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Search of human proteins with 34304336
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34304336 ring finger protein 8 isoform 2 [Homo sapiens]
(448 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34304336 ring finger protein 8 isoform 2 [Homo sapiens] 900 0.0
gi|4504867 ring finger protein 8 isoform 1 [Homo sapiens] 829 0.0
gi|221139761 zinc finger protein 853 [Homo sapiens] 60 5e-09
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 56 8e-08
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 55 1e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 55 1e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 55 1e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 55 1e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 55 1e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 55 1e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 55 1e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 55 1e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 55 1e-07
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 54 3e-07
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 53 5e-07
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 53 6e-07
gi|148746195 trichohyalin [Homo sapiens] 52 1e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 51 2e-06
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 51 2e-06
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 51 2e-06
gi|42794779 myosin 18A isoform b [Homo sapiens] 50 3e-06
gi|28416946 myosin 18A isoform a [Homo sapiens] 50 3e-06
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 49 7e-06
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 49 7e-06
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 49 7e-06
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 49 7e-06
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 49 7e-06
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 49 7e-06
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 49 9e-06
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 49 9e-06
>gi|34304336 ring finger protein 8 isoform 2 [Homo sapiens]
Length = 448
Score = 900 bits (2327), Expect = 0.0
Identities = 448/448 (100%), Positives = 448/448 (100%)
Query: 1 MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS 60
MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS
Sbjct: 1 MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS 60
Query: 61 RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY 120
RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY
Sbjct: 61 RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY 120
Query: 121 EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS 180
EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS
Sbjct: 121 EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS 180
Query: 181 CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS 240
CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS
Sbjct: 181 CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS 240
Query: 241 ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC 300
ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC
Sbjct: 241 ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC 300
Query: 301 AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD 360
AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD
Sbjct: 301 AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD 360
Query: 361 FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDCSEDR 420
FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDCSEDR
Sbjct: 361 FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDCSEDR 420
Query: 421 ALRAFERLPGSASLRWSGGFSLAVTPLL 448
ALRAFERLPGSASLRWSGGFSLAVTPLL
Sbjct: 421 ALRAFERLPGSASLRWSGGFSLAVTPLL 448
>gi|4504867 ring finger protein 8 isoform 1 [Homo sapiens]
Length = 485
Score = 829 bits (2142), Expect = 0.0
Identities = 412/412 (100%), Positives = 412/412 (100%)
Query: 1 MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS 60
MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS
Sbjct: 1 MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS 60
Query: 61 RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY 120
RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY
Sbjct: 61 RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY 120
Query: 121 EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS 180
EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS
Sbjct: 121 EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS 180
Query: 181 CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS 240
CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS
Sbjct: 181 CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS 240
Query: 241 ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC 300
ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC
Sbjct: 241 ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC 300
Query: 301 AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD 360
AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD
Sbjct: 301 AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD 360
Query: 361 FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIE 412
FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIE
Sbjct: 361 FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIE 412
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 59.7 bits (143), Expect = 5e-09
Identities = 43/203 (21%), Positives = 102/203 (50%), Gaps = 9/203 (4%)
Query: 194 EVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSAS--------QRS 245
E+ P + +L+ L+ K P++ +H +Q+ Q
Sbjct: 117 ELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQ 176
Query: 246 LQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQ 305
LQ + ++L+ + Q+Q++ + +++Q ++ ++++Q +++LQ Q Q EQ Q
Sbjct: 177 LQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQ 236
Query: 306 QQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAII 365
QQ ++ L++ Q ++Q LQ + ++ L+QQ AQ LQ+ L ++ ++ + ++
Sbjct: 237 QQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQ-LQQQLLLQQQEQLQQQQQQQLL 295
Query: 366 QAKNKELEQTKEEKEKMQAQKEE 388
Q + ++L+Q + + ++ ++EE
Sbjct: 296 QQQQEQLQQQQLQPPPLEPEEEE 318
Score = 46.6 bits (109), Expect = 5e-05
Identities = 34/164 (20%), Positives = 81/164 (49%), Gaps = 7/164 (4%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVV-Q 287
++ +Q Q+ Q+ + L+ ++ Q++ + + +Q Q ++++ Q
Sbjct: 222 QLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQ 281
Query: 288 MEQELQDLQSQLCAEQAQQQARVEQLE----KTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+++LQ Q Q +Q Q+Q + +QL+ + +EEE L+ + + G + +Q Q
Sbjct: 282 QQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQE 341
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
L+ L E + ++ + +Q + ++LEQ E++++ Q+E
Sbjct: 342 LERQQEL--ERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQE 383
Score = 42.7 bits (99), Expect = 7e-04
Identities = 34/165 (20%), Positives = 80/165 (48%), Gaps = 27/165 (16%)
Query: 264 QEKHEAV--MNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQL-------- 313
QEKH++V +K + Q + ++ +Q +Q +Q Q +Q Q+Q + +Q
Sbjct: 135 QEKHQSVHHQELKPELQLMHQQQQLQPQQ----VQEQQRLQQQQEQLQTQQAQEQQVLQQ 190
Query: 314 ----------EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEE---LNRSKKD 360
++ Q++++ LQ ++ Q ++ L+QQ Q QE ++ L + +
Sbjct: 191 QEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQL 250
Query: 361 FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCII 405
+ ++Q + +L+Q E+++ Q Q++ +L + + + Q ++
Sbjct: 251 QQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLL 295
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/195 (22%), Positives = 95/195 (48%), Gaps = 31/195 (15%)
Query: 211 EPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAV 270
EP + +P P V + A + QR LQ+ ++ + Q Q +HE +
Sbjct: 56 EPQERNSSPQRPAVS--APVGASEIAEETRPGQRELQLQQLEQQP----EPQQQPQHEQL 109
Query: 271 ------MNVKKQTQKGNSKKVVQMEQEL------QDLQSQLCAEQAQQQARVEQLEKT-- 316
+ +++Q Q+ +++ Q++QE Q+L+ +L QQQ + +Q+++
Sbjct: 110 QQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQR 169
Query: 317 FQEEEQHLQGLEIAQGEKDLKQQ--LAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQ 374
Q++++ LQ + AQ ++ L+QQ L Q +QE L ++ + +Q + +Q
Sbjct: 170 LQQQQEQLQTQQ-AQEQQVLQQQEQLQQQVQEQQLLQQQQEQ--------LQQQQLLQQQ 220
Query: 375 TKEEKEKMQAQKEEV 389
+ ++++ Q Q+E++
Sbjct: 221 EQLQQQQFQQQQEQL 235
Score = 41.2 bits (95), Expect = 0.002
Identities = 38/144 (26%), Positives = 71/144 (49%), Gaps = 10/144 (6%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQA--QQQARVEQLEKTFQE 319
Q QE+ + + Q+G ++ + +Q+ Q Q L +QA QQQ ++Q E+ Q+
Sbjct: 230 QQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQ 289
Query: 320 EEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEK 379
++Q L + Q ++ L+Q Q LQ EE + + + +ELEQ ++E
Sbjct: 290 QQQQL----LQQQQEQLQQ---QQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQEL 342
Query: 380 EKMQ-AQKEEVLSHMNDVLENELQ 402
E+ Q ++++ + L+ ELQ
Sbjct: 343 ERQQELERQQEQRQLQLKLQEELQ 366
Score = 34.3 bits (77), Expect = 0.24
Identities = 41/162 (25%), Positives = 74/162 (45%), Gaps = 27/162 (16%)
Query: 243 QRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQE-LQDLQSQ--- 298
Q+ LQ + + + L + Q Q + + ++ ++Q Q+ ++++Q +QE LQ Q Q
Sbjct: 252 QQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPP 311
Query: 299 -----------------LCAEQAQQQARVE---QLEKTFQEEEQHLQGLEIAQGEKDLKQ 338
L +EQ +Q R E Q E Q+E++ LQ L++ + + L+Q
Sbjct: 312 LEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQ-LKLQEELQQLEQ 370
Query: 339 QLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKE 380
QL Q Q+ +E+ E Q + +LE T + E
Sbjct: 371 QLEQ--QQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPE 410
Score = 33.1 bits (74), Expect = 0.52
Identities = 23/83 (27%), Positives = 46/83 (55%), Gaps = 4/83 (4%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQE---E 320
Q++ E + + Q+ + +++++ELQ L+ QL +Q Q + + QLE T E +
Sbjct: 337 QQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQ 396
Query: 321 EQHLQGLEIAQGEKDLKQQLAQA 343
+Q +Q LE+ + +L+ +L A
Sbjct: 397 QQEVQ-LELTPVQPELQLELVPA 418
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 55.8 bits (133), Expect = 8e-08
Identities = 56/258 (21%), Positives = 119/258 (46%), Gaps = 24/258 (9%)
Query: 137 SPKNDQMIEKNKEL--RTKRKFSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGE 194
SPK + ++ + + K DE++ + + + KV G P +Q +G
Sbjct: 344 SPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKG-PSFNQERGT 402
Query: 195 VASTPSDNLDPKLTALE--PSKTTGAPIYPG-FPKVTEVHHEQKASNSSASQRSLQMFKV 251
+ P PKL A + P P PG FP +V E + Q+S V
Sbjct: 403 SSHLPPP---PKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAV 459
Query: 252 TMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVE 311
+R + + E +++Q + ++K+ +++++L L+ Q E+ +++ R +
Sbjct: 460 ERAR--------KRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREK 511
Query: 312 QLEKTFQ-EEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
+ E+ + E+EQ + + + +++ +Q+ + L++ E+ + +K Q K K
Sbjct: 512 EREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERK------QEKEK 565
Query: 371 ELEQTKEEKEKMQAQKEE 388
ELE+ KE+++++Q KE+
Sbjct: 566 ELERQKEKEKELQKMKEQ 583
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 55.1 bits (131), Expect = 1e-07
Identities = 40/180 (22%), Positives = 89/180 (49%), Gaps = 14/180 (7%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQEL 292
EQ Q+ + ++ + + QM E+ E V ++Q QK +++ + E+++
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQK-QEEQMRKQEEQM 264
Query: 293 QDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALME 352
++ + Q+ + Q++ ++Q E+T QEE+ Q ++ + E+ +++Q Q ++ + E
Sbjct: 265 REQEEQM---REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMRE 321
Query: 353 ELNRSKKDFEAIIQAKN----------KELEQTKEEKEKMQAQKEEVLSHMNDVLENELQ 402
+ + K E + + K K+ EQ E++E+MQ Q+E+V + + E Q
Sbjct: 322 QEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQ 381
Score = 53.1 bits (126), Expect = 5e-07
Identities = 38/154 (24%), Positives = 85/154 (55%), Gaps = 8/154 (5%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE 321
QM E+ E + ++Q QK +++ + E++++ + Q+ ++ Q Q + EQ++K QEE+
Sbjct: 200 QMGEQEEQMGEQEEQMQK-QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQK--QEEQ 256
Query: 322 QHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEK 381
Q ++ + E+ +++Q Q L++ E+ + ++ E Q + +E EQ +E++E+
Sbjct: 257 MRKQEEQMREQEEQMREQEEQMLKQK----EQTEQEEQTGEQEEQMREQE-EQMREQEEQ 311
Query: 382 MQAQKEEVLSHMNDVLENELQCIICSEYFIEQRD 415
M+ Q+E++ + + E Q E EQ++
Sbjct: 312 MREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKE 345
Score = 53.1 bits (126), Expect = 5e-07
Identities = 35/183 (19%), Positives = 92/183 (50%), Gaps = 8/183 (4%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQEL 292
EQ Q+ + + ++ + QM+E+ E ++ K+QT++ ++ + E+++
Sbjct: 241 EQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ--EEQTGEQEEQM 298
Query: 293 QDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALME 352
++ + Q+ ++ Q + + EQ+ +E+E+ + E E+ K+Q+ + ++ W E
Sbjct: 299 REQEEQMREQEEQMREQEEQM----REQEEQMGKQEEQMWEQ--KEQMWEQKEQMWKQEE 352
Query: 353 ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIE 412
++ ++ + + K+ EQ ++++E+M+ Q+E++ + E + Q E E
Sbjct: 353 QMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMRE 412
Query: 413 QRD 415
Q +
Sbjct: 413 QEE 415
Score = 43.5 bits (101), Expect = 4e-04
Identities = 31/148 (20%), Positives = 78/148 (52%), Gaps = 8/148 (5%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQL-----EKT 316
Q++E+ V + Q ++ + + + E ++ + + Q+ ++ Q Q + EQ+ +
Sbjct: 172 QVREQEGQVREQEGQVREQEGQ-MGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR 230
Query: 317 FQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAK--NKELEQ 374
QEE+ Q ++ + E+ +++Q Q ++ + E+ + ++ E +++ K ++ EQ
Sbjct: 231 KQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQ 290
Query: 375 TKEEKEKMQAQKEEVLSHMNDVLENELQ 402
T E++E+M+ Q+E++ + E E Q
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQ 318
Score = 40.8 bits (94), Expect = 0.003
Identities = 30/148 (20%), Positives = 76/148 (51%), Gaps = 7/148 (4%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQ--DLQSQLCAEQAQ---QQARVEQ 312
+++ Q + E V++Q + ++ EQE Q + + Q+ ++ Q Q+ ++ +
Sbjct: 144 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGE 203
Query: 313 LEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKEL 372
E+ E+E+ +Q E GE++ +Q+ + ++ E++ + ++ + + K+
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQE--EQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQE 261
Query: 373 EQTKEEKEKMQAQKEEVLSHMNDVLENE 400
EQ +E++E+M+ Q+E++L + E
Sbjct: 262 EQMREQEEQMREQEEQMLKQKEQTEQEE 289
Score = 40.0 bits (92), Expect = 0.004
Identities = 32/157 (20%), Positives = 80/157 (50%), Gaps = 7/157 (4%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQ---QQARVEQLEKTFQ 318
Q++E+ V + Q ++ + V + E ++++ + Q+ ++ Q Q+ ++ + E+
Sbjct: 151 QVREQEGQVREQEGQVREQEGQ-VREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMG 209
Query: 319 EEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEE 378
E+E+ +Q E GE++ +Q+ + ++ E++ + ++ + + K+ EQ +E+
Sbjct: 210 EQEEQMQKQEEQMGEQE--EQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQ 267
Query: 379 KEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRD 415
+E+M ++EE + + E E Q E EQ +
Sbjct: 268 EEQM-REQEEQMLKQKEQTEQEEQTGEQEEQMREQEE 303
Score = 38.9 bits (89), Expect = 0.010
Identities = 30/160 (18%), Positives = 78/160 (48%), Gaps = 6/160 (3%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQ---QQARVEQLEKTFQ 318
Q++E+ V + Q ++ + V + E ++++ + Q+ ++ Q Q+ +V + E
Sbjct: 137 QVREQEGQVREQEGQVREQEGQ-VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMG 195
Query: 319 EEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEE 378
E+E + E GE++ +Q+ + ++ E++ + ++ + K+ EQ +++
Sbjct: 196 EQEGQMGEQEEQMGEQE--EQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQ 253
Query: 379 KEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDCSE 418
+E+M+ Q+E++ + E E Q + E ++ E
Sbjct: 254 EEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGE 293
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2575 QLEQQRR----QQEELLAEENQRLREQLQLL 2601
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/192 (25%), Positives = 90/192 (46%), Gaps = 23/192 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1312 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1370
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDC 416
A IQAK ++ E + EE+ ++ + E E ELQ + E+ +
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEA 1487
Query: 417 SEDRALRAFERL 428
+ +A ERL
Sbjct: 1488 QKRQAQEEAERL 1499
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/198 (21%), Positives = 86/198 (43%), Gaps = 27/198 (13%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1709 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1748
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCII 405
+ L EL + + + E ++ +K + E+++ EK + + E ++ E +
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1808
Query: 406 CSEYFIEQRDCSEDRALR 423
+E QR +E+ A R
Sbjct: 1809 LAEEAKRQRQLAEEDAAR 1826
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2278 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Score = 40.8 bits (94), Expect = 0.003
Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 50/219 (22%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2413
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2414 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2463
Query: 384 AQ-------KEEVLSHMNDVLENELQCIICSEYFIEQRD 415
+ EE+ + + L E Q + + F+ ++D
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKD 2500
Score = 39.7 bits (91), Expect = 0.006
Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 13/168 (7%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2091 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2146
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQT-------K 376
+ + Q KQ +++H E+ R K E + +LE+T
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 377 EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYF--IEQRDCSEDRAL 422
EE ++++A+ E + V E + E ++ R +E+RAL
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Score = 39.3 bits (90), Expect = 0.007
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1524 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1572
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1631 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1672
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/206 (22%), Positives = 98/206 (47%), Gaps = 34/206 (16%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1769
Query: 407 SEYFIEQRDCSEDRALRAFERLPGSA 432
S+ E+ S + ++ +RL A
Sbjct: 1770 SKARAEEE--SRSTSEKSKQRLEAEA 1793
Score = 38.1 bits (87), Expect = 0.016
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2116
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2172
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Score = 37.7 bits (86), Expect = 0.021
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2569 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2215
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2216 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2267 QEEAEKMKQVAEE 2279
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2521 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2579 QLEQQRR----QQEELLAEENQRLREQLQLL 2605
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/192 (25%), Positives = 90/192 (46%), Gaps = 23/192 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1316 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1374
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1375 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1434
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDC 416
A IQAK ++ E + EE+ ++ + E E ELQ + E+ +
Sbjct: 1435 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEA 1491
Query: 417 SEDRALRAFERL 428
+ +A ERL
Sbjct: 1492 QKRQAQEEAERL 1503
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/198 (21%), Positives = 86/198 (43%), Gaps = 27/198 (13%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1713 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1752
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCII 405
+ L EL + + + E ++ +K + E+++ EK + + E ++ E +
Sbjct: 1753 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1812
Query: 406 CSEYFIEQRDCSEDRALR 423
+E QR +E+ A R
Sbjct: 1813 LAEEAKRQRQLAEEDAAR 1830
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2222 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2281
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2282 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2339
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2340 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2396
Score = 40.8 bits (94), Expect = 0.003
Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 50/219 (22%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2358
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2359 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2417
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2418 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2467
Query: 384 AQ-------KEEVLSHMNDVLENELQCIICSEYFIEQRD 415
+ EE+ + + L E Q + + F+ ++D
Sbjct: 2468 QEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKD 2504
Score = 39.7 bits (91), Expect = 0.006
Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 13/168 (7%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2095 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2150
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQT-------K 376
+ + Q KQ +++H E+ R K E + +LE+T
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 377 EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYF--IEQRDCSEDRAL 422
EE ++++A+ E + V E + E ++ R +E+RAL
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258
Score = 39.3 bits (90), Expect = 0.007
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1528 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1576
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1634
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1635 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1676
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/206 (22%), Positives = 98/206 (47%), Gaps = 34/206 (16%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1654
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1714
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1715 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1773
Query: 407 SEYFIEQRDCSEDRALRAFERLPGSA 432
S+ E+ S + ++ +RL A
Sbjct: 1774 SKARAEEE--SRSTSEKSKQRLEAEA 1797
Score = 38.1 bits (87), Expect = 0.016
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2120
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2176
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2214
Score = 37.7 bits (86), Expect = 0.021
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2456 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2515
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2516 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2573 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2624
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2219
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2220 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2270
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2271 QEEAEKMKQVAEE 2283
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2575 QLEQQRR----QQEELLAEENQRLREQLQLL 2601
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/192 (25%), Positives = 90/192 (46%), Gaps = 23/192 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1312 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1370
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDC 416
A IQAK ++ E + EE+ ++ + E E ELQ + E+ +
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEA 1487
Query: 417 SEDRALRAFERL 428
+ +A ERL
Sbjct: 1488 QKRQAQEEAERL 1499
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/198 (21%), Positives = 86/198 (43%), Gaps = 27/198 (13%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1709 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1748
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCII 405
+ L EL + + + E ++ +K + E+++ EK + + E ++ E +
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1808
Query: 406 CSEYFIEQRDCSEDRALR 423
+E QR +E+ A R
Sbjct: 1809 LAEEAKRQRQLAEEDAAR 1826
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2278 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Score = 40.8 bits (94), Expect = 0.003
Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 50/219 (22%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2413
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2414 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2463
Query: 384 AQ-------KEEVLSHMNDVLENELQCIICSEYFIEQRD 415
+ EE+ + + L E Q + + F+ ++D
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKD 2500
Score = 39.7 bits (91), Expect = 0.006
Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 13/168 (7%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2091 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2146
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQT-------K 376
+ + Q KQ +++H E+ R K E + +LE+T
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 377 EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYF--IEQRDCSEDRAL 422
EE ++++A+ E + V E + E ++ R +E+RAL
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Score = 39.3 bits (90), Expect = 0.007
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1524 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1572
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1631 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1672
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/206 (22%), Positives = 98/206 (47%), Gaps = 34/206 (16%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1769
Query: 407 SEYFIEQRDCSEDRALRAFERLPGSA 432
S+ E+ S + ++ +RL A
Sbjct: 1770 SKARAEEE--SRSTSEKSKQRLEAEA 1793
Score = 38.1 bits (87), Expect = 0.016
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2116
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2172
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Score = 37.7 bits (86), Expect = 0.021
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2569 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2215
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2216 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2267 QEEAEKMKQVAEE 2279
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2484
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2485 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2543 QLEQQRR----QQEELLAEENQRLREQLQLL 2569
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/192 (25%), Positives = 90/192 (46%), Gaps = 23/192 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1280 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1338
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1339 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1398
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDC 416
A IQAK ++ E + EE+ ++ + E E ELQ + E+ +
Sbjct: 1399 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEA 1455
Query: 417 SEDRALRAFERL 428
+ +A ERL
Sbjct: 1456 QKRQAQEEAERL 1467
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/198 (21%), Positives = 86/198 (43%), Gaps = 27/198 (13%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1677 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1716
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCII 405
+ L EL + + + E ++ +K + E+++ EK + + E ++ E +
Sbjct: 1717 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1776
Query: 406 CSEYFIEQRDCSEDRALR 423
+E QR +E+ A R
Sbjct: 1777 LAEEAKRQRQLAEEDAAR 1794
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2186 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2245
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2246 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2303
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2304 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2360
Score = 40.8 bits (94), Expect = 0.003
Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 50/219 (22%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2322
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2323 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2381
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2382 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2431
Query: 384 AQ-------KEEVLSHMNDVLENELQCIICSEYFIEQRD 415
+ EE+ + + L E Q + + F+ ++D
Sbjct: 2432 QEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKD 2468
Score = 39.7 bits (91), Expect = 0.006
Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 13/168 (7%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2059 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2114
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQT-------K 376
+ + Q KQ +++H E+ R K E + +LE+T
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 377 EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYF--IEQRDCSEDRAL 422
EE ++++A+ E + V E + E ++ R +E+RAL
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222
Score = 39.3 bits (90), Expect = 0.007
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1492 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1540
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1598
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1599 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1640
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/206 (22%), Positives = 98/206 (47%), Gaps = 34/206 (16%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1559 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1618
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1678
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1679 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1737
Query: 407 SEYFIEQRDCSEDRALRAFERLPGSA 432
S+ E+ S + ++ +RL A
Sbjct: 1738 SKARAEEE--SRSTSEKSKQRLEAEA 1761
Score = 38.1 bits (87), Expect = 0.016
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2084
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2140
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2178
Score = 37.7 bits (86), Expect = 0.021
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2420 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2479
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2480 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2536
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2537 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2588
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2183
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2184 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2234
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2235 QEEAEKMKQVAEE 2247
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2653
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2654 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2712 QLEQQRR----QQEELLAEENQRLREQLQLL 2738
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/192 (25%), Positives = 90/192 (46%), Gaps = 23/192 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1449 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1507
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1508 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1567
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDC 416
A IQAK ++ E + EE+ ++ + E E ELQ + E+ +
Sbjct: 1568 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEA 1624
Query: 417 SEDRALRAFERL 428
+ +A ERL
Sbjct: 1625 QKRQAQEEAERL 1636
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/198 (21%), Positives = 86/198 (43%), Gaps = 27/198 (13%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1846 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1885
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCII 405
+ L EL + + + E ++ +K + E+++ EK + + E ++ E +
Sbjct: 1886 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1945
Query: 406 CSEYFIEQRDCSEDRALR 423
+E QR +E+ A R
Sbjct: 1946 LAEEAKRQRQLAEEDAAR 1963
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2355 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2414
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2415 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2472
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2529
Score = 40.8 bits (94), Expect = 0.003
Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 50/219 (22%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2491
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2492 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2550
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2551 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2600
Query: 384 AQ-------KEEVLSHMNDVLENELQCIICSEYFIEQRD 415
+ EE+ + + L E Q + + F+ ++D
Sbjct: 2601 QEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKD 2637
Score = 39.7 bits (91), Expect = 0.006
Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 13/168 (7%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2228 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2283
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQT-------K 376
+ + Q KQ +++H E+ R K E + +LE+T
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 377 EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYF--IEQRDCSEDRAL 422
EE ++++A+ E + V E + E ++ R +E+RAL
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391
Score = 39.3 bits (90), Expect = 0.007
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1661 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1709
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1767
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1768 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1809
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/206 (22%), Positives = 98/206 (47%), Gaps = 34/206 (16%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1787
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1847
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1848 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1906
Query: 407 SEYFIEQRDCSEDRALRAFERLPGSA 432
S+ E+ S + ++ +RL A
Sbjct: 1907 SKARAEEE--SRSTSEKSKQRLEAEA 1930
Score = 38.1 bits (87), Expect = 0.016
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2253
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2309
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2347
Score = 37.7 bits (86), Expect = 0.021
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2589 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2648
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2649 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2705
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2706 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2757
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2352
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2353 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2403
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2404 QEEAEKMKQVAEE 2416
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2494
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2495 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2553 QLEQQRR----QQEELLAEENQRLREQLQLL 2579
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/192 (25%), Positives = 90/192 (46%), Gaps = 23/192 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1290 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1348
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1349 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1408
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDC 416
A IQAK ++ E + EE+ ++ + E E ELQ + E+ +
Sbjct: 1409 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEA 1465
Query: 417 SEDRALRAFERL 428
+ +A ERL
Sbjct: 1466 QKRQAQEEAERL 1477
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/198 (21%), Positives = 86/198 (43%), Gaps = 27/198 (13%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1686
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1687 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1726
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCII 405
+ L EL + + + E ++ +K + E+++ EK + + E ++ E +
Sbjct: 1727 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1786
Query: 406 CSEYFIEQRDCSEDRALR 423
+E QR +E+ A R
Sbjct: 1787 LAEEAKRQRQLAEEDAAR 1804
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2196 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2255
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2256 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2313
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2314 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2370
Score = 40.8 bits (94), Expect = 0.003
Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 50/219 (22%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2332
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2333 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2391
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2392 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2441
Query: 384 AQ-------KEEVLSHMNDVLENELQCIICSEYFIEQRD 415
+ EE+ + + L E Q + + F+ ++D
Sbjct: 2442 QEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKD 2478
Score = 39.7 bits (91), Expect = 0.006
Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 13/168 (7%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2069 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2124
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQT-------K 376
+ + Q KQ +++H E+ R K E + +LE+T
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 377 EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYF--IEQRDCSEDRAL 422
EE ++++A+ E + V E + E ++ R +E+RAL
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232
Score = 39.3 bits (90), Expect = 0.007
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1502 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1550
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1608
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1609 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1650
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/206 (22%), Positives = 98/206 (47%), Gaps = 34/206 (16%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1569 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1628
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1688
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1689 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1747
Query: 407 SEYFIEQRDCSEDRALRAFERLPGSA 432
S+ E+ S + ++ +RL A
Sbjct: 1748 SKARAEEE--SRSTSEKSKQRLEAEA 1771
Score = 38.1 bits (87), Expect = 0.016
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2094
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2150
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2151 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2188
Score = 37.7 bits (86), Expect = 0.021
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2430 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2489
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2490 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2546
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2547 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2598
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2193
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2194 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2244
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2245 QEEAEKMKQVAEE 2257
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2502
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2503 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2561 QLEQQRR----QQEELLAEENQRLREQLQLL 2587
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/192 (25%), Positives = 90/192 (46%), Gaps = 23/192 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1298 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1356
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1357 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1416
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDC 416
A IQAK ++ E + EE+ ++ + E E ELQ + E+ +
Sbjct: 1417 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEA 1473
Query: 417 SEDRALRAFERL 428
+ +A ERL
Sbjct: 1474 QKRQAQEEAERL 1485
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/198 (21%), Positives = 86/198 (43%), Gaps = 27/198 (13%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1694
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1695 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1734
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCII 405
+ L EL + + + E ++ +K + E+++ EK + + E ++ E +
Sbjct: 1735 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1794
Query: 406 CSEYFIEQRDCSEDRALR 423
+E QR +E+ A R
Sbjct: 1795 LAEEAKRQRQLAEEDAAR 1812
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2204 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2263
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2264 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2321
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2322 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2378
Score = 40.8 bits (94), Expect = 0.003
Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 50/219 (22%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2340
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2341 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2399
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2400 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2449
Query: 384 AQ-------KEEVLSHMNDVLENELQCIICSEYFIEQRD 415
+ EE+ + + L E Q + + F+ ++D
Sbjct: 2450 QEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKD 2486
Score = 39.7 bits (91), Expect = 0.006
Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 13/168 (7%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2077 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2132
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQT-------K 376
+ + Q KQ +++H E+ R K E + +LE+T
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 377 EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYF--IEQRDCSEDRAL 422
EE ++++A+ E + V E + E ++ R +E+RAL
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240
Score = 39.3 bits (90), Expect = 0.007
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1510 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1558
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1616
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1617 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1658
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/206 (22%), Positives = 98/206 (47%), Gaps = 34/206 (16%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1577 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1636
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1637 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1696
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1697 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1755
Query: 407 SEYFIEQRDCSEDRALRAFERLPGSA 432
S+ E+ S + ++ +RL A
Sbjct: 1756 SKARAEEE--SRSTSEKSKQRLEAEA 1779
Score = 38.1 bits (87), Expect = 0.016
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2102
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2158
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2159 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2196
Score = 37.7 bits (86), Expect = 0.021
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2438 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2497
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2498 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2554
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2555 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2606
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2201
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2202 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2252
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2253 QEEAEKMKQVAEE 2265
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2543
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2544 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2602 QLEQQRR----QQEELLAEENQRLREQLQLL 2628
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/192 (25%), Positives = 90/192 (46%), Gaps = 23/192 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1339 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1397
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1398 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1457
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDC 416
A IQAK ++ E + EE+ ++ + E E ELQ + E+ +
Sbjct: 1458 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEA 1514
Query: 417 SEDRALRAFERL 428
+ +A ERL
Sbjct: 1515 QKRQAQEEAERL 1526
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/198 (21%), Positives = 86/198 (43%), Gaps = 27/198 (13%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1736 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1775
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCII 405
+ L EL + + + E ++ +K + E+++ EK + + E ++ E +
Sbjct: 1776 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1835
Query: 406 CSEYFIEQRDCSEDRALR 423
+E QR +E+ A R
Sbjct: 1836 LAEEAKRQRQLAEEDAAR 1853
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2245 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2304
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2305 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2362
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2363 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2419
Score = 40.8 bits (94), Expect = 0.003
Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 50/219 (22%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2381
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2382 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2440
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2441 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2490
Query: 384 AQ-------KEEVLSHMNDVLENELQCIICSEYFIEQRD 415
+ EE+ + + L E Q + + F+ ++D
Sbjct: 2491 QEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKD 2527
Score = 39.7 bits (91), Expect = 0.006
Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 13/168 (7%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2118 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2173
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQT-------K 376
+ + Q KQ +++H E+ R K E + +LE+T
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 377 EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYF--IEQRDCSEDRAL 422
EE ++++A+ E + V E + E ++ R +E+RAL
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281
Score = 39.3 bits (90), Expect = 0.007
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1551 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1599
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1657
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1658 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1699
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/206 (22%), Positives = 98/206 (47%), Gaps = 34/206 (16%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1618 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1677
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1678 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1737
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1738 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1796
Query: 407 SEYFIEQRDCSEDRALRAFERLPGSA 432
S+ E+ S + ++ +RL A
Sbjct: 1797 SKARAEEE--SRSTSEKSKQRLEAEA 1820
Score = 38.1 bits (87), Expect = 0.016
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2143
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2199
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2200 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2237
Score = 37.7 bits (86), Expect = 0.021
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2479 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2538
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2539 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2595
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2596 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2647
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2242
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2243 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2293
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2294 QEEAEKMKQVAEE 2306
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 53.9 bits (128), Expect = 3e-07
Identities = 68/310 (21%), Positives = 132/310 (42%), Gaps = 39/310 (12%)
Query: 97 VYSIHQGDYIQLGVPLENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELR-TKRK 155
+ + +G ++ + + E + E++ET + K +++ +K KE++ T +K
Sbjct: 913 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
Query: 156 FSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKG--EVASTPSDNLDPKLTALEPS 213
LD+ A LK ++ + E Q K E+A S + ++ LE +
Sbjct: 973 KLLDQEA--------KLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETN 1024
Query: 214 KTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNV 273
+ +TEVH + S ++ L + I +IQ+QEK + V +
Sbjct: 1025 QK------EQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI--HEIQLQEKEQEVAEL 1076
Query: 274 KKQ------TQKGNSKKVVQMEQE-------LQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
K++ ++ +K++ +++E L +LQ QL Q+ A V L + +
Sbjct: 1077 KQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL----KQKSAHVNSLAQDETKL 1132
Query: 321 EQHLQGLEIAQGEKDLKQQ--LAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEE 378
+ HL+ LE+ K LK+ L + L E L EE R + + ++ ++E + K
Sbjct: 1133 KAHLEKLEV-DLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSS 1191
Query: 379 KEKMQAQKEE 388
EK E+
Sbjct: 1192 HEKSNKSLED 1201
Score = 43.1 bits (100), Expect = 5e-04
Identities = 41/178 (23%), Positives = 82/178 (46%), Gaps = 10/178 (5%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQM 288
E H + ++R Q + R+ + ++++H+ + + K+ ++ ++
Sbjct: 1922 EAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQ 1981
Query: 289 EQELQDLQ-----SQLCAEQAQQQARVEQ-LEKTFQEEEQHLQGLEIAQGEKDLKQQLAQ 342
EQE +L+ QL E Q A+ EQ LE T +E Q +E A+ + +++ Q
Sbjct: 1982 EQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE-AELLESHQEETNQ 2040
Query: 343 ALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENE 400
L++ ++L R+ K +E I+ A+ +E+ + +Q Q EE+ LE E
Sbjct: 2041 LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRD---LQTQLEELQKKYQQKLEQE 2095
Score = 42.0 bits (97), Expect = 0.001
Identities = 40/185 (21%), Positives = 86/185 (46%), Gaps = 22/185 (11%)
Query: 231 HHEQKASNSSASQRSLQMFKVTMSRILRLK----IQMQEKHEA---------VMNVKKQT 277
H + KA +Q ++ + RIL K ++ Q+K V ++ +Q
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 870
Query: 278 QKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLK 337
+K NS +MEQ+++ L ++ EQ ++ E+E + L++ +G+K
Sbjct: 871 EKQNS----EMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI--LQMREGQKKEI 924
Query: 338 QQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVL 397
+ L Q L A + ++ +++E + + K++E+ K++ ++MQ ++ L L
Sbjct: 925 EILTQKLS---AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
Query: 398 ENELQ 402
+ EL+
Sbjct: 982 KKELE 986
Score = 40.4 bits (93), Expect = 0.003
Identities = 38/178 (21%), Positives = 92/178 (51%), Gaps = 17/178 (9%)
Query: 233 EQKASNSSAS----QRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQM 288
EQK + A+ +++L + T +LK +M E+ + + ++ + +++ ++
Sbjct: 403 EQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRV 462
Query: 289 EQELQDLQSQLCAEQAQQQARVEQL-EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEH 347
+QE+ D+ + EQ A++++L EK +EQ L ++ E++ ++Q+ AL++
Sbjct: 463 KQEVVDVMKKSSEEQI---AKLQKLHEKELARKEQELT-KKLQTREREFQEQMKVALEKS 518
Query: 348 WALMEELNRSKKDFEAIIQAKNKELEQTK-----EEKEKMQAQKEEVLSHMNDVLENE 400
+ ++++ K+ E++ +ELE K E + K++ ++E ++ +LE E
Sbjct: 519 QSEYLKISQEKEQQESLAL---EELELQKKAILTESENKLRDLQQEAETYRTRILELE 573
Score = 40.0 bits (92), Expect = 0.004
Identities = 56/315 (17%), Positives = 127/315 (40%), Gaps = 54/315 (17%)
Query: 145 EKNKELRTKRKFSLDE----LAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGEVASTPS 200
+K +E R K K +DE + E +L+ ++++V E +K + ++A
Sbjct: 424 QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIA---- 479
Query: 201 DNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLK 260
K+ ++H ++ A + LQ + +++
Sbjct: 480 -------------------------KLQKLHEKELARKEQELTKKLQTREREFQEQMKVA 514
Query: 261 IQMQEKHEAVMNVKKQTQKGNS-------KKVVQMEQE--LQDLQSQLCAEQAQQQARVE 311
++ + ++ +K+ Q+ + KK + E E L+DLQ + + +
Sbjct: 515 LEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELES 574
Query: 312 QLEKTFQEEEQHLQGLEI-AQGEKDL-KQQLAQALQEHWALMEELNRSK-----KDFEAI 364
LEK+ QE + + L + + EK+ +++ +++H +E L + + + +
Sbjct: 575 SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVL 634
Query: 365 IQAKNKELEQTKE----EKEKMQAQKEEVL-SHMNDVLENELQCIICSEYFIEQRDCSED 419
Q E+E+ +E EKE + KE + +H+ ++ E L+ + + +E
Sbjct: 635 KQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELS 694
Query: 420 RALRAFERLPGSASL 434
L+A +L S+
Sbjct: 695 EVLKARHKLEEELSV 709
Score = 38.9 bits (89), Expect = 0.010
Identities = 38/186 (20%), Positives = 93/186 (50%), Gaps = 20/186 (10%)
Query: 236 ASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKG---NSKKVVQMEQEL 292
A +L+M + ++++ QM + E + K+++++ +K + Q+
Sbjct: 367 AETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKT 426
Query: 293 QDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALME 352
++ + +L AE +Q ++ +EKT +EE LQ E+++ ++++ + ++ +E A ++
Sbjct: 427 EEARRKLKAEMDEQ---IKTIEKTSEEERISLQ-QELSRVKQEVVDVMKKSSEEQIAKLQ 482
Query: 353 -----ELNRSKKDFEAIIQAKNKE--------LEQTKEEKEKMQAQKEEVLSHMNDVLEN 399
EL R +++ +Q + +E LE+++ E K+ +KE+ S + LE
Sbjct: 483 KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542
Query: 400 ELQCII 405
+ + I+
Sbjct: 543 QKKAIL 548
Score = 38.5 bits (88), Expect = 0.012
Identities = 71/313 (22%), Positives = 131/313 (41%), Gaps = 47/313 (15%)
Query: 123 EVTEEDWETIYPCLSPKNDQMIEKNKELRTKR---KFSLDELAGPGAEGPSNLKSKINKV 179
+V ++ ++T L K +Q EK L+ K + ++E+ E ++++ +
Sbjct: 632 QVLKQQYQTEMEKLREKCEQ--EKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESL 689
Query: 180 SCESGQPVKSQGK-GEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASN 238
S E + +K++ K E S D D LE + HH+Q+ +
Sbjct: 690 SSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDE-----------QKNHHQQQVDS 738
Query: 239 SSASQR-SLQMF-KVTMSRILRLKIQMQEK------HEAVMNVKKQTQKGNSKKVVQMEQ 290
S+Q K +I +L++ ++E+ H+A + + K + ++ Q
Sbjct: 739 IIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA 798
Query: 291 ELQDLQSQLCAEQAQQQARVEQLEKTFQ-----EEEQHLQGLEIAQGE---KDLKQQLAQ 342
+L QS A Q +A EQL + Q E E+ L ++A+ E KD+ +L
Sbjct: 799 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDA 858
Query: 343 ALQEHWALMEELNRSKKD-----------FEAIIQAKNKELEQTKE---EKEKMQAQKEE 388
+ LM++L + + +E+ ++ NKE EQTK+ EKE M Q E
Sbjct: 859 HKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMRE 918
Query: 389 VLSHMNDVLENEL 401
++L +L
Sbjct: 919 GQKKEIEILTQKL 931
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/187 (24%), Positives = 84/187 (44%), Gaps = 21/187 (11%)
Query: 259 LKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQ 318
LK Q + +A + K++ + + + VV+ ++ L++ Q+ R E L K +
Sbjct: 245 LKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETL-----QQRVKRQENLLKRCK 299
Query: 319 EEEQ-HLQGLEIAQGEKD-LKQQLAQALQE-------HWA----LMEELNRSKKDFEAII 365
E Q H + + EK+ L++QL + LQE H A L+ +L +K E +
Sbjct: 300 ETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLE 359
Query: 366 QAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDCSEDRALRAF 425
Q K + +TK + + KEE ++ + ++ Q E EQ++ SE A
Sbjct: 360 QDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK---QMTTQGEELREQKEKSERAAFEEL 416
Query: 426 ERLPGSA 432
E+ +A
Sbjct: 417 EKALSTA 423
Score = 38.1 bits (87), Expect = 0.016
Identities = 43/228 (18%), Positives = 95/228 (41%), Gaps = 37/228 (16%)
Query: 201 DNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLK 260
+ LD K T LE + +V + H+ + S ++ +M + +++ K
Sbjct: 677 EKLDVKQTELESLSSE-------LSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK 729
Query: 261 IQMQEKHEAVMNVKK----QTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKT 316
Q++ ++++ + +T+K ++ Q+E L++ L + QA VE LE
Sbjct: 730 NHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHL----KEHQAHVENLEAD 785
Query: 317 FQEEEQHLQG----LEIAQGEKDLKQQLAQALQEHWALME------------------EL 354
+ E LQ L++ Q + + +A +E A ++ E+
Sbjct: 786 IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEV 845
Query: 355 NRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQ 402
KKD + A +++ ++ EK ++ E+ + + V E++L+
Sbjct: 846 EAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE 893
Score = 36.2 bits (82), Expect = 0.062
Identities = 34/143 (23%), Positives = 68/143 (47%), Gaps = 12/143 (8%)
Query: 243 QRSLQMFKVTMSRILRLKIQMQE-----KHEAVMNVKKQTQKGNSKKVVQMEQELQDLQS 297
Q+ L++ K + KI+ ++ KH + + KQ + + ++ Q EQEL+
Sbjct: 1961 QQELEILKKEYDQEREEKIKQEQEDLELKHNSTL---KQLMREFNTQLAQKEQELEMTIK 2017
Query: 298 QLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRS 357
+ + Q+ E LE +E Q L+ +IA+ + DLK+ + + A EE+
Sbjct: 2018 ETINKA--QEVEAELLESHQEETNQLLK--KIAEKDDDLKRTAKRYEEILDAREEEMTAK 2073
Query: 358 KKDFEAIIQAKNKELEQTKEEKE 380
+D + ++ K+ +Q E++E
Sbjct: 2074 VRDLQTQLEELQKKYQQKLEQEE 2096
Score = 35.8 bits (81), Expect = 0.081
Identities = 41/154 (26%), Positives = 77/154 (50%), Gaps = 18/154 (11%)
Query: 263 MQEKHEAVMNVKKQTQKGNSKKVVQMEQ---ELQDLQSQLCAEQAQQQAR-----VEQLE 314
+QEK ++++ ++ +S V Q E E+++L S+ QA QQ E LE
Sbjct: 1842 LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901
Query: 315 KTFQEEEQ-HLQGLEIAQG----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKN 369
+ +E+ + HL ++ DL+ +LA A +E L +E+ R +KD + +
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961
Query: 370 KELEQTKEE-----KEKMQAQKEEVLSHMNDVLE 398
+ELE K+E +EK++ ++E++ N L+
Sbjct: 1962 QELEILKKEYDQEREEKIKQEQEDLELKHNSTLK 1995
Score = 35.0 bits (79), Expect = 0.14
Identities = 39/225 (17%), Positives = 89/225 (39%), Gaps = 32/225 (14%)
Query: 202 NLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKI 261
+LD + +P + ++ EQ +RSL ++ S ++
Sbjct: 106 DLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQ 165
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE 321
+Q + + + + Q+Q + +++ ++ +ELQ +Q ++ E+ + + +E++
Sbjct: 166 MLQREKKKLQGILSQSQDKSLRRIAELREELQ-------MDQQAKKHLQEEFDASLEEKD 218
Query: 322 QHL-----------QGLEIAQGEKDLKQQLAQALQEHWALMEELN------------RSK 358
Q++ Q L D+ + L Q + +E N S
Sbjct: 219 QYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSV 278
Query: 359 KDFEAIIQAKNKELEQTKEEKEKMQAQKEE--VLSHMNDVLENEL 401
K E + Q ++ K KE +Q+ KE+ +L+ + L+ +L
Sbjct: 279 KTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQL 323
Score = 34.3 bits (77), Expect = 0.24
Identities = 61/295 (20%), Positives = 120/295 (40%), Gaps = 57/295 (19%)
Query: 98 YSIHQGDYIQLGVPLENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFS 157
++ HQ +L + LE K YE D+ I KE ++
Sbjct: 1453 FTQHQNTVKELQIQLELKSKEAYE------------------KDEQINLLKEELDQQNKR 1494
Query: 158 LDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTG 217
D L G + S ++ K + + E +KSQ ++ LE T
Sbjct: 1495 FDCLKGEMEDDKSKMEKKESNLETE----LKSQ-------------TARIMELEDHITQK 1537
Query: 218 APIYPGFPKVTEVHHEQKASNSSASQRSLQMF-----------KVTMSRILRLKIQMQEK 266
+V + +++QK + LQ F K +IL L+ Q+
Sbjct: 1538 TIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSM 1597
Query: 267 HEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQG 326
+A + KK+ + + V E+EL+ L+ +L +E A A++ +L++ +++ ++
Sbjct: 1598 -KAELETKKKELEHVNLSVKSKEEELKALEDRLESESA---AKLAELKRKAEQKIAAIKK 1653
Query: 327 LEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA---IIQAKNKELEQTKEE 378
++Q E + ++Q + + H + ELN ++ E I++ K K +E ++ E
Sbjct: 1654 QLLSQME-EKEEQYKKGTESH---LSELNTKLQEREREVHILEEKLKSVESSQSE 1704
Score = 32.7 bits (73), Expect = 0.68
Identities = 33/170 (19%), Positives = 76/170 (44%), Gaps = 9/170 (5%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGN----SKK 284
E+ ++K N+ + + + RL+ +E+ E++ V ++ KK
Sbjct: 991 ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK 1050
Query: 285 VVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQ-----Q 339
+ Q +ELQ++ E+ Q+ A ++Q F E++ + E+ +KQ +
Sbjct: 1051 LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110
Query: 340 LAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
L + L++ A + L + + +A ++ +L ++ +E +Q Q E+
Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVEL 1160
Score = 30.8 bits (68), Expect = 2.6
Identities = 35/168 (20%), Positives = 72/168 (42%), Gaps = 32/168 (19%)
Query: 265 EKHEAVMNVKKQTQKGNSKKVVQMEQELQD----------------LQSQLCAEQAQQQA 308
EK + +KK+ + N V M++EL++ +Q Q ++++A
Sbjct: 1336 EKESCITQLKKELSE-NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEA 1394
Query: 309 RVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNR--------SKKD 360
+ L K + EE+ E+ +DL ++ +E + +E+++ KK
Sbjct: 1395 AISSLRKQYDEEK-----CELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449
Query: 361 FEAIIQAKN--KELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
Q +N KEL+ E K K +K+E ++ + + L+ + + C
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC 1497
Score = 30.4 bits (67), Expect = 3.4
Identities = 34/167 (20%), Positives = 71/167 (42%), Gaps = 25/167 (14%)
Query: 260 KIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQE 319
KI E+ + N + +K + Q + +++LQ QL + + + EQ+ +E
Sbjct: 1428 KISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEE 1487
Query: 320 EEQHLQGLEIAQG----------------EKDLKQQLAQ--ALQEHWAL----MEELNRS 357
+Q + + +G E +LK Q A+ L++H +E LN
Sbjct: 1488 LDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEV 1547
Query: 358 KKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMND---VLENEL 401
K++ ++KEL Q + +++ +K+ + + LEN++
Sbjct: 1548 LKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQV 1594
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 53.1 bits (126), Expect = 5e-07
Identities = 74/314 (23%), Positives = 140/314 (44%), Gaps = 45/314 (14%)
Query: 107 QLGVPLENKENAEYEYE--VTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLD-ELAG 163
+L PL ++E A+ TEE+ P P+ ++ +EL SL +L+
Sbjct: 470 RLSPPLPHEERAQSPPRSLATEEE-----PPQGPEGQPEWKEAEELGEDSAASLSLQLSL 524
Query: 164 PGAEGPSNLKSKINKVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPG 223
+ PS +CE G+ SQ + E+ + DP+ K +P P
Sbjct: 525 QREQAPSP------PAACEKGKEQHSQAE-ELGPGQEEAEDPE------EKVAVSPTPPV 571
Query: 224 FPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQ--MQEKHEAVMNVKKQTQKGN 281
P+V E A S+ +L+ + ++++L + ++ K E + ++++ +
Sbjct: 572 SPEVRST--EPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEE 629
Query: 282 SKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEI-----AQGEKD- 335
++++++ Q+ + S L + Q+A E+ + +EE Q L L Q ++D
Sbjct: 630 EEEILRLHQQKEQSLSSL--RERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQ 687
Query: 336 LKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKE-LEQTKEEKE--------KMQAQK 386
++ + +LQ+ L EEL +K A ++ KN++ LEQ KEE E + A K
Sbjct: 688 IRAEQEASLQK---LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAK 744
Query: 387 EEVLSHMNDVLENE 400
E+ L + + LE E
Sbjct: 745 EKALQQLREQLEGE 758
Score = 43.1 bits (100), Expect = 5e-04
Identities = 41/155 (26%), Positives = 77/155 (49%), Gaps = 16/155 (10%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKK-----VVQMEQELQDLQS----QLCAEQAQQQARVEQ 312
+M+E+H+ VM ++ + +K + + EL+ LQ +L + +Q R+E
Sbjct: 853 KMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLED 912
Query: 313 LEKTFQEEEQHLQGLE--IAQGEKDLKQQLA-QALQEHWALMEELNRSKKDFEAIIQAKN 369
L + +E+E+ LQ LE + KD+K +LA +QE A E+ + D + + K+
Sbjct: 913 LRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREK--QQLLDVQRQVALKS 970
Query: 370 KELEQTKEEKEKMQAQKEEVLSHMNDVLE--NELQ 402
+E T ++ E+ Q + +L + E +ELQ
Sbjct: 971 EEATATHQQLEEAQKEHTHLLQSNQQLREILDELQ 1005
Score = 40.4 bits (93), Expect = 0.003
Identities = 44/198 (22%), Positives = 78/198 (39%), Gaps = 38/198 (19%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQE-----KHEAVMNVKKQTQKGNSK 283
E+ +QKA +S Q++ QM + I + Q K +A+ +++Q + +
Sbjct: 702 ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKE 761
Query: 284 KVVQMEQELQDLQSQLCA-----------------------EQAQQQARVEQLEKTFQEE 320
V +E+E +LC+ E+AQ Q + Q+E ++
Sbjct: 762 AVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQK 821
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKE 380
H+ G E +L L + QE E K+ + AK +E + +E K
Sbjct: 822 SYHVAGY-----EHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERK- 875
Query: 381 KMQAQKEEVLSHMNDVLE 398
Q+ E+L H+ LE
Sbjct: 876 ----QRAELLGHLTGELE 889
Score = 38.1 bits (87), Expect = 0.016
Identities = 41/182 (22%), Positives = 82/182 (45%), Gaps = 25/182 (13%)
Query: 226 KVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV 285
++ +H +++ S SS +R + + +R+ + Q A V+ TQ +
Sbjct: 632 EILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRA--QVQSSTQADEDQIR 689
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE--------------------EQHLQ 325
+ E LQ L+ +L ++Q ++A +EQ + E+ E+ LQ
Sbjct: 690 AEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALMEELNRS-KKDFEAIIQAKNKELEQTKEEKEKMQA 384
L Q E + K+ +A +EH A +E L S + ++ + K++++ ++KE+ Q
Sbjct: 750 QLR-EQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEA-QQKEEAQL 807
Query: 385 QK 386
QK
Sbjct: 808 QK 809
Score = 37.7 bits (86), Expect = 0.021
Identities = 39/170 (22%), Positives = 78/170 (45%), Gaps = 17/170 (10%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSR----ILRLKIQMQEKHEAVMNVKKQTQKGNSKK 284
E+ E +A + A L++ + T R +L ++ Q+ K E +Q ++ +
Sbjct: 928 ELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEH 987
Query: 285 --VVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQ 342
++Q Q+L+++ +L A + + +++V+ L+ Q+ ++H LE E KQ L +
Sbjct: 988 THLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLE---AEAQKKQHLLR 1044
Query: 343 ALQEHWALMEELNRS---KKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
+ +EE N S + D K+ QTKE + KE++
Sbjct: 1045 EV-----TVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDL 1089
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 52.8 bits (125), Expect = 6e-07
Identities = 62/304 (20%), Positives = 139/304 (45%), Gaps = 33/304 (10%)
Query: 113 ENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNL 172
E E+ + YE+ E+ ET+ + + E+NK+ +++ +E G+ G + +
Sbjct: 151 EKSESRQERYEI--EETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQV 208
Query: 173 KSKINKVSCESGQP--VKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEV 230
+ + + + ES + V S G+++S +PK E + G+ K+ E
Sbjct: 209 EVMVEEKTTESQEETVVMSLKNGQISSE-----EPKQ---EEEREQGSDEISHHEKMEEE 260
Query: 231 HHEQ-KASNSSASQRSLQMFKVTMSRIL---RLKIQMQEKHEAVMNVKKQTQ-----KGN 281
E+ +A + + K + + R +I+ +EK A +++ + +
Sbjct: 261 DKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREE 320
Query: 282 SKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLA 341
K+ + Q +++ + + A+++ R+++ EK EE Q ++ E E+ +Q A
Sbjct: 321 EKRAAEERQRIKEEEKRA----AEERQRIKEEEKRAAEERQRIKEEEKRAAEE---RQRA 373
Query: 342 QALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
+A +E A +EE R+K+ ++ K +++TK + EK++ + E + E++L
Sbjct: 374 RAEEEEKAKVEEQKRNKQ-----LEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKL 428
Query: 402 QCII 405
Q +
Sbjct: 429 QTAV 432
Score = 33.1 bits (74), Expect = 0.52
Identities = 35/171 (20%), Positives = 78/171 (45%), Gaps = 14/171 (8%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRI------LRLKIQMQEKHEAVMNVKKQTQKGNSKKVV 286
E+K + A + LQ K T + ++ + +E+ ++ M+ KK + S+
Sbjct: 438 EEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE 497
Query: 287 QMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE-QHLQGLEIAQGEKDLKQ--QLAQA 343
M +L+ ++ + ++ E Q E + L+ L +GE + ++ +L Q
Sbjct: 498 FMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQK 557
Query: 344 LQEHWALMEELNRSKKDFEAIIQA-----KNKELEQTKEEKEKMQAQKEEV 389
QE +EEL + +++ +++ K +E ++ E+E+ + KEE+
Sbjct: 558 QQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEI 608
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 51.6 bits (122), Expect = 1e-06
Identities = 39/207 (18%), Positives = 102/207 (49%), Gaps = 14/207 (6%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNS-KKVVQMEQE 291
E++ +R LQ R R + ++Q++ E ++ +++T++ ++ + E+E
Sbjct: 1030 EEQLLREEREKRRLQ----ERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE 1085
Query: 292 LQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALM 351
LQ + QL E+ +++ R E+ + +EEE + ++ + E++ +++ Q L+ +
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR--QELERQYREE 1143
Query: 352 EELNRSKKDF--EAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEY 409
EE+ + ++ E + + +ELE+ E+E++Q ++E++L + E +
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE-----RQ 1198
Query: 410 FIEQRDCSEDRALRAFERLPGSASLRW 436
+ E+ + + + + + L+W
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKW 1225
Score = 46.2 bits (108), Expect = 6e-05
Identities = 34/140 (24%), Positives = 79/140 (56%), Gaps = 7/140 (5%)
Query: 255 RILRLKIQMQEKHEAVMNVKKQTQKGNSK-KVVQMEQELQDLQSQLCAEQAQQQARVEQL 313
R R K ++Q++ E ++ +++ ++ + + + E+ELQ + QL E+ + + R ++L
Sbjct: 1018 RQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR-QEL 1076
Query: 314 EKTFQEEE---QHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
E+ +++EE Q + L + EK +Q+ + +E L +E + + E + + +
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR--EEREKRRRQ 1134
Query: 371 ELEQTKEEKEKMQAQKEEVL 390
ELE+ E+E++Q ++E++L
Sbjct: 1135 ELERQYREEEEVQQEEEQLL 1154
Score = 45.8 bits (107), Expect = 8e-05
Identities = 40/186 (21%), Positives = 86/186 (46%), Gaps = 17/186 (9%)
Query: 229 EVHHEQKASNSSASQRSLQMFK--VTMSRILRLKIQMQEKHEAVMNVKKQTQKGNS---K 283
E EQ+ +R Q + + R +L+ + Q + E + ++Q ++ +
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE-------EQHLQGLEIAQGEKDL 336
+ ++ EQ+L+ Q + EQ +Q R EQ K QEE E+ + E + ++ L
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 337 KQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDV 396
K+ + +E W +EE R ++ + + ++L + +EE+ + + +++E +
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQ-----ERREQQLRREQEERREQRLKRQEEEERLQQR 531
Query: 397 LENELQ 402
L +E Q
Sbjct: 532 LRSEQQ 537
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/161 (22%), Positives = 82/161 (50%), Gaps = 6/161 (3%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQM 288
++ EQ+ +R + R RLK + +E+ + ++ +++ ++ K+ +
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR--EQ 594
Query: 289 EQELQDLQSQLCAEQAQQQARVEQ-LEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEH 347
E+ L+ + E+ +Q+ R EQ L++ EEE+ Q L+ + E+ +QQL + QE
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654
Query: 348 WALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEE 388
E+ + +++ E + Q +E E+ + E+E + ++E+
Sbjct: 655 ---REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Score = 45.4 bits (106), Expect = 1e-04
Identities = 30/129 (23%), Positives = 73/129 (56%), Gaps = 4/129 (3%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
QE+ + + +++ ++ ++ + + ELQ + QL E+ +++ R+++ E+ ++EEE+
Sbjct: 998 QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE-REKRRLQERERQYREEEEL 1056
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDF--EAIIQAKNKELEQTKEEKEK 381
Q E GE + + + Q L+ + EEL + ++ E + + +E E+ E+E+
Sbjct: 1057 QQEEEQLLGE-ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115
Query: 382 MQAQKEEVL 390
+Q ++E++L
Sbjct: 1116 LQQEEEQLL 1124
Score = 42.4 bits (98), Expect = 9e-04
Identities = 39/159 (24%), Positives = 74/159 (46%), Gaps = 16/159 (10%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQEL 292
E+K+ + + R LR + + Q + + +++ Q+ ++ + E+EL
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRR--EREKEL 831
Query: 293 QDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALME 352
Q L+ + EQ Q++ R +QL QEEE LQ E+ Q+ + + W L E
Sbjct: 832 QFLEEE---EQLQRRERAQQL----QEEEDGLQ----EDQERRRSQEQRRDQKWRWQLEE 880
Query: 353 ELNRSKKDF---EAIIQAKNKELEQTKEEKEKMQAQKEE 388
E R + A+ + KE + +EE+E++Q ++ E
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE 919
Score = 42.0 bits (97), Expect = 0.001
Identities = 35/164 (21%), Positives = 77/164 (46%), Gaps = 15/164 (9%)
Query: 260 KIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-----LE 314
++ +E+ E +++ ++ ++ + E++LQ + QL E+ +++ R E+ +
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 315 KTFQEEEQHLQGLE-----IAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKN 369
K Q++E+ L G E + EK +++ +E L EE + ++ K
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 370 KELEQ-----TKEEKEKMQAQKEEVLSHMNDVLENELQCIICSE 408
EL+Q +EE+EK + Q+ E + L+ E + ++ E
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE 1067
Score = 41.2 bits (95), Expect = 0.002
Identities = 49/206 (23%), Positives = 87/206 (42%), Gaps = 43/206 (20%)
Query: 226 KVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQE------KHEAVMNVKKQTQK 279
++ + EQ+ +R + + R RLK + +E K E V ++++ ++
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616
Query: 280 GNSKKVVQMEQELQD--LQSQLCAEQAQQQARVEQLEKTFQ------EEEQHLQGLEIAQ 331
K + E+E + L+S+ E+ QQQ R EQ E+ Q EEE+ Q L+
Sbjct: 617 EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREH 676
Query: 332 GEKDLKQQLAQALQEH-------------WALMEELN----------------RSKKDFE 362
E+ +Q+LA+ QE W L E + R +++ E
Sbjct: 677 EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE 736
Query: 363 AIIQAKNKELEQTKEEKEKMQAQKEE 388
+ + EL+ +EE+ Q Q+EE
Sbjct: 737 EKRRRRESELQWQEEERAHRQQQEEE 762
Score = 40.8 bits (94), Expect = 0.003
Identities = 30/142 (21%), Positives = 76/142 (53%), Gaps = 11/142 (7%)
Query: 260 KIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQS-QLCAEQAQQQARVEQLEKTFQ 318
+++ QE++ ++ ++ + +++ + E++ + + QL E+ +QQ R ++ ++ F+
Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR 1798
Query: 319 EEEQHLQGLEIAQ-------GEKDLKQQLAQALQEHWALMEELN---RSKKDFEAIIQAK 368
EEEQ Q E Q G+ +++ Q ++ L +E + R+++ F +++
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSR 1858
Query: 369 NKELEQTKEEKEKMQAQKEEVL 390
+E E +EE++K + ++E L
Sbjct: 1859 REEQELWQEEEQKRRQERERKL 1880
Score = 40.4 bits (93), Expect = 0.003
Identities = 32/139 (23%), Positives = 73/139 (52%), Gaps = 9/139 (6%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTF 317
R + Q +++H ++Q ++ K+ + +++ Q+ + QL E+ +++ R ++ ++ F
Sbjct: 1283 RRRWQQRDRH---FPEEEQLEREEQKEAKRRDRKSQE-EKQLLREEREEKRRRQETDRKF 1338
Query: 318 QEEEQHLQGLEIAQGEKDL-KQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTK 376
+EEEQ LQ E E+ L +Q+ + +E +E R + E ++ + +E + K
Sbjct: 1339 REEEQLLQERE----EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLK 1394
Query: 377 EEKEKMQAQKEEVLSHMND 395
EE++ ++E+ L D
Sbjct: 1395 EEQQLRCQEREQQLRQDRD 1413
Score = 40.4 bits (93), Expect = 0.003
Identities = 34/141 (24%), Positives = 68/141 (48%), Gaps = 14/141 (9%)
Query: 260 KIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQA--------QQQARVE 311
+++ QE+ + ++Q ++ +K + EQ LQ+ + Q Q +QQ R +
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Query: 312 QLEKTFQEEEQHLQGLE--IAQGEKDLKQQLAQA--LQEHWALMEELNRSKKDFEAIIQA 367
+ ++ F+E+E Q E + E+ L +Q Q LQE L + ++ +
Sbjct: 1498 ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR--DR 1555
Query: 368 KNKELEQTKEEKEKMQAQKEE 388
K +E EQ ++E+E+ Q ++E
Sbjct: 1556 KFREEEQLRQEREEQQLSRQE 1576
Score = 39.7 bits (91), Expect = 0.006
Identities = 26/115 (22%), Positives = 62/115 (53%), Gaps = 4/115 (3%)
Query: 274 KKQTQKGNSKKVVQMEQELQ--DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQ 331
K+Q ++ +V Q E+E + ++ L E+ + Q Q ++ QEEE+ L+ LE +
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 332 GEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQK 386
++ +++ Q Q+ ++L R +++ Q + +E ++ +E++E+ + Q+
Sbjct: 286 LRRERQEEEQQ--QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338
Score = 39.7 bits (91), Expect = 0.006
Identities = 37/180 (20%), Positives = 85/180 (47%), Gaps = 12/180 (6%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQE-LQDLQSQLCAEQAQQQARVEQLEKTF--- 317
Q +E+ + V +++ + + V++ E+E LQ+ + Q E +++ ++ +LE+
Sbjct: 229 QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRR 288
Query: 318 --QEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQT 375
QEEEQ Q L + E+ L+++ + +E EE ++ E + + ++L +
Sbjct: 289 ERQEEEQQQQRL---RREQQLRRKQEEERREQ---QEERREQQERREQQEERREQQLRRE 342
Query: 376 KEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDCSEDRALRAFERLPGSASLR 435
+EE+ + Q ++E+ L E + + ++ ++ LR ++L LR
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR 402
Score = 39.7 bits (91), Expect = 0.006
Identities = 28/129 (21%), Positives = 67/129 (51%), Gaps = 7/129 (5%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE 321
Q +E+ + + ++++ Q ++ Q+++E LQ ++Q+Q R ++ +Q EE
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR--WQLEE 880
Query: 322 QHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEK 381
+ + + L++QL + Q EEL R +++ + + +E E+ E+E+
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE-----KRRRQEQERQYREEEQ 935
Query: 382 MQAQKEEVL 390
+Q ++E++L
Sbjct: 936 LQQEEEQLL 944
Score = 38.9 bits (89), Expect = 0.010
Identities = 38/178 (21%), Positives = 84/178 (47%), Gaps = 10/178 (5%)
Query: 226 KVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV 285
K E EQ+ +R Q + R +L+ + +E+ E ++++ ++ ++
Sbjct: 309 KQEEERREQQEERREQQERREQQEE---RREQQLRREQEERRE--QQLRREQEEERREQQ 363
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQ-EEEQHLQGLEIAQGEKDLKQQLAQAL 344
++ EQE + + QL E QQ R +QL + Q EQ L+ + + E+ L+++ Q L
Sbjct: 364 LRREQEEERREQQLRRE--QQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE--QQL 419
Query: 345 QEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQ 402
+ L E + + + + + + L++ +EE+ ++EE H + + +L+
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477
Score = 38.9 bits (89), Expect = 0.010
Identities = 39/135 (28%), Positives = 69/135 (51%), Gaps = 18/135 (13%)
Query: 265 EKHEAVMNVKKQTQKGNSKKVVQMEQ-ELQDLQSQ-----LCAEQA-----QQQARVEQL 313
EK AV + K + +++ Q+E +L+D QSQ L EQ Q++ R +Q
Sbjct: 1230 EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR 1289
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
++ F EEEQ LE + +K+ K++ ++ +E L EE ++ E K +E E
Sbjct: 1290 DRHFPEEEQ----LE-REEQKEAKRRDRKSQEEKQLLREEREEKRRRQET--DRKFREEE 1342
Query: 374 QTKEEKEKMQAQKEE 388
Q +E+E+ +++E
Sbjct: 1343 QLLQEREEQPLRRQE 1357
Score = 38.9 bits (89), Expect = 0.010
Identities = 36/135 (26%), Positives = 68/135 (50%), Gaps = 20/135 (14%)
Query: 274 KKQTQKGNSKKVVQMEQELQDLQSQLCAEQA--------QQQARVEQLEKTFQEEEQHLQ 325
++Q + +K + EQ LQ+ + Q Q +QQ R ++ E+ F +EEQ L+
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR 1717
Query: 326 GLEIA---QGEKDLKQQLAQ---ALQEHW--ALMEELNRSKKDFEAIIQ----AKNKELE 373
E+ + E+ L+Q+ Q QE + L EE R +++ + + + K +E E
Sbjct: 1718 RQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE 1777
Query: 374 QTKEEKEKMQAQKEE 388
Q ++E+E+ Q + +E
Sbjct: 1778 QLRQEREEQQLRSQE 1792
Score = 38.1 bits (87), Expect = 0.016
Identities = 36/174 (20%), Positives = 80/174 (45%), Gaps = 17/174 (9%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE 321
++QE+ E + +++Q + ++ Q +Q L+ + QQ R ++ E+ Q+EE
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLR---------REQQLRRKQEEERREQQEE 320
Query: 322 QHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEK 381
+ Q Q E+ +QQL + +E ++L R +++ + + ++L + +EE+ +
Sbjct: 321 RREQQERREQQEERREQQLRREQEER--REQQLRREQEE-----ERREQQLRREQEEERR 373
Query: 382 MQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDCSEDRALRAFERLPGSASLR 435
Q + E L E Q + + ++ ++ LR ++L LR
Sbjct: 374 EQQLRREQQLRREQQLRREQQ-LRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Score = 38.1 bits (87), Expect = 0.016
Identities = 40/170 (23%), Positives = 78/170 (45%), Gaps = 19/170 (11%)
Query: 243 QRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDL-----QS 297
Q + F ++ R + Q Q + E ++ Q ++ Q+ ++ +D +
Sbjct: 1591 QEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEP 1650
Query: 298 QLCAEQAQQQARVEQLEKTFQEE-------EQHLQGLEIAQGEKDLKQQLAQALQEHWAL 350
QL ++ +QQ R ++ K +EE EQ L+ E + ++ +QQL + +E L
Sbjct: 1651 QLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL 1710
Query: 351 MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENE 400
EE +++ E K +E EQ ++E E+ Q +++E +LE E
Sbjct: 1711 QEEQQLRRQELE----RKFREEEQLRQETEQEQLRRQE---RYRKILEEE 1753
Score = 38.1 bits (87), Expect = 0.016
Identities = 28/113 (24%), Positives = 62/113 (54%), Gaps = 9/113 (7%)
Query: 283 KKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQ 342
+K + EQ+L+ + + Q +QQ R ++LE+ F+EEEQ Q E ++QL +
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE--------QEQLRR 1742
Query: 343 ALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMND 395
+ L EE R +++ E ++ + ++ + +EE+ + + +++++ S +D
Sbjct: 1743 QERYRKILEEEQLRPERE-EQQLRRQERDRKFREEEQLRQEREEQQLRSQESD 1794
Score = 37.7 bits (86), Expect = 0.021
Identities = 34/164 (20%), Positives = 76/164 (46%), Gaps = 2/164 (1%)
Query: 227 VTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVV 286
V E+ QR LQ + + ++ R +++ + + E + + ++ +K
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE 311
Query: 287 QMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQE 346
+ +E Q+ + + + QQ+ R EQ + QEE + Q L Q E+ +QQL + QE
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRREQEERRE-QQLRREQEEERREQQLRRE-QE 369
Query: 347 HWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVL 390
++L R ++ + ++L + ++ + + Q ++E+ L
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
Score = 37.7 bits (86), Expect = 0.021
Identities = 38/183 (20%), Positives = 88/183 (48%), Gaps = 27/183 (14%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQM 288
++ EQ+ +R Q+ + + LR + Q++ + E + +K Q+ +++ +
Sbjct: 394 QLRREQQLRREQQLRREQQLRR---EQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450
Query: 289 EQELQD-LQSQLCAEQAQQQARVEQLEKTFQEE--------------------EQHLQGL 327
++E +D L+ + E+ +Q+ R +QL++ +EE EQ L+
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510
Query: 328 EIAQGEKDLK-QQLAQALQEHWALMEELNRSKKD--FEAIIQAKNKELEQTKEEKEKMQA 384
+ + E+ LK Q+ + LQ+ ++L R +++ + + + + K LEQ + E+ +
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 385 QKE 387
Q+E
Sbjct: 571 QEE 573
Score = 37.7 bits (86), Expect = 0.021
Identities = 28/133 (21%), Positives = 67/133 (50%), Gaps = 5/133 (3%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTF 317
RLK + E+ +K + Q+ ++ Q+ +E Q+ + Q + +++ R+EQ K
Sbjct: 619 RLKREEPEEERRQQLLKSEEQE--ERRQQQLRREQQERREQRLKRE-EEEERLEQRLKRE 675
Query: 318 QEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKE 377
EEE+ Q E+A+ E++ ++ ++ W E + + + + +E ++ ++
Sbjct: 676 HEEERREQ--ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ 733
Query: 378 EKEKMQAQKEEVL 390
E+E+ + ++E L
Sbjct: 734 EQEEKRRRRESEL 746
Score = 37.7 bits (86), Expect = 0.021
Identities = 41/177 (23%), Positives = 78/177 (44%), Gaps = 12/177 (6%)
Query: 260 KIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQE 319
K +E+ ++Q ++ +K + EQ+L + + +QQ R ++ E+ F E
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE 1450
Query: 320 EEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQ-----AKNKELEQ 374
EEQ L+ + ++ +QL Q +E +E +R + E ++ K +E E
Sbjct: 1451 EEQQLRQERHRKFREE--EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL 1508
Query: 375 TKEEKEKMQAQKEEVL---SHMNDVLENELQCIICSEYFIEQRDCSEDRALRAFERL 428
+E E+ ++E+ L L+ E Q + + +QR DR R E+L
Sbjct: 1509 RSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ--LRRQERGQQRRQDRDRKFREEEQL 1563
Score = 37.4 bits (85), Expect = 0.028
Identities = 27/142 (19%), Positives = 74/142 (52%), Gaps = 5/142 (3%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQ- 322
+E+ E ++++ ++ +++ + QE Q+ + + E+ Q + + E+ F +EEQ
Sbjct: 152 EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEE-FPDEEQL 210
Query: 323 -HLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEK 381
+ LE+ + ++ KQQ + Q+ EE + + E +++ + ++L++ + ++++
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDR-VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 382 -MQAQKEEVLSHMNDVLENELQ 402
+Q ++E++ L E Q
Sbjct: 270 ELQEEEEQLRKLERQELRRERQ 291
Score = 37.0 bits (84), Expect = 0.036
Identities = 37/186 (19%), Positives = 82/186 (44%), Gaps = 18/186 (9%)
Query: 231 HHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNV---KKQTQKGNSKKVVQ 287
H E++ A + Q + SRI + + Q++ + +A + + + Q+G ++ Q
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ 735
Query: 288 ------MEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLA 341
E ELQ + + Q Q++ + +Q EE+ +G + L++Q
Sbjct: 736 EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795
Query: 342 QAL-------QEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMN 394
+ L +E L EE + ++ + + + KEL+ +EE++ + ++ + L
Sbjct: 796 RQLRAEERQQREQRFLPEEEEKEQRRRQR--REREKELQFLEEEEQLQRRERAQQLQEEE 853
Query: 395 DVLENE 400
D L+ +
Sbjct: 854 DGLQED 859
Score = 36.2 bits (82), Expect = 0.062
Identities = 38/140 (27%), Positives = 74/140 (52%), Gaps = 15/140 (10%)
Query: 259 LKIQMQEKHEAVMNVKKQTQKGNSKKVVQM---EQELQDLQSQLCAEQA---QQQARVEQ 312
LK++ +E+ E ++Q ++ ++ Q ++E + LQ +L +EQ +Q+ R EQ
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 313 LEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEE--LNRSKKDFEAIIQ--AK 368
L K +EEE+ LE + E+ LK++ + + EE R K++ E ++ K
Sbjct: 549 LLK--REEEKR---LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603
Query: 369 NKELEQTKEEKEKMQAQKEE 388
+E+E+ ++E+ + Q K E
Sbjct: 604 REEVERLEQEERREQRLKRE 623
Score = 36.2 bits (82), Expect = 0.062
Identities = 30/143 (20%), Positives = 70/143 (48%), Gaps = 8/143 (5%)
Query: 260 KIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQE 319
++ QE+ + ++Q ++ + + EQEL+ + + + +QQ +Q ++ F +
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQERDRKFR-EQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535
Query: 320 EEQHLQGLEIAQ---GEKDLK----QQLAQALQEHWALMEELNRSKKDFEAIIQAKNKEL 372
EEQ L+ E Q ++D K +QL Q +E +E +R + E ++ + +E
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595
Query: 373 EQTKEEKEKMQAQKEEVLSHMND 395
+ ++E++ + + ++ L D
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERD 1618
Score = 35.4 bits (80), Expect = 0.11
Identities = 42/172 (24%), Positives = 79/172 (45%), Gaps = 20/172 (11%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKK-QTQKGNSKKVVQMEQE 291
EQ QR Q + R + + QE+ E ++ Q+ KG+ + E++
Sbjct: 153 EQSEKQERLEQRDRQRRD---EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 292 LQDLQ----SQLCAEQAQQQARVEQLEKTFQEEEQH---------LQGLEIAQGEKDLKQ 338
L+ + + E+ QQQ R E+ ++ FQEEE+ + E Q E+ +Q
Sbjct: 210 LRRRELLELRRKGREEKQQQRR-ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 339 QLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEE 388
+ Q +E +E EL R +++ E Q +E + ++++E+ + Q+EE
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Score = 35.4 bits (80), Expect = 0.11
Identities = 34/120 (28%), Positives = 64/120 (53%), Gaps = 23/120 (19%)
Query: 273 VKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQG 332
V++Q Q+ +K ++ EQ+L+ ++ QQQ R E+ ++ F+E+EQ LQ E
Sbjct: 1588 VRRQEQE---RKFMEDEQQLR-------RQEGQQQLRQER-DRKFREDEQLLQERE---- 1632
Query: 333 EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQ----AKNKELEQTKEEKEKMQAQKEE 388
+QQL + ++ L EE +++ E ++ K +E EQ +E E+ Q +++E
Sbjct: 1633 ----EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQE 1688
Score = 35.0 bits (79), Expect = 0.14
Identities = 36/164 (21%), Positives = 76/164 (46%), Gaps = 15/164 (9%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLK-IQMQEKHEAVMNVKKQTQKGNSKKVVQ 287
E HEQK QR + + + R + + E+ +K+ ++ ++ ++
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 288 MEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQL---AQAL 344
+E+E + Q E+ +QQ R EQ EE+ Q L+ + E+ L+Q+L Q
Sbjct: 491 LEEEERREQQ----ERREQQLRREQ-------EERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 345 QEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEE 388
+E E+L + +++ + + + L++ +EE+ ++EE
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583
Score = 35.0 bits (79), Expect = 0.14
Identities = 28/129 (21%), Positives = 63/129 (48%), Gaps = 14/129 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
QE+ E + ++ +K ++ ++ E+E Q L+ Q Q + R E+ + +E+EQ
Sbjct: 1781 QEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ----QRDGKYRWEEEQLQLEEQEQR 1836
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
L + E+D + + +E +A E+ R +++ + K ++ + K +E ++
Sbjct: 1837 L------RQERDRQYR----AEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIR 1886
Query: 384 AQKEEVLSH 392
Q++E H
Sbjct: 1887 RQQKEEQRH 1895
Score = 34.7 bits (78), Expect = 0.18
Identities = 41/176 (23%), Positives = 76/176 (43%), Gaps = 14/176 (7%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+ +H Q Q ++++Q E+E + + + +Q+ + + E+ QEEEQ
Sbjct: 884 RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQL 943
Query: 324 L----------QGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
L + + +K L+Q+ Q L E R KK + + + +E +
Sbjct: 944 LREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK-YREEEELQQEEEQ 1002
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDCSE-DRALRAFERL 428
+EE+EK + Q+ E D L+ E + ++ E E+R E +R R E L
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREER--EKRRLQERERQYREEEEL 1056
Score = 33.9 bits (76), Expect = 0.31
Identities = 39/175 (22%), Positives = 77/175 (44%), Gaps = 23/175 (13%)
Query: 274 KKQTQKGNSKKVVQMEQELQDLQSQLCAEQA------QQQARVEQLEKTFQEEEQHL--- 324
+K+ ++ +K + EQ LQ+ + Q Q +++ R ++ + F EEEQ L
Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQ 1386
Query: 325 ----------QGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQ 374
Q L + E+ L+Q + +E + R +K E Q + +E E+
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER 1446
Query: 375 T-KEEKEKMQAQKEEVLSHMNDVL-ENELQCIICSEYFIEQRDCSEDRALRAFER 427
EE+++++ ++ +L E E Q + E +++ E++ LR ER
Sbjct: 1447 KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER--DRKFLEEEQQLRRQER 1499
Score = 32.7 bits (73), Expect = 0.68
Identities = 40/198 (20%), Positives = 84/198 (42%), Gaps = 36/198 (18%)
Query: 260 KIQMQEKHEAVMNVKKQTQKGN-SKKVVQMEQEL----------QDL------QSQLCAE 302
+++ QE + ++Q + +K +Q EQ+L QD + QL E
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566
Query: 303 QAQQQARVEQLEKTFQEEEQHL-------------QGLEIAQGEKDLKQQLAQALQEHWA 349
+ +QQ ++ ++ F+ EEQ + Q L +G++ L+Q+ + +E
Sbjct: 1567 REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626
Query: 350 LMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEY 409
L++E E + + ++ + +EE + + ++E+ L H D E + ++
Sbjct: 1627 LLQERE------EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE 1680
Query: 410 FIEQRDCSEDRALRAFER 427
+ R DR R E+
Sbjct: 1681 EQQLRRQERDRKFREEEQ 1698
Score = 30.4 bits (67), Expect = 3.4
Identities = 20/79 (25%), Positives = 40/79 (50%), Gaps = 3/79 (3%)
Query: 258 RLKIQMQE---KHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLE 314
+L+++ QE + E + + Q +K + EQEL + Q ++ +++ R E +
Sbjct: 1827 QLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIR 1886
Query: 315 KTFQEEEQHLQGLEIAQGE 333
+ +EE++H Q EI E
Sbjct: 1887 RQQKEEQRHRQVGEIKSQE 1905
Score = 28.9 bits (63), Expect = 9.9
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 263 MQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQ 322
+ E+ A + K+ + ++ Q E +D Q + Q ++Q R EQ + + EEQ
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 323 HLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKM 382
+ + Q ++ + + ++ W +E + + E + K E E+ +E+
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEW---QEREERRAEEEQLQSCKGHETEEFPDEE--- 208
Query: 383 QAQKEEVL 390
Q ++ E+L
Sbjct: 209 QLRRRELL 216
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 51.2 bits (121), Expect = 2e-06
Identities = 49/214 (22%), Positives = 105/214 (49%), Gaps = 24/214 (11%)
Query: 201 DNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKV----TMSRI 256
+++ KLT E K + + T++ HE+ + + LQ K+ M+ +
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 257 LRLKIQMQEKHEAVMNVKKQTQKGNSK---KVVQMEQELQDLQSQLCAEQAQQQARVEQL 313
+K ++ + +++ N K + +K N K ++ +E+ ++L+ QL + ++L
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL 915
Query: 314 EKTFQEEEQ--HLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKE 371
+K+ ++E++ H LE+ +++QL QA L +++K+ E +Q E
Sbjct: 916 KKSLEKEKEASHQLKLEL----NSMQEQLIQA-------QNTLKQNEKE-EQQLQGNINE 963
Query: 372 LEQTKEEKEK-MQAQKEE--VLSHMNDVLENELQ 402
L+Q+ E+K+K ++A + E + LEN+LQ
Sbjct: 964 LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ 997
Score = 45.8 bits (107), Expect = 8e-05
Identities = 47/172 (27%), Positives = 84/172 (48%), Gaps = 30/172 (17%)
Query: 254 SRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARV--- 310
S++L + Q+ E H + K+ ++ +S+K++ EQ++ DLQ +L + Q + +V
Sbjct: 421 SKLLETERQLGEAHGRL----KEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNS 476
Query: 311 ----EQLEKTFQE--EEQHLQGLEIAQ---------------GEKDLK-QQLAQALQEHW 348
QL+KT Q+ E+Q LQ A+ G+KD K Q L LQ+
Sbjct: 477 TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK 536
Query: 349 ALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENE 400
+ L + ++D A IQA E + +EK +E+V + + + L+N+
Sbjct: 537 ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQV-TQLTEKLKNQ 587
Score = 44.7 bits (104), Expect = 2e-04
Identities = 38/180 (21%), Positives = 81/180 (45%), Gaps = 9/180 (5%)
Query: 210 LEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA 269
L+ T + K + H EQ+A S + + L+ + + ++LR Q+ +K +
Sbjct: 469 LKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK-LREAQNDLEQVLR---QIGDKDQK 524
Query: 270 VMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLE- 328
+ N++ QK + + + +E+E +DL +++ A + + + EK +EQ Q E
Sbjct: 525 IQNLEALLQK-SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
Query: 329 ---IAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQ 385
++ K ++ L +QE A + E + N +L ++KE+ ++ Q
Sbjct: 584 LKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQ 643
Score = 41.2 bits (95), Expect = 0.002
Identities = 62/280 (22%), Positives = 113/280 (40%), Gaps = 31/280 (11%)
Query: 145 EKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKV-SCESGQPVKSQGKGEVASTPSDNL 203
E NKE + + L PG E + LK ++ +V + ++ + + E L
Sbjct: 199 ELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKL 258
Query: 204 DPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQM 263
+ + E + + P+ V+ Q+ +S L T++ L K Q
Sbjct: 259 QSQYASSEATISQLRSELAKGPQEVAVY-VQELQKLKSSVNELTQKNQTLTENLLKKEQD 317
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
K E +K ++ SKK +Q +DL Q QL+ E
Sbjct: 318 YTKLE-----EKHNEESVSKKNIQATLHQKDLDCQ-------------QLQSRLSASETS 359
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
L + + EK +A Q+ L EEL+ + ++ + +A+ K+L+Q +EEKE+
Sbjct: 360 LHRIHVELSEK------GEATQK---LKEELSEVETKYQHL-KAEFKQLQQQREEKEQHG 409
Query: 384 AQKEEVLSHMND-VLENELQCIICSEYFIEQRDCSEDRAL 422
Q + ++ ++ +LE E Q EQR S ++ +
Sbjct: 410 LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLM 449
Score = 41.2 bits (95), Expect = 0.002
Identities = 43/202 (21%), Positives = 85/202 (42%), Gaps = 22/202 (10%)
Query: 224 FPKVTEVHHEQKASNSSAS----------QRSLQMFKVTMSRILRLKIQMQEKHEAVMNV 273
+ K+ E H+E+ S + Q+ + + + R+ +++ EK EA +
Sbjct: 318 YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377
Query: 274 KKQTQ---------KGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHL 324
K++ K K++ Q +E + QL +E Q +++ + E+ E L
Sbjct: 378 KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRL 437
Query: 325 QGLEIAQGEK--DLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKM 382
+ EK D +QQ+A LQ + +EE + K +Q + + +Q +E++ +
Sbjct: 438 KEQRQLSSEKLMDKEQQVAD-LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQAL 496
Query: 383 QAQKEEVLSHMNDVLENELQCI 404
Q L + LE L+ I
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQI 518
Score = 39.7 bits (91), Expect = 0.006
Identities = 46/199 (23%), Positives = 82/199 (41%), Gaps = 34/199 (17%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRL-KIQMQEKHEAVMNVKKQTQKGNSKKVVQ 287
E H K +S++ + + L+L +++ Q K + + + Q Q +K Q
Sbjct: 432 EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK---Q 488
Query: 288 MEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEI------------------ 329
QE Q LQ A+ + Q +EQ+ + +++Q +Q LE
Sbjct: 489 QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548
Query: 330 -------AQGEKDLKQQLAQ---ALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEK 379
+GE + QL + LQE + E + K E+ QA+ +Q +E+K
Sbjct: 549 LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTE--KLKNQSESHKQAQENLHDQVQEQK 606
Query: 380 EKMQAQKEEVLSHMNDVLE 398
++A ++ VLS V E
Sbjct: 607 AHLRAAQDRVLSLETSVNE 625
Score = 38.9 bits (89), Expect = 0.010
Identities = 41/174 (23%), Positives = 80/174 (45%), Gaps = 19/174 (10%)
Query: 259 LKIQMQEKHEAVMNVKKQTQKGNSKKVV---QMEQELQDLQSQLCAEQ---AQQQARVEQ 312
LK Q+Q + E + +K+ +K K+ Q++ EL +Q QL Q Q + +Q
Sbjct: 897 LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 313 LEKTFQE----EEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA----- 363
L+ E EQ + +E QGE LK + Q + L ++L ++ ++ A
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGE--LKIAVLQKTELENKLQQQLTQAAQELAAEKEKI 1014
Query: 364 -IIQAKNKELEQT-KEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRD 415
++Q ++ ++T K+ + ++ E+L+ D+ E + + E I R+
Sbjct: 1015 SVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRN 1068
Score = 38.9 bits (89), Expect = 0.010
Identities = 56/296 (18%), Positives = 127/296 (42%), Gaps = 27/296 (9%)
Query: 119 EYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLD-ELAGPGAEGPSNLKSKIN 177
E E T +D +++ LS + +I ++ + K + + A E S K +
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL 1098
Query: 178 KVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKAS 237
+ C++ Q + Q + + N KL +E K ++T+++ E K S
Sbjct: 1099 QERCKALQDI--QKEKSLKEKELVNEKSKLAEIEEIKCRQEK------EITKLNEELK-S 1149
Query: 238 NSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQS 297
+ S + + K +++ K+++Q K +++ +Q ++ Q+++E ++L+
Sbjct: 1150 HKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKK 1209
Query: 298 QLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRS 357
+ ++A+ + +++ E ++ E++ E L Q+ AL E L
Sbjct: 1210 EFIEKEAKLHSEIKEKEVGMKKHEEN---------EAKLTMQIT-------ALNENLGTV 1253
Query: 358 KKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQ 413
KK++++ Q + ELE+ ++ A E + + D L+ + E IE+
Sbjct: 1254 KKEWQS-SQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEK 1308
Score = 37.7 bits (86), Expect = 0.021
Identities = 44/202 (21%), Positives = 88/202 (43%), Gaps = 23/202 (11%)
Query: 228 TEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQ 287
+E H + + + Q + R+L L+ + E + + K++ S+ +Q
Sbjct: 588 SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV----SQLDIQ 643
Query: 288 MEQELQDLQSQLCAEQAQQ---QARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQAL 344
++ + + L S A+ AQ+ Q ++ + Q+++Q L + + K Q
Sbjct: 644 IKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK---LQDK 700
Query: 345 QEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
QEH + +E + K+ ++ K +ELE + +K++A EV + L+ +LQ
Sbjct: 701 QEHCSQLESHLKEYKEKYLSLEQKTEELE---GQIKKLEADSLEVKASKEQALQ-DLQ-- 754
Query: 405 ICSEYFIEQRDCSEDRALRAFE 426
+QR + D LRA E
Sbjct: 755 -------QQRQLNTDLELRATE 769
Score = 37.4 bits (85), Expect = 0.028
Identities = 36/144 (25%), Positives = 72/144 (50%), Gaps = 9/144 (6%)
Query: 285 VVQMEQELQDLQSQLCAEQAQQQARVEQLEK--TFQEEEQHLQGL--EIAQGEKDLKQQL 340
V + QE+QDLQ+ L E+ + ++LEK Q++E GL + + + L+QQL
Sbjct: 85 VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144
Query: 341 AQALQEHWAL--MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+A E++ + M++L K A + + +++ +E+ ++ E+ ++ + + L
Sbjct: 145 EEAQTENFNIKQMKDLFEQK---AAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELN 201
Query: 399 NELQCIICSEYFIEQRDCSEDRAL 422
E I + + QR ED A+
Sbjct: 202 KEATVIQDLKTELLQRPGIEDVAV 225
Score = 37.0 bits (84), Expect = 0.036
Identities = 57/324 (17%), Positives = 144/324 (44%), Gaps = 44/324 (13%)
Query: 113 ENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNL 172
E K+ + ++E ++ + + L+ + + + ++++ +++ + EL S +
Sbjct: 807 EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL--------STV 858
Query: 173 KSKINKVSCESGQPVKSQGKGEVASTPSDNLDPKLTA----------LEPSKTTGAPIYP 222
K K++KVS +S + KS+ + E + LD + T +E + +
Sbjct: 859 KDKLSKVS-DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 223 GFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNS 282
K E H+ K +S ++ +Q L+ + +++ + +N KQ+ +
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQLIQA-----QNTLKQNEKEEQQLQGNINELKQSSEQKK 972
Query: 283 KKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQ 342
K++ ++ EL+ Q + + Q +QL + QE + + + Q + Q+ +
Sbjct: 973 KQIEALQGELKIAVLQKTELENKLQ---QQLTQAAQELAAEKEKISVLQNNYEKSQETFK 1029
Query: 343 ALQ-EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDV-LENE 400
LQ + + EL +++D +++ +EK+ +E+++S+ N + +N+
Sbjct: 1030 QLQSDFYGRESELLATRQDLKSV--------------EEKLSLAQEDLISNRNQIGNQNK 1075
Query: 401 L-QCIICSEYFIEQRDCSEDRALR 423
L Q + ++ +EQ +++ L+
Sbjct: 1076 LIQELKTAKATLEQDSAKKEQQLQ 1099
Score = 36.2 bits (82), Expect = 0.062
Identities = 37/194 (19%), Positives = 87/194 (44%), Gaps = 30/194 (15%)
Query: 231 HHEQKASNS-SASQRSLQMFKVTMSRILRLKIQMQEKH------------EAVMNVKKQT 277
+H A N+ Q+ L + ++ K+Q +++H E ++++++T
Sbjct: 667 NHLDTAQNALQDKQQELNKITTQLDQVTA-KLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 278 Q--KGNSKKV--------VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGL 327
+ +G KK+ EQ LQDLQ Q + R +L K + E++ +
Sbjct: 726 EELEGQIKKLEADSLEVKASKEQALQDLQQQR-QLNTDLELRATELSKQLEMEKEIVSST 784
Query: 328 EI-----AQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKM 382
+ ++ + +KQ+L + +E L ++ ++ + + N ++ T E +K+
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV 844
Query: 383 QAQKEEVLSHMNDV 396
+ +KE +++ ++ V
Sbjct: 845 KMEKEALMTELSTV 858
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 51.2 bits (121), Expect = 2e-06
Identities = 65/282 (23%), Positives = 129/282 (45%), Gaps = 33/282 (11%)
Query: 107 QLGVPLENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELR--TKRKFSLDELAGP 164
+L L++K+ E + E+ + + LS D ++ E+ + +L + A
Sbjct: 365 ELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAAT 424
Query: 165 GAEGPSNLKSKINKVSCESGQP-VKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPG 223
A + L++++ + E GQ K + L +T L+ S
Sbjct: 425 LAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSS---------- 474
Query: 224 FPKVTEVHHE-QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNS 282
+++ E ++AS + ++ + Q+ +T S + L +Q++ + + +K+Q ++
Sbjct: 475 ISNLSQAKEELEQASQAHGARLTAQVASLT-SELTTLNATIQQQDQELAGLKQQAKE--- 530
Query: 283 KKVVQMEQELQDLQSQLCAEQAQQQAR--VEQLEKTFQEEEQHLQGLEIAQGEK----DL 336
K Q+ Q LQ EQA Q R VEQL + +++EQ L+ E+A+ ++ D
Sbjct: 531 -KQAQLAQTLQQ------QEQASQGLRHQVEQLSSSLKQKEQQLK--EVAEKQEATRQDH 581
Query: 337 KQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEE 378
QQLA A +E A + E + + K EA+ + K +LE +++
Sbjct: 582 AQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQ 623
Score = 49.3 bits (116), Expect = 7e-06
Identities = 65/299 (21%), Positives = 133/299 (44%), Gaps = 28/299 (9%)
Query: 139 KNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGEVA-- 196
+ DQ + K+ +++ L + + L+ ++ ++S Q K Q EVA
Sbjct: 516 QQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ--KEQQLKEVAEK 573
Query: 197 --STPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMF----- 249
+T D+ TA E + + K E ++KA+ Q+ LQ+
Sbjct: 574 QEATRQDHAQQLATAAEEREASLRERDAAL-KQLEALEKEKAAKLEILQQQLQVANEARD 632
Query: 250 --KVTMSRILRLKIQMQEKHE---AVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQA 304
+ ++++ R K ++ K E A + +Q Q +V ++E +L+ Q ++A
Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ-----QKA 687
Query: 305 QQQARVEQLEKTFQEEEQHL-QGLEIAQGE-KDLKQQLAQALQEHWALMEELNRSKKDFE 362
++ RV Q + QE+ Q L + L++ +G ++ K++ A AL+E + EL +
Sbjct: 688 TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLV 747
Query: 363 AIIQAKNKELEQTKEEKEKMQA---QKEEVLSHMNDVLENELQCIICSEYFIEQRDCSE 418
+ + KELE+ + ++ ++A Q E +VL EL + +++ E +C +
Sbjct: 748 EQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES-ECEQ 805
Score = 48.9 bits (115), Expect = 9e-06
Identities = 70/281 (24%), Positives = 115/281 (40%), Gaps = 40/281 (14%)
Query: 136 LSPKN-DQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGE 194
L PK +++ +KN+ L + +L + E S + KIN++S E+G K
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTE-KSQMDRKINQLSEENGD---LSFKLR 328
Query: 195 VASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMS 254
++ L L L + K T+ E++A +LQ K
Sbjct: 329 EFASHLQQLQDALNELTEEHS----------KATQEWLEKQAQLEKELSAALQDKKCLEE 378
Query: 255 R--ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ 312
+ IL+ K+ E+H + + +KG V + L+ + L A Q QARVE
Sbjct: 379 KNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEM 438
Query: 313 LEKT--------------FQEEEQHLQGL--EIAQGEKDL---KQQLAQALQEHWALM-- 351
LE F+EE+Q L L ++ +L K++L QA Q H A +
Sbjct: 439 LETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTA 498
Query: 352 --EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVL 390
L A IQ +++EL K++ ++ QAQ + L
Sbjct: 499 QVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTL 539
Score = 45.8 bits (107), Expect = 8e-05
Identities = 37/174 (21%), Positives = 84/174 (48%), Gaps = 9/174 (5%)
Query: 236 ASNSSASQRSLQMFKVTM----SRILRLKIQMQEKHEAVMNVKKQTQKGNS---KKVVQM 288
A+N++ Q ++M + +++L + +E+ + + ++ Q S + ++
Sbjct: 426 AANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEEL 485
Query: 289 EQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHW 348
EQ Q ++L A+ A + + L T Q+++Q L GL+ Q K+ + QLAQ LQ+
Sbjct: 486 EQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLK--QQAKEKQAQLAQTLQQQE 543
Query: 349 ALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQ 402
+ L + + ++ K ++L++ E++E + + L+ + E L+
Sbjct: 544 QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLR 597
Score = 45.1 bits (105), Expect = 1e-04
Identities = 40/163 (24%), Positives = 73/163 (44%), Gaps = 11/163 (6%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQEL 292
+++ +A L++F+ ++ + + + V++Q K + + +QE
Sbjct: 1527 QEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEA 1586
Query: 293 QDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALME 352
Q LQ+QL QAQ L + Q E + +E A+ D K+Q Q LQE +E
Sbjct: 1587 QRLQAQLNELQAQ-------LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE 1639
Query: 353 ELNRSKKDFEAIIQAKNKELEQ----TKEEKEKMQAQKEEVLS 391
+L + K+ A + EL+Q TKE ++ + +V S
Sbjct: 1640 QLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRS 1682
Score = 37.4 bits (85), Expect = 0.028
Identities = 38/151 (25%), Positives = 65/151 (43%), Gaps = 28/151 (18%)
Query: 142 QMIEKNKELRTKRKFSL--DELAGPGAEGPSNLKSKINKV--SCESGQPVKSQGK----- 192
Q+ +++LR KF + D L + L I+ + SCE G P+ K
Sbjct: 1686 QVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQ 1745
Query: 193 -------GEVASTPSDNLDPKLTALE-------PSKTTGAPIYPGFPKVTEVHHEQKASN 238
GE AS S L PK+ +LE P+++ AP+ + +V +
Sbjct: 1746 PDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQ-APLESSLDSLGDVFLDSGRKT 1804
Query: 239 SSASQRSLQMFKVTMSRILRLKIQMQEKHEA 269
SA +R+ Q+ +TM++ K+ ++E A
Sbjct: 1805 RSARRRTTQIINITMTK----KLDVEEPDSA 1831
Score = 35.8 bits (81), Expect = 0.081
Identities = 40/169 (23%), Positives = 77/169 (45%), Gaps = 11/169 (6%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQM 288
EV ++ A + S Q + T + RL+ +++ E ++ K ++ +
Sbjct: 892 EVRAQKLADDLSTLQEKMA---ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQ 948
Query: 289 EQELQDLQS-QLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEH 347
+ L++ Q Q C+ QA QA + E+ E E+ L +QG++ +++ Q +E
Sbjct: 949 PEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQ--QEERGQQEREV 1006
Query: 348 WALMEELNRSKKDFEAIIQAKNKELEQTKE----EKEKMQAQKEEVLSH 392
L +E R++ D A+ +A ELE + E+ A +E L+H
Sbjct: 1007 ARLTQERGRAQADL-ALEKAARAELEMRLQNALNEQRVEFATLQEALAH 1054
Score = 34.7 bits (78), Expect = 0.18
Identities = 44/184 (23%), Positives = 77/184 (41%), Gaps = 31/184 (16%)
Query: 237 SNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQ 296
+ S SQ+ + ++ + + E+ A+ + ++ K+ V E Q+L
Sbjct: 1257 AESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELT 1316
Query: 297 SQL-CAEQAQQQARVEQLEKTFQEEE--------------------------QHLQGLEI 329
SQ AE+ Q+ + Q EK FQ+E+ Q LQ E
Sbjct: 1317 SQAERAEELGQELKAWQ-EKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQA-EQ 1374
Query: 330 AQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK--ELEQTKEEKEKMQAQKE 387
A EK +++L Q+ Q L EL R++++ +I + K E E+T ++ +A
Sbjct: 1375 AAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYA 1434
Query: 388 EVLS 391
E LS
Sbjct: 1435 EQLS 1438
Score = 33.9 bits (76), Expect = 0.31
Identities = 30/146 (20%), Positives = 73/146 (50%), Gaps = 19/146 (13%)
Query: 259 LKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQ-ARVEQLEKT- 316
L++++ + E + + ++ ++++E Q +L A+ + A+V+ LE+
Sbjct: 1465 LEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQ 1524
Query: 317 -FQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE-- 373
FQEE Q L ++ Q E ++Q Q +EEL++ D + + + ++L+
Sbjct: 1525 RFQEERQKLTA-QVEQLEVFQREQTKQ--------VEELSKKLADSDQASKVQQQKLKAV 1575
Query: 374 -----QTKEEKEKMQAQKEEVLSHMN 394
++++E +++QAQ E+ + ++
Sbjct: 1576 QAQGGESQQEAQRLQAQLNELQAQLS 1601
Score = 32.0 bits (71), Expect = 1.2
Identities = 28/103 (27%), Positives = 46/103 (44%), Gaps = 6/103 (5%)
Query: 283 KKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQ 342
++ QM EL+ L++ L Q QQQ E+ QE E E + + DL + A
Sbjct: 972 REAEQMGNELERLRAALMESQGQQQE-----ERGQQEREVARLTQERGRAQADLALEKAA 1026
Query: 343 ALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQ 385
+ L LN + +F + +A L + KE K++ A+
Sbjct: 1027 RAELEMRLQNALNEQRVEFATLQEALAHALTE-KEGKDQELAK 1068
Score = 30.0 bits (66), Expect = 4.4
Identities = 26/104 (25%), Positives = 50/104 (48%), Gaps = 6/104 (5%)
Query: 291 ELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLE-IAQGEKDLKQQLAQALQEH-- 347
E LQ L +++ + ++L K E ++ LE + Q K LK+QLA+ +EH
Sbjct: 1044 EFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS 1103
Query: 348 --WALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
A E R++ ++A E+ + +++ +K Q Q + +
Sbjct: 1104 GSGAQSEAAGRTEPTGPK-LEALRAEVSKLEQQCQKQQEQADSL 1146
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 50.8 bits (120), Expect = 2e-06
Identities = 37/178 (20%), Positives = 87/178 (48%), Gaps = 9/178 (5%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQEL 292
EQ A+ + + + FK + +K ++Q K V ++ + ++ + QE+
Sbjct: 1193 EQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREG-KHSQEI 1251
Query: 293 QDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALME 352
Q++L +AQ Q +QL++ ++ Q +E + E D K++ Q+L++ L E
Sbjct: 1252 AQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTE 1311
Query: 353 ELNRSK--------KDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQ 402
+ R + ++ ++ ++ ++L T+++K +QA+ E+ ++M +L+ Q
Sbjct: 1312 QQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQ 1369
Score = 41.2 bits (95), Expect = 0.002
Identities = 53/194 (27%), Positives = 84/194 (43%), Gaps = 17/194 (8%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQEL 292
E K QR L+ F+ R+ R+ + + VK T +++ ++QE
Sbjct: 661 EAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKL-TLLQRDQQLEALQQEH 719
Query: 293 QDLQSQLCAEQAQQQARVEQLE--KTFQEEEQ----HLQGLEIAQGEKDL------KQQL 340
DL QL Q Q+R + L+ +T +E Q LQG E A E + K L
Sbjct: 720 LDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQG-EAASREDTICLLQNEKIIL 778
Query: 341 AQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENE 400
ALQ + EEL+R + E + ++ LE+ +EE Q E L L+ +
Sbjct: 779 EAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEH-LQQETAALKKQ 837
Query: 401 LQCIICSEYFIEQR 414
+Q I E F++Q+
Sbjct: 838 MQKI--KEQFLQQK 849
Score = 40.0 bits (92), Expect = 0.004
Identities = 52/282 (18%), Positives = 117/282 (41%), Gaps = 35/282 (12%)
Query: 127 EDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKV-----SC 181
++ ET L +QM+ + +K ++EL + + K K+ ++ S
Sbjct: 930 DEMETHLQSLQFDKEQMVAVTEANEALKK-QIEELQQEARKAITEQKQKMRRLGSDLTSA 988
Query: 182 ESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS- 240
+ K + S L L A E + ++ ++ + +S+SS
Sbjct: 989 QKEMKTKHKAYENAVGILSRRLQEALAAKEAADA----------ELGQLRAQGGSSDSSL 1038
Query: 241 ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQS--- 297
A +Q + + + K ++++ + V+ + Q + + +KV+++E ELQ+ +
Sbjct: 1039 ALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRK 1098
Query: 298 ----------QLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEH 347
+L E ++ ++ L ++ +H LE A +++ L Q +
Sbjct: 1099 KIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREA--DLVQLNLQV 1156
Query: 348 WALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
A+++ + + ++QA LE +EKEK+ + KE+V
Sbjct: 1157 QAVLQRKEEEDRQMKHLVQALQASLE---KEKEKVNSLKEQV 1195
Score = 37.4 bits (85), Expect = 0.028
Identities = 41/206 (19%), Positives = 91/206 (44%), Gaps = 33/206 (16%)
Query: 226 KVTEVHHEQKASNSSASQRSLQMFKVTMSRI-LRLKIQMQEKHEAVMNVKKQTQKGNSKK 284
++ +VH E++ + + S+ ++ +V L +Q +K M Q+ + + ++
Sbjct: 886 ELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQ 945
Query: 285 VVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQ--GLEIAQGEKDLKQQ--- 339
+V + + + L+ Q+ E+ QQ+AR K E++Q ++ G ++ +K++K +
Sbjct: 946 MVAVTEANEALKKQI--EELQQEAR-----KAITEQKQKMRRLGSDLTSAQKEMKTKHKA 998
Query: 340 -------LAQALQEHWALMEELNRSKKDFEAI-------------IQAKNKELEQTKEEK 379
L++ LQE A E + A IQA EL+ K
Sbjct: 999 YENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSK 1058
Query: 380 EKMQAQKEEVLSHMNDVLENELQCII 405
++ + +EV++ + LE + ++
Sbjct: 1059 TLLEKELQEVIALTSQELEESREKVL 1084
Score = 37.4 bits (85), Expect = 0.028
Identities = 45/167 (26%), Positives = 83/167 (49%), Gaps = 44/167 (26%)
Query: 259 LKIQMQEKHEAVMNVKKQ---TQKGNSKKVVQMEQELQDLQSQLCAEQAQQ--------- 306
LK ++ +K + ++K+Q T++ K++ ++Q LQ+++S+L E AQ+
Sbjct: 1289 LKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL--EMAQEDLSMTQKDK 1346
Query: 307 ---QARVEQLE---KTFQEEEQHLQGLEIAQGE-KDLKQQLAQALQEHWA---------- 349
QA+V +L+ KT ++ Q L+ L++ +G K K+ +A + A
Sbjct: 1347 FMLQAKVSELKNNMKTLLQQNQQLK-LDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPV 1405
Query: 350 ---LMEELNR-----SKKDFEAIIQAKNKELEQTKEEKEKMQAQKEE 388
L+EEL R SK+ + + N L+Q K+E + +Q Q EE
Sbjct: 1406 PASLLEELLRPPPAVSKEPLKNL----NSCLQQLKQEMDSLQRQMEE 1448
Score = 37.0 bits (84), Expect = 0.036
Identities = 37/154 (24%), Positives = 71/154 (46%), Gaps = 23/154 (14%)
Query: 267 HEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQE------- 319
HE + ++ + Q + K + +E+ELQ++ + E + + +V +LE QE
Sbjct: 1041 HERIQALEAELQAVSHSKTL-LEKELQEVIALTSQELEESREKVLELEDELQESRGFRKK 1099
Query: 320 ----EEQHLQ---GLEIAQGEKDLKQQLAQALQEHWALME--------ELNRSKKDFEAI 364
EE + + LE +G+ Q AL+EH +++E +L + +A+
Sbjct: 1100 IKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAV 1159
Query: 365 IQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+Q K +E Q K + +QA E+ +N + E
Sbjct: 1160 LQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKE 1193
Score = 34.7 bits (78), Expect = 0.18
Identities = 55/282 (19%), Positives = 112/282 (39%), Gaps = 45/282 (15%)
Query: 174 SKINKVSCESGQPVKSQGKGEVASTPS---DNLDPKLTALEPSKTTGAPIYPGFPKVTEV 230
+K K + G +G E + T + L K +E + A + K+ E
Sbjct: 785 AKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQ 844
Query: 231 HHEQKAS------NSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNV--KKQTQKGN- 281
+QK ++++ + + K T R L +++E + +M V +K+T +
Sbjct: 845 FLQQKVMVEAYRRDATSKDQLISELKATRKR---LDSELKELRQELMQVHGEKRTAEAEL 901
Query: 282 ---SKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEK---- 334
++V Q+ Q + DL+ L + Q ++ L+ ++EQ + E + K
Sbjct: 902 SRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIE 961
Query: 335 DLKQQLAQALQEHWALM-----------EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
+L+Q+ +A+ E M +E+ K +E + ++ L++ KE
Sbjct: 962 ELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAAD 1021
Query: 384 AQKEEV------------LSHMNDVLENELQCIICSEYFIEQ 413
A+ ++ L LE ELQ + S+ +E+
Sbjct: 1022 AELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEK 1063
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 50.4 bits (119), Expect = 3e-06
Identities = 51/209 (24%), Positives = 98/209 (46%), Gaps = 30/209 (14%)
Query: 226 KVTEVHHEQKASNSSASQRSLQMFK-VTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKK 284
++++ H E A + LQ K + ++ LK Q++EK + G ++K
Sbjct: 1466 ELSQAHEE--AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIA--------GFTQK 1515
Query: 285 VVQMEQELQDLQSQLCAEQA----------QQQARVEQLEKTFQEEEQHLQGLEIAQGEK 334
VV +E ELQD+ SQ ++A +A+V+ E+ E+ +Q LE Q +
Sbjct: 1516 VVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLE--QAKL 1573
Query: 335 DLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMN 394
L+ ++ + Q H +E+ ++ E Q+ K+L+Q + + E+ K++VL
Sbjct: 1574 RLEMEMERMRQTH---SKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKR 1630
Query: 395 DVLENELQCIICSEYFIEQRDCSEDRALR 423
+ LE +L + + +RD ++ LR
Sbjct: 1631 E-LEGKLATLSDQ---VNRRDFESEKRLR 1655
Score = 45.8 bits (107), Expect = 8e-05
Identities = 70/304 (23%), Positives = 135/304 (44%), Gaps = 46/304 (15%)
Query: 144 IEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINK-------VSCESGQPVKSQGKGEVA 196
+EK ++ R + + + D L +E S L + N + E+ + ++++ + +
Sbjct: 1270 LEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKEL 1329
Query: 197 STPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRI 256
T D L ++ +E I + E++ E ++ R ++ + +
Sbjct: 1330 QTQYDALKKQMEVMEMEVMEARLI-----RAAEINGEVDDDDAGGEWRL--KYERAVREV 1382
Query: 257 LRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKT 316
K ++Q++ E + V++Q ++ Q+E+ L DLQ A+ + Q ++QL+K
Sbjct: 1383 DFTKKRLQQEFEDKLEVEQQNKR-------QLERRLGDLQ----ADSEESQRALQQLKKK 1431
Query: 317 -------FQEEEQHLQGLEIAQGEKDLKQ-----QLAQALQEHWALMEELNRSKKDFEA- 363
Q+ + HL+G ++ E + KQ +L+QA +E A E+L R K E
Sbjct: 1432 CQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE--AQREKLQREKLQREKD 1489
Query: 364 IIQAKNKELEQTKEEKE-KMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDCSEDRAL 422
++ A+ L+Q EEK+ + ++V+S LE ELQ I E E + L
Sbjct: 1490 MLLAEAFSLKQQLEEKDMDIAGFTQKVVS-----LEAELQDISSQESKDEASLAKVKKQL 1544
Query: 423 RAFE 426
R E
Sbjct: 1545 RDLE 1548
Score = 40.0 bits (92), Expect = 0.004
Identities = 38/148 (25%), Positives = 76/148 (51%), Gaps = 37/148 (25%)
Query: 262 QMQEKHEAVM-----------NVKKQTQKGNSKKVVQMEQELQDLQSQL-CAEQA----- 304
++ +KH+A + +++ Q ++ N +K +++++LQ LQSQ+ EQ+
Sbjct: 1757 ELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQ-ELQEKLQALQSQVEFLEQSMVDKS 1815
Query: 305 ---QQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDF 361
+Q+A++ +LE + E ++ LE LA L+E+ ME+L +
Sbjct: 1816 LVSRQEAKIRELETRLEFERTQVKRLE----------SLASRLKEN---MEKLTEER--- 1859
Query: 362 EAIIQAKNKELEQTKEEKEKMQAQKEEV 389
+ I A+N+E EQ K + +++ KEE+
Sbjct: 1860 DQRIAAENREKEQNKRLQRQLRDTKEEM 1887
Score = 38.5 bits (88), Expect = 0.012
Identities = 28/136 (20%), Positives = 66/136 (48%), Gaps = 10/136 (7%)
Query: 281 NSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQL 340
+ +++ Q++ +L++ + A ++A ++E + HLQ +IA+ + L++QL
Sbjct: 1681 SKREIAQLKNQLEESEFTCAAAVKARKAMEVEIE------DLHLQIDDIAKAKTALEEQL 1734
Query: 341 AQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEK---MQAQKEEVLSHMNDVL 397
++ +E + L ++D +++ + Q + + +QAQ EE + L
Sbjct: 1735 SRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQE-L 1793
Query: 398 ENELQCIICSEYFIEQ 413
+ +LQ + F+EQ
Sbjct: 1794 QEKLQALQSQVEFLEQ 1809
Score = 37.4 bits (85), Expect = 0.028
Identities = 28/111 (25%), Positives = 56/111 (50%), Gaps = 9/111 (8%)
Query: 288 MEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEH 347
ME E++DL Q+ + A EQL + +E+ + LE Q + + + +++H
Sbjct: 1709 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQ------EDMNELMKKH 1762
Query: 348 WALMEELNRSK---KDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMND 395
A + + +R D +A ++ NKE ++ +E+ + +Q+Q E + M D
Sbjct: 1763 KAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVD 1813
Score = 37.4 bits (85), Expect = 0.028
Identities = 39/188 (20%), Positives = 90/188 (47%), Gaps = 13/188 (6%)
Query: 227 VTEVHHEQKASNSSASQRSLQM--FKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKK 284
+ E+ + KA+ + AS+ Q+ + + + K ++QEK +A+ + + ++ K
Sbjct: 1755 MNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDK 1814
Query: 285 --VVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHL-----QGLEIAQGEKDLK 337
V + E ++++L+++L E+ Q + R+E L +E + L Q + EK+
Sbjct: 1815 SLVSRQEAKIRELETRLEFERTQVK-RLESLASRLKENMEKLTEERDQRIAAENREKEQN 1873
Query: 338 QQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDV- 396
++L + L++ M EL R + + +LE + + +QA + + D+
Sbjct: 1874 KRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQ 1933
Query: 397 --LENELQ 402
+E+E++
Sbjct: 1934 AAIEDEME 1941
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 50.4 bits (119), Expect = 3e-06
Identities = 51/209 (24%), Positives = 98/209 (46%), Gaps = 30/209 (14%)
Query: 226 KVTEVHHEQKASNSSASQRSLQMFK-VTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKK 284
++++ H E A + LQ K + ++ LK Q++EK + G ++K
Sbjct: 1466 ELSQAHEE--AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIA--------GFTQK 1515
Query: 285 VVQMEQELQDLQSQLCAEQA----------QQQARVEQLEKTFQEEEQHLQGLEIAQGEK 334
VV +E ELQD+ SQ ++A +A+V+ E+ E+ +Q LE Q +
Sbjct: 1516 VVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLE--QAKL 1573
Query: 335 DLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMN 394
L+ ++ + Q H +E+ ++ E Q+ K+L+Q + + E+ K++VL
Sbjct: 1574 RLEMEMERMRQTH---SKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKR 1630
Query: 395 DVLENELQCIICSEYFIEQRDCSEDRALR 423
+ LE +L + + +RD ++ LR
Sbjct: 1631 E-LEGKLATLSDQ---VNRRDFESEKRLR 1655
Score = 45.8 bits (107), Expect = 8e-05
Identities = 70/304 (23%), Positives = 135/304 (44%), Gaps = 46/304 (15%)
Query: 144 IEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINK-------VSCESGQPVKSQGKGEVA 196
+EK ++ R + + + D L +E S L + N + E+ + ++++ + +
Sbjct: 1270 LEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKEL 1329
Query: 197 STPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRI 256
T D L ++ +E I + E++ E ++ R ++ + +
Sbjct: 1330 QTQYDALKKQMEVMEMEVMEARLI-----RAAEINGEVDDDDAGGEWRL--KYERAVREV 1382
Query: 257 LRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKT 316
K ++Q++ E + V++Q ++ Q+E+ L DLQ A+ + Q ++QL+K
Sbjct: 1383 DFTKKRLQQEFEDKLEVEQQNKR-------QLERRLGDLQ----ADSEESQRALQQLKKK 1431
Query: 317 -------FQEEEQHLQGLEIAQGEKDLKQ-----QLAQALQEHWALMEELNRSKKDFEA- 363
Q+ + HL+G ++ E + KQ +L+QA +E A E+L R K E
Sbjct: 1432 CQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE--AQREKLQREKLQREKD 1489
Query: 364 IIQAKNKELEQTKEEKE-KMQAQKEEVLSHMNDVLENELQCIICSEYFIEQRDCSEDRAL 422
++ A+ L+Q EEK+ + ++V+S LE ELQ I E E + L
Sbjct: 1490 MLLAEAFSLKQQLEEKDMDIAGFTQKVVS-----LEAELQDISSQESKDEASLAKVKKQL 1544
Query: 423 RAFE 426
R E
Sbjct: 1545 RDLE 1548
Score = 40.0 bits (92), Expect = 0.004
Identities = 38/148 (25%), Positives = 76/148 (51%), Gaps = 37/148 (25%)
Query: 262 QMQEKHEAVM-----------NVKKQTQKGNSKKVVQMEQELQDLQSQL-CAEQA----- 304
++ +KH+A + +++ Q ++ N +K +++++LQ LQSQ+ EQ+
Sbjct: 1757 ELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQ-ELQEKLQALQSQVEFLEQSMVDKS 1815
Query: 305 ---QQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDF 361
+Q+A++ +LE + E ++ LE LA L+E+ ME+L +
Sbjct: 1816 LVSRQEAKIRELETRLEFERTQVKRLE----------SLASRLKEN---MEKLTEER--- 1859
Query: 362 EAIIQAKNKELEQTKEEKEKMQAQKEEV 389
+ I A+N+E EQ K + +++ KEE+
Sbjct: 1860 DQRIAAENREKEQNKRLQRQLRDTKEEM 1887
Score = 38.5 bits (88), Expect = 0.012
Identities = 28/136 (20%), Positives = 66/136 (48%), Gaps = 10/136 (7%)
Query: 281 NSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQL 340
+ +++ Q++ +L++ + A ++A ++E + HLQ +IA+ + L++QL
Sbjct: 1681 SKREIAQLKNQLEESEFTCAAAVKARKAMEVEIE------DLHLQIDDIAKAKTALEEQL 1734
Query: 341 AQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEK---MQAQKEEVLSHMNDVL 397
++ +E + L ++D +++ + Q + + +QAQ EE + L
Sbjct: 1735 SRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQE-L 1793
Query: 398 ENELQCIICSEYFIEQ 413
+ +LQ + F+EQ
Sbjct: 1794 QEKLQALQSQVEFLEQ 1809
Score = 37.4 bits (85), Expect = 0.028
Identities = 28/111 (25%), Positives = 56/111 (50%), Gaps = 9/111 (8%)
Query: 288 MEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEH 347
ME E++DL Q+ + A EQL + +E+ + LE Q + + + +++H
Sbjct: 1709 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQ------EDMNELMKKH 1762
Query: 348 WALMEELNRSK---KDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMND 395
A + + +R D +A ++ NKE ++ +E+ + +Q+Q E + M D
Sbjct: 1763 KAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVD 1813
Score = 37.4 bits (85), Expect = 0.028
Identities = 39/188 (20%), Positives = 90/188 (47%), Gaps = 13/188 (6%)
Query: 227 VTEVHHEQKASNSSASQRSLQM--FKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKK 284
+ E+ + KA+ + AS+ Q+ + + + K ++QEK +A+ + + ++ K
Sbjct: 1755 MNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDK 1814
Query: 285 --VVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHL-----QGLEIAQGEKDLK 337
V + E ++++L+++L E+ Q + R+E L +E + L Q + EK+
Sbjct: 1815 SLVSRQEAKIRELETRLEFERTQVK-RLESLASRLKENMEKLTEERDQRIAAENREKEQN 1873
Query: 338 QQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDV- 396
++L + L++ M EL R + + +LE + + +QA + + D+
Sbjct: 1874 KRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQ 1933
Query: 397 --LENELQ 402
+E+E++
Sbjct: 1934 AAIEDEME 1941
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 49.3 bits (116), Expect = 7e-06
Identities = 41/191 (21%), Positives = 92/191 (48%), Gaps = 26/191 (13%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVK----------KQTQ 278
E +K + + + R+L+ + + RL Q + + E +M+ K ++++
Sbjct: 1468 EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK 1527
Query: 279 KGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQ 338
+ ++V +M+ +L++L+ +L A + + L+ + E+ LQG + EK K+
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK--KK 1585
Query: 339 QLAQALQEHWALMEELNRSK--------------KDFEAIIQAKNKELEQTKEEKEKMQA 384
QL + ++E A +E+ + + KD EA I + NK ++ ++ K+QA
Sbjct: 1586 QLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQA 1645
Query: 385 QKEEVLSHMND 395
Q ++ + ++D
Sbjct: 1646 QMKDCMRELDD 1656
Score = 47.0 bits (110), Expect = 4e-05
Identities = 70/304 (23%), Positives = 130/304 (42%), Gaps = 35/304 (11%)
Query: 107 QLGVPLENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGA 166
+L LE +E+A + ++ + E L + + ++N +L ++K D +A
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA---- 1002
Query: 167 EGPSNLKSKINKVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPK 226
E +NL + K S K + K E T +L+ +L E +
Sbjct: 1003 EFTTNLTEEEEK----SKSLAKLKNKHEAMIT---DLEERLRREEKQRQ----------- 1044
Query: 227 VTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHE----AVMNVKKQTQKGNS 282
E+ ++ ++ S Q+ ++ ++I LK+Q+ +K E A+ V+++ + N
Sbjct: 1045 --ELEKTRRKLEGDSTDLSDQIAEL-QAQIAELKMQLAKKEEELQAALARVEEEAAQKNM 1101
Query: 283 --KKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQL 340
KK+ ++E ++ +LQ L +E+A + +Q +E E LE +Q+L
Sbjct: 1102 ALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161
Query: 341 -AQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV---LSHMNDV 396
++ QE L + L K EA IQ ++ Q EE + Q + V L
Sbjct: 1162 RSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221
Query: 397 LENE 400
LENE
Sbjct: 1222 LENE 1225
Score = 45.4 bits (106), Expect = 1e-04
Identities = 32/144 (22%), Positives = 71/144 (49%), Gaps = 3/144 (2%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQ--ELQDLQSQLCAEQAQQQARVEQLEKTFQ 318
+Q+ + E +M +++ K K++ + E++ LQSQL AE+ Q Q +++ +
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 319 EEEQHLQGLEIAQGE-KDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKE 377
E E+ L + E +++ L ++E + L KK + IQ ++LE+ +
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957
Query: 378 EKEKMQAQKEEVLSHMNDVLENEL 401
++K+Q +K + + + E ++
Sbjct: 958 ARQKLQLEKVTTEAKLKKLEEEQI 981
Score = 44.7 bits (104), Expect = 2e-04
Identities = 39/180 (21%), Positives = 89/180 (49%), Gaps = 23/180 (12%)
Query: 241 ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK---KVVQMEQELQDLQS 297
A++ L + S+++ K+Q+QE+ +A + + ++ ++ K ++E+ DL++
Sbjct: 863 AAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEA 922
Query: 298 Q----------LCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEH 347
+ L AE+ + Q +++LE+ +EEE Q L++ EK + + L+E
Sbjct: 923 RVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQL---EKVTTEAKLKKLEEE 979
Query: 348 WALMEELN----RSKKDFEAIIQAKNKELEQTKEEKE---KMQAQKEEVLSHMNDVLENE 400
++E+ N + KK E I L + +E+ + K++ + E +++ + + L E
Sbjct: 980 QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Score = 38.9 bits (89), Expect = 0.010
Identities = 60/319 (18%), Positives = 121/319 (37%), Gaps = 62/319 (19%)
Query: 118 AEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRK----------FSLDELAGPGAE 167
A + E+ +D E + D+ I++ ++L+ + K S +E+ E
Sbjct: 1611 ARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKE 1670
Query: 168 GPSNLKSKINKV--------SCESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAP 219
LKS ++ + E + Q + E+A +++ ALE + A
Sbjct: 1671 NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR 1730
Query: 220 IYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILR--------------------L 259
I ++ E + N + +LQ+ ++ L L
Sbjct: 1731 IAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKEL 1790
Query: 260 KIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQE 319
K+++QE V + K + K+ Q+E++L + E ++QA +Q+ +T
Sbjct: 1791 KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDN-------ETKERQAACKQVRRT--- 1840
Query: 320 EEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEK 379
EK LK L Q E + +++ K + Q K ++LE+ +EE
Sbjct: 1841 -------------EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLK-RQLEEAEEEA 1886
Query: 380 EKMQAQKEEVLSHMNDVLE 398
++ A + ++ + D E
Sbjct: 1887 QRANASRRKLQRELEDATE 1905
Score = 36.6 bits (83), Expect = 0.047
Identities = 37/175 (21%), Positives = 73/175 (41%), Gaps = 9/175 (5%)
Query: 231 HHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQ-ME 289
H Q A N Q+ I + +++ EA K+ ++ + + ME
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490
Query: 290 Q--ELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEH 347
Q EL+ L Q E + + + K+ E E+ + LE Q +++K QL + E
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE--QQVEEMKTQLEELEDE- 1547
Query: 348 WALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQ 402
++ +K E +QA + E+ + +++ +K++ L +E EL+
Sbjct: 1548 ---LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE 1599
Score = 35.0 bits (79), Expect = 0.14
Identities = 54/224 (24%), Positives = 95/224 (42%), Gaps = 33/224 (14%)
Query: 206 KLTALEPSKTTGAPIYPGFPKVTEVHHE--QKASNSSASQRSLQMFKVTMSRILRLKIQM 263
K T E +KT A I K ++ E ++ + + +L+ K T+
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN-------- 1224
Query: 264 QEKHEAVMNVKKQTQ-KGNSK-KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKT--FQE 319
E+ E VK Q KG+S+ K ++E +LQ+LQ + ++ R E +K Q
Sbjct: 1225 -ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKF---NEGERVRTELADKVTKLQV 1280
Query: 320 EEQHLQGLEIAQGEKDLK-----QQLAQALQEHWALMEELNRSK----KDFEAIIQAKNK 370
E ++ GL K K L LQ+ L++E NR K + + KN
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340
Query: 371 ELEQTKEEKEKMQAQKEEV------LSHMNDVLENELQCIICSE 408
EQ +EE+E ++++ ++ M +E+ + C+ +E
Sbjct: 1341 FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Score = 34.3 bits (77), Expect = 0.24
Identities = 33/138 (23%), Positives = 68/138 (49%), Gaps = 13/138 (9%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE 321
+++ K E +N+ K+T + +K QE++ SQ E A+Q +EQ ++ E
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ---LEQTKRVKANLE 1216
Query: 322 QHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEK 381
+ Q LE +GE L ++ LQ + ++ KK ++A+ +EL+ E E+
Sbjct: 1217 KAKQTLENERGE--LANEVKVLLQ---GKGDSEHKRKK-----VEAQLQELQVKFNEGER 1266
Query: 382 MQAQKEEVLSHMNDVLEN 399
++ + + ++ + L+N
Sbjct: 1267 VRTELADKVTKLQVELDN 1284
Score = 32.3 bits (72), Expect = 0.89
Identities = 30/126 (23%), Positives = 57/126 (45%), Gaps = 6/126 (4%)
Query: 298 QLCAEQAQQQARVEQLEKTFQEE---EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEEL 354
Q+ ++ + A+ E+L K +++ E L +E Q + L + Q LQE EL
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQ--LMAEKLQ-LQEQLQAETEL 895
Query: 355 NRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQR 414
++ A + AK +ELE+ + E ++EE H+ + Q I E +E+
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955
Query: 415 DCSEDR 420
+ + +
Sbjct: 956 ESARQK 961
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 49.3 bits (116), Expect = 7e-06
Identities = 70/314 (22%), Positives = 130/314 (41%), Gaps = 43/314 (13%)
Query: 136 LSPKNDQMIEKNKELRTK--RKFSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKG 193
L PK K R K R S + GPS S S E P ++
Sbjct: 134 LKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAA 193
Query: 194 EVASTP---SDNLDPKLTALEPSKTTG---APIYPGFPKVTEVHHEQKASNSSASQRSLQ 247
+ TP S P L + PSK A + K+ + K + A + L+
Sbjct: 194 PIIPTPVLTSPGAVPPLPS--PSKEEEGLRAQVRDLEEKLETLR--LKRAEDKAKLKELE 249
Query: 248 MFKVTMSRILRLKIQMQEKH----EAVMNVKKQTQKGNSKKVVQMEQ--------ELQDL 295
K+ + ++ K +MQE+ + +K+ ++ K ME+ E+ L
Sbjct: 250 KHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATL 309
Query: 296 QSQLCAEQAQQ-QARVEQLEKTFQE------------EEQHLQGLEIAQGEKDLKQQLAQ 342
++ E+A+ Q VE L++ E EE+ G + K L++Q A+
Sbjct: 310 DKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNAR 369
Query: 343 ALQEHWALMEELNRSKKD----FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
L++ M +L+ S+K + +++ KN+ELE ++++E++Q + + S + D L+
Sbjct: 370 -LKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTI-DELK 427
Query: 399 NELQCIICSEYFIE 412
++ + +E +E
Sbjct: 428 EQVDAALGAEEMVE 441
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 49.3 bits (116), Expect = 7e-06
Identities = 42/155 (27%), Positives = 80/155 (51%), Gaps = 15/155 (9%)
Query: 257 LRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKT 316
L+ ++QM +K E+ M K+QT N K+V ++ EL + +L E + ++ R QL+KT
Sbjct: 379 LQRELQMLQK-ESSMAEKEQTS--NRKRVEELSLELSEALRKL--ENSDKEKR--QLQKT 431
Query: 317 FQEEEQHLQGL-----EIAQGEKDLKQQLAQALQEHWALMEELN---RSKKDFEAIIQAK 368
E++ + + + + +K +L + LQE L+E+ + K+ E +++ +
Sbjct: 432 VAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGE 491
Query: 369 NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQC 403
+ L Q ++K+K + L N+ L ELQC
Sbjct: 492 LEALRQEFKKKDKTLKENSRKLEEENENLRAELQC 526
Score = 39.3 bits (90), Expect = 0.007
Identities = 41/178 (23%), Positives = 81/178 (45%), Gaps = 22/178 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQ 293
+K NS +R LQ + Q + ++ + +K Q ++ S K ++E++LQ
Sbjct: 416 RKLENSDKEKRQLQK---------TVAEQDMKMNDMLDRIKHQHREQGSIKC-KLEEDLQ 465
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEE 353
+ ++L ++ +Q + ++ EK + E + L+ E + +K LK+ + +E+ L E
Sbjct: 466 EA-TKLLEDKREQLKKSKEHEKLMEGELEALRQ-EFKKKDKTLKENSRKLEEENENLRAE 523
Query: 354 LNRSKKDFEA----------IIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
L E+ +IQ NKE+ KE +QAQ ++ L L+ +
Sbjct: 524 LQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTI 581
Score = 39.3 bits (90), Expect = 0.007
Identities = 32/167 (19%), Positives = 74/167 (44%), Gaps = 7/167 (4%)
Query: 226 KVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV 285
K ++ H + A ++ + T+ R + E A + + + K
Sbjct: 479 KKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKY 538
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+Q +QDL ++ ++ + QL+K Q+E+ +LQ + L ++ A
Sbjct: 539 NTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQD 598
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSH 392
+ +E+LN + +++ Q+ L QT+E+K +++ EE++++
Sbjct: 599 DLTQALEKLNHVTSETKSLQQS----LTQTQEKKAQLE---EEIIAY 638
Score = 38.1 bits (87), Expect = 0.016
Identities = 54/233 (23%), Positives = 98/233 (42%), Gaps = 59/233 (25%)
Query: 223 GFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQ----MQEKHEAVMNV-KKQT 277
G + T H E+K + + Q LQ ++ + +L ++ +QEK E + + KK T
Sbjct: 214 GLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLT 273
Query: 278 QKGNS--KKVVQMEQ------------------------------ELQDLQSQLCAEQAQ 305
Q NS KK ++E+ E+Q L++ L E+A+
Sbjct: 274 QVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSL--EEAK 331
Query: 306 QQARVEQLEKTFQEEEQHLQGLEIAQGEKDLK----------------QQLAQALQEHWA 349
QQ R+ + +EE L G + ++ L+ Q+ Q LQ+ +
Sbjct: 332 QQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESS 391
Query: 350 LME-ELNRSKKDFEAI---IQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+ E E ++K E + + ++LE + +EK ++Q E MND+L+
Sbjct: 392 MAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLD 444
Score = 30.0 bits (66), Expect = 4.4
Identities = 36/198 (18%), Positives = 77/198 (38%), Gaps = 25/198 (12%)
Query: 227 VTEVHHEQKASNSSASQRSLQMFKV-----TMSRILRLKIQMQEKHEAVMNVKKQTQKGN 281
+ E+ ++ SN+ +R + K+ + + R E+ E + + K Q+
Sbjct: 111 IQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQK 170
Query: 282 SKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLA 341
+ + +E E Q+L L E + + K + E L GL
Sbjct: 171 DSQCLHVE-EYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLR------------- 216
Query: 342 QALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKE---EKEKMQAQKEEVLSHMNDVLE 398
+E A +E ++ + +Q E +T++ +K+K +K+E+L + L
Sbjct: 217 ---EETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLT 273
Query: 399 NELQCIICSEYFIEQRDC 416
++ E +E++ C
Sbjct: 274 QVQNSLLKKEKELEKQQC 291
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 49.3 bits (116), Expect = 7e-06
Identities = 42/155 (27%), Positives = 80/155 (51%), Gaps = 15/155 (9%)
Query: 257 LRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKT 316
L+ ++QM +K E+ M K+QT N K+V ++ EL + +L E + ++ R QL+KT
Sbjct: 524 LQRELQMLQK-ESSMAEKEQTS--NRKRVEELSLELSEALRKL--ENSDKEKR--QLQKT 576
Query: 317 FQEEEQHLQGL-----EIAQGEKDLKQQLAQALQEHWALMEELN---RSKKDFEAIIQAK 368
E++ + + + + +K +L + LQE L+E+ + K+ E +++ +
Sbjct: 577 VAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGE 636
Query: 369 NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQC 403
+ L Q ++K+K + L N+ L ELQC
Sbjct: 637 LEALRQEFKKKDKTLKENSRKLEEENENLRAELQC 671
Score = 39.3 bits (90), Expect = 0.007
Identities = 41/178 (23%), Positives = 81/178 (45%), Gaps = 22/178 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQ 293
+K NS +R LQ + Q + ++ + +K Q ++ S K ++E++LQ
Sbjct: 561 RKLENSDKEKRQLQK---------TVAEQDMKMNDMLDRIKHQHREQGSIKC-KLEEDLQ 610
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEE 353
+ ++L ++ +Q + ++ EK + E + L+ E + +K LK+ + +E+ L E
Sbjct: 611 EA-TKLLEDKREQLKKSKEHEKLMEGELEALRQ-EFKKKDKTLKENSRKLEEENENLRAE 668
Query: 354 LNRSKKDFEA----------IIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
L E+ +IQ NKE+ KE +QAQ ++ L L+ +
Sbjct: 669 LQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTI 726
Score = 39.3 bits (90), Expect = 0.007
Identities = 32/167 (19%), Positives = 74/167 (44%), Gaps = 7/167 (4%)
Query: 226 KVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV 285
K ++ H + A ++ + T+ R + E A + + + K
Sbjct: 624 KKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKY 683
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+Q +QDL ++ ++ + QL+K Q+E+ +LQ + L ++ A
Sbjct: 684 NTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQD 743
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSH 392
+ +E+LN + +++ Q+ L QT+E+K +++ EE++++
Sbjct: 744 DLTQALEKLNHVTSETKSLQQS----LTQTQEKKAQLE---EEIIAY 783
Score = 38.1 bits (87), Expect = 0.016
Identities = 54/233 (23%), Positives = 98/233 (42%), Gaps = 59/233 (25%)
Query: 223 GFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQ----MQEKHEAVMNV-KKQT 277
G + T H E+K + + Q LQ ++ + +L ++ +QEK E + + KK T
Sbjct: 359 GLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLT 418
Query: 278 QKGNS--KKVVQMEQ------------------------------ELQDLQSQLCAEQAQ 305
Q NS KK ++E+ E+Q L++ L E+A+
Sbjct: 419 QVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSL--EEAK 476
Query: 306 QQARVEQLEKTFQEEEQHLQGLEIAQGEKDLK----------------QQLAQALQEHWA 349
QQ R+ + +EE L G + ++ L+ Q+ Q LQ+ +
Sbjct: 477 QQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESS 536
Query: 350 LME-ELNRSKKDFEAI---IQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+ E E ++K E + + ++LE + +EK ++Q E MND+L+
Sbjct: 537 MAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLD 589
Score = 30.0 bits (66), Expect = 4.4
Identities = 36/198 (18%), Positives = 77/198 (38%), Gaps = 25/198 (12%)
Query: 227 VTEVHHEQKASNSSASQRSLQMFKV-----TMSRILRLKIQMQEKHEAVMNVKKQTQKGN 281
+ E+ ++ SN+ +R + K+ + + R E+ E + + K Q+
Sbjct: 256 IQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQK 315
Query: 282 SKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLA 341
+ + +E E Q+L L E + + K + E L GL
Sbjct: 316 DSQCLHVE-EYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLR------------- 361
Query: 342 QALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKE---EKEKMQAQKEEVLSHMNDVLE 398
+E A +E ++ + +Q E +T++ +K+K +K+E+L + L
Sbjct: 362 ---EETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLT 418
Query: 399 NELQCIICSEYFIEQRDC 416
++ E +E++ C
Sbjct: 419 QVQNSLLKKEKELEKQQC 436
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 49.3 bits (116), Expect = 7e-06
Identities = 66/318 (20%), Positives = 128/318 (40%), Gaps = 51/318 (16%)
Query: 121 EYEVTEEDWETIYPCLSPKNDQMIEKNKELRT---KRKFSLDELAGPGAEGPSNLKSKIN 177
+YE +E + +S N ++ + + T +R L+E A+ + + +
Sbjct: 1350 QYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE 1409
Query: 178 KVS--CESGQPVKSQGKGEVASTPSD--NLDPKLTALEPSKTTGAPIYPGFP-KVTEVHH 232
V+ C S + K + + EV D + AL+ + I + K E H
Sbjct: 1410 AVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA 1469
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQEL 292
E +AS + S ++FK+ K +E + + +K++ + ++QE+
Sbjct: 1470 ELEASQKESRSLSTELFKI--------KNAYEESLDQLETLKRENKN--------LQQEI 1513
Query: 293 QDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALME 352
DL Q+ A+ R+ +LEK +K+Q+ Q E A +E
Sbjct: 1514 SDLTEQI----AEGGKRIHELEK--------------------IKKQVEQEKSELQAALE 1549
Query: 353 ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIE 412
E S + E I EL Q K E ++ A+K+E + M N ++ + + ++
Sbjct: 1550 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMK---RNHIRIVESMQSTLD 1606
Query: 413 QRDCSEDRALRAFERLPG 430
S + A+R +++ G
Sbjct: 1607 AEIRSRNDAIRLKKKMEG 1624
Score = 37.7 bits (86), Expect = 0.021
Identities = 43/211 (20%), Positives = 92/211 (43%), Gaps = 48/211 (22%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILR-LKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQE 291
EQ+ + S + ++ + R R L+ ++ E+ M+++ Q+ + +K+ + E E
Sbjct: 1032 EQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLD-EKLKKKEFE 1090
Query: 292 LQDLQSQLCAEQA----------QQQARVEQLEKTFQEE------------------EQH 323
+ LQS++ EQA + QAR+E+LE+ + E E+
Sbjct: 1091 MSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1150
Query: 324 LQGLEIAQGE---------------KDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAK 368
+ LE A G + +++ L +A +H A L + D A +
Sbjct: 1151 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL--- 1207
Query: 369 NKELEQTKEEKEKMQAQKEEVLSHMNDVLEN 399
++++ + K+K++ +K E+ ++D+ N
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1238
Score = 35.8 bits (81), Expect = 0.081
Identities = 33/148 (22%), Positives = 74/148 (50%), Gaps = 8/148 (5%)
Query: 244 RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQ 303
RS + K ++ + R +Q + E + +QT++ S+K+ EQEL D ++
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER--SRKIA--EQELLDASERVQLLH 1721
Query: 304 AQQQARVEQLEKTFQEEEQHLQGL--EIAQGEKDLKQQLAQALQEHWALMEELNRSKKDF 361
Q + + +K + + +QG +I Q ++ +++ +A+ + + EEL + ++D
Sbjct: 1722 TQNTSLINT-KKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKK-EQDT 1779
Query: 362 EAIIQAKNKELEQTKEEKEKMQAQKEEV 389
A ++ K LEQT ++ + + E++
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEAEQL 1807
Score = 35.4 bits (80), Expect = 0.11
Identities = 37/180 (20%), Positives = 75/180 (41%), Gaps = 21/180 (11%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQK--GNSKKVV 286
E++ E A ++ K L L +EKH VK T++ G + +
Sbjct: 935 EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIA 994
Query: 287 QMEQE---LQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
++ +E LQ+ Q + ++ +V L K + EQ + LE +
Sbjct: 995 KLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLE-------------GS 1041
Query: 344 LQEHWALMEELNRSKKDFEA---IIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENE 400
L++ + +L R+K+ E + Q ++E K++ ++ +KE +S + +E+E
Sbjct: 1042 LEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDE 1101
Score = 33.5 bits (75), Expect = 0.40
Identities = 35/194 (18%), Positives = 84/194 (43%), Gaps = 29/194 (14%)
Query: 253 MSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ 312
+ ++ R I++ E ++ ++ + +++ + +ME +L +++ QL +
Sbjct: 1587 IDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN 1646
Query: 313 LEKT---FQEEEQHLQGLEIAQGEKDLKQQLAQA----------LQEHWALMEELNRSKK 359
T ++ + HL + + ++DLK+QLA ++E A +E+ RS+K
Sbjct: 1647 YRNTQAILKDTQLHLD--DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1704
Query: 360 DFE----------AIIQAKNKELEQTKEEKE----KMQAQKEEVLSHMNDVLENELQCII 405
E ++ +N L TK++ E ++Q + E+++ + E + I
Sbjct: 1705 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAIT 1764
Query: 406 CSEYFIEQRDCSED 419
+ E+ +D
Sbjct: 1765 DAAMMAEELKKEQD 1778
Score = 31.6 bits (70), Expect = 1.5
Identities = 25/115 (21%), Positives = 52/115 (45%), Gaps = 12/115 (10%)
Query: 279 KGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEK--------TFQEEEQHLQGLEIA 330
KG K++ ++E +++L+ ++ +EQ + V+ L K T+Q EE L +
Sbjct: 1810 KGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRL- 1868
Query: 331 QGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQ 385
+DL +L ++ + EE + + ELE+ +E + ++Q
Sbjct: 1869 ---QDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQ 1920
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 49.3 bits (116), Expect = 7e-06
Identities = 67/325 (20%), Positives = 143/325 (44%), Gaps = 41/325 (12%)
Query: 108 LGVPLENKENAEYEYEVTEEDWETIYPCLSP----KNDQMIEKNKELRTKRKFSLDELAG 163
+G ++ +A+ + E+ E + + + C+S K + EK K RK L+++ G
Sbjct: 1937 IGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQG 1996
Query: 164 PGAE-GPSNLKSKINKVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYP 222
E G + ++ ++ E Q VK K + K++ALE + +
Sbjct: 1997 AQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI------RYQEKISALERTVKALEFVQT 2050
Query: 223 GFPKVTEVHHE---QKASNSSASQRSLQMFKVTM-------SRIL----RLKIQMQEKHE 268
K E+ E Q + +Q L FKV + +R+L +LK ++Q E
Sbjct: 2051 ESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKE 2110
Query: 269 AVMNVKKQTQKGNSKKVVQMEQ----ELQDLQSQLCA---EQAQQQARVEQLEKTFQEEE 321
+V + KQ + +++ Q E+ E +++Q +L A E+ + + +++ T +++
Sbjct: 2111 SVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKD 2170
Query: 322 QHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRS-------KKDFEAIIQAKNKELEQ 374
+ +Q L+ + QLA + +L ++ +R ++ F IQ+K +E+
Sbjct: 2171 KEVQQLQ--ENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL 2228
Query: 375 TKEEKEKMQAQKEEVLSHMNDVLEN 399
++ ++ Q ++ HM ++ N
Sbjct: 2229 KEDNCSVLKDQLRQMSIHMEELKIN 2253
Score = 45.1 bits (105), Expect = 1e-04
Identities = 35/134 (26%), Positives = 65/134 (48%), Gaps = 10/134 (7%)
Query: 275 KQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEK 334
K +G ++ ++ +E++ L+S AE + Q + ++L+K E E LQ E E
Sbjct: 1573 KLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK---EYEILLQSYENVSNEA 1629
Query: 335 DLKQQLAQAL----QEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEE-- 388
+ Q + +A+ QE + + +KK+ E +Q +E+E+ KE+ K K++
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKI 1689
Query: 389 -VLSHMNDVLENEL 401
L ND L E+
Sbjct: 1690 LELEEENDRLRAEV 1703
Score = 43.1 bits (100), Expect = 5e-04
Identities = 61/282 (21%), Positives = 123/282 (43%), Gaps = 52/282 (18%)
Query: 112 LENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSN 171
LE K + E + EE + + ++M++ N+E KFSL G E
Sbjct: 883 LEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEE-----KFSL------GVE-IKT 930
Query: 172 LKSKINKVS-CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEV 230
LK ++N +S E + + + EV+S N D A + SK E+
Sbjct: 931 LKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKE-------------EL 977
Query: 231 HHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKG---NSKKVVQ 287
HE QR ++ ++R L+ ++ E + N+K +++K + + +
Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQ-RVSRLEEELANLKDESKKEIPLSETERGE 1036
Query: 288 MEQELQDLQ-SQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQE 346
+E++ ++ + S+ C Q+ + L++T E+E LQ + KDL+++LA
Sbjct: 1037 VEEDKENKEYSEKCVTSKCQEIEI-YLKQTISEKEVELQHIR-----KDLEEKLA----- 1085
Query: 347 HWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEE 388
+++ F+A+++ N+ L+ + + +QA+ E
Sbjct: 1086 ----------AEEQFQALVKQMNQTLQDKTNQIDLLQAEISE 1117
Score = 42.0 bits (97), Expect = 0.001
Identities = 47/222 (21%), Positives = 91/222 (40%), Gaps = 43/222 (19%)
Query: 226 KVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV 285
++T+ EQ A +S+ M + +K Q+QEK E + ++ Q + +++
Sbjct: 166 QLTQAQAEQPAQSSTE-----------MEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQA 214
Query: 286 VQM----------------EQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQG--- 326
Q E EL L +Q E QQ ++ L++ +E E+ L G
Sbjct: 215 AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQ-KLRVLQRKLEEHEESLVGRAQ 273
Query: 327 -LEIAQGE--------KDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKE 377
+++ Q E + L QQL Q EH L + +++ + +++ E+ + K
Sbjct: 274 VVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKL 333
Query: 378 EKEKMQAQKEEVLSHMNDVLENELQCIICSEY-FIEQRDCSE 418
+Q + +L + Q + S Y +EQ+ +E
Sbjct: 334 SFHNLQEEMHHLLEQFEQA--GQAQAELESRYSALEQKHKAE 373
Score = 42.0 bits (97), Expect = 0.001
Identities = 57/311 (18%), Positives = 136/311 (43%), Gaps = 38/311 (12%)
Query: 96 RVYSIHQGDYIQLGVPLENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRK 155
+ I++ + + + N E++ ++ + + LS + DQ++ + KEL
Sbjct: 702 KAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSM--- 758
Query: 156 FSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGEVASTPSDN-LDPKLTALE-PS 213
+ L++++ ++ + + + + T DN L ++ +L +
Sbjct: 759 -------------VTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEA 805
Query: 214 KTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNV 273
K+ I ++ +V + + S S RSLQ S++ + ++ E E V ++
Sbjct: 806 KSKDVKIEVLQNELDDV--QLQFSEQSTLIRSLQ------SQLQNKESEVLEGAERVRHI 857
Query: 274 KKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGE 333
+ ++ S+ + Q E E+ + L +++ VE L++T +E++Q + + + E
Sbjct: 858 SSKVEE-LSQALSQKELEITKMDQLL----LEKKRDVETLQQTIEEKDQQVTEISFSMTE 912
Query: 334 KDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE--EVLS 391
K + Q +E ++L E+ K+ + +A+ + EQ +E+ E K+ + +S
Sbjct: 913 K-----MVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMS 967
Query: 392 HMNDVLENELQ 402
+ + ELQ
Sbjct: 968 PAGQISKEELQ 978
Score = 40.4 bits (93), Expect = 0.003
Identities = 43/196 (21%), Positives = 88/196 (44%), Gaps = 25/196 (12%)
Query: 226 KVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQE---KHEAVMNVKKQTQKGNS 282
K+ ++ KA +S + + ++ K +L + Q +E KH+ ++ +
Sbjct: 92 KIKKLKLHAKAKLTSLN-KYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIK 150
Query: 283 KKVVQMEQELQDLQSQLCAEQAQQQARVE-------QLEKTFQEEEQHLQGLEIAQGEKD 335
K+ + E+ + LQ+QL QA+Q A+ +++ QE+E+ + L+ +
Sbjct: 151 HKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQ 210
Query: 336 LKQQLAQALQEHWALMEELNR----------SKKDFEAIIQAKNKELEQTKEEKEKMQAQ 385
+Q Q ++E A E R ++ D E +Q K + L++ EE E+
Sbjct: 211 AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVG 270
Query: 386 KEEVLSHMNDVLENEL 401
+ +V+ D+L+ EL
Sbjct: 271 RAQVV----DLLQQEL 282
Score = 39.7 bits (91), Expect = 0.006
Identities = 61/307 (19%), Positives = 123/307 (40%), Gaps = 54/307 (17%)
Query: 141 DQMIEKNKEL------------RTKRKFSLDELAGPGA-----EGPSNLKSKINKVSCES 183
DQ+ +K+KE+ T + S ++ G E ++L+ ++ ++ E
Sbjct: 425 DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEK 484
Query: 184 GQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTG-APIYPGFPKVTEVHHEQKASNSSAS 242
G + S + E ++ L ++T LE TG A + ++ +++ +S +
Sbjct: 485 GALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESG 544
Query: 243 QRSLQM---------------FKVTMSRILRLKIQMQEK------HEAVMNVKKQTQKGN 281
Q L+ K I LK+Q+Q K HE + + + +G
Sbjct: 545 QDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGE 604
Query: 282 SKKVVQMEQELQDL----------QSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQ 331
++M+ L+D +S L A + ++QA E +T +E + G+E+
Sbjct: 605 GIAPIKMKVFLEDTGQDFPLMPNEESSLPAVE-KEQASTEHQSRTSEEISLNDAGVELKS 663
Query: 332 GEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLS 391
++D + L+ +EL R K I + +E EK +K + +S
Sbjct: 664 TKQDGDKSLSAVPDIGQCHQDELERLKSQ----ILELELNFHKAQEIYEKNLDEKAKEIS 719
Query: 392 HMNDVLE 398
++N ++E
Sbjct: 720 NLNQLIE 726
Score = 38.9 bits (89), Expect = 0.010
Identities = 27/128 (21%), Positives = 64/128 (50%), Gaps = 11/128 (8%)
Query: 264 QEKHEAVMNVK--KQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE 321
QEK E ++ + +K K++ + EQE+++++ ++ +Q ++ +LE EE
Sbjct: 1641 QEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE----EEN 1696
Query: 322 QHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEK 381
L+ E+ K+ + L + ++ EEL R K ++E + +K+ + EK+
Sbjct: 1697 DRLRA-EVHPAGDTAKECMETLLSSNASMKEELERVKMEYETL----SKKFQSLMSEKDS 1751
Query: 382 MQAQKEEV 389
+ + +++
Sbjct: 1752 LSEEVQDL 1759
Score = 38.1 bits (87), Expect = 0.016
Identities = 31/160 (19%), Positives = 73/160 (45%), Gaps = 19/160 (11%)
Query: 260 KIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLE----- 314
+ Q+ + + + +Q + S+++ QME E L++ + E+ + + +E++E
Sbjct: 271 RAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAE 330
Query: 315 -----KTFQEEEQHL--QGLEIAQGEKDLKQQLAQALQEHWALMEE-------LNRSKKD 360
QEE HL Q + Q + +L+ + + Q+H A MEE L ++ ++
Sbjct: 331 RKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQE 390
Query: 361 FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENE 400
++ A + + ++K + Q + + + D L+ +
Sbjct: 391 LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK 430
Score = 37.4 bits (85), Expect = 0.028
Identities = 39/142 (27%), Positives = 64/142 (45%), Gaps = 22/142 (15%)
Query: 274 KKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGE 333
K+ K ++K++ ++ +E Q QL + + Q ++ LE+T ++ LE Q E
Sbjct: 1999 KEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERT-------VKALEFVQTE 2051
Query: 334 --KDL---KQQLAQALQEHWALMEELNRSK------KDFEAIIQAKN----KELEQTKEE 378
KDL K+ LAQA++ EL K + A + A N KEL+ KE
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111
Query: 379 KEKMQAQKEEVLSHMNDVLENE 400
+ QK+E L + E +
Sbjct: 2112 VKSQMKQKDEDLERRLEQAEEK 2133
Score = 37.0 bits (84), Expect = 0.036
Identities = 73/350 (20%), Positives = 134/350 (38%), Gaps = 82/350 (23%)
Query: 145 EKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGEVASTPSDNLD 204
EK+KEL+ + + L E SN +I V E+ + K + G++ ST ++
Sbjct: 1606 EKHKELQKEYEILLQSY-----ENVSNEAERIQHV-VEAVRQEKQELYGKLRSTEANK-- 1657
Query: 205 PKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQM---------------- 248
K T + ++ E+ + + S Q+ L++
Sbjct: 1658 ---------KETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
Query: 249 -FKVTMSRILRLKIQMQEKHEAVM----NVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQ 303
K M +L M+E+ E V + K+ Q S+K + +E+QDL+ Q+
Sbjct: 1709 TAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKD-SLSEEVQDLKHQI-EGN 1766
Query: 304 AQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA-------------------- 343
+QA +E EK + +G + GE + + L+ +
Sbjct: 1767 VSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVS 1826
Query: 344 ------------------LQEHWALMEELNRSKKDFEAIIQ-AKNKELEQ--TKEEKEKM 382
L+E A +EE + K+F ++ KN L Q TK+ + KM
Sbjct: 1827 KDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKM 1886
Query: 383 QAQKEEVLSHMNDVLENELQCII-CSEYFIEQRDCSEDRALRAFERLPGS 431
++ ++ +N ++ EL + E E++D E+R + L GS
Sbjct: 1887 LQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGS 1936
Score = 36.2 bits (82), Expect = 0.062
Identities = 36/139 (25%), Positives = 69/139 (49%), Gaps = 15/139 (10%)
Query: 260 KIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARV-----EQLE 314
K +M+EK +++++K Q+ S +Q + LQ + EQA Q A+ +QL+
Sbjct: 371 KAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDK--NEQAVQSAQTIQQLEDQLQ 428
Query: 315 KTFQEEEQHLQGLEIAQGE-------KDLKQQLAQAL-QEHWALMEELNRSKKDFEAIIQ 366
+ +E Q L L + Q E D+ + QA+ +E+ A +++ ++ + +
Sbjct: 429 QKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALL 488
Query: 367 AKNKELEQTKEEKEKMQAQ 385
+ ELE+ K E EK+ +Q
Sbjct: 489 LSSIELEELKAENEKLSSQ 507
Score = 35.4 bits (80), Expect = 0.11
Identities = 33/141 (23%), Positives = 62/141 (43%), Gaps = 9/141 (6%)
Query: 253 MSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ 312
M + LR+ + E+HE + + Q +++ EQ Q L QL +A+
Sbjct: 250 MQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNT 309
Query: 313 LEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKEL 372
+E +E + L+ +E+ E+ L L EE++ + FE QA+ +
Sbjct: 310 VETEREESKILLEKMELEVAERKLSFH---------NLQEEMHHLLEQFEQAGQAQAELE 360
Query: 373 EQTKEEKEKMQAQKEEVLSHM 393
+ ++K +A+ EE SH+
Sbjct: 361 SRYSALEQKHKAEMEEKTSHI 381
Score = 34.3 bits (77), Expect = 0.24
Identities = 55/229 (24%), Positives = 88/229 (38%), Gaps = 50/229 (21%)
Query: 201 DNLDPKLTALEPSKTTGAPIYPGFP----KVTEVHHEQKASNS---------SASQRSLQ 247
+++D KL + + ++ + PG K TE HH Q S S +LQ
Sbjct: 1242 ESIDGKLPSTDQQESCSST--PGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQ 1299
Query: 248 MFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQ 307
+LK EK E + V T + K +E+ LQ Q+ +Q
Sbjct: 1300 GGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS-----EEVFQLQEQI----NKQG 1350
Query: 308 ARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQA 367
+E L+ E E H + L QQ ++ Q A +E L
Sbjct: 1351 LEIESLKTVSHEAEVHAESL----------QQKLESSQLQIAGLEHL------------- 1387
Query: 368 KNKELEQTKEEKEKMQAQKEEVLSHMNDVL-ENELQCIICSEYFIEQRD 415
+EL+ +E +K+ ++KEE +S+++ L E E IEQ D
Sbjct: 1388 --RELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQED 1434
Score = 30.8 bits (68), Expect = 2.6
Identities = 65/334 (19%), Positives = 128/334 (38%), Gaps = 68/334 (20%)
Query: 113 ENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNL 172
E K + E + +E + K +Q +E++ E+ + K + DE++ G L
Sbjct: 919 EEKFSLGVEIKTLKEQLNLLSRAEEAKKEQ-VEEDNEVSSGLKQNYDEMSPAGQISKEEL 977
Query: 173 KSKINKVSCESGQPVKSQ-----GKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKV 227
+ + + + E+ Q + + E+ S L+ +L L+ P+
Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQRVS-RLEEELANLKDESKKEIPLSETERGE 1036
Query: 228 TEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKK--- 284
E E K + Q ++ LK + EK + +++K ++ + +
Sbjct: 1037 VEEDKENKEYSEKCVTSKCQEIEIY------LKQTISEKEVELQHIRKDLEEKLAAEEQF 1090
Query: 285 ---VVQMEQELQDLQSQ---LCAEQAQQQARVEQL------------------------- 313
V QM Q LQD +Q L AE ++ QA +++L
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1150
Query: 314 -----EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALM-----------EELNRS 357
E E E+ + LE + ++ L+++L +AL A++ EEL +
Sbjct: 1151 CTGSSEHWKPELEEKILALE--KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQ 1208
Query: 358 KKDFEAI---IQAKNKELEQTKEEKEKMQAQKEE 388
K D+ + ++KE E ++ ++Q Q E
Sbjct: 1209 KDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRE 1242
Score = 30.8 bits (68), Expect = 2.6
Identities = 29/157 (18%), Positives = 68/157 (43%), Gaps = 15/157 (9%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTF 317
+L+ +Q E + ++ K + + + + +Q + + Q +++LE
Sbjct: 2358 QLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLL 2417
Query: 318 -QEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTK 376
QEEE+++ L+++ +A+ + LME L KK+ IQ K +L+
Sbjct: 2418 SQEEEENIV----------LEEENKKAVDKTNQLMETLKTIKKE---NIQQK-AQLDSFV 2463
Query: 377 EEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEQ 413
+ +Q ++ ++ + E L I+ + I++
Sbjct: 2464 KSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQE 2500
Score = 30.4 bits (67), Expect = 3.4
Identities = 53/286 (18%), Positives = 120/286 (41%), Gaps = 38/286 (13%)
Query: 116 ENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSK 175
++ + + EV + + + + S ++ + +L+ K L+ GAE ++ SK
Sbjct: 806 KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE-----GAERVRHISSK 860
Query: 176 INKVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQK 235
+ ++S ++ + E+ T D L L +T I +VTE+
Sbjct: 861 VEELS-------QALSQKELEITKMDQL--LLEKKRDVETLQQTIEEKDQQVTEI----- 906
Query: 236 ASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDL 295
+ S +++ +Q+ + S + +K ++ +N+ + ++ ++V + + L
Sbjct: 907 --SFSMTEKMVQLNEEKFSLGVEIKTLKEQ-----LNLLSRAEEAKKEQVEEDNEVSSGL 959
Query: 296 QSQLCAEQAQQQARVEQLEKTF----QEEEQHLQGLEIAQ-GEKDLKQQLAQALQEHWAL 350
+ Q E+L+ F +E EQ + L+ A K+L Q++++ L
Sbjct: 960 KQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR-------L 1012
Query: 351 MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDV 396
EEL K + + I E + +E+KE + ++ V S ++
Sbjct: 1013 EEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEI 1058
Score = 30.0 bits (66), Expect = 4.4
Identities = 30/170 (17%), Positives = 75/170 (44%), Gaps = 11/170 (6%)
Query: 246 LQMFKVTMSRILRLKIQMQEKHEA------VMNVKKQTQKGNSKKVVQMEQELQDLQSQL 299
LQ K ++ +L+ +++E EA N ++ ++ SK++ ++ + L Q+
Sbjct: 2559 LQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQV 2618
Query: 300 CAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKK 359
A Q + + + +EEE H + +K ++A+ +E + +E +
Sbjct: 2619 TALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK----RIAELEEELVCVQKEAAKKVG 2674
Query: 360 DFEAIIQAKNKELEQTKE-EKEKMQAQKEEVLSHMNDVLENELQCIICSE 408
+ E ++ + K L + + + +E V D++E E + ++ ++
Sbjct: 2675 EIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTK 2724
Score = 29.6 bits (65), Expect = 5.8
Identities = 44/233 (18%), Positives = 97/233 (41%), Gaps = 20/233 (8%)
Query: 145 EKNKELRTKRKFSLDELAG--PGAEGPSNLKSKINKVSCESGQPVKSQ-GKGEVASTPSD 201
EK+ T+ + DEL A+ + ++ K+ + + + +S G+ +V D
Sbjct: 221 EKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVV----D 276
Query: 202 NLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKI 261
L +LTA E + ++ H+ + + + + S + + + K+
Sbjct: 277 LLQQELTAAEQRNQI---LSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKL 333
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE 321
E + ++ +Q ++ + ++E L+ + AE ++ + + L+KT QE +
Sbjct: 334 SFHNLQEEMHHLLEQFEQAGQAQA-ELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQ 392
Query: 322 QHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQ 374
L+ Q K L+ + QA+Q + + E +Q K+KE+ Q
Sbjct: 393 SACDALK-DQNSKLLQDKNEQAVQSAQTIQQ--------LEDQLQQKSKEISQ 436
Score = 28.9 bits (63), Expect = 9.9
Identities = 35/147 (23%), Positives = 66/147 (44%), Gaps = 18/147 (12%)
Query: 260 KIQMQEKHEAVMNVKKQTQKGNSK-KVVQMEQELQDLQSQLCAEQAQ--QQARVE--QLE 314
K +Q+K + VK + N + ++V Q+L++ + E+ Q Q+A E +L+
Sbjct: 2450 KENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLK 2509
Query: 315 KTFQEEEQHLQGL---------EIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFE--- 362
+ + H+ L E+ Q +DL Q + + L+E + K+ E
Sbjct: 2510 EEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKY 2569
Query: 363 AIIQAKNKELEQTKEE-KEKMQAQKEE 388
A ++ K KE E+ E+ + A +EE
Sbjct: 2570 AKLEEKLKESEEANEDLRRSFNALQEE 2596
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 48.9 bits (115), Expect = 9e-06
Identities = 45/207 (21%), Positives = 97/207 (46%), Gaps = 31/207 (14%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKH----EAVMNVKKQTQKGNSKKVVQMEQ 290
K + A + L+ K+ + ++ K +MQE+ + +K+ ++ K ME+
Sbjct: 103 KRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEE 162
Query: 291 --------ELQDLQSQLCAEQAQQ-QARVEQLEKTFQE------------EEQHLQGLEI 329
E+ L ++ E+A+ Q VE L++ E EE+ G
Sbjct: 163 MADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAAS 222
Query: 330 AQGEKDLKQQLAQALQEHWALMEELNRSKKD----FEAIIQAKNKELEQTKEEKEKMQAQ 385
+ K L++Q A+ L++ M +L+ S+K + +++ KN+ELE ++++E++Q +
Sbjct: 223 SYQLKQLEEQNAR-LKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE 281
Query: 386 KEEVLSHMNDVLENELQCIICSEYFIE 412
+ S + D L+ ++ + +E +E
Sbjct: 282 LSQAESTI-DELKEQVDAALGAEEMVE 307
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 48.9 bits (115), Expect = 9e-06
Identities = 45/207 (21%), Positives = 97/207 (46%), Gaps = 31/207 (14%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKH----EAVMNVKKQTQKGNSKKVVQMEQ 290
K + A + L+ K+ + ++ K +MQE+ + +K+ ++ K ME+
Sbjct: 217 KRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEE 276
Query: 291 --------ELQDLQSQLCAEQAQQ-QARVEQLEKTFQE------------EEQHLQGLEI 329
E+ L ++ E+A+ Q VE L++ E EE+ G
Sbjct: 277 MADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAAS 336
Query: 330 AQGEKDLKQQLAQALQEHWALMEELNRSKKD----FEAIIQAKNKELEQTKEEKEKMQAQ 385
+ K L++Q A+ L++ M +L+ S+K + +++ KN+ELE ++++E++Q +
Sbjct: 337 SYQLKQLEEQNAR-LKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE 395
Query: 386 KEEVLSHMNDVLENELQCIICSEYFIE 412
+ S + D L+ ++ + +E +E
Sbjct: 396 LSQAESTI-DELKEQVDAALGAEEMVE 421
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,524,800
Number of Sequences: 37866
Number of extensions: 847688
Number of successful extensions: 10180
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 265
Number of HSP's successfully gapped in prelim test: 964
Number of HSP's that attempted gapping in prelim test: 4829
Number of HSP's gapped (non-prelim): 4091
length of query: 448
length of database: 18,247,518
effective HSP length: 106
effective length of query: 342
effective length of database: 14,233,722
effective search space: 4867932924
effective search space used: 4867932924
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.