Guide to the Human Genome
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Search of human proteins with 31563383

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2
[Homo sapiens]
         (464 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H...   946   0.0  
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   929   0.0  
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   929   0.0  
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   497   e-141
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   487   e-138
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   487   e-138
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   487   e-138
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   434   e-122
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   434   e-122
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      275   6e-74
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       275   8e-74
gi|4502023 AKT2 kinase [Homo sapiens]                                 268   1e-71
gi|62241015 AKT1 kinase [Homo sapiens]                                255   7e-68
gi|62241013 AKT1 kinase [Homo sapiens]                                255   7e-68
gi|62241011 AKT1 kinase [Homo sapiens]                                255   7e-68
gi|133908623 protein kinase C, iota [Homo sapiens]                    249   4e-66
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H...   244   9e-65
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho...   243   3e-64
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   240   2e-63
gi|28557781 protein kinase C, eta [Homo sapiens]                      233   4e-61
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]           233   4e-61
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]           233   4e-61
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]           233   4e-61
gi|4506067 protein kinase C, alpha [Homo sapiens]                     231   1e-60
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           221   1e-57
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   221   1e-57
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...   218   9e-57
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   218   1e-56
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   217   2e-56
gi|5453974 protein kinase N2 [Homo sapiens]                           214   1e-55

>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
           sapiens]
          Length = 464

 Score =  946 bits (2444), Expect = 0.0
 Identities = 464/464 (100%), Positives = 464/464 (100%)

Query: 1   MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
           MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
Sbjct: 1   MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60

Query: 61  LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
           LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
Sbjct: 61  LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120

Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
           SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180

Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
           RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240

Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
           DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300

Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPEPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL 360
           VLTDFGLCKEGIAISDTTTTFCGTPEPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL
Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPEPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL 360

Query: 361 EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTA 420
           EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTA
Sbjct: 361 EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTA 420

Query: 421 FTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL 464
           FTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL
Sbjct: 421 FTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL 464


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  929 bits (2401), Expect = 0.0
 Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%)

Query: 1   MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
           MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
Sbjct: 1   MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60

Query: 61  LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
           LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
Sbjct: 61  LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120

Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
           SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180

Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
           RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240

Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
           DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300

Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPE--------------------------------PP 328
           VLTDFGLCKEGIAISDTTTTFCGTPE                                PP
Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP 360

Query: 329 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 388
           FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE
Sbjct: 361 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420

Query: 389 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 448
           SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD
Sbjct: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 480

Query: 449 AFVGFSYAPPSEDLFL 464
           AFVGFSYAPPSEDLFL
Sbjct: 481 AFVGFSYAPPSEDLFL 496


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  929 bits (2401), Expect = 0.0
 Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%)

Query: 1   MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
           MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
Sbjct: 1   MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60

Query: 61  LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
           LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
Sbjct: 61  LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120

Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
           SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180

Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
           RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240

Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
           DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300

Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPE--------------------------------PP 328
           VLTDFGLCKEGIAISDTTTTFCGTPE                                PP
Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP 360

Query: 329 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 388
           FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE
Sbjct: 361 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420

Query: 389 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 448
           SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD
Sbjct: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 480

Query: 449 AFVGFSYAPPSEDLFL 464
           AFVGFSYAPPSEDLFL
Sbjct: 481 AFVGFSYAPPSEDLFL 496


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  497 bits (1280), Expect = e-141
 Identities = 256/430 (59%), Positives = 308/430 (71%), Gaps = 45/430 (10%)

Query: 67  AMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH-- 124
           A  L  P  R F  N DP F+KQRR GLN+FIQ +        HP+V++ L++  P+   
Sbjct: 103 ANILTKPDPRTFWTNDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPE 162

Query: 125 --QSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRK 182
              ++PS            S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K
Sbjct: 163 LMNANPSPPP---------SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 213

Query: 183 LDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDF 242
            +  FYAVKVLQKK +L +KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD+
Sbjct: 214 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 273

Query: 243 VNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVL 302
           +NGGELF+HLQRER F E RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VL
Sbjct: 274 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVL 333

Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330
           TDFGLCKE I  + TT+TFCGTPE                                PPFY
Sbjct: 334 TDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY 393

Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESL 390
            R+ AEMYDNIL+KPL L+P ++ +A  +LE LL+KDR  RLGAK+DF+EI++H FF  +
Sbjct: 394 SRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLI 453

Query: 391 SWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAF 450
           +W DL+ KKI PPFNPNV+GP+D+R+FD  FTEE VP S+  S D  +V ASV EA +AF
Sbjct: 454 NWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAF 513

Query: 451 VGFSYAPPSE 460
           +GFSYAPP++
Sbjct: 514 LGFSYAPPTD 523


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  487 bits (1254), Expect = e-138
 Identities = 248/411 (60%), Positives = 300/411 (72%), Gaps = 45/411 (10%)

Query: 86  FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
           F+KQRR GLN+FIQ +        HP+V++ L++  P+      ++PS            
Sbjct: 27  FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 77

Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
           S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K +  FYAVKVLQKK +L +
Sbjct: 78  SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 137

Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
           KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E 
Sbjct: 138 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 197

Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
           RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I  + TT+TF
Sbjct: 198 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 257

Query: 322 CGTPE--------------------------------PPFYCRDVAEMYDNILHKPLSLR 349
           CGTPE                                PPFY R+ AEMYDNIL+KPL L+
Sbjct: 258 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 317

Query: 350 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 409
           P ++ +A  +LE LL+KDR  RLGAK+DF+EI++H FF  ++W DL+ KKI PPFNPNV+
Sbjct: 318 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 377

Query: 410 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 460
           GP+D+R+FD  FTEE VP S+  S D  +V ASV EA +AF+GFSYAPP++
Sbjct: 378 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 428


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  487 bits (1254), Expect = e-138
 Identities = 248/411 (60%), Positives = 300/411 (72%), Gaps = 45/411 (10%)

Query: 86  FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
           F+KQRR GLN+FIQ +        HP+V++ L++  P+      ++PS            
Sbjct: 41  FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 91

Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
           S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K +  FYAVKVLQKK +L +
Sbjct: 92  SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 151

Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
           KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E 
Sbjct: 152 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 211

Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
           RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I  + TT+TF
Sbjct: 212 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 271

Query: 322 CGTPE--------------------------------PPFYCRDVAEMYDNILHKPLSLR 349
           CGTPE                                PPFY R+ AEMYDNIL+KPL L+
Sbjct: 272 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 331

Query: 350 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 409
           P ++ +A  +LE LL+KDR  RLGAK+DF+EI++H FF  ++W DL+ KKI PPFNPNV+
Sbjct: 332 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 391

Query: 410 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 460
           GP+D+R+FD  FTEE VP S+  S D  +V ASV EA +AF+GFSYAPP++
Sbjct: 392 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 442


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  487 bits (1254), Expect = e-138
 Identities = 248/411 (60%), Positives = 300/411 (72%), Gaps = 45/411 (10%)

Query: 86  FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
           F+KQRR GLN+FIQ +        HP+V++ L++  P+      ++PS            
Sbjct: 55  FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 105

Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
           S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K +  FYAVKVLQKK +L +
Sbjct: 106 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 165

Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
           KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E 
Sbjct: 166 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 225

Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
           RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I  + TT+TF
Sbjct: 226 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 285

Query: 322 CGTPE--------------------------------PPFYCRDVAEMYDNILHKPLSLR 349
           CGTPE                                PPFY R+ AEMYDNIL+KPL L+
Sbjct: 286 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 345

Query: 350 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 409
           P ++ +A  +LE LL+KDR  RLGAK+DF+EI++H FF  ++W DL+ KKI PPFNPNV+
Sbjct: 346 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 405

Query: 410 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 460
           GP+D+R+FD  FTEE VP S+  S D  +V ASV EA +AF+GFSYAPP++
Sbjct: 406 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 456


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  434 bits (1117), Expect = e-122
 Identities = 217/349 (62%), Positives = 259/349 (74%), Gaps = 35/349 (10%)

Query: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
           NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ 
Sbjct: 19  NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 78

Query: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
           HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 79  HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 138

Query: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
           YAAE+ASA+GYLHS+ I+YRDLKPENILLD  GHVVLTDFGLCKEG+   DTT+TFCGTP
Sbjct: 139 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 198

Query: 326 E--------------------------------PPFYCRDVAEMYDNILHKPLSLRPGVS 353
           E                                PPFY +DV++MY+NILH+PL +  G +
Sbjct: 199 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 258

Query: 354 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 413
           + A  +L+ LL KD++ RLG+K DFLEI+NH FF  ++W DL  K++ PPFNPNV GP D
Sbjct: 259 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 318

Query: 414 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 462
           +++FD  FT+E V  S+  + D     AS   A  AF+GFSYAP  +D+
Sbjct: 319 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 364


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  434 bits (1117), Expect = e-122
 Identities = 217/349 (62%), Positives = 259/349 (74%), Gaps = 35/349 (10%)

Query: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
           NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ 
Sbjct: 79  NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 138

Query: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
           HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 139 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 198

Query: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
           YAAE+ASA+GYLHS+ I+YRDLKPENILLD  GHVVLTDFGLCKEG+   DTT+TFCGTP
Sbjct: 199 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 258

Query: 326 E--------------------------------PPFYCRDVAEMYDNILHKPLSLRPGVS 353
           E                                PPFY +DV++MY+NILH+PL +  G +
Sbjct: 259 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 318

Query: 354 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 413
           + A  +L+ LL KD++ RLG+K DFLEI+NH FF  ++W DL  K++ PPFNPNV GP D
Sbjct: 319 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 378

Query: 414 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 462
           +++FD  FT+E V  S+  + D     AS   A  AF+GFSYAP  +D+
Sbjct: 379 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 424


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  275 bits (703), Expect = 6e-74
 Identities = 162/401 (40%), Positives = 219/401 (54%), Gaps = 58/401 (14%)

Query: 87  IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137
           +K  R   N FI   +++  +     +     +D+P+ + + +E            E   
Sbjct: 62  MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116

Query: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190
                TSQ  N+G      S   H + T  DFD+LK++GKG+FGKV+L + K  GK+YA+
Sbjct: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176

Query: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250
           K+L+K++++ + E  H + E  VL KN +HPFL  L YSFQT ++L FV+++VNGGELFF
Sbjct: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235

Query: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310
           HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD  GH+ +TDFGLCKE
Sbjct: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295

Query: 311 GIAISDTTTTFCGTPE--------------------------------PPFYCRDVAEMY 338
           GI  + T  TFCGTPE                                 PFY +D  +++
Sbjct: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355

Query: 339 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 397
           + IL + +     +S  A S+L  LL KD   RL G  +D  EI  H FF  ++W D+  
Sbjct: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415

Query: 398 KKIPPPFNPNVAGPDDIRNFDTAFTEETV---PYSVCVSSD 435
           KK+ PPF P V    D R FD  FT +T+   P   C  SD
Sbjct: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  275 bits (702), Expect = 8e-74
 Identities = 164/419 (39%), Positives = 225/419 (53%), Gaps = 55/419 (13%)

Query: 87  IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137
           +K  R   N FI   +++  +     +     +D+P+ + + +E            E   
Sbjct: 62  MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116

Query: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190
                TSQ  N+G      S   H + T  DFD+LK++GKG+FGKV+L + K  GK+YA+
Sbjct: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176

Query: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250
           K+L+K++++ + E  H + E  VL KN +HPFL  L YSFQT ++L FV+++VNGGELFF
Sbjct: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235

Query: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310
           HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD  GH+ +TDFGLCKE
Sbjct: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295

Query: 311 GIAISDTTTTFCGTPE--------------------------------PPFYCRDVAEMY 338
           GI  + T  TFCGTPE                                 PFY +D  +++
Sbjct: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355

Query: 339 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 397
           + IL + +     +S  A S+L  LL KD   RL G  +D  EI  H FF  ++W D+  
Sbjct: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415

Query: 398 KKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYA 456
           KK+ PPF P V    D R FD  FT +T+  +     D   ++    E    F  FSY+
Sbjct: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYS 474


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  268 bits (684), Expect = 1e-71
 Identities = 155/381 (40%), Positives = 219/381 (57%), Gaps = 41/381 (10%)

Query: 113 VRAFLQMDSPKHQSDPSED--EDERSSQKLHSTSQNINLGPSGNPHAKPT--DFDFLKVI 168
           +RA   + +   Q  P ED  + +  S    ST++ + +  S    AK T  DFD+LK++
Sbjct: 100 MRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVS-KARAKVTMNDFDYLKLL 158

Query: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
           GKG+FGKV+L + K  G++YA+K+L+K++++ + E  H + E  VL +N +HPFL  L Y
Sbjct: 159 GKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKY 217

Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
           +FQT ++L FV+++ NGGELFFHL RER F E RARFY AEI SAL YLHS  +VYRD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277

Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE---------------------- 326
            EN++LD  GH+ +TDFGLCKEGI+   T  TFCGTPE                      
Sbjct: 278 LENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG 337

Query: 327 ----------PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAK 375
                      PFY +D   +++ IL + +     +S  A S+L  LL+KD + RL G  
Sbjct: 338 VVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGP 397

Query: 376 EDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSD 435
            D  E+  H FF S++W D+VQKK+ PPF P V    D R FD  FT +++  ++     
Sbjct: 398 SDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI--TITPPDR 455

Query: 436 YSIVNASVLEADDAFVGFSYA 456
           Y  +    L+    F  FSY+
Sbjct: 456 YDSLGLLELDQRTHFPQFSYS 476


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  255 bits (651), Expect = 7e-68
 Identities = 143/337 (42%), Positives = 193/337 (57%), Gaps = 41/337 (12%)

Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183
           + E+E    +  S S N          AKP       +F++LK++GKG+FGKV+L K K 
Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171

Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243
            G++YA+K+L+K++++ + E  H + E  VL +N +HPFL  L YSFQT ++L FV+++ 
Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230

Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302
           NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD  GH+ +
Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290

Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330
           TDFGLCKEGI    T  TFCGTPE                                 PFY
Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350

Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 389
            +D  ++++ IL + +     +   A S+L  LL+KD + RL G  ED  EI  H FF  
Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410

Query: 390 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 426
           + W  + +KK+ PPF P V    D R FD  FT + +
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  255 bits (651), Expect = 7e-68
 Identities = 143/337 (42%), Positives = 193/337 (57%), Gaps = 41/337 (12%)

Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183
           + E+E    +  S S N          AKP       +F++LK++GKG+FGKV+L K K 
Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171

Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243
            G++YA+K+L+K++++ + E  H + E  VL +N +HPFL  L YSFQT ++L FV+++ 
Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230

Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302
           NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD  GH+ +
Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290

Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330
           TDFGLCKEGI    T  TFCGTPE                                 PFY
Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350

Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 389
            +D  ++++ IL + +     +   A S+L  LL+KD + RL G  ED  EI  H FF  
Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410

Query: 390 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 426
           + W  + +KK+ PPF P V    D R FD  FT + +
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  255 bits (651), Expect = 7e-68
 Identities = 143/337 (42%), Positives = 193/337 (57%), Gaps = 41/337 (12%)

Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183
           + E+E    +  S S N          AKP       +F++LK++GKG+FGKV+L K K 
Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171

Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243
            G++YA+K+L+K++++ + E  H + E  VL +N +HPFL  L YSFQT ++L FV+++ 
Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230

Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302
           NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD  GH+ +
Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290

Query: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330
           TDFGLCKEGI    T  TFCGTPE                                 PFY
Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350

Query: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 389
            +D  ++++ IL + +     +   A S+L  LL+KD + RL G  ED  EI  H FF  
Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410

Query: 390 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 426
           + W  + +KK+ PPF P V    D R FD  FT + +
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447


>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score =  249 bits (636), Expect = 4e-66
 Identities = 148/396 (37%), Positives = 209/396 (52%), Gaps = 63/396 (15%)

Query: 117 LQMDSPKHQSD------PSEDEDERSSQKLHSTSQNINLGPSGNPHAKP--TDFDFLKVI 168
           + MD     SD      P       S  ++    + +N   SG   +     DFD L+VI
Sbjct: 201 MPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260

Query: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
           G+GS+ KVLL + K   + YA+KV++K++V + ++   +  E++V  +   HPFLVGLH 
Sbjct: 261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS 320

Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
            FQT  +L+FV+++VNGG+L FH+QR+R  PE  ARFY+AEI+ AL YLH   I+YRDLK
Sbjct: 321 CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 380

Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP----------------------- 325
            +N+LLDS GH+ LTD+G+CKEG+   DTT+TFCGTP                       
Sbjct: 381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 440

Query: 326 ---------EPPFYCRDVAEMYDN------------ILHKPLSLRPGVSLTAWSILEELL 364
                      PF   D+    DN            IL K + +   +S+ A S+L+  L
Sbjct: 441 VLMFEMMAGRSPF---DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 497

Query: 365 EKDRQNRLGA--KEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFT 422
            KD + RLG   +  F +IQ HPFF ++ W  + QK++ PPF PN++G   + NFD+ FT
Sbjct: 498 NKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFT 557

Query: 423 EETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
            E V  +     D  IV          F GF Y  P
Sbjct: 558 NEPVQLT---PDDDDIVRKI---DQSEFEGFEYINP 587


>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
           sapiens]
          Length = 482

 Score =  244 bits (624), Expect = 9e-65
 Identities = 147/360 (40%), Positives = 207/360 (57%), Gaps = 50/360 (13%)

Query: 138 QKLHSTSQNINLGPSG-NPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVL 193
           +++  T  ++N+GP    PH     F+ L+V+GKG +GKV   ++      GK YA+KVL
Sbjct: 46  EEVELTETSVNVGPERIGPHC----FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVL 101

Query: 194 QK-KIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHL 252
           +K KIV N K+  H  AERN+L ++VKHPF+V L Y+FQT  KLY +L+ ++GGELF HL
Sbjct: 102 RKAKIVRNAKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHL 160

Query: 253 QRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGI 312
           +RE  F E  A FY AEI  ALG+LHS  I+YRDLKPENI+L S GH+ LTDFGLCKE I
Sbjct: 161 EREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI 220

Query: 313 AISDTTTTFCGTPE--------------------------------PPFYCRDVAEMYDN 340
                T TFCGT E                                PPF   +  +  D 
Sbjct: 221 HEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDK 280

Query: 341 ILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQKK 399
           I+   L+L P ++  A  ++++ L+++   R+ G   D  ++Q HPFF  ++W DL+  +
Sbjct: 281 IIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWR 340

Query: 400 IPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 459
           + PPF P +   +D+  FDT FT +T P     S D + ++ S   A+ AF+GF+Y  PS
Sbjct: 341 VDPPFRPCLQSEEDVSQFDTRFTRQT-PVD---SPDDTALSES---ANQAFLGFTYVAPS 393


>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
           sapiens]
          Length = 525

 Score =  243 bits (619), Expect = 3e-64
 Identities = 147/359 (40%), Positives = 206/359 (57%), Gaps = 48/359 (13%)

Query: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVLQ 194
           +K   +  ++N GP      +P  F+ L+V+GKG +GKV   ++      GK +A+KVL+
Sbjct: 70  EKFEISETSVNRGPE---KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK 126

Query: 195 KK-IVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ 253
           K  IV N K+  H  AERN+L + VKHPF+V L Y+FQT  KLY +L++++GGELF  L+
Sbjct: 127 KAMIVRNAKDTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLE 185

Query: 254 RERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIA 313
           RE  F E  A FY AEI+ ALG+LH   I+YRDLKPENI+L+  GHV LTDFGLCKE I 
Sbjct: 186 REGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIH 245

Query: 314 ISDTTTTFCGTPE--------------------------------PPFYCRDVAEMYDNI 341
               T TFCGT E                                PPF   +  +  D I
Sbjct: 246 DGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKI 305

Query: 342 LHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPFFESLSWADLVQKKI 400
           L   L+L P ++  A  +L++LL+++  +RLGA   D  E+Q HPFF  ++W +L+ +K+
Sbjct: 306 LKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKV 365

Query: 401 PPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 459
            PPF P +   +D+  FD+ FT +T P     S D S ++ S   A+  F+GF+Y  PS
Sbjct: 366 EPPFKPLLQSEEDVSQFDSKFTRQT-PVD---SPDDSTLSES---ANQVFLGFTYVAPS 417


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  240 bits (612), Expect = 2e-63
 Identities = 133/330 (40%), Positives = 188/330 (56%), Gaps = 41/330 (12%)

Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
           +F+F+KV+GKGSFGKV+LA+ K   + YAVKVL+K ++L   +    M E+ +L    KH
Sbjct: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466

Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
           P+L  L+  FQT ++L+FV+++VNGG+L F +QR R F E R+RFYAAE+ SAL +LH  
Sbjct: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526

Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325
            ++YRDLK +NILLD+ GH  L DFG+CKEGI    TTTTFCGTP               
Sbjct: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586

Query: 326 -----------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 368
                            +PPF   +  +++++ILH  +     +S  A SIL+  + K+ 
Sbjct: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646

Query: 369 QNRLG---AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 425
             RLG   ++     I+ HPFF+ + W  L QKKI PPF P +    D+ NFD  FT E 
Sbjct: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706

Query: 426 VPYSVCVSSDYSIVNASVLEADDAFVGFSY 455
              ++   +    +N       + F GFSY
Sbjct: 707 PVLTLVDEAIVKQIN------QEEFKGFSY 730


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  233 bits (593), Expect = 4e-61
 Identities = 133/355 (37%), Positives = 189/355 (53%), Gaps = 40/355 (11%)

Query: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKI 197
           Q   S+ +   +G + +      +F+F++V+GKGSFGKV+LA+ K  G  YAVKVL+K +
Sbjct: 331 QGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDV 390

Query: 198 VLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERS 257
           +L   + +  M E+ +L     HPFL  L   FQT ++L+FV++FVNGG+L FH+Q+ R 
Sbjct: 391 ILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR 450

Query: 258 FPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDT 317
           F E RARFYAAEI SAL +LH   I+YRDLK +N+LLD  GH  L DFG+CKEGI    T
Sbjct: 451 FDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVT 510

Query: 318 TTTFCGTPE--------------------------------PPFYCRDVAEMYDNILHKP 345
           T TFCGTP+                                 PF   +  ++++ IL+  
Sbjct: 511 TATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDE 570

Query: 346 LSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLE--IQNHPFFESLSWADLVQKKIPPP 403
           +     +   A  IL+  + K+   RLG+     E  I  HPFF+ + WA L  ++I PP
Sbjct: 571 VVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPP 630

Query: 404 FNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
           F P +   +D+ NFD  F +E    +        ++N       D F  FSY  P
Sbjct: 631 FRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMIN------QDEFRNFSYVSP 679


>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  233 bits (593), Expect = 4e-61
 Identities = 132/339 (38%), Positives = 191/339 (56%), Gaps = 47/339 (13%)

Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
           DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++   +  E++V  +   +
Sbjct: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127

Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
           PFLVGLH  FQTT +L+ V+++VNGG+L FH+QR+R  PE  ARFYAAEI  AL +LH  
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187

Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325
            I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+   DTT+TFCGTP               
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247

Query: 326 -----------------EPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 361
                              PF    D  +M      +  IL KP+ +   +S+ A  +L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307

Query: 362 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 419
             L KD + RLG +    F +I++H FF S+ W  L +K+  PPF P +     + NFDT
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367

Query: 420 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
            FT E  P  +    + +I      E    F GF Y  P
Sbjct: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400


>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  233 bits (593), Expect = 4e-61
 Identities = 132/339 (38%), Positives = 191/339 (56%), Gaps = 47/339 (13%)

Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
           DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++   +  E++V  +   +
Sbjct: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127

Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
           PFLVGLH  FQTT +L+ V+++VNGG+L FH+QR+R  PE  ARFYAAEI  AL +LH  
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187

Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325
            I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+   DTT+TFCGTP               
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247

Query: 326 -----------------EPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 361
                              PF    D  +M      +  IL KP+ +   +S+ A  +L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307

Query: 362 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 419
             L KD + RLG +    F +I++H FF S+ W  L +K+  PPF P +     + NFDT
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367

Query: 420 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
            FT E  P  +    + +I      E    F GF Y  P
Sbjct: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400


>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
          Length = 592

 Score =  233 bits (593), Expect = 4e-61
 Identities = 132/339 (38%), Positives = 191/339 (56%), Gaps = 47/339 (13%)

Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
           DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++   +  E++V  +   +
Sbjct: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310

Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
           PFLVGLH  FQTT +L+ V+++VNGG+L FH+QR+R  PE  ARFYAAEI  AL +LH  
Sbjct: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370

Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325
            I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+   DTT+TFCGTP               
Sbjct: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430

Query: 326 -----------------EPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 361
                              PF    D  +M      +  IL KP+ +   +S+ A  +L+
Sbjct: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490

Query: 362 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 419
             L KD + RLG +    F +I++H FF S+ W  L +K+  PPF P +     + NFDT
Sbjct: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550

Query: 420 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
            FT E  P  +    + +I      E    F GF Y  P
Sbjct: 551 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 583


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  231 bits (589), Expect = 1e-60
 Identities = 140/391 (35%), Positives = 203/391 (51%), Gaps = 56/391 (14%)

Query: 117 LQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKP----------------T 160
           L  +  ++ + P  + DE  + +L    +   LGP+GN    P                T
Sbjct: 278 LNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT 337

Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
           DF+FL V+GKGSFGKV+LA RK   + YA+K+L+K +V+   + +  M E+ VL    K 
Sbjct: 338 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 397

Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
           PFL  LH  FQT ++LYFV+++VNGG+L +H+Q+   F E +A FYAAEI+  L +LH  
Sbjct: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457

Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP--------------- 325
            I+YRDLK +N++LDS GH+ + DFG+CKE +    TT TFCGTP               
Sbjct: 458 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK 517

Query: 326 -----------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 368
                            +PPF   D  E++ +I+   +S    +S  A SI + L+ K  
Sbjct: 518 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP 577

Query: 369 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVP 427
             RLG   E   +++ H FF  + W  L  ++I PPF P V G     NFD  FT     
Sbjct: 578 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCG-KGAENFDKFFTRG--- 633

Query: 428 YSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
               ++    +V A++ ++D  F GFSY  P
Sbjct: 634 -QPVLTPPDQLVIANIDQSD--FEGFSYVNP 661


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  221 bits (563), Expect = 1e-57
 Identities = 129/334 (38%), Positives = 181/334 (54%), Gaps = 39/334 (11%)

Query: 158 KPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKN 217
           K TDF+FL V+GKGSFGKV+L++RK   + YAVK+L+K +V+   + +  M E+ VL   
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397

Query: 218 VKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYL 277
            K PFL  LH  FQT ++LYFV+++VNGG+L +H+Q+   F E  A FYAAEIA  L +L
Sbjct: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457

Query: 278 HSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP------------ 325
            S  I+YRDLK +N++LDS GH+ + DFG+CKE I    TT TFCGTP            
Sbjct: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517

Query: 326 --------------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLE 365
                               + PF   D  E++ +I+   ++    +S  A +I + L+ 
Sbjct: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577

Query: 366 KDRQNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 424
           K    RLG   E   +I+ H FF  + W  L +K+I PP+ P      D  NFD  FT +
Sbjct: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQ 637

Query: 425 TVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 458
             P  +  +    I+N       + F GFSY  P
Sbjct: 638 --PVELTPTDKLFIMNLD----QNEFAGFSYTNP 665


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  221 bits (562), Expect = 1e-57
 Identities = 137/340 (40%), Positives = 182/340 (53%), Gaps = 42/340 (12%)

Query: 122 PKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK- 180
           P   S P  D DE   +++  T        +G+  A P+ F+ LKV+G+GSFGKV L + 
Sbjct: 35  PGPGSGPQRDSDEGVLKEISITHHV----KAGSEKADPSHFELLKVLGQGSFGKVFLVRK 90

Query: 181 --RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYF 238
             R   G  YA+KVL KK  L  +++     ER++L  +V HPF+V LHY+FQT  KLY 
Sbjct: 91  VTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILA-DVNHPFVVKLHYAFQTEGKLYL 148

Query: 239 VLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVG 298
           +LDF+ GG+LF  L +E  F E   +FY AE+A  L +LHS+ I+YRDLKPENILLD  G
Sbjct: 149 ILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEG 208

Query: 299 HVVLTDFGLCKEGIAISDTTTTFCGTPE-------------------------------- 326
           H+ LTDFGL KE I       +FCGT E                                
Sbjct: 209 HIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGS 268

Query: 327 PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EIQNHP 385
            PF  +D  E    IL   L +   +S  A S+L  L +++  NRLG+  D   EI+ H 
Sbjct: 269 LPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV 328

Query: 386 FFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 425
           F+ ++ W  L +++I PPF P VA PDD   FDT FT  T
Sbjct: 329 FYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRT 368



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 52/163 (31%), Positives = 80/163 (49%), Gaps = 11/163 (6%)

Query: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
           + IG GS+ +      K     YAVKV+ K        ++    E  +LL+  +HP ++ 
Sbjct: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 483

Query: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
           L   +   + +Y V + + GGEL   + R++ F E  A F    I   + YLHS  +V+R
Sbjct: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543

Query: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGT 324
           DLKP NIL +D  G+   + + DFG  K+  A +    T C T
Sbjct: 544 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYT 586


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
           sapiens]
          Length = 740

 Score =  218 bits (555), Expect = 9e-57
 Identities = 143/380 (37%), Positives = 197/380 (51%), Gaps = 52/380 (13%)

Query: 119 MDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLL 178
           MD P  + + +   +E S +++  T         G+  A P+ F+ LKV+G+GSFGKV L
Sbjct: 29  MDEPMGEEEINPQTEEVSIKEIAITHHV----KEGHEKADPSQFELLKVLGQGSFGKVFL 84

Query: 179 AKRKLDG----KFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTE 234
            K K+ G    + YA+KVL KK  L  +++     ER++L++ V HPF+V LHY+FQT  
Sbjct: 85  VK-KISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDILVE-VNHPFIVKLHYAFQTEG 141

Query: 235 KLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILL 294
           KLY +LDF+ GG+LF  L +E  F E   +FY AE+A AL +LHS+ I+YRDLKPENILL
Sbjct: 142 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL 201

Query: 295 DSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE---------------------------- 326
           D  GH+ LTDFGL KE I       +FCGT E                            
Sbjct: 202 DEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEM 261

Query: 327 ----PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EI 381
                PF  +D  E    IL   L +   +S  A S+L  L +++  NRLGA  D + EI
Sbjct: 262 LTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEI 321

Query: 382 QNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNA 441
           + H FF ++ W  L +++I PPF P    P+D   FD  FT +T   S  +         
Sbjct: 322 KRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPS------ 375

Query: 442 SVLEADDAFVGFSYAPPSED 461
               A   F GFS+   + D
Sbjct: 376 --ANAHQLFRGFSFVAITSD 393



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 48/161 (29%), Positives = 77/161 (47%), Gaps = 11/161 (6%)

Query: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLH 227
           IG GS+        K     +AVK++ K        ++    E  +LL+  +HP ++ L 
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480

Query: 228 YSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDL 287
             +   + +Y V + + GGEL   + R++ F E  A      I   + YLH+  +V+RDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540

Query: 288 KPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGT 324
           KP NIL +D  G+   + + DFG  K+  A +    T C T
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYT 581


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform a [Homo sapiens]
          Length = 735

 Score =  218 bits (554), Expect = 1e-56
 Identities = 130/310 (41%), Positives = 172/310 (55%), Gaps = 38/310 (12%)

Query: 152 SGNPHAKPTDFDFLKVIGKGSFGKVLLAK---RKLDGKFYAVKVLQKKIVLNRKEQKHIM 208
           +G+  A P+ F+ LKV+G+GSFGKV L +   R   G  YA+KVL KK  L  +++    
Sbjct: 52  AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 110

Query: 209 AERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAA 268
            ER++L  +V HPF+V LHY+FQT  KLY +LDF+ GG+LF  L +E  F E   +FY A
Sbjct: 111 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 169

Query: 269 EIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE-- 326
           E+A  L +LHS+ I+YRDLKPENILLD  GH+ LTDFGL KE I       +FCGT E  
Sbjct: 170 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 229

Query: 327 ------------------------------PPFYCRDVAEMYDNILHKPLSLRPGVSLTA 356
                                          PF  +D  E    IL   L +   +S  A
Sbjct: 230 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 289

Query: 357 WSILEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIR 415
            S+L  L +++  NRLG+  D   EI+ H F+ ++ W  L +++I PPF P VA PDD  
Sbjct: 290 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 349

Query: 416 NFDTAFTEET 425
            FDT FT  T
Sbjct: 350 YFDTEFTSRT 359



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 52/163 (31%), Positives = 80/163 (49%), Gaps = 11/163 (6%)

Query: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
           + IG GS+ +      K     YAVKV+ K        ++    E  +LL+  +HP ++ 
Sbjct: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 474

Query: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
           L   +   + +Y V + + GGEL   + R++ F E  A F    I   + YLHS  +V+R
Sbjct: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534

Query: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGT 324
           DLKP NIL +D  G+   + + DFG  K+  A +    T C T
Sbjct: 535 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYT 577


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  217 bits (553), Expect = 2e-56
 Identities = 141/383 (36%), Positives = 196/383 (51%), Gaps = 50/383 (13%)

Query: 112 DVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKG 171
           +V     +D P  + +     DE   +++  T         G   A P  F+ LKV+G+G
Sbjct: 27  EVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHV----KEGYEKADPAQFELLKVLGQG 82

Query: 172 SFGKVLLAKRKLD---GKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
           SFGKV L ++K     G+ YA+KVL KK  L  +++     ER++L++ V HPF+V LHY
Sbjct: 83  SFGKVFLVRKKTGPDAGQLYAMKVL-KKASLKVRDRVRTKMERDILVE-VNHPFIVKLHY 140

Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
           +FQT  KLY +LDF+ GG++F  L +E  F E   +FY AE+A AL +LH + IVYRDLK
Sbjct: 141 AFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLK 200

Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPE---------------------- 326
           PENILLD +GH+ LTDFGL KE +       +FCGT E                      
Sbjct: 201 PENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYG 260

Query: 327 ----------PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKE 376
                      PF  +D  E  + IL   L +   +S  A S+L  L +++  NRLG+ E
Sbjct: 261 VLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS-E 319

Query: 377 DFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDY 436
              EI+ H FF ++ W  L ++++ PPF P    PDD   FD  FT +T         D 
Sbjct: 320 GVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKT-------PKDS 372

Query: 437 SIVNASVLEADDAFVGFSYAPPS 459
             + AS   A   F GFS+   S
Sbjct: 373 PGLPASA-NAHQLFKGFSFVATS 394



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 42/153 (27%), Positives = 70/153 (45%), Gaps = 11/153 (7%)

Query: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221
           ++  + IG GS+              +AVK++ K        ++    E  +L++  +HP
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKS-------KRDPSEEIEILMRYGQHP 478

Query: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281
            ++ L   F     +Y V D + GGEL   + +++ F E  A      I+  + YLH   
Sbjct: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538

Query: 282 IVYRDLKPENILL----DSVGHVVLTDFGLCKE 310
           +V+RDLKP NIL      S   + + DFG  K+
Sbjct: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQ 571


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  214 bits (545), Expect = 1e-55
 Identities = 130/352 (36%), Positives = 186/352 (52%), Gaps = 54/352 (15%)

Query: 111 PDVRAFLQMDSPK---HQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKV 167
           P  ++  + D+P+     S   E ED RS Q+     Q               DF    V
Sbjct: 618 PKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQ---------------DFRCCAV 662

Query: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVL--LKNVKHPFLVG 225
           +G+G FGKVLLA+ K   + +A+K L+K  ++ R E   +M E+ +   + +V+HPFLV 
Sbjct: 663 LGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 722

Query: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
           L   FQT E + FV+++  GG+L  H+  +  F E RA FYAA +   L YLH  KIVYR
Sbjct: 723 LFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYR 781

Query: 286 DLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP-------------------- 325
           DLK +N+LLD+ G V + DFGLCKEG+   D T+TFCGTP                    
Sbjct: 782 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWW 841

Query: 326 ------------EPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLG 373
                       E PF   D  E++D+I++  +     +S  A SI+  LL ++ + RLG
Sbjct: 842 GLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLG 901

Query: 374 AKE-DFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 424
           A E D  +++ HPFF  + W+ L+ KK+ PPF P + G +D+ NFD  FT E
Sbjct: 902 ASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSE 953


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,946,361
Number of Sequences: 37866
Number of extensions: 859285
Number of successful extensions: 3895
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 709
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 2203
Number of HSP's gapped (non-prelim): 1086
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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