BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [Homo sapiens] (1187 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 2404 0.0 gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 1222 0.0 gi|223941891 protein tyrosine phosphatase, non-receptor type 3 i... 214 3e-55 gi|223941888 protein tyrosine phosphatase, non-receptor type 3 i... 214 3e-55 gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 214 3e-55 gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 214 3e-55 gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 214 3e-55 gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 214 3e-55 gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 203 9e-52 gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is... 177 7e-44 gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is... 177 7e-44 gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is... 177 7e-44 gi|109138573 protein tyrosine phosphatase, non-receptor type 20A... 175 2e-43 gi|109138561 protein tyrosine phosphatase, non-receptor type 20A... 175 2e-43 gi|109138557 protein tyrosine phosphatase, non-receptor type 20A... 175 2e-43 gi|108802617 protein tyrosine phosphatase, non-receptor type 20 ... 175 2e-43 gi|108802607 protein tyrosine phosphatase, non-receptor type 20 ... 175 2e-43 gi|108802604 protein tyrosine phosphatase, non-receptor type 20 ... 175 2e-43 gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 171 4e-42 gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 171 4e-42 gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 171 4e-42 gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 171 4e-42 gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 170 8e-42 gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 170 8e-42 gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 170 8e-42 gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 170 8e-42 gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 168 2e-41 gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 168 2e-41 gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 168 2e-41 gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 168 2e-41 >gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [Homo sapiens] Length = 1187 Score = 2404 bits (6230), Expect = 0.0 Identities = 1187/1187 (100%), Positives = 1187/1187 (100%) Query: 1 MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH 60 MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH Sbjct: 1 MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH 60 Query: 61 YFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYL 120 YFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYL Sbjct: 61 YFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYL 120 Query: 121 QVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLE 180 QVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLE Sbjct: 121 QVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLE 180 Query: 181 ELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIF 240 ELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIF Sbjct: 181 ELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIF 240 Query: 241 VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHK 300 VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHK Sbjct: 241 VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHK 300 Query: 301 FYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFH 360 FYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFH Sbjct: 301 FYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFH 360 Query: 361 GNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDI 420 GNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDI Sbjct: 361 GNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDI 420 Query: 421 MRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQP 480 MRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQP Sbjct: 421 MRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQP 480 Query: 481 EDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTP 540 EDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTP Sbjct: 481 EDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTP 540 Query: 541 ELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTR 600 ELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTR Sbjct: 541 ELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTR 600 Query: 601 KVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKS 660 KVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKS Sbjct: 601 KVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKS 660 Query: 661 LHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPES 720 LHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPES Sbjct: 661 LHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPES 720 Query: 721 VPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARV 780 VPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARV Sbjct: 721 VPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARV 780 Query: 781 LRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSI 840 LRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSI Sbjct: 781 LRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSI 840 Query: 841 IEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTL 900 IEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTL Sbjct: 841 IEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTL 900 Query: 901 KKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNT 960 KKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNT Sbjct: 901 KKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNT 960 Query: 961 GYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSH 1020 GYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSH Sbjct: 961 GYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSH 1020 Query: 1021 RYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDH 1080 RYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDH Sbjct: 1021 RYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDH 1080 Query: 1081 GCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYC 1140 GCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYC Sbjct: 1081 GCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYC 1140 Query: 1141 LEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI 1187 LEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI Sbjct: 1141 LEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI 1187 >gi|150418005 protein tyrosine phosphatase, non-receptor type 21 [Homo sapiens] Length = 1174 Score = 1222 bits (3161), Expect = 0.0 Identities = 658/1216 (54%), Positives = 870/1216 (71%), Gaps = 73/1216 (6%) Query: 1 MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH 60 +PFGLKL+RTRRY V SK+C V RI+LL++ +E TLSVESTGQE LEAVAQRLELRE Sbjct: 3 LPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVT 62 Query: 61 YFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYL 120 YF LW+ +K Q RWV+LEKPLKK LDK+A EP ++FGV+FYVP+VS LQQE TRYQYYL Sbjct: 63 YFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYL 122 Query: 121 QVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLE 180 Q+KKD+LEG + CTL+Q I+LAGLAVQADFGD++Q++SQDFL+++ LFP+ +E VLE Sbjct: 123 QLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLE 182 Query: 181 ELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIF 240 E TQKVA H+ + G+ +AE++Y+ EVER+DG+G+E +P KD+ G+ + +G GIF Sbjct: 183 EATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIF 242 Query: 241 VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHK 300 V+++ GR V++RW+D+ N++HNKS +EL NKEET F T+D+E AKYI RL RHK Sbjct: 243 VKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVARHK 302 Query: 301 FYKQNKICTE-QSNSPPPIRRQPTWSRSSLPRQQPYIL-PPVHVQCGEHYSETH-TSQDS 357 FY+ N+ + Q+ + PIRR+ + SR SLP+ QPY++ PP + HY+E + +SQD+ Sbjct: 303 FYRLNQCNLQTQTVTVNPIRRRSS-SRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQDN 361 Query: 358 IFHGNEEALYCNSHNSLDLNY--LNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSI 415 +F N+ YC+S SLD LNG + NGSV S HS NSLN Q ++Q SP+SSN SI Sbjct: 362 LFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPSI 421 Query: 416 PGSDIMRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTH 475 GSD+MR DY+PSHRHSA+I PSYRPTPDYETVM+Q+ RG++H + QS SLRNLNI +++ Sbjct: 422 TGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSSY 481 Query: 476 AYNQPEDLVYSQPEMRERHPYTVPYGPQGVY--SNKLVSPSDQRNPKNNVVPSKPGASAI 533 AY++P LVYSQPE+RE P + S SPS P +P A Sbjct: 482 AYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAER----RPVVGA- 536 Query: 534 SHTVSTPELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGS 593 VS PEL N QLQ + +Y + ++++ ++RPPPPYP PRPA STPDL+ RH Y+S S Sbjct: 537 ---VSVPELTNAQLQ-AQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLS--RHLYISSS 590 Query: 594 SPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGM 653 +PDL+TR+V SV+TFQEDS PV H SLQEVSEPLTA + H ++KR+S+EV + G+ Sbjct: 591 NPDLITRRVHHSVQTFQEDSLPVAH-SLQEVSEPLTAAR-HAQLHKRNSIEVA-GLSHGL 647 Query: 654 EAMTLKSLHL-----------------PMARRNTLREQGPPEEGSGSHEVPQLPQYHHKK 696 E + LK L P + +G PEE G +Y HKK Sbjct: 648 EGLRLKERTLSASAAEVAPRAVSVGSQPSVFTERTQREG-PEEAEGL-------RYGHKK 699 Query: 697 TFSDATMLIHSSESEEEEEEAPESVPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPR 756 + SDATMLIHSSE EE+E+ ES + P R + + + LA+ P PG Sbjct: 700 SLSDATMLIHSSEEEEDEDFEEESGARAPPARAR-----EPRPGLAQDP-------PGCP 747 Query: 757 KSVSNGALR--QDQASLPPAMARARVLRHGPAKAISMSRTDPPAVNGASLGPSISEPDL- 813 + + G L + +A +P A R++ P + + + P +G L PS+SE DL Sbjct: 748 RVLLAGPLHILEPKAHVPD--AEKRMMDSSPVR--TTAEAQRPWRDGL-LMPSMSESDLT 802 Query: 814 TSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMAGLEAQK-RPLMLAALNG 872 TS + R +++ +K+RPVS++ S + +I+E + ++K + ++A+K PL LAALNG Sbjct: 803 TSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMKKTR---VDAKKIGPLKLAALNG 859 Query: 873 LSVARVSGREENRVDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKK-ANGIFSTAALP 931 LS++RV +E + ATR DER + L+++LE+GMVFTEYE+I KK+ +G STA LP Sbjct: 860 LSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTARLP 919 Query: 932 ENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEWHYIATQGPLPHTCH 991 ENAER+R ++V+PY++ RVEL+PTKENNTGYINASHIKV V G EW YIATQGPL +TC Sbjct: 920 ENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQ 979 Query: 992 DFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCY 1051 DFWQMVWEQG+ +IAMVTAEEEGGR KS RYWP+LGS+H++ TYG+FK+TT+FRTDS CY Sbjct: 980 DFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCY 1039 Query: 1052 ATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTK 1111 ATTGLK+KHLL+GQERTVWHLQYTDWP+HGCPED++GFLSYLEEIQSVRRHTNS + + Sbjct: 1040 ATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSD-PQ 1098 Query: 1112 NRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYK 1171 + +PP++VHCSAGVGRTGV+ILSE+MI CLEHNE +++P +L +LR+QRM ++QT+ QY Sbjct: 1099 SPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYT 1158 Query: 1172 FVYQVLIQFLQNSRLI 1187 FVY+VLIQFL++SRLI Sbjct: 1159 FVYRVLIQFLKSSRLI 1174 >gi|223941891 protein tyrosine phosphatase, non-receptor type 3 isoform 6 [Homo sapiens] Length = 581 Score = 214 bits (546), Expect = 3e-55 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%) Query: 900 LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959 LKK LE G V ++EQ+ +KK + A LP+N +++R ++V+PY+ RV L + N Sbjct: 305 LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 360 Query: 960 TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS++ + + A YIATQGPLPHTC FWQ+VW+Q +++I M+T E GRT Sbjct: 361 EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 420 Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077 K H+YWP +G F + + ++ Y + + V + +G+E TV HLQY W Sbjct: 421 KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 477 Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137 PDHG P+D FL ++ ++S+R + P++VHCSAG+GRTGVL+ E Sbjct: 478 PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 526 Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179 + E N + ++R +R+QR M+QT +QYKFV + +++ Sbjct: 527 MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 568 >gi|223941888 protein tyrosine phosphatase, non-receptor type 3 isoform 5 [Homo sapiens] Length = 626 Score = 214 bits (546), Expect = 3e-55 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%) Query: 900 LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959 LKK LE G V ++EQ+ +KK + A LP+N +++R ++V+PY+ RV L + N Sbjct: 350 LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 405 Query: 960 TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS++ + + A YIATQGPLPHTC FWQ+VW+Q +++I M+T E GRT Sbjct: 406 EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 465 Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077 K H+YWP +G F + + ++ Y + + V + +G+E TV HLQY W Sbjct: 466 KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 522 Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137 PDHG P+D FL ++ ++S+R + P++VHCSAG+GRTGVL+ E Sbjct: 523 PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 571 Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179 + E N + ++R +R+QR M+QT +QYKFV + +++ Sbjct: 572 MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 613 >gi|223941885 protein tyrosine phosphatase, non-receptor type 3 isoform 4 [Homo sapiens] Length = 737 Score = 214 bits (546), Expect = 3e-55 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%) Query: 900 LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959 LKK LE G V ++EQ+ +KK + A LP+N +++R ++V+PY+ RV L + N Sbjct: 461 LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 516 Query: 960 TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS++ + + A YIATQGPLPHTC FWQ+VW+Q +++I M+T E GRT Sbjct: 517 EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 576 Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077 K H+YWP +G F + + ++ Y + + V + +G+E TV HLQY W Sbjct: 577 KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 633 Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137 PDHG P+D FL ++ ++S+R + P++VHCSAG+GRTGVL+ E Sbjct: 634 PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 682 Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179 + E N + ++R +R+QR M+QT +QYKFV + +++ Sbjct: 683 MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 724 Score = 78.2 bits (191), Expect = 4e-14 Identities = 70/303 (23%), Positives = 130/303 (42%), Gaps = 22/303 (7%) Query: 125 DVLEGRLRCTLDQVIRLAGLAVQADFGDYNQ-FDSQDFLREYVLFPMDLALEEAVLEELT 183 D+ EGRL C L+ + LA AVQ+ FGDYN +L + P E+ Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQN-------EDFL 54 Query: 184 QKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRN 243 KV H+ HSG+ +EAE YIN LD +G E+ +D H + +GI G+ V Sbjct: 55 TKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR 114 Query: 244 RIGRQAVIYRWNDMGNITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATR 298 + + Y W ++ I+ + + + ++E F+ + + K + + Sbjct: 115 KYICTS-FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEH 173 Query: 299 HKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSI 358 H F++ K+ ++ N + + T + ++ P + ++ H S + + + Sbjct: 174 HTFFQAKKLLPQEKN---VLSQYWTMGSRNTKKRSPRLRH--EIRKPRHSSADNLANEMT 228 Query: 359 FHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFI---QASPVSSNLSI 415 + E ++ SL + V+ S++ N +QS++ +S VS + + Sbjct: 229 YITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNA 288 Query: 416 PGS 418 PGS Sbjct: 289 PGS 291 >gi|223941882 protein tyrosine phosphatase, non-receptor type 3 isoform 3 [Homo sapiens] Length = 782 Score = 214 bits (546), Expect = 3e-55 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%) Query: 900 LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959 LKK LE G V ++EQ+ +KK + A LP+N +++R ++V+PY+ RV L + N Sbjct: 506 LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 561 Query: 960 TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS++ + + A YIATQGPLPHTC FWQ+VW+Q +++I M+T E GRT Sbjct: 562 EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 621 Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077 K H+YWP +G F + + ++ Y + + V + +G+E TV HLQY W Sbjct: 622 KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 678 Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137 PDHG P+D FL ++ ++S+R + P++VHCSAG+GRTGVL+ E Sbjct: 679 PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 727 Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179 + E N + ++R +R+QR M+QT +QYKFV + +++ Sbjct: 728 MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 769 Score = 74.3 bits (181), Expect = 6e-13 Identities = 52/195 (26%), Positives = 88/195 (45%), Gaps = 14/195 (7%) Query: 125 DVLEGRLRCTLDQVIRLAGLAVQADFGDYNQ-FDSQDFLREYVLFPMDLALEEAVLEELT 183 D+ EGRL C L+ + LA AVQ+ FGDYN +L + P E+ Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQN-------EDFL 54 Query: 184 QKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRN 243 KV H+ HSG+ +EAE YIN LD +G E+ +D H + +GI G+ V Sbjct: 55 TKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR 114 Query: 244 RIGRQAVIYRWNDMGNITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATR 298 + + Y W ++ I+ + + + ++E F+ + + K + + Sbjct: 115 KYICTS-FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEH 173 Query: 299 HKFYKQNKICTEQSN 313 H F++ K+ ++ N Sbjct: 174 HTFFQAKKLLPQEKN 188 >gi|223941879 protein tyrosine phosphatase, non-receptor type 3 isoform 2 [Homo sapiens] Length = 868 Score = 214 bits (546), Expect = 3e-55 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%) Query: 900 LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959 LKK LE G V ++EQ+ +KK + A LP+N +++R ++V+PY+ RV L + N Sbjct: 592 LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 647 Query: 960 TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS++ + + A YIATQGPLPHTC FWQ+VW+Q +++I M+T E GRT Sbjct: 648 EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 707 Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077 K H+YWP +G F + + ++ Y + + V + +G+E TV HLQY W Sbjct: 708 KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 764 Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137 PDHG P+D FL ++ ++S+R + P++VHCSAG+GRTGVL+ E Sbjct: 765 PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 813 Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179 + E N + ++R +R+QR M+QT +QYKFV + +++ Sbjct: 814 MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 855 Score = 132 bits (333), Expect = 1e-30 Identities = 108/407 (26%), Positives = 185/407 (45%), Gaps = 24/407 (5%) Query: 22 VTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQA-RWVELEK 80 + I LD V ++ + TGQ L+ V L + E YFGL S + RW+E K Sbjct: 30 ICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASK 89 Query: 81 PLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIR 140 ++K L K L F V F++P+ + LQQE TR+ Y+LQ+K D+ EGRL C L+ + Sbjct: 90 AIRKQL-KGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVV 148 Query: 141 LAGLAVQADFGDYN-QFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPA 199 LA AVQ+ FGDYN +L + P E+ KV H+ HSG+ + Sbjct: 149 LASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ-------NEDFLTKVESLHEQHSGLKQS 201 Query: 200 EAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGN 259 EAE YIN LD +G E+ +D H + +GI G+ V + + Y W ++ Sbjct: 202 EAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS-FYPWVNILK 260 Query: 260 ITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATRHKFYKQNKICTEQSNS 314 I+ + + + ++E F+ + + K + + H F++ K+ ++ N Sbjct: 261 ISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKN- 319 Query: 315 PPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFHGNEEALYCNSHNSL 374 + + T + ++ P + ++ H S + + + + E ++ SL Sbjct: 320 --VLSQYWTMGSRNTKKRSPRLRH--EIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 375 Query: 375 DLNYLNGTVTNGSVCSVHSVNSLNCSQSFI---QASPVSSNLSIPGS 418 + V+ S++ N +QS++ +S VS + + PGS Sbjct: 376 APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS 422 >gi|223941876 protein tyrosine phosphatase, non-receptor type 3 isoform 1 [Homo sapiens] Length = 913 Score = 214 bits (546), Expect = 3e-55 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%) Query: 900 LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959 LKK LE G V ++EQ+ +KK + A LP+N +++R ++V+PY+ RV L + N Sbjct: 637 LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 692 Query: 960 TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS++ + + A YIATQGPLPHTC FWQ+VW+Q +++I M+T E GRT Sbjct: 693 EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 752 Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077 K H+YWP +G F + + ++ Y + + V + +G+E TV HLQY W Sbjct: 753 KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 809 Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137 PDHG P+D FL ++ ++S+R + P++VHCSAG+GRTGVL+ E Sbjct: 810 PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 858 Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179 + E N + ++R +R+QR M+QT +QYKFV + +++ Sbjct: 859 MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 900 Score = 129 bits (323), Expect = 2e-29 Identities = 90/299 (30%), Positives = 143/299 (47%), Gaps = 16/299 (5%) Query: 22 VTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQA-RWVELEK 80 + I LD V ++ + TGQ L+ V L + E YFGL S + RW+E K Sbjct: 30 ICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASK 89 Query: 81 PLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIR 140 ++K L K L F V F++P+ + LQQE TR+ Y+LQ+K D+ EGRL C L+ + Sbjct: 90 AIRKQL-KGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVV 148 Query: 141 LAGLAVQADFGDYN-QFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPA 199 LA AVQ+ FGDYN +L + P E+ KV H+ HSG+ + Sbjct: 149 LASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ-------NEDFLTKVESLHEQHSGLKQS 201 Query: 200 EAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGN 259 EAE YIN LD +G E+ +D H + +GI G+ V + + Y W ++ Sbjct: 202 EAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS-FYPWVNILK 260 Query: 260 ITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATRHKFYKQNKICTEQSN 313 I+ + + + ++E F+ + + K + + H F++ K+ ++ N Sbjct: 261 ISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKN 319 >gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo sapiens] Length = 926 Score = 203 bits (516), Expect = 9e-52 Identities = 106/282 (37%), Positives = 164/282 (58%), Gaps = 19/282 (6%) Query: 900 LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959 L + L G V T+++Q+ +KK S A LP+N ++R R++ PY+ RV L + N Sbjct: 646 LAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVIL----KGN 701 Query: 960 TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINA++I + + + YIA QGPLPHTC DFWQM WEQG +++ M+T + E GR Sbjct: 702 EDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRV 761 Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077 K H+YWP+ S++YG ++VT + Y + + + + R + +QY W Sbjct: 762 KCHQYWPE---PTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAW 818 Query: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137 PDHG P+D FL ++ +++ R + P+VVHCSAG+GRTGVLI E Sbjct: 819 PDHGVPDDSSDFLDFVCHVRNKR----------AGKEEPVVVHCSAGIGRTGVLITMETA 868 Query: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179 + +E N+ V ++R +R+QR MIQT +QY+FV + +++ Sbjct: 869 MCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK 910 Score = 136 bits (343), Expect = 1e-31 Identities = 93/300 (31%), Positives = 150/300 (50%), Gaps = 18/300 (6%) Query: 22 VTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKS-QQARWVELEK 80 V I LLD+ V ++ GQ L+ V + L+L E YFGL S RW++ K Sbjct: 30 VCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNK 89 Query: 81 PLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIR 140 P++K L K + L F V F+V + + LQ+E TRYQY+LQ+K+D+L GRL C + Sbjct: 90 PIRKQL-KRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAAL 148 Query: 141 LAGLAVQADFGDYNQFDS-QDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPA 199 LA AVQ++ GDY+Q ++ +L +Y P ++ +++A+ H+ H G+ PA Sbjct: 149 LASFAVQSELGDYDQSENLSGYLSDYSFIPNQ-------PQDFEKEIAKLHQQHIGLSPA 201 Query: 200 EAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFV-RNRIGRQAVIYRWNDMG 258 EAE Y+N L+ +G E +D N + +G+ GI + +NR+ + W + Sbjct: 202 EAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNT--FPWLKIV 259 Query: 259 NITHNKSTILV----ELINKEETAL-FHTDDIENAKYISRLFATRHKFYKQNKICTEQSN 313 I+ + EL ET L F+ + K + + H F++ ++ Q N Sbjct: 260 KISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKN 319 >gi|18104993 protein tyrosine phosphatase, non-receptor type 6 isoform 3 [Homo sapiens] Length = 624 Score = 177 bits (448), Expect = 7e-44 Identities = 110/317 (34%), Positives = 173/317 (54%), Gaps = 30/317 (9%) Query: 888 ATRV---PMDERFRTLKKKLE-----EGMVFTEYEQIPKKKANGIFST--AALPENAERS 937 ATRV ++ R L KK E + + E+E + K++ + PEN ++ Sbjct: 215 ATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKN 274 Query: 938 RIREVVPYEENRVELIPTKENNTG--YINASHIKVVVGGAEWH---YIATQGPLPHTCHD 992 R + ++P++ +RV L N G YINA++IK + G + + YIA+QG L T +D Sbjct: 275 RYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVND 334 Query: 993 FWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYA 1052 FWQM W++ VI M T E E GR K YWP++G + + YG + VT D+ Y Sbjct: 335 FWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRA---YGPYSVTNCGEHDTTEYK 391 Query: 1053 TTGLKVKHLLSGQ-ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTK 1111 L+V L +G R +WH QY WPDHG P + G LS+L++I N E Sbjct: 392 LRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-------NQRQESLP 444 Query: 1112 NRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNE---KVEVPMMLRLLREQRMFMIQTIA 1168 + PI+VHCSAG+GRTG +I+ ++++ + +++ ++++R QR M+QT A Sbjct: 445 HA-GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEA 503 Query: 1169 QYKFVYQVLIQFLQNSR 1185 QYKF+Y + QF++ ++ Sbjct: 504 QYKFIYVAIAQFIETTK 520 >gi|18104989 protein tyrosine phosphatase, non-receptor type 6 isoform 1 [Homo sapiens] Length = 595 Score = 177 bits (448), Expect = 7e-44 Identities = 110/317 (34%), Positives = 173/317 (54%), Gaps = 30/317 (9%) Query: 888 ATRV---PMDERFRTLKKKLE-----EGMVFTEYEQIPKKKANGIFST--AALPENAERS 937 ATRV ++ R L KK E + + E+E + K++ + PEN ++ Sbjct: 215 ATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKN 274 Query: 938 RIREVVPYEENRVELIPTKENNTG--YINASHIKVVVGGAEWH---YIATQGPLPHTCHD 992 R + ++P++ +RV L N G YINA++IK + G + + YIA+QG L T +D Sbjct: 275 RYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVND 334 Query: 993 FWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYA 1052 FWQM W++ VI M T E E GR K YWP++G + + YG + VT D+ Y Sbjct: 335 FWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRA---YGPYSVTNCGEHDTTEYK 391 Query: 1053 TTGLKVKHLLSGQ-ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTK 1111 L+V L +G R +WH QY WPDHG P + G LS+L++I N E Sbjct: 392 LRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-------NQRQESLP 444 Query: 1112 NRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNE---KVEVPMMLRLLREQRMFMIQTIA 1168 + PI+VHCSAG+GRTG +I+ ++++ + +++ ++++R QR M+QT A Sbjct: 445 HA-GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEA 503 Query: 1169 QYKFVYQVLIQFLQNSR 1185 QYKF+Y + QF++ ++ Sbjct: 504 QYKFIYVAIAQFIETTK 520 >gi|18104991 protein tyrosine phosphatase, non-receptor type 6 isoform 2 [Homo sapiens] Length = 597 Score = 177 bits (448), Expect = 7e-44 Identities = 110/317 (34%), Positives = 173/317 (54%), Gaps = 30/317 (9%) Query: 888 ATRV---PMDERFRTLKKKLE-----EGMVFTEYEQIPKKKANGIFST--AALPENAERS 937 ATRV ++ R L KK E + + E+E + K++ + PEN ++ Sbjct: 217 ATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKN 276 Query: 938 RIREVVPYEENRVELIPTKENNTG--YINASHIKVVVGGAEWH---YIATQGPLPHTCHD 992 R + ++P++ +RV L N G YINA++IK + G + + YIA+QG L T +D Sbjct: 277 RYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVND 336 Query: 993 FWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYA 1052 FWQM W++ VI M T E E GR K YWP++G + + YG + VT D+ Y Sbjct: 337 FWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRA---YGPYSVTNCGEHDTTEYK 393 Query: 1053 TTGLKVKHLLSGQ-ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTK 1111 L+V L +G R +WH QY WPDHG P + G LS+L++I N E Sbjct: 394 LRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-------NQRQESLP 446 Query: 1112 NRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNE---KVEVPMMLRLLREQRMFMIQTIA 1168 + PI+VHCSAG+GRTG +I+ ++++ + +++ ++++R QR M+QT A Sbjct: 447 HA-GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEA 505 Query: 1169 QYKFVYQVLIQFLQNSR 1185 QYKF+Y + QF++ ++ Sbjct: 506 QYKFIYVAIAQFIETTK 522 >gi|109138573 protein tyrosine phosphatase, non-receptor type 20A isoform 8 [Homo sapiens] Length = 339 Score = 175 bits (444), Expect = 2e-43 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%) Query: 898 RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957 + L++K + E+ + K G F++ P N E++R R+++PY+ RV L +K+ Sbjct: 67 KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 126 Query: 958 NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS+I++V G E+ YIATQGPL T DFWQMV E NVIAM+T E EGG Sbjct: 127 ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 182 Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072 K + YWP L KH +++ F +V +G +V L Sbjct: 183 KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 235 Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132 Q+T WPDHG P F+ Y +R S L G P+VVHCSAG+GRTGV + Sbjct: 236 QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 283 Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182 +++ + N + ++ +REQR M+QT QY F Y ++++ L+ Sbjct: 284 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 333 >gi|109138561 protein tyrosine phosphatase, non-receptor type 20A isoform 3 [Homo sapiens] Length = 411 Score = 175 bits (444), Expect = 2e-43 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%) Query: 898 RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957 + L++K + E+ + K G F++ P N E++R R+++PY+ RV L +K+ Sbjct: 139 KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 198 Query: 958 NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS+I++V G E+ YIATQGPL T DFWQMV E NVIAM+T E EGG Sbjct: 199 ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 254 Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072 K + YWP L KH +++ F +V +G +V L Sbjct: 255 KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 307 Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132 Q+T WPDHG P F+ Y +R S L G P+VVHCSAG+GRTGV + Sbjct: 308 QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 355 Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182 +++ + N + ++ +REQR M+QT QY F Y ++++ L+ Sbjct: 356 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 405 >gi|109138557 protein tyrosine phosphatase, non-receptor type 20A isoform 1 [Homo sapiens] Length = 420 Score = 175 bits (444), Expect = 2e-43 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%) Query: 898 RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957 + L++K + E+ + K G F++ P N E++R R+++PY+ RV L +K+ Sbjct: 148 KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 207 Query: 958 NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS+I++V G E+ YIATQGPL T DFWQMV E NVIAM+T E EGG Sbjct: 208 ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 263 Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072 K + YWP L KH +++ F +V +G +V L Sbjct: 264 KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 316 Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132 Q+T WPDHG P F+ Y +R S L G P+VVHCSAG+GRTGV + Sbjct: 317 QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 364 Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182 +++ + N + ++ +REQR M+QT QY F Y ++++ L+ Sbjct: 365 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 414 >gi|108802617 protein tyrosine phosphatase, non-receptor type 20 isoform 8 [Homo sapiens] Length = 339 Score = 175 bits (444), Expect = 2e-43 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%) Query: 898 RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957 + L++K + E+ + K G F++ P N E++R R+++PY+ RV L +K+ Sbjct: 67 KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 126 Query: 958 NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS+I++V G E+ YIATQGPL T DFWQMV E NVIAM+T E EGG Sbjct: 127 ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 182 Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072 K + YWP L KH +++ F +V +G +V L Sbjct: 183 KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 235 Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132 Q+T WPDHG P F+ Y +R S L G P+VVHCSAG+GRTGV + Sbjct: 236 QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 283 Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182 +++ + N + ++ +REQR M+QT QY F Y ++++ L+ Sbjct: 284 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 333 >gi|108802607 protein tyrosine phosphatase, non-receptor type 20 isoform 3 [Homo sapiens] Length = 411 Score = 175 bits (444), Expect = 2e-43 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%) Query: 898 RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957 + L++K + E+ + K G F++ P N E++R R+++PY+ RV L +K+ Sbjct: 139 KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 198 Query: 958 NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS+I++V G E+ YIATQGPL T DFWQMV E NVIAM+T E EGG Sbjct: 199 ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 254 Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072 K + YWP L KH +++ F +V +G +V L Sbjct: 255 KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 307 Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132 Q+T WPDHG P F+ Y +R S L G P+VVHCSAG+GRTGV + Sbjct: 308 QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 355 Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182 +++ + N + ++ +REQR M+QT QY F Y ++++ L+ Sbjct: 356 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 405 >gi|108802604 protein tyrosine phosphatase, non-receptor type 20 isoform 1 [Homo sapiens] Length = 420 Score = 175 bits (444), Expect = 2e-43 Identities = 104/290 (35%), Positives = 152/290 (52%), Gaps = 28/290 (9%) Query: 898 RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957 + L++K + E+ + K G F++ P N E++R R+++PY+ RV L +K+ Sbjct: 148 KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD 207 Query: 958 NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 YINAS+I++V G E+ YIATQGPL T DFWQMV E NVIAM+T E EGG Sbjct: 208 ----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII 263 Query: 1018 KSHRYWP-----KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHL 1072 K + YWP L KH +++ F +V +G +V L Sbjct: 264 KCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQL 316 Query: 1073 QYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI 1132 Q+T WPDHG P F+ Y +R S L G P+VVHCSAG+GRTGV + Sbjct: 317 QFTKWPDHGTPASADSFIKY------IRYARKSHLTG------PMVVHCSAGIGRTGVFL 364 Query: 1133 LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ 1182 +++ + N + ++ +REQR M+QT QY F Y ++++ L+ Sbjct: 365 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 414 >gi|18375650 protein tyrosine phosphatase, non-receptor type 13 isoform 4 [Homo sapiens] Length = 2490 Score = 171 bits (433), Expect = 4e-42 Identities = 98/287 (34%), Positives = 153/287 (53%), Gaps = 23/287 (8%) Query: 898 RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957 R L+ L++G+ E E + + K EN ++R + ++PY+ RV L Sbjct: 2207 RVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPL----G 2262 Query: 958 NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 + GYINAS IK+ VG E+ YIA QGPLP T DFWQM+WEQ VIAM+T E EG + Sbjct: 2263 DEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKI 2322 Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077 K RYWP + K ++ + ++ + + ++ + + + R + HL +T W Sbjct: 2323 KCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAW 2381 Query: 1078 PDHGC---PEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILS 1134 PDH P+D+ F+SY+ I +R PI+ HCSAG+GR+G LI Sbjct: 2382 PDHDTPSQPDDLLTFISYMRHI---------------HRSGPIITHCSAGIGRSGTLICI 2426 Query: 1135 ELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181 ++++ + + ++ ++R +R QR M+QT QY F YQV++ L Sbjct: 2427 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2473 Score = 100 bits (249), Expect = 8e-21 Identities = 86/314 (27%), Positives = 142/314 (45%), Gaps = 37/314 (11%) Query: 25 IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGL-------WF-------LSKS 70 I LL+ +E T ++ ++ + V + L E H F L +F L+K Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKV 635 Query: 71 QQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGR 130 W E K K F LFF + F++ +VS +Q T +QYYLQ++KD+LE R Sbjct: 636 APEGWKEEPKKKTKATVNFT----LFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEER 691 Query: 131 LRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQE- 189 + C + + LA LA+QA++GDY Q + F M+ L V+E+L +E Sbjct: 692 MHCDDETSLLLASLALQAEYGDY-----QPEVHGVSYFRMEHYLPARVMEKLDLSYIKEE 746 Query: 190 ----HKAHSGILPAEAELMYINEVERLDGFG---QEIFPVKDNHGNCVHLGIFFMGIF-- 240 H + G E EL ++ +RL +G + P K + + LG+ G+ Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTG-ILLGVCSKGVLVF 805 Query: 241 -VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRH 299 V N + + + W + I+ +K I ++ + F TD+ + +Y+ L + +H Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQH 865 Query: 300 KFYKQNKICTEQSN 313 KF Q + QSN Sbjct: 866 KFQLQMR--ARQSN 877 >gi|18375648 protein tyrosine phosphatase, non-receptor type 13 isoform 3 [Homo sapiens] Length = 2294 Score = 171 bits (433), Expect = 4e-42 Identities = 98/287 (34%), Positives = 153/287 (53%), Gaps = 23/287 (8%) Query: 898 RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957 R L+ L++G+ E E + + K EN ++R + ++PY+ RV L Sbjct: 2011 RVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPL----G 2066 Query: 958 NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 + GYINAS IK+ VG E+ YIA QGPLP T DFWQM+WEQ VIAM+T E EG + Sbjct: 2067 DEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKI 2126 Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077 K RYWP + K ++ + ++ + + ++ + + + R + HL +T W Sbjct: 2127 KCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAW 2185 Query: 1078 PDHGC---PEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILS 1134 PDH P+D+ F+SY+ I +R PI+ HCSAG+GR+G LI Sbjct: 2186 PDHDTPSQPDDLLTFISYMRHI---------------HRSGPIITHCSAGIGRSGTLICI 2230 Query: 1135 ELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181 ++++ + + ++ ++R +R QR M+QT QY F YQV++ L Sbjct: 2231 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2277 Score = 101 bits (251), Expect = 5e-21 Identities = 87/334 (26%), Positives = 147/334 (44%), Gaps = 35/334 (10%) Query: 25 IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGL-------WF-------LSKS 70 I LL+ +E T ++ ++ + V + L E H F L +F L+K Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKV 635 Query: 71 QQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGR 130 W E K K F LFF + F++ +VS +Q T +QYYLQ++KD+LE R Sbjct: 636 APEGWKEEPKKKTKATVNFT----LFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEER 691 Query: 131 LRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQE- 189 + C + + LA LA+QA++GDY Q + F M+ L V+E+L +E Sbjct: 692 MHCDDETSLLLASLALQAEYGDY-----QPEVHGVSYFRMEHYLPARVMEKLDLSYIKEE 746 Query: 190 ----HKAHSGILPAEAELMYINEVERLDGFG---QEIFPVKDNHGNCVHLGIFFMGIF-- 240 H + G E EL ++ +RL +G + P K + + LG+ G+ Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTG-ILLGVCSKGVLVF 805 Query: 241 -VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRH 299 V N + + + W + I+ +K I ++ + F TD+ + +Y+ L + +H Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQH 865 Query: 300 KFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQ 333 KF Q + ++ WS S P ++ Sbjct: 866 KFQLQMRARQSNQDAQDIDVLHKRWSIVSSPERE 899 >gi|18375646 protein tyrosine phosphatase, non-receptor type 13 isoform 1 [Homo sapiens] Length = 2485 Score = 171 bits (433), Expect = 4e-42 Identities = 98/287 (34%), Positives = 153/287 (53%), Gaps = 23/287 (8%) Query: 898 RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957 R L+ L++G+ E E + + K EN ++R + ++PY+ RV L Sbjct: 2202 RVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPL----G 2257 Query: 958 NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 + GYINAS IK+ VG E+ YIA QGPLP T DFWQM+WEQ VIAM+T E EG + Sbjct: 2258 DEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKI 2317 Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077 K RYWP + K ++ + ++ + + ++ + + + R + HL +T W Sbjct: 2318 KCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAW 2376 Query: 1078 PDHGC---PEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILS 1134 PDH P+D+ F+SY+ I +R PI+ HCSAG+GR+G LI Sbjct: 2377 PDHDTPSQPDDLLTFISYMRHI---------------HRSGPIITHCSAGIGRSGTLICI 2421 Query: 1135 ELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181 ++++ + + ++ ++R +R QR M+QT QY F YQV++ L Sbjct: 2422 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2468 Score = 100 bits (249), Expect = 8e-21 Identities = 86/314 (27%), Positives = 142/314 (45%), Gaps = 37/314 (11%) Query: 25 IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGL-------WF-------LSKS 70 I LL+ +E T ++ ++ + V + L E H F L +F L+K Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKV 635 Query: 71 QQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGR 130 W E K K F LFF + F++ +VS +Q T +QYYLQ++KD+LE R Sbjct: 636 APEGWKEEPKKKTKATVNFT----LFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEER 691 Query: 131 LRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQE- 189 + C + + LA LA+QA++GDY Q + F M+ L V+E+L +E Sbjct: 692 MHCDDETSLLLASLALQAEYGDY-----QPEVHGVSYFRMEHYLPARVMEKLDLSYIKEE 746 Query: 190 ----HKAHSGILPAEAELMYINEVERLDGFG---QEIFPVKDNHGNCVHLGIFFMGIF-- 240 H + G E EL ++ +RL +G + P K + + LG+ G+ Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTG-ILLGVCSKGVLVF 805 Query: 241 -VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRH 299 V N + + + W + I+ +K I ++ + F TD+ + +Y+ L + +H Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQH 865 Query: 300 KFYKQNKICTEQSN 313 KF Q + QSN Sbjct: 866 KFQLQMR--ARQSN 877 >gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform 2 [Homo sapiens] Length = 2466 Score = 171 bits (433), Expect = 4e-42 Identities = 98/287 (34%), Positives = 153/287 (53%), Gaps = 23/287 (8%) Query: 898 RTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE 957 R L+ L++G+ E E + + K EN ++R + ++PY+ RV L Sbjct: 2183 RVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPL----G 2238 Query: 958 NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017 + GYINAS IK+ VG E+ YIA QGPLP T DFWQM+WEQ VIAM+T E EG + Sbjct: 2239 DEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKI 2298 Query: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077 K RYWP + K ++ + ++ + + ++ + + + R + HL +T W Sbjct: 2299 KCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAW 2357 Query: 1078 PDHGC---PEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILS 1134 PDH P+D+ F+SY+ I +R PI+ HCSAG+GR+G LI Sbjct: 2358 PDHDTPSQPDDLLTFISYMRHI---------------HRSGPIITHCSAGIGRSGTLICI 2402 Query: 1135 ELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181 ++++ + + ++ ++R +R QR M+QT QY F YQV++ L Sbjct: 2403 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2449 Score = 100 bits (249), Expect = 8e-21 Identities = 86/314 (27%), Positives = 142/314 (45%), Gaps = 37/314 (11%) Query: 25 IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGL-------WF-------LSKS 70 I LL+ +E T ++ ++ + V + L E H F L +F L+K Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKV 635 Query: 71 QQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGR 130 W E K K F LFF + F++ +VS +Q T +QYYLQ++KD+LE R Sbjct: 636 APEGWKEEPKKKTKATVNFT----LFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEER 691 Query: 131 LRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQE- 189 + C + + LA LA+QA++GDY Q + F M+ L V+E+L +E Sbjct: 692 MHCDDETSLLLASLALQAEYGDY-----QPEVHGVSYFRMEHYLPARVMEKLDLSYIKEE 746 Query: 190 ----HKAHSGILPAEAELMYINEVERLDGFG---QEIFPVKDNHGNCVHLGIFFMGIF-- 240 H + G E EL ++ +RL +G + P K + + LG+ G+ Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTG-ILLGVCSKGVLVF 805 Query: 241 -VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRH 299 V N + + + W + I+ +K I ++ + F TD+ + +Y+ L + +H Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQH 865 Query: 300 KFYKQNKICTEQSN 313 KF Q + QSN Sbjct: 866 KFQLQMR--ARQSN 877 >gi|104487611 protein tyrosine phosphatase, receptor type, sigma isoform 4 precursor [Homo sapiens] Length = 1505 Score = 170 bits (430), Expect = 8e-42 Identities = 113/356 (31%), Positives = 177/356 (49%), Gaps = 22/356 (6%) Query: 834 FSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPM 893 F + D+++ER + ++ L +R M+ + S + E T VP Sbjct: 1156 FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPA 1215 Query: 894 DERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIREVVPYE 946 + ++K ++E G T E++++ KA+ F +A LP N ++R+ ++PYE Sbjct: 1216 RSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE 1275 Query: 947 ENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVI 1005 RV L P + + YINAS I + YIATQGPL T DFW+M+WE ++ Sbjct: 1276 STRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1333 Query: 1006 AMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQ 1065 M+T E GR K H+YWP SA Y F V + Y KV GQ Sbjct: 1334 VMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1389 Query: 1066 ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGV 1125 RTV Q+TDWP+ G P+ +GF+ ++ ++ + + PI VHCSAGV Sbjct: 1390 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVHCSAGV 1441 Query: 1126 GRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181 GRTGV I +++ + + V++ +++LR QR M+QT +Y+F YQ +++L Sbjct: 1442 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1497 Score = 153 bits (387), Expect = 8e-37 Identities = 91/251 (36%), Positives = 135/251 (53%), Gaps = 17/251 (6%) Query: 930 LPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPH 988 L N ++R V+ Y+ +RV L P + + YINA+++ + YIATQGPLP Sbjct: 970 LEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGY--RCQNAYIATQGPLPE 1027 Query: 989 TCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDS 1048 T DFW+MVWEQ I M+T EE R K +YWP G++ TYG +VT + Sbjct: 1028 TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE----TYGFIQVTLLDTIEL 1083 Query: 1049 VCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLE 1108 + + S ++R V Q+T WPDHG PE FL++L +++ Sbjct: 1084 ATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG--- 1140 Query: 1109 GTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIA 1168 PIVVHCSAGVGRTG I+ + M+ ++ + V+V + L+R QR +M+QT Sbjct: 1141 -------PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1193 Query: 1169 QYKFVYQVLIQ 1179 QY F+++ L++ Sbjct: 1194 QYSFIHEALLE 1204 >gi|104487297 protein tyrosine phosphatase, receptor type, sigma isoform 2 precursor [Homo sapiens] Length = 1910 Score = 170 bits (430), Expect = 8e-42 Identities = 113/356 (31%), Positives = 177/356 (49%), Gaps = 22/356 (6%) Query: 834 FSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPM 893 F + D+++ER + ++ L +R M+ + S + E T VP Sbjct: 1561 FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPA 1620 Query: 894 DERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIREVVPYE 946 + ++K ++E G T E++++ KA+ F +A LP N ++R+ ++PYE Sbjct: 1621 RSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE 1680 Query: 947 ENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVI 1005 RV L P + + YINAS I + YIATQGPL T DFW+M+WE ++ Sbjct: 1681 STRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1738 Query: 1006 AMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQ 1065 M+T E GR K H+YWP SA Y F V + Y KV GQ Sbjct: 1739 VMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1794 Query: 1066 ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGV 1125 RTV Q+TDWP+ G P+ +GF+ ++ ++ + + PI VHCSAGV Sbjct: 1795 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVHCSAGV 1846 Query: 1126 GRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181 GRTGV I +++ + + V++ +++LR QR M+QT +Y+F YQ +++L Sbjct: 1847 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1902 Score = 153 bits (387), Expect = 8e-37 Identities = 91/251 (36%), Positives = 135/251 (53%), Gaps = 17/251 (6%) Query: 930 LPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPH 988 L N ++R V+ Y+ +RV L P + + YINA+++ + YIATQGPLP Sbjct: 1375 LEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGY--RCQNAYIATQGPLPE 1432 Query: 989 TCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDS 1048 T DFW+MVWEQ I M+T EE R K +YWP G++ TYG +VT + Sbjct: 1433 TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE----TYGFIQVTLLDTIEL 1488 Query: 1049 VCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLE 1108 + + S ++R V Q+T WPDHG PE FL++L +++ Sbjct: 1489 ATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG--- 1545 Query: 1109 GTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIA 1168 PIVVHCSAGVGRTG I+ + M+ ++ + V+V + L+R QR +M+QT Sbjct: 1546 -------PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1598 Query: 1169 QYKFVYQVLIQ 1179 QY F+++ L++ Sbjct: 1599 QYSFIHEALLE 1609 >gi|104487295 protein tyrosine phosphatase, receptor type, sigma isoform 3 precursor [Homo sapiens] Length = 1501 Score = 170 bits (430), Expect = 8e-42 Identities = 113/356 (31%), Positives = 177/356 (49%), Gaps = 22/356 (6%) Query: 834 FSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPM 893 F + D+++ER + ++ L +R M+ + S + E T VP Sbjct: 1152 FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPA 1211 Query: 894 DERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIREVVPYE 946 + ++K ++E G T E++++ KA+ F +A LP N ++R+ ++PYE Sbjct: 1212 RSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE 1271 Query: 947 ENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVI 1005 RV L P + + YINAS I + YIATQGPL T DFW+M+WE ++ Sbjct: 1272 STRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1329 Query: 1006 AMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQ 1065 M+T E GR K H+YWP SA Y F V + Y KV GQ Sbjct: 1330 VMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1385 Query: 1066 ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGV 1125 RTV Q+TDWP+ G P+ +GF+ ++ ++ + + PI VHCSAGV Sbjct: 1386 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVHCSAGV 1437 Query: 1126 GRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181 GRTGV I +++ + + V++ +++LR QR M+QT +Y+F YQ +++L Sbjct: 1438 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1493 Score = 153 bits (387), Expect = 8e-37 Identities = 91/251 (36%), Positives = 135/251 (53%), Gaps = 17/251 (6%) Query: 930 LPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPH 988 L N ++R V+ Y+ +RV L P + + YINA+++ + YIATQGPLP Sbjct: 966 LEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGY--RCQNAYIATQGPLPE 1023 Query: 989 TCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDS 1048 T DFW+MVWEQ I M+T EE R K +YWP G++ TYG +VT + Sbjct: 1024 TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE----TYGFIQVTLLDTIEL 1079 Query: 1049 VCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLE 1108 + + S ++R V Q+T WPDHG PE FL++L +++ Sbjct: 1080 ATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG--- 1136 Query: 1109 GTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIA 1168 PIVVHCSAGVGRTG I+ + M+ ++ + V+V + L+R QR +M+QT Sbjct: 1137 -------PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1189 Query: 1169 QYKFVYQVLIQ 1179 QY F+++ L++ Sbjct: 1190 QYSFIHEALLE 1200 >gi|104487006 protein tyrosine phosphatase, receptor type, sigma isoform 1 precursor [Homo sapiens] Length = 1948 Score = 170 bits (430), Expect = 8e-42 Identities = 113/356 (31%), Positives = 177/356 (49%), Gaps = 22/356 (6%) Query: 834 FSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPM 893 F + D+++ER + ++ L +R M+ + S + E T VP Sbjct: 1599 FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPA 1658 Query: 894 DERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIREVVPYE 946 + ++K ++E G T E++++ KA+ F +A LP N ++R+ ++PYE Sbjct: 1659 RSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE 1718 Query: 947 ENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVI 1005 RV L P + + YINAS I + YIATQGPL T DFW+M+WE ++ Sbjct: 1719 STRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1776 Query: 1006 AMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQ 1065 M+T E GR K H+YWP SA Y F V + Y KV GQ Sbjct: 1777 VMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1832 Query: 1066 ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGV 1125 RTV Q+TDWP+ G P+ +GF+ ++ ++ + + PI VHCSAGV Sbjct: 1833 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVHCSAGV 1884 Query: 1126 GRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL 1181 GRTGV I +++ + + V++ +++LR QR M+QT +Y+F YQ +++L Sbjct: 1885 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1940 Score = 153 bits (387), Expect = 8e-37 Identities = 91/251 (36%), Positives = 135/251 (53%), Gaps = 17/251 (6%) Query: 930 LPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPH 988 L N ++R V+ Y+ +RV L P + + YINA+++ + YIATQGPLP Sbjct: 1413 LEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGY--RCQNAYIATQGPLPE 1470 Query: 989 TCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDS 1048 T DFW+MVWEQ I M+T EE R K +YWP G++ TYG +VT + Sbjct: 1471 TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE----TYGFIQVTLLDTIEL 1526 Query: 1049 VCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLE 1108 + + S ++R V Q+T WPDHG PE FL++L +++ Sbjct: 1527 ATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG--- 1583 Query: 1109 GTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIA 1168 PIVVHCSAGVGRTG I+ + M+ ++ + V+V + L+R QR +M+QT Sbjct: 1584 -------PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1636 Query: 1169 QYKFVYQVLIQ 1179 QY F+++ L++ Sbjct: 1637 QYSFIHEALLE 1647 >gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5 precursor [Homo sapiens] Length = 1502 Score = 168 bits (426), Expect = 2e-41 Identities = 104/301 (34%), Positives = 157/301 (52%), Gaps = 22/301 (7%) Query: 889 TRVPMDERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIRE 941 T VP + ++K ++E G T E++++ KA+ F +A LP N ++R+ Sbjct: 1208 TEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVN 1267 Query: 942 VVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQ 1000 ++PYE RV L P + + YINAS I + YIATQGPL T DFW+M+WE Sbjct: 1268 IMPYESTRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEH 1325 Query: 1001 GVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKH 1060 ++ M+T E GR K H+YWP SA Y F V + Y KV Sbjct: 1326 NSTIVVMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTD 1381 Query: 1061 LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVH 1120 GQ RTV Q+TDWP+ G P+ +GF+ ++ ++ + + PI VH Sbjct: 1382 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVH 1433 Query: 1121 CSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF 1180 CSAGVGRTGV I +++ + + V++ +++LR QR M+QT QY+F Y+ +++ Sbjct: 1434 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1493 Query: 1181 L 1181 L Sbjct: 1494 L 1494 Score = 148 bits (373), Expect = 3e-35 Identities = 94/280 (33%), Positives = 146/280 (52%), Gaps = 21/280 (7%) Query: 903 KLEEGMVFT-EYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTG 961 K + + F+ EYE I + + + L N ++R V+ Y+ +RV L+ E G Sbjct: 940 KANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPG 997 Query: 962 --YINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKS 1019 Y+NA++I + YIATQG LP T DFW+M+WEQ + M+T EE R K Sbjct: 998 SDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKC 1055 Query: 1020 HRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPD 1079 +YWP G++ T+G +VT + Y + S ++R V Q+T WPD Sbjct: 1056 DQYWPSRGTE----THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPD 1111 Query: 1080 HGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIY 1139 HG PE FL++L +++ P+VVHCSAGVGRTG I+ + M+ Sbjct: 1112 HGVPEHPTPFLAFLRRVKTCNPPDAG----------PMVVHCSAGVGRTGCFIVIDAMLE 1161 Query: 1140 CLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179 ++H + V++ + L+R QR +M+QT QY F++ L++ Sbjct: 1162 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE 1201 >gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1 precursor [Homo sapiens] Length = 1912 Score = 168 bits (426), Expect = 2e-41 Identities = 104/301 (34%), Positives = 157/301 (52%), Gaps = 22/301 (7%) Query: 889 TRVPMDERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIRE 941 T VP + ++K ++E G T E++++ KA+ F +A LP N ++R+ Sbjct: 1618 TEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVN 1677 Query: 942 VVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQ 1000 ++PYE RV L P + + YINAS I + YIATQGPL T DFW+M+WE Sbjct: 1678 IMPYESTRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEH 1735 Query: 1001 GVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKH 1060 ++ M+T E GR K H+YWP SA Y F V + Y KV Sbjct: 1736 NSTIVVMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTD 1791 Query: 1061 LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVH 1120 GQ RTV Q+TDWP+ G P+ +GF+ ++ ++ + + PI VH Sbjct: 1792 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVH 1843 Query: 1121 CSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF 1180 CSAGVGRTGV I +++ + + V++ +++LR QR M+QT QY+F Y+ +++ Sbjct: 1844 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1903 Query: 1181 L 1181 L Sbjct: 1904 L 1904 Score = 148 bits (373), Expect = 3e-35 Identities = 94/280 (33%), Positives = 146/280 (52%), Gaps = 21/280 (7%) Query: 903 KLEEGMVFT-EYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTG 961 K + + F+ EYE I + + + L N ++R V+ Y+ +RV L+ E G Sbjct: 1350 KANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPG 1407 Query: 962 --YINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKS 1019 Y+NA++I + YIATQG LP T DFW+M+WEQ + M+T EE R K Sbjct: 1408 SDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKC 1465 Query: 1020 HRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPD 1079 +YWP G++ T+G +VT + Y + S ++R V Q+T WPD Sbjct: 1466 DQYWPSRGTE----THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPD 1521 Query: 1080 HGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIY 1139 HG PE FL++L +++ P+VVHCSAGVGRTG I+ + M+ Sbjct: 1522 HGVPEHPTPFLAFLRRVKTCNPPDAG----------PMVVHCSAGVGRTGCFIVIDAMLE 1571 Query: 1140 CLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179 ++H + V++ + L+R QR +M+QT QY F++ L++ Sbjct: 1572 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE 1611 >gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2 precursor [Homo sapiens] Length = 1899 Score = 168 bits (426), Expect = 2e-41 Identities = 104/301 (34%), Positives = 157/301 (52%), Gaps = 22/301 (7%) Query: 889 TRVPMDERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIRE 941 T VP + ++K ++E G T E++++ KA+ F +A LP N ++R+ Sbjct: 1605 TEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVN 1664 Query: 942 VVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQ 1000 ++PYE RV L P + + YINAS I + YIATQGPL T DFW+M+WE Sbjct: 1665 IMPYESTRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEH 1722 Query: 1001 GVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKH 1060 ++ M+T E GR K H+YWP SA Y F V + Y KV Sbjct: 1723 NSTIVVMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTD 1778 Query: 1061 LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVH 1120 GQ RTV Q+TDWP+ G P+ +GF+ ++ ++ + + PI VH Sbjct: 1779 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVH 1830 Query: 1121 CSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF 1180 CSAGVGRTGV I +++ + + V++ +++LR QR M+QT QY+F Y+ +++ Sbjct: 1831 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1890 Query: 1181 L 1181 L Sbjct: 1891 L 1891 Score = 148 bits (373), Expect = 3e-35 Identities = 94/280 (33%), Positives = 146/280 (52%), Gaps = 21/280 (7%) Query: 903 KLEEGMVFT-EYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTG 961 K + + F+ EYE I + + + L N ++R V+ Y+ +RV L+ E G Sbjct: 1337 KANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPG 1394 Query: 962 --YINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKS 1019 Y+NA++I + YIATQG LP T DFW+M+WEQ + M+T EE R K Sbjct: 1395 SDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKC 1452 Query: 1020 HRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPD 1079 +YWP G++ T+G +VT + Y + S ++R V Q+T WPD Sbjct: 1453 DQYWPSRGTE----THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPD 1508 Query: 1080 HGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIY 1139 HG PE FL++L +++ P+VVHCSAGVGRTG I+ + M+ Sbjct: 1509 HGVPEHPTPFLAFLRRVKTCNPPDAG----------PMVVHCSAGVGRTGCFIVIDAMLE 1558 Query: 1140 CLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179 ++H + V++ + L+R QR +M+QT QY F++ L++ Sbjct: 1559 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE 1598 >gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3 precursor [Homo sapiens] Length = 1903 Score = 168 bits (426), Expect = 2e-41 Identities = 104/301 (34%), Positives = 157/301 (52%), Gaps = 22/301 (7%) Query: 889 TRVPMDERFRTLKK--KLEEGMVFT----EYEQIPKKKAN-GIFSTAALPENAERSRIRE 941 T VP + ++K ++E G T E++++ KA+ F +A LP N ++R+ Sbjct: 1609 TEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVN 1668 Query: 942 VVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQ 1000 ++PYE RV L P + + YINAS I + YIATQGPL T DFW+M+WE Sbjct: 1669 IMPYESTRVCLQPIRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEH 1726 Query: 1001 GVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKH 1060 ++ M+T E GR K H+YWP SA Y F V + Y KV Sbjct: 1727 NSTIVVMLTKLREMGREKCHQYWP----AERSARYQYFVVDPMAEYNMPQYILREFKVTD 1782 Query: 1061 LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVH 1120 GQ RTV Q+TDWP+ G P+ +GF+ ++ ++ + + PI VH Sbjct: 1783 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF--------GQDGPISVH 1834 Query: 1121 CSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF 1180 CSAGVGRTGV I +++ + + V++ +++LR QR M+QT QY+F Y+ +++ Sbjct: 1835 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1894 Query: 1181 L 1181 L Sbjct: 1895 L 1895 Score = 148 bits (373), Expect = 3e-35 Identities = 94/280 (33%), Positives = 146/280 (52%), Gaps = 21/280 (7%) Query: 903 KLEEGMVFT-EYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTG 961 K + + F+ EYE I + + + L N ++R V+ Y+ +RV L+ E G Sbjct: 1341 KANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPG 1398 Query: 962 --YINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKS 1019 Y+NA++I + YIATQG LP T DFW+M+WEQ + M+T EE R K Sbjct: 1399 SDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKC 1456 Query: 1020 HRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPD 1079 +YWP G++ T+G +VT + Y + S ++R V Q+T WPD Sbjct: 1457 DQYWPSRGTE----THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPD 1512 Query: 1080 HGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIY 1139 HG PE FL++L +++ P+VVHCSAGVGRTG I+ + M+ Sbjct: 1513 HGVPEHPTPFLAFLRRVKTCNPPDAG----------PMVVHCSAGVGRTGCFIVIDAMLE 1562 Query: 1140 CLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179 ++H + V++ + L+R QR +M+QT QY F++ L++ Sbjct: 1563 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE 1602 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.132 0.389 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 48,464,308 Number of Sequences: 37866 Number of extensions: 2404830 Number of successful extensions: 12554 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 152 Number of HSP's successfully gapped in prelim test: 144 Number of HSP's that attempted gapping in prelim test: 11455 Number of HSP's gapped (non-prelim): 797 length of query: 1187 length of database: 18,247,518 effective HSP length: 113 effective length of query: 1074 effective length of database: 13,968,660 effective search space: 15002340840 effective search space used: 15002340840 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.