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Search of human proteins with 32313587
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32313587 cytochrome P450, family 39, subfamily A,
polypeptide 1 [Homo sapiens]
(469 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide... 959 0.0
gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1... 174 2e-43
gi|166362724 cytochrome P450, family 8, subfamily B, polypeptide... 135 8e-32
gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide... 121 2e-27
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ... 111 2e-24
gi|13699859 prostaglandin I2 (prostacyclin) synthase [Homo sapiens] 106 5e-23
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 80 3e-15
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 79 7e-15
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 79 1e-14
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 78 2e-14
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 78 2e-14
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 76 6e-14
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 73 5e-13
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid... 72 1e-12
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 72 1e-12
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 71 2e-12
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 71 2e-12
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 70 3e-12
gi|30023836 cytochrome P450 4Z1 [Homo sapiens] 70 4e-12
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 68 2e-11
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 68 2e-11
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide... 67 3e-11
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide... 67 3e-11
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide... 67 3e-11
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 65 1e-10
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 65 1e-10
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 65 2e-10
gi|4503195 cytochrome P450, family 17 [Homo sapiens] 64 4e-10
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide... 64 4e-10
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide... 62 9e-10
>gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide 1
[Homo sapiens]
Length = 469
Score = 959 bits (2479), Expect = 0.0
Identities = 469/469 (100%), Positives = 469/469 (100%)
Query: 1 MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKY 60
MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKY
Sbjct: 1 MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKY 60
Query: 61 GPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLY 120
GPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLY
Sbjct: 61 GPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLY 120
Query: 121 IMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLF 180
IMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLF
Sbjct: 121 IMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLF 180
Query: 181 STNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAK 240
STNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAK
Sbjct: 181 STNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAK 240
Query: 241 DNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIM 300
DNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIM
Sbjct: 241 DNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIM 300
Query: 301 EGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIP 360
EGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIP
Sbjct: 301 EGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIP 360
Query: 361 SGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFA 420
SGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFA
Sbjct: 361 SGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFA 420
Query: 421 LLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI 469
LLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI
Sbjct: 421 LLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI 469
>gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1
[Homo sapiens]
Length = 506
Score = 174 bits (440), Expect = 2e-43
Identities = 130/481 (27%), Positives = 235/481 (48%), Gaps = 37/481 (7%)
Query: 15 LALFLLLQR-KNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRM 73
LAL LL++R + PP IKGW+P++GV K PL F++ + ++G FTV G +
Sbjct: 31 LALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYI 90
Query: 74 TFVTEEEGINVFLKS-KKVDFELAVQNIVYRTASIPK-----NVFLALHEKLYIMLKGKM 127
TF+ + + +K+ K++ F + ++ + SI + ++ LH Y L+GK
Sbjct: 91 TFILDPFQYQLVIKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELH-LCYQFLQGKS 149
Query: 128 GTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKI 187
+ L L + QL + T +L +++ +T ++ K + N K I
Sbjct: 150 LDILLESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCDNNKFI 209
Query: 188 KEFHQYFQVYDEDFEY-GSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMT- 245
E F +D+ F Y S +P LL N ++ ++ F K AK +
Sbjct: 210 SELRDDFLKFDDKFAYLVSNIPIELLGNVKSIREKIIKCFSSE-------KLAKMQGWSE 262
Query: 246 LLQATLDIVETETSKENSP--NYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGI 303
+ Q+ D++E E+ + L LWAS++N +P FW + Y+L HP+ A+ + I
Sbjct: 263 VFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEI 322
Query: 304 SSVFGKAGKDK-----IKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPV----EI 354
+ G+ K I ++ + L++L+ ++ + E +RL + R V + + E
Sbjct: 323 DRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSET 382
Query: 355 LNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSF------LDCF-MAF 407
+Y + GDL+ + P LH +P+ F PE F+ +R+ + +K +F L C+ M F
Sbjct: 383 GDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPF 442
Query: 408 GSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLP-KQSYLHLV-GVPQPEGQCRIEY 465
G+G +CP R+FAL+E++ ++++L +D ++D P +Y L+ G+ P+ Y
Sbjct: 443 GTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFRY 502
Query: 466 K 466
K
Sbjct: 503 K 503
>gi|166362724 cytochrome P450, family 8, subfamily B, polypeptide 1
[Homo sapiens]
Length = 501
Score = 135 bits (340), Expect = 8e-32
Identities = 127/498 (25%), Positives = 216/498 (43%), Gaps = 42/498 (8%)
Query: 3 LISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGP 62
++ +++I G L L +L+++ PP KG +PW+G F K EF+++ R K+G
Sbjct: 7 VLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRMRTKHGD 66
Query: 63 IFTVFAMGNRMTFVTEEEGINVFLKS--KKVDFELAVQNIVYRTASIPKNVFLALHEKLY 120
+FTV G TFV + LK +K+DF + +V + HE ++
Sbjct: 67 VFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRS--VQGDHEMIH 124
Query: 121 IMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHG-TMDLNNLVRHLLYPVTVNMLFNK-- 177
+ L + + L + L + G ++D + L+ +LF
Sbjct: 125 SASTKHLRGDGLKDLNETMLDSLSFVM--LTSKGWSLDASCWHEDSLFRFCYYILFTAGY 182
Query: 178 -SLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLL-----RNWSKSKKWFLELFEKNIP 231
SLF K K ++ Q +++ E ++ P + R W + + LF K +
Sbjct: 183 LSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGR-LQRLFHKML- 240
Query: 232 DIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLS 291
+ + + S L + E + ++LWAS N P +FW L Y+L
Sbjct: 241 SVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLYLLK 300
Query: 292 HPDIHKAIMEGISSVFGKA---GKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKV 348
HP+ +A+ E + V G+A K L++ ++ V ET+RL+A + R V
Sbjct: 301 HPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLV 360
Query: 349 -----VKPVEILNYIIPSGDLLMLSPFW-LHRNPKYFPEPELFKPERWKKANLEKHSFLD 402
+K Y+ GD+L L P+ +H +P PEP +FK +R+ N + +D
Sbjct: 361 HEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRK--VD 418
Query: 403 CF----------MAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHL- 451
F M +GSG CP R+FAL EV++ I+L++ +D L+DP ++
Sbjct: 419 FFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQ 478
Query: 452 ---VGVPQPEGQCRIEYK 466
G QP R Y+
Sbjct: 479 RWGFGTMQPSHDVRFRYR 496
>gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide 1
[Homo sapiens]
Length = 504
Score = 121 bits (303), Expect = 2e-27
Identities = 117/497 (23%), Positives = 214/497 (43%), Gaps = 57/497 (11%)
Query: 14 CLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRM 73
CL L L ++R+ PP G IP++G +FG PLEF+ + K+G +FT MG +
Sbjct: 17 CLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYV 76
Query: 74 TFVTEEEGINVFLKS------KKVDFELAVQNIVYRTAS-IPKNVFLALHEKLYIMLKGK 126
F+T + L KK F + + +R+ + N +++ L+G
Sbjct: 77 HFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGH 136
Query: 127 MGTVNLHQFTGQLTEELHEQLENL-----------GTHGTMDLNNLVRHLLYPVTVNMLF 175
LTE + E L+ + T + + +++ +F
Sbjct: 137 A--------LNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIF 188
Query: 176 NKSLF--STNKKKIKEFHQYFQVYDEDFE-YGSQLPECLLRNWSKSKKWFLE-LFEKNIP 231
+ L T K I F+ +D+ F + LP + R +++ E L +N+
Sbjct: 189 GRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQ 248
Query: 232 DIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLS 291
++ M L + E +K + L++LWAS +N +P FW+L ++
Sbjct: 249 KRESISELISLRMFLNDTLSTFDDLEKAKTH-----LVVLWASQANTIPATFWSLFQMIR 303
Query: 292 HPDIHKAIMEGISSVFGKAGK------DKIKVSEDDLENLLLIKWCVLETIRLKAPGVIT 345
+P+ KA E + AG+ + I +S+ +L +L ++ + E++RL + +
Sbjct: 304 NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI 363
Query: 346 RKVVKP----VEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFL 401
R + +E +Y I D++ L P +H +P+ +P+P FK +R+ N + +
Sbjct: 364 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 423
Query: 402 DC--------FMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHL-- 451
C +M FGSG CP R FA+ E++ +IL+L ++ L++ K L
Sbjct: 424 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSR 483
Query: 452 --VGVPQPEGQCRIEYK 466
+G+ P +YK
Sbjct: 484 AGLGILPPLNDIEFKYK 500
>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 1 [Homo sapiens]
Length = 509
Score = 111 bits (277), Expect = 2e-24
Identities = 113/482 (23%), Positives = 210/482 (43%), Gaps = 39/482 (8%)
Query: 7 TVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTV 66
+++ ++ A L+ ++ PP I IP++G FGK+P+EF+E A KYGP+F+
Sbjct: 45 SLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSF 104
Query: 67 FAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTAS----------IPKNVFLALH 116
+G T++ + + SK D L +++ R + +P VFL
Sbjct: 105 TMVGKTFTYLLGSDAAALLFNSKNED--LNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQK 162
Query: 117 EKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFN 176
+ MLK + + Q + +E E E+ G G ++ + L+ + L
Sbjct: 163 K----MLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHG 218
Query: 177 KSLFSTNKKKIKEFHQYFQVYDEDFEYGS-----QLPECLLRNWSKSKKWFLELFEKNIP 231
K + S +K+ Q + D F + + LP R ++ + ++F K I
Sbjct: 219 KEIRSQLNEKVA---QLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQ 275
Query: 232 DIKACKSAKDNSM-TLLQATLDIVETETSKENSPNYGLL--LLWASLSNAVPVAFWTLAY 288
+ + D+ + TLL AT T E + G+L LL A + + W +
Sbjct: 276 KRRQSQEKIDDILQTLLDATYKDGRPLTDDEVA---GMLIGLLLAGQHTSSTTSAWMGFF 332
Query: 289 VLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKV 348
+ + K +V G++ ++ D L++L L+ C+ ET+RL+ P +I ++
Sbjct: 333 LARDKTLQKKCYLEQKTV---CGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRM 389
Query: 349 VK-PVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAF 407
+ P + Y IP G + +SP R + E F P+R+ + N ++ F
Sbjct: 390 ARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKF-AYVPF 448
Query: 408 GSGKFQCPARWFALLEVQMCIILILYKYDCSLLDP-LPKQSYLHLVGVPQPEGQCRIEYK 466
G+G+ +C FA ++++ +L Y+ L+D P +Y ++ P+ I YK
Sbjct: 449 GAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPE---NPVIRYK 505
Query: 467 QR 468
+R
Sbjct: 506 RR 507
>gi|13699859 prostaglandin I2 (prostacyclin) synthase [Homo sapiens]
Length = 500
Score = 106 bits (264), Expect = 5e-23
Identities = 120/504 (23%), Positives = 213/504 (42%), Gaps = 59/504 (11%)
Query: 11 ILGCLALFLLLQRKNLRRP---PCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVF 67
+L L L LLL R+ RRP P G IPW+G +FGK F+ + + K+G IFT+
Sbjct: 9 LLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTIL 68
Query: 68 AMGNRMTFVTEEEGIN--VFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLYIMLKG 125
G +T + + + V+ ++DF ++ R + + EK
Sbjct: 69 VGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEK------A 122
Query: 126 KMGTVNLHQFTGQLTEELHEQLENL----------GTHGTMDLNNLVRHLLYPVTVNMLF 175
+M LH+ LTE ++ L + G H L+ LL + +
Sbjct: 123 RMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYG 182
Query: 176 NKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWS----------KSKKWFLEL 225
++L T++ + ++ V+ + LP+ + S KS+ W
Sbjct: 183 IEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLW---- 238
Query: 226 FEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWT 285
K + + + A S L L + E S+E +L LWA+ N P AFW
Sbjct: 239 --KLLSPARLARRAH-RSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWL 295
Query: 286 LAYVLSHPDIHKAIMEGISSVFGKAGK---DKIKVSEDDLENLLLIKWCVLETIRLKAPG 342
L ++L +P+ A+ + S+ +A + + + L++ ++ + E++RL A
Sbjct: 296 LLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAP 355
Query: 343 VITRKVVKPVEI-----LNYIIPSGDLLMLSPFWL-HRNPKYFPEPELFKPERWKKAN-L 395
ITR+VV + + + + GD L+L PF R+P+ + +PE+FK R+ +
Sbjct: 356 FITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGS 415
Query: 396 EKHSFL-------DCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSY 448
EK F + M +G+G C R +A+ ++ + L+L D L++ +
Sbjct: 416 EKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPE 475
Query: 449 LHL----VGVPQPEGQCRIEYKQR 468
L G+ QPE + Y+ R
Sbjct: 476 FDLSRYGFGLMQPEHDVPVRYRIR 499
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 80.5 bits (197), Expect = 3e-15
Identities = 61/229 (26%), Positives = 107/229 (46%), Gaps = 20/229 (8%)
Query: 253 IVETETSKENSPNYGL----------LLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEG 302
+++++ SKE + L + ++A V + + + +HPD+ + + E
Sbjct: 275 MIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEE 334
Query: 303 ISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKP-VEILNYIIPS 361
I +V +K + D + + + V ET+RL + +V K VEI IP
Sbjct: 335 IDAVL----PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPK 390
Query: 362 GDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLD--CFMAFGSGKFQCPARWF 419
G ++M+ + LHR+PKY+ EPE F PER+ K N + +D + FGSG C F
Sbjct: 391 GVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN---IDPYIYTPFGSGPRNCIGMRF 447
Query: 420 ALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQR 468
AL+ +++ +I +L + L L G+ QPE ++ + R
Sbjct: 448 ALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 79.3 bits (194), Expect = 7e-15
Identities = 53/189 (28%), Positives = 100/189 (52%), Gaps = 12/189 (6%)
Query: 284 WTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRL-KAPG 342
W+L + S+P++ K + + VFGK+ + + +DL+ L ++ + ET+RL +
Sbjct: 340 WSLYLLGSNPEVQKKVDHELDDVFGKSDRP---ATVEDLKKLRYLECVIKETLRLFPSVP 396
Query: 343 VITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLE-KHSFL 401
+ R V + E+ Y + G ++ P+ LHR+P+YFP PE F+PER+ N + +H +
Sbjct: 397 LFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPY- 455
Query: 402 DCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVG--VPQPEG 459
++ F +G C + FA++E + + IL + ++ K+ L L G + +P
Sbjct: 456 -AYVPFSAGPRNCIGQKFAVMEEKTILSCILRHF---WIESNQKREELGLEGQLILRPSN 511
Query: 460 QCRIEYKQR 468
I+ K+R
Sbjct: 512 GIWIKLKRR 520
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 78.6 bits (192), Expect = 1e-14
Identities = 55/217 (25%), Positives = 101/217 (46%), Gaps = 17/217 (7%)
Query: 253 IVETETSKENSPNYGL----------LLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEG 302
+++++ SKE + L + ++A V +TL + +HPD+ + + +
Sbjct: 275 MIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKE 334
Query: 303 ISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGV-ITRKVVKPVEILNYIIPS 361
I +V +K + D + + + V ET+RL + + R K VEI IP
Sbjct: 335 IDAVL----PNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPK 390
Query: 362 GDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFAL 421
G ++++ + LH +PKY+ EPE F+PER+ K ++ + FG+G C FAL
Sbjct: 391 GSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI--YTPFGTGPRNCIGMRFAL 448
Query: 422 LEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPE 458
+ +++ +I +L + L G+ QPE
Sbjct: 449 MNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPE 485
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 77.8 bits (190), Expect = 2e-14
Identities = 92/438 (21%), Positives = 180/438 (41%), Gaps = 56/438 (12%)
Query: 36 IPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFEL 95
+P++G F K F + KY ++ ++ M +T+ + I L K + +
Sbjct: 44 LPFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLV--KECYSV 101
Query: 96 AVQNIVYRTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGT 155
+ KN ++ + ++ + FT + +L E + + +G
Sbjct: 102 FTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPT----FT---SGKLKEMVPIIAQYGD 154
Query: 156 MDLNNLVRHLLY--PVTVNMLFN----------------------KSLFSTNKKKIKEFH 191
+ + NL R PVT+ +F + F N KK+ F+
Sbjct: 155 VLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFN 214
Query: 192 QY--FQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKA--CKSAKDNSMTLL 247
F + + F + + + E L N + + + K++ IK K + + + L
Sbjct: 215 PLDPFVLSIKVFPFLTPILEAL--NITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFL 272
Query: 248 QATLDIVETETSKENSP-------NYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIM 300
Q +D ++ S+ + ++ ++A V + + + +HPD+ + +
Sbjct: 273 QLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQ 332
Query: 301 EGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKP-VEILNYII 359
+ I +V +K + D + L + V ET+RL + +V K VEI I
Sbjct: 333 KEIDTVL----PNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFI 388
Query: 360 PSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLD--CFMAFGSGKFQCPAR 417
P G ++M+ + LH +PKY+ EPE F PER+ K N + +D + FGSG C
Sbjct: 389 PKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDN---IDPYIYTPFGSGPRNCIGM 445
Query: 418 WFALLEVQMCIILILYKY 435
FAL+ +++ ++ +L +
Sbjct: 446 RFALVNMKLALVRVLQNF 463
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 77.8 bits (190), Expect = 2e-14
Identities = 82/326 (25%), Positives = 144/326 (44%), Gaps = 33/326 (10%)
Query: 132 LHQFTGQLTEELHEQLENLGTHGTMDL-----NNLVRHLLYPVTVNMLFN-KSLFSTNKK 185
+ Q L L ++ EN + D +++ L+ V ++ L N + F N K
Sbjct: 149 ISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMK 208
Query: 186 KIK--EFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNS 243
K+ +F F + F + + + E L N K + +I +K + KD
Sbjct: 209 KLLKLDFLDPFLLLISLFPFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESR-LKDKQ 265
Query: 244 MTLLQATLDIVETETSKENSPNYGL----------LLLWASL---SNAVPVAFWTLAYVL 290
+ +++++ SKE + L ++++A+ S +P + LA
Sbjct: 266 KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELA--- 322
Query: 291 SHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRL-KAPGVITRKVV 349
+HPD+ + + E I +V +K V+ D L + + V ET+RL +TR
Sbjct: 323 THPDVQQKLQEEIDAVL----PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCK 378
Query: 350 KPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGS 409
K +EI IP G +M+ + LH +PKY+ EPE F PER+ K N + L ++ FG+
Sbjct: 379 KDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSID-LYRYIPFGA 437
Query: 410 GKFQCPARWFALLEVQMCIILILYKY 435
G C FAL +++ +I L +
Sbjct: 438 GPRNCIGMRFALTNIKLAVIRALQNF 463
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 76.3 bits (186), Expect = 6e-14
Identities = 42/154 (27%), Positives = 85/154 (55%), Gaps = 5/154 (3%)
Query: 284 WTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAP-G 342
W L ++ HP+ + + + + ++ ++ DDL +L + C+ E++RL P
Sbjct: 339 WVLYHLAKHPEYQERCRQEVQELL--KDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVP 396
Query: 343 VITRKVVKPVEILN-YIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFL 401
VI+R V + + + + +IP G + ++S F H NP +P+PE++ P R+ N+++ S L
Sbjct: 397 VISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPL 456
Query: 402 DCFMAFGSGKFQCPARWFALLEVQMCIILILYKY 435
F+ F +G C + FA+ E+++ + L L ++
Sbjct: 457 -AFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF 489
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 73.2 bits (178), Expect = 5e-13
Identities = 82/327 (25%), Positives = 144/327 (44%), Gaps = 34/327 (10%)
Query: 132 LHQFTGQLTEELHEQLENLGTHGTMDL-----NNLVRHLLYPVTVNMLFN-KSLFSTNKK 185
+ Q L L ++ EN + D +++ L+ V ++ L N + F N K
Sbjct: 149 ISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMK 208
Query: 186 KIK--EFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNS 243
K+ +F F + F + + + E L N K + +I +K + KD
Sbjct: 209 KLLKLDFLDPFLLLISLFPFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESR-LKDKQ 265
Query: 244 MTLLQATLDIVETETSKENSPNYGL----------LLLWASL---SNAVPVAFWTLAYVL 290
+ +++++ SKE + L ++++A+ S +P + LA
Sbjct: 266 KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELA--- 322
Query: 291 SHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRL-KAPGVITRKVV 349
+HPD+ + + E I +V +K V+ D L + + V ET+RL +TR
Sbjct: 323 THPDVQQKLQEEIDAVL----PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCK 378
Query: 350 KPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPE-RWKKANLEKHSFLDCFMAFG 408
K +EI IP G +M+ + LH +PKY+ EPE F PE R+ K N + L ++ FG
Sbjct: 379 KDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSID-LYRYIPFG 437
Query: 409 SGKFQCPARWFALLEVQMCIILILYKY 435
+G C FAL +++ +I L +
Sbjct: 438 AGPRNCIGMRFALTNIKLAVIRALQNF 464
>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 2 [Homo sapiens]
Length = 404
Score = 71.6 bits (174), Expect = 1e-12
Identities = 92/420 (21%), Positives = 174/420 (41%), Gaps = 39/420 (9%)
Query: 69 MGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTAS----------IPKNVFLALHEK 118
+G T++ + + SK D L +++ R + +P VFL +
Sbjct: 2 VGKTFTYLLGSDAAALLFNSKNED--LNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK- 58
Query: 119 LYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKS 178
MLK + + Q + +E E E+ G G ++ + L+ + L K
Sbjct: 59 ---MLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKE 115
Query: 179 LFSTNKKKIKEFHQYFQVYDEDFEYGSQL-----PECLLRNWSKSKKWFLELFEKNIPDI 233
+ S +K+ Q + D F + + L P R ++ + ++F K I
Sbjct: 116 IRSQLNEKVA---QLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKR 172
Query: 234 KACKSAKDNSM-TLLQATLDIVETETSKENSPNYGLL--LLWASLSNAVPVAFWTLAYVL 290
+ + D+ + TLL AT T E + G+L LL A + + W ++
Sbjct: 173 RQSQEKIDDILQTLLDATYKDGRPLTDDEVA---GMLIGLLLAGQHTSSTTSAWMGFFLA 229
Query: 291 SHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVK 350
+ K +V G++ ++ D L++L L+ C+ ET+RL+ P +I ++ +
Sbjct: 230 RDKTLQKKCYLEQKTV---CGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMAR 286
Query: 351 -PVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGS 409
P + Y IP G + +SP R + E F P+R+ + N ++ FG+
Sbjct: 287 TPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKF-AYVPFGA 345
Query: 410 GKFQCPARWFALLEVQMCIILILYKYDCSLLDP-LPKQSYLHLVGVPQPEGQCRIEYKQR 468
G+ +C FA ++++ +L Y+ L+D P +Y ++ P+ I YK+R
Sbjct: 346 GRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPE---NPVIRYKRR 402
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 71.6 bits (174), Expect = 1e-12
Identities = 53/169 (31%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 270 LLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIK 329
LL A + W L + HP++ A+ I++ S L L L+K
Sbjct: 314 LLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSS--AYPSATVLSQLPLLK 371
Query: 330 WCVLETIRLK--APGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKP 387
V E +RL PG +R K + + +YIIP L+ L + R+P FPEP F+P
Sbjct: 372 AVVKEVLRLYPVVPGN-SRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRP 430
Query: 388 ERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYD 436
RW H F + FG GK C R A LE+QM + IL ++
Sbjct: 431 ARWLGEGPTPHPFAS--LPFGFGKRSCMGRRLAELELQMALAQILTHFE 477
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 70.9 bits (172), Expect = 2e-12
Identities = 38/154 (24%), Positives = 80/154 (51%), Gaps = 5/154 (3%)
Query: 284 WTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGV 343
W L ++ HP+ + + + + ++ I++ DDL L + C+ E++RL P
Sbjct: 339 WVLYHLAKHPEYQEQCRQEVQELL--KDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVP 396
Query: 344 ITRKVVKPVEIL--NYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFL 401
+ + +L +IP G + +++ +H NP +P+PE++ P R+ + N+++ S L
Sbjct: 397 VISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPL 456
Query: 402 DCFMAFGSGKFQCPARWFALLEVQMCIILILYKY 435
F+ F +G C + FA+ E+++ + L L +
Sbjct: 457 -AFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHF 489
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 70.9 bits (172), Expect = 2e-12
Identities = 38/154 (24%), Positives = 80/154 (51%), Gaps = 5/154 (3%)
Query: 284 WTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGV 343
W L ++ HP+ + + + + ++ I++ DDL L + C+ E++RL P
Sbjct: 339 WVLYHLAKHPEYQEQCRQEVQELL--KDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVP 396
Query: 344 ITRKVVKPVEIL--NYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFL 401
+ + +L +IP G + +++ +H NP +P+PE++ P R+ + N+++ S L
Sbjct: 397 VISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPL 456
Query: 402 DCFMAFGSGKFQCPARWFALLEVQMCIILILYKY 435
F+ F +G C + FA+ E+++ + L L +
Sbjct: 457 -AFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHF 489
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 70.5 bits (171), Expect = 3e-12
Identities = 41/157 (26%), Positives = 80/157 (50%), Gaps = 11/157 (7%)
Query: 284 WTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAP-- 341
W L ++ HP+ + + + + ++ ++ DDL L + C+ E++RL P
Sbjct: 339 WVLYHLAKHPEYQERCRQEVQELL--KDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVP 396
Query: 342 ---GVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKH 398
T+ +V P +IP G + ++S F H NP +P+PE++ P R+ N+++
Sbjct: 397 AVSRCCTQDIVLPD---GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKER 453
Query: 399 SFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKY 435
S L F+ F +G C + FA+ E+++ + L L ++
Sbjct: 454 SPL-AFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRF 489
>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
Length = 505
Score = 70.1 bits (170), Expect = 4e-12
Identities = 80/337 (23%), Positives = 149/337 (44%), Gaps = 42/337 (12%)
Query: 107 IPKNVFLALHEKLYIM-LKGKMGTVNLHQFTGQLTEELHEQLE---NLGTHGTMDLNNLV 162
I +N L L + + +M L M HQ + QL L L+ NL +NN +
Sbjct: 171 IAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFL 230
Query: 163 RHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKW- 221
H + +FS K +E HQ+ + +D + L + L ++ ++ ++W
Sbjct: 231 HH--NDLVFKFSSQGQIFS---KFNQELHQFTEKVIQDRK--ESLKDKLKQDTTQKRRWD 283
Query: 222 FLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPV 281
FL++ ++ KD S LQA E +T ++A
Sbjct: 284 FLDILLS-----AKSENTKDFSEADLQA-----EVKT-----------FMFAGHDTTSSA 322
Query: 282 AFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAP 341
W L + +P+ + + I + G D ++ + L + C+ E +RL AP
Sbjct: 323 ISWILYCLAKYPEHQQRCRDEIRELLG----DGSSITWEHLSQMPYTTMCIKECLRLYAP 378
Query: 342 GV-ITRKVVKPVEILN-YIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEK-H 398
V I+R + KP+ + +P+G + ++ + LH NP ++ +P++F P R+ + N EK H
Sbjct: 379 VVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIH 438
Query: 399 SFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKY 435
+ F+ F +G C + FA++E ++ + L L ++
Sbjct: 439 PY--AFIPFSAGLRNCIGQHFAIIECKVAVALTLLRF 473
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 68.2 bits (165), Expect = 2e-11
Identities = 55/198 (27%), Positives = 92/198 (46%), Gaps = 11/198 (5%)
Query: 273 ASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCV 332
A++ W L + +P + + +++ I SV + + +DL N+ +K C+
Sbjct: 326 AAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA----EDLRNMPYLKACL 381
Query: 333 LETIRLKAPGV--ITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERW 390
E++RL P V TR + K + Y +P G +LML+ L + F + F+PERW
Sbjct: 382 KESMRL-TPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERW 440
Query: 391 KKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLH 450
+ + + F + FG GK C R A L++ + + I+ KYD D P + LH
Sbjct: 441 LQEKEKINPF--AHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVE-MLH 497
Query: 451 LVGVPQPEGQCRIEYKQR 468
G P + I + QR
Sbjct: 498 -SGTLVPSRELPIAFCQR 514
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 68.2 bits (165), Expect = 2e-11
Identities = 41/157 (26%), Positives = 80/157 (50%), Gaps = 11/157 (7%)
Query: 284 WTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAP-- 341
W L + HP+ + + + + ++ ++ DDL L + C+ E++RL P
Sbjct: 339 WVLYNLARHPEYQERCRQEVQELL--KDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIP 396
Query: 342 ---GVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKH 398
T+ VV P + +IP G++ ++ F +H NP +P+PE++ P R+ N +K
Sbjct: 397 TFARGCTQDVVLPD---SRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKR 453
Query: 399 SFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKY 435
S + F+ F +G C + FA+ E+++ + L L ++
Sbjct: 454 SPM-AFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRF 489
>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform a [Homo sapiens]
Length = 512
Score = 67.4 bits (163), Expect = 3e-11
Identities = 47/162 (29%), Positives = 81/162 (50%), Gaps = 10/162 (6%)
Query: 284 WTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAP-G 342
W L + +P+ E + + G D+ DDL + + C+ E+ RL P
Sbjct: 327 WFLYCMALYPEHQHRCREEVREILG----DQDFFQWDDLGKMTYLTMCIKESFRLYPPVP 382
Query: 343 VITRKVVKPVEILN-YIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEK-HSF 400
+ R++ KPV ++ +P+G L+ + + LHRN +P+PE+F R+ N K H F
Sbjct: 383 QVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPF 442
Query: 401 LDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDP 442
FM F +G C + FA+ E+++ + L +++ S LDP
Sbjct: 443 --AFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-LDP 481
>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform b [Homo sapiens]
Length = 511
Score = 67.4 bits (163), Expect = 3e-11
Identities = 47/162 (29%), Positives = 81/162 (50%), Gaps = 10/162 (6%)
Query: 284 WTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAP-G 342
W L + +P+ E + + G D+ DDL + + C+ E+ RL P
Sbjct: 326 WFLYCMALYPEHQHRCREEVREILG----DQDFFQWDDLGKMTYLTMCIKESFRLYPPVP 381
Query: 343 VITRKVVKPVEILN-YIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEK-HSF 400
+ R++ KPV ++ +P+G L+ + + LHRN +P+PE+F R+ N K H F
Sbjct: 382 QVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPF 441
Query: 401 LDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDP 442
FM F +G C + FA+ E+++ + L +++ S LDP
Sbjct: 442 --AFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-LDP 480
>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
[Homo sapiens]
Length = 519
Score = 67.4 bits (163), Expect = 3e-11
Identities = 48/161 (29%), Positives = 81/161 (50%), Gaps = 10/161 (6%)
Query: 284 WTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGV 343
W L + +HP + E I S+ G D ++ + L+ + C+ E +RL P
Sbjct: 332 WILYALATHPKHQERCREEIHSLLG----DGASITWNHLDQMPYTTMCIKEALRLYPPVP 387
Query: 344 -ITRKVVKPVEILN-YIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFL 401
I R++ PV + +P G +++LS + LH NPK +P PE+F P R+ + + HS
Sbjct: 388 GIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ-HS-- 444
Query: 402 DCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDP 442
F+ F G C + FA+ E+++ L L +++ L DP
Sbjct: 445 HAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL-LPDP 484
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 65.5 bits (158), Expect = 1e-10
Identities = 43/162 (26%), Positives = 84/162 (51%), Gaps = 8/162 (4%)
Query: 275 LSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLE 334
++N + A + LA ++PD + ++ + K + E+ L L ++ + E
Sbjct: 347 ITNTLSFATYLLA---TNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMV---IAE 400
Query: 335 TIRLKAPGV-ITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKA 393
T+R+ P TR+ + E+L IP+G +L ++ LH +P+++P PE F PER+
Sbjct: 401 TLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAE 460
Query: 394 NLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKY 435
++H ++ FG+G C LLEV++ ++ +L+K+
Sbjct: 461 ARQQHRPF-TYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKF 501
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 65.5 bits (158), Expect = 1e-10
Identities = 43/162 (26%), Positives = 84/162 (51%), Gaps = 8/162 (4%)
Query: 275 LSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLE 334
++N + A + LA ++PD + ++ + K + E+ L L ++ + E
Sbjct: 347 ITNTLSFATYLLA---TNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMV---IAE 400
Query: 335 TIRLKAPGV-ITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKA 393
T+R+ P TR+ + E+L IP+G +L ++ LH +P+++P PE F PER+
Sbjct: 401 TLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAE 460
Query: 394 NLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKY 435
++H ++ FG+G C LLEV++ ++ +L+K+
Sbjct: 461 ARQQHRPF-TYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKF 501
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 64.7 bits (156), Expect = 2e-10
Identities = 39/154 (25%), Positives = 73/154 (47%), Gaps = 5/154 (3%)
Query: 284 WTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGV 343
W L + HP+ + + + + +D ++ DDL L + CV E++RL P
Sbjct: 339 WVLYNLARHPEYQERCRQEVQELL--KDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAP 396
Query: 344 ITRKVVKPVEIL--NYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFL 401
+ +L +IP G ++ +H NP +P+PE++ P R+ N + S L
Sbjct: 397 FISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPL 456
Query: 402 DCFMAFGSGKFQCPARWFALLEVQMCIILILYKY 435
F+ F +G C + FA+ E+++ + L+L +
Sbjct: 457 -AFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHF 489
>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
Length = 508
Score = 63.5 bits (153), Expect = 4e-10
Identities = 46/172 (26%), Positives = 81/172 (47%), Gaps = 7/172 (4%)
Query: 273 ASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCV 332
A + V WTLA++L +P + K + E I G + I D LLL++ +
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTIS----DRNRLLLLEATI 357
Query: 333 LETIRLK--APGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERW 390
E +RL+ AP +I K I + + G ++++ + LH N K + +P+ F PER+
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
Query: 391 -KKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLD 441
A + S ++ FG+G C A E+ + + +L ++D + D
Sbjct: 418 LNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPD 469
>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
[Homo sapiens]
Length = 531
Score = 63.5 bits (153), Expect = 4e-10
Identities = 39/158 (24%), Positives = 83/158 (52%), Gaps = 5/158 (3%)
Query: 284 WTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAP-G 342
W L + +P+ + E I V G++ ++ DDL L C+ E++R P
Sbjct: 346 WMLFNLAKYPEYQEKCREEIQEVM--KGRELEELEWDDLTQLPFTTMCIKESLRQYPPVT 403
Query: 343 VITRKVVKPVEILN-YIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFL 401
+++R+ + +++ + IIP G + ++S + H NP +P+ +++ P R+ N ++ S L
Sbjct: 404 LVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPL 463
Query: 402 DCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSL 439
++ F +G C + FA+ E+++ + L L ++ S+
Sbjct: 464 -AYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSV 500
>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 503
Score = 62.4 bits (150), Expect = 9e-10
Identities = 82/345 (23%), Positives = 148/345 (42%), Gaps = 43/345 (12%)
Query: 96 AVQNIVYRTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQL---ENLGT 152
AVQ + ++ ++ AL +K+ +G + T+++ T E E LG
Sbjct: 153 AVQRFLPMVDAVARDFSQALKKKVLQNARGSL-TLDVQPSIFHYTIEASNLALFGERLGL 211
Query: 153 HG----TMDLNNL-VRHLLYPVTVNMLFN-KSLFSTNKKKIKEFHQYFQVYDEDFEYGSQ 206
G + LN L +++ TV ++F +SL K+ + ++F+ +D F+YG
Sbjct: 212 VGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKV--WKEHFEAWDCIFQYGDN 269
Query: 207 LPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNY 266
C+ +K + EL ++ T + A L ++ E S +
Sbjct: 270 ---CI-------QKIYQEL-----------AFSRPQQYTSIVAEL-LLNAELSPDAIKAN 307
Query: 267 GLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLL 326
+ L S+ V TL + +P++ +A+ + + + K + + L
Sbjct: 308 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTE----LP 363
Query: 327 LIKWCVLETIRLKAPGVITRKVVKPVEIL-NYIIPSGDLLMLSPFWLHRNPKYFPEPELF 385
L++ + ET+RL G+ +V +L NY IP+G L+ + + L RNP FP PE +
Sbjct: 364 LLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423
Query: 386 KPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIIL 430
P+RW +F + FG G QC R L E +M ++L
Sbjct: 424 NPQRWLDIRGSGRNFY--HVPFGFGMRQCLGR--RLAEAEMLLLL 464
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,070,561
Number of Sequences: 37866
Number of extensions: 807750
Number of successful extensions: 1854
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 1720
Number of HSP's gapped (non-prelim): 99
length of query: 469
length of database: 18,247,518
effective HSP length: 106
effective length of query: 363
effective length of database: 14,233,722
effective search space: 5166841086
effective search space used: 5166841086
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.