKKELEDSLERISDQGQRKTQEQLEVLE-SLKQELATS---QRELQVLQGSLETSAQ 561 + + ED + ++ + + K ++Q++ LE SL+QE +R + L+G L+ + + Sbjct: 1006 ALDDLQAEEDKVNTLT-KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064 Query: 562 SEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRK 621 S +LE ++ L ++ EL+AL ++D Q + ++ + +L Q + Sbjct: 1065 S-------IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL---QAR 1114 Query: 622 MLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLAC 681 + + AE+ + + +L ++ L + S IE +K +++ Sbjct: 1115 IEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKM 1174 Query: 682 PEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEE 741 D L TL T+ A+ + E D+L ++ +E + L++ Sbjct: 1175 RRD----LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD 1230 Query: 742 EGSLENADSTAMRNCLSKIKAIGEEL------------------------------LPRG 771 S A N + + +++ L R Sbjct: 1231 VTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ 1290 Query: 772 LDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLM 831 LD K+ + L ++ T +E ++EE + A ++ ++ C L Sbjct: 1291 LDEKEALISQLTRGKLTYTQ-QLEDLKRQLEEEVKAKNALAHALQSARHD-----CDLLR 1344 Query: 832 QAIQVLIVASKDLQREIVESGRGTASPKEFYAKNS-RWTEGLISASKAVGWGATVMVDAA 890 + + A +LQR + ++ A + Y ++ + TE L A K + A + +A Sbjct: 1345 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL---AQRLQEAE 1401 Query: 891 DLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVV 950 + V K L H + L+ V ++ + A L + R ++ A Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLM----VDVERSNAAAAALDKKQRNFDKILAEWK 1457 Query: 951 ASTISGKSQIEETDNMDFSSMT---------------LTQIKRQEMDSQVRVLELENELQ 995 +S++E + S T L KR+ + Q + +L +L Sbjct: 1458 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517 Query: 996 KERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQ 1030 + + EL K +L + E + +L+ Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLE 1552 Score = 46.2 bits (108), Expect = 2e-04 Identities = 117/663 (17%), Positives = 264/663 (39%), Gaps = 67/663 (10%) Query: 397 ESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSE 456 E ++ + +K + L+ L + + R++ + L E ++L+ Q + Q +L++ Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQ---VQAEQDNLAD 900 Query: 457 IERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDS 516 E + + +L+ K E+ + D NAE+T + +L+R+ +LE + Sbjct: 901 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELT 960 Query: 517 LERISDQ---GQRKTQEQLEVLESLKQELATSQRELQVLQGSLETS---AQSEANWAAEF 570 L ++ + + K + E + L + +A +E + LQ + + + Q+E + Sbjct: 961 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1020 Query: 571 AELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS----TEESMCQLAKDQRKMLLVG 626 + + + + V E+ +R +L+ + KL T+ES+ L D++++ Sbjct: 1021 TKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL---D 1077 Query: 627 SRKAAEQVIQDALN-QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDI 685 R + +ALN ++E+ + L + + + IE+LE+ + Sbjct: 1078 ERLKKKDFELNALNARIEDEQAL-----GSQLQKKLKELQARIEELEEELEAERTARAKV 1132 Query: 686 SGLLHSITLLAHLTSDAI--AHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEG 743 L ++ S+ + A GAT+ + ++ + ++ E A+L+ E Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE-----ATLQHEA 1187 Query: 744 SL-----ENADSTA-MRNCLSKIKAIGEELLPRGLDIKQEELGDLVD--KEMAATSAAIE 795 + ++ADS A + + ++ + ++L + K EL D+ +++ A +E Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL-ELDDVTSNMEQIIKAKANLE 1246 Query: 796 TATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVES---- 851 +E+ +++ R+ K E +R + TS +Q + +L R++ E Sbjct: 1247 KMCRTLEDQMNEHRS-----KAEETQRSVNDLTSQRAKLQ---TENGELSRQLDEKEALI 1298 Query: 852 ---GRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSH 908 RG + + R E + A A+ DL+ + + E Sbjct: 1299 SQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1358 Query: 909 EIAASTAQLVAASKVKADKDS-PNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMD 967 + + VA + K + D+ +L++A + +A + + E N Sbjct: 1359 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKK--------KLAQRLQEAEEAVEAVNAK 1410 Query: 968 FSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPP 1027 SS+ T+ + Q + +L ++++ L KK + W++ E S Sbjct: 1411 CSSLEKTKHRLQN-----EIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465 Query: 1028 TLQ 1030 L+ Sbjct: 1466 ELE 1468 Score = 39.3 bits (90), Expect = 0.019 Identities = 68/324 (20%), Positives = 128/324 (39%), Gaps = 70/324 (21%) Query: 369 NKDEKDHLIERLYREISGLKAQLEN---MKTESQRVVLQLKGHVSELEADLAEQQHLRQQ 425 +++E + +++ +++ ++ QL + M E+Q+ V L+ + + + L + Sbjct: 1607 SRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD 1666 Query: 426 AADDC-------EFLRAELDELRRQREDTEK----AQRSLSEIERKAQANEQRYSKLKEK 474 ++ L+AEL+ELR E TE+ A++ L E + Q + + L + Sbjct: 1667 LKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1726 Query: 475 YSELVQNHADLLRKNAEVTKQVSMARQAQ------------------------VDLEREK 510 ++ ADL + EV + V R A+ LER K Sbjct: 1727 KKKM---DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1783 Query: 511 KELE----------DSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSA 560 K +E D E+I+ +G +K QL+ LE+ +E L+ LE Sbjct: 1784 KNMEQTIKDLQHRLDEAEQIALKGGKK---QLQKLEARVRE----------LENELEAEQ 1830 Query: 561 QSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQR 620 + A + E+ L + L L+ + QLK+ + + + A++Q Sbjct: 1831 KRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKR-QAEEAEEQA 1889 Query: 621 KMLLVGSRKAAEQVIQDALNQLEE 644 L RK +Q L++ EE Sbjct: 1890 NTNLSKFRK-----VQHELDEAEE 1908 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.128 0.352 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 35,456,158 Number of Sequences: 37866 Number of extensions: 1530778 Number of successful extensions: 14042 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 352 Number of HSP's successfully gapped in prelim test: 954 Number of HSP's that attempted gapping in prelim test: 6201 Number of HSP's gapped (non-prelim): 4844 length of query: 1037 length of database: 18,247,518 effective HSP length: 112 effective length of query: 925 effective length of database: 14,006,526 effective search space: 12956036550 effective search space used: 12956036550 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.