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Search of human proteins with 122937396
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937396 coiled-coil domain containing 150 [Homo sapiens]
(1101 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937396 coiled-coil domain containing 150 [Homo sapiens] 2117 0.0
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 161 4e-39
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 157 5e-38
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 157 5e-38
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 157 5e-38
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 156 9e-38
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 156 9e-38
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 156 1e-37
gi|71061468 centromere protein E [Homo sapiens] 155 2e-37
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 155 3e-37
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 153 1e-36
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 152 1e-36
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 151 4e-36
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 149 1e-35
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 149 1e-35
gi|156104908 myosin heavy chain 6 [Homo sapiens] 149 1e-35
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 147 5e-35
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 146 9e-35
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 146 9e-35
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 146 9e-35
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 146 9e-35
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 146 9e-35
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 146 9e-35
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 146 9e-35
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 146 9e-35
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 146 9e-35
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 146 9e-35
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 145 3e-34
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 145 3e-34
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 144 6e-34
>gi|122937396 coiled-coil domain containing 150 [Homo sapiens]
Length = 1101
Score = 2117 bits (5486), Expect = 0.0
Identities = 1101/1101 (100%), Positives = 1101/1101 (100%)
Query: 1 MDCKVHMETTVSRPVLSPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRG 60
MDCKVHMETTVSRPVLSPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRG
Sbjct: 1 MDCKVHMETTVSRPVLSPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRG 60
Query: 61 YLEAPDCLEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFR 120
YLEAPDCLEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFR
Sbjct: 61 YLEAPDCLEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFR 120
Query: 121 LQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQR 180
LQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQR
Sbjct: 121 LQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQR 180
Query: 181 LTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLK 240
LTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLK
Sbjct: 181 LTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLK 240
Query: 241 IQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSR 300
IQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSR
Sbjct: 241 IQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSR 300
Query: 301 DDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCML 360
DDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCML
Sbjct: 301 DDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCML 360
Query: 361 QTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAH 420
QTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAH
Sbjct: 361 QTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAH 420
Query: 421 LDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQRE 480
LDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQRE
Sbjct: 421 LDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQRE 480
Query: 481 VNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYH 540
VNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYH
Sbjct: 481 VNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYH 540
Query: 541 GLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYA 600
GLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYA
Sbjct: 541 GLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYA 600
Query: 601 QANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVED 660
QANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVED
Sbjct: 601 QANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVED 660
Query: 661 RENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKK 720
RENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKK
Sbjct: 661 RENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKK 720
Query: 721 ERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQ 780
ERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQ
Sbjct: 721 ERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQ 780
Query: 781 TNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERE 840
TNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERE
Sbjct: 781 TNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERE 840
Query: 841 TTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIK 900
TTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIK
Sbjct: 841 TTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIK 900
Query: 901 LHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQM 960
LHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQM
Sbjct: 901 LHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQM 960
Query: 961 LAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVE 1020
LAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVE
Sbjct: 961 LAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVE 1020
Query: 1021 SEQITANLEEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDVKHDVMSNQSVLHR 1080
SEQITANLEEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDVKHDVMSNQSVLHR
Sbjct: 1021 SEQITANLEEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDVKHDVMSNQSVLHR 1080
Query: 1081 WERKQNLRPMPKKYHSEVQRK 1101
WERKQNLRPMPKKYHSEVQRK
Sbjct: 1081 WERKQNLRPMPKKYHSEVQRK 1101
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 161 bits (407), Expect = 4e-39
Identities = 253/1163 (21%), Positives = 483/1163 (41%), Gaps = 174/1163 (14%)
Query: 38 IVEEQTSSLRDDLIMLDFGEKRGYL---EAPDCLEDLDSQKVISPIQNEAICAGKTDILW 94
++EE +I + RG L E LE DS VI N G + W
Sbjct: 772 LLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQ--WNIRAFMGVKNWPW 829
Query: 95 KNCEFLVNRMCRL---ESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLK 151
F + + + E M S+K RL+ + + + L++++ ++ +E +
Sbjct: 830 MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND--- 886
Query: 152 LLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNL 211
L L+V + L +E D+ +L A +K ++ ++ + EL KRK+
Sbjct: 887 -LQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED 945
Query: 212 KIQELRRQL----------AQEKYLRESLEKSASAMLLKIQEMGSTVEVERK-------- 253
+ EL+R + +EK+ E+ K+ + + + E+ + + E+K
Sbjct: 946 ECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1005
Query: 254 ----------QVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDL 303
+V+ L + + L + + L QE+K + +LE A +L+ DL +
Sbjct: 1006 ALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1065
Query: 304 ISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTV 363
I L + + L K+ E+ +L+ E Q L QL KK EL ++ +
Sbjct: 1066 IMDLENDKQQLDERLKKKD-------FELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 364 TMEKARIIADHQAILQVE--QKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQ--- 418
E + A+ A +VE + +++ +E + L+ A + + +++ + + + Q
Sbjct: 1119 EEE---LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMR 1175
Query: 419 AHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQ 478
L+ L+H E A ++ ++A L +++ + K+ L +EK F+
Sbjct: 1176 RDLEEATLQH----------EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1225
Query: 479 RE---VNKTEKEIVQERCNLEK--------------ELAKNKVDINTLTHNLQTLEEENK 521
E V ++I++ + NLEK + + + +N LT L+ EN
Sbjct: 1226 LELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENG 1285
Query: 522 HLADQMASLE--LQQVTSDYHGLAQQ------KVEKITESKNKLAYENGKLQIKVKQLEE 573
L+ Q+ E + Q+T QQ ++E+ ++KN LA+ + L E
Sbjct: 1286 ELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLRE 1345
Query: 574 QVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQ----QADAHLKEVKSILER 629
Q + T+ + LQ ++ANSE++ R + Q L+E K L +
Sbjct: 1346 QYEEETEAKAE----------LQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1395
Query: 630 SKEELSRTVKCRNAALKESQKLK-------EDLEAVEDREN-------KKVGNFQRQLAE 675
+E V+ NA +K K EDL +R N KK NF + LAE
Sbjct: 1396 RLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAE 1455
Query: 676 AKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAE 735
K+ + + Q LE Q E +E+ LK + + + ++ + E
Sbjct: 1456 WKQ--------------KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1501
Query: 736 VDQWQARMLVMEDQHNSE---IESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHI 792
Q + + +Q S I L+K + +L +LE+A + H + K+ +
Sbjct: 1502 NKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI--L 1559
Query: 793 QEQLE----SKELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQR 848
+ QLE E+ER+ E KD E++K H +++L+ E ++
Sbjct: 1560 RAQLEFNQIKAEIERKLAE--KDEEMEQAK---RNHLRVVDSLQTSLDAETR-----SRN 1609
Query: 849 EVAELKKALD-EANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKA 907
E +KK ++ + N +++S NR AE +K ++S + +K+ TQI+L + +A
Sbjct: 1610 EALRVKKKMEGDLNEMEIQLSHANR----MAAEAQKQVKSLQSLLKD--TQIQLDDAVRA 1663
Query: 908 NN--AQNI----ERMKQIEKELKQMELIKDQYQ--KKNYEQSLSIQRFVCEMTNLQKEMQ 959
N+ +NI R ++ EL+++ + +Q + +K EQ L ++ + Q
Sbjct: 1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1723
Query: 960 MLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASV 1019
+ K + DA + Q E+ EA ++ R E + + + ++ K+ ++ S
Sbjct: 1724 INQKKKMDADLSQLQTEVE-EAVQECRNAEEKAKKAITDAAMMAEELKKE-----QDTSA 1777
Query: 1020 ESEQITANLEEAHRWFKHRFD-GLQLELTKNRLQRPSGEDRWQEKDQDVKHDVMSNQSVL 1078
E++ N+E+ + +HR D Q+ L + Q E R +E + +++ + N +
Sbjct: 1778 HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESV 1837
Query: 1079 HRWERKQNLRPMPKKYHSEVQRK 1101
+ RK R Y +E RK
Sbjct: 1838 -KGMRKSERRIKELTYQTEEDRK 1859
Score = 149 bits (375), Expect = 2e-35
Identities = 227/1068 (21%), Positives = 461/1068 (43%), Gaps = 158/1068 (14%)
Query: 95 KNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLH 154
+ C+ L+ +LE+ ++ + RL+ E+++N + TA + +++E S+ L
Sbjct: 903 ERCDQLIKNKIQLEAKVKEMNE---RLEDEEEMNAELTA----KKRKLEDECSE----LK 951
Query: 155 LEVMNLRQQLRAVKEEEDKAQDEVQRLTATLK-----IASQTKKNAAIIEEE-------- 201
++ +L L V++E+ +++V+ LT + IA TK+ A+ E
Sbjct: 952 RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1011
Query: 202 --------LKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAM---LLKIQEMGSTVEV 250
L K K+ ++ +L L QEK +R LE++ + L QE +E
Sbjct: 1012 AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN 1071
Query: 251 ERKQVHILQQN----CIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISK 306
+++Q+ + AL I+ Q L +Q QKK +EL+ +L+ +L + +K
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 1131
Query: 307 LVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTME 366
+ + L+ ++E EE + L EA V + K+ +E M + +E
Sbjct: 1132 V----EKLRSDLSRELEEISE------RLEEAGGATSVQIEMNKKREAEFQKMRRD--LE 1179
Query: 367 KARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLIL 426
+A + H+A +K + E +D ++ Q ++ EK++ + LD +
Sbjct: 1180 EATL--QHEATAAALRKKHADSVAELGEQID----NLQRVKQKLEKEKSEFKLELDDVTS 1233
Query: 427 EHNQCIQKAQDAEKRTAVQKELLE-------------STIARLRGELEASMQEKKSLLEE 473
Q I+ + EK ++ + + + R +L+ E L+E
Sbjct: 1234 NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE 1293
Query: 474 KERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQM-----A 528
KE ++ + + Q+ +L+++L + N L H LQ+ + L +Q A
Sbjct: 1294 KEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEA 1353
Query: 529 SLELQQVTSD-----------YHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQS 577
ELQ+V S Y A Q+ E++ E+K KLA ++++ EE V++
Sbjct: 1354 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ-------RLQEAEEAVEA 1406
Query: 578 FTD--TSLQNDHLRKMNKY--LQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEE 633
+SL+ R N+ L ++N+ +A + D L E K E S+ E
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Query: 634 LSRTVKCRNAALKESQKLK----EDLEAVED--RENKKVGNFQRQLAEAKEDNCKVTIML 687
L + K + E KLK E LE +E RENK + L E + K L
Sbjct: 1467 LESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHEL 1526
Query: 688 ENVL----ASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARM 743
E V A ++Q ALE+ + L + +I L+ + + NQ + + +E ++ + M
Sbjct: 1527 EKVRKQLEAEKMELQSALEEAEASLEHEEGKI--LRAQLEFNQIKAE-IERKLAEKDEEM 1583
Query: 744 LVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTN-NHLQTKLDHIQEQLESKELE 802
+ H ++SLQ +L A +R A+ +++ ++ + N ++ +L H + +
Sbjct: 1584 EQAKRNHLRVVDSLQTSLD-AETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQ 1642
Query: 803 RQNLETF-KD---------RMTEESKVEAELHAERIEALRKQFQTER------ETTKKVA 846
++L++ KD R ++ K + R L+ + + R E ++K+A
Sbjct: 1643 VKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA 1702
Query: 847 QREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAK 906
++E+ E + + + ++ + +++ L++L+ +E ++ +N + + K ++
Sbjct: 1703 EQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDA 1762
Query: 907 ANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQY 966
A A+ +++ + L++M KKN EQ++ K++Q
Sbjct: 1763 AMMAEELKKEQDTSAHLERM--------KKNMEQTI-------------KDLQHRLDEAE 1801
Query: 967 DASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITA 1026
+++ +++L + E ++R ELEN + ++ K +E +KE + ++E+
Sbjct: 1802 QIALKGGKKQLQ-KLEARVR-ELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRK 1859
Query: 1027 NLEEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQ---EKDQDVKHDV 1071
NL + D LQL++ + Q E++ K + V+H++
Sbjct: 1860 NLLR----LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1903
Score = 94.4 bits (233), Expect = 5e-19
Identities = 139/642 (21%), Positives = 276/642 (42%), Gaps = 54/642 (8%)
Query: 132 TAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQ---LRAVKEEEDKAQDEVQRLT--ATLK 186
T L+D ++EE L H + + R LR EEE +A+ E+QR+ A +
Sbjct: 1309 TQQLEDLKRQLEEEVKAKNALAHA-LQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1367
Query: 187 IAS-QTKKNAAIIE--EELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQE 243
+A +TK I+ EEL+ K+K+ ++QE + SLEK+ + +I++
Sbjct: 1368 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED 1427
Query: 244 MGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDL 303
+ V+VER AL ++ ++LA+ ++K EE + + + S
Sbjct: 1428 L--MVDVERSNAA-----AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1480
Query: 304 ISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTV 363
+ KL + EN L+ EI L E + +L K +L +
Sbjct: 1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL----EAE 1536
Query: 364 TMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDH 423
ME + + +A L+ E+ + + E N + A I +L + ++ QA +H
Sbjct: 1537 KMELQSALEEAEASLEHEEGKILRAQLEFNQI----KAEIERKL--AEKDEEMEQAKRNH 1590
Query: 424 LILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNK 483
L + + +Q + DAE R+ + R++ ++E + E + L R E K
Sbjct: 1591 LRVVDS--LQTSLDAETRS-------RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQK 1641
Query: 484 TEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLE-LQQVTSDYHGL 542
K + + + +L + L N+ +E N L ++ L + + T L
Sbjct: 1642 QVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL 1701
Query: 543 AQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQA 602
A+Q++ + +E L +N L + K+++ + T ++ N + K A
Sbjct: 1702 AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQL-QTEVEEAVQECRNAEEKAKKAIT 1760
Query: 603 NSELSAKRVHLQQ-ADAHLKEVKSILERSKEELS-RTVKCRNAALKESQK---------- 650
++ + A+ + +Q AHL+ +K +E++ ++L R + ALK +K
Sbjct: 1761 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1820
Query: 651 -LKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELG 709
L+ +LEA + R + V ++ KE +T E + ++Q ++K+Q+++
Sbjct: 1821 ELENELEAEQKRNAESVKGMRKSERRIKE----LTYQTEEDRKNLLRLQDLVDKLQLKVK 1876
Query: 710 RRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHN 751
+ +++ + N + +K++ E+D+ + R + E Q N
Sbjct: 1877 AYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1918
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 157 bits (397), Expect = 5e-38
Identities = 239/1106 (21%), Positives = 466/1106 (42%), Gaps = 152/1106 (13%)
Query: 33 QQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQNEAICAGKTDI 92
++ M ++E+ +D+L + K E + L L +K +Q +A D
Sbjct: 847 EKEMATMKEEFQKTKDELAKSEAKRK----ELEEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 93 LWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKL 152
+ C+ L+ +LE+ ++ + R + E+++N + TA K +L E KD+
Sbjct: 903 E-ERCDQLIKAKFQLEAKIKEVTE---RAEDEEEINAELTA-KKRKLEDECSELKKDIDD 957
Query: 153 LHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLK 212
L L + + ++ A + + +E+ L T IA T++ A+ E
Sbjct: 958 LELTLAKVEKEKHATENKVKNLTEELSGLDET--IAKLTREKKALQEAH----------- 1004
Query: 213 IQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSA 272
Q+ L E+ SL K+ S + +++++ S++E E+K L++N L ++ A
Sbjct: 1005 -QQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLA 1063
Query: 273 QELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEI 332
QE + + K++L+ +LK L SK VE+ + L + F K+ +E L++ I
Sbjct: 1064 QESILDLENDKQQLD---ERLKKKDFEYCQLQSK-VEDEQTLGLQFQKKIKE---LQARI 1116
Query: 333 MSLHEASEKAQVLNDQLTKKCSELSCMLQTVT--MEKARIIADHQA---------ILQVE 381
L E E + + K+ S+ + L+ ++ +E+A + Q L++
Sbjct: 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR 1176
Query: 382 QKMMTQTFQEQNLL--LDAAHASITNEL-----------QTVQNEKTQLQAHLDHLILEH 428
+ + T Q + ++ L HA EL Q ++ EK++ + +D L
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236
Query: 429 NQCIQKAQDAEK---------------RTAVQKELLESTIARLRGELEASMQEKKSLLEE 473
+ + EK +Q+ L E T + R + EA E LEE
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG--ELSRQLEE 1294
Query: 474 KERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQT-----------LEEENKH 522
KE +++++++ Q+ L+++L + N L H LQ+ EEE +
Sbjct: 1295 KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG 1354
Query: 523 LADQMASL-----ELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQS 577
A+ +L E+ Q + Y A Q+ E++ E+K KLA +LQ +Q+E
Sbjct: 1355 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ---RLQDSEEQVEAVNAK 1411
Query: 578 FTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRT 637
L+ + L +ANS +A + D L E K+ E S+ EL +
Sbjct: 1412 CASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAS 1471
Query: 638 VKCRNAALKESQKLKEDLEAVED------RENKKVGNFQRQLAEAKEDNCKVTIMLENVL 691
+K + E KLK E D RENK + L E +N K LE
Sbjct: 1472 LKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEK-- 1529
Query: 692 ASHSKMQGALEKVQIELGRRDSEIAG-------LKKERDLNQ------QRVQKLEAEVDQ 738
S+ Q LEK I+L ++E A L+ + +L Q +++ + + E++Q
Sbjct: 1530 ---SRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQ 1586
Query: 739 ----WQARMLVMEDQHNSEIESLQKAL-------GVAREDNRKLAMSLEQALQTNNHLQT 787
+Q + M+ ++E+ S +A+ G E +L+ + QA +T HL++
Sbjct: 1587 LKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRS 1646
Query: 788 KLDHIQEQLESKELERQNLETFKDRMTEESKV---EAELHAERIEALRKQFQTERETTKK 844
+Q QL+ +L + ++ + E+ + A L +E LR + + E +K
Sbjct: 1647 ----VQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLE-QTERARK 1701
Query: 845 VAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLS 904
+A++E+ + + + + ++ + T ++L L +L+ +E +N + + K ++
Sbjct: 1702 LAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAIT 1761
Query: 905 AKANNAQNIERMKQIEKELKQM-----ELIKDQYQKKNYEQSLS-------IQRFVCEMT 952
A A+ +++ + L++M + +KD + + + L+ IQ+ +
Sbjct: 1762 DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIR 1821
Query: 953 NLQKEMQMLAKSQYDA-------SVRNKQQELHLEAERKIRQELENRCQELEETVRHLKK 1005
L+ E++ K ++ R K+ E +RK L++ +L+ V+ K+
Sbjct: 1822 ELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKR 1881
Query: 1006 CKEATENTLKEASVESEQITANLEEA 1031
E + + + LEEA
Sbjct: 1882 QAEEADEQANAHLTKFRKAQHELEEA 1907
Score = 148 bits (374), Expect = 2e-35
Identities = 234/1064 (21%), Positives = 466/1064 (43%), Gaps = 132/1064 (12%)
Query: 122 QTEKDLNPQKTAF--LKDRL---NAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQD 176
+TEK++ K F KD L A ++E + L L E +L+ Q++A E A++
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 177 EVQRLT-------ATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRES 229
+L A +K ++ ++ I EL KRK+ + EL++ + +
Sbjct: 905 RCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964
Query: 230 LEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIA 289
+EK A K++ + + + + L + AL+++ Q A + L E+ K L
Sbjct: 965 VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024
Query: 290 TSQLKSDLTSRDDLISKLVEENK-NLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQ 348
S+L+ + +DL S L +E K + + NK E L+ S+ + Q L+++
Sbjct: 1025 KSKLEQQV---EDLESSLEQEKKLRVDLERNKRKLEGD-LKLAQESILDLENDKQQLDER 1080
Query: 349 LTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQ 408
L KK E C LQ+ ++ EQ + Q FQ++ L A + E++
Sbjct: 1081 LKKKDFEY-CQLQSK--------------VEDEQTLGLQ-FQKKIKELQARIEELEEEIE 1124
Query: 409 TVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKEL---LESTIARLRGEL-EASM 464
+ + + + E + ++ ++A T+ Q EL E+ +LR +L EA++
Sbjct: 1125 AERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATL 1184
Query: 465 QEKKSLLEEKERFQREVNKTEKEI---VQERCNLEKELAKNKVDINTLTHNLQTLEEENK 521
Q + + +++ V + ++I + + LEKE ++ K++I+ L+ +++++ +
Sbjct: 1185 QHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 1244
Query: 522 HLADQMASLELQQVTSDYHGL---AQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSF 578
+L +LE Q S+ G Q+ + ++T K++L E G+L +QLEE+
Sbjct: 1245 NLEKICRTLEDQ--LSEARGKNEEIQRSLSELTTQKSRLQTEAGELS---RQLEEKESIV 1299
Query: 579 TDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAH----LKEVKSILERSKEEL 634
+ S + + L+ + + N +A H Q+ H L+E + K EL
Sbjct: 1300 SQLSRSKQAFTQQTEELKRQLEEENKAKNA-LAHALQSSRHDCDLLREQYEEEQEGKAEL 1358
Query: 635 SRTVKCRNAALKESQKLKED--LEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLA 692
R + N+ + + + E ++ E+ E K QR L +++E V ++
Sbjct: 1359 QRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR-LQDSEEQVEAVNAKCASLEK 1417
Query: 693 SHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNS 752
+ ++QG +E + +++ R +S A L K+ Q+ K+ AE W+ + ++ +
Sbjct: 1418 TKQRLQGEVEDLMVDVERANSLAAALDKK----QRNFDKVLAE---WKTKC----EESQA 1466
Query: 753 EIESLQKALGVAREDNRKLAMSLEQAL-------QTNNHLQTKLDHIQEQLESK------ 799
E+E+ K + KL + E+AL + N +L+ ++ + EQ+
Sbjct: 1467 ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHE 1526
Query: 800 -ELERQNLETFK-DRMTEESKVEAELHAERIEALRKQF---QTERETTKKVAQR--EVAE 852
E R+ +E K D + EA L E + LR Q Q + E +K+A++ E+ +
Sbjct: 1527 LEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQ 1586
Query: 853 LKKALDEANFRSVEV--SRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLS-AKANN 909
LK+ R+VE S + E+R + + K+K++ +I++ LS A
Sbjct: 1587 LKRNYQ----RTVETMQSALDAEVRSRNEAIRL-----KKKMEGDLNEIEIQLSHANRQA 1637
Query: 910 AQNIERMKQIEKELKQMELIKDQYQK--KNYEQSLSI--------------QRFVCEMTN 953
A+ ++ ++ ++ +LK +L D + ++ ++ L+I R E T
Sbjct: 1638 AETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE 1697
Query: 954 LQKEM--QMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATE 1011
+++ Q L S + + Q + ++K+ +L E+E+ R + +E +
Sbjct: 1698 RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAK 1757
Query: 1012 NTLKEASVESEQI-------------TANLEEAHRWFKHRFD-GLQLELTKNRLQRPSGE 1057
+ +A++ +E++ NLE+ + +HR D QL L + Q E
Sbjct: 1758 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1817
Query: 1058 DRWQEKDQDVKHDVMSNQSVLHRWERKQNLRPMPKKYHSEVQRK 1101
R +E + +++ + N + + RK R Y SE RK
Sbjct: 1818 TRIRELEFELEGEQKKNTESV-KGLRKYERRVKELTYQSEEDRK 1860
Score = 128 bits (321), Expect = 3e-29
Identities = 214/983 (21%), Positives = 415/983 (42%), Gaps = 164/983 (16%)
Query: 206 KRKMNLKIQELRR--------------QLAQEKYLRESLEKSASAMLLKIQEMGSTVEVE 251
K K LK E + +LA+ + R+ LE+ ++ + ++ V+ E
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAE 895
Query: 252 RKQVHILQQNCIAL--------------RDSIQSAQELLAQEQKKKEELEIATSQLKSDL 297
+ + ++ C L + + +E+ A+ KK +LE S+LK D+
Sbjct: 896 SENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 955
Query: 298 TSRDDLISKLVEEN-------KNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLT 350
+ ++K+ +E KNL + E A L E +L EA ++A D L
Sbjct: 956 DDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQAL---DDLQ 1012
Query: 351 KKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLL---LDAAHASITNEL 407
+ +++ + +T + + + + D ++ L+ E+K+ + + L L A SI +
Sbjct: 1013 AEEDKVNSLNKTKSKLEQQ-VEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD-- 1069
Query: 408 QTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEK-RTAVQKEL--LESTIARLRGELEASM 464
++N+K QL L E+ Q K +D + QK++ L++ I L E+EA
Sbjct: 1070 --LENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAER 1127
Query: 465 QEKKSLLEEKERFQRE-------------VNKTEKEIVQERCNLEKELAKNKVDIN--TL 509
+ +++ + RE V T+ E+ ++R E E K + D+ TL
Sbjct: 1128 ATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKR---EAEFLKLRRDLEEATL 1184
Query: 510 THNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVK 569
H KH AD +A L ++++ + K KL E + ++++
Sbjct: 1185 QHEAMVAALRKKH-ADSVAEL-------------GEQIDNLQRVKQKLEKEKSEFKLEID 1230
Query: 570 QLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILER 629
L ++S S +L K+ + L+ + SE K +Q++ + L KS L+
Sbjct: 1231 DLSSSMES---VSKSKANLEKICRTLEDQL----SEARGKNEEIQRSLSELTTQKSRLQT 1283
Query: 630 SKEELSRTVKCRNAALKESQKLK-------EDLEAVEDRENKKVGNFQRQLAEAKEDNCK 682
ELSR ++ + + + + + K E+L+ + ENK L ++ D
Sbjct: 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDL 1343
Query: 683 VTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQ-QRVQKLEAEVDQWQA 741
+ E +++Q AL K +SE+A + + + + QR ++LE +
Sbjct: 1344 LREQYEEEQEGKAELQRALSKA-------NSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1396
Query: 742 RMLVMEDQ---HNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLES 798
R+ E+Q N++ SL+K + + L + +E+A N L LD Q
Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERA----NSLAAALDKKQRNF-- 1450
Query: 799 KELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALD 858
D++ E K + E +EA K+ + E+ +LK A +
Sbjct: 1451 ------------DKVLAEWKTKCEESQAELEASLKE--------SRSLSTELFKLKNAYE 1490
Query: 859 EANFRSVEVSRTNRELRQKLAEL-EKI---------LESNKEKIKNQKTQIKLHL-SAKA 907
EA + V R N+ L Q++A+L E+I LE ++++I+ +K I+L L A+A
Sbjct: 1491 EALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA 1550
Query: 908 NNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYD 967
++ +I+ EL Q +K + +K E+ I++ N Q+ ++ + +S D
Sbjct: 1551 ALEHEEAKILRIQLELTQ---VKSEIDRKIAEKDEEIEQL---KRNYQRTVETM-QSALD 1603
Query: 968 ASVRNKQQELHLEAE-----RKIRQELENRCQELEETVRHLKKCKEATENT---LKEASV 1019
A VR++ + + L+ + +I +L + ++ ET++HL+ + ++T L +A
Sbjct: 1604 AEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALR 1663
Query: 1020 ESEQITANL---EEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDVKHDVMSNQS 1076
E + L E + + L+ L + R E + ++ V+ N S
Sbjct: 1664 GQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTS 1723
Query: 1077 VLHRWERKQNLRPMPKKYHSEVQ 1099
++H K+ L + SEV+
Sbjct: 1724 LIH---TKKKLETDLMQLQSEVE 1743
Score = 114 bits (285), Expect = 5e-25
Identities = 159/798 (19%), Positives = 337/798 (42%), Gaps = 99/798 (12%)
Query: 107 LESLMQSLKMNIFRLQTEKDLNPQKTA-FLKDRLN-------------AIQEEHSKDLKL 152
LE L + L+ T+ +LN ++ A FLK R + A++++H+ +
Sbjct: 1144 LEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAE 1203
Query: 153 LHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAII-------------- 198
L ++ NL++ + +++E+ + + E+ L+++++ S++K N I
Sbjct: 1204 LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGK 1263
Query: 199 -EE------ELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVE 251
EE EL T K ++ + EL RQL +++ + L +S A + +E+ +E E
Sbjct: 1264 NEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEE 1323
Query: 252 RKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDL--------TSRDDL 303
K + L + R +E +EQ+ K EL+ A S+ S++ T
Sbjct: 1324 NKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR 1383
Query: 304 ISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQL---TKKCSELSCML 360
+L E K L E+ + ++ SL + ++ Q + L ++ + L+ L
Sbjct: 1384 TEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAAL 1443
Query: 361 QTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLL------LDAAHASITNELQTVQNEK 414
+++A+ + + Q + + +E L L A+ ++L+TV+ E
Sbjct: 1444 DKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN 1503
Query: 415 TQLQ---AHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLL 471
L+ A L I E+ + I + + + K+ ++K +++ +++E ++ L
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEK-----------ADIQLALEEAEAAL 1552
Query: 472 EEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLE 531
E +E ++ + + E+ Q + +++++A+ +I L N Q E + D
Sbjct: 1553 EHEE---AKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSR 1609
Query: 532 LQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKM 591
+ + L ++ + E + +L++ N + +K L DT L D +
Sbjct: 1610 NEAIR-----LKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRG 1664
Query: 592 NKYLQTKYA----QAN---SELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAA 644
+ L+ + A +AN +E+ R L+Q + K + L S E + +
Sbjct: 1665 QEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSL 1724
Query: 645 LKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLE------NVLASHSKMQ 698
+ +KL+ DL ++ + + +AK+ +M E + A +M+
Sbjct: 1725 IHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1784
Query: 699 GALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQ 758
LE+ +L R E L + ++++QKLE + + + + + ++ ++ L+
Sbjct: 1785 KNLEQTVKDLQHRLDEAEQLALKG--GKKQIQKLETRIRELEFELEGEQKKNTESVKGLR 1842
Query: 759 ------KALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDR 812
K L E++RK + L+ + + LQ K+ + Q E + E+ N K R
Sbjct: 1843 KYERRVKELTYQSEEDRKNVLRLQDLV---DKLQVKVKSYKRQAEEAD-EQANAHLTKFR 1898
Query: 813 MTEESKVEAELHAERIEA 830
+ EAE A+ E+
Sbjct: 1899 KAQHELEEAEERADIAES 1916
Score = 73.9 bits (180), Expect = 8e-13
Identities = 122/590 (20%), Positives = 256/590 (43%), Gaps = 49/590 (8%)
Query: 84 AICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQ---KTAFLKDRLN 140
A+ +++ ++ + + R E L ++ K RLQ ++ K A L+
Sbjct: 1361 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQ 1420
Query: 141 AIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEE 200
+Q E +DL ++ +E N L A +++ + D+V T SQ + A++ E
Sbjct: 1421 RLQGE-VEDL-MVDVERAN---SLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKES 1475
Query: 201 E-LKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTV---EVERKQVH 256
L T K+ +E QL K ++LE+ + + +I E G T+ E RKQ+
Sbjct: 1476 RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIE 1535
Query: 257 ILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQI 316
+ + + ++ +++ A+ L E+ K +++ +Q+KS++ D I++ EE + L+
Sbjct: 1536 LEKAD---IQLALEEAEAALEHEEAKILRIQLELTQVKSEI---DRKIAEKDEEIEQLKR 1589
Query: 317 SFNKEHEE-NAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQ 375
++ + E + L +E+ S +EA + + L +E+ L + A + H
Sbjct: 1590 NYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDL----NEIEIQLSHANRQAAETLK-HL 1644
Query: 376 AILQVEQKMMTQTFQEQNLLLDAA---HASITNELQTVQNEKTQLQAHLDHL--ILEHNQ 430
+Q + K + L LD A + +L V+ LQA ++ L LE +
Sbjct: 1645 RSVQGQLK-------DTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE 1697
Query: 431 CIQKAQDAEKRTAVQKELL----ESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEK 486
+K + E + ++ L +++ + +LE + + +S +E+ R R + K
Sbjct: 1698 RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAK 1757
Query: 487 EIVQERCNLEKELAKNK---VDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLA 543
+ + + + +EL K + + + NL+ ++ +H D+ L L+
Sbjct: 1758 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI---- 1813
Query: 544 QQKVE-KITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQA 602
QK+E +I E + +L E K VK L + + + + Q++ RK LQ +
Sbjct: 1814 -QKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKL 1872
Query: 603 NSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLK 652
++ + + ++AD + +++ EL + + A + KL+
Sbjct: 1873 QVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLR 1922
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 157 bits (397), Expect = 5e-38
Identities = 215/1043 (20%), Positives = 438/1043 (41%), Gaps = 133/1043 (12%)
Query: 100 LVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEH---SKDLKLLHLE 156
+ +M LE ++ + +LQ EK K L+D + + +++ SK+ KLL
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 157 VMNLRQQLRAVKEE-------EDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKM 209
+ +L L +E+ ++K + + L LK ++++ ++ +L+
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 210 NLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSI 269
+ +I +L+ Q+A+ K E+ A L ++ + + K++ L+ + L++ +
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 270 QSAQELLAQEQKKK----EELEIATSQLKSDLTS---RDDLISKLVEENKNLQISFNKEH 322
S + + +K+K EELE ++L+ L S + +L +K +E L+ + ++E
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 323 EENAYLRSEIMSLH-EASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVE 381
+ E+ H +A E+ +Q + + L QT+ E A + + + + Q +
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 382 Q-------KMMTQTFQEQNLLLDA--AHASITNELQTVQNEKTQLQAHLDHLILEHNQCI 432
Q K+ Q + Q+ D A A + +++ +QNE + L+ + I
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA---EGKAI 1311
Query: 433 QKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQER 492
+ A+D L + +Q+ + LL+E+ R + V+ +++ +ER
Sbjct: 1312 KLAKDV-------------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 493 CNLEKEL-----AKNKVDINTLTHNLQTLEEENKHLADQMASLEL-----QQVTSDYHGL 542
+L+ +L AK ++ + T N+Q L + K L D +++E ++ + L
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQ-LSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 543 AQQKVEK------ITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQ 596
QQ EK + ++KN+L E L + + + V + + D L K +
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 597 TKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLE 656
+KYA A+ + L +KEEL RT K A +++ K+D+
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 657 AVEDRENKKVGNFQRQLAEAK------EDNCKVTIMLENVLASHSKMQGALEKVQIELGR 710
K + Q+ E K ED + T + L MQ + + +L
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE--DAKLRLEVNMQALKGQFERDLQA 1589
Query: 711 RDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE---- 766
RD + N+++ ++L+ ++ +++ + E E Q+AL A +
Sbjct: 1590 RDEQ----------NEEKRRQLQRQLHEYETEL---------EDERKQRALAAAAKKKLE 1630
Query: 767 -DNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHA 825
D + L + + A++ +L +Q Q++ + E ++ +D + +K E E A
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK-ENEKKA 1689
Query: 826 ERIEALRKQFQTE---RETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELE 882
+ +EA Q Q + E +K A E EL + L + + R L ++A+LE
Sbjct: 1690 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE 1749
Query: 883 KILESNK----------EKIKNQKTQIKLHLSAKANNAQNIE--------RMKQIEKELK 924
+ LE + K Q Q+ L+ + + AQ E + K++ +L
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Query: 925 QME-LIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAER 983
+ME +K +++ I + ++ +E Q KS + K+ L +E ER
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFD--- 1040
K+ ++ + + ++ V+ LK+ L+EA ES++I AN + R +
Sbjct: 1870 KMAEQYKEQAEKGNARVKQLKR-------QLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 1041 --GLQLELTKNRLQRPSGEDRWQ 1061
G ++ K++L+ P ++ Q
Sbjct: 1923 AMGREVNALKSKLRGPPPQETSQ 1945
Score = 151 bits (382), Expect = 3e-36
Identities = 206/1016 (20%), Positives = 440/1016 (43%), Gaps = 138/1016 (13%)
Query: 163 QLRAVKEEEDKAQDEVQRLTATLKIA-----------SQTKKNAAIIEEELKTTKRKMNL 211
Q+ +EE +DE+Q+ + A SQ + +++E+L+ + ++
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ-AETELYA 911
Query: 212 KIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQS 271
+ +E+R +LA +K E + A L + ++ G ++ ERK++
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM---------------- 955
Query: 272 AQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSE 331
AQ++L E++ +EE E A +L+ + + + I KL +E + NK +E L
Sbjct: 956 AQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 332 I----MSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMM-- 385
I +L E EKA+ LTK ++ M+ + + + Q + ++++K+
Sbjct: 1015 ISDLTTNLAEEEEKAK----NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 386 TQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTA-V 444
F EQ L A A + +L + E A LD I + N ++K ++ E + +
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130
Query: 445 QKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKT-EKEIVQERCNLEKE----L 499
Q++L AR + E ++K+ L EE E + E+ T + Q+ ++E +
Sbjct: 1131 QEDLDSERAARNKAE-----KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 500 AKNKVDINTLTHNLQTLEEENKH------LADQMASLELQQVTSDYHGLAQQK------- 546
K +D T +H Q E KH L +Q+ + + D + +K
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 547 -VEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQ-NDHLRKMNKYLQTKYAQANS 604
+ + ++K ++ ++ KL+ +V++L+ + + ND + K+ +++ N
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN- 1304
Query: 605 ELSAKRVHLQQ----ADAHLKEVKSIL-ERSKEELSRTVKCRNAALKES---QKLKEDLE 656
E K + L + + L++ + +L E ++++L+ + K R + + +L E++E
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1364
Query: 657 AVEDRE-------------NKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEK 703
A ++ E KK+ +F + +E + +EN+ + + A +K
Sbjct: 1365 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 704 VQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGV 763
++ R E+ L + D +Q V LE + ++ + ++ + + +A
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484
Query: 764 AREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRM------TEES 817
ARE K A+SL +AL+ + +L+ + L++ E ++L + KD + E+S
Sbjct: 1485 AREKETK-ALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKDDVGKNVHELEKS 1540
Query: 818 KVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQK 877
K E E ++ ++ + E + T+ R E+ + F ++ + + +K
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLR--LEVNMQALKGQFER-DLQARDEQNEEK 1597
Query: 878 LAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKN 937
+L++ L + ++++++ Q L +AK K++E +LK +EL D K
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAK----------KKLEGDLKDLELQADSAIKGR 1647
Query: 938 YEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELE 997
E +++ +M + Q+E++ R + E+ A +E E + + LE
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELE---------DARASRDEIFATA-----KENEKKAKSLE 1693
Query: 998 ETVRHLKKCKEATENTLKEASVESEQITAN----------LEEAHRWFKHRFDGLQLELT 1047
+ L++ A E K+A +E E++ L++ R + R L+ EL
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 1048 KNRLQRPSGEDRWQEKDQDVKHDVMSNQSVLHR--WERKQNLRPMPKKYHSEVQRK 1101
+ + + DR ++ Q + +SN+ R ++ ++ R ++ + E++ K
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQ--LSNELATERSTAQKNESARQQLERQNKELRSK 1807
Score = 133 bits (335), Expect = 8e-31
Identities = 189/923 (20%), Positives = 410/923 (44%), Gaps = 107/923 (11%)
Query: 257 ILQQNCIA---LRD----SIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVE 309
++Q+NC A LR+ + + + L Q +++EE++ +L+ + ++L E
Sbjct: 825 VIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKE 884
Query: 310 -ENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKA 368
E K+ Q++ EE L+ ++ + E +A+ + +L K EL +L + +A
Sbjct: 885 LEQKHSQLT-----EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM---EA 936
Query: 369 RIIA--DHQAILQVEQKMMTQTF---QEQNLLLDAAHASITNELQTVQNEKTQLQAHLDH 423
R+ D LQ E+K M Q +EQ +AA + E T + + +L+ +
Sbjct: 937 RLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV 996
Query: 424 LILEHNQCIQKAQDAEKRTA------VQKELLESTIARLRGELEASMQEKKSLLEEKERF 477
+ ++N+ ++ + E+R + ++E + +L+ + E+ + E + L+++E+
Sbjct: 997 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 478 QREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENK----HLADQMASL--- 530
++E+ K ++++ + + +++A + I L L EEE + L D++A
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 531 -----ELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN 585
EL+ SD Q+ ++ ++NK + L +++ L+ +++ D++
Sbjct: 1117 LKKIRELEGHISDL----QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 586 DHLRKMNKY----------------------LQTKYAQANSELSAKRVHLQQADAHLKEV 623
LR + ++ K+AQA EL+ + ++A A+L +
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 624 KSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKV 683
K LE+ +L+ ++ A +E + K+ LEA K + +R AE + K+
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 684 TIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARM 743
+E+V ++ +G K+ ++ S++ ++ ++ + ++ Q +
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 744 LVMEDQHNSEIESLQ------KALGVAREDNRK----LAMSLEQALQTNNHLQTKLDHIQ 793
++DQ + E+E+ Q L + D++K A ++E + Q +++++
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 794 EQLESKELERQNLETFKDRMTEE-SKVEAELHAER-----IEALRKQFQTERETTKKVAQ 847
+Q E K LE K+R+ +E + +L +R +E +++F K ++
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 848 REVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKA 907
+ E +A EA + + R L + L E++ +N K K +++ +S+K
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKD 1528
Query: 908 NNAQNIERMKQIEKELK-QMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLA-KSQ 965
+ +N+ +++ ++ L+ QME +K Q ++ E + E L+ E+ M A K Q
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT------EDAKLRLEVNMQALKGQ 1582
Query: 966 Y--DASVRNKQQELHLEAERKIRQELENRCQELEETVRH---LKKCKEATENTLKEASVE 1020
+ D R++Q E E R+++++L ELE+ + K+ E LK+ ++
Sbjct: 1583 FERDLQARDEQNE---EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1639
Query: 1021 SEQITANLEEA---HRWFKHRFDGLQLELTKNRLQRP---SGEDRWQEKDQDVKHDVMSN 1074
++ EEA R + + Q EL R R + ++K + ++ D+M
Sbjct: 1640 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 1075 QSVLHRWERKQNLRPMPKKYHSE 1097
Q L ER + + K+ +E
Sbjct: 1700 QEDLAAAERARKQADLEKEELAE 1722
Score = 78.6 bits (192), Expect = 3e-14
Identities = 100/458 (21%), Positives = 195/458 (42%), Gaps = 31/458 (6%)
Query: 59 RGYLEAPDCLEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNI 118
R EA + E+L+ + + E + + K D+ KN L LE+ M+ +K +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-GKNVHELEKSKRALETQMEEMKTQL 1555
Query: 119 FRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQL-RAVKEEEDKAQDE 177
L+ E L+ + A++ + +DL+ + R+QL R + E E + +DE
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Query: 178 VQRLTATLKIASQTKKNAAIIEEELKTTK--RKMNLKIQELRRQLAQEKYLRESLEKSAS 235
R L A++ K + + EL+ + I++LR+ AQ K + LE + +
Sbjct: 1616 --RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673
Query: 236 AMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKS 295
+ E+ +T + K+ L+ + + L++ + +A+ Q +KEEL +L S
Sbjct: 1674 SR----DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL---AEELAS 1726
Query: 296 DLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSE 355
L+ R + L +E + L+ + EE L E ++ S++ + Q + +E
Sbjct: 1727 SLSGR----NALQDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 356 LSCMLQTVTM-EKARIIADHQ-----AILQVEQKMMTQTFQEQNLLLDAAHASITNELQT 409
L+ T E AR + Q + L + + F+ L+A A + +++
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 410 VQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIAR---LRGELEASMQE 466
EK L + + + + +D K KE E AR L+ +LE + +E
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Query: 467 KKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKV 504
+ + + + QRE+++ + E E K+K+
Sbjct: 1900 SQRINANRRKLQRELDEATES--NEAMGREVNALKSKL 1935
Score = 43.1 bits (100), Expect = 0.001
Identities = 59/319 (18%), Positives = 123/319 (38%), Gaps = 61/319 (19%)
Query: 17 SPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKV 76
S I ATA E +++ + +E L++DL + K+ LE + E+L S
Sbjct: 1674 SRDEIFATAKEN----EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS-- 1727
Query: 77 ISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLK 136
+G+ L+ + L+ I +L+ E + +
Sbjct: 1728 ---------LSGRN---------------ALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 137 DRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAA 196
DR+ ++ ++ N R+ ++ + A+ +++R L+ S+ +
Sbjct: 1764 DRVRKATQQAE--------QLSNELATERSTAQKNESARQQLERQNKELR--SKLHEMEG 1813
Query: 197 IIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVH 256
++ + K+T + KI +L Q+ QE +++ KS K++E+ VE ERK
Sbjct: 1814 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK--- 1870
Query: 257 ILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQI 316
+ Q +++ E+ QLK L ++ ++ + LQ
Sbjct: 1871 ------------------MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 1912
Query: 317 SFNKEHEENAYLRSEIMSL 335
++ E N + E+ +L
Sbjct: 1913 ELDEATESNEAMGREVNAL 1931
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 157 bits (397), Expect = 5e-38
Identities = 215/1043 (20%), Positives = 438/1043 (41%), Gaps = 133/1043 (12%)
Query: 100 LVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEH---SKDLKLLHLE 156
+ +M LE ++ + +LQ EK K L+D + + +++ SK+ KLL
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 157 VMNLRQQLRAVKEE-------EDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKM 209
+ +L L +E+ ++K + + L LK ++++ ++ +L+
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 210 NLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSI 269
+ +I +L+ Q+A+ K E+ A L ++ + + K++ L+ + L++ +
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 270 QSAQELLAQEQKKK----EELEIATSQLKSDLTS---RDDLISKLVEENKNLQISFNKEH 322
S + + +K+K EELE ++L+ L S + +L +K +E L+ + ++E
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 323 EENAYLRSEIMSLH-EASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVE 381
+ E+ H +A E+ +Q + + L QT+ E A + + + + Q +
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 382 Q-------KMMTQTFQEQNLLLDA--AHASITNELQTVQNEKTQLQAHLDHLILEHNQCI 432
Q K+ Q + Q+ D A A + +++ +QNE + L+ + I
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA---EGKAI 1304
Query: 433 QKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQER 492
+ A+D L + +Q+ + LL+E+ R + V+ +++ +ER
Sbjct: 1305 KLAKDV-------------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 493 CNLEKEL-----AKNKVDINTLTHNLQTLEEENKHLADQMASLEL-----QQVTSDYHGL 542
+L+ +L AK ++ + T N+Q L + K L D +++E ++ + L
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQ-LSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 543 AQQKVEK------ITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQ 596
QQ EK + ++KN+L E L + + + V + + D L K +
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 597 TKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLE 656
+KYA A+ + L +KEEL RT K A +++ K+D+
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 657 AVEDRENKKVGNFQRQLAEAK------EDNCKVTIMLENVLASHSKMQGALEKVQIELGR 710
K + Q+ E K ED + T + L MQ + + +L
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE--DAKLRLEVNMQALKGQFERDLQA 1582
Query: 711 RDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE---- 766
RD + N+++ ++L+ ++ +++ + E E Q+AL A +
Sbjct: 1583 RDEQ----------NEEKRRQLQRQLHEYETEL---------EDERKQRALAAAAKKKLE 1623
Query: 767 -DNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHA 825
D + L + + A++ +L +Q Q++ + E ++ +D + +K E E A
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK-ENEKKA 1682
Query: 826 ERIEALRKQFQTE---RETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELE 882
+ +EA Q Q + E +K A E EL + L + + R L ++A+LE
Sbjct: 1683 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE 1742
Query: 883 KILESNK----------EKIKNQKTQIKLHLSAKANNAQNIE--------RMKQIEKELK 924
+ LE + K Q Q+ L+ + + AQ E + K++ +L
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Query: 925 QME-LIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAER 983
+ME +K +++ I + ++ +E Q KS + K+ L +E ER
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFD--- 1040
K+ ++ + + ++ V+ LK+ L+EA ES++I AN + R +
Sbjct: 1863 KMAEQYKEQAEKGNARVKQLKR-------QLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 1041 --GLQLELTKNRLQRPSGEDRWQ 1061
G ++ K++L+ P ++ Q
Sbjct: 1916 AMGREVNALKSKLRGPPPQETSQ 1938
Score = 151 bits (382), Expect = 3e-36
Identities = 206/1016 (20%), Positives = 440/1016 (43%), Gaps = 138/1016 (13%)
Query: 163 QLRAVKEEEDKAQDEVQRLTATLKIA-----------SQTKKNAAIIEEELKTTKRKMNL 211
Q+ +EE +DE+Q+ + A SQ + +++E+L+ + ++
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ-AETELYA 904
Query: 212 KIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQS 271
+ +E+R +LA +K E + A L + ++ G ++ ERK++
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM---------------- 948
Query: 272 AQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSE 331
AQ++L E++ +EE E A +L+ + + + I KL +E + NK +E L
Sbjct: 949 AQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 332 I----MSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMM-- 385
I +L E EKA+ LTK ++ M+ + + + Q + ++++K+
Sbjct: 1008 ISDLTTNLAEEEEKAK----NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 386 TQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTA-V 444
F EQ L A A + +L + E A LD I + N ++K ++ E + +
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123
Query: 445 QKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKT-EKEIVQERCNLEKE----L 499
Q++L AR + E ++K+ L EE E + E+ T + Q+ ++E +
Sbjct: 1124 QEDLDSERAARNKAE-----KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 500 AKNKVDINTLTHNLQTLEEENKH------LADQMASLELQQVTSDYHGLAQQK------- 546
K +D T +H Q E KH L +Q+ + + D + +K
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 547 -VEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQ-NDHLRKMNKYLQTKYAQANS 604
+ + ++K ++ ++ KL+ +V++L+ + + ND + K+ +++ N
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN- 1297
Query: 605 ELSAKRVHLQQ----ADAHLKEVKSIL-ERSKEELSRTVKCRNAALKES---QKLKEDLE 656
E K + L + + L++ + +L E ++++L+ + K R + + +L E++E
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1357
Query: 657 AVEDRE-------------NKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEK 703
A ++ E KK+ +F + +E + +EN+ + + A +K
Sbjct: 1358 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Query: 704 VQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGV 763
++ R E+ L + D +Q V LE + ++ + ++ + + +A
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477
Query: 764 AREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRM------TEES 817
ARE K A+SL +AL+ + +L+ + L++ E ++L + KD + E+S
Sbjct: 1478 AREKETK-ALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKDDVGKNVHELEKS 1533
Query: 818 KVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQK 877
K E E ++ ++ + E + T+ R E+ + F ++ + + +K
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLR--LEVNMQALKGQFER-DLQARDEQNEEK 1590
Query: 878 LAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKN 937
+L++ L + ++++++ Q L +AK K++E +LK +EL D K
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAK----------KKLEGDLKDLELQADSAIKGR 1640
Query: 938 YEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELE 997
E +++ +M + Q+E++ R + E+ A +E E + + LE
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELE---------DARASRDEIFATA-----KENEKKAKSLE 1686
Query: 998 ETVRHLKKCKEATENTLKEASVESEQITAN----------LEEAHRWFKHRFDGLQLELT 1047
+ L++ A E K+A +E E++ L++ R + R L+ EL
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 1048 KNRLQRPSGEDRWQEKDQDVKHDVMSNQSVLHR--WERKQNLRPMPKKYHSEVQRK 1101
+ + + DR ++ Q + +SN+ R ++ ++ R ++ + E++ K
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQ--LSNELATERSTAQKNESARQQLERQNKELRSK 1800
Score = 133 bits (335), Expect = 8e-31
Identities = 189/923 (20%), Positives = 410/923 (44%), Gaps = 107/923 (11%)
Query: 257 ILQQNCIA---LRD----SIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVE 309
++Q+NC A LR+ + + + L Q +++EE++ +L+ + ++L E
Sbjct: 818 VIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKE 877
Query: 310 -ENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKA 368
E K+ Q++ EE L+ ++ + E +A+ + +L K EL +L + +A
Sbjct: 878 LEQKHSQLT-----EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM---EA 929
Query: 369 RIIA--DHQAILQVEQKMMTQTF---QEQNLLLDAAHASITNELQTVQNEKTQLQAHLDH 423
R+ D LQ E+K M Q +EQ +AA + E T + + +L+ +
Sbjct: 930 RLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV 989
Query: 424 LILEHNQCIQKAQDAEKRTA------VQKELLESTIARLRGELEASMQEKKSLLEEKERF 477
+ ++N+ ++ + E+R + ++E + +L+ + E+ + E + L+++E+
Sbjct: 990 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 478 QREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENK----HLADQMASL--- 530
++E+ K ++++ + + +++A + I L L EEE + L D++A
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 531 -----ELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN 585
EL+ SD Q+ ++ ++NK + L +++ L+ +++ D++
Sbjct: 1110 LKKIRELEGHISDL----QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 586 DHLRKMNKY----------------------LQTKYAQANSELSAKRVHLQQADAHLKEV 623
LR + ++ K+AQA EL+ + ++A A+L +
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 624 KSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKV 683
K LE+ +L+ ++ A +E + K+ LEA K + +R AE + K+
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 684 TIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARM 743
+E+V ++ +G K+ ++ S++ ++ ++ + ++ Q +
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 744 LVMEDQHNSEIESLQ------KALGVAREDNRK----LAMSLEQALQTNNHLQTKLDHIQ 793
++DQ + E+E+ Q L + D++K A ++E + Q +++++
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 794 EQLESKELERQNLETFKDRMTEE-SKVEAELHAER-----IEALRKQFQTERETTKKVAQ 847
+Q E K LE K+R+ +E + +L +R +E +++F K ++
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 848 REVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKA 907
+ E +A EA + + R L + L E++ +N K K +++ +S+K
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKD 1521
Query: 908 NNAQNIERMKQIEKELK-QMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLA-KSQ 965
+ +N+ +++ ++ L+ QME +K Q ++ E + E L+ E+ M A K Q
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT------EDAKLRLEVNMQALKGQ 1575
Query: 966 Y--DASVRNKQQELHLEAERKIRQELENRCQELEETVRH---LKKCKEATENTLKEASVE 1020
+ D R++Q E E R+++++L ELE+ + K+ E LK+ ++
Sbjct: 1576 FERDLQARDEQNE---EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1632
Query: 1021 SEQITANLEEA---HRWFKHRFDGLQLELTKNRLQRP---SGEDRWQEKDQDVKHDVMSN 1074
++ EEA R + + Q EL R R + ++K + ++ D+M
Sbjct: 1633 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 1075 QSVLHRWERKQNLRPMPKKYHSE 1097
Q L ER + + K+ +E
Sbjct: 1693 QEDLAAAERARKQADLEKEELAE 1715
Score = 78.6 bits (192), Expect = 3e-14
Identities = 100/458 (21%), Positives = 195/458 (42%), Gaps = 31/458 (6%)
Query: 59 RGYLEAPDCLEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNI 118
R EA + E+L+ + + E + + K D+ KN L LE+ M+ +K +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-GKNVHELEKSKRALETQMEEMKTQL 1548
Query: 119 FRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQL-RAVKEEEDKAQDE 177
L+ E L+ + A++ + +DL+ + R+QL R + E E + +DE
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Query: 178 VQRLTATLKIASQTKKNAAIIEEELKTTK--RKMNLKIQELRRQLAQEKYLRESLEKSAS 235
R L A++ K + + EL+ + I++LR+ AQ K + LE + +
Sbjct: 1609 --RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 236 AMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKS 295
+ E+ +T + K+ L+ + + L++ + +A+ Q +KEEL +L S
Sbjct: 1667 SR----DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL---AEELAS 1719
Query: 296 DLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSE 355
L+ R + L +E + L+ + EE L E ++ S++ + Q + +E
Sbjct: 1720 SLSGR----NALQDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 356 LSCMLQTVTM-EKARIIADHQ-----AILQVEQKMMTQTFQEQNLLLDAAHASITNELQT 409
L+ T E AR + Q + L + + F+ L+A A + +++
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 410 VQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIAR---LRGELEASMQE 466
EK L + + + + +D K KE E AR L+ +LE + +E
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Query: 467 KKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKV 504
+ + + + QRE+++ + E E K+K+
Sbjct: 1893 SQRINANRRKLQRELDEATES--NEAMGREVNALKSKL 1928
Score = 43.1 bits (100), Expect = 0.001
Identities = 59/319 (18%), Positives = 123/319 (38%), Gaps = 61/319 (19%)
Query: 17 SPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKV 76
S I ATA E +++ + +E L++DL + K+ LE + E+L S
Sbjct: 1667 SRDEIFATAKEN----EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS-- 1720
Query: 77 ISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLK 136
+G+ L+ + L+ I +L+ E + +
Sbjct: 1721 ---------LSGRN---------------ALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 137 DRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAA 196
DR+ ++ ++ N R+ ++ + A+ +++R L+ S+ +
Sbjct: 1757 DRVRKATQQAE--------QLSNELATERSTAQKNESARQQLERQNKELR--SKLHEMEG 1806
Query: 197 IIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVH 256
++ + K+T + KI +L Q+ QE +++ KS K++E+ VE ERK
Sbjct: 1807 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK--- 1863
Query: 257 ILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQI 316
+ Q +++ E+ QLK L ++ ++ + LQ
Sbjct: 1864 ------------------MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 1905
Query: 317 SFNKEHEENAYLRSEIMSL 335
++ E N + E+ +L
Sbjct: 1906 ELDEATESNEAMGREVNAL 1924
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 156 bits (395), Expect = 9e-38
Identities = 214/1035 (20%), Positives = 435/1035 (42%), Gaps = 133/1035 (12%)
Query: 100 LVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEH---SKDLKLLHLE 156
+ +M LE ++ + +LQ EK K L+D + + +++ SK+ KLL
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 157 VMNLRQQLRAVKEE-------EDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKM 209
+ +L L +E+ ++K + + L LK ++++ ++ +L+
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 210 NLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSI 269
+ +I +L+ Q+A+ K E+ A L ++ + + K++ L+ + L++ +
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 270 QSAQELLAQEQKKK----EELEIATSQLKSDLTS---RDDLISKLVEENKNLQISFNKEH 322
S + + +K+K EELE ++L+ L S + +L +K +E L+ + ++E
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 323 EENAYLRSEIMSLH-EASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVE 381
+ E+ H +A E+ +Q + + L QT+ E A + + + + Q +
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 382 Q-------KMMTQTFQEQNLLLDA--AHASITNELQTVQNEKTQLQAHLDHLILEHNQCI 432
Q K+ Q + Q+ D A A + +++ +QNE + L+ + I
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA---EGKAI 1304
Query: 433 QKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQER 492
+ A+D L + +Q+ + LL+E+ R + V+ +++ +ER
Sbjct: 1305 KLAKDV-------------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 493 CNLEKEL-----AKNKVDINTLTHNLQTLEEENKHLADQMASLEL-----QQVTSDYHGL 542
+L+ +L AK ++ + T N+Q L + K L D +++E ++ + L
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQ-LSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 543 AQQKVEK------ITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQ 596
QQ EK + ++KN+L E L + + + V + + D L K +
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 597 TKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLE 656
+KYA A+ + L +KEEL RT K A +++ K+D+
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 657 AVEDRENKKVGNFQRQLAEAK------EDNCKVTIMLENVLASHSKMQGALEKVQIELGR 710
K + Q+ E K ED + T + L MQ + + +L
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE--DAKLRLEVNMQALKGQFERDLQA 1582
Query: 711 RDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE---- 766
RD + N+++ ++L+ ++ +++ + E E Q+AL A +
Sbjct: 1583 RDEQ----------NEEKRRQLQRQLHEYETEL---------EDERKQRALAAAAKKKLE 1623
Query: 767 -DNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHA 825
D + L + + A++ +L +Q Q++ + E ++ +D + +K E E A
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK-ENEKKA 1682
Query: 826 ERIEALRKQFQTE---RETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELE 882
+ +EA Q Q + E +K A E EL + L + + R L ++A+LE
Sbjct: 1683 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE 1742
Query: 883 KILESNK----------EKIKNQKTQIKLHLSAKANNAQNIE--------RMKQIEKELK 924
+ LE + K Q Q+ L+ + + AQ E + K++ +L
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Query: 925 QME-LIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAER 983
+ME +K +++ I + ++ +E Q KS + K+ L +E ER
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFD--- 1040
K+ ++ + + ++ V+ LK+ L+EA ES++I AN + R +
Sbjct: 1863 KMAEQYKEQAEKGNARVKQLKR-------QLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 1041 --GLQLELTKNRLQR 1053
G ++ K++L+R
Sbjct: 1916 AMGREVNALKSKLRR 1930
Score = 151 bits (382), Expect = 3e-36
Identities = 206/1016 (20%), Positives = 440/1016 (43%), Gaps = 138/1016 (13%)
Query: 163 QLRAVKEEEDKAQDEVQRLTATLKIA-----------SQTKKNAAIIEEELKTTKRKMNL 211
Q+ +EE +DE+Q+ + A SQ + +++E+L+ + ++
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ-AETELYA 904
Query: 212 KIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQS 271
+ +E+R +LA +K E + A L + ++ G ++ ERK++
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM---------------- 948
Query: 272 AQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSE 331
AQ++L E++ +EE E A +L+ + + + I KL +E + NK +E L
Sbjct: 949 AQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 332 I----MSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMM-- 385
I +L E EKA+ LTK ++ M+ + + + Q + ++++K+
Sbjct: 1008 ISDLTTNLAEEEEKAK----NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 386 TQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTA-V 444
F EQ L A A + +L + E A LD I + N ++K ++ E + +
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123
Query: 445 QKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKT-EKEIVQERCNLEKE----L 499
Q++L AR + E ++K+ L EE E + E+ T + Q+ ++E +
Sbjct: 1124 QEDLDSERAARNKAE-----KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 500 AKNKVDINTLTHNLQTLEEENKH------LADQMASLELQQVTSDYHGLAQQK------- 546
K +D T +H Q E KH L +Q+ + + D + +K
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 547 -VEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQ-NDHLRKMNKYLQTKYAQANS 604
+ + ++K ++ ++ KL+ +V++L+ + + ND + K+ +++ N
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN- 1297
Query: 605 ELSAKRVHLQQ----ADAHLKEVKSIL-ERSKEELSRTVKCRNAALKES---QKLKEDLE 656
E K + L + + L++ + +L E ++++L+ + K R + + +L E++E
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1357
Query: 657 AVEDRE-------------NKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEK 703
A ++ E KK+ +F + +E + +EN+ + + A +K
Sbjct: 1358 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Query: 704 VQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGV 763
++ R E+ L + D +Q V LE + ++ + ++ + + +A
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477
Query: 764 AREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRM------TEES 817
ARE K A+SL +AL+ + +L+ + L++ E ++L + KD + E+S
Sbjct: 1478 AREKETK-ALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKDDVGKNVHELEKS 1533
Query: 818 KVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQK 877
K E E ++ ++ + E + T+ R E+ + F ++ + + +K
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLR--LEVNMQALKGQFER-DLQARDEQNEEK 1590
Query: 878 LAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKN 937
+L++ L + ++++++ Q L +AK K++E +LK +EL D K
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAK----------KKLEGDLKDLELQADSAIKGR 1640
Query: 938 YEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELE 997
E +++ +M + Q+E++ R + E+ A +E E + + LE
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELE---------DARASRDEIFATA-----KENEKKAKSLE 1686
Query: 998 ETVRHLKKCKEATENTLKEASVESEQITAN----------LEEAHRWFKHRFDGLQLELT 1047
+ L++ A E K+A +E E++ L++ R + R L+ EL
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 1048 KNRLQRPSGEDRWQEKDQDVKHDVMSNQSVLHR--WERKQNLRPMPKKYHSEVQRK 1101
+ + + DR ++ Q + +SN+ R ++ ++ R ++ + E++ K
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQ--LSNELATERSTAQKNESARQQLERQNKELRSK 1800
Score = 133 bits (335), Expect = 8e-31
Identities = 189/923 (20%), Positives = 410/923 (44%), Gaps = 107/923 (11%)
Query: 257 ILQQNCIA---LRD----SIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVE 309
++Q+NC A LR+ + + + L Q +++EE++ +L+ + ++L E
Sbjct: 818 VIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKE 877
Query: 310 -ENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKA 368
E K+ Q++ EE L+ ++ + E +A+ + +L K EL +L + +A
Sbjct: 878 LEQKHSQLT-----EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM---EA 929
Query: 369 RIIA--DHQAILQVEQKMMTQTF---QEQNLLLDAAHASITNELQTVQNEKTQLQAHLDH 423
R+ D LQ E+K M Q +EQ +AA + E T + + +L+ +
Sbjct: 930 RLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV 989
Query: 424 LILEHNQCIQKAQDAEKRTA------VQKELLESTIARLRGELEASMQEKKSLLEEKERF 477
+ ++N+ ++ + E+R + ++E + +L+ + E+ + E + L+++E+
Sbjct: 990 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 478 QREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENK----HLADQMASL--- 530
++E+ K ++++ + + +++A + I L L EEE + L D++A
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 531 -----ELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN 585
EL+ SD Q+ ++ ++NK + L +++ L+ +++ D++
Sbjct: 1110 LKKIRELEGHISDL----QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 586 DHLRKMNKY----------------------LQTKYAQANSELSAKRVHLQQADAHLKEV 623
LR + ++ K+AQA EL+ + ++A A+L +
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 624 KSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKV 683
K LE+ +L+ ++ A +E + K+ LEA K + +R AE + K+
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 684 TIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARM 743
+E+V ++ +G K+ ++ S++ ++ ++ + ++ Q +
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 744 LVMEDQHNSEIESLQ------KALGVAREDNRK----LAMSLEQALQTNNHLQTKLDHIQ 793
++DQ + E+E+ Q L + D++K A ++E + Q +++++
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 794 EQLESKELERQNLETFKDRMTEE-SKVEAELHAER-----IEALRKQFQTERETTKKVAQ 847
+Q E K LE K+R+ +E + +L +R +E +++F K ++
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 848 REVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKA 907
+ E +A EA + + R L + L E++ +N K K +++ +S+K
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKD 1521
Query: 908 NNAQNIERMKQIEKELK-QMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLA-KSQ 965
+ +N+ +++ ++ L+ QME +K Q ++ E + E L+ E+ M A K Q
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT------EDAKLRLEVNMQALKGQ 1575
Query: 966 Y--DASVRNKQQELHLEAERKIRQELENRCQELEETVRH---LKKCKEATENTLKEASVE 1020
+ D R++Q E E R+++++L ELE+ + K+ E LK+ ++
Sbjct: 1576 FERDLQARDEQNE---EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1632
Query: 1021 SEQITANLEEA---HRWFKHRFDGLQLELTKNRLQRP---SGEDRWQEKDQDVKHDVMSN 1074
++ EEA R + + Q EL R R + ++K + ++ D+M
Sbjct: 1633 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 1075 QSVLHRWERKQNLRPMPKKYHSE 1097
Q L ER + + K+ +E
Sbjct: 1693 QEDLAAAERARKQADLEKEELAE 1715
Score = 78.6 bits (192), Expect = 3e-14
Identities = 100/458 (21%), Positives = 195/458 (42%), Gaps = 31/458 (6%)
Query: 59 RGYLEAPDCLEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNI 118
R EA + E+L+ + + E + + K D+ KN L LE+ M+ +K +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-GKNVHELEKSKRALETQMEEMKTQL 1548
Query: 119 FRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQL-RAVKEEEDKAQDE 177
L+ E L+ + A++ + +DL+ + R+QL R + E E + +DE
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Query: 178 VQRLTATLKIASQTKKNAAIIEEELKTTK--RKMNLKIQELRRQLAQEKYLRESLEKSAS 235
R L A++ K + + EL+ + I++LR+ AQ K + LE + +
Sbjct: 1609 --RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 236 AMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKS 295
+ E+ +T + K+ L+ + + L++ + +A+ Q +KEEL +L S
Sbjct: 1667 SR----DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL---AEELAS 1719
Query: 296 DLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSE 355
L+ R + L +E + L+ + EE L E ++ S++ + Q + +E
Sbjct: 1720 SLSGR----NALQDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 356 LSCMLQTVTM-EKARIIADHQ-----AILQVEQKMMTQTFQEQNLLLDAAHASITNELQT 409
L+ T E AR + Q + L + + F+ L+A A + +++
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 410 VQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIAR---LRGELEASMQE 466
EK L + + + + +D K KE E AR L+ +LE + +E
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Query: 467 KKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKV 504
+ + + + QRE+++ + E E K+K+
Sbjct: 1893 SQRINANRRKLQRELDEATES--NEAMGREVNALKSKL 1928
Score = 43.5 bits (101), Expect = 0.001
Identities = 60/307 (19%), Positives = 123/307 (40%), Gaps = 51/307 (16%)
Query: 17 SPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKV 76
S I ATA E +++ + +E L++DL + K+ LE + E+L S
Sbjct: 1667 SRDEIFATAKEN----EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS-- 1720
Query: 77 ISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLK 136
+G+ L+ + L+ I +L+ E + +
Sbjct: 1721 ---------LSGRN---------------ALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 137 DRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAA 196
DR+ ++ ++ N R+ ++ + A+ +++R L+ S+ +
Sbjct: 1757 DRVRKATQQAE--------QLSNELATERSTAQKNESARQQLERQNKELR--SKLHEMEG 1806
Query: 197 IIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVH 256
++ + K+T + KI +L Q+ QE +++ KS K++E+ VE ERK
Sbjct: 1807 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE 1866
Query: 257 ILQQNC-----------IALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLIS 305
++ L ++ + +Q + A +K + EL+ AT ++ + L S
Sbjct: 1867 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Query: 306 KLVEENK 312
KL N+
Sbjct: 1927 KLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 156 bits (395), Expect = 9e-38
Identities = 214/1035 (20%), Positives = 435/1035 (42%), Gaps = 133/1035 (12%)
Query: 100 LVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEH---SKDLKLLHLE 156
+ +M LE ++ + +LQ EK K L+D + + +++ SK+ KLL
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 157 VMNLRQQLRAVKEE-------EDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKM 209
+ +L L +E+ ++K + + L LK ++++ ++ +L+
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 210 NLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSI 269
+ +I +L+ Q+A+ K E+ A L ++ + + K++ L+ + L++ +
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 270 QSAQELLAQEQKKK----EELEIATSQLKSDLTS---RDDLISKLVEENKNLQISFNKEH 322
S + + +K+K EELE ++L+ L S + +L +K +E L+ + ++E
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 323 EENAYLRSEIMSLH-EASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVE 381
+ E+ H +A E+ +Q + + L QT+ E A + + + + Q +
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 382 Q-------KMMTQTFQEQNLLLDA--AHASITNELQTVQNEKTQLQAHLDHLILEHNQCI 432
Q K+ Q + Q+ D A A + +++ +QNE + L+ + I
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA---EGKAI 1311
Query: 433 QKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQER 492
+ A+D L + +Q+ + LL+E+ R + V+ +++ +ER
Sbjct: 1312 KLAKDV-------------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 493 CNLEKEL-----AKNKVDINTLTHNLQTLEEENKHLADQMASLEL-----QQVTSDYHGL 542
+L+ +L AK ++ + T N+Q L + K L D +++E ++ + L
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQ-LSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 543 AQQKVEK------ITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQ 596
QQ EK + ++KN+L E L + + + V + + D L K +
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 597 TKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLE 656
+KYA A+ + L +KEEL RT K A +++ K+D+
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 657 AVEDRENKKVGNFQRQLAEAK------EDNCKVTIMLENVLASHSKMQGALEKVQIELGR 710
K + Q+ E K ED + T + L MQ + + +L
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE--DAKLRLEVNMQALKGQFERDLQA 1589
Query: 711 RDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE---- 766
RD + N+++ ++L+ ++ +++ + E E Q+AL A +
Sbjct: 1590 RDEQ----------NEEKRRQLQRQLHEYETEL---------EDERKQRALAAAAKKKLE 1630
Query: 767 -DNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHA 825
D + L + + A++ +L +Q Q++ + E ++ +D + +K E E A
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK-ENEKKA 1689
Query: 826 ERIEALRKQFQTE---RETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELE 882
+ +EA Q Q + E +K A E EL + L + + R L ++A+LE
Sbjct: 1690 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE 1749
Query: 883 KILESNK----------EKIKNQKTQIKLHLSAKANNAQNIE--------RMKQIEKELK 924
+ LE + K Q Q+ L+ + + AQ E + K++ +L
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Query: 925 QME-LIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAER 983
+ME +K +++ I + ++ +E Q KS + K+ L +E ER
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFD--- 1040
K+ ++ + + ++ V+ LK+ L+EA ES++I AN + R +
Sbjct: 1870 KMAEQYKEQAEKGNARVKQLKR-------QLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 1041 --GLQLELTKNRLQR 1053
G ++ K++L+R
Sbjct: 1923 AMGREVNALKSKLRR 1937
Score = 151 bits (382), Expect = 3e-36
Identities = 206/1016 (20%), Positives = 440/1016 (43%), Gaps = 138/1016 (13%)
Query: 163 QLRAVKEEEDKAQDEVQRLTATLKIA-----------SQTKKNAAIIEEELKTTKRKMNL 211
Q+ +EE +DE+Q+ + A SQ + +++E+L+ + ++
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ-AETELYA 911
Query: 212 KIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQS 271
+ +E+R +LA +K E + A L + ++ G ++ ERK++
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM---------------- 955
Query: 272 AQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSE 331
AQ++L E++ +EE E A +L+ + + + I KL +E + NK +E L
Sbjct: 956 AQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 332 I----MSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMM-- 385
I +L E EKA+ LTK ++ M+ + + + Q + ++++K+
Sbjct: 1015 ISDLTTNLAEEEEKAK----NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 386 TQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTA-V 444
F EQ L A A + +L + E A LD I + N ++K ++ E + +
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130
Query: 445 QKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKT-EKEIVQERCNLEKE----L 499
Q++L AR + E ++K+ L EE E + E+ T + Q+ ++E +
Sbjct: 1131 QEDLDSERAARNKAE-----KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 500 AKNKVDINTLTHNLQTLEEENKH------LADQMASLELQQVTSDYHGLAQQK------- 546
K +D T +H Q E KH L +Q+ + + D + +K
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 547 -VEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQ-NDHLRKMNKYLQTKYAQANS 604
+ + ++K ++ ++ KL+ +V++L+ + + ND + K+ +++ N
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN- 1304
Query: 605 ELSAKRVHLQQ----ADAHLKEVKSIL-ERSKEELSRTVKCRNAALKES---QKLKEDLE 656
E K + L + + L++ + +L E ++++L+ + K R + + +L E++E
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1364
Query: 657 AVEDRE-------------NKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEK 703
A ++ E KK+ +F + +E + +EN+ + + A +K
Sbjct: 1365 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 704 VQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGV 763
++ R E+ L + D +Q V LE + ++ + ++ + + +A
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484
Query: 764 AREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRM------TEES 817
ARE K A+SL +AL+ + +L+ + L++ E ++L + KD + E+S
Sbjct: 1485 AREKETK-ALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKDDVGKNVHELEKS 1540
Query: 818 KVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQK 877
K E E ++ ++ + E + T+ R E+ + F ++ + + +K
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLR--LEVNMQALKGQFER-DLQARDEQNEEK 1597
Query: 878 LAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKN 937
+L++ L + ++++++ Q L +AK K++E +LK +EL D K
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAK----------KKLEGDLKDLELQADSAIKGR 1647
Query: 938 YEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELE 997
E +++ +M + Q+E++ R + E+ A +E E + + LE
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELE---------DARASRDEIFATA-----KENEKKAKSLE 1693
Query: 998 ETVRHLKKCKEATENTLKEASVESEQITAN----------LEEAHRWFKHRFDGLQLELT 1047
+ L++ A E K+A +E E++ L++ R + R L+ EL
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 1048 KNRLQRPSGEDRWQEKDQDVKHDVMSNQSVLHR--WERKQNLRPMPKKYHSEVQRK 1101
+ + + DR ++ Q + +SN+ R ++ ++ R ++ + E++ K
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQ--LSNELATERSTAQKNESARQQLERQNKELRSK 1807
Score = 133 bits (335), Expect = 8e-31
Identities = 189/923 (20%), Positives = 410/923 (44%), Gaps = 107/923 (11%)
Query: 257 ILQQNCIA---LRD----SIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVE 309
++Q+NC A LR+ + + + L Q +++EE++ +L+ + ++L E
Sbjct: 825 VIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKE 884
Query: 310 -ENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKA 368
E K+ Q++ EE L+ ++ + E +A+ + +L K EL +L + +A
Sbjct: 885 LEQKHSQLT-----EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM---EA 936
Query: 369 RIIA--DHQAILQVEQKMMTQTF---QEQNLLLDAAHASITNELQTVQNEKTQLQAHLDH 423
R+ D LQ E+K M Q +EQ +AA + E T + + +L+ +
Sbjct: 937 RLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV 996
Query: 424 LILEHNQCIQKAQDAEKRTA------VQKELLESTIARLRGELEASMQEKKSLLEEKERF 477
+ ++N+ ++ + E+R + ++E + +L+ + E+ + E + L+++E+
Sbjct: 997 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 478 QREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENK----HLADQMASL--- 530
++E+ K ++++ + + +++A + I L L EEE + L D++A
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 531 -----ELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN 585
EL+ SD Q+ ++ ++NK + L +++ L+ +++ D++
Sbjct: 1117 LKKIRELEGHISDL----QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 586 DHLRKMNKY----------------------LQTKYAQANSELSAKRVHLQQADAHLKEV 623
LR + ++ K+AQA EL+ + ++A A+L +
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 624 KSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKV 683
K LE+ +L+ ++ A +E + K+ LEA K + +R AE + K+
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 684 TIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARM 743
+E+V ++ +G K+ ++ S++ ++ ++ + ++ Q +
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 744 LVMEDQHNSEIESLQ------KALGVAREDNRK----LAMSLEQALQTNNHLQTKLDHIQ 793
++DQ + E+E+ Q L + D++K A ++E + Q +++++
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 794 EQLESKELERQNLETFKDRMTEE-SKVEAELHAER-----IEALRKQFQTERETTKKVAQ 847
+Q E K LE K+R+ +E + +L +R +E +++F K ++
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 848 REVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKA 907
+ E +A EA + + R L + L E++ +N K K +++ +S+K
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKD 1528
Query: 908 NNAQNIERMKQIEKELK-QMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLA-KSQ 965
+ +N+ +++ ++ L+ QME +K Q ++ E + E L+ E+ M A K Q
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT------EDAKLRLEVNMQALKGQ 1582
Query: 966 Y--DASVRNKQQELHLEAERKIRQELENRCQELEETVRH---LKKCKEATENTLKEASVE 1020
+ D R++Q E E R+++++L ELE+ + K+ E LK+ ++
Sbjct: 1583 FERDLQARDEQNE---EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1639
Query: 1021 SEQITANLEEA---HRWFKHRFDGLQLELTKNRLQRP---SGEDRWQEKDQDVKHDVMSN 1074
++ EEA R + + Q EL R R + ++K + ++ D+M
Sbjct: 1640 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 1075 QSVLHRWERKQNLRPMPKKYHSE 1097
Q L ER + + K+ +E
Sbjct: 1700 QEDLAAAERARKQADLEKEELAE 1722
Score = 78.6 bits (192), Expect = 3e-14
Identities = 100/458 (21%), Positives = 195/458 (42%), Gaps = 31/458 (6%)
Query: 59 RGYLEAPDCLEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNI 118
R EA + E+L+ + + E + + K D+ KN L LE+ M+ +K +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-GKNVHELEKSKRALETQMEEMKTQL 1555
Query: 119 FRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQL-RAVKEEEDKAQDE 177
L+ E L+ + A++ + +DL+ + R+QL R + E E + +DE
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Query: 178 VQRLTATLKIASQTKKNAAIIEEELKTTK--RKMNLKIQELRRQLAQEKYLRESLEKSAS 235
R L A++ K + + EL+ + I++LR+ AQ K + LE + +
Sbjct: 1616 --RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673
Query: 236 AMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKS 295
+ E+ +T + K+ L+ + + L++ + +A+ Q +KEEL +L S
Sbjct: 1674 SR----DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL---AEELAS 1726
Query: 296 DLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSE 355
L+ R + L +E + L+ + EE L E ++ S++ + Q + +E
Sbjct: 1727 SLSGR----NALQDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 356 LSCMLQTVTM-EKARIIADHQ-----AILQVEQKMMTQTFQEQNLLLDAAHASITNELQT 409
L+ T E AR + Q + L + + F+ L+A A + +++
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 410 VQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIAR---LRGELEASMQE 466
EK L + + + + +D K KE E AR L+ +LE + +E
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Query: 467 KKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKV 504
+ + + + QRE+++ + E E K+K+
Sbjct: 1900 SQRINANRRKLQRELDEATES--NEAMGREVNALKSKL 1935
Score = 43.5 bits (101), Expect = 0.001
Identities = 60/307 (19%), Positives = 123/307 (40%), Gaps = 51/307 (16%)
Query: 17 SPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKV 76
S I ATA E +++ + +E L++DL + K+ LE + E+L S
Sbjct: 1674 SRDEIFATAKEN----EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS-- 1727
Query: 77 ISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLK 136
+G+ L+ + L+ I +L+ E + +
Sbjct: 1728 ---------LSGRN---------------ALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 137 DRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAA 196
DR+ ++ ++ N R+ ++ + A+ +++R L+ S+ +
Sbjct: 1764 DRVRKATQQAE--------QLSNELATERSTAQKNESARQQLERQNKELR--SKLHEMEG 1813
Query: 197 IIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVH 256
++ + K+T + KI +L Q+ QE +++ KS K++E+ VE ERK
Sbjct: 1814 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE 1873
Query: 257 ILQQNC-----------IALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLIS 305
++ L ++ + +Q + A +K + EL+ AT ++ + L S
Sbjct: 1874 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Query: 306 KLVEENK 312
KL N+
Sbjct: 1934 KLRRGNE 1940
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 156 bits (394), Expect = 1e-37
Identities = 229/1084 (21%), Positives = 459/1084 (42%), Gaps = 158/1084 (14%)
Query: 102 NRMCRLESLMQSLKMNIFRLQTE-----------KDLNPQKTAFLKDR------LNAIQE 144
NR+ +E+L L +LQ + ++L + TA ++ L A E
Sbjct: 866 NRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVE 925
Query: 145 EHSKDLKLLHLEVMNLRQQLRAVKE---EEDKAQDEVQ--RLTATLKIASQTKKNAAIIE 199
E + + L E ++Q ++ ++E EE+ A+ ++Q ++T K+ ++ + +
Sbjct: 926 EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILED 985
Query: 200 EELKTTKRKMNL--KIQELRRQLAQEKYLRESLEKSAS---AMLLKIQEMGSTVEVERKQ 254
+ K K K L +I E L +E+ +SL K + AM+ ++E E +R++
Sbjct: 986 QNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE 1045
Query: 255 VHI----LQQNCIALRDSIQSAQ----ELLAQEQKKKEELEIATSQLKSDLTSR------ 300
+ L+ + L D I Q EL Q KK+EEL+ A ++++ + +
Sbjct: 1046 LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105
Query: 301 ----DDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEK---AQVLNDQLTKKC 353
+ IS+L E+ ++ + S NK ++ L E+ +L E + +L K
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR 1165
Query: 354 SELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAH---ASITNELQTV 410
+ +L+ E+A+ H+A +Q ++ +Q +E L+ A++ QT+
Sbjct: 1166 EQEVNILKKTLEEEAKT---HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL 1222
Query: 411 QNEKTQL---------------------QAHLDHLILEHNQCIQ-KAQDAEKRTAVQKEL 448
+NE+ +L +A L L ++ N+ + + + A+K T +Q EL
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282
Query: 449 ------------LESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLE 496
S + + LE+ +Q+ + LL+E+ R + ++ K++ E+ +
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR 1342
Query: 497 KELAKNKVDINTLTHNLQTLEEE----NKHLADQMASLEL-----QQVTSDYHGLAQQKV 547
++L + + + L + TL + K + D + LE +++ D GL+Q+
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402
Query: 548 EKIT------ESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQ 601
EK+ ++K +L E L + + + + + D L K + KYA+
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 602 ANSELSAKRVHLQQADAHLKEVKSI-LERSKEELSRTVKCRNAALKESQKLKEDLEAVED 660
+A+A KE K++ L R+ EE K+ + EDL + +D
Sbjct: 1463 ERDRA--------EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKD 1514
Query: 661 RENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKK 720
K V ++ ++ ++ LE + + A ++++ L ++
Sbjct: 1515 DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF----- 1569
Query: 721 ERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSL----- 775
ERDL Q R ++ E + Q ++ ME +E+E +K +A +KL M L
Sbjct: 1570 ERDL-QGRDEQSEEKKKQLVRQVREME----AELEDERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 776 --EQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRK 833
+ A + + +L +Q Q++ E + ++ + ++K E E + +EA
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK-ENEKKLKSMEAEMI 1683
Query: 834 QFQTE---RETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNK- 889
Q Q E E K+ AQ+E EL + ++ + R L ++A+LE+ LE +
Sbjct: 1684 QLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG 1743
Query: 890 ------EKIKNQKTQI----------KLHLSAKANNAQNIERM-KQIEKELKQME-LIKD 931
+++K QI + H N Q +ER K+++ +L++ME +K
Sbjct: 1744 NTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS 1803
Query: 932 QYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELEN 991
+Y+ I + ++ N KE Q K + K L ++ ER+ ++ ++
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Query: 992 RCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFDGLQLELT--KN 1049
+ + ++ LK+ E E + A+ ++ LE+A D + E++ KN
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA----TETADAMNREVSSLKN 1919
Query: 1050 RLQR 1053
+L+R
Sbjct: 1920 KLRR 1923
Score = 139 bits (350), Expect = 1e-32
Identities = 223/976 (22%), Positives = 425/976 (43%), Gaps = 148/976 (15%)
Query: 156 EVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQE 215
E+M ++L V+E++ A++ RLT + SQ ++E+L+ + ++ + +E
Sbjct: 846 EMMAKEEELVKVREKQLAAEN---RLTEMETLQSQLMAEKLQLQEQLQA-ETELCAEAEE 901
Query: 216 LRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQEL 275
LR +L +K E + A + + +E ++ E+K+ +QQN IQ +E
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKK---MQQN-------IQELEEQ 951
Query: 276 LAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEI--- 332
L EE E A +L+ + + + + KL EE L+ K +E L I
Sbjct: 952 L-------EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEF 1004
Query: 333 -MSLHEASEKAQVLNDQLTKKCSELSCM--------LQTVTMEKAR--------IIADHQ 375
+L E EK++ L K + ++ + Q +EK R ++D
Sbjct: 1005 TTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 376 AILQVEQKMMTQTFQEQNLLLDAAHASITNE----------LQTVQNEKTQLQAHLDHLI 425
A LQ + + ++ L AA A + E ++ ++++ ++LQ L+
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 426 LEHNQCIQKAQD-AEKRTAVQKEL---LESTIAR--LRGELEASMQ-EKKSLLEEKERFQ 478
N+ ++ +D E+ A++ EL L+ST A+ LR + E + KK+L EE + +
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Query: 479 REVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASL-------- 530
++ + ++ Q L ++L + K L QTLE E LA+++ L
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE 1244
Query: 531 -----------ELQQVTSDYHGLAQQKVEKITESKNKLAYENG----------KLQIKVK 569
ELQ ++ + + +K+T+ + +L G KL
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 570 QLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILER 629
LE Q+Q T LQ ++ +K++ L TK Q E ++ R L++ + E K LE+
Sbjct: 1305 ALESQLQD-TQELLQEENRQKLS--LSTKLKQVEDEKNSFREQLEEEE----EAKHNLEK 1357
Query: 630 S-----------KEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNF---QRQLAE 675
K+++ +V C A + +KL++DLE + R +KV + ++
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417
Query: 676 AKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAE 735
+++ + + L++ S ++ +K L + A +ERD + ++ E +
Sbjct: 1418 LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETK 1477
Query: 736 VDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQ 795
AR L + +E+E L K ED L S + ++ + L+ +++Q
Sbjct: 1478 ALS-LARALEEAMEQKAELERLNKQFRTEMED---LMSSKDDVGKSVHELEKSKRALEQQ 1533
Query: 796 LESKELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQ-------TERETTKKVAQR 848
+E + + + LE + + TE++K+ E++ ++A++ QF+ + E KK R
Sbjct: 1534 VEEMKTQLEELED-ELQATEDAKLRLEVN---LQAMKAQFERDLQGRDEQSEEKKKQLVR 1589
Query: 849 EVAELKKAL-DEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKA 907
+V E++ L DE RS+ V+ ++L L +LE ++S KN+ IK +A
Sbjct: 1590 QVREMEAELEDERKQRSMAVA-ARKKLEMDLKDLEAHIDSAN---KNRDEAIKQLRKLQA 1645
Query: 908 NNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYD 967
+MK +EL +++ + E ++ EM LQ+E+ +++
Sbjct: 1646 -------QMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQ 1698
Query: 968 A---------SVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEAS 1018
A + N + L E K R LE R +LEE + + E + LK+A+
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRR--LEARIAQLEEELEEEQGNTELINDRLKKAN 1756
Query: 1019 VESEQITA--NLEEAH 1032
++ +QI NLE +H
Sbjct: 1757 LQIDQINTDLNLERSH 1772
Score = 134 bits (336), Expect = 6e-31
Identities = 194/894 (21%), Positives = 401/894 (44%), Gaps = 133/894 (14%)
Query: 257 ILQQNCIA-----------LRDSIQSAQELLAQEQK---KKEEL-EIATSQLKSD--LTS 299
+LQ+NC A L ++ ++ QE++ K+EEL ++ QL ++ LT
Sbjct: 811 VLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTE 870
Query: 300 RDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCM 359
+ L S+L+ E LQ E E A +A+ L +LT K EL +
Sbjct: 871 METLQSQLMAEKLQLQEQLQAETELCA--------------EAEELRARLTAKKQELEEI 916
Query: 360 LQTVTMEKARIIADHQAI--LQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQL 417
+ +AR+ + + LQ E+K M Q QE L+ ++ Q +Q EK
Sbjct: 917 CHDL---EARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA----RQKLQLEKVTT 969
Query: 418 QAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERF 477
+A L L E Q I + Q+ + A +K+LLE IA L ++ KSL + K +
Sbjct: 970 EAKLKKL--EEEQIILEDQNC--KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKH 1025
Query: 478 QREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTS 537
+ + E+ + +E +EL K + + LE ++ L+DQ+A L+ Q
Sbjct: 1026 EAMITDLEERLRREE-KQRQELEKTR----------RKLEGDSTDLSDQIAELQAQ---- 1070
Query: 538 DYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQT 597
I E K +LA + +LQ + ++EE+ +N L+K+ + L++
Sbjct: 1071 ------------IAELKMQLAKKEEELQAALARVEEEAAQ------KNMALKKIRE-LES 1111
Query: 598 KYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEA 657
+ ++ +L ++R +A+ +++ LE K EL T+ A + K ++++
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171
Query: 658 VEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEK----VQIELGRRDS 713
++ ++ + Q+ E ++ + + L L +++ LEK ++ E G +
Sbjct: 1172 LKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231
Query: 714 EIAGLKKERDLNQQRVQKLEAEVDQWQARM-------LVMEDQHNSEIESLQKALGVARE 766
E+ L + + ++ + +K+EA++ + Q + + D+ L G+ +
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 767 DNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAE 826
+ K + + + + L+++L QE L+ + ++ +L T+ +VE E ++
Sbjct: 1292 SDSKSS----KLTKDFSALESQLQDTQELLQEENRQKLSLS------TKLKQVEDEKNSF 1341
Query: 827 RIEALRKQFQTERETTKKVA--QREVAELKKALDEANFRSVEVSRTNRELRQKL-AELEK 883
R E L ++ + + K++A +VA++KK +++ SV T E+++KL +LE
Sbjct: 1342 R-EQLEEEEEAKHNLEKQIATLHAQVADMKKKMED----SVGCLETAEEVKRKLQKDLEG 1396
Query: 884 ILESNKEKI----KNQKTQIKLH---------LSAKANNAQNIE-RMKQIEKELKQMELI 929
+ + ++EK+ K +KT+ +L L + +A N+E + K+ ++ L + + I
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 930 KDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQEL 989
+Y ++ + + +L + ++ + + + NKQ +E +L
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEME-------DL 1509
Query: 990 ENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFDGLQLELTKN 1049
+ ++ ++V L+K K A E ++E + E++ L +A K R + + L+ K
Sbjct: 1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL-QATEDAKLRLE-VNLQAMKA 1567
Query: 1050 RLQR--PSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQNLRPMPKKYHSEVQRK 1101
+ +R +++ +EK + + V ++ L ERKQ + + E+ K
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELED-ERKQRSMAVAARKKLEMDLK 1620
Score = 100 bits (250), Expect = 6e-21
Identities = 148/693 (21%), Positives = 301/693 (43%), Gaps = 102/693 (14%)
Query: 135 LKDRLNAIQEEH------SKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATL--K 186
L+D +QEE+ S LK + E + R+QL EEE++A+ +++ ATL +
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL----EEEEEAKHNLEKQIATLHAQ 1365
Query: 187 IASQTKK--NAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEM 244
+A KK ++ E + KRK+ ++ L ++ ++ + LEK+ + + ++ ++
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL 1425
Query: 245 GSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQ----KKKEELEIATSQLKSDLTSR 300
++ +R Q+ L + +LLA+E+ K EE + A ++ + T
Sbjct: 1426 LVDLDHQR-------QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478
Query: 301 DDLISKLVE------ENKNLQISFNKEHEENAYLRSEI-MSLHEASEKAQVLNDQLTKKC 353
L L E E + L F E E+ + ++ S+HE + + L Q+
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV---- 1534
Query: 354 SELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNE 413
E+ L+ + E + A A L++E + L A A +LQ +
Sbjct: 1535 EEMKTQLEELEDE---LQATEDAKLRLE------------VNLQAMKAQFERDLQGRDEQ 1579
Query: 414 KTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEE 473
+ + L + E ++ + ++ LE + L ++++ + + +++
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639
Query: 474 KERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQ 533
+ Q ++ +E+ R + E+ LA+ K + L+++E E L +++A+ E
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKEN----EKKLKSMEAEMIQLQEELAAAERA 1695
Query: 534 QVTSDYHGLAQQKVEKITESKNKLAY---ENGKLQIKVKQLEEQVQSFT-DTSLQNDHLR 589
+ + + ++I S K A E +L+ ++ QLEE+++ +T L ND L+
Sbjct: 1696 KRQAQQE--RDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753
Query: 590 KMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQ 649
K N + Q N++L+ +R H Q+ + + LER +EL VK +
Sbjct: 1754 KANLQID----QINTDLNLERSHAQKNE----NARQQLERQNKELK--VKLQEMEGTVKS 1803
Query: 650 KLKEDLEAVEDRENKKVGNFQRQL-AEAKEDNCKVTIMLENVLASHSKMQGALEKVQIEL 708
K K + A+E K+ + QL E KE + V + K++ L +Q++
Sbjct: 1804 KYKASITALE----AKIAQLEEQLDNETKERQA----ACKQVRRTEKKLKDVL--LQVDD 1853
Query: 709 GRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDN 768
RR++E K + D R+++L+ ++++ + E Q+ A
Sbjct: 1854 ERRNAE--QYKDQADKASTRLKQLKRQLEEAE--------------EEAQR----ANASR 1893
Query: 769 RKLAMSLEQALQTNNHLQTKLDHIQEQLESKEL 801
RKL LE A +T + + ++ ++ +L +L
Sbjct: 1894 RKLQRELEDATETADAMNREVSSLKNKLRRGDL 1926
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 155 bits (392), Expect = 2e-37
Identities = 229/1098 (20%), Positives = 485/1098 (44%), Gaps = 122/1098 (11%)
Query: 39 VEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQNEAICAGKTDILWKNCE 98
+EE T +D+ F +K ++ LE ++Q + + +++ I + I
Sbjct: 997 MEENTGETKDE-----FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIF----- 1046
Query: 99 FLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVM 158
L+ L+ +++S+ +L+T+ N + T ++ L + +E K +++ E
Sbjct: 1047 SLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKN 1106
Query: 159 NLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRR 218
+ ++ + D+ + ++L + + ++ ++EE+ ++K+N +I+ L+
Sbjct: 1107 HAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN-EIENLKN 1165
Query: 219 QLAQEKYLRESLEKSASAMLLKIQEMGSTVE---VERKQVHILQQNCIALRDSIQS-AQE 274
+L ++ E +E + K+ E V+ ERK + LQ++ RD ++ +E
Sbjct: 1166 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE 1225
Query: 275 LLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMS 334
+ A + KEEL+IA LK + D+L + E+ + I+ + + L+ EI
Sbjct: 1226 IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI-INTQDLEKSHTKLQEEIPV 1284
Query: 335 LHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNL 394
LHE E+ + N + + E L+ +T + + A +++E+ + + FQE
Sbjct: 1285 LHE--EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQE 1342
Query: 395 LLDAAHASITNELQTVQNEKTQLQAHLDHL---ILEHNQCIQKAQDAEKRTAVQKELLES 451
+ S+T E ++ K L+ D L I E IQ++Q ++++ KE ++
Sbjct: 1343 EI----KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKE-KDN 1397
Query: 452 TIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTH 511
++ E+E + +LL R + E+ K + QE + K +AK K D+ L
Sbjct: 1398 ETTKIVSEMEQFKPKDSALL----RIEIEMLGLSKRL-QESHDEMKSVAKEKDDLQRLQE 1452
Query: 512 NLQTLEEENKHLADQMAS--LELQQVTSDYHGLAQQKVEKITESKNKLAYE--------- 560
LQ+ ++ K ++ + LE ++ H +++ E I E + L+ +
Sbjct: 1453 VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQK 1512
Query: 561 -----NGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQ 615
N KLQ K++++ E+ + F + ++ K+N+ Q K AK LQ
Sbjct: 1513 QLEAINDKLQNKIQEIYEKEEQFNIKQI-SEVQEKVNELKQFK-----EHRKAKDSALQS 1566
Query: 616 ADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAE 675
++ + E+ + L+ S+EE+ +KE +++K EA++ ++ N + +A+
Sbjct: 1567 IESKMLELTNRLQESQEEI-------QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAK 1619
Query: 676 AKEDNCKVTIMLENVLAS----------HSKMQGALEKVQIE------------LGRRDS 713
KE K L+ + H K Q +K+ +E L
Sbjct: 1620 MKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE 1679
Query: 714 EIAGLKKERDLNQQRVQKLEAEVDQWQARM---LVMEDQHNSEIESLQKALGVAREDNRK 770
E+ + KERD + + L+ E DQ + + + + + E++ + L +E K
Sbjct: 1680 EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDK 1739
Query: 771 LAMSLEQALQTNNHLQTKLDHIQEQLESKELE-RQNLETFKDRMTEESKVEAELH---AE 826
L + + +++Q L+H + L++++L+ ++ L + E+ + +L +E
Sbjct: 1740 LRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSE 1799
Query: 827 RIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILE 886
+ + L Q + E + Q ++ ELK + + + + E ++K++E+E++
Sbjct: 1800 KTDKL-SNMQKDLENSNAKLQEKIQELK----ANEHQLITLKKDVNETQKKVSEMEQL-- 1852
Query: 887 SNKEKIKNQKTQI------KLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQ 940
K++IK+Q + L+L+ K + +N+E MK + KE + +++ + + +
Sbjct: 1853 --KKQIKDQSLTLSKLEIENLNLAQKLH--ENLEEMKSVMKERDNLRRVEETLKLERDQL 1908
Query: 941 SLSIQRFVCEMTNLQKEM---QMLAKSQYDA--SVRNKQQELHLEAE------RKIRQEL 989
S+Q +Q+E+ +ML+K + +R K E ++ K + EL
Sbjct: 1909 KESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDEL 1968
Query: 990 ENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKH-RFDGLQLELTK 1048
+ + QEL++ L + KE + K+ + E EQ+ E + + R D QL
Sbjct: 1969 QKKIQELQKKELQLLRVKEDVNMSHKKIN-EMEQLKKQFEAQNLSMQSVRMDNFQL---T 2024
Query: 1049 NRLQRPSGEDRWQEKDQD 1066
+L E R K++D
Sbjct: 2025 KKLHESLEEIRIVAKERD 2042
Score = 145 bits (366), Expect = 2e-34
Identities = 207/1043 (19%), Positives = 459/1043 (44%), Gaps = 161/1043 (15%)
Query: 116 MNIFRLQTEKDLNPQKTAFLKD-----RLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEE 170
MN L TE+ T + RLN +E +++K L E NL+ A++ +
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 171 EDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESL 230
D+ ++ ++ A ++ SQ+K+ ++ +E K+ ++++ + + LR +
Sbjct: 1365 HDQLKEHIRETLAKIQ-ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPK--DSALLRIEI 1421
Query: 231 EK-SASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSI-QSAQELLAQEQKKKEELEI 288
E S L + + +V E+ + LQ+ + D + ++ +E++A+ + +EEL++
Sbjct: 1422 EMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKV 1481
Query: 289 ATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQ 348
A LK + ++L L E+ + + N L+++I ++E E+ +
Sbjct: 1482 AHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNI---- 1537
Query: 349 LTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMM-----TQTFQEQNLLLDAAHASI 403
K+ SE+ + + K A A+ +E KM+ Q QE+ ++ +
Sbjct: 1538 --KQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEM 1595
Query: 404 TNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQK----------------- 446
+ +Q E+ QL+ + ++ + + +K K TAV +
Sbjct: 1596 KRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFET 1655
Query: 447 -----ELLESTIARLRGELEASMQEKKSLLEEKE--RFQREVNKTEKEIVQERC------ 493
E +E+ RL L +++E +S+ +E++ R E K E++ ++E
Sbjct: 1656 QKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITR 1715
Query: 494 NLEKE---------LAKNKVDINTL-------THNLQTLEEENKHLADQMASLEL----- 532
+LEK+ L +++ I+ L T+ + ++++ +H D + + +L
Sbjct: 1716 DLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEE 1775
Query: 533 ----------QQVTSD-YHGLAQQKVEKITESKNKLAYENGKLQIKVKQLE-EQVQSFTD 580
QQ T D G+ +K +K++ + L N KLQ K+++L+ + Q T
Sbjct: 1776 LRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITL 1835
Query: 581 TSLQNDHLRKMNKYLQTKYAQANSELSAKRVHL------QQADAHLKEVKSILER--SKE 632
N+ +K+++ Q K + L+ ++ + Q+ +L+E+KS+++ +
Sbjct: 1836 KKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLR 1895
Query: 633 ELSRTVKCRNAALKES-QKLK-EDLEAVEDRENKKV--GNFQRQLAEAKEDNCKVTIMLE 688
+ T+K LKES Q+ K DLE ++ + ++ + + + +E + TI +
Sbjct: 1896 RVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQIS 1955
Query: 689 NVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMED 748
++ K + L+K EL +++ ++ +K++ +++ +++ ++E Q++A+ L M+
Sbjct: 1956 DIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQS 2015
Query: 749 QHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELER-QNLE 807
R DN +L L ++L+ + + D ++ ES ++ER Q +
Sbjct: 2016 ---------------VRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIA 2060
Query: 808 TFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEV 867
T ++ + + + +R+ + +Q TE K +E+ + +D+
Sbjct: 2061 TLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDD-------- 2112
Query: 868 SRTNRELRQKLA-ELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERM--------KQ 918
+ E +L+ +LEK +E KE ++K +LS ++IE++ +
Sbjct: 2113 ---HYECLNRLSLDLEKEIEFQKE----LSMRVKANLSLPYLQTKHIEKLFTANQRCSME 2165
Query: 919 IEKELKQMELIKDQYQKKNYEQSLSIQRFVCE-MTNLQKEMQMLAKSQY---DASVRNKQ 974
+ +K+++ + K EQ SI +F + + ++K+ ++L K Q+ D V +++
Sbjct: 2166 FHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRE 2225
Query: 975 QELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEE---- 1030
+ K+ Q ++ +E+ K+ +E+ E +Q+ +N +E
Sbjct: 2226 LR-----DLKLNQNMDLHIEEI---------LKDFSESEFPSIKTEFQQVLSNRKEMTQF 2271
Query: 1031 AHRWFKHRFDGLQLELTKNRLQR 1053
W RFD +E KN +Q+
Sbjct: 2272 LEEWLNTRFD---IEKLKNGIQK 2291
Score = 142 bits (358), Expect = 2e-33
Identities = 213/1036 (20%), Positives = 424/1036 (40%), Gaps = 143/1036 (13%)
Query: 104 MCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHS--KDLKLLHLEVMNLR 161
+C LE L+ I LQ E + ++ L++ + + E S +++ L E+ +
Sbjct: 713 LCNLE-----LEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKS 767
Query: 162 QQLRAVKEEEDKAQDEV----QRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELR 217
++L + E+DK EV R+ L+ +TK + A + K+T ++
Sbjct: 768 EELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQ------- 820
Query: 218 RQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLA 277
K L E+ +L + + M + K+ + AL+ + + L
Sbjct: 821 ----NFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ 876
Query: 278 QEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHE 337
++ ++ +E QLK L +RD + + E + + EE L E L +
Sbjct: 877 EKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQ 936
Query: 338 ASEKAQVLNDQLTKKCSE------------------LSCMLQTVTMEKARIIAD------ 373
E Q+ DQL + L +T+ K++I +
Sbjct: 937 LQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLH 996
Query: 374 ------------HQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQN---EKTQLQ 418
Q ++ +++K + Q L D I + + + + EK +LQ
Sbjct: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056
Query: 419 AHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQ 478
L+ +I E Q ++ + T +E L L+ + E QEK ++++
Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116
Query: 479 R------EVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLEL 532
R EV + KE Q+ +++L + +++ + + +E L ++ L L
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNK--ELTL 1174
Query: 533 QQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMN 592
+ + ++ LAQ K+ E+ YE K K +++ +++Q +T + DHLR
Sbjct: 1175 EHMETERLELAQ----KLNEN-----YEEVKSITKERKVLKELQKSFET--ERDHLRGYI 1223
Query: 593 KYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLK 652
+ ++ Q EL +HL++ + E L RS E + + K KL+
Sbjct: 1224 REIEATGLQTKEELKIAHIHLKEHQETIDE----LRRSVSEKTAQIINTQDLEKSHTKLQ 1279
Query: 653 EDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRD 712
E++ + + E + + N ++++E +E ++ ++ E S +E ++ L +
Sbjct: 1280 EEIPVLHE-EQELLPNV-KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF 1337
Query: 713 SEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLA 772
E +Q+ ++ L E D + +E +H+ E +++ L +E K
Sbjct: 1338 QE----------SQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387
Query: 773 MSLEQALQTNNHLQTKLDHIQEQLESK-------ELERQNLETFKDRMTEESKVEAELHA 825
SL + N TK+ EQ + K E+E L +E K A+
Sbjct: 1388 QSLNMKEKDNE--TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK-EK 1444
Query: 826 ERIEALRKQFQTERETTKKVAQREVA---ELKKALDEANFRSVEVSRTNRELRQKLAELE 882
+ ++ L++ Q+E + K+ + VA E ++ L A+ E T ELR L+E E
Sbjct: 1445 DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE 1504
Query: 883 KILESNKEKIK--NQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQ 940
+ + +++++ N K Q K+ + NI+++ ++++++ +++ K +++K
Sbjct: 1505 TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK-EHRKAKDSA 1563
Query: 941 SLSIQRFVCEMTN----LQKEMQMLAKSQYDASVRNKQQELHLE------------AERK 984
SI+ + E+TN Q+E+Q++ K + + ++ Q+ L +E A+ K
Sbjct: 1564 LQSIESKMLELTNRLQESQEEIQIMIKEKEE--MKRVQEALQIERDQLKENTKEIVAKMK 1621
Query: 985 IRQELE---------NRCQELEETVRHLKKCKEATENTLKEASVESEQIT----ANLEEA 1031
QE E N QE + HLK+ E + L+ E+ ++T NLEE
Sbjct: 1622 ESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEM 1681
Query: 1032 HRWFKHRFDGLQLELT 1047
K R D +E T
Sbjct: 1682 RSVTKERDDLRSVEET 1697
Score = 140 bits (354), Expect = 5e-33
Identities = 190/953 (19%), Positives = 427/953 (44%), Gaps = 105/953 (11%)
Query: 144 EEHSKDLKLLHLEVMNLRQQL---RAVKEEEDKAQDEV------QRLTATLKIASQTKKN 194
+EH + + L V Q+ + +++ K Q+E+ Q L +K S+T++
Sbjct: 1245 KEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQET 1304
Query: 195 AAIIE--EELKTTKRKMNLKIQELRRQLAQEKYLRESLE-KSASAMLLKIQEMGSTVEVE 251
+E E TTK L E+ R EK+ E KS + ++ + +EV+
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 252 RKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEEN 311
Q+ + +A QS QE ++K E S+++ +D + ++ E
Sbjct: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ-FKPKDSALLRIEIEM 1423
Query: 312 KNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCM-LQT-------- 362
L + H+E + E L E Q +DQL + E+ L+T
Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAH 1483
Query: 363 -VTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHL 421
E+ I + + L E++ T Q+Q L+A + + N++Q + ++ Q
Sbjct: 1484 CCLKEQEETINELRVNLS-EKETEISTIQKQ---LEAINDKLQNKIQEIYEKEEQFNIKQ 1539
Query: 422 DHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREV 481
+ E +++ ++ K + +ES + L L+ S +E + +++EKE +R
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR-- 1597
Query: 482 NKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHG 541
VQE +E++ K + + ++ +E+ A E Q+ +
Sbjct: 1598 -------VQEALQIERDQLKE--NTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEH 1648
Query: 542 LAQQ-KVEKIT----ESKN----KLAYENGKLQIKVKQLEEQVQSFTDT-SLQNDHLRKM 591
L +Q + +K+ E++N ++ +EN + V + + ++S +T ++ D L++
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKEN 1708
Query: 592 NKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELS---RTVKCRNAALK-E 647
+ T+ + EL +HL++ + +++ I+ E+S + ++ N ALK +
Sbjct: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
Query: 648 SQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIE 707
K++E+L ++ + E K++ M +++ S++K+Q EK+Q E
Sbjct: 1769 DLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQ---EKIQ-E 1824
Query: 708 LGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARED 767
L + ++ LKK+ + Q++V ++E Q +I+ L +
Sbjct: 1825 LKANEHQLITLKKDVNETQKKVSEME---------------QLKKQIKDQSLTLSKLEIE 1869
Query: 768 NRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNL-ETFKDRMTEESKVEAELHAE 826
N LA L + L+ + + D+++ E+ +LER L E+ ++ + +++ EL
Sbjct: 1870 NLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTA 1929
Query: 827 RIEALRKQFQTERETTKKVAQR--EVAELKKALDEANFRSVEVSRTNRELRQKLAELEKI 884
R+ + ++ +T + +K++++ ++++++K LD++ E+ + +EL++K +L ++
Sbjct: 1930 RMLS-KEHKETVDKLREKISEKTIQISDIQKDLDKS---KDELQKKIQELQKKELQLLRV 1985
Query: 885 LE--SNKEKIKNQKTQIK-----LHLSAKANNAQNIERMKQIEKELKQMELI-KDQYQKK 936
E + K N+ Q+K +LS ++ N + K++ + L+++ ++ K++ + +
Sbjct: 1986 KEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELR 2045
Query: 937 NYEQSLSIQR--FVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQ 994
++SL ++R F+ + +M+A+ + + V+ ++ L + ++ + + L +C
Sbjct: 2046 RIKESLKMERDQFIATL------REMIARDRQNHQVK-PEKRLLSDGQQHLTESLREKCS 2098
Query: 995 ELEETVRHLKKCKEATE--NTL-----KEASVESE---QITANLEEAHRWFKH 1037
++E ++ + + E N L KE + E ++ ANL + KH
Sbjct: 2099 RIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKH 2151
Score = 124 bits (311), Expect = 5e-28
Identities = 214/1028 (20%), Positives = 445/1028 (43%), Gaps = 191/1028 (18%)
Query: 194 NAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLL-KIQEMGSTVEVER 252
N + E+L+T K +M LK++E + L + + L +K L+ +I + + V
Sbjct: 509 NLVLDYEQLRTEKEEMELKLKE-KNDLDEFEALERKTKKDQEMQLIHEISNLKNLV---- 563
Query: 253 KQVHILQQNCIALRDSIQSAQELLAQEQKKKEEL-EIATSQLKSDLTSRDDLISKLVEEN 311
K + Q+ L + + S ELL +++ + ++L E SQ ++ + +E+
Sbjct: 564 KHAEVYNQD---LENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDP 620
Query: 312 KNL-QISFNKE------HEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVT 364
K + Q F+ E E+A+LRSE N +L +K EL+ T
Sbjct: 621 KQMKQTLFDAETVALDAKRESAFLRSE--------------NLELKEKMKELA----TTY 662
Query: 365 MEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNE-------KTQL 417
+ I +Q+ L+ ++KM +E L +A IT + + +L
Sbjct: 663 KQMENDIQLYQSQLEAKKKMQVDLEKE----LQSAFNEITKLTSLIDGKVPKDLLCNLEL 718
Query: 418 QAHLDHLILEHNQCIQKAQDAEKRTAVQKEL--LESTIARLRGELEASMQEKKSLLEEKE 475
+ + L E N+ +++ + + + EL L S + RLR E++ +E + EK+
Sbjct: 719 EGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKD 778
Query: 476 RFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLE------------------ 517
+ EV E + L +E+ K K D+ T N ++ +
Sbjct: 779 KLFSEVVHKESRVQ----GLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834
Query: 518 ---EENKHLADQMASL--ELQQVTSDYHGL-----------------AQQKVEKITESKN 555
EEN+ + ++ +L E Q+ S L Q+++ ++ + K
Sbjct: 835 MVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE 894
Query: 556 KLAYENGKLQI----------KVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSE 605
+L + LQ K++Q E+V++ T + D L+++ + LQ + Q S+
Sbjct: 895 QLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ---EKDDLKQLQESLQIERDQLKSD 951
Query: 606 L-----------SAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKED 654
+ R L+ H + + ++ + EE+SR + + + ++
Sbjct: 952 IHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQK 1011
Query: 655 LEAVEDRENKKVGNFQRQLAEAKEDNC---------------KVTIMLENVLASHSKMQG 699
+ ++ +++ + N Q A+ K++ ++ MLE+V+A +++
Sbjct: 1012 MVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKT 1071
Query: 700 ALEKVQIEL---GRRDSEIAG--LKKERDLNQQRVQ---KLEAEVDQWQARMLVMED--- 748
L K IE+ + + + G LKK++++ Q K E E+ + R+ +E+
Sbjct: 1072 DL-KENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLK 1130
Query: 749 QHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTK---LDHIQ-EQLESKELERQ 804
+ + +++ Q+ L +E+ ++ + + N L+ K L+H++ E+LE + +
Sbjct: 1131 EKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNE 1190
Query: 805 NLETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVA---ELKKALDEAN 861
N E K +T+E KV ++ L+K F+TER+ + + A + K+ L A+
Sbjct: 1191 NYEEVKS-ITKERKV--------LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAH 1241
Query: 862 FRSVEVSRTNRELRQKLAE-LEKILESNKEKIKNQKTQIKLH-LSAKANNAQNIERMKQI 919
E T ELR+ ++E +I+ + + + K Q ++ L + N++ + +
Sbjct: 1242 IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSET 1301
Query: 920 EKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHL 979
++ + ++EL+ +Q K+ S ++ R E L ++ Q +SQ + K++
Sbjct: 1302 QETMNELELLTEQSTTKD---STTLARIEMERLRLNEKFQ---ESQEEIKSLTKER---- 1351
Query: 980 EAERKIRQELENRCQELEETVRH-LKKCKEATEN-----TLKEASVESEQITANLEEAHR 1033
+ + I++ LE + +L+E +R L K +E+ +KE E+ +I + +E+
Sbjct: 1352 DNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ--- 1408
Query: 1034 WFKHRFDGL---QLEL--TKNRLQRPSGEDRWQEKDQDVKHDVMSNQSVLHRW--ERKQN 1086
FK + L ++E+ RLQ E + K++D D+ Q VL + K+N
Sbjct: 1409 -FKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKD---DLQRLQEVLQSESDQLKEN 1464
Query: 1087 LRPMPKKY 1094
++ + K+
Sbjct: 1465 IKEIVAKH 1472
Score = 93.6 bits (231), Expect = 9e-19
Identities = 146/723 (20%), Positives = 311/723 (43%), Gaps = 86/723 (11%)
Query: 403 ITNELQTVQNEKTQLQAHLDHL--ILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGEL 460
+ +L+ V E D L +LE +QK Q+ EK + + L+ S+ L+ EL
Sbjct: 355 LKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQN-EKIENLTRMLVTSSSLTLQQEL 413
Query: 461 EASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELAK--NKVDINTL--------- 509
+A + + + K +NK + ++ N+ + +K+ IN L
Sbjct: 414 KAKRKRRVTWCLGK------INKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCS 467
Query: 510 -----THNLQTLEE-----ENKHLADQMASLELQQVTSDYHGLA---------QQKVEKI 550
++ L TL E K L + EL + +DY L ++++E
Sbjct: 468 ESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELK 527
Query: 551 TESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKR 610
+ KN L E L+ K K+ ++++Q + S +L+ + K+ + +ELS+K
Sbjct: 528 LKEKNDLD-EFEALERKTKK-DQEMQLIHEIS----NLKNLVKHAEVYNQDLENELSSKV 581
Query: 611 VHLQQADAHLKEVKSILERSK-EELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNF 669
L++ + +K+++ ++ K E + + ++++ +++K+ L D E + +
Sbjct: 582 ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLF---DAETVAL-DA 637
Query: 670 QRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRV 729
+R+ A + +N ++ ++ + ++ +M+ ++ Q +L + L+KE +
Sbjct: 638 KRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEI 697
Query: 730 QKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKL 789
KL + +D + L+ + +I LQK L E+N L + L L +++
Sbjct: 698 TKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV-ILLSELKSLPSEV 756
Query: 790 DHIQEQLESKELERQNLETFKDRM-----TEESKVEAELHAERIEALRKQFQTERETTKK 844
+ ++++++ K E + + KD++ +ES+V+ L E I + T + K
Sbjct: 757 ERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLL--EEIGKTKDDLATTQSNYKS 814
Query: 845 VAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLS 904
Q E K + + V N + Q++ L K +K + +K LS
Sbjct: 815 TDQ-EFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSK----EAQKFDSSLGALKTELS 869
Query: 905 AKANNAQNIERMKQIEKELKQMELIKDQYQKKN-------YEQSL---SIQRFVCEMTNL 954
K Q E+ +++++ L +ME +K+Q + ++ E++L +Q+ + E+ L
Sbjct: 870 YKTQELQ--EKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL 927
Query: 955 QKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTL 1014
+E L Q S++ ++ +L + + ++ + ++L + LK+ +E T NTL
Sbjct: 928 TQEKDDL--KQLQESLQIERDQLKSDIHDTVNMNIDTQ-EQLRNALESLKQHQE-TINTL 983
Query: 1015 KEASVESEQITANLEEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDVKHDVMSN 1074
K E ++EE K F + + K +D + Q + DV N
Sbjct: 984 KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK-------QDLEAKNTQTLTADVKDN 1036
Query: 1075 QSV 1077
+ +
Sbjct: 1037 EII 1039
Score = 82.4 bits (202), Expect = 2e-15
Identities = 172/855 (20%), Positives = 342/855 (40%), Gaps = 183/855 (21%)
Query: 72 DSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQT-EKDLNP- 129
+ Q+ I ++ I + KTD L + L N +L+ +Q LK N +L T +KD+N
Sbjct: 1785 EQQETIDKLRG--IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET 1842
Query: 130 QKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEED---KAQDEVQRLTATLK 186
QK ++L ++ S L L +E +NL Q+L EE K +D ++R+ TLK
Sbjct: 1843 QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902
Query: 187 IASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGS 246
+ ++LK + ++ + E++++L + L + +++ + KI E
Sbjct: 1903 LE----------RDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISE--- 1949
Query: 247 TVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISK 306
+ Q+ +Q++ +D +Q QE +KKE + ++K D+ I++
Sbjct: 1950 ----KTIQISDIQKDLDKSKDELQKK----IQELQKKE---LQLLRVKEDVNMSHKKINE 1998
Query: 307 LVEENKNLQ---ISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTV 363
+ + K + +S +N L + LHE+ E+ +++ K+ EL + +++
Sbjct: 1999 MEQLKKQFEAQNLSMQSVRMDNFQLTKK---LHESLEEIRIV----AKERDELRRIKESL 2051
Query: 364 TMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDH 423
ME+ + IA + ++ + Q E+ LL D + + K L+ + +
Sbjct: 2052 KMERDQFIATLREMI-ARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSE- 2109
Query: 424 LILEHNQCIQKAQ-DAEKRTAVQKEL--------------------LESTIARLRGELEA 462
+ +H +C+ + D EK QKEL L + R E
Sbjct: 2110 -MDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHR 2168
Query: 463 SMQEKKSLLEE----KERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEE 518
M++ K +L KE +NK E + + E + K K + + H Q +
Sbjct: 2169 IMKKLKYVLSYVTKIKEEQHESINKFEMDFIDE-------VEKQKELLIKIQHLQQDCDV 2221
Query: 519 ENKHLAD----QMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQ 574
++ L D Q L ++++ D+ ++ TE + L+ Q LEE
Sbjct: 2222 PSRELRDLKLNQNMDLHIEEILKDFSESEFPSIK--TEFQQVLSNRKEMTQF----LEEW 2275
Query: 575 VQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEEL 634
+ + D + ++K N + Q N+ + + + + +E + + + E+
Sbjct: 2276 LNTRFDIEKLKNGIQKEND----RICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQD 2331
Query: 635 SRTVKCRNAAL-KESQKLKEDLEA-------VEDRENKKVGNFQRQLAEAKEDNCKVTIM 686
+++K +N L K Q LK L + +D +N V + QL K
Sbjct: 2332 LKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRE------ 2385
Query: 687 LENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEV-------DQW 739
LEN L H + A+ K +S+I ++KE ++ + KL+A+V ++
Sbjct: 2386 LENSL--HEAKESAMHK--------ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKT 2435
Query: 740 QARMLVMEDQ-------HNSEIESLQ--------------------------------KA 760
+ + V++D+ + EIE L+ +
Sbjct: 2436 KETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEV 2495
Query: 761 LGVAREDNRKLAMSLEQAL-----------------------QTNNHLQTKLDHIQEQLE 797
+ + RE+ R+ + + ++ Q L K +HI+ + E
Sbjct: 2496 IRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKE 2555
Query: 798 SKELERQNLETFKDR 812
+L++QN + K +
Sbjct: 2556 ISKLKQQNEQLIKQK 2570
Score = 53.9 bits (128), Expect = 8e-07
Identities = 104/507 (20%), Positives = 203/507 (40%), Gaps = 64/507 (12%)
Query: 99 FLVNRMCRLE--SLMQSLKMNI-FRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHL 155
F N+ C +E +M+ LK + + + +++ + F D ++ ++++ +K+ HL
Sbjct: 2156 FTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHL 2215
Query: 156 EV-----------MNLRQQLRAVKEE--EDKAQDEVQRL-TATLKIASQTKKNAAIIEEE 201
+ + L Q + EE +D ++ E + T ++ S K+ +EE
Sbjct: 2216 QQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEW 2275
Query: 202 LKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQN 261
L T I++L+ + +E + + ++ I M + E E + I ++
Sbjct: 2276 LNT-----RFDIEKLKNGIQKENDRICQVNNFFNNRIIAI--MNESTEFEERSATISKE- 2327
Query: 262 CIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKE 321
++ L ++K E+L LK+ L S ++ ++NKN ++
Sbjct: 2328 ----------WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ-VNPTTQDNKNPHVTSRAT 2376
Query: 322 HEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVE 381
+R SLHEA E A ++ K EL VT + IIA QA +
Sbjct: 2377 QLTTEKIRELENSLHEAKESAMHKESKIIKMQKELE-----VTND---IIAKLQAKVHES 2428
Query: 382 QKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKR 441
K + +T + +L D + +++ K +L +D +++ + +K A K
Sbjct: 2429 NKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL-VKIDLEKMKNAKEFEKEISATKA 2487
Query: 442 TAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNK------------TEKEIV 489
T E + I LR L S Q + + + + + NK K ++
Sbjct: 2488 TV---EYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALI 2544
Query: 490 --QERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKV 547
E LEKE++K K L L N+HL++++ + + + + + H Q
Sbjct: 2545 LKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAH--KQVTC 2602
Query: 548 EKITESKNKLAYENGKLQIKVKQLEEQ 574
E +S + K QI Q +E+
Sbjct: 2603 ENSPKSPKVTGTASKKKQITPSQCKER 2629
Score = 35.8 bits (81), Expect = 0.23
Identities = 42/194 (21%), Positives = 89/194 (45%), Gaps = 22/194 (11%)
Query: 840 ETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQI 899
E K ++E+ +LKK L+E + + + +L Q L E + + + EKI+N +
Sbjct: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401
Query: 900 KLHLSAKANNAQNIERMKQIEKELKQMELIK-----DQYQ------KKNYEQSLSIQR-- 946
S +R +++ L ++ +K DQ+ K ++ S+++ R
Sbjct: 402 VTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREI 461
Query: 947 --FVCEMTNL-QKEMQMLAKSQYDASVRNKQQELHLEAE-RKIRQELENRCQELEETVRH 1002
VC +++ + L++ +++ + + QE ++E+E +R + +N + E+
Sbjct: 462 DESVCSESDVFSNTLDTLSEIEWNPATKLLNQE-NIESELNSLRADYDNLVLDYEQ---- 516
Query: 1003 LKKCKEATENTLKE 1016
L+ KE E LKE
Sbjct: 517 LRTEKEEMELKLKE 530
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 155 bits (391), Expect = 3e-37
Identities = 203/1033 (19%), Positives = 449/1033 (43%), Gaps = 129/1033 (12%)
Query: 155 LEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEE----ELKTTKRKMN 210
L+ +++ +KE+ ++ ++E+ R A K + K ++++E +L+ N
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEE--KMVSLLQEKNDLQLQVQSETEN 901
Query: 211 LKIQELRRQ-LAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSI 269
L E R + L + K L E+ K + L + +EM S + +++ L+ C +L+ I
Sbjct: 902 LMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRN---LEDKCSSLKRDI 958
Query: 270 QSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLR 329
+ L + +K+K E L ++T+ ++ ISKL +E K+LQ + + ++
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 330 SEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIAD----HQAIL------- 378
++ L + + K + D L + + + K ++ D ++I+
Sbjct: 1019 DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ 1078
Query: 379 QVEQKMMTQTFQEQNLL-------------------LDAAHASITNELQTVQNEKTQLQA 419
Q+E+K+ + F+ L L A + E++ + +++
Sbjct: 1079 QIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEK 1138
Query: 420 HLDHLILEHNQCIQKAQDAEKRTAVQKEL---LESTIARLRGEL-EASMQEK---KSLLE 472
L E + ++ ++A T+ Q E+ E+ ++R +L EA++Q + +L +
Sbjct: 1139 QRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198
Query: 473 EKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLEL 532
++ E+ + + + + LEKE ++ K++I+ + N++ L + ++ ++E
Sbjct: 1199 KQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVED 1258
Query: 533 QQVTSDYHGLAQQKVEKITE---SKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLR 589
Q S+ +Q+ + I + K +L +NG+L +V++ E + T + +
Sbjct: 1259 Q--FSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSK------Q 1310
Query: 590 KMNKYLQTKYAQANSELSAKR--VHLQQADAH----LKEVKSILERSKEELSRTVKCRNA 643
+ + L+ Q E AK H Q+ H L+E + +K EL R + N+
Sbjct: 1311 ALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS 1370
Query: 644 ALKESQKLKED--LEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGAL 701
+ + + E ++ E+ E K QR L EA+E+ ++ + ++QG +
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKLAQR-LQEAEENTETANSKCASLEKTKQRLQGEV 1429
Query: 702 EKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKAL 761
E + +L R + A L K++ + + + + ++D+ QA + + E SL L
Sbjct: 1430 EDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAEL----EAAQKESRSLSTEL 1485
Query: 762 GVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEA 821
R ++ LE + N +LQ ++ + EQ+ Q E K ++ E+ K +
Sbjct: 1486 FKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTK-KLVEQEKSDL 1544
Query: 822 ELHAERIEALRKQFQTERETTKKV-AQREVAELKKALDEANF-RSVEVSRTNRELRQKLA 879
++ E +E E E +K + Q E++++K LD + E+ + R ++
Sbjct: 1545 QVALEEVEG-----SLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAE 1599
Query: 880 ELEKILESN----------KEKIKNQKTQIKLHLS-AKANNAQNIERMKQIEKELKQMEL 928
L+ +L++ K+K++ ++++ L + A+ + ++ ++ +LK +L
Sbjct: 1600 ALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL 1659
Query: 929 IKDQYQKKNYEQSLSIQRFVCEMTN--LQKEMQ--MLAKSQYDASVRNKQQEL------- 977
D + N + L Q + E N L +E++ +A Q + + R +QEL
Sbjct: 1660 HLDDALRSN--EDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRV 1717
Query: 978 ---------HLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQI---- 1024
+ ++K+ ++ E+E +++ + +E + + +A++ +E++
Sbjct: 1718 QLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQ 1777
Query: 1025 ---------TANLEEAHRWFKHRFD-GLQLELTKNRLQRPSGEDRWQEKDQDVKHDVMSN 1074
NLE+ + +HR D QL L + Q E+R +E + ++ +
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRG 1837
Query: 1075 QSVL---HRWERK 1084
L H++ERK
Sbjct: 1838 AEALKGAHKYERK 1850
Score = 112 bits (281), Expect = 1e-24
Identities = 153/758 (20%), Positives = 322/758 (42%), Gaps = 73/758 (9%)
Query: 137 DRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLK-----IASQT 191
D L ++++ K+ L +E+ ++ + A+ K++ ++R T++ I ++
Sbjct: 1212 DNLQRVKQKLEKEKSELKMEIDDMASNIEALS----KSKSNIERTCRTVEDQFSEIKAKD 1267
Query: 192 KKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVE 251
++ +I + L K ++ + EL ++ +++ L L KS A+ +++E+ +E E
Sbjct: 1268 EQQTQLIHD-LNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326
Query: 252 RK----QVHILQQN---CIALRDSIQSAQELLAQEQK--KKEELEIATSQLKSDLTSRDD 302
K H LQ + C LR+ + QE A+ Q+ K E+A + K + T
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYE-TDAIQ 1385
Query: 303 LISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTK--KCSELSCM- 359
+L E K L + E S+ SL + ++ Q + L + + S +C
Sbjct: 1386 RTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACAT 1445
Query: 360 -------LQTVTMEKARIIADHQAILQVEQK----MMTQTFQEQNLLLDAAHASITNELQ 408
V E + + + QA L+ QK + T+ F+ +N A+ + ++L+
Sbjct: 1446 LDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRN-----AYEEVVDQLE 1500
Query: 409 TVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKK 468
T++ E LQ + L + + + Q+AEK K+L+E + +L+ +++E +
Sbjct: 1501 TLRRENKNLQEEISDLTEQIAETGKNLQEAEK----TKKLVEQE----KSDLQVALEEVE 1552
Query: 469 SLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQ-- 526
LE +E ++ + + E+ Q + L++++ + +I L N Q E + + D
Sbjct: 1553 GSLEHEE---SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEI 1609
Query: 527 MASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQND 586
+ + ++ G + ++ S ++A L+ QL++ D N+
Sbjct: 1610 RSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNE 1669
Query: 587 HLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALK 646
L++ ++ + EL +V L+Q + + + L + + + + +
Sbjct: 1670 DLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLIN 1729
Query: 647 ESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLE------NVLASHSKMQGA 700
+KL+ D+ + + + +AK+ +M E + A +M+
Sbjct: 1730 TKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789
Query: 701 LEKVQIELGRRDSE-----IAGLKKERDLNQQRVQKLEAEVDQWQAR-MLVMEDQHNSEI 754
LE+ +L R E + G KK+ + RV++LE E+D Q R ++ H +
Sbjct: 1790 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAH--KY 1847
Query: 755 ESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMT 814
E K + E++ K + L+ + + LQ K+ + Q E E E+ N + + R
Sbjct: 1848 ERKVKEMTYQAEEDHKNILRLQDLV---DKLQAKVKSYKRQAEEAE-EQANTQLSRCRRV 1903
Query: 815 EESKVEAELHAERIEALRKQFQTERETTKKVAQREVAE 852
+ EA AER + Q R ++ V +++ E
Sbjct: 1904 QHELEEA---AERADIAESQVNKLRAKSRDVGSQKMEE 1938
Score = 71.6 bits (174), Expect = 4e-12
Identities = 116/611 (18%), Positives = 248/611 (40%), Gaps = 96/611 (15%)
Query: 32 LQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQNEAICAGKTD 91
L QR++ EE T + L+ ++R E D + DL+
Sbjct: 1397 LAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA-------------- 1442
Query: 92 ILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQ---EEHSK 148
C L + + ++ K + Q E + +++ L L ++ EE
Sbjct: 1443 -----CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 149 DLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRK 208
L+ L E NL++++ + E+ + +Q T K+ Q K + + EE++ +
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 209 MNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDS 268
KI ++ +L+Q K E++RK + +
Sbjct: 1558 EESKILRVQLELSQVK-----------------------SELDRKVI-----------EK 1583
Query: 269 IQSAQELLAQEQKKKEELEIATSQLKSDLTSRDD---LISKLVEENKNLQISFNKEHEEN 325
+ ++L Q+ E L+ S L +++ SR+D L K+ + ++I + +
Sbjct: 1584 DEEIEQLKRNSQRAAEALQ---SVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQM 1640
Query: 326 AYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAI-LQVEQKM 384
A + + ++ + +Q+ D + +L L V ++ + + + + +EQ
Sbjct: 1641 AETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTE 1700
Query: 385 MTQTFQEQNLLLDAAHASITNELQT-VQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTA 443
T+ EQ LL + + + T + N K +L+A + E IQ++++AE++
Sbjct: 1701 RTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEK-- 1758
Query: 444 VQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELA--K 501
+K + ++ + + +++++ ER ++ + +T K++ Q R + ++LA
Sbjct: 1759 AKKAITDAAM------MAEELKKEQDTSAHLERMKKNLEQTVKDL-QHRLDEAEQLALKG 1811
Query: 502 NKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKIT-----ESKNK 556
K I L + ++ LE E +Q E + Y ++KV+++T + KN
Sbjct: 1812 GKKQIQKLENRVRELENELD--VEQKRGAEALKGAHKY----ERKVKEMTYQAEEDHKNI 1865
Query: 557 LAYEN--GKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQ 614
L ++ KLQ KVK + Q + + + N L + + Q E +A+R +
Sbjct: 1866 LRLQDLVDKLQAKVKSYKRQAEEAEEQA--NTQLSRCRR------VQHELEEAAERADIA 1917
Query: 615 QADAHLKEVKS 625
++ + KS
Sbjct: 1918 ESQVNKLRAKS 1928
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 153 bits (386), Expect = 1e-36
Identities = 260/1144 (22%), Positives = 493/1144 (43%), Gaps = 144/1144 (12%)
Query: 7 METTVSRPVLSPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPD 66
M+ T SR LS +A A L+Q + EQ + +L ++ KR E +
Sbjct: 240 MKRTESRQHLSVELADAKAK--IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMN 297
Query: 67 CLEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKD 126
L D S ++ ++E + + E V+R ++ K + L+ +
Sbjct: 298 LLSDARSARMY---RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
Query: 127 LNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRL---TA 183
+ + L+D+L + K L L E + L+ +L ++ E D + +++ L
Sbjct: 355 VLLETKTMLEDQLEGTRARSDK-LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413
Query: 184 TLKIASQTKKNAAI-IEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKI- 241
TL++A + + ++ + EL+ R L A +K L + + S+ LLK+
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSE-------APQKSLGHEVNELTSSRLLKLE 466
Query: 242 ---QEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLT 298
Q + TVE R V ++ N + + Q L KK E LE Q K L
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL----SKKVEILENEIVQEKQSLQ 522
Query: 299 SRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSC 358
+ +L L++E L+ + E + +I L + +E L ++ S++S
Sbjct: 523 NCQNLSKDLMKEKAQLEKTIETLRENS---ERQIKILEQENEHLNQTVSSLRQR-SQISA 578
Query: 359 MLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQ 418
+ +EK I H++I + K+ F+++ + + H E +L+
Sbjct: 579 EARVKDIEKENKIL-HESIKETSSKLSKIEFEKRQIKKELEHYKEKGE------RAEELE 631
Query: 419 AHLDHLILEHNQCIQKAQDAEKRTAVQKELLE---STIARLRGELEASMQEKKSLLEEKE 475
L HL E N+ +QK K T + E LE S + R +L+ ++ K+L + E
Sbjct: 632 NELHHLEKE-NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690
Query: 476 RFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLE--LQ 533
++E ++ ++E ++ R N+E + + + L+ ENK L + L+ L+
Sbjct: 691 SLEKENSQLDEENLELRRNVES--------LKCASMKMAQLQLENKELESEKEQLKKGLE 742
Query: 534 QVTSDYHGLAQQKVEKITESKNKLAYENGKLQI-------KVKQLEEQVQSFTDTSLQND 586
+ + + +K E++ S L EN +LQ K++QLE ++Q D ++N
Sbjct: 743 LLKASF-----KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ---DLEMENQ 794
Query: 587 HLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALK 646
L+K + L+ ++ +L + L+Q + L++ K LE+ + L + + ++ L+
Sbjct: 795 TLQKNLEELKIS-SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE 853
Query: 647 ESQKLKEDLEAVEDRENKKVGNFQR---QLAEAKEDN----------CKVTIMLENVLAS 693
E+ +LE +K++G ++ +L E +++N K + L L S
Sbjct: 854 ENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS 913
Query: 694 H----SKMQGALEKVQIELGRRDSEIAGLKKERDLNQQ-----RVQKLEAEVDQWQARML 744
+M LEK+ EL E GL KER L+ + R + LE++++ + L
Sbjct: 914 EKLKTQQMNNDLEKLTHEL-----EKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL 968
Query: 745 VMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQL-------- 796
++++ +I +L+ L + N++L L+ + L+ + D +E++
Sbjct: 969 EIKEE---KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQD--EERMVQSSPPIS 1023
Query: 797 -ESKELERQNLET------FKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQRE 849
E + ER++ ET KDR+ E + A L AE+ +AL+ Q + + ET Q +
Sbjct: 1024 GEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK-QALKTQLK-QLETQNNNLQAQ 1081
Query: 850 VAELKKALDEANFRSVEVSRTNRELRQKLAELE---KILESNKEKIKNQKTQIKLHLSAK 906
+ L++ ++V + N L+ + A+L+ L S + NQ Q+ + S+
Sbjct: 1082 ILALQR-------QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL 1134
Query: 907 ANNAQNIERMKQIEKELKQMELIKD--------QYQKKNYEQSLSIQ-RFVCEMTNLQKE 957
N +++ + ++ K L LIKD + Q YE +S NL+ E
Sbjct: 1135 ENENESVIKEREDLKSLYD-SLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE 1193
Query: 958 MQMLAKSQYDASVRNKQQELHLEAERKIRQE---LENRCQELEETVRHLKKCKEATENTL 1014
+ L + +Y+ ++ K Q LE K+ QE LEN+ E + K C E + L
Sbjct: 1194 HRDL-EDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE-TVAAEYKKLCGE--NDRL 1249
Query: 1015 KEASVESEQITANLEEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDVKHDVMSN 1074
+ + T L+ H+ K + +LE T RL+ + + Q + D+ ++N
Sbjct: 1250 NHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT--RLEAEFSKLKEQYQQLDITSTKLNN 1307
Query: 1075 QSVL 1078
Q L
Sbjct: 1308 QCEL 1311
Score = 77.4 bits (189), Expect = 7e-14
Identities = 130/621 (20%), Positives = 271/621 (43%), Gaps = 100/621 (16%)
Query: 32 LQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQNEAICAGKTD 91
L+ ++ +E + +L+ +L L KR LE L+ + + + K
Sbjct: 782 LESELQDLEMENQTLQKNLEELKISSKR--------LEQLEKENKSLEQETSQLEKDKKQ 833
Query: 92 ILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKD---RLNAIQEEHSK 148
+ +N + ++ ++ + I L+ E ++ K+ RL +++E+ +
Sbjct: 834 LEKENKRLRQQAEIK-DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKE 892
Query: 149 DLKLLHLEV---MNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTT 205
+K +++ + LR+ L + K + + +++++LT L+ K+ ++ +E T
Sbjct: 893 LVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER--LLHDEQSTD 950
Query: 206 KRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIAL 265
R K+ E + + +K L E E+ +A+ +++E + + R+++ +++N AL
Sbjct: 951 DR---YKLLESKLESTLKKSL-EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1006
Query: 266 RDS------IQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLIS-------------- 305
+ +QS+ + ++ K + E + T +L L +D LI
Sbjct: 1007 KQRQDEERMVQSSPPISGEDNKWERESQETTREL---LKVKDRLIEVERNNATLQAEKQA 1063
Query: 306 ------KLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCM 359
+L +N NLQ + L+ + +L + K QV N L + + L
Sbjct: 1064 LKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1123
Query: 360 LQTVTMEKARIIADHQAILQVEQ--KMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQL 417
+ ++++ + +++++++ + K + + + + L+ H +E +++ ++ L
Sbjct: 1124 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1183
Query: 418 QAHLDHLILEH-------NQCI-QKAQ--DAEKRTAVQKE--LLES----TIA----RLR 457
++ +L +EH NQ + QK Q D EK V++E LLE+ T+A +L
Sbjct: 1184 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1243
Query: 458 GELEASMQEKKSLLEEKERFQREVNKTEKEIVQ----ERCNLEKELAKNK-----VDINT 508
GE + LL+E E Q + +K K ++ E+ LE E +K K +DI +
Sbjct: 1244 GENDRLNHTYSQLLKETEVLQTD-HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1302
Query: 509 LTHNLQ---------TLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAY 559
N Q LEEEN+HL DQ+ +L LQ T +E+ ESK+
Sbjct: 1303 TKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRT---------LLEQNMESKDLFHV 1353
Query: 560 ENGKLQIKVKQLEEQVQSFTD 580
E + K+ +L Q + +
Sbjct: 1354 EQRQYIDKLNELRRQKEKLEE 1374
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 152 bits (385), Expect = 1e-36
Identities = 260/1145 (22%), Positives = 493/1145 (43%), Gaps = 145/1145 (12%)
Query: 7 METTVSRPVLSPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPD 66
M+ T SR LS +A A L+Q + EQ + +L ++ KR E +
Sbjct: 240 MKRTESRQHLSVELADAKAK--IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMN 297
Query: 67 CLEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKD 126
L D S ++ ++E + + E V+R ++ K + L+ +
Sbjct: 298 LLSDARSARMY---RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
Query: 127 LNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRL---TA 183
+ + L+D+L + K L L E + L+ +L ++ E D + +++ L
Sbjct: 355 VLLETKTMLEDQLEGTRARSDK-LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413
Query: 184 TLKIASQTKKNAAI-IEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKI- 241
TL++A + + ++ + EL+ R L A +K L + + S+ LLK+
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSE-------APQKSLGHEVNELTSSRLLKLE 466
Query: 242 ---QEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLT 298
Q + TVE R V ++ N + + Q L KK E LE Q K L
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL----SKKVEILENEIVQEKQSLQ 522
Query: 299 SRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSC 358
+ +L L++E L+ + E + +I L + +E L ++ S++S
Sbjct: 523 NCQNLSKDLMKEKAQLEKTIETLRENS---ERQIKILEQENEHLNQTVSSLRQR-SQISA 578
Query: 359 MLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQ 418
+ +EK I H++I + K+ F+++ + + H E +L+
Sbjct: 579 EARVKDIEKENKIL-HESIKETSSKLSKIEFEKRQIKKELEHYKEKGE------RAEELE 631
Query: 419 AHLDHLILEHNQCIQKAQDAEKRTAVQKELLE---STIARLRGELEASMQEKKSLLEEKE 475
L HL E N+ +QK K T + E LE S + R +L+ ++ K+L + E
Sbjct: 632 NELHHLEKE-NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690
Query: 476 RFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLE--LQ 533
++E ++ ++E ++ R N+E + + + L+ ENK L + L+ L+
Sbjct: 691 SLEKENSQLDEENLELRRNVES--------LKCASMKMAQLQLENKELESEKEQLKKGLE 742
Query: 534 QVTSDYHGLAQQKVEKITESKNKLAYENGKLQI-------KVKQLEEQVQSFTDTSLQND 586
+ + + +K E++ S L EN +LQ K++QLE ++Q D ++N
Sbjct: 743 LLKASF-----KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ---DLEMENQ 794
Query: 587 HLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALK 646
L+K + L+ ++ +L + L+Q + L++ K LE+ + L + + ++ L+
Sbjct: 795 TLQKNLEELKIS-SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE 853
Query: 647 ESQKLKEDLEAVEDRENKKVGNFQR---QLAEAKEDN----------CKVTIMLENVLAS 693
E+ +LE +K++G ++ +L E +++N K + L L S
Sbjct: 854 ENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS 913
Query: 694 H----SKMQGALEKVQIELGRRDSEIAGLKKERDLNQQ------RVQKLEAEVDQWQARM 743
+M LEK+ EL E GL KER L+ + R + LE++++ +
Sbjct: 914 EKLKTQQMNNDLEKLTHEL-----EKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS 968
Query: 744 LVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQL------- 796
L ++++ +I +L+ L + N++L L+ + L+ + D +E++
Sbjct: 969 LEIKEE---KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQD--EERMVQSSPPI 1023
Query: 797 --ESKELERQNLET------FKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQR 848
E + ER++ ET KDR+ E + A L AE+ +AL+ Q + + ET Q
Sbjct: 1024 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK-QALKTQLK-QLETQNNNLQA 1081
Query: 849 EVAELKKALDEANFRSVEVSRTNRELRQKLAELE---KILESNKEKIKNQKTQIKLHLSA 905
++ L++ ++V + N L+ + A+L+ L S + NQ Q+ + S+
Sbjct: 1082 QILALQR-------QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS 1134
Query: 906 KANNAQNIERMKQIEKELKQMELIKD--------QYQKKNYEQSLSIQ-RFVCEMTNLQK 956
N +++ + ++ K L LIKD + Q YE +S NL+
Sbjct: 1135 LENENESVIKEREDLKSLYD-SLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV 1193
Query: 957 EMQMLAKSQYDASVRNKQQELHLEAERKIRQE---LENRCQELEETVRHLKKCKEATENT 1013
E + L + +Y+ ++ K Q LE K+ QE LEN+ E + K C E +
Sbjct: 1194 EHRDL-EDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE-TVAAEYKKLCGE--NDR 1249
Query: 1014 LKEASVESEQITANLEEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDVKHDVMS 1073
L + + T L+ H+ K + +LE T RL+ + + Q + D+ ++
Sbjct: 1250 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT--RLEAEFSKLKEQYQQLDITSTKLN 1307
Query: 1074 NQSVL 1078
NQ L
Sbjct: 1308 NQCEL 1312
Score = 77.4 bits (189), Expect = 7e-14
Identities = 130/595 (21%), Positives = 253/595 (42%), Gaps = 64/595 (10%)
Query: 25 ASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKV-ISPIQNE 83
+S+ L++ + +E++TS L D L+ KR +A L+ V I ++ E
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 84 AICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTE-KDLNPQKTAFLKDRLNAI 142
K ++K RL+ L + K + R + K L + + ++L
Sbjct: 866 NKTLSKEIGIYKES------CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKT- 918
Query: 143 QEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEEL 202
++ + DL+ L E+ + + +E D +L + K+ S KK+ I EE++
Sbjct: 919 -QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLES-KLESTLKKSLEIKEEKI 976
Query: 203 KTTKRKMNLKI---QELRRQLAQEKYLRESLEK--SASAMLLKIQEMGSTVEVERKQVHI 257
+ ++ Q+LR++L K E+L++ M+ + ++
Sbjct: 977 AALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQE 1036
Query: 258 LQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQIS 317
+ + ++D + + A Q +K+ L+ QL++ + I L + +LQ
Sbjct: 1037 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096
Query: 318 FNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAI 377
+NA L+ E +L+ S N QL + S L ++V E+ + + + ++
Sbjct: 1097 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1156
Query: 378 LQVEQKMMT----QTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQ 433
++ +K+ Q + ++L+ + H ++ + + ++ E L+ + L+ + Q
Sbjct: 1157 IKDHEKLELLHERQASEYESLI--SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-- 1212
Query: 434 KAQDAEKRTAVQKE--LLES----TIA----RLRGELEASMQEKKSLLEEKERFQREVNK 483
+D EK V++E LLE+ T+A +L GE + LL+E E Q + +K
Sbjct: 1213 --EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD-HK 1269
Query: 484 TEKEIVQ----ERCNLEKELAKNK-----VDINTLTHNLQ---------TLEEENKHLAD 525
K ++ E+ LE E +K K +DI + N Q LEEEN+HL D
Sbjct: 1270 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1329
Query: 526 QMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTD 580
Q+ +L LQ T +E+ ESK+ E + K+ +L Q + +
Sbjct: 1330 QIQTLMLQNRT---------LLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1375
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 151 bits (381), Expect = 4e-36
Identities = 224/1071 (20%), Positives = 441/1071 (41%), Gaps = 154/1071 (14%)
Query: 93 LWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKL 152
L K+ + L + ++E + + + L E + A L A+QE H + L
Sbjct: 953 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012
Query: 153 LHLE----------VMNLRQQ---LRAVKEEEDKAQDEVQR----LTATLKIASQTKKNA 195
L E L QQ L E+E K + +++R L LK+A ++ +
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDM 1072
Query: 196 AIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVER--- 252
+++L K +I L ++ E+ + L+K + +I+E+G +E ER
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR 1132
Query: 253 ----KQVHILQQNCIALRDSIQSA-----------QELLAQEQKKKEELEIATSQLKSDL 297
KQ L + + + ++ A ++ A+ QK + +LE AT Q ++ +
Sbjct: 1133 AKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV 1192
Query: 298 TS----RDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKC 353
+ D +++L E+ NLQ K +E + L+ E L +E L K C
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMC 1252
Query: 354 SELS---CMLQTVTMEKARIIAD---HQAILQVEQKMMTQTFQEQNLLLDAAHASITNEL 407
L L+T E+ R+I D +A LQ E ++ E++ L+ S
Sbjct: 1253 RSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST 1312
Query: 408 QTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEK 467
Q ++ K QL+ ++ + + A+ L S R + + ++
Sbjct: 1313 QQIEELKHQLE-----------------EETKAKNALAHALQSS-----RHDCDLLREQY 1350
Query: 468 KSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQM 527
+ E K QR ++K E+ Q R E + + + LEE K LA ++
Sbjct: 1351 EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQ----------RTEELEEAKKKLAQRL 1400
Query: 528 ASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDH 587
Q ++ K + ++K +L E L + V++ + D
Sbjct: 1401 ------QEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFD- 1453
Query: 588 LRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKE 647
K+ + KY + +EL A + + L +VK++ E S ++L T++ N K
Sbjct: 1454 --KVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQL-ETLRREN---KN 1507
Query: 648 SQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIE 707
Q+ DL K++ ++ + +++ C++ LE AS +G + ++Q+E
Sbjct: 1508 LQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLE 1567
Query: 708 LGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE- 766
L + SE+ E+D ++++ V + M+ ++EI S AL V ++
Sbjct: 1568 LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVE------TMQSTLDAEIRSRNDALRVKKKM 1621
Query: 767 -------------DNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRM 813
NR A SL T L+ H+ + L +E ++ L + R
Sbjct: 1622 EGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRA 1681
Query: 814 TEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRE 873
L AE E QTER ++K+A++E+ + + + + ++ + T ++
Sbjct: 1682 N-------LLQAEIEELWATLEQTER--SRKIAEQELLDASERVQLLHTQNTSLINTKKK 1732
Query: 874 LRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQY 933
L +++L+ +E ++ +N + + K ++ A A+ +++ + L++M
Sbjct: 1733 LENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM------- 1785
Query: 934 QKKNYEQSLSIQRFVCEMTNLQKEMQ-MLAKSQYDASVRNKQQELHLEAE-RKIRQELEN 991
KKN EQ++ K++Q L +++ A K+Q LEA R++ E+EN
Sbjct: 1786 -KKNLEQTV-------------KDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVEN 1831
Query: 992 RCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFDGLQLELTKNRL 1051
+ E V+ L+K E +KE + ++E+ N+ + D LQ ++ +
Sbjct: 1832 EQKRNAEAVKGLRK----HERRVKELTYQTEEDRKNVLR----LQDLVDKLQAKVKSYKR 1883
Query: 1052 QRPSGEDRWQ---EKDQDVKHDVMSNQSVLHRWERKQN-LRPMPKKYHSEV 1098
Q E++ K + ++H++ + E + N LR ++ H+++
Sbjct: 1884 QAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKI 1934
Score = 97.8 bits (242), Expect = 5e-20
Identities = 149/710 (20%), Positives = 307/710 (43%), Gaps = 65/710 (9%)
Query: 89 KTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFL---KDRLNAIQEE 145
+TD L N E + LE + +SL+ + L+T+++ + L + RL E
Sbjct: 1230 ETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGE 1289
Query: 146 HSKDLKLLHLEVMNLRQQLRA----VKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEE- 200
+S+ L V L + +A ++E + + ++E + A ++ + ++ E
Sbjct: 1290 YSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQ 1349
Query: 201 ---------ELKTTKRKMNLKIQELRRQLAQEKYLR-ESLEKSASAMLLKIQEMGSTVEV 250
EL+ K N ++ + R + + R E LE++ + ++QE VE
Sbjct: 1350 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEA 1409
Query: 251 ERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEE 310
+ C +L + Q Q + E A + L + D ++S+ ++
Sbjct: 1410 -------VNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQK 1462
Query: 311 NKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARI 370
+ Q +E+ L +E+ + E++ DQL E + Q ++ +I
Sbjct: 1463 YEETQAELEASQKESRSLSTELFKVKNVYEESL---DQLETLRRENKNLQQEISDLTEQI 1519
Query: 371 IADHQAILQVE--QKMMTQTFQEQNLLLDAAHASITNE---LQTVQNEKTQLQAHLDHLI 425
+ I ++E +K + Q E L+ A AS+ +E + +Q E Q+++ +D I
Sbjct: 1520 AEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1579
Query: 426 LEHNQCIQKAQDAEKRTAVQKELLESTI-ARLRGELEASMQEKK--SLLEEKERFQREVN 482
E ++ I + + R E ++ST+ A +R +A +KK L E E N
Sbjct: 1580 AEKDEEIDQLKRNHTRVV---ETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHAN 1636
Query: 483 KTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASL---ELQQV---- 535
+ E ++ N + L + ++ ++ + L+E+ + ++ A+L E++++
Sbjct: 1637 RLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQ-LAIVERRANLLQAEIEELWATL 1695
Query: 536 --TSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLE---EQVQSFTDTSLQNDHLRK 590
T +A+Q++ +E L +N L K+LE Q+QS + +Q
Sbjct: 1696 EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESR--- 1752
Query: 591 MNKYLQTKYAQANSELSAKRVHLQQ-ADAHLKEVKSILERSKEELS-RTVKCRNAALKES 648
N + K A ++ + A+ + +Q AHL+ +K LE++ ++L R + ALK
Sbjct: 1753 -NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1811
Query: 649 QKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCK-------VTIMLENVLASHSKMQGAL 701
+K + LEA +V N Q++ AEA + K +T E + ++Q +
Sbjct: 1812 KKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLV 1871
Query: 702 EKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHN 751
+K+Q ++ + +++ + N + +KL+ E+++ + R + E Q N
Sbjct: 1872 DKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVN 1921
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 149 bits (376), Expect = 1e-35
Identities = 239/1139 (20%), Positives = 469/1139 (41%), Gaps = 213/1139 (18%)
Query: 122 QTEKDLNPQKTAF--LKDRL---NAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQD 176
+TEK++ K F +KD L A ++E + + L E +L+ Q++A E A++
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 177 EVQRLTAT-------LKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQL--------- 220
+L T +K ++ ++ I EL KRK+ + EL++ +
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969
Query: 221 -AQEKYLRES------------------LEKSASAMLLKIQEMGSTVEVERKQVHILQQN 261
+EK+ E+ L K A+ Q+ ++ E +V+ L +
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 262 CIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKE 321
I L + + L QE+K + +LE A +L+ DL + I + E + L K+
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089
Query: 322 HEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTME-----KARIIADHQ- 375
E + L+S+I E Q L QL KK EL ++ + E +R A+ Q
Sbjct: 1090 EFEISNLQSKI-------EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142
Query: 376 ----------------------AILQVEQK------MMTQTFQEQNLLLDAA-------H 400
A +++ +K M + +E L +A H
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1202
Query: 401 ASITNEL-----------QTVQNEKTQLQAHLDHLILEHNQCIQKAQ------------- 436
A EL Q ++ EK++++ +D L + + + KA+
Sbjct: 1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL-ASNVETVSKAKGNLEKMCRTLEDQ 1261
Query: 437 --DAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCN 494
+ + + Q+ L+ A+ RG L+ E L+EKE ++++ ++ Q+
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQ-RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 495 LEKELAKNKVDINTLTHNLQT-----------LEEENKHLAD-----QMASLELQQVTSD 538
L+++L + N L H LQ+ EEE + A+ A+ E+ Q +
Sbjct: 1321 LKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTK 1380
Query: 539 YHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTS--LQND---------- 586
Y A Q+ E++ E+K KLA + V+ + + S T LQN+
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 587 ----------HLRKMNKYL---QTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEE 633
R +K L + K + ++EL A + + L ++K+ E S ++
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 634 LSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLAS 693
L T+K N K Q+ DL K++ ++ + +++ C++ LE AS
Sbjct: 1501 L-ETLKREN---KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 694 HSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAE-VDQWQARMLVMEDQHNS 752
+G + ++Q+EL + SE+ E+D ++++ V+ Q+ + N
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 753 EIESLQKALGVARE-------DNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQN 805
I +K G E NR A +L T L+ H+ + L S+E ++
Sbjct: 1617 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ 1676
Query: 806 LETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSV 865
L + R A L IE LR + + E ++K+A++E+ + + + + ++
Sbjct: 1677 LAMVERR--------ANLLQAEIEELRATLE-QTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 866 EVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQ 925
+ T ++L +++++ +E ++ +N + + K ++ A A+ +++ + L++
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 926 MELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQM-LAKSQYDASVRNKQQELHLEAE-R 983
M KKN EQ++ K++Q+ L +++ A K+Q LEA R
Sbjct: 1788 M--------KKNMEQTV-------------KDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFDGLQ 1043
++ E+E+ + E V+ L+K E +KE + ++E+ N+ + D LQ
Sbjct: 1827 ELEGEVESEQKRNAEAVKGLRK----HERRVKELTYQTEEDRKNILR----LQDLVDKLQ 1878
Query: 1044 LELTKNRLQRPSGEDRWQ---EKDQDVKHDVMSNQSVLHRWERKQN-LRPMPKKYHSEV 1098
++ + Q E++ K + ++H++ + E + N LR ++ H++V
Sbjct: 1879 AKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 149 bits (376), Expect = 1e-35
Identities = 239/1139 (20%), Positives = 469/1139 (41%), Gaps = 213/1139 (18%)
Query: 122 QTEKDLNPQKTAF--LKDRL---NAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQD 176
+TEK++ K F +KD L A ++E + + L E +L+ Q++A E A++
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 177 EVQRLTAT-------LKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQL--------- 220
+L T +K ++ ++ I EL KRK+ + EL++ +
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969
Query: 221 -AQEKYLRES------------------LEKSASAMLLKIQEMGSTVEVERKQVHILQQN 261
+EK+ E+ L K A+ Q+ ++ E +V+ L +
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 262 CIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKE 321
I L + + L QE+K + +LE A +L+ DL + I + E + L K+
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089
Query: 322 HEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTME-----KARIIADHQ- 375
E + L+S+I E Q L QL KK EL ++ + E +R A+ Q
Sbjct: 1090 EFEISNLQSKI-------EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142
Query: 376 ----------------------AILQVEQK------MMTQTFQEQNLLLDAA-------H 400
A +++ +K M + +E L +A H
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1202
Query: 401 ASITNEL-----------QTVQNEKTQLQAHLDHLILEHNQCIQKAQ------------- 436
A EL Q ++ EK++++ +D L + + + KA+
Sbjct: 1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL-ASNVETVSKAKGNLEKMCRTLEDQ 1261
Query: 437 --DAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCN 494
+ + + Q+ L+ A+ RG L+ E L+EKE ++++ ++ Q+
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQ-RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 495 LEKELAKNKVDINTLTHNLQT-----------LEEENKHLAD-----QMASLELQQVTSD 538
L+++L + N L H LQ+ EEE + A+ A+ E+ Q +
Sbjct: 1321 LKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTK 1380
Query: 539 YHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTS--LQND---------- 586
Y A Q+ E++ E+K KLA + V+ + + S T LQN+
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 587 ----------HLRKMNKYL---QTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEE 633
R +K L + K + ++EL A + + L ++K+ E S ++
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 634 LSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLAS 693
L T+K N K Q+ DL K++ ++ + +++ C++ LE AS
Sbjct: 1501 L-ETLKREN---KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 694 HSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAE-VDQWQARMLVMEDQHNS 752
+G + ++Q+EL + SE+ E+D ++++ V+ Q+ + N
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 753 EIESLQKALGVARE-------DNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQN 805
I +K G E NR A +L T L+ H+ + L S+E ++
Sbjct: 1617 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ 1676
Query: 806 LETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSV 865
L + R A L IE LR + + E ++K+A++E+ + + + + ++
Sbjct: 1677 LAMVERR--------ANLLQAEIEELRATLE-QTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 866 EVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQ 925
+ T ++L +++++ +E ++ +N + + K ++ A A+ +++ + L++
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 926 MELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQM-LAKSQYDASVRNKQQELHLEAE-R 983
M KKN EQ++ K++Q+ L +++ A K+Q LEA R
Sbjct: 1788 M--------KKNMEQTV-------------KDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFDGLQ 1043
++ E+E+ + E V+ L+K E +KE + ++E+ N+ + D LQ
Sbjct: 1827 ELEGEVESEQKRNAEAVKGLRK----HERRVKELTYQTEEDRKNILR----LQDLVDKLQ 1878
Query: 1044 LELTKNRLQRPSGEDRWQ---EKDQDVKHDVMSNQSVLHRWERKQN-LRPMPKKYHSEV 1098
++ + Q E++ K + ++H++ + E + N LR ++ H++V
Sbjct: 1879 AKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 149 bits (376), Expect = 1e-35
Identities = 216/1055 (20%), Positives = 449/1055 (42%), Gaps = 114/1055 (10%)
Query: 122 QTEKDLNPQKTAF--LKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRA-VKEEEDKAQDEV 178
+TEK++ K F +K+ L E K+L+ + ++ + L+ V+ E+D D
Sbjct: 846 ETEKEMATMKEEFGRIKETLEK-SEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904
Query: 179 QRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAML 238
+R Q KN +E ++K +MN ++++ A+ + LE S +
Sbjct: 905 ER-------CDQLIKNKIQLEAKVK----EMNERLEDEEEMNAELTAKKRKLEDECSELK 953
Query: 239 LKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLT 298
I ++ T+ K+ H + L + + E++A+ K+K+ L+ A Q DL
Sbjct: 954 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1013
Query: 299 SRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQ---VLNDQLTKKCSE 355
+D ++ L + L+ + + M L A K + L +
Sbjct: 1014 VEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN 1073
Query: 356 LSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKT 415
L+ +K I + ++ EQ + Q Q++ A + EL+ + +
Sbjct: 1074 DKLQLEEKLKKKEFDINQQNSKIEDEQVLALQ-LQKKLKENQARIEELEEELEAERTARA 1132
Query: 416 QLQAHLDHLILEHNQCIQKAQDAEKRTAVQKEL---LESTIARLRGEL-EASMQEKKSLL 471
+++ L E + ++ ++A T+VQ E+ E+ ++R +L EA++Q + +
Sbjct: 1133 KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1192
Query: 472 EEKERFQREVNKTEKEI---VQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMA 528
+++ V + ++I + + LEKE ++ K++++ +T N++ + + +L +
Sbjct: 1193 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL--EKV 1250
Query: 529 SLELQQVTSDYH---GLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTD----- 580
S L+ ++Y AQ+ + T + KL ENG+L ++++ E + T
Sbjct: 1251 SRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSY 1310
Query: 581 TSLQNDHLRKMNKYLQTKYAQANSELSAK------RVHLQQADAHLKEVKSILERSKEEL 634
T D R++ + + K A A++ SA+ R ++ E++ +L ++ E+
Sbjct: 1311 TQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEV 1370
Query: 635 SR-TVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLAS 693
++ K A++ +++L+E KK+ ++L +A+E V ++ +
Sbjct: 1371 AQWRTKYETDAIQRTEELEE--------AKKKLA---QRLQDAEEAVEAVNAKCSSLEKT 1419
Query: 694 HSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSE 753
++Q +E + +++ R ++ A L K+ Q+ K+ AE W+ + ++ SE
Sbjct: 1420 KHRLQNEIEDLMVDVERSNAAAAALDKK----QRNFDKILAE---WKQKY----EESQSE 1468
Query: 754 IESLQKALGVAREDNRKLAMSLEQALQ-------TNNHLQTKLDHIQEQL-----ESKEL 801
+ES QK + KL + E++L+ N +LQ ++ + EQL EL
Sbjct: 1469 LESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHEL 1528
Query: 802 E--RQNLETFK-DRMTEESKVEAELHAERIEALRKQFQ----------------TERETT 842
E R+ LE K + + + EA L E + LR Q + E E
Sbjct: 1529 EKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQA 1588
Query: 843 KKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLH 902
K+ QR V L+ +LD EV R +++ L E+E L + Q+K
Sbjct: 1589 KRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1648
Query: 903 LSAKANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEM--QM 960
S + ++ + +LK+ I ++ + + L R V E T +++ Q
Sbjct: 1649 QSLLKDTQIQLDDAVRANDDLKENIAIVER-RNNLLQAELEELRAVVEQTERSRKLAEQE 1707
Query: 961 LAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVE 1020
L ++ + + Q + ++K+ +L E+EE V+ + +E + + +A++
Sbjct: 1708 LIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMM 1767
Query: 1021 SEQI-------------TANLEEAHRWFKHRFD-GLQLELTKNRLQRPSGEDRWQEKDQD 1066
+E++ N+E+ + +HR D Q+ L + Q E R +E + +
Sbjct: 1768 AEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGE 1827
Query: 1067 VKHDVMSNQSVLHRWERKQNLRPMPKKYHSEVQRK 1101
++ + N + + RK R Y +E +K
Sbjct: 1828 LEAEQKRNAESV-KGMRKSERRIKELTYQTEEDKK 1861
Score = 143 bits (361), Expect = 8e-34
Identities = 228/1120 (20%), Positives = 456/1120 (40%), Gaps = 152/1120 (13%)
Query: 27 ETFTVLQQRMRIVEEQTSSL---RDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQNE 83
ET + R + +EE+ SL ++DL + E+ +A + + L K+ + +
Sbjct: 863 ETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVK 922
Query: 84 AICAGKTDILWKNCEF------LVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKD 137
+ D N E L + L+ + L++ + +++ EK K L +
Sbjct: 923 EMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 982
Query: 138 RL--------------NAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTA 183
+ A+QE H + L L +E ++ ++ + + K + +V L
Sbjct: 983 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE----EDKVNSLSKSKVKLEQQVDDLEG 1038
Query: 184 TLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQE 243
+L+ Q KK + +L+ KRK+ ++ + + + + LE+ I +
Sbjct: 1039 SLE---QEKK----VRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQ 1091
Query: 244 MGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDL 303
S +E E+ LQ+ + I+ +E L E+ + ++E +L+SDL+ +
Sbjct: 1092 QNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVE----KLRSDLSRELEE 1147
Query: 304 ISKLVEE---NKNLQISFNKEHE----------ENAYLRSE-------------IMSLHE 337
IS+ +EE ++QI NK+ E E A L+ E + L E
Sbjct: 1148 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE 1207
Query: 338 ASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLD 397
+ Q + +L K+ SE L VT +II + +V + + Q E + L+
Sbjct: 1208 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQA-NEYRVKLE 1266
Query: 398 AAHASITN-------------ELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAV 444
A S+ + EL EK L + L L + Q ++ + +
Sbjct: 1267 EAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326
Query: 445 QKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKV 504
K L + R + + ++ + E K QR ++K E+ Q R E + +
Sbjct: 1327 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ--- 1383
Query: 505 DINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKL 564
+ LEE K LA ++ A++ VE + + L +L
Sbjct: 1384 -------RTEELEEAKKKLAQRLQD-------------AEEAVEAVNAKCSSLEKTKHRL 1423
Query: 565 QIKVKQLEEQVQ-SFTDTSLQNDHLRKMNKYL---QTKYAQANSELSAKRVHLQQADAHL 620
Q +++ L V+ S + + R +K L + KY ++ SEL + + + L
Sbjct: 1424 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1483
Query: 621 KEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDN 680
++K+ E S E L T K N L+E DL K V ++ + + +
Sbjct: 1484 FKLKNAYEESLEHL-ETFKRENKNLQEE---ISDLTEQLGEGGKNVHELEKVRKQLEVEK 1539
Query: 681 CKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQ 740
++ LE AS +G + + Q+E + +EI E+D ++ ++ V
Sbjct: 1540 LELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSL 1599
Query: 741 ARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKE 800
L E + +E+ ++K + D ++ + L A + Q ++ +Q L+ +
Sbjct: 1600 QTSLDAETRSRNEVLRVKKKM---EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1656
Query: 801 LERQNLETFKDRMTEESKVEAE----LHAERIEALRKQFQTERETTKKVAQREVAELKKA 856
++ + D + E + L AE E QTER ++K+A++E+ E +
Sbjct: 1657 IQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER--SRKLAEQELIETSER 1714
Query: 857 LDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERM 916
+ + ++ + +++ L +L+ +E ++ +N + + K ++ A A+ +++
Sbjct: 1715 VQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE 1774
Query: 917 KQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQ-MLAKSQYDASVRNKQQ 975
+ L++M KKN EQ++ K++Q L +++ A K+Q
Sbjct: 1775 QDTSAHLERM--------KKNMEQTI-------------KDLQHRLDEAEQIALKGGKKQ 1813
Query: 976 ELHLEAE-RKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRW 1034
LEA R++ ELE + E+V+ ++K +E +KE + ++E+ NL
Sbjct: 1814 LQKLEARVRELEGELEAEQKRNAESVKGMRK----SERRIKELTYQTEEDKKNLLR---- 1865
Query: 1035 FKHRFDGLQLELTKNRLQRPSGEDRWQ---EKDQDVKHDV 1071
+ D LQL++ + Q E++ K + V+H++
Sbjct: 1866 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1905
Score = 95.1 bits (235), Expect = 3e-19
Identities = 138/650 (21%), Positives = 280/650 (43%), Gaps = 70/650 (10%)
Query: 132 TAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQ---LRAVKEEEDKAQDEVQRLT--ATLK 186
T ++D ++EE L H + + R LR EEE +A+ E+QR+ A +
Sbjct: 1311 TQQMEDLKRQLEEEGKAKNALAHA-LQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369
Query: 187 IAS-QTKKNAAIIE--EELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQE 243
+A +TK I+ EEL+ K+K+ ++Q+ + SLEK+ + +I++
Sbjct: 1370 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 244 MGSTVEVER---------KQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLK 294
+ V+VER K+ + + + +Q L QK+ L +LK
Sbjct: 1430 L--MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1487
Query: 295 SDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCS 354
+ + + ENKNLQ + E+ + L + ++ +V +L
Sbjct: 1488 NAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALE 1547
Query: 355 ELSCMLQ-------TVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNEL 407
E L+ +E +I A+ + L + + M Q + ++D+ S+ E
Sbjct: 1548 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAET 1607
Query: 408 QT---VQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASM 464
++ V K +++ L+ + ++ + + A +A+K+ + LL+ T +L + A+
Sbjct: 1608 RSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1667
Query: 465 QEKKSL-LEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHL 523
K+++ + E+ + E V E+ ++LA+ ++ I T + +Q L +N L
Sbjct: 1668 DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQEL-IET-SERVQLLHSQNTSL 1725
Query: 524 ADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIK-VKQLEEQVQSFTDTS 582
+Q +E SD L + E + E +N A E K I + E+++ DTS
Sbjct: 1726 INQKKKME-----SDLTQLQSEVEEAVQECRN--AEEKAKKAITDAAMMAEELKKEQDTS 1778
Query: 583 LQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSI-LERSKEELSRTVKCR 641
HL +M K ++ ++ L E + I L+ K++L +
Sbjct: 1779 A---HLERMKKNMEQT--------------IKDLQHRLDEAEQIALKGGKKQLQKL---- 1817
Query: 642 NAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGAL 701
A ++E L+ +LEA + R + V ++ KE +T E + ++Q +
Sbjct: 1818 EARVRE---LEGELEAEQKRNAESVKGMRKSERRIKE----LTYQTEEDKKNLLRLQDLV 1870
Query: 702 EKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHN 751
+K+Q+++ + +++ + N + +K++ E+D+ + R + E Q N
Sbjct: 1871 DKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1920
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 147 bits (371), Expect = 5e-35
Identities = 227/1129 (20%), Positives = 455/1129 (40%), Gaps = 160/1129 (14%)
Query: 41 EQTSSLRDDLIMLDFGEKRGYLEA-PDCLEDLDSQKVISPIQNEAICAGKTDILWKNCEF 99
++ SL+++L + RG +E L D++SQ + + + G+ +L + +
Sbjct: 1497 KENKSLQEELSLA-----RGTIERLTKSLADVESQVSAQNKEKDTVL-GRLALLQEERDK 1550
Query: 100 LVNRMCR-------LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKL 152
L+ M R L S +SLK+ + L +K+ ++ LK A E + K
Sbjct: 1551 LITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKE 1610
Query: 153 LHLEVMNLRQQLRAVKEEEDKAQDEVQ-----------RLTATLKIASQTKKNAAIIEEE 201
L E L Q V E ++ Q V+ +L +T +T+K E+E
Sbjct: 1611 LQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQE 1670
Query: 202 LKTTKRKMN----------LKIQELRRQLAQE--------KYLRESLEKSASAMLLKIQE 243
++ K KM L+++E +L E K E+L S ++M +++
Sbjct: 1671 MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELER 1730
Query: 244 MGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIA-------------T 290
+ E K+ L +L + +Q + + K+ LE T
Sbjct: 1731 VKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT 1790
Query: 291 SQLKSDLTSRDDL-------ISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQ 343
+ + +D L S+ V K+ + +K+ + + + + + + E+
Sbjct: 1791 QSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIA 1850
Query: 344 VLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLL---LDAAH 400
L ++ K E S QT+ EK +++ E KM+ + + NLL +
Sbjct: 1851 GLEEEKQKN-KEFS---QTLENEKNTLLSQIST-KDGELKMLQEEVTKMNLLNQQIQEEL 1905
Query: 401 ASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGEL 460
+ +T +T + EK L+ L + + E N I ++ ELLES + L+ +
Sbjct: 1906 SRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCV 1965
Query: 461 EASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEEN 520
+EK+ L++EK + + E+ K E +Q +KE NK L L+ ++E
Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQ---GAQKEPG-NKSHAKELQELLKEKQQEV 2021
Query: 521 KHLA-------DQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQ----IKVK 569
K L +++++LE ++ QK +IT+ A E+ K K
Sbjct: 2022 KQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFK 2081
Query: 570 QLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHL-----QQADAHLKEVK 624
L + QS L ++ K+ K LQ+ S++ K L Q + HLKE K
Sbjct: 2082 VLLDDTQSEAARVLADN--LKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK 2139
Query: 625 SI------LERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKE 678
++ L R K L T+ L + K + L+ D ++ F + ++ ++
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Query: 679 DNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQ 738
D +V ++ K A++ + E+ ++ + LK + +++L+ + +
Sbjct: 2200 DRDRV---IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISR 2256
Query: 739 WQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLES 798
+ + E + +E++ QK + +N++L LE+ + Q +L ++ +L+S
Sbjct: 2257 LEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKS 2316
Query: 799 KELERQNLETFKDRMTEES--------KVEAELHAERI--EALRKQFQTERETTKKVAQR 848
+ + +L ++ E+ + EA++ + E L Q RE T ++ +
Sbjct: 2317 LKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEE 2376
Query: 849 EVAELKKALDEANFRSVEVSRTNRELRQK----LAELEKILESNKEKI-----KNQKTQI 899
+ +K + + + + ELRQ+ + ELE +L +E+ +N+K
Sbjct: 2377 INMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
Query: 900 K---LHLSAKANNAQNIERMKQIEKELKQMELIKDQ-------YQKKN-------YEQSL 942
K L + K +NI++ Q++ +K M +++ YQ+ E+
Sbjct: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Query: 943 SIQRFVCEMTNLQKEMQMLAKSQYDAS----------------------VRNKQQELHLE 980
IQ E L++E++ L D + +++ QQ+ LE
Sbjct: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
Query: 981 AERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLE 1029
+ + +ELEN+ +LEE ++ ++ E + E + ++ +E
Sbjct: 2557 VQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIE 2605
Score = 144 bits (362), Expect = 6e-34
Identities = 215/1031 (20%), Positives = 454/1031 (44%), Gaps = 129/1031 (12%)
Query: 20 HINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISP 79
H+ T E L ++ + V++ +L + L + ++ L+D D +VI
Sbjct: 2154 HLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL-----AAFTKSMSSLQD-DRDRVIDE 2207
Query: 80 IQ------NEAICAGKTDILWK--NCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQK 131
+ ++AI + + +I K NC L +++ ++ M+ LK+NI RL+ +K + K
Sbjct: 2208 AKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESK 2267
Query: 132 TAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQT 191
+Q + K L E L QL + +Q+E+ +L + LK
Sbjct: 2268 AQ------TEVQLQQ-KVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQ 2320
Query: 192 KKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVE 251
+ + E+ K K + I++ + K+ E LE A +E+ S + E
Sbjct: 2321 LTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQAS----RELTSRLHEE 2376
Query: 252 RKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEEN 311
+++ +Q I+L + A ++ E +++ + EI +L++ L+ ++ L EEN
Sbjct: 2377 ---INMKEQKIISLLSGKEEAIQVAIAELRQQHDKEI--KELENLLSQEEEENIVLEEEN 2431
Query: 312 KNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARII 371
K N+ E ++ E +KAQ+ D K S L ++ RI+
Sbjct: 2432 KKAVDKTNQLMETLKTIKKE-----NIQQKAQL--DSFVKSMSSLQ-------NDRDRIV 2477
Query: 372 ADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHN-- 429
D+Q Q+E++ ++ ++ L+ +AA E ++ E L++H+D L E+
Sbjct: 2478 GDYQ---QLEERHLSIILEKDQLIQEAAA-----ENNKLKEEIRGLRSHMDDLNSENAKL 2529
Query: 430 --QCIQKAQDAEK----RTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNK 483
+ IQ +D + + + QK+LLE + + + ELE + + L+E E ++ +
Sbjct: 2530 DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNK-ELENKYAKLEEKLKESEEANEDLRR 2588
Query: 484 TEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENK----HLADQMASLELQQVTSDY 539
+ + +E+ +L KE+ KV I+ LT + L+EE H ++ E+ ++++ +
Sbjct: 2589 SFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALF 2648
Query: 540 HGLAQQKVEKI--------TESKNKLAYENGKLQIKVKQLEEQ---VQSFTDTSLQN-DH 587
+Q+++ ++ E+ K+ KL+ ++K L +++ T+T+ +
Sbjct: 2649 SS-SQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAE 2707
Query: 588 LRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKE 647
L + ++ K E +Q + +++ + + EEL + +A+LKE
Sbjct: 2708 LARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKE 2767
Query: 648 SQKLKEDLEAVEDRENKKV---------GNFQRQLAEAKEDNCKVTIMLENVLASHSKMQ 698
+LKE + + +RE + + L+ ++ N ++ E +L S+++
Sbjct: 2768 LAQLKE--QGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLE 2825
Query: 699 GALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQ 758
+ +VQ +A L+ ERD ++K + ++ + R +E++SL+
Sbjct: 2826 DSYNQVQ----SFSKAMASLQNERDHLWNELEKFR-KSEEGKQRSAAQPSTSPAEVQSLK 2880
Query: 759 KALGVAREDNRKLAMSL----EQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMT 814
KA+ + D +L L +Q LQ N + T+L ++ QL+ + + + + ++ +
Sbjct: 2881 KAMSSLQNDRDRLLKELKNLQQQYLQINQEI-TELHPLKAQLQEYQDKTKAFQIMQEELR 2939
Query: 815 EES-KVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRE 873
+E+ + ELH Q + E+ + + +R + A+ + + + + RE
Sbjct: 2940 QENLSWQHELH---------QLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRE 2990
Query: 874 LRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQY 933
LR ++ + + K++ Q+ Q SA + +QN+ E EL + +L +
Sbjct: 2991 LRSSSSQTQPL------KVQYQR-QASPETSASPDGSQNL----VYETELLRTQL--NDS 3037
Query: 934 QKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRC 993
K+ +++ L IQ+ + L +E L+ D S ++ + H +L N C
Sbjct: 3038 LKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHY-------GDLLNHC 3090
Query: 994 QELEETVRHLK 1004
LE+ V+ L+
Sbjct: 3091 AVLEKQVQELQ 3101
Score = 142 bits (357), Expect = 2e-33
Identities = 203/1033 (19%), Positives = 465/1033 (45%), Gaps = 130/1033 (12%)
Query: 143 QEEHSKDLKLLHLE-VMNLRQQLRAVKEEEDKAQDEVQRLTATL--KIASQTKKNAAIIE 199
Q+ S L++ LE + L+ +L +++ K +++V L+ L K A+ TK IIE
Sbjct: 1372 QKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIE 1431
Query: 200 EE--LKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHI 257
+E +K ++ ++ +E ++ Q L+ M K +E+G E R + I
Sbjct: 1432 QEDLIKALHTQLEMQAKEHDERIKQ-------LQVELCEMKQKPEEIG---EESRAKQQI 1481
Query: 258 LQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQIS 317
++ L+ ++ S +E L + + +EEL +A ++ S D+ S++ +NK
Sbjct: 1482 QRK----LQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Query: 318 FNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAI 377
+ A L+ E L +++ + N L+ C L L+ +T +K +++ + +++
Sbjct: 1538 LGRL----ALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL 1593
Query: 378 LQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQ- 436
+ T+ +QE++ L + + + V NE ++Q ++ + E + K +
Sbjct: 1594 KSSKIAESTE-WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652
Query: 437 ------DAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNK---TEKE 487
+ EK+ ++ +E ++R ++ Q+ L EE +R + EV+ T KE
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
Query: 488 ----IVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQM--------------AS 529
++ ++++EL + K++ TL+ Q+L E L++++ A+
Sbjct: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772
Query: 530 LELQQVTSDYHGLAQQKVEKI---TESKNKLAYE-------------------------- 560
LE + + + ++ + I TE ++ L+
Sbjct: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
Query: 561 ---NGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQAD 617
N LQ ++ QL+E++ + +N ++ ++ L+ + S++S K L+
Sbjct: 1833 DEINNYLQ-QIDQLKERIAGLEEEKQKN---KEFSQTLENEKNTLLSQISTKDGELKMLQ 1888
Query: 618 AHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAK 677
+ ++ + ++ +EELSR K + A +E L+E L N +GN+ + + +A+
Sbjct: 1889 EEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ 1948
Query: 678 EDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVD 737
N + ++N+ S+++ +++ E + +SEI E+ Q+ ++
Sbjct: 1949 IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAK 2008
Query: 738 QWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLE--QALQTNNH--LQTKLDHIQ 793
+ Q L+ E Q E++ LQK +E L +++ + +QT + L+ +++
Sbjct: 2009 ELQE--LLKEKQ--QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLA 2064
Query: 794 EQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAEL 853
+ +E ++ + L +FK + + A + A+ ++ L+K+ Q+ +E+ K +++ +L
Sbjct: 2065 QAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLK-LKKELQSNKESVKSQMKQKDEDL 2123
Query: 854 KKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKT--QIKLHLSAKANNAQ 911
++ L++A + L++K EK+ +EK+ ++T +I++ L+ K Q
Sbjct: 2124 ERRLEQAE---------EKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQ 2174
Query: 912 NIER-----MKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQY 966
++ + Q+ K M ++D + E ++F + + ++E+++ +
Sbjct: 2175 QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2234
Query: 967 DASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITA 1026
+ +Q +H+E + LE+ Q E + + ++ +TL+ E++++ +
Sbjct: 2235 VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQG---ENKELLS 2291
Query: 1027 NLEEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQN 1086
LEE +H + Q EL K + S +D+ + +SN S+ E+K N
Sbjct: 2292 QLEET----RHLYHSSQNELAKLESELKSLKDQLTD---------LSN-SLEKCKEQKGN 2337
Query: 1087 LRPMPKKYHSEVQ 1099
L + ++ +++Q
Sbjct: 2338 LEGIIRQQEADIQ 2350
Score = 141 bits (356), Expect = 3e-33
Identities = 239/1188 (20%), Positives = 493/1188 (41%), Gaps = 191/1188 (16%)
Query: 2 DCKVHMETTVSRPVLSPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGY 61
+ +++++ T+S + HI E +Q +V++ +L+D +D
Sbjct: 1057 EIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDL------ 1110
Query: 62 LEAPDCLEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMC--RLESLMQSLKMNIF 119
L+A QK+I+ N G + L K +++ C E L+ I
Sbjct: 1111 LQAEISENQAIIQKLIT--SNTDASDGDSVALVKE-TVVISPPCTGSSEHWKPELEEKIL 1167
Query: 120 RLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQ 179
L+ EK+ L+ +L LK + +LR++L+ K++ ++ Q++
Sbjct: 1168 ALEKEKEQ-------LQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFD 1220
Query: 180 RLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKS--ASAM 237
Q+K+N E + R++ ++++E +ES +
Sbjct: 1221 ---------EQSKEN-----ENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEP 1266
Query: 238 LLKIQEMGSTVEVERKQV------HILQQNCIALRDSIQSAQELLAQEQKKKEELEIATS 291
L K E T V + H + + S+ + L + + +K ELE+ S
Sbjct: 1267 LFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVS 1326
Query: 292 QLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTK 351
S+LT + EE LQ NK+ EI SL S +A+V + L +
Sbjct: 1327 STTSELTKKS-------EEVFQLQEQINKQ-------GLEIESLKTVSHEAEVHAESLQQ 1372
Query: 352 KCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLL------LDAAHASITN 405
K S LQ +E R + Q L QK++++ ++ + L +AA I
Sbjct: 1373 KLE--SSQLQIAGLEHLR---ELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQT 1427
Query: 406 ELQTVQNEKTQLQAHLDHLILEHNQCIQKAQ-DAEKRTAVQKELLESTIAR--LRGELEA 462
E+ ++ L L+ EH++ I++ Q + + +E+ E + A+ ++ +L+A
Sbjct: 1428 EIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQA 1487
Query: 463 SMQEKKSLLEEKERFQREVN---KTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEE 519
++ +K L+E + Q E++ T + + + ++E +++ + +T+ L L+EE
Sbjct: 1488 ALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEE 1547
Query: 520 NKHLADQM--ASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQS 577
L +M + LE Q ++S L + +E +TE K KL E L+ ++
Sbjct: 1548 RDKLITEMDRSLLENQSLSSSCESL-KLALEGLTEDKEKLVKEIESLK------SSKIAE 1600
Query: 578 FTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRT 637
T+ ++ L+K + L Y ++E A+R+ + V + + K+EL
Sbjct: 1601 STEWQEKHKELQKEYEILLQSYENVSNE--AERI---------QHVVEAVRQEKQELYGK 1649
Query: 638 VKCRNAALKESQK----LKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTI-------- 685
++ A KE++K ++++E ++++ K + Q+++ E +E+N ++
Sbjct: 1650 LRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDT 1709
Query: 686 ---MLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVD---QW 739
+E +L+S++ M+ LE+V++E + L E+D + VQ L+ +++
Sbjct: 1710 AKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK 1769
Query: 740 QARMLVMEDQHN----------------SEIESL--------QKALGVAREDNRKLAMSL 775
QA + E N E +SL +++ A+ N ++
Sbjct: 1770 QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDF 1829
Query: 776 EQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEE--------SKVEAEL---- 823
+ NN+LQ ++D ++E++ E E+Q + F + E S + EL
Sbjct: 1830 SSHDEINNYLQ-QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ 1888
Query: 824 ---------------HAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVS 868
R+ L++ + E++ ++ ++AEL ++ +
Sbjct: 1889 EEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ 1948
Query: 869 RTNRELRQKLAELEKI---LESNKEKIKNQKTQIKLHLS----AKANNAQNIERMKQIEK 921
N L ++ L+K LE K+++ +KT+++ + K AQ K K
Sbjct: 1949 IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAK 2008
Query: 922 ELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQML-AKSQYDASVRNKQQELHLE 980
EL+++ K Q K+ + + Q + + K ++ + +SQ D + + +E
Sbjct: 2009 ELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE 2068
Query: 981 AERKIRQELENRCQELEET--------------VRHLKKCKEATENTLKEASVESEQITA 1026
+K + EL + L++T + L+ KE+ ++ +K+ + E+
Sbjct: 2069 HRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLE 2128
Query: 1027 NLEEAH----RWFKHRFDGLQLELTKNRLQRPSGEDR--WQEKDQDVK 1068
EE H + + + D L+ E K L+ GE + +KD++V+
Sbjct: 2129 QAEEKHLKEKKNMQEKLDALRRE--KVHLEETIGEIQVTLNKKDKEVQ 2174
Score = 127 bits (318), Expect = 8e-29
Identities = 230/1079 (21%), Positives = 451/1079 (41%), Gaps = 189/1079 (17%)
Query: 89 KTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSK 148
K ++L + + + +L++SL+ + ++E ++ + ++ EE S+
Sbjct: 811 KIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKV----EELSQ 866
Query: 149 DLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLT--ATLKIASQTKKNAAIIEE------ 200
L LE+ + Q L K + + Q ++ T S T+K + EE
Sbjct: 867 ALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGV 926
Query: 201 ELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQ 260
E+KT K ++NL R + A+++ + E E S S + EM ++ +++
Sbjct: 927 EIKTLKEQLNLLS---RAEEAKKEQVEEDNEVS-SGLKQNYDEMSPAGQISKEE------ 976
Query: 261 NCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDL---ISKLVEENKNLQIS 317
+Q +LL +E ++++ +L++ L +R +L +S+L EE NL+
Sbjct: 977 --------LQHEFDLLKKENEQRKR------KLQAALINRKELLQRVSRLEEELANLKDE 1022
Query: 318 FNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKA----RIIAD 373
KE + R E+ E E + +T KC E+ L+ EK I D
Sbjct: 1023 SKKEIPLSETERGEV---EEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD 1079
Query: 374 HQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQ 433
+ L E++ Q L D TN++ +Q E ++ QA + LI +
Sbjct: 1080 LEEKLAAEEQFQALVKQMNQTLQDK-----TNQIDLLQAEISENQAIIQKLITSNTD--- 1131
Query: 434 KAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTE-------- 485
A D + V++ ++ S E E+K L EKE+ Q + E
Sbjct: 1132 -ASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAI 1190
Query: 486 -KEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLEL------------ 532
K+ ++ +L +EL + K D N L +EN+++ DQ+ L++
Sbjct: 1191 LKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPS 1250
Query: 533 ---QQVTSDYHGLAQQKVEKITE-------------------SKNKLAYENG----KLQI 566
Q+ S GL ++ + K TE S++ A + G +++
Sbjct: 1251 TDQQESCSSTPGL-EEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKA 1309
Query: 567 KVKQLE-EQVQSFTDTSLQNDHLRKMNK---YLQTKYAQANSELSAKRVHLQQADAHLKE 622
++K++E E+V+ S L K ++ LQ + + E+ + + +A+ H +
Sbjct: 1310 QLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAES 1369
Query: 623 VKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCK 682
++ LE S+ +++ L+E Q ++L+ + ++ + V QL+E + K
Sbjct: 1370 LQQKLESSQLQIAGL-----EHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTK 1424
Query: 683 V-TIMLEN---VLASHSKMQ-------GALEKVQIELGRRDSEIAGLKKERDLNQQRVQK 731
+ T ++E + A H++++ ++++Q+EL + + +E QQ +K
Sbjct: 1425 IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRK 1484
Query: 732 LEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDH 791
L+A L+ + E +SLQ+ L +AR +L SL + + D
Sbjct: 1485 LQA--------ALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536
Query: 792 IQEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVA 851
+ +L + ER L T DR S +E + + E+L+ + E +K+ +E+
Sbjct: 1537 VLGRLALLQEERDKLITEMDR----SLLENQSLSSSCESLKLALEGLTEDKEKLV-KEIE 1591
Query: 852 ELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQ 911
LK + + S +E ++L + +IL + E + N+ +I+ H+
Sbjct: 1592 SLKSS-------KIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQ-HV-------- 1635
Query: 912 NIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVR 971
+E ++Q ++EL +L + KK E+ L Q EM ++++M+ AKS+
Sbjct: 1636 -VEAVRQEKQEL-YGKLRSTEANKKETEKQL--QEAEQEMEEMKEKMRKFAKSK------ 1685
Query: 972 NKQQELHLEAER-KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEE 1030
+Q+ L LE E ++R E+ +E + L + + L+ +E E ++
Sbjct: 1686 -QQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLS----- 1739
Query: 1031 AHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDVKHDV---MSNQSVLHRWERKQN 1086
+F L E +D E+ QD+KH + +S Q+ L E+ N
Sbjct: 1740 ------KKFQSLMSE-----------KDSLSEEVQDLKHQIEGNVSKQANLEATEKHDN 1781
Score = 110 bits (274), Expect = 1e-23
Identities = 204/1004 (20%), Positives = 411/1004 (40%), Gaps = 138/1004 (13%)
Query: 160 LRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQ 219
++Q+LR ++ K ++ + L ++ ++++EL +++ + Q+L++
Sbjct: 250 MQQKLRVLQR---KLEEHEESLVGRAQVVD-------LLQQELTAAEQRNQILSQQLQQM 299
Query: 220 LAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQE 279
A+ LR ++E + +++M V + H LQ+ L + + A + A+
Sbjct: 300 EAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAEL 359
Query: 280 QKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENA-YLRSEIMSLHEA 338
+ + LE + K+++ + I L + + LQ + + ++N+ L+ + ++
Sbjct: 360 ESRYSALE---QKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQS 416
Query: 339 SEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDA 398
++ Q L DQL +K E+S L + +++ + Q TQ E+N+
Sbjct: 417 AQTIQQLEDQLQQKSKEISQFLNRLPLQQHETAS--QTSFPDVYNEGTQAVTEENI---- 470
Query: 399 AHASITNELQTVQNEKTQL---QAHLDHLILEHNQ-----CIQKAQD------------- 437
AS+ + ++NEK L L+ L E+ + + +AQ+
Sbjct: 471 --ASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEIS 528
Query: 438 ----AEKRTAVQKE----LLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIV 489
A KR++ +E +LE+T ++ EL + E K EE + ++ E
Sbjct: 529 IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEA 588
Query: 490 QERCNLEKEL----------AKNKVDINTLTHNLQTLEEENKHL---ADQMASLELQQVT 536
+KE+ K KV + + + E L + AS E Q T
Sbjct: 589 DHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRT 648
Query: 537 SDYHGLAQQKVE-KITESKNKLAY------------ENGKLQIKVKQLE---EQVQSFTD 580
S+ L VE K T+ + E +L+ ++ +LE + Q +
Sbjct: 649 SEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYE 708
Query: 581 TSLQN--DHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTV 638
+L + +N+ ++ A++ SA ++ D L +VK + EL V
Sbjct: 709 KNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKEL--SMVTELRAQV 766
Query: 639 KCRNAALKESQKLKE-DLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIM---LENVLASH 694
K L E+++ + D E+ +N EAK + K+ ++ L++V
Sbjct: 767 KQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQF 826
Query: 695 SKMQGALEKVQIELGRRDSEI-AGLKKERDLNQQRVQKLEAEVDQWQARMLVMED---QH 750
S+ + +Q +L ++SE+ G ++ R ++ +V++L + Q + + M+ +
Sbjct: 827 SEQSTLIRSLQSQLQNKESEVLEGAERVRHIS-SKVEELSQALSQKELEITKMDQLLLEK 885
Query: 751 NSEIESLQKALGVAREDNRKLAMSL-EQALQTNNH---LQTKLDHIQEQLESKELERQNL 806
++E+LQ+ + + +++ S+ E+ +Q N L ++ ++EQL L +
Sbjct: 886 KRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQL---NLLSRAE 942
Query: 807 ETFKDRMTEESKVEAELHAERIE------ALRKQFQTERETTKKVAQREVAELKKALDEA 860
E K+++ E+++V + L E +++ Q E + KK ++ +L+ AL
Sbjct: 943 EAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINR 1002
Query: 861 NFRSVEVSRTNRELRQKLAELEK---ILESNKEKIKNQKTQIKLHLSAKANNAQNIE--- 914
VSR EL E +K + E+ + +++ K + + Q IE
Sbjct: 1003 KELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYL 1062
Query: 915 ---------RMKQIEKELKQMELIKDQYQK--KNYEQSL-----SIQRFVCEMTNLQKEM 958
++ I K+L++ ++Q+Q K Q+L I E++ Q +
Sbjct: 1063 KQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAII 1122
Query: 959 QMLAKSQYDASVRNKQQELHLEAERKI-----RQELENRCQELEETVRHLKKCKEATENT 1013
Q L S DAS + L E + E+ ELEE + L+K KE +
Sbjct: 1123 QKLITSNTDAS---DGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKK 1179
Query: 1014 LKEASVESEQITANLEEAHRWFKHRFDGLQLELTKNRLQRPSGE 1057
L+EA + I +E R + Q + NRLQ E
Sbjct: 1180 LQEALTSRKAILKKAQEKERHLREELK--QQKDDYNRLQEQFDE 1221
Score = 81.3 bits (199), Expect = 5e-15
Identities = 162/863 (18%), Positives = 345/863 (39%), Gaps = 128/863 (14%)
Query: 270 QSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLR 329
+ QE LA ++ EL+ Q L +D+ + EE K K
Sbjct: 48 EDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQ---EERKAADNKIKK--------- 95
Query: 330 SEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKM--MTQ 387
+ LH A K LN + + ++ +L T + ++ ++ + E ++ +
Sbjct: 96 ---LKLH-AKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKH 151
Query: 388 TFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKE 447
QE+ L+ A +T Q + Q ++ ++ K+ +KE
Sbjct: 152 KLQEKEELISTLQAQLT---QAQAEQPAQSSTEMEEFVMM------------KQQLQEKE 196
Query: 448 LLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQ--ERCNLEKEL------ 499
ST+ + +A ++ + E+ RF+ +V E E++Q + ++E E+
Sbjct: 197 EFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRV 256
Query: 500 AKNKVD------------INTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKV 547
+ K++ ++ L L E+ N Q+ S +LQQ+ ++++ L
Sbjct: 257 LQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN-----QILSQQLQQMEAEHNTLRNTVE 311
Query: 548 EKITESK---NKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYA---- 600
+ ESK K+ E + ++ L+E++ + Q + + L+++Y+
Sbjct: 312 TEREESKILLEKMELEVAERKLSFHNLQEEMHHLLE---QFEQAGQAQAELESRYSALEQ 368
Query: 601 QANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVED 660
+ +E+ K H+ +E++S + K++ S+ ++ +N +S + + LE
Sbjct: 369 KHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQ 428
Query: 661 RENKKVGNFQRQLAEAKEDNCKVT-----------IMLENVLASHSKMQGALEKVQIELG 709
+++K++ F +L + + T + E +AS K LE + L
Sbjct: 429 QKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALL 488
Query: 710 RRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVME-------DQHNSEIES-----L 757
E+ LK E + ++ LEA+ +A V E ++ +S E L
Sbjct: 489 LSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVL 548
Query: 758 QKALGVAREDNRKLAMSLEQA--------LQTNNHLQTKLDH-IQEQLESKELERQNLET 808
+ ++ L + +++A LQ + DH + +Q E K++E + +
Sbjct: 549 ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAP 608
Query: 809 FKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVS 868
K KV E + + + + K+ A E N VE+
Sbjct: 609 IK------MKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELK 662
Query: 869 RTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNI--ERMKQIEKELKQM 926
T ++ + L+ + I + ++++++ K+QI L L + AQ I + + + KE+ +
Sbjct: 663 STKQDGDKSLSAVPDIGQCHQDELERLKSQI-LELELNFHKAQEIYEKNLDEKAKEISNL 721
Query: 927 ELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHL-EAERKI 985
+ ++++K S + E L +++ L+ + + KQ E++L EAER+
Sbjct: 722 NQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVT-ELRAQVKQLEMNLAEAERQR 780
Query: 986 RQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAH-RWFKHRFDGLQL 1044
R + E+ + A +N L E + S I A ++ ++ D +QL
Sbjct: 781 RLDYES---------------QTAHDNLLTE-QIHSLSIEAKSKDVKIEVLQNELDDVQL 824
Query: 1045 ELTKNRLQRPSGEDRWQEKDQDV 1067
+ ++ S + + Q K+ +V
Sbjct: 825 QFSEQSTLIRSLQSQLQNKESEV 847
Score = 77.0 bits (188), Expect = 9e-14
Identities = 121/593 (20%), Positives = 240/593 (40%), Gaps = 72/593 (12%)
Query: 450 ESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDI--- 506
+ T +R L+ + ++ + E N T +E VQER ++L DI
Sbjct: 20 DDTDQNMRAPLDPELHQESDM---------EFNNTTQEDVQERLAYAEQLVVELKDIIRQ 70
Query: 507 --NTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKL 564
L + L+EE K +++ L+L A+ K+ + + ++ + G +
Sbjct: 71 KDVQLQQKDEALQEERKAADNKIKKLKLH---------AKAKLTSLNKYIEEMKAQGGTV 121
Query: 565 QIKVKQLEEQVQSFTDTSLQND-HLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEV 623
Q EEQ+ +S + + + K+ LQ K +S + L QA A
Sbjct: 122 LPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEK----EELISTLQAQLTQAQAEQPAQ 177
Query: 624 KS-------ILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEA 676
S ++++ +E + A L ++Q + + V +++ F+ Q+
Sbjct: 178 SSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKD----ARFETQV-RL 232
Query: 677 KEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEV 736
ED + +V ++MQ L +Q +L + + G + DL QQ + E
Sbjct: 233 HEDELLQLVTQADV---ETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN 289
Query: 737 DQWQARMLVMEDQHNSEIESLQKALGVAREDNR----KLAMSLEQALQTNNHLQTKLDHI 792
++ ME +HN +L+ + RE+++ K+ + + + + ++LQ ++ H+
Sbjct: 290 QILSQQLQQMEAEHN----TLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHL 345
Query: 793 QEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAE 852
EQ E + LE+ + ++ K E E I +L+K Q + + +
Sbjct: 346 LEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQN--- 402
Query: 853 LKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLS-------- 904
K L + N ++V+ ++T ++L +L + K + ++ Q+ + S
Sbjct: 403 -SKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
Query: 905 AKANNAQNI----ERMKQIEKELKQMELIKDQYQK-KNYEQSLSIQRFVCEMTNLQKEMQ 959
+A +NI +R+ ++E E + L + ++ K + LS Q + E N E
Sbjct: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
Query: 960 MLAKSQYDASVRNKQQELHLEAERKIRQELENR-CQELEETVRHLKKCKEATE 1011
+ NK+ AE + LEN Q+ +E L + KEA E
Sbjct: 522 REVSEISIVDIANKRSS---SAEESGQDVLENTFSQKHKELSVLLLEMKEAQE 571
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 146 bits (369), Expect = 9e-35
Identities = 235/1034 (22%), Positives = 462/1034 (44%), Gaps = 142/1034 (13%)
Query: 135 LKDRLNAIQEEHSK------DLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQ--RLTATLK 186
L D + ++EE + + K + + +L +QL +EE+ A+ ++Q ++TA K
Sbjct: 924 LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL----DEEEGARQKLQLEKVTAEAK 979
Query: 187 IASQTKKNAAIIEEELKTTKRK--MNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEM 244
I ++ + ++ K K K M +I E QLA+E+ ++L K + + I ++
Sbjct: 980 IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL 1039
Query: 245 GSTVEVERKQVHILQQ-------NCIALRDSIQSAQ----ELLAQEQKKKEELEIATSQL 293
++ E K L++ L+D I Q EL Q KK+EEL+ A ++
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARG 1099
Query: 294 KSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKC 353
+ +++ + K+V E LQ + E+ SE S ++A ++ + L+++L
Sbjct: 1100 DDETLHKNNAL-KVVRE---LQAQIAELQED---FESEKASRNKAEKQKRDLSEELEALK 1152
Query: 354 SELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAA--HASITNELQTVQ 411
+EL L T ++ Q + ++++ + +T + + D HA+ EL
Sbjct: 1153 TELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL 1212
Query: 412 NEKTQLQAHLD-----------HLILEHNQCIQ-KAQDAEKRTAVQKELLE-----STIA 454
+ + +A+L+ L E Q KA+ KR + ++ E S
Sbjct: 1213 EQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD 1272
Query: 455 RLRGEL-------EASMQEKKSLLEEKER----FQREVNKTEKEIVQERCNLEKELAKNK 503
RLR EL + + +LLEE E+ F ++ E ++ Q+ L +E + K
Sbjct: 1273 RLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL-QDTQELLQEETRQK 1331
Query: 504 VDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGK 563
+++++ ++ LEEE L +Q E + + LA Q ++ ++K K+ + G
Sbjct: 1332 LNLSS---RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS--QLADTKKKVDDDLGT 1386
Query: 564 LQIK-------VKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRV----- 611
++ +K E Q + +L D L K LQ + +L +R
Sbjct: 1387 IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNL 1446
Query: 612 --HLQQADAHLKEVKSILERSKEELSRTV----KCRNAALKESQKLKEDLEAVED--REN 663
++ D L E KSI R EE R + AL ++ L+E LEA E+ R+N
Sbjct: 1447 EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN 1506
Query: 664 KKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEI-----AGL 718
K++ L +K+D K LE S ++ +E+++ +L + E+ A L
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEK---SKRALEQQVEEMRTQLEELEDELQATEDAKL 1563
Query: 719 KKERDLNQQRVQ-----KLEAEVDQWQARML---VMEDQHNSEIESLQKALGVARE---- 766
+ E ++ + Q + E ++ + R+L V E + E E Q+AL VA +
Sbjct: 1564 RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKME 1623
Query: 767 -DNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHA 825
D + L +E A + + + +L +Q Q++ + E + +D + +SK E+E
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK-ESEKKL 1682
Query: 826 ERIEALRKQFQTE---RETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELE 882
+ +EA Q Q E E ++ A++E EL + + + R L ++A+LE
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 883 KILE---SNKEKIKNQ--KTQIKL-----HLSAKANNAQNIERMKQ-IEKELKQMELIKD 931
+ LE SN E + ++ KT +++ L+A+ + AQ + +Q +E++ K+++
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 932 QYQ---KKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDAS--VRNKQQEL-----HLEA 981
+ + K ++ ++S ++ L+++++ AK + A+ VR +++L +E
Sbjct: 1803 ELEGAVKSKFKATISALE--AKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVED 1860
Query: 982 ERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFDG 1041
ER+ + + + ++ ++ LK+ E E A+ ++ L++A +G
Sbjct: 1861 ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDA----TEANEG 1916
Query: 1042 LQLELT--KNRLQR 1053
L E++ KNRL+R
Sbjct: 1917 LSREVSTLKNRLRR 1930
Score = 143 bits (361), Expect = 8e-34
Identities = 205/949 (21%), Positives = 412/949 (43%), Gaps = 151/949 (15%)
Query: 212 KIQELRRQLAQEKYLRESLEKSASAMLLKIQEM-----GSTVEVERKQVHILQQNCIALR 266
K++ L + QE+ L+ E+ LLK++E G E+ERK +L++ I L
Sbjct: 840 KVKPLLQVTRQEEELQAKDEE-----LLKVKEKQTKVEGELEEMERKHQQLLEEKNI-LA 893
Query: 267 DSIQSAQELLAQEQK-------KKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFN 319
+ +Q+ EL A+ ++ KK+ELE ++ DL SR + EE + QI N
Sbjct: 894 EQLQAETELFAEAEEMRARLAAKKQELE----EILHDLESR------VEEEEERNQILQN 943
Query: 320 KEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQ 379
++ + A+++ L E Q L QL K +E E+ ++ D +
Sbjct: 944 EKKKMQAHIQDLEEQLDEEEGARQKL--QLEKVTAEAKIKKME---EEILLLEDQNSKFI 998
Query: 380 VEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAE 439
E+K+M E + L A L ++N++ + + L+ + + + Q+ + A+
Sbjct: 999 KEKKLMEDRIAECSSQL-AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAK 1057
Query: 440 KRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQER------C 493
++ + L+ IA L+ +++ + K L +++E Q + + + E + +
Sbjct: 1058 RKLDGETTDLQDQIAELQAQID---ELKLQLAKKEEELQGALARGDDETLHKNNALKVVR 1114
Query: 494 NLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITES 553
L+ ++A+ + D + + E++ + L++++ +L+ + + AQQ++ T+
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR--TKR 1172
Query: 554 KNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHL 613
+ ++A L+ + K E Q+Q ++ ++A A ELS +
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQD-----------------MRQRHATALEELSEQLEQA 1215
Query: 614 QQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQL 673
++ A+L++ K LE +EL+ VK ES+ ++ L+A + KV R
Sbjct: 1216 KRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275
Query: 674 AEAKEDNCKVTIMLENV------------------LASHSKMQGALEKVQIELGRR---D 712
E E K+ L+NV + S++Q E +Q E ++
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 713 SEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVME----------DQHNSEIESLQKALG 762
S I L++E++ Q++ ++ E + ++L ++ D IESL++A
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 763 VAREDNRKLAMSLEQAL-------QTNNHLQTKLDHIQEQLESKELERQNLE----TFKD 811
+D L+ LE+ +T N LQ +LD + L+ + NLE F
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 812 RMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTN 871
+ EE + A ER A E E +K + + L +AL+EA E R N
Sbjct: 1456 LLAEEKSISARYAEERDRA-------EAEAREK--ETKALSLARALEEALEAKEEFERQN 1506
Query: 872 RELR--------------QKLAELEKILESNKEKIKNQKTQ-------IKLHLSAKANNA 910
++LR + + ELEK + +++++ +TQ ++ AK
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE 1566
Query: 911 QNIERMK-QIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDAS 969
N++ MK Q E++L+ + +Q ++K ++ E+ + +K+ + S+
Sbjct: 1567 VNMQAMKAQFERDLQTRD---EQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKME 1623
Query: 970 VRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLE 1029
+ K E +EA K R E+ + ++L+ ++ ++ L+EA ++I A +
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR-------ELEEARASRDEIFAQSK 1676
Query: 1030 EAHRWFKHRFDGLQLELTKNRLQRPSGE--DRWQEKDQDVKHDVMSNQS 1076
E+ + K L+ E+ + + + S E R E+++D D ++N +
Sbjct: 1677 ESEKKLK----SLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Score = 142 bits (357), Expect = 2e-33
Identities = 188/888 (21%), Positives = 389/888 (43%), Gaps = 130/888 (14%)
Query: 107 LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHS------KDLKLLHLEVMN- 159
LE+L L+ + +++L ++ + + A++EE +D++ H +
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEE 1207
Query: 160 LRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQ 219
L +QL K + + Q L K + K ++ E + ++K++ ++QEL +
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAK 1267
Query: 220 LAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQE 279
+++ LR L + AS + ++ + + +E K+ ++ +L +Q QELL +E
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE 1327
Query: 280 QKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHE-- 337
++ K +L+SR I +L EE +LQ +E E L ++++L
Sbjct: 1328 TRQ-----------KLNLSSR---IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373
Query: 338 ASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLD 397
A K +V +D T ++++ K +++ D +A ++Q +E+ L D
Sbjct: 1374 ADTKKKVDDDLGT---------IESLEEAKKKLLKDAEA--------LSQRLEEKALAYD 1416
Query: 398 AAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELL--ESTIA- 454
++ K +LQ LD L ++ + Q A + EK+ +LL E +I+
Sbjct: 1417 -----------KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 455 -----RLRGELEASMQEKKSL---------LEEKERFQREVNKTEKEIVQERCNLEKELA 500
R R E EA +E K+L LE KE F+R+ NK Q R ++E +L
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQ-NK------QLRADME-DLM 1517
Query: 501 KNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKL-AY 559
+K D+ N+ LE+ + L Q+ + Q + E +++L A
Sbjct: 1518 SSKDDVG---KNVHELEKSKRALEQQVEEMRTQ----------------LEELEDELQAT 1558
Query: 560 ENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAH 619
E+ KL+++V + Q D +++ + + L + + +EL +R A A
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618
Query: 620 LKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKED 679
K+++ L+ + ++ K R+ +K+ +KL+ ++ + + + A++KE
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678
Query: 680 NCKV------TIMLENVLASHSKMQGALEKVQIELGRRDSEIA----GLKKERDLNQQRV 729
K+ + L+ LAS + + E+ + EL + A L E+ + R+
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Query: 730 QKLEAEVDQWQARMLVMEDQHNS---EIESLQKALGVAREDNRKLAMSLEQALQTNNHLQ 786
+LE E+++ Q+ M ++ D+ ++++L L R +K + +Q + N L+
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK 1798
Query: 787 TKLDHIQEQLESK-------------ELERQNLETFKDRMTEES---KVEAELHA--ERI 828
KL ++ ++SK +LE Q + K+R + E +L ++
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858
Query: 829 EALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESN 888
E R+ +E +K A + +LK+ L+EA + + + R+L+++L + + E
Sbjct: 1859 EDERRHADQYKEQMEK-ANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGL 1917
Query: 889 KEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKK 936
++ K +++ +++++ R Q+ E +EL D + K
Sbjct: 1918 SREVSTLKNRLRRGGPISFSSSRSGRR--QLHLEGASLELSDDDTESK 1963
Score = 125 bits (314), Expect = 2e-28
Identities = 167/861 (19%), Positives = 385/861 (44%), Gaps = 66/861 (7%)
Query: 272 AQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSE 331
A++ A++Q++ L++ + L R ++ + K L + ++ EE E
Sbjct: 802 ARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPL-LQVTRQEEELQAKDEE 860
Query: 332 IMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQE 391
++ + E K + +++ +K +L L+ + ++ A+ + + E+ ++
Sbjct: 861 LLKVKEKQTKVEGELEEMERKHQQL---LEEKNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 392 QNL--LLDAAHASITNEL---QTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQK 446
Q L +L + + E Q +QNEK ++QAH+ L + + + + A ++ ++K
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL----EEQLDEEEGARQKLQLEK 973
Query: 447 ELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQER---CNLEKELAKNK 503
E+ I ++ E+ + ++EK+ + + + ++ +E NL K K +
Sbjct: 974 VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQE 1033
Query: 504 VDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGK 563
V I+ L L+ E+ + L + A +L T+D + +I E K +LA
Sbjct: 1034 VMISDLEERLKKEEKTRQEL--EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK---- 1087
Query: 564 LQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEV 623
K ++L+ + D +L ++ K+ + LQ + A+ + +++ +A+ +++
Sbjct: 1088 ---KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL 1144
Query: 624 KSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKV 683
LE K EL T+ A + K ++++ ++ ++ N + Q+ + ++ +
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204
Query: 684 TIMLENVLASHSKMQGALEKVQIELGRRDSEIA----GLKKERDLNQQRVQKLEAEVDQW 739
L L + + LEK + L + E+A L++ + ++ + +KL+A+V +
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264
Query: 740 QARMLVMEDQHNSEIESLQKALGVARE-DNRKLAMSLEQA-------LQTNNHLQTKLDH 791
A+ + + +E +KA + E DN ++ LE+A + L+++L
Sbjct: 1265 HAK---VSEGDRLRVELAEKASKLQNELDN--VSTLLEEAEKKGIKFAKDAASLESQLQD 1319
Query: 792 IQEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRKQ-------FQTERETTKK 844
QE L+ + ++ NL + + R EE K + E E RK Q++ TKK
Sbjct: 1320 TQELLQEETRQKLNLSS-RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK 1378
Query: 845 VAQREVAELKKALDEANFRSV-EVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHL 903
++ + ++L+EA + + + ++ L +K +K LE K +++ + + + L
Sbjct: 1379 KVDDDLGTI-ESLEEAKKKLLKDAEALSQRLEEKALAYDK-LEKTKNRLQQELDDLTVDL 1436
Query: 904 SAKANNAQNIE-RMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLA 962
+ A N+E + K+ ++ L + + I +Y ++ + + +L + ++
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL 1496
Query: 963 KSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESE 1022
+++ + +NKQ +E +L + ++ + V L+K K A E ++E + E
Sbjct: 1497 EAKEEFERQNKQLRADME-------DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549
Query: 1023 QITANLEEAHRWFKHRFDGLQLELTKNRLQR--PSGEDRWQEKDQDVKHDVMSNQSVLHR 1080
++ L +A K R + + ++ K + +R + +++ +EK + + V ++ L
Sbjct: 1550 ELEDEL-QATEDAKLRLE-VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 1081 WERKQNLRPMPKKYHSEVQRK 1101
ERKQ + K E+ K
Sbjct: 1608 -ERKQRALAVASKKKMEIDLK 1627
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 146 bits (369), Expect = 9e-35
Identities = 215/996 (21%), Positives = 426/996 (42%), Gaps = 125/996 (12%)
Query: 115 KMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKA 174
K NI +KDL+ Q+ L+ RL+A + L +H+E+ + + +KEE +
Sbjct: 332 KKNIQATLHQKDLDCQQ---LQSRLSASETS----LHRIHVELSEKGEATQKLKEELSEV 384
Query: 175 QDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQ-EKYLRESLEKS 233
+ + Q L A K Q ++ +L++ +++ K+ E RQL + L+E + S
Sbjct: 385 ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLS 444
Query: 234 ASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEE-------L 286
+ ++ K Q++ +++ K + +Q L++ + ++ EL Q K K++
Sbjct: 445 SEKLMDKEQQV---ADLQLKLSRLEEQ----LKEKVTNSTELQHQLDKTKQQHQEQQALQ 497
Query: 287 EIATSQLKSDLTSRDDLISKLVEENKNLQ------------ISFNKEHEENAYLR----- 329
+ T++L+ + ++ ++ ++++ +Q IS ++ E+ Y +
Sbjct: 498 QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGE 557
Query: 330 SEIMSLHEASEKAQVLNDQLTKKCSELSCMLQT-----------VTMEKARIIADHQAIL 378
E L++ EK L +Q+T+ +L ++ V +KA + A +L
Sbjct: 558 GETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVL 617
Query: 379 QVEQKMMTQTFQ-----EQNLLLDAAHASITNELQTVQNEKTQLQAHL-DHLILEHNQCI 432
+E + Q E+ LD + T L + + KT +A L +HL N
Sbjct: 618 SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQ 677
Query: 433 QKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQER 492
K Q+ K T L+ A+L+ + E Q + L E KE++ KTE E+ +
Sbjct: 678 DKQQELNKITT----QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE-ELEGQI 732
Query: 493 CNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQ-----QVTSDYHGLAQQKV 547
LE + + K +LQ + N L + L Q ++ S Q+K
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792
Query: 548 EKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELS 607
E + K KL + + QI + E Q +T +Q++ L + T+ + E
Sbjct: 793 EALESIKQKLTKQEEEKQILKQDFETLSQ---ETKIQHEELNNRIQTTVTELQKVKMEKE 849
Query: 608 AKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAAL----KESQKLKEDLEAVEDREN 663
A L L +V L+ SK E + + AA+ K ++LK L+ +
Sbjct: 850 ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 664 KKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERD 723
K+ ++ L + KE + ++ + L ++ + Q L++ + E + I LK+ +
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969
Query: 724 LNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNN 783
+++++ L+ E+ + +E++ ++ + L +E L + E++ +T
Sbjct: 970 QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFK 1029
Query: 784 HLQT---------------------KLDHIQEQLES--KELERQN-----LETFKDRMTE 815
LQ+ KL QE L S ++ QN L+T K + +
Sbjct: 1030 QLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ 1089
Query: 816 ESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELR 875
+S + + ER +AL + Q E+ +K E ++L + + + E+++ N EL+
Sbjct: 1090 DSAKKEQQLQERCKAL-QDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELK 1148
Query: 876 -QKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQ 934
KL +++I +N + K Q KL L KA++ + +E+E + +++KDQ +
Sbjct: 1149 SHKLESIKEI--TNLKDAKQLLIQQKLELQGKADSLK-----AAVEQEKRNQQILKDQVK 1201
Query: 935 KKNYEQSLSIQRFVCEMTNL-----QKEMQMLAKSQYDASVRNKQQEL--HLEAERKIRQ 987
K+ E + F+ + L +KE+ M + +A + + L +L +K Q
Sbjct: 1202 KEEEELK---KEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQ 1258
Query: 988 ELENRCQELEETVRHLKKCKEATENTLKEASVESEQ 1023
+ R ELE+ L+ E + EA+V++ Q
Sbjct: 1259 SSQRRVSELEKQTDDLR-----GEIAVLEATVQNNQ 1289
Score = 142 bits (359), Expect = 1e-33
Identities = 175/814 (21%), Positives = 357/814 (43%), Gaps = 78/814 (9%)
Query: 265 LRDSIQSAQELLAQEQKKKEELEIATSQ---LKSDLTSRDDLISKLVEENKNLQISFNKE 321
LR +Q Q L +E+ EEL+ + L+ D L++ E ++L+ +
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147
Query: 322 HEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVE 381
EN ++ + + + + +E++ + E++ A Q + ++
Sbjct: 148 QTENFNIK----------QMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLT 197
Query: 382 QKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKR 441
+++ + Q+L + ++ ++ E Q+Q +D++ LE + +K +D K+
Sbjct: 198 EELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK 257
Query: 442 TAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELAK 501
Q E+TI++LR EL QE ++E ++ + VN E+ Q+ L + L K
Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVN----ELTQKNQTLTENLLK 313
Query: 502 NKVDINTL--THNLQTLEEENKHLADQMASLELQQVTS-------DYHGLAQQKVEKITE 552
+ D L HN +++ ++N L+ QQ+ S H + + EK E
Sbjct: 314 KEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK-GE 372
Query: 553 SKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVH 612
+ KL E +++ K + L+ + F Q + + LQ++ Q +S+L
Sbjct: 373 ATQKLKEELSEVETKYQHLKAE---FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429
Query: 613 LQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQ--KLKEDLEAVEDRENKKVGN-- 668
L +A LKE + + S E+L KE Q L+ L +E++ +KV N
Sbjct: 430 LGEAHGRLKEQRQL---SSEKLMD---------KEQQVADLQLKLSRLEEQLKEKVTNST 477
Query: 669 -FQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQ 727
Q QL + K+ + + + ++ A + Q LE+V ++G +D +I L+ +++
Sbjct: 478 ELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKE 537
Query: 728 RVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQT 787
+ LE E + A++ E + + + LQ+ +E +L L+ +++ Q
Sbjct: 538 NISLLEKEREDLYAKIQAGEGE-TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE 596
Query: 788 KL-DHIQEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVA 846
L D +QEQ + +L +DR+ EL+++ E+ K Q + + K
Sbjct: 597 NLHDQVQEQ-------KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 649
Query: 847 QREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKI---LESNKEKIKNQK---TQIK 900
AE K A+ ++ + L+ K EL KI L+ K+++++ +Q++
Sbjct: 650 LLLSAEAAKTAQRADLQN-HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLE 708
Query: 901 LHLSAKANNAQNIE-RMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQ 959
HL ++E + +++E ++K++E + K + EQ+L +LQ++ Q
Sbjct: 709 SHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV-KASKEQALQ---------DLQQQRQ 758
Query: 960 MLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASV 1019
+ + A+ +KQ E+ E R +L+ + + LE + L K +E + LK+
Sbjct: 759 LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTK-QEEEKQILKQ--- 814
Query: 1020 ESEQITANLEEAHRWFKHRFDGLQLELTKNRLQR 1053
+ E ++ + H +R EL K ++++
Sbjct: 815 DFETLSQETKIQHEELNNRIQTTVTELQKVKMEK 848
Score = 131 bits (329), Expect = 4e-30
Identities = 188/954 (19%), Positives = 426/954 (44%), Gaps = 105/954 (11%)
Query: 108 ESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAV 167
E + L++ + RL+ + + L+ +L+ +++H + L LR+ +
Sbjct: 452 EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL 511
Query: 168 KEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLR 227
++ + D+ Q++ + ++K+N +++E+E + + KIQ + A L+
Sbjct: 512 EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE----REDLYAKIQAGEGETAVLNQLQ 567
Query: 228 E---SLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKE 284
E +L++ + + K++ + + ++ +H D +Q + L Q +
Sbjct: 568 EKNHTLQEQVTQLTEKLKNQSESHKQAQENLH----------DQVQEQKAHLRAAQDRVL 617
Query: 285 ELEIATSQLKSDLTSRDDLISKL---VEENKNLQISFN-KEHEENAYLRSEIMSLHEASE 340
LE + ++L S L + +S+L ++ L +S + + A L++ + + A +
Sbjct: 618 SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQ 677
Query: 341 KAQVLNDQLTKKCSELSCMLQTVTMEKARIIADH-----QAILQVEQKMMTQTFQEQNLL 395
Q +++T + +++ LQ E + H + L +EQK Q + L
Sbjct: 678 DKQQELNKITTQLDQVTAKLQD-KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE 736
Query: 396 LDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIAR 455
D+ + E Q +Q+ + Q Q + D LE +A + K+ ++KE++ ST
Sbjct: 737 ADSLEVKASKE-QALQDLQQQRQLNTD---LE-----LRATELSKQLEMEKEIVSSTRLD 787
Query: 456 LRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQT 515
L+ + EA K+ L +++E ++++ K + E + + ++ E N+ I T LQ
Sbjct: 788 LQKKSEALESIKQKLTKQEE--EKQILKQDFETLSQETKIQHEELNNR--IQTTVTELQK 843
Query: 516 LEEENKHLADQMASL--ELQQVTSDYHGLAQQKVEKITESKNKLAYENGK-------LQI 566
++ E + L +++++ +L +V+ + + SK++ EN K L+
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVS-----------DSLKNSKSEFEKENQKGKAAILDLEK 892
Query: 567 KVKQLEEQVQ-SFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKS 625
K+L+ Q+Q +T + L+K + + Q EL++ + L QA LK+ +
Sbjct: 893 TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
Query: 626 ILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTI 685
++ + ++ + K+ + L+ +L+ ++ + Q+QL +A ++
Sbjct: 953 EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012
Query: 686 MLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLV 745
+ + ++ K Q +++Q + R+SE+ L +DL + A+ D R +
Sbjct: 1013 KISVLQNNYEKSQETFKQLQSDFYGRESEL--LATRQDLKSVEEKLSLAQEDLISNRNQI 1070
Query: 746 MEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQN 805
N I+ L+ A +D+ K L++ + +Q + +++L +++ +
Sbjct: 1071 --GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAE 1128
Query: 806 LETFKDRMTEE-SKVEAELHAERIEALRKQFQTERETTKKVAQREV-----AELKKALDE 859
+E K R +E +K+ EL + ++E++ K+ ++ + + Q+++ A+ KA E
Sbjct: 1129 IEEIKCRQEKEITKLNEELKSHKLESI-KEITNLKDAKQLLIQQKLELQGKADSLKAAVE 1187
Query: 860 ANFRSV-----EVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIE 914
R+ +V + EL+++ E E L S +IK ++ +K H +A I
Sbjct: 1188 QEKRNQQILKDQVKKEEEELKKEFIEKEAKLHS---EIKEKEVGMKKHEENEAKLTMQIT 1244
Query: 915 RMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEM----TNLQKEMQMLAKSQYDASV 970
+ + + +K ++Q S QR V E+ +L+ E+ +L +A+V
Sbjct: 1245 ALNE------NLGTVKKEWQ--------SSQRRVSELEKQTDDLRGEIAVL-----EATV 1285
Query: 971 RNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQI 1024
+N Q E ER ++ E E ++L+ V L++ + T ++E E++ +
Sbjct: 1286 QNNQDERRALLERCLKGEGE--IEKLQTKVLELQRKLDNTTAAVQELGRENQSL 1337
Score = 93.2 bits (230), Expect = 1e-18
Identities = 134/589 (22%), Positives = 252/589 (42%), Gaps = 64/589 (10%)
Query: 98 EFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEV 157
E L NR+ + +Q +KM L TE K + + D L + E K+ + +
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 158 MNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELR 217
++L + + +K Q +VQ + TLK + KK+ E+ K ++ L++ ++
Sbjct: 888 LDLEKTCKELKH-----QLQVQ-MENTLKEQKELKKSL----EKEKEASHQLKLELNSMQ 937
Query: 218 RQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLA 277
QL Q + + EK + I E+ + E ++KQ+ LQ L+ ++ EL
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE---LKIAVLQKTEL-- 992
Query: 278 QEQKKKEELEIATSQL---KSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMS 334
E K +++L A +L K ++ + K E K LQ F E R ++ S
Sbjct: 993 -ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS 1051
Query: 335 LHE---------ASEKAQVLN-DQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKM 384
+ E S + Q+ N ++L ++ L+ + +K + + + LQ QK
Sbjct: 1052 VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQK- 1110
Query: 385 MTQTFQEQNLLLDAAHASITNELQTVQ-NEKTQLQAHLDHLILEHNQCIQKAQDAEKRTA 443
++ +E+ L+ + + + E++ Q E T+L L LE + I +DA++
Sbjct: 1111 -EKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLI 1169
Query: 444 VQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKEL---- 499
QK L+ L+ +E QEK++ K++ ++E + +KE +++ L E+
Sbjct: 1170 QQKLELQGKADSLKAAVE---QEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226
Query: 500 ----------AKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHG---LAQQK 546
AK + I L NL T+++E + + Q EL++ T D G + +
Sbjct: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEWQ--SSQRRVSELEKQTDDLRGEIAVLEAT 1284
Query: 547 VEKITESKNKLAY-------ENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKY 599
V+ + + L E KLQ KV +L+ ++ +T+ L + N+ LQ K+
Sbjct: 1285 VQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLD---NTTAAVQELGRENQSLQIKH 1341
Query: 600 AQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKES 648
QA + A+ +Q A K + R + C + K +
Sbjct: 1342 TQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNA 1390
Score = 64.3 bits (155), Expect = 6e-10
Identities = 118/552 (21%), Positives = 228/552 (41%), Gaps = 99/552 (17%)
Query: 596 QTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALK--------- 646
++ A +++ R +Q A LKE K E K+EL + + K
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 647 -ESQKLKEDLE-----------------------AVEDRENKKVGNFQRQLAEAKEDNCK 682
E Q L++ LE A E + K + +R L EA E K
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQ--K 192
Query: 683 VTIMLENVLASHSKMQGALEKVQIELGRRD--SEIAGLKKE----------RDLNQQR-V 729
VT + E + +K ++ ++ EL +R ++A LKKE L ++R
Sbjct: 193 VTRLTEEL----NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 730 QKLEAEVDQWQARMLVME---DQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHL- 785
+KL+ E + Q++ E Q SE+ + + V ++ +KL S+ + Q N L
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT 308
Query: 786 ---------QTKLD-----------HIQEQLESKELERQNLET-FKDRMTEESKVEAELH 824
TKL+ +IQ L K+L+ Q L++ T ++ EL
Sbjct: 309 ENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL- 367
Query: 825 AERIEALR--KQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELE 882
+E+ EA + K+ +E ET + + E +L++ +E +++ +L KL E E
Sbjct: 368 SEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 883 KILESNKEKIKNQKTQIKLHLSAKANNAQNIE-RMKQIEKELK-------QMELIKDQYQ 934
+ L ++K Q+ L K +++ ++ ++E++LK +++ D+ +
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487
Query: 935 KKNYEQSLSIQRFVCEMTNLQKEMQMLAK--SQYDASVRNKQQELHLEAE-----RKIRQ 987
+++ EQ Q ++ Q +++ + + D ++N + L E K R+
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
Query: 988 ELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFDGLQLELT 1047
+L + Q E L + +E +TL+E + + N E+H K + L ++
Sbjct: 548 DLYAKIQAGEGETAVLNQLQE-KNHTLQEQVTQLTEKLKNQSESH---KQAQENLHDQVQ 603
Query: 1048 KNRLQRPSGEDR 1059
+ + + +DR
Sbjct: 604 EQKAHLRAAQDR 615
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 146 bits (369), Expect = 9e-35
Identities = 242/1122 (21%), Positives = 466/1122 (41%), Gaps = 179/1122 (15%)
Query: 26 SETFTVLQQRMRIVEEQTSSLRDDLIMLDFG-EKRGYLEAPDCLEDLDSQKVISPIQNEA 84
SET +++ R+ E+Q + R+ L ++ EK+ L +++ +Q
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 85 ICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQE 144
+ + + E V+ + S+ + L+ R +E ++ + A Q
Sbjct: 1398 -----QEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAK----------ARQA 1440
Query: 145 EHSKDLKL-LHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELK 203
E ++ +L + E+ +R QL A + + A+ E+Q L A + A K+ A E L+
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 204 T-----TKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
++RK +++ R A+ + RE + L++Q + + + +V
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
+Q +AL + +SA+ A+ Q K+ T+QL+ L +++L EE
Sbjct: 1561 RQVQVALETAQRSAE---AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA------- 1610
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E A ++E E +E+ L K L LQ + + + +A +A
Sbjct: 1611 ----ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDA 438
Q E+ E + + K + QA + E Q ++K +
Sbjct: 1665 QKEEA----------------------EREARRRGKAEEQAVRQRELAE--QELEKQRQL 1700
Query: 439 EKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKE 498
+ TA Q+ E + RLR E E Q+++ L EE R QRE Q+R LE E
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA----TQKRQELEAE 1756
Query: 499 LAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQ--KVEKITES--- 553
LAK + ++ L + EEE++ +++ + L+ + LA++ ++ + E
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEK-SKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815
Query: 554 KNKLAYENGKLQI---------KVKQLEEQVQSFTDTSL-------QNDHLRKM------ 591
+ +LA E+ Q K+ + E + T+ + +N+ LR++
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 592 -NKYLQTKYAQANSELSAKRVHLQQA-DAHLKEVKSILE---RSKEELSRTVKCRNAALK 646
+ L+ + AQ +++ + L++A D+ L+ K ++E R + ++ + A+ +
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 647 ESQKLKEDLE---------AVEDRENKKVGNF----QRQLAEAKE-------DNCKVTIM 686
++ K +LE A + +K+ QRQLA +E + + ++
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 687 LENVLASHSKMQGALEKVQ-----IELGRRDSEIAGLKKERDLN------QQR------- 728
E A K ALE+V+ +E RR E A + R L Q+R
Sbjct: 1996 AEEEAARQRK--AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 729 ----VQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE-----------------D 767
VQ+ E E+ Q + + DQ E E+ ++A A E +
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 768 NRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAER 827
+L S E+ Q Q + ++++ E + R E R + + E E H +
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2173
Query: 828 IE-ALRKQFQTERE-TTKKVAQREVAELKKALDEANFR----SVEVSRTNRELRQKLAEL 881
E LR++ Q E+E TT ++ E K LDE R + E +R ++ ++L +
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 882 EKILES-NKEKIKNQKTQIKLHLSAKANNA----QNIERMKQIEKELKQMELIKDQYQKK 936
+E +K K + + L L K N + E+MKQ+ +E ++ + + +
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 937 NY--EQSLSIQRFVCEMTNLQKEMQMLAKS---QYDASVRNKQQELHLEAERKIRQELEN 991
E+ L+ QR + E L+++MQ + ++ + +A + +Q+EL E R+++++ E
Sbjct: 2294 RQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 992 RCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHR 1033
Q+L E + ++ EA E S E+E++ + E R
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394
Score = 141 bits (355), Expect = 4e-33
Identities = 214/985 (21%), Positives = 421/985 (42%), Gaps = 112/985 (11%)
Query: 138 RLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAI 197
RL A E+ + +LL E+ L+++ A ++ + + E+ ++ A +++ +K A
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-- 1774
Query: 198 IEEELKTT--KRKMNLKIQELR-RQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQ 254
EEE ++T K K L+ + R R+LA+E +L + A +E + E ++
Sbjct: 1775 -EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1833
Query: 255 VHILQQNCIALRDSIQSAQELLAQEQKKKEE---------------LEIATSQLKSDLTS 299
V + I +++ E+ +E++ + E LE +Q K+D+
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893
Query: 300 RDDLISKLVEENKNLQISFNKEH-EENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSC 358
R + K + Q ++ + + EI++L + EKA +L + +
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 359 MLQTV--TMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQ 416
+ + E+A + A Q L E++ + +E+ AA + + E +
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 417 LQAHLDHLIL-------EHNQCIQKAQDA-EKRTAVQKELLESTIARLRGELEASMQEKK 468
L+A ++ E + +Q AQ+A +KR +++ + + EL+ ++Q+++
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 469 SLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMA 528
S+L++ + +E + R E+E A+++ + Q+ EE+ + A A
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 529 SLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHL 588
+ E K+ K E + + + ++ KQ D ++ H
Sbjct: 2134 AAE--------------KLRKEAEQEAARRAQAEQAALRQKQA-------ADAEMEK-HK 2171
Query: 589 RKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKES 648
+ + L+ K AQ EL+ R+ L++ D + L+R K E + + R+ +E
Sbjct: 2172 KFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230
Query: 649 QKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIEL 708
++ +E + + ++ R L +DN + + E + Q A E ++ +
Sbjct: 2231 FSVRVQMEELS-KLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVAEEAARLSV 2285
Query: 709 GRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQH-NSEIESLQKALGVARED 767
+++ E DL QQR + ++ QA V E +E E LQ+ +A+E
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA---VQEATRLKAEAELLQQQKELAQEQ 2342
Query: 768 NRKLAMSLEQALQ-----TNNHLQTKLDHIQEQLE-SKELERQNLETFK-DRMTEESKVE 820
R+L EQ Q T +T Q QLE S E ER L + R ++ +
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2402
Query: 821 AELHAERIEAL-RKQFQTERETTKKVAQREVAELKKALDEANFRSVE--VSRTNRELRQK 877
A+ ++ E + K +TE T +KV + E+++ + + + ++ RE ++K
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEK 2461
Query: 878 LAELEKILESNKEKIKN-------QKTQIKLHLSAKANNAQNIERMKQIEKELKQME-LI 929
L + K+L+ E+++ Q+TQ L S + ++R + IE+E ++E L
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 930 KDQYQKKNY---EQSLSIQRFVCEMTNLQKEMQMLAKSQYDAS--VRNKQQELH-LEAER 983
+D+ K EQ Q+ E L M+ + Q++A VR KQ+EL LE +R
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWF-------- 1035
+ ++EL L E + L++ + E + A SE++TA+ A +
Sbjct: 2581 RQQEEL------LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2634
Query: 1036 --------KHRFDGLQLELTKNRLQ 1052
+H FDGL+ +++ RLQ
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQ 2659
Score = 132 bits (332), Expect = 2e-30
Identities = 217/1042 (20%), Positives = 433/1042 (41%), Gaps = 138/1042 (13%)
Query: 162 QQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMN--LKIQELRRQ 219
+++ A+ E A L TL Q + +AI E+LKT + +E+ R
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR- 1106
Query: 220 LAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQE 279
A E+ L+E+ ++ A L +++ ++++ R Q Q ALRD ++ AQE+ +
Sbjct: 1107 -AHEEQLKEA--QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1163
Query: 280 QKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEAS 339
Q++ E ++ + + + + ++ + Q + + Y R L
Sbjct: 1164 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1223
Query: 340 EKAQVLNDQL-TKKCSELSCMLQTVTMEKARI--IADH---------------QAILQVE 381
+ A+ +Q+ ++ + + + E+A + I H AI E
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283
Query: 382 QKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKR 441
+++T Q + + A + + ++V E L+ H L +Q I+ + +R
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1343
Query: 442 TAVQKELLESTIARLR---GELEASMQEKKSLLEE---------------KERFQREVNK 483
++ L E A R E+EA++++++ L E ++R Q EV +
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 484 TEKEIV---QERCNLEKELAK----NKVDINTLTHNLQTLEEENKHLADQMASLELQ-QV 535
E+ V Q++ ++++EL + ++ +I + E + +++ + LQ +
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463
Query: 536 TSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN---------- 585
T G A+ +++ + + + + Q + ++L QVQ + Q
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523
Query: 586 ---------------DHLRKMNKYLQTKYAQANSELS------------AKRVHLQQADA 618
+ LR + + + QA E + + LQ A
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 619 HLKEVKSILERS-KEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAK 677
E + LERS +EE + R A + +Q+ E A E+ E +++ +Q + EA
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEA- 1641
Query: 678 EDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVD 737
++ + E V S Q EK Q E R++ G +E+ + Q+ + + E E
Sbjct: 1642 ---LRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 738 QW------QARMLVMED--QHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKL 789
+ Q R+ ++ + +E E ++ + E+ +L A Q L+ +L
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757
Query: 790 DHIQEQLE--------SKELERQNLETFKDRMTEESKVEAEL--HAERIEALRKQFQTER 839
++ ++E ++E R E K R+ E+ EL A R+ AL ++ + +R
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 840 ETTKKVAQREVAELKKALDEANFRSVEVSRTNRE----LRQKLAELEKILESNKEKIKNQ 895
+ ++ A R+ AE ++ L E E +R E L++K AE E++ +++ +
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877
Query: 896 KTQIKLHLSAKANNAQNIERMKQIEK----EL-KQMELIKDQY-QKKNYEQSL-----SI 944
+ +L A + A ER+ Q+ K EL +Q L++D Q++ E+ + S
Sbjct: 1878 R---RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 945 QRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLK 1004
++ L+ E+ + + D +Q EL +R++ E E R +E EE V+
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994
Query: 1005 KCKEATENTLKEASVESEQITANLEEAHRWFK--HRFDGLQLELTKNRLQ-RPSGEDR-- 1059
+E K A E E++ A +EEA R + + QL+L + Q R E++
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054
Query: 1060 ---WQEKDQDVKHDVMSNQSVL 1078
Q+K+Q+++ + QSVL
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVL 2076
Score = 61.2 bits (147), Expect = 5e-09
Identities = 73/337 (21%), Positives = 145/337 (43%), Gaps = 42/337 (12%)
Query: 107 LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRA 166
L+ MQ+++ RL+ E +L Q+ +++ +QE+ + + L E ++ L A
Sbjct: 2312 LKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 167 VKEEEDKAQDEVQRLTATL-----------KIASQTKKNAAIIEEELKTTKRKMNLKI-- 213
++ + + E +RL + + A + +K A I E+L T+ K+
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 214 ---------------QELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVER--KQVH 256
+ LR +A+ + +E L++ A + LK +EM TV+ E+ ++
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQ 2489
Query: 257 ILQQNCIALRDSIQSAQELLAQEQKKKEEL---EIATSQLKSDLTSRDDLISKLVEENKN 313
LQQ+ ++ +DS+ + + QE+ K E+L E+A +Q + R ++ +E +
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ--QQMEQERQR 2547
Query: 314 LQISF----NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKAR 369
L S ++HE +R + L + ++ + + L ++ L LQ + E+ R
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHR 2606
Query: 370 IIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNE 406
H + Q T+T LD A E
Sbjct: 2607 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 57.4 bits (137), Expect = 7e-08
Identities = 86/464 (18%), Positives = 178/464 (38%), Gaps = 43/464 (9%)
Query: 23 ATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQN 82
A + T L+ ++ + Q + L ++L L + E+L S +V Q
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV----QM 2237
Query: 83 EAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAI 142
E + K I +N +L+ K N R E+ ++ A RL+
Sbjct: 2238 EELSKLKARIEAEN-----------RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 143 QEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEEL 202
+E ++ +L ++ R + +E+ +A E RL A ++ Q K+ A L
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2346
Query: 203 KTTKRKMNLKIQE----LRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
+ K +M ++ E +R L E+ + + A + L++ EM +
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
++ + + + + ++ + LEI Q D + I++L E + LQ
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ--- 2463
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E L SE+ Q + + + E + Q+ EK ++ + +
Sbjct: 2464 -----------QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEKDSLL-QRERFI 2509
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQ----- 433
+ E+ + Q FQ++ + Q ++ E+ +L A ++ ++ +
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 434 --KAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKE 475
+ Q E++ Q+ELL RLR +L+ ++ ++ L E
Sbjct: 2570 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2613
Score = 47.8 bits (112), Expect = 6e-05
Identities = 208/1085 (19%), Positives = 422/1085 (38%), Gaps = 186/1085 (17%)
Query: 166 AVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEK- 224
A+ E E + + E +RL +I ++ + A + EE+L + ++ L ++
Sbjct: 376 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA 435
Query: 225 -YLRESLEKSASAMLLKIQEMGSTVEVERKQ-------VHILQQNCIALR---------- 266
+ L+K+ S + L ++ + + Q V+ L + +A+R
Sbjct: 436 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG 495
Query: 267 ---DSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHE 323
+ Q AQ L Q +++ ELE +T + DL + VEEN++ ++ +
Sbjct: 496 VAAPATQVAQVTL-QSVQRRPELEDSTLRYLQDLLA-------WVEENQH-RVDGAEWGV 546
Query: 324 ENAYLRSEIMS---LHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQV 380
+ + +++ S LH++ E+ + ++ +LS + D L +
Sbjct: 547 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA-------YRDCLGRLDL 599
Query: 381 EQKMMTQTFQEQNLLLDAAH---ASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQD 437
+ + + + + L++ H A+ T EL + NEK + + D N +K
Sbjct: 600 QYAKLLNSSKARLRSLESLHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKK--- 655
Query: 438 AEKRTAVQK--ELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNL 495
E +A+ + EL E I L+ + ++E E FQ + ++Q C +
Sbjct: 656 -ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCI 714
Query: 496 EKELAKNKV------DINTLTHNLQTLEE--ENKHLADQMASL-ELQQVTSDYHGLAQQK 546
E L +N D+ LQ L+E K+ D+ A++ L+ + D AQ +
Sbjct: 715 EAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQD----AQDE 770
Query: 547 VEKITESKNKLA----YENGKLQIK-------------------VKQLEEQVQSFTDTSL 583
E++ E K L+ +Q+K KQ+E V + L
Sbjct: 771 KEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL 830
Query: 584 QNDHLRKMNKYLQTKYAQA------------NSELSAKRVHLQQADAHL--------KEV 623
K L + ++A N E L+ L ++
Sbjct: 831 VGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 890
Query: 624 KSILE----RSKEELSRTVKCRNAALKESQKLKEDLEAVE------DRENKKVGNF---Q 670
KS+L R +L R+ + ++ ++ L ++E R+++ G F
Sbjct: 891 KSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPED 950
Query: 671 RQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQR-V 729
R +AE + +C + + +L S QGA E+ + + R SE+ ++ + + + R V
Sbjct: 951 RLMAEREYGSC--SHHYQQLL--QSLEQGAQEESRCQ--RCISELKDIRLQLEACETRTV 1004
Query: 730 QKLEAEVDQWQAR----MLVMEDQHNSEIESLQKALGVAR---EDNRKLAM--------- 773
+L +D+ AR + + + +E+E L K GVAR E + LA+
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK--GVARLSAEAEKVLALPEPSPAAPT 1062
Query: 774 ----------SLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEA-- 821
LEQ + KL I + + + L ++++ E V A
Sbjct: 1063 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1122
Query: 822 -ELHAER--IEALRKQFQTERETTKKVAQ--REVAELKKALDEAN-FRSVEVSRTNRELR 875
EL A + ++ LR Q + ++ T + R E+ + L + + R VEV R +
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 876 QKLAELEKIL---ESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQ 932
Q L + +L + + +++ Q++ + + ++ ++ +++++ M L Q
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 933 YQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQEL-----HLE------A 981
++ Q ++ + +E Q AK QY ++++ + +L LE
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAK-QYINAIKDYELQLVTYKAQLEPVASPAK 1301
Query: 982 ERKIRQELENRCQELEETVRHLKKCKEATENTLKEAS-----VESEQITANLEEAHRWFK 1036
+ K++ E+ QE + H + T +K S +E E+ A + A +
Sbjct: 1302 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--R 1359
Query: 1037 HRFDGLQLELTKNR-LQRPSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQNLRPMPKKYH 1095
R ++ L K R L + + Q + + + + V+ R E + + +
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 1096 SEVQR 1100
E+Q+
Sbjct: 1420 EELQQ 1424
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 146 bits (369), Expect = 9e-35
Identities = 242/1122 (21%), Positives = 466/1122 (41%), Gaps = 179/1122 (15%)
Query: 26 SETFTVLQQRMRIVEEQTSSLRDDLIMLDFG-EKRGYLEAPDCLEDLDSQKVISPIQNEA 84
SET +++ R+ E+Q + R+ L ++ EK+ L +++ +Q
Sbjct: 1342 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1401
Query: 85 ICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQE 144
+ + + E V+ + S+ + L+ R +E ++ + A Q
Sbjct: 1402 -----QEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAK----------ARQA 1444
Query: 145 EHSKDLKL-LHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELK 203
E ++ +L + E+ +R QL A + + A+ E+Q L A + A K+ A E L+
Sbjct: 1445 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1504
Query: 204 T-----TKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
++RK +++ R A+ + RE + L++Q + + + +V
Sbjct: 1505 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1564
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
+Q +AL + +SA+ A+ Q K+ T+QL+ L +++L EE
Sbjct: 1565 RQVQVALETAQRSAE---AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA------- 1614
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E A ++E E +E+ L K L LQ + + + +A +A
Sbjct: 1615 ----ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1668
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDA 438
Q E+ E + + K + QA + E Q ++K +
Sbjct: 1669 QKEEA----------------------EREARRRGKAEEQAVRQRELAE--QELEKQRQL 1704
Query: 439 EKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKE 498
+ TA Q+ E + RLR E E Q+++ L EE R QRE Q+R LE E
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA----TQKRQELEAE 1760
Query: 499 LAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQ--KVEKITES--- 553
LAK + ++ L + EEE++ +++ + L+ + LA++ ++ + E
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEK-SKQRLEAEAGRFRELAEEAARLRALAEEAKR 1819
Query: 554 KNKLAYENGKLQI---------KVKQLEEQVQSFTDTSL-------QNDHLRKM------ 591
+ +LA E+ Q K+ + E + T+ + +N+ LR++
Sbjct: 1820 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879
Query: 592 -NKYLQTKYAQANSELSAKRVHLQQA-DAHLKEVKSILE---RSKEELSRTVKCRNAALK 646
+ L+ + AQ +++ + L++A D+ L+ K ++E R + ++ + A+ +
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939
Query: 647 ESQKLKEDLE---------AVEDRENKKVGNF----QRQLAEAKE-------DNCKVTIM 686
++ K +LE A + +K+ QRQLA +E + + ++
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999
Query: 687 LENVLASHSKMQGALEKVQ-----IELGRRDSEIAGLKKERDLN------QQR------- 728
E A K ALE+V+ +E RR E A + R L Q+R
Sbjct: 2000 AEEEAARQRK--AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2057
Query: 729 ----VQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE-----------------D 767
VQ+ E E+ Q + + DQ E E+ ++A A E +
Sbjct: 2058 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2117
Query: 768 NRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAER 827
+L S E+ Q Q + ++++ E + R E R + + E E H +
Sbjct: 2118 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2177
Query: 828 IE-ALRKQFQTERE-TTKKVAQREVAELKKALDEANFR----SVEVSRTNRELRQKLAEL 881
E LR++ Q E+E TT ++ E K LDE R + E +R ++ ++L +
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2237
Query: 882 EKILES-NKEKIKNQKTQIKLHLSAKANNA----QNIERMKQIEKELKQMELIKDQYQKK 936
+E +K K + + L L K N + E+MKQ+ +E ++ + + +
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297
Query: 937 NY--EQSLSIQRFVCEMTNLQKEMQMLAKS---QYDASVRNKQQELHLEAERKIRQELEN 991
E+ L+ QR + E L+++MQ + ++ + +A + +Q+EL E R+++++ E
Sbjct: 2298 RQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Query: 992 RCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHR 1033
Q+L E + ++ EA E S E+E++ + E R
Sbjct: 2357 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2398
Score = 141 bits (355), Expect = 4e-33
Identities = 214/985 (21%), Positives = 421/985 (42%), Gaps = 112/985 (11%)
Query: 138 RLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAI 197
RL A E+ + +LL E+ L+++ A ++ + + E+ ++ A +++ +K A
Sbjct: 1721 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-- 1778
Query: 198 IEEELKTT--KRKMNLKIQELR-RQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQ 254
EEE ++T K K L+ + R R+LA+E +L + A +E + E ++
Sbjct: 1779 -EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1837
Query: 255 VHILQQNCIALRDSIQSAQELLAQEQKKKEE---------------LEIATSQLKSDLTS 299
V + I +++ E+ +E++ + E LE +Q K+D+
Sbjct: 1838 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1897
Query: 300 RDDLISKLVEENKNLQISFNKEH-EENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSC 358
R + K + Q ++ + + EI++L + EKA +L + +
Sbjct: 1898 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1957
Query: 359 MLQTV--TMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQ 416
+ + E+A + A Q L E++ + +E+ AA + + E +
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Query: 417 LQAHLDHLIL-------EHNQCIQKAQDA-EKRTAVQKELLESTIARLRGELEASMQEKK 468
L+A ++ E + +Q AQ+A +KR +++ + + EL+ ++Q+++
Sbjct: 2018 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2077
Query: 469 SLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMA 528
S+L++ + +E + R E+E A+++ + Q+ EE+ + A A
Sbjct: 2078 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2137
Query: 529 SLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHL 588
+ E K+ K E + + + ++ KQ D ++ H
Sbjct: 2138 AAE--------------KLRKEAEQEAARRAQAEQAALRQKQA-------ADAEMEK-HK 2175
Query: 589 RKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKES 648
+ + L+ K AQ EL+ R+ L++ D + L+R K E + + R+ +E
Sbjct: 2176 KFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2234
Query: 649 QKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIEL 708
++ +E + + ++ R L +DN + + E + Q A E ++ +
Sbjct: 2235 FSVRVQMEELS-KLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVAEEAARLSV 2289
Query: 709 GRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQH-NSEIESLQKALGVARED 767
+++ E DL QQR + ++ QA V E +E E LQ+ +A+E
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA---VQEATRLKAEAELLQQQKELAQEQ 2346
Query: 768 NRKLAMSLEQALQ-----TNNHLQTKLDHIQEQLE-SKELERQNLETFK-DRMTEESKVE 820
R+L EQ Q T +T Q QLE S E ER L + R ++ +
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2406
Query: 821 AELHAERIEAL-RKQFQTERETTKKVAQREVAELKKALDEANFRSVE--VSRTNRELRQK 877
A+ ++ E + K +TE T +KV + E+++ + + + ++ RE ++K
Sbjct: 2407 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEK 2465
Query: 878 LAELEKILESNKEKIKN-------QKTQIKLHLSAKANNAQNIERMKQIEKELKQME-LI 929
L + K+L+ E+++ Q+TQ L S + ++R + IE+E ++E L
Sbjct: 2466 LQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2524
Query: 930 KDQYQKKNY---EQSLSIQRFVCEMTNLQKEMQMLAKSQYDAS--VRNKQQELH-LEAER 983
+D+ K EQ Q+ E L M+ + Q++A VR KQ+EL LE +R
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2584
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWF-------- 1035
+ ++EL L E + L++ + E + A SE++TA+ A +
Sbjct: 2585 RQQEEL------LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2638
Query: 1036 --------KHRFDGLQLELTKNRLQ 1052
+H FDGL+ +++ RLQ
Sbjct: 2639 GPAAEAEPEHSFDGLRRKVSAQRLQ 2663
Score = 132 bits (332), Expect = 2e-30
Identities = 217/1042 (20%), Positives = 433/1042 (41%), Gaps = 138/1042 (13%)
Query: 162 QQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMN--LKIQELRRQ 219
+++ A+ E A L TL Q + +AI E+LKT + +E+ R
Sbjct: 1052 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR- 1110
Query: 220 LAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQE 279
A E+ L+E+ ++ A L +++ ++++ R Q Q ALRD ++ AQE+ +
Sbjct: 1111 -AHEEQLKEA--QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1167
Query: 280 QKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEAS 339
Q++ E ++ + + + + ++ + Q + + Y R L
Sbjct: 1168 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1227
Query: 340 EKAQVLNDQL-TKKCSELSCMLQTVTMEKARI--IADH---------------QAILQVE 381
+ A+ +Q+ ++ + + + E+A + I H AI E
Sbjct: 1228 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1287
Query: 382 QKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKR 441
+++T Q + + A + + ++V E L+ H L +Q I+ + +R
Sbjct: 1288 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1347
Query: 442 TAVQKELLESTIARLR---GELEASMQEKKSLLEE---------------KERFQREVNK 483
++ L E A R E+EA++++++ L E ++R Q EV +
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 484 TEKEIV---QERCNLEKELAK----NKVDINTLTHNLQTLEEENKHLADQMASLELQ-QV 535
E+ V Q++ ++++EL + ++ +I + E + +++ + LQ +
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1467
Query: 536 TSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN---------- 585
T G A+ +++ + + + + Q + ++L QVQ + Q
Sbjct: 1468 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1527
Query: 586 ---------------DHLRKMNKYLQTKYAQANSELS------------AKRVHLQQADA 618
+ LR + + + QA E + + LQ A
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1587
Query: 619 HLKEVKSILERS-KEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAK 677
E + LERS +EE + R A + +Q+ E A E+ E +++ +Q + EA
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEA- 1645
Query: 678 EDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVD 737
++ + E V S Q EK Q E R++ G +E+ + Q+ + + E E
Sbjct: 1646 ---LRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701
Query: 738 QW------QARMLVMED--QHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKL 789
+ Q R+ ++ + +E E ++ + E+ +L A Q L+ +L
Sbjct: 1702 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1761
Query: 790 DHIQEQLE--------SKELERQNLETFKDRMTEESKVEAEL--HAERIEALRKQFQTER 839
++ ++E ++E R E K R+ E+ EL A R+ AL ++ + +R
Sbjct: 1762 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821
Query: 840 ETTKKVAQREVAELKKALDEANFRSVEVSRTNRE----LRQKLAELEKILESNKEKIKNQ 895
+ ++ A R+ AE ++ L E E +R E L++K AE E++ +++ +
Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1881
Query: 896 KTQIKLHLSAKANNAQNIERMKQIEK----EL-KQMELIKDQY-QKKNYEQSL-----SI 944
+ +L A + A ER+ Q+ K EL +Q L++D Q++ E+ + S
Sbjct: 1882 R---RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1938
Query: 945 QRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLK 1004
++ L+ E+ + + D +Q EL +R++ E E R +E EE V+
Sbjct: 1939 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1998
Query: 1005 KCKEATENTLKEASVESEQITANLEEAHRWFK--HRFDGLQLELTKNRLQ-RPSGEDR-- 1059
+E K A E E++ A +EEA R + + QL+L + Q R E++
Sbjct: 1999 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2058
Query: 1060 ---WQEKDQDVKHDVMSNQSVL 1078
Q+K+Q+++ + QSVL
Sbjct: 2059 AFAVQQKEQELQQTLQQEQSVL 2080
Score = 61.2 bits (147), Expect = 5e-09
Identities = 73/337 (21%), Positives = 145/337 (43%), Gaps = 42/337 (12%)
Query: 107 LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRA 166
L+ MQ+++ RL+ E +L Q+ +++ +QE+ + + L E ++ L A
Sbjct: 2316 LKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374
Query: 167 VKEEEDKAQDEVQRLTATL-----------KIASQTKKNAAIIEEELKTTKRKMNLKI-- 213
++ + + E +RL + + A + +K A I E+L T+ K+
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2434
Query: 214 ---------------QELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVER--KQVH 256
+ LR +A+ + +E L++ A + LK +EM TV+ E+ ++
Sbjct: 2435 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQ 2493
Query: 257 ILQQNCIALRDSIQSAQELLAQEQKKKEEL---EIATSQLKSDLTSRDDLISKLVEENKN 313
LQQ+ ++ +DS+ + + QE+ K E+L E+A +Q + R ++ +E +
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ--QQMEQERQR 2551
Query: 314 LQISF----NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKAR 369
L S ++HE +R + L + ++ + + L ++ L LQ + E+ R
Sbjct: 2552 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHR 2610
Query: 370 IIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNE 406
H + Q T+T LD A E
Sbjct: 2611 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2647
Score = 57.4 bits (137), Expect = 7e-08
Identities = 86/464 (18%), Positives = 178/464 (38%), Gaps = 43/464 (9%)
Query: 23 ATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQN 82
A + T L+ ++ + Q + L ++L L + E+L S +V Q
Sbjct: 2186 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV----QM 2241
Query: 83 EAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAI 142
E + K I +N +L+ K N R E+ ++ A RL+
Sbjct: 2242 EELSKLKARIEAEN-----------RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2290
Query: 143 QEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEEL 202
+E ++ +L ++ R + +E+ +A E RL A ++ Q K+ A L
Sbjct: 2291 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2350
Query: 203 KTTKRKMNLKIQE----LRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
+ K +M ++ E +R L E+ + + A + L++ EM +
Sbjct: 2351 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2410
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
++ + + + + ++ + LEI Q D + I++L E + LQ
Sbjct: 2411 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ--- 2467
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E L SE+ Q + + + E + Q+ EK ++ + +
Sbjct: 2468 -----------QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEKDSLL-QRERFI 2513
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQ----- 433
+ E+ + Q FQ++ + Q ++ E+ +L A ++ ++ +
Sbjct: 2514 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2573
Query: 434 --KAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKE 475
+ Q E++ Q+ELL RLR +L+ ++ ++ L E
Sbjct: 2574 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2617
Score = 47.8 bits (112), Expect = 6e-05
Identities = 208/1085 (19%), Positives = 422/1085 (38%), Gaps = 186/1085 (17%)
Query: 166 AVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEK- 224
A+ E E + + E +RL +I ++ + A + EE+L + ++ L ++
Sbjct: 380 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA 439
Query: 225 -YLRESLEKSASAMLLKIQEMGSTVEVERKQ-------VHILQQNCIALR---------- 266
+ L+K+ S + L ++ + + Q V+ L + +A+R
Sbjct: 440 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG 499
Query: 267 ---DSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHE 323
+ Q AQ L Q +++ ELE +T + DL + VEEN++ ++ +
Sbjct: 500 VAAPATQVAQVTL-QSVQRRPELEDSTLRYLQDLLA-------WVEENQH-RVDGAEWGV 550
Query: 324 ENAYLRSEIMS---LHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQV 380
+ + +++ S LH++ E+ + ++ +LS + D L +
Sbjct: 551 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA-------YRDCLGRLDL 603
Query: 381 EQKMMTQTFQEQNLLLDAAH---ASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQD 437
+ + + + + L++ H A+ T EL + NEK + + D N +K
Sbjct: 604 QYAKLLNSSKARLRSLESLHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKK--- 659
Query: 438 AEKRTAVQK--ELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNL 495
E +A+ + EL E I L+ + ++E E FQ + ++Q C +
Sbjct: 660 -ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCI 718
Query: 496 EKELAKNKV------DINTLTHNLQTLEE--ENKHLADQMASL-ELQQVTSDYHGLAQQK 546
E L +N D+ LQ L+E K+ D+ A++ L+ + D AQ +
Sbjct: 719 EAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQD----AQDE 774
Query: 547 VEKITESKNKLA----YENGKLQIK-------------------VKQLEEQVQSFTDTSL 583
E++ E K L+ +Q+K KQ+E V + L
Sbjct: 775 KEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL 834
Query: 584 QNDHLRKMNKYLQTKYAQA------------NSELSAKRVHLQQADAHL--------KEV 623
K L + ++A N E L+ L ++
Sbjct: 835 VGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 894
Query: 624 KSILE----RSKEELSRTVKCRNAALKESQKLKEDLEAVE------DRENKKVGNF---Q 670
KS+L R +L R+ + ++ ++ L ++E R+++ G F
Sbjct: 895 KSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPED 954
Query: 671 RQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQR-V 729
R +AE + +C + + +L S QGA E+ + + R SE+ ++ + + + R V
Sbjct: 955 RLMAEREYGSC--SHHYQQLL--QSLEQGAQEESRCQ--RCISELKDIRLQLEACETRTV 1008
Query: 730 QKLEAEVDQWQAR----MLVMEDQHNSEIESLQKALGVAR---EDNRKLAM--------- 773
+L +D+ AR + + + +E+E L K GVAR E + LA+
Sbjct: 1009 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK--GVARLSAEAEKVLALPEPSPAAPT 1066
Query: 774 ----------SLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEA-- 821
LEQ + KL I + + + L ++++ E V A
Sbjct: 1067 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1126
Query: 822 -ELHAER--IEALRKQFQTERETTKKVAQ--REVAELKKALDEAN-FRSVEVSRTNRELR 875
EL A + ++ LR Q + ++ T + R E+ + L + + R VEV R +
Sbjct: 1127 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1186
Query: 876 QKLAELEKIL---ESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQ 932
Q L + +L + + +++ Q++ + + ++ ++ +++++ M L Q
Sbjct: 1187 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1246
Query: 933 YQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQEL-----HLE------A 981
++ Q ++ + +E Q AK QY ++++ + +L LE
Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQRFAK-QYINAIKDYELQLVTYKAQLEPVASPAK 1305
Query: 982 ERKIRQELENRCQELEETVRHLKKCKEATENTLKEAS-----VESEQITANLEEAHRWFK 1036
+ K++ E+ QE + H + T +K S +E E+ A + A +
Sbjct: 1306 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--R 1363
Query: 1037 HRFDGLQLELTKNR-LQRPSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQNLRPMPKKYH 1095
R ++ L K R L + + Q + + + + V+ R E + + +
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 1096 SEVQR 1100
E+Q+
Sbjct: 1424 EELQQ 1428
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 146 bits (369), Expect = 9e-35
Identities = 242/1122 (21%), Positives = 466/1122 (41%), Gaps = 179/1122 (15%)
Query: 26 SETFTVLQQRMRIVEEQTSSLRDDLIMLDFG-EKRGYLEAPDCLEDLDSQKVISPIQNEA 84
SET +++ R+ E+Q + R+ L ++ EK+ L +++ +Q
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 85 ICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQE 144
+ + + E V+ + S+ + L+ R +E ++ + A Q
Sbjct: 1398 -----QEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAK----------ARQA 1440
Query: 145 EHSKDLKL-LHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELK 203
E ++ +L + E+ +R QL A + + A+ E+Q L A + A K+ A E L+
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 204 T-----TKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
++RK +++ R A+ + RE + L++Q + + + +V
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
+Q +AL + +SA+ A+ Q K+ T+QL+ L +++L EE
Sbjct: 1561 RQVQVALETAQRSAE---AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA------- 1610
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E A ++E E +E+ L K L LQ + + + +A +A
Sbjct: 1611 ----ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDA 438
Q E+ E + + K + QA + E Q ++K +
Sbjct: 1665 QKEEA----------------------EREARRRGKAEEQAVRQRELAE--QELEKQRQL 1700
Query: 439 EKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKE 498
+ TA Q+ E + RLR E E Q+++ L EE R QRE Q+R LE E
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA----TQKRQELEAE 1756
Query: 499 LAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQ--KVEKITES--- 553
LAK + ++ L + EEE++ +++ + L+ + LA++ ++ + E
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEK-SKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815
Query: 554 KNKLAYENGKLQI---------KVKQLEEQVQSFTDTSL-------QNDHLRKM------ 591
+ +LA E+ Q K+ + E + T+ + +N+ LR++
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 592 -NKYLQTKYAQANSELSAKRVHLQQA-DAHLKEVKSILE---RSKEELSRTVKCRNAALK 646
+ L+ + AQ +++ + L++A D+ L+ K ++E R + ++ + A+ +
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 647 ESQKLKEDLE---------AVEDRENKKVGNF----QRQLAEAKE-------DNCKVTIM 686
++ K +LE A + +K+ QRQLA +E + + ++
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 687 LENVLASHSKMQGALEKVQ-----IELGRRDSEIAGLKKERDLN------QQR------- 728
E A K ALE+V+ +E RR E A + R L Q+R
Sbjct: 1996 AEEEAARQRK--AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 729 ----VQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE-----------------D 767
VQ+ E E+ Q + + DQ E E+ ++A A E +
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 768 NRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAER 827
+L S E+ Q Q + ++++ E + R E R + + E E H +
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2173
Query: 828 IE-ALRKQFQTERE-TTKKVAQREVAELKKALDEANFR----SVEVSRTNRELRQKLAEL 881
E LR++ Q E+E TT ++ E K LDE R + E +R ++ ++L +
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 882 EKILES-NKEKIKNQKTQIKLHLSAKANNA----QNIERMKQIEKELKQMELIKDQYQKK 936
+E +K K + + L L K N + E+MKQ+ +E ++ + + +
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 937 NY--EQSLSIQRFVCEMTNLQKEMQMLAKS---QYDASVRNKQQELHLEAERKIRQELEN 991
E+ L+ QR + E L+++MQ + ++ + +A + +Q+EL E R+++++ E
Sbjct: 2294 RQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 992 RCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHR 1033
Q+L E + ++ EA E S E+E++ + E R
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394
Score = 141 bits (355), Expect = 4e-33
Identities = 214/985 (21%), Positives = 421/985 (42%), Gaps = 112/985 (11%)
Query: 138 RLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAI 197
RL A E+ + +LL E+ L+++ A ++ + + E+ ++ A +++ +K A
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-- 1774
Query: 198 IEEELKTT--KRKMNLKIQELR-RQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQ 254
EEE ++T K K L+ + R R+LA+E +L + A +E + E ++
Sbjct: 1775 -EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1833
Query: 255 VHILQQNCIALRDSIQSAQELLAQEQKKKEE---------------LEIATSQLKSDLTS 299
V + I +++ E+ +E++ + E LE +Q K+D+
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893
Query: 300 RDDLISKLVEENKNLQISFNKEH-EENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSC 358
R + K + Q ++ + + EI++L + EKA +L + +
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 359 MLQTV--TMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQ 416
+ + E+A + A Q L E++ + +E+ AA + + E +
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 417 LQAHLDHLIL-------EHNQCIQKAQDA-EKRTAVQKELLESTIARLRGELEASMQEKK 468
L+A ++ E + +Q AQ+A +KR +++ + + EL+ ++Q+++
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 469 SLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMA 528
S+L++ + +E + R E+E A+++ + Q+ EE+ + A A
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 529 SLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHL 588
+ E K+ K E + + + ++ KQ D ++ H
Sbjct: 2134 AAE--------------KLRKEAEQEAARRAQAEQAALRQKQA-------ADAEMEK-HK 2171
Query: 589 RKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKES 648
+ + L+ K AQ EL+ R+ L++ D + L+R K E + + R+ +E
Sbjct: 2172 KFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230
Query: 649 QKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIEL 708
++ +E + + ++ R L +DN + + E + Q A E ++ +
Sbjct: 2231 FSVRVQMEELS-KLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVAEEAARLSV 2285
Query: 709 GRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQH-NSEIESLQKALGVARED 767
+++ E DL QQR + ++ QA V E +E E LQ+ +A+E
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA---VQEATRLKAEAELLQQQKELAQEQ 2342
Query: 768 NRKLAMSLEQALQ-----TNNHLQTKLDHIQEQLE-SKELERQNLETFK-DRMTEESKVE 820
R+L EQ Q T +T Q QLE S E ER L + R ++ +
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2402
Query: 821 AELHAERIEAL-RKQFQTERETTKKVAQREVAELKKALDEANFRSVE--VSRTNRELRQK 877
A+ ++ E + K +TE T +KV + E+++ + + + ++ RE ++K
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEK 2461
Query: 878 LAELEKILESNKEKIKN-------QKTQIKLHLSAKANNAQNIERMKQIEKELKQME-LI 929
L + K+L+ E+++ Q+TQ L S + ++R + IE+E ++E L
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 930 KDQYQKKNY---EQSLSIQRFVCEMTNLQKEMQMLAKSQYDAS--VRNKQQELH-LEAER 983
+D+ K EQ Q+ E L M+ + Q++A VR KQ+EL LE +R
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWF-------- 1035
+ ++EL L E + L++ + E + A SE++TA+ A +
Sbjct: 2581 RQQEEL------LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2634
Query: 1036 --------KHRFDGLQLELTKNRLQ 1052
+H FDGL+ +++ RLQ
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQ 2659
Score = 132 bits (332), Expect = 2e-30
Identities = 217/1042 (20%), Positives = 433/1042 (41%), Gaps = 138/1042 (13%)
Query: 162 QQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMN--LKIQELRRQ 219
+++ A+ E A L TL Q + +AI E+LKT + +E+ R
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR- 1106
Query: 220 LAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQE 279
A E+ L+E+ ++ A L +++ ++++ R Q Q ALRD ++ AQE+ +
Sbjct: 1107 -AHEEQLKEA--QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1163
Query: 280 QKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEAS 339
Q++ E ++ + + + + ++ + Q + + Y R L
Sbjct: 1164 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1223
Query: 340 EKAQVLNDQL-TKKCSELSCMLQTVTMEKARI--IADH---------------QAILQVE 381
+ A+ +Q+ ++ + + + E+A + I H AI E
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283
Query: 382 QKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKR 441
+++T Q + + A + + ++V E L+ H L +Q I+ + +R
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1343
Query: 442 TAVQKELLESTIARLR---GELEASMQEKKSLLEE---------------KERFQREVNK 483
++ L E A R E+EA++++++ L E ++R Q EV +
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 484 TEKEIV---QERCNLEKELAK----NKVDINTLTHNLQTLEEENKHLADQMASLELQ-QV 535
E+ V Q++ ++++EL + ++ +I + E + +++ + LQ +
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463
Query: 536 TSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN---------- 585
T G A+ +++ + + + + Q + ++L QVQ + Q
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523
Query: 586 ---------------DHLRKMNKYLQTKYAQANSELS------------AKRVHLQQADA 618
+ LR + + + QA E + + LQ A
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 619 HLKEVKSILERS-KEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAK 677
E + LERS +EE + R A + +Q+ E A E+ E +++ +Q + EA
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEA- 1641
Query: 678 EDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVD 737
++ + E V S Q EK Q E R++ G +E+ + Q+ + + E E
Sbjct: 1642 ---LRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 738 QW------QARMLVMED--QHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKL 789
+ Q R+ ++ + +E E ++ + E+ +L A Q L+ +L
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757
Query: 790 DHIQEQLE--------SKELERQNLETFKDRMTEESKVEAEL--HAERIEALRKQFQTER 839
++ ++E ++E R E K R+ E+ EL A R+ AL ++ + +R
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 840 ETTKKVAQREVAELKKALDEANFRSVEVSRTNRE----LRQKLAELEKILESNKEKIKNQ 895
+ ++ A R+ AE ++ L E E +R E L++K AE E++ +++ +
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877
Query: 896 KTQIKLHLSAKANNAQNIERMKQIEK----EL-KQMELIKDQY-QKKNYEQSL-----SI 944
+ +L A + A ER+ Q+ K EL +Q L++D Q++ E+ + S
Sbjct: 1878 R---RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 945 QRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLK 1004
++ L+ E+ + + D +Q EL +R++ E E R +E EE V+
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994
Query: 1005 KCKEATENTLKEASVESEQITANLEEAHRWFK--HRFDGLQLELTKNRLQ-RPSGEDR-- 1059
+E K A E E++ A +EEA R + + QL+L + Q R E++
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054
Query: 1060 ---WQEKDQDVKHDVMSNQSVL 1078
Q+K+Q+++ + QSVL
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVL 2076
Score = 61.2 bits (147), Expect = 5e-09
Identities = 73/337 (21%), Positives = 145/337 (43%), Gaps = 42/337 (12%)
Query: 107 LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRA 166
L+ MQ+++ RL+ E +L Q+ +++ +QE+ + + L E ++ L A
Sbjct: 2312 LKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 167 VKEEEDKAQDEVQRLTATL-----------KIASQTKKNAAIIEEELKTTKRKMNLKI-- 213
++ + + E +RL + + A + +K A I E+L T+ K+
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 214 ---------------QELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVER--KQVH 256
+ LR +A+ + +E L++ A + LK +EM TV+ E+ ++
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQ 2489
Query: 257 ILQQNCIALRDSIQSAQELLAQEQKKKEEL---EIATSQLKSDLTSRDDLISKLVEENKN 313
LQQ+ ++ +DS+ + + QE+ K E+L E+A +Q + R ++ +E +
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ--QQMEQERQR 2547
Query: 314 LQISF----NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKAR 369
L S ++HE +R + L + ++ + + L ++ L LQ + E+ R
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHR 2606
Query: 370 IIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNE 406
H + Q T+T LD A E
Sbjct: 2607 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 57.4 bits (137), Expect = 7e-08
Identities = 86/464 (18%), Positives = 178/464 (38%), Gaps = 43/464 (9%)
Query: 23 ATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQN 82
A + T L+ ++ + Q + L ++L L + E+L S +V Q
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV----QM 2237
Query: 83 EAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAI 142
E + K I +N +L+ K N R E+ ++ A RL+
Sbjct: 2238 EELSKLKARIEAEN-----------RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 143 QEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEEL 202
+E ++ +L ++ R + +E+ +A E RL A ++ Q K+ A L
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2346
Query: 203 KTTKRKMNLKIQE----LRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
+ K +M ++ E +R L E+ + + A + L++ EM +
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
++ + + + + ++ + LEI Q D + I++L E + LQ
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ--- 2463
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E L SE+ Q + + + E + Q+ EK ++ + +
Sbjct: 2464 -----------QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEKDSLL-QRERFI 2509
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQ----- 433
+ E+ + Q FQ++ + Q ++ E+ +L A ++ ++ +
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 434 --KAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKE 475
+ Q E++ Q+ELL RLR +L+ ++ ++ L E
Sbjct: 2570 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2613
Score = 47.8 bits (112), Expect = 6e-05
Identities = 208/1085 (19%), Positives = 422/1085 (38%), Gaps = 186/1085 (17%)
Query: 166 AVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEK- 224
A+ E E + + E +RL +I ++ + A + EE+L + ++ L ++
Sbjct: 376 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA 435
Query: 225 -YLRESLEKSASAMLLKIQEMGSTVEVERKQ-------VHILQQNCIALR---------- 266
+ L+K+ S + L ++ + + Q V+ L + +A+R
Sbjct: 436 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG 495
Query: 267 ---DSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHE 323
+ Q AQ L Q +++ ELE +T + DL + VEEN++ ++ +
Sbjct: 496 VAAPATQVAQVTL-QSVQRRPELEDSTLRYLQDLLA-------WVEENQH-RVDGAEWGV 546
Query: 324 ENAYLRSEIMS---LHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQV 380
+ + +++ S LH++ E+ + ++ +LS + D L +
Sbjct: 547 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA-------YRDCLGRLDL 599
Query: 381 EQKMMTQTFQEQNLLLDAAH---ASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQD 437
+ + + + + L++ H A+ T EL + NEK + + D N +K
Sbjct: 600 QYAKLLNSSKARLRSLESLHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKK--- 655
Query: 438 AEKRTAVQK--ELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNL 495
E +A+ + EL E I L+ + ++E E FQ + ++Q C +
Sbjct: 656 -ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCI 714
Query: 496 EKELAKNKV------DINTLTHNLQTLEE--ENKHLADQMASL-ELQQVTSDYHGLAQQK 546
E L +N D+ LQ L+E K+ D+ A++ L+ + D AQ +
Sbjct: 715 EAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQD----AQDE 770
Query: 547 VEKITESKNKLA----YENGKLQIK-------------------VKQLEEQVQSFTDTSL 583
E++ E K L+ +Q+K KQ+E V + L
Sbjct: 771 KEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL 830
Query: 584 QNDHLRKMNKYLQTKYAQA------------NSELSAKRVHLQQADAHL--------KEV 623
K L + ++A N E L+ L ++
Sbjct: 831 VGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 890
Query: 624 KSILE----RSKEELSRTVKCRNAALKESQKLKEDLEAVE------DRENKKVGNF---Q 670
KS+L R +L R+ + ++ ++ L ++E R+++ G F
Sbjct: 891 KSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPED 950
Query: 671 RQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQR-V 729
R +AE + +C + + +L S QGA E+ + + R SE+ ++ + + + R V
Sbjct: 951 RLMAEREYGSC--SHHYQQLL--QSLEQGAQEESRCQ--RCISELKDIRLQLEACETRTV 1004
Query: 730 QKLEAEVDQWQAR----MLVMEDQHNSEIESLQKALGVAR---EDNRKLAM--------- 773
+L +D+ AR + + + +E+E L K GVAR E + LA+
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK--GVARLSAEAEKVLALPEPSPAAPT 1062
Query: 774 ----------SLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEA-- 821
LEQ + KL I + + + L ++++ E V A
Sbjct: 1063 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1122
Query: 822 -ELHAER--IEALRKQFQTERETTKKVAQ--REVAELKKALDEAN-FRSVEVSRTNRELR 875
EL A + ++ LR Q + ++ T + R E+ + L + + R VEV R +
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 876 QKLAELEKIL---ESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQ 932
Q L + +L + + +++ Q++ + + ++ ++ +++++ M L Q
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 933 YQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQEL-----HLE------A 981
++ Q ++ + +E Q AK QY ++++ + +L LE
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAK-QYINAIKDYELQLVTYKAQLEPVASPAK 1301
Query: 982 ERKIRQELENRCQELEETVRHLKKCKEATENTLKEAS-----VESEQITANLEEAHRWFK 1036
+ K++ E+ QE + H + T +K S +E E+ A + A +
Sbjct: 1302 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--R 1359
Query: 1037 HRFDGLQLELTKNR-LQRPSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQNLRPMPKKYH 1095
R ++ L K R L + + Q + + + + V+ R E + + +
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 1096 SEVQR 1100
E+Q+
Sbjct: 1420 EELQQ 1424
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 146 bits (369), Expect = 9e-35
Identities = 242/1122 (21%), Positives = 466/1122 (41%), Gaps = 179/1122 (15%)
Query: 26 SETFTVLQQRMRIVEEQTSSLRDDLIMLDFG-EKRGYLEAPDCLEDLDSQKVISPIQNEA 84
SET +++ R+ E+Q + R+ L ++ EK+ L +++ +Q
Sbjct: 1306 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1365
Query: 85 ICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQE 144
+ + + E V+ + S+ + L+ R +E ++ + A Q
Sbjct: 1366 -----QEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAK----------ARQA 1408
Query: 145 EHSKDLKL-LHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELK 203
E ++ +L + E+ +R QL A + + A+ E+Q L A + A K+ A E L+
Sbjct: 1409 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1468
Query: 204 T-----TKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
++RK +++ R A+ + RE + L++Q + + + +V
Sbjct: 1469 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1528
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
+Q +AL + +SA+ A+ Q K+ T+QL+ L +++L EE
Sbjct: 1529 RQVQVALETAQRSAE---AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA------- 1578
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E A ++E E +E+ L K L LQ + + + +A +A
Sbjct: 1579 ----ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1632
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDA 438
Q E+ E + + K + QA + E Q ++K +
Sbjct: 1633 QKEEA----------------------EREARRRGKAEEQAVRQRELAE--QELEKQRQL 1668
Query: 439 EKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKE 498
+ TA Q+ E + RLR E E Q+++ L EE R QRE Q+R LE E
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA----TQKRQELEAE 1724
Query: 499 LAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQ--KVEKITES--- 553
LAK + ++ L + EEE++ +++ + L+ + LA++ ++ + E
Sbjct: 1725 LAKVRAEMEVLLASKARAEEESRSTSEK-SKQRLEAEAGRFRELAEEAARLRALAEEAKR 1783
Query: 554 KNKLAYENGKLQI---------KVKQLEEQVQSFTDTSL-------QNDHLRKM------ 591
+ +LA E+ Q K+ + E + T+ + +N+ LR++
Sbjct: 1784 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843
Query: 592 -NKYLQTKYAQANSELSAKRVHLQQA-DAHLKEVKSILE---RSKEELSRTVKCRNAALK 646
+ L+ + AQ +++ + L++A D+ L+ K ++E R + ++ + A+ +
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903
Query: 647 ESQKLKEDLE---------AVEDRENKKVGNF----QRQLAEAKE-------DNCKVTIM 686
++ K +LE A + +K+ QRQLA +E + + ++
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963
Query: 687 LENVLASHSKMQGALEKVQ-----IELGRRDSEIAGLKKERDLN------QQR------- 728
E A K ALE+V+ +E RR E A + R L Q+R
Sbjct: 1964 AEEEAARQRK--AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2021
Query: 729 ----VQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE-----------------D 767
VQ+ E E+ Q + + DQ E E+ ++A A E +
Sbjct: 2022 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2081
Query: 768 NRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAER 827
+L S E+ Q Q + ++++ E + R E R + + E E H +
Sbjct: 2082 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2141
Query: 828 IE-ALRKQFQTERE-TTKKVAQREVAELKKALDEANFR----SVEVSRTNRELRQKLAEL 881
E LR++ Q E+E TT ++ E K LDE R + E +R ++ ++L +
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2201
Query: 882 EKILES-NKEKIKNQKTQIKLHLSAKANNA----QNIERMKQIEKELKQMELIKDQYQKK 936
+E +K K + + L L K N + E+MKQ+ +E ++ + + +
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261
Query: 937 NY--EQSLSIQRFVCEMTNLQKEMQMLAKS---QYDASVRNKQQELHLEAERKIRQELEN 991
E+ L+ QR + E L+++MQ + ++ + +A + +Q+EL E R+++++ E
Sbjct: 2262 RQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320
Query: 992 RCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHR 1033
Q+L E + ++ EA E S E+E++ + E R
Sbjct: 2321 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2362
Score = 141 bits (355), Expect = 4e-33
Identities = 214/985 (21%), Positives = 421/985 (42%), Gaps = 112/985 (11%)
Query: 138 RLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAI 197
RL A E+ + +LL E+ L+++ A ++ + + E+ ++ A +++ +K A
Sbjct: 1685 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-- 1742
Query: 198 IEEELKTT--KRKMNLKIQELR-RQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQ 254
EEE ++T K K L+ + R R+LA+E +L + A +E + E ++
Sbjct: 1743 -EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1801
Query: 255 VHILQQNCIALRDSIQSAQELLAQEQKKKEE---------------LEIATSQLKSDLTS 299
V + I +++ E+ +E++ + E LE +Q K+D+
Sbjct: 1802 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1861
Query: 300 RDDLISKLVEENKNLQISFNKEH-EENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSC 358
R + K + Q ++ + + EI++L + EKA +L + +
Sbjct: 1862 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1921
Query: 359 MLQTV--TMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQ 416
+ + E+A + A Q L E++ + +E+ AA + + E +
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Query: 417 LQAHLDHLIL-------EHNQCIQKAQDA-EKRTAVQKELLESTIARLRGELEASMQEKK 468
L+A ++ E + +Q AQ+A +KR +++ + + EL+ ++Q+++
Sbjct: 1982 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2041
Query: 469 SLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMA 528
S+L++ + +E + R E+E A+++ + Q+ EE+ + A A
Sbjct: 2042 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2101
Query: 529 SLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHL 588
+ E K+ K E + + + ++ KQ D ++ H
Sbjct: 2102 AAE--------------KLRKEAEQEAARRAQAEQAALRQKQA-------ADAEMEK-HK 2139
Query: 589 RKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKES 648
+ + L+ K AQ EL+ R+ L++ D + L+R K E + + R+ +E
Sbjct: 2140 KFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2198
Query: 649 QKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIEL 708
++ +E + + ++ R L +DN + + E + Q A E ++ +
Sbjct: 2199 FSVRVQMEELS-KLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVAEEAARLSV 2253
Query: 709 GRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQH-NSEIESLQKALGVARED 767
+++ E DL QQR + ++ QA V E +E E LQ+ +A+E
Sbjct: 2254 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA---VQEATRLKAEAELLQQQKELAQEQ 2310
Query: 768 NRKLAMSLEQALQ-----TNNHLQTKLDHIQEQLE-SKELERQNLETFK-DRMTEESKVE 820
R+L EQ Q T +T Q QLE S E ER L + R ++ +
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2370
Query: 821 AELHAERIEAL-RKQFQTERETTKKVAQREVAELKKALDEANFRSVE--VSRTNRELRQK 877
A+ ++ E + K +TE T +KV + E+++ + + + ++ RE ++K
Sbjct: 2371 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEK 2429
Query: 878 LAELEKILESNKEKIKN-------QKTQIKLHLSAKANNAQNIERMKQIEKELKQME-LI 929
L + K+L+ E+++ Q+TQ L S + ++R + IE+E ++E L
Sbjct: 2430 LQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2488
Query: 930 KDQYQKKNY---EQSLSIQRFVCEMTNLQKEMQMLAKSQYDAS--VRNKQQELH-LEAER 983
+D+ K EQ Q+ E L M+ + Q++A VR KQ+EL LE +R
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2548
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWF-------- 1035
+ ++EL L E + L++ + E + A SE++TA+ A +
Sbjct: 2549 RQQEEL------LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2602
Query: 1036 --------KHRFDGLQLELTKNRLQ 1052
+H FDGL+ +++ RLQ
Sbjct: 2603 GPAAEAEPEHSFDGLRRKVSAQRLQ 2627
Score = 132 bits (332), Expect = 2e-30
Identities = 217/1042 (20%), Positives = 433/1042 (41%), Gaps = 138/1042 (13%)
Query: 162 QQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMN--LKIQELRRQ 219
+++ A+ E A L TL Q + +AI E+LKT + +E+ R
Sbjct: 1016 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR- 1074
Query: 220 LAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQE 279
A E+ L+E+ ++ A L +++ ++++ R Q Q ALRD ++ AQE+ +
Sbjct: 1075 -AHEEQLKEA--QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1131
Query: 280 QKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEAS 339
Q++ E ++ + + + + ++ + Q + + Y R L
Sbjct: 1132 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1191
Query: 340 EKAQVLNDQL-TKKCSELSCMLQTVTMEKARI--IADH---------------QAILQVE 381
+ A+ +Q+ ++ + + + E+A + I H AI E
Sbjct: 1192 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1251
Query: 382 QKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKR 441
+++T Q + + A + + ++V E L+ H L +Q I+ + +R
Sbjct: 1252 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1311
Query: 442 TAVQKELLESTIARLR---GELEASMQEKKSLLEE---------------KERFQREVNK 483
++ L E A R E+EA++++++ L E ++R Q EV +
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 484 TEKEIV---QERCNLEKELAK----NKVDINTLTHNLQTLEEENKHLADQMASLELQ-QV 535
E+ V Q++ ++++EL + ++ +I + E + +++ + LQ +
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1431
Query: 536 TSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN---------- 585
T G A+ +++ + + + + Q + ++L QVQ + Q
Sbjct: 1432 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1491
Query: 586 ---------------DHLRKMNKYLQTKYAQANSELS------------AKRVHLQQADA 618
+ LR + + + QA E + + LQ A
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1551
Query: 619 HLKEVKSILERS-KEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAK 677
E + LERS +EE + R A + +Q+ E A E+ E +++ +Q + EA
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEA- 1609
Query: 678 EDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVD 737
++ + E V S Q EK Q E R++ G +E+ + Q+ + + E E
Sbjct: 1610 ---LRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665
Query: 738 QW------QARMLVMED--QHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKL 789
+ Q R+ ++ + +E E ++ + E+ +L A Q L+ +L
Sbjct: 1666 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1725
Query: 790 DHIQEQLE--------SKELERQNLETFKDRMTEESKVEAEL--HAERIEALRKQFQTER 839
++ ++E ++E R E K R+ E+ EL A R+ AL ++ + +R
Sbjct: 1726 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785
Query: 840 ETTKKVAQREVAELKKALDEANFRSVEVSRTNRE----LRQKLAELEKILESNKEKIKNQ 895
+ ++ A R+ AE ++ L E E +R E L++K AE E++ +++ +
Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1845
Query: 896 KTQIKLHLSAKANNAQNIERMKQIEK----EL-KQMELIKDQY-QKKNYEQSL-----SI 944
+ +L A + A ER+ Q+ K EL +Q L++D Q++ E+ + S
Sbjct: 1846 R---RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1902
Query: 945 QRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLK 1004
++ L+ E+ + + D +Q EL +R++ E E R +E EE V+
Sbjct: 1903 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1962
Query: 1005 KCKEATENTLKEASVESEQITANLEEAHRWFK--HRFDGLQLELTKNRLQ-RPSGEDR-- 1059
+E K A E E++ A +EEA R + + QL+L + Q R E++
Sbjct: 1963 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2022
Query: 1060 ---WQEKDQDVKHDVMSNQSVL 1078
Q+K+Q+++ + QSVL
Sbjct: 2023 AFAVQQKEQELQQTLQQEQSVL 2044
Score = 61.2 bits (147), Expect = 5e-09
Identities = 73/337 (21%), Positives = 145/337 (43%), Gaps = 42/337 (12%)
Query: 107 LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRA 166
L+ MQ+++ RL+ E +L Q+ +++ +QE+ + + L E ++ L A
Sbjct: 2280 LKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338
Query: 167 VKEEEDKAQDEVQRLTATL-----------KIASQTKKNAAIIEEELKTTKRKMNLKI-- 213
++ + + E +RL + + A + +K A I E+L T+ K+
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2398
Query: 214 ---------------QELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVER--KQVH 256
+ LR +A+ + +E L++ A + LK +EM TV+ E+ ++
Sbjct: 2399 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQ 2457
Query: 257 ILQQNCIALRDSIQSAQELLAQEQKKKEEL---EIATSQLKSDLTSRDDLISKLVEENKN 313
LQQ+ ++ +DS+ + + QE+ K E+L E+A +Q + R ++ +E +
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ--QQMEQERQR 2515
Query: 314 LQISF----NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKAR 369
L S ++HE +R + L + ++ + + L ++ L LQ + E+ R
Sbjct: 2516 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHR 2574
Query: 370 IIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNE 406
H + Q T+T LD A E
Sbjct: 2575 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2611
Score = 57.4 bits (137), Expect = 7e-08
Identities = 86/464 (18%), Positives = 178/464 (38%), Gaps = 43/464 (9%)
Query: 23 ATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQN 82
A + T L+ ++ + Q + L ++L L + E+L S +V Q
Sbjct: 2150 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV----QM 2205
Query: 83 EAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAI 142
E + K I +N +L+ K N R E+ ++ A RL+
Sbjct: 2206 EELSKLKARIEAEN-----------RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2254
Query: 143 QEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEEL 202
+E ++ +L ++ R + +E+ +A E RL A ++ Q K+ A L
Sbjct: 2255 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2314
Query: 203 KTTKRKMNLKIQE----LRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
+ K +M ++ E +R L E+ + + A + L++ EM +
Sbjct: 2315 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2374
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
++ + + + + ++ + LEI Q D + I++L E + LQ
Sbjct: 2375 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ--- 2431
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E L SE+ Q + + + E + Q+ EK ++ + +
Sbjct: 2432 -----------QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEKDSLL-QRERFI 2477
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQ----- 433
+ E+ + Q FQ++ + Q ++ E+ +L A ++ ++ +
Sbjct: 2478 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2537
Query: 434 --KAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKE 475
+ Q E++ Q+ELL RLR +L+ ++ ++ L E
Sbjct: 2538 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2581
Score = 47.8 bits (112), Expect = 6e-05
Identities = 208/1085 (19%), Positives = 422/1085 (38%), Gaps = 186/1085 (17%)
Query: 166 AVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEK- 224
A+ E E + + E +RL +I ++ + A + EE+L + ++ L ++
Sbjct: 344 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA 403
Query: 225 -YLRESLEKSASAMLLKIQEMGSTVEVERKQ-------VHILQQNCIALR---------- 266
+ L+K+ S + L ++ + + Q V+ L + +A+R
Sbjct: 404 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG 463
Query: 267 ---DSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHE 323
+ Q AQ L Q +++ ELE +T + DL + VEEN++ ++ +
Sbjct: 464 VAAPATQVAQVTL-QSVQRRPELEDSTLRYLQDLLA-------WVEENQH-RVDGAEWGV 514
Query: 324 ENAYLRSEIMS---LHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQV 380
+ + +++ S LH++ E+ + ++ +LS + D L +
Sbjct: 515 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA-------YRDCLGRLDL 567
Query: 381 EQKMMTQTFQEQNLLLDAAH---ASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQD 437
+ + + + + L++ H A+ T EL + NEK + + D N +K
Sbjct: 568 QYAKLLNSSKARLRSLESLHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKK--- 623
Query: 438 AEKRTAVQK--ELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNL 495
E +A+ + EL E I L+ + ++E E FQ + ++Q C +
Sbjct: 624 -ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCI 682
Query: 496 EKELAKNKV------DINTLTHNLQTLEE--ENKHLADQMASL-ELQQVTSDYHGLAQQK 546
E L +N D+ LQ L+E K+ D+ A++ L+ + D AQ +
Sbjct: 683 EAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQD----AQDE 738
Query: 547 VEKITESKNKLA----YENGKLQIK-------------------VKQLEEQVQSFTDTSL 583
E++ E K L+ +Q+K KQ+E V + L
Sbjct: 739 KEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL 798
Query: 584 QNDHLRKMNKYLQTKYAQA------------NSELSAKRVHLQQADAHL--------KEV 623
K L + ++A N E L+ L ++
Sbjct: 799 VGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 858
Query: 624 KSILE----RSKEELSRTVKCRNAALKESQKLKEDLEAVE------DRENKKVGNF---Q 670
KS+L R +L R+ + ++ ++ L ++E R+++ G F
Sbjct: 859 KSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPED 918
Query: 671 RQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQR-V 729
R +AE + +C + + +L S QGA E+ + + R SE+ ++ + + + R V
Sbjct: 919 RLMAEREYGSC--SHHYQQLL--QSLEQGAQEESRCQ--RCISELKDIRLQLEACETRTV 972
Query: 730 QKLEAEVDQWQAR----MLVMEDQHNSEIESLQKALGVAR---EDNRKLAM--------- 773
+L +D+ AR + + + +E+E L K GVAR E + LA+
Sbjct: 973 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK--GVARLSAEAEKVLALPEPSPAAPT 1030
Query: 774 ----------SLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEA-- 821
LEQ + KL I + + + L ++++ E V A
Sbjct: 1031 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1090
Query: 822 -ELHAER--IEALRKQFQTERETTKKVAQ--REVAELKKALDEAN-FRSVEVSRTNRELR 875
EL A + ++ LR Q + ++ T + R E+ + L + + R VEV R +
Sbjct: 1091 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1150
Query: 876 QKLAELEKIL---ESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQ 932
Q L + +L + + +++ Q++ + + ++ ++ +++++ M L Q
Sbjct: 1151 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1210
Query: 933 YQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQEL-----HLE------A 981
++ Q ++ + +E Q AK QY ++++ + +L LE
Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQRFAK-QYINAIKDYELQLVTYKAQLEPVASPAK 1269
Query: 982 ERKIRQELENRCQELEETVRHLKKCKEATENTLKEAS-----VESEQITANLEEAHRWFK 1036
+ K++ E+ QE + H + T +K S +E E+ A + A +
Sbjct: 1270 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--R 1327
Query: 1037 HRFDGLQLELTKNR-LQRPSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQNLRPMPKKYH 1095
R ++ L K R L + + Q + + + + V+ R E + + +
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 1096 SEVQR 1100
E+Q+
Sbjct: 1388 EELQQ 1392
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 146 bits (369), Expect = 9e-35
Identities = 242/1122 (21%), Positives = 466/1122 (41%), Gaps = 179/1122 (15%)
Query: 26 SETFTVLQQRMRIVEEQTSSLRDDLIMLDFG-EKRGYLEAPDCLEDLDSQKVISPIQNEA 84
SET +++ R+ E+Q + R+ L ++ EK+ L +++ +Q
Sbjct: 1475 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1534
Query: 85 ICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQE 144
+ + + E V+ + S+ + L+ R +E ++ + A Q
Sbjct: 1535 -----QEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAK----------ARQA 1577
Query: 145 EHSKDLKL-LHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELK 203
E ++ +L + E+ +R QL A + + A+ E+Q L A + A K+ A E L+
Sbjct: 1578 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1637
Query: 204 T-----TKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
++RK +++ R A+ + RE + L++Q + + + +V
Sbjct: 1638 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1697
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
+Q +AL + +SA+ A+ Q K+ T+QL+ L +++L EE
Sbjct: 1698 RQVQVALETAQRSAE---AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA------- 1747
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E A ++E E +E+ L K L LQ + + + +A +A
Sbjct: 1748 ----ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1801
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDA 438
Q E+ E + + K + QA + E Q ++K +
Sbjct: 1802 QKEEA----------------------EREARRRGKAEEQAVRQRELAE--QELEKQRQL 1837
Query: 439 EKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKE 498
+ TA Q+ E + RLR E E Q+++ L EE R QRE Q+R LE E
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA----TQKRQELEAE 1893
Query: 499 LAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQ--KVEKITES--- 553
LAK + ++ L + EEE++ +++ + L+ + LA++ ++ + E
Sbjct: 1894 LAKVRAEMEVLLASKARAEEESRSTSEK-SKQRLEAEAGRFRELAEEAARLRALAEEAKR 1952
Query: 554 KNKLAYENGKLQI---------KVKQLEEQVQSFTDTSL-------QNDHLRKM------ 591
+ +LA E+ Q K+ + E + T+ + +N+ LR++
Sbjct: 1953 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012
Query: 592 -NKYLQTKYAQANSELSAKRVHLQQA-DAHLKEVKSILE---RSKEELSRTVKCRNAALK 646
+ L+ + AQ +++ + L++A D+ L+ K ++E R + ++ + A+ +
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072
Query: 647 ESQKLKEDLE---------AVEDRENKKVGNF----QRQLAEAKE-------DNCKVTIM 686
++ K +LE A + +K+ QRQLA +E + + ++
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132
Query: 687 LENVLASHSKMQGALEKVQ-----IELGRRDSEIAGLKKERDLN------QQR------- 728
E A K ALE+V+ +E RR E A + R L Q+R
Sbjct: 2133 AEEEAARQRK--AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2190
Query: 729 ----VQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE-----------------D 767
VQ+ E E+ Q + + DQ E E+ ++A A E +
Sbjct: 2191 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2250
Query: 768 NRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAER 827
+L S E+ Q Q + ++++ E + R E R + + E E H +
Sbjct: 2251 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2310
Query: 828 IE-ALRKQFQTERE-TTKKVAQREVAELKKALDEANFR----SVEVSRTNRELRQKLAEL 881
E LR++ Q E+E TT ++ E K LDE R + E +R ++ ++L +
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370
Query: 882 EKILES-NKEKIKNQKTQIKLHLSAKANNA----QNIERMKQIEKELKQMELIKDQYQKK 936
+E +K K + + L L K N + E+MKQ+ +E ++ + + +
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430
Query: 937 NY--EQSLSIQRFVCEMTNLQKEMQMLAKS---QYDASVRNKQQELHLEAERKIRQELEN 991
E+ L+ QR + E L+++MQ + ++ + +A + +Q+EL E R+++++ E
Sbjct: 2431 RQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489
Query: 992 RCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHR 1033
Q+L E + ++ EA E S E+E++ + E R
Sbjct: 2490 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2531
Score = 141 bits (355), Expect = 4e-33
Identities = 214/985 (21%), Positives = 421/985 (42%), Gaps = 112/985 (11%)
Query: 138 RLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAI 197
RL A E+ + +LL E+ L+++ A ++ + + E+ ++ A +++ +K A
Sbjct: 1854 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-- 1911
Query: 198 IEEELKTT--KRKMNLKIQELR-RQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQ 254
EEE ++T K K L+ + R R+LA+E +L + A +E + E ++
Sbjct: 1912 -EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1970
Query: 255 VHILQQNCIALRDSIQSAQELLAQEQKKKEE---------------LEIATSQLKSDLTS 299
V + I +++ E+ +E++ + E LE +Q K+D+
Sbjct: 1971 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 2030
Query: 300 RDDLISKLVEENKNLQISFNKEH-EENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSC 358
R + K + Q ++ + + EI++L + EKA +L + +
Sbjct: 2031 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 2090
Query: 359 MLQTV--TMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQ 416
+ + E+A + A Q L E++ + +E+ AA + + E +
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 417 LQAHLDHLIL-------EHNQCIQKAQDA-EKRTAVQKELLESTIARLRGELEASMQEKK 468
L+A ++ E + +Q AQ+A +KR +++ + + EL+ ++Q+++
Sbjct: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2210
Query: 469 SLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMA 528
S+L++ + +E + R E+E A+++ + Q+ EE+ + A A
Sbjct: 2211 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2270
Query: 529 SLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHL 588
+ E K+ K E + + + ++ KQ D ++ H
Sbjct: 2271 AAE--------------KLRKEAEQEAARRAQAEQAALRQKQA-------ADAEMEK-HK 2308
Query: 589 RKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKES 648
+ + L+ K AQ EL+ R+ L++ D + L+R K E + + R+ +E
Sbjct: 2309 KFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2367
Query: 649 QKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIEL 708
++ +E + + ++ R L +DN + + E + Q A E ++ +
Sbjct: 2368 FSVRVQMEELS-KLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVAEEAARLSV 2422
Query: 709 GRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQH-NSEIESLQKALGVARED 767
+++ E DL QQR + ++ QA V E +E E LQ+ +A+E
Sbjct: 2423 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA---VQEATRLKAEAELLQQQKELAQEQ 2479
Query: 768 NRKLAMSLEQALQ-----TNNHLQTKLDHIQEQLE-SKELERQNLETFK-DRMTEESKVE 820
R+L EQ Q T +T Q QLE S E ER L + R ++ +
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2539
Query: 821 AELHAERIEAL-RKQFQTERETTKKVAQREVAELKKALDEANFRSVE--VSRTNRELRQK 877
A+ ++ E + K +TE T +KV + E+++ + + + ++ RE ++K
Sbjct: 2540 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEK 2598
Query: 878 LAELEKILESNKEKIKN-------QKTQIKLHLSAKANNAQNIERMKQIEKELKQME-LI 929
L + K+L+ E+++ Q+TQ L S + ++R + IE+E ++E L
Sbjct: 2599 LQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657
Query: 930 KDQYQKKNY---EQSLSIQRFVCEMTNLQKEMQMLAKSQYDAS--VRNKQQELH-LEAER 983
+D+ K EQ Q+ E L M+ + Q++A VR KQ+EL LE +R
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2717
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWF-------- 1035
+ ++EL L E + L++ + E + A SE++TA+ A +
Sbjct: 2718 RQQEEL------LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2771
Query: 1036 --------KHRFDGLQLELTKNRLQ 1052
+H FDGL+ +++ RLQ
Sbjct: 2772 GPAAEAEPEHSFDGLRRKVSAQRLQ 2796
Score = 132 bits (332), Expect = 2e-30
Identities = 217/1042 (20%), Positives = 433/1042 (41%), Gaps = 138/1042 (13%)
Query: 162 QQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMN--LKIQELRRQ 219
+++ A+ E A L TL Q + +AI E+LKT + +E+ R
Sbjct: 1185 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR- 1243
Query: 220 LAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQE 279
A E+ L+E+ ++ A L +++ ++++ R Q Q ALRD ++ AQE+ +
Sbjct: 1244 -AHEEQLKEA--QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1300
Query: 280 QKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEAS 339
Q++ E ++ + + + + ++ + Q + + Y R L
Sbjct: 1301 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1360
Query: 340 EKAQVLNDQL-TKKCSELSCMLQTVTMEKARI--IADH---------------QAILQVE 381
+ A+ +Q+ ++ + + + E+A + I H AI E
Sbjct: 1361 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1420
Query: 382 QKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKR 441
+++T Q + + A + + ++V E L+ H L +Q I+ + +R
Sbjct: 1421 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1480
Query: 442 TAVQKELLESTIARLR---GELEASMQEKKSLLEE---------------KERFQREVNK 483
++ L E A R E+EA++++++ L E ++R Q EV +
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 484 TEKEIV---QERCNLEKELAK----NKVDINTLTHNLQTLEEENKHLADQMASLELQ-QV 535
E+ V Q++ ++++EL + ++ +I + E + +++ + LQ +
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1600
Query: 536 TSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN---------- 585
T G A+ +++ + + + + Q + ++L QVQ + Q
Sbjct: 1601 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1660
Query: 586 ---------------DHLRKMNKYLQTKYAQANSELS------------AKRVHLQQADA 618
+ LR + + + QA E + + LQ A
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1720
Query: 619 HLKEVKSILERS-KEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAK 677
E + LERS +EE + R A + +Q+ E A E+ E +++ +Q + EA
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEA- 1778
Query: 678 EDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVD 737
++ + E V S Q EK Q E R++ G +E+ + Q+ + + E E
Sbjct: 1779 ---LRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834
Query: 738 QW------QARMLVMED--QHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKL 789
+ Q R+ ++ + +E E ++ + E+ +L A Q L+ +L
Sbjct: 1835 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1894
Query: 790 DHIQEQLE--------SKELERQNLETFKDRMTEESKVEAEL--HAERIEALRKQFQTER 839
++ ++E ++E R E K R+ E+ EL A R+ AL ++ + +R
Sbjct: 1895 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954
Query: 840 ETTKKVAQREVAELKKALDEANFRSVEVSRTNRE----LRQKLAELEKILESNKEKIKNQ 895
+ ++ A R+ AE ++ L E E +R E L++K AE E++ +++ +
Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 2014
Query: 896 KTQIKLHLSAKANNAQNIERMKQIEK----EL-KQMELIKDQY-QKKNYEQSL-----SI 944
+ +L A + A ER+ Q+ K EL +Q L++D Q++ E+ + S
Sbjct: 2015 R---RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 2071
Query: 945 QRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLK 1004
++ L+ E+ + + D +Q EL +R++ E E R +E EE V+
Sbjct: 2072 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2131
Query: 1005 KCKEATENTLKEASVESEQITANLEEAHRWFK--HRFDGLQLELTKNRLQ-RPSGEDR-- 1059
+E K A E E++ A +EEA R + + QL+L + Q R E++
Sbjct: 2132 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2191
Query: 1060 ---WQEKDQDVKHDVMSNQSVL 1078
Q+K+Q+++ + QSVL
Sbjct: 2192 AFAVQQKEQELQQTLQQEQSVL 2213
Score = 61.2 bits (147), Expect = 5e-09
Identities = 73/337 (21%), Positives = 145/337 (43%), Gaps = 42/337 (12%)
Query: 107 LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRA 166
L+ MQ+++ RL+ E +L Q+ +++ +QE+ + + L E ++ L A
Sbjct: 2449 LKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507
Query: 167 VKEEEDKAQDEVQRLTATL-----------KIASQTKKNAAIIEEELKTTKRKMNLKI-- 213
++ + + E +RL + + A + +K A I E+L T+ K+
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2567
Query: 214 ---------------QELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVER--KQVH 256
+ LR +A+ + +E L++ A + LK +EM TV+ E+ ++
Sbjct: 2568 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQ 2626
Query: 257 ILQQNCIALRDSIQSAQELLAQEQKKKEEL---EIATSQLKSDLTSRDDLISKLVEENKN 313
LQQ+ ++ +DS+ + + QE+ K E+L E+A +Q + R ++ +E +
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ--QQMEQERQR 2684
Query: 314 LQISF----NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKAR 369
L S ++HE +R + L + ++ + + L ++ L LQ + E+ R
Sbjct: 2685 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHR 2743
Query: 370 IIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNE 406
H + Q T+T LD A E
Sbjct: 2744 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2780
Score = 57.4 bits (137), Expect = 7e-08
Identities = 86/464 (18%), Positives = 178/464 (38%), Gaps = 43/464 (9%)
Query: 23 ATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQN 82
A + T L+ ++ + Q + L ++L L + E+L S +V Q
Sbjct: 2319 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV----QM 2374
Query: 83 EAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAI 142
E + K I +N +L+ K N R E+ ++ A RL+
Sbjct: 2375 EELSKLKARIEAEN-----------RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2423
Query: 143 QEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEEL 202
+E ++ +L ++ R + +E+ +A E RL A ++ Q K+ A L
Sbjct: 2424 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2483
Query: 203 KTTKRKMNLKIQE----LRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
+ K +M ++ E +R L E+ + + A + L++ EM +
Sbjct: 2484 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2543
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
++ + + + + ++ + LEI Q D + I++L E + LQ
Sbjct: 2544 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ--- 2600
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E L SE+ Q + + + E + Q+ EK ++ + +
Sbjct: 2601 -----------QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEKDSLL-QRERFI 2646
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQ----- 433
+ E+ + Q FQ++ + Q ++ E+ +L A ++ ++ +
Sbjct: 2647 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2706
Query: 434 --KAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKE 475
+ Q E++ Q+ELL RLR +L+ ++ ++ L E
Sbjct: 2707 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2750
Score = 47.8 bits (112), Expect = 6e-05
Identities = 208/1085 (19%), Positives = 422/1085 (38%), Gaps = 186/1085 (17%)
Query: 166 AVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEK- 224
A+ E E + + E +RL +I ++ + A + EE+L + ++ L ++
Sbjct: 513 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA 572
Query: 225 -YLRESLEKSASAMLLKIQEMGSTVEVERKQ-------VHILQQNCIALR---------- 266
+ L+K+ S + L ++ + + Q V+ L + +A+R
Sbjct: 573 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG 632
Query: 267 ---DSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHE 323
+ Q AQ L Q +++ ELE +T + DL + VEEN++ ++ +
Sbjct: 633 VAAPATQVAQVTL-QSVQRRPELEDSTLRYLQDLLA-------WVEENQH-RVDGAEWGV 683
Query: 324 ENAYLRSEIMS---LHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQV 380
+ + +++ S LH++ E+ + ++ +LS + D L +
Sbjct: 684 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA-------YRDCLGRLDL 736
Query: 381 EQKMMTQTFQEQNLLLDAAH---ASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQD 437
+ + + + + L++ H A+ T EL + NEK + + D N +K
Sbjct: 737 QYAKLLNSSKARLRSLESLHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKK--- 792
Query: 438 AEKRTAVQK--ELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNL 495
E +A+ + EL E I L+ + ++E E FQ + ++Q C +
Sbjct: 793 -ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCI 851
Query: 496 EKELAKNKV------DINTLTHNLQTLEE--ENKHLADQMASL-ELQQVTSDYHGLAQQK 546
E L +N D+ LQ L+E K+ D+ A++ L+ + D AQ +
Sbjct: 852 EAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQD----AQDE 907
Query: 547 VEKITESKNKLA----YENGKLQIK-------------------VKQLEEQVQSFTDTSL 583
E++ E K L+ +Q+K KQ+E V + L
Sbjct: 908 KEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL 967
Query: 584 QNDHLRKMNKYLQTKYAQA------------NSELSAKRVHLQQADAHL--------KEV 623
K L + ++A N E L+ L ++
Sbjct: 968 VGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 1027
Query: 624 KSILE----RSKEELSRTVKCRNAALKESQKLKEDLEAVE------DRENKKVGNF---Q 670
KS+L R +L R+ + ++ ++ L ++E R+++ G F
Sbjct: 1028 KSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPED 1087
Query: 671 RQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQR-V 729
R +AE + +C + + +L S QGA E+ + + R SE+ ++ + + + R V
Sbjct: 1088 RLMAEREYGSC--SHHYQQLL--QSLEQGAQEESRCQ--RCISELKDIRLQLEACETRTV 1141
Query: 730 QKLEAEVDQWQAR----MLVMEDQHNSEIESLQKALGVAR---EDNRKLAM--------- 773
+L +D+ AR + + + +E+E L K GVAR E + LA+
Sbjct: 1142 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK--GVARLSAEAEKVLALPEPSPAAPT 1199
Query: 774 ----------SLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEA-- 821
LEQ + KL I + + + L ++++ E V A
Sbjct: 1200 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1259
Query: 822 -ELHAER--IEALRKQFQTERETTKKVAQ--REVAELKKALDEAN-FRSVEVSRTNRELR 875
EL A + ++ LR Q + ++ T + R E+ + L + + R VEV R +
Sbjct: 1260 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1319
Query: 876 QKLAELEKIL---ESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQ 932
Q L + +L + + +++ Q++ + + ++ ++ +++++ M L Q
Sbjct: 1320 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1379
Query: 933 YQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQEL-----HLE------A 981
++ Q ++ + +E Q AK QY ++++ + +L LE
Sbjct: 1380 AVREQLRQEQALLEEIERHGEKVEECQRFAK-QYINAIKDYELQLVTYKAQLEPVASPAK 1438
Query: 982 ERKIRQELENRCQELEETVRHLKKCKEATENTLKEAS-----VESEQITANLEEAHRWFK 1036
+ K++ E+ QE + H + T +K S +E E+ A + A +
Sbjct: 1439 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--R 1496
Query: 1037 HRFDGLQLELTKNR-LQRPSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQNLRPMPKKYH 1095
R ++ L K R L + + Q + + + + V+ R E + + +
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 1096 SEVQR 1100
E+Q+
Sbjct: 1557 EELQQ 1561
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 146 bits (369), Expect = 9e-35
Identities = 242/1122 (21%), Positives = 466/1122 (41%), Gaps = 179/1122 (15%)
Query: 26 SETFTVLQQRMRIVEEQTSSLRDDLIMLDFG-EKRGYLEAPDCLEDLDSQKVISPIQNEA 84
SET +++ R+ E+Q + R+ L ++ EK+ L +++ +Q
Sbjct: 1316 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1375
Query: 85 ICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQE 144
+ + + E V+ + S+ + L+ R +E ++ + A Q
Sbjct: 1376 -----QEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAK----------ARQA 1418
Query: 145 EHSKDLKL-LHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELK 203
E ++ +L + E+ +R QL A + + A+ E+Q L A + A K+ A E L+
Sbjct: 1419 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1478
Query: 204 T-----TKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
++RK +++ R A+ + RE + L++Q + + + +V
Sbjct: 1479 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1538
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
+Q +AL + +SA+ A+ Q K+ T+QL+ L +++L EE
Sbjct: 1539 RQVQVALETAQRSAE---AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA------- 1588
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E A ++E E +E+ L K L LQ + + + +A +A
Sbjct: 1589 ----ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1642
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDA 438
Q E+ E + + K + QA + E Q ++K +
Sbjct: 1643 QKEEA----------------------EREARRRGKAEEQAVRQRELAE--QELEKQRQL 1678
Query: 439 EKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKE 498
+ TA Q+ E + RLR E E Q+++ L EE R QRE Q+R LE E
Sbjct: 1679 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA----TQKRQELEAE 1734
Query: 499 LAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQ--KVEKITES--- 553
LAK + ++ L + EEE++ +++ + L+ + LA++ ++ + E
Sbjct: 1735 LAKVRAEMEVLLASKARAEEESRSTSEK-SKQRLEAEAGRFRELAEEAARLRALAEEAKR 1793
Query: 554 KNKLAYENGKLQI---------KVKQLEEQVQSFTDTSL-------QNDHLRKM------ 591
+ +LA E+ Q K+ + E + T+ + +N+ LR++
Sbjct: 1794 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1853
Query: 592 -NKYLQTKYAQANSELSAKRVHLQQA-DAHLKEVKSILE---RSKEELSRTVKCRNAALK 646
+ L+ + AQ +++ + L++A D+ L+ K ++E R + ++ + A+ +
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913
Query: 647 ESQKLKEDLE---------AVEDRENKKVGNF----QRQLAEAKE-------DNCKVTIM 686
++ K +LE A + +K+ QRQLA +E + + ++
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1973
Query: 687 LENVLASHSKMQGALEKVQ-----IELGRRDSEIAGLKKERDLN------QQR------- 728
E A K ALE+V+ +E RR E A + R L Q+R
Sbjct: 1974 AEEEAARQRK--AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2031
Query: 729 ----VQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE-----------------D 767
VQ+ E E+ Q + + DQ E E+ ++A A E +
Sbjct: 2032 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2091
Query: 768 NRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAER 827
+L S E+ Q Q + ++++ E + R E R + + E E H +
Sbjct: 2092 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2151
Query: 828 IE-ALRKQFQTERE-TTKKVAQREVAELKKALDEANFR----SVEVSRTNRELRQKLAEL 881
E LR++ Q E+E TT ++ E K LDE R + E +R ++ ++L +
Sbjct: 2152 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2211
Query: 882 EKILES-NKEKIKNQKTQIKLHLSAKANNA----QNIERMKQIEKELKQMELIKDQYQKK 936
+E +K K + + L L K N + E+MKQ+ +E ++ + + +
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271
Query: 937 NY--EQSLSIQRFVCEMTNLQKEMQMLAKS---QYDASVRNKQQELHLEAERKIRQELEN 991
E+ L+ QR + E L+++MQ + ++ + +A + +Q+EL E R+++++ E
Sbjct: 2272 RQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330
Query: 992 RCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHR 1033
Q+L E + ++ EA E S E+E++ + E R
Sbjct: 2331 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2372
Score = 141 bits (355), Expect = 4e-33
Identities = 214/985 (21%), Positives = 421/985 (42%), Gaps = 112/985 (11%)
Query: 138 RLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAI 197
RL A E+ + +LL E+ L+++ A ++ + + E+ ++ A +++ +K A
Sbjct: 1695 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-- 1752
Query: 198 IEEELKTT--KRKMNLKIQELR-RQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQ 254
EEE ++T K K L+ + R R+LA+E +L + A +E + E ++
Sbjct: 1753 -EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1811
Query: 255 VHILQQNCIALRDSIQSAQELLAQEQKKKEE---------------LEIATSQLKSDLTS 299
V + I +++ E+ +E++ + E LE +Q K+D+
Sbjct: 1812 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1871
Query: 300 RDDLISKLVEENKNLQISFNKEH-EENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSC 358
R + K + Q ++ + + EI++L + EKA +L + +
Sbjct: 1872 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1931
Query: 359 MLQTV--TMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQ 416
+ + E+A + A Q L E++ + +E+ AA + + E +
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 417 LQAHLDHLIL-------EHNQCIQKAQDA-EKRTAVQKELLESTIARLRGELEASMQEKK 468
L+A ++ E + +Q AQ+A +KR +++ + + EL+ ++Q+++
Sbjct: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2051
Query: 469 SLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMA 528
S+L++ + +E + R E+E A+++ + Q+ EE+ + A A
Sbjct: 2052 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111
Query: 529 SLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHL 588
+ E K+ K E + + + ++ KQ D ++ H
Sbjct: 2112 AAE--------------KLRKEAEQEAARRAQAEQAALRQKQA-------ADAEMEK-HK 2149
Query: 589 RKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKES 648
+ + L+ K AQ EL+ R+ L++ D + L+R K E + + R+ +E
Sbjct: 2150 KFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2208
Query: 649 QKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIEL 708
++ +E + + ++ R L +DN + + E + Q A E ++ +
Sbjct: 2209 FSVRVQMEELS-KLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVAEEAARLSV 2263
Query: 709 GRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQH-NSEIESLQKALGVARED 767
+++ E DL QQR + ++ QA V E +E E LQ+ +A+E
Sbjct: 2264 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA---VQEATRLKAEAELLQQQKELAQEQ 2320
Query: 768 NRKLAMSLEQALQ-----TNNHLQTKLDHIQEQLE-SKELERQNLETFK-DRMTEESKVE 820
R+L EQ Q T +T Q QLE S E ER L + R ++ +
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2380
Query: 821 AELHAERIEAL-RKQFQTERETTKKVAQREVAELKKALDEANFRSVE--VSRTNRELRQK 877
A+ ++ E + K +TE T +KV + E+++ + + + ++ RE ++K
Sbjct: 2381 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEK 2439
Query: 878 LAELEKILESNKEKIKN-------QKTQIKLHLSAKANNAQNIERMKQIEKELKQME-LI 929
L + K+L+ E+++ Q+TQ L S + ++R + IE+E ++E L
Sbjct: 2440 LQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
Query: 930 KDQYQKKNY---EQSLSIQRFVCEMTNLQKEMQMLAKSQYDAS--VRNKQQELH-LEAER 983
+D+ K EQ Q+ E L M+ + Q++A VR KQ+EL LE +R
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2558
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWF-------- 1035
+ ++EL L E + L++ + E + A SE++TA+ A +
Sbjct: 2559 RQQEEL------LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2612
Query: 1036 --------KHRFDGLQLELTKNRLQ 1052
+H FDGL+ +++ RLQ
Sbjct: 2613 GPAAEAEPEHSFDGLRRKVSAQRLQ 2637
Score = 132 bits (332), Expect = 2e-30
Identities = 217/1042 (20%), Positives = 433/1042 (41%), Gaps = 138/1042 (13%)
Query: 162 QQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMN--LKIQELRRQ 219
+++ A+ E A L TL Q + +AI E+LKT + +E+ R
Sbjct: 1026 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR- 1084
Query: 220 LAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQE 279
A E+ L+E+ ++ A L +++ ++++ R Q Q ALRD ++ AQE+ +
Sbjct: 1085 -AHEEQLKEA--QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1141
Query: 280 QKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEAS 339
Q++ E ++ + + + + ++ + Q + + Y R L
Sbjct: 1142 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1201
Query: 340 EKAQVLNDQL-TKKCSELSCMLQTVTMEKARI--IADH---------------QAILQVE 381
+ A+ +Q+ ++ + + + E+A + I H AI E
Sbjct: 1202 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1261
Query: 382 QKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKR 441
+++T Q + + A + + ++V E L+ H L +Q I+ + +R
Sbjct: 1262 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1321
Query: 442 TAVQKELLESTIARLR---GELEASMQEKKSLLEE---------------KERFQREVNK 483
++ L E A R E+EA++++++ L E ++R Q EV +
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 484 TEKEIV---QERCNLEKELAK----NKVDINTLTHNLQTLEEENKHLADQMASLELQ-QV 535
E+ V Q++ ++++EL + ++ +I + E + +++ + LQ +
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1441
Query: 536 TSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN---------- 585
T G A+ +++ + + + + Q + ++L QVQ + Q
Sbjct: 1442 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1501
Query: 586 ---------------DHLRKMNKYLQTKYAQANSELS------------AKRVHLQQADA 618
+ LR + + + QA E + + LQ A
Sbjct: 1502 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1561
Query: 619 HLKEVKSILERS-KEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAK 677
E + LERS +EE + R A + +Q+ E A E+ E +++ +Q + EA
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEA- 1619
Query: 678 EDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVD 737
++ + E V S Q EK Q E R++ G +E+ + Q+ + + E E
Sbjct: 1620 ---LRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1675
Query: 738 QW------QARMLVMED--QHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKL 789
+ Q R+ ++ + +E E ++ + E+ +L A Q L+ +L
Sbjct: 1676 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1735
Query: 790 DHIQEQLE--------SKELERQNLETFKDRMTEESKVEAEL--HAERIEALRKQFQTER 839
++ ++E ++E R E K R+ E+ EL A R+ AL ++ + +R
Sbjct: 1736 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795
Query: 840 ETTKKVAQREVAELKKALDEANFRSVEVSRTNRE----LRQKLAELEKILESNKEKIKNQ 895
+ ++ A R+ AE ++ L E E +R E L++K AE E++ +++ +
Sbjct: 1796 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1855
Query: 896 KTQIKLHLSAKANNAQNIERMKQIEK----EL-KQMELIKDQY-QKKNYEQSL-----SI 944
+ +L A + A ER+ Q+ K EL +Q L++D Q++ E+ + S
Sbjct: 1856 R---RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1912
Query: 945 QRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLK 1004
++ L+ E+ + + D +Q EL +R++ E E R +E EE V+
Sbjct: 1913 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1972
Query: 1005 KCKEATENTLKEASVESEQITANLEEAHRWFK--HRFDGLQLELTKNRLQ-RPSGEDR-- 1059
+E K A E E++ A +EEA R + + QL+L + Q R E++
Sbjct: 1973 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2032
Query: 1060 ---WQEKDQDVKHDVMSNQSVL 1078
Q+K+Q+++ + QSVL
Sbjct: 2033 AFAVQQKEQELQQTLQQEQSVL 2054
Score = 61.2 bits (147), Expect = 5e-09
Identities = 73/337 (21%), Positives = 145/337 (43%), Gaps = 42/337 (12%)
Query: 107 LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRA 166
L+ MQ+++ RL+ E +L Q+ +++ +QE+ + + L E ++ L A
Sbjct: 2290 LKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
Query: 167 VKEEEDKAQDEVQRLTATL-----------KIASQTKKNAAIIEEELKTTKRKMNLKI-- 213
++ + + E +RL + + A + +K A I E+L T+ K+
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2408
Query: 214 ---------------QELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVER--KQVH 256
+ LR +A+ + +E L++ A + LK +EM TV+ E+ ++
Sbjct: 2409 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQ 2467
Query: 257 ILQQNCIALRDSIQSAQELLAQEQKKKEEL---EIATSQLKSDLTSRDDLISKLVEENKN 313
LQQ+ ++ +DS+ + + QE+ K E+L E+A +Q + R ++ +E +
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ--QQMEQERQR 2525
Query: 314 LQISF----NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKAR 369
L S ++HE +R + L + ++ + + L ++ L LQ + E+ R
Sbjct: 2526 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHR 2584
Query: 370 IIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNE 406
H + Q T+T LD A E
Sbjct: 2585 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2621
Score = 57.4 bits (137), Expect = 7e-08
Identities = 86/464 (18%), Positives = 178/464 (38%), Gaps = 43/464 (9%)
Query: 23 ATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQN 82
A + T L+ ++ + Q + L ++L L + E+L S +V Q
Sbjct: 2160 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV----QM 2215
Query: 83 EAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAI 142
E + K I +N +L+ K N R E+ ++ A RL+
Sbjct: 2216 EELSKLKARIEAEN-----------RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2264
Query: 143 QEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEEL 202
+E ++ +L ++ R + +E+ +A E RL A ++ Q K+ A L
Sbjct: 2265 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2324
Query: 203 KTTKRKMNLKIQE----LRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
+ K +M ++ E +R L E+ + + A + L++ EM +
Sbjct: 2325 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2384
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
++ + + + + ++ + LEI Q D + I++L E + LQ
Sbjct: 2385 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ--- 2441
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E L SE+ Q + + + E + Q+ EK ++ + +
Sbjct: 2442 -----------QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEKDSLL-QRERFI 2487
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQ----- 433
+ E+ + Q FQ++ + Q ++ E+ +L A ++ ++ +
Sbjct: 2488 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2547
Query: 434 --KAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKE 475
+ Q E++ Q+ELL RLR +L+ ++ ++ L E
Sbjct: 2548 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2591
Score = 47.8 bits (112), Expect = 6e-05
Identities = 208/1085 (19%), Positives = 422/1085 (38%), Gaps = 186/1085 (17%)
Query: 166 AVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEK- 224
A+ E E + + E +RL +I ++ + A + EE+L + ++ L ++
Sbjct: 354 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA 413
Query: 225 -YLRESLEKSASAMLLKIQEMGSTVEVERKQ-------VHILQQNCIALR---------- 266
+ L+K+ S + L ++ + + Q V+ L + +A+R
Sbjct: 414 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG 473
Query: 267 ---DSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHE 323
+ Q AQ L Q +++ ELE +T + DL + VEEN++ ++ +
Sbjct: 474 VAAPATQVAQVTL-QSVQRRPELEDSTLRYLQDLLA-------WVEENQH-RVDGAEWGV 524
Query: 324 ENAYLRSEIMS---LHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQV 380
+ + +++ S LH++ E+ + ++ +LS + D L +
Sbjct: 525 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA-------YRDCLGRLDL 577
Query: 381 EQKMMTQTFQEQNLLLDAAH---ASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQD 437
+ + + + + L++ H A+ T EL + NEK + + D N +K
Sbjct: 578 QYAKLLNSSKARLRSLESLHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKK--- 633
Query: 438 AEKRTAVQK--ELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNL 495
E +A+ + EL E I L+ + ++E E FQ + ++Q C +
Sbjct: 634 -ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCI 692
Query: 496 EKELAKNKV------DINTLTHNLQTLEE--ENKHLADQMASL-ELQQVTSDYHGLAQQK 546
E L +N D+ LQ L+E K+ D+ A++ L+ + D AQ +
Sbjct: 693 EAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQD----AQDE 748
Query: 547 VEKITESKNKLA----YENGKLQIK-------------------VKQLEEQVQSFTDTSL 583
E++ E K L+ +Q+K KQ+E V + L
Sbjct: 749 KEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL 808
Query: 584 QNDHLRKMNKYLQTKYAQA------------NSELSAKRVHLQQADAHL--------KEV 623
K L + ++A N E L+ L ++
Sbjct: 809 VGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 868
Query: 624 KSILE----RSKEELSRTVKCRNAALKESQKLKEDLEAVE------DRENKKVGNF---Q 670
KS+L R +L R+ + ++ ++ L ++E R+++ G F
Sbjct: 869 KSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPED 928
Query: 671 RQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQR-V 729
R +AE + +C + + +L S QGA E+ + + R SE+ ++ + + + R V
Sbjct: 929 RLMAEREYGSC--SHHYQQLL--QSLEQGAQEESRCQ--RCISELKDIRLQLEACETRTV 982
Query: 730 QKLEAEVDQWQAR----MLVMEDQHNSEIESLQKALGVAR---EDNRKLAM--------- 773
+L +D+ AR + + + +E+E L K GVAR E + LA+
Sbjct: 983 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK--GVARLSAEAEKVLALPEPSPAAPT 1040
Query: 774 ----------SLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEA-- 821
LEQ + KL I + + + L ++++ E V A
Sbjct: 1041 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1100
Query: 822 -ELHAER--IEALRKQFQTERETTKKVAQ--REVAELKKALDEAN-FRSVEVSRTNRELR 875
EL A + ++ LR Q + ++ T + R E+ + L + + R VEV R +
Sbjct: 1101 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1160
Query: 876 QKLAELEKIL---ESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQ 932
Q L + +L + + +++ Q++ + + ++ ++ +++++ M L Q
Sbjct: 1161 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1220
Query: 933 YQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQEL-----HLE------A 981
++ Q ++ + +E Q AK QY ++++ + +L LE
Sbjct: 1221 AVREQLRQEQALLEEIERHGEKVEECQRFAK-QYINAIKDYELQLVTYKAQLEPVASPAK 1279
Query: 982 ERKIRQELENRCQELEETVRHLKKCKEATENTLKEAS-----VESEQITANLEEAHRWFK 1036
+ K++ E+ QE + H + T +K S +E E+ A + A +
Sbjct: 1280 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--R 1337
Query: 1037 HRFDGLQLELTKNR-LQRPSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQNLRPMPKKYH 1095
R ++ L K R L + + Q + + + + V+ R E + + +
Sbjct: 1338 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397
Query: 1096 SEVQR 1100
E+Q+
Sbjct: 1398 EELQQ 1402
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 146 bits (369), Expect = 9e-35
Identities = 242/1122 (21%), Positives = 466/1122 (41%), Gaps = 179/1122 (15%)
Query: 26 SETFTVLQQRMRIVEEQTSSLRDDLIMLDFG-EKRGYLEAPDCLEDLDSQKVISPIQNEA 84
SET +++ R+ E+Q + R+ L ++ EK+ L +++ +Q
Sbjct: 1324 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1383
Query: 85 ICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQE 144
+ + + E V+ + S+ + L+ R +E ++ + A Q
Sbjct: 1384 -----QEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAK----------ARQA 1426
Query: 145 EHSKDLKL-LHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELK 203
E ++ +L + E+ +R QL A + + A+ E+Q L A + A K+ A E L+
Sbjct: 1427 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1486
Query: 204 T-----TKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
++RK +++ R A+ + RE + L++Q + + + +V
Sbjct: 1487 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1546
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
+Q +AL + +SA+ A+ Q K+ T+QL+ L +++L EE
Sbjct: 1547 RQVQVALETAQRSAE---AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA------- 1596
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E A ++E E +E+ L K L LQ + + + +A +A
Sbjct: 1597 ----ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1650
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDA 438
Q E+ E + + K + QA + E Q ++K +
Sbjct: 1651 QKEEA----------------------EREARRRGKAEEQAVRQRELAE--QELEKQRQL 1686
Query: 439 EKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKE 498
+ TA Q+ E + RLR E E Q+++ L EE R QRE Q+R LE E
Sbjct: 1687 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA----TQKRQELEAE 1742
Query: 499 LAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQ--KVEKITES--- 553
LAK + ++ L + EEE++ +++ + L+ + LA++ ++ + E
Sbjct: 1743 LAKVRAEMEVLLASKARAEEESRSTSEK-SKQRLEAEAGRFRELAEEAARLRALAEEAKR 1801
Query: 554 KNKLAYENGKLQI---------KVKQLEEQVQSFTDTSL-------QNDHLRKM------ 591
+ +LA E+ Q K+ + E + T+ + +N+ LR++
Sbjct: 1802 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1861
Query: 592 -NKYLQTKYAQANSELSAKRVHLQQA-DAHLKEVKSILE---RSKEELSRTVKCRNAALK 646
+ L+ + AQ +++ + L++A D+ L+ K ++E R + ++ + A+ +
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921
Query: 647 ESQKLKEDLE---------AVEDRENKKVGNF----QRQLAEAKE-------DNCKVTIM 686
++ K +LE A + +K+ QRQLA +E + + ++
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1981
Query: 687 LENVLASHSKMQGALEKVQ-----IELGRRDSEIAGLKKERDLN------QQR------- 728
E A K ALE+V+ +E RR E A + R L Q+R
Sbjct: 1982 AEEEAARQRK--AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2039
Query: 729 ----VQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE-----------------D 767
VQ+ E E+ Q + + DQ E E+ ++A A E +
Sbjct: 2040 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2099
Query: 768 NRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAER 827
+L S E+ Q Q + ++++ E + R E R + + E E H +
Sbjct: 2100 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2159
Query: 828 IE-ALRKQFQTERE-TTKKVAQREVAELKKALDEANFR----SVEVSRTNRELRQKLAEL 881
E LR++ Q E+E TT ++ E K LDE R + E +R ++ ++L +
Sbjct: 2160 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2219
Query: 882 EKILES-NKEKIKNQKTQIKLHLSAKANNA----QNIERMKQIEKELKQMELIKDQYQKK 936
+E +K K + + L L K N + E+MKQ+ +E ++ + + +
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279
Query: 937 NY--EQSLSIQRFVCEMTNLQKEMQMLAKS---QYDASVRNKQQELHLEAERKIRQELEN 991
E+ L+ QR + E L+++MQ + ++ + +A + +Q+EL E R+++++ E
Sbjct: 2280 RQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338
Query: 992 RCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHR 1033
Q+L E + ++ EA E S E+E++ + E R
Sbjct: 2339 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2380
Score = 141 bits (355), Expect = 4e-33
Identities = 214/985 (21%), Positives = 421/985 (42%), Gaps = 112/985 (11%)
Query: 138 RLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAI 197
RL A E+ + +LL E+ L+++ A ++ + + E+ ++ A +++ +K A
Sbjct: 1703 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-- 1760
Query: 198 IEEELKTT--KRKMNLKIQELR-RQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQ 254
EEE ++T K K L+ + R R+LA+E +L + A +E + E ++
Sbjct: 1761 -EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1819
Query: 255 VHILQQNCIALRDSIQSAQELLAQEQKKKEE---------------LEIATSQLKSDLTS 299
V + I +++ E+ +E++ + E LE +Q K+D+
Sbjct: 1820 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1879
Query: 300 RDDLISKLVEENKNLQISFNKEH-EENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSC 358
R + K + Q ++ + + EI++L + EKA +L + +
Sbjct: 1880 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1939
Query: 359 MLQTV--TMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQ 416
+ + E+A + A Q L E++ + +E+ AA + + E +
Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Query: 417 LQAHLDHLIL-------EHNQCIQKAQDA-EKRTAVQKELLESTIARLRGELEASMQEKK 468
L+A ++ E + +Q AQ+A +KR +++ + + EL+ ++Q+++
Sbjct: 2000 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2059
Query: 469 SLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMA 528
S+L++ + +E + R E+E A+++ + Q+ EE+ + A A
Sbjct: 2060 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2119
Query: 529 SLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHL 588
+ E K+ K E + + + ++ KQ D ++ H
Sbjct: 2120 AAE--------------KLRKEAEQEAARRAQAEQAALRQKQA-------ADAEMEK-HK 2157
Query: 589 RKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKES 648
+ + L+ K AQ EL+ R+ L++ D + L+R K E + + R+ +E
Sbjct: 2158 KFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2216
Query: 649 QKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIEL 708
++ +E + + ++ R L +DN + + E + Q A E ++ +
Sbjct: 2217 FSVRVQMEELS-KLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVAEEAARLSV 2271
Query: 709 GRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQH-NSEIESLQKALGVARED 767
+++ E DL QQR + ++ QA V E +E E LQ+ +A+E
Sbjct: 2272 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA---VQEATRLKAEAELLQQQKELAQEQ 2328
Query: 768 NRKLAMSLEQALQ-----TNNHLQTKLDHIQEQLE-SKELERQNLETFK-DRMTEESKVE 820
R+L EQ Q T +T Q QLE S E ER L + R ++ +
Sbjct: 2329 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2388
Query: 821 AELHAERIEAL-RKQFQTERETTKKVAQREVAELKKALDEANFRSVE--VSRTNRELRQK 877
A+ ++ E + K +TE T +KV + E+++ + + + ++ RE ++K
Sbjct: 2389 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEK 2447
Query: 878 LAELEKILESNKEKIKN-------QKTQIKLHLSAKANNAQNIERMKQIEKELKQME-LI 929
L + K+L+ E+++ Q+TQ L S + ++R + IE+E ++E L
Sbjct: 2448 LQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2506
Query: 930 KDQYQKKNY---EQSLSIQRFVCEMTNLQKEMQMLAKSQYDAS--VRNKQQELH-LEAER 983
+D+ K EQ Q+ E L M+ + Q++A VR KQ+EL LE +R
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2566
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWF-------- 1035
+ ++EL L E + L++ + E + A SE++TA+ A +
Sbjct: 2567 RQQEEL------LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2620
Query: 1036 --------KHRFDGLQLELTKNRLQ 1052
+H FDGL+ +++ RLQ
Sbjct: 2621 GPAAEAEPEHSFDGLRRKVSAQRLQ 2645
Score = 132 bits (332), Expect = 2e-30
Identities = 217/1042 (20%), Positives = 433/1042 (41%), Gaps = 138/1042 (13%)
Query: 162 QQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMN--LKIQELRRQ 219
+++ A+ E A L TL Q + +AI E+LKT + +E+ R
Sbjct: 1034 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR- 1092
Query: 220 LAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQE 279
A E+ L+E+ ++ A L +++ ++++ R Q Q ALRD ++ AQE+ +
Sbjct: 1093 -AHEEQLKEA--QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1149
Query: 280 QKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEAS 339
Q++ E ++ + + + + ++ + Q + + Y R L
Sbjct: 1150 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1209
Query: 340 EKAQVLNDQL-TKKCSELSCMLQTVTMEKARI--IADH---------------QAILQVE 381
+ A+ +Q+ ++ + + + E+A + I H AI E
Sbjct: 1210 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1269
Query: 382 QKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKR 441
+++T Q + + A + + ++V E L+ H L +Q I+ + +R
Sbjct: 1270 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1329
Query: 442 TAVQKELLESTIARLR---GELEASMQEKKSLLEE---------------KERFQREVNK 483
++ L E A R E+EA++++++ L E ++R Q EV +
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 484 TEKEIV---QERCNLEKELAK----NKVDINTLTHNLQTLEEENKHLADQMASLELQ-QV 535
E+ V Q++ ++++EL + ++ +I + E + +++ + LQ +
Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1449
Query: 536 TSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN---------- 585
T G A+ +++ + + + + Q + ++L QVQ + Q
Sbjct: 1450 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1509
Query: 586 ---------------DHLRKMNKYLQTKYAQANSELS------------AKRVHLQQADA 618
+ LR + + + QA E + + LQ A
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1569
Query: 619 HLKEVKSILERS-KEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAK 677
E + LERS +EE + R A + +Q+ E A E+ E +++ +Q + EA
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEA- 1627
Query: 678 EDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVD 737
++ + E V S Q EK Q E R++ G +E+ + Q+ + + E E
Sbjct: 1628 ---LRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1683
Query: 738 QW------QARMLVMED--QHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKL 789
+ Q R+ ++ + +E E ++ + E+ +L A Q L+ +L
Sbjct: 1684 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1743
Query: 790 DHIQEQLE--------SKELERQNLETFKDRMTEESKVEAEL--HAERIEALRKQFQTER 839
++ ++E ++E R E K R+ E+ EL A R+ AL ++ + +R
Sbjct: 1744 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1803
Query: 840 ETTKKVAQREVAELKKALDEANFRSVEVSRTNRE----LRQKLAELEKILESNKEKIKNQ 895
+ ++ A R+ AE ++ L E E +R E L++K AE E++ +++ +
Sbjct: 1804 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1863
Query: 896 KTQIKLHLSAKANNAQNIERMKQIEK----EL-KQMELIKDQY-QKKNYEQSL-----SI 944
+ +L A + A ER+ Q+ K EL +Q L++D Q++ E+ + S
Sbjct: 1864 R---RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1920
Query: 945 QRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLK 1004
++ L+ E+ + + D +Q EL +R++ E E R +E EE V+
Sbjct: 1921 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1980
Query: 1005 KCKEATENTLKEASVESEQITANLEEAHRWFK--HRFDGLQLELTKNRLQ-RPSGEDR-- 1059
+E K A E E++ A +EEA R + + QL+L + Q R E++
Sbjct: 1981 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2040
Query: 1060 ---WQEKDQDVKHDVMSNQSVL 1078
Q+K+Q+++ + QSVL
Sbjct: 2041 AFAVQQKEQELQQTLQQEQSVL 2062
Score = 61.2 bits (147), Expect = 5e-09
Identities = 73/337 (21%), Positives = 145/337 (43%), Gaps = 42/337 (12%)
Query: 107 LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRA 166
L+ MQ+++ RL+ E +L Q+ +++ +QE+ + + L E ++ L A
Sbjct: 2298 LKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356
Query: 167 VKEEEDKAQDEVQRLTATL-----------KIASQTKKNAAIIEEELKTTKRKMNLKI-- 213
++ + + E +RL + + A + +K A I E+L T+ K+
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2416
Query: 214 ---------------QELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVER--KQVH 256
+ LR +A+ + +E L++ A + LK +EM TV+ E+ ++
Sbjct: 2417 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQ 2475
Query: 257 ILQQNCIALRDSIQSAQELLAQEQKKKEEL---EIATSQLKSDLTSRDDLISKLVEENKN 313
LQQ+ ++ +DS+ + + QE+ K E+L E+A +Q + R ++ +E +
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ--QQMEQERQR 2533
Query: 314 LQISF----NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKAR 369
L S ++HE +R + L + ++ + + L ++ L LQ + E+ R
Sbjct: 2534 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHR 2592
Query: 370 IIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNE 406
H + Q T+T LD A E
Sbjct: 2593 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2629
Score = 57.4 bits (137), Expect = 7e-08
Identities = 86/464 (18%), Positives = 178/464 (38%), Gaps = 43/464 (9%)
Query: 23 ATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQN 82
A + T L+ ++ + Q + L ++L L + E+L S +V Q
Sbjct: 2168 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV----QM 2223
Query: 83 EAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAI 142
E + K I +N +L+ K N R E+ ++ A RL+
Sbjct: 2224 EELSKLKARIEAEN-----------RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2272
Query: 143 QEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEEL 202
+E ++ +L ++ R + +E+ +A E RL A ++ Q K+ A L
Sbjct: 2273 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2332
Query: 203 KTTKRKMNLKIQE----LRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
+ K +M ++ E +R L E+ + + A + L++ EM +
Sbjct: 2333 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2392
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
++ + + + + ++ + LEI Q D + I++L E + LQ
Sbjct: 2393 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ--- 2449
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E L SE+ Q + + + E + Q+ EK ++ + +
Sbjct: 2450 -----------QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEKDSLL-QRERFI 2495
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQ----- 433
+ E+ + Q FQ++ + Q ++ E+ +L A ++ ++ +
Sbjct: 2496 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2555
Query: 434 --KAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKE 475
+ Q E++ Q+ELL RLR +L+ ++ ++ L E
Sbjct: 2556 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2599
Score = 47.8 bits (112), Expect = 6e-05
Identities = 208/1085 (19%), Positives = 422/1085 (38%), Gaps = 186/1085 (17%)
Query: 166 AVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEK- 224
A+ E E + + E +RL +I ++ + A + EE+L + ++ L ++
Sbjct: 362 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA 421
Query: 225 -YLRESLEKSASAMLLKIQEMGSTVEVERKQ-------VHILQQNCIALR---------- 266
+ L+K+ S + L ++ + + Q V+ L + +A+R
Sbjct: 422 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG 481
Query: 267 ---DSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHE 323
+ Q AQ L Q +++ ELE +T + DL + VEEN++ ++ +
Sbjct: 482 VAAPATQVAQVTL-QSVQRRPELEDSTLRYLQDLLA-------WVEENQH-RVDGAEWGV 532
Query: 324 ENAYLRSEIMS---LHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQV 380
+ + +++ S LH++ E+ + ++ +LS + D L +
Sbjct: 533 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA-------YRDCLGRLDL 585
Query: 381 EQKMMTQTFQEQNLLLDAAH---ASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQD 437
+ + + + + L++ H A+ T EL + NEK + + D N +K
Sbjct: 586 QYAKLLNSSKARLRSLESLHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKK--- 641
Query: 438 AEKRTAVQK--ELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNL 495
E +A+ + EL E I L+ + ++E E FQ + ++Q C +
Sbjct: 642 -ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCI 700
Query: 496 EKELAKNKV------DINTLTHNLQTLEE--ENKHLADQMASL-ELQQVTSDYHGLAQQK 546
E L +N D+ LQ L+E K+ D+ A++ L+ + D AQ +
Sbjct: 701 EAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQD----AQDE 756
Query: 547 VEKITESKNKLA----YENGKLQIK-------------------VKQLEEQVQSFTDTSL 583
E++ E K L+ +Q+K KQ+E V + L
Sbjct: 757 KEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL 816
Query: 584 QNDHLRKMNKYLQTKYAQA------------NSELSAKRVHLQQADAHL--------KEV 623
K L + ++A N E L+ L ++
Sbjct: 817 VGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 876
Query: 624 KSILE----RSKEELSRTVKCRNAALKESQKLKEDLEAVE------DRENKKVGNF---Q 670
KS+L R +L R+ + ++ ++ L ++E R+++ G F
Sbjct: 877 KSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPED 936
Query: 671 RQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQR-V 729
R +AE + +C + + +L S QGA E+ + + R SE+ ++ + + + R V
Sbjct: 937 RLMAEREYGSC--SHHYQQLL--QSLEQGAQEESRCQ--RCISELKDIRLQLEACETRTV 990
Query: 730 QKLEAEVDQWQAR----MLVMEDQHNSEIESLQKALGVAR---EDNRKLAM--------- 773
+L +D+ AR + + + +E+E L K GVAR E + LA+
Sbjct: 991 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK--GVARLSAEAEKVLALPEPSPAAPT 1048
Query: 774 ----------SLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEA-- 821
LEQ + KL I + + + L ++++ E V A
Sbjct: 1049 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1108
Query: 822 -ELHAER--IEALRKQFQTERETTKKVAQ--REVAELKKALDEAN-FRSVEVSRTNRELR 875
EL A + ++ LR Q + ++ T + R E+ + L + + R VEV R +
Sbjct: 1109 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1168
Query: 876 QKLAELEKIL---ESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQ 932
Q L + +L + + +++ Q++ + + ++ ++ +++++ M L Q
Sbjct: 1169 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1228
Query: 933 YQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQEL-----HLE------A 981
++ Q ++ + +E Q AK QY ++++ + +L LE
Sbjct: 1229 AVREQLRQEQALLEEIERHGEKVEECQRFAK-QYINAIKDYELQLVTYKAQLEPVASPAK 1287
Query: 982 ERKIRQELENRCQELEETVRHLKKCKEATENTLKEAS-----VESEQITANLEEAHRWFK 1036
+ K++ E+ QE + H + T +K S +E E+ A + A +
Sbjct: 1288 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--R 1345
Query: 1037 HRFDGLQLELTKNR-LQRPSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQNLRPMPKKYH 1095
R ++ L K R L + + Q + + + + V+ R E + + +
Sbjct: 1346 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405
Query: 1096 SEVQR 1100
E+Q+
Sbjct: 1406 EELQQ 1410
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 146 bits (369), Expect = 9e-35
Identities = 242/1122 (21%), Positives = 466/1122 (41%), Gaps = 179/1122 (15%)
Query: 26 SETFTVLQQRMRIVEEQTSSLRDDLIMLDFG-EKRGYLEAPDCLEDLDSQKVISPIQNEA 84
SET +++ R+ E+Q + R+ L ++ EK+ L +++ +Q
Sbjct: 1365 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424
Query: 85 ICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQE 144
+ + + E V+ + S+ + L+ R +E ++ + A Q
Sbjct: 1425 -----QEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAK----------ARQA 1467
Query: 145 EHSKDLKL-LHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELK 203
E ++ +L + E+ +R QL A + + A+ E+Q L A + A K+ A E L+
Sbjct: 1468 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1527
Query: 204 T-----TKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
++RK +++ R A+ + RE + L++Q + + + +V
Sbjct: 1528 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1587
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
+Q +AL + +SA+ A+ Q K+ T+QL+ L +++L EE
Sbjct: 1588 RQVQVALETAQRSAE---AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA------- 1637
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E A ++E E +E+ L K L LQ + + + +A +A
Sbjct: 1638 ----ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1691
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDA 438
Q E+ E + + K + QA + E Q ++K +
Sbjct: 1692 QKEEA----------------------EREARRRGKAEEQAVRQRELAE--QELEKQRQL 1727
Query: 439 EKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKE 498
+ TA Q+ E + RLR E E Q+++ L EE R QRE Q+R LE E
Sbjct: 1728 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA----TQKRQELEAE 1783
Query: 499 LAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQ--KVEKITES--- 553
LAK + ++ L + EEE++ +++ + L+ + LA++ ++ + E
Sbjct: 1784 LAKVRAEMEVLLASKARAEEESRSTSEK-SKQRLEAEAGRFRELAEEAARLRALAEEAKR 1842
Query: 554 KNKLAYENGKLQI---------KVKQLEEQVQSFTDTSL-------QNDHLRKM------ 591
+ +LA E+ Q K+ + E + T+ + +N+ LR++
Sbjct: 1843 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1902
Query: 592 -NKYLQTKYAQANSELSAKRVHLQQA-DAHLKEVKSILE---RSKEELSRTVKCRNAALK 646
+ L+ + AQ +++ + L++A D+ L+ K ++E R + ++ + A+ +
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1962
Query: 647 ESQKLKEDLE---------AVEDRENKKVGNF----QRQLAEAKE-------DNCKVTIM 686
++ K +LE A + +K+ QRQLA +E + + ++
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2022
Query: 687 LENVLASHSKMQGALEKVQ-----IELGRRDSEIAGLKKERDLN------QQR------- 728
E A K ALE+V+ +E RR E A + R L Q+R
Sbjct: 2023 AEEEAARQRK--AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2080
Query: 729 ----VQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVARE-----------------D 767
VQ+ E E+ Q + + DQ E E+ ++A A E +
Sbjct: 2081 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2140
Query: 768 NRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAER 827
+L S E+ Q Q + ++++ E + R E R + + E E H +
Sbjct: 2141 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2200
Query: 828 IE-ALRKQFQTERE-TTKKVAQREVAELKKALDEANFR----SVEVSRTNRELRQKLAEL 881
E LR++ Q E+E TT ++ E K LDE R + E +R ++ ++L +
Sbjct: 2201 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2260
Query: 882 EKILES-NKEKIKNQKTQIKLHLSAKANNA----QNIERMKQIEKELKQMELIKDQYQKK 936
+E +K K + + L L K N + E+MKQ+ +E ++ + + +
Sbjct: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320
Query: 937 NY--EQSLSIQRFVCEMTNLQKEMQMLAKS---QYDASVRNKQQELHLEAERKIRQELEN 991
E+ L+ QR + E L+++MQ + ++ + +A + +Q+EL E R+++++ E
Sbjct: 2321 RQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379
Query: 992 RCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHR 1033
Q+L E + ++ EA E S E+E++ + E R
Sbjct: 2380 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2421
Score = 141 bits (355), Expect = 4e-33
Identities = 214/985 (21%), Positives = 421/985 (42%), Gaps = 112/985 (11%)
Query: 138 RLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAI 197
RL A E+ + +LL E+ L+++ A ++ + + E+ ++ A +++ +K A
Sbjct: 1744 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-- 1801
Query: 198 IEEELKTT--KRKMNLKIQELR-RQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQ 254
EEE ++T K K L+ + R R+LA+E +L + A +E + E ++
Sbjct: 1802 -EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1860
Query: 255 VHILQQNCIALRDSIQSAQELLAQEQKKKEE---------------LEIATSQLKSDLTS 299
V + I +++ E+ +E++ + E LE +Q K+D+
Sbjct: 1861 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1920
Query: 300 RDDLISKLVEENKNLQISFNKEH-EENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSC 358
R + K + Q ++ + + EI++L + EKA +L + +
Sbjct: 1921 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1980
Query: 359 MLQTV--TMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQ 416
+ + E+A + A Q L E++ + +E+ AA + + E +
Sbjct: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
Query: 417 LQAHLDHLIL-------EHNQCIQKAQDA-EKRTAVQKELLESTIARLRGELEASMQEKK 468
L+A ++ E + +Q AQ+A +KR +++ + + EL+ ++Q+++
Sbjct: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2100
Query: 469 SLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMA 528
S+L++ + +E + R E+E A+++ + Q+ EE+ + A A
Sbjct: 2101 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2160
Query: 529 SLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHL 588
+ E K+ K E + + + ++ KQ D ++ H
Sbjct: 2161 AAE--------------KLRKEAEQEAARRAQAEQAALRQKQA-------ADAEMEK-HK 2198
Query: 589 RKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKES 648
+ + L+ K AQ EL+ R+ L++ D + L+R K E + + R+ +E
Sbjct: 2199 KFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2257
Query: 649 QKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIEL 708
++ +E + + ++ R L +DN + + E + Q A E ++ +
Sbjct: 2258 FSVRVQMEELS-KLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVAEEAARLSV 2312
Query: 709 GRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQH-NSEIESLQKALGVARED 767
+++ E DL QQR + ++ QA V E +E E LQ+ +A+E
Sbjct: 2313 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA---VQEATRLKAEAELLQQQKELAQEQ 2369
Query: 768 NRKLAMSLEQALQ-----TNNHLQTKLDHIQEQLE-SKELERQNLETFK-DRMTEESKVE 820
R+L EQ Q T +T Q QLE S E ER L + R ++ +
Sbjct: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2429
Query: 821 AELHAERIEAL-RKQFQTERETTKKVAQREVAELKKALDEANFRSVE--VSRTNRELRQK 877
A+ ++ E + K +TE T +KV + E+++ + + + ++ RE ++K
Sbjct: 2430 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEK 2488
Query: 878 LAELEKILESNKEKIKN-------QKTQIKLHLSAKANNAQNIERMKQIEKELKQME-LI 929
L + K+L+ E+++ Q+TQ L S + ++R + IE+E ++E L
Sbjct: 2489 LQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
Query: 930 KDQYQKKNY---EQSLSIQRFVCEMTNLQKEMQMLAKSQYDAS--VRNKQQELH-LEAER 983
+D+ K EQ Q+ E L M+ + Q++A VR KQ+EL LE +R
Sbjct: 2548 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2607
Query: 984 KIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWF-------- 1035
+ ++EL L E + L++ + E + A SE++TA+ A +
Sbjct: 2608 RQQEEL------LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2661
Query: 1036 --------KHRFDGLQLELTKNRLQ 1052
+H FDGL+ +++ RLQ
Sbjct: 2662 GPAAEAEPEHSFDGLRRKVSAQRLQ 2686
Score = 132 bits (332), Expect = 2e-30
Identities = 217/1042 (20%), Positives = 433/1042 (41%), Gaps = 138/1042 (13%)
Query: 162 QQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMN--LKIQELRRQ 219
+++ A+ E A L TL Q + +AI E+LKT + +E+ R
Sbjct: 1075 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR- 1133
Query: 220 LAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQE 279
A E+ L+E+ ++ A L +++ ++++ R Q Q ALRD ++ AQE+ +
Sbjct: 1134 -AHEEQLKEA--QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1190
Query: 280 QKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEAS 339
Q++ E ++ + + + + ++ + Q + + Y R L
Sbjct: 1191 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1250
Query: 340 EKAQVLNDQL-TKKCSELSCMLQTVTMEKARI--IADH---------------QAILQVE 381
+ A+ +Q+ ++ + + + E+A + I H AI E
Sbjct: 1251 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1310
Query: 382 QKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKR 441
+++T Q + + A + + ++V E L+ H L +Q I+ + +R
Sbjct: 1311 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1370
Query: 442 TAVQKELLESTIARLR---GELEASMQEKKSLLEE---------------KERFQREVNK 483
++ L E A R E+EA++++++ L E ++R Q EV +
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 484 TEKEIV---QERCNLEKELAK----NKVDINTLTHNLQTLEEENKHLADQMASLELQ-QV 535
E+ V Q++ ++++EL + ++ +I + E + +++ + LQ +
Sbjct: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1490
Query: 536 TSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQN---------- 585
T G A+ +++ + + + + Q + ++L QVQ + Q
Sbjct: 1491 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1550
Query: 586 ---------------DHLRKMNKYLQTKYAQANSELS------------AKRVHLQQADA 618
+ LR + + + QA E + + LQ A
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1610
Query: 619 HLKEVKSILERS-KEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAK 677
E + LERS +EE + R A + +Q+ E A E+ E +++ +Q + EA
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEA- 1668
Query: 678 EDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVD 737
++ + E V S Q EK Q E R++ G +E+ + Q+ + + E E
Sbjct: 1669 ---LRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1724
Query: 738 QW------QARMLVMED--QHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKL 789
+ Q R+ ++ + +E E ++ + E+ +L A Q L+ +L
Sbjct: 1725 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1784
Query: 790 DHIQEQLE--------SKELERQNLETFKDRMTEESKVEAEL--HAERIEALRKQFQTER 839
++ ++E ++E R E K R+ E+ EL A R+ AL ++ + +R
Sbjct: 1785 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844
Query: 840 ETTKKVAQREVAELKKALDEANFRSVEVSRTNRE----LRQKLAELEKILESNKEKIKNQ 895
+ ++ A R+ AE ++ L E E +R E L++K AE E++ +++ +
Sbjct: 1845 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1904
Query: 896 KTQIKLHLSAKANNAQNIERMKQIEK----EL-KQMELIKDQY-QKKNYEQSL-----SI 944
+ +L A + A ER+ Q+ K EL +Q L++D Q++ E+ + S
Sbjct: 1905 R---RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1961
Query: 945 QRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLK 1004
++ L+ E+ + + D +Q EL +R++ E E R +E EE V+
Sbjct: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2021
Query: 1005 KCKEATENTLKEASVESEQITANLEEAHRWFK--HRFDGLQLELTKNRLQ-RPSGEDR-- 1059
+E K A E E++ A +EEA R + + QL+L + Q R E++
Sbjct: 2022 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2081
Query: 1060 ---WQEKDQDVKHDVMSNQSVL 1078
Q+K+Q+++ + QSVL
Sbjct: 2082 AFAVQQKEQELQQTLQQEQSVL 2103
Score = 61.2 bits (147), Expect = 5e-09
Identities = 73/337 (21%), Positives = 145/337 (43%), Gaps = 42/337 (12%)
Query: 107 LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRA 166
L+ MQ+++ RL+ E +L Q+ +++ +QE+ + + L E ++ L A
Sbjct: 2339 LKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
Query: 167 VKEEEDKAQDEVQRLTATL-----------KIASQTKKNAAIIEEELKTTKRKMNLKI-- 213
++ + + E +RL + + A + +K A I E+L T+ K+
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2457
Query: 214 ---------------QELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVER--KQVH 256
+ LR +A+ + +E L++ A + LK +EM TV+ E+ ++
Sbjct: 2458 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQ 2516
Query: 257 ILQQNCIALRDSIQSAQELLAQEQKKKEEL---EIATSQLKSDLTSRDDLISKLVEENKN 313
LQQ+ ++ +DS+ + + QE+ K E+L E+A +Q + R ++ +E +
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ--QQMEQERQR 2574
Query: 314 LQISF----NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKAR 369
L S ++HE +R + L + ++ + + L ++ L LQ + E+ R
Sbjct: 2575 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHR 2633
Query: 370 IIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNE 406
H + Q T+T LD A E
Sbjct: 2634 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2670
Score = 57.4 bits (137), Expect = 7e-08
Identities = 86/464 (18%), Positives = 178/464 (38%), Gaps = 43/464 (9%)
Query: 23 ATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQN 82
A + T L+ ++ + Q + L ++L L + E+L S +V Q
Sbjct: 2209 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV----QM 2264
Query: 83 EAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAI 142
E + K I +N +L+ K N R E+ ++ A RL+
Sbjct: 2265 EELSKLKARIEAEN-----------RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2313
Query: 143 QEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEEL 202
+E ++ +L ++ R + +E+ +A E RL A ++ Q K+ A L
Sbjct: 2314 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2373
Query: 203 KTTKRKMNLKIQE----LRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHIL 258
+ K +M ++ E +R L E+ + + A + L++ EM +
Sbjct: 2374 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2433
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
++ + + + + ++ + LEI Q D + I++L E + LQ
Sbjct: 2434 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ--- 2490
Query: 319 NKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL 378
E L SE+ Q + + + E + Q+ EK ++ + +
Sbjct: 2491 -----------QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEKDSLL-QRERFI 2536
Query: 379 QVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQ----- 433
+ E+ + Q FQ++ + Q ++ E+ +L A ++ ++ +
Sbjct: 2537 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2596
Query: 434 --KAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKE 475
+ Q E++ Q+ELL RLR +L+ ++ ++ L E
Sbjct: 2597 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2640
Score = 47.8 bits (112), Expect = 6e-05
Identities = 208/1085 (19%), Positives = 422/1085 (38%), Gaps = 186/1085 (17%)
Query: 166 AVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEK- 224
A+ E E + + E +RL +I ++ + A + EE+L + ++ L ++
Sbjct: 403 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA 462
Query: 225 -YLRESLEKSASAMLLKIQEMGSTVEVERKQ-------VHILQQNCIALR---------- 266
+ L+K+ S + L ++ + + Q V+ L + +A+R
Sbjct: 463 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG 522
Query: 267 ---DSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHE 323
+ Q AQ L Q +++ ELE +T + DL + VEEN++ ++ +
Sbjct: 523 VAAPATQVAQVTL-QSVQRRPELEDSTLRYLQDLLA-------WVEENQH-RVDGAEWGV 573
Query: 324 ENAYLRSEIMS---LHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQV 380
+ + +++ S LH++ E+ + ++ +LS + D L +
Sbjct: 574 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA-------YRDCLGRLDL 626
Query: 381 EQKMMTQTFQEQNLLLDAAH---ASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQD 437
+ + + + + L++ H A+ T EL + NEK + + D N +K
Sbjct: 627 QYAKLLNSSKARLRSLESLHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKK--- 682
Query: 438 AEKRTAVQK--ELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNL 495
E +A+ + EL E I L+ + ++E E FQ + ++Q C +
Sbjct: 683 -ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCI 741
Query: 496 EKELAKNKV------DINTLTHNLQTLEE--ENKHLADQMASL-ELQQVTSDYHGLAQQK 546
E L +N D+ LQ L+E K+ D+ A++ L+ + D AQ +
Sbjct: 742 EAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQD----AQDE 797
Query: 547 VEKITESKNKLA----YENGKLQIK-------------------VKQLEEQVQSFTDTSL 583
E++ E K L+ +Q+K KQ+E V + L
Sbjct: 798 KEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL 857
Query: 584 QNDHLRKMNKYLQTKYAQA------------NSELSAKRVHLQQADAHL--------KEV 623
K L + ++A N E L+ L ++
Sbjct: 858 VGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 917
Query: 624 KSILE----RSKEELSRTVKCRNAALKESQKLKEDLEAVE------DRENKKVGNF---Q 670
KS+L R +L R+ + ++ ++ L ++E R+++ G F
Sbjct: 918 KSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPED 977
Query: 671 RQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQR-V 729
R +AE + +C + + +L S QGA E+ + + R SE+ ++ + + + R V
Sbjct: 978 RLMAEREYGSC--SHHYQQLL--QSLEQGAQEESRCQ--RCISELKDIRLQLEACETRTV 1031
Query: 730 QKLEAEVDQWQAR----MLVMEDQHNSEIESLQKALGVAR---EDNRKLAM--------- 773
+L +D+ AR + + + +E+E L K GVAR E + LA+
Sbjct: 1032 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK--GVARLSAEAEKVLALPEPSPAAPT 1089
Query: 774 ----------SLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEA-- 821
LEQ + KL I + + + L ++++ E V A
Sbjct: 1090 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1149
Query: 822 -ELHAER--IEALRKQFQTERETTKKVAQ--REVAELKKALDEAN-FRSVEVSRTNRELR 875
EL A + ++ LR Q + ++ T + R E+ + L + + R VEV R +
Sbjct: 1150 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1209
Query: 876 QKLAELEKIL---ESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQ 932
Q L + +L + + +++ Q++ + + ++ ++ +++++ M L Q
Sbjct: 1210 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1269
Query: 933 YQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQEL-----HLE------A 981
++ Q ++ + +E Q AK QY ++++ + +L LE
Sbjct: 1270 AVREQLRQEQALLEEIERHGEKVEECQRFAK-QYINAIKDYELQLVTYKAQLEPVASPAK 1328
Query: 982 ERKIRQELENRCQELEETVRHLKKCKEATENTLKEAS-----VESEQITANLEEAHRWFK 1036
+ K++ E+ QE + H + T +K S +E E+ A + A +
Sbjct: 1329 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--R 1386
Query: 1037 HRFDGLQLELTKNR-LQRPSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQNLRPMPKKYH 1095
R ++ L K R L + + Q + + + + V+ R E + + +
Sbjct: 1387 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446
Query: 1096 SEVQR 1100
E+Q+
Sbjct: 1447 EELQQ 1451
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 145 bits (365), Expect = 3e-34
Identities = 231/1086 (21%), Positives = 459/1086 (42%), Gaps = 135/1086 (12%)
Query: 33 QQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQNEAICAGKTDI 92
Q+ + VEEQ L I L+ K E + E+++S+ + E C
Sbjct: 907 QETLANVEEQCEWLIKSKIQLEARVKE-LSERVEEEEEINSELTARGRKLEDECFE---- 961
Query: 93 LWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKL 152
L K + L + + E ++ + + L E + + + L +QE H + L
Sbjct: 962 LKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDD 1021
Query: 153 LHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLK 212
LH+E ++L ++ + K + +V L L+ Q +K E EL + + L
Sbjct: 1022 LHME----EEKLSSLSKANLKLEQQVDELEGALE---QERKARMNCERELHKLEGNLKLN 1074
Query: 213 IQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSA 272
+ + + +++L E L K L++ +M S VE E+ V LQ+ L+ I+
Sbjct: 1075 RESMENLESSQRHLAEELRKKE----LELSQMNSKVENEKGLVAQLQKTVKELQTQIKDL 1130
Query: 273 QELLAQEQKKKEELEIATSQLKSDLTSRDDLISKL-------VEENKNLQISFNKEHE-- 323
+E L E+ + ++E + L DL ++ + ++ +E K + F K H
Sbjct: 1131 KEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDM 1190
Query: 324 ENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAIL-QVEQ 382
E A L E S A L +L + L + Q + +K+ + + +L +VEQ
Sbjct: 1191 EEATLHFETTSASLKKRHADSL-AELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQ 1249
Query: 383 KMMTQTFQEQ--NLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAE- 439
+ E+ L + H + T +L V L A L E + +++ ++ E
Sbjct: 1250 MTRAKANAEKLCTLYEERLHEA-TAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEA 1308
Query: 440 --KRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQE---RCN 494
+ + +K I LRG+LE + + +L ++ QR+ + ++ +E +
Sbjct: 1309 LINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAE 1368
Query: 495 LEKELAKNKVDI--------NTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQK 546
L + L+K ++ N + + LE+ K LA ++ Q ++ G+A +
Sbjct: 1369 LHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRL------QEAAEAMGVANAR 1422
Query: 547 VEKITESKNKLAYE------------------------NGKLQIKVKQLEEQVQSFTDTS 582
+ ++++L E +GK KQ E+ Q+ D S
Sbjct: 1423 NASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDAS 1482
Query: 583 ------LQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSR 636
L + L+ N Y ++ Q L + +LQ+ ++L ++ E+ +
Sbjct: 1483 QKEVQALSTELLKLKNTYEESIVGQ--ETLRRENKNLQEEISNLTNQVREGTKNLTEMEK 1540
Query: 637 TVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAK-EDNCKVTIMLENVLASHS 695
K E Q E+ E +R K+ +FQ +L EAK E K++ E +
Sbjct: 1541 VKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRR 1600
Query: 696 KMQGALEKVQIEL---GRRDSEIAGLKK--ERDLNQQRVQKLEAEVDQWQARMLVMEDQH 750
K Q ++ +Q L + E+ LKK E DLN+ +Q A +A + Q
Sbjct: 1601 KQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSL--GQL 1658
Query: 751 NSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFK 810
+I+ LQ L + + N L + A + N+ LQ++L+ ++ E E R
Sbjct: 1659 QIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGR------- 1711
Query: 811 DRMTEESKVEAELHAERIE----------ALRKQFQTERETTKKVAQREVAELKKALDEA 860
R++EE +EA ERI + +K+ + + +K A+ V E + A ++A
Sbjct: 1712 -RLSEEELLEA---TERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKA 1767
Query: 861 NFRSVEVSRTNRELRQK---LAELEKILESNKEKIKNQKTQI----KLHLSAKANNAQNI 913
++E + + EL++K +A LE+ E+ ++ I + + ++ ++ L Q +
Sbjct: 1768 KKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKL 1827
Query: 914 E-RMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMT--------NLQKEMQMLAKS 964
E R++++E EL + E+ + ++ + ++R + E+T NL + + K
Sbjct: 1828 ESRVRELEGEL-EGEIRRSAEAQRGARR---LERCIKELTYQAEEDKKNLSRMQTQMDKL 1883
Query: 965 QYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQI 1024
Q V+N +Q++ + AE + Q L ++ ++ + + +K+ E E+ + + +++ +
Sbjct: 1884 Q--LKVQNYKQQVEV-AETQANQYL-SKYKKQQHELNEVKERAEVAESQVNKLKIKAREF 1939
Query: 1025 TANLEE 1030
++E
Sbjct: 1940 GKKVQE 1945
Score = 132 bits (333), Expect = 1e-30
Identities = 207/986 (20%), Positives = 416/986 (42%), Gaps = 123/986 (12%)
Query: 130 QKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIAS 189
+K+ F ++ L A Q +++ L L++ ++ L V+E+ + +L A +K S
Sbjct: 876 EKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELS 935
Query: 190 QTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVE 249
+ + I EL RK+ + EL++++ + + EK K++ + VE
Sbjct: 936 ERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVE 995
Query: 250 VERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVE 309
+ + L + ++++ Q + L E++K L A +L+ + D+L L +
Sbjct: 996 FLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQV---DELEGALEQ 1052
Query: 310 ENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKAR 369
E K + H+ L+ S+ + L ++L KK ELS M V EK
Sbjct: 1053 ERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGL 1112
Query: 370 I-------------IADHQAILQVEQ----KM------MTQTFQEQNLLLDAAHASITNE 406
+ I D + L+ E+ KM +TQ + N L+ S +
Sbjct: 1113 VAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQ 1172
Query: 407 LQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQE 466
L+ + ++T+ Q H + E +A K+ ++A L G++E Q
Sbjct: 1173 LEITKKQETKFQK-------LHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQV 1225
Query: 467 KKSLLEEKERFQREVN---KTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHL 523
K+ L ++K Q EV+ +++ + + N EK L TL EE H
Sbjct: 1226 KQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEK---------------LCTLYEERLH- 1269
Query: 524 ADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSL 583
A+ +L +VT + LA Q K KL E+G+ +++LEE+ S
Sbjct: 1270 ---EATAKLDKVTQLANDLAAQ--------KTKLWSESGEF---LRRLEEKEALINQLSR 1315
Query: 584 QNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAH---LKEVKSILERSKEELSRTVKC 640
+ + + + L+ + + SA LQ+A L+E + K EL RT+
Sbjct: 1316 EKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSK 1375
Query: 641 RNAALKESQKLKED--LEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQ 698
NA + + + E+ ++ ED E+ K +L EA E + A ++ ++
Sbjct: 1376 VNAEMVQWRMKYENNVIQRTEDLEDAK-KELAIRLQEAAE-------AMGVANARNASLE 1427
Query: 699 GALEKVQIELGRRDSEIAGLKK-ERDLNQQRVQKLEAEVD--QWQARMLVMEDQHNSEIE 755
A ++Q+ELG S++ ++ L+Q+++Q +A D Q + D E++
Sbjct: 1428 RARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQ 1487
Query: 756 SLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTE 815
+L L + + + E + N +LQ ++ ++ Q+ +E K ++ E
Sbjct: 1488 ALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVK-KLIE 1546
Query: 816 ESKVEAELHAE----------------RIEALRKQFQTERETTKKVAQRE---------V 850
E K E ++ E ++E L + + ER+ ++K + E +
Sbjct: 1547 EEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTI 1606
Query: 851 AELKKALDEANFRSVEVSRTNRELRQKLAELEKILE-SNKEKIKNQKTQIKLHLSAKANN 909
L+ +LD +EV+R +++ + L E+E L +N++ + K+ +L + K
Sbjct: 1607 DSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQ 1666
Query: 910 AQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEM--QMLAKSQYD 967
Q ++ Q+ +LK+ + ++ + + L R + E T + + + L ++
Sbjct: 1667 MQ-LDDSTQLNSDLKEQVAVAER-RNSLLQSELEDLRSLQEQTERGRRLSEEELLEATER 1724
Query: 968 ASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITAN 1027
++ Q L ++K+ ++ +E EE V ++C+ A E K+A++E+ ++
Sbjct: 1725 INLFYTQNTSLLSQKKKLEADVARMQKEAEEVV---QECQNAEEKA-KKAAIEAANLSEE 1780
Query: 1028 LEEAHRWFKHRFDGLQLELTKNRLQR 1053
L++ H LE T+ +++
Sbjct: 1781 LKKKQDTIAH------LERTRENMEQ 1800
Score = 94.7 bits (234), Expect = 4e-19
Identities = 143/671 (21%), Positives = 289/671 (43%), Gaps = 92/671 (13%)
Query: 98 EFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTA------------FLKDRLNAIQE- 144
E L+N++ R +S + ++ R Q EK+ Q L+++ QE
Sbjct: 1307 EALINQLSREKSNF-TRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEV 1365
Query: 145 --EHSKDLKLLHLEVMNLRQQLRA-VKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEE 201
E + L ++ E++ R + V + + +D + L L+ A++ A
Sbjct: 1366 KAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNAS 1425
Query: 202 LKTTKRKMNLKIQELRRQLAQEKYLRESLE-------KSASAMLLKIQEMGSTVEVERKQ 254
L+ + ++ L++ + L + + L+ K+ + K +E + ++ +K+
Sbjct: 1426 LERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKE 1485
Query: 255 VHILQQNCIALRDSIQSA---QELLAQEQKK-KEELEIATSQLKSDLTSRDDL--ISKLV 308
V L + L+++ + + QE L +E K +EE+ T+Q++ + ++ + KL+
Sbjct: 1486 VQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLI 1545
Query: 309 EENKNLQISFNKEHEENAYLRSEIMSLH---EASEKAQVLNDQLTKKCSELSCML--QTV 363
EE K ++ E E A R+E LH E E L +L++K E+ Q
Sbjct: 1546 EEEKT-EVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQC 1604
Query: 364 TMEKARIIADHQAILQVE----QKMMTQTFQEQNLLLDAAHASI---TNELQTVQNEKTQ 416
T++ + D +A ++E +K M + E L L A+ + T L +Q +
Sbjct: 1605 TIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKD 1664
Query: 417 LQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIA---------RLRGE--LEASMQ 465
LQ LD ++ ++ AE+R ++ + LE + RL E LEA+ +
Sbjct: 1665 LQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATER 1724
Query: 466 ------EKKSLLEEKERFQREVNKTEKE---IVQERCNLEKELAKNKVDINTLTHNLQTL 516
+ SLL +K++ + +V + +KE +VQE N E++ K ++ L+ L+
Sbjct: 1725 INLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKK 1784
Query: 517 EEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQ 576
++ HL ++E Q +T LA+ + + S+ ++ KL+ +V++LE +++
Sbjct: 1785 QDTIAHLERTRENME-QTITDLQKRLAEAEQMALMGSRKQIQ----KLESRVRELEGELE 1839
Query: 577 SFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSR 636
+R+ A ++ A+R+ + +KE+ E K+ LSR
Sbjct: 1840 G---------EIRR----------SAEAQRGARRL-----ERCIKELTYQAEEDKKNLSR 1875
Query: 637 TVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSK 696
+ + Q K+ +E E + N+ + +++Q E E + + V K
Sbjct: 1876 MQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIK 1935
Query: 697 MQGALEKVQIE 707
+ +KVQ E
Sbjct: 1936 AREFGKKVQEE 1946
Score = 70.5 bits (171), Expect = 8e-12
Identities = 68/357 (19%), Positives = 164/357 (45%), Gaps = 27/357 (7%)
Query: 714 EIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAM 773
E+AGLK+E Q+ ++K E + ++ +A+ + + + N I LQ +E +
Sbjct: 860 EVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQ----AEQETLANVEE 915
Query: 774 SLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRK 833
E +++ L+ ++ + E++E +E L T + R E+ E + + +E +
Sbjct: 916 QCEWLIKSKIQLEARVKELSERVEEEEEINSEL-TARGRKLEDECFELKKEIDDLETMLV 974
Query: 834 QFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIK 893
+ + E+ TT+ ++K +E F + ++S+ NR + + E++++ +
Sbjct: 975 KSEKEKRTTEH-------KVKNLTEEVEFLNEDISKLNRAAK-------VVQEAHQQTLD 1020
Query: 894 NQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTN 953
+ + + S N + +++ ++E L+Q + +++ ++ +++ M N
Sbjct: 1021 DLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMEN 1080
Query: 954 LQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENT 1013
L+ + LA+ + Q +E E+ + +L+ +EL+ ++ LK+ EA T
Sbjct: 1081 LESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTT 1140
Query: 1014 LKEASVESEQITANLEEAHRWFKHRFDG--LQLELTKNRLQRPSGEDRWQEKDQDVK 1068
+ E +T +L + + + QLE+TK + E ++Q+ +D++
Sbjct: 1141 RAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQ------ETKFQKLHRDME 1191
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 145 bits (365), Expect = 3e-34
Identities = 217/991 (21%), Positives = 425/991 (42%), Gaps = 123/991 (12%)
Query: 100 LVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQE-----EHSKDLKLLH 154
L ++ L+ +++ MN+ L+ L PQ F K+ N + E +K L
Sbjct: 224 LQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEE-NPESDGEPVVEDGTSVKTLE 282
Query: 155 LEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQ 214
+++Q +K ++ Q ++ T + S+ + ++E L+ ++ +L +
Sbjct: 283 TLQQRVKRQENLLKRCKETIQSHKEQCTL---LTSEKEALQEQLDERLQELEKIKDLHMA 339
Query: 215 E---LRRQLAQEKYLRESLEKSASAMLLKIQ-EMGSTVEVERKQVHILQQNCIALRDSIQ 270
E L QL K L E LE+ ++ + + +M T+E++ +++ L+ ++
Sbjct: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR---IKQMTT 396
Query: 271 SAQELLAQEQKKK----EELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENA 326
+EL Q++K + EELE A S + +R L +++ E+ K ++ EE
Sbjct: 397 QGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE---KTSEEERI 453
Query: 327 YLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMT 386
L+ E+ S Q + D + K E LQ + + + Q ++ +K+ T
Sbjct: 454 SLQQEL------SRVKQEVVDVMKKSSEEQIAKLQK--LHEKELARKEQ---ELTKKLQT 502
Query: 387 QTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQK 446
+ + Q + A S + L+ Q ++ Q L+ L L+ + ++++ + +
Sbjct: 503 REREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEA 562
Query: 447 ELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDI 506
E + I L LE S+QE K+ K++ +LE E K+ +I
Sbjct: 563 ETYRTRILELESSLEKSLQENKN--------------QSKDLA---VHLEAEKNKHNKEI 605
Query: 507 NTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYEN----- 561
+ +T E KH D + + +LQ + Y ++ EK + K L +
Sbjct: 606 TVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ 665
Query: 562 -----------GKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSA-- 608
KL +K +LE ++ L + L+ + + EL A
Sbjct: 666 AHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKM 725
Query: 609 ---KRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQK-LKEDLEAVEDRENK 664
K H QQ D+ +KE + ++R+++ L + LKE K LKE VE+ E
Sbjct: 726 DEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLE-- 783
Query: 665 KVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDL 724
+ +R E ++ + K+ + A+H + + E +L + ++ L+ ER L
Sbjct: 784 --ADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE----QLAQLQQKLLDLETERIL 837
Query: 725 NQQRVQKLEA-------EVD----QWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAM 773
++V ++EA E+D Q Q M +E Q NSE+E K+L E KL
Sbjct: 838 LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQ-NSEMEQKVKSLTQVYES--KLED 894
Query: 774 SLEQALQTNNHLQTKLDHIQEQLE--SKELE--RQNLETFKDR---MTEESKVEAELHAE 826
++ QT L K + I + E KE+E Q L +D + EE + + + +
Sbjct: 895 GNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK 954
Query: 827 RIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEK--- 883
++E ++++ + +ET KK + A+LKK L+ ++E+S+ ++ K+ E+ +
Sbjct: 955 KMEKVKQKAKEMQETLKKKLLDQEAKLKKELENT---ALELSQKEKQFNAKMLEMAQANS 1011
Query: 884 --ILESNKEKIKNQKTQIKLHLSAKANNAQNI-----ERMKQIEKELKQMELIKDQYQKK 936
I ++ NQK QI+ ++ +++ Q +EL+++ I+ Q +++
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 937 NY-EQSLSIQRFVCEMTNLQKEMQMLAKS--QYDASVRNKQQELHLEAERKIRQELENRC 993
E I F CE + KE+ L + + D ++ Q++L ++ + +
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL-----KQKSAHVNSLA 1126
Query: 994 QELEETVRHLKKCKEATENTLKEASVESEQI 1024
Q+ + HL+K + +LKE + EQ+
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQL 1157
Score = 134 bits (337), Expect = 5e-31
Identities = 213/1118 (19%), Positives = 472/1118 (42%), Gaps = 200/1118 (17%)
Query: 136 KDRLNAIQEEHSKDLK-LLHLEVMNLRQQLRAVKEEED----KAQDEVQRLTATLKIASQ 190
K+++ ++ E H ++L ++ + L QQ ++E + + + EV L + +
Sbjct: 1026 KEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGC 1085
Query: 191 TKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEV 250
K+ LK K + + EL+ QL Q+ SL + + + ++++ +
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNK 1145
Query: 251 ERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEE 310
K+ LQ+ + L+ +LA+E K+K + TS+LK+ L S +
Sbjct: 1146 SLKENTFLQEQLVELK--------MLAEEDKRK--VSELTSKLKTTDEEFQSLKSSHEKS 1195
Query: 311 NKNLQ---ISFNKEHEENAYL------RSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQ 361
NK+L+ + F K EE A ++E + + +E + + + S +S
Sbjct: 1196 NKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQH 1255
Query: 362 TVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHL 421
T K ++ + ++E ++ T +EQN L + + T++L+ +N+ ++A +
Sbjct: 1256 RTTKVKEALLIKTCTVSELEAQLRQLT-EEQNTL-NISFQQATHQLEEKENQIKSMKADI 1313
Query: 422 DHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREV 481
+ L+ E + +QK +++ A +KE S I +L+ EL ++ + EE + + E+
Sbjct: 1314 ESLVTE-KEALQKEGGNQQQAASEKE---SCITQLKKELSENINAVTLMKEELKEKKVEI 1369
Query: 482 NKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHG 541
+ K++ L+ ++ ++ + ++ + +EE L DQ+ L + T
Sbjct: 1370 SSLSKQLTDLNVQLQNSISLSEKEA-AISSLRKQYDEEKCELLDQVQDLSFKVDT----- 1423
Query: 542 LAQQKV---EKITESKNKLAYENGKLQIK-------VKQLEEQVQSFTDTSLQNDH---- 587
L+++K+ E++ + NK + K Q + VK+L+ Q++ + + + D
Sbjct: 1424 LSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483
Query: 588 ----LRKMNKY--------------LQTKYAQANSELSAKRVHLQQADAHLKEVKSILER 629
L + NK ++ K + +EL ++ + + + H+ + +E
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIES 1543
Query: 630 SKEELSRTVKCRNAALKES-QKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLE 688
E L + ++ KE QKL+ E E+++N+ + EA+E + +
Sbjct: 1544 LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR--------VKEAEEKILTLENQVY 1595
Query: 689 NVLASHSKMQGALEKVQIELGRRDSEIAGLK---------KERDLNQQRVQKLEAEVDQW 739
++ A + LE V + + ++ E+ L+ K +L ++ QK+ A Q
Sbjct: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
Query: 740 QARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKL-------DHI 792
++M E+Q+ ES L ++ + LE+ L++ Q++ ++
Sbjct: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715
Query: 793 QEQLESKELERQNL--ETFKDR-------MTEESKVEAELHAERIEALRKQFQTERETTK 843
E +E + Q +T++++ +TE+ K+ + E+ E + F+ + +
Sbjct: 1716 AAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE 1775
Query: 844 KVAQREVAE------------LKKALDEANFR---------SVEVSRTNRELRQKLA--- 879
++ + E AE L++ L+E N + E + N + +Q L
Sbjct: 1776 RLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVF 1835
Query: 880 -ELEKILESNK-------EKIKN-------QKTQIKLHLSAKANNAQNIERMKQIEKELK 924
+++K L+ + +KIK QK ++ + + + ++ ++Q++ K
Sbjct: 1836 DDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNK 1895
Query: 925 QMELIKDQYQKKNYEQSLSI------------------------QRFVCEMTNLQKEMQM 960
EL+++ ++K+ + Q+ E+ LQK+++M
Sbjct: 1896 PTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRM 1955
Query: 961 LAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKK--------CKEATEN 1012
L K ++ + ++E E E KI+QE E+ + T++ L + ++ E
Sbjct: 1956 LRK-EHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM 2014
Query: 1013 TLKEASVESEQITANLEEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDVKHDVM 1072
T+KE +++++ A L E+H+ E T L++ + EKD D+K
Sbjct: 2015 TIKETINKAQEVEAELLESHQ-----------EETNQLLKKIA------EKDDDLKRTAK 2057
Query: 1073 SNQSVLHRWERKQ---------NLRPMPKKYHSEVQRK 1101
+ +L E + L + KKY +++++
Sbjct: 2058 RYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQE 2095
Score = 130 bits (326), Expect = 9e-30
Identities = 206/963 (21%), Positives = 424/963 (44%), Gaps = 103/963 (10%)
Query: 103 RMCRLESLMQS-LKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLR 161
R+ +ESL +S +K ++FR +++ L + +RL+ S D ++ +
Sbjct: 68 RVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPS---DMDSEA 124
Query: 162 QQLRAVKEEEDKAQ--DEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMN-LKIQELRR 218
+ L + +K Q ++R+ +L + L+ K+K+ + Q +
Sbjct: 125 EDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDK 184
Query: 219 QLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQ----- 273
L + LRE L+ A +E +++E + + + +LQ L+ +++
Sbjct: 185 SLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDV 244
Query: 274 -------ELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENA 326
E A+ K+E E + D TS L + +++ Q + K +E
Sbjct: 245 LKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTL--ETLQQRVKRQENLLKRCKETI 302
Query: 327 YLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMT 386
E +L + ++A L +QL ++ EL + EK ++I L+ + ++
Sbjct: 303 QSHKEQCTLLTSEKEA--LQEQLDERLQELEKIKDLHMAEKTKLITQ----LRDAKNLIE 356
Query: 387 QTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQK 446
Q Q++ +++ + L+ + E QL++ + + + + ++ + +E+ +
Sbjct: 357 QLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL 416
Query: 447 ELLESTIAR---LRGELEASMQE-----KKSLLEEKERFQREVNKTEKEIV--------Q 490
E ST + R +L+A M E +K+ EE+ Q+E+++ ++E+V +
Sbjct: 417 EKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE 476
Query: 491 ERCNL----EKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQK 546
+ L EKELA+ + + LT LQT E E +QM + L++ S+Y ++Q+K
Sbjct: 477 QIAKLQKLHEKELARKEQE---LTKKLQTRERE---FQEQM-KVALEKSQSEYLKISQEK 529
Query: 547 VEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLR----KMNKYLQTKYAQA 602
E + LA E +LQ K L E D + + R ++ L+ +
Sbjct: 530 -----EQQESLALEELELQ-KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQEN 583
Query: 603 NSELSAKRVHLQ-QADAHLKEVKSILERSKEELSRTVKCRNAALKES-QKLKEDLEAVED 660
++ VHL+ + + H KE+ ++E+ K EL ++A E Q LK+ + +
Sbjct: 584 KNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEME 643
Query: 661 RENKKVGNFQRQLAEAKE--DNCKVTIMLENVLASHSKMQGALEKVQIELG-------RR 711
+ +K + L + KE + M E L Q LE + EL +
Sbjct: 644 KLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKL 703
Query: 712 DSEIAGLKKERDLNQQRVQ-KLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRK 770
+ E++ LK + D +Q ++ K++ + + Q ++ + +H I+ +KAL ++ +
Sbjct: 704 EEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKAL---KDQINQ 760
Query: 771 LAMSLEQALQTNNHLQTKLDHIQEQLESKELERQN-------LETFKDRMTEESKVEAEL 823
L + L++ + Q +++++ ++ E E Q ++++ E++K E
Sbjct: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
Query: 824 HAERIEALRKQFQTER-ETTKKVAQREVAELKKALDEANFRSVEV-------SRTNRELR 875
A+ + L +TER TK+VA+ E A+ K E + ++V + N E+
Sbjct: 821 LAQLQQKL-LDLETERILLTKQVAEVE-AQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
Query: 876 QKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQK 935
QK+ L ++ ES E ++ Q K L K N I +M++ +K K++E++ +
Sbjct: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN---MILQMREGQK--KEIEILTQKLSA 933
Query: 936 KNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQE 995
K + + + + N +K+M+ + + + K++ L EA K+++ELEN E
Sbjct: 934 KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEA--KLKKELENTALE 991
Query: 996 LEE 998
L +
Sbjct: 992 LSQ 994
Score = 123 bits (309), Expect = 8e-28
Identities = 238/1180 (20%), Positives = 469/1180 (39%), Gaps = 218/1180 (18%)
Query: 25 ASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQNEA 84
AS V Q EQT + + L L L DL++++++ Q
Sbjct: 796 ASAKLDVFQSYQSATHEQTKAYEEQLAQLQ-----------QKLLDLETERILLTKQVAE 844
Query: 85 ICAGKTDILWKNCEFLVNRMCRLESLMQSL-KMNIFRLQTEKDLNP-------------- 129
+ A K D+ C L +++ LMQ L K N Q K L
Sbjct: 845 VEAQKKDV----CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
Query: 130 QKTAFLKDRLNAI---QEEHSKDLKLLHLEVMNLRQQLRAVKEE-EDKAQDEVQRLTATL 185
Q L ++ N I +E K++++L ++ + + EE E K +++ +++
Sbjct: 901 QTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKME--- 957
Query: 186 KIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQ-EKYLRESLEKSASAMLLKIQEM 244
K+ + K+ ++++L + K+ +++ +L+Q EK + + A A I +
Sbjct: 958 KVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDA 1017
Query: 245 GSTVEVERKQ----------------VHILQQNCIALRDSIQSAQELLAQEQKK------ 282
S +E +K+ + I ++ + +Q E+ QE+++
Sbjct: 1018 VSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELK 1077
Query: 283 ---------KEELEIATSQLKSDLTSRDDLISKLVEENKN-------------------- 313
KEE+ + LK + +D +++L E+ K
Sbjct: 1078 QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE 1137
Query: 314 -LQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIA 372
L++ NK +EN +L+ +++ L ++L ++ +K SEL+ L+T E + +
Sbjct: 1138 KLEVDLNKSLKENTFLQEQLVEL-------KMLAEEDKRKVSELTSKLKTTDEEFQSLKS 1190
Query: 373 DHQ-AILQVEQKMMTQTFQEQNLLL---------DAAHASITNELQTVQNEKTQLQAHLD 422
H+ + +E K + + L + +A + TNEL + + KT
Sbjct: 1191 SHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKT------- 1243
Query: 423 HLILEHNQCIQKAQDAEKRTAVQKELL---ESTIARLRGELEASMQEKKSLLEEKERFQR 479
N + + + RT KE L T++ L +L +E+ +L FQ+
Sbjct: 1244 ------NAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL---NISFQQ 1294
Query: 480 EVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDY 539
++ E++ E ++ K DI +L + L++E + QQ S+
Sbjct: 1295 ATHQLEEK--------ENQIKSMKADIESLVTEKEALQKEGGN---------QQQAASEK 1337
Query: 540 HGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKY 599
Q ++++E+ N + +L+ K ++ + TD ++Q
Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ--------------- 1382
Query: 600 AQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVE 659
Q + LS K + E K L ++LS V + KE E ++
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKV---DTLSKEKISALEQVDDWS 1439
Query: 660 DRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLK 719
++ ++ Q + + + ++ I LE + + ++ EL +++ LK
Sbjct: 1440 NKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499
Query: 720 KERDLNQQRVQK----LEAEVDQWQARMLVMED---QHNSEIESLQKALGVAREDNRKLA 772
E + ++ +++K LE E+ AR++ +ED Q EIESL + L +
Sbjct: 1500 GEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH 1559
Query: 773 MSLEQALQTNNHLQTKLDHIQEQLESKELERQN--------LETFKDRMTEESKVEAELH 824
L Q LQ L + D+ ++ E K L +N LET K + E + +
Sbjct: 1560 KELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET-KKKELEHVNLSVKSK 1618
Query: 825 AERIEALRKQFQTERET----TKKVAQREVAELKKAL------DEANFRSVEVSRTNREL 874
E ++AL + ++E K+ A++++A +KK L E ++ S + EL
Sbjct: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLS-EL 1677
Query: 875 RQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQ 934
KL E E+ + +EK+K+ + S+++ K + +Q E
Sbjct: 1678 NTKLQEREREVHILEEKLKSVE-------SSQSETLIVPRSAKNVAAYTEQEEADSQGCV 1730
Query: 935 KKNYEQSLSI-QRFVCE----MTNLQKEMQMLAKSQYDASVRNKQQELHLE-AERKIRQE 988
+K YE+ +S+ QR + E + + +E + S ++ + +++ + LE AE K ++
Sbjct: 1731 QKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHED 1790
Query: 989 ---LENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFDGLQLE 1045
+ + +ELEE ++ K ++ KE + Q NLE FD +Q
Sbjct: 1791 QSMIGHLQEELEE--KNKKYSLIVAQHVEKEGGKNNIQAKQNLENV-------FDDVQKT 1841
Query: 1046 LTKNRLQRPSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQ 1085
L + L E + +E D + Q +HR E ++
Sbjct: 1842 LQEKELTCQILEQKIKELD-----SCLVRQKEVHRVEMEE 1876
Score = 109 bits (272), Expect = 2e-23
Identities = 197/943 (20%), Positives = 391/943 (41%), Gaps = 125/943 (13%)
Query: 126 DLNPQKTAFLKDRLNAIQEEHSKDLKLLHLE---VMNLRQQLRAVKEEEDKAQDEVQRLT 182
+++ KT + R++ Q +K + L ++ V L QLR + EE++ Q+ T
Sbjct: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
Query: 183 ATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEK-----YLRESLEKSASAM 237
L+ K+ E L T K + K ++Q A EK L++ L ++ +A+
Sbjct: 1297 HQLEEKENQIKSMKADIESLVTEKEALQ-KEGGNQQQAASEKESCITQLKKELSENINAV 1355
Query: 238 LLKIQEMG------STVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEEL--EIA 289
L +E+ S++ + +++ QN I+L + + L Q ++K EL ++
Sbjct: 1356 TLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ 1415
Query: 290 TSQLKSDLTSR---------DDLISKLVEENKNLQISF----NKEHEENAYLRSEIMSLH 336
K D S+ DD +K E K Q F N E L + +
Sbjct: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
Query: 337 EASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLL 396
E E+ +L ++L ++ C+ + +K+++ ++ L+ E K T E +
Sbjct: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM-EKKESNLETELKSQTARIMELEDHI 1534
Query: 397 DAAHASITNELQTVQNEKTQLQAHLDHLI--LEHNQCIQKAQDAEKRTAVQKEL-LESTI 453
I + + ++N Q L+ L+H Q + + +D + A +K L LE+ +
Sbjct: 1535 TQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQV 1594
Query: 454 ARLRGELEASMQEKK--------------------------SLLEEKERFQREVNKTEKE 487
++ ELE +E + L E K + ++++ +K+
Sbjct: 1595 YSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQ 1654
Query: 488 IVQERCNLEKELAKN-KVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQK 546
++ + E++ K + ++ L LQ E E L +++ S+E Q + + +
Sbjct: 1655 LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKN 1714
Query: 547 VEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQ---------- 596
V TE + A G +Q K EE++ S+ +L + K LQ
Sbjct: 1715 VAAYTEQEE--ADSQGCVQ---KTYEEKI------SVLQRNLTEKEKLLQRVGQEKEETV 1763
Query: 597 TKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALK---ESQKLKE 653
+ + + + + + L+ A+A E +S++ +EEL K + + E + K
Sbjct: 1764 SSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKN 1823
Query: 654 DLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDS 713
+++A ++ EN + Q+ L E KE C++ L S Q + +V++E
Sbjct: 1824 NIQAKQNLENV-FDDVQKTLQE-KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKY 1881
Query: 714 EIAGLKKERDLNQQRVQKLEAEVDQWQARMLV-------MEDQHNSEIESLQKALGVARE 766
E ++ D + + LE ++ LV ME QHN L+ L A
Sbjct: 1882 EKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHND----LEFKLAGAER 1937
Query: 767 DNRKLAMSLEQALQTNNHLQTKLDHIQE-QLESKELERQNLETFKDRMTEESKVEAELHA 825
+ +KL + + LQ + + K +H QE ++ KE +++ E K E+ +E + H
Sbjct: 1938 EKQKLGKEIVR-LQKDLRMLRK-EHQQELEILKKEYDQEREEKIKQ---EQEDLELK-HN 1991
Query: 826 ERIEALRKQFQTE------------RETTKKVAQREVAELKKALDEANFRSVEVSRTNRE 873
++ L ++F T+ +ET K + E L+ +E N +++ + +
Sbjct: 1992 STLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDD 2051
Query: 874 LRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEK----ELKQMELI 929
L++ E+IL++ +E++ + ++ L Q ++++Q E + MEL
Sbjct: 2052 LKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQ--QKLEQEENPGNDNVTIMELQ 2109
Query: 930 KDQYQKKNY--EQSLSIQRFVCEMTNLQKEMQMLAKSQYDASV 970
QK + L Q F ++ NL+ ++ K+ Y +V
Sbjct: 2110 TQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTV 2152
Score = 69.7 bits (169), Expect = 1e-11
Identities = 141/694 (20%), Positives = 294/694 (42%), Gaps = 60/694 (8%)
Query: 408 QTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEK 467
Q + E+ QLQ L N + + ++ ++L E T R G+ ++ Q+
Sbjct: 7 QKISEEQQQLQQALAPAQASSNSSTPTRMRS-RTSSFTEQLDEGTPNRESGDTQSFAQKL 65
Query: 468 KSLLEEKERFQREVNKTEKEIVQERCNLEKELAK---NKVDINTLTHNLQT---LEEENK 521
+ + E R K + +L + ++ N++D+++ T + ++ E +
Sbjct: 66 QLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAE 125
Query: 522 HLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDT 581
L SL +Q+ + ++ + ++L LQ + K+L+ + D
Sbjct: 126 DLVGNSDSLNKEQLIQRLRRM-ERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDK 184
Query: 582 SLQNDHLRKMNKYLQTKYAQANSELSAK-RVHLQQADAHLKEVKSILERSKEELSRTVKC 640
SL+ + ++ + LQ QA L + L++ D ++ +++ + K+ L R
Sbjct: 185 SLRR--IAELREELQMDQ-QAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL-RNGPM 240
Query: 641 RNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGA 700
LK +L+ E EN + ED V LE + + +
Sbjct: 241 NVDVLKPLPQLEPQAEVFTKEENPESDG-----EPVVEDGTSVKT-LETLQQRVKRQENL 294
Query: 701 LEKVQIELGRRDSEIAGLKKERDLNQQ----RVQKLEAEVDQWQA---RMLVMEDQHNSE 753
L++ + + + L E++ Q+ R+Q+LE D A +++ +
Sbjct: 295 LKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNL 354
Query: 754 IESLQKALG-VAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDR 812
IE L++ G V E R++ +LE + L++++ + Q E +++ E
Sbjct: 355 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFE 414
Query: 813 MTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNR 872
E++ A+ E L+ + + +T +K ++ E L++ L V+V + +
Sbjct: 415 ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS 474
Query: 873 ELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQ 932
E +++A+L+K+ E +++ ++ ++ L + Q E+MK + E Q E +K
Sbjct: 475 E--EQIAKLQKLHE---KELARKEQELTKKLQTREREFQ--EQMK-VALEKSQSEYLKIS 526
Query: 933 YQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAER------KIR 986
Q+K ++SL+++ LQK+ +L +S+ NK ++L EAE ++
Sbjct: 527 -QEKEQQESLALEEL-----ELQKKA-ILTESE------NKLRDLQQEAETYRTRILELE 573
Query: 987 QELENRCQELEETVRHLKKCKEATENT-LKEASVESEQITANLEEAHRWFKHRFDGLQLE 1045
LE QE + + L EA +N KE +V E+ LE KH+ D L E
Sbjct: 574 SSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELES----LKHQQDALWTE 629
Query: 1046 -LTKNRLQRPSGEDRWQEKDQDVKHDVMSNQSVL 1078
L + Q + ++ +EK + K ++ ++ ++
Sbjct: 630 KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEII 663
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 144 bits (362), Expect = 6e-34
Identities = 233/1091 (21%), Positives = 457/1091 (41%), Gaps = 174/1091 (15%)
Query: 13 RPVLSPTHINATASETFTVLQ-----QRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDC 67
R L TH++ T + LQ + EE+ L + L+ G+ + E +
Sbjct: 919 RQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLE-GKVKELSERLED 977
Query: 68 LEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDL 127
E++++ + E C L K+ + L + + E Q+ + + L E
Sbjct: 978 EEEVNADLAARRRKLEDECTE----LKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAA 1033
Query: 128 NPQKTAFLKDRLNAIQEEHSKDLKLLHLE----------VMNLRQQLRAVK---EEEDKA 174
+ A L A+QE H + L L E + L QQ+ ++ E+E K
Sbjct: 1034 LDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKL 1093
Query: 175 QDEVQR----LTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESL 230
+ + +R L LK+ ++ +AA +++L+ +K + ++ +L ++ E+ L +
Sbjct: 1094 RMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQM 1153
Query: 231 EKSASAMLLKIQEMGSTVEVER-KQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIA 289
+K + + +E+ +E ER + + +Q A R+ L + ++ EE A
Sbjct: 1154 QKKIKELQARAEELEEELEAERAARARVEKQRAEAARE--------LEELSERLEEAGGA 1205
Query: 290 TSQLKSDLTSRDDLISKLVEENKNLQISF--------NKEHEENAYLRSEIMSLHEASEK 341
++ + R+ + +L E + + K+ E A L ++ SL +K
Sbjct: 1206 SAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQK 1265
Query: 342 AQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHA 401
+ +L + +L+ ++T+T KA + + +T+++Q
Sbjct: 1266 LEKEKSELRMEVDDLAANVETLTRAKA------------SAEKLCRTYEDQLSEAKIKVE 1313
Query: 402 SITNELQTVQNEKTQLQAHLDHL--ILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGE 459
+ +L ++ +LQ L +LE +C+ K A Q ++ LR +
Sbjct: 1314 ELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQ------SLEELRRQ 1367
Query: 460 LEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEE 519
LE + K +L + + + C+L +E + + + LQ L +
Sbjct: 1368 LEEESKAKSALAHAVQALRHD------------CDLLREQHEEEAEAQA---ELQRLLSK 1412
Query: 520 NKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFT 579
A+ E+ Q S Y A Q+ E++ E+K KLA +++++ EE V++
Sbjct: 1413 --------ANAEVAQWRSKYEADAIQRTEELEEAKKKLA-------LRLQEAEEGVEA-- 1455
Query: 580 DTSLQNDHLRKMNKYLQTKYAQANSEL---SAKRVHLQQADAHLKEVKSILERSKEELSR 636
+ + L K LQT+ EL ++ L + HL+ R +EE+ R
Sbjct: 1456 -ANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQR 1514
Query: 637 TVKCRNAALKESQKL-----------KEDLEAVE--DRENKKVGNFQRQLAEAKEDNCKV 683
++ AA +ES+ L +E LEA+E RENK N Q ++++ +
Sbjct: 1515 ELE---AAQRESRGLGTELFRLRHGHEEALEALETLKRENK---NLQEEISDLTDQVSLS 1568
Query: 684 TIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLN-QQRVQKLEAEVDQWQAR 742
++ + + ++G ++Q L + + L++ + L Q + +++AEVD R
Sbjct: 1569 GKSIQELEKTKKALEGEKSEIQAALEEAEGALE-LEETKTLRIQLELSQVKAEVD----R 1623
Query: 743 MLVMEDQ--------HNSEIESLQKALGV---AREDNRKLAMSLEQALQTNNHLQTKLDH 791
L +D+ H +ESLQ +L AR + +L +E L N L+ +L H
Sbjct: 1624 KLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDL---NDLELQLGH 1680
Query: 792 IQEQLESKE----LERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQ 847
Q + L + L+ + EE ++ AELH E+ +AL E +
Sbjct: 1681 ATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELH-EQAQAL--------ERRASLLA 1731
Query: 848 REVAELKKALDEANFRSVEVSRTNRELRQKLAELEK---ILESNKEKIKNQKTQIKLHLS 904
E+ EL+ AL++ R+ R Q+L E + +L S + NQK +++ L+
Sbjct: 1732 AELEELRAALEQG-------ERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLA 1784
Query: 905 AKANNAQNIERMKQIEKELKQMELIKD-----QYQKKNYEQSLSIQRFVCEMTNLQKEMQ 959
+ + + ++ E E K + I D + KK + S ++R + +E+Q
Sbjct: 1785 QLSGEVEEAAQERR-EAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQ 1843
Query: 960 MLAKSQYDASVR-NKQQELHLEAE-RKIRQELENRCQELEETVRHLKKCKEATENTLKEA 1017
+ A++R K+Q LEA+ R++ EL+ ++ E ++ ++K E +KE
Sbjct: 1844 ARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRK----HERRVKEL 1899
Query: 1018 SVESEQITANL 1028
+ ++E+ NL
Sbjct: 1900 AYQAEEDRKNL 1910
Score = 137 bits (344), Expect = 7e-32
Identities = 215/1022 (21%), Positives = 424/1022 (41%), Gaps = 189/1022 (18%)
Query: 95 KNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLH 154
+ C L+ +LE ++ L RL+ E+++N A L R +++E ++ L
Sbjct: 952 ERCHLLIKSKVQLEGKVKELSE---RLEDEEEVN----ADLAARRRKLEDECTE----LK 1000
Query: 155 LEVMNLRQQLRAVKEEEDKAQDEVQRLTATL-----KIASQTKKNAAIIEEELKT----- 204
++ +L+ L ++E+ +++V+ LT + +A TK+ A+ E +
Sbjct: 1001 KDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQ 1060
Query: 205 ---------TKRKMNLK--IQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERK 253
TK K+ L+ +++L L QEK LR E++ +++ +++ ++
Sbjct: 1061 AEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAK-------RKLEGDLKLTQE 1113
Query: 254 QVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKN 313
V Q+ L + ++ L+Q + E+ ++ +Q++ + +L EE +
Sbjct: 1114 SVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA 1173
Query: 314 LQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIAD 373
+ + + ++ A E+ L E E+A + + C + L + E
Sbjct: 1174 ERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALR 1233
Query: 374 HQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQ 433
H+A + ++ + E +D S+ Q ++ EK++L+ +D L +
Sbjct: 1234 HEATVAALRRKQAEGAAELGEQVD----SLQRVRQKLEKEKSELRMEVDDLAANVETLTR 1289
Query: 434 KAQDAEKRTAVQKELLESTIARL-------------RGELEASMQEKKSLLEEKERFQRE 480
AEK ++ L ++ RG L+ E LLEEKE +
Sbjct: 1290 AKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQ 1349
Query: 481 VNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQ-------------- 526
+++ + Q L ++L + + L H +Q L + L +Q
Sbjct: 1350 LSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRL 1409
Query: 527 --MASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQ 584
A+ E+ Q S Y A Q+ E++ E+K KLA +++++ EE V++ + +
Sbjct: 1410 LSKANAEVAQWRSKYEADAIQRTEELEEAKKKLA-------LRLQEAEEGVEA---ANAK 1459
Query: 585 NDHLRKMNKYLQTKYAQANSEL---SAKRVHLQQADAHLKEVKSILERSKEELSRTVKCR 641
L K LQT+ EL ++ L + HL+ R +EE+ R ++
Sbjct: 1460 CSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELE-- 1517
Query: 642 NAALKESQKL-----------KEDLEAVED--RENKKVGNFQRQLAEAKEDNCKVTIMLE 688
AA +ES+ L +E LEA+E RENK N Q ++++ + ++
Sbjct: 1518 -AAQRESRGLGTELFRLRHGHEEALEALETLKRENK---NLQEEISDLTDQVSLSGKSIQ 1573
Query: 689 NVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLN-QQRVQKLEAEVDQWQARMLVME 747
+ + ++G ++Q L + + L++ + L Q + +++AEVD R L +
Sbjct: 1574 ELEKTKKALEGEKSEIQAALEEAEGALE-LEETKTLRIQLELSQVKAEVD----RKLAEK 1628
Query: 748 DQ--------HNSEIESLQKALGV---AREDNRKLAMSLEQALQTNNHLQTKLDHIQEQL 796
D+ H +ESLQ +L AR + +L +E L N L+ +L H Q
Sbjct: 1629 DEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDL---NDLELQLGHATRQA 1685
Query: 797 ESKE----LERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAE 852
+ L + L+ + EE ++ AELH E+ +AL ++ + E+ E
Sbjct: 1686 TEAQAATRLMQAQLKEEQAGRDEEQRLAAELH-EQAQALERR--------ASLLAAELEE 1736
Query: 853 LKKALDEANFRSVEVSRTNRELRQKLAELEK---ILESNKEKIKNQKTQIKLHLSAKANN 909
L+ AL++ R+ R Q+L E + +L S + NQK
Sbjct: 1737 LRAALEQGE-------RSRRLAEQELLEATERLNLLHSQNTGLLNQK------------- 1776
Query: 910 AQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDAS 969
K++E +L Q+ ++ ++ E ++ + + + +E+ K + D S
Sbjct: 1777 -------KKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEEL----KKEQDTS 1825
Query: 970 VRNKQQELHLEAERKIRQELENRCQELEETVRHLK-KCKEATENTLKEASVESEQITANL 1028
HLE +K LE+TVR L+ + +EA + L+ + +++ A +
Sbjct: 1826 A-------HLERMKKT----------LEQTVRELQARLEEAEQAALRGGKKQVQKLEAKV 1868
Query: 1029 EE 1030
E
Sbjct: 1869 RE 1870
Score = 130 bits (328), Expect = 5e-30
Identities = 191/895 (21%), Positives = 379/895 (42%), Gaps = 120/895 (13%)
Query: 259 QQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISF 318
++ ALR ++ + LA + K++ELE + + ++DL +L E NL +
Sbjct: 895 EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQE---KNDLALQLQAEQDNLADAE 951
Query: 319 NKEH---EENAYLRSEIMSLHEASEKAQVLNDQLTKK-------CSELSCMLQTVTMEKA 368
+ H + L ++ L E E + +N L + C+EL + + + A
Sbjct: 952 ERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLA 1011
Query: 369 RIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQ----LQAHLDH- 423
+ + QA E K+ T E+ LD + A +T E + +Q Q LQA D
Sbjct: 1012 KAEKEKQA---TENKVKNLT--EEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRV 1066
Query: 424 --LILEHNQCIQKAQDAEKRTAVQKEL---LESTIARLRGELEASMQEKKSLLEEKERFQ 478
L + Q+ +D E +K+L E +L G+L+ + + ++K++ +
Sbjct: 1067 SALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLE 1126
Query: 479 REVNKTEKEIVQERCNLEKEL---AKNKVDINTLTHNLQTLEEENKHLADQMASLELQQV 535
++ K + E+ Q +E E A+ + I L + LEEE + A++ A +++
Sbjct: 1127 EKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELE--AERAARARVEKQ 1184
Query: 536 TSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYL 595
++ ++ E++ E+ A + + + +L + + +L+++ L
Sbjct: 1185 RAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAA---L 1241
Query: 596 QTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDL 655
+ K A+ +EL + LQ+ L++ KS L ++L+ V+ A ++KL
Sbjct: 1242 RRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTY 1301
Query: 656 EAVEDRENKKVGNFQRQLAEA------------------KEDNCKVTIM----------- 686
E KV QRQLA+A +E C ++ +
Sbjct: 1302 EDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSL 1361
Query: 687 --LENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLN-----QQRVQKLEAEVDQW 739
L L SK + AL ++ R D ++ + E + Q+ + K AEV QW
Sbjct: 1362 EELRRQLEEESKAKSALAHA-VQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQW 1420
Query: 740 QARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESK 799
+++ Q E+E E +KLA+ L++A + K +++
Sbjct: 1421 RSKYEADAIQRTEELE----------EAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRL 1470
Query: 800 ELERQNLETFKDRMTEESKV--EAELHAERIEALRKQFQTERETTKKVAQR-------EV 850
+ E +++ +R T + + + H ER R++ + E + + AQR E+
Sbjct: 1471 QTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTEL 1530
Query: 851 AELKKALDEANFRSVEVSRTNRELRQKLAELE----------KILESNKEKIKNQKTQIK 900
L+ +EA + R N+ L++++++L + LE K+ ++ +K++I+
Sbjct: 1531 FRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ 1590
Query: 901 LHLSAKANNAQNIERMK--QIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEM 958
L +A A +E K +I+ EL Q++ D+ + E+ +++R N Q+ +
Sbjct: 1591 AALE-EAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRR------NHQRAV 1643
Query: 959 QMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEAT---ENTLK 1015
+ L ++ DA R + + L L ++K+ +L + +L R + + AT + LK
Sbjct: 1644 ESL-QASLDAETRARNEALRL--KKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLK 1700
Query: 1016 EASV---ESEQITANLEEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDV 1067
E E +++ A L E + + R L EL + R GE + +Q++
Sbjct: 1701 EEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQEL 1755
Score = 116 bits (291), Expect = 1e-25
Identities = 163/819 (19%), Positives = 348/819 (42%), Gaps = 125/819 (15%)
Query: 141 AIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEE 200
A++ + ++ L +V +L++ + +++E+ + + EV L A ++ ++ K +A +
Sbjct: 1240 ALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCR 1299
Query: 201 ELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQ 260
+ + +K++EL+RQLA R L+ + E+ +E + + L +
Sbjct: 1300 TYEDQLSEAKIKVEELQRQLADASTQRGRLQTESG-------ELSRLLEEKECLISQLSR 1352
Query: 261 NCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNK 320
S++ + L +E K K L A L+ D DL+ +
Sbjct: 1353 GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDC----DLL--------------RE 1394
Query: 321 EHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQV 380
+HEE A ++E+ L KA Q K E + +T +E+A+
Sbjct: 1395 QHEEEAEAQAELQRL---LSKANAEVAQWRSK-YEADAIQRTEELEEAK----------- 1439
Query: 381 EQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEK 440
K + QE ++AA+A + +++ K +LQ + + LE + A +K
Sbjct: 1440 --KKLALRLQEAEEGVEAANA----KCSSLEKAKLRLQTESEDVTLELERATSAAAALDK 1493
Query: 441 RTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELA 500
+ + LE +++E++ ++E QRE+ ++ E L EL
Sbjct: 1494 K---------------QRHLERALEERR---RQEEEMQRELEAAQR----ESRGLGTELF 1531
Query: 501 KNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYE 560
+ + L+TL+ ENK+L ++++ L +D L+ + ++++ ++K L E
Sbjct: 1532 RLRHGHEEALEALETLKRENKNLQEEISDL------TDQVSLSGKSIQELEKTKKALEGE 1585
Query: 561 NGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHL 620
++Q +++ E ++ +L+ +Q + +Q +E+ K + A+L
Sbjct: 1586 KSEIQAALEEAEGALELEETKTLR----------IQLELSQVKAEVDRKLAEKDEECANL 1635
Query: 621 -KEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKED 679
+ + +E + L + RN AL+ +K++ DL +E ++G+ RQ EA+
Sbjct: 1636 RRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE----LQLGHATRQATEAQ-- 1689
Query: 680 NCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQW 739
A+ MQ L++ Q A L ++ ++R L AE+++
Sbjct: 1690 ------------AATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEEL 1737
Query: 740 QARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESK 799
+A + +Q ++ L A E L L L+ L + ++E
Sbjct: 1738 RAAL----EQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEA 1793
Query: 800 ELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTER--ETTKKVAQREVAELKKAL 857
ER+ E E++K A E L+K+ T E KK ++ V EL+ L
Sbjct: 1794 AQERREAE-------EKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARL 1846
Query: 858 DEANFRSVEVSRTN-RELRQKLAELEKILESNKEK-------IKNQKTQIKLHLSAKANN 909
+EA ++ + ++L K+ ELE L++ ++K ++ + ++K +
Sbjct: 1847 EEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEED 1906
Query: 910 AQNIERMKQ-IEKELKQMELIKDQYQKKNYEQSLSIQRF 947
+N+ RM+ ++K +++ K Q+++ + + ++ ++
Sbjct: 1907 RKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKY 1945
Score = 102 bits (255), Expect = 2e-21
Identities = 158/693 (22%), Positives = 296/693 (42%), Gaps = 87/693 (12%)
Query: 107 LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQ--- 163
L L++ + I +L K L Q L+ +L EE SK L V LR
Sbjct: 1336 LSRLLEEKECLISQLSRGKALAAQSLEELRRQL----EEESKAKSALAHAVQALRHDCDL 1391
Query: 164 LRAVKEEEDKAQDEVQRLT--ATLKIAS-QTKKNAAIIE--EELKTTKRKMNLKIQELRR 218
LR EEE +AQ E+QRL A ++A ++K A I+ EEL+ K+K+ L++QE
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEE 1451
Query: 219 QLAQEKYLRESLEKSASAMLLKIQEMGSTVEVER----------KQVHILQQNCIALRDS 268
+ SLEK+ + L+ + T+E+ER KQ H L++ R
Sbjct: 1452 GVEAANAKCSSLEKAK--LRLQTESEDVTLELERATSAAAALDKKQRH-LERALEERRRQ 1508
Query: 269 IQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYL 328
+ Q L Q++ L +L+ + + L ENKNLQ + ++ +
Sbjct: 1509 EEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLS 1568
Query: 329 RSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIAD-HQAILQVEQKMMTQ 387
I L + + + ++ E L+ + RI + Q +V++K+ +
Sbjct: 1569 GKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEK 1628
Query: 388 TFQEQNL------LLDAAHASITNELQTVQNE----KTQLQAHLDHLILEHNQCIQKAQD 437
+ NL +++ AS+ E + +NE K +++ L+ L L+ ++A +
Sbjct: 1629 DEECANLRRNHQRAVESLQASLDAETRA-RNEALRLKKKMEGDLNDLELQLGHATRQATE 1687
Query: 438 AEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEK 497
A+ T + ++A ++E+++ +E++R E+++ + + + L
Sbjct: 1688 AQAATRL---------------MQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAA 1732
Query: 498 ELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKL 557
EL + + + E ++ LA+Q EL + T + L Q + + K
Sbjct: 1733 ELEELRAALEQ--------GERSRRLAEQ----ELLEATERLNLLHSQNTGLLNQKK--- 1777
Query: 558 AYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQAD 617
KL+ + QL +V+ + + + + K T A EL + Q
Sbjct: 1778 -----KLEADLAQLSGEVE---EAAQERREAEEKAKKAITDAAMMAEELKKE----QDTS 1825
Query: 618 AHLKEVKSILERSKEEL-SRTVKCRNAAL----KESQKLK---EDLEAVEDRENKKVGNF 669
AHL+ +K LE++ EL +R + AAL K+ QKL+ +LEA D E KK
Sbjct: 1826 AHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEA 1885
Query: 670 QRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRV 729
+ + + + ++ E + ++MQ ++K+Q ++ + +++ + N +
Sbjct: 1886 LKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKY 1945
Query: 730 QKLEAEVDQWQARMLVMEDQHNSEIESLQKALG 762
+K + E+D + R + E Q N + ALG
Sbjct: 1946 RKAQHELDDAEERADMAETQANKLRARTRDALG 1978
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.124 0.323
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,176,284
Number of Sequences: 37866
Number of extensions: 1491299
Number of successful extensions: 27454
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 472
Number of HSP's successfully gapped in prelim test: 1365
Number of HSP's that attempted gapping in prelim test: 8600
Number of HSP's gapped (non-prelim): 8248
length of query: 1101
length of database: 18,247,518
effective HSP length: 113
effective length of query: 988
effective length of database: 13,968,660
effective search space: 13801036080
effective search space used: 13801036080
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.