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Search of human proteins with 31563383
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2
[Homo sapiens]
(464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 946 0.0
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 929 0.0
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 929 0.0
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 497 e-141
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 487 e-138
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 487 e-138
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 487 e-138
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 434 e-122
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 434 e-122
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 275 6e-74
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 275 8e-74
gi|4502023 AKT2 kinase [Homo sapiens] 268 1e-71
gi|62241015 AKT1 kinase [Homo sapiens] 255 7e-68
gi|62241013 AKT1 kinase [Homo sapiens] 255 7e-68
gi|62241011 AKT1 kinase [Homo sapiens] 255 7e-68
gi|133908623 protein kinase C, iota [Homo sapiens] 249 4e-66
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 244 9e-65
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 243 3e-64
gi|4885563 protein kinase C, epsilon [Homo sapiens] 240 2e-63
gi|28557781 protein kinase C, eta [Homo sapiens] 233 4e-61
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 233 4e-61
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 233 4e-61
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 233 4e-61
gi|4506067 protein kinase C, alpha [Homo sapiens] 231 1e-60
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 221 1e-57
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 221 1e-57
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 218 9e-57
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 218 1e-56
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 217 2e-56
gi|5453974 protein kinase N2 [Homo sapiens] 214 1e-55
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 946 bits (2444), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
Sbjct: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
Query: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
Sbjct: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPEPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL 360
VLTDFGLCKEGIAISDTTTTFCGTPEPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL
Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPEPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL 360
Query: 361 EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTA 420
EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTA
Sbjct: 361 EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTA 420
Query: 421 FTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL 464
FTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL
Sbjct: 421 FTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL 464
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 929 bits (2401), Expect = 0.0
Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%)
Query: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
Sbjct: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
Query: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
Sbjct: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPE--------------------------------PP 328
VLTDFGLCKEGIAISDTTTTFCGTPE PP
Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP 360
Query: 329 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 388
FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE
Sbjct: 361 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420
Query: 389 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 448
SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD
Sbjct: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 480
Query: 449 AFVGFSYAPPSEDLFL 464
AFVGFSYAPPSEDLFL
Sbjct: 481 AFVGFSYAPPSEDLFL 496
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 929 bits (2401), Expect = 0.0
Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%)
Query: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
Sbjct: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
Query: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
Sbjct: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPE--------------------------------PP 328
VLTDFGLCKEGIAISDTTTTFCGTPE PP
Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP 360
Query: 329 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 388
FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE
Sbjct: 361 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420
Query: 389 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 448
SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD
Sbjct: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 480
Query: 449 AFVGFSYAPPSEDLFL 464
AFVGFSYAPPSEDLFL
Sbjct: 481 AFVGFSYAPPSEDLFL 496
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 497 bits (1280), Expect = e-141
Identities = 256/430 (59%), Positives = 308/430 (71%), Gaps = 45/430 (10%)
Query: 67 AMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH-- 124
A L P R F N DP F+KQRR GLN+FIQ + HP+V++ L++ P+
Sbjct: 103 ANILTKPDPRTFWTNDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPE 162
Query: 125 --QSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRK 182
++PS S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K
Sbjct: 163 LMNANPSPPP---------SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 213
Query: 183 LDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDF 242
+ FYAVKVLQKK +L +KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD+
Sbjct: 214 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 273
Query: 243 VNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVL 302
+NGGELF+HLQRER F E RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VL
Sbjct: 274 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVL 333
Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330
TDFGLCKE I + TT+TFCGTPE PPFY
Sbjct: 334 TDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY 393
Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESL 390
R+ AEMYDNIL+KPL L+P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF +
Sbjct: 394 SRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLI 453
Query: 391 SWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAF 450
+W DL+ KKI PPFNPNV+GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF
Sbjct: 454 NWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAF 513
Query: 451 VGFSYAPPSE 460
+GFSYAPP++
Sbjct: 514 LGFSYAPPTD 523
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 487 bits (1254), Expect = e-138
Identities = 248/411 (60%), Positives = 300/411 (72%), Gaps = 45/411 (10%)
Query: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 27 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 77
Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 78 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 137
Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 138 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 197
Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 198 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 257
Query: 322 CGTPE--------------------------------PPFYCRDVAEMYDNILHKPLSLR 349
CGTPE PPFY R+ AEMYDNIL+KPL L+
Sbjct: 258 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 317
Query: 350 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 409
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 318 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 377
Query: 410 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 460
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 378 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 428
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 487 bits (1254), Expect = e-138
Identities = 248/411 (60%), Positives = 300/411 (72%), Gaps = 45/411 (10%)
Query: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 41 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 91
Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 92 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 151
Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 152 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 211
Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 212 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 271
Query: 322 CGTPE--------------------------------PPFYCRDVAEMYDNILHKPLSLR 349
CGTPE PPFY R+ AEMYDNIL+KPL L+
Sbjct: 272 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 331
Query: 350 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 409
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 332 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 391
Query: 410 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 460
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 392 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 442
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 487 bits (1254), Expect = e-138
Identities = 248/411 (60%), Positives = 300/411 (72%), Gaps = 45/411 (10%)
Query: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 55 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 105
Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 106 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 165
Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 166 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 225
Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 226 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 285
Query: 322 CGTPE--------------------------------PPFYCRDVAEMYDNILHKPLSLR 349
CGTPE PPFY R+ AEMYDNIL+KPL L+
Sbjct: 286 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 345
Query: 350 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 409
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 346 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 405
Query: 410 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 460
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 406 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 456
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 434 bits (1117), Expect = e-122
Identities = 217/349 (62%), Positives = 259/349 (74%), Gaps = 35/349 (10%)
Query: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ
Sbjct: 19 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 78
Query: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 79 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 138
Query: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP
Sbjct: 139 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 198
Query: 326 E--------------------------------PPFYCRDVAEMYDNILHKPLSLRPGVS 353
E PPFY +DV++MY+NILH+PL + G +
Sbjct: 199 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 258
Query: 354 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 413
+ A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D
Sbjct: 259 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 318
Query: 414 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 462
+++FD FT+E V S+ + D AS A AF+GFSYAP +D+
Sbjct: 319 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 364
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 434 bits (1117), Expect = e-122
Identities = 217/349 (62%), Positives = 259/349 (74%), Gaps = 35/349 (10%)
Query: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ
Sbjct: 79 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 138
Query: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 139 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 198
Query: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP
Sbjct: 199 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 258
Query: 326 E--------------------------------PPFYCRDVAEMYDNILHKPLSLRPGVS 353
E PPFY +DV++MY+NILH+PL + G +
Sbjct: 259 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 318
Query: 354 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 413
+ A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D
Sbjct: 319 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 378
Query: 414 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 462
+++FD FT+E V S+ + D AS A AF+GFSYAP +D+
Sbjct: 379 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 424
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 275 bits (703), Expect = 6e-74
Identities = 162/401 (40%), Positives = 219/401 (54%), Gaps = 58/401 (14%)
Query: 87 IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137
+K R N FI +++ + + +D+P+ + + +E E
Sbjct: 62 MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116
Query: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190
TSQ N+G S H + T DFD+LK++GKG+FGKV+L + K GK+YA+
Sbjct: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176
Query: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250
K+L+K++++ + E H + E VL KN +HPFL L YSFQT ++L FV+++VNGGELFF
Sbjct: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
Query: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310
HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD GH+ +TDFGLCKE
Sbjct: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
Query: 311 GIAISDTTTTFCGTPE--------------------------------PPFYCRDVAEMY 338
GI + T TFCGTPE PFY +D +++
Sbjct: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
Query: 339 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 397
+ IL + + +S A S+L LL KD RL G +D EI H FF ++W D+
Sbjct: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
Query: 398 KKIPPPFNPNVAGPDDIRNFDTAFTEETV---PYSVCVSSD 435
KK+ PPF P V D R FD FT +T+ P C SD
Sbjct: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 275 bits (702), Expect = 8e-74
Identities = 164/419 (39%), Positives = 225/419 (53%), Gaps = 55/419 (13%)
Query: 87 IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137
+K R N FI +++ + + +D+P+ + + +E E
Sbjct: 62 MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116
Query: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190
TSQ N+G S H + T DFD+LK++GKG+FGKV+L + K GK+YA+
Sbjct: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176
Query: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250
K+L+K++++ + E H + E VL KN +HPFL L YSFQT ++L FV+++VNGGELFF
Sbjct: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
Query: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310
HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD GH+ +TDFGLCKE
Sbjct: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
Query: 311 GIAISDTTTTFCGTPE--------------------------------PPFYCRDVAEMY 338
GI + T TFCGTPE PFY +D +++
Sbjct: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
Query: 339 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 397
+ IL + + +S A S+L LL KD RL G +D EI H FF ++W D+
Sbjct: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
Query: 398 KKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYA 456
KK+ PPF P V D R FD FT +T+ + D ++ E F FSY+
Sbjct: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYS 474
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 268 bits (684), Expect = 1e-71
Identities = 155/381 (40%), Positives = 219/381 (57%), Gaps = 41/381 (10%)
Query: 113 VRAFLQMDSPKHQSDPSED--EDERSSQKLHSTSQNINLGPSGNPHAKPT--DFDFLKVI 168
+RA + + Q P ED + + S ST++ + + S AK T DFD+LK++
Sbjct: 100 MRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVS-KARAKVTMNDFDYLKLL 158
Query: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
GKG+FGKV+L + K G++YA+K+L+K++++ + E H + E VL +N +HPFL L Y
Sbjct: 159 GKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKY 217
Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
+FQT ++L FV+++ NGGELFFHL RER F E RARFY AEI SAL YLHS +VYRD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE---------------------- 326
EN++LD GH+ +TDFGLCKEGI+ T TFCGTPE
Sbjct: 278 LENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG 337
Query: 327 ----------PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAK 375
PFY +D +++ IL + + +S A S+L LL+KD + RL G
Sbjct: 338 VVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGP 397
Query: 376 EDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSD 435
D E+ H FF S++W D+VQKK+ PPF P V D R FD FT +++ ++
Sbjct: 398 SDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI--TITPPDR 455
Query: 436 YSIVNASVLEADDAFVGFSYA 456
Y + L+ F FSY+
Sbjct: 456 YDSLGLLELDQRTHFPQFSYS 476
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 255 bits (651), Expect = 7e-68
Identities = 143/337 (42%), Positives = 193/337 (57%), Gaps = 41/337 (12%)
Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183
+ E+E + S S N AKP +F++LK++GKG+FGKV+L K K
Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171
Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243
G++YA+K+L+K++++ + E H + E VL +N +HPFL L YSFQT ++L FV+++
Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230
Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302
NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD GH+ +
Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330
TDFGLCKEGI T TFCGTPE PFY
Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350
Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 389
+D ++++ IL + + + A S+L LL+KD + RL G ED EI H FF
Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410
Query: 390 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 426
+ W + +KK+ PPF P V D R FD FT + +
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 255 bits (651), Expect = 7e-68
Identities = 143/337 (42%), Positives = 193/337 (57%), Gaps = 41/337 (12%)
Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183
+ E+E + S S N AKP +F++LK++GKG+FGKV+L K K
Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171
Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243
G++YA+K+L+K++++ + E H + E VL +N +HPFL L YSFQT ++L FV+++
Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230
Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302
NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD GH+ +
Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330
TDFGLCKEGI T TFCGTPE PFY
Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350
Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 389
+D ++++ IL + + + A S+L LL+KD + RL G ED EI H FF
Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410
Query: 390 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 426
+ W + +KK+ PPF P V D R FD FT + +
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 255 bits (651), Expect = 7e-68
Identities = 143/337 (42%), Positives = 193/337 (57%), Gaps = 41/337 (12%)
Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183
+ E+E + S S N AKP +F++LK++GKG+FGKV+L K K
Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171
Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243
G++YA+K+L+K++++ + E H + E VL +N +HPFL L YSFQT ++L FV+++
Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230
Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302
NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD GH+ +
Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330
TDFGLCKEGI T TFCGTPE PFY
Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350
Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 389
+D ++++ IL + + + A S+L LL+KD + RL G ED EI H FF
Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410
Query: 390 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 426
+ W + +KK+ PPF P V D R FD FT + +
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 249 bits (636), Expect = 4e-66
Identities = 148/396 (37%), Positives = 209/396 (52%), Gaps = 63/396 (15%)
Query: 117 LQMDSPKHQSD------PSEDEDERSSQKLHSTSQNINLGPSGNPHAKP--TDFDFLKVI 168
+ MD SD P S ++ + +N SG + DFD L+VI
Sbjct: 201 MPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260
Query: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
G+GS+ KVLL + K + YA+KV++K++V + ++ + E++V + HPFLVGLH
Sbjct: 261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS 320
Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
FQT +L+FV+++VNGG+L FH+QR+R PE ARFY+AEI+ AL YLH I+YRDLK
Sbjct: 321 CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 380
Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP----------------------- 325
+N+LLDS GH+ LTD+G+CKEG+ DTT+TFCGTP
Sbjct: 381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 440
Query: 326 ---------EPPFYCRDVAEMYDN------------ILHKPLSLRPGVSLTAWSILEELL 364
PF D+ DN IL K + + +S+ A S+L+ L
Sbjct: 441 VLMFEMMAGRSPF---DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 497
Query: 365 EKDRQNRLGA--KEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFT 422
KD + RLG + F +IQ HPFF ++ W + QK++ PPF PN++G + NFD+ FT
Sbjct: 498 NKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFT 557
Query: 423 EETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
E V + D IV F GF Y P
Sbjct: 558 NEPVQLT---PDDDDIVRKI---DQSEFEGFEYINP 587
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 244 bits (624), Expect = 9e-65
Identities = 147/360 (40%), Positives = 207/360 (57%), Gaps = 50/360 (13%)
Query: 138 QKLHSTSQNINLGPSG-NPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVL 193
+++ T ++N+GP PH F+ L+V+GKG +GKV ++ GK YA+KVL
Sbjct: 46 EEVELTETSVNVGPERIGPHC----FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVL 101
Query: 194 QK-KIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHL 252
+K KIV N K+ H AERN+L ++VKHPF+V L Y+FQT KLY +L+ ++GGELF HL
Sbjct: 102 RKAKIVRNAKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHL 160
Query: 253 QRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGI 312
+RE F E A FY AEI ALG+LHS I+YRDLKPENI+L S GH+ LTDFGLCKE I
Sbjct: 161 EREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI 220
Query: 313 AISDTTTTFCGTPE--------------------------------PPFYCRDVAEMYDN 340
T TFCGT E PPF + + D
Sbjct: 221 HEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDK 280
Query: 341 ILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQKK 399
I+ L+L P ++ A ++++ L+++ R+ G D ++Q HPFF ++W DL+ +
Sbjct: 281 IIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWR 340
Query: 400 IPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 459
+ PPF P + +D+ FDT FT +T P S D + ++ S A+ AF+GF+Y PS
Sbjct: 341 VDPPFRPCLQSEEDVSQFDTRFTRQT-PVD---SPDDTALSES---ANQAFLGFTYVAPS 393
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 243 bits (619), Expect = 3e-64
Identities = 147/359 (40%), Positives = 206/359 (57%), Gaps = 48/359 (13%)
Query: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVLQ 194
+K + ++N GP +P F+ L+V+GKG +GKV ++ GK +A+KVL+
Sbjct: 70 EKFEISETSVNRGPE---KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK 126
Query: 195 KK-IVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ 253
K IV N K+ H AERN+L + VKHPF+V L Y+FQT KLY +L++++GGELF L+
Sbjct: 127 KAMIVRNAKDTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLE 185
Query: 254 RERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIA 313
RE F E A FY AEI+ ALG+LH I+YRDLKPENI+L+ GHV LTDFGLCKE I
Sbjct: 186 REGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIH 245
Query: 314 ISDTTTTFCGTPE--------------------------------PPFYCRDVAEMYDNI 341
T TFCGT E PPF + + D I
Sbjct: 246 DGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKI 305
Query: 342 LHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPFFESLSWADLVQKKI 400
L L+L P ++ A +L++LL+++ +RLGA D E+Q HPFF ++W +L+ +K+
Sbjct: 306 LKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKV 365
Query: 401 PPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 459
PPF P + +D+ FD+ FT +T P S D S ++ S A+ F+GF+Y PS
Sbjct: 366 EPPFKPLLQSEEDVSQFDSKFTRQT-PVD---SPDDSTLSES---ANQVFLGFTYVAPS 417
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 240 bits (612), Expect = 2e-63
Identities = 133/330 (40%), Positives = 188/330 (56%), Gaps = 41/330 (12%)
Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
+F+F+KV+GKGSFGKV+LA+ K + YAVKVL+K ++L + M E+ +L KH
Sbjct: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466
Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
P+L L+ FQT ++L+FV+++VNGG+L F +QR R F E R+RFYAAE+ SAL +LH
Sbjct: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526
Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325
++YRDLK +NILLD+ GH L DFG+CKEGI TTTTFCGTP
Sbjct: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586
Query: 326 -----------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 368
+PPF + +++++ILH + +S A SIL+ + K+
Sbjct: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646
Query: 369 QNRLG---AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 425
RLG ++ I+ HPFF+ + W L QKKI PPF P + D+ NFD FT E
Sbjct: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706
Query: 426 VPYSVCVSSDYSIVNASVLEADDAFVGFSY 455
++ + +N + F GFSY
Sbjct: 707 PVLTLVDEAIVKQIN------QEEFKGFSY 730
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 233 bits (593), Expect = 4e-61
Identities = 133/355 (37%), Positives = 189/355 (53%), Gaps = 40/355 (11%)
Query: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKI 197
Q S+ + +G + + +F+F++V+GKGSFGKV+LA+ K G YAVKVL+K +
Sbjct: 331 QGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDV 390
Query: 198 VLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERS 257
+L + + M E+ +L HPFL L FQT ++L+FV++FVNGG+L FH+Q+ R
Sbjct: 391 ILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR 450
Query: 258 FPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDT 317
F E RARFYAAEI SAL +LH I+YRDLK +N+LLD GH L DFG+CKEGI T
Sbjct: 451 FDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVT 510
Query: 318 TTTFCGTPE--------------------------------PPFYCRDVAEMYDNILHKP 345
T TFCGTP+ PF + ++++ IL+
Sbjct: 511 TATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDE 570
Query: 346 LSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLE--IQNHPFFESLSWADLVQKKIPPP 403
+ + A IL+ + K+ RLG+ E I HPFF+ + WA L ++I PP
Sbjct: 571 VVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPP 630
Query: 404 FNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
F P + +D+ NFD F +E + ++N D F FSY P
Sbjct: 631 FRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMIN------QDEFRNFSYVSP 679
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 233 bits (593), Expect = 4e-61
Identities = 132/339 (38%), Positives = 191/339 (56%), Gaps = 47/339 (13%)
Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325
I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 326 -----------------EPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 361
PF D +M + IL KP+ + +S+ A +L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 362 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 419
L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 420 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
FT E P + + +I E F GF Y P
Sbjct: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 233 bits (593), Expect = 4e-61
Identities = 132/339 (38%), Positives = 191/339 (56%), Gaps = 47/339 (13%)
Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325
I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 326 -----------------EPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 361
PF D +M + IL KP+ + +S+ A +L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 362 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 419
L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 420 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
FT E P + + +I E F GF Y P
Sbjct: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 233 bits (593), Expect = 4e-61
Identities = 132/339 (38%), Positives = 191/339 (56%), Gaps = 47/339 (13%)
Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + +
Sbjct: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH
Sbjct: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325
I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP
Sbjct: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
Query: 326 -----------------EPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 361
PF D +M + IL KP+ + +S+ A +L+
Sbjct: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
Query: 362 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 419
L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT
Sbjct: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
Query: 420 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
FT E P + + +I E F GF Y P
Sbjct: 551 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 583
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 231 bits (589), Expect = 1e-60
Identities = 140/391 (35%), Positives = 203/391 (51%), Gaps = 56/391 (14%)
Query: 117 LQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKP----------------T 160
L + ++ + P + DE + +L + LGP+GN P T
Sbjct: 278 LNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT 337
Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
DF+FL V+GKGSFGKV+LA RK + YA+K+L+K +V+ + + M E+ VL K
Sbjct: 338 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 397
Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
PFL LH FQT ++LYFV+++VNGG+L +H+Q+ F E +A FYAAEI+ L +LH
Sbjct: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457
Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325
I+YRDLK +N++LDS GH+ + DFG+CKE + TT TFCGTP
Sbjct: 458 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK 517
Query: 326 -----------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 368
+PPF D E++ +I+ +S +S A SI + L+ K
Sbjct: 518 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP 577
Query: 369 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVP 427
RLG E +++ H FF + W L ++I PPF P V G NFD FT
Sbjct: 578 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCG-KGAENFDKFFTRG--- 633
Query: 428 YSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
++ +V A++ ++D F GFSY P
Sbjct: 634 -QPVLTPPDQLVIANIDQSD--FEGFSYVNP 661
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 221 bits (563), Expect = 1e-57
Identities = 129/334 (38%), Positives = 181/334 (54%), Gaps = 39/334 (11%)
Query: 158 KPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKN 217
K TDF+FL V+GKGSFGKV+L++RK + YAVK+L+K +V+ + + M E+ VL
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
Query: 218 VKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYL 277
K PFL LH FQT ++LYFV+++VNGG+L +H+Q+ F E A FYAAEIA L +L
Sbjct: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
Query: 278 HSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP------------ 325
S I+YRDLK +N++LDS GH+ + DFG+CKE I TT TFCGTP
Sbjct: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
Query: 326 --------------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLE 365
+ PF D E++ +I+ ++ +S A +I + L+
Sbjct: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
Query: 366 KDRQNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 424
K RLG E +I+ H FF + W L +K+I PP+ P D NFD FT +
Sbjct: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQ 637
Query: 425 TVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
P + + I+N + F GFSY P
Sbjct: 638 --PVELTPTDKLFIMNLD----QNEFAGFSYTNP 665
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 221 bits (562), Expect = 1e-57
Identities = 137/340 (40%), Positives = 182/340 (53%), Gaps = 42/340 (12%)
Query: 122 PKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK- 180
P S P D DE +++ T +G+ A P+ F+ LKV+G+GSFGKV L +
Sbjct: 35 PGPGSGPQRDSDEGVLKEISITHHV----KAGSEKADPSHFELLKVLGQGSFGKVFLVRK 90
Query: 181 --RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYF 238
R G YA+KVL KK L +++ ER++L +V HPF+V LHY+FQT KLY
Sbjct: 91 VTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILA-DVNHPFVVKLHYAFQTEGKLYL 148
Query: 239 VLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVG 298
+LDF+ GG+LF L +E F E +FY AE+A L +LHS+ I+YRDLKPENILLD G
Sbjct: 149 ILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEG 208
Query: 299 HVVLTDFGLCKEGIAISDTTTTFCGTPE-------------------------------- 326
H+ LTDFGL KE I +FCGT E
Sbjct: 209 HIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGS 268
Query: 327 PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EIQNHP 385
PF +D E IL L + +S A S+L L +++ NRLG+ D EI+ H
Sbjct: 269 LPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV 328
Query: 386 FFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 425
F+ ++ W L +++I PPF P VA PDD FDT FT T
Sbjct: 329 FYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRT 368
Score = 75.9 bits (185), Expect = 7e-14
Identities = 52/163 (31%), Positives = 80/163 (49%), Gaps = 11/163 (6%)
Query: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
+ IG GS+ + K YAVKV+ K ++ E +LL+ +HP ++
Sbjct: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 483
Query: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
L + + +Y V + + GGEL + R++ F E A F I + YLHS +V+R
Sbjct: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543
Query: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGT 324
DLKP NIL +D G+ + + DFG K+ A + T C T
Sbjct: 544 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYT 586
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 218 bits (555), Expect = 9e-57
Identities = 143/380 (37%), Positives = 197/380 (51%), Gaps = 52/380 (13%)
Query: 119 MDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLL 178
MD P + + + +E S +++ T G+ A P+ F+ LKV+G+GSFGKV L
Sbjct: 29 MDEPMGEEEINPQTEEVSIKEIAITHHV----KEGHEKADPSQFELLKVLGQGSFGKVFL 84
Query: 179 AKRKLDG----KFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTE 234
K K+ G + YA+KVL KK L +++ ER++L++ V HPF+V LHY+FQT
Sbjct: 85 VK-KISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDILVE-VNHPFIVKLHYAFQTEG 141
Query: 235 KLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILL 294
KLY +LDF+ GG+LF L +E F E +FY AE+A AL +LHS+ I+YRDLKPENILL
Sbjct: 142 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL 201
Query: 295 DSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE---------------------------- 326
D GH+ LTDFGL KE I +FCGT E
Sbjct: 202 DEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEM 261
Query: 327 ----PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EI 381
PF +D E IL L + +S A S+L L +++ NRLGA D + EI
Sbjct: 262 LTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEI 321
Query: 382 QNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNA 441
+ H FF ++ W L +++I PPF P P+D FD FT +T S +
Sbjct: 322 KRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPS------ 375
Query: 442 SVLEADDAFVGFSYAPPSED 461
A F GFS+ + D
Sbjct: 376 --ANAHQLFRGFSFVAITSD 393
Score = 67.8 bits (164), Expect = 2e-11
Identities = 48/161 (29%), Positives = 77/161 (47%), Gaps = 11/161 (6%)
Query: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLH 227
IG GS+ K +AVK++ K ++ E +LL+ +HP ++ L
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480
Query: 228 YSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDL 287
+ + +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
Query: 288 KPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGT 324
KP NIL +D G+ + + DFG K+ A + T C T
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYT 581
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 218 bits (554), Expect = 1e-56
Identities = 130/310 (41%), Positives = 172/310 (55%), Gaps = 38/310 (12%)
Query: 152 SGNPHAKPTDFDFLKVIGKGSFGKVLLAK---RKLDGKFYAVKVLQKKIVLNRKEQKHIM 208
+G+ A P+ F+ LKV+G+GSFGKV L + R G YA+KVL KK L +++
Sbjct: 52 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 110
Query: 209 AERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAA 268
ER++L +V HPF+V LHY+FQT KLY +LDF+ GG+LF L +E F E +FY A
Sbjct: 111 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 169
Query: 269 EIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE-- 326
E+A L +LHS+ I+YRDLKPENILLD GH+ LTDFGL KE I +FCGT E
Sbjct: 170 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 229
Query: 327 ------------------------------PPFYCRDVAEMYDNILHKPLSLRPGVSLTA 356
PF +D E IL L + +S A
Sbjct: 230 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 289
Query: 357 WSILEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIR 415
S+L L +++ NRLG+ D EI+ H F+ ++ W L +++I PPF P VA PDD
Sbjct: 290 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 349
Query: 416 NFDTAFTEET 425
FDT FT T
Sbjct: 350 YFDTEFTSRT 359
Score = 75.9 bits (185), Expect = 7e-14
Identities = 52/163 (31%), Positives = 80/163 (49%), Gaps = 11/163 (6%)
Query: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
+ IG GS+ + K YAVKV+ K ++ E +LL+ +HP ++
Sbjct: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 474
Query: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
L + + +Y V + + GGEL + R++ F E A F I + YLHS +V+R
Sbjct: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534
Query: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGT 324
DLKP NIL +D G+ + + DFG K+ A + T C T
Sbjct: 535 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYT 577
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 217 bits (553), Expect = 2e-56
Identities = 141/383 (36%), Positives = 196/383 (51%), Gaps = 50/383 (13%)
Query: 112 DVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKG 171
+V +D P + + DE +++ T G A P F+ LKV+G+G
Sbjct: 27 EVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHV----KEGYEKADPAQFELLKVLGQG 82
Query: 172 SFGKVLLAKRKLD---GKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
SFGKV L ++K G+ YA+KVL KK L +++ ER++L++ V HPF+V LHY
Sbjct: 83 SFGKVFLVRKKTGPDAGQLYAMKVL-KKASLKVRDRVRTKMERDILVE-VNHPFIVKLHY 140
Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
+FQT KLY +LDF+ GG++F L +E F E +FY AE+A AL +LH + IVYRDLK
Sbjct: 141 AFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLK 200
Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE---------------------- 326
PENILLD +GH+ LTDFGL KE + +FCGT E
Sbjct: 201 PENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYG 260
Query: 327 ----------PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKE 376
PF +D E + IL L + +S A S+L L +++ NRLG+ E
Sbjct: 261 VLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS-E 319
Query: 377 DFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDY 436
EI+ H FF ++ W L ++++ PPF P PDD FD FT +T D
Sbjct: 320 GVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKT-------PKDS 372
Query: 437 SIVNASVLEADDAFVGFSYAPPS 459
+ AS A F GFS+ S
Sbjct: 373 PGLPASA-NAHQLFKGFSFVATS 394
Score = 64.7 bits (156), Expect = 2e-10
Identities = 42/153 (27%), Positives = 70/153 (45%), Gaps = 11/153 (7%)
Query: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221
++ + IG GS+ +AVK++ K ++ E +L++ +HP
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKS-------KRDPSEEIEILMRYGQHP 478
Query: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281
++ L F +Y V D + GGEL + +++ F E A I+ + YLH
Sbjct: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538
Query: 282 IVYRDLKPENILL----DSVGHVVLTDFGLCKE 310
+V+RDLKP NIL S + + DFG K+
Sbjct: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQ 571
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 214 bits (545), Expect = 1e-55
Identities = 130/352 (36%), Positives = 186/352 (52%), Gaps = 54/352 (15%)
Query: 111 PDVRAFLQMDSPK---HQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKV 167
P ++ + D+P+ S E ED RS Q+ Q DF V
Sbjct: 618 PKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQ---------------DFRCCAV 662
Query: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVL--LKNVKHPFLVG 225
+G+G FGKVLLA+ K + +A+K L+K ++ R E +M E+ + + +V+HPFLV
Sbjct: 663 LGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 722
Query: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
L FQT E + FV+++ GG+L H+ + F E RA FYAA + L YLH KIVYR
Sbjct: 723 LFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYR 781
Query: 286 DLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP-------------------- 325
DLK +N+LLD+ G V + DFGLCKEG+ D T+TFCGTP
Sbjct: 782 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWW 841
Query: 326 ------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLG 373
E PF D E++D+I++ + +S A SI+ LL ++ + RLG
Sbjct: 842 GLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLG 901
Query: 374 AKE-DFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 424
A E D +++ HPFF + W+ L+ KK+ PPF P + G +D+ NFD FT E
Sbjct: 902 ASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSE 953
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,946,361
Number of Sequences: 37866
Number of extensions: 859285
Number of successful extensions: 3895
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 709
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 2203
Number of HSP's gapped (non-prelim): 1086
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.