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Search of human proteins with 32880208
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
(849 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 1697 0.0
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 1685 0.0
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 1009 0.0
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 1007 0.0
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 815 0.0
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 815 0.0
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 391 e-108
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 358 9e-99
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 273 6e-73
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 273 6e-73
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 263 7e-70
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 263 7e-70
gi|52485606 formin-like 2 [Homo sapiens] 248 1e-65
gi|33356148 formin-like 1 [Homo sapiens] 221 3e-57
gi|157168329 formin 1 [Homo sapiens] 200 4e-51
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 184 2e-46
gi|160707881 formin 2 [Homo sapiens] 180 4e-45
gi|145309324 FH2 domain containing 1 [Homo sapiens] 179 1e-44
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 155 2e-37
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 139 1e-32
gi|56549694 enabled homolog isoform a [Homo sapiens] 70 1e-11
gi|39930375 enabled homolog isoform b [Homo sapiens] 70 1e-11
gi|210032580 SET domain containing 1B [Homo sapiens] 67 7e-11
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens] 63 1e-09
gi|183396804 Regulation of nuclear pre-mRNA domain containing 2 ... 63 1e-09
gi|11386183 WAS protein family, member 2 [Homo sapiens] 60 7e-09
gi|149944526 additional sex combs like 3 [Homo sapiens] 59 2e-08
gi|10937869 survival of motor neuron 2, centromeric isoform d [H... 58 3e-08
gi|13259527 survival of motor neuron 2, centromeric isoform a [H... 58 3e-08
gi|4507091 survival of motor neuron 1, telomeric isoform d [Homo... 58 3e-08
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 1697 bits (4394), Expect = 0.0
Identities = 849/849 (100%), Positives = 849/849 (100%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF 60
MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF
Sbjct: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF 60
Query: 61 FCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND 120
FCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND
Sbjct: 61 FCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND 120
Query: 121 GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH 180
GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH
Sbjct: 121 GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH 180
Query: 181 LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE 240
LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE
Sbjct: 181 LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE 240
Query: 241 EFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP 300
EFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP
Sbjct: 241 EFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP 300
Query: 301 PSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQN 360
PSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQN
Sbjct: 301 PSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQN 360
Query: 361 SPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLE 420
SPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLE
Sbjct: 361 SPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLE 420
Query: 421 NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 480
NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE
Sbjct: 421 NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 480
Query: 481 VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI 540
VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI
Sbjct: 481 VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI 540
Query: 541 LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN 600
LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN
Sbjct: 541 LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN 600
Query: 601 LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR 660
LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR
Sbjct: 601 LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR 660
Query: 661 QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG 720
QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG
Sbjct: 661 QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG 720
Query: 721 YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ 780
YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ
Sbjct: 721 YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ 780
Query: 781 QKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKV 840
QKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKV
Sbjct: 781 QKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKV 840
Query: 841 CNHGNKPYL 849
CNHGNKPYL
Sbjct: 841 CNHGNKPYL 849
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 1685 bits (4364), Expect = 0.0
Identities = 844/846 (99%), Positives = 845/846 (99%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF 60
MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF
Sbjct: 264 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF 323
Query: 61 FCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND 120
FCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND
Sbjct: 324 FCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND 383
Query: 121 GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH 180
GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH
Sbjct: 384 GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH 443
Query: 181 LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE 240
LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE
Sbjct: 444 LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE 503
Query: 241 EFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP 300
EFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP
Sbjct: 504 EFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP 563
Query: 301 PSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQN 360
PSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQN
Sbjct: 564 PSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQN 623
Query: 361 SPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLE 420
SPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLE
Sbjct: 624 SPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLE 683
Query: 421 NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 480
NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE
Sbjct: 684 NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 743
Query: 481 VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI 540
VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI
Sbjct: 744 VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI 803
Query: 541 LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN 600
LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN
Sbjct: 804 LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN 863
Query: 601 LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR 660
LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR
Sbjct: 864 LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR 923
Query: 661 QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG 720
QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG
Sbjct: 924 QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG 983
Query: 721 YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ 780
YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ
Sbjct: 984 YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ 1043
Query: 781 QKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKV 840
QKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKV
Sbjct: 1044 QKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKV 1103
Query: 841 CNHGNK 846
CNH N+
Sbjct: 1104 CNHENQ 1109
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 1009 bits (2609), Expect = 0.0
Identities = 503/841 (59%), Positives = 658/841 (78%), Gaps = 21/841 (2%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF 60
+ +ERSL LLA+A+DP+ PNMMT++VK+LSA+CIVGEE+IL+++L A+T+A E +RF
Sbjct: 251 LGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITTAAERNNRERF 310
Query: 61 FCIVEGLRHN-SVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKN 119
IVEGL + ++QLQVACMQ INALVTSP +LDFR+H+RNEF+R GLK +LP+LK +N
Sbjct: 311 SPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKEN 370
Query: 120 DGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQ 179
D LDIQLKVFDE+KE+DL ELSHRL DIRAE+D+ +VY+++++ +K+T AE YF+SILQ
Sbjct: 371 DELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQ 430
Query: 180 HLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKL 239
H LLIRNDY+IR QY+K+I+ECVSQIVLH GMDPDF YR+RLD+DLT +D C+++AK+
Sbjct: 431 HFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKV 490
Query: 240 EEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPL 299
EE E+KA+E KKF++EFT QE QAELQK++ KI EL+AE+Q ++Q L + IP
Sbjct: 491 EESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPG 550
Query: 300 PPSKEG--GTGHSALPPPPPLPSGGGVPPPPPP-------PPPPPLPGMRMPFSGPVPPP 350
PP+ G G PP PPLP G +PPPPPP PPPPP P + F GP PPP
Sbjct: 551 PPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPP---LLFGGPPPPP 607
Query: 351 PPLGFLGGQNSPP--LPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNEN 408
P LGG PP LP+G+K KK +KPE+SM+R+NW KI P E++ENCFW++V E+
Sbjct: 608 P----LGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKED 663
Query: 409 KYENVDLLCKLENTFCCQQKERREEEDIEEKKS--IKKKIKELKFLDSKIAQNLSIFLSS 466
K+EN DL KL F Q K ++ E +EEKK+ KKK+KEL+ LD K AQNLSIFL S
Sbjct: 664 KFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGS 723
Query: 467 FRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVV 526
+R+PYE+IR +ILEV+E L+E++IQNL+KHLP+Q+ LN L++ K+EY +LCEPEQF VV
Sbjct: 724 YRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVV 783
Query: 527 MSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNY 586
MS+VK L+PRLS+ILFKL FEE +NNIKP I+AV+ ACEE+KKS+SF++LLELVLL+GNY
Sbjct: 784 MSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNY 843
Query: 587 MNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDK 646
MN+GSRNAQ+ GF ++ LCK++DTKSADQKTTLLHF+ +ICEEKY DIL F ++LE ++
Sbjct: 844 MNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVES 903
Query: 647 ASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSK 706
ASKVS + L+ NL M +Q+ LE++++ FP E+ HDKFV KM+ F +A+EQYE LS
Sbjct: 904 ASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLST 963
Query: 707 LHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVR 766
+H NM KLY+++ Y+ D K VS+E+F DLNNFRT F++A++EN K+RE EEK +R +
Sbjct: 964 MHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAK 1023
Query: 767 IAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVR 826
+AKE AE+E+LERQ+KKK+L+++ EGDETGVMDNLLEALQSGAAFRDRRKR P D R
Sbjct: 1024 LAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNPDNR 1083
Query: 827 Q 827
+
Sbjct: 1084 R 1084
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 1007 bits (2604), Expect = 0.0
Identities = 501/834 (60%), Positives = 655/834 (78%), Gaps = 21/834 (2%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF 60
+ +ERSL LLA+A+DP+ PNMMT++VK+LSA+CIVGEE+IL+++L A+T+A E +RF
Sbjct: 251 LGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITTAAERNNRERF 310
Query: 61 FCIVEGLRHN-SVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKN 119
IVEGL + ++QLQVACMQ INALVTSP +LDFR+H+RNEF+R GLK +LP+LK +N
Sbjct: 311 SPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKEN 370
Query: 120 DGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQ 179
D LDIQLKVFDE+KE+DL ELSHRL DIRAE+D+ +VY+++++ +K+T AE YF+SILQ
Sbjct: 371 DELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQ 430
Query: 180 HLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKL 239
H LLIRNDY+IR QY+K+I+ECVSQIVLH GMDPDF YR+RLD+DLT +D C+++AK+
Sbjct: 431 HFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKV 490
Query: 240 EEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPL 299
EE E+KA+E KKF++EFT QE QAELQK++ KI EL+AE+Q ++Q L + IP
Sbjct: 491 EESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPG 550
Query: 300 PPSKEG--GTGHSALPPPPPLPSGGGVPPPPPP-------PPPPPLPGMRMPFSGPVPPP 350
PP+ G G PP PPLP G +PPPPPP PPPPP P + F GP PPP
Sbjct: 551 PPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPP---LLFGGPPPPP 607
Query: 351 PPLGFLGGQNSPP--LPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNEN 408
P LGG PP LP+G+K KK +KPE+SM+R+NW KI P E++ENCFW++V E+
Sbjct: 608 P----LGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKED 663
Query: 409 KYENVDLLCKLENTFCCQQKERREEEDIEEKKS--IKKKIKELKFLDSKIAQNLSIFLSS 466
K+EN DL KL F Q K ++ E +EEKK+ KKK+KEL+ LD K AQNLSIFL S
Sbjct: 664 KFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGS 723
Query: 467 FRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVV 526
+R+PYE+IR +ILEV+E L+E++IQNL+KHLP+Q+ LN L++ K+EY +LCEPEQF VV
Sbjct: 724 YRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVV 783
Query: 527 MSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNY 586
MS+VK L+PRLS+ILFKL FEE +NNIKP I+AV+ ACEE+KKS+SF++LLELVLL+GNY
Sbjct: 784 MSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNY 843
Query: 587 MNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDK 646
MN+GSRNAQ+ GF ++ LCK++DTKSADQKTTLLHF+ +ICEEKY DIL F ++LE ++
Sbjct: 844 MNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVES 903
Query: 647 ASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSK 706
ASKVS + L+ NL M +Q+ LE++++ FP E+ HDKFV KM+ F +A+EQYE LS
Sbjct: 904 ASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLST 963
Query: 707 LHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVR 766
+H NM KLY+++ Y+ D K VS+E+F DLNNFRT F++A++EN K+RE EEK +R +
Sbjct: 964 MHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAK 1023
Query: 767 IAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTP 820
+AKE AE+E+LERQ+KKK+L+++ EGDETGVMDNLLEALQSGAAFRDRRKR P
Sbjct: 1024 LAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIP 1077
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 815 bits (2105), Expect = 0.0
Identities = 455/989 (46%), Positives = 612/989 (61%), Gaps = 174/989 (17%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE-ESILEEVLEALTSAGEEKKIDR 59
+ E + LL +A+DP PNMM D KLLSA+CI+ + E + E VLEA+T E +++R
Sbjct: 226 LETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVER 285
Query: 60 FFCIVEGLRHNS-VQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIK 118
F +++GL+ + + L+V C+QLINAL+T ++LDFR+HIR+E MR GL ++L +L+ I+
Sbjct: 286 FQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIE 345
Query: 119 NDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISIL 178
N+ + +QL VFDE EED ++L RL+DIR E+D+ +V+ ++ +TVK+++AE +F+SIL
Sbjct: 346 NEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSIL 405
Query: 179 QHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAK 238
QHLLL+RNDY R QY+KLI+EC+SQIVLH++G DPDF R L +++ +D ID+ K
Sbjct: 406 QHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCR-HLQIEIEGLIDQMIDKTK 464
Query: 239 LEEFEEKASEL-----------------YKKFEKEF----------------------TD 259
+E+ E KA+EL KK E +F T+
Sbjct: 465 VEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATE 524
Query: 260 HQETQAELQKKEAKINELQAELQAFKSQFGAL---------------------------- 291
Q+ +AE+ + ++ +L EL+ K + +L
Sbjct: 525 KQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSG 584
Query: 292 --------PADCNIPLPPSKE--------GGT---------GHSALPPPPP--------- 317
P D P PP GG G +A+ PPPP
Sbjct: 585 TIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPP 644
Query: 318 ---------------LPSGGGVPPPPP-------PPPPPPLPGMR--------------- 340
LP G +PPPPP PPPPPPLPG
Sbjct: 645 PPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGM 704
Query: 341 ------MPFSGPVPPPPPLGFLGGQNSPP-------------------LPILPFGLKPKK 375
+P +PPPPP F GG PP P+LPFGL PKK
Sbjct: 705 PPPPPPLPGGPGIPPPPP--FPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKK 762
Query: 376 EFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQ---QKERRE 432
+KPE+ +RR NW K+ +++++CFW KV E+++EN +L KL TF Q K +++
Sbjct: 763 LYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKD 822
Query: 433 EEDIEEKKSI-KKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMI 491
+E EEKKS+ KKK+KELK LDSK AQNLSIFL SFR+PY+EI+ +ILEV+E L ESMI
Sbjct: 823 QEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMI 882
Query: 492 QNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVN 551
QNLIK +P+ EQL LS+ K EY +L E EQF VVM V RLRPRL+AILFKLQF EQV
Sbjct: 883 QNLIKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVE 942
Query: 552 NIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTK 611
NIKP+I++V+ ACEE++KS+SFS LLE+ LL+GNYMNAGSRNA FGFN+S LCKL+DTK
Sbjct: 943 NIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTK 1002
Query: 612 SADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEK 671
S DQK TLLHFL E+CE YPD+L F D+L ++KAS+VS E L+KNL QM +Q+ +E+
Sbjct: 1003 STDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVER 1062
Query: 672 ELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSV 731
+++ FP D DKFV KM+ FV A+EQY L +H NME LY+ + Y+ D KK+SV
Sbjct: 1063 DVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSV 1122
Query: 732 EDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKT 791
E+F DL+NFR F+QA+KEN K+RE EEK +R ++AKE AE+ERLE+QQK+++L++M
Sbjct: 1123 EEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNA 1182
Query: 792 EGDETGVMDNLLEALQSGAAFRDRRKRTP 820
EGDETGVMD+LLEALQSGAAF RRKR P
Sbjct: 1183 EGDETGVMDSLLEALQSGAAF--RRKRGP 1209
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 815 bits (2105), Expect = 0.0
Identities = 455/989 (46%), Positives = 612/989 (61%), Gaps = 174/989 (17%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE-ESILEEVLEALTSAGEEKKIDR 59
+ E + LL +A+DP PNMM D KLLSA+CI+ + E + E VLEA+T E +++R
Sbjct: 235 LETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVER 294
Query: 60 FFCIVEGLRHNS-VQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIK 118
F +++GL+ + + L+V C+QLINAL+T ++LDFR+HIR+E MR GL ++L +L+ I+
Sbjct: 295 FQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIE 354
Query: 119 NDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISIL 178
N+ + +QL VFDE EED ++L RL+DIR E+D+ +V+ ++ +TVK+++AE +F+SIL
Sbjct: 355 NEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSIL 414
Query: 179 QHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAK 238
QHLLL+RNDY R QY+KLI+EC+SQIVLH++G DPDF R L +++ +D ID+ K
Sbjct: 415 QHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCR-HLQIEIEGLIDQMIDKTK 473
Query: 239 LEEFEEKASEL-----------------YKKFEKEF----------------------TD 259
+E+ E KA+EL KK E +F T+
Sbjct: 474 VEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATE 533
Query: 260 HQETQAELQKKEAKINELQAELQAFKSQFGAL---------------------------- 291
Q+ +AE+ + ++ +L EL+ K + +L
Sbjct: 534 KQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSG 593
Query: 292 --------PADCNIPLPPSKE--------GGT---------GHSALPPPPP--------- 317
P D P PP GG G +A+ PPPP
Sbjct: 594 TIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPP 653
Query: 318 ---------------LPSGGGVPPPPP-------PPPPPPLPGMR--------------- 340
LP G +PPPPP PPPPPPLPG
Sbjct: 654 PPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGM 713
Query: 341 ------MPFSGPVPPPPPLGFLGGQNSPP-------------------LPILPFGLKPKK 375
+P +PPPPP F GG PP P+LPFGL PKK
Sbjct: 714 PPPPPPLPGGPGIPPPPP--FPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKK 771
Query: 376 EFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQ---QKERRE 432
+KPE+ +RR NW K+ +++++CFW KV E+++EN +L KL TF Q K +++
Sbjct: 772 LYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKD 831
Query: 433 EEDIEEKKSI-KKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMI 491
+E EEKKS+ KKK+KELK LDSK AQNLSIFL SFR+PY+EI+ +ILEV+E L ESMI
Sbjct: 832 QEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMI 891
Query: 492 QNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVN 551
QNLIK +P+ EQL LS+ K EY +L E EQF VVM V RLRPRL+AILFKLQF EQV
Sbjct: 892 QNLIKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVE 951
Query: 552 NIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTK 611
NIKP+I++V+ ACEE++KS+SFS LLE+ LL+GNYMNAGSRNA FGFN+S LCKL+DTK
Sbjct: 952 NIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTK 1011
Query: 612 SADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEK 671
S DQK TLLHFL E+CE YPD+L F D+L ++KAS+VS E L+KNL QM +Q+ +E+
Sbjct: 1012 STDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVER 1071
Query: 672 ELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSV 731
+++ FP D DKFV KM+ FV A+EQY L +H NME LY+ + Y+ D KK+SV
Sbjct: 1072 DVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSV 1131
Query: 732 EDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKT 791
E+F DL+NFR F+QA+KEN K+RE EEK +R ++AKE AE+ERLE+QQK+++L++M
Sbjct: 1132 EEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNA 1191
Query: 792 EGDETGVMDNLLEALQSGAAFRDRRKRTP 820
EGDETGVMD+LLEALQSGAAF RRKR P
Sbjct: 1192 EGDETGVMDSLLEALQSGAAF--RRKRGP 1218
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 391 bits (1005), Expect = e-108
Identities = 266/908 (29%), Positives = 466/908 (51%), Gaps = 98/908 (10%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKID 58
++ S++++A+++ + V+++L AVC+V G + +L+ +L A E +
Sbjct: 199 LAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQ 258
Query: 59 RFFCIVE---GLRHNSVQLQVACMQLINALVTSP---DDLDFRLHIRNEFMRCGLKEILP 112
++ G + V L+ A M INA+++ + LDFRLH+R EF+ G++ ++
Sbjct: 259 TLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVID 318
Query: 113 NLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEG 172
L+ +N LD L F+ + ED E + R E + + A ++ + + + A
Sbjct: 319 KLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYP 378
Query: 173 YFISILQHLLLI---RNDYFIRQQYFKLIDECVSQIVLHRD-GMDPDFTYRKRLDLDLTQ 228
+F+SIL H L + R+ + QY+ L+D + QIV+ D G DPD T + + ++
Sbjct: 379 HFMSILHHCLQMPYKRSGNTV--QYWLLLDRIIQQIVIQNDKGQDPDSTPLE--NFNIKN 434
Query: 229 FVDICIDQAKLEEFEEKASELYK-----------------------------------KF 253
V + +++ ++++++E+A ++ K K
Sbjct: 435 VVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKL 494
Query: 254 EKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALP 313
EKE T+H++ + ++ A+++EL G P P P S G S LP
Sbjct: 495 EKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPG----SLLP 550
Query: 314 PPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPP--PPPLGFLGGQNSPPLPILPFGL 371
PPPP P GG+ PPPPPP PP GP PP PPPLG + P P P GL
Sbjct: 551 PPPPPPLPGGMLPPPPPPLPP---------GGPPPPPGPPPLGAI-----MPPPGAPMGL 596
Query: 372 KPKKEF--KPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKE 429
KK+ +P +++ NW K+ P E W ++++ K + L LE TF Q++
Sbjct: 597 ALKKKSIPQPTNALKSFNWSKL-PENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQ 655
Query: 430 ----------RREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMIL 479
++E + I++ S K K+KEL +D + AQN +I LS ++ +EI+ IL
Sbjct: 656 QDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAIL 715
Query: 480 EVDETR-LAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLS 538
+DE L + M++ L+K +P++ ++ L + K E + + ++F+ MS + + RL
Sbjct: 716 TMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQ 775
Query: 539 AILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFG 598
++ FK +F E+V +KP + A+ + EE+ +S + +LLE+VL GNYMN G R +G
Sbjct: 776 SLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYG 834
Query: 599 FNLSSLCKLKDTKSA-DQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEK 657
F +SSL K+ DTKS+ D+ TLLH+L+ I E KYP +LN ++L + +A+KV++ L+K
Sbjct: 835 FKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDK 894
Query: 658 NLRQMGRQLQQLEKELE--TFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLY 715
+ + L+ +E ELE PP+ DKFV+ +S+F+ A + + L + L+
Sbjct: 895 EISTLRSGLKAVETELEYQKSQPPQP-GDKFVSVVSQFITVASFSFSDVEDLLAEAKDLF 953
Query: 716 QSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIK-KREAEEKEKRVRIAKELAER 774
+ ++ + K+ ++F + F +A +EN +++ EE+E+R R+ +L E+
Sbjct: 954 TKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQ 1013
Query: 775 ERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAF-RDRRKRTPMPKDVRQSLSPMS 833
ER+ +K K +E+G D+L+ AL+SG F +D K K + ++ S
Sbjct: 1014 RERERKMRK-----AKENSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSS 1068
Query: 834 -QRPVLKV 840
+RP+ K+
Sbjct: 1069 RERPITKL 1076
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 358 bits (920), Expect = 9e-99
Identities = 251/862 (29%), Positives = 447/862 (51%), Gaps = 71/862 (8%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKID 58
+++ ++S +A+++ + V+++L AVC+V G + +L+ +L A E +
Sbjct: 195 LAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQ 254
Query: 59 RFFCIVE---GLRHNSVQLQVACMQLINALVTS---PDDLDFRLHIRNEFMRCGLKEILP 112
++ G + V L+ A M INA++ + D+L+FRLH+R EF+ G++ ++
Sbjct: 255 TLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVID 314
Query: 113 NLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEG 172
L+ +N LD L F+ + ED EL+ R + + + A ++ ++ +K T A
Sbjct: 315 KLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYP 374
Query: 173 YFISILQHLLLI---RNDYFIRQQYFKLIDECVSQIVLHRD-GMDPDFTYRKRLDLDLTQ 228
+S+L H L + RN + +Q ++L+D + QIVL + G+DPD + + ++
Sbjct: 375 CLLSVLHHCLQMPYKRNGGYFQQ--WQLLDRILQQIVLQDERGVDPDLAPLE--NFNVKN 430
Query: 229 FVDICIDQAKLEEFEEKASELYKKF--------------EKEFTDHQETQAELQKKEAKI 274
V++ I++ +++++ ++A + K+ E + + +E L K + K+
Sbjct: 431 IVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKL 490
Query: 275 NELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLP-------SGGGVPPP 327
EL+ + Q L A + E TG + PPPP P + +PPP
Sbjct: 491 ARESQELRQARGQVAELVAQLS-------ELSTGPVSSPPPPGGPLTLSSSMTTNDLPPP 543
Query: 328 PPP--------PPPPPLPGMRMPFSGPVPP--PPPLGFLGGQNSPPLPILPFGLKPKKEF 377
PPP PPPPPLP P P PP PP LG P P L+ K+
Sbjct: 544 PPPLPFACCPPPPPPPLP----PGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVP 599
Query: 378 KPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIE 437
+P ++ NW+K+ E W ++++ + + L E F Q+ ++E E
Sbjct: 600 QPSHPLKSFNWVKLN-EERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTE 658
Query: 438 EKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETR-LAESMIQNLIK 496
+ +K+KEL +D + AQN I LS ++ EEIR IL++DE LA+ M++ L+K
Sbjct: 659 DIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLK 718
Query: 497 HLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPD 556
+P++ ++ L + K E + ++F+ MS + + RL A+ FK +F+E++ KP
Sbjct: 719 FIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPK 778
Query: 557 IMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSA-DQ 615
+ A+ A E+ +SK ++LE++L +GN+MN G R +GF ++SL K+ DTKS+ D+
Sbjct: 779 VEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGG-AYGFRVASLNKIADTKSSIDR 837
Query: 616 KTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEK---NLRQMGRQLQQLEKE 672
+LLH+L+ I E+ +PDILN +L+ L +A+KV++ LEK NLR+ R ++ LE +
Sbjct: 838 NISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQ 897
Query: 673 LETFPPPEDLHDKFVTKMSRFV-ISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSV 731
P DKFV MS F+ +S+ E +L+E +K ++++ + D K+
Sbjct: 898 RRQVREPS---DKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHD-SKMQP 953
Query: 732 EDFLTDLNNFRTTFMQAIKE-NIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMK 790
++F + F F +A ++ +R EE+E+R R+ L E+ ER Q+++++L
Sbjct: 954 DEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAG 1013
Query: 791 TEGDETGVMDNLLEALQSGAAF 812
+ +E G D+L+ AL+SG F
Sbjct: 1014 SSLEEGGEFDDLVSALRSGEVF 1035
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 273 bits (697), Expect = 6e-73
Identities = 227/889 (25%), Positives = 410/889 (46%), Gaps = 96/889 (10%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEES--ILEEVLEALTSAGEEKKID 58
+S + + L++A+D + + V +LL+A+CI E + + L+ + ++
Sbjct: 119 LSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQY-- 176
Query: 59 RFFCIVEGLR-HNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCI 117
RF ++ L ++V V + +INA++ P+DL R +RNEF+ L ++L L+ +
Sbjct: 177 RFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDL 236
Query: 118 KNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISI 177
++ L IQL+ F+E K ED EL + ++ +V+ ++ V + +S+
Sbjct: 237 EDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPVSAQLLSV 294
Query: 178 LQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLT---------- 227
LQ LL + Q ++ ++ V++ VL + T + ++ L+
Sbjct: 295 LQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ-ECTLEEVVERLLSVKGRPRPSPL 353
Query: 228 ----QFVDICIDQAKLEEFEEKASELYKKFEK---------EFTDHQETQAELQKKEAKI 274
+ V +DQ++ + + E E DH ++++ L+ + +
Sbjct: 354 VKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRA 413
Query: 275 NELQAELQAFKSQFGALP---ADCNIPLPPSKEGGTGHSALP---PPPPLPSGGGVPPPP 328
E QA LP A+ P PP G ALP PPPPLP G + PP
Sbjct: 414 LEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPA 473
Query: 329 PP-------------PPPPPLPGMRMPFSGPVPPPPPL--GFLGGQNSPPLPILPFGLKP 373
PP PPPPPLPG+ P PPPPPL G G PP P+LP P
Sbjct: 474 PPLPPPLPGSCEFLPPPPPPLPGLGCP-----PPPPPLLPGMGWGPPPPPPPLLPCTCSP 528
Query: 374 --------------------------KKEFKPEISMRRLNWLKIRPHEMTE-NCFWIKVN 406
++ P + M++LNW K+ + E N W ++
Sbjct: 529 PVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLS 588
Query: 407 ENKYENVDL-LCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLS 465
E V+ +E F + +E + + +K+ KE+ FLD+K + NL+IFL
Sbjct: 589 SPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRA--RKEPKEITFLDAKKSLNLNIFLK 646
Query: 466 SFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVV 525
F+ EE+ MI D T+ +++ L+K LP++ ++ +L F E + L + F +
Sbjct: 647 QFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYL 706
Query: 526 VMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGN 585
++ + + R+ +L ++ ++P V ACE + S+ +L+L +GN
Sbjct: 707 LLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGN 766
Query: 586 YMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLD 645
++N GS GF +S+L KL +TKS + TLLH ++E E+ +PD+L DLE
Sbjct: 767 FLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPS 826
Query: 646 KASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLS 705
+A+ +++E + ++L LE E + ++ +++ ++ + + L
Sbjct: 827 QAAGINLEIIRSEASSNLKKL--LETERKVSASVAEVQEQYTERLQASI----SAFRALD 880
Query: 706 KLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRV 765
+L E +E+ + + Y D +++S+ED + + FR F++A+KEN ++E K +R
Sbjct: 881 ELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERR 940
Query: 766 RIAKELAERE-RLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFR 813
+ ++LAE E R R + K + + + +E V+D LL ++ G R
Sbjct: 941 K--QQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLR 987
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 273 bits (697), Expect = 6e-73
Identities = 227/889 (25%), Positives = 410/889 (46%), Gaps = 96/889 (10%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEES--ILEEVLEALTSAGEEKKID 58
+S + + L++A+D + + V +LL+A+CI E + + L+ + ++
Sbjct: 119 LSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQY-- 176
Query: 59 RFFCIVEGLR-HNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCI 117
RF ++ L ++V V + +INA++ P+DL R +RNEF+ L ++L L+ +
Sbjct: 177 RFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDL 236
Query: 118 KNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISI 177
++ L IQL+ F+E K ED EL + ++ +V+ ++ V + +S+
Sbjct: 237 EDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPVSAQLLSV 294
Query: 178 LQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLT---------- 227
LQ LL + Q ++ ++ V++ VL + T + ++ L+
Sbjct: 295 LQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ-ECTLEEVVERLLSVKGRPRPSPL 353
Query: 228 ----QFVDICIDQAKLEEFEEKASELYKKFEK---------EFTDHQETQAELQKKEAKI 274
+ V +DQ++ + + E E DH ++++ L+ + +
Sbjct: 354 VKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRA 413
Query: 275 NELQAELQAFKSQFGALP---ADCNIPLPPSKEGGTGHSALP---PPPPLPSGGGVPPPP 328
E QA LP A+ P PP G ALP PPPPLP G + PP
Sbjct: 414 LEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPA 473
Query: 329 PP-------------PPPPPLPGMRMPFSGPVPPPPPL--GFLGGQNSPPLPILPFGLKP 373
PP PPPPPLPG+ P PPPPPL G G PP P+LP P
Sbjct: 474 PPLPPPLPGSCEFLPPPPPPLPGLGCP-----PPPPPLLPGMGWGPPPPPPPLLPCTCSP 528
Query: 374 --------------------------KKEFKPEISMRRLNWLKIRPHEMTE-NCFWIKVN 406
++ P + M++LNW K+ + E N W ++
Sbjct: 529 PVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLS 588
Query: 407 ENKYENVDL-LCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLS 465
E V+ +E F + +E + + +K+ KE+ FLD+K + NL+IFL
Sbjct: 589 SPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRA--RKEPKEITFLDAKKSLNLNIFLK 646
Query: 466 SFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVV 525
F+ EE+ MI D T+ +++ L+K LP++ ++ +L F E + L + F +
Sbjct: 647 QFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYL 706
Query: 526 VMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGN 585
++ + + R+ +L ++ ++P V ACE + S+ +L+L +GN
Sbjct: 707 LLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGN 766
Query: 586 YMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLD 645
++N GS GF +S+L KL +TKS + TLLH ++E E+ +PD+L DLE
Sbjct: 767 FLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPS 826
Query: 646 KASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLS 705
+A+ +++E + ++L LE E + ++ +++ ++ + + L
Sbjct: 827 QAAGINLEIIRSEASSNLKKL--LETERKVSASVAEVQEQYTERLQASI----SAFRALD 880
Query: 706 KLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRV 765
+L E +E+ + + Y D +++S+ED + + FR F++A+KEN ++E K +R
Sbjct: 881 ELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERR 940
Query: 766 RIAKELAERE-RLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFR 813
+ ++LAE E R R + K + + + +E V+D LL ++ G R
Sbjct: 941 K--QQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLR 987
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 263 bits (671), Expect = 7e-70
Identities = 207/799 (25%), Positives = 387/799 (48%), Gaps = 94/799 (11%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEE-KKIDR 59
MS +++ +A +++ ++P V++LL+AVC+V E +L A + E K++ R
Sbjct: 194 MSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGH--EIILAAFDNFKEVCKELHR 251
Query: 60 FFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCI 117
F ++E R+ +++ VACMQ IN +V S +D++FR+H++ EF + GL+E L +
Sbjct: 252 FEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHT 311
Query: 118 KNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISI 177
+++ L +Q++ + +++F++ LED + N+ V+E E + +
Sbjct: 312 ESEKLQVQIQAY----LDNVFDVGGLLEDAETK--------NVALEKVEEL--EEHVSHL 357
Query: 178 LQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQA 237
+ LL + N+ +R + E Q++ ++
Sbjct: 358 TEKLLDLENENMMR------VAELEKQLLQREKELE------------------------ 387
Query: 238 KLEEFEEKASE-------LYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGA 290
++E E S L K+ E+ F + ++ E+ +E A + + G
Sbjct: 388 SIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGM 447
Query: 291 LPADCNI--PLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVP 348
P+D ++ P PP +E LP PPP P PP PPPPPPLP P
Sbjct: 448 PPSDLDLLAPAPPPEE------VLPLPPP-------PAPPLPPPPPPLPDK-------CP 487
Query: 349 PPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNEN 408
P PPL G S L + ++ KK K + + NW ++P++++ F +E
Sbjct: 488 PAPPLP--GAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEK 545
Query: 409 KYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFR 468
E++DL K E F + + + + K+ +K ++ L++ A+NL+I L
Sbjct: 546 ILEDLDL-DKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAG 604
Query: 469 VPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFVV 525
EEI I D L ++ L++ LP + ++ L Q++ E L ++F++
Sbjct: 605 RSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFML 664
Query: 526 VMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGN 585
+ S V+RL R++ + F F++ + + P + A+ A +K S+ ++LE++L +GN
Sbjct: 665 LFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGN 724
Query: 586 YMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLD 645
YMN+ R A +GF L SL L DTKS D+K TLLHF+ +EKYPD+ NF +L ++
Sbjct: 725 YMNSSKRGA-VYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVE 783
Query: 646 KASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLS 705
KA+ VS+E + +++++GR ++ + +E +HD V + F+ + + + + L
Sbjct: 784 KAAAVSLENVLLDVKELGRGMELIRREC-------SIHDNSV--LRNFLSTNEGKLDKLQ 834
Query: 706 KLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRV 765
+ + E+ Y +++ Y+ K F F ++ +A +EN +++ EE +
Sbjct: 835 RDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREK 894
Query: 766 RIAKELAERERLERQQKKK 784
++A+E + + Q+ K
Sbjct: 895 QLAQEAKKLDAKTPSQRNK 913
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 263 bits (671), Expect = 7e-70
Identities = 207/799 (25%), Positives = 387/799 (48%), Gaps = 94/799 (11%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEE-KKIDR 59
MS +++ +A +++ ++P V++LL+AVC+V E +L A + E K++ R
Sbjct: 245 MSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGH--EIILAAFDNFKEVCKELHR 302
Query: 60 FFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCI 117
F ++E R+ +++ VACMQ IN +V S +D++FR+H++ EF + GL+E L +
Sbjct: 303 FEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHT 362
Query: 118 KNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISI 177
+++ L +Q++ + +++F++ LED + N+ V+E E + +
Sbjct: 363 ESEKLQVQIQAY----LDNVFDVGGLLEDAETK--------NVALEKVEEL--EEHVSHL 408
Query: 178 LQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQA 237
+ LL + N+ +R + E Q++ ++
Sbjct: 409 TEKLLDLENENMMR------VAELEKQLLQREKELE------------------------ 438
Query: 238 KLEEFEEKASE-------LYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGA 290
++E E S L K+ E+ F + ++ E+ +E A + + G
Sbjct: 439 SIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGM 498
Query: 291 LPADCNI--PLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVP 348
P+D ++ P PP +E LP PPP P PP PPPPPPLP P
Sbjct: 499 PPSDLDLLAPAPPPEE------VLPLPPP-------PAPPLPPPPPPLPDK-------CP 538
Query: 349 PPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNEN 408
P PPL G S L + ++ KK K + + NW ++P++++ F +E
Sbjct: 539 PAPPLP--GAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEK 596
Query: 409 KYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFR 468
E++DL K E F + + + + K+ +K ++ L++ A+NL+I L
Sbjct: 597 ILEDLDL-DKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAG 655
Query: 469 VPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFVV 525
EEI I D L ++ L++ LP + ++ L Q++ E L ++F++
Sbjct: 656 RSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFML 715
Query: 526 VMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGN 585
+ S V+RL R++ + F F++ + + P + A+ A +K S+ ++LE++L +GN
Sbjct: 716 LFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGN 775
Query: 586 YMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLD 645
YMN+ R A +GF L SL L DTKS D+K TLLHF+ +EKYPD+ NF +L ++
Sbjct: 776 YMNSSKRGA-VYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVE 834
Query: 646 KASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLS 705
KA+ VS+E + +++++GR ++ + +E +HD V + F+ + + + + L
Sbjct: 835 KAAAVSLENVLLDVKELGRGMELIRREC-------SIHDNSV--LRNFLSTNEGKLDKLQ 885
Query: 706 KLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRV 765
+ + E+ Y +++ Y+ K F F ++ +A +EN +++ EE +
Sbjct: 886 RDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREK 945
Query: 766 RIAKELAERERLERQQKKK 784
++A+E + + Q+ K
Sbjct: 946 QLAQEAKKLDAKTPSQRNK 964
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 248 bits (634), Expect = 1e-65
Identities = 208/829 (25%), Positives = 389/829 (46%), Gaps = 100/829 (12%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKID 58
MS +++ +A +++ ++P V++LL+AVC+V G E IL GE+++ +
Sbjct: 242 MSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFE 301
Query: 59 RFFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKC 116
+ ++E R+ N++ VA MQ IN +V S +D++FR+H++ EF + GL E L LK
Sbjct: 302 K---LMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKH 358
Query: 117 IKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAE------LDEAYDVYNMVWSTVKETRA 170
++D L +Q++ + +++F++ LED + ++E + + + +++T
Sbjct: 359 TESDKLQVQIQAY----LDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTEN 414
Query: 171 EGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFV 230
E + ++ + R + ++ E +++D T RK +
Sbjct: 415 EA-----MSKIVELEKQLMQRNKELDVVRE------IYKDANTQVHTLRKMVK------- 456
Query: 231 DICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGA 290
+ EE ++ S L KK + + Q T +K + I L S
Sbjct: 457 -------EKEEAIQRQSTLEKKIHE--LEKQGTIKIQKKGDGDIAILPVVASGTLSMGSE 507
Query: 291 LPADCNIPLPPSKEGGTGHSALPPPPPLP----------SGGGVPPPPPPPPPPPLPGMR 340
+ A ++ P+ + PPPPPLP +G PP PPPPPPPP P
Sbjct: 508 VVAGNSVG--PTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPP--- 562
Query: 341 MPFSGPVPPPPPLGFLGGQN------SPPLPILP----------------FGLKPKKEFK 378
P P PPPPPL + +PPLP P +K KK K
Sbjct: 563 -PPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIK 621
Query: 379 PEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEE 438
+ M NW+ ++P+++ F +E E+++ + + E F + + + +
Sbjct: 622 TKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLN-VDEFEEIFKTKAQGPAIDLSSSK 680
Query: 439 KKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHL 498
+K +K ++ L++ A+NL+I L +EI I D L ++ L++ L
Sbjct: 681 QKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFL 740
Query: 499 PDQEQLNSLSQFKSE---YSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKP 555
P + ++ L ++ E NL + ++F++ S ++RL +++ + F F E + + P
Sbjct: 741 PTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTP 800
Query: 556 DIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQ 615
+ A+ A IK S+ K+LE++L +GNYMN+ R A +GF L SL L DTKS D+
Sbjct: 801 QLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDR 859
Query: 616 KTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELET 675
K TLLH++ + +EKY + F ++L ++KA+ VS+E + +++++ R + ++E
Sbjct: 860 KQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREY-- 917
Query: 676 FPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFL 735
+HD T + F+++ + + + L + + + ++ Y+ + K F
Sbjct: 918 -----TMHD-HNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFF 971
Query: 736 TDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKK 784
F + QA +EN +++ E+ + ++L E+E L QQ K
Sbjct: 972 PVFVRFVKAYKQAEEENELRKKQEQ-----ALMEKLLEQEALMEQQDPK 1015
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 221 bits (562), Expect = 3e-57
Identities = 225/907 (24%), Positives = 396/907 (43%), Gaps = 157/907 (17%)
Query: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKID 58
M+ ++ +A +++ ++P V++LL+AVC+V G + IL GE+ + +
Sbjct: 248 MNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFE 307
Query: 59 RFFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKC 116
+ ++E R+ +++ VACMQ IN +V S ++++FR+ ++ EF GL L L+
Sbjct: 308 K---LMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRL 364
Query: 117 IKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFIS 176
++D L +Q I+A LD +DV ++ T ET+ +
Sbjct: 365 TESDKLQVQ---------------------IQAYLDNIFDVGALLEDT--ETKN-----A 396
Query: 177 ILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQ 236
+L+H+ + Q+ L+ E + RD + L+ L+Q +
Sbjct: 397 VLEHMEEL-------QEQVALLTERL------RDAENESMAKIAELEKQLSQ------AR 437
Query: 237 AKLEEFEEKASELYKKFEKEFTDHQE-----TQAELQKKEAKINELQAE--LQAFKSQFG 289
+LE E+ SE E E K+ EL+ + ++ +
Sbjct: 438 KELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGD 497
Query: 290 AL-----------PADCNIPLPPSKEGGTGHSALP---------PPPP-----LPS---- 320
A+ P+ + P P G P PPPP LPS
Sbjct: 498 AVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEA 557
Query: 321 ------------GGGVPPP---------PPPPPPPPLPGMRMPFSGPVPPPP-----PLG 354
G PPP PPPPPPPP PG P P PPPP P
Sbjct: 558 PPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPD 617
Query: 355 FLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVD 414
LG ++S P G+K KK + + M LNW+ ++P ++T F +E + +D
Sbjct: 618 ALGRRDSELGP----GVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELD 673
Query: 415 LLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEI 474
+ E F + + + + K+ +K + +++ A+NL+I L + E I
Sbjct: 674 -MSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERI 732
Query: 475 RMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFVVVMSNVK 531
I D L ++ L++ LP + + + +++F+ E L E ++F++ S +
Sbjct: 733 CQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIP 792
Query: 532 RLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGS 591
RL R++ + F F + + P + A+ A IK S ++LE+VL GNYMN+
Sbjct: 793 RLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSK 852
Query: 592 RNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVS 651
R A +GF L SL L + KS D+K TLLH+LV++ EKYP + F DL LDKA VS
Sbjct: 853 RGA-AYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVS 911
Query: 652 VETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENM 711
++++ ++R + R L+ ++E F +D + F+ + + L +
Sbjct: 912 LDSVLADVRSLQRGLELTQRE---FVRQDD-----CMVLKEFLRANSPTMDKLLADSKTA 963
Query: 712 EKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIK-KREAEEKE-------- 762
++ ++S++ Y+ + K S F + + F + +A +E + K+EA +E
Sbjct: 964 QEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGK 1023
Query: 763 ----------KRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAF 812
K R +L L+R+Q+K+ L+ E D G +++++ +++
Sbjct: 1024 GEPPAPKSPPKARRPQMDLI--SELKRRQQKEPLI---YESDRDGAIEDIITVIKTVPFT 1078
Query: 813 RDRRKRT 819
KRT
Sbjct: 1079 ARTGKRT 1085
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 200 bits (509), Expect = 4e-51
Identities = 159/584 (27%), Positives = 264/584 (45%), Gaps = 77/584 (13%)
Query: 259 DHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGH-SALPPPPP 317
DH++ A LQ E + Q L P +IP PP G G S PP PP
Sbjct: 623 DHKDIHAALQPMEGMASNQQKALP---------PPPASIPPPPPLPSGLGSLSPAPPMPP 673
Query: 318 LPSGGGVPPPPPP---------------PPPPPLPGMRMPFS--GPVPPPPPLGFLGGQN 360
+ +G +PPPPPP PPPPPLP P + GP P PPP G
Sbjct: 674 VSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLA---- 729
Query: 361 SPPLPILPFGL-------KPKKEFKPEISMRRLNWLKIRPHEMTENC---FWIKVNENKY 410
PP P L FGL K +P M+ L W +I+ + ++N W + E
Sbjct: 730 PPPPPGLFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDI 789
Query: 411 ENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVP 470
+ L + QQK++ E E+K +KK I K LD K +Q + I +SS +
Sbjct: 790 RDPSEFEYLFSKDTTQQKKKPLSETYEKKNKVKKII---KLLDGKRSQTVGILISSLHLE 846
Query: 471 YEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQF-----KSEYSNLCEPEQFVV 525
++I+ I VD++ + + L ++ +++L + ++ + E L +PEQF+
Sbjct: 847 MKDIQQAIFNVDDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLH 906
Query: 526 VMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGN 585
++ + R I+F+ F E + ++ + ++ A +++ KS +L L+L GN
Sbjct: 907 ELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGN 966
Query: 586 YMNAGSR-NAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPL 644
YMN G+R Q G++L L KLKD KS D L+ ++V+ Y + PL
Sbjct: 967 YMNGGNRTRGQADGYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPL 1026
Query: 645 DK------ASKVSVETLEKNLRQMGRQLQQLEKELETF--PPPEDLHDKFVTKMSRFVIS 696
+ AS+V E L K+LR++ RQL+ EK++ P++ F K+ F
Sbjct: 1027 PEPQDFFLASQVKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQK 1086
Query: 697 AKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVE---------------DFLT----D 737
AK++++ EN +K +++ + Y+ + K E DF T +
Sbjct: 1087 AKKEHKMEESHLENAQKSFETTVRYFGMKPKSGEKEITPSYVFMVWYEFCSDFKTIWKRE 1146
Query: 738 LNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQ 781
N ++ +E++ K +E+K + +I + +ERL +++
Sbjct: 1147 SKNISKERLKMAQESVSKLTSEKKVETKKINPTASLKERLRQKE 1190
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 184 bits (468), Expect = 2e-46
Identities = 132/461 (28%), Positives = 226/461 (49%), Gaps = 49/461 (10%)
Query: 324 VPPPP-PPPPPPPLP------------GMRMP----------FSGPVPPPPPLGFLGGQN 360
+PPPP PPPPPPLP G R P S PVPPPPP
Sbjct: 749 IPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPL----- 803
Query: 361 SPPLPILP----FGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENK-YENVDL 415
PP+P P GL ++ +S++RL W ++ E +E W ++ E+ Y+ +
Sbjct: 804 PPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQV---ENSEGTIWGQLGEDSDYDKLSD 860
Query: 416 LCK---LENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYE 472
+ K LE F Q+ + + + +KK + ++ L K A N SI L+ ++
Sbjct: 861 MVKYLDLELHFGTQKPAK----PVPGPEPFRKK-EVVEILSHKKAYNTSILLAHLKLSPA 915
Query: 473 EIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKR 532
E+R +++ ++ RL + + L+ PD ++ F+ L EP+QFV+ M +V
Sbjct: 916 ELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPE 975
Query: 533 LRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGS- 591
+ RL ++ F+ +E+ I+ + + A E+K S+ +K+LE VL MGNY+N G
Sbjct: 976 YKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQP 1035
Query: 592 RNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVS 651
+ +T GF ++ L +L TK+ D K+T LH L + + +P++L F DL + A+KV+
Sbjct: 1036 KTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVN 1095
Query: 652 VETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKL-HEN 710
L +L + + +++ ++ P + DKF MS F+ +A+ L L E
Sbjct: 1096 QRALTSDLADLHGTISEIQDACQSISPSSE--DKFAMVMSSFLETAQPALRALDGLQREA 1153
Query: 711 MEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKE 751
ME+L ++ + ++ D K + E F F + F +A+ +
Sbjct: 1154 MEELGKA-LAFFGEDSKATTSEAFFGIFAEFMSKFERALSD 1193
Score = 32.0 bits (71), Expect = 2.5
Identities = 30/103 (29%), Positives = 41/103 (39%), Gaps = 15/103 (14%)
Query: 291 LPADCNIPL------PPSKEGGTGHSALPP---PPPLPSGGGVPPPPPPPPPPPLPGMR- 340
LP+ C PL PS +++L P P P G + P PP P P P R
Sbjct: 606 LPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPSRR 665
Query: 341 --MPFSGPVPPPPP---LGFLGGQNSPPLPILPFGLKPKKEFK 378
FS PV L L Q P + I+ L P+ +++
Sbjct: 666 KLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYE 708
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 180 bits (457), Expect = 4e-45
Identities = 153/581 (26%), Positives = 253/581 (43%), Gaps = 103/581 (17%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPP-----PPPPLPGMRMPFSGP----- 346
IP PP G + +PPPPPLP G G+PPPPP P PPPPLPG+ +P P
Sbjct: 1151 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAG 1205
Query: 347 VPPPPPLGFLG------------GQNSPPLPILP-------------------------- 368
+PPPPPL +G G PP P+LP
Sbjct: 1206 IPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPP 1265
Query: 369 ------FGL-------KPKKEFKPEISMRRLNWLKIRPH---EMTENCFWIKVNENKYEN 412
FGL K+ +P M+ L W +I+ H + + + W K+ E +
Sbjct: 1266 PLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSID- 1324
Query: 413 VDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYE 472
C + + ++ I + S K + +K L +K +Q + I +SS + +
Sbjct: 1325 ----CHEFEELFSKTAVKERKKPISDTISKTKAKQVVKLLSNKRSQAVGILMSSLHLDMK 1380
Query: 473 EIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSL------SQFKSEYSNLCEPEQFVVV 526
+I+ ++ +D + + +Q L ++ ++L + S+ K +L +PEQF+
Sbjct: 1381 DIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYE 1440
Query: 527 MSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNY 586
+S + R+ ILF+ F E + +I+ + + CE +K ++L LVL GNY
Sbjct: 1441 LSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNY 1500
Query: 587 MNAGSR-NAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLD 645
MN G++ Q GF L L KLKD KS+D +LL ++V + + L PL
Sbjct: 1501 MNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLP 1560
Query: 646 ------KASKVSVETLEKNLRQMGRQLQQLEKEL-ETFPPPEDLH-DKFVTKMSRFVISA 697
+AS++ E +K+LR++ + L+ E E + + H F M +F+I A
Sbjct: 1561 EPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQA 1620
Query: 698 KEQYETLSKLHENMEKLYQSIIGYY----AIDVKKVSVEDFLTDLNNFRTTFMQAIKENI 753
K E K + Y+ + K+VS F + + F + F
Sbjct: 1621 KIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDF-------- 1672
Query: 754 KKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGD 794
++ +KE ++ + + + E E + RQ+K K L ++K D
Sbjct: 1673 --KDFWKKENKLLLQERVKEAEEVCRQKKGKSLYKIKPRHD 1711
Score = 75.5 bits (184), Expect = 2e-13
Identities = 41/79 (51%), Positives = 46/79 (58%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346
IPLPP G + +PPPPPLP G G+PPPPP PPPPPLPG +P P
Sbjct: 964 IPLPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1018
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1019 IPPPPPLPGAGIPPPPPLP 1037
Score = 73.6 bits (179), Expect = 7e-13
Identities = 40/79 (50%), Positives = 46/79 (58%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346
IP PP G + +PPPPPLP G G+PPPPP PPPPPLPG+ +P P
Sbjct: 1063 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAG 1117
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1118 IPPPPPLPGAGIPPPPPLP 1136
Score = 72.8 bits (177), Expect = 1e-12
Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346
IP PP G + +PPPPPLP G G+PPPPP PPPPPLPG +P P
Sbjct: 997 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1051
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1052 IPPPPPLPGAGIPPPPPLP 1070
Score = 72.8 bits (177), Expect = 1e-12
Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346
IP PP G + +PPPPPLP G G+PPPPP PPPPPLPG +P P
Sbjct: 1030 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1084
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1085 IPPPPPLPGAGIPPPPPLP 1103
Score = 72.8 bits (177), Expect = 1e-12
Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346
IP PP G + +PPPPPLP G G+PPPPP PPPPPLPG +P P
Sbjct: 1074 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAG 1128
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1129 IPPPPPLPGAGIPPPPPLP 1147
Score = 71.6 bits (174), Expect = 3e-12
Identities = 40/79 (50%), Positives = 44/79 (55%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346
IP PP G +PPPPPLP G G+PPPPP PPPPPLPG +P P
Sbjct: 1096 IPPPPPLPG----VGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVG 1150
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1151 IPPPPPLPGAGIPPPPPLP 1169
Score = 70.5 bits (171), Expect = 6e-12
Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346
IP PP G +A+PPPPPLP G G+P PPP PPPPPLPG +P P
Sbjct: 942 IPPPPPLPG----AAIPPPPPLP-GAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 996
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 997 IPPPPPLPGAGIPPPPPLP 1015
Score = 67.4 bits (163), Expect = 5e-11
Identities = 38/79 (48%), Positives = 42/79 (53%), Gaps = 13/79 (16%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPP-----PPPPLPGMRMPFSGP----- 346
IP PP +G LPPPPP G G+PPPPP P P PPLPG +P P
Sbjct: 896 IPQPPPLQGT---EMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAA 952
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 953 IPPPPPLPGAGIPLPPPLP 971
Score = 66.2 bits (160), Expect = 1e-10
Identities = 38/79 (48%), Positives = 44/79 (55%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1041 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1095
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL +G PPLP
Sbjct: 1096 IPPPPPLPGVGIPPPPPLP 1114
Score = 65.9 bits (159), Expect = 2e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1107 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAG 1161
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1162 IPPPPPLPGAGIPPPPPLP 1180
Score = 65.5 bits (158), Expect = 2e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 975 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1029
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1030 IPPPPPLPGAGIPPPPPLP 1048
Score = 65.5 bits (158), Expect = 2e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 986 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1040
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1041 IPPPPPLPGAGIPPPPPLP 1059
Score = 65.5 bits (158), Expect = 2e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1008 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1062
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1063 IPPPPPLPGAGIPPPPPLP 1081
Score = 65.5 bits (158), Expect = 2e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1019 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1073
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1074 IPPPPPLPGAGIPPPPPLP 1092
Score = 65.5 bits (158), Expect = 2e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1052 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVG 1106
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL G PPLP
Sbjct: 1107 IPPPPPLPGAGIPPPPPLP 1125
Score = 65.1 bits (157), Expect = 3e-10
Identities = 38/79 (48%), Positives = 44/79 (55%), Gaps = 15/79 (18%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1085 IPPPPPLPG----AGIPPPPPLP-GVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1139
Query: 347 VPPPPPLGFLGGQNSPPLP 365
+PPPPPL +G PPLP
Sbjct: 1140 IPPPPPLPRVGIPPPPPLP 1158
Score = 63.9 bits (154), Expect = 6e-10
Identities = 38/89 (42%), Positives = 44/89 (49%), Gaps = 23/89 (25%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPSGG----------GVPPPPP-------PPPPPPLPGM 339
+P PP G G +PPPPPLP G G+PPPPP PPPP P G+
Sbjct: 908 LPPPPPPLPGAG---IPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGI 964
Query: 340 RMPFSGP---VPPPPPLGFLGGQNSPPLP 365
+P P +PPPPPL G PPLP
Sbjct: 965 PLPPPLPGAGIPPPPPLPGAGIPPPPPLP 993
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/98 (41%), Positives = 44/98 (44%), Gaps = 29/98 (29%)
Query: 290 ALPADCNIPLPP------SKEGGTGHSALPPPPP---------LPSGGGVPPPPP----- 329
A CNIP PP S G +PPPPP LPS +P PPP
Sbjct: 848 AFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPS-TAIPQPPPLQGTE 906
Query: 330 --PPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLP 365
PPPPPPLPG +PPPPPL G PPLP
Sbjct: 907 MLPPPPPPLPG------AGIPPPPPLPGAGILPLPPLP 938
Score = 61.2 bits (147), Expect = 4e-09
Identities = 38/85 (44%), Positives = 43/85 (50%), Gaps = 16/85 (18%)
Query: 291 LPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPP-------PPPPLPGMRMPF 343
LP +PLPP G +PPPPPLP G +PPPPP P PP P G+ P
Sbjct: 926 LPGAGILPLPPLPGAG-----IPPPPPLP-GAAIPPPPPLPGAGIPLPPPLPGAGIPPPP 979
Query: 344 SGP---VPPPPPLGFLGGQNSPPLP 365
P +PPPPPL G PPLP
Sbjct: 980 PLPGAGIPPPPPLPGAGIPPPPPLP 1004
Score = 51.2 bits (121), Expect = 4e-06
Identities = 29/68 (42%), Positives = 34/68 (50%), Gaps = 6/68 (8%)
Query: 312 LPPPPPLPSGGGVPPPPP----PPPPPPLPGMRMPF--SGPVPPPPPLGFLGGQNSPPLP 365
+P PPPLP P PPPPPPLPGM +P S +P PPPL PP P
Sbjct: 855 IPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPP 914
Query: 366 ILPFGLKP 373
+ G+ P
Sbjct: 915 LPGAGIPP 922
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 179 bits (454), Expect = 1e-44
Identities = 133/485 (27%), Positives = 218/485 (44%), Gaps = 43/485 (8%)
Query: 315 PPPLPSGGGVPPPPPPPPPPPLPGMR--MPFSGPVPPPPPLGFLGGQNSPPLPILPFGLK 372
PPP P PPPPPPPP PP R P S P PPPPPL PP+P P GL
Sbjct: 30 PPPAPP----PPPPPPPPSPPCSCSREECPSSPPPPPPPPL-----PGEPPIPPPPPGLP 80
Query: 373 PKKEFK------PEISMRRLNWLKIRPHEMTE---NCFWIKVNENKYENVDLLCKLENTF 423
P + MR W I P E N + + + + +D +E F
Sbjct: 81 PTTHMNGYSHLGKKKRMRSFFWKTI-PEEQVRGKTNIWTLAARQEHHYQIDTKT-IEELF 138
Query: 424 CCQQ---KERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 480
Q+ K S ++ +E+ LD+K + N+ IFL F+ I I +
Sbjct: 139 GQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQ 198
Query: 481 VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI 540
++ +K LP+ E++ L F + S L + F+ + V R+ A+
Sbjct: 199 GKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAM 258
Query: 541 LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN 600
+ K +F +++ DI + TA +E+ + +L LVL GN MNAG GF
Sbjct: 259 VLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFK 318
Query: 601 LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR 660
LSSL KL DTK+ LLHF+ + ++K +LNF + L + K +++S+E E L
Sbjct: 319 LSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELH 378
Query: 661 QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG 720
+ + + L++ ++ + +M F+ A E+ L + ++ ++I
Sbjct: 379 LLFVRTKSLKENIQR-------DGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLID 431
Query: 721 YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ 780
++ D K + +++ +F T F +A+K+N R A+EL + +RL+ Q
Sbjct: 432 FFCEDKKTMKLDECFQIFRDFCTKFNKAVKDN-----------HDREAQELRQLQRLKEQ 480
Query: 781 QKKKR 785
++K+R
Sbjct: 481 EQKQR 485
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 155 bits (391), Expect = 2e-37
Identities = 119/472 (25%), Positives = 220/472 (46%), Gaps = 46/472 (9%)
Query: 313 PPPPPLPSGGGVPPPPPPP-----PPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPIL 367
PPPPP P+ G+PPPPPPP PPPP+PG + VPPPP G +P
Sbjct: 846 PPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLL-----VPPPPVFNAPQGLGWSQVP-- 898
Query: 368 PFGLKPKKEFKPEISMRRLNWLKIRPHEM----TENC---FWIKVNENKYENVDLLCKLE 420
+ + F + RL W ++RP + C W K+ K + +LE
Sbjct: 899 ----RGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDT----SRLE 950
Query: 421 NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 480
+ F + + +E + +K + K +E+ LDSK + ++I L+ P I++ IL
Sbjct: 951 HLF----ESKSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPP-RTIKIAILN 1005
Query: 481 VDETRLAESMIQNLIKHLPDQEQLNSL--SQFKSEYSNLCEPEQFVVVMSNVKRLRPRLS 538
DE L + I+ ++ +P E+ + +Q + L EQF++ +S++ L RL
Sbjct: 1006 FDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLH 1065
Query: 539 AILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFG 598
FK+ +E + ++ + ++++ +K+ +L +L +GN++N + A
Sbjct: 1066 LWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA---- 1121
Query: 599 FNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKN 658
F LS L K+ + K K +LLH + + E +PD + ++ + +++KV + L+ N
Sbjct: 1122 FELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDN 1181
Query: 659 LRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSI 718
L QM R+ + L+ E + +MS F+ E+ L +H + + S
Sbjct: 1182 LCQMERRCKASWDHLKAIAKHE-MKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSF 1240
Query: 719 I---GYYAIDVKKVSVEDFLTDLNNF----RTTFMQAIKENIKKREAEEKEK 763
+ G+ +++V++ F ++ F RTT + +++ K+ E+ K
Sbjct: 1241 LLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNK 1292
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 139 bits (350), Expect = 1e-32
Identities = 113/480 (23%), Positives = 218/480 (45%), Gaps = 48/480 (10%)
Query: 314 PPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKP 373
P PPLP GVPPPPP PPPPP+ GP PPPPPL P LP +
Sbjct: 572 PSPPLPLLSGVPPPPPLPPPPPI-------KGPFPPPPPL--------PLAAPLPHSVPD 616
Query: 374 KKEFKPEISMRRLNWLKIR---PHEMTENCF------WIKVNENKYENVDLLCKLENTFC 424
+ +L W +++ H ++ + F W ++ + +LE+ F
Sbjct: 617 SSALPTKRKTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSVDT----ARLEHLF- 671
Query: 425 CQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDET 484
E R +E + KK+ + + LD K + ++I L++ P I+ +L DE
Sbjct: 672 ----ESRAKEVLPSKKAGEGRRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEF 726
Query: 485 RLAESMIQNLIKHLPDQEQLNSL--SQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILF 542
+++ I+ L+ +P +E+ + +Q + L E F++ ++++ L RL F
Sbjct: 727 AVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAARLQLWAF 786
Query: 543 KLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLS 602
KL ++ I + + E++ ++ +F +L +L +GN++N +Q+ GF LS
Sbjct: 787 KLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLN----GSQSSGFELS 842
Query: 603 SLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQM 662
L K+ + K ++ +LLH L + + P+ + ++ L + +KV E L +NL Q+
Sbjct: 843 YLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQL 902
Query: 663 GRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSI---I 719
R+ + E+ L + E L +++ F+ + L +H + + + +
Sbjct: 903 ERRSRAAEESLRSLAKHE-LAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYL 961
Query: 720 GYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENI---KKREAEEKEKRVRIAKELAERER 776
GY ++V + F L F + + +E + ++++A +E+ + + E E+
Sbjct: 962 GYTPQAAREVRIMQFCHTLREFALEY-RTCRERVLQQQQKQATYRERNKTRGRMITETEK 1020
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 69.7 bits (169), Expect = 1e-11
Identities = 52/162 (32%), Positives = 70/162 (43%), Gaps = 32/162 (19%)
Query: 236 QAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKS-QFGALPAD 294
Q +LE E E ++ E+E + E + + ++++ ++ Q E + + A PA
Sbjct: 213 QERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPAS 272
Query: 295 CNIPL----------------------PPSKEGGT-GHSALPPPPPLPSGG-----GVPP 326
PL PS++G G A PPPPPLP G +PP
Sbjct: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPP 332
Query: 327 PPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILP 368
PP PPPPPPLP P P PPPPPL PP P P
Sbjct: 333 PPGPPPPPPLPSTGPP---PPPPPPPLPNQVPPPPPPPPAPP 371
Score = 61.6 bits (148), Expect = 3e-09
Identities = 37/85 (43%), Positives = 41/85 (48%), Gaps = 23/85 (27%)
Query: 292 PADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPP 351
PA ++ LPP PPPPPLPS G PPPPPPPPP +P P PPPP
Sbjct: 323 PAQASVALPPPP-------GPPPPPPLPSTG--PPPPPPPPP-------LPNQVPPPPPP 366
Query: 352 PLGFLGGQNSPPLPILPFGLKPKKE 376
P +PPLP F L E
Sbjct: 367 P-------PAPPLPASGFFLASMSE 384
Score = 33.1 bits (74), Expect = 1.1
Identities = 18/49 (36%), Positives = 30/49 (61%)
Query: 747 QAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDE 795
Q KE ++R E+ +R R+ +E ERERLER++ ++ LE + + E
Sbjct: 151 QRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERE 199
Score = 32.3 bits (72), Expect = 1.9
Identities = 12/36 (33%), Positives = 27/36 (75%)
Query: 753 IKKREAEEKEKRVRIAKELAERERLERQQKKKRLLE 788
I++R+ +E++++ + +E ERER+ER++ ++ LE
Sbjct: 142 IQRRQLQEQQRQKELERERLERERMERERLERERLE 177
Score = 31.6 bits (70), Expect = 3.2
Identities = 16/43 (37%), Positives = 30/43 (69%), Gaps = 1/43 (2%)
Query: 749 IKENIKKREAE-EKEKRVRIAKELAERERLERQQKKKRLLEMK 790
++E +++E E E+ +R R+ +E ERERLER++ ++ LE +
Sbjct: 147 LQEQQRQKELERERLERERMERERLERERLERERLERERLEQE 189
Score = 30.8 bits (68), Expect = 5.5
Identities = 12/39 (30%), Positives = 28/39 (71%)
Query: 750 KENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLE 788
+ +++++ +++ +R R+ +E ERERLER++ ++ LE
Sbjct: 144 RRQLQEQQRQKELERERLERERMERERLERERLERERLE 182
Score = 30.0 bits (66), Expect = 9.4
Identities = 19/72 (26%), Positives = 41/72 (56%), Gaps = 5/72 (6%)
Query: 747 QAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEAL 806
+ +++ +RE +E+E++ R+ ++ ERLERQ++ +R + E E + LE L
Sbjct: 184 ERLEQEQLERERQERERQERLERQ----ERLERQERLERQERLDRERQERQERER-LERL 238
Query: 807 QSGAAFRDRRKR 818
+ R+R+++
Sbjct: 239 ERERQERERQEQ 250
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 69.7 bits (169), Expect = 1e-11
Identities = 52/162 (32%), Positives = 70/162 (43%), Gaps = 32/162 (19%)
Query: 236 QAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKS-QFGALPAD 294
Q +LE E E ++ E+E + E + + ++++ ++ Q E + + A PA
Sbjct: 213 QERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPAS 272
Query: 295 CNIPL----------------------PPSKEGGT-GHSALPPPPPLPSGG-----GVPP 326
PL PS++G G A PPPPPLP G +PP
Sbjct: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPP 332
Query: 327 PPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILP 368
PP PPPPPPLP P P PPPPPL PP P P
Sbjct: 333 PPGPPPPPPLPSTGPP---PPPPPPPLPNQVPPPPPPPPAPP 371
Score = 61.6 bits (148), Expect = 3e-09
Identities = 37/85 (43%), Positives = 41/85 (48%), Gaps = 23/85 (27%)
Query: 292 PADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPP 351
PA ++ LPP PPPPPLPS G PPPPPPPPP +P P PPPP
Sbjct: 323 PAQASVALPPPP-------GPPPPPPLPSTG--PPPPPPPPP-------LPNQVPPPPPP 366
Query: 352 PLGFLGGQNSPPLPILPFGLKPKKE 376
P +PPLP F L E
Sbjct: 367 P-------PAPPLPASGFFLASMSE 384
Score = 33.1 bits (74), Expect = 1.1
Identities = 18/49 (36%), Positives = 30/49 (61%)
Query: 747 QAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDE 795
Q KE ++R E+ +R R+ +E ERERLER++ ++ LE + + E
Sbjct: 151 QRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERE 199
Score = 32.3 bits (72), Expect = 1.9
Identities = 12/36 (33%), Positives = 27/36 (75%)
Query: 753 IKKREAEEKEKRVRIAKELAERERLERQQKKKRLLE 788
I++R+ +E++++ + +E ERER+ER++ ++ LE
Sbjct: 142 IQRRQLQEQQRQKELERERLERERMERERLERERLE 177
Score = 31.6 bits (70), Expect = 3.2
Identities = 16/43 (37%), Positives = 30/43 (69%), Gaps = 1/43 (2%)
Query: 749 IKENIKKREAE-EKEKRVRIAKELAERERLERQQKKKRLLEMK 790
++E +++E E E+ +R R+ +E ERERLER++ ++ LE +
Sbjct: 147 LQEQQRQKELERERLERERMERERLERERLERERLERERLEQE 189
Score = 30.8 bits (68), Expect = 5.5
Identities = 12/39 (30%), Positives = 28/39 (71%)
Query: 750 KENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLE 788
+ +++++ +++ +R R+ +E ERERLER++ ++ LE
Sbjct: 144 RRQLQEQQRQKELERERLERERMERERLERERLERERLE 182
Score = 30.0 bits (66), Expect = 9.4
Identities = 19/72 (26%), Positives = 41/72 (56%), Gaps = 5/72 (6%)
Query: 747 QAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEAL 806
+ +++ +RE +E+E++ R+ ++ ERLERQ++ +R + E E + LE L
Sbjct: 184 ERLEQEQLERERQERERQERLERQ----ERLERQERLERQERLDRERQERQERER-LERL 238
Query: 807 QSGAAFRDRRKR 818
+ R+R+++
Sbjct: 239 ERERQERERQEQ 250
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 67.0 bits (162), Expect = 7e-11
Identities = 40/91 (43%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 293 ADCNIPL--PPSKEGGTGHSALPPPPPLPSGGGVPP-PPPPPPPPPLPGMRMPFSGPVPP 349
ADC P+ P S L P PLP G PP PPPPPPPPP PG MP P PP
Sbjct: 654 ADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPP 713
Query: 350 PPPLGFLGGQNSPPLPI-LPFGLKPKKEFKP 379
PPP PP P+ P G+ P P
Sbjct: 714 PPPPPAHPAVTVPPPPLPAPPGVPPPPILPP 744
Score = 62.8 bits (151), Expect = 1e-09
Identities = 37/80 (46%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
Query: 297 IPLPPSKEGGTGHSALPPPPPLPS---GGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPL 353
+PLPP G LPPPPP P G +PPP PPPPPPP P P P P P
Sbjct: 679 LPLPPPP----GFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPP 734
Query: 354 GFLGGQNSPPLPILPFGLKP 373
G PPLP P GL P
Sbjct: 735 GVPPPPILPPLPPFPPGLFP 754
Score = 47.0 bits (110), Expect = 7e-05
Identities = 22/46 (47%), Positives = 26/46 (56%), Gaps = 13/46 (28%)
Query: 314 PPPPLPSGGGVPPPPPPPPPPPLPGMRMPF--------SGPVPPPP 351
PPPPLP P PPPPPPPPP+ ++PF S +PP P
Sbjct: 1539 PPPPLP-----PQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGP 1579
Score = 37.0 bits (84), Expect = 0.077
Identities = 27/71 (38%), Positives = 31/71 (43%), Gaps = 10/71 (14%)
Query: 298 PLPPSKEGGTGHSALPPPP---PLPSGGGVPPPPPP--PPPPPLPGMRMPFSGPVPPPPP 352
PL P + P PP PLP +PPP PP P PPP P S P PP P
Sbjct: 1253 PLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEP-ETTDASHPSVPPEP 1311
Query: 353 LGFLGGQNSPP 363
L ++ PP
Sbjct: 1312 L----AEDHPP 1318
Score = 36.6 bits (83), Expect = 0.10
Identities = 27/86 (31%), Positives = 32/86 (37%), Gaps = 14/86 (16%)
Query: 299 LPPSKEGGTGHSALPP----PPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVP--PPPP 352
LP GGTG S+ PP P + PPP P P P+ PV PPPP
Sbjct: 352 LPFGAVGGTGGSSGPPFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPP 411
Query: 353 LGFLGGQNSPPLPILPFGLKPKKEFK 378
P FG + EF+
Sbjct: 412 --------EEPTATAAFGARDSGEFR 429
Score = 36.6 bits (83), Expect = 0.10
Identities = 23/62 (37%), Positives = 27/62 (43%), Gaps = 12/62 (19%)
Query: 323 GVPPPPPPPPPPPLPGMRMPFSGPVPPPP----PLGFLGGQNSPPLPILPFGLKPKKEFK 378
G+P PPPP PP P P P PPPP L F N P +P G + + E
Sbjct: 1535 GIPAPPPPLPPQPPP--------PPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVT 1586
Query: 379 PE 380
E
Sbjct: 1587 EE 1588
Score = 33.5 bits (75), Expect = 0.85
Identities = 19/51 (37%), Positives = 21/51 (41%), Gaps = 13/51 (25%)
Query: 313 PPPPPLPSGGGV------------PPPPPPPPPPPLPGMRMPFSGPVPPPP 351
PPPP P+ P PPP PP PL P + P PPPP
Sbjct: 408 PPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPL-AKEKPGTPPGPPPP 457
Score = 32.7 bits (73), Expect = 1.5
Identities = 24/72 (33%), Positives = 27/72 (37%), Gaps = 3/72 (4%)
Query: 298 PLPPSKEGGTGHSALPPPPPLPSGGGVPPPP---PPPPPPPLPGMRMPFSGPVPPPPPLG 354
P PP+KE P P P PP P P PPLP R P PP P
Sbjct: 1241 PEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETT 1300
Query: 355 FLGGQNSPPLPI 366
+ PP P+
Sbjct: 1301 DASHPSVPPEPL 1312
Score = 31.6 bits (70), Expect = 3.2
Identities = 26/84 (30%), Positives = 30/84 (35%), Gaps = 17/84 (20%)
Query: 284 FKSQFGALPAD-CNIPLPPSKEGGTG---------HSALPPPPPLPSGGGV----PPPPP 329
FKS F + P PP + T P PPPLP + P PP
Sbjct: 393 FKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKPGTPP 452
Query: 330 PPPPPPLPGMRM---PFSGPVPPP 350
PPPP M + P G P P
Sbjct: 453 GPPPPDTNSMELGGRPTFGWSPEP 476
Score = 31.6 bits (70), Expect = 3.2
Identities = 23/72 (31%), Positives = 25/72 (34%), Gaps = 14/72 (19%)
Query: 292 PADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----------PPPPPPLPGMR 340
PAD P G L P PP PP P P PP LP
Sbjct: 1219 PADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLP--- 1275
Query: 341 MPFSGPVPPPPP 352
+P P+PPP P
Sbjct: 1276 LPLQPPLPPPRP 1287
Score = 31.2 bits (69), Expect = 4.2
Identities = 26/90 (28%), Positives = 38/90 (42%), Gaps = 11/90 (12%)
Query: 257 FTDHQETQAELQKKEAKINELQAELQAFKSQFG--ALPADCNIPLPPSKEGGTGHSALPP 314
F ++ ELQ + + I+ ++L + FG + P P S+ TG + P
Sbjct: 516 FLREPDSDTELQMEGSPISSSSSQLSPL-APFGTNSQPGFRGPTPPSSRPSSTGLEDISP 574
Query: 315 PPPLPSGG-------GVPPPPPPPPPPPLP 337
P LP G+ P PPP P PP P
Sbjct: 575 TP-LPDSDEDEELDLGLGPRPPPEPGPPDP 603
Score = 30.8 bits (68), Expect = 5.5
Identities = 21/62 (33%), Positives = 24/62 (38%), Gaps = 14/62 (22%)
Query: 294 DCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPP-PLPGMRMPFSGPVPPPPP 352
+ IP PP LPP PP P PPPPP P P + + PP P
Sbjct: 1533 NAGIPAPPPP--------LPPQPPPP-----PPPPPVEPTKLPFKELDNQWPSEAIPPGP 1579
Query: 353 LG 354
G
Sbjct: 1580 RG 1581
>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
Length = 502
Score = 63.2 bits (152), Expect = 1e-09
Identities = 30/54 (55%), Positives = 32/54 (59%), Gaps = 6/54 (11%)
Query: 300 PPSKEGGTGHSA-LPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPP 352
PP TG S LPPPPP G +PPPPPPPPPPP G +GP PPP P
Sbjct: 368 PPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSG-----NGPAPPPLP 416
Score = 62.0 bits (149), Expect = 2e-09
Identities = 41/106 (38%), Positives = 43/106 (40%), Gaps = 27/106 (25%)
Query: 297 IPLPPSKEGGTGHSA--------LPPPPPLPSG------GGVPPPPPP---------PPP 333
+P PP G G S + PPPP P G GG PPPPPP PPP
Sbjct: 326 LPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPGRGGPPPPPPPATGRSGPLPPPP 385
Query: 334 PPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKP 379
P G MP P PPPPP N P P LP L P P
Sbjct: 386 PGAGGPPMPPPPPPPPPPP----SSGNGPAPPPLPPALVPAGGLAP 427
Score = 60.8 bits (146), Expect = 5e-09
Identities = 47/138 (34%), Positives = 55/138 (39%), Gaps = 44/138 (31%)
Query: 258 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALP---- 313
++ Q T AE K E Q L+A + + PLPP G + LP
Sbjct: 277 SEAQLTDAETSKLIYDFIEDQGGLEAVRQEMRRQE-----PLPPPPPPSRGGNQLPRPPI 331
Query: 314 -------------------PPPPLPSGGGVPPPP----PPPPPPPLPGMRMPFSGPVPPP 350
PPPP P G PPPP PPPPPPP G SGP+PPP
Sbjct: 332 VGGNKGRSGPLPPVPLGIAPPPPTPRG---PPPPGRGGPPPPPPPATGR----SGPLPPP 384
Query: 351 PPLGFLGGQNSPPLPILP 368
PP G PP+P P
Sbjct: 385 PP-----GAGGPPMPPPP 397
Score = 30.4 bits (67), Expect = 7.2
Identities = 21/58 (36%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 332 PPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWL 389
PPPP P G PP PL G Q PP+ L GL P+I+ R L
Sbjct: 160 PPPPTPANEERRGGL--PPLPLHPGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGL 215
>gi|183396804 Regulation of nuclear pre-mRNA domain containing 2 [Homo
sapiens]
Length = 1461
Score = 62.8 bits (151), Expect = 1e-09
Identities = 33/75 (44%), Positives = 39/75 (52%), Gaps = 3/75 (4%)
Query: 300 PPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPP---PPLPGMRMPFSGPVPPPPPLGFL 356
P +KE H+A PPPP SG P PPPPPPP G +PFS P PPPPP+
Sbjct: 1243 PFTKEAALAHAAPPPPPGEHSGIPFPTPPPPPPPGEHSSSGGSGVPFSTPPPPPPPVDHS 1302
Query: 357 GGQNSPPLPILPFGL 371
G P P+ G+
Sbjct: 1303 GVVPFPAPPLAEHGV 1317
Score = 48.1 bits (113), Expect = 3e-05
Identities = 28/62 (45%), Positives = 30/62 (48%), Gaps = 11/62 (17%)
Query: 298 PLPPSKEGGTGHSALPPPPP-----LPSGGGVPPPPPPPPPPPLPGMRMPFSGPVP-PPP 351
P PP + G PPPPP G GVP PPPPPPP + SG VP P P
Sbjct: 1256 PPPPGEHSGIPFPTPPPPPPPGEHSSSGGSGVPFSTPPPPPPP-----VDHSGVVPFPAP 1310
Query: 352 PL 353
PL
Sbjct: 1311 PL 1312
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 60.5 bits (145), Expect = 7e-09
Identities = 38/96 (39%), Positives = 42/96 (43%), Gaps = 14/96 (14%)
Query: 294 DCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPL 353
D P PP + LPPPP GG PPPPPPPPPP PPPPP
Sbjct: 360 DFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPG------------PPPPPF 407
Query: 354 GFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWL 389
GQ + P P L KPK P +S R + L
Sbjct: 408 TGADGQPAIP-PPLSDTTKPKSSL-PAVSDARSDLL 441
Score = 59.7 bits (143), Expect = 1e-08
Identities = 32/73 (43%), Positives = 37/73 (50%), Gaps = 13/73 (17%)
Query: 301 PSKEGGTGHSALPPPPPL-----PSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGF 355
P + S PP PPL P G PPP PPPPPPP+ G+ PPPPP+GF
Sbjct: 289 PKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGI-------PPPPPPVGF 341
Query: 356 LGGQNSPPLPILP 368
G +PP P P
Sbjct: 342 -GSPGTPPPPSPP 353
Score = 53.5 bits (127), Expect = 8e-07
Identities = 35/99 (35%), Positives = 37/99 (37%), Gaps = 28/99 (28%)
Query: 300 PPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------------------------PPPPP 334
PP + G PPPPP P G PPPPP PPPPP
Sbjct: 309 PPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPP 368
Query: 335 PLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKP 373
P P P +PPPP GG PP P P G P
Sbjct: 369 PPPAADYP---TLPPPPLSQPTGGAPPPPPPPPPPGPPP 404
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/76 (39%), Positives = 32/76 (42%), Gaps = 12/76 (15%)
Query: 298 PLPP--SKEGGTGHSALPPPPPLPSGGGVPPPPPP---PPPPPLPGMRMPFSGPVPPPPP 352
P PP S G A PP PP PPPPP PPPPP G P + P P PP
Sbjct: 302 PAPPLGSPPGPKPGFAPPPAPP-------PPPPPMIGIPPPPPPVGFGSPGTPPPPSPPS 354
Query: 353 LGFLGGQNSPPLPILP 368
+PP P P
Sbjct: 355 FPPHPDFAAPPPPPPP 370
>gi|149944526 additional sex combs like 3 [Homo sapiens]
Length = 2248
Score = 58.5 bits (140), Expect = 2e-08
Identities = 57/194 (29%), Positives = 84/194 (43%), Gaps = 46/194 (23%)
Query: 296 NIPLPPSKE-GGTGHSALPPPPPLPSGGGV-PPPPPPPPPPPLPGMRMPFSGPVPPPPPL 353
N+P+ E GGT H+ +P+ V PPPPPPPPPPP P + P PPPPP
Sbjct: 1993 NMPMKEGDEVGGTAHT-------MPNKALVHPPPPPPPPPPP------PLALPPPPPPP- 2038
Query: 354 GFLGGQNSPPL-PILPFGLKPKKEFKPEISM---RRLNWLKIRPHEMTENCFWIKVNENK 409
PPL P LP P + +P ++M +RL+W + T C IK
Sbjct: 2039 --------PPLPPPLPNAEVPSDQKQPPVTMETTKRLSW-----PQSTGICSNIKSEPLS 2085
Query: 410 YENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRV 469
+E + C+ ++ D E K ++LK K A S LS +
Sbjct: 2086 FEE-------GLSSSCELGMKQVSYDQNEMK------EQLKAFALKSADFSSYLLSEPQK 2132
Query: 470 PYEEIRMMILEVDE 483
P+ ++ ++V +
Sbjct: 2133 PFTQLAAQKMQVQQ 2146
>gi|10937869 survival of motor neuron 2, centromeric isoform d [Homo
sapiens]
Length = 294
Score = 58.2 bits (139), Expect = 3e-08
Identities = 35/99 (35%), Positives = 52/99 (52%), Gaps = 16/99 (16%)
Query: 269 KKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSG------- 321
++ A+ NE ++++ +S+ P + + + P + +S LPPPPP+P
Sbjct: 153 EQNAQENENESQVSTDESENSRSPGNKSDNIKP--KSAPWNSFLPPPPPMPGPRLGPGKP 210
Query: 322 ----GGVPPPPPPPPPPPLPGMRMPF-SGP--VPPPPPL 353
G PPPPPPPPP L PF SGP +PPPPP+
Sbjct: 211 GLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPI 249
Score = 33.5 bits (75), Expect = 0.85
Identities = 29/94 (30%), Positives = 33/94 (35%), Gaps = 21/94 (22%)
Query: 258 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP---PSKEGGTGHSALPP 314
TD E K I A +F LP +P P P K G + PP
Sbjct: 167 TDESENSRSPGNKSDNIKPKSAPWNSF------LPPPPPMPGPRLGPGKPGLKFNGPPPP 220
Query: 315 PPP------------LPSGGGVPPPPPPPPPPPL 336
PPP PSG + PPPPP P L
Sbjct: 221 PPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSL 254
>gi|13259527 survival of motor neuron 2, centromeric isoform a [Homo
sapiens]
Length = 282
Score = 58.2 bits (139), Expect = 3e-08
Identities = 35/99 (35%), Positives = 52/99 (52%), Gaps = 16/99 (16%)
Query: 269 KKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSG------- 321
++ A+ NE ++++ +S+ P + + + P + +S LPPPPP+P
Sbjct: 153 EQNAQENENESQVSTDESENSRSPGNKSDNIKP--KSAPWNSFLPPPPPMPGPRLGPGKP 210
Query: 322 ----GGVPPPPPPPPPPPLPGMRMPF-SGP--VPPPPPL 353
G PPPPPPPPP L PF SGP +PPPPP+
Sbjct: 211 GLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPI 249
Score = 33.5 bits (75), Expect = 0.85
Identities = 29/94 (30%), Positives = 33/94 (35%), Gaps = 21/94 (22%)
Query: 258 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP---PSKEGGTGHSALPP 314
TD E K I A +F LP +P P P K G + PP
Sbjct: 167 TDESENSRSPGNKSDNIKPKSAPWNSF------LPPPPPMPGPRLGPGKPGLKFNGPPPP 220
Query: 315 PPP------------LPSGGGVPPPPPPPPPPPL 336
PPP PSG + PPPPP P L
Sbjct: 221 PPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSL 254
>gi|4507091 survival of motor neuron 1, telomeric isoform d [Homo
sapiens]
Length = 294
Score = 58.2 bits (139), Expect = 3e-08
Identities = 35/99 (35%), Positives = 52/99 (52%), Gaps = 16/99 (16%)
Query: 269 KKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSG------- 321
++ A+ NE ++++ +S+ P + + + P + +S LPPPPP+P
Sbjct: 153 EQNAQENENESQVSTDESENSRSPGNKSDNIKP--KSAPWNSFLPPPPPMPGPRLGPGKP 210
Query: 322 ----GGVPPPPPPPPPPPLPGMRMPF-SGP--VPPPPPL 353
G PPPPPPPPP L PF SGP +PPPPP+
Sbjct: 211 GLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPI 249
Score = 33.5 bits (75), Expect = 0.85
Identities = 29/94 (30%), Positives = 33/94 (35%), Gaps = 21/94 (22%)
Query: 258 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP---PSKEGGTGHSALPP 314
TD E K I A +F LP +P P P K G + PP
Sbjct: 167 TDESENSRSPGNKSDNIKPKSAPWNSF------LPPPPPMPGPRLGPGKPGLKFNGPPPP 220
Query: 315 PPP------------LPSGGGVPPPPPPPPPPPL 336
PPP PSG + PPPPP P L
Sbjct: 221 PPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSL 254
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,081,137
Number of Sequences: 37866
Number of extensions: 2306985
Number of successful extensions: 66664
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1038
Number of HSP's successfully gapped in prelim test: 1146
Number of HSP's that attempted gapping in prelim test: 24038
Number of HSP's gapped (non-prelim): 19824
length of query: 849
length of database: 18,247,518
effective HSP length: 111
effective length of query: 738
effective length of database: 14,044,392
effective search space: 10364761296
effective search space used: 10364761296
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.