Search of human proteins with 32526896

Search of human proteins with 32526896

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32526896 armadillo repeat containing 8 isoform 2 [Homo
sapiens]
         (659 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]   1290   0.0  
gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens]    722   0.0  
gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens]    722   0.0  
gi|224589129 karyopherin 7 [Homo sapiens]                              54   4e-07
gi|4504811 junction plakoglobin [Homo sapiens]                         53   1e-06
gi|12056468 junction plakoglobin [Homo sapiens]                        53   1e-06
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD...    50   5e-06
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD...    50   5e-06
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ...    50   5e-06
gi|4504897 karyopherin alpha 2 [Homo sapiens]                          50   5e-06
gi|34485722 karyopherin alpha 3 [Homo sapiens]                         47   7e-05
gi|4504901 karyopherin alpha 4 [Homo sapiens]                          45   3e-04
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]     44   5e-04
gi|189409124 armadillo repeat containing 3 [Homo sapiens]              42   0.001
gi|222144293 karyopherin alpha 1 [Homo sapiens]                        42   0.002
gi|6912478 karyopherin alpha 6 [Homo sapiens]                          38   0.034
gi|39812229 karyopherin alpha 5 [Homo sapiens]                         37   0.058
gi|11034811 catenin (cadherin-associated protein), delta 2 (neur...    36   0.099
gi|31657114 armadillo repeat containing 4 [Homo sapiens]               36   0.099
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]     34   0.38 
gi|53829376 plakophilin 4 isoform b [Homo sapiens]                     34   0.49 
gi|53829374 plakophilin 4 isoform a [Homo sapiens]                     34   0.49 
gi|239753442 PREDICTED: HEAT repeat containing 7B1 [Homo sapiens]      34   0.49 
gi|239748007 PREDICTED: HEAT repeat containing 7B1 [Homo sapiens]      34   0.49 
gi|148664186 plakophilin 2 isoform 2a [Homo sapiens]                   33   0.64 
gi|194294548 hsp70-interacting protein [Homo sapiens]                  33   0.84 
gi|112363070 hsp70-interacting protein [Homo sapiens]                  33   0.84 
gi|239741905 PREDICTED: HEAT repeat containing 7B1 [Homo sapiens]      33   1.1  
gi|197333755 interferon-related developmental regulator 2 [Homo ...    33   1.1  
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [...    32   1.4  

>gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]
          Length = 659

 Score = 1290 bits (3339), Expect = 0.0
 Identities = 659/659 (100%), Positives = 659/659 (100%)

Query: 1   MEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQET 60
           MEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQET
Sbjct: 1   MEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQET 60

Query: 61  SSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFT 120
           SSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFT
Sbjct: 61  SSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFT 120

Query: 121 SPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIA 180
           SPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIA
Sbjct: 121 SPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIA 180

Query: 181 HLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQL 240
           HLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQL
Sbjct: 181 HLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQL 240

Query: 241 TSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVEL 300
           TSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVEL
Sbjct: 241 TSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVEL 300

Query: 301 QRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDED 360
           QRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDED
Sbjct: 301 QRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDED 360

Query: 361 IRKKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKV 420
           IRKKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKV
Sbjct: 361 IRKKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKV 420

Query: 421 LQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMN 480
           LQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMN
Sbjct: 421 LQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMN 480

Query: 481 MAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGK 540
           MAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGK
Sbjct: 481 MAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGK 540

Query: 541 QIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKL 600
           QIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKL
Sbjct: 541 QIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKL 600

Query: 601 QLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKMALQQYLA 659
           QLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKMALQQYLA
Sbjct: 601 QLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKMALQQYLA 659


>gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens]
          Length = 385

 Score =  722 bits (1863), Expect = 0.0
 Identities = 364/365 (99%), Positives = 365/365 (100%)

Query: 1   MEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQET 60
           MEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQET
Sbjct: 1   MEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQET 60

Query: 61  SSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFT 120
           SSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFT
Sbjct: 61  SSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFT 120

Query: 121 SPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIA 180
           SPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIA
Sbjct: 121 SPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIA 180

Query: 181 HLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQL 240
           HLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQL
Sbjct: 181 HLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQL 240

Query: 241 TSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVEL 300
           TSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVEL
Sbjct: 241 TSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVEL 300

Query: 301 QRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDED 360
           QRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDED
Sbjct: 301 QRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDED 360

Query: 361 IRKKI 365
           IRKK+
Sbjct: 361 IRKKV 365


>gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens]
          Length = 385

 Score =  722 bits (1863), Expect = 0.0
 Identities = 364/365 (99%), Positives = 365/365 (100%)

Query: 1   MEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQET 60
           MEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQET
Sbjct: 1   MEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQET 60

Query: 61  SSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFT 120
           SSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFT
Sbjct: 61  SSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFT 120

Query: 121 SPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIA 180
           SPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIA
Sbjct: 121 SPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIA 180

Query: 181 HLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQL 240
           HLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQL
Sbjct: 181 HLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQL 240

Query: 241 TSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVEL 300
           TSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVEL
Sbjct: 241 TSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVEL 300

Query: 301 QRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDED 360
           QRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDED
Sbjct: 301 QRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDED 360

Query: 361 IRKKI 365
           IRKK+
Sbjct: 361 IRKKV 365


>gi|224589129 karyopherin 7 [Homo sapiens]
          Length = 516

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 52/229 (22%), Positives = 102/229 (44%), Gaps = 9/229 (3%)

Query: 432 ASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKA 491
           A+  L N+    S     ++E GA++ L  L  S N A+    +WAL N+A    +  + 
Sbjct: 134 AAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPE-FRD 192

Query: 492 DILRSLSTEQLFRLLSDS-DLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLIL 550
           +++ S +   L  L+S +  +  L      L NL   +        T  KQI+ A+  +L
Sbjct: 193 NVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYP--CDTAVKQILPALLHLL 250

Query: 551 EGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCISN 610
           + + + EV       L+ + DG+  +   + N  +L ++   M  S + +   ++  + N
Sbjct: 251 QHQDS-EVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGN 309

Query: 611 LIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKMALQQYLA 659
           ++     G+ E+     D G++++L +L Q    ++  +A  AL    A
Sbjct: 310 IV----TGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 354



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 39/171 (22%), Positives = 76/171 (44%), Gaps = 8/171 (4%)

Query: 35  GNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIP 94
           G+NK+   ++  G +PRL+ L+   +S   + T     +G++  GT+   +  +D  ++ 
Sbjct: 271 GSNKRIGQVVNTGVLPRLVVLM--TSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLN 328

Query: 95  ALLQGLLSPDLKFIEACLRCLRTIFTSPVTP-EELLYTDATVIPHLMALLSRSRY--TQE 151
            L Q L        +     L  +   P    ++LL  D  V+P L+ALL    +   +E
Sbjct: 329 VLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYD--VLPPLVALLKNGEFKVQKE 386

Query: 152 YICQIFSHCCKGPDHQTI-LFNHGAVQNIAHLLTSLSYKVRMQALKCFSVL 201
            +  + +        Q I L + G ++ + +LLT+   K+ +  L   S +
Sbjct: 387 AVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCI 437



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 40/214 (18%), Positives = 89/214 (41%), Gaps = 14/214 (6%)

Query: 416 PLMKVLQNAPD-EILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNG 474
           P + VL  + +  +L  +   + N++       +  +++G + +L  L Q   P+++   
Sbjct: 286 PRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEA 345

Query: 475 IWALMNMA----FQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPH 530
            WAL N+A       +Q +  D+L       L  LL + +  V  + + ++ N  +    
Sbjct: 346 AWALSNVAAGPCHHIQQLLAYDVL-----PPLVALLKNGEFKVQKEAVWMVANFATGATM 400

Query: 531 IDKIMSTHGKQIMQAVTLILEGEHNIE--VKEQTLCILANIADGTTAKDLIMTNDDI--L 586
              I   H   +   V L+   +  I   + +   CIL      +  ++L +  +++  +
Sbjct: 401 DQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGI 460

Query: 587 QKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQ 620
            +I+    H + ++  +A+  I      EE+ SQ
Sbjct: 461 DRIEALQLHENRQIGQSALNIIEKHFGEEEDESQ 494


>gi|4504811 junction plakoglobin [Homo sapiens]
          Length = 745

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 45/207 (21%), Positives = 92/207 (44%), Gaps = 5/207 (2%)

Query: 363 KKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQ 422
           K  +   + + ++V  L++++ K       CL  L+   Q+ +     +   + L+++++
Sbjct: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320

Query: 423 NAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMA 482
           N   E L+  +S +  +L     +K  I+E+G ++ L     S +P L  N +W L N++
Sbjct: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380

Query: 483 FQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQI 542
             A ++   + +  +   Q    LS  D+NVL    G L NL       +K + T    +
Sbjct: 381 DVATKQEGLESVLKILVNQ----LSVDDVNVLTCATGTLSNLTCNNSK-NKTLVTQNSGV 435

Query: 543 MQAVTLILEGEHNIEVKEQTLCILANI 569
              +  IL      ++ E  +C L ++
Sbjct: 436 EALIHAILRAGDKDDITEPAVCALRHL 462



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 78/376 (20%), Positives = 160/376 (42%), Gaps = 36/376 (9%)

Query: 279 LLEERVEGAET-LAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDL 337
           LL  +VEG  T L  L EP    Q + S   HLI    D      +  A+ ++ +L +D 
Sbjct: 101 LLATQVEGQATNLQRLAEPS---QLLKSAIVHLINYQDDA---ELATRALPELTKLLNDE 154

Query: 338 KHAHELRQAAFKLYASLGANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRC---- 393
                 + A   +  +  +  E  R+ ++ +  ++  +V  +  +S    L   RC    
Sbjct: 155 DPVVVTKAA---MIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTS---DLDTARCTTSI 208

Query: 394 LHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILES 453
           LH+LS   + L   F+   +   L+++L +  + +L  A + L NLLL    +K  +  +
Sbjct: 209 LHNLSHHREGLLAIFKSGGI-PALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267

Query: 454 GAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNV 513
             ++ +  L    NP         L  +A+   Q+ K  IL +   + L +++ +     
Sbjct: 268 DGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGGPQALVQIMRNYSYEK 326

Query: 514 LMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEH----NIEVKEQTLCILANI 569
           L+ T   +  +LS  P       ++   I++A  +   G+H    +  + +  L  L N+
Sbjct: 327 LLWTTSRVLKVLSVCP-------SNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNL 379

Query: 570 ADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDM 629
           +D  T ++ +   + +L+ +   +    V +   A   +SNL  N    S+ +    ++ 
Sbjct: 380 SDVATKQEGL---ESVLKILVNQLSVDDVNVLTCATGTLSNLTCN---NSKNKTLVTQNS 433

Query: 630 GIVDILHKLSQSPDSN 645
           G+  ++H + ++ D +
Sbjct: 434 GVEALIHAILRAGDKD 449


>gi|12056468 junction plakoglobin [Homo sapiens]
          Length = 745

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 45/207 (21%), Positives = 92/207 (44%), Gaps = 5/207 (2%)

Query: 363 KKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQ 422
           K  +   + + ++V  L++++ K       CL  L+   Q+ +     +   + L+++++
Sbjct: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320

Query: 423 NAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMA 482
           N   E L+  +S +  +L     +K  I+E+G ++ L     S +P L  N +W L N++
Sbjct: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380

Query: 483 FQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQI 542
             A ++   + +  +   Q    LS  D+NVL    G L NL       +K + T    +
Sbjct: 381 DVATKQEGLESVLKILVNQ----LSVDDVNVLTCATGTLSNLTCNNSK-NKTLVTQNSGV 435

Query: 543 MQAVTLILEGEHNIEVKEQTLCILANI 569
              +  IL      ++ E  +C L ++
Sbjct: 436 EALIHAILRAGDKDDITEPAVCALRHL 462



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 78/376 (20%), Positives = 160/376 (42%), Gaps = 36/376 (9%)

Query: 279 LLEERVEGAET-LAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDL 337
           LL  +VEG  T L  L EP    Q + S   HLI    D      +  A+ ++ +L +D 
Sbjct: 101 LLATQVEGQATNLQRLAEPS---QLLKSAIVHLINYQDDA---ELATRALPELTKLLNDE 154

Query: 338 KHAHELRQAAFKLYASLGANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRC---- 393
                 + A   +  +  +  E  R+ ++ +  ++  +V  +  +S    L   RC    
Sbjct: 155 DPVVVTKAA---MIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTS---DLDTARCTTSI 208

Query: 394 LHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILES 453
           LH+LS   + L   F+   +   L+++L +  + +L  A + L NLLL    +K  +  +
Sbjct: 209 LHNLSHHREGLLAIFKSGGI-PALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267

Query: 454 GAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNV 513
             ++ +  L    NP         L  +A+   Q+ K  IL +   + L +++ +     
Sbjct: 268 DGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGGPQALVQIMRNYSYEK 326

Query: 514 LMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEH----NIEVKEQTLCILANI 569
           L+ T   +  +LS  P       ++   I++A  +   G+H    +  + +  L  L N+
Sbjct: 327 LLWTTSRVLKVLSVCP-------SNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNL 379

Query: 570 ADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDM 629
           +D  T ++ +   + +L+ +   +    V +   A   +SNL  N    S+ +    ++ 
Sbjct: 380 SDVATKQEGL---ESVLKILVNQLSVDDVNVLTCATGTLSNLTCN---NSKNKTLVTQNS 433

Query: 630 GIVDILHKLSQSPDSN 645
           G+  ++H + ++ D +
Sbjct: 434 GVEALIHAILRAGDKD 449


>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 56/253 (22%), Positives = 110/253 (43%), Gaps = 9/253 (3%)

Query: 363 KKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQ 422
           K  +     + ++V  L++++VK       CL  L+   Q+ +         + L+ +++
Sbjct: 270 KMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMR 329

Query: 423 NAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMA 482
               E L+  +S +  +L   S +K  I+E+G ++ L       +  L  N +W L N++
Sbjct: 330 TYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLS 389

Query: 483 FQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQI 542
             A ++   + L  L T  L +LL   D+NV+    G+L N L+   + +K+M      I
Sbjct: 390 DAATKQEGMEGL--LGT--LVQLLGSDDINVVTCAAGILSN-LTCNNYKNKMMVCQVGGI 444

Query: 543 MQAVTLILEGEHNIEVKEQTLCILANIA----DGTTAKDLIMTNDDILQKIKYYMGHSHV 598
              V  +L      ++ E  +C L ++     +   A++ +  +  +   +K     SH 
Sbjct: 445 EALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHW 504

Query: 599 KLQLAAMFCISNL 611
            L  A +  I NL
Sbjct: 505 PLIKATVGLIRNL 517


>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 56/253 (22%), Positives = 110/253 (43%), Gaps = 9/253 (3%)

Query: 363 KKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQ 422
           K  +     + ++V  L++++VK       CL  L+   Q+ +         + L+ +++
Sbjct: 270 KMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMR 329

Query: 423 NAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMA 482
               E L+  +S +  +L   S +K  I+E+G ++ L       +  L  N +W L N++
Sbjct: 330 TYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLS 389

Query: 483 FQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQI 542
             A ++   + L  L T  L +LL   D+NV+    G+L N L+   + +K+M      I
Sbjct: 390 DAATKQEGMEGL--LGT--LVQLLGSDDINVVTCAAGILSN-LTCNNYKNKMMVCQVGGI 444

Query: 543 MQAVTLILEGEHNIEVKEQTLCILANIA----DGTTAKDLIMTNDDILQKIKYYMGHSHV 598
              V  +L      ++ E  +C L ++     +   A++ +  +  +   +K     SH 
Sbjct: 445 EALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHW 504

Query: 599 KLQLAAMFCISNL 611
            L  A +  I NL
Sbjct: 505 PLIKATVGLIRNL 517


>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 56/253 (22%), Positives = 110/253 (43%), Gaps = 9/253 (3%)

Query: 363 KKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQ 422
           K  +     + ++V  L++++VK       CL  L+   Q+ +         + L+ +++
Sbjct: 270 KMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMR 329

Query: 423 NAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMA 482
               E L+  +S +  +L   S +K  I+E+G ++ L       +  L  N +W L N++
Sbjct: 330 TYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLS 389

Query: 483 FQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQI 542
             A ++   + L  L T  L +LL   D+NV+    G+L N L+   + +K+M      I
Sbjct: 390 DAATKQEGMEGL--LGT--LVQLLGSDDINVVTCAAGILSN-LTCNNYKNKMMVCQVGGI 444

Query: 543 MQAVTLILEGEHNIEVKEQTLCILANIA----DGTTAKDLIMTNDDILQKIKYYMGHSHV 598
              V  +L      ++ E  +C L ++     +   A++ +  +  +   +K     SH 
Sbjct: 445 EALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHW 504

Query: 599 KLQLAAMFCISNL 611
            L  A +  I NL
Sbjct: 505 PLIKATVGLIRNL 517


>gi|4504897 karyopherin alpha 2 [Homo sapiens]
          Length = 529

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 63/301 (20%), Positives = 126/301 (41%), Gaps = 27/301 (8%)

Query: 372 MDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPD--EIL 429
           +D IV G++ S+V+ +L A +    L    +Q        A   P         D   I 
Sbjct: 78  VDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQ 137

Query: 430 VVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKI 489
             ++  L N+    S   + +++ GA+     L  S +  +    +WAL N+A   +  +
Sbjct: 138 FESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA--GDGSV 195

Query: 490 KAD-ILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLST----------RPHIDKIMSTH 538
             D +++  + + L  LL+  D++ L    G LRNL  T           P ID +    
Sbjct: 196 FRDLVIKYGAVDPLLALLAVPDMSSL--ACGYLRNLTWTLSNLCRNKNPAPPIDAV---- 249

Query: 539 GKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHV 598
            +QI+  +  +L  + + EV   T   ++ + DG   +  ++    ++ ++   +G S +
Sbjct: 250 -EQILPTLVRLLHHD-DPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASEL 307

Query: 599 KLQLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKMALQQYL 658
            +   A+  I N++     G+ E+   + D G + +   L  +P +N+  +A   +    
Sbjct: 308 PIVTPALRAIGNIV----TGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT 363

Query: 659 A 659
           A
Sbjct: 364 A 364



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 30/103 (29%), Positives = 49/103 (47%), Gaps = 2/103 (1%)

Query: 42  NLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLL 101
           N+I  G +P+ +  L + T  + ++ E A  L ++A GT    K+++D   IPA +  L 
Sbjct: 114 NIIRAGLIPKFVSFLGR-TDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLA 172

Query: 102 SPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLS 144
           SP     E  +  L  I        +L+     V P L+ALL+
Sbjct: 173 SPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDP-LLALLA 214



 Score = 33.5 bits (75), Expect = 0.64
 Identities = 28/115 (24%), Positives = 56/115 (48%), Gaps = 4/115 (3%)

Query: 31  NAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDC 90
           N V G ++Q   +I  GA+     LL      T ++ E    + ++  G ++ ++ +++ 
Sbjct: 319 NIVTGTDEQTQVVIDAGALAVFPSLLTNP--KTNIQKEATWTMSNITAGRQDQIQQVVNH 376

Query: 91  HIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLY-TDATVIPHLMALLS 144
            ++P L+  L   D K  +  +  + T +TS  T E+++Y     +I  LM LL+
Sbjct: 377 GLVPFLVSVLSKADFKTQKEAVWAV-TNYTSGGTVEQIVYLVHCGIIEPLMNLLT 430


>gi|34485722 karyopherin alpha 3 [Homo sapiens]
          Length = 521

 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 47/224 (20%), Positives = 96/224 (42%), Gaps = 12/224 (5%)

Query: 417 LMKVLQNAPDEILVVASSMLCNLLLEFSPSKEP----ILESGAVELLCG-LTQSENPALR 471
           L  +LQNA  +  VV  S +       S  + P    +++SG + +L   L + +NP+L+
Sbjct: 73  LEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQ 132

Query: 472 VNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHI 531
               WAL N+A     + +A +++S +     RLL     NV  + +  L N++   P  
Sbjct: 133 FEAAWALTNIASGTSAQTQA-VVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQC 191

Query: 532 DKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKY 591
              + + G  +++ +   +     I        ++ N+         + T  +IL  +  
Sbjct: 192 RDYVISLG--VVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCV 249

Query: 592 YMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDIL 635
            + H+ + + +  ++ +S L     +G  E+   + D G+V  L
Sbjct: 250 LIYHTDINILVDTVWALSYL----TDGGNEQIQMVIDSGVVPFL 289



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 52/243 (21%), Positives = 112/243 (46%), Gaps = 17/243 (6%)

Query: 403 QLRTSFQDHAVWKPL-MKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCG 461
           Q +   Q +AV  PL +++L++    +   A   L N++ +    ++ ++  G V+ L  
Sbjct: 149 QTQAVVQSNAV--PLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLS 206

Query: 462 LTQSENPALRVNGI-WALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGL 520
                 P   +  + W ++N+    +     + ++ +    L  L+  +D+N+L+ T+  
Sbjct: 207 FISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEI-LPALCVLIYHTDINILVDTVWA 265

Query: 521 LRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILA--NIADGTTAKDL 578
           L  L  T    ++I       ++  +  +L  +   EVK QT  + A  NI  GT  +  
Sbjct: 266 LSYL--TDGGNEQIQMVIDSGVVPFLVPLLSHQ---EVKVQTAALRAVGNIVTGTDEQTQ 320

Query: 579 IMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDMGIVD-ILHK 637
           ++ N D+L      + H   K+   A++ +SN+      G+Q++   + D G++  I+H+
Sbjct: 321 VVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNI----TAGNQQQVQAVIDAGLIPMIIHQ 376

Query: 638 LSQ 640
           L++
Sbjct: 377 LAK 379



 Score = 33.1 bits (74), Expect = 0.84
 Identities = 27/114 (23%), Positives = 53/114 (46%), Gaps = 3/114 (2%)

Query: 35  GNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIP 94
           G N+Q   +I  G VP L+ LL  +    +++T     +G++  GT+   + +L+C ++ 
Sbjct: 272 GGNEQIQMVIDSGVVPFLVPLLSHQ--EVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLS 329

Query: 95  ALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRY 148
                L  P  K  +  +  L  I T+    +     DA +IP ++  L++  +
Sbjct: 330 HFPNLLSHPKEKINKEAVWFLSNI-TAGNQQQVQAVIDAGLIPMIIHQLAKGDF 382



 Score = 29.6 bits (65), Expect = 9.2
 Identities = 30/140 (21%), Positives = 65/140 (46%), Gaps = 9/140 (6%)

Query: 495 RSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLST--RPHIDKIMSTHGKQIMQAVTLILEG 552
           ++++ E + +  +  +  V +  +   R LLS+   P ID ++ +    I+  +   LE 
Sbjct: 69  QNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSG---ILPILVKCLER 125

Query: 553 EHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLI 612
           + N  ++ +    L NIA GT+A+   +   + +      +   H  +   A++ + N+I
Sbjct: 126 DDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNII 185

Query: 613 WNEEEGSQERQDKLRDMGIV 632
               +G Q R D +  +G+V
Sbjct: 186 ---GDGPQCR-DYVISLGVV 201


>gi|4504901 karyopherin alpha 4 [Homo sapiens]
          Length = 521

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 67/311 (21%), Positives = 124/311 (39%), Gaps = 20/311 (6%)

Query: 13  RLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIV-LGAVPRLLYLLQQETSSTELKTECAV 71
           RL     Q V +  +     +IG+  Q  + ++ LG V  LL  +      T L+    V
Sbjct: 164 RLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWV 223

Query: 72  VLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYT 131
           ++ +L    +          I+PAL   +   D+  +   +  L +  T     +  +  
Sbjct: 224 MV-NLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWAL-SYLTDAGNEQIQMVI 281

Query: 132 DATVIPHLMALLSRSRY-TQEYICQIFSHCCKGPDHQT-ILFNHGAVQNIAHLLTSLSYK 189
           D+ ++PHL+ LLS      Q    +   +   G D QT ++ N  A+ +   LLT    K
Sbjct: 282 DSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEK 341

Query: 190 VRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSA------ 243
           +  +A+   S +   N Q     V  ++D  L+P I   + + D   + +   A      
Sbjct: 342 INKEAVWFLSNITAGNQQ----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTI 397

Query: 244 ----KCLTYMCRAGAIRTDDNCIVLKTLPCL-VRMCSKERLLEERVEGAETLAYLIEPDV 298
                 + Y+ +   I    N + +K    + V +     +L+   + AET+  LIE   
Sbjct: 398 SGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECG 457

Query: 299 ELQRIASITDH 309
            L++I  + +H
Sbjct: 458 GLEKIEQLQNH 468



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 39/219 (17%), Positives = 91/219 (41%), Gaps = 44/219 (20%)

Query: 444 SPSKEPILESGAVELLCG-LTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQL 502
           +P  + +++SG + +L   L + +NP+L+    WAL N+A    ++ +A +++S +    
Sbjct: 104 NPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQA-VVQSNAVPLF 162

Query: 503 FRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHG----------------------- 539
            RLL     NV  + +  L N++   P     + + G                       
Sbjct: 163 LRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTW 222

Query: 540 ------------------KQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIMT 581
                             ++I+ A+ +++    ++ +   T+  L+ + D    +  ++ 
Sbjct: 223 VMVNLCRHKDPPPPMETIQEILPALCVLIH-HTDVNILVDTVWALSYLTDAGNEQIQMVI 281

Query: 582 NDDILQKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQ 620
           +  I+  +   + H  VK+Q AA+  + N++   +E +Q
Sbjct: 282 DSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQ 320


>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
          Length = 493

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 39/154 (25%), Positives = 68/154 (44%), Gaps = 3/154 (1%)

Query: 355 GANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVW 414
           G    + ++  I  E  M  +V  L+ +   ++L A RCLH LS S +Q   +       
Sbjct: 93  GLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLEAARCLHELSHS-EQSTVAEACLPAT 151

Query: 415 KPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNG 474
             L+  L +   + + +    L NL++E    +  +L  G V  L    QS + A+    
Sbjct: 152 SYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQSPHVAVLEAL 211

Query: 475 IWALMNM--AFQAEQKIKADILRSLSTEQLFRLL 506
            +AL  +  A +A +KI   IL S   + + ++L
Sbjct: 212 GYALSQLLQAEEAPEKIIPSILASTLPQHMLQML 245



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 37/150 (24%), Positives = 66/150 (44%), Gaps = 7/150 (4%)

Query: 49  VPRLLYLLQQETS-STELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKF 107
           +P   YLL   +S S++    C   LG+L + +E   + LL   I+PAL   + SP +  
Sbjct: 148 LPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQSPHVAV 207

Query: 108 IEACLRCLRTIFTSPVTPEELL--YTDATVIPHLMALLSRSRYTQEYICQIFSHCCK--- 162
           +EA    L  +  +   PE+++     +T+  H++ +L         +   F+ C     
Sbjct: 208 LEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQMLQPGPKLNPGVAVEFAWCLHYII 267

Query: 163 -GPDHQTILFNHGAVQNIAHLLTSLSYKVR 191
                  +L  HGA+  +  LL  L+  V+
Sbjct: 268 CSQVSNPLLIGHGALSTLGLLLLDLAGAVQ 297


>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
          Length = 872

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 98/513 (19%), Positives = 195/513 (38%), Gaps = 56/513 (10%)

Query: 156 IFSHCCKGPDHQTILFNHGAVQNIAHLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNV 215
           I+    KG +++T L   GAV+ +  LLT     VR  A   F +LA  N      +  +
Sbjct: 49  IYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNN-----DVKKL 103

Query: 216 LVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCS 275
           L + +++  +  ++   ++ +  +  S  CL  M  +    +         L  L+R+ S
Sbjct: 104 LRELDVMNSVIAQLAPEEEVVIHEFASL-CLANM--SAEYTSKVQIFEHGGLEPLIRLLS 160

Query: 276 K--ERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADY--------------FK 319
                + +  +E    L    +   +LQ + +I   L  + ++Y                
Sbjct: 161 SPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIAN 220

Query: 320 YPSSVSAITDIKRLDH-----DLKHAHELRQAAFKLYASLGANDEDIRKKIIETENMMDR 374
              S + + D + LDH     + K  ++L   A  + A+    D D   +I +T  +   
Sbjct: 221 DKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANC-LEDMDTMVQIQQTGGLKKL 279

Query: 375 IVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASS 434
           +    + +   ++  A + +   +   +  R  F +  V K L+ +L +  D   + AS 
Sbjct: 280 LSFAENSTIPDIQKNAAKAITKAAYDPEN-RKLFHEQEVEKCLVALLGSENDGTKIAASQ 338

Query: 435 MLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMA----FQAEQKIK 490
            + + + E S SK+     G  +L+  L +S+N  +R     AL N+       A    +
Sbjct: 339 AI-SAMCENSGSKDFFNNQGIPQLI-QLLKSDNEEVREAAALALANLTTCNPANANAAAE 396

Query: 491 ADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLIL 550
           AD       + L  LLS      +     +L N+    P     ++     IM A+   L
Sbjct: 397 AD-----GIDPLINLLSSKRDGAIANAATVLTNMAMQEP---LRLNIQNHDIMHAIISPL 448

Query: 551 EGEHNIEVKEQTLCILANIADGTTAKDLIMTN--DDILQKIKYYMGHSHVKLQLAAMFCI 608
              + +   +  L + A   D     +L  +   + +++ ++            A M C 
Sbjct: 449 RSANTVVQSKAALAVTATACDVEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVC- 507

Query: 609 SNLIWNEEEGSQERQDKLRDMGIVDILHKLSQS 641
                    G +   ++L  +G +DIL +++ S
Sbjct: 508 --------AGDELTANELCRLGALDILEEVNVS 532



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 100/468 (21%), Positives = 188/468 (40%), Gaps = 46/468 (9%)

Query: 38  KQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALL 97
           + K  L+ LGAV  L  LL  E     ++    ++ G LA  + N+VK LL    +   +
Sbjct: 58  ENKTTLLELGAVEPLTKLLTHEDKI--VRRNATMIFGILA--SNNDVKKLLRELDVMNSV 113

Query: 98  QGLLSPDLK-----FIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEY 152
              L+P+ +     F   CL  +   +TS V     ++    + P +  L S     ++ 
Sbjct: 114 IAQLAPEEEVVIHEFASLCLANMSAEYTSKVQ----IFEHGGLEPLIRLLSSPDPDVKKN 169

Query: 153 ICQIFSHCCKGPDHQTILFNHGAVQNIAHLLTSLSYKVRMQALKCFSVLAFENPQVSMTL 212
             +   +  +    +  L    A+  I  LL S    +++ ALK   V+A +    +M  
Sbjct: 170 SMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLR 229

Query: 213 VNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMC------RAGAIRTDDNCIVLKT 266
            N  +D  L+  +  K L  D  IE     A CL  M       + G ++   +     T
Sbjct: 230 DNQGLD-HLIKILETKELN-DLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENST 287

Query: 267 LPCLVRMCSK----------ERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLA- 315
           +P + +  +K           R L    E  + L  L+  + +  +IA+ +  + AM   
Sbjct: 288 IPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAA-SQAISAMCEN 346

Query: 316 ----DYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIETENM 371
               D+F     +  +  + + D++     E+R+AA    A+L   +        E + +
Sbjct: 347 SGSKDFFNN-QGIPQLIQLLKSDNE-----EVREAAALALANLTTCNPANANAAAEADGI 400

Query: 372 MDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVV 431
            D ++  LS         A   L +++   + LR + Q+H +   ++  L++A   +   
Sbjct: 401 -DPLINLLSSKRDGAIANAATVLTNMAMQ-EPLRLNIQNHDIMHAIISPLRSANTVVQSK 458

Query: 432 ASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALM 479
           A+  +     +     E +  SG +E L  L +S+N  +R +  WA+M
Sbjct: 459 AALAVTATACDVEARTE-LRNSGGLEPLVELLRSKNDEVRKHASWAVM 505


>gi|222144293 karyopherin alpha 1 [Homo sapiens]
          Length = 538

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 62/279 (22%), Positives = 107/279 (38%), Gaps = 54/279 (19%)

Query: 29  MKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLL 88
           + N   GN+ Q   +I  GAVP  + LL  E    +++ +    LG++A  +      +L
Sbjct: 151 LTNIASGNSLQTRIVIQAGAVPIFIELLSSEFE--DVQEQAVWALGNIAGDSTMCRDYVL 208

Query: 89  DCHIIPALLQGLLS-------------------------PDLKFIEACLRCLR-TIFTSP 122
           DC+I+P LLQ L S                         P+   +  CL  L   +F S 
Sbjct: 209 DCNILPPLLQ-LFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSD 267

Query: 123 VT---------------PEELLYT--DATVIPHLMALLSRSRY-TQEYICQIFSHCCKGP 164
                            P + +    DA V   L+ LL  + Y       +   +   G 
Sbjct: 268 TDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGD 327

Query: 165 DHQT-ILFNHGAVQNIAHLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLP 223
           D QT ++ N  A+Q++ HLL+S    ++ +A    S +   N     T+++  +   L+ 
Sbjct: 328 DIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALIS 387

Query: 224 QIFVKMLQRDKPIEMQLT------SAKCLTYMCRAGAIR 256
            +     +  K     +T      SA+ + Y+   G I+
Sbjct: 388 ILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIK 426



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 44/217 (20%), Positives = 91/217 (41%), Gaps = 20/217 (9%)

Query: 435 MLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQA----EQKIK 490
           +L N+    S     ++++GAV +   L  SE   ++   +WAL N+A  +    +  + 
Sbjct: 150 VLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLD 209

Query: 491 ADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLL---STRPHIDKIMSTHGKQIMQAVT 547
            +IL  L   QLF     + L +    +  L NL    S  P   K+        +  ++
Sbjct: 210 CNILPPLL--QLFS--KQNRLTMTRNAVWALSNLCRGKSPPPEFAKV-----SPCLNVLS 260

Query: 548 LILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFC 607
            +L    + +V       L+ ++DG   K   + +  + +++   + H+  K+   A+  
Sbjct: 261 WLL-FVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRA 319

Query: 608 ISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDS 644
           + N++  ++    + Q  L    +  +LH LS   +S
Sbjct: 320 VGNIVTGDD---IQTQVILNCSALQSLLHLLSSPKES 353


>gi|6912478 karyopherin alpha 6 [Homo sapiens]
          Length = 536

 Score = 37.7 bits (86), Expect = 0.034
 Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 6/164 (3%)

Query: 35  GNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIP 94
           G N++   +I  G   RL+ LL    +  ++ +     +G++  G +   + +L+C  +P
Sbjct: 282 GPNEKIQAVIDSGVCRRLVELLMH--NDYKVASPALRAVGNIVTGDDIQTQVILNCSALP 339

Query: 95  ALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRY-TQEYI 153
            LL  L SP     +     +  I T+    +     DA + P L+ +L ++ + T++  
Sbjct: 340 CLLHLLSSPKESIRKEACWTISNI-TAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEA 398

Query: 154 CQIFSHCCKG--PDHQTILFNHGAVQNIAHLLTSLSYKVRMQAL 195
               ++   G  P+    L + G ++ +  LLT +  K+   AL
Sbjct: 399 AWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVAL 442



 Score = 33.1 bits (74), Expect = 0.84
 Identities = 43/218 (19%), Positives = 92/218 (42%), Gaps = 16/218 (7%)

Query: 432 ASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKA 491
           A+  L N+    S   + ++E+GAV +   L  S+   ++   +WAL N+A   +  +  
Sbjct: 145 AAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA--GDSSVCR 202

Query: 492 D-ILRSLSTEQLFRLLSDSD-LNVLMKTLGLLRNLLSTR---PHIDKIMSTHGKQIMQAV 546
           D +L       L  LL+ S  L +    +  L NL   +   P   K+        +  +
Sbjct: 203 DYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKV-----SPCLPVL 257

Query: 547 TLILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMF 606
           + +L    + ++       L+ ++DG   K   + +  + +++   + H+  K+   A+ 
Sbjct: 258 SRLLFSSDS-DLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALR 316

Query: 607 CISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDS 644
            + N++  ++    + Q  L    +  +LH LS   +S
Sbjct: 317 AVGNIVTGDD---IQTQVILNCSALPCLLHLLSSPKES 351


>gi|39812229 karyopherin alpha 5 [Homo sapiens]
          Length = 539

 Score = 37.0 bits (84), Expect = 0.058
 Identities = 42/186 (22%), Positives = 78/186 (41%), Gaps = 8/186 (4%)

Query: 14  LFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVL 73
           LF  DP  +      +     G N +   +I  G   RL+ LL    +  ++ +     +
Sbjct: 264 LFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMH--NDYKVVSPALRAV 321

Query: 74  GSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKF-IEACLRCLRTIFTSPVTPEELLYTD 132
           G++  G +   + +L+C  +P LL  L SP      EAC     +  T+    +     D
Sbjct: 322 GNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTV--SNITAGNRAQIQAVID 379

Query: 133 ATVIPHLMALLSRSRY-TQEYICQIFSHCCKG--PDHQTILFNHGAVQNIAHLLTSLSYK 189
           A + P L+ +L ++ + T++      ++   G  P+    L   G ++ +  LLT +  K
Sbjct: 380 ANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSK 439

Query: 190 VRMQAL 195
           +   AL
Sbjct: 440 IVQVAL 445



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 58/286 (20%), Positives = 112/286 (39%), Gaps = 55/286 (19%)

Query: 43  LIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLS 102
           +I  GAVP  + LL  E    +++ +    LG++A         +L+C I+P LL+ L +
Sbjct: 166 VIETGAVPIFIKLLNSEHE--DVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTN 223

Query: 103 ------------------------PDLKFIEACLRCL-RTIFTS-PVTPEELLYT----- 131
                                   P+   +  CL  L R +F+S P    ++ +      
Sbjct: 224 SNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLS 283

Query: 132 -----------DATVIPHLMALLSRSRY-TQEYICQIFSHCCKGPDHQT-ILFNHGAVQN 178
                      D+ V   L+ LL  + Y       +   +   G D QT ++ N  A+  
Sbjct: 284 DGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPC 343

Query: 179 IAHLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEM 238
           + HLL+S    +R +A    S +   N       +  ++D  + P + +++LQ+ +    
Sbjct: 344 LLHLLSSPKESIRKEACWTVSNITAGN----RAQIQAVIDANIFP-VLIEILQKAE-FRT 397

Query: 239 QLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERV 284
           +  +A  +T     G   T +    L  L C+  +C    +++ ++
Sbjct: 398 RKEAAWAITNATSGG---TPEQIRYLVALGCIKPLCDLLTVMDSKI 440



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 40/199 (20%), Positives = 87/199 (43%), Gaps = 14/199 (7%)

Query: 450 ILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDS 509
           ++E+GAV +   L  SE+  ++   +WAL N+A     + +  +L       L  LL++S
Sbjct: 166 VIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGD-NAECRDFVLNCEILPPLLELLTNS 224

Query: 510 D-LNVLMKTLGLLRNLLSTR---PHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCI 565
           + L      +  L NL   +   P+  K+        +  ++ +L    + +V       
Sbjct: 225 NRLTTTRNAVWALSNLCRGKNPPPNFSKV-----SPCLNVLSRLLFSS-DPDVLADVCWA 278

Query: 566 LANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDK 625
           L+ ++DG   K   + +  + +++   + H+  K+   A+  + N++  ++    + Q  
Sbjct: 279 LSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDD---IQTQVI 335

Query: 626 LRDMGIVDILHKLSQSPDS 644
           L    +  +LH LS   +S
Sbjct: 336 LNCSALPCLLHLLSSPKES 354



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 27/128 (21%), Positives = 53/128 (41%), Gaps = 8/128 (6%)

Query: 492 DILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPH--IDKIMSTHGKQIMQAVTLI 549
           +++ +   + +F   +D  L    K     R LLS  P+  ID+++   G  ++Q     
Sbjct: 82  EVVTTDMVQMIFSNNADQQLTATQK----FRKLLSKEPNPPIDQVIQKPG--VVQRFVKF 135

Query: 550 LEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCIS 609
           LE   N  ++ +    L NIA GT     ++     +      +   H  +Q  A++ + 
Sbjct: 136 LERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALG 195

Query: 610 NLIWNEEE 617
           N+  +  E
Sbjct: 196 NIAGDNAE 203


>gi|11034811 catenin (cadherin-associated protein), delta 2 (neural
           plakophilin-related arm-repeat protein) [Homo sapiens]
          Length = 1225

 Score = 36.2 bits (82), Expect = 0.099
 Identities = 27/109 (24%), Positives = 52/109 (47%), Gaps = 1/109 (0%)

Query: 462 LTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLL 521
           + Q + P+++ N    L ++ F  + KIKA+I R    + L  LL      V     G L
Sbjct: 558 MLQHQFPSVQSNAAAYLQHLCF-GDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGAL 616

Query: 522 RNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIA 570
           RNL+  + + D  ++      + A+  +L    ++E++E    +L N++
Sbjct: 617 RNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLS 665


>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
          Length = 1044

 Score = 36.2 bits (82), Expect = 0.099
 Identities = 53/225 (23%), Positives = 96/225 (42%), Gaps = 9/225 (4%)

Query: 274 CSKERLLEERVE---GAETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDI 330
           CSK    +E +    G   LA L++   E   I  +    +   A    Y +++ A   I
Sbjct: 618 CSKSHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGT--LQECASEENYRAAIKAERII 675

Query: 331 KRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAA 390
           + L  +L   +E  Q    +     A D++ R  ++     +  + + L+ +  K RLAA
Sbjct: 676 ENLVKNLNSENEQLQEHCAMAIYQCAEDKETRD-LVRLHGGLKPLASLLNNTDNKERLAA 734

Query: 391 VR-CLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEP 449
           V   +   S S + + T F+++   + L+ +L + P+E+LV     L     E   ++  
Sbjct: 735 VTGAIWKCSISKENV-TKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQE-RENRVI 792

Query: 450 ILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADIL 494
           + + G ++ L  L    N AL VN   A+   A + E  +  D L
Sbjct: 793 VRKCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRL 837


>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
          Length = 1363

 Score = 34.3 bits (77), Expect = 0.38
 Identities = 30/151 (19%), Positives = 71/151 (47%), Gaps = 1/151 (0%)

Query: 363 KKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQ 422
           K +I   N +  ++  L+ +   V +  + C+  L    +  + + ++H     L++ L 
Sbjct: 745 KDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLS 804

Query: 423 NAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMA 482
           +  D +  V+S+ +  +  +    ++ I   GA+  L  L + +  ++++ G  A+ ++A
Sbjct: 805 SDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVESLA 864

Query: 483 FQAEQKIKADILRSLSTEQLFRLLSDSDLNV 513
                  KA + +SL T+ L +LL    ++V
Sbjct: 865 SHNALIQKAFLEKSL-TKYLLKLLKAFQIDV 894


>gi|53829376 plakophilin 4 isoform b [Homo sapiens]
          Length = 1149

 Score = 33.9 bits (76), Expect = 0.49
 Identities = 27/119 (22%), Positives = 53/119 (44%), Gaps = 1/119 (0%)

Query: 462 LTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLL 521
           + Q + P+++ N    L ++ F  + K+K ++ R    + L  LL    L V     G L
Sbjct: 536 MLQHQFPSVQANAAAYLQHLCF-GDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGAL 594

Query: 522 RNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIM 580
           RNL+  +   +  ++      + A+  +L    + EV+E    +L N++     K  I+
Sbjct: 595 RNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTII 653


>gi|53829374 plakophilin 4 isoform a [Homo sapiens]
          Length = 1192

 Score = 33.9 bits (76), Expect = 0.49
 Identities = 27/119 (22%), Positives = 53/119 (44%), Gaps = 1/119 (0%)

Query: 462 LTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLL 521
           + Q + P+++ N    L ++ F  + K+K ++ R    + L  LL    L V     G L
Sbjct: 536 MLQHQFPSVQANAAAYLQHLCF-GDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGAL 594

Query: 522 RNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIM 580
           RNL+  +   +  ++      + A+  +L    + EV+E    +L N++     K  I+
Sbjct: 595 RNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTII 653


>gi|239753442 PREDICTED: HEAT repeat containing 7B1 [Homo sapiens]
          Length = 1723

 Score = 33.9 bits (76), Expect = 0.49
 Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 9/77 (11%)

Query: 420  VLQNAPDEILV--VASSMLCNLLLEFSPS----KEPILESGAVELLCGLTQSENPALRVN 473
            VL+    E+L   ++S+ +C   +EF       +E +L+  A+ L  G  Q E+ ALRV 
Sbjct: 1390 VLRGMDSEVLSCRISSTAVC---VEFMSGPVLYQEKLLKPAALLLEKGADQEEDEALRVL 1446

Query: 474  GIWALMNMAFQAEQKIK 490
             + AL NMA  A +K+K
Sbjct: 1447 SLRALGNMALGAPKKVK 1463


>gi|239748007 PREDICTED: HEAT repeat containing 7B1 [Homo sapiens]
          Length = 1706

 Score = 33.9 bits (76), Expect = 0.49
 Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 9/77 (11%)

Query: 420  VLQNAPDEILV--VASSMLCNLLLEFSPS----KEPILESGAVELLCGLTQSENPALRVN 473
            VL+    E+L   ++S+ +C   +EF       +E +L+  A+ L  G  Q E+ ALRV 
Sbjct: 1382 VLRGMDSEVLSCRISSTAVC---VEFMSGPVLYQEKLLKPAALLLEKGADQEEDEALRVL 1438

Query: 474  GIWALMNMAFQAEQKIK 490
             + AL NMA  A +K+K
Sbjct: 1439 SLRALGNMALGAPKKVK 1455


>gi|148664186 plakophilin 2 isoform 2a [Homo sapiens]
          Length = 837

 Score = 33.5 bits (75), Expect = 0.64
 Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 5/86 (5%)

Query: 18  DPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLA 77
           D Q+ + G +  +N V  +N  K  +  L  VPRLL +L+Q T   E K +   +L +L+
Sbjct: 410 DVQRAVCGAL--RNLVFEDNDNKLEVAELNGVPRLLQVLKQ-TRDLETKKQITGLLWNLS 466

Query: 78  MGTENNVKSLLDCHIIPALLQGLLSP 103
             + + +K+L+    +  L + ++ P
Sbjct: 467 --SNDKLKNLMITEALLTLTENIIIP 490


>gi|194294548 hsp70-interacting protein [Homo sapiens]
          Length = 359

 Score = 33.1 bits (74), Expect = 0.84
 Identities = 33/162 (20%), Positives = 69/162 (42%)

Query: 343 LRQAAFKLYASLGANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQ 402
           LR  A +L  +   N   I+++++    +   +     ++   VR+ A+  +  L R  +
Sbjct: 161 LRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQE 220

Query: 403 QLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGL 462
                F     +  LM+ +Q    ++ V ++ +L NLL+     K  +   G V+ L  L
Sbjct: 221 AGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLVAL 280

Query: 463 TQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFR 504
            ++E+     + + AL ++     Q ++      L  E+L R
Sbjct: 281 VRTEHSPFHEHVLGALCSLVTDFPQGVRECREPELGLEELLR 322


>gi|112363070 hsp70-interacting protein [Homo sapiens]
          Length = 359

 Score = 33.1 bits (74), Expect = 0.84
 Identities = 33/162 (20%), Positives = 69/162 (42%)

Query: 343 LRQAAFKLYASLGANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQ 402
           LR  A +L  +   N   I+++++    +   +     ++   VR+ A+  +  L R  +
Sbjct: 161 LRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQE 220

Query: 403 QLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGL 462
                F     +  LM+ +Q    ++ V ++ +L NLL+     K  +   G V+ L  L
Sbjct: 221 AGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLVAL 280

Query: 463 TQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFR 504
            ++E+     + + AL ++     Q ++      L  E+L R
Sbjct: 281 VRTEHSPFHEHVLGALCSLVTDFPQGVRECREPELGLEELLR 322


>gi|239741905 PREDICTED: HEAT repeat containing 7B1 [Homo sapiens]
          Length = 1710

 Score = 32.7 bits (73), Expect = 1.1
 Identities = 19/44 (43%), Positives = 27/44 (61%)

Query: 447  KEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIK 490
            +E +L+  A+ L  G  Q E+ ALRV  + AL NMA  A +K+K
Sbjct: 1416 QEKLLKPAALLLEKGADQEEDEALRVLSLRALGNMALGAPKKVK 1459


>gi|197333755 interferon-related developmental regulator 2 [Homo
           sapiens]
          Length = 506

 Score = 32.7 bits (73), Expect = 1.1
 Identities = 26/89 (29%), Positives = 36/89 (40%), Gaps = 31/89 (34%)

Query: 50  PRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIE 109
           P L+ +L   T+S   +  CA  LG             L C++  A +Q L+S       
Sbjct: 228 PLLVSVLSDSTASPAARLHCASALG-------------LGCYVAAADIQDLVS------- 267

Query: 110 ACLRCLRTIF----------TSPVTPEEL 128
            CL CL ++F          TSPV P  L
Sbjct: 268 -CLACLESVFSRFYGLGGSSTSPVVPASL 295


>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
           [Homo sapiens]
          Length = 607

 Score = 32.3 bits (72), Expect = 1.4
 Identities = 44/237 (18%), Positives = 102/237 (43%), Gaps = 18/237 (7%)

Query: 350 LYASLGANDEDIRKKIIETENMMDRIVTGLS-ESSVKVRLAAVRCLHSLSRSVQQLRTSF 408
           L  +L  N+ +  +KI +   ++    + L+ +SS K ++A +  +  ++++ + +R   
Sbjct: 30  LLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVANI--IAEVAKN-EFMRIPC 85

Query: 409 QDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVEL-------LCG 461
            D  +  PL+++L +   E+L+     L N+  +    +  + ++G  ++       LC 
Sbjct: 86  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 145

Query: 462 LTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLL 521
           +T   N  L       LMN +      ++A ++       L +LL     N  +  + L+
Sbjct: 146 ITDPANEKLLTVFCGMLMNYS-NENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLV 204

Query: 522 R--NLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAK 576
              NL       ++  ST+   I + +  + + +   + +E    +LA +A+    K
Sbjct: 205 AFGNLAELESSKEQFASTN---IAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIK 258



 Score = 30.4 bits (67), Expect = 5.4
 Identities = 21/63 (33%), Positives = 30/63 (47%), Gaps = 1/63 (1%)

Query: 16  DPDPQKVLQGVIDM-KNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLG 74
           DP  +K+L     M  N    N+  +A LI +G +P L+ LL     +  L   C V  G
Sbjct: 148 DPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFG 207

Query: 75  SLA 77
           +LA
Sbjct: 208 NLA 210


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.134    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,852,082
Number of Sequences: 37866
Number of extensions: 871400
Number of successful extensions: 2508
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 2426
Number of HSP's gapped (non-prelim): 103
length of query: 659
length of database: 18,247,518
effective HSP length: 109
effective length of query: 550
effective length of database: 14,120,124
effective search space: 7766068200
effective search space used: 7766068200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.