Guide to the Human Genome
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Search of human proteins with 34328899

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34328899 protein tyrosine phosphatase, non-receptor type 14
[Homo sapiens]
         (1187 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [...  2404   0.0  
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ...  1222   0.0  
gi|223941891 protein tyrosine phosphatase, non-receptor type 3 i...   214   3e-55
gi|223941888 protein tyrosine phosphatase, non-receptor type 3 i...   214   3e-55
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i...   214   3e-55
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i...   214   3e-55
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...   214   3e-55
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...   214   3e-55
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...   203   9e-52
gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is...   177   7e-44
gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is...   177   7e-44
gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is...   177   7e-44
gi|109138573 protein tyrosine phosphatase, non-receptor type 20A...   175   2e-43
gi|109138561 protein tyrosine phosphatase, non-receptor type 20A...   175   2e-43
gi|109138557 protein tyrosine phosphatase, non-receptor type 20A...   175   2e-43
gi|108802617 protein tyrosine phosphatase, non-receptor type 20 ...   175   2e-43
gi|108802607 protein tyrosine phosphatase, non-receptor type 20 ...   175   2e-43
gi|108802604 protein tyrosine phosphatase, non-receptor type 20 ...   175   2e-43
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...   171   4e-42
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...   171   4e-42
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...   171   4e-42
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...   171   4e-42
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...   170   8e-42
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   170   8e-42
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...   170   8e-42
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   170   8e-42
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...   168   2e-41
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   168   2e-41
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   168   2e-41
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   168   2e-41

>gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [Homo
            sapiens]
          Length = 1187

 Score = 2404 bits (6230), Expect = 0.0
 Identities = 1187/1187 (100%), Positives = 1187/1187 (100%)

Query: 1    MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH 60
            MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH
Sbjct: 1    MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH 60

Query: 61   YFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYL 120
            YFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYL
Sbjct: 61   YFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYL 120

Query: 121  QVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLE 180
            QVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLE
Sbjct: 121  QVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLE 180

Query: 181  ELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIF 240
            ELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIF
Sbjct: 181  ELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIF 240

Query: 241  VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHK 300
            VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHK
Sbjct: 241  VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHK 300

Query: 301  FYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFH 360
            FYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFH
Sbjct: 301  FYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFH 360

Query: 361  GNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDI 420
            GNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDI
Sbjct: 361  GNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDI 420

Query: 421  MRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQP 480
            MRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQP
Sbjct: 421  MRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQP 480

Query: 481  EDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTP 540
            EDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTP
Sbjct: 481  EDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTP 540

Query: 541  ELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTR 600
            ELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTR
Sbjct: 541  ELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTR 600

Query: 601  KVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKS 660
            KVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKS
Sbjct: 601  KVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKS 660

Query: 661  LHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPES 720
            LHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPES
Sbjct: 661  LHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPES 720

Query: 721  VPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARV 780
            VPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARV
Sbjct: 721  VPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARV 780

Query: 781  LRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSI 840
            LRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSI
Sbjct: 781  LRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSI 840

Query: 841  IEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTL 900
            IEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTL
Sbjct: 841  IEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTL 900

Query: 901  KKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNT 960
            KKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNT
Sbjct: 901  KKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNT 960

Query: 961  GYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSH 1020
            GYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSH
Sbjct: 961  GYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSH 1020

Query: 1021 RYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDH 1080
            RYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDH
Sbjct: 1021 RYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDH 1080

Query: 1081 GCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYC 1140
            GCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYC
Sbjct: 1081 GCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYC 1140

Query: 1141 LEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI 1187
            LEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI
Sbjct: 1141 LEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI 1187


>gi|150418005 protein tyrosine phosphatase, non-receptor type 21 [Homo
            sapiens]
          Length = 1174

 Score = 1222 bits (3161), Expect = 0.0
 Identities = 658/1216 (54%), Positives = 870/1216 (71%), Gaps = 73/1216 (6%)

Query: 1    MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH 60
            +PFGLKL+RTRRY V SK+C V RI+LL++  +E TLSVESTGQE LEAVAQRLELRE  
Sbjct: 3    LPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVT 62

Query: 61   YFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYL 120
            YF LW+ +K  Q RWV+LEKPLKK LDK+A EP ++FGV+FYVP+VS LQQE TRYQYYL
Sbjct: 63   YFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYL 122

Query: 121  QVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLE 180
            Q+KKD+LEG + CTL+Q I+LAGLAVQADFGD++Q++SQDFL+++ LFP+    +E VLE
Sbjct: 123  QLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLE 182

Query: 181  ELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIF 240
            E TQKVA  H+ + G+   +AE++Y+ EVER+DG+G+E +P KD+ G+ + +G    GIF
Sbjct: 183  EATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIF 242

Query: 241  VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHK 300
            V+++ GR  V++RW+D+ N++HNKS   +EL NKEET  F T+D+E AKYI RL   RHK
Sbjct: 243  VKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVARHK 302

Query: 301  FYKQNKICTE-QSNSPPPIRRQPTWSRSSLPRQQPYIL-PPVHVQCGEHYSETH-TSQDS 357
            FY+ N+   + Q+ +  PIRR+ + SR SLP+ QPY++ PP  +    HY+E + +SQD+
Sbjct: 303  FYRLNQCNLQTQTVTVNPIRRRSS-SRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQDN 361

Query: 358  IFHGNEEALYCNSHNSLDLNY--LNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSI 415
            +F  N+   YC+S  SLD     LNG + NGSV S HS NSLN  Q ++Q SP+SSN SI
Sbjct: 362  LFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPSI 421

Query: 416  PGSDIMRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTH 475
             GSD+MR DY+PSHRHSA+I PSYRPTPDYETVM+Q+ RG++H + QS SLRNLNI +++
Sbjct: 422  TGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSSY 481

Query: 476  AYNQPEDLVYSQPEMRERHPYTVPYGPQGVY--SNKLVSPSDQRNPKNNVVPSKPGASAI 533
            AY++P  LVYSQPE+RE      P      +  S    SPS    P       +P   A 
Sbjct: 482  AYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAER----RPVVGA- 536

Query: 534  SHTVSTPELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGS 593
               VS PEL N QLQ + +Y + ++++  ++RPPPPYP PRPA STPDL+  RH Y+S S
Sbjct: 537  ---VSVPELTNAQLQ-AQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLS--RHLYISSS 590

Query: 594  SPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGM 653
            +PDL+TR+V  SV+TFQEDS PV H SLQEVSEPLTA + H  ++KR+S+EV   +  G+
Sbjct: 591  NPDLITRRVHHSVQTFQEDSLPVAH-SLQEVSEPLTAAR-HAQLHKRNSIEVA-GLSHGL 647

Query: 654  EAMTLKSLHL-----------------PMARRNTLREQGPPEEGSGSHEVPQLPQYHHKK 696
            E + LK   L                 P       + +G PEE  G        +Y HKK
Sbjct: 648  EGLRLKERTLSASAAEVAPRAVSVGSQPSVFTERTQREG-PEEAEGL-------RYGHKK 699

Query: 697  TFSDATMLIHSSESEEEEEEAPESVPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPR 756
            + SDATMLIHSSE EE+E+   ES  + P  R +     + +  LA+ P       PG  
Sbjct: 700  SLSDATMLIHSSEEEEDEDFEEESGARAPPARAR-----EPRPGLAQDP-------PGCP 747

Query: 757  KSVSNGALR--QDQASLPPAMARARVLRHGPAKAISMSRTDPPAVNGASLGPSISEPDL- 813
            + +  G L   + +A +P   A  R++   P +  + +    P  +G  L PS+SE DL 
Sbjct: 748  RVLLAGPLHILEPKAHVPD--AEKRMMDSSPVR--TTAEAQRPWRDGL-LMPSMSESDLT 802

Query: 814  TSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMAGLEAQK-RPLMLAALNG 872
            TS + R +++ +K+RPVS++ S + +I+E    +  ++K +   ++A+K  PL LAALNG
Sbjct: 803  TSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMKKTR---VDAKKIGPLKLAALNG 859

Query: 873  LSVARVSGREENRVDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKK-ANGIFSTAALP 931
            LS++RV   +E +  ATR   DER + L+++LE+GMVFTEYE+I KK+  +G  STA LP
Sbjct: 860  LSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTARLP 919

Query: 932  ENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEWHYIATQGPLPHTCH 991
            ENAER+R ++V+PY++ RVEL+PTKENNTGYINASHIKV V G EW YIATQGPL +TC 
Sbjct: 920  ENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQ 979

Query: 992  DFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCY 1051
            DFWQMVWEQG+ +IAMVTAEEEGGR KS RYWP+LGS+H++ TYG+FK+TT+FRTDS CY
Sbjct: 980  DFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCY 1039

Query: 1052 ATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTK 1111
            ATTGLK+KHLL+GQERTVWHLQYTDWP+HGCPED++GFLSYLEEIQSVRRHTNS  +  +
Sbjct: 1040 ATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSD-PQ 1098

Query: 1112 NRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYK 1171
            + +PP++VHCSAGVGRTGV+ILSE+MI CLEHNE +++P +L +LR+QRM ++QT+ QY 
Sbjct: 1099 SPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYT 1158

Query: 1172 FVYQVLIQFLQNSRLI 1187
            FVY+VLIQFL++SRLI
Sbjct: 1159 FVYRVLIQFLKSSRLI 1174


>gi|223941891 protein tyrosine phosphatase, non-receptor type 3
            isoform 6 [Homo sapiens]
          Length = 581

 Score =  214 bits (546), Expect = 3e-55
 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%)

Query: 900  LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959
            LKK LE G V  ++EQ+ +KK     + A LP+N +++R ++V+PY+  RV L    + N
Sbjct: 305  LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 360

Query: 960  TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
              YINAS++ + +  A     YIATQGPLPHTC  FWQ+VW+Q +++I M+T   E GRT
Sbjct: 361  EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 420

Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
            K H+YWP          +G F +  +    ++ Y +  + V +  +G+E TV HLQY  W
Sbjct: 421  KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 477

Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137
            PDHG P+D   FL ++  ++S+R  +            P++VHCSAG+GRTGVL+  E  
Sbjct: 478  PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 526

Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
            +   E N  +    ++R +R+QR  M+QT +QYKFV + +++
Sbjct: 527  MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 568


>gi|223941888 protein tyrosine phosphatase, non-receptor type 3
            isoform 5 [Homo sapiens]
          Length = 626

 Score =  214 bits (546), Expect = 3e-55
 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%)

Query: 900  LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959
            LKK LE G V  ++EQ+ +KK     + A LP+N +++R ++V+PY+  RV L    + N
Sbjct: 350  LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 405

Query: 960  TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
              YINAS++ + +  A     YIATQGPLPHTC  FWQ+VW+Q +++I M+T   E GRT
Sbjct: 406  EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 465

Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
            K H+YWP          +G F +  +    ++ Y +  + V +  +G+E TV HLQY  W
Sbjct: 466  KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 522

Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137
            PDHG P+D   FL ++  ++S+R  +            P++VHCSAG+GRTGVL+  E  
Sbjct: 523  PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 571

Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
            +   E N  +    ++R +R+QR  M+QT +QYKFV + +++
Sbjct: 572  MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 613


>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
            isoform 4 [Homo sapiens]
          Length = 737

 Score =  214 bits (546), Expect = 3e-55
 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%)

Query: 900  LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959
            LKK LE G V  ++EQ+ +KK     + A LP+N +++R ++V+PY+  RV L    + N
Sbjct: 461  LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 516

Query: 960  TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
              YINAS++ + +  A     YIATQGPLPHTC  FWQ+VW+Q +++I M+T   E GRT
Sbjct: 517  EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 576

Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
            K H+YWP          +G F +  +    ++ Y +  + V +  +G+E TV HLQY  W
Sbjct: 577  KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 633

Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137
            PDHG P+D   FL ++  ++S+R  +            P++VHCSAG+GRTGVL+  E  
Sbjct: 634  PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 682

Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
            +   E N  +    ++R +R+QR  M+QT +QYKFV + +++
Sbjct: 683  MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 724



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 70/303 (23%), Positives = 130/303 (42%), Gaps = 22/303 (7%)

Query: 125 DVLEGRLRCTLDQVIRLAGLAVQADFGDYNQ-FDSQDFLREYVLFPMDLALEEAVLEELT 183
           D+ EGRL C L+  + LA  AVQ+ FGDYN       +L +    P          E+  
Sbjct: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQN-------EDFL 54

Query: 184 QKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRN 243
            KV   H+ HSG+  +EAE  YIN    LD +G E+   +D H   + +GI   G+ V  
Sbjct: 55  TKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR 114

Query: 244 RIGRQAVIYRWNDMGNITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATR 298
           +    +  Y W ++  I+  +    +     +  ++E    F+  +  + K + +     
Sbjct: 115 KYICTS-FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEH 173

Query: 299 HKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSI 358
           H F++  K+  ++ N    + +  T    +  ++ P +     ++   H S  + + +  
Sbjct: 174 HTFFQAKKLLPQEKN---VLSQYWTMGSRNTKKRSPRLRH--EIRKPRHSSADNLANEMT 228

Query: 359 FHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFI---QASPVSSNLSI 415
           +    E ++     SL     +  V+        S++  N +QS++    +S VS + + 
Sbjct: 229 YITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNA 288

Query: 416 PGS 418
           PGS
Sbjct: 289 PGS 291


>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
            isoform 3 [Homo sapiens]
          Length = 782

 Score =  214 bits (546), Expect = 3e-55
 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%)

Query: 900  LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959
            LKK LE G V  ++EQ+ +KK     + A LP+N +++R ++V+PY+  RV L    + N
Sbjct: 506  LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 561

Query: 960  TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
              YINAS++ + +  A     YIATQGPLPHTC  FWQ+VW+Q +++I M+T   E GRT
Sbjct: 562  EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 621

Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
            K H+YWP          +G F +  +    ++ Y +  + V +  +G+E TV HLQY  W
Sbjct: 622  KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 678

Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137
            PDHG P+D   FL ++  ++S+R  +            P++VHCSAG+GRTGVL+  E  
Sbjct: 679  PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 727

Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
            +   E N  +    ++R +R+QR  M+QT +QYKFV + +++
Sbjct: 728  MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 769



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 52/195 (26%), Positives = 88/195 (45%), Gaps = 14/195 (7%)

Query: 125 DVLEGRLRCTLDQVIRLAGLAVQADFGDYNQ-FDSQDFLREYVLFPMDLALEEAVLEELT 183
           D+ EGRL C L+  + LA  AVQ+ FGDYN       +L +    P          E+  
Sbjct: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQN-------EDFL 54

Query: 184 QKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRN 243
            KV   H+ HSG+  +EAE  YIN    LD +G E+   +D H   + +GI   G+ V  
Sbjct: 55  TKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR 114

Query: 244 RIGRQAVIYRWNDMGNITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATR 298
           +    +  Y W ++  I+  +    +     +  ++E    F+  +  + K + +     
Sbjct: 115 KYICTS-FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEH 173

Query: 299 HKFYKQNKICTEQSN 313
           H F++  K+  ++ N
Sbjct: 174 HTFFQAKKLLPQEKN 188


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
            isoform 2 [Homo sapiens]
          Length = 868

 Score =  214 bits (546), Expect = 3e-55
 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%)

Query: 900  LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959
            LKK LE G V  ++EQ+ +KK     + A LP+N +++R ++V+PY+  RV L    + N
Sbjct: 592  LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 647

Query: 960  TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
              YINAS++ + +  A     YIATQGPLPHTC  FWQ+VW+Q +++I M+T   E GRT
Sbjct: 648  EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 707

Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
            K H+YWP          +G F +  +    ++ Y +  + V +  +G+E TV HLQY  W
Sbjct: 708  KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 764

Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137
            PDHG P+D   FL ++  ++S+R  +            P++VHCSAG+GRTGVL+  E  
Sbjct: 765  PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 813

Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
            +   E N  +    ++R +R+QR  M+QT +QYKFV + +++
Sbjct: 814  MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 855



 Score =  132 bits (333), Expect = 1e-30
 Identities = 108/407 (26%), Positives = 185/407 (45%), Gaps = 24/407 (5%)

Query: 22  VTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQA-RWVELEK 80
           +  I  LD  V    ++ + TGQ  L+ V   L + E  YFGL     S  + RW+E  K
Sbjct: 30  ICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASK 89

Query: 81  PLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIR 140
            ++K L K      L F V F++P+ + LQQE TR+ Y+LQ+K D+ EGRL C L+  + 
Sbjct: 90  AIRKQL-KGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVV 148

Query: 141 LAGLAVQADFGDYN-QFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPA 199
           LA  AVQ+ FGDYN       +L +    P          E+   KV   H+ HSG+  +
Sbjct: 149 LASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ-------NEDFLTKVESLHEQHSGLKQS 201

Query: 200 EAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGN 259
           EAE  YIN    LD +G E+   +D H   + +GI   G+ V  +    +  Y W ++  
Sbjct: 202 EAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS-FYPWVNILK 260

Query: 260 ITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATRHKFYKQNKICTEQSNS 314
           I+  +    +     +  ++E    F+  +  + K + +     H F++  K+  ++ N 
Sbjct: 261 ISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKN- 319

Query: 315 PPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFHGNEEALYCNSHNSL 374
              + +  T    +  ++ P +     ++   H S  + + +  +    E ++     SL
Sbjct: 320 --VLSQYWTMGSRNTKKRSPRLRH--EIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 375

Query: 375 DLNYLNGTVTNGSVCSVHSVNSLNCSQSFI---QASPVSSNLSIPGS 418
                +  V+        S++  N +QS++    +S VS + + PGS
Sbjct: 376 APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS 422


>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
            isoform 1 [Homo sapiens]
          Length = 913

 Score =  214 bits (546), Expect = 3e-55
 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%)

Query: 900  LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959
            LKK LE G V  ++EQ+ +KK     + A LP+N +++R ++V+PY+  RV L    + N
Sbjct: 637  LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 692

Query: 960  TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
              YINAS++ + +  A     YIATQGPLPHTC  FWQ+VW+Q +++I M+T   E GRT
Sbjct: 693  EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 752

Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
            K H+YWP          +G F +  +    ++ Y +  + V +  +G+E TV HLQY  W
Sbjct: 753  KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 809

Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137
            PDHG P+D   FL ++  ++S+R  +            P++VHCSAG+GRTGVL+  E  
Sbjct: 810  PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 858

Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
            +   E N  +    ++R +R+QR  M+QT +QYKFV + +++
Sbjct: 859  MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 900



 Score =  129 bits (323), Expect = 2e-29
 Identities = 90/299 (30%), Positives = 143/299 (47%), Gaps = 16/299 (5%)

Query: 22  VTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQA-RWVELEK 80
           +  I  LD  V    ++ + TGQ  L+ V   L + E  YFGL     S  + RW+E  K
Sbjct: 30  ICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASK 89

Query: 81  PLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIR 140
            ++K L K      L F V F++P+ + LQQE TR+ Y+LQ+K D+ EGRL C L+  + 
Sbjct: 90  AIRKQL-KGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVV 148

Query: 141 LAGLAVQADFGDYN-QFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPA 199
           LA  AVQ+ FGDYN       +L +    P          E+   KV   H+ HSG+  +
Sbjct: 149 LASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ-------NEDFLTKVESLHEQHSGLKQS 201

Query: 200 EAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGN 259
           EAE  YIN    LD +G E+   +D H   + +GI   G+ V  +    +  Y W ++  
Sbjct: 202 EAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS-FYPWVNILK 260

Query: 260 ITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATRHKFYKQNKICTEQSN 313
           I+  +    +     +  ++E    F+  +  + K + +     H F++  K+  ++ N
Sbjct: 261 ISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKN 319


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
            sapiens]
          Length = 926

 Score =  203 bits (516), Expect = 9e-52
 Identities = 106/282 (37%), Positives = 164/282 (58%), Gaps = 19/282 (6%)

Query: 900  LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959
            L + L  G V T+++Q+ +KK     S A LP+N  ++R R++ PY+  RV L    + N
Sbjct: 646  LAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVIL----KGN 701

Query: 960  TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
              YINA++I + +  +     YIA QGPLPHTC DFWQM WEQG +++ M+T + E GR 
Sbjct: 702  EDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRV 761

Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
            K H+YWP+      S++YG ++VT      +  Y    + + +    + R +  +QY  W
Sbjct: 762  KCHQYWPE---PTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAW 818

Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137
            PDHG P+D   FL ++  +++ R            +  P+VVHCSAG+GRTGVLI  E  
Sbjct: 819  PDHGVPDDSSDFLDFVCHVRNKR----------AGKEEPVVVHCSAGIGRTGVLITMETA 868

Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
            +  +E N+ V    ++R +R+QR  MIQT +QY+FV + +++
Sbjct: 869  MCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK 910



 Score =  136 bits (343), Expect = 1e-31
 Identities = 93/300 (31%), Positives = 150/300 (50%), Gaps = 18/300 (6%)

Query: 22  VTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKS-QQARWVELEK 80
           V  I LLD+ V    ++    GQ  L+ V + L+L E  YFGL     S    RW++  K
Sbjct: 30  VCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNK 89

Query: 81  PLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIR 140
           P++K L K  +   L F V F+V + + LQ+E TRYQY+LQ+K+D+L GRL C  +    
Sbjct: 90  PIRKQL-KRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAAL 148

Query: 141 LAGLAVQADFGDYNQFDS-QDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPA 199
           LA  AVQ++ GDY+Q ++   +L +Y   P          ++  +++A+ H+ H G+ PA
Sbjct: 149 LASFAVQSELGDYDQSENLSGYLSDYSFIPNQ-------PQDFEKEIAKLHQQHIGLSPA 201

Query: 200 EAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFV-RNRIGRQAVIYRWNDMG 258
           EAE  Y+N    L+ +G E    +D   N + +G+   GI + +NR+      + W  + 
Sbjct: 202 EAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNT--FPWLKIV 259

Query: 259 NITHNKSTILV----ELINKEETAL-FHTDDIENAKYISRLFATRHKFYKQNKICTEQSN 313
            I+       +    EL    ET L F+  +    K + +     H F++ ++    Q N
Sbjct: 260 KISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKN 319


>gi|18104993 protein tyrosine phosphatase, non-receptor type 6 isoform
            3 [Homo sapiens]
          Length = 624

 Score =  177 bits (448), Expect = 7e-44
 Identities = 110/317 (34%), Positives = 173/317 (54%), Gaps = 30/317 (9%)

Query: 888  ATRV---PMDERFRTLKKKLE-----EGMVFTEYEQIPKKKANGIFST--AALPENAERS 937
            ATRV    ++ R   L KK E     +   + E+E + K++   +        PEN  ++
Sbjct: 215  ATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKN 274

Query: 938  RIREVVPYEENRVELIPTKENNTG--YINASHIKVVVGGAEWH---YIATQGPLPHTCHD 992
            R + ++P++ +RV L     N  G  YINA++IK  + G + +   YIA+QG L  T +D
Sbjct: 275  RYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVND 334

Query: 993  FWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYA 1052
            FWQM W++   VI M T E E GR K   YWP++G + +   YG + VT     D+  Y 
Sbjct: 335  FWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRA---YGPYSVTNCGEHDTTEYK 391

Query: 1053 TTGLKVKHLLSGQ-ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTK 1111
               L+V  L +G   R +WH QY  WPDHG P +  G LS+L++I       N   E   
Sbjct: 392  LRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-------NQRQESLP 444

Query: 1112 NRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNE---KVEVPMMLRLLREQRMFMIQTIA 1168
            +   PI+VHCSAG+GRTG +I+ ++++  +        +++   ++++R QR  M+QT A
Sbjct: 445  HA-GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEA 503

Query: 1169 QYKFVYQVLIQFLQNSR 1185
            QYKF+Y  + QF++ ++
Sbjct: 504  QYKFIYVAIAQFIETTK 520


>gi|18104989 protein tyrosine phosphatase, non-receptor type 6 isoform
            1 [Homo sapiens]
          Length = 595

 Score =  177 bits (448), Expect = 7e-44
 Identities = 110/317 (34%), Positives = 173/317 (54%), Gaps = 30/317 (9%)

Query: 888  ATRV---PMDERFRTLKKKLE-----EGMVFTEYEQIPKKKANGIFST--AALPENAERS 937
            ATRV    ++ R   L KK E     +   + E+E + K++   +        PEN  ++
Sbjct: 215  ATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKN 274

Query: 938  RIREVVPYEENRVELIPTKENNTG--YINASHIKVVVGGAEWH---YIATQGPLPHTCHD 992
            R + ++P++ +RV L     N  G  YINA++IK  + G + +   YIA+QG L  T +D
Sbjct: 275  RYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVND 334

Query: 993  FWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYA 1052
            FWQM W++   VI M T E E GR K   YWP++G + +   YG + VT     D+  Y 
Sbjct: 335  FWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRA---YGPYSVTNCGEHDTTEYK 391

Query: 1053 TTGLKVKHLLSGQ-ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTK 1111
               L+V  L +G   R +WH QY  WPDHG P +  G LS+L++I       N   E   
Sbjct: 392  LRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-------NQRQESLP 444

Query: 1112 NRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNE---KVEVPMMLRLLREQRMFMIQTIA 1168
            +   PI+VHCSAG+GRTG +I+ ++++  +        +++   ++++R QR  M+QT A
Sbjct: 445  HA-GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEA 503

Query: 1169 QYKFVYQVLIQFLQNSR 1185
            QYKF+Y  + QF++ ++
Sbjct: 504  QYKFIYVAIAQFIETTK 520


>gi|18104991 protein tyrosine phosphatase, non-receptor type 6 isoform
            2 [Homo sapiens]
          Length = 597

 Score =  177 bits (448), Expect = 7e-44
 Identities = 110/317 (34%), Positives = 173/317 (54%), Gaps = 30/317 (9%)

Query: 888  ATRV---PMDERFRTLKKKLE-----EGMVFTEYEQIPKKKANGIFST--AALPENAERS 937
            ATRV    ++ R   L KK E     +   + E+E + K++   +        PEN  ++
Sbjct: 217  ATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKN 276

Query: 938  RIREVVPYEENRVELIPTKENNTG--YINASHIKVVVGGAEWH---YIATQGPLPHTCHD 992
            R + ++P++ +RV L     N  G  YINA++IK  + G + +   YIA+QG L  T +D
Sbjct: 277  RYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVND 336

Query: 993  FWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYA 1052
            FWQM W++   VI M T E E GR K   YWP++G + +   YG + VT     D+  Y 
Sbjct: 337  FWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRA---YGPYSVTNCGEHDTTEYK 393

Query: 1053 TTGLKVKHLLSGQ-ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTK 1111
               L+V  L +G   R +WH QY  WPDHG P +  G LS+L++I       N   E   
Sbjct: 394  LRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-------NQRQESLP 446

Query: 1112 NRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNE---KVEVPMMLRLLREQRMFMIQTIA 1168
            +   PI+VHCSAG+GRTG +I+ ++++  +        +++   ++++R QR  M+QT A
Sbjct: 447  HA-GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEA 505

Query: 1169 QYKFVYQVLIQFLQNSR 1185
            QYKF+Y  + QF++ ++
Sbjct: 506  QYKFIYVAIAQFIETTK 522


>gi|109138573 protein tyrosine phosphatase, non-receptor type 20A
            isoform 8 [Homo sapiens]
          Length = 339

 Score =  175 bits (444), Expect = 2e-43
 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%)

Query: 898  RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957
            + L++K     +  E+  +  K   G F++   P N E++R R+++PY+  RV L  +K+
Sbjct: 67   KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 126

Query: 958  NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
                YINAS+I++V  G E+ YIATQGPL  T  DFWQMV E   NVIAM+T E EGG  
Sbjct: 127  ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 182

Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072
            K + YWP      L  KH       +++   F            +V    +G   +V  L
Sbjct: 183  KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 235

Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132
            Q+T WPDHG P     F+ Y      +R    S L G      P+VVHCSAG+GRTGV +
Sbjct: 236  QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 283

Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182
              +++   +  N    +  ++  +REQR  M+QT  QY F Y ++++ L+
Sbjct: 284  CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 333


>gi|109138561 protein tyrosine phosphatase, non-receptor type 20A
            isoform 3 [Homo sapiens]
          Length = 411

 Score =  175 bits (444), Expect = 2e-43
 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%)

Query: 898  RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957
            + L++K     +  E+  +  K   G F++   P N E++R R+++PY+  RV L  +K+
Sbjct: 139  KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 198

Query: 958  NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
                YINAS+I++V  G E+ YIATQGPL  T  DFWQMV E   NVIAM+T E EGG  
Sbjct: 199  ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 254

Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072
            K + YWP      L  KH       +++   F            +V    +G   +V  L
Sbjct: 255  KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 307

Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132
            Q+T WPDHG P     F+ Y      +R    S L G      P+VVHCSAG+GRTGV +
Sbjct: 308  QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 355

Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182
              +++   +  N    +  ++  +REQR  M+QT  QY F Y ++++ L+
Sbjct: 356  CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 405


>gi|109138557 protein tyrosine phosphatase, non-receptor type 20A
            isoform 1 [Homo sapiens]
          Length = 420

 Score =  175 bits (444), Expect = 2e-43
 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%)

Query: 898  RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957
            + L++K     +  E+  +  K   G F++   P N E++R R+++PY+  RV L  +K+
Sbjct: 148  KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 207

Query: 958  NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
                YINAS+I++V  G E+ YIATQGPL  T  DFWQMV E   NVIAM+T E EGG  
Sbjct: 208  ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 263

Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072
            K + YWP      L  KH       +++   F            +V    +G   +V  L
Sbjct: 264  KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 316

Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132
            Q+T WPDHG P     F+ Y      +R    S L G      P+VVHCSAG+GRTGV +
Sbjct: 317  QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 364

Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182
              +++   +  N    +  ++  +REQR  M+QT  QY F Y ++++ L+
Sbjct: 365  CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 414


>gi|108802617 protein tyrosine phosphatase, non-receptor type 20
            isoform 8 [Homo sapiens]
          Length = 339

 Score =  175 bits (444), Expect = 2e-43
 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%)

Query: 898  RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957
            + L++K     +  E+  +  K   G F++   P N E++R R+++PY+  RV L  +K+
Sbjct: 67   KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 126

Query: 958  NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
                YINAS+I++V  G E+ YIATQGPL  T  DFWQMV E   NVIAM+T E EGG  
Sbjct: 127  ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 182

Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072
            K + YWP      L  KH       +++   F            +V    +G   +V  L
Sbjct: 183  KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 235

Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132
            Q+T WPDHG P     F+ Y      +R    S L G      P+VVHCSAG+GRTGV +
Sbjct: 236  QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 283

Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182
              +++   +  N    +  ++  +REQR  M+QT  QY F Y ++++ L+
Sbjct: 284  CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 333


>gi|108802607 protein tyrosine phosphatase, non-receptor type 20
            isoform 3 [Homo sapiens]
          Length = 411

 Score =  175 bits (444), Expect = 2e-43
 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%)

Query: 898  RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957
            + L++K     +  E+  +  K   G F++   P N E++R R+++PY+  RV L  +K+
Sbjct: 139  KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 198

Query: 958  NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
                YINAS+I++V  G E+ YIATQGPL  T  DFWQMV E   NVIAM+T E EGG  
Sbjct: 199  ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 254

Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072
            K + YWP      L  KH       +++   F            +V    +G   +V  L
Sbjct: 255  KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 307

Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132
            Q+T WPDHG P     F+ Y      +R    S L G      P+VVHCSAG+GRTGV +
Sbjct: 308  QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 355

Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182
              +++   +  N    +  ++  +REQR  M+QT  QY F Y ++++ L+
Sbjct: 356  CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 405


>gi|108802604 protein tyrosine phosphatase, non-receptor type 20
            isoform 1 [Homo sapiens]
          Length = 420

 Score =  175 bits (444), Expect = 2e-43
 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%)

Query: 898  RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957
            + L++K     +  E+  +  K   G F++   P N E++R R+++PY+  RV L  +K+
Sbjct: 148  KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 207

Query: 958  NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
                YINAS+I++V  G E+ YIATQGPL  T  DFWQMV E   NVIAM+T E EGG  
Sbjct: 208  ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 263

Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072
            K + YWP      L  KH       +++   F            +V    +G   +V  L
Sbjct: 264  KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 316

Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132
            Q+T WPDHG P     F+ Y      +R    S L G      P+VVHCSAG+GRTGV +
Sbjct: 317  QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 364

Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182
              +++   +  N    +  ++  +REQR  M+QT  QY F Y ++++ L+
Sbjct: 365  CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 414


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score =  171 bits (433), Expect = 4e-42
 Identities = 98/287 (34%), Positives = 153/287 (53%), Gaps = 23/287 (8%)

Query: 898  RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957
            R L+  L++G+   E E + + K           EN  ++R + ++PY+  RV L     
Sbjct: 2207 RVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPL----G 2262

Query: 958  NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
            +  GYINAS IK+ VG  E+ YIA QGPLP T  DFWQM+WEQ   VIAM+T E EG + 
Sbjct: 2263 DEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKI 2322

Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
            K  RYWP +  K ++    + ++          +    + ++ + + + R + HL +T W
Sbjct: 2323 KCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAW 2381

Query: 1078 PDHGC---PEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILS 1134
            PDH     P+D+  F+SY+  I               +R  PI+ HCSAG+GR+G LI  
Sbjct: 2382 PDHDTPSQPDDLLTFISYMRHI---------------HRSGPIITHCSAGIGRSGTLICI 2426

Query: 1135 ELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181
            ++++  +  +   ++  ++R +R QR  M+QT  QY F YQV++  L
Sbjct: 2427 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2473



 Score =  100 bits (249), Expect = 8e-21
 Identities = 86/314 (27%), Positives = 142/314 (45%), Gaps = 37/314 (11%)

Query: 25  IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGL-------WF-------LSKS 70
           I LL+   +E T   ++  ++  + V   + L E H F L       +F       L+K 
Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKV 635

Query: 71  QQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGR 130
               W E  K   K    F     LFF + F++ +VS +Q   T +QYYLQ++KD+LE R
Sbjct: 636 APEGWKEEPKKKTKATVNFT----LFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEER 691

Query: 131 LRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQE- 189
           + C  +  + LA LA+QA++GDY     Q  +     F M+  L   V+E+L     +E 
Sbjct: 692 MHCDDETSLLLASLALQAEYGDY-----QPEVHGVSYFRMEHYLPARVMEKLDLSYIKEE 746

Query: 190 ----HKAHSGILPAEAELMYINEVERLDGFG---QEIFPVKDNHGNCVHLGIFFMGIF-- 240
               H  + G    E EL ++   +RL  +G     + P K +    + LG+   G+   
Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTG-ILLGVCSKGVLVF 805

Query: 241 -VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRH 299
            V N +    + + W +   I+ +K  I ++  +      F TD+ +  +Y+  L + +H
Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQH 865

Query: 300 KFYKQNKICTEQSN 313
           KF  Q +    QSN
Sbjct: 866 KFQLQMR--ARQSN 877


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score =  171 bits (433), Expect = 4e-42
 Identities = 98/287 (34%), Positives = 153/287 (53%), Gaps = 23/287 (8%)

Query: 898  RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957
            R L+  L++G+   E E + + K           EN  ++R + ++PY+  RV L     
Sbjct: 2011 RVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPL----G 2066

Query: 958  NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
            +  GYINAS IK+ VG  E+ YIA QGPLP T  DFWQM+WEQ   VIAM+T E EG + 
Sbjct: 2067 DEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKI 2126

Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
            K  RYWP +  K ++    + ++          +    + ++ + + + R + HL +T W
Sbjct: 2127 KCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAW 2185

Query: 1078 PDHGC---PEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILS 1134
            PDH     P+D+  F+SY+  I               +R  PI+ HCSAG+GR+G LI  
Sbjct: 2186 PDHDTPSQPDDLLTFISYMRHI---------------HRSGPIITHCSAGIGRSGTLICI 2230

Query: 1135 ELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181
            ++++  +  +   ++  ++R +R QR  M+QT  QY F YQV++  L
Sbjct: 2231 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2277



 Score =  101 bits (251), Expect = 5e-21
 Identities = 87/334 (26%), Positives = 147/334 (44%), Gaps = 35/334 (10%)

Query: 25  IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGL-------WF-------LSKS 70
           I LL+   +E T   ++  ++  + V   + L E H F L       +F       L+K 
Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKV 635

Query: 71  QQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGR 130
               W E  K   K    F     LFF + F++ +VS +Q   T +QYYLQ++KD+LE R
Sbjct: 636 APEGWKEEPKKKTKATVNFT----LFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEER 691

Query: 131 LRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQE- 189
           + C  +  + LA LA+QA++GDY     Q  +     F M+  L   V+E+L     +E 
Sbjct: 692 MHCDDETSLLLASLALQAEYGDY-----QPEVHGVSYFRMEHYLPARVMEKLDLSYIKEE 746

Query: 190 ----HKAHSGILPAEAELMYINEVERLDGFG---QEIFPVKDNHGNCVHLGIFFMGIF-- 240
               H  + G    E EL ++   +RL  +G     + P K +    + LG+   G+   
Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTG-ILLGVCSKGVLVF 805

Query: 241 -VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRH 299
            V N +    + + W +   I+ +K  I ++  +      F TD+ +  +Y+  L + +H
Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQH 865

Query: 300 KFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQ 333
           KF  Q +      ++         WS  S P ++
Sbjct: 866 KFQLQMRARQSNQDAQDIDVLHKRWSIVSSPERE 899


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score =  171 bits (433), Expect = 4e-42
 Identities = 98/287 (34%), Positives = 153/287 (53%), Gaps = 23/287 (8%)

Query: 898  RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957
            R L+  L++G+   E E + + K           EN  ++R + ++PY+  RV L     
Sbjct: 2202 RVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPL----G 2257

Query: 958  NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
            +  GYINAS IK+ VG  E+ YIA QGPLP T  DFWQM+WEQ   VIAM+T E EG + 
Sbjct: 2258 DEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKI 2317

Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
            K  RYWP +  K ++    + ++          +    + ++ + + + R + HL +T W
Sbjct: 2318 KCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAW 2376

Query: 1078 PDHGC---PEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILS 1134
            PDH     P+D+  F+SY+  I               +R  PI+ HCSAG+GR+G LI  
Sbjct: 2377 PDHDTPSQPDDLLTFISYMRHI---------------HRSGPIITHCSAGIGRSGTLICI 2421

Query: 1135 ELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181
            ++++  +  +   ++  ++R +R QR  M+QT  QY F YQV++  L
Sbjct: 2422 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2468



 Score =  100 bits (249), Expect = 8e-21
 Identities = 86/314 (27%), Positives = 142/314 (45%), Gaps = 37/314 (11%)

Query: 25  IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGL-------WF-------LSKS 70
           I LL+   +E T   ++  ++  + V   + L E H F L       +F       L+K 
Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKV 635

Query: 71  QQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGR 130
               W E  K   K    F     LFF + F++ +VS +Q   T +QYYLQ++KD+LE R
Sbjct: 636 APEGWKEEPKKKTKATVNFT----LFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEER 691

Query: 131 LRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQE- 189
           + C  +  + LA LA+QA++GDY     Q  +     F M+  L   V+E+L     +E 
Sbjct: 692 MHCDDETSLLLASLALQAEYGDY-----QPEVHGVSYFRMEHYLPARVMEKLDLSYIKEE 746

Query: 190 ----HKAHSGILPAEAELMYINEVERLDGFG---QEIFPVKDNHGNCVHLGIFFMGIF-- 240
               H  + G    E EL ++   +RL  +G     + P K +    + LG+   G+   
Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTG-ILLGVCSKGVLVF 805

Query: 241 -VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRH 299
            V N +    + + W +   I+ +K  I ++  +      F TD+ +  +Y+  L + +H
Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQH 865

Query: 300 KFYKQNKICTEQSN 313
           KF  Q +    QSN
Sbjct: 866 KFQLQMR--ARQSN 877


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score =  171 bits (433), Expect = 4e-42
 Identities = 98/287 (34%), Positives = 153/287 (53%), Gaps = 23/287 (8%)

Query: 898  RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957
            R L+  L++G+   E E + + K           EN  ++R + ++PY+  RV L     
Sbjct: 2183 RVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPL----G 2238

Query: 958  NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
            +  GYINAS IK+ VG  E+ YIA QGPLP T  DFWQM+WEQ   VIAM+T E EG + 
Sbjct: 2239 DEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKI 2298

Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
            K  RYWP +  K ++    + ++          +    + ++ + + + R + HL +T W
Sbjct: 2299 KCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAW 2357

Query: 1078 PDHGC---PEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILS 1134
            PDH     P+D+  F+SY+  I               +R  PI+ HCSAG+GR+G LI  
Sbjct: 2358 PDHDTPSQPDDLLTFISYMRHI---------------HRSGPIITHCSAGIGRSGTLICI 2402

Query: 1135 ELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181
            ++++  +  +   ++  ++R +R QR  M+QT  QY F YQV++  L
Sbjct: 2403 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2449



 Score =  100 bits (249), Expect = 8e-21
 Identities = 86/314 (27%), Positives = 142/314 (45%), Gaps = 37/314 (11%)

Query: 25  IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGL-------WF-------LSKS 70
           I LL+   +E T   ++  ++  + V   + L E H F L       +F       L+K 
Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKV 635

Query: 71  QQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGR 130
               W E  K   K    F     LFF + F++ +VS +Q   T +QYYLQ++KD+LE R
Sbjct: 636 APEGWKEEPKKKTKATVNFT----LFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEER 691

Query: 131 LRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQE- 189
           + C  +  + LA LA+QA++GDY     Q  +     F M+  L   V+E+L     +E 
Sbjct: 692 MHCDDETSLLLASLALQAEYGDY-----QPEVHGVSYFRMEHYLPARVMEKLDLSYIKEE 746

Query: 190 ----HKAHSGILPAEAELMYINEVERLDGFG---QEIFPVKDNHGNCVHLGIFFMGIF-- 240
               H  + G    E EL ++   +RL  +G     + P K +    + LG+   G+   
Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTG-ILLGVCSKGVLVF 805

Query: 241 -VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRH 299
            V N +    + + W +   I+ +K  I ++  +      F TD+ +  +Y+  L + +H
Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQH 865

Query: 300 KFYKQNKICTEQSN 313
           KF  Q +    QSN
Sbjct: 866 KFQLQMR--ARQSN 877


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score =  170 bits (430), Expect = 8e-42
 Identities = 113/356 (31%), Positives = 177/356 (49%), Gaps = 22/356 (6%)

Query: 834  FSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPM 893
            F + D+++ER    + ++      L   +R  M+   +  S    +  E      T VP 
Sbjct: 1156 FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPA 1215

Query: 894  DERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIREVVPYE 946
               +  ++K  ++E G   T    E++++   KA+   F +A LP N  ++R+  ++PYE
Sbjct: 1216 RSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE 1275

Query: 947  ENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVI 1005
              RV L P +    + YINAS I       +  YIATQGPL  T  DFW+M+WE    ++
Sbjct: 1276 STRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1333

Query: 1006 AMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQ 1065
             M+T   E GR K H+YWP       SA Y  F V      +   Y     KV     GQ
Sbjct: 1334 VMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1389

Query: 1066 ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGV 1125
             RTV   Q+TDWP+ G P+  +GF+ ++ ++   +            +  PI VHCSAGV
Sbjct: 1390 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVHCSAGV 1441

Query: 1126 GRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181
            GRTGV I   +++  + +   V++   +++LR QR  M+QT  +Y+F YQ  +++L
Sbjct: 1442 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1497



 Score =  153 bits (387), Expect = 8e-37
 Identities = 91/251 (36%), Positives = 135/251 (53%), Gaps = 17/251 (6%)

Query: 930  LPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPH 988
            L  N  ++R   V+ Y+ +RV L P +    + YINA+++       +  YIATQGPLP 
Sbjct: 970  LEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGY--RCQNAYIATQGPLPE 1027

Query: 989  TCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDS 1048
            T  DFW+MVWEQ    I M+T  EE  R K  +YWP  G++    TYG  +VT     + 
Sbjct: 1028 TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE----TYGFIQVTLLDTIEL 1083

Query: 1049 VCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLE 1108
              +      +    S ++R V   Q+T WPDHG PE    FL++L  +++          
Sbjct: 1084 ATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG--- 1140

Query: 1109 GTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIA 1168
                   PIVVHCSAGVGRTG  I+ + M+  ++  + V+V   + L+R QR +M+QT  
Sbjct: 1141 -------PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1193

Query: 1169 QYKFVYQVLIQ 1179
            QY F+++ L++
Sbjct: 1194 QYSFIHEALLE 1204


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  170 bits (430), Expect = 8e-42
 Identities = 113/356 (31%), Positives = 177/356 (49%), Gaps = 22/356 (6%)

Query: 834  FSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPM 893
            F + D+++ER    + ++      L   +R  M+   +  S    +  E      T VP 
Sbjct: 1561 FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPA 1620

Query: 894  DERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIREVVPYE 946
               +  ++K  ++E G   T    E++++   KA+   F +A LP N  ++R+  ++PYE
Sbjct: 1621 RSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE 1680

Query: 947  ENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVI 1005
              RV L P +    + YINAS I       +  YIATQGPL  T  DFW+M+WE    ++
Sbjct: 1681 STRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1738

Query: 1006 AMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQ 1065
             M+T   E GR K H+YWP       SA Y  F V      +   Y     KV     GQ
Sbjct: 1739 VMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1794

Query: 1066 ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGV 1125
             RTV   Q+TDWP+ G P+  +GF+ ++ ++   +            +  PI VHCSAGV
Sbjct: 1795 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVHCSAGV 1846

Query: 1126 GRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181
            GRTGV I   +++  + +   V++   +++LR QR  M+QT  +Y+F YQ  +++L
Sbjct: 1847 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1902



 Score =  153 bits (387), Expect = 8e-37
 Identities = 91/251 (36%), Positives = 135/251 (53%), Gaps = 17/251 (6%)

Query: 930  LPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPH 988
            L  N  ++R   V+ Y+ +RV L P +    + YINA+++       +  YIATQGPLP 
Sbjct: 1375 LEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGY--RCQNAYIATQGPLPE 1432

Query: 989  TCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDS 1048
            T  DFW+MVWEQ    I M+T  EE  R K  +YWP  G++    TYG  +VT     + 
Sbjct: 1433 TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE----TYGFIQVTLLDTIEL 1488

Query: 1049 VCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLE 1108
              +      +    S ++R V   Q+T WPDHG PE    FL++L  +++          
Sbjct: 1489 ATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG--- 1545

Query: 1109 GTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIA 1168
                   PIVVHCSAGVGRTG  I+ + M+  ++  + V+V   + L+R QR +M+QT  
Sbjct: 1546 -------PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1598

Query: 1169 QYKFVYQVLIQ 1179
            QY F+++ L++
Sbjct: 1599 QYSFIHEALLE 1609


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score =  170 bits (430), Expect = 8e-42
 Identities = 113/356 (31%), Positives = 177/356 (49%), Gaps = 22/356 (6%)

Query: 834  FSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPM 893
            F + D+++ER    + ++      L   +R  M+   +  S    +  E      T VP 
Sbjct: 1152 FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPA 1211

Query: 894  DERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIREVVPYE 946
               +  ++K  ++E G   T    E++++   KA+   F +A LP N  ++R+  ++PYE
Sbjct: 1212 RSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE 1271

Query: 947  ENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVI 1005
              RV L P +    + YINAS I       +  YIATQGPL  T  DFW+M+WE    ++
Sbjct: 1272 STRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1329

Query: 1006 AMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQ 1065
             M+T   E GR K H+YWP       SA Y  F V      +   Y     KV     GQ
Sbjct: 1330 VMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1385

Query: 1066 ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGV 1125
             RTV   Q+TDWP+ G P+  +GF+ ++ ++   +            +  PI VHCSAGV
Sbjct: 1386 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVHCSAGV 1437

Query: 1126 GRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181
            GRTGV I   +++  + +   V++   +++LR QR  M+QT  +Y+F YQ  +++L
Sbjct: 1438 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1493



 Score =  153 bits (387), Expect = 8e-37
 Identities = 91/251 (36%), Positives = 135/251 (53%), Gaps = 17/251 (6%)

Query: 930  LPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPH 988
            L  N  ++R   V+ Y+ +RV L P +    + YINA+++       +  YIATQGPLP 
Sbjct: 966  LEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGY--RCQNAYIATQGPLPE 1023

Query: 989  TCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDS 1048
            T  DFW+MVWEQ    I M+T  EE  R K  +YWP  G++    TYG  +VT     + 
Sbjct: 1024 TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE----TYGFIQVTLLDTIEL 1079

Query: 1049 VCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLE 1108
              +      +    S ++R V   Q+T WPDHG PE    FL++L  +++          
Sbjct: 1080 ATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG--- 1136

Query: 1109 GTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIA 1168
                   PIVVHCSAGVGRTG  I+ + M+  ++  + V+V   + L+R QR +M+QT  
Sbjct: 1137 -------PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1189

Query: 1169 QYKFVYQVLIQ 1179
            QY F+++ L++
Sbjct: 1190 QYSFIHEALLE 1200


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  170 bits (430), Expect = 8e-42
 Identities = 113/356 (31%), Positives = 177/356 (49%), Gaps = 22/356 (6%)

Query: 834  FSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPM 893
            F + D+++ER    + ++      L   +R  M+   +  S    +  E      T VP 
Sbjct: 1599 FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPA 1658

Query: 894  DERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIREVVPYE 946
               +  ++K  ++E G   T    E++++   KA+   F +A LP N  ++R+  ++PYE
Sbjct: 1659 RSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE 1718

Query: 947  ENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVI 1005
              RV L P +    + YINAS I       +  YIATQGPL  T  DFW+M+WE    ++
Sbjct: 1719 STRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1776

Query: 1006 AMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQ 1065
             M+T   E GR K H+YWP       SA Y  F V      +   Y     KV     GQ
Sbjct: 1777 VMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1832

Query: 1066 ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGV 1125
             RTV   Q+TDWP+ G P+  +GF+ ++ ++   +            +  PI VHCSAGV
Sbjct: 1833 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVHCSAGV 1884

Query: 1126 GRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181
            GRTGV I   +++  + +   V++   +++LR QR  M+QT  +Y+F YQ  +++L
Sbjct: 1885 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1940



 Score =  153 bits (387), Expect = 8e-37
 Identities = 91/251 (36%), Positives = 135/251 (53%), Gaps = 17/251 (6%)

Query: 930  LPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPH 988
            L  N  ++R   V+ Y+ +RV L P +    + YINA+++       +  YIATQGPLP 
Sbjct: 1413 LEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGY--RCQNAYIATQGPLPE 1470

Query: 989  TCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDS 1048
            T  DFW+MVWEQ    I M+T  EE  R K  +YWP  G++    TYG  +VT     + 
Sbjct: 1471 TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE----TYGFIQVTLLDTIEL 1526

Query: 1049 VCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLE 1108
              +      +    S ++R V   Q+T WPDHG PE    FL++L  +++          
Sbjct: 1527 ATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG--- 1583

Query: 1109 GTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIA 1168
                   PIVVHCSAGVGRTG  I+ + M+  ++  + V+V   + L+R QR +M+QT  
Sbjct: 1584 -------PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1636

Query: 1169 QYKFVYQVLIQ 1179
            QY F+++ L++
Sbjct: 1637 QYSFIHEALLE 1647


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score =  168 bits (426), Expect = 2e-41
 Identities = 104/301 (34%), Positives = 157/301 (52%), Gaps = 22/301 (7%)

Query: 889  TRVPMDERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIRE 941
            T VP    +  ++K  ++E G   T    E++++   KA+   F +A LP N  ++R+  
Sbjct: 1208 TEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVN 1267

Query: 942  VVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQ 1000
            ++PYE  RV L P +    + YINAS I       +  YIATQGPL  T  DFW+M+WE 
Sbjct: 1268 IMPYESTRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEH 1325

Query: 1001 GVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKH 1060
               ++ M+T   E GR K H+YWP       SA Y  F V      +   Y     KV  
Sbjct: 1326 NSTIVVMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTD 1381

Query: 1061 LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVH 1120
               GQ RTV   Q+TDWP+ G P+  +GF+ ++ ++   +            +  PI VH
Sbjct: 1382 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVH 1433

Query: 1121 CSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF 1180
            CSAGVGRTGV I   +++  + +   V++   +++LR QR  M+QT  QY+F Y+  +++
Sbjct: 1434 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1493

Query: 1181 L 1181
            L
Sbjct: 1494 L 1494



 Score =  148 bits (373), Expect = 3e-35
 Identities = 94/280 (33%), Positives = 146/280 (52%), Gaps = 21/280 (7%)

Query: 903  KLEEGMVFT-EYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTG 961
            K  + + F+ EYE I   +    +  + L  N  ++R   V+ Y+ +RV L+   E   G
Sbjct: 940  KANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPG 997

Query: 962  --YINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKS 1019
              Y+NA++I       +  YIATQG LP T  DFW+M+WEQ    + M+T  EE  R K 
Sbjct: 998  SDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKC 1055

Query: 1020 HRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPD 1079
             +YWP  G++    T+G  +VT     +   Y      +    S ++R V   Q+T WPD
Sbjct: 1056 DQYWPSRGTE----THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPD 1111

Query: 1080 HGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIY 1139
            HG PE    FL++L  +++                 P+VVHCSAGVGRTG  I+ + M+ 
Sbjct: 1112 HGVPEHPTPFLAFLRRVKTCNPPDAG----------PMVVHCSAGVGRTGCFIVIDAMLE 1161

Query: 1140 CLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
             ++H + V++   + L+R QR +M+QT  QY F++  L++
Sbjct: 1162 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE 1201


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  168 bits (426), Expect = 2e-41
 Identities = 104/301 (34%), Positives = 157/301 (52%), Gaps = 22/301 (7%)

Query: 889  TRVPMDERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIRE 941
            T VP    +  ++K  ++E G   T    E++++   KA+   F +A LP N  ++R+  
Sbjct: 1618 TEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVN 1677

Query: 942  VVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQ 1000
            ++PYE  RV L P +    + YINAS I       +  YIATQGPL  T  DFW+M+WE 
Sbjct: 1678 IMPYESTRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEH 1735

Query: 1001 GVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKH 1060
               ++ M+T   E GR K H+YWP       SA Y  F V      +   Y     KV  
Sbjct: 1736 NSTIVVMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTD 1791

Query: 1061 LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVH 1120
               GQ RTV   Q+TDWP+ G P+  +GF+ ++ ++   +            +  PI VH
Sbjct: 1792 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVH 1843

Query: 1121 CSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF 1180
            CSAGVGRTGV I   +++  + +   V++   +++LR QR  M+QT  QY+F Y+  +++
Sbjct: 1844 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1903

Query: 1181 L 1181
            L
Sbjct: 1904 L 1904



 Score =  148 bits (373), Expect = 3e-35
 Identities = 94/280 (33%), Positives = 146/280 (52%), Gaps = 21/280 (7%)

Query: 903  KLEEGMVFT-EYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTG 961
            K  + + F+ EYE I   +    +  + L  N  ++R   V+ Y+ +RV L+   E   G
Sbjct: 1350 KANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPG 1407

Query: 962  --YINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKS 1019
              Y+NA++I       +  YIATQG LP T  DFW+M+WEQ    + M+T  EE  R K 
Sbjct: 1408 SDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKC 1465

Query: 1020 HRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPD 1079
             +YWP  G++    T+G  +VT     +   Y      +    S ++R V   Q+T WPD
Sbjct: 1466 DQYWPSRGTE----THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPD 1521

Query: 1080 HGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIY 1139
            HG PE    FL++L  +++                 P+VVHCSAGVGRTG  I+ + M+ 
Sbjct: 1522 HGVPEHPTPFLAFLRRVKTCNPPDAG----------PMVVHCSAGVGRTGCFIVIDAMLE 1571

Query: 1140 CLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
             ++H + V++   + L+R QR +M+QT  QY F++  L++
Sbjct: 1572 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE 1611


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  168 bits (426), Expect = 2e-41
 Identities = 104/301 (34%), Positives = 157/301 (52%), Gaps = 22/301 (7%)

Query: 889  TRVPMDERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIRE 941
            T VP    +  ++K  ++E G   T    E++++   KA+   F +A LP N  ++R+  
Sbjct: 1605 TEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVN 1664

Query: 942  VVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQ 1000
            ++PYE  RV L P +    + YINAS I       +  YIATQGPL  T  DFW+M+WE 
Sbjct: 1665 IMPYESTRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEH 1722

Query: 1001 GVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKH 1060
               ++ M+T   E GR K H+YWP       SA Y  F V      +   Y     KV  
Sbjct: 1723 NSTIVVMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTD 1778

Query: 1061 LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVH 1120
               GQ RTV   Q+TDWP+ G P+  +GF+ ++ ++   +            +  PI VH
Sbjct: 1779 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVH 1830

Query: 1121 CSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF 1180
            CSAGVGRTGV I   +++  + +   V++   +++LR QR  M+QT  QY+F Y+  +++
Sbjct: 1831 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1890

Query: 1181 L 1181
            L
Sbjct: 1891 L 1891



 Score =  148 bits (373), Expect = 3e-35
 Identities = 94/280 (33%), Positives = 146/280 (52%), Gaps = 21/280 (7%)

Query: 903  KLEEGMVFT-EYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTG 961
            K  + + F+ EYE I   +    +  + L  N  ++R   V+ Y+ +RV L+   E   G
Sbjct: 1337 KANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPG 1394

Query: 962  --YINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKS 1019
              Y+NA++I       +  YIATQG LP T  DFW+M+WEQ    + M+T  EE  R K 
Sbjct: 1395 SDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKC 1452

Query: 1020 HRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPD 1079
             +YWP  G++    T+G  +VT     +   Y      +    S ++R V   Q+T WPD
Sbjct: 1453 DQYWPSRGTE----THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPD 1508

Query: 1080 HGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIY 1139
            HG PE    FL++L  +++                 P+VVHCSAGVGRTG  I+ + M+ 
Sbjct: 1509 HGVPEHPTPFLAFLRRVKTCNPPDAG----------PMVVHCSAGVGRTGCFIVIDAMLE 1558

Query: 1140 CLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
             ++H + V++   + L+R QR +M+QT  QY F++  L++
Sbjct: 1559 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE 1598


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  168 bits (426), Expect = 2e-41
 Identities = 104/301 (34%), Positives = 157/301 (52%), Gaps = 22/301 (7%)

Query: 889  TRVPMDERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIRE 941
            T VP    +  ++K  ++E G   T    E++++   KA+   F +A LP N  ++R+  
Sbjct: 1609 TEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVN 1668

Query: 942  VVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQ 1000
            ++PYE  RV L P +    + YINAS I       +  YIATQGPL  T  DFW+M+WE 
Sbjct: 1669 IMPYESTRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEH 1726

Query: 1001 GVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKH 1060
               ++ M+T   E GR K H+YWP       SA Y  F V      +   Y     KV  
Sbjct: 1727 NSTIVVMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTD 1782

Query: 1061 LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVH 1120
               GQ RTV   Q+TDWP+ G P+  +GF+ ++ ++   +            +  PI VH
Sbjct: 1783 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVH 1834

Query: 1121 CSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF 1180
            CSAGVGRTGV I   +++  + +   V++   +++LR QR  M+QT  QY+F Y+  +++
Sbjct: 1835 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1894

Query: 1181 L 1181
            L
Sbjct: 1895 L 1895



 Score =  148 bits (373), Expect = 3e-35
 Identities = 94/280 (33%), Positives = 146/280 (52%), Gaps = 21/280 (7%)

Query: 903  KLEEGMVFT-EYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTG 961
            K  + + F+ EYE I   +    +  + L  N  ++R   V+ Y+ +RV L+   E   G
Sbjct: 1341 KANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPG 1398

Query: 962  --YINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKS 1019
              Y+NA++I       +  YIATQG LP T  DFW+M+WEQ    + M+T  EE  R K 
Sbjct: 1399 SDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKC 1456

Query: 1020 HRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPD 1079
             +YWP  G++    T+G  +VT     +   Y      +    S ++R V   Q+T WPD
Sbjct: 1457 DQYWPSRGTE----THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPD 1512

Query: 1080 HGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIY 1139
            HG PE    FL++L  +++                 P+VVHCSAGVGRTG  I+ + M+ 
Sbjct: 1513 HGVPEHPTPFLAFLRRVKTCNPPDAG----------PMVVHCSAGVGRTGCFIVIDAMLE 1562

Query: 1140 CLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
             ++H + V++   + L+R QR +M+QT  QY F++  L++
Sbjct: 1563 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE 1602


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,464,308
Number of Sequences: 37866
Number of extensions: 2404830
Number of successful extensions: 12554
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 152
Number of HSP's successfully gapped in prelim test: 144
Number of HSP's that attempted gapping in prelim test: 11455
Number of HSP's gapped (non-prelim): 797
length of query: 1187
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1074
effective length of database: 13,968,660
effective search space: 15002340840
effective search space used: 15002340840
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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