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Search of human proteins with 33469935
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33469935 EGF-like, fibronectin type III and laminin G
domains isoform 3 [Homo sapiens]
(375 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33469935 EGF-like, fibronectin type III and laminin G domains... 774 0.0
gi|33469931 EGF-like, fibronectin type III and laminin G domains... 774 0.0
gi|33469929 EGF-like, fibronectin type III and laminin G domains... 774 0.0
gi|33469937 EGF-like, fibronectin type III and laminin G domains... 313 2e-85
gi|54873613 agrin [Homo sapiens] 206 3e-53
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 196 2e-50
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 112 5e-25
gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens] 110 3e-24
gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens] 102 4e-22
gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens] 100 3e-21
gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens] 98 1e-20
gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens] 98 1e-20
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 89 6e-18
gi|18640734 contactin associated protein-like 5 [Homo sapiens] 86 4e-17
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 86 7e-17
gi|38788416 laminin, alpha 1 precursor [Homo sapiens] 85 1e-16
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 83 5e-16
gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens] 81 2e-15
gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens] 81 2e-15
gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens] 81 2e-15
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi... 79 5e-15
gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1... 78 1e-14
gi|47519929 cell recognition molecule CASPR3 [Homo sapiens] 77 3e-14
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 74 2e-13
gi|239743797 PREDICTED: similar to cell recognition molecule CAS... 74 3e-13
gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sap... 74 3e-13
gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sap... 74 3e-13
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 73 5e-13
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 73 5e-13
gi|219842266 usherin isoform B [Homo sapiens] 69 9e-12
>gi|33469935 EGF-like, fibronectin type III and laminin G domains
isoform 3 [Homo sapiens]
Length = 375
Score = 774 bits (1999), Expect = 0.0
Identities = 375/375 (100%), Positives = 375/375 (100%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 60
MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN
Sbjct: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 60
Query: 61 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP 120
WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP
Sbjct: 61 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP 120
Query: 121 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 180
FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF
Sbjct: 121 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 180
Query: 181 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 240
EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD
Sbjct: 181 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 240
Query: 241 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 300
SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD
Sbjct: 241 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 300
Query: 301 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV 360
DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV
Sbjct: 301 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV 360
Query: 361 EDAVDGKNINTCGAK 375
EDAVDGKNINTCGAK
Sbjct: 361 EDAVDGKNINTCGAK 375
>gi|33469931 EGF-like, fibronectin type III and laminin G domains
isoform 2 [Homo sapiens]
Length = 775
Score = 774 bits (1999), Expect = 0.0
Identities = 375/375 (100%), Positives = 375/375 (100%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 60
MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN
Sbjct: 401 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 460
Query: 61 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP 120
WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP
Sbjct: 461 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP 520
Query: 121 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 180
FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF
Sbjct: 521 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 580
Query: 181 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 240
EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD
Sbjct: 581 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 640
Query: 241 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 300
SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD
Sbjct: 641 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 700
Query: 301 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV 360
DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV
Sbjct: 701 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV 760
Query: 361 EDAVDGKNINTCGAK 375
EDAVDGKNINTCGAK
Sbjct: 761 EDAVDGKNINTCGAK 775
Score = 172 bits (435), Expect = 6e-43
Identities = 117/384 (30%), Positives = 193/384 (50%), Gaps = 28/384 (7%)
Query: 3 FEIT--FRPDSGDGVLLY--SYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 58
F+IT FR ++ DG+LLY + G DF+S+ + ++FRF+CG+G ++ SE + L
Sbjct: 175 FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKL 234
Query: 59 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 118
G WH + + R NG+LQ++ V G ++G +++I T +++GG P+ + + +G
Sbjct: 235 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 294
Query: 119 KPFSGSIQKIILNDRTIHVK----HDFTSGVNV-ENAAHPCVRAPCAHGGSCRPRK-EGY 172
+ F G +Q + +N R I ++ SG +V E ++ C A C HGG+C K + Y
Sbjct: 295 RGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSY 354
Query: 173 DCDCPLGFEGLHCQKAIIEAIEIPQFIG--RSYLTYDNPDILKRVSGSRSNVFMRFKTTA 230
C CPLGF+G HC+ A + IPQF RSY P + FM F+ T
Sbjct: 355 ICLCPLGFKGRHCEDAF--TLTIPQFRESLRSYAATPWP-----LEPQHYLSFMEFEITF 407
Query: 231 K----DGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRV 286
+ DG+LL+ D+ + DF+S+ L G + F ++ GSG + G WH +
Sbjct: 408 RPDSGDGVLLYSYDT---GSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHEL 464
Query: 287 KAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-ALHTNRQYMRGLVGC 345
+ R ++G + VD G + G Q+ N +++GG+ + N ++ G
Sbjct: 465 RVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGS 524
Query: 346 ISHFTLSTDYHISLVEDAVDGKNI 369
I L+ D I + D G N+
Sbjct: 525 IQKIILN-DRTIHVKHDFTSGVNV 547
Score = 95.9 bits (237), Expect = 5e-20
Identities = 78/275 (28%), Positives = 125/275 (45%), Gaps = 23/275 (8%)
Query: 112 KKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAH--PCVRAPCAHGGSCRPRK 169
K S ++ P S S+ + + I ++ +GV + + PC C+ C
Sbjct: 69 KTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVNDY 128
Query: 170 E--GYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFK 227
G C C LG G C + I+ I+ PQF G SY+T++ LK S + + F+
Sbjct: 129 TWGGSRCQCTLGKGGESCSEDIV--IQYPQFFGHSYVTFEP---LKN-SYQAFQITLEFR 182
Query: 228 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVK 287
A+DGLLL+ G++ DF+SL + +L F +N G+GVA I+ G WH V
Sbjct: 183 AEAEDGLLLYCGENE-HGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVM 241
Query: 288 AVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-----ALHTNRQYMRGL 342
RDG +G + +++ TG+S G ++ LY+GG A TN RG
Sbjct: 242 LYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN----RGF 297
Query: 343 VGCISHFTLS---TDYHISLVEDAVDGKNINTCGA 374
GC+ ++ D + A+ G ++ C +
Sbjct: 298 QGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSS 332
>gi|33469929 EGF-like, fibronectin type III and laminin G domains
isoform 1 [Homo sapiens]
Length = 1009
Score = 774 bits (1999), Expect = 0.0
Identities = 375/375 (100%), Positives = 375/375 (100%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 60
MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN
Sbjct: 635 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 694
Query: 61 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP 120
WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP
Sbjct: 695 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP 754
Query: 121 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 180
FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF
Sbjct: 755 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 814
Query: 181 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 240
EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD
Sbjct: 815 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 874
Query: 241 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 300
SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD
Sbjct: 875 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 934
Query: 301 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV 360
DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV
Sbjct: 935 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV 994
Query: 361 EDAVDGKNINTCGAK 375
EDAVDGKNINTCGAK
Sbjct: 995 EDAVDGKNINTCGAK 1009
Score = 172 bits (435), Expect = 6e-43
Identities = 117/384 (30%), Positives = 193/384 (50%), Gaps = 28/384 (7%)
Query: 3 FEIT--FRPDSGDGVLLY--SYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 58
F+IT FR ++ DG+LLY + G DF+S+ + ++FRF+CG+G ++ SE + L
Sbjct: 409 FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKL 468
Query: 59 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 118
G WH + + R NG+LQ++ V G ++G +++I T +++GG P+ + + +G
Sbjct: 469 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 528
Query: 119 KPFSGSIQKIILNDRTIHVK----HDFTSGVNV-ENAAHPCVRAPCAHGGSCRPRK-EGY 172
+ F G +Q + +N R I ++ SG +V E ++ C A C HGG+C K + Y
Sbjct: 529 RGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSY 588
Query: 173 DCDCPLGFEGLHCQKAIIEAIEIPQFIG--RSYLTYDNPDILKRVSGSRSNVFMRFKTTA 230
C CPLGF+G HC+ A + IPQF RSY P + FM F+ T
Sbjct: 589 ICLCPLGFKGRHCEDAF--TLTIPQFRESLRSYAATPWP-----LEPQHYLSFMEFEITF 641
Query: 231 K----DGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRV 286
+ DG+LL+ D+ + DF+S+ L G + F ++ GSG + G WH +
Sbjct: 642 RPDSGDGVLLYSYDT---GSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHEL 698
Query: 287 KAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-ALHTNRQYMRGLVGC 345
+ R ++G + VD G + G Q+ N +++GG+ + N ++ G
Sbjct: 699 RVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGS 758
Query: 346 ISHFTLSTDYHISLVEDAVDGKNI 369
I L+ D I + D G N+
Sbjct: 759 IQKIILN-DRTIHVKHDFTSGVNV 781
Score = 95.9 bits (237), Expect = 5e-20
Identities = 78/275 (28%), Positives = 125/275 (45%), Gaps = 23/275 (8%)
Query: 112 KKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAH--PCVRAPCAHGGSCRPRK 169
K S ++ P S S+ + + I ++ +GV + + PC C+ C
Sbjct: 303 KTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVNDY 362
Query: 170 E--GYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFK 227
G C C LG G C + I+ I+ PQF G SY+T++ LK S + + F+
Sbjct: 363 TWGGSRCQCTLGKGGESCSEDIV--IQYPQFFGHSYVTFEP---LKN-SYQAFQITLEFR 416
Query: 228 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVK 287
A+DGLLL+ G++ DF+SL + +L F +N G+GVA I+ G WH V
Sbjct: 417 AEAEDGLLLYCGENE-HGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVM 475
Query: 288 AVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-----ALHTNRQYMRGL 342
RDG +G + +++ TG+S G ++ LY+GG A TN RG
Sbjct: 476 LYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN----RGF 531
Query: 343 VGCISHFTLS---TDYHISLVEDAVDGKNINTCGA 374
GC+ ++ D + A+ G ++ C +
Sbjct: 532 QGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSS 566
>gi|33469937 EGF-like, fibronectin type III and laminin G domains
isoform 4 [Homo sapiens]
Length = 152
Score = 313 bits (801), Expect = 2e-85
Identities = 152/152 (100%), Positives = 152/152 (100%)
Query: 224 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRW 283
MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRW
Sbjct: 1 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRW 60
Query: 284 HRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLV 343
HRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLV
Sbjct: 61 HRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLV 120
Query: 344 GCISHFTLSTDYHISLVEDAVDGKNINTCGAK 375
GCISHFTLSTDYHISLVEDAVDGKNINTCGAK
Sbjct: 121 GCISHFTLSTDYHISLVEDAVDGKNINTCGAK 152
Score = 56.6 bits (135), Expect = 4e-08
Identities = 37/145 (25%), Positives = 66/145 (45%), Gaps = 5/145 (3%)
Query: 7 FRPDSGDGVLLYSYDTGSK---DFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHE 63
F+ + DG+LL+ D+ + DF+S+ L G + F ++ GSG + G WH
Sbjct: 3 FKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHR 62
Query: 64 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSG 123
++ R ++G + VD G + G Q+ N +++GG+ + N ++ G
Sbjct: 63 VKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-ALHTNRQYMRGLVG 121
Query: 124 SIQKIILN-DRTIHVKHDFTSGVNV 147
I L+ D I + D G N+
Sbjct: 122 CISHFTLSTDYHISLVEDAVDGKNI 146
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 206 bits (524), Expect = 3e-53
Identities = 128/385 (33%), Positives = 198/385 (51%), Gaps = 17/385 (4%)
Query: 1 MEFEITFRPDSGDGVLLYSYDT--GSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 58
M E+ F G+LLY+ G DF+S+ L +EFR+D G G V+RS +P+TL
Sbjct: 1662 MALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTL 1721
Query: 59 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 118
G W + + R + G L+V V G + T + +++GG P++ + + + V
Sbjct: 1722 GAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVS 1781
Query: 119 KPFSGSIQKIILNDRTIHVKHDFTSGVNVEN-AAHPCVRA---PCAHGGSCRPRKEGYDC 174
F G+IQ + L R + V+V + A HPC RA PC +G SC PR+ Y C
Sbjct: 1782 SGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVC 1841
Query: 175 DCPLGFEGLHCQKAIIEA----IEIPQFIGRSYLTYDNPDILKRVSGSRSNVF-MRFKTT 229
CP GF G HC+K ++E ++ F GR+++ Y N + + +SN F + +T
Sbjct: 1842 LCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNA-VTESEKALQSNHFELSLRTE 1900
Query: 230 AKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAV 289
A GL+LW G + R +D+++L + DG L SYNLGS + N RW RV A
Sbjct: 1901 ATQGLVLWSGKATER--ADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAH 1958
Query: 290 RDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIAL--HTNRQYMRGLVGCIS 347
R+ + G + V + TG SP QL+ +GAL++GG+ E+ + + Y G VGC+
Sbjct: 1959 REQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLR 2018
Query: 348 HFTLSTDYHISLVEDAVDGKNINTC 372
+ + + L+EDAV + C
Sbjct: 2019 DVVVGR-HPLHLLEDAVTKPELRPC 2042
Score = 152 bits (383), Expect = 6e-37
Identities = 119/381 (31%), Positives = 165/381 (43%), Gaps = 52/381 (13%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 60
+ + FR G+LLY+ + KDFL++ L G V+ RFD GSG VL S P+ G
Sbjct: 1394 LRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQ 1453
Query: 61 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDD--VKKNSGVL 118
WH L +SR + G L VD + V G + G + +TD+F+GGVP + + V
Sbjct: 1454 WHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVG 1513
Query: 119 KPFSGSIQKIILNDRTIHV---KHDFTSGVNV-ENAAHPCVRAPCAHGGS---------- 164
G I+ + +N++ + + T G V E HPC+ PC HGG+
Sbjct: 1514 AGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPC-HGGAPCQNLEAGRF 1572
Query: 165 -------------------CRPR------------KEGYDCDCPLGFEGLHCQKAIIEAI 193
C+P + G C+CPLG EG CQ A +
Sbjct: 1573 HCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDG 1632
Query: 194 EIP---QFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFI 250
P F G S+L R G + + + F GLLL+ G DF+
Sbjct: 1633 SGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQK-TDGKGDFV 1691
Query: 251 SLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSP 310
SL LRD L F Y+LG G A I G W RV R+G+ G + V D G+SP
Sbjct: 1692 SLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESP 1751
Query: 311 GMMRQLNINGALYVGGMKEIA 331
LN+ LYVGG + +
Sbjct: 1752 VPHTVLNLKEPLYVGGAPDFS 1772
Score = 97.4 bits (241), Expect = 2e-20
Identities = 65/199 (32%), Positives = 100/199 (50%), Gaps = 15/199 (7%)
Query: 153 PCVRAPCAHGGSCRPRK--EGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPD 210
PC PC HGG+C+ G+ C CP G G C+K + +P F GRS+L +
Sbjct: 1332 PCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVL--GAPVPAFEGRSFLAFPT-- 1387
Query: 211 ILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVA 270
L+ R + + F+ GLLL+ G++ DF++L L DG + ++ GSG A
Sbjct: 1388 -LRAYHTLR--LALEFRALEPQGLLLYNGNAR---GKDFLALALLDGRVQLRFDTGSGPA 1441
Query: 271 SIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE- 329
+ G+WHR++ R + G ++VD G+SP LN++ L+VGG+ E
Sbjct: 1442 VLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPED 1501
Query: 330 -IALHTNRQYM-RGLVGCI 346
A+ R ++ GL GCI
Sbjct: 1502 QAAVALERTFVGAGLRGCI 1520
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 196 bits (499), Expect = 2e-50
Identities = 122/411 (29%), Positives = 192/411 (46%), Gaps = 60/411 (14%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGS--KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 58
+ ++ F+P + DGVLL+S +DF+S+ + GGH+EFR++ GSG VLRS +PL L
Sbjct: 3951 LRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLAL 4010
Query: 59 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 118
G WH + R K+G L+V+ + V + G + +T +++GGV + + +
Sbjct: 4011 GRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMS 4070
Query: 119 KPFSGSIQKIILNDRTIHVKHDF--TSGVNVENAAHPCVRAPCAHGGSCRPRKE------ 170
F G + ++ +N + + + + F + G+ + PC R PC HG +C P E
Sbjct: 4071 AHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCL 4130
Query: 171 ------------------------------GYDCDCPLGFEGLHCQKAIIEAI------- 193
G C C GF G CQ+ I
Sbjct: 4131 CRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHL 4190
Query: 194 ------EIPQFIGR-----SYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDS- 241
+ P G +L + + + + + +T+ GLLLW+G
Sbjct: 4191 EGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEV 4250
Query: 242 -PMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 300
DFISLGL+DG LVF Y LGSG A ++ NDG WHRV A+R+G+ G I VD
Sbjct: 4251 GEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVD 4310
Query: 301 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 351
+G+SPG +N G++Y+GG ++A T ++ G+ GC+ + L
Sbjct: 4311 GEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVL 4361
Score = 168 bits (426), Expect = 6e-42
Identities = 129/404 (31%), Positives = 183/404 (45%), Gaps = 67/404 (16%)
Query: 2 EFEITFRPDSGDGVLLYSYDT---GSK--------DFLSINLAGGHVEFRFDCGSGTGVL 50
E +ITFRPDS DG+LLY+ GS DF+S L GG EFRFD GSG +
Sbjct: 3687 EIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATI 3746
Query: 51 RSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDD 110
R PL LG++H + + R+ G L V V G ++G F + N ++++GG P+Y
Sbjct: 3747 RHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPDYGA 3806
Query: 111 VKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSC----- 165
+ K +G+ F G ++++ + I V HD + + C PC +GG C
Sbjct: 3807 IPK-AGLSSGFIGCVRELRIQGEEI-VFHDLNLTAHGISHCPTCRDRPCQNGGQCHDSES 3864
Query: 166 -------------------------------------RPRKEGYDCDCPLGFEGLHCQKA 188
RP GY C C LG GL C++
Sbjct: 3865 SSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEG 3924
Query: 189 IIEAIEIPQFIGR-SYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS 247
+ + P G SYL P + R +V FK A DG+LL+ G P
Sbjct: 3925 V--TVTTPSLSGAGSYLAL--PALTNTHHELRLDV--EFKPLAPDGVLLFSG-GKSGPVE 3977
Query: 248 DFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTG 307
DF+SL + G L F Y LGSG+A + GRWHRV A R + G + V+
Sbjct: 3978 DFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAERLNKDGSLRVNGGRPVLR 4037
Query: 308 KSPGMMRQLNINGALYVGGMK---EIALHTNRQ-YMRGLVGCIS 347
SPG + LN++ LY+GG++ ++ TN + RG VG +S
Sbjct: 4038 SSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVS 4081
Score = 77.0 bits (188), Expect = 3e-14
Identities = 47/167 (28%), Positives = 83/167 (49%), Gaps = 24/167 (14%)
Query: 4 EITFRPDSGDGVLLYS-YDTGS----KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 58
E+ R + G+LL+ + G KDF+S+ L GH+ FR+ GSG L SEDP+
Sbjct: 4231 ELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPIND 4290
Query: 59 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV---KKNS 115
G WH + R + G +QVD +++V G + G + ++IGG P+ + + +S
Sbjct: 4291 GEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSS 4350
Query: 116 GVLKPFSGSIQKIILND--------RTIHVKHDFTSGVNVENAAHPC 154
G+ +G ++ ++L+ + + ++H +G N PC
Sbjct: 4351 GI----TGCVKNLVLHSARPGAPPPQPLDLQHRAQAGAN----TRPC 4389
Score = 63.2 bits (152), Expect = 4e-10
Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 10/160 (6%)
Query: 195 IPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDS--PMRPNS----- 247
+P F Y P I + + + + + F+ + DG+LL+ G P P +
Sbjct: 3663 VPYFTQTPYSFLPLPTI--KDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQ 3720
Query: 248 -DFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGART 306
DFIS GL G F ++ GSG+A+I G +H V +R G + V D
Sbjct: 3721 PDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVN 3780
Query: 307 GKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 346
G S G + L++N LY+GG + G +GC+
Sbjct: 3781 GTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCV 3820
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 112 bits (280), Expect = 5e-25
Identities = 96/397 (24%), Positives = 173/397 (43%), Gaps = 59/397 (14%)
Query: 4 EITFRPDSGDGVLLYSYD---TGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 60
++ F+P + DG+L Y+ S DFL I+L V+ R++ G T +L + +T+
Sbjct: 2721 QLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKVTING 2780
Query: 61 --WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 118
WH ++ R G L +D + E A + + NTD +IGGV + + V +
Sbjct: 2781 STWHIIKAGRVGAEGYLDLDGINVTE-KASTKMSSLDTNTDFYIGGVSSLNLVNPMAIEN 2839
Query: 119 KP--FSGSIQKIILNDRTIHV-KHDFTSGVNVENA-AHPCVRAPCAHGGSCR-------- 166
+P F G I+++I+N++ + + + G NV + C C +GG C
Sbjct: 2840 EPVGFQGCIRQVIINNQELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSC 2899
Query: 167 ------------------------------PRKEGYDCDCPLGFEGLHCQKAIIEAIEIP 196
+ Y C C LG+ G +C+ +
Sbjct: 2900 RCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENK--TSFSTA 2957
Query: 197 QFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRD 256
+F+G SY+ Y +P+ R + + + + F TT +GL++W G + N DF+++GL +
Sbjct: 2958 KFMGNSYIKYIDPNYRMR-NLQFTTISLNFSTTKTEGLIVWMGIAQNEEN-DFLAIGLHN 3015
Query: 257 GALVFSYNLGSGVASIMV--NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMR 314
L + NLG ++ M NG+F +WH V +++ K +++ +
Sbjct: 3016 QTLKIAVNLGERISVPMSYNNGTFCCNKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKN 3075
Query: 315 --QLNINGALYVGGM---KEIALHTNRQYMRGLVGCI 346
LN +G Y+GG +++ + T + VG I
Sbjct: 3076 FVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKI 3112
Score = 100 bits (249), Expect = 2e-21
Identities = 100/406 (24%), Positives = 162/406 (39%), Gaps = 61/406 (15%)
Query: 5 ITFRPDSGDGVLLYSYDTG-SKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHE 63
+T + +S +G +LYS K FL + L G ++ CG+ +L ++
Sbjct: 2177 LTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAF 2236
Query: 64 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDI-----------FIGGVPNYDDVK 112
++ + ++E A+G K +T+I F+G +P +
Sbjct: 2237 TPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIH 2296
Query: 113 KNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHP-CVRAPCAHGGSCRPRKEG 171
K +G + F G I + +N++ + + G N+EN P C C + G+C E
Sbjct: 2297 KKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKNIENCHVPWCAHHLCRNNGTCISDNEN 2356
Query: 172 YDCDCPLGFEGLHCQKAIIE---------------------------------AIEI--P 196
C+CP + G CQ A E AI I P
Sbjct: 2357 LFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQP 2416
Query: 197 QFIGRSYLTYDNPDILKRVSGSRSNVFMRFK-------TTAKDGLLLWRGDSPMRPNSD- 248
+F G Y + R+S + K + ++ L+ + G N D
Sbjct: 2417 RFSGTDAFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDD 2476
Query: 249 FISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGK 308
F+++GL +G++V+SYNLGSG+ASI H V + Q G + VDD+ ++
Sbjct: 2477 FLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHLGKFFQEGWLKVDDHKNKSII 2536
Query: 309 SPGMMRQLNINGALYVGGMKEIA---LHTNRQYMRGLVGCISHFTL 351
+PG + LN+ YVGG E L + G GCI FTL
Sbjct: 2537 APGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCI--FTL 2580
Score = 97.8 bits (242), Expect = 1e-20
Identities = 98/410 (23%), Positives = 168/410 (40%), Gaps = 74/410 (18%)
Query: 26 DFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLG-NWHELRVSRTAKNGILQVDKQKIVE 84
DFL++ L G V + ++ GSG +RSE PL L H + + + + G L+VD K
Sbjct: 2476 DFLAVGLLNGSVVYSYNLGSGIASIRSE-PLNLSLGVHTVHLGKFFQEGWLKVDDHKNKS 2534
Query: 85 GMAEGGFTQIKCNTDIFIGGVPNYD-DVKKNSGVLKP-FSGSIQKI-ILNDRTIHVK--- 138
+A G + + ++GG Y D+ N K F G I + + ++ H +
Sbjct: 2535 IIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLG 2594
Query: 139 ----HDFTSGVNVENAAHPCVRAPCAHGG---------------------------SCRP 167
H + A PC C +GG +C P
Sbjct: 2595 NPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDP 2654
Query: 168 RKE----------------GYDCDCPLGFEGLHCQKAIIEAIEIPQFIGR--SYLTYDNP 209
+ GY C CPLG G++C++A+ +I P F S++++ +
Sbjct: 2655 EHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQAL--SISDPSFRSNELSWMSFASF 2712
Query: 210 DILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG- 268
+ K ++++ ++F+ A DG+L + + DF+ + L + ++ YNLG
Sbjct: 2713 HVRK-----KTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRT 2767
Query: 269 -VASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 327
+ + + N WH +KA R G G + +D T K+ M L+ N Y+GG+
Sbjct: 2768 IILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINV-TEKASTKMSSLDTNTDFYIGGV 2826
Query: 328 KEIALHTNRQYMR----GLVGCISHFTLSTDYHISLVE-DAVDGKNINTC 372
+ L N + G GCI ++ + + L E A G N+ C
Sbjct: 2827 SSLNL-VNPMAIENEPVGFQGCIRQVIIN-NQELQLTEFGAKGGSNVGDC 2874
Score = 61.2 bits (147), Expect = 1e-09
Identities = 73/328 (22%), Positives = 129/328 (39%), Gaps = 61/328 (18%)
Query: 100 IFIGGVPNYDDVKKNSGVLKPFSGSIQKIILND----------RTIHVKH---------- 139
+FIGG P+ + +K F+G I+ I +N+ + H+ +
Sbjct: 2013 VFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQGFMLSP 2072
Query: 140 --------DFTSGVNVE-NAAHPCVRAP-------CAHGGSCRP-----RKEGYDCDCPL 178
D T GV+ + P V AP C +GG+C + CDCPL
Sbjct: 2073 TASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPL 2132
Query: 179 GFEGLHCQKAIIEAIEIPQFIGRSYLTYD-NPDILKRVSGSRSNVFMRFKTTAKDGLLLW 237
F G C+K + P F G SYL +L++ +++ KT + +G +L+
Sbjct: 2133 HFTGRFCEKD--AGLFFPSFNGNSYLELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTILY 2190
Query: 238 RGDSPMRPNSDFISLGLRDGALVFSYNLGS--GVASIMVNGSFNDGRWHRVK---AVRDG 292
+ F+ L L +G Y G+ + ++ N S N + + G
Sbjct: 2191 SNGN--NCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTPVG 2248
Query: 293 QSGKITVDDYGARTGKSPGMMRQLNINGA-------LYVGGM-KEIALHTNRQYMRGLVG 344
G + + + A GK P + I+ A +++G + + +H + G G
Sbjct: 2249 SPGVVCMIEMTA-DGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRG 2307
Query: 345 CISHFTLSTDYHISLVEDAVDGKNINTC 372
CI ++ + ++++A GKNI C
Sbjct: 2308 CILDLQVN-NKEFFIIDEARHGKNIENC 2334
Score = 47.0 bits (110), Expect = 3e-05
Identities = 21/59 (35%), Positives = 27/59 (45%)
Query: 143 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGR 201
+G+N E C+ PC H G C Y CDC GF G HC+ + + P GR
Sbjct: 997 TGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGR 1055
Score = 42.0 bits (97), Expect = 9e-04
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 154 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIE 194
C PC + G C+ G+ C CP G+ G +C+K+I E
Sbjct: 1083 CTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAE 1123
Score = 42.0 bits (97), Expect = 9e-04
Identities = 17/47 (36%), Positives = 22/47 (46%)
Query: 143 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAI 189
SG E + C +PC HG C GY C C G+ G HC+ +
Sbjct: 1154 SGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENEL 1200
Score = 39.3 bits (90), Expect = 0.006
Identities = 36/148 (24%), Positives = 55/148 (37%), Gaps = 35/148 (23%)
Query: 67 SRTAKNGILQVDKQ-----------KIVEG---MAEGGFTQIKCNTDIFIGGVPNYDDVK 112
S KNG +D+ K+V+G + G+ I+C DI DD
Sbjct: 687 SHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDI--------DDCI 738
Query: 113 KNS----GVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPR 168
N+ K S Q + L+D G E ++ C PC + +C
Sbjct: 739 LNACEHNSTCKDLHLSYQCVCLSD---------WEGNFCEQESNECKMNPCKNNSTCTDL 789
Query: 169 KEGYDCDCPLGFEGLHCQKAIIEAIEIP 196
+ Y C+C G+ G +C + I E P
Sbjct: 790 YKSYRCECTSGWTGQNCSEEINECDSDP 817
Score = 36.2 bits (82), Expect = 0.049
Identities = 14/43 (32%), Positives = 24/43 (55%)
Query: 154 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIP 196
C +PC +C R +GY+C C G+ G++C+ + E + P
Sbjct: 970 CKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEP 1012
Score = 34.7 bits (78), Expect = 0.14
Identities = 38/196 (19%), Positives = 83/196 (42%), Gaps = 17/196 (8%)
Query: 186 QKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRP 245
Q+ +I ++ G SYL + N + ++N+ + F+T + GLLL+
Sbjct: 1876 QRLMISDFSCVRYYGDSYLEFQNVAL-----NPQNNISLEFQTFSSYGLLLYVKQDSNLV 1930
Query: 246 NSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHR----VKAVRDGQSGKITVDD 301
+ FI L + +G L + + +N + + ++ D + ++T+
Sbjct: 1931 DGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELTILG 1990
Query: 302 YGARTGKSPG--MMRQLNINGALYVGGMKEIALHTNRQY---MRGLVGCISHFTLSTDYH 356
+ +S + + L +G++++GG + LH Q ++ GCI ++ ++
Sbjct: 1991 RNTQICESINHVLGKPLPKSGSVFIGGFPD--LHGKIQMPVPVKNFTGCIEVIEIN-NWR 2047
Query: 357 ISLVEDAVDGKNINTC 372
+ AV +IN C
Sbjct: 2048 SFIPSKAVKNYHINNC 2063
Score = 31.6 bits (70), Expect = 1.2
Identities = 12/36 (33%), Positives = 19/36 (52%)
Query: 154 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAI 189
C P + +C+ ++ Y C C GF +C+KAI
Sbjct: 374 CESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAI 409
Score = 30.0 bits (66), Expect = 3.5
Identities = 14/41 (34%), Positives = 20/41 (48%), Gaps = 5/41 (12%)
Query: 154 CVRAPCAHGGSCRPRKE-----GYDCDCPLGFEGLHCQKAI 189
C PC + GSC ++E Y+C C F G +C + I
Sbjct: 217 CSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEII 257
Score = 30.0 bits (66), Expect = 3.5
Identities = 16/53 (30%), Positives = 19/53 (35%)
Query: 144 GVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIP 196
G N E C+ C G C + C C GF G C+ I E P
Sbjct: 884 GKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEP 936
Score = 28.9 bits (63), Expect = 7.9
Identities = 15/64 (23%), Positives = 25/64 (39%), Gaps = 14/64 (21%)
Query: 144 GVNVENAAHPCVRAPCAHGGSCRPRK--------------EGYDCDCPLGFEGLHCQKAI 189
G E C PC +G +C + +G+ C C G+ G+ C++ I
Sbjct: 675 GTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDI 734
Query: 190 IEAI 193
+ I
Sbjct: 735 DDCI 738
Score = 28.9 bits (63), Expect = 7.9
Identities = 17/53 (32%), Positives = 25/53 (47%), Gaps = 2/53 (3%)
Query: 146 NVENAAHPCVRAP-CAHGGSCRPRK-EGYDCDCPLGFEGLHCQKAIIEAIEIP 196
+++N A P + + C +GG C +DC C GF G C+ I E P
Sbjct: 1117 SIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSP 1169
>gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
Length = 1642
Score = 110 bits (274), Expect = 3e-24
Identities = 108/406 (26%), Positives = 171/406 (42%), Gaps = 57/406 (14%)
Query: 2 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 60
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
Query: 61 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 119
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
Query: 120 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 171
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
Query: 172 -YDCDCP-LGFEGLHCQK------------AIIEAIE--IPQFIGRSYLTYD---NPDIL 212
CDC GF G C + E E + F G + YD NP
Sbjct: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNP--- 282
Query: 213 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 272
+ S + + F+T ++GL+L G S +D+++L L+ GA+ NLGSG
Sbjct: 283 --IQSSTDEITLAFRTLQRNGLMLHTGKS-----ADYVNLSLKSGAVWLVINLGSGAFEA 335
Query: 273 M---VNGSFNDGRWHRVKAVRDGQSG--------KITVDDYGARTGKSPGMMRQLNINGA 321
+ VNG FND WH V+ R+ + I+VD TG + L +
Sbjct: 336 LVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF 395
Query: 322 LYVGGMKEIALHTNRQYMRGLVGCISHFTL-STDYHISLVEDAVDG 366
Y+GG A +GC+ + D+ + L A +G
Sbjct: 396 FYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEG 441
Score = 87.4 bits (215), Expect = 2e-17
Identities = 77/325 (23%), Positives = 140/325 (43%), Gaps = 39/325 (12%)
Query: 5 ITFRPDSGDGVLLYSYD------TGSK------DFLSINLAGGHVEFRFDCGSGTGVLR- 51
+ FR +G+LL+S GS D+ ++ L GH+ D GSG LR
Sbjct: 488 LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRA 547
Query: 52 SEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV 111
S + G W + R + G + V+ + +A G + +++++GG+P V
Sbjct: 548 SSRKVNDGEWCHVDFQRDGRKGSISVNSRS-TPFLATGDSEILDLESELYLGGLPEGGRV 606
Query: 112 KK-------NSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNV-----ENAAHPCVRA 157
+ + + G ++ + ++ R+ ++ + V V C A
Sbjct: 607 DLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASA 666
Query: 158 PCAHGGSCRPRKEGYDCDC-PLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVS 216
PC +GG CR + CDC GF G C++ + + G Y+ P+ + +
Sbjct: 667 PCRNGGVCREGWNRFICDCIGTGFLGRVCEREAT----VLSYDGSMYMKIMLPNAMHTEA 722
Query: 217 GSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG 276
+V +RF + GL++ + R ++D + L L G + + NLG G ++
Sbjct: 723 ---EDVSLRFMSQRAYGLMM---ATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGH 776
Query: 277 SFNDGRWHRVKAVRDGQSGKITVDD 301
ND WH V+ VR G+S +++VD+
Sbjct: 777 KLNDNEWHTVRVVRRGKSLQLSVDN 801
Score = 86.7 bits (213), Expect = 3e-17
Identities = 84/341 (24%), Positives = 150/341 (43%), Gaps = 26/341 (7%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--SEDPLTL 58
M F+ + DG+LL++ G+ DF+ I L G++ + FD G+G +++ S+ P+
Sbjct: 900 MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVND 958
Query: 59 GNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YDDVKKNS 115
WH + VSR N L++D + + + G + +++IGG+ + ++ K
Sbjct: 959 NQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGELYIGGLSKNMFSNLPKLV 1016
Query: 116 GVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHPCVRAPCAHGGSCRPRKE 170
F G + + LN R + D + + + C CA+ G C + +
Sbjct: 1017 ASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWD 1076
Query: 171 GYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTT 229
G+ CDC + + G C I G + +TY P R S + + F T
Sbjct: 1077 GFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-NDRPSTRMDRLAVGFSTH 1132
Query: 230 AKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI-MVNGSFNDGRWHRVKA 288
+ +L+ R DS D++ L + G + +N+G+ +I N +DG++H V+
Sbjct: 1133 QRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRF 1190
Query: 289 VRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 326
R G + + VD + G RQL N A+ +GG
Sbjct: 1191 TRSGGNATLQVDSWPVNERYPAG--RQLTIFNSQAAIKIGG 1229
Score = 58.5 bits (140), Expect = 9e-09
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 221 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 278
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 901 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 956
Query: 279 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 329
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 957 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1006
Score = 38.9 bits (89), Expect = 0.008
Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 1/94 (1%)
Query: 2 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNW 61
+ + F G+++ + S D L + L GG ++ + G G L + L W
Sbjct: 724 DVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGHKLNDNEW 783
Query: 62 HELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIK 95
H +RV R K+ L VD VEG G +++
Sbjct: 784 HTVRVVRRGKSLQLSVD-NVTVEGQMAGAHMRLE 816
>gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens]
Length = 1477
Score = 102 bits (255), Expect = 4e-22
Identities = 108/402 (26%), Positives = 164/402 (40%), Gaps = 73/402 (18%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDPLT 57
M F++ R S G++LY D G DFL + L GG ++ F C +L ++ P+
Sbjct: 54 MSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLL-ADTPVN 110
Query: 58 LGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 117
G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPP----ELRAAA 166
Query: 118 LK----------PFSGSIQKIILNDRTI------HVKHDF----TSGVNVENAAHPCVRA 157
LK PF G I+ + +N + VK D + G + A
Sbjct: 167 LKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGG 226
Query: 158 PCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAI--IEAIE----------------IPQF 198
C +GG C + CDC GF G C + +E + I F
Sbjct: 227 VCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATF 286
Query: 199 IGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLR 255
G Y YD NP + S + + FKT ++GL+L G S +D+++L L+
Sbjct: 287 KGSEYFCYDLSQNP-----IQSSSDEITLSFKTLQRNGLMLHTGKS-----ADYVNLALK 336
Query: 256 DGALVFSYNLGSGVASIMV---NGSFNDGRWHRVKAVRD--GQSG------KITVDDYGA 304
+GA+ NLGSG +V NG FND WH VK R+ SG I+VD
Sbjct: 337 NGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILT 396
Query: 305 RTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 346
TG + L + YVGG A +GC+
Sbjct: 397 TTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCL 438
Score = 99.0 bits (245), Expect = 6e-21
Identities = 90/344 (26%), Positives = 152/344 (44%), Gaps = 26/344 (7%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--SEDPLTL 58
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S PL
Sbjct: 927 MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLND 985
Query: 59 GNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YDDVKKNS 115
WH + +SR N +++D + + G + +D++IGGV Y + K
Sbjct: 986 NQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLV 1043
Query: 116 GVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGSCRPRKE 170
+ F G + + LN R + D F +G E + C C++ G C + +
Sbjct: 1044 HAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWD 1103
Query: 171 GYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTT 229
G+ CDC + F G C I G +TY P R S + + F T
Sbjct: 1104 GFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLAIGFSTV 1159
Query: 230 AKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGRWHRVKA 288
K+ +L+ R DS D++ L + G + +N+G+ +A N NDG++H V+
Sbjct: 1160 QKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRF 1217
Query: 289 VRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGGMKE 329
R G + + VD + G RQL N + +GG ++
Sbjct: 1218 TRSGGNATLQVDSWPVIERYPAG--RQLTIFNSQATIIIGGKEQ 1259
Score = 96.3 bits (238), Expect = 4e-20
Identities = 89/401 (22%), Positives = 173/401 (43%), Gaps = 68/401 (16%)
Query: 7 FRPDSGDGVLLYSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE- 53
FR +G++L+S+ DF +I + GH+ D GSGT +++
Sbjct: 508 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 567
Query: 54 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 113
+ G W+ + R ++G + V+ + A G + + ++++GG+P +
Sbjct: 568 KKVNDGEWYHVDFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----EN 621
Query: 114 NSGVLKP-----------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCV 155
+G++ P + G I+ + ++ ++ ++ T+GV + A PC+
Sbjct: 622 KAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCL 681
Query: 156 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR 214
PC + G CR Y CDC G+ G C++ + + G ++ P ++
Sbjct: 682 SNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHT 737
Query: 215 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL--------- 265
+ +V +RF++ G+L+ + R ++D + L L G + + NL
Sbjct: 738 EA---EDVSLRFRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNS 791
Query: 266 GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVG 325
G ++ + ND WH V+ VR G+S K+TVDD A TG+ G +L +
Sbjct: 792 SKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI---- 847
Query: 326 GMKEIALHTNRQYMRGL----VGCISHFTLSTDYHISLVED 362
E + T R+Y+ + +G + T + +I L ++
Sbjct: 848 ---ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 885
Score = 43.5 bits (101), Expect = 3e-04
Identities = 30/110 (27%), Positives = 54/110 (49%), Gaps = 5/110 (4%)
Query: 220 SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGL-RDGALVFSYNLGSGV-ASIMVNGS 277
S + + KT + GL+L+ D DF+ L L R G L S+++ A+++ +
Sbjct: 52 SEMSFQLKTRSARGLVLYFDDEGF---CDFLELILTRGGRLQLSFSIFCAEPATLLADTP 108
Query: 278 FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 327
NDG WH V+ R ++ + +D A+ + R + + L+VGG+
Sbjct: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGL 158
>gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens]
Length = 1061
Score = 100 bits (248), Expect = 3e-21
Identities = 91/343 (26%), Positives = 155/343 (45%), Gaps = 30/343 (8%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--SEDPLTL 58
M F+ S DG +L++ G+ DF+++ L G++ + FD G+G V++ S+ PL
Sbjct: 520 MHLFFQFKTTSPDGFILFNSGDGN-DFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLND 578
Query: 59 GNWHELRVSRTAKNG-ILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YDDVKKNS 115
WH + ++R N L+VD + + + + G + D+++ G+ Y ++ K
Sbjct: 579 NQWHNVVITRDNSNTHSLKVDTKVVTQVI--NGAKNLDLKGDLYMAGLAQGMYSNLPKLV 636
Query: 116 GVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGSCRPRKE 170
F G + + LN R + +D SG E + C CA+ G C + E
Sbjct: 637 ASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWE 696
Query: 171 GYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRS--YLTYDNPDILKRVSGSRSNVFMRFK 227
G+ CDC + + G C I G+S + Y P R S + + F
Sbjct: 697 GFTCDCSMTSYSGNQCNDPGATYI-----FGKSGGLILYTWP-ANDRPSTRSDRLAVGFS 750
Query: 228 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS-FNDGRWHRV 286
TT KDG+L+ +P DF+ L + G + +N+G+ SI + NDG++H V
Sbjct: 751 TTVKDGILVRIDSAP--GLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVV 808
Query: 287 KAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 326
+ R+G + + VD++ G RQL N + +GG
Sbjct: 809 RFTRNGGNATLQVDNWPVNEHYPTG--RQLTIFNTQAQIAIGG 849
Score = 81.6 bits (200), Expect = 1e-15
Identities = 76/336 (22%), Positives = 145/336 (43%), Gaps = 57/336 (16%)
Query: 7 FRPDSGDGVLLYSY-------DTGSK-----DFLSINLAGGHVEFRFDCGSGT-GVLRSE 53
FR +G++L+++ D S+ DF ++ L G++ D GSGT V ++
Sbjct: 102 FRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQ 161
Query: 54 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 113
G W+ + + R ++G + V+ ++ A G + D+++GG+P +
Sbjct: 162 KKANDGEWYHVDIQRDGRSGTISVNSRR-TPFTASGESEILDLEGDMYLGGLP-----EN 215
Query: 114 NSGVLKP-----------FSGSIQKIILNDRTIHVKH--DFTSGVNVENA-----AHPCV 155
+G++ P + G I+ + ++ R+ +++ + + V+++ A C
Sbjct: 216 RAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCD 275
Query: 156 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR 214
PC + C+ + CDC G+ G C++ I + G Y+ P ++
Sbjct: 276 SYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREA----SILSYDGSMYMKIIMPMVMHT 331
Query: 215 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL--------- 265
+ +V RF + GLL+ + R ++D + L L G + NL
Sbjct: 332 EA---EDVSFRFMSQRAYGLLV---ATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNS 385
Query: 266 GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDD 301
G ++ ND WH V+ VR G+S K+TVDD
Sbjct: 386 SKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD 421
>gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
Length = 1712
Score = 98.2 bits (243), Expect = 1e-20
Identities = 107/437 (24%), Positives = 170/437 (38%), Gaps = 88/437 (20%)
Query: 2 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 60
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
Query: 61 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 119
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
Query: 120 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 171
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
Query: 172 -YDCDCP-LGFEGLHC--------------------------------------QKAIIE 191
CDC GF G C Q +
Sbjct: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGK 285
Query: 192 AIEIPQFIGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSD 248
+ F G + YD NP + S + + F+T ++GL+L G S +D
Sbjct: 286 EEFVATFKGNEFFCYDLSHNP-----IQSSTDEITLAFRTLQRNGLMLHTGKS-----AD 335
Query: 249 FISLGLRDGALVFSYNLGSGVASIM---VNGSFNDGRWHRVKAVRDGQSG---------- 295
+++L L+ GA+ NLGSG + VNG FND WH V+ R+ +
Sbjct: 336 YVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNK 395
Query: 296 -----KITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFT 350
I+VD TG + L + Y+GG A +GC+
Sbjct: 396 LHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVV 455
Query: 351 L-STDYHISLVEDAVDG 366
+ D+ + L A +G
Sbjct: 456 YKNNDFKLELSRLAKEG 472
Score = 84.0 bits (206), Expect = 2e-16
Identities = 76/314 (24%), Positives = 140/314 (44%), Gaps = 21/314 (6%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--SEDPLTL 58
M F+ + DG+LL++ G+ DF+ I L G++ + FD G+G +++ S+ P+
Sbjct: 940 MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVND 998
Query: 59 GNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YDDVKKNS 115
WH + VSR N L++D + + + G + +++IGG+ + ++ K
Sbjct: 999 NQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGELYIGGLSKNMFSNLPKLV 1056
Query: 116 GVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHPCVRAPCAHGGSCRPRKE 170
F G + + LN R + D + + + C CA+ G C + +
Sbjct: 1057 ASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWD 1116
Query: 171 GYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTT 229
G+ CDC + + G C I G + +TY P R S + + F T
Sbjct: 1117 GFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-NDRPSTRMDRLAVGFSTH 1172
Query: 230 AKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI-MVNGSFNDGRWHRVKA 288
+ +L+ R DS D++ L + G + +N+G+ +I N +DG++H V+
Sbjct: 1173 QRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRF 1230
Query: 289 VRDGQSGKITVDDY 302
R G + + VD +
Sbjct: 1231 TRSGGNATLQVDSW 1244
Score = 77.4 bits (189), Expect = 2e-14
Identities = 76/334 (22%), Positives = 139/334 (41%), Gaps = 48/334 (14%)
Query: 5 ITFRPDSGDGVLLYSYD------TGSK------DFLSINLAGGHVEFRFDCGSGTGVLR- 51
+ FR +G+LL+S GS D+ ++ L GH+ D GSG LR
Sbjct: 519 LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRA 578
Query: 52 SEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV 111
S + G W + R + G + V+ + +A G + +++++GG+P V
Sbjct: 579 SSRKVNDGEWCHVDFQRDGRKGSISVNSRS-TPFLATGDSEILDLESELYLGGLPEGGRV 637
Query: 112 KK-------NSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNV-----ENAAHPCVRA 157
+ + + G ++ + ++ R+ ++ + V V C A
Sbjct: 638 DLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASA 697
Query: 158 PCAHGGSCRPRKEGYDCDC-PLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVS 216
PC +GG CR + CDC GF G C++ + + G Y+ P+ + +
Sbjct: 698 PCRNGGVCREGWNRFICDCIGTGFLGRVCEREAT----VLSYDGSMYMKIMLPNAMHTEA 753
Query: 217 GSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL---------GS 267
+V +RF + GL++ + R ++D + L L G + + NL
Sbjct: 754 ---EDVSLRFMSQRAYGLMM---ATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSK 807
Query: 268 GVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDD 301
G ++ ND WH V+ VR G+S +++VD+
Sbjct: 808 GPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDN 841
Score = 58.5 bits (140), Expect = 9e-09
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 221 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 278
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 941 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 996
Query: 279 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 329
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 997 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1046
Score = 43.9 bits (102), Expect = 2e-04
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 216 SGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV-ASIMV 274
+ S + +T A LLL+ D + DF+ L L DG L + L A++ +
Sbjct: 47 AASSGELSFSLRTNATRALLLYLDDGG---DCDFLELLLVDGRLRLRFTLSCAEPATLQL 103
Query: 275 NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 327
+ D RWH V RD + + VD AR + R++ + L+VGG+
Sbjct: 104 DTPVADDRWHMVLLTRDARRTALAVDG-EARAAEVRSKRREMQVASDLFVGGI 155
Score = 32.0 bits (71), Expect = 0.93
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 5/73 (6%)
Query: 22 TGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL---GNWHELRVSRTAKNGILQVD 78
+G D+L +++ G V F+ G T + ++P + G +H +R +R+ N LQVD
Sbjct: 1185 SGLGDYLQLHIDQGTVGVIFNVG--TDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
Query: 79 KQKIVEGMAEGGF 91
+ E G F
Sbjct: 1243 SWPVNERYPAGNF 1255
>gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens]
Length = 1547
Score = 97.8 bits (242), Expect = 1e-20
Identities = 83/314 (26%), Positives = 141/314 (44%), Gaps = 21/314 (6%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--SEDPLTL 58
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S PL
Sbjct: 967 MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLND 1025
Query: 59 GNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YDDVKKNS 115
WH + +SR N +++D + + G + +D++IGGV Y + K
Sbjct: 1026 NQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLV 1083
Query: 116 GVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGSCRPRKE 170
+ F G + + LN R + D F +G E + C C++ G C + +
Sbjct: 1084 HAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWD 1143
Query: 171 GYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTT 229
G+ CDC + F G C I G +TY P R S + + F T
Sbjct: 1144 GFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLAIGFSTV 1199
Query: 230 AKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGRWHRVKA 288
K+ +L+ R DS D++ L + G + +N+G+ +A N NDG++H V+
Sbjct: 1200 QKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRF 1257
Query: 289 VRDGQSGKITVDDY 302
R G + + VD +
Sbjct: 1258 TRSGGNATLQVDSW 1271
Score = 96.3 bits (238), Expect = 4e-20
Identities = 89/401 (22%), Positives = 173/401 (43%), Gaps = 68/401 (16%)
Query: 7 FRPDSGDGVLLYSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE- 53
FR +G++L+S+ DF +I + GH+ D GSGT +++
Sbjct: 548 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 607
Query: 54 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 113
+ G W+ + R ++G + V+ + A G + + ++++GG+P +
Sbjct: 608 KKVNDGEWYHVDFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----EN 661
Query: 114 NSGVLKP-----------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCV 155
+G++ P + G I+ + ++ ++ ++ T+GV + A PC+
Sbjct: 662 KAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCL 721
Query: 156 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR 214
PC + G CR Y CDC G+ G C++ + + G ++ P ++
Sbjct: 722 SNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHT 777
Query: 215 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL--------- 265
+ +V +RF++ G+L+ + R ++D + L L G + + NL
Sbjct: 778 EA---EDVSLRFRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNS 831
Query: 266 GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVG 325
G ++ + ND WH V+ VR G+S K+TVDD A TG+ G +L +
Sbjct: 832 SKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI---- 887
Query: 326 GMKEIALHTNRQYMRGL----VGCISHFTLSTDYHISLVED 362
E + T R+Y+ + +G + T + +I L ++
Sbjct: 888 ---ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 925
Score = 90.5 bits (223), Expect = 2e-18
Identities = 107/442 (24%), Positives = 164/442 (37%), Gaps = 113/442 (25%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDPLT 57
M F++ R S G++LY D G DFL + L GG ++ F C +L ++ P+
Sbjct: 54 MSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLL-ADTPVN 110
Query: 58 LGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 117
G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPP----ELRAAA 166
Query: 118 LK----------PFSGSIQKIILNDRTI------HVKHDF----TSGVNVENAAHPCVRA 157
LK PF G I+ + +N + VK D + G + A
Sbjct: 167 LKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGG 226
Query: 158 PCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIE---------------------- 194
C +GG C + CDC GF G C + I ++
Sbjct: 227 VCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINTAK 286
Query: 195 -----------------------------IPQFIGRSYLTYD---NPDILKRVSGSRSNV 222
I F G Y YD NP + S +
Sbjct: 287 PLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP-----IQSSSDEI 341
Query: 223 FMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMV---NGSFN 279
+ FKT ++GL+L G S +D+++L L++GA+ NLGSG +V NG FN
Sbjct: 342 TLSFKTLQRNGLMLHTGKS-----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN 396
Query: 280 DGRWHRVKAVRDGQ---------------SGKITVDDYGARTGKSPGMMRQLNINGALYV 324
D WH VK R+ + S I+VD TG + L + YV
Sbjct: 397 DNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYV 456
Query: 325 GGMKEIALHTNRQYMRGLVGCI 346
GG A +GC+
Sbjct: 457 GGSPSTADLPGSPVSNNFMGCL 478
Score = 43.5 bits (101), Expect = 3e-04
Identities = 30/110 (27%), Positives = 54/110 (49%), Gaps = 5/110 (4%)
Query: 220 SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGL-RDGALVFSYNLGSGV-ASIMVNGS 277
S + + KT + GL+L+ D DF+ L L R G L S+++ A+++ +
Sbjct: 52 SEMSFQLKTRSARGLVLYFDDEGF---CDFLELILTRGGRLQLSFSIFCAEPATLLADTP 108
Query: 278 FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 327
NDG WH V+ R ++ + +D A+ + R + + L+VGG+
Sbjct: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGL 158
Score = 34.3 bits (77), Expect = 0.19
Identities = 18/69 (26%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 22 TGSKDFLSINLAGGHVEFRFDCGSGT-GVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQ 80
+G D+L +++ G + +F+ G+ + S + G +H +R +R+ N LQVD
Sbjct: 1212 SGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSW 1271
Query: 81 KIVEGMAEG 89
++E G
Sbjct: 1272 PVIERYPAG 1280
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 89.0 bits (219), Expect = 6e-18
Identities = 72/277 (25%), Positives = 114/277 (41%), Gaps = 41/277 (14%)
Query: 90 GFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVEN 149
GFT C DI KN + + F GS + T G E+
Sbjct: 3891 GFTGRACERDIN----ECLQSPCKNGAICQNFPGSFNCVCKTGYT---------GKMCES 3937
Query: 150 AAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNP 209
+ + C PC +GGSC+ + Y C CP G G HC+ + F SY+ + +
Sbjct: 3938 SVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE------LNSYGFEELSYMEFPSL 3991
Query: 210 DILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV 269
D + + ++++F T LLL+ D+ ++F++L + + L FSYNLGSG
Sbjct: 3992 D------PNNNYIYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSGT 4045
Query: 270 ASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNI----------- 318
+ +DG +H V A R G + +TVD + PG N+
Sbjct: 4046 YKLTTMKKVSDGHFHTVIARRAGMAASLTVD--SCSENQEPGYCTVSNVAVSDDWTLDVQ 4103
Query: 319 NGALYVGGMKEIALHTNRQ---YMRGLVGCISHFTLS 352
+ VGG++ + R+ VGCI F ++
Sbjct: 4104 PNRVTVGGIRSLEPILQRRGHVESHDFVGCIMEFAVN 4140
Score = 78.2 bits (191), Expect = 1e-14
Identities = 82/379 (21%), Positives = 161/379 (42%), Gaps = 47/379 (12%)
Query: 5 ITFRPDSGDGVLLYSYD--TGSK-DFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNW 61
+ F +LLY+YD TG + +FL++ +A + F ++ GSGT L + ++ G++
Sbjct: 4000 VKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSGTYKLTTMKKVSDGHF 4059
Query: 62 HELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTD---------IFIGGVPNYDDVK 112
H + R L VD + + + + D + +GG+ + + +
Sbjct: 4060 HTVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPIL 4119
Query: 113 KNSGVLKP--FSGSIQKIILNDRTIHVKHDFTSGVNVENAAH---PCVRAPCAHGGSCRP 167
+ G ++ F G I + +N R + + ++ C R+PC HGG+C
Sbjct: 4120 QRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSPCQHGGTCMD 4179
Query: 168 RKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR-------VSGSRS 220
C C G G +C+K++ + G+ L Y KR + G+
Sbjct: 4180 YWSWQQCHCKEGLTGKYCEKSVTPDTAL-SLEGKGRLDYHMSQNEKREYLLRQSLRGAML 4238
Query: 221 NVF------MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLG--SGVASI 272
F ++F+T +++G+L+ ++ +S++ ++ +++G + F+ + G V
Sbjct: 4239 EPFGVNSLEVKFRTRSENGVLI-----HIQESSNYTTVKIKNGKVYFTSDAGIAGKVERN 4293
Query: 273 MVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSP----GMMRQLNINGALYVGGMK 328
+ DG WH ++G + ++VD R P G + L I+ +GG+
Sbjct: 4294 IPEVYVADGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDVLTIS----LGGIP 4349
Query: 329 EIALHTNRQYMRGLVGCIS 347
H + Q G GCI+
Sbjct: 4350 PNQAHRDAQ-TAGFDGCIA 4367
Score = 50.8 bits (120), Expect = 2e-06
Identities = 55/229 (24%), Positives = 91/229 (39%), Gaps = 52/229 (22%)
Query: 4 EITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRS--EDPLTLGNW 61
E+ FR S +GVL++ + S ++ ++ + G V F D G V R+ E + G+W
Sbjct: 4247 EVKFRTRSENGVLIHIQE--SSNYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVADGHW 4304
Query: 62 HELRVSRTAKNGILQVDK---QKIVEGMAEGGFTQIKCNTDIFIGGVP-----------N 107
H + + +L VD+ + I+ + G + I +GG+P
Sbjct: 4305 HTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDV---LTISLGGIPPNQAHRDAQTAG 4361
Query: 108 YDDVKKN---SGVLKPFSG--SIQKIILNDRTIHVKHDFTSGVNVENAAHPC-------- 154
+D + G PFSG S+ I D ++ + G N+ A++PC
Sbjct: 4362 FDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIG---CRGPNI-CASNPCWGDLLCIN 4417
Query: 155 -------------VRAPCAHGGSCRP-RKEGYDCDCPLGFEGLHCQKAI 189
PC +GGSC P G+ C CP G C+ +
Sbjct: 4418 QWYAYRCVPPGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEMVV 4466
Score = 45.1 bits (105), Expect = 1e-04
Identities = 17/43 (39%), Positives = 25/43 (58%)
Query: 154 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIP 196
C+ +PC GG+C G+ C CP GF G C++ I E ++ P
Sbjct: 3866 CLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSP 3908
Score = 35.8 bits (81), Expect = 0.064
Identities = 45/174 (25%), Positives = 66/174 (37%), Gaps = 46/174 (26%)
Query: 48 GVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVP- 106
GV +D LT H LR++ + G+ G A ++ + N F+
Sbjct: 3718 GVPTVKDFLTNHYLHFLRIASSQLTGL----------GTAVQLYSAYEENNRTFLLAAVK 3767
Query: 107 -NYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHP-CVRAPCAHGGS 164
N++ SGV F SI++I+L SGV VE+ H CV PC +GGS
Sbjct: 3768 RNHNQYVNPSGVATFFE-SIKEILLRQ----------SGVKVESVDHDSCVHGPCQNGGS 3816
Query: 165 CRPR----------------------KEGYDCDCPLGFEGLHCQKAIIEAIEIP 196
C R + + C C G+ G C+ I E + P
Sbjct: 3817 CLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDECLPSP 3870
>gi|18640734 contactin associated protein-like 5 [Homo sapiens]
Length = 1306
Score = 86.3 bits (212), Expect = 4e-17
Identities = 83/316 (26%), Positives = 139/316 (43%), Gaps = 39/316 (12%)
Query: 7 FRPDSGDGVLLYSYDTGSKDFLSINLAG-GHVEFRFDCGSGTGVLRSEDPLTLGN--WHE 63
F+ + GV L + G KDF+ + ++ + F D G+G L + P L + WH
Sbjct: 819 FKTTALSGVFLENL--GIKDFIRLEISSPSEITFAIDVGNGPVELVVQSPSLLNDNQWHY 876
Query: 64 LRVSRTAKNGILQVDK-QKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFS 122
+R R K LQVD + +E G +++ N+ +F+GG S K F
Sbjct: 877 VRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQLFVGGT---------SSRQKGFL 927
Query: 123 GSIQKIILNDRTIHVKH--DFTSGVNVENAAH-PCVRAPCAHGGSCRPRKEGYDCDCPLG 179
G I+ + LN + + ++ TSGV H + C +GG C + GY CDC
Sbjct: 928 GCIRSLHLNGQKMDLEERAKVTSGVRPGCPGHCSSYGSICHNGGKCVEKHNGYLCDCTNS 987
Query: 180 -FEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVS-----------GSRSNVFMRFK 227
+EG C+K + E + +Y+ + + K +S S+ N+ + F
Sbjct: 988 PYEGPFCKKEVSAVFEAGTSV--TYMFQEPYPVTKNISLSSSAIYTDSAPSKENIALSFV 1045
Query: 228 TTAKDGLLLWRGDSPMRPNSDFISLGL-RDGALVFSYNLGSGVASIMV--NGSFNDGRWH 284
TT LLL+ S + DF+ + L ++G+L Y+L + +F + R H
Sbjct: 1046 TTQAPSLLLFINSS----SQDFVVVLLCKNGSLQVRYHLNKEETHVFTIDADNFANRRMH 1101
Query: 285 RVKAVRDGQSGKITVD 300
+K R+G+ I +D
Sbjct: 1102 HLKINREGRELTIQMD 1117
Score = 53.9 bits (128), Expect = 2e-07
Identities = 78/330 (23%), Positives = 120/330 (36%), Gaps = 52/330 (15%)
Query: 5 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDP-LTLGN--- 60
+ F+ GDGVL + + D +++ L G + + G L S P TLG+
Sbjct: 207 LKFKSMQGDGVLFHG-EGQRGDHITLELQKGRLALHLNLGDSKARLSSSLPSATLGSLLD 265
Query: 61 ---WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 117
WH + + R K VDK +G + + ++ GG+P K + +
Sbjct: 266 DQHWHSVLIERVGKQVNFTVDKHT-QHFRTKGETDALDIDYELSFGGIPVPG--KPGTFL 322
Query: 118 LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCP 177
K F G I+ + N GVN+ + A R + + Y
Sbjct: 323 KKNFHGCIENLYYN------------GVNIIDLAK-------------RRKHQIYT---- 353
Query: 178 LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLW 237
G C + I I G L P I +V +F+T KDGLLL
Sbjct: 354 -GNVTFSCSEPQIVPITFVNSSGSYLLLPGTPQI------DGLSVSFQFRTWNKDGLLL- 405
Query: 238 RGDSPMRPNSDFISLGLRDGAL-VFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGK 296
+ + S + L L G L + + VA I+ + NDG WH V
Sbjct: 406 --STELSEGSGTLLLSLEGGILRLVIQKMTERVAEILTGSNLNDGLWHSVSINARRNRIT 463
Query: 297 ITVDDYGARTGKSPGMMRQLNINGALYVGG 326
+T+DD A + Q+ + Y GG
Sbjct: 464 LTLDDEAAPPAPDSTWV-QIYSGNSYYFGG 492
Score = 45.4 bits (106), Expect = 8e-05
Identities = 40/132 (30%), Positives = 63/132 (47%), Gaps = 19/132 (14%)
Query: 226 FKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGA-LVFSYNLGSGVASIMVNGS--FNDGR 282
FKTTA G+ L DFI L + + + F+ ++G+G ++V ND +
Sbjct: 819 FKTTALSGVFLENLGI-----KDFIRLEISSPSEITFAIDVGNGPVELVVQSPSLLNDNQ 873
Query: 283 WHRVKAVRDGQSGKITVDDY--GARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMR 340
WH V+A R+ + + VD+ R G R L +N L+VGG ++RQ +
Sbjct: 874 WHYVRAERNLKETSLQVDNLPRSTRETSEEGHFR-LQLNSQLFVGGT------SSRQ--K 924
Query: 341 GLVGCISHFTLS 352
G +GCI L+
Sbjct: 925 GFLGCIRSLHLN 936
Score = 43.5 bits (101), Expect = 3e-04
Identities = 40/141 (28%), Positives = 64/141 (45%), Gaps = 14/141 (9%)
Query: 194 EIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLG 253
++ F GRS L Y K +S + + ++FK+ DG+L + G+ D I+L
Sbjct: 179 DVADFDGRSSLLYRFNQ--KLMSTLKDVISLKFKSMQGDGVL-FHGEGQ---RGDHITLE 232
Query: 254 LRDGALVFSYNLG-------SGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGART 306
L+ G L NLG S + S + +D WH V R G+ TVD + +
Sbjct: 233 LQKGRLALHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVGKQVNFTVDKH-TQH 291
Query: 307 GKSPGMMRQLNINGALYVGGM 327
++ G L+I+ L GG+
Sbjct: 292 FRTKGETDALDIDYELSFGGI 312
Score = 39.3 bits (90), Expect = 0.006
Identities = 40/195 (20%), Positives = 76/195 (38%), Gaps = 11/195 (5%)
Query: 7 FRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFD-CGSGTGVLRSEDPLTLGNWHELR 65
FR + DG+LL + + L ++L GG + + + L G WH +
Sbjct: 395 FRTWNKDGLLLSTELSEGSGTLLLSLEGGILRLVIQKMTERVAEILTGSNLNDGLWHSVS 454
Query: 66 VSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSI 125
++ L +D + + + QI + GG P+ + +K F G +
Sbjct: 455 INARRNRITLTLDDEAAPPA-PDSTWVQIYSGNSYYFGGCPDNLTDSQCLNPIKAFQGCM 513
Query: 126 QKIILNDRT---IHVKHDFTSG-----VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDC- 176
+ I ++++ I V+ +++ + C+ C HGGSC + C+C
Sbjct: 514 RLIFIDNQPKDLISVQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCS 573
Query: 177 PLGFEGLHCQKAIIE 191
+ G C +I E
Sbjct: 574 DTSYTGATCHNSIYE 588
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 85.5 bits (210), Expect = 7e-17
Identities = 93/374 (24%), Positives = 153/374 (40%), Gaps = 64/374 (17%)
Query: 13 DGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN--WHELRVSRTA 70
D +L Y DFL+I + G V F +D GSG G + D LT+ + W+ + SRT
Sbjct: 2180 DNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPD-LTIDDSYWYRIVASRTG 2238
Query: 71 KNGILQV-----DKQKIV----EGMAEGGFT--QIKCNTDIFIGGVPNYDDVKKNSGV-L 118
+NG + V K IV + G+T + N +F+GG+ +KK V +
Sbjct: 2239 RNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTG--KLKKADAVRV 2296
Query: 119 KPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPL 178
F+G + + +++ I G R++ DC
Sbjct: 2297 ITFTGCMGETYFDNKPI---------------------------GLWNFREKEGDC---- 2325
Query: 179 GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWR 238
+G + ++ QF G Y P R + S V +F+T + LL++
Sbjct: 2326 --KGCTVSPQVEDSEGTIQFDGEGYALVSRPI---RWYPNISTVMFKFRTFSSSALLMYL 2380
Query: 239 GDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 298
+R DF+S+ L DG + SY+LGSG+AS++ N + NDG+W R + I+
Sbjct: 2381 ATRDLR---DFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANIS 2437
Query: 299 VDDYG-------ARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 351
+ D A + L + +Y GG+ + ++ GC+ +
Sbjct: 2438 IVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLRPEVNLKKYSGCLKDIEI 2497
Query: 352 S-TDYHISLVEDAV 364
S T Y+I D V
Sbjct: 2498 SRTPYNILSSPDYV 2511
Score = 73.9 bits (180), Expect = 2e-13
Identities = 90/321 (28%), Positives = 143/321 (44%), Gaps = 41/321 (12%)
Query: 30 INLAGGHVEFRFDCGSGTG---VLRSEDPLTL-GNWHELRVSRTAKNGILQVDK-QKIVE 84
I L G +E G+ T V+R E L G H + V RT +QVD+ ++ ++
Sbjct: 2584 ILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQ 2643
Query: 85 GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSG 144
+ ++K +F+GG P + PF G I +++N V DF
Sbjct: 2644 NLTVEQPIEVK---KLFVGGAPPEFQPSPLRNI-PPFEGCIWNLVINS----VPMDFARP 2695
Query: 145 VNVENA-----AHPCVR------APCAHGGSCRP-RKEGYDCDCPLGFEGLHCQKAIIEA 192
V+ +NA AH +R AP P + P+ G C A
Sbjct: 2696 VSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHG-PCAAESEPA 2754
Query: 193 IEI--PQF-IGRSY---LTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPN 246
+ I QF + R+ + +D+ + R++ + + +T A+ GLL + +
Sbjct: 2755 LLIGSKQFGLSRNSHIAIAFDDTKVKNRLT-----IELEVRTEAESGLLFYMARIN---H 2806
Query: 247 SDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGART 306
+DF ++ LR+G FSY+LGSG M+ NDG+WH++K +R Q G + VD RT
Sbjct: 2807 ADFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT 2866
Query: 307 GKSPGMMRQLNINGALYVGGM 327
SP L++ G LYVGG+
Sbjct: 2867 -ISPKKADILDVVGMLYVGGL 2886
Score = 61.2 bits (147), Expect = 1e-09
Identities = 78/370 (21%), Positives = 133/370 (35%), Gaps = 80/370 (21%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 60
+ E+ R ++ G+L Y DF ++ L G F +D GSG + G
Sbjct: 2783 LTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQ 2842
Query: 61 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNT-----DIFIGGVPNYDDVKKNS 115
WH++++ R+ + GIL VD G + + K + +++GG+P ++
Sbjct: 2843 WHKIKIMRSKQEGILYVD------GASNRTISPKKADILDVVGMLYVGGLPINYTTRRIG 2896
Query: 116 GVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCD 175
V G ++ + + + ++ +S H G+C
Sbjct: 2897 PVTYSIDGCVRNLHMAEAPADLEQPTSS----------------FHVGTC---------- 2930
Query: 176 CPLGFEGLHCQKAIIEAIEIPQFIGRSYLTY-DNPDILKRVSGSRSN----VFMRFKTTA 230
F TY D K V G + V F+TT
Sbjct: 2931 ----------------------FANAQRGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTT 2968
Query: 231 KDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG----VASIMVNGSFNDGRWHRV 286
G+LL M D + + + D L+F + G+G V V G DG+WH+V
Sbjct: 2969 TTGVLLGISSQKM----DGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKV 3024
Query: 287 KAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG----MKEIALHTNRQYMRGL 342
A + ++TVD + N ++VGG +K+ L T+ +
Sbjct: 3025 TANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFR--- 3081
Query: 343 VGCISHFTLS 352
GCI L+
Sbjct: 3082 -GCIRSLKLT 3090
Score = 54.7 bits (130), Expect = 1e-07
Identities = 39/155 (25%), Positives = 70/155 (45%), Gaps = 13/155 (8%)
Query: 7 FRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRV 66
FR S +L+Y +DF+S+ L GH++ +D GSG + S G W +
Sbjct: 2368 FRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTL 2427
Query: 67 SRTAKN---GILQVD---KQKIVEGMAEGGF-TQIKCNTDIFIGGVPNYDDVKKNSGVLK 119
SR K I+ +D ++ I + F +K + I+ GG+P +++ LK
Sbjct: 2428 SRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLRPEVN-LK 2486
Query: 120 PFSGSIQKIILNDRTIHVKHD-----FTSGVNVEN 149
+SG ++ I ++ ++ T G ++EN
Sbjct: 2487 KYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLEN 2521
Score = 52.0 bits (123), Expect = 9e-07
Identities = 37/131 (28%), Positives = 66/131 (50%), Gaps = 18/131 (13%)
Query: 209 PDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG 268
P+I K GS +N+ + KT D LL + G + DF+++ +R G + F +++GSG
Sbjct: 2160 PEIKK---GSYNNIVVNVKTAVADNLLFYLGSAKF---IDFLAIEMRKGKVSFLWDVGSG 2213
Query: 269 VASI-MVNGSFNDGRWHRVKAVRDGQSGKITVDDYGA----------RTGKSPG-MMRQL 316
V + + + +D W+R+ A R G++G I+V + PG + +
Sbjct: 2214 VGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDV 2273
Query: 317 NINGALYVGGM 327
+ N L+VGG+
Sbjct: 2274 DANAMLFVGGL 2284
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/136 (27%), Positives = 57/136 (41%), Gaps = 8/136 (5%)
Query: 4 EITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSG--TGVLRSEDP--LTLG 59
E FR + GVLL + D + I + + F D G+G T V + P L G
Sbjct: 2961 EFEFRTTTTTGVLL-GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDG 3019
Query: 60 NWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 119
WH++ ++ L VD ++ T N +F+GG P DD+K+
Sbjct: 3020 QWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFP--DDLKQFGLTTS 3077
Query: 120 -PFSGSIQKIILNDRT 134
PF G I+ + L T
Sbjct: 3078 IPFRGCIRSLKLTKGT 3093
Score = 29.6 bits (65), Expect = 4.6
Identities = 9/16 (56%), Positives = 12/16 (75%)
Query: 174 CDCPLGFEGLHCQKAI 189
CDCPLG+ GL C+ +
Sbjct: 1380 CDCPLGYSGLSCEACL 1395
>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
Length = 3075
Score = 84.7 bits (208), Expect = 1e-16
Identities = 83/358 (23%), Positives = 147/358 (41%), Gaps = 63/358 (17%)
Query: 13 DGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSED-PLTLGNWHELRVSRTAK 71
D +L Y + + DFL++ + G V F +D GSG+ L D P+ WH + V+R
Sbjct: 2152 DNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDFPIDDNRWHSIHVARFGN 2211
Query: 72 NGILQVDKQ--------KIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV-LKPFS 122
G L V + K + + +T +F+GG+ +KK+ V + F
Sbjct: 2212 IGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFVGGLGG--QIKKSPAVKVTHFK 2269
Query: 123 GSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEG 182
G + + LN ++I + + + E C GS + + D
Sbjct: 2270 GCLGEAFLNGKSIGL----WNYIEREGKCRGCF-------GSSQNEDPSFHFD------- 2311
Query: 183 LHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSP 242
G Y + K + + + + M F T + +GLLL+ G
Sbjct: 2312 -----------------GSGYSVVE-----KSLPATVTQIIMLFNTFSPNGLLLYLGSYG 2349
Query: 243 MRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITV-DD 301
+ DF+S+ L G + +LGSG +++ + +N+G W+++ R+ + G + V D
Sbjct: 2350 TK---DFLSIELFRGRVKVMTDLGSGPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDA 2406
Query: 302 YG-----ARTGKSPGMMRQLN--INGALYVGGMKEIALHTNRQYMRGLVGCISHFTLS 352
Y + G++PG LN +YVGG+ + + VGCI + +S
Sbjct: 2407 YNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKNLEIS 2464
Score = 72.8 bits (177), Expect = 5e-13
Identities = 85/376 (22%), Positives = 153/376 (40%), Gaps = 58/376 (15%)
Query: 2 EFEITFRPDSGDGVLLYSYD-----TGSKD-----FLSINLAGGHVEFRFDCGSGTGVLR 51
E+ +TF + G++L + G ++ F S+ L GG++E + G GTG+ +
Sbjct: 2509 EWLVTFATTNSSGIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRK 2568
Query: 52 S-----EDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCN--TDIFIGG 104
+ + G H + + R + +Q+D+ VE M G + + +++++GG
Sbjct: 2569 ALLHAPTGTCSDGQAHSISLVRNRRIITVQLDENNPVE-MKLGTLVESRTINVSNLYVGG 2627
Query: 105 VPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENA-------AHPCVRA 157
+P + + + + F G I+ +I N + DF S V E + A
Sbjct: 2628 IPEGEGTSLLT-MRRSFHGCIKNLIFNLELL----DFNSAVGHEQVDLDTCWLSERPKLA 2682
Query: 158 PCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSY-----LTYDNPDIL 212
P A P + C + A +E + G + L ++ +
Sbjct: 2683 PDAEDSKLLPEPRAFPEQCVVD--------AALEYVPGAHQFGLTQNSHFILPFNQSAVR 2734
Query: 213 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 272
K++S V + +T A GL+ + + +D+ L L G L F ++LG G +
Sbjct: 2735 KKLS-----VELSIRTFASSGLIYYMAH---QNQADYAVLQLHGGRLHFMFDLGKGRTKV 2786
Query: 273 MVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIAL 332
+DG+WH VK + G ITVD + G L++ G Y+GG+
Sbjct: 2787 SHPALLSDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPS--- 2843
Query: 333 HTNRQYMRGLVGCISH 348
QY +G I+H
Sbjct: 2844 ----QYQARKIGNITH 2855
Score = 68.6 bits (166), Expect = 9e-12
Identities = 68/330 (20%), Positives = 121/330 (36%), Gaps = 50/330 (15%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 60
+ E++ R + G++ Y D+ + L GG + F FD G G + L+ G
Sbjct: 2737 LSVELSIRTFASSGLIYYMAHQNQADYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGK 2796
Query: 61 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP 120
WH ++ + G + VD ++ G T + ++GG+P+ +K +
Sbjct: 2797 WHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHS 2856
Query: 121 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 180
I + +N + + K S V N + + GS GY L
Sbjct: 2857 IPACIGDVTVNSKQLD-KDSPVSAFTV-NRCYAVAQEGTYFDGS------GY---AALVK 2905
Query: 181 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 240
EG Q + N+ + F+T++++G+LL
Sbjct: 2906 EGYKVQSDV-------------------------------NITLEFRTSSQNGVLLGIST 2934
Query: 241 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS----FNDGRWHRVKAVRDGQSGK 296
+ + D I L L DG ++F N G+G + DG+WH ++A +
Sbjct: 2935 AKV----DAIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRIT 2990
Query: 297 ITVDDYGARTGKSPGMMRQLNINGALYVGG 326
+ VD ++ N +YVGG
Sbjct: 2991 LIVDGNAVGAESPHTQSTSVDTNNPIYVGG 3020
Score = 67.0 bits (162), Expect = 3e-11
Identities = 89/390 (22%), Positives = 152/390 (38%), Gaps = 73/390 (18%)
Query: 7 FRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRV 66
F S +G+LLY G+KDFLSI L G V+ D GSG L ++ G W+++
Sbjct: 2333 FNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPITLLTDRRYNNGTWYKIAF 2392
Query: 67 SRTAKNGILQV------DKQKIVEGMAEGGFTQI-KCNTD-IFIGGVPNYDDVKKNSGVL 118
R K G+L V ++ +G G + + + + D I++GG+P V +
Sbjct: 2393 QRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPR-SRVVRRGVTT 2451
Query: 119 KPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPL 178
K F G I+ + ++ T + + VR C
Sbjct: 2452 KSFVGCIKNLEISRSTFDLLRNSYG-----------VRKGC------------------- 2481
Query: 179 GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLL-- 236
++E I F+ Y+ ++ + S + F TT G++L
Sbjct: 2482 ----------LLEPIRSVSFLKGGYI-----ELPPKSLSPESEWLVTFATTNSSGIILAA 2526
Query: 237 WRGDSPMRPNSD-----FISLGLRDGALVFSYNLGSGVASIMV-----NGSFNDGRWHRV 286
GD R + + F S+ L G + N G G G+ +DG+ H +
Sbjct: 2527 LGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSI 2586
Query: 287 KAVRDGQSGKITVDDYGARTGKSPGMMRQLNIN-GALYVGGMKEIALHTNRQYMRGLVGC 345
VR+ + + +D+ K ++ IN LYVGG+ E + R GC
Sbjct: 2587 SLVRNRRIITVQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTSLLTMRRSFHGC 2646
Query: 346 ISHFTLS---TDYHISLVEDAVDGKNINTC 372
I + + D++ ++ + VD ++TC
Sbjct: 2647 IKNLIFNLELLDFNSAVGHEQVD---LDTC 2673
Score = 58.5 bits (140), Expect = 9e-09
Identities = 36/121 (29%), Positives = 63/121 (52%), Gaps = 12/121 (9%)
Query: 216 SGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI-MV 274
S + + + + KT D LL + G S SDF+++ +R G + F ++LGSG +
Sbjct: 2136 STNYNTLTLNVKTQEPDNLLFYLGSSTA---SDFLAVEMRRGRVAFLWDLGSGSTRLEFP 2192
Query: 275 NGSFNDGRWHRVKAVRDGQSGKITVDDYGA------RTGKSPGMMRQLNINGA--LYVGG 326
+ +D RWH + R G G ++V + + +T KSPG L++N + ++VGG
Sbjct: 2193 DFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFVGG 2252
Query: 327 M 327
+
Sbjct: 2253 L 2253
Score = 42.7 bits (99), Expect = 5e-04
Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 7/107 (6%)
Query: 5 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL-----G 59
+ FR S +GVLL T D + + L G V F + G+G + + +P T G
Sbjct: 2918 LEFRTSSQNGVLL-GISTAKVDAIGLELVDGKVLFHVNNGAGR-ITAAYEPKTATVLCDG 2975
Query: 60 NWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVP 106
WH L+ +++ L VD + T + N I++GG P
Sbjct: 2976 KWHTLQANKSKHRITLIVDGNAVGAESPHTQSTSVDTNNPIYVGGYP 3022
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 82.8 bits (203), Expect = 5e-16
Identities = 93/378 (24%), Positives = 157/378 (41%), Gaps = 68/378 (17%)
Query: 13 DGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN--WHELRVSRTA 70
D +L Y DFL+I + G V F +D GSG G + D LT+ + W+ + SRT
Sbjct: 2180 DNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPD-LTIDDSYWYRIVASRTG 2238
Query: 71 KNGILQV-----DKQKIV----EGMAEGGFT--QIKCNTDIFIGGVPNYDDVKKNSGV-L 118
+NG + V K IV + G+T + N +F+GG+ +KK V +
Sbjct: 2239 RNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTG--KLKKADAVRV 2296
Query: 119 KPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPL 178
F+G + + +++ I G R++ DC
Sbjct: 2297 ITFTGCMGETYFDNKPI---------------------------GLWNFREKEGDC---- 2325
Query: 179 GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWR 238
+G + ++ QF G Y P R + S V +F+T + LL++
Sbjct: 2326 --KGCTVSPQVEDSEGTIQFDGEGYALVSRPI---RWYPNISTVMFKFRTFSSSALLMYL 2380
Query: 239 GDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 298
+R DF+S+ L DG + SY+LGSG+AS++ N + NDG+W R + I+
Sbjct: 2381 ATRDLR---DFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANIS 2437
Query: 299 VDDYG-------ARTGKSPGMMRQLNINGALYVGG---MKEIALHTNRQY-MRGLVGCIS 347
+ D A + L + +Y GG ++ +++ + ++ GC+
Sbjct: 2438 IVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLK 2497
Query: 348 HFTLS-TDYHISLVEDAV 364
+S T Y+I D V
Sbjct: 2498 DIEISRTPYNILSSPDYV 2515
Score = 73.9 bits (180), Expect = 2e-13
Identities = 90/321 (28%), Positives = 143/321 (44%), Gaps = 41/321 (12%)
Query: 30 INLAGGHVEFRFDCGSGTG---VLRSEDPLTL-GNWHELRVSRTAKNGILQVDK-QKIVE 84
I L G +E G+ T V+R E L G H + V RT +QVD+ ++ ++
Sbjct: 2588 ILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQ 2647
Query: 85 GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSG 144
+ ++K +F+GG P + PF G I +++N V DF
Sbjct: 2648 NLTVEQPIEVK---KLFVGGAPPEFQPSPLRNI-PPFEGCIWNLVINS----VPMDFARP 2699
Query: 145 VNVENA-----AHPCVR------APCAHGGSCRP-RKEGYDCDCPLGFEGLHCQKAIIEA 192
V+ +NA AH +R AP P + P+ G C A
Sbjct: 2700 VSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHG-PCAAESEPA 2758
Query: 193 IEI--PQF-IGRSY---LTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPN 246
+ I QF + R+ + +D+ + R++ + + +T A+ GLL + +
Sbjct: 2759 LLIGSKQFGLSRNSHIAIAFDDTKVKNRLT-----IELEVRTEAESGLLFYMARIN---H 2810
Query: 247 SDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGART 306
+DF ++ LR+G FSY+LGSG M+ NDG+WH++K +R Q G + VD RT
Sbjct: 2811 ADFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT 2870
Query: 307 GKSPGMMRQLNINGALYVGGM 327
SP L++ G LYVGG+
Sbjct: 2871 -ISPKKADILDVVGMLYVGGL 2890
Score = 61.2 bits (147), Expect = 1e-09
Identities = 78/370 (21%), Positives = 133/370 (35%), Gaps = 80/370 (21%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 60
+ E+ R ++ G+L Y DF ++ L G F +D GSG + G
Sbjct: 2787 LTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQ 2846
Query: 61 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNT-----DIFIGGVPNYDDVKKNS 115
WH++++ R+ + GIL VD G + + K + +++GG+P ++
Sbjct: 2847 WHKIKIMRSKQEGILYVD------GASNRTISPKKADILDVVGMLYVGGLPINYTTRRIG 2900
Query: 116 GVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCD 175
V G ++ + + + ++ +S H G+C
Sbjct: 2901 PVTYSIDGCVRNLHMAEAPADLEQPTSS----------------FHVGTC---------- 2934
Query: 176 CPLGFEGLHCQKAIIEAIEIPQFIGRSYLTY-DNPDILKRVSGSRSN----VFMRFKTTA 230
F TY D K V G + V F+TT
Sbjct: 2935 ----------------------FANAQRGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTT 2972
Query: 231 KDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG----VASIMVNGSFNDGRWHRV 286
G+LL M D + + + D L+F + G+G V V G DG+WH+V
Sbjct: 2973 TTGVLLGISSQKM----DGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKV 3028
Query: 287 KAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG----MKEIALHTNRQYMRGL 342
A + ++TVD + N ++VGG +K+ L T+ +
Sbjct: 3029 TANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFR--- 3085
Query: 343 VGCISHFTLS 352
GCI L+
Sbjct: 3086 -GCIRSLKLT 3094
Score = 52.8 bits (125), Expect = 5e-07
Identities = 39/158 (24%), Positives = 70/158 (44%), Gaps = 15/158 (9%)
Query: 7 FRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRV 66
FR S +L+Y +DF+S+ L GH++ +D GSG + S G W +
Sbjct: 2368 FRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTL 2427
Query: 67 SRTAKN---GILQVD---KQKIVEGMAEGGF-TQIKCNTDIFIGGVPNYDDVKKNSGV-- 117
SR K I+ +D ++ I + F +K + I+ GG+P ++ +
Sbjct: 2428 SRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEV 2487
Query: 118 -LKPFSGSIQKIILNDRTIHVKHD-----FTSGVNVEN 149
LK +SG ++ I ++ ++ T G ++EN
Sbjct: 2488 NLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLEN 2525
Score = 52.0 bits (123), Expect = 9e-07
Identities = 37/131 (28%), Positives = 66/131 (50%), Gaps = 18/131 (13%)
Query: 209 PDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG 268
P+I K GS +N+ + KT D LL + G + DF+++ +R G + F +++GSG
Sbjct: 2160 PEIKK---GSYNNIVVNVKTAVADNLLFYLGSAKF---IDFLAIEMRKGKVSFLWDVGSG 2213
Query: 269 VASI-MVNGSFNDGRWHRVKAVRDGQSGKITVDDYGA----------RTGKSPG-MMRQL 316
V + + + +D W+R+ A R G++G I+V + PG + +
Sbjct: 2214 VGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDV 2273
Query: 317 NINGALYVGGM 327
+ N L+VGG+
Sbjct: 2274 DANAMLFVGGL 2284
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/136 (27%), Positives = 57/136 (41%), Gaps = 8/136 (5%)
Query: 4 EITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSG--TGVLRSEDP--LTLG 59
E FR + GVLL + D + I + + F D G+G T V + P L G
Sbjct: 2965 EFEFRTTTTTGVLL-GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDG 3023
Query: 60 NWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 119
WH++ ++ L VD ++ T N +F+GG P DD+K+
Sbjct: 3024 QWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFP--DDLKQFGLTTS 3081
Query: 120 -PFSGSIQKIILNDRT 134
PF G I+ + L T
Sbjct: 3082 IPFRGCIRSLKLTKGT 3097
Score = 29.6 bits (65), Expect = 4.6
Identities = 9/16 (56%), Positives = 12/16 (75%)
Query: 174 CDCPLGFEGLHCQKAI 189
CDCPLG+ GL C+ +
Sbjct: 1380 CDCPLGYSGLSCEACL 1395
>gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
Length = 1816
Score = 80.9 bits (198), Expect = 2e-15
Identities = 89/382 (23%), Positives = 151/382 (39%), Gaps = 62/382 (16%)
Query: 2 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNW 61
+F I R S G++ Y D DF+++ LA G + + F+ G +RS++ G W
Sbjct: 1487 QFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLW 1546
Query: 62 HELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK-NSGVLKP 120
H++ R +G L +D +++E K I++GGV VK +
Sbjct: 1547 HDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYS 1606
Query: 121 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 180
FSG + + LN G ++ +A+ PC G P + G G+
Sbjct: 1607 FSGCLSNLQLN------------GASITSASQTFSVTPCFEG----PMETGTYFSTEGGY 1650
Query: 181 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 240
L E+ I G + + + + G L+ G
Sbjct: 1651 VVLD------ESFNI---------------------GLKFEIAFEVRPRSSSGTLV-HGH 1682
Query: 241 SPMRPNSDFISLGLRDGALVFSYNLG--SGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 298
S N +++++ +++G ++ N G S+ S DGRWHR+ +RD ++
Sbjct: 1683 S---VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQLD 1739
Query: 299 VDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYH-- 356
VD P + ++ ++VGG+ E L + GCI HF + D H
Sbjct: 1740 VDS-EVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI--DGHPV 1796
Query: 357 ----ISLVEDAVDGKNINTCGA 374
+LV AV +IN+C A
Sbjct: 1797 SFSKAALVSGAV---SINSCPA 1815
Score = 65.1 bits (157), Expect = 1e-10
Identities = 40/143 (27%), Positives = 68/143 (47%), Gaps = 5/143 (3%)
Query: 212 LKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS 271
LK G++S +R +T + G++ + D + +DF++L L G LV+ +N+G
Sbjct: 1478 LKGDFGAKSQFSIRLRTRSSHGMIFYVSD---QEENDFMTLFLAHGRLVYMFNVGHKKLK 1534
Query: 272 IMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIA 331
I +NDG WH V +R+ SG++ +D P I G +Y+GG+
Sbjct: 1535 IRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGK 1594
Query: 332 LHTNRQY--MRGLVGCISHFTLS 352
N Q + GC+S+ L+
Sbjct: 1595 AVKNVQINSIYSFSGCLSNLQLN 1617
Score = 34.3 bits (77), Expect = 0.19
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 17/142 (11%)
Query: 228 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG---SFNDGRWH 284
T D +L+ G + +++ L +++ LV+ YNLG+ I ++ S +
Sbjct: 868 TETADQFILYLGSKNAK--KEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFS 925
Query: 285 RVKAVRDGQSGKI---------TVDDYGARTGKSPGMMRQLNI---NGALYVGGMKEIAL 332
VK R G+ GK+ T ++ + G+ G L++ + YVGG+
Sbjct: 926 IVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFK 985
Query: 333 HTNRQYMRGLVGCISHFTLSTD 354
+ G VGC+ TL+ D
Sbjct: 986 LPTSLNLPGFVGCLELATLNND 1007
Score = 31.2 bits (69), Expect = 1.6
Identities = 31/111 (27%), Positives = 52/111 (46%), Gaps = 13/111 (11%)
Query: 3 FEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN-- 60
F+I R + +G++L + GS F + + G++ +D G G + ED L
Sbjct: 1068 FDIEVRTPADNGLILLMVN-GSM-FFRLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQIN 1125
Query: 61 ---WHELRVS-RTAKNGILQVDKQKIVEGMAEGGFTQIKCN-TDIFIGGVP 106
+HE+ + K IL VD++ + E ++K TDI+IGG P
Sbjct: 1126 DAKYHEISIIYHNDKKMILVVDRRHVKSMDNE----KMKIPFTDIYIGGAP 1172
>gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens]
Length = 1823
Score = 80.9 bits (198), Expect = 2e-15
Identities = 89/382 (23%), Positives = 151/382 (39%), Gaps = 62/382 (16%)
Query: 2 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNW 61
+F I R S G++ Y D DF+++ LA G + + F+ G +RS++ G W
Sbjct: 1494 QFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLW 1553
Query: 62 HELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK-NSGVLKP 120
H++ R +G L +D +++E K I++GGV VK +
Sbjct: 1554 HDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYS 1613
Query: 121 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 180
FSG + + LN G ++ +A+ PC G P + G G+
Sbjct: 1614 FSGCLSNLQLN------------GASITSASQTFSVTPCFEG----PMETGTYFSTEGGY 1657
Query: 181 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 240
L E+ I G + + + + G L+ G
Sbjct: 1658 VVLD------ESFNI---------------------GLKFEIAFEVRPRSSSGTLV-HGH 1689
Query: 241 SPMRPNSDFISLGLRDGALVFSYNLG--SGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 298
S N +++++ +++G ++ N G S+ S DGRWHR+ +RD ++
Sbjct: 1690 S---VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQLD 1746
Query: 299 VDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYH-- 356
VD P + ++ ++VGG+ E L + GCI HF + D H
Sbjct: 1747 VDS-EVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI--DGHPV 1803
Query: 357 ----ISLVEDAVDGKNINTCGA 374
+LV AV +IN+C A
Sbjct: 1804 SFSKAALVSGAV---SINSCPA 1822
Score = 65.1 bits (157), Expect = 1e-10
Identities = 40/143 (27%), Positives = 68/143 (47%), Gaps = 5/143 (3%)
Query: 212 LKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS 271
LK G++S +R +T + G++ + D + +DF++L L G LV+ +N+G
Sbjct: 1485 LKGDFGAKSQFSIRLRTRSSHGMIFYVSD---QEENDFMTLFLAHGRLVYMFNVGHKKLK 1541
Query: 272 IMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIA 331
I +NDG WH V +R+ SG++ +D P I G +Y+GG+
Sbjct: 1542 IRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGK 1601
Query: 332 LHTNRQY--MRGLVGCISHFTLS 352
N Q + GC+S+ L+
Sbjct: 1602 AVKNVQINSIYSFSGCLSNLQLN 1624
Score = 34.3 bits (77), Expect = 0.19
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 17/142 (11%)
Query: 228 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG---SFNDGRWH 284
T D +L+ G + +++ L +++ LV+ YNLG+ I ++ S +
Sbjct: 875 TETADQFILYLGSKNAK--KEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFS 932
Query: 285 RVKAVRDGQSGKI---------TVDDYGARTGKSPGMMRQLNI---NGALYVGGMKEIAL 332
VK R G+ GK+ T ++ + G+ G L++ + YVGG+
Sbjct: 933 IVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFK 992
Query: 333 HTNRQYMRGLVGCISHFTLSTD 354
+ G VGC+ TL+ D
Sbjct: 993 LPTSLNLPGFVGCLELATLNND 1014
Score = 31.2 bits (69), Expect = 1.6
Identities = 31/111 (27%), Positives = 52/111 (46%), Gaps = 13/111 (11%)
Query: 3 FEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN-- 60
F+I R + +G++L + GS F + + G++ +D G G + ED L
Sbjct: 1075 FDIEVRTPADNGLILLMVN-GSM-FFRLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQIN 1132
Query: 61 ---WHELRVS-RTAKNGILQVDKQKIVEGMAEGGFTQIKCN-TDIFIGGVP 106
+HE+ + K IL VD++ + E ++K TDI+IGG P
Sbjct: 1133 DAKYHEISIIYHNDKKMILVVDRRHVKSMDNE----KMKIPFTDIYIGGAP 1179
>gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
Length = 1816
Score = 80.9 bits (198), Expect = 2e-15
Identities = 89/382 (23%), Positives = 151/382 (39%), Gaps = 62/382 (16%)
Query: 2 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNW 61
+F I R S G++ Y D DF+++ LA G + + F+ G +RS++ G W
Sbjct: 1487 QFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLW 1546
Query: 62 HELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK-NSGVLKP 120
H++ R +G L +D +++E K I++GGV VK +
Sbjct: 1547 HDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYS 1606
Query: 121 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 180
FSG + + LN G ++ +A+ PC G P + G G+
Sbjct: 1607 FSGCLSNLQLN------------GASITSASQTFSVTPCFEG----PMETGTYFSTEGGY 1650
Query: 181 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 240
L E+ I G + + + + G L+ G
Sbjct: 1651 VVLD------ESFNI---------------------GLKFEIAFEVRPRSSSGTLV-HGH 1682
Query: 241 SPMRPNSDFISLGLRDGALVFSYNLG--SGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 298
S N +++++ +++G ++ N G S+ S DGRWHR+ +RD ++
Sbjct: 1683 S---VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQLD 1739
Query: 299 VDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYH-- 356
VD P + ++ ++VGG+ E L + GCI HF + D H
Sbjct: 1740 VDS-EVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI--DGHPV 1796
Query: 357 ----ISLVEDAVDGKNINTCGA 374
+LV AV +IN+C A
Sbjct: 1797 SFSKAALVSGAV---SINSCPA 1815
Score = 65.1 bits (157), Expect = 1e-10
Identities = 40/143 (27%), Positives = 68/143 (47%), Gaps = 5/143 (3%)
Query: 212 LKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS 271
LK G++S +R +T + G++ + D + +DF++L L G LV+ +N+G
Sbjct: 1478 LKGDFGAKSQFSIRLRTRSSHGMIFYVSD---QEENDFMTLFLAHGRLVYMFNVGHKKLK 1534
Query: 272 IMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIA 331
I +NDG WH V +R+ SG++ +D P I G +Y+GG+
Sbjct: 1535 IRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGK 1594
Query: 332 LHTNRQY--MRGLVGCISHFTLS 352
N Q + GC+S+ L+
Sbjct: 1595 AVKNVQINSIYSFSGCLSNLQLN 1617
Score = 34.3 bits (77), Expect = 0.19
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 17/142 (11%)
Query: 228 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG---SFNDGRWH 284
T D +L+ G + +++ L +++ LV+ YNLG+ I ++ S +
Sbjct: 868 TETADQFILYLGSKNAK--KEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFS 925
Query: 285 RVKAVRDGQSGKI---------TVDDYGARTGKSPGMMRQLNI---NGALYVGGMKEIAL 332
VK R G+ GK+ T ++ + G+ G L++ + YVGG+
Sbjct: 926 IVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFK 985
Query: 333 HTNRQYMRGLVGCISHFTLSTD 354
+ G VGC+ TL+ D
Sbjct: 986 LPTSLNLPGFVGCLELATLNND 1007
Score = 31.2 bits (69), Expect = 1.6
Identities = 31/111 (27%), Positives = 52/111 (46%), Gaps = 13/111 (11%)
Query: 3 FEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN-- 60
F+I R + +G++L + GS F + + G++ +D G G + ED L
Sbjct: 1068 FDIEVRTPADNGLILLMVN-GSM-FFRLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQIN 1125
Query: 61 ---WHELRVS-RTAKNGILQVDKQKIVEGMAEGGFTQIKCN-TDIFIGGVP 106
+HE+ + K IL VD++ + E ++K TDI+IGG P
Sbjct: 1126 DAKYHEISIIYHNDKKMILVVDRRHVKSMDNE----KMKIPFTDIYIGGAP 1172
>gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapiens]
Length = 1331
Score = 79.3 bits (194), Expect = 5e-15
Identities = 90/359 (25%), Positives = 150/359 (41%), Gaps = 53/359 (14%)
Query: 23 GSKDFLSINLAGG-HVEFRFDCGSGTG--VLRSEDPLTLGNWHELRVSRTAKNGILQVDK 79
G +DF+ + L V F FD G+G V+RS PL WH + R K LQVD+
Sbjct: 841 GKEDFIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDR 900
Query: 80 --QKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHV 137
Q+I + EG T+++ + +F+GG +G + F G I+ + +N T+ +
Sbjct: 901 LPQQIRKAPTEG-HTRLELYSQLFVGG----------AGGQQGFLGCIRSLRMNGVTLDL 949
Query: 138 KH--DFTSGVNVENAAHPCVR--APCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEA 192
+ TSG + + C C +GG C R GY CDC ++G C K +
Sbjct: 950 EERAKVTSGF-ISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAF 1008
Query: 193 IEIPQFIGRSYLTYDNPDILKRVSGSR----------------SNVFMRFKTTAKDGLLL 236
E ++ + P R S SR + F TT +LL
Sbjct: 1009 FEEGMWL---RYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILL 1065
Query: 237 WRGDSPMRPNSDFISLGLR-DGALVFSYNLGSGVASIMV---NGSFNDGRWHRVKAVRDG 292
+ +DF+++ ++ G+L YNLG + + + +G+ H V R
Sbjct: 1066 YISSF----TTDFLAVLVKPTGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHE 1121
Query: 293 QSGKITVDDYGARTGKSPGMMRQL-NINGALYVGGMKE---IALHTNRQYMRGLVGCIS 347
++ + +D Y + + P L N +L++G + E I ++ G GC+S
Sbjct: 1122 KTIFLKLDHYPSVSYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLS 1180
Score = 59.7 bits (143), Expect = 4e-09
Identities = 51/204 (25%), Positives = 86/204 (42%), Gaps = 27/204 (13%)
Query: 7 FRPDSGDGVLLYSYDTGSKDFLSINLA----GGHVEF------RFDCGSGTGVLRSEDPL 56
FR + +G+L++S+ + + I+L G H+ + D SG+G L
Sbjct: 401 FRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSG-------L 453
Query: 57 TLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSG 116
G WHE+R IL +D + + Q+K F GG N + +S
Sbjct: 454 NDGQWHEVRFLAKENFAILTIDGDE-ASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSV 512
Query: 117 VLKPFSGSIQKIILNDRTIHV------KHDFTSGVNVENAA--HPCVRAPCAHGGSCRPR 168
+ F G +Q I ++D+ +++ K + V+++ A CV C HGG C
Sbjct: 513 LQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQT 572
Query: 169 KEGYDCDC-PLGFEGLHCQKAIIE 191
+ + C C G+ G C +I E
Sbjct: 573 WDSFKCTCDETGYSGATCHNSIYE 596
Score = 47.8 bits (112), Expect = 2e-05
Identities = 30/95 (31%), Positives = 48/95 (50%), Gaps = 11/95 (11%)
Query: 213 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS----- 267
K++ + + + FKT+ +G++L G+ D+I+L L+ LV S NLGS
Sbjct: 203 KKMKTLKDVIALNFKTSESEGVIL-HGEGQQ---GDYITLELKKAKLVLSLNLGSNQLGP 258
Query: 268 --GVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 300
G S+M +D WH V R G+S +T+D
Sbjct: 259 IYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLD 293
Score = 42.7 bits (99), Expect = 5e-04
Identities = 62/307 (20%), Positives = 116/307 (37%), Gaps = 56/307 (18%)
Query: 5 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGT-GVLRSEDPLTLGN--- 60
+ F+ +GV+L+ + D++++ L + + GS G + + G+
Sbjct: 214 LNFKTSESEGVILHG-EGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLD 272
Query: 61 ---WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 117
WH + + R ++ L +D+ + G F + + +I GG+P K +S
Sbjct: 273 DHHWHSVVIERQGRSINLTLDRS-MQHFRTNGEFDYLDLDYEITFGGIPFSG--KPSSSS 329
Query: 118 LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCP 177
K F G ++ I N GVN+ + A P G + C
Sbjct: 330 RKNFKGCMESINYN------------GVNITDLARRKKLEPSNVGNL------SFSC--- 368
Query: 178 LGFEGLHCQKAIIEAIEIPQFIGR-SYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLL 236
+E +P F SYL ++ R++ +V +F+T +GLL+
Sbjct: 369 ------------VEPYTVPVFFNATSYL-----EVPGRLNQDLFSVSFQFRTWNPNGLLV 411
Query: 237 WRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS---IMVNGSFNDGRWHRVKAVRDGQ 293
+ S N + + L + + N+ S I NDG+WH V+ +
Sbjct: 412 F---SHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKEN 468
Query: 294 SGKITVD 300
+T+D
Sbjct: 469 FAILTID 475
>gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1
[Homo sapiens]
Length = 1288
Score = 78.2 bits (191), Expect = 1e-14
Identities = 91/356 (25%), Positives = 144/356 (40%), Gaps = 40/356 (11%)
Query: 17 LYSYDTGSKDFLSINL-AGGHVEFRFDCGSGTG--VLRSEDPLTLGNWHELRVSRTAKNG 73
++ + G DF+ I L A V F FD G+G ++S P WH +R R K
Sbjct: 829 VFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGA 888
Query: 74 ILQVDK--QKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILN 131
LQVD+ QK+ A+G +++ N+ +FIGG + F G I+ + LN
Sbjct: 889 SLQVDQLPQKMQPAPADG-HVRLQLNSQLFIGGTATRQ---------RGFLGCIRSLQLN 938
Query: 132 DRTIHVKH--DFTSGVNVENAAHPCVRAP-CAHGGSCRPRKEGYDCDCPL-GFEGLHCQK 187
+ ++ T GV A H C +GG CR ++ G CDC ++G C
Sbjct: 939 GVALDLEERATVTPGVEPGCAGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSN 998
Query: 188 AI----IEAIEIPQFIGRSYLTYDNPDIL-----KRVSGSRSNVFMRFKTTAKDGLLLWR 238
I + Y +N L + V+ +R + + F+TT LLL+
Sbjct: 999 EISAYFATGSSMTYHFQEHYTLSENSSSLVSSLYRDVTLTREMITLSFRTTRSPSLLLYV 1058
Query: 239 GDSPMRPNSDFISLGL-RDGALVFSYNLGSGVASIMVNGSFN---DGRWHRVKAVRDGQS 294
+++S+ L +G+L Y L F DG+ H+VK R+
Sbjct: 1059 SSF----YEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMADGQLHQVKINREEAV 1114
Query: 295 GKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIA---LHTNRQYMRGLVGCIS 347
+ V+ A+ + N +L +G + E A T R G GC+S
Sbjct: 1115 VMVEVNQ-SAKKQVILSSGTEFNAVKSLILGKVLEAAGADPDTRRAATSGFTGCLS 1169
Score = 37.0 bits (84), Expect = 0.029
Identities = 75/358 (20%), Positives = 127/358 (35%), Gaps = 59/358 (16%)
Query: 5 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDP---LTLGN- 60
+ F+ +G+LL+ + + +++ L G + F + SG L S LTLG+
Sbjct: 210 LKFKAMQSNGILLHR-EGQHGNHITLELIKGKLVFFLN--SGNAKLPSTIAPVTLTLGSL 266
Query: 61 -----WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 115
WH + + VDK A+G + + N +I GG+ + +
Sbjct: 267 LDDQHWHSVLIELLDTQVNFTVDKHTH-HFQAKGDSSNLDLNFEISFGGI--LSPGRSRA 323
Query: 116 GVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCD 175
K F G ++ + N GV+V A G + C
Sbjct: 324 FTRKSFHGCLENLYYN------------GVDVTELAKKHKPQILMMGNV------SFSCP 365
Query: 176 CPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLL 235
P + + + RSYL +VS V +F+T + G L
Sbjct: 366 QP-------------QTVPVTFLSSRSYLALPGNSGEDKVS-----VTFQFRTWNRAGHL 407
Query: 236 LWRGDSPMRPNSDFISLGLRDGALVFS-YNLGSGVASIMVNGSFNDGRWHRVKAVRDGQS 294
L+ ++ S L L+DG L S + G ++ NDG+WH V
Sbjct: 408 LF---GELQRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAGLNDGQWHSVSFSAKWSH 464
Query: 295 GKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTN-RQYMRGLVGCISHFTL 351
+ VDD T P + ++ Y GG + + + + G GC+ T+
Sbjct: 465 MNVVVDD---DTAVQPLVAVLIDSGDTYYFGGCLGNSSGSGCKSPLGGFQGCLRLITI 519
Score = 35.0 bits (79), Expect = 0.11
Identities = 41/195 (21%), Positives = 67/195 (34%), Gaps = 13/195 (6%)
Query: 7 FRPDSGDGVLLYS-YDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELR 65
FR + G LL+ GS F+ G F G + + L G WH +
Sbjct: 398 FRTWNRAGHLLFGELQRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAGLNDGQWHSVS 457
Query: 66 VSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSI 125
S + + VD V+ + I + GG L F G +
Sbjct: 458 FSAKWSHMNVVVDDDTAVQPLVA---VLIDSGDTYYFGGCLGNSSGSGCKSPLGGFQGCL 514
Query: 126 QKIILNDRTIH---VKHDFTSG-----VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDC- 176
+ I + D+ + V+ ++ C+ + C HGG C + + CDC
Sbjct: 515 RLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCL 574
Query: 177 PLGFEGLHCQKAIIE 191
G+ G C ++ E
Sbjct: 575 GTGYTGETCHSSLYE 589
>gi|47519929 cell recognition molecule CASPR3 [Homo sapiens]
Length = 1288
Score = 76.6 bits (187), Expect = 3e-14
Identities = 89/358 (24%), Positives = 142/358 (39%), Gaps = 44/358 (12%)
Query: 17 LYSYDTGSKDFLSINL-AGGHVEFRFDCGSGTG--VLRSEDPLTLGNWHELRVSRTAKNG 73
++ + G DF+ I L A V F FD G+G ++S P WH +R R K
Sbjct: 829 VFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGA 888
Query: 74 ILQVDK--QKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILN 131
LQVD+ QK+ A+G +++ N+ +FIGG + F G I+ + LN
Sbjct: 889 SLQVDQLPQKMQPAPADG-HVRLQLNSQLFIGGTATRQ---------RGFLGCIRSLQLN 938
Query: 132 DRTIHVKH--DFTSGVNVENAAHPCVRAP-CAHGGSCRPRKEGYDCDCPL-GFEGLHCQK 187
+ ++ T GV A H C +GG CR ++ G CDC ++G C
Sbjct: 939 GVALDLEERATVTPGVEPGCAGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSN 998
Query: 188 AI----IEAIEIPQFIGRSYLTYDNPDIL-----KRVSGSRSNVFMRFKTTAKDGLLLWR 238
I + Y +N L + V+ +R + + F+TT LLL+
Sbjct: 999 EISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVTLTREMITLSFRTTRTPSLLLYV 1058
Query: 239 GDSPMRPNSDFISLGL-RDGALVFSYNLGSGVASIMVNGSFN---DGRWHRVKAVRDGQS 294
+++S+ L +G+L Y L F DG+ H+VK R+
Sbjct: 1059 SSF----YEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMADGQLHQVKINREEAV 1114
Query: 295 GKITVDDYGAR-----TGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCIS 347
+ V+ + +G ++ L + L G T R G GC+S
Sbjct: 1115 VMVEVNQSTKKQVILSSGTEFNAVKSLILGKVLEAAGADP---DTRRAATSGFTGCLS 1169
Score = 40.8 bits (94), Expect = 0.002
Identities = 77/358 (21%), Positives = 129/358 (36%), Gaps = 59/358 (16%)
Query: 5 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDP---LTLGN- 60
+ F+ +G+LL+ + + +++ L G + F + SG L S LTLG+
Sbjct: 210 LKFKAMQSNGILLHR-EGQHGNHITLELIKGKLVFFLN--SGNAKLPSTIAPVTLTLGSL 266
Query: 61 -----WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 115
WH + + VDK A+G + + N +I GG+P + +
Sbjct: 267 LDDQHWHSVLIELLDTQVNFTVDKHTH-HFQAKGDSSYLDLNFEISFGGIPTPG--RSRA 323
Query: 116 GVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCD 175
K F G ++ + N GV+V A G + C
Sbjct: 324 FRRKSFHGCLENLYYN------------GVDVTELAKKHKPQILMMGNV------SFSCP 365
Query: 176 CPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLL 235
P + + + RSYL +VS V +F+T + G L
Sbjct: 366 QP-------------QTVPVTFLSSRSYLALPGNSGEDKVS-----VTFQFRTWNRAGHL 407
Query: 236 LWRGDSPMRPNSDFISLGLRDGALVFS-YNLGSGVASIMVNGSFNDGRWHRVKAVRDGQS 294
L+ +R S L L+DG L S + G ++ NDG+WH V
Sbjct: 408 LF---GELRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSH 464
Query: 295 GKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTN-RQYMRGLVGCISHFTL 351
+ VDD T P + ++ Y GG + + + + + G GC+ T+
Sbjct: 465 MNVVVDD---DTAVQPLVAVLIDSGDTYYFGGCLDNSSGSGCKSPLGGFQGCLRLITI 519
Score = 34.7 bits (78), Expect = 0.14
Identities = 29/142 (20%), Positives = 51/142 (35%), Gaps = 12/142 (8%)
Query: 59 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 118
G WH + S + + VD V+ + I + GG + L
Sbjct: 451 GQWHSVSFSAKWSHMNVVVDDDTAVQPLVA---VLIDSGDTYYFGGCLDNSSGSGCKSPL 507
Query: 119 KPFSGSIQKIILNDRTIH---VKHDFTSG-----VNVENAAHPCVRAPCAHGGSCRPRKE 170
F G ++ I + D+ + V+ ++ C+ + C HGG C +
Sbjct: 508 GGFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWD 567
Query: 171 GYDCDC-PLGFEGLHCQKAIIE 191
+ CDC G+ G C ++ E
Sbjct: 568 TFSCDCLGTGYTGETCHSSLYE 589
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 74.3 bits (181), Expect = 2e-13
Identities = 51/209 (24%), Positives = 89/209 (42%), Gaps = 20/209 (9%)
Query: 5 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR-SEDPLTLGNWHE 63
+ R +G+++Y T + + + + G + F+ DCGSG G+L S + G+WH
Sbjct: 3863 LRLRTLQSNGIIMY---TRANPCIILKIVDGKLWFQLDCGSGPGILGISGRAVNDGSWHS 3919
Query: 64 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVK-----KNSGVL 118
+ + L +D + A F + + I+ G + D+++ + + VL
Sbjct: 3920 VFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVQADNIRSLTDTRVTQVL 3979
Query: 119 KPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAH----------PCVRAPCAHGGSCRPR 168
F G + +ILN+ + +++ +S V C R+PC HGGSC
Sbjct: 3980 SGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLGCVLYPDACKRSPCQHGGSCTGL 4039
Query: 169 KE-GYDCDCPLGFEGLHCQKAIIEAIEIP 196
GY C C F G +C+ I P
Sbjct: 4040 PSGGYQCTCLSQFTGRNCESEITACFPNP 4068
Score = 57.0 bits (136), Expect = 3e-08
Identities = 50/212 (23%), Positives = 87/212 (41%), Gaps = 25/212 (11%)
Query: 153 PCVRAPCAHGGSC---RPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNP 209
PCV PC C + + C CP G G + F G SY+ Y
Sbjct: 3798 PCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLS------FAGNSYIKYRLS 3851
Query: 210 DILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV 269
+ K + +R +T +G++++ +P I L + DG L F + GSG
Sbjct: 3852 ENSKEED---FKLALRLRTLQSNGIIMYTRANPC------IILKIVDGKLWFQLDCGSGP 3902
Query: 270 ASIMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMK 328
+ ++G + NDG WH V + +++DD ++P + L+ ++Y G +
Sbjct: 3903 GILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALV 3962
Query: 329 EI----ALHTNR--QYMRGLVGCISHFTLSTD 354
+ +L R Q + G GC+ L+ +
Sbjct: 3963 QADNIRSLTDTRVTQVLSGFQGCLDSVILNNN 3994
Score = 35.4 bits (80), Expect = 0.084
Identities = 19/63 (30%), Positives = 30/63 (47%), Gaps = 4/63 (6%)
Query: 143 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQF-IGR 201
+GV E + C R C +GGSC + C+C G+ G +C + + +P G
Sbjct: 4091 TGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCG---LRPVVVPNIQAGH 4147
Query: 202 SYL 204
SY+
Sbjct: 4148 SYV 4150
>gi|239743797 PREDICTED: similar to cell recognition molecule CASPR3
[Homo sapiens]
Length = 944
Score = 73.6 bits (179), Expect = 3e-13
Identities = 78/297 (26%), Positives = 123/297 (41%), Gaps = 36/297 (12%)
Query: 17 LYSYDTGSKDFLSINL-AGGHVEFRFDCGSGTG--VLRSEDPLTLGNWHELRVSRTAKNG 73
++ + G DF+ I L A V F FD G+G ++S P WH +R R K
Sbjct: 562 VFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGA 621
Query: 74 ILQVDK--QKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILN 131
LQVD+ QK+ A+G +++ N+ +FIGG + F G I+ + LN
Sbjct: 622 SLQVDQLPQKMQPAPADG-HVRLQLNSQLFIGGTATRQ---------RGFLGCIRSLQLN 671
Query: 132 DRTIHVKHDFT--SGVNVENAAHPCVRAP-CAHGGSCRPRKEGYDCDCPL-GFEGLHCQK 187
+ ++ T GV A H C +GG CR ++ G CDC ++G C
Sbjct: 672 GVALDLEERATVMPGVEPGCAGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSN 731
Query: 188 AI----IEAIEIPQFIGRSYLTYDNPDIL-----KRVSGSRSNVFMRFKTTAKDGLLLWR 238
I + Y +N L + V+ +R + + F+TT LLL+
Sbjct: 732 EISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVTLTREMITLSFRTTRTPSLLLYV 791
Query: 239 GDSPMRPNSDFISLGL-RDGALVFSYNLGSGVASIMVNGSFN---DGRWHRVKAVRD 291
+++S+ L +G+L Y L F DG+ H+VK R+
Sbjct: 792 SSF----YEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMADGQLHQVKINRE 844
Score = 53.1 bits (126), Expect = 4e-07
Identities = 43/138 (31%), Positives = 67/138 (48%), Gaps = 19/138 (13%)
Query: 220 SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALV-FSYNLGSGVASIMVNGS- 277
++V FKTT G+ + +DFI + LR V FS+++G+G + V
Sbjct: 548 ADVCFFFKTTVSSGVFMENLGI-----TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT 602
Query: 278 -FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSP--GMMRQLNINGALYVGGMKEIALHT 334
FND +WH V+A R+ + + VD + +P G +R L +N L++GG
Sbjct: 603 PFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVR-LQLNSQLFIGGT------A 655
Query: 335 NRQYMRGLVGCISHFTLS 352
RQ RG +GCI L+
Sbjct: 656 TRQ--RGFLGCIRSLQLN 671
Score = 33.1 bits (74), Expect = 0.42
Identities = 13/39 (33%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 154 CVRAPCAHGGSCRPRKEGYDCDC-PLGFEGLHCQKAIIE 191
C+ + C HGG C + + CDC G+ G C ++ E
Sbjct: 244 CLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCHSSLYE 282
>gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sapiens]
Length = 1235
Score = 73.6 bits (179), Expect = 3e-13
Identities = 97/388 (25%), Positives = 144/388 (37%), Gaps = 76/388 (19%)
Query: 7 FRPDSGDGVLLYSYDTGSKDFLSINLAGGHV-EFRFDCGSGTGVLRSEDPLTLGN--WHE 63
F+ + GV L + G DF+ I L V F FD G+G + + P + WH
Sbjct: 748 FKTTASSGVFLENL--GIADFIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHH 805
Query: 64 LRVSRTAKNGILQVDK--QKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPF 121
+RV R K LQVD+ K A+G ++ N+ +F+GG + F
Sbjct: 806 VRVERNMKEASLQVDQLTPKTQPAPADG-HVLLQLNSQLFVGGTATRQ---------RGF 855
Query: 122 SGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCA-------HGGSCRPRKEGYDC 174
G I+ + LN T+ D V P R C+ +GG CR R G+ C
Sbjct: 856 LGCIRSLQLNGMTL----DLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRERPIGFFC 911
Query: 175 DCPL-GFEGLHCQKAIIEAIEIPQFIGRS----YLTYDNPDILKRVSG-----------S 218
DC + G C EI + G Y +N + K S S
Sbjct: 912 DCTFSAYTGPFCSN------EISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLS 965
Query: 219 RSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSF 278
R + F+TT LLL+ S I+ ++G+L Y L +VN F
Sbjct: 966 REMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIA---KNGSLQIRYKLNKYQEPDVVNFDF 1022
Query: 279 N---DGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIAL--- 332
DG+ H + R+ I +DD RQ++++ +K + L
Sbjct: 1023 KNMADGQLHHIMINREEGVVFIEIDD---------NRRRQVHLSSGTEFSAVKSLVLGRI 1073
Query: 333 --------HTNRQYMRGLVGCISHFTLS 352
T +G GC+S LS
Sbjct: 1074 LEHSDVDQDTALAGAQGFTGCLSAVQLS 1101
Score = 56.6 bits (135), Expect = 4e-08
Identities = 45/137 (32%), Positives = 66/137 (48%), Gaps = 17/137 (12%)
Query: 220 SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALV-FSYNLGSGVASIMVNGS- 277
++V FKTTA G+ L +DFI + LR +V FS+++G+G I V
Sbjct: 742 ADVSFFFKTTASSGVFLENLGI-----ADFIRIELRSPTVVTFSFDVGNGPFEISVQSPT 796
Query: 278 -FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMR-QLNINGALYVGGMKEIALHTN 335
FND +WH V+ R+ + + VD +T +P L +N L+VGG
Sbjct: 797 HFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGT------AT 850
Query: 336 RQYMRGLVGCISHFTLS 352
RQ RG +GCI L+
Sbjct: 851 RQ--RGFLGCIRSLQLN 865
Score = 45.8 bits (107), Expect = 6e-05
Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 13/116 (11%)
Query: 194 EIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLG 253
E+ G+S L Y K +S + + ++FKT DG+LL R PN D I+L
Sbjct: 157 EVVDLDGKSSLLYRFDQ--KSLSPIKDIISLKFKTMQSDGILLHREG----PNGDHITLQ 210
Query: 254 LRDGALVFSYNLG-------SGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDY 302
LR L N G S + ++ + +D WH V R G+ TVD++
Sbjct: 211 LRRARLFLLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 266
Score = 39.3 bits (90), Expect = 0.006
Identities = 43/154 (27%), Positives = 64/154 (41%), Gaps = 11/154 (7%)
Query: 201 RSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALV 260
RSYL + + VS + +F+T K GLLL+ S ++ S I L L DG L
Sbjct: 305 RSYLALPDFSGEEEVSAT-----FQFRTWNKAGLLLF---SELQLISGGILLFLSDGKLK 356
Query: 261 FS-YNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNIN 319
+ Y G + I NDG+WH V + VD A G Q+
Sbjct: 357 SNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLG-PEQIYSG 415
Query: 320 GALYVGGMKEIALHTN-RQYMRGLVGCISHFTLS 352
G Y GG + + + + + G GC+ ++S
Sbjct: 416 GTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISIS 449
Score = 39.3 bits (90), Expect = 0.006
Identities = 32/142 (22%), Positives = 56/142 (39%), Gaps = 10/142 (7%)
Query: 59 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 118
G WH + +S + + VD Q + G QI + GG P+ K L
Sbjct: 378 GQWHSVSLSAKKNHLSVAVDGQ-MASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPL 436
Query: 119 KPFSGSIQKIILNDRTIHV------KHDFTSGVNVENA--AHPCVRAPCAHGGSCRPRKE 170
F G ++ I ++ + + + S + +++ + C+ C HGG C
Sbjct: 437 GGFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWS 496
Query: 171 GYDCDCP-LGFEGLHCQKAIIE 191
+ C+C G+ G C +I E
Sbjct: 497 TFHCNCTNTGYRGATCHNSIYE 518
>gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sapiens]
Length = 1308
Score = 73.6 bits (179), Expect = 3e-13
Identities = 97/388 (25%), Positives = 144/388 (37%), Gaps = 76/388 (19%)
Query: 7 FRPDSGDGVLLYSYDTGSKDFLSINLAGGHV-EFRFDCGSGTGVLRSEDPLTLGN--WHE 63
F+ + GV L + G DF+ I L V F FD G+G + + P + WH
Sbjct: 821 FKTTASSGVFLENL--GIADFIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHH 878
Query: 64 LRVSRTAKNGILQVDK--QKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPF 121
+RV R K LQVD+ K A+G ++ N+ +F+GG + F
Sbjct: 879 VRVERNMKEASLQVDQLTPKTQPAPADG-HVLLQLNSQLFVGGTATRQ---------RGF 928
Query: 122 SGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCA-------HGGSCRPRKEGYDC 174
G I+ + LN T+ D V P R C+ +GG CR R G+ C
Sbjct: 929 LGCIRSLQLNGMTL----DLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRERPIGFFC 984
Query: 175 DCPL-GFEGLHCQKAIIEAIEIPQFIGRS----YLTYDNPDILKRVSG-----------S 218
DC + G C EI + G Y +N + K S S
Sbjct: 985 DCTFSAYTGPFCSN------EISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLS 1038
Query: 219 RSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSF 278
R + F+TT LLL+ S I+ ++G+L Y L +VN F
Sbjct: 1039 REMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIA---KNGSLQIRYKLNKYQEPDVVNFDF 1095
Query: 279 N---DGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIAL--- 332
DG+ H + R+ I +DD RQ++++ +K + L
Sbjct: 1096 KNMADGQLHHIMINREEGVVFIEIDD---------NRRRQVHLSSGTEFSAVKSLVLGRI 1146
Query: 333 --------HTNRQYMRGLVGCISHFTLS 352
T +G GC+S LS
Sbjct: 1147 LEHSDVDQDTALAGAQGFTGCLSAVQLS 1174
Score = 56.6 bits (135), Expect = 4e-08
Identities = 45/137 (32%), Positives = 66/137 (48%), Gaps = 17/137 (12%)
Query: 220 SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALV-FSYNLGSGVASIMVNGS- 277
++V FKTTA G+ L +DFI + LR +V FS+++G+G I V
Sbjct: 815 ADVSFFFKTTASSGVFLENLGI-----ADFIRIELRSPTVVTFSFDVGNGPFEISVQSPT 869
Query: 278 -FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMR-QLNINGALYVGGMKEIALHTN 335
FND +WH V+ R+ + + VD +T +P L +N L+VGG
Sbjct: 870 HFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGT------AT 923
Query: 336 RQYMRGLVGCISHFTLS 352
RQ RG +GCI L+
Sbjct: 924 RQ--RGFLGCIRSLQLN 938
Score = 47.0 bits (110), Expect = 3e-05
Identities = 83/359 (23%), Positives = 136/359 (37%), Gaps = 57/359 (15%)
Query: 5 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPL---TLGN- 60
+ F+ DG+LL+ + + D +++ L + + SG L S L TLG+
Sbjct: 210 LKFKTMQSDGILLHR-EGPNGDHITLQLRRARLFLLIN--SGEAKLPSTSTLVNLTLGSL 266
Query: 61 -----WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 115
WH + + R K VD+ + A G F + + +I GG+P K S
Sbjct: 267 LDDQHWHSVLIQRLGKQVNFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPG--KSVS 323
Query: 116 GVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCD 175
+ F G ++ + N GV++ + A A G + C
Sbjct: 324 FPHRNFHGCLENLYYN------------GVDIIDLAKQQKPQIIAMGNV------SFSCS 365
Query: 176 CPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLL 235
P +++ + RSYL + + VS + +F+T K GLL
Sbjct: 366 QP-------------QSMPVTFLSSRSYLALPDFSGEEEVSAT-----FQFRTWNKAGLL 407
Query: 236 LWRGDSPMRPNSDFISLGLRDGALVFS-YNLGSGVASIMVNGSFNDGRWHRVKAVRDGQS 294
L+ S ++ S I L L DG L + Y G + I NDG+WH V
Sbjct: 408 LF---SELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNH 464
Query: 295 GKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTN-RQYMRGLVGCISHFTLS 352
+ VD A G Q+ G Y GG + + + + + G GC+ ++S
Sbjct: 465 LSVAVDGQMASAAPLLG-PEQIYSGGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISIS 522
Score = 46.2 bits (108), Expect = 5e-05
Identities = 39/141 (27%), Positives = 62/141 (43%), Gaps = 14/141 (9%)
Query: 194 EIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLG 253
E+ G+S L Y K +S + + ++FKT DG+LL R PN D I+L
Sbjct: 182 EVVDLDGKSSLLYRFDQ--KSLSPIKDIISLKFKTMQSDGILLHREG----PNGDHITLQ 235
Query: 254 LRDGALVFSYNLG-------SGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGART 306
LR L N G S + ++ + +D WH V R G+ TVD++
Sbjct: 236 LRRARLFLLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH-RHH 294
Query: 307 GKSPGMMRQLNINGALYVGGM 327
+ G +N++ + GG+
Sbjct: 295 FHARGEFNLMNLDYEISFGGI 315
Score = 39.3 bits (90), Expect = 0.006
Identities = 32/142 (22%), Positives = 56/142 (39%), Gaps = 10/142 (7%)
Query: 59 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 118
G WH + +S + + VD Q + G QI + GG P+ K L
Sbjct: 451 GQWHSVSLSAKKNHLSVAVDGQ-MASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPL 509
Query: 119 KPFSGSIQKIILNDRTIHV------KHDFTSGVNVENA--AHPCVRAPCAHGGSCRPRKE 170
F G ++ I ++ + + + S + +++ + C+ C HGG C
Sbjct: 510 GGFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWS 569
Query: 171 GYDCDCP-LGFEGLHCQKAIIE 191
+ C+C G+ G C +I E
Sbjct: 570 TFHCNCTNTGYRGATCHNSIYE 591
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 72.8 bits (177), Expect = 5e-13
Identities = 94/393 (23%), Positives = 165/393 (41%), Gaps = 70/393 (17%)
Query: 5 ITFRPDSGDGVLLYSYDTGSK-DFLSINLAGGHVEFRFDCGSGTGVLRSEDP--LTLGNW 61
+TF +G+LLY+ K DF+++ + V+ F G T + + P ++ G W
Sbjct: 1468 LTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRW 1527
Query: 62 HELRVSRTAKNGILQV--------DKQKIV------------------------EGMAEG 89
H ++V K I + +K +V +G G
Sbjct: 1528 HSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTG 1587
Query: 90 GFTQIKCNTDIFIGGVPNY-DDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVE 148
+ + +GGVPN +D ++ + F G ++ + ++ + + + + E
Sbjct: 1588 SKKSLDLTGPLLLGGVPNLPEDFPVHN---RQFVGCMRNLSVDGKNVDMAGFIANNGTRE 1644
Query: 149 NAA---HPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQ-FIGRSYL 204
A + C C +GG+C R Y C+CPL F G +C+ +A+ PQ F G S +
Sbjct: 1645 GCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCE----QAMPHPQLFSGESVV 1700
Query: 205 TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN 264
++ + +I+ V + + F+T +D +L+ P S L + + L F +
Sbjct: 1701 SWSDLNIIISVPW---YLGLMFRTRKEDSVLMEATSG--GPTS--FRLQILNNYLQFEVS 1753
Query: 265 LG-SGVASIMVNG-SFNDGRWH----RVKAVRDGQSGKITVD---DYGARTGKSP--GMM 313
G S V S+M++G DG WH +K V++ K V DYG K+ GM+
Sbjct: 1754 HGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGML 1813
Query: 314 RQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 346
L + ++ VGG E + RG GC+
Sbjct: 1814 PGLTVR-SVVVGGASEDKVSVR----RGFRGCM 1841
Score = 62.8 bits (151), Expect = 5e-10
Identities = 73/292 (25%), Positives = 115/292 (39%), Gaps = 95/292 (32%)
Query: 154 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIE--------------IPQFI 199
C PC G CR R+ GY C+C F G HC+ ++A + I
Sbjct: 1367 CYSDPCGANGRCRSREGGYTCECFEDFTGEHCE---VDARSGRCANGVCKNGGTCVNLLI 1423
Query: 200 GRSYLT-----YDNP--DILKRVSGSRSNVFMR-------------FKTTAKDGLLLWRG 239
G + Y+ P ++ R +S V R F T ++GLLL+ G
Sbjct: 1424 GGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNG 1483
Query: 240 DSPMRPNSDFISLGLRDGALVFSYNLGSGVASIM--VNGSFNDGRWHRVK---------- 287
DFI+L + D + +++ G ++ V +DGRWH V+
Sbjct: 1484 R--FNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIG 1541
Query: 288 --AVRDGQSGK----ITVDD--------YG--------ARTGKSPGMMRQLNINGALYVG 325
+ G SG+ +TVDD +G A G G + L++ G L +G
Sbjct: 1542 HLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLG 1601
Query: 326 GM----KEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCG 373
G+ ++ +H NRQ+ VGC+ + +VDGKN++ G
Sbjct: 1602 GVPNLPEDFPVH-NRQF----VGCMRNL-------------SVDGKNVDMAG 1635
Score = 43.5 bits (101), Expect = 3e-04
Identities = 45/202 (22%), Positives = 76/202 (37%), Gaps = 26/202 (12%)
Query: 5 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGT--GVLRSEDPLTLGNWH 62
+ FR D VL+ + G F + + +++F G V+ S +T G WH
Sbjct: 1717 LMFRTRKEDSVLMEATSGGPTSF-RLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWH 1775
Query: 63 ELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV-----KKNSGV 117
L + KN + + +V + G Q K + + G+ V + V
Sbjct: 1776 HLLIE--LKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDKVSV 1833
Query: 118 LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAH-----------PCVRAPCAHGGSCR 166
+ F G +Q + + +V + +N+ NA PC +PC C
Sbjct: 1834 RRGFRGCMQGVRMGGTPTNV-----ATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCH 1888
Query: 167 PRKEGYDCDCPLGFEGLHCQKA 188
E Y C C G+ G++C A
Sbjct: 1889 DAWEDYSCVCDKGYLGINCVDA 1910
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 72.8 bits (177), Expect = 5e-13
Identities = 49/204 (24%), Positives = 86/204 (42%), Gaps = 18/204 (8%)
Query: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSED-PLTLG 59
M+ + R S V++Y+ T D+ + + G ++++FDCGSG G++ + + G
Sbjct: 3853 MKLTMRLRTYSTHAVVMYARGT---DYSILEIHHGRLQYKFDCGSGPGIVSVQSIQVNDG 3909
Query: 60 NWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVK--KNSGV 117
WH + + L +D+ G A G + + +F GG + ++ V
Sbjct: 3910 QWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQGTRHGRSPQV 3969
Query: 118 LKPFSGSIQKIILNDRTIHVKHDFTSGVNVE-----------NAAHPCVRAPCAHGGSCR 166
F G + I LN + + + S ++E A C PC +GG C
Sbjct: 3970 GNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASNPCQNGGVCN 4029
Query: 167 PRKE-GYDCDCPLGFEGLHCQKAI 189
P GY C C + G HC+ ++
Sbjct: 4030 PSPAGGYYCKCSALYIGTHCEISV 4053
Score = 65.9 bits (159), Expect = 6e-11
Identities = 52/208 (25%), Positives = 92/208 (44%), Gaps = 23/208 (11%)
Query: 152 HPCVRAPCAHGGSC--RPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNP 209
H C PC G C P +E + C CP G G C + + G SY+ Y
Sbjct: 3792 HGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFG-QCPGSSSMTLT-----GNSYVKYR-- 3843
Query: 210 DILKRVSGSRSNVFMRFKTTAKDGLLLW-RGDSPMRPNSDFISLGLRDGALVFSYNLGSG 268
+ + + + MR +T + ++++ RG +D+ L + G L + ++ GSG
Sbjct: 3844 -LTENENKLEMKLTMRLRTYSTHAVVMYARG-------TDYSILEIHHGRLQYKFDCGSG 3895
Query: 269 VASIMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG- 326
+ V NDG+WH V +G ++ +D +G +PG ++ LN++ ++ GG
Sbjct: 3896 PGIVSVQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGH 3955
Query: 327 MKEIALHTNR--QYMRGLVGCISHFTLS 352
+++ R Q G GC+ L+
Sbjct: 3956 IRQQGTRHGRSPQVGNGFRGCMDSIYLN 3983
Score = 37.7 bits (86), Expect = 0.017
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 154 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIE 191
C PC +GG+C +G C C GF G CQ I E
Sbjct: 4093 CKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDE 4130
Score = 36.2 bits (82), Expect = 0.049
Identities = 14/45 (31%), Positives = 19/45 (42%)
Query: 144 GVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKA 188
G ++ C PC HG C Y C+C + G HC+ A
Sbjct: 4121 GERCQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDA 4165
>gi|219842266 usherin isoform B [Homo sapiens]
Length = 5202
Score = 68.6 bits (166), Expect = 9e-12
Identities = 91/392 (23%), Positives = 167/392 (42%), Gaps = 72/392 (18%)
Query: 6 TFRPDSGDGVLLYSYDTGSKD-FLSINLAGGHVEFRFDC-GSGTGVLRSED---PLTLGN 60
+FR +G+++++ G+++ + ++ L G + F FD GS V + D + G
Sbjct: 1547 SFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGK 1606
Query: 61 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVP-NYDDVKKNSGVL- 118
WHE+ R G + +D G T I NT +F+GG+P +Y ++K+ ++
Sbjct: 1607 WHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQ 1666
Query: 119 KPFSGSIQKIIL----NDRTIHVKHDFTSG---VNVENAAHPCVRAPCAHGGSCRPRKEG 171
K F G ++ + N I D+ S +NV N+ EG
Sbjct: 1667 KGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNS------------------WEG 1708
Query: 172 YDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAK 231
CP E QF+G +L +P + G + +F+T
Sbjct: 1709 ----CPASLN------------EGAQFLGAGFLEL-HPYMFH--GGMNFEISFKFRTDQL 1749
Query: 232 DGLLL--WRGDSPMRPNSDFISLGLRDGALVFSYN--LGSGVASIMVNGSFNDGRWHRVK 287
+GLLL + D P DF+++ L+ G L F N L +++ S+ +G+W++V
Sbjct: 1750 NGLLLFVYNKDGP-----DFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKWNKVI 1804
Query: 288 AVRDGQSGKITVD---DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYM--RGL 342
++G +V+ + + +G P L +N +YVGG+ + L++ + +G
Sbjct: 1805 IKKEGSFISASVNGLMKHASESGDQP-----LVVNSPVYVGGIPQELLNSYQHLCLEQGF 1859
Query: 343 VGCIS--HFTLSTDYHISLVEDAVDGKNINTC 372
GC+ FT +++ V N++ C
Sbjct: 1860 GGCMKDVKFTRGAVVNLASVSSGAVRVNLDGC 1891
Score = 53.5 bits (127), Expect = 3e-07
Identities = 47/178 (26%), Positives = 82/178 (46%), Gaps = 15/178 (8%)
Query: 197 QFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRD 256
+FIG Y + P V+ + + F+T +GL+++ SP ++ +L L+
Sbjct: 1521 RFIGNGYCKF--PSSTHPVNTDFTGIKASFRTKVPEGLIVFAA-SPGN-QEEYFALQLKK 1576
Query: 257 GALVFSYN-LGSGVASIMVNG---SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGM 312
G L F ++ GS V N ++DG+WH + A+R G+IT+D G TG S +
Sbjct: 1577 GRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLD--GIYTGSSAIL 1634
Query: 313 MRQLNI--NGALYVGGMKE---IALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVD 365
I N +++GG+ I +G VGC+ +Y+ S + + +D
Sbjct: 1635 NGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPLD 1692
Score = 45.4 bits (106), Expect = 8e-05
Identities = 29/114 (25%), Positives = 58/114 (50%), Gaps = 14/114 (12%)
Query: 1 MEFEITF--RPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 58
M FEI+F R D +G+LL+ Y+ DFL++ L G + FR + T + ++ L L
Sbjct: 1736 MNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLN----TSLAFTQVDLLL 1791
Query: 59 ------GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVP 106
G W+++ + + + + +++ +E G + N+ +++GG+P
Sbjct: 1792 GLSYCNGKWNKVIIKK--EGSFISASVNGLMKHASESGDQPLVVNSPVYVGGIP 1843
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.139 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,386,343
Number of Sequences: 37866
Number of extensions: 655489
Number of successful extensions: 2586
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 99
Number of HSP's successfully gapped in prelim test: 60
Number of HSP's that attempted gapping in prelim test: 1553
Number of HSP's gapped (non-prelim): 855
length of query: 375
length of database: 18,247,518
effective HSP length: 104
effective length of query: 271
effective length of database: 14,309,454
effective search space: 3877862034
effective search space used: 3877862034
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.