BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo sapiens] (464 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 946 0.0 gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 929 0.0 gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 929 0.0 gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 497 e-141 gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 487 e-138 gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 487 e-138 gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 487 e-138 gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 434 e-122 gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 434 e-122 gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 275 6e-74 gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 275 8e-74 gi|4502023 AKT2 kinase [Homo sapiens] 268 1e-71 gi|62241015 AKT1 kinase [Homo sapiens] 255 7e-68 gi|62241013 AKT1 kinase [Homo sapiens] 255 7e-68 gi|62241011 AKT1 kinase [Homo sapiens] 255 7e-68 gi|133908623 protein kinase C, iota [Homo sapiens] 249 4e-66 gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 244 9e-65 gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 243 3e-64 gi|4885563 protein kinase C, epsilon [Homo sapiens] 240 2e-63 gi|28557781 protein kinase C, eta [Homo sapiens] 233 4e-61 gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 233 4e-61 gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 233 4e-61 gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 233 4e-61 gi|4506067 protein kinase C, alpha [Homo sapiens] 231 1e-60 gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 221 1e-57 gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 221 1e-57 gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 218 9e-57 gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 218 1e-56 gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 217 2e-56 gi|5453974 protein kinase N2 [Homo sapiens] 214 1e-55 >gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo sapiens] Length = 464 Score = 946 bits (2444), Expect = 0.0 Identities = 464/464 (100%), Positives = 464/464 (100%) Query: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT Sbjct: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60 Query: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD Sbjct: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120 Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180 Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240 Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300 Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPEPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL 360 VLTDFGLCKEGIAISDTTTTFCGTPEPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPEPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL 360 Query: 361 EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTA 420 EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTA Sbjct: 361 EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTA 420 Query: 421 FTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL 464 FTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL Sbjct: 421 FTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL 464 >gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo sapiens] Length = 496 Score = 929 bits (2401), Expect = 0.0 Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%) Query: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT Sbjct: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60 Query: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD Sbjct: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120 Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180 Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240 Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300 Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPE--------------------------------PP 328 VLTDFGLCKEGIAISDTTTTFCGTPE PP Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP 360 Query: 329 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 388 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE Sbjct: 361 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420 Query: 389 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 448 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD Sbjct: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 480 Query: 449 AFVGFSYAPPSEDLFL 464 AFVGFSYAPPSEDLFL Sbjct: 481 AFVGFSYAPPSEDLFL 496 >gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo sapiens] Length = 496 Score = 929 bits (2401), Expect = 0.0 Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%) Query: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT Sbjct: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60 Query: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD Sbjct: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120 Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180 Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240 Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300 Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPE--------------------------------PP 328 VLTDFGLCKEGIAISDTTTTFCGTPE PP Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP 360 Query: 329 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 388 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE Sbjct: 361 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420 Query: 389 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 448 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD Sbjct: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 480 Query: 449 AFVGFSYAPPSEDLFL 464 AFVGFSYAPPSEDLFL Sbjct: 481 AFVGFSYAPPSEDLFL 496 >gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [Homo sapiens] Length = 526 Score = 497 bits (1280), Expect = e-141 Identities = 256/430 (59%), Positives = 308/430 (71%), Gaps = 45/430 (10%) Query: 67 AMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH-- 124 A L P R F N DP F+KQRR GLN+FIQ + HP+V++ L++ P+ Sbjct: 103 ANILTKPDPRTFWTNDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPE 162 Query: 125 --QSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRK 182 ++PS S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K Sbjct: 163 LMNANPSPPP---------SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 213 Query: 183 LDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDF 242 + FYAVKVLQKK +L +KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD+ Sbjct: 214 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 273 Query: 243 VNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVL 302 +NGGELF+HLQRER F E RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VL Sbjct: 274 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVL 333 Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330 TDFGLCKE I + TT+TFCGTPE PPFY Sbjct: 334 TDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY 393 Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESL 390 R+ AEMYDNIL+KPL L+P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF + Sbjct: 394 SRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLI 453 Query: 391 SWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAF 450 +W DL+ KKI PPFNPNV+GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF Sbjct: 454 NWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAF 513 Query: 451 VGFSYAPPSE 460 +GFSYAPP++ Sbjct: 514 LGFSYAPPTD 523 >gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo sapiens] Length = 431 Score = 487 bits (1254), Expect = e-138 Identities = 248/411 (60%), Positives = 300/411 (72%), Gaps = 45/411 (10%) Query: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141 F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS Sbjct: 27 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 77 Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201 S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L + Sbjct: 78 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 137 Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261 KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E Sbjct: 138 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 197 Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321 RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF Sbjct: 198 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 257 Query: 322 CGTPE--------------------------------PPFYCRDVAEMYDNILHKPLSLR 349 CGTPE PPFY R+ AEMYDNIL+KPL L+ Sbjct: 258 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 317 Query: 350 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 409 P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+ Sbjct: 318 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 377 Query: 410 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 460 GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++ Sbjct: 378 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 428 >gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [Homo sapiens] Length = 445 Score = 487 bits (1254), Expect = e-138 Identities = 248/411 (60%), Positives = 300/411 (72%), Gaps = 45/411 (10%) Query: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141 F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS Sbjct: 41 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 91 Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201 S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L + Sbjct: 92 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 151 Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261 KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E Sbjct: 152 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 211 Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321 RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF Sbjct: 212 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 271 Query: 322 CGTPE--------------------------------PPFYCRDVAEMYDNILHKPLSLR 349 CGTPE PPFY R+ AEMYDNIL+KPL L+ Sbjct: 272 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 331 Query: 350 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 409 P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+ Sbjct: 332 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 391 Query: 410 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 460 GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++ Sbjct: 392 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 442 >gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [Homo sapiens] Length = 459 Score = 487 bits (1254), Expect = e-138 Identities = 248/411 (60%), Positives = 300/411 (72%), Gaps = 45/411 (10%) Query: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141 F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS Sbjct: 55 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 105 Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201 S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L + Sbjct: 106 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 165 Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261 KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E Sbjct: 166 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 225 Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321 RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF Sbjct: 226 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 285 Query: 322 CGTPE--------------------------------PPFYCRDVAEMYDNILHKPLSLR 349 CGTPE PPFY R+ AEMYDNIL+KPL L+ Sbjct: 286 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 345 Query: 350 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 409 P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+ Sbjct: 346 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 405 Query: 410 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 460 GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++ Sbjct: 406 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 456 >gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha [Homo sapiens] Length = 367 Score = 434 bits (1117), Expect = e-122 Identities = 217/349 (62%), Positives = 259/349 (74%), Gaps = 35/349 (10%) Query: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205 NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ Sbjct: 19 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 78 Query: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265 HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF Sbjct: 79 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 138 Query: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325 YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP Sbjct: 139 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 198 Query: 326 E--------------------------------PPFYCRDVAEMYDNILHKPLSLRPGVS 353 E PPFY +DV++MY+NILH+PL + G + Sbjct: 199 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 258 Query: 354 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 413 + A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D Sbjct: 259 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 318 Query: 414 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 462 +++FD FT+E V S+ + D AS A AF+GFSYAP +D+ Sbjct: 319 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 364 >gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta [Homo sapiens] Length = 427 Score = 434 bits (1117), Expect = e-122 Identities = 217/349 (62%), Positives = 259/349 (74%), Gaps = 35/349 (10%) Query: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205 NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ Sbjct: 79 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 138 Query: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265 HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF Sbjct: 139 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 198 Query: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325 YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP Sbjct: 199 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 258 Query: 326 E--------------------------------PPFYCRDVAEMYDNILHKPLSLRPGVS 353 E PPFY +DV++MY+NILH+PL + G + Sbjct: 259 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 318 Query: 354 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 413 + A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D Sbjct: 319 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 378 Query: 414 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 462 +++FD FT+E V S+ + D AS A AF+GFSYAP +D+ Sbjct: 379 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 424 >gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] Length = 465 Score = 275 bits (703), Expect = 6e-74 Identities = 162/401 (40%), Positives = 219/401 (54%), Gaps = 58/401 (14%) Query: 87 IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137 +K R N FI +++ + + +D+P+ + + +E E Sbjct: 62 MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116 Query: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190 TSQ N+G S H + T DFD+LK++GKG+FGKV+L + K GK+YA+ Sbjct: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176 Query: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250 K+L+K++++ + E H + E VL KN +HPFL L YSFQT ++L FV+++VNGGELFF Sbjct: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235 Query: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310 HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD GH+ +TDFGLCKE Sbjct: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295 Query: 311 GIAISDTTTTFCGTPE--------------------------------PPFYCRDVAEMY 338 GI + T TFCGTPE PFY +D +++ Sbjct: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355 Query: 339 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 397 + IL + + +S A S+L LL KD RL G +D EI H FF ++W D+ Sbjct: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415 Query: 398 KKIPPPFNPNVAGPDDIRNFDTAFTEETV---PYSVCVSSD 435 KK+ PPF P V D R FD FT +T+ P C SD Sbjct: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456 >gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] Length = 479 Score = 275 bits (702), Expect = 8e-74 Identities = 164/419 (39%), Positives = 225/419 (53%), Gaps = 55/419 (13%) Query: 87 IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137 +K R N FI +++ + + +D+P+ + + +E E Sbjct: 62 MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116 Query: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190 TSQ N+G S H + T DFD+LK++GKG+FGKV+L + K GK+YA+ Sbjct: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176 Query: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250 K+L+K++++ + E H + E VL KN +HPFL L YSFQT ++L FV+++VNGGELFF Sbjct: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235 Query: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310 HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD GH+ +TDFGLCKE Sbjct: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295 Query: 311 GIAISDTTTTFCGTPE--------------------------------PPFYCRDVAEMY 338 GI + T TFCGTPE PFY +D +++ Sbjct: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355 Query: 339 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 397 + IL + + +S A S+L LL KD RL G +D EI H FF ++W D+ Sbjct: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415 Query: 398 KKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYA 456 KK+ PPF P V D R FD FT +T+ + D ++ E F FSY+ Sbjct: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYS 474 >gi|4502023 AKT2 kinase [Homo sapiens] Length = 481 Score = 268 bits (684), Expect = 1e-71 Identities = 155/381 (40%), Positives = 219/381 (57%), Gaps = 41/381 (10%) Query: 113 VRAFLQMDSPKHQSDPSED--EDERSSQKLHSTSQNINLGPSGNPHAKPT--DFDFLKVI 168 +RA + + Q P ED + + S ST++ + + S AK T DFD+LK++ Sbjct: 100 MRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVS-KARAKVTMNDFDYLKLL 158 Query: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228 GKG+FGKV+L + K G++YA+K+L+K++++ + E H + E VL +N +HPFL L Y Sbjct: 159 GKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKY 217 Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288 +FQT ++L FV+++ NGGELFFHL RER F E RARFY AEI SAL YLHS +VYRD+K Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277 Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE---------------------- 326 EN++LD GH+ +TDFGLCKEGI+ T TFCGTPE Sbjct: 278 LENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG 337 Query: 327 ----------PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAK 375 PFY +D +++ IL + + +S A S+L LL+KD + RL G Sbjct: 338 VVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGP 397 Query: 376 EDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSD 435 D E+ H FF S++W D+VQKK+ PPF P V D R FD FT +++ ++ Sbjct: 398 SDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI--TITPPDR 455 Query: 436 YSIVNASVLEADDAFVGFSYA 456 Y + L+ F FSY+ Sbjct: 456 YDSLGLLELDQRTHFPQFSYS 476 >gi|62241015 AKT1 kinase [Homo sapiens] Length = 480 Score = 255 bits (651), Expect = 7e-68 Identities = 143/337 (42%), Positives = 193/337 (57%), Gaps = 41/337 (12%) Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183 + E+E + S S N AKP +F++LK++GKG+FGKV+L K K Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171 Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243 G++YA+K+L+K++++ + E H + E VL +N +HPFL L YSFQT ++L FV+++ Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230 Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302 NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD GH+ + Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290 Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330 TDFGLCKEGI T TFCGTPE PFY Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350 Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 389 +D ++++ IL + + + A S+L LL+KD + RL G ED EI H FF Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 Query: 390 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 426 + W + +KK+ PPF P V D R FD FT + + Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447 >gi|62241013 AKT1 kinase [Homo sapiens] Length = 480 Score = 255 bits (651), Expect = 7e-68 Identities = 143/337 (42%), Positives = 193/337 (57%), Gaps = 41/337 (12%) Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183 + E+E + S S N AKP +F++LK++GKG+FGKV+L K K Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171 Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243 G++YA+K+L+K++++ + E H + E VL +N +HPFL L YSFQT ++L FV+++ Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230 Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302 NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD GH+ + Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290 Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330 TDFGLCKEGI T TFCGTPE PFY Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350 Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 389 +D ++++ IL + + + A S+L LL+KD + RL G ED EI H FF Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 Query: 390 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 426 + W + +KK+ PPF P V D R FD FT + + Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447 >gi|62241011 AKT1 kinase [Homo sapiens] Length = 480 Score = 255 bits (651), Expect = 7e-68 Identities = 143/337 (42%), Positives = 193/337 (57%), Gaps = 41/337 (12%) Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183 + E+E + S S N AKP +F++LK++GKG+FGKV+L K K Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171 Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243 G++YA+K+L+K++++ + E H + E VL +N +HPFL L YSFQT ++L FV+++ Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230 Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302 NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD GH+ + Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290 Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330 TDFGLCKEGI T TFCGTPE PFY Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350 Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 389 +D ++++ IL + + + A S+L LL+KD + RL G ED EI H FF Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 Query: 390 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 426 + W + +KK+ PPF P V D R FD FT + + Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447 >gi|133908623 protein kinase C, iota [Homo sapiens] Length = 596 Score = 249 bits (636), Expect = 4e-66 Identities = 148/396 (37%), Positives = 209/396 (52%), Gaps = 63/396 (15%) Query: 117 LQMDSPKHQSD------PSEDEDERSSQKLHSTSQNINLGPSGNPHAKP--TDFDFLKVI 168 + MD SD P S ++ + +N SG + DFD L+VI Sbjct: 201 MPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260 Query: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228 G+GS+ KVLL + K + YA+KV++K++V + ++ + E++V + HPFLVGLH Sbjct: 261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS 320 Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288 FQT +L+FV+++VNGG+L FH+QR+R PE ARFY+AEI+ AL YLH I+YRDLK Sbjct: 321 CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 380 Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP----------------------- 325 +N+LLDS GH+ LTD+G+CKEG+ DTT+TFCGTP Sbjct: 381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 440 Query: 326 ---------EPPFYCRDVAEMYDN------------ILHKPLSLRPGVSLTAWSILEELL 364 PF D+ DN IL K + + +S+ A S+L+ L Sbjct: 441 VLMFEMMAGRSPF---DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 497 Query: 365 EKDRQNRLGA--KEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFT 422 KD + RLG + F +IQ HPFF ++ W + QK++ PPF PN++G + NFD+ FT Sbjct: 498 NKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFT 557 Query: 423 EETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458 E V + D IV F GF Y P Sbjct: 558 NEPVQLT---PDDDDIVRKI---DQSEFEGFEYINP 587 >gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo sapiens] Length = 482 Score = 244 bits (624), Expect = 9e-65 Identities = 147/360 (40%), Positives = 207/360 (57%), Gaps = 50/360 (13%) Query: 138 QKLHSTSQNINLGPSG-NPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVL 193 +++ T ++N+GP PH F+ L+V+GKG +GKV ++ GK YA+KVL Sbjct: 46 EEVELTETSVNVGPERIGPHC----FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVL 101 Query: 194 QK-KIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHL 252 +K KIV N K+ H AERN+L ++VKHPF+V L Y+FQT KLY +L+ ++GGELF HL Sbjct: 102 RKAKIVRNAKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHL 160 Query: 253 QRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGI 312 +RE F E A FY AEI ALG+LHS I+YRDLKPENI+L S GH+ LTDFGLCKE I Sbjct: 161 EREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI 220 Query: 313 AISDTTTTFCGTPE--------------------------------PPFYCRDVAEMYDN 340 T TFCGT E PPF + + D Sbjct: 221 HEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDK 280 Query: 341 ILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQKK 399 I+ L+L P ++ A ++++ L+++ R+ G D ++Q HPFF ++W DL+ + Sbjct: 281 IIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWR 340 Query: 400 IPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 459 + PPF P + +D+ FDT FT +T P S D + ++ S A+ AF+GF+Y PS Sbjct: 341 VDPPFRPCLQSEEDVSQFDTRFTRQT-PVD---SPDDTALSES---ANQAFLGFTYVAPS 393 >gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo sapiens] Length = 525 Score = 243 bits (619), Expect = 3e-64 Identities = 147/359 (40%), Positives = 206/359 (57%), Gaps = 48/359 (13%) Query: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVLQ 194 +K + ++N GP +P F+ L+V+GKG +GKV ++ GK +A+KVL+ Sbjct: 70 EKFEISETSVNRGPE---KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK 126 Query: 195 KK-IVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ 253 K IV N K+ H AERN+L + VKHPF+V L Y+FQT KLY +L++++GGELF L+ Sbjct: 127 KAMIVRNAKDTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLE 185 Query: 254 RERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIA 313 RE F E A FY AEI+ ALG+LH I+YRDLKPENI+L+ GHV LTDFGLCKE I Sbjct: 186 REGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIH 245 Query: 314 ISDTTTTFCGTPE--------------------------------PPFYCRDVAEMYDNI 341 T TFCGT E PPF + + D I Sbjct: 246 DGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKI 305 Query: 342 LHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPFFESLSWADLVQKKI 400 L L+L P ++ A +L++LL+++ +RLGA D E+Q HPFF ++W +L+ +K+ Sbjct: 306 LKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKV 365 Query: 401 PPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 459 PPF P + +D+ FD+ FT +T P S D S ++ S A+ F+GF+Y PS Sbjct: 366 EPPFKPLLQSEEDVSQFDSKFTRQT-PVD---SPDDSTLSES---ANQVFLGFTYVAPS 417 >gi|4885563 protein kinase C, epsilon [Homo sapiens] Length = 737 Score = 240 bits (612), Expect = 2e-63 Identities = 133/330 (40%), Positives = 188/330 (56%), Gaps = 41/330 (12%) Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220 +F+F+KV+GKGSFGKV+LA+ K + YAVKVL+K ++L + M E+ +L KH Sbjct: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466 Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280 P+L L+ FQT ++L+FV+++VNGG+L F +QR R F E R+RFYAAE+ SAL +LH Sbjct: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526 Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325 ++YRDLK +NILLD+ GH L DFG+CKEGI TTTTFCGTP Sbjct: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586 Query: 326 -----------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 368 +PPF + +++++ILH + +S A SIL+ + K+ Sbjct: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646 Query: 369 QNRLG---AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 425 RLG ++ I+ HPFF+ + W L QKKI PPF P + D+ NFD FT E Sbjct: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706 Query: 426 VPYSVCVSSDYSIVNASVLEADDAFVGFSY 455 ++ + +N + F GFSY Sbjct: 707 PVLTLVDEAIVKQIN------QEEFKGFSY 730 >gi|28557781 protein kinase C, eta [Homo sapiens] Length = 683 Score = 233 bits (593), Expect = 4e-61 Identities = 133/355 (37%), Positives = 189/355 (53%), Gaps = 40/355 (11%) Query: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKI 197 Q S+ + +G + + +F+F++V+GKGSFGKV+LA+ K G YAVKVL+K + Sbjct: 331 QGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDV 390 Query: 198 VLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERS 257 +L + + M E+ +L HPFL L FQT ++L+FV++FVNGG+L FH+Q+ R Sbjct: 391 ILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR 450 Query: 258 FPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDT 317 F E RARFYAAEI SAL +LH I+YRDLK +N+LLD GH L DFG+CKEGI T Sbjct: 451 FDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVT 510 Query: 318 TTTFCGTPE--------------------------------PPFYCRDVAEMYDNILHKP 345 T TFCGTP+ PF + ++++ IL+ Sbjct: 511 TATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDE 570 Query: 346 LSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLE--IQNHPFFESLSWADLVQKKIPPP 403 + + A IL+ + K+ RLG+ E I HPFF+ + WA L ++I PP Sbjct: 571 VVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPP 630 Query: 404 FNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458 F P + +D+ NFD F +E + ++N D F FSY P Sbjct: 631 FRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMIN------QDEFRNFSYVSP 679 >gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] Length = 409 Score = 233 bits (593), Expect = 4e-61 Identities = 132/339 (38%), Positives = 191/339 (56%), Gaps = 47/339 (13%) Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220 DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + + Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127 Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280 PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187 Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325 I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247 Query: 326 -----------------EPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 361 PF D +M + IL KP+ + +S+ A +L+ Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307 Query: 362 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 419 L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367 Query: 420 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458 FT E P + + +I E F GF Y P Sbjct: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400 >gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] Length = 409 Score = 233 bits (593), Expect = 4e-61 Identities = 132/339 (38%), Positives = 191/339 (56%), Gaps = 47/339 (13%) Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220 DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + + Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127 Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280 PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187 Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325 I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247 Query: 326 -----------------EPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 361 PF D +M + IL KP+ + +S+ A +L+ Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307 Query: 362 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 419 L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367 Query: 420 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458 FT E P + + +I E F GF Y P Sbjct: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400 >gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] Length = 592 Score = 233 bits (593), Expect = 4e-61 Identities = 132/339 (38%), Positives = 191/339 (56%), Gaps = 47/339 (13%) Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220 DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + + Sbjct: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310 Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280 PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH Sbjct: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370 Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325 I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP Sbjct: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430 Query: 326 -----------------EPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 361 PF D +M + IL KP+ + +S+ A +L+ Sbjct: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490 Query: 362 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 419 L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT Sbjct: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550 Query: 420 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458 FT E P + + +I E F GF Y P Sbjct: 551 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 583 >gi|4506067 protein kinase C, alpha [Homo sapiens] Length = 672 Score = 231 bits (589), Expect = 1e-60 Identities = 140/391 (35%), Positives = 203/391 (51%), Gaps = 56/391 (14%) Query: 117 LQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKP----------------T 160 L + ++ + P + DE + +L + LGP+GN P T Sbjct: 278 LNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT 337 Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220 DF+FL V+GKGSFGKV+LA RK + YA+K+L+K +V+ + + M E+ VL K Sbjct: 338 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 397 Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280 PFL LH FQT ++LYFV+++VNGG+L +H+Q+ F E +A FYAAEI+ L +LH Sbjct: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457 Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325 I+YRDLK +N++LDS GH+ + DFG+CKE + TT TFCGTP Sbjct: 458 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK 517 Query: 326 -----------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 368 +PPF D E++ +I+ +S +S A SI + L+ K Sbjct: 518 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP 577 Query: 369 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVP 427 RLG E +++ H FF + W L ++I PPF P V G NFD FT Sbjct: 578 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCG-KGAENFDKFFTRG--- 633 Query: 428 YSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458 ++ +V A++ ++D F GFSY P Sbjct: 634 -QPVLTPPDQLVIANIDQSD--FEGFSYVNP 661 >gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] Length = 671 Score = 221 bits (563), Expect = 1e-57 Identities = 129/334 (38%), Positives = 181/334 (54%), Gaps = 39/334 (11%) Query: 158 KPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKN 217 K TDF+FL V+GKGSFGKV+L++RK + YAVK+L+K +V+ + + M E+ VL Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 Query: 218 VKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYL 277 K PFL LH FQT ++LYFV+++VNGG+L +H+Q+ F E A FYAAEIA L +L Sbjct: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 Query: 278 HSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP------------ 325 S I+YRDLK +N++LDS GH+ + DFG+CKE I TT TFCGTP Sbjct: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 Query: 326 --------------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLE 365 + PF D E++ +I+ ++ +S A +I + L+ Sbjct: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577 Query: 366 KDRQNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 424 K RLG E +I+ H FF + W L +K+I PP+ P D NFD FT + Sbjct: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQ 637 Query: 425 TVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458 P + + I+N + F GFSY P Sbjct: 638 --PVELTPTDKLFIMNLD----QNEFAGFSYTNP 665 >gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform b [Homo sapiens] Length = 744 Score = 221 bits (562), Expect = 1e-57 Identities = 137/340 (40%), Positives = 182/340 (53%), Gaps = 42/340 (12%) Query: 122 PKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK- 180 P S P D DE +++ T +G+ A P+ F+ LKV+G+GSFGKV L + Sbjct: 35 PGPGSGPQRDSDEGVLKEISITHHV----KAGSEKADPSHFELLKVLGQGSFGKVFLVRK 90 Query: 181 --RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYF 238 R G YA+KVL KK L +++ ER++L +V HPF+V LHY+FQT KLY Sbjct: 91 VTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILA-DVNHPFVVKLHYAFQTEGKLYL 148 Query: 239 VLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVG 298 +LDF+ GG+LF L +E F E +FY AE+A L +LHS+ I+YRDLKPENILLD G Sbjct: 149 ILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEG 208 Query: 299 HVVLTDFGLCKEGIAISDTTTTFCGTPE-------------------------------- 326 H+ LTDFGL KE I +FCGT E Sbjct: 209 HIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGS 268 Query: 327 PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EIQNHP 385 PF +D E IL L + +S A S+L L +++ NRLG+ D EI+ H Sbjct: 269 LPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV 328 Query: 386 FFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 425 F+ ++ W L +++I PPF P VA PDD FDT FT T Sbjct: 329 FYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRT 368 Score = 75.9 bits (185), Expect = 7e-14 Identities = 52/163 (31%), Positives = 80/163 (49%), Gaps = 11/163 (6%) Query: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225 + IG GS+ + K YAVKV+ K ++ E +LL+ +HP ++ Sbjct: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 483 Query: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285 L + + +Y V + + GGEL + R++ F E A F I + YLHS +V+R Sbjct: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543 Query: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGT 324 DLKP NIL +D G+ + + DFG K+ A + T C T Sbjct: 544 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYT 586 >gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo sapiens] Length = 740 Score = 218 bits (555), Expect = 9e-57 Identities = 143/380 (37%), Positives = 197/380 (51%), Gaps = 52/380 (13%) Query: 119 MDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLL 178 MD P + + + +E S +++ T G+ A P+ F+ LKV+G+GSFGKV L Sbjct: 29 MDEPMGEEEINPQTEEVSIKEIAITHHV----KEGHEKADPSQFELLKVLGQGSFGKVFL 84 Query: 179 AKRKLDG----KFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTE 234 K K+ G + YA+KVL KK L +++ ER++L++ V HPF+V LHY+FQT Sbjct: 85 VK-KISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDILVE-VNHPFIVKLHYAFQTEG 141 Query: 235 KLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILL 294 KLY +LDF+ GG+LF L +E F E +FY AE+A AL +LHS+ I+YRDLKPENILL Sbjct: 142 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL 201 Query: 295 DSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE---------------------------- 326 D GH+ LTDFGL KE I +FCGT E Sbjct: 202 DEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEM 261 Query: 327 ----PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EI 381 PF +D E IL L + +S A S+L L +++ NRLGA D + EI Sbjct: 262 LTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEI 321 Query: 382 QNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNA 441 + H FF ++ W L +++I PPF P P+D FD FT +T S + Sbjct: 322 KRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPS------ 375 Query: 442 SVLEADDAFVGFSYAPPSED 461 A F GFS+ + D Sbjct: 376 --ANAHQLFRGFSFVAITSD 393 Score = 67.8 bits (164), Expect = 2e-11 Identities = 48/161 (29%), Positives = 77/161 (47%), Gaps = 11/161 (6%) Query: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLH 227 IG GS+ K +AVK++ K ++ E +LL+ +HP ++ L Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480 Query: 228 YSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDL 287 + + +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540 Query: 288 KPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGT 324 KP NIL +D G+ + + DFG K+ A + T C T Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYT 581 >gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform a [Homo sapiens] Length = 735 Score = 218 bits (554), Expect = 1e-56 Identities = 130/310 (41%), Positives = 172/310 (55%), Gaps = 38/310 (12%) Query: 152 SGNPHAKPTDFDFLKVIGKGSFGKVLLAK---RKLDGKFYAVKVLQKKIVLNRKEQKHIM 208 +G+ A P+ F+ LKV+G+GSFGKV L + R G YA+KVL KK L +++ Sbjct: 52 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 110 Query: 209 AERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAA 268 ER++L +V HPF+V LHY+FQT KLY +LDF+ GG+LF L +E F E +FY A Sbjct: 111 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 169 Query: 269 EIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE-- 326 E+A L +LHS+ I+YRDLKPENILLD GH+ LTDFGL KE I +FCGT E Sbjct: 170 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 229 Query: 327 ------------------------------PPFYCRDVAEMYDNILHKPLSLRPGVSLTA 356 PF +D E IL L + +S A Sbjct: 230 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 289 Query: 357 WSILEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIR 415 S+L L +++ NRLG+ D EI+ H F+ ++ W L +++I PPF P VA PDD Sbjct: 290 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 349 Query: 416 NFDTAFTEET 425 FDT FT T Sbjct: 350 YFDTEFTSRT 359 Score = 75.9 bits (185), Expect = 7e-14 Identities = 52/163 (31%), Positives = 80/163 (49%), Gaps = 11/163 (6%) Query: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225 + IG GS+ + K YAVKV+ K ++ E +LL+ +HP ++ Sbjct: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 474 Query: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285 L + + +Y V + + GGEL + R++ F E A F I + YLHS +V+R Sbjct: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534 Query: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGT 324 DLKP NIL +D G+ + + DFG K+ A + T C T Sbjct: 535 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYT 577 >gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] Length = 745 Score = 217 bits (553), Expect = 2e-56 Identities = 141/383 (36%), Positives = 196/383 (51%), Gaps = 50/383 (13%) Query: 112 DVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKG 171 +V +D P + + DE +++ T G A P F+ LKV+G+G Sbjct: 27 EVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHV----KEGYEKADPAQFELLKVLGQG 82 Query: 172 SFGKVLLAKRKLD---GKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228 SFGKV L ++K G+ YA+KVL KK L +++ ER++L++ V HPF+V LHY Sbjct: 83 SFGKVFLVRKKTGPDAGQLYAMKVL-KKASLKVRDRVRTKMERDILVE-VNHPFIVKLHY 140 Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288 +FQT KLY +LDF+ GG++F L +E F E +FY AE+A AL +LH + IVYRDLK Sbjct: 141 AFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLK 200 Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE---------------------- 326 PENILLD +GH+ LTDFGL KE + +FCGT E Sbjct: 201 PENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYG 260 Query: 327 ----------PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKE 376 PF +D E + IL L + +S A S+L L +++ NRLG+ E Sbjct: 261 VLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS-E 319 Query: 377 DFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDY 436 EI+ H FF ++ W L ++++ PPF P PDD FD FT +T D Sbjct: 320 GVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKT-------PKDS 372 Query: 437 SIVNASVLEADDAFVGFSYAPPS 459 + AS A F GFS+ S Sbjct: 373 PGLPASA-NAHQLFKGFSFVATS 394 Score = 64.7 bits (156), Expect = 2e-10 Identities = 42/153 (27%), Positives = 70/153 (45%), Gaps = 11/153 (7%) Query: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221 ++ + IG GS+ +AVK++ K ++ E +L++ +HP Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKS-------KRDPSEEIEILMRYGQHP 478 Query: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281 ++ L F +Y V D + GGEL + +++ F E A I+ + YLH Sbjct: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538 Query: 282 IVYRDLKPENILL----DSVGHVVLTDFGLCKE 310 +V+RDLKP NIL S + + DFG K+ Sbjct: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQ 571 >gi|5453974 protein kinase N2 [Homo sapiens] Length = 984 Score = 214 bits (545), Expect = 1e-55 Identities = 130/352 (36%), Positives = 186/352 (52%), Gaps = 54/352 (15%) Query: 111 PDVRAFLQMDSPK---HQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKV 167 P ++ + D+P+ S E ED RS Q+ Q DF V Sbjct: 618 PKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQ---------------DFRCCAV 662 Query: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVL--LKNVKHPFLVG 225 +G+G FGKVLLA+ K + +A+K L+K ++ R E +M E+ + + +V+HPFLV Sbjct: 663 LGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 722 Query: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285 L FQT E + FV+++ GG+L H+ + F E RA FYAA + L YLH KIVYR Sbjct: 723 LFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYR 781 Query: 286 DLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP-------------------- 325 DLK +N+LLD+ G V + DFGLCKEG+ D T+TFCGTP Sbjct: 782 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWW 841 Query: 326 ------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLG 373 E PF D E++D+I++ + +S A SI+ LL ++ + RLG Sbjct: 842 GLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLG 901 Query: 374 AKE-DFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 424 A E D +++ HPFF + W+ L+ KK+ PPF P + G +D+ NFD FT E Sbjct: 902 ASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSE 953 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.138 0.412 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,946,361 Number of Sequences: 37866 Number of extensions: 859285 Number of successful extensions: 3895 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 709 Number of HSP's successfully gapped in prelim test: 108 Number of HSP's that attempted gapping in prelim test: 2203 Number of HSP's gapped (non-prelim): 1086 length of query: 464 length of database: 18,247,518 effective HSP length: 106 effective length of query: 358 effective length of database: 14,233,722 effective search space: 5095672476 effective search space used: 5095672476 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.