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Search of human proteins with 31543140
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31543140 Usher syndrome 1C binding protein 1 [Homo sapiens]
(703 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31543140 Usher syndrome 1C binding protein 1 [Homo sapiens] 1377 0.0
gi|146229340 mutated in colorectal cancers isoform 1 [Homo sapiens] 161 2e-39
gi|4505129 mutated in colorectal cancers isoform 2 [Homo sapiens] 161 2e-39
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 62 2e-09
gi|21735548 centrosomal protein 2 [Homo sapiens] 55 2e-07
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 55 2e-07
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 55 2e-07
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 55 2e-07
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 55 2e-07
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 54 4e-07
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 54 5e-07
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 52 1e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 50 7e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 50 7e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 50 7e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 50 7e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 50 7e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 50 7e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 50 7e-06
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 50 7e-06
gi|221219026 pleckstrin homology-like domain, family B, member 1... 48 3e-05
gi|32484977 angiomotin like 2 [Homo sapiens] 48 3e-05
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 48 4e-05
gi|110611218 ribosome binding protein 1 [Homo sapiens] 47 6e-05
gi|110611220 ribosome binding protein 1 [Homo sapiens] 47 6e-05
gi|221219024 pleckstrin homology-like domain, family B, member 1... 44 4e-04
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 44 4e-04
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 44 4e-04
gi|18644728 nucleolar protein family 6 alpha isoform [Homo sapiens] 43 9e-04
gi|16262452 cingulin [Homo sapiens] 42 0.003
>gi|31543140 Usher syndrome 1C binding protein 1 [Homo sapiens]
Length = 703
Score = 1377 bits (3564), Expect = 0.0
Identities = 703/703 (100%), Positives = 703/703 (100%)
Query: 1 MSARATRPRSRRGRHAPPGELDPVAESSEEVEAASGSSKPSFAPPPVSSGLEQLGPMEEV 60
MSARATRPRSRRGRHAPPGELDPVAESSEEVEAASGSSKPSFAPPPVSSGLEQLGPMEEV
Sbjct: 1 MSARATRPRSRRGRHAPPGELDPVAESSEEVEAASGSSKPSFAPPPVSSGLEQLGPMEEV 60
Query: 61 SGQGLGSRTDKKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQ 120
SGQGLGSRTDKKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQ
Sbjct: 61 SGQGLGSRTDKKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQ 120
Query: 121 TLQHTLSSLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAGSCQREAARLAERN 180
TLQHTLSSLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAGSCQREAARLAERN
Sbjct: 121 TLQHTLSSLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAGSCQREAARLAERN 180
Query: 181 AWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSG 240
AWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSG
Sbjct: 181 AWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSG 240
Query: 241 SGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQL 300
SGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQL
Sbjct: 241 SGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQL 300
Query: 301 RGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLL 360
RGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLL
Sbjct: 301 RGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLL 360
Query: 361 ALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQE 420
ALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQE
Sbjct: 361 ALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQE 420
Query: 421 VAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKT 480
VAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKT
Sbjct: 421 VAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKT 480
Query: 481 QIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWERAELQA 540
QIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWERAELQA
Sbjct: 481 QIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWERAELQA 540
Query: 541 GGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTR 600
GGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTR
Sbjct: 541 GGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTR 600
Query: 601 TLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRK 660
TLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRK
Sbjct: 601 TLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRK 660
Query: 661 LEQQMALMEAQQAEEVAVLEATARALGKPRPPLPPPQLGDTFL 703
LEQQMALMEAQQAEEVAVLEATARALGKPRPPLPPPQLGDTFL
Sbjct: 661 LEQQMALMEAQQAEEVAVLEATARALGKPRPPLPPPQLGDTFL 703
>gi|146229340 mutated in colorectal cancers isoform 1 [Homo sapiens]
Length = 1019
Score = 161 bits (407), Expect = 2e-39
Identities = 161/595 (27%), Positives = 261/595 (43%), Gaps = 101/595 (16%)
Query: 170 QREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLE--- 226
++E A L E N L L S+E+EL RT+A++ AIR E++ L++ V+ELQ L ++
Sbjct: 422 EKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATG 481
Query: 227 ---PCPHLSHNQAGGSGSG--------------------------SSSSEADREPWETQD 257
P S N+ +G S SS +DR ++
Sbjct: 482 PSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI 541
Query: 258 SF-----SLAHPLLRRLRSHSSTQ----ILGSLPNQPLSPEMHIMEAQMEQLRGSIEKLK 308
S S+A L L+ S+ Q L S + ++ E + E+L IE LK
Sbjct: 542 SSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLK 601
Query: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREAD-- 366
N LL+ L+ K E +SM +G+ E+ ATAL LALQYSE C EAY +LLAL E++
Sbjct: 602 SQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQS 661
Query: 367 ------------SGAGDEAPMSDL-----------QAAEKEAWRLLAQEEAAMD-----A 398
S GD++ ++ + AE A LL + + + A
Sbjct: 662 LILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVA 721
Query: 399 GAQQNP-----------QPSPEGSSVDKPTPQEVAFQLRSYVQRLQERRSLMKI--LSEP 445
G P S SS D +E +L+ Y+Q+L+ R+ +K+ L
Sbjct: 722 GCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELE 781
Query: 446 GPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRR 505
+ P+ + Q + LE + Q+L+A +E +A+L +L L+ +
Sbjct: 782 SIHIDPLSYDVKPRGDSQRL----------DLENAVLMQELMAMKEEMAELKAQLYLLEK 831
Query: 506 EKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQG 565
EK+ LEL+ + A A+++ +E L+ E E + S SSG +E
Sbjct: 832 EKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKE----- 886
Query: 566 LPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRAR 625
+ + ++ +LA E ++ R L+ ++Q L LE++ + R
Sbjct: 887 --CADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIR 944
Query: 626 RSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
QSAE DL +A+S LV A+ A +K + + +KLE QM M + +V +L+
Sbjct: 945 HQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK 999
>gi|4505129 mutated in colorectal cancers isoform 2 [Homo sapiens]
Length = 829
Score = 161 bits (407), Expect = 2e-39
Identities = 161/595 (27%), Positives = 261/595 (43%), Gaps = 101/595 (16%)
Query: 170 QREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLE--- 226
++E A L E N L L S+E+EL RT+A++ AIR E++ L++ V+ELQ L ++
Sbjct: 232 EKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATG 291
Query: 227 ---PCPHLSHNQAGGSGSG--------------------------SSSSEADREPWETQD 257
P S N+ +G S SS +DR ++
Sbjct: 292 PSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI 351
Query: 258 SF-----SLAHPLLRRLRSHSSTQ----ILGSLPNQPLSPEMHIMEAQMEQLRGSIEKLK 308
S S+A L L+ S+ Q L S + ++ E + E+L IE LK
Sbjct: 352 SSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLK 411
Query: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREAD-- 366
N LL+ L+ K E +SM +G+ E+ ATAL LALQYSE C EAY +LLAL E++
Sbjct: 412 SQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQS 471
Query: 367 ------------SGAGDEAPMSDL-----------QAAEKEAWRLLAQEEAAMD-----A 398
S GD++ ++ + AE A LL + + + A
Sbjct: 472 LILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVA 531
Query: 399 GAQQNP-----------QPSPEGSSVDKPTPQEVAFQLRSYVQRLQERRSLMKI--LSEP 445
G P S SS D +E +L+ Y+Q+L+ R+ +K+ L
Sbjct: 532 GCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELE 591
Query: 446 GPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRR 505
+ P+ + Q + LE + Q+L+A +E +A+L +L L+ +
Sbjct: 592 SIHIDPLSYDVKPRGDSQRL----------DLENAVLMQELMAMKEEMAELKAQLYLLEK 641
Query: 506 EKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQG 565
EK+ LEL+ + A A+++ +E L+ E E + S SSG +E
Sbjct: 642 EKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKE----- 696
Query: 566 LPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRAR 625
+ + ++ +LA E ++ R L+ ++Q L LE++ + R
Sbjct: 697 --CADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIR 754
Query: 626 RSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
QSAE DL +A+S LV A+ A +K + + +KLE QM M + +V +L+
Sbjct: 755 HQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK 809
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 62.0 bits (149), Expect = 2e-09
Identities = 142/624 (22%), Positives = 238/624 (38%), Gaps = 99/624 (15%)
Query: 101 AALQYKETVPPGNGAPDVFQTLQHTLSSLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSL 160
AALQ K+ + N + LQ LS LE + + PP G + L
Sbjct: 368 AALQDKKCLEEKN------EILQGKLSQLEEHLSQLQDNPPQEKGEV------------L 409
Query: 161 GKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRA----EKETLQKEVQ 216
G + ++EAA LA N L+ + E E + +A L A R EK+ L +
Sbjct: 410 GDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469
Query: 217 ELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQ 276
+LQ S+ S+ S+A E + S AH + S T
Sbjct: 470 DLQSSI--------------------SNLSQAKEE----LEQASQAHGARLTAQVASLTS 505
Query: 277 ILGSLPNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQRE 336
L +L ++ Q ++L G ++ K L+ LQ + +GL Q+ Q
Sbjct: 506 ELTTLNAT--------IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557
Query: 337 AEATALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAM 396
+ L+ +EA R A + A + EA + + AA K+ L +E+AA
Sbjct: 558 SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQL-EALEKEKAAK 616
Query: 397 DAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQRLQERRSLMKIL-SEPGPTLAPMPTV 455
QQ Q + E + + + + ++++E ++ ++ E A +
Sbjct: 617 LEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQV--- 673
Query: 456 PRAEAMVQAILGTQAGPALPRL--EKTQIQQDLVAAREALADLMLRL-QLVRREKRGLEL 512
AE +Q Q R+ EK Q+Q+ L A +E+L L + RR LE
Sbjct: 674 --AELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEE 731
Query: 513 REAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSS----GGGSSGDEEEWYQGLPA 568
++ + L L+EQ + ER EL+ A G + G + E + L
Sbjct: 732 QQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAE 791
Query: 569 VPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLD-----------LQEQLQSLRRELEQ 617
+ + E+L +E+AA R D QEQL +L+ E E+
Sbjct: 792 AMAAQHTAES-------ECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK 844
Query: 618 VAQKGRARRSQSAEL-----------NRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMA 666
Q+ + + + A + +L + H+ L A + K+ ++ +
Sbjct: 845 ARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLST 904
Query: 667 LME--AQQAEEVAVLEATARALGK 688
L E A ++EVA LE R G+
Sbjct: 905 LQEKMAATSKEVARLETLVRKAGE 928
Score = 54.7 bits (130), Expect = 3e-07
Identities = 130/615 (21%), Positives = 229/615 (37%), Gaps = 98/615 (15%)
Query: 92 AVEAHQAPEAALQYKETVPPGNG--------APDVFQTLQHTLSSLEAAAAAWRHQPPSH 143
A E Q E KE++ G A D + Q +S L+A + Q
Sbjct: 694 AQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRE 753
Query: 144 SGPMEFEGTSEGGAGSLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEA 203
+E E G + +Q G Q E L A A + E E + + A
Sbjct: 754 RKELEEERAGRKGLEARLQQLGEAH-QAETEVLRRELAEAMAAQHTAESECEQLVKEVAA 812
Query: 204 IRAEKETLQKEVQE----LQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSF 259
R E Q+E + Q+ L+ L+ E ++ E Q+
Sbjct: 813 WRERYEDSQQEEAQYGAMFQEQLMTLK-------------------EECEKARQELQE-- 851
Query: 260 SLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQ 319
A + + SHS QI E+ + A + + +++ + + L+ L
Sbjct: 852 --AKEKVAGIESHSELQISRQ------QNELAELHANLARALQQVQEKEVRAQKLADDLS 903
Query: 320 GYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQ 379
+ + S ++ + E L + E E A R L+ + + AGD P +
Sbjct: 904 TLQEKMAATSKEVARLET------LVRKAGEQQETASRELV---KEPARAGDRQP----E 950
Query: 380 AAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQRLQERRSLM 439
E++ R +AA+ A ++ Q G+ +++ + Q + +R Q+ R +
Sbjct: 951 WLEEQQGRQFCSTQAALQAMEREAEQM---GNELERLRAALMESQGQQQEERGQQEREVA 1007
Query: 440 KILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLR 499
++ E G A + A A ++ ++Q L R A L
Sbjct: 1008 RLTQERGRAQADLALEKAARAELEM----------------RLQNALNEQRVEFATLQEA 1051
Query: 500 LQLVRREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGG----S 555
L EK G + A LR L A + LE+LR +L+ A H+SG G +
Sbjct: 1052 LAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEA 1111
Query: 556 SGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRREL 615
+G E L A+ S ++ + + L + L A + L++L+ +L
Sbjct: 1112 AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQL 1171
Query: 616 EQVAQKGRARRSQSAELNRDLCKAHSALVLAFRGA---HRKQEEQ--------RRKLEQQ 664
E+ AQ+ +S A R+L AFR H K E++ R++ E++
Sbjct: 1172 EEKAQELGHSQSALASAQRELA--------AFRTKVQDHSKAEDEWKAQVARGRQEAERK 1223
Query: 665 MALMEAQQAEEVAVL 679
+L+ + + EEV++L
Sbjct: 1224 NSLISSLE-EEVSIL 1237
Score = 48.1 bits (113), Expect = 3e-05
Identities = 165/785 (21%), Positives = 290/785 (36%), Gaps = 166/785 (21%)
Query: 26 ESSEEVEAASGSSKPSFAPPPVSSGLEQLGPMEEVSGQGLG---SRTDKKMDGGSGRELA 82
ES E++ + ++ + ++ L+Q+ +EV Q L S +KM + +E+A
Sbjct: 860 ESHSELQISRQQNELAELHANLARALQQVQE-KEVRAQKLADDLSTLQEKM-AATSKEVA 917
Query: 83 SAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQTLQ-HTLSSLEAAAAAWRHQPP 141
+ K + A + KE G+ P+ + Q S +AA A +
Sbjct: 918 RLETLVRKAGEQQETASRELV--KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAE 975
Query: 142 SHSGPMEFEGTSEGGAGSLGKQ-EGAGSCQREAARLAERN----AWLRLALSSREDELVR 196
E E S G+Q E G +RE ARL + A L L ++R + +R
Sbjct: 976 QMGN--ELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR 1033
Query: 197 TQASLEAIRAEKETLQ----------------------------KEVQELQDSLLRLEPC 228
Q +L R E TLQ KE++EL+ ++ +L+
Sbjct: 1034 LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKE- 1092
Query: 229 PHLSHNQAGGSGSGSSSSEADR-EPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLS 287
+ SGSG+ S A R EP P L LR+ S L
Sbjct: 1093 QLAKKEKEHASGSGAQSEAAGRTEP---------TGPKLEALRAEVSK----------LE 1133
Query: 288 PEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREA-------EAT 340
+ + Q + L S+E + + L+ +G+ E + +LG ++ E
Sbjct: 1134 QQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELA 1193
Query: 341 ALHLALQYSEHCEEAYRVLLAL--READ------SGAGDEAPMSDLQAAEKEA------- 385
A +Q E+ ++ +A +EA+ S +E + + Q EKE
Sbjct: 1194 AFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR 1253
Query: 386 ---------------WRLLAQEEAAMDAGA-------QQNPQPSPEGSSVDKPTPQEVAF 423
RLL E A+ A A ++ Q E + + + +
Sbjct: 1254 LVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQ 1313
Query: 424 QLRSYVQRLQE---------------RRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGT 468
+L S +R +E ++L + E T A + + A+ + Q +
Sbjct: 1314 ELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAE 1373
Query: 469 QAGPALPRLEKTQ--------IQQDLVAAREALADLM-LRLQLVRREKRGLELREAA--- 516
QA E+ + ++ +L+ A+ L +L+ LR ++ +E+ +LR
Sbjct: 1374 QAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASY 1433
Query: 517 ---LRALGPAHVLLLEQLRW--ERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPG 571
L L AH LL E+ R ERA L G E++ Q L AV
Sbjct: 1434 AEQLSMLKKAHGLLAEENRGLGERANL--------GRQFLEVELDQAREKYVQELAAVRA 1485
Query: 572 GT----SGIDGGQVGRAWDPEKLAQELAASLTRTLD----LQEQLQSLRRELEQVAQKGR 623
+ + A + E + + + + L+ QE+ Q L ++EQ+ R
Sbjct: 1486 DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQR 1545
Query: 624 ARRSQSAELNRDLCKAHSA--------LVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEE 675
+ Q EL++ L + A + +G +QE QR L+ Q+ ++AQ +++
Sbjct: 1546 EQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQR--LQAQLNELQAQLSQK 1603
Query: 676 VAVLE 680
E
Sbjct: 1604 EQAAE 1608
Score = 42.4 bits (98), Expect = 0.001
Identities = 137/680 (20%), Positives = 237/680 (34%), Gaps = 104/680 (15%)
Query: 67 SRTDKKMDGGSGRELASAPEV-PHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQTLQHT 125
++ +K+ GSG + +A P P +EA +A + L+ + Q Q
Sbjct: 1095 AKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ------------CQKQQEQ 1142
Query: 126 LSSLEAAAAAWRHQPPSHSGPME-FEGTSEGGAGSLGKQEGA-GSCQREAARLAERNAWL 183
SLE + A R +E +G E A LG + A S QRE A +
Sbjct: 1143 ADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDH 1202
Query: 184 RLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGS 243
A + ++ R + E + +L++EV L +L E
Sbjct: 1203 SKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKE----------------G 1246
Query: 244 SSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGS 303
S E R + LR L++ +++ + + + +++ LR
Sbjct: 1247 ESKELKRLVMAESEKSQKLEERLRLLQAETASN------SARAAERSSALREEVQSLREE 1300
Query: 304 IEKLKCFNRLLSAVLQGYKGRCEGLSMQLG-------QREAEATALHLALQYSEHCEEAY 356
EK + + L L R E L +L Q+E + L L EH
Sbjct: 1301 AEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQL-----EHTSTQA 1355
Query: 357 RV--------LLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSP 408
V L +A+ A ++ +L+ +++ A L A+ A + P
Sbjct: 1356 LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQK 1415
Query: 409 EGSSVDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRA---------- 458
+ T Q++ + SY ++L + +L+E L + R
Sbjct: 1416 VAEQ--ERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAR 1473
Query: 459 EAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLM--LRLQLVRREKRGLELREAA 516
E VQ + +A E + Q E + +++++ +R E R+
Sbjct: 1474 EKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKL 1533
Query: 517 LRALGPAHVLLLEQLRWERAELQAGGANSSGG-----------HSSGGGSSGDEEEWYQG 565
+ V EQ + + EL A+S + GG S + +
Sbjct: 1534 TAQVEQLEVFQREQTK-QVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ 1592
Query: 566 LPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRAR 625
L + S + EK A + +LQEQL R LEQ+ ++ +
Sbjct: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL----RSLEQLQKENKEL 1648
Query: 626 RSQSAELNRDLCKAHSALVLAFRGAHRKQEEQR-RKLEQQMALMEA------QQAEEVAV 678
R+++ L +L +A G K+ EQ R L Q+ +EA QQ ++
Sbjct: 1649 RAEAERLGHELQQA---------GLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699
Query: 679 LEATARALGKPRPPLPPPQL 698
+ AL K R P PQL
Sbjct: 1700 FQVATDAL-KSREPQAKPQL 1718
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 55.1 bits (131), Expect = 2e-07
Identities = 129/584 (22%), Positives = 236/584 (40%), Gaps = 79/584 (13%)
Query: 160 LGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQ 219
L +QE G Q + L E L+ A D+L Q ++ +K LQK+V++L+
Sbjct: 960 LKEQETTGILQTQ---LQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
Query: 220 DSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILG 279
L+ + L + + ++ E ++ SL L+ + + Q
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELE-REKASLTLSLMEKEQRLLVLQEAD 1075
Query: 280 SLPNQPLSP----------EMHIMEAQMEQLRGSI-EKLKCFNRLLSAVLQGYKGRC--- 325
S+ Q LS E + AQME LR + EK F + +L+ +
Sbjct: 1076 SIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITE 1135
Query: 326 EGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEA 385
+ L L +EA+A L L L+ +E EA L A ++ + A +A ++ L +A ++A
Sbjct: 1136 QQLRASLWAQEAKAAQLQLRLRSTESQLEA---LAAEQQPGNQAQAQAQLASLYSALQQA 1192
Query: 386 WRLLAQEEAAMDAGAQQNP-----QPSPEGS-SVDKPTP-------QEVAFQLRSYVQRL 432
+ + + G P +P G+ S+ K P + VA L Q L
Sbjct: 1193 LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDL 1252
Query: 433 QERRSLMKILSEPGPTLAPMPTVPRAEA---------MVQAILGTQAGPALPRLEKTQIQ 483
+ + +L + L T AE + + + Q + ++ ++
Sbjct: 1253 WKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLE 1312
Query: 484 QDLVAAREALADLMLRL---QLVRREKRG-LELREAALRALGPAHVLLLEQLRWERAELQ 539
+L+ E +A L RL +L R E +G EL +AA L L + RA+
Sbjct: 1313 SELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQAS 1372
Query: 540 AGGANSSGGHSSGGG------SSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQE 593
A G ++ E E Q L + G++ A K QE
Sbjct: 1373 AAGILEEDLRTARSALKLKNEEVESERERAQALQ---------EQGELKVA--QGKALQE 1421
Query: 594 LAASLTRTL-DLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHSALVLAFRGAHR 652
A LT+TL + +E++++LR +++++ ++ +++ L+ DL K + + L
Sbjct: 1422 NLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDL------- 1474
Query: 653 KQEEQRRKLEQQMALME------AQQAEEVAVLEATARALGKPR 690
Q+EQ ++LE+ +++E ++ +++ V R L K R
Sbjct: 1475 -QQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDR 1517
Score = 47.0 bits (110), Expect = 6e-05
Identities = 104/543 (19%), Positives = 206/543 (37%), Gaps = 62/543 (11%)
Query: 168 SCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSL-LRLE 226
S +E L + LR L E E R + ++ + ++ Q + +E Q+ L L +
Sbjct: 460 SLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR 519
Query: 227 PCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPN-QP 285
L G S S E +S L LLR+ ++ + + + +
Sbjct: 520 ERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579
Query: 286 LSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLA 345
LS + ++ ++ LR + KL N L+ G L+ QL Q E E ++
Sbjct: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALDKVG-------LNQQLLQLEEENQSVCSR 632
Query: 346 LQYSEHCEEAYRVLLA----LREA----------------DSGAGDEAPMSDLQAAEKEA 385
++ +E A +V LA REA ++GA +A + D+Q ++E
Sbjct: 633 MEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
Query: 386 WRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQRLQERRSLMKILSEP 445
+ L++ +A Q Q QE Q + +QE+ +L++ E
Sbjct: 693 QKKLSESRHQQEAATTQLEQ-----------LHQEAKRQEEVLARAVQEKEALVR---EK 738
Query: 446 GPTLAPMPTVPR-AEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVR 504
+ V R + + + + G + L + QQ L +++Q V
Sbjct: 739 AALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
Query: 505 REKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQ 564
+ K ++ L+ EQ R + A Q A G + + E+E Q
Sbjct: 799 QAKEVIQGEVRCLKLELDTERSQAEQER-DAAARQLAQAEQEGKTALEQQKAAHEKEVNQ 857
Query: 565 GLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRA 624
+ + R+W ++LA+ L + ++L+ +L+ + E+E + +
Sbjct: 858 LR----------EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE 907
Query: 625 RRSQS----AELNRDLCKAHSALVLAFRGAHRK---QEEQRRKLEQQMALMEAQQAEEVA 677
R+Q+ ++ + K +L+ ++ +Q +L Q M + + ++ E
Sbjct: 908 ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTG 967
Query: 678 VLE 680
+L+
Sbjct: 968 ILQ 970
Score = 45.4 bits (106), Expect = 2e-04
Identities = 97/419 (23%), Positives = 159/419 (37%), Gaps = 60/419 (14%)
Query: 294 EAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCE 353
E ++E + I +L+ L LQG + S+ L QRE E L LQ +
Sbjct: 1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794
Query: 354 EAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSV 413
E L+E LQ+ EA R LAQ + ++A Q+ Q + V
Sbjct: 1795 E-------LKE-----------QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV 1836
Query: 414 DKPTP------QEVAFQLRSYVQRLQER----RSLMKILSEPGPTLAPMPTV---PRAEA 460
+ ++ L+ LQ+ R L + L+ G + + V RAE+
Sbjct: 1837 KEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES 1896
Query: 461 MVQ--AILGTQAGPALP----RLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELRE 514
Q A+L Q A +E +Q + A+ L + L+ +R E + +E
Sbjct: 1897 REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQE 1956
Query: 515 AALR--------ALGPAHVLL--LEQLRWERAELQAG-GANSSGGHSSGGGSSGDEEEWY 563
A R ALG AH L EQ E+AEL A+++ +S +
Sbjct: 1957 EAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE 2016
Query: 564 QGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGR 623
+ L Q G D + QE L + L +++ ++E EQ+ +K
Sbjct: 2017 EALRI-----------QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL 2065
Query: 624 ARRSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQ-QMALMEAQQAEEVAVLEA 681
A+R Q + RG H+ E + L Q + ++E ++ ++ LEA
Sbjct: 2066 AQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEA 2124
Score = 42.4 bits (98), Expect = 0.001
Identities = 96/511 (18%), Positives = 186/511 (36%), Gaps = 59/511 (11%)
Query: 170 QREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCP 229
+REA L E+N L L E+ QA L I+ EKE +QK++ E +
Sbjct: 653 RREA--LWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESR---------- 700
Query: 230 HLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPE 289
+A + EA R+ + L+R L
Sbjct: 701 --HQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVRE--------------KAALEVR 744
Query: 290 MHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYS 349
+ +E + L ++ L LL + L + + + + GQ E + + A +
Sbjct: 745 LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804
Query: 350 EHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPE 409
+ ++ L + + +A L AE+E L Q++AA + Q + +
Sbjct: 805 QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEK 864
Query: 410 GSSVDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQ 469
S + QE+A L S L+ + +++ + T R E QA
Sbjct: 865 ERSWHQ---QELAKALES----LEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALC 917
Query: 470 AGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLE 529
E+ + + L+ ++ LAD +L+ +R++ + +L+E +L
Sbjct: 918 QMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTG------ILQT 971
Query: 530 QLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEK 589
QL+ + EL+ + L A+ +S + ++ E
Sbjct: 972 QLQEAQRELKEAA-----------------RQHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Query: 590 LAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHSALVLAFRG 649
L +L A +++++Q RE ++ + + + A L L + L L +
Sbjct: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRL-LVLQE 1073
Query: 650 AHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
A ++++ L Q M + +Q E A +E
Sbjct: 1074 ADSIRQQELSALRQDMQEAQGEQKELSAQME 1104
Score = 38.5 bits (88), Expect = 0.021
Identities = 128/587 (21%), Positives = 213/587 (36%), Gaps = 85/587 (14%)
Query: 163 QEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSL 222
QE + A E LR + E + +A+LE + + + +EV Q+ +
Sbjct: 1420 QENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQI 1479
Query: 223 LRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLP 282
LE C S E + ++ +R L TQ L
Sbjct: 1480 QELEKCR-------------SVLEHLPMAVQEREQKLTVQREQIRELEKDRETQ-RNVLE 1525
Query: 283 NQPLSPE-----MHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEG-LSMQL-GQR 335
+Q L E + Q++ L+ + L+C L +K C+ L +L GQR
Sbjct: 1526 HQLLELEKKDQMIESQRGQVQDLKKQLVTLECL--ALELEENHHKMECQQKLIKELEGQR 1583
Query: 336 EAEATAL-HLALQYSE------------HCEEAYRVLLA--LREADSGAGDEAPMSD--- 377
E + AL HL L E H E++ +LA L+E D + +
Sbjct: 1584 ETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQ 1643
Query: 378 ------LQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQR 431
Q E+ L+ Q+E Q+ Q + + + +++ LR +
Sbjct: 1644 RQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQ-----TKILEEDLEQIKLSLRERGRE 1698
Query: 432 LQERRSLMKILSEPGP--------TLAPMPTVPR-----AEAMVQAI-----LGTQAGPA 473
L +R LM+ +E G +L M + R E + I L Q
Sbjct: 1699 LTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQ 1758
Query: 474 LPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRW 533
L L + + L+ ++ ++L+ QL ++G EL+E +L++ L Q
Sbjct: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG-ELKEQSLQSQLDEAQRALAQRDQ 1817
Query: 534 ERAELQAGGANSSGGHS----SGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEK 589
E LQ + G G E+ + L G D + R +
Sbjct: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ--DHKEQAR-----R 1870
Query: 590 LAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHSALVLAFRG 649
L +ELA R L+E L LR E + + A + Q AE ++ AL ++
Sbjct: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930
Query: 650 AHRKQEEQRRKLEQQMALMEAQQAEEVAV---LEATARALGKPRPPL 693
A +E+ ++LE A ++ + +E A EA ALGK L
Sbjct: 1931 AQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAAL 1977
Score = 38.1 bits (87), Expect = 0.028
Identities = 115/543 (21%), Positives = 208/543 (38%), Gaps = 82/543 (15%)
Query: 155 GGAGSLGKQEGAGSCQREAARLAERNAWLR-LALSSREDELVRTQASLEAIRAEKETLQK 213
GG S G Q A L +R L L+ + L + L + ++ L+
Sbjct: 1205 GGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRD 1264
Query: 214 EVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHS 273
+VQ+L++ L E H + S ++ ++ WE + + SL L+
Sbjct: 1265 QVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQN-SLESELMEL----- 1318
Query: 274 STQILGSLPNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLG 333
+ + SL ++ E+ MEAQ E+ LL A + + E L +
Sbjct: 1319 -HETMASLQSRLRRAELQRMEAQGER------------ELLQAAKENLTAQVEHLQAAVV 1365
Query: 334 QREAEATALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEE 393
+ A+A+A + E R L L+ + E+ QA +++ +AQ +
Sbjct: 1366 EARAQASAAGIL----EEDLRTARSALKLKNEEV----ESERERAQALQEQGELKVAQGK 1417
Query: 394 AAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMP 453
A + A + V+ LR +Q L+++R + K E L +
Sbjct: 1418 ALQENLALLTQTLAEREEEVET---------LRGQIQELEKQREMQKAALE----LLSLD 1464
Query: 454 TVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQ------LVRREK 507
R + + L++ QIQ+ L R L L + +Q V+RE+
Sbjct: 1465 LKKRNQEV--------------DLQQEQIQE-LEKCRSVLEHLPMAVQEREQKLTVQREQ 1509
Query: 508 -RGLEL-REAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDE-EEWYQ 564
R LE RE L H LL + + + E Q G E EE +
Sbjct: 1510 IRELEKDRETQRNVL--EHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHH 1567
Query: 565 GLPAVPGGTSGIDGGQVGR-------AWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQ 617
+ ++G + + D E+ +QEL A ++ DL+ L REL++
Sbjct: 1568 KMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQE 1627
Query: 618 VAQKGRARRSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVA 677
Q+ +++R Q EL R K H L +++++ ++++ ++E Q+ +
Sbjct: 1628 RDQEVKSQREQIEELQRQ--KEHLTQDL------ERRDQELMLQKERIQVLEDQRTRQTK 1679
Query: 678 VLE 680
+LE
Sbjct: 1680 ILE 1682
Score = 34.3 bits (77), Expect = 0.41
Identities = 30/112 (26%), Positives = 53/112 (47%), Gaps = 13/112 (11%)
Query: 588 EKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRD---LCKAHSALV 644
+KL E +T+DLQ ++ SL +E E + + R Q L ++ L + + L
Sbjct: 438 QKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQ 497
Query: 645 LAFRGAHRKQEEQ----------RRKLEQQMALMEAQQAEEVAVLEATARAL 686
L A ++EEQ R +L++ + +EA+Q+E ++ L AL
Sbjct: 498 LQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREAL 549
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 55.1 bits (131), Expect = 2e-07
Identities = 123/537 (22%), Positives = 192/537 (35%), Gaps = 51/537 (9%)
Query: 164 EGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLL 223
E + RLA R L L +S E + + ++ EK+ LQ+ +QEL+ L
Sbjct: 926 ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 985
Query: 224 RLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDS-FSLAHPLLR-RLRSHSSTQILGSL 281
E + + + E D E Q+S S LL RL SS
Sbjct: 986 AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEE 1045
Query: 282 PNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATA 341
+ L+ EA + + + K + + L + + G L Q+ +++ A
Sbjct: 1046 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1105
Query: 342 LHLALQYSEHCEEAYRVLLALREADSGAGDE--APMSDLQAAEKEAWRLLAQEEAAMDAG 399
L L EE + LA E + GA + + + QAA EA L E A
Sbjct: 1106 LRAQLGRK---EEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1162
Query: 400 AQQNPQPSPE-----GSSVDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPT 454
+Q E G D +LRS +R QE L K L E
Sbjct: 1163 EKQRRDLGEELEALRGELEDTLDSTNAQQELRS--KREQEVTELKKTLEEE--------- 1211
Query: 455 VPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELRE 514
R+ + +Q+ +AL +L +L+ RR K E
Sbjct: 1212 --------------------TRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTR 1251
Query: 515 AALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEE----EWYQGLPAVP 570
AL A L L+ R E + G +GD E E + L
Sbjct: 1252 LALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQ 1311
Query: 571 GGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSA 630
+ G +L++EL+++ + D QE LQ R + + RA +++A
Sbjct: 1312 AELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAA 1371
Query: 631 ELNRDLCKAHSALVLAFR---GAHRKQEEQRRKLEQQMALMEA-QQAEEVAVLEATA 683
L L + +A A R A + E RR+ E++ +EA ++A A EA A
Sbjct: 1372 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEA 1428
Score = 40.4 bits (93), Expect = 0.006
Identities = 127/569 (22%), Positives = 212/569 (37%), Gaps = 110/569 (19%)
Query: 174 ARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSH 233
A+L + L+ AL+ EDE L+++R + L + ++L+ + +
Sbjct: 1108 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK----AE 1163
Query: 234 NQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIM 293
Q G + + E +T DS + A LR R T++ +L + E +
Sbjct: 1164 KQRRDLGEELEALRGELE--DTLDSTN-AQQELRSKREQEVTELKKTLEEETRIHEAAVQ 1220
Query: 294 EA-------------QMEQLR---GSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREA 337
E Q+EQ R G+ EK + L+ + + R E S+Q ++E
Sbjct: 1221 ELRQRHGQALGELAEQLEQARRGKGAWEKTR-----LALEAEVSELRAELSSLQTARQEG 1275
Query: 338 EATALHLALQYSE-----------HCEEAYRVLLALREAD--SGAGDEAP---------M 375
E L LQ E E A ++ A E + SGA +EA +
Sbjct: 1276 EQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKEL 1335
Query: 376 SDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAF------------ 423
S +A +A LL +E A A + E + + + +E A
Sbjct: 1336 SSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQ 1395
Query: 424 -QLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEK--T 480
QL + +R +E ++ E A AEA+ Q + + + RLE+
Sbjct: 1396 AQLSEWRRRQEEEAGALEAGEE-----ARRRAAREAEALTQRL--AEKTETVDRLERGRR 1448
Query: 481 QIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWERAELQA 540
++QQ+L +A DL + QLV ++ + L A + +E ER +A
Sbjct: 1449 RLQQEL---DDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVE----ERERAEA 1501
Query: 541 GGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTR 600
G S + +E+E + L + RA L EL A L+
Sbjct: 1502 EGREREARALSLTRALEEEQEAREELE------------RQNRA-----LRAELEALLSS 1544
Query: 601 TLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHSA------LVLAFRGAHRKQ 654
D+ + + L R Q R+Q EL +L A A V A + H +
Sbjct: 1545 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1604
Query: 655 --------EEQRRKLEQQMALMEAQQAEE 675
EE+RR+L +Q+ E ++ EE
Sbjct: 1605 LQGRDEAGEERRRQLAKQLRDAEVERDEE 1633
Score = 34.7 bits (78), Expect = 0.31
Identities = 57/278 (20%), Positives = 104/278 (37%), Gaps = 26/278 (9%)
Query: 142 SHSGPMEFEGTSEGGAGSLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASL 201
S + +E + EG G L +E Q + L +R L L + S EL ++
Sbjct: 1748 SKAAILEEKRQLEGRLGQL--EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFS 1805
Query: 202 EAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSL 261
+ ++ L++++QEL+ L + H + + ++ ET++ L
Sbjct: 1806 AKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI-L 1864
Query: 262 AHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGY 321
+ L+RR +L + E + + +QL ++K R L +
Sbjct: 1865 SGKLVRRAEKRLKEVVL------QVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEE-- 1916
Query: 322 KGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAA 381
E Q G+R + + +E E R + LR P++
Sbjct: 1917 ----EASRAQAGRRRLQRELEDV----TESAESMNREVTTLRNRLR----RGPLTFTTRT 1964
Query: 382 EKEAWRL---LAQEEAAMDAGAQQNPQPSPEGSSVDKP 416
++ +RL +A +E A +A P P PEGS P
Sbjct: 1965 VRQVFRLEEGVASDEEAEEAQPGSGPSPEPEGSPPAHP 2002
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 55.1 bits (131), Expect = 2e-07
Identities = 123/537 (22%), Positives = 192/537 (35%), Gaps = 51/537 (9%)
Query: 164 EGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLL 223
E + RLA R L L +S E + + ++ EK+ LQ+ +QEL+ L
Sbjct: 918 ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 977
Query: 224 RLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDS-FSLAHPLLR-RLRSHSSTQILGSL 281
E + + + E D E Q+S S LL RL SS
Sbjct: 978 AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEE 1037
Query: 282 PNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATA 341
+ L+ EA + + + K + + L + + G L Q+ +++ A
Sbjct: 1038 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1097
Query: 342 LHLALQYSEHCEEAYRVLLALREADSGAGDE--APMSDLQAAEKEAWRLLAQEEAAMDAG 399
L L EE + LA E + GA + + + QAA EA L E A
Sbjct: 1098 LRAQLGRK---EEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1154
Query: 400 AQQNPQPSPE-----GSSVDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPT 454
+Q E G D +LRS +R QE L K L E
Sbjct: 1155 EKQRRDLGEELEALRGELEDTLDSTNAQQELRS--KREQEVTELKKTLEEE--------- 1203
Query: 455 VPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELRE 514
R+ + +Q+ +AL +L +L+ RR K E
Sbjct: 1204 --------------------TRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTR 1243
Query: 515 AALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEE----EWYQGLPAVP 570
AL A L L+ R E + G +GD E E + L
Sbjct: 1244 LALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQ 1303
Query: 571 GGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSA 630
+ G +L++EL+++ + D QE LQ R + + RA +++A
Sbjct: 1304 AELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAA 1363
Query: 631 ELNRDLCKAHSALVLAFR---GAHRKQEEQRRKLEQQMALMEA-QQAEEVAVLEATA 683
L L + +A A R A + E RR+ E++ +EA ++A A EA A
Sbjct: 1364 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEA 1420
Score = 40.4 bits (93), Expect = 0.006
Identities = 127/569 (22%), Positives = 212/569 (37%), Gaps = 110/569 (19%)
Query: 174 ARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSH 233
A+L + L+ AL+ EDE L+++R + L + ++L+ + +
Sbjct: 1100 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK----AE 1155
Query: 234 NQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIM 293
Q G + + E +T DS + A LR R T++ +L + E +
Sbjct: 1156 KQRRDLGEELEALRGELE--DTLDSTN-AQQELRSKREQEVTELKKTLEEETRIHEAAVQ 1212
Query: 294 EA-------------QMEQLR---GSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREA 337
E Q+EQ R G+ EK + L+ + + R E S+Q ++E
Sbjct: 1213 ELRQRHGQALGELAEQLEQARRGKGAWEKTR-----LALEAEVSELRAELSSLQTARQEG 1267
Query: 338 EATALHLALQYSE-----------HCEEAYRVLLALREAD--SGAGDEAP---------M 375
E L LQ E E A ++ A E + SGA +EA +
Sbjct: 1268 EQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKEL 1327
Query: 376 SDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAF------------ 423
S +A +A LL +E A A + E + + + +E A
Sbjct: 1328 SSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQ 1387
Query: 424 -QLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEK--T 480
QL + +R +E ++ E A AEA+ Q + + + RLE+
Sbjct: 1388 AQLSEWRRRQEEEAGALEAGEE-----ARRRAAREAEALTQRL--AEKTETVDRLERGRR 1440
Query: 481 QIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWERAELQA 540
++QQ+L +A DL + QLV ++ + L A + +E ER +A
Sbjct: 1441 RLQQEL---DDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVE----ERERAEA 1493
Query: 541 GGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTR 600
G S + +E+E + L + RA L EL A L+
Sbjct: 1494 EGREREARALSLTRALEEEQEAREELE------------RQNRA-----LRAELEALLSS 1536
Query: 601 TLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHSA------LVLAFRGAHRKQ 654
D+ + + L R Q R+Q EL +L A A V A + H +
Sbjct: 1537 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1596
Query: 655 --------EEQRRKLEQQMALMEAQQAEE 675
EE+RR+L +Q+ E ++ EE
Sbjct: 1597 LQGRDEAGEERRRQLAKQLRDAEVERDEE 1625
Score = 34.7 bits (78), Expect = 0.31
Identities = 57/278 (20%), Positives = 104/278 (37%), Gaps = 26/278 (9%)
Query: 142 SHSGPMEFEGTSEGGAGSLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASL 201
S + +E + EG G L +E Q + L +R L L + S EL ++
Sbjct: 1740 SKAAILEEKRQLEGRLGQL--EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFS 1797
Query: 202 EAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSL 261
+ ++ L++++QEL+ L + H + + ++ ET++ L
Sbjct: 1798 AKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI-L 1856
Query: 262 AHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGY 321
+ L+RR +L + E + + +QL ++K R L +
Sbjct: 1857 SGKLVRRAEKRLKEVVL------QVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEE-- 1908
Query: 322 KGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAA 381
E Q G+R + + +E E R + LR P++
Sbjct: 1909 ----EASRAQAGRRRLQRELEDV----TESAESMNREVTTLRNRLR----RGPLTFTTRT 1956
Query: 382 EKEAWRL---LAQEEAAMDAGAQQNPQPSPEGSSVDKP 416
++ +RL +A +E A +A P P PEGS P
Sbjct: 1957 VRQVFRLEEGVASDEEAEEAQPGSGPSPEPEGSPPAHP 1994
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 55.1 bits (131), Expect = 2e-07
Identities = 123/537 (22%), Positives = 192/537 (35%), Gaps = 51/537 (9%)
Query: 164 EGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLL 223
E + RLA R L L +S E + + ++ EK+ LQ+ +QEL+ L
Sbjct: 959 ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 1018
Query: 224 RLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDS-FSLAHPLLR-RLRSHSSTQILGSL 281
E + + + E D E Q+S S LL RL SS
Sbjct: 1019 AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEE 1078
Query: 282 PNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATA 341
+ L+ EA + + + K + + L + + G L Q+ +++ A
Sbjct: 1079 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1138
Query: 342 LHLALQYSEHCEEAYRVLLALREADSGAGDE--APMSDLQAAEKEAWRLLAQEEAAMDAG 399
L L EE + LA E + GA + + + QAA EA L E A
Sbjct: 1139 LRAQLGRK---EEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1195
Query: 400 AQQNPQPSPE-----GSSVDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPT 454
+Q E G D +LRS +R QE L K L E
Sbjct: 1196 EKQRRDLGEELEALRGELEDTLDSTNAQQELRS--KREQEVTELKKTLEEE--------- 1244
Query: 455 VPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELRE 514
R+ + +Q+ +AL +L +L+ RR K E
Sbjct: 1245 --------------------TRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTR 1284
Query: 515 AALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEE----EWYQGLPAVP 570
AL A L L+ R E + G +GD E E + L
Sbjct: 1285 LALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQ 1344
Query: 571 GGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSA 630
+ G +L++EL+++ + D QE LQ R + + RA +++A
Sbjct: 1345 AELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAA 1404
Query: 631 ELNRDLCKAHSALVLAFR---GAHRKQEEQRRKLEQQMALMEA-QQAEEVAVLEATA 683
L L + +A A R A + E RR+ E++ +EA ++A A EA A
Sbjct: 1405 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEA 1461
Score = 40.4 bits (93), Expect = 0.006
Identities = 127/569 (22%), Positives = 212/569 (37%), Gaps = 110/569 (19%)
Query: 174 ARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSH 233
A+L + L+ AL+ EDE L+++R + L + ++L+ + +
Sbjct: 1141 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK----AE 1196
Query: 234 NQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIM 293
Q G + + E +T DS + A LR R T++ +L + E +
Sbjct: 1197 KQRRDLGEELEALRGELE--DTLDSTN-AQQELRSKREQEVTELKKTLEEETRIHEAAVQ 1253
Query: 294 EA-------------QMEQLR---GSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREA 337
E Q+EQ R G+ EK + L+ + + R E S+Q ++E
Sbjct: 1254 ELRQRHGQALGELAEQLEQARRGKGAWEKTR-----LALEAEVSELRAELSSLQTARQEG 1308
Query: 338 EATALHLALQYSE-----------HCEEAYRVLLALREAD--SGAGDEAP---------M 375
E L LQ E E A ++ A E + SGA +EA +
Sbjct: 1309 EQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKEL 1368
Query: 376 SDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAF------------ 423
S +A +A LL +E A A + E + + + +E A
Sbjct: 1369 SSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQ 1428
Query: 424 -QLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEK--T 480
QL + +R +E ++ E A AEA+ Q + + + RLE+
Sbjct: 1429 AQLSEWRRRQEEEAGALEAGEE-----ARRRAAREAEALTQRL--AEKTETVDRLERGRR 1481
Query: 481 QIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWERAELQA 540
++QQ+L +A DL + QLV ++ + L A + +E ER +A
Sbjct: 1482 RLQQEL---DDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVE----ERERAEA 1534
Query: 541 GGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTR 600
G S + +E+E + L + RA L EL A L+
Sbjct: 1535 EGREREARALSLTRALEEEQEAREELE------------RQNRA-----LRAELEALLSS 1577
Query: 601 TLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHSA------LVLAFRGAHRKQ 654
D+ + + L R Q R+Q EL +L A A V A + H +
Sbjct: 1578 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1637
Query: 655 --------EEQRRKLEQQMALMEAQQAEE 675
EE+RR+L +Q+ E ++ EE
Sbjct: 1638 LQGRDEAGEERRRQLAKQLRDAEVERDEE 1666
Score = 34.7 bits (78), Expect = 0.31
Identities = 57/278 (20%), Positives = 104/278 (37%), Gaps = 26/278 (9%)
Query: 142 SHSGPMEFEGTSEGGAGSLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASL 201
S + +E + EG G L +E Q + L +R L L + S EL ++
Sbjct: 1781 SKAAILEEKRQLEGRLGQL--EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFS 1838
Query: 202 EAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSL 261
+ ++ L++++QEL+ L + H + + ++ ET++ L
Sbjct: 1839 AKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI-L 1897
Query: 262 AHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGY 321
+ L+RR +L + E + + +QL ++K R L +
Sbjct: 1898 SGKLVRRAEKRLKEVVL------QVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEE-- 1949
Query: 322 KGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAA 381
E Q G+R + + +E E R + LR P++
Sbjct: 1950 ----EASRAQAGRRRLQRELEDV----TESAESMNREVTTLRNRLR----RGPLTFTTRT 1997
Query: 382 EKEAWRL---LAQEEAAMDAGAQQNPQPSPEGSSVDKP 416
++ +RL +A +E A +A P P PEGS P
Sbjct: 1998 VRQVFRLEEGVASDEEAEEAQPGSGPSPEPEGSPPAHP 2035
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 55.1 bits (131), Expect = 2e-07
Identities = 160/691 (23%), Positives = 259/691 (37%), Gaps = 100/691 (14%)
Query: 13 GRHAPPGELDPVAES--SEEVEAASGSSKPSFAPPPVSSGLEQLGPMEEVSGQGLGSRTD 70
GR AP GEL P A E E G S+PS G Q ++ +GQ D
Sbjct: 626 GREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQ--GLDLATGQAEAREHD 683
Query: 71 KKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVF---QTLQHTLS 127
++++G P+ + A+E +Q E PG + L+ ++
Sbjct: 684 QRLEGTVRDPAWQKPQQKSEGALE--------VQVWEGPIPGESLASGVAEQEALREEVA 735
Query: 128 SLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQ-EGAGSCQREAARLAERNAWLRLA 186
L A A + + + +E + T A L K+ A + EA R AE AW
Sbjct: 736 QLRRKAEALGDELEAQARKLEAQNTE---AARLSKELAQARRAEAEAHREAEAQAW---- 788
Query: 187 LSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSG-SSS 245
E R + ++EA E E+ +E + L ++L Q GS +
Sbjct: 789 ------EQARLREAVEAAGQELESASQEREALVEAL----AAAGRERRQWEREGSRLRAQ 838
Query: 246 SEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIE 305
SEA E + +S H + L + + + A++E L+ +E
Sbjct: 839 SEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKE--LGARLEHLQRELE 896
Query: 306 KLKCFNRLLSAVLQGYKGRCEGLSMQL-GQREAEATALHLAL-QYSEHCEEAYRVLLALR 363
+ + + R +GL +L + +A AT+ AL + + L LR
Sbjct: 897 QAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLR 956
Query: 364 EADSGAGDEAPMSDLQAAEKEAWRLLAQEEA----AMDAGAQQNPQPSPEGSSVD-KPTP 418
+ +G G + ++ Q E + RL+ E + + A Q EG +
Sbjct: 957 QGPAGLGPK-KRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRA 1015
Query: 419 QEVAFQ---LRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALP 475
QE+ Q + + RLQ +S+++I G L V E V+A +Q
Sbjct: 1016 QELLLQSQRAQEHSSRLQAEKSVLEI---QGQELHRKLEV--LEEEVRAARQSQE----- 1065
Query: 476 RLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELR----EAALRALGPAHVLLL--- 528
E QQ L+ +ALA L R + E GL +R +A +RAL AH L
Sbjct: 1066 --ETRGQQQALLRDHKALAQLQRRQE---AELEGLLVRHRDLKANMRALELAHRELQGRH 1120
Query: 529 EQLRWERAELQAGG----ANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRA 584
EQL+ +RA ++A A G G EEE + R
Sbjct: 1121 EQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEE-------------------LRRL 1161
Query: 585 WDPEKLAQELAASLTRTL--------DLQEQLQSLRRELEQVAQKGRARRSQSAELNRDL 636
AQ L A L+R +L+ +L L E Q+ + + R + +L+
Sbjct: 1162 QSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSA 1221
Query: 637 CKAHSALVLAFRGAHRKQEEQRRKLEQQMAL 667
C+ + L + ++EE R+ L + AL
Sbjct: 1222 CRLTTQCELLTQLRSAQEEENRQLLAEVQAL 1252
Score = 50.1 bits (118), Expect = 7e-06
Identities = 152/646 (23%), Positives = 223/646 (34%), Gaps = 119/646 (18%)
Query: 141 PSHSGPMEFEGTSEGGAGSLGK--QEGAGSCQREAARLAERNAW-LRLALSSRED----- 192
P P E E S G+L K +E QR A L ER LR SR
Sbjct: 194 PGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPS 253
Query: 193 -----ELVRTQASLEAIRAEKETL-------QKEVQELQDSLLRLEPCPHLSHNQAGGSG 240
+L +A L +R E E Q EVQ L+ + RL QA +
Sbjct: 254 HHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAE 313
Query: 241 SGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQL 300
+EA RE LRR R ++Q+E+
Sbjct: 314 LYREEAEALRE---RAGRLPRLQEELRRCRERLQAA--------------EAYKSQLEEE 356
Query: 301 RGSIEKLKCFNRLLSAVLQGYKGRCEGLS----------MQLGQREAEATAL-HLALQYS 349
R L+ LL L+ + RC L +LG+ AE +L H Q +
Sbjct: 357 RVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLA 416
Query: 350 EHCEEAYRVLLALREADSGAGDEAPMSDL------QAAEKEAWRLLAQEEAAMDA-GAQQ 402
E E L E G+ EAP++ + E EA RL E + G Q
Sbjct: 417 EENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQ 476
Query: 403 NPQPSPEGSSVDKPTPQE--------------VAFQL--RSYVQRLQERRSLMKILSEPG 446
Q P G P+E VAF + VQ+ ++ L+ P
Sbjct: 477 VLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPA 536
Query: 447 -----PTLAPMPTVP-----RAEAMVQAI-----------------LGTQAGPALPRLEK 479
A P P AE+ +QA + TQ P
Sbjct: 537 LDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRS 596
Query: 480 TQIQQDLVAAREALADLMLRLQLVRREKRGLELREA-------ALRALGPAHVLLLEQLR 532
+ VA + + QL+ E G E + LR GP H +
Sbjct: 597 SLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPS 656
Query: 533 WERAELQAGGANSSGGHSSGGGSSGDEEEWYQGL---PAVPGGTSGIDGGQVGRAWDPEK 589
+ E Q G N ++G + + ++ +G PA +G + W+
Sbjct: 657 SVQLEEQEG-PNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPI 715
Query: 590 LAQELAASLTRTLDLQEQLQSLRR-------ELEQVAQKGRARRSQSAELNRDLCKAHSA 642
+ LA+ + L+E++ LRR ELE A+K A+ +++A L+++L +A A
Sbjct: 716 PGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRA 775
Query: 643 LVLAFRGAHRKQEEQRRKLEQQMAL---MEAQQAEEVAVLEATARA 685
A R A + EQ R E A +E+ E A++EA A A
Sbjct: 776 EAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAA 821
Score = 44.7 bits (104), Expect = 3e-04
Identities = 177/768 (23%), Positives = 287/768 (37%), Gaps = 134/768 (17%)
Query: 20 ELDPVAESSEEVEAASGSSKPSFAPPPVSSGLEQLGP-----MEEVSGQGLG-----SRT 69
++D +AE + E+E + S PPP S G L +EV G R
Sbjct: 411 QVDQLAEENVELEL---ELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERE 467
Query: 70 DKKMDG---------GSGRELASAP-EVPHKPAVEAHQAPEAALQYKETVPPG------N 113
++++ G G L AP E P P +E +AP+ + + + P G +
Sbjct: 468 NRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLE--EAPQTPVAFDHS-PQGLVQKARD 524
Query: 114 GAPDVFQTLQHTLSSLEAAAAAWRHQPPSHSGPMEFEGTSEGGA-----GSLGKQEGAGS 168
G P L S+ A+A P S P E E + A QE
Sbjct: 525 GGPQALDLAPPALDSVLEASAECPQAPDSD--PQEAESPLQAAAMDPQASDWSPQESGSP 582
Query: 169 CQ-REAARLAERNAWLRLALSSREDELVRTQ--------ASLEAIRAEKETLQKEVQELQ 219
+ +E+ A R + L+ S + T+ E A + L E L+
Sbjct: 583 VETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLR 642
Query: 220 DSLLRLEPCP------HLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHS 273
+P P L + G ++ +A+ + + ++ P ++ + S
Sbjct: 643 QEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKS 702
Query: 274 STQIL-----GSLPNQPLSP---EMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRC 325
+ G +P + L+ E + ++ QLR E L + L+
Sbjct: 703 EGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEA 762
Query: 326 EGLSMQLGQ---------REAEATA-----LHLALQYS-EHCEEAYRVLLALREADSGAG 370
LS +L Q REAEA A L A++ + + E A + AL EA + AG
Sbjct: 763 ARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822
Query: 371 DEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQ--LRSY 428
E + E+E RL AQ EAA + + ++ ++ A Q L
Sbjct: 823 RER-----RQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKA 877
Query: 429 VQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVA 488
V R +E + ++ L A + R E + + Q L + + ++Q +
Sbjct: 878 VVRGKELGARLEHLQRELEQAA----LERQEFLREKESQHQRYQGLEQRLEAELQAAATS 933
Query: 489 AREALADLMLR-LQLVRREKRGLELREAALRALGPA-----------HVLLLE------Q 530
EAL +L R LQL E+ +LR+ LGP +V L+E
Sbjct: 934 KEEALMELKTRALQL---EEELFQLRQGPA-GLGPKKRAEPQLVETQNVRLIEVERSNAM 989
Query: 531 LRWERAELQA------GGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRA 584
L E+A LQ G S G + + + I G ++ R
Sbjct: 990 LVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRK 1049
Query: 585 WDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAEL------NRDLCK 638
E L +E+ A+ + + Q Q+L R+ + +AQ +R Q AEL +RDL
Sbjct: 1050 L--EVLEEEVRAARQSQEETRGQQQALLRDHKALAQ---LQRRQEAELEGLLVRHRDLKA 1104
Query: 639 AHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLEATARAL 686
AL LA HR+ + + +L+ Q A +EAQ EVA+L R +
Sbjct: 1105 NMRALELA----HRELQGRHEQLQAQRASVEAQ---EVALLAERERLM 1145
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 54.3 bits (129), Expect = 4e-07
Identities = 120/554 (21%), Positives = 216/554 (38%), Gaps = 51/554 (9%)
Query: 163 QEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSL 222
QE +EA +L R L SS E+EL + + + EKE L++EV+ L L
Sbjct: 456 QEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQL 515
Query: 223 LRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRL------------- 269
LE A S S E ++ + +D S +L RL
Sbjct: 516 QFLET------QLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGE 569
Query: 270 RSHSSTQILGSLP---NQPLSPEMHIMEAQMEQLR----GSIEKLKCFNRLLSAVLQGYK 322
++ + + SL +P + + EAQ++ + E+L+ NR L LQ
Sbjct: 570 KNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVV 629
Query: 323 GRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSGA----GDEAPMSDL 378
GR + L +L +A+ AL + E A + LA EA+ + GD+ S L
Sbjct: 630 GRNQLLEGKLQALQADYQAL-------QQRESAIQGSLASLEAEQASIRHLGDQMEASLL 682
Query: 379 QAAE-KEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQRLQERRS 437
+ KEA + E+ A+ + Q E + + +LR+ + Q++
Sbjct: 683 AVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQ 742
Query: 438 LMKIL-SEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADL 496
L+++L +E G PT A + + +QA + + E ++Q +V + A +
Sbjct: 743 LIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVV---DLQAKM 799
Query: 497 MLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSS 556
L + + L + EA LR H L++QL+ + L S G+
Sbjct: 800 RAALDDQDKVQSQLSMAEAVLR----EHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
Query: 557 GDE-----EEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSL 611
+E ++ + L A+ S + +L ++L + T T +L Q+ +L
Sbjct: 856 QEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCAL 915
Query: 612 RRELEQVAQKGRARRSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQ 671
E E+V + + + + L G +++E + KL+ A +
Sbjct: 916 TVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL 975
Query: 672 QAEEVAVLEATARA 685
+ + +A RA
Sbjct: 976 PGLQAQLAQAEQRA 989
Score = 50.8 bits (120), Expect = 4e-06
Identities = 85/376 (22%), Positives = 145/376 (38%), Gaps = 31/376 (8%)
Query: 293 MEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHC 352
MEA + +R + E +K A+LQ +G C+ L ++ Q + A A H L+ E
Sbjct: 677 MEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
Query: 353 EEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSS 412
+ L+ + A+ G P +D +A E A L+Q + + G Q Q
Sbjct: 737 CQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ----AQV 792
Query: 413 VDKPTPQEVAFQLRSYVQR--------LQERRSLMKILSEPGPTL--APMPTVPRAEAMV 462
VD A + VQ L+E ++L++ L E L A + + +
Sbjct: 793 VDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSERE 852
Query: 463 QAILGTQAGPALPRLEKTQ-IQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALG 521
A+ +A A R E+ + +Q++L A+ + + L ++ + A L
Sbjct: 853 GALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGI-- 910
Query: 522 PAHVLLLEQLRWERA------ELQ----AGGANSSGGHSSGGGSSGDEEEWYQGLPAVPG 571
L +E+ R E A ELQ A G G ++E + L A
Sbjct: 911 QVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKA 970
Query: 572 GTSGIDG--GQVGRAWDPEKLAQELAASLTRTL--DLQEQLQSLRRELEQVAQKGRARRS 627
+ G Q+ +A + QE A TL L ++ + L+ ++ ++ R
Sbjct: 971 AAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRG 1030
Query: 628 QSAELNRDLCKAHSAL 643
Q E R L A A+
Sbjct: 1031 QLEEQGRQLQAAEEAV 1046
Score = 40.4 bits (93), Expect = 0.006
Identities = 114/527 (21%), Positives = 202/527 (38%), Gaps = 90/527 (17%)
Query: 170 QREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCP 229
+RE ++ E N S++ ++LV+ E RA E L KE+ LQ+ L
Sbjct: 411 ERERTKVEEVNR----QQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEEL------- 459
Query: 230 HLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPE 289
SG G + + R L+ L +H+S+ E
Sbjct: 460 ---------SGKGQEADQLWRR--------------LQELLAHTSS----------WEEE 486
Query: 290 MHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYS 349
+ + + +Q + E L+ R L+ LQ + + +S + E + L +Q
Sbjct: 487 LAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL---IQDK 543
Query: 350 EHCEEAYRVLLALREADSGAGDEAPMS--------DLQAAEKEAWRLLAQEEAAMDAGAQ 401
+H + +L L G E P++ + ++ +EAW +E+ + AQ
Sbjct: 544 DHLSQQVGMLERLA---GPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQE-AQ 599
Query: 402 QNPQPSPEGSSVD--KPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAE 459
+ EGS + + +E+ +L++ V R Q ++ L A + + E
Sbjct: 600 LDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQ------ADYQALQQRE 653
Query: 460 AMVQAILGT-QAGPALPRLEKTQIQQDLVA---AREALADLMLRLQLVRREKRG--LELR 513
+ +Q L + +A A R Q++ L+A A+EA+ M + + + K G +LR
Sbjct: 654 SAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLR 713
Query: 514 EAA-----LRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPA 568
E L + LE ++ +L G G + + E L A
Sbjct: 714 EEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQL-A 772
Query: 569 VPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQ 628
+ + G+V R + +L A + LD Q+++QS E V ++ + Q
Sbjct: 773 LSQAQLEVHQGEVQRL---QAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQ 829
Query: 629 SAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEE 675
E N L +AH +L Q +R Q+ EAQQ EE
Sbjct: 830 LKEQNEALNRAHVQELL--------QCSEREGALQEERADEAQQREE 868
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 53.9 bits (128), Expect = 5e-07
Identities = 114/532 (21%), Positives = 194/532 (36%), Gaps = 87/532 (16%)
Query: 157 AGSLGKQEGAGSCQREAARLAERNAW------------LRLALSSREDELVRTQASLEAI 204
AG L + G G+ +REA R + L+LA +E +L + + A+
Sbjct: 1198 AGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAV 1257
Query: 205 RAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHP 264
E L+ +QE++ S RLE L + S ++ RE E Q +L
Sbjct: 1258 GKEAGELRTGLQEVERS--RLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGER 1315
Query: 265 LLRRLRSHS----STQILGSLPNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQG 320
+ R + + G + + E+ + + ++++ G + + R L L+
Sbjct: 1316 AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEG---EFRTRERRLLGSLEE 1372
Query: 321 YKG-------RCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSGAGDEA 373
+G GL ++L AEA L L L +E + LA E A EA
Sbjct: 1373 ARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAA-EA 1431
Query: 374 PMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQRLQ 433
+ L++A + L G +P P P S + P E + + + L+
Sbjct: 1432 QLGGLRSALRRGLGL----------GRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLE 1481
Query: 434 ERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREAL 493
PG + P P G PA P L D A R AL
Sbjct: 1482 ---------CSPG-SQPPSP-------------GPATSPASPDL-------DPEAVRGAL 1511
Query: 494 ADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGG 553
+ + L+ +RE+ L + +AL + AE++A +++
Sbjct: 1512 REFLQELRSAQRERDELRTQTSALNR--------------QLAEMEAERDSATSRARQLQ 1557
Query: 554 GSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRR 613
+ + EE +V G SG+ + + +E A+L + L+ LQ+
Sbjct: 1558 KAVAESEE---ARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATES 1614
Query: 614 ELEQVAQKGRARRSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQM 665
EL +K ++ +L D + L A K E QRR LE ++
Sbjct: 1615 ELRASQEKISKMKANETKLEGDKRRLKEVLD-ASESRTVKLELQRRSLEGEL 1665
Score = 49.3 bits (116), Expect = 1e-05
Identities = 125/539 (23%), Positives = 205/539 (38%), Gaps = 90/539 (16%)
Query: 193 ELVRTQASLEAIRAEKETLQKEVQELQDSLLRL------------EPCPHLSHNQAGGSG 240
EL R+ LE + ++ L KE+ E++++L R E L+ +AG
Sbjct: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE 719
Query: 241 SGSSSSEADREPWETQDSFSLAHPLLRRLRSHSS--TQILGSLPNQPLSPEMHIMEAQME 298
S ++ E QDS S L L +++ L + + + +A+ E
Sbjct: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
Query: 299 QL--RGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEA------TALHLALQYSE 350
R E+L+ QG +G S+++ ++ EA T H Q E
Sbjct: 780 ATVAREEQERLEELRLEQEVARQGLEG-----SLRVAEQAQEALEQQLPTLRHERSQLQE 834
Query: 351 HCEEAYRVLLA----LREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMD----AGAQQ 402
+ R L L +A A + + A EKEA LA+E A + A ++
Sbjct: 835 QLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEA---LAKEHAGLAVQLVAAERE 891
Query: 403 NPQPSPEGSSV--DKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEA 460
S E + + +K + F+++ + +L+ RR ++ + LA
Sbjct: 892 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ-ALLLAKETLTGELAG 950
Query: 461 MVQAILGTQAGPALPRLEKTQIQQDLVAA-REALADLMLR-------LQLVRREKRGLEL 512
+ Q I+ TQ +L +K + Q LV A REA A L + LQ ++REK
Sbjct: 951 LRQQIIATQEKASL---DKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREK----- 1002
Query: 513 REAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGG 572
EAA R L L QL+ E+ EL A ++EE + + A+
Sbjct: 1003 -EAAWRELEAERAQLQSQLQREQEELLAR-------------LEAEKEELSEEIAALQ-- 1046
Query: 573 TSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVA-QKGRARRSQSAE 631
G + Q L+ + L E+L R L ++ + R +R +
Sbjct: 1047 ----QERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSR 1102
Query: 632 LNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLEATARALGKPR 690
+D + AL R ++EE A A+EV L+ AR LGK R
Sbjct: 1103 QEQDRSTVN-ALTSELRDLRAQREEAA-----------AAHAQEVRRLQEQARDLGKQR 1149
Score = 45.8 bits (107), Expect = 1e-04
Identities = 121/550 (22%), Positives = 199/550 (36%), Gaps = 74/550 (13%)
Query: 161 GKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQD 220
G + QRE RL N L S+ L Q E +R E+E LQ +EL+
Sbjct: 579 GAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRR 638
Query: 221 SLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGS 280
RLE + E +R + + L + L +
Sbjct: 639 QRDRLE-----EEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRAT 693
Query: 281 LPNQPLSPE-MHIMEAQMEQLRGSIEKLKCFNRLLS--AVLQGYKGRCEGLSMQLGQREA 337
L L E + EA + G +E +L + A LQ + L+ L Q +
Sbjct: 694 LQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL 753
Query: 338 EATALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWR----LLAQEE 393
+ L L+ + + R A +EA ++ + +L+ ++ A + L E
Sbjct: 754 DLNRLVAQLEEEKSALQG-RQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAE 812
Query: 394 AAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQRL-QERRSLMKILSEPGPTLAPM 452
A +A QQ P E S + + Q ++ QL Q L Q RR + +
Sbjct: 813 QAQEALEQQLPTLRHERSQLQEQLAQ-LSRQLSGREQELEQARREAQRQVEALERAAREK 871
Query: 453 PTVPRAEA--MVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGL 510
+ + A VQ + + G L E T+++ + +EAL + +Q R+ L
Sbjct: 872 EALAKEHAGLAVQLVAAEREGRTLSE-EATRLRLE----KEALEGSLFEVQ---RQLAQL 923
Query: 511 ELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVP 570
E R L A G A +L E L E A L+
Sbjct: 924 EARREQLEAEGQALLLAKETLTGELAGLR------------------------------- 952
Query: 571 GGTSGIDGGQVGRAWDPEKLAQELA-ASLTRTLDLQEQ-------LQSLRRELEQVAQKG 622
I Q + D E +AQ+L A L+EQ LQ L+RE E ++
Sbjct: 953 ---QQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWREL 1009
Query: 623 RARRSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQ----MALMEAQQAEEVAV 678
A R A+L L + L+ + E+ L+Q+ + L E+++ + +++
Sbjct: 1010 EAER---AQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSL 1066
Query: 679 LEATARALGK 688
E+ AL +
Sbjct: 1067 KESEKTALSE 1076
Score = 45.8 bits (107), Expect = 1e-04
Identities = 120/540 (22%), Positives = 207/540 (38%), Gaps = 117/540 (21%)
Query: 168 SCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEP 227
+ +RE L+E LRL + E L Q L + A +E L+ E Q L LL E
Sbjct: 887 AAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQAL---LLAKET 943
Query: 228 CPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLS 287
L+ AG ++ TQ+ SL L+ + + + SL Q +
Sbjct: 944 ---LTGELAG----------LRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAA 990
Query: 288 PEMHI-------------MEAQMEQLRGSIEK--------LKCFNRLLS---AVLQGYKG 323
E + +EA+ QL+ +++ L+ LS A LQ +
Sbjct: 991 HEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQ--QE 1048
Query: 324 RCEGLSMQ-------LGQREAEATALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMS 376
R EGL + L +E+E TAL L + H + + ++ D+ + E S
Sbjct: 1049 RDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRS 1108
Query: 377 DLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQRLQERR 436
+ A E L AQ E A A AQ+ + + + K Q S ++ +E R
Sbjct: 1109 TVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGK--------QRDSCLREAEELR 1160
Query: 437 SLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADL 496
+ +++L + L R E + Q+ L ++E
Sbjct: 1161 TQLRLLEDARDGL--------------------------RRELLEAQRKLRESQEG---- 1190
Query: 497 MLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSS 556
+ V+R++ G ELR R+LG E LR EL++ + S ++
Sbjct: 1191 ----REVQRQEAG-ELR----RSLGEG-AKEREALRRSNEELRSAVKKAESERISLKLAN 1240
Query: 557 GDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELE 616
D+E Q L + + + K A EL L +++ RREL+
Sbjct: 1241 EDKE---QKLALLEEARTAVG-----------KEAGELRTGLQ---EVERSRLEARRELQ 1283
Query: 617 QVAQKGRARRSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEV 676
++ ++ + S++ L R+L + L L G ++E +R L + L++ + + EV
Sbjct: 1284 ELRRQMKMLDSENTRLGRELAELQGRLAL---GERAEKESRRETLGLRQRLLKGEASLEV 1340
Score = 43.1 bits (100), Expect = 9e-04
Identities = 137/672 (20%), Positives = 244/672 (36%), Gaps = 119/672 (17%)
Query: 40 PSFAPPPVSSGLEQLGPMEEVSGQGLGSRTDKKMDGGSGRELASAPEVPHKPAVEAHQAP 99
PS AP PV + P E SG+GL S + + GS P P ++
Sbjct: 1450 PSPAPRPVPGSPARDAPAEG-SGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVR 1508
Query: 100 EAALQYKETVPPGNGAPDVFQTLQHTLSSLEAAAAAWRHQPPSHSGPM-----EFEGTSE 154
A ++ + + D +T L+ A A R S + + E E
Sbjct: 1509 GALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARR 1568
Query: 155 GGAGSLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKE 214
G L + + Q E+ R +ER L D++ + SL+A +E Q++
Sbjct: 1569 SVDGRLSGVQAELALQEESVRRSERERRATL------DQVATLERSLQATESELRASQEK 1622
Query: 215 VQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSS 274
+ +++ + +LE S S + E R E + S R ++ +
Sbjct: 1623 ISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQAL 1682
Query: 275 TQILGSLPNQPLSPEMHI--MEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQL 332
+ SL Q E+ ++ +E+L G++ K++ L + + GL+ L
Sbjct: 1683 QDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGAL-------RDKVRGLTEAL 1735
Query: 333 GQREAEATALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQE 392
Q A +L+ + H ++A L A E + L +
Sbjct: 1736 AQSSA---SLNSTRDKNLHLQKA----------------------LTACEHDRQVLQERL 1770
Query: 393 EAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQ--RLQERRSLMKILSEPGPTLA 450
+AA A ++ Q S G V + +L+ +LQ+ R +++ E A
Sbjct: 1771 DAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEG--EAA 1828
Query: 451 PMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGL 510
+ TV + + E+ +Q+ L + + ALA L + V R L
Sbjct: 1829 ALNTVQKLQD-----------------ERRLLQERLGSLQRALAQLEAEKREVERSALRL 1871
Query: 511 ELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVP 570
E ALR L+++ ER +L++ H S ++
Sbjct: 1872 EKDRVALRR-------TLDKV--EREKLRS--------HEDTVRLSAEK----------- 1903
Query: 571 GGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRR-----ELEQVAQKGRAR 625
G++ R +L ELA + + L+ Q+ L + +LE AQ+ +
Sbjct: 1904 --------GRLDRTLTGAEL--ELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLE 1953
Query: 626 RSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLEATARA 685
Q E R + A AHR ++ R LE+Q++ ++ Q +E+ R+
Sbjct: 1954 LQQEVERLRSAQAQTERTLEARERAHR---QRVRGLEEQVSTLKGQLQQEL------RRS 2004
Query: 686 LGKPRPPLPPPQ 697
PP PP+
Sbjct: 2005 SAPFSPPSGPPE 2016
Score = 40.0 bits (92), Expect = 0.007
Identities = 123/556 (22%), Positives = 195/556 (35%), Gaps = 96/556 (17%)
Query: 157 AGSLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQ 216
A LGKQ SC REA L + L A EL+ Q L + +E ++E
Sbjct: 1142 ARDLGKQRD--SCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG 1199
Query: 217 ELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQ 276
EL+ SL G G+ EA R E L ++ S +
Sbjct: 1200 ELRRSL-----------------GEGAKEREALRRSNEE---------LRSAVKKAESER 1233
Query: 277 ILGSLPNQPLSPEMHIMEA-------QMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLS 329
I L N+ ++ ++E + +LR +++++ LQ + + + L
Sbjct: 1234 ISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD 1293
Query: 330 MQLGQREAEATALHLALQYSEHCE-EAYRVLLALREA--DSGAGDEAPMSDLQAAEKEAW 386
+ + E L L E E E+ R L LR+ A E +LQ A+
Sbjct: 1294 SENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQ---- 1349
Query: 387 RLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPG 446
R L ++E E + R + L+E R K +
Sbjct: 1350 RKLQEQEG-------------------------EFRTRERRLLGSLEEARGTEKQQLDHA 1384
Query: 447 PTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRRE 506
L RAEA A LG + A R + + + V + A+ L L
Sbjct: 1385 RGLELKLEAARAEA---AELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLG-GLRSAL 1440
Query: 507 KRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGL 566
+RGL L A A P R AE G NS GS
Sbjct: 1441 RRGLGLGRAPSPAPRPVPG---SPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG----- 1492
Query: 567 PAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARR 626
PA + +D V A + QEL ++ +L+ Q +L R+L ++ + +
Sbjct: 1493 PATSPASPDLDPEAVRGAL--REFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSAT 1550
Query: 627 SQSAELNRDLCKAHSA--------------LVLAFRGAHRKQEEQRRKLEQQMALMEAQQ 672
S++ +L + + ++ A L L R + E+R L+Q L + Q
Sbjct: 1551 SRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQ 1610
Query: 673 AEEVAVLEATARALGK 688
A E + L A+ + K
Sbjct: 1611 ATE-SELRASQEKISK 1625
Score = 34.3 bits (77), Expect = 0.41
Identities = 129/605 (21%), Positives = 222/605 (36%), Gaps = 103/605 (17%)
Query: 120 QTLQHTLSSLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAGSCQREAARLAER 179
Q LQ LS +E A R + + +++ SE +L + G Q E L +
Sbjct: 84 QLLQQELSRVEDLLAQSRAERDELA--IKYNAVSERLEQALRLEPGELETQ-EPRGLVRQ 140
Query: 180 NAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEP-CPHLSHNQAGG 238
+ LR L ++E + L+A + ++ + VQ LQ +L+ + C L
Sbjct: 141 SVELRRQL---QEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLER 197
Query: 239 SGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQME 298
SG D T+ S L L+R + L +
Sbjct: 198 SGELEQQRLRD-----TEHSQDLESALIRLEEEQQRSASLAQVN---------------A 237
Query: 299 QLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAY-- 356
LR +++ N+ LS ++ +L REA A + E AY
Sbjct: 238 MLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREA-------AWRREEESFNAYFS 290
Query: 357 ----RVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSS 412
R+LL R+ G +S+++ + L E A Q+ G
Sbjct: 291 NEHSRLLLLWRQV---VGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLR 347
Query: 413 VDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPT-VPRAEAMVQAILGTQAG 471
+ + + E A + ++ +Q E + K+L E M + + +A+ + T+ G
Sbjct: 348 LAE-SRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARV---TELG 403
Query: 472 PALPRLEKT-----QIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVL 526
A+ RLEK Q+ +DL EAL L L+ Q + G L++ LR L A
Sbjct: 404 LAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQ-TLRDLAQA--- 459
Query: 527 LLEQLRWERAELQAGGANSSGGHSSGG--GSSGDEEEWYQGLPAVPGGTSGIDGGQVGRA 584
L + +Q G+ + S+G G SG Q P+ P +S G R
Sbjct: 460 ---VLSDSESGVQLSGSERTADASNGSLRGLSG------QRTPSPPRRSSPGRGRSPRRG 510
Query: 585 WDPE----------------------------KLAQELAASLTRTL-DLQEQLQSLRREL 615
P + +Q+L +L + L D + + ++L +L
Sbjct: 511 PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQL 570
Query: 616 EQVAQKGRARRSQSAELNRDLCKAHSALVLAFRG----AHRKQ--EEQRRKLEQQMALME 669
+++ K + R++ + SA L R AH Q ++Q +L Q+ ++
Sbjct: 571 QRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQ 630
Query: 670 AQQAE 674
A Q E
Sbjct: 631 AAQEE 635
Score = 33.5 bits (75), Expect = 0.69
Identities = 80/355 (22%), Positives = 130/355 (36%), Gaps = 65/355 (18%)
Query: 199 ASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDS 258
ASL +++ E + LQ+E+ ++D L S +E D +
Sbjct: 74 ASLLSLQEENQLLQQELSRVEDLL-------------------AQSRAERDELAIKYNAV 114
Query: 259 FSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLR-------GSIEKLKCFN 311
LR TQ L Q + + E Q R G + +
Sbjct: 115 SERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQ 174
Query: 312 RLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREA------ 365
RL +LQ YK RC L QL +R E L+ +EH ++ L+ L E
Sbjct: 175 RLQGKILQ-YKKRCSELEQQLLERSGELE--QQRLRDTEHSQDLESALIRLEEEQQRSAS 231
Query: 366 -------------DSGAGDEAPMSDLQAAEKEAWRL---LAQEEAAMDAGAQQ-NPQPSP 408
+G+ ++A D++ + R L EAA + N S
Sbjct: 232 LAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSN 291
Query: 409 EGSSVDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGT 468
E S + Q V F+ ++ R L+++ E T + A+ +A LG
Sbjct: 292 EHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELART---------SRAVQEAGLGL 342
Query: 469 QAGPAL--PRLEKTQIQQDLVAAR--EALADLMLRLQLVRREKRGLELREAALRA 519
G L R E +Q L+ A+ E L D +LR + + +++ +L +A L A
Sbjct: 343 STGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSA 397
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 52.4 bits (124), Expect = 1e-06
Identities = 110/563 (19%), Positives = 214/563 (38%), Gaps = 80/563 (14%)
Query: 162 KQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQA---SLEAIRAEKETLQKEVQEL 218
K E A +RE RL E N L ++S E + +A + ++ E TL+K + L
Sbjct: 626 KGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTL 685
Query: 219 QDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQIL 278
Q+ L+LE G + + D E E + L+ +R S+
Sbjct: 686 QNVSLQLE-------------GLERDNKQLDAENLELRR-------LVETMRFTSTKLAQ 725
Query: 279 GSLPNQPLSPE----------MHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGL 328
NQ L E + + + E+L S + + N L L+ + + L
Sbjct: 726 MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTL 785
Query: 329 SMQLGQREAEATALHLALQ----YSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKE 384
+LG+ EAE AL L+ + E A + AL + + + + + +A K
Sbjct: 786 ESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEA--KR 843
Query: 385 AWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTP--QEVAFQLRSYVQRLQERRSLMKIL 442
W+ + ++A +D + E ++DK ++ A +L+ + ++ R L K +
Sbjct: 844 LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLK---ELEKDNRDLTKQV 900
Query: 443 SEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAR------------ 490
+ TL + E + L ++ LEK + ++L+
Sbjct: 901 TVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKIL 960
Query: 491 EALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGG-- 548
E + L+ L +E++ + L EA + + L +L+ + E + N G
Sbjct: 961 EGRNESALKTTLAMKEEK-IVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQH 1019
Query: 549 ------HSSG--GGSSGDEEEWYQG-------LPAVPGGTSGIDGGQVGRAWDPEKLAQE 593
H +G S +E W G L V ++ + + L ++
Sbjct: 1020 LQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQ 1079
Query: 594 LAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAEL---NRDLCKAHSALVLAF--- 647
L T+ + Q+ +L+++ + + ++Q+A+L N L +AL +
Sbjct: 1080 LQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLL 1139
Query: 648 RGAHRKQEEQRRKLEQQMALMEA 670
+ H +E + L++Q + A
Sbjct: 1140 QNHHTAKETENESLQRQQEQLTA 1162
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 50.1 bits (118), Expect = 7e-06
Identities = 114/535 (21%), Positives = 197/535 (36%), Gaps = 53/535 (9%)
Query: 187 LSSREDELVRTQASLEAIRAEKETLQKE-VQELQDSLLRLEPCPHLSHNQAGGSGSGSSS 245
+ S + +++ L +E TL + ++ + ++L R+E L+ Q +
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 246 SEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIE 305
EA E Q + AH + + ++ + + + E ++AQ +Q R E
Sbjct: 1365 VEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1420
Query: 306 KLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREA 365
+L+ + A +Q + E + E E + L L+ +E
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR------------ 1468
Query: 366 DSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQL 425
GA E +A E EA + AQEEA Q+ + V+ + + +
Sbjct: 1469 -GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1527
Query: 426 RSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRL-------- 477
QR + +++ +E V RA VQ L T A L
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETAQRSAEAELQSKRASFA 1586
Query: 478 EKT-QIQQDLVAAREALADLMLRLQLVRREKRGLEL---REAALRALGPAHV-------- 525
EKT Q+++ L A+A L R + RR ++ E RE A R L +
Sbjct: 1587 EKTAQLERSLQEEHVAVAQL--REEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 526 -LLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGG-QVGR 583
L E++ +++ QA G EE Q + ++ Q+
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQLAE 1702
Query: 584 AWDPEKLA--QELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHS 641
++LA QEL T ++Q Q L EL ++ ++ A + EL +L K +
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762
Query: 642 ALVLAFRGAHRKQEEQRRKLEQQMALMEAQQ------AEEVAVLEATARALGKPR 690
+ + R +EE R E+ +EA+ AEE A L A A + R
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Score = 47.0 bits (110), Expect = 6e-05
Identities = 143/668 (21%), Positives = 244/668 (36%), Gaps = 133/668 (19%)
Query: 68 RTDKKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQTLQHTLS 127
R ++ + S R+L A E K +A A+Q KE ++ QTLQ S
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--------ELQQTLQQEQS 2074
Query: 128 SLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAG-SCQREAARLAER-NAWLRL 185
L+ + G +E + + E A +REAA+ + RL
Sbjct: 2075 VLD-----------------QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 186 ALSSREDELVRTQASLEAIRAEKETLQKEVQELQ--DSLLRLEPCPHLSHNQAGGSGSGS 243
S+ E R QA A + KE Q+ + Q + LR + + +
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 244 SSSEADREPW---------ETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIME 294
+A E ET +L L+RL++ ++ + + E+ +
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE---AARQRSQVEEELFSVR 2234
Query: 295 AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEAT--ALHLALQYSEHC 352
QME+L +++ NR L R + + + Q EAE A + S
Sbjct: 2235 VQMEELSKLKARIEAENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 353 EEAYRVLLALRE--ADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEG 410
+EA R+ E A A E + + A +EA RL A+ E QQ + + E
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL-----QQQKELAQEQ 2342
Query: 411 SSVDKPTPQEVAFQLRSYVQRLQ-----ERRSLMKILSEPGPTLAPMPTVPRAEAMVQ-- 463
+ + +++A QL Q Q ER+ +++ +E + + RA+A +
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2402
Query: 464 -----------------AILGTQAGPALPRLEKTQIQQ---DLVAAREALADLMLRLQLV 503
L TQ L + + Q QQ D REA+A+L + +
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462
Query: 504 RREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWY 563
++E + L+L+ ++ + EQL E LQ + S E +
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQ------EQLLQETQALQQSFLSEKD-------SLLQRERFI 2509
Query: 564 QGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGR 623
+ A KL Q + + L+E+ Q ++++EQ Q+
Sbjct: 2510 EQEKA--------------------KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 624 ARRSQSAELNRDLCKAHSALVLAFRGAHRKQEE------QRRKLEQQMALMEAQQAEEVA 677
A ++ + A G RKQEE QRR+ E+ +A + E++
Sbjct: 2550 ASMEEARRRQHE----------AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 678 VLEATARA 685
+LE RA
Sbjct: 2600 LLEEQHRA 2607
Score = 45.8 bits (107), Expect = 1e-04
Identities = 123/564 (21%), Positives = 211/564 (37%), Gaps = 76/564 (13%)
Query: 159 SLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQEL 218
+L KQ +A AER A + ++E+VR + + + +K ++Q+E+Q+L
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 219 QDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQIL 278
+ S ++A + A+R ++ + RL+ ++ +
Sbjct: 1426 RQS------------SEAEIQAKARQAEAAERSRLRIEEEIRVV-----RLQLEATERQR 1468
Query: 279 GSLPN--QPLSPEMHIMEAQMEQLRGSIEKLK------CFNRLLSAVLQGYKGRCEGLSM 330
G Q L EAQ Q + E+L+ + + V + + E +
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 331 QLGQREAEATALHLALQYSE--------HCEEAYRVLLALREADSGAGDEAPMSDLQAAE 382
+ QR +A L LQ E E A +V +AL A A E AE
Sbjct: 1529 REKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 383 KEAW--RLLAQEEAA---MDAGAQQNPQPSPEGSSVDKPTPQEV---------AFQLRSY 428
K A R L +E A + A++ Q E + +E+ A +LR
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 429 VQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQ-----IQ 483
+ + +++SL + +E A R +A QA+ Q A LEK +
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEKQRQLAEGTA 1705
Query: 484 QDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWE----RAELQ 539
Q +AA + L L + ++++ LE A L+ A ++L E RAE++
Sbjct: 1706 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 540 AGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLT 599
A+ + +S E+ Q L A + G+ + + LA
Sbjct: 1766 VLLASKARAEEESRSTS---EKSKQRLEA--------EAGRFRELAEEAARLRALAEEAK 1814
Query: 600 RTLDL-QEQLQSLRRELEQVAQKGRARRSQSAELNRD---LCKAHSALVLAFRGAHRKQE 655
R L +E R E E+V + A ++ L + K A R +
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 656 EQRRKLEQQMALMEAQQAEEVAVL 679
QRR+LE+Q A +A E +A L
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQL 1898
Score = 39.3 bits (90), Expect = 0.013
Identities = 111/528 (21%), Positives = 196/528 (37%), Gaps = 49/528 (9%)
Query: 168 SCQREAARLAERNAWLRLALSSREDEL-VRTQASLEAIR-----AEKETLQKEVQELQDS 221
S ++ AA AE L S+ ED L + QA LEA R AE+E ++E +E
Sbjct: 1933 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 222 LLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSL 281
L E + ++ E +R + ++ A L R S+ Q+ L
Sbjct: 1993 SLAAE--------EEAARQRKAALEEVERLKAKVEE----ARRLRERAEQESARQL--QL 2038
Query: 282 PNQPLSPEMHIME-AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQ-REAEA 339
+ + E A ++ ++L+ + +VL +G E + EA
Sbjct: 2039 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098
Query: 340 TALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAG 399
A A Q EEA R+ A ++A A E R A++EAA A
Sbjct: 2099 QAEREAAQSRRQVEEAERL-------KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2151
Query: 400 AQQNPQPSPEGSSVDKPTPQEVAFQ-LRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRA 458
A+Q + + + ++ A Q LR Q QE +L L E T +
Sbjct: 2152 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---------TDHQK 2202
Query: 459 EAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREA-AL 517
+ + + +A +++Q++++L + R + +L + E R L LR+
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 518 RALGPAHVLLLEQLRWERAEL-----QAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGG 572
+ ++Q+ E A L +A + E+ + + AV
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 573 TSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAEL 632
T + ++LAQE A L D ++ Q L E + + A R + E+
Sbjct: 2323 TR--LKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 633 NRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
+ + + + R R +E+ +R +Q + E E+A E
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Score = 31.2 bits (69), Expect = 3.4
Identities = 52/200 (26%), Positives = 88/200 (44%), Gaps = 18/200 (9%)
Query: 200 SLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSF 259
SLE E+ Q+ + EL+D L+LE C + ++ + E + E Q +
Sbjct: 971 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1030
Query: 260 SLAHPL---LRRLRSHSSTQILGSLPNQPLSP----EMHIMEAQMEQLRG----SIEKLK 308
+ L + RL S + ++L P +P E+ + ++EQ+R +EKLK
Sbjct: 1031 AEVEGLGKGVARL-SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1089
Query: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSG 368
+S V++G +G E L Q + EA A+ L E + + + L A EA
Sbjct: 1090 ----TISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQP 1144
Query: 369 AGDEAPMSDLQAAEKEAWRL 388
D A +L+ A++ RL
Sbjct: 1145 TFD-ALRDELRGAQEVGERL 1163
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 50.1 bits (118), Expect = 7e-06
Identities = 114/535 (21%), Positives = 197/535 (36%), Gaps = 53/535 (9%)
Query: 187 LSSREDELVRTQASLEAIRAEKETLQKE-VQELQDSLLRLEPCPHLSHNQAGGSGSGSSS 245
+ S + +++ L +E TL + ++ + ++L R+E L+ Q +
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1368
Query: 246 SEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIE 305
EA E Q + AH + + ++ + + + E ++AQ +Q R E
Sbjct: 1369 VEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1424
Query: 306 KLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREA 365
+L+ + A +Q + E + E E + L L+ +E
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR------------ 1472
Query: 366 DSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQL 425
GA E +A E EA + AQEEA Q+ + V+ + + +
Sbjct: 1473 -GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1531
Query: 426 RSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRL-------- 477
QR + +++ +E V RA VQ L T A L
Sbjct: 1532 AREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETAQRSAEAELQSKRASFA 1590
Query: 478 EKT-QIQQDLVAAREALADLMLRLQLVRREKRGLEL---REAALRALGPAHV-------- 525
EKT Q+++ L A+A L R + RR ++ E RE A R L +
Sbjct: 1591 EKTAQLERSLQEEHVAVAQL--REEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1648
Query: 526 -LLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGG-QVGR 583
L E++ +++ QA G EE Q + ++ Q+
Sbjct: 1649 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQLAE 1706
Query: 584 AWDPEKLA--QELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHS 641
++LA QEL T ++Q Q L EL ++ ++ A + EL +L K +
Sbjct: 1707 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1766
Query: 642 ALVLAFRGAHRKQEEQRRKLEQQMALMEAQQ------AEEVAVLEATARALGKPR 690
+ + R +EE R E+ +EA+ AEE A L A A + R
Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821
Score = 47.0 bits (110), Expect = 6e-05
Identities = 143/668 (21%), Positives = 244/668 (36%), Gaps = 133/668 (19%)
Query: 68 RTDKKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQTLQHTLS 127
R ++ + S R+L A E K +A A+Q KE ++ QTLQ S
Sbjct: 2027 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--------ELQQTLQQEQS 2078
Query: 128 SLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAG-SCQREAARLAER-NAWLRL 185
L+ + G +E + + E A +REAA+ + RL
Sbjct: 2079 VLD-----------------QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2121
Query: 186 ALSSREDELVRTQASLEAIRAEKETLQKEVQELQ--DSLLRLEPCPHLSHNQAGGSGSGS 243
S+ E R QA A + KE Q+ + Q + LR + + +
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2181
Query: 244 SSSEADREPW---------ETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIME 294
+A E ET +L L+RL++ ++ + + E+ +
Sbjct: 2182 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE---AARQRSQVEEELFSVR 2238
Query: 295 AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEAT--ALHLALQYSEHC 352
QME+L +++ NR L R + + + Q EAE A + S
Sbjct: 2239 VQMEELSKLKARIEAENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291
Query: 353 EEAYRVLLALRE--ADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEG 410
+EA R+ E A A E + + A +EA RL A+ E QQ + + E
Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL-----QQQKELAQEQ 2346
Query: 411 SSVDKPTPQEVAFQLRSYVQRLQ-----ERRSLMKILSEPGPTLAPMPTVPRAEAMVQ-- 463
+ + +++A QL Q Q ER+ +++ +E + + RA+A +
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2406
Query: 464 -----------------AILGTQAGPALPRLEKTQIQQ---DLVAAREALADLMLRLQLV 503
L TQ L + + Q QQ D REA+A+L + +
Sbjct: 2407 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2466
Query: 504 RREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWY 563
++E + L+L+ ++ + EQL E LQ + S E +
Sbjct: 2467 QQEAKLLQLKSEEMQTVQQ------EQLLQETQALQQSFLSEKD-------SLLQRERFI 2513
Query: 564 QGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGR 623
+ A KL Q + + L+E+ Q ++++EQ Q+
Sbjct: 2514 EQEKA--------------------KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553
Query: 624 ARRSQSAELNRDLCKAHSALVLAFRGAHRKQEE------QRRKLEQQMALMEAQQAEEVA 677
A ++ + A G RKQEE QRR+ E+ +A + E++
Sbjct: 2554 ASMEEARRRQHE----------AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603
Query: 678 VLEATARA 685
+LE RA
Sbjct: 2604 LLEEQHRA 2611
Score = 45.8 bits (107), Expect = 1e-04
Identities = 123/564 (21%), Positives = 211/564 (37%), Gaps = 76/564 (13%)
Query: 159 SLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQEL 218
+L KQ +A AER A + ++E+VR + + + +K ++Q+E+Q+L
Sbjct: 1372 ALEKQRQLAEAHAQAKAQAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429
Query: 219 QDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQIL 278
+ S ++A + A+R ++ + RL+ ++ +
Sbjct: 1430 RQS------------SEAEIQAKARQAEAAERSRLRIEEEIRVV-----RLQLEATERQR 1472
Query: 279 GSLPN--QPLSPEMHIMEAQMEQLRGSIEKLK------CFNRLLSAVLQGYKGRCEGLSM 330
G Q L EAQ Q + E+L+ + + V + + E +
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1532
Query: 331 QLGQREAEATALHLALQYSE--------HCEEAYRVLLALREADSGAGDEAPMSDLQAAE 382
+ QR +A L LQ E E A +V +AL A A E AE
Sbjct: 1533 REKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1591
Query: 383 KEAW--RLLAQEEAA---MDAGAQQNPQPSPEGSSVDKPTPQEV---------AFQLRSY 428
K A R L +E A + A++ Q E + +E+ A +LR
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651
Query: 429 VQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQ-----IQ 483
+ + +++SL + +E A R +A QA+ Q A LEK +
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEKQRQLAEGTA 1709
Query: 484 QDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWE----RAELQ 539
Q +AA + L L + ++++ LE A L+ A ++L E RAE++
Sbjct: 1710 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1769
Query: 540 AGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLT 599
A+ + +S E+ Q L A + G+ + + LA
Sbjct: 1770 VLLASKARAEEESRSTS---EKSKQRLEA--------EAGRFRELAEEAARLRALAEEAK 1818
Query: 600 RTLDL-QEQLQSLRRELEQVAQKGRARRSQSAELNRD---LCKAHSALVLAFRGAHRKQE 655
R L +E R E E+V + A ++ L + K A R +
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 656 EQRRKLEQQMALMEAQQAEEVAVL 679
QRR+LE+Q A +A E +A L
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQL 1902
Score = 39.3 bits (90), Expect = 0.013
Identities = 111/528 (21%), Positives = 196/528 (37%), Gaps = 49/528 (9%)
Query: 168 SCQREAARLAERNAWLRLALSSREDEL-VRTQASLEAIR-----AEKETLQKEVQELQDS 221
S ++ AA AE L S+ ED L + QA LEA R AE+E ++E +E
Sbjct: 1937 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1996
Query: 222 LLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSL 281
L E + ++ E +R + ++ A L R S+ Q+ L
Sbjct: 1997 SLAAE--------EEAARQRKAALEEVERLKAKVEE----ARRLRERAEQESARQL--QL 2042
Query: 282 PNQPLSPEMHIME-AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQ-REAEA 339
+ + E A ++ ++L+ + +VL +G E + EA
Sbjct: 2043 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2102
Query: 340 TALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAG 399
A A Q EEA R+ A ++A A E R A++EAA A
Sbjct: 2103 QAEREAAQSRRQVEEAERL-------KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2155
Query: 400 AQQNPQPSPEGSSVDKPTPQEVAFQ-LRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRA 458
A+Q + + + ++ A Q LR Q QE +L L E T +
Sbjct: 2156 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---------TDHQK 2206
Query: 459 EAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREA-AL 517
+ + + +A +++Q++++L + R + +L + E R L LR+
Sbjct: 2207 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2266
Query: 518 RALGPAHVLLLEQLRWERAEL-----QAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGG 572
+ ++Q+ E A L +A + E+ + + AV
Sbjct: 2267 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2326
Query: 573 TSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAEL 632
T + ++LAQE A L D ++ Q L E + + A R + E+
Sbjct: 2327 TR--LKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382
Query: 633 NRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
+ + + + R R +E+ +R +Q + E E+A E
Sbjct: 2383 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2430
Score = 31.2 bits (69), Expect = 3.4
Identities = 52/200 (26%), Positives = 88/200 (44%), Gaps = 18/200 (9%)
Query: 200 SLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSF 259
SLE E+ Q+ + EL+D L+LE C + ++ + E + E Q +
Sbjct: 975 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1034
Query: 260 SLAHPL---LRRLRSHSSTQILGSLPNQPLSP----EMHIMEAQMEQLRG----SIEKLK 308
+ L + RL S + ++L P +P E+ + ++EQ+R +EKLK
Sbjct: 1035 AEVEGLGKGVARL-SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1093
Query: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSG 368
+S V++G +G E L Q + EA A+ L E + + + L A EA
Sbjct: 1094 ----TISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQP 1148
Query: 369 AGDEAPMSDLQAAEKEAWRL 388
D A +L+ A++ RL
Sbjct: 1149 TFD-ALRDELRGAQEVGERL 1167
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 50.1 bits (118), Expect = 7e-06
Identities = 114/535 (21%), Positives = 197/535 (36%), Gaps = 53/535 (9%)
Query: 187 LSSREDELVRTQASLEAIRAEKETLQKE-VQELQDSLLRLEPCPHLSHNQAGGSGSGSSS 245
+ S + +++ L +E TL + ++ + ++L R+E L+ Q +
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 246 SEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIE 305
EA E Q + AH + + ++ + + + E ++AQ +Q R E
Sbjct: 1365 VEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1420
Query: 306 KLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREA 365
+L+ + A +Q + E + E E + L L+ +E
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR------------ 1468
Query: 366 DSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQL 425
GA E +A E EA + AQEEA Q+ + V+ + + +
Sbjct: 1469 -GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1527
Query: 426 RSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRL-------- 477
QR + +++ +E V RA VQ L T A L
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETAQRSAEAELQSKRASFA 1586
Query: 478 EKT-QIQQDLVAAREALADLMLRLQLVRREKRGLEL---REAALRALGPAHV-------- 525
EKT Q+++ L A+A L R + RR ++ E RE A R L +
Sbjct: 1587 EKTAQLERSLQEEHVAVAQL--REEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 526 -LLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGG-QVGR 583
L E++ +++ QA G EE Q + ++ Q+
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQLAE 1702
Query: 584 AWDPEKLA--QELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHS 641
++LA QEL T ++Q Q L EL ++ ++ A + EL +L K +
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762
Query: 642 ALVLAFRGAHRKQEEQRRKLEQQMALMEAQQ------AEEVAVLEATARALGKPR 690
+ + R +EE R E+ +EA+ AEE A L A A + R
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Score = 47.0 bits (110), Expect = 6e-05
Identities = 143/668 (21%), Positives = 244/668 (36%), Gaps = 133/668 (19%)
Query: 68 RTDKKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQTLQHTLS 127
R ++ + S R+L A E K +A A+Q KE ++ QTLQ S
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--------ELQQTLQQEQS 2074
Query: 128 SLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAG-SCQREAARLAER-NAWLRL 185
L+ + G +E + + E A +REAA+ + RL
Sbjct: 2075 VLD-----------------QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 186 ALSSREDELVRTQASLEAIRAEKETLQKEVQELQ--DSLLRLEPCPHLSHNQAGGSGSGS 243
S+ E R QA A + KE Q+ + Q + LR + + +
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 244 SSSEADREPW---------ETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIME 294
+A E ET +L L+RL++ ++ + + E+ +
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE---AARQRSQVEEELFSVR 2234
Query: 295 AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEAT--ALHLALQYSEHC 352
QME+L +++ NR L R + + + Q EAE A + S
Sbjct: 2235 VQMEELSKLKARIEAENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 353 EEAYRVLLALRE--ADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEG 410
+EA R+ E A A E + + A +EA RL A+ E QQ + + E
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL-----QQQKELAQEQ 2342
Query: 411 SSVDKPTPQEVAFQLRSYVQRLQ-----ERRSLMKILSEPGPTLAPMPTVPRAEAMVQ-- 463
+ + +++A QL Q Q ER+ +++ +E + + RA+A +
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2402
Query: 464 -----------------AILGTQAGPALPRLEKTQIQQ---DLVAAREALADLMLRLQLV 503
L TQ L + + Q QQ D REA+A+L + +
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462
Query: 504 RREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWY 563
++E + L+L+ ++ + EQL E LQ + S E +
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQ------EQLLQETQALQQSFLSEKD-------SLLQRERFI 2509
Query: 564 QGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGR 623
+ A KL Q + + L+E+ Q ++++EQ Q+
Sbjct: 2510 EQEKA--------------------KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 624 ARRSQSAELNRDLCKAHSALVLAFRGAHRKQEE------QRRKLEQQMALMEAQQAEEVA 677
A ++ + A G RKQEE QRR+ E+ +A + E++
Sbjct: 2550 ASMEEARRRQHE----------AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 678 VLEATARA 685
+LE RA
Sbjct: 2600 LLEEQHRA 2607
Score = 45.8 bits (107), Expect = 1e-04
Identities = 123/564 (21%), Positives = 211/564 (37%), Gaps = 76/564 (13%)
Query: 159 SLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQEL 218
+L KQ +A AER A + ++E+VR + + + +K ++Q+E+Q+L
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 219 QDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQIL 278
+ S ++A + A+R ++ + RL+ ++ +
Sbjct: 1426 RQS------------SEAEIQAKARQAEAAERSRLRIEEEIRVV-----RLQLEATERQR 1468
Query: 279 GSLPN--QPLSPEMHIMEAQMEQLRGSIEKLK------CFNRLLSAVLQGYKGRCEGLSM 330
G Q L EAQ Q + E+L+ + + V + + E +
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 331 QLGQREAEATALHLALQYSE--------HCEEAYRVLLALREADSGAGDEAPMSDLQAAE 382
+ QR +A L LQ E E A +V +AL A A E AE
Sbjct: 1529 REKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 383 KEAW--RLLAQEEAA---MDAGAQQNPQPSPEGSSVDKPTPQEV---------AFQLRSY 428
K A R L +E A + A++ Q E + +E+ A +LR
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 429 VQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQ-----IQ 483
+ + +++SL + +E A R +A QA+ Q A LEK +
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEKQRQLAEGTA 1705
Query: 484 QDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWE----RAELQ 539
Q +AA + L L + ++++ LE A L+ A ++L E RAE++
Sbjct: 1706 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 540 AGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLT 599
A+ + +S E+ Q L A + G+ + + LA
Sbjct: 1766 VLLASKARAEEESRSTS---EKSKQRLEA--------EAGRFRELAEEAARLRALAEEAK 1814
Query: 600 RTLDL-QEQLQSLRRELEQVAQKGRARRSQSAELNRD---LCKAHSALVLAFRGAHRKQE 655
R L +E R E E+V + A ++ L + K A R +
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 656 EQRRKLEQQMALMEAQQAEEVAVL 679
QRR+LE+Q A +A E +A L
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQL 1898
Score = 39.3 bits (90), Expect = 0.013
Identities = 111/528 (21%), Positives = 196/528 (37%), Gaps = 49/528 (9%)
Query: 168 SCQREAARLAERNAWLRLALSSREDEL-VRTQASLEAIR-----AEKETLQKEVQELQDS 221
S ++ AA AE L S+ ED L + QA LEA R AE+E ++E +E
Sbjct: 1933 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 222 LLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSL 281
L E + ++ E +R + ++ A L R S+ Q+ L
Sbjct: 1993 SLAAE--------EEAARQRKAALEEVERLKAKVEE----ARRLRERAEQESARQL--QL 2038
Query: 282 PNQPLSPEMHIME-AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQ-REAEA 339
+ + E A ++ ++L+ + +VL +G E + EA
Sbjct: 2039 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098
Query: 340 TALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAG 399
A A Q EEA R+ A ++A A E R A++EAA A
Sbjct: 2099 QAEREAAQSRRQVEEAERL-------KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2151
Query: 400 AQQNPQPSPEGSSVDKPTPQEVAFQ-LRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRA 458
A+Q + + + ++ A Q LR Q QE +L L E T +
Sbjct: 2152 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---------TDHQK 2202
Query: 459 EAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREA-AL 517
+ + + +A +++Q++++L + R + +L + E R L LR+
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 518 RALGPAHVLLLEQLRWERAEL-----QAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGG 572
+ ++Q+ E A L +A + E+ + + AV
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 573 TSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAEL 632
T + ++LAQE A L D ++ Q L E + + A R + E+
Sbjct: 2323 TR--LKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 633 NRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
+ + + + R R +E+ +R +Q + E E+A E
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Score = 31.2 bits (69), Expect = 3.4
Identities = 52/200 (26%), Positives = 88/200 (44%), Gaps = 18/200 (9%)
Query: 200 SLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSF 259
SLE E+ Q+ + EL+D L+LE C + ++ + E + E Q +
Sbjct: 971 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1030
Query: 260 SLAHPL---LRRLRSHSSTQILGSLPNQPLSP----EMHIMEAQMEQLRG----SIEKLK 308
+ L + RL S + ++L P +P E+ + ++EQ+R +EKLK
Sbjct: 1031 AEVEGLGKGVARL-SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1089
Query: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSG 368
+S V++G +G E L Q + EA A+ L E + + + L A EA
Sbjct: 1090 ----TISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQP 1144
Query: 369 AGDEAPMSDLQAAEKEAWRL 388
D A +L+ A++ RL
Sbjct: 1145 TFD-ALRDELRGAQEVGERL 1163
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 50.1 bits (118), Expect = 7e-06
Identities = 114/535 (21%), Positives = 197/535 (36%), Gaps = 53/535 (9%)
Query: 187 LSSREDELVRTQASLEAIRAEKETLQKE-VQELQDSLLRLEPCPHLSHNQAGGSGSGSSS 245
+ S + +++ L +E TL + ++ + ++L R+E L+ Q +
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1332
Query: 246 SEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIE 305
EA E Q + AH + + ++ + + + E ++AQ +Q R E
Sbjct: 1333 VEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1388
Query: 306 KLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREA 365
+L+ + A +Q + E + E E + L L+ +E
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR------------ 1436
Query: 366 DSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQL 425
GA E +A E EA + AQEEA Q+ + V+ + + +
Sbjct: 1437 -GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1495
Query: 426 RSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRL-------- 477
QR + +++ +E V RA VQ L T A L
Sbjct: 1496 AREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETAQRSAEAELQSKRASFA 1554
Query: 478 EKT-QIQQDLVAAREALADLMLRLQLVRREKRGLEL---REAALRALGPAHV-------- 525
EKT Q+++ L A+A L R + RR ++ E RE A R L +
Sbjct: 1555 EKTAQLERSLQEEHVAVAQL--REEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1612
Query: 526 -LLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGG-QVGR 583
L E++ +++ QA G EE Q + ++ Q+
Sbjct: 1613 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQLAE 1670
Query: 584 AWDPEKLA--QELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHS 641
++LA QEL T ++Q Q L EL ++ ++ A + EL +L K +
Sbjct: 1671 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1730
Query: 642 ALVLAFRGAHRKQEEQRRKLEQQMALMEAQQ------AEEVAVLEATARALGKPR 690
+ + R +EE R E+ +EA+ AEE A L A A + R
Sbjct: 1731 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785
Score = 47.0 bits (110), Expect = 6e-05
Identities = 143/668 (21%), Positives = 244/668 (36%), Gaps = 133/668 (19%)
Query: 68 RTDKKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQTLQHTLS 127
R ++ + S R+L A E K +A A+Q KE ++ QTLQ S
Sbjct: 1991 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--------ELQQTLQQEQS 2042
Query: 128 SLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAG-SCQREAARLAER-NAWLRL 185
L+ + G +E + + E A +REAA+ + RL
Sbjct: 2043 VLD-----------------QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2085
Query: 186 ALSSREDELVRTQASLEAIRAEKETLQKEVQELQ--DSLLRLEPCPHLSHNQAGGSGSGS 243
S+ E R QA A + KE Q+ + Q + LR + + +
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2145
Query: 244 SSSEADREPW---------ETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIME 294
+A E ET +L L+RL++ ++ + + E+ +
Sbjct: 2146 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE---AARQRSQVEEELFSVR 2202
Query: 295 AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEAT--ALHLALQYSEHC 352
QME+L +++ NR L R + + + Q EAE A + S
Sbjct: 2203 VQMEELSKLKARIEAENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255
Query: 353 EEAYRVLLALRE--ADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEG 410
+EA R+ E A A E + + A +EA RL A+ E QQ + + E
Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL-----QQQKELAQEQ 2310
Query: 411 SSVDKPTPQEVAFQLRSYVQRLQ-----ERRSLMKILSEPGPTLAPMPTVPRAEAMVQ-- 463
+ + +++A QL Q Q ER+ +++ +E + + RA+A +
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2370
Query: 464 -----------------AILGTQAGPALPRLEKTQIQQ---DLVAAREALADLMLRLQLV 503
L TQ L + + Q QQ D REA+A+L + +
Sbjct: 2371 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2430
Query: 504 RREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWY 563
++E + L+L+ ++ + EQL E LQ + S E +
Sbjct: 2431 QQEAKLLQLKSEEMQTVQQ------EQLLQETQALQQSFLSEKD-------SLLQRERFI 2477
Query: 564 QGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGR 623
+ A KL Q + + L+E+ Q ++++EQ Q+
Sbjct: 2478 EQEKA--------------------KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517
Query: 624 ARRSQSAELNRDLCKAHSALVLAFRGAHRKQEE------QRRKLEQQMALMEAQQAEEVA 677
A ++ + A G RKQEE QRR+ E+ +A + E++
Sbjct: 2518 ASMEEARRRQHE----------AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567
Query: 678 VLEATARA 685
+LE RA
Sbjct: 2568 LLEEQHRA 2575
Score = 45.8 bits (107), Expect = 1e-04
Identities = 123/564 (21%), Positives = 211/564 (37%), Gaps = 76/564 (13%)
Query: 159 SLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQEL 218
+L KQ +A AER A + ++E+VR + + + +K ++Q+E+Q+L
Sbjct: 1336 ALEKQRQLAEAHAQAKAQAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393
Query: 219 QDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQIL 278
+ S ++A + A+R ++ + RL+ ++ +
Sbjct: 1394 RQS------------SEAEIQAKARQAEAAERSRLRIEEEIRVV-----RLQLEATERQR 1436
Query: 279 GSLPN--QPLSPEMHIMEAQMEQLRGSIEKLK------CFNRLLSAVLQGYKGRCEGLSM 330
G Q L EAQ Q + E+L+ + + V + + E +
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496
Query: 331 QLGQREAEATALHLALQYSE--------HCEEAYRVLLALREADSGAGDEAPMSDLQAAE 382
+ QR +A L LQ E E A +V +AL A A E AE
Sbjct: 1497 REKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1555
Query: 383 KEAW--RLLAQEEAA---MDAGAQQNPQPSPEGSSVDKPTPQEV---------AFQLRSY 428
K A R L +E A + A++ Q E + +E+ A +LR
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615
Query: 429 VQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQ-----IQ 483
+ + +++SL + +E A R +A QA+ Q A LEK +
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEKQRQLAEGTA 1673
Query: 484 QDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWE----RAELQ 539
Q +AA + L L + ++++ LE A L+ A ++L E RAE++
Sbjct: 1674 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1733
Query: 540 AGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLT 599
A+ + +S E+ Q L A + G+ + + LA
Sbjct: 1734 VLLASKARAEEESRSTS---EKSKQRLEA--------EAGRFRELAEEAARLRALAEEAK 1782
Query: 600 RTLDL-QEQLQSLRRELEQVAQKGRARRSQSAELNRD---LCKAHSALVLAFRGAHRKQE 655
R L +E R E E+V + A ++ L + K A R +
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 656 EQRRKLEQQMALMEAQQAEEVAVL 679
QRR+LE+Q A +A E +A L
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQL 1866
Score = 39.3 bits (90), Expect = 0.013
Identities = 111/528 (21%), Positives = 196/528 (37%), Gaps = 49/528 (9%)
Query: 168 SCQREAARLAERNAWLRLALSSREDEL-VRTQASLEAIR-----AEKETLQKEVQELQDS 221
S ++ AA AE L S+ ED L + QA LEA R AE+E ++E +E
Sbjct: 1901 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1960
Query: 222 LLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSL 281
L E + ++ E +R + ++ A L R S+ Q+ L
Sbjct: 1961 SLAAE--------EEAARQRKAALEEVERLKAKVEE----ARRLRERAEQESARQL--QL 2006
Query: 282 PNQPLSPEMHIME-AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQ-REAEA 339
+ + E A ++ ++L+ + +VL +G E + EA
Sbjct: 2007 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2066
Query: 340 TALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAG 399
A A Q EEA R+ A ++A A E R A++EAA A
Sbjct: 2067 QAEREAAQSRRQVEEAERL-------KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2119
Query: 400 AQQNPQPSPEGSSVDKPTPQEVAFQ-LRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRA 458
A+Q + + + ++ A Q LR Q QE +L L E T +
Sbjct: 2120 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---------TDHQK 2170
Query: 459 EAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREA-AL 517
+ + + +A +++Q++++L + R + +L + E R L LR+
Sbjct: 2171 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2230
Query: 518 RALGPAHVLLLEQLRWERAEL-----QAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGG 572
+ ++Q+ E A L +A + E+ + + AV
Sbjct: 2231 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2290
Query: 573 TSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAEL 632
T + ++LAQE A L D ++ Q L E + + A R + E+
Sbjct: 2291 TR--LKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346
Query: 633 NRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
+ + + + R R +E+ +R +Q + E E+A E
Sbjct: 2347 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2394
Score = 31.2 bits (69), Expect = 3.4
Identities = 52/200 (26%), Positives = 88/200 (44%), Gaps = 18/200 (9%)
Query: 200 SLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSF 259
SLE E+ Q+ + EL+D L+LE C + ++ + E + E Q +
Sbjct: 939 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 998
Query: 260 SLAHPL---LRRLRSHSSTQILGSLPNQPLSP----EMHIMEAQMEQLRG----SIEKLK 308
+ L + RL S + ++L P +P E+ + ++EQ+R +EKLK
Sbjct: 999 AEVEGLGKGVARL-SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1057
Query: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSG 368
+S V++G +G E L Q + EA A+ L E + + + L A EA
Sbjct: 1058 ----TISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQP 1112
Query: 369 AGDEAPMSDLQAAEKEAWRL 388
D A +L+ A++ RL
Sbjct: 1113 TFD-ALRDELRGAQEVGERL 1131
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 50.1 bits (118), Expect = 7e-06
Identities = 114/535 (21%), Positives = 197/535 (36%), Gaps = 53/535 (9%)
Query: 187 LSSREDELVRTQASLEAIRAEKETLQKE-VQELQDSLLRLEPCPHLSHNQAGGSGSGSSS 245
+ S + +++ L +E TL + ++ + ++L R+E L+ Q +
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1501
Query: 246 SEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIE 305
EA E Q + AH + + ++ + + + E ++AQ +Q R E
Sbjct: 1502 VEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1557
Query: 306 KLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREA 365
+L+ + A +Q + E + E E + L L+ +E
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR------------ 1605
Query: 366 DSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQL 425
GA E +A E EA + AQEEA Q+ + V+ + + +
Sbjct: 1606 -GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1664
Query: 426 RSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRL-------- 477
QR + +++ +E V RA VQ L T A L
Sbjct: 1665 AREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETAQRSAEAELQSKRASFA 1723
Query: 478 EKT-QIQQDLVAAREALADLMLRLQLVRREKRGLEL---REAALRALGPAHV-------- 525
EKT Q+++ L A+A L R + RR ++ E RE A R L +
Sbjct: 1724 EKTAQLERSLQEEHVAVAQL--REEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1781
Query: 526 -LLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGG-QVGR 583
L E++ +++ QA G EE Q + ++ Q+
Sbjct: 1782 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQLAE 1839
Query: 584 AWDPEKLA--QELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHS 641
++LA QEL T ++Q Q L EL ++ ++ A + EL +L K +
Sbjct: 1840 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1899
Query: 642 ALVLAFRGAHRKQEEQRRKLEQQMALMEAQQ------AEEVAVLEATARALGKPR 690
+ + R +EE R E+ +EA+ AEE A L A A + R
Sbjct: 1900 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954
Score = 47.0 bits (110), Expect = 6e-05
Identities = 143/668 (21%), Positives = 244/668 (36%), Gaps = 133/668 (19%)
Query: 68 RTDKKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQTLQHTLS 127
R ++ + S R+L A E K +A A+Q KE ++ QTLQ S
Sbjct: 2160 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--------ELQQTLQQEQS 2211
Query: 128 SLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAG-SCQREAARLAER-NAWLRL 185
L+ + G +E + + E A +REAA+ + RL
Sbjct: 2212 VLD-----------------QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2254
Query: 186 ALSSREDELVRTQASLEAIRAEKETLQKEVQELQ--DSLLRLEPCPHLSHNQAGGSGSGS 243
S+ E R QA A + KE Q+ + Q + LR + + +
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2314
Query: 244 SSSEADREPW---------ETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIME 294
+A E ET +L L+RL++ ++ + + E+ +
Sbjct: 2315 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE---AARQRSQVEEELFSVR 2371
Query: 295 AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEAT--ALHLALQYSEHC 352
QME+L +++ NR L R + + + Q EAE A + S
Sbjct: 2372 VQMEELSKLKARIEAENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2424
Query: 353 EEAYRVLLALRE--ADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEG 410
+EA R+ E A A E + + A +EA RL A+ E QQ + + E
Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL-----QQQKELAQEQ 2479
Query: 411 SSVDKPTPQEVAFQLRSYVQRLQ-----ERRSLMKILSEPGPTLAPMPTVPRAEAMVQ-- 463
+ + +++A QL Q Q ER+ +++ +E + + RA+A +
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2539
Query: 464 -----------------AILGTQAGPALPRLEKTQIQQ---DLVAAREALADLMLRLQLV 503
L TQ L + + Q QQ D REA+A+L + +
Sbjct: 2540 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2599
Query: 504 RREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWY 563
++E + L+L+ ++ + EQL E LQ + S E +
Sbjct: 2600 QQEAKLLQLKSEEMQTVQQ------EQLLQETQALQQSFLSEKD-------SLLQRERFI 2646
Query: 564 QGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGR 623
+ A KL Q + + L+E+ Q ++++EQ Q+
Sbjct: 2647 EQEKA--------------------KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686
Query: 624 ARRSQSAELNRDLCKAHSALVLAFRGAHRKQEE------QRRKLEQQMALMEAQQAEEVA 677
A ++ + A G RKQEE QRR+ E+ +A + E++
Sbjct: 2687 ASMEEARRRQHE----------AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736
Query: 678 VLEATARA 685
+LE RA
Sbjct: 2737 LLEEQHRA 2744
Score = 45.8 bits (107), Expect = 1e-04
Identities = 123/564 (21%), Positives = 211/564 (37%), Gaps = 76/564 (13%)
Query: 159 SLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQEL 218
+L KQ +A AER A + ++E+VR + + + +K ++Q+E+Q+L
Sbjct: 1505 ALEKQRQLAEAHAQAKAQAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562
Query: 219 QDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQIL 278
+ S ++A + A+R ++ + RL+ ++ +
Sbjct: 1563 RQS------------SEAEIQAKARQAEAAERSRLRIEEEIRVV-----RLQLEATERQR 1605
Query: 279 GSLPN--QPLSPEMHIMEAQMEQLRGSIEKLK------CFNRLLSAVLQGYKGRCEGLSM 330
G Q L EAQ Q + E+L+ + + V + + E +
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665
Query: 331 QLGQREAEATALHLALQYSE--------HCEEAYRVLLALREADSGAGDEAPMSDLQAAE 382
+ QR +A L LQ E E A +V +AL A A E AE
Sbjct: 1666 REKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1724
Query: 383 KEAW--RLLAQEEAA---MDAGAQQNPQPSPEGSSVDKPTPQEV---------AFQLRSY 428
K A R L +E A + A++ Q E + +E+ A +LR
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784
Query: 429 VQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQ-----IQ 483
+ + +++SL + +E A R +A QA+ Q A LEK +
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEKQRQLAEGTA 1842
Query: 484 QDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWE----RAELQ 539
Q +AA + L L + ++++ LE A L+ A ++L E RAE++
Sbjct: 1843 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1902
Query: 540 AGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLT 599
A+ + +S E+ Q L A + G+ + + LA
Sbjct: 1903 VLLASKARAEEESRSTS---EKSKQRLEA--------EAGRFRELAEEAARLRALAEEAK 1951
Query: 600 RTLDL-QEQLQSLRRELEQVAQKGRARRSQSAELNRD---LCKAHSALVLAFRGAHRKQE 655
R L +E R E E+V + A ++ L + K A R +
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 656 EQRRKLEQQMALMEAQQAEEVAVL 679
QRR+LE+Q A +A E +A L
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQL 2035
Score = 39.3 bits (90), Expect = 0.013
Identities = 111/528 (21%), Positives = 196/528 (37%), Gaps = 49/528 (9%)
Query: 168 SCQREAARLAERNAWLRLALSSREDEL-VRTQASLEAIR-----AEKETLQKEVQELQDS 221
S ++ AA AE L S+ ED L + QA LEA R AE+E ++E +E
Sbjct: 2070 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2129
Query: 222 LLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSL 281
L E + ++ E +R + ++ A L R S+ Q+ L
Sbjct: 2130 SLAAE--------EEAARQRKAALEEVERLKAKVEE----ARRLRERAEQESARQL--QL 2175
Query: 282 PNQPLSPEMHIME-AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQ-REAEA 339
+ + E A ++ ++L+ + +VL +G E + EA
Sbjct: 2176 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2235
Query: 340 TALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAG 399
A A Q EEA R+ A ++A A E R A++EAA A
Sbjct: 2236 QAEREAAQSRRQVEEAERL-------KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2288
Query: 400 AQQNPQPSPEGSSVDKPTPQEVAFQ-LRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRA 458
A+Q + + + ++ A Q LR Q QE +L L E T +
Sbjct: 2289 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---------TDHQK 2339
Query: 459 EAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREA-AL 517
+ + + +A +++Q++++L + R + +L + E R L LR+
Sbjct: 2340 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2399
Query: 518 RALGPAHVLLLEQLRWERAEL-----QAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGG 572
+ ++Q+ E A L +A + E+ + + AV
Sbjct: 2400 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2459
Query: 573 TSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAEL 632
T + ++LAQE A L D ++ Q L E + + A R + E+
Sbjct: 2460 TR--LKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515
Query: 633 NRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
+ + + + R R +E+ +R +Q + E E+A E
Sbjct: 2516 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2563
Score = 31.2 bits (69), Expect = 3.4
Identities = 52/200 (26%), Positives = 88/200 (44%), Gaps = 18/200 (9%)
Query: 200 SLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSF 259
SLE E+ Q+ + EL+D L+LE C + ++ + E + E Q +
Sbjct: 1108 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1167
Query: 260 SLAHPL---LRRLRSHSSTQILGSLPNQPLSP----EMHIMEAQMEQLRG----SIEKLK 308
+ L + RL S + ++L P +P E+ + ++EQ+R +EKLK
Sbjct: 1168 AEVEGLGKGVARL-SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1226
Query: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSG 368
+S V++G +G E L Q + EA A+ L E + + + L A EA
Sbjct: 1227 ----TISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQP 1281
Query: 369 AGDEAPMSDLQAAEKEAWRL 388
D A +L+ A++ RL
Sbjct: 1282 TFD-ALRDELRGAQEVGERL 1300
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 50.1 bits (118), Expect = 7e-06
Identities = 114/535 (21%), Positives = 197/535 (36%), Gaps = 53/535 (9%)
Query: 187 LSSREDELVRTQASLEAIRAEKETLQKE-VQELQDSLLRLEPCPHLSHNQAGGSGSGSSS 245
+ S + +++ L +E TL + ++ + ++L R+E L+ Q +
Sbjct: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1342
Query: 246 SEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIE 305
EA E Q + AH + + ++ + + + E ++AQ +Q R E
Sbjct: 1343 VEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1398
Query: 306 KLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREA 365
+L+ + A +Q + E + E E + L L+ +E
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR------------ 1446
Query: 366 DSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQL 425
GA E +A E EA + AQEEA Q+ + V+ + + +
Sbjct: 1447 -GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1505
Query: 426 RSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRL-------- 477
QR + +++ +E V RA VQ L T A L
Sbjct: 1506 AREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETAQRSAEAELQSKRASFA 1564
Query: 478 EKT-QIQQDLVAAREALADLMLRLQLVRREKRGLEL---REAALRALGPAHV-------- 525
EKT Q+++ L A+A L R + RR ++ E RE A R L +
Sbjct: 1565 EKTAQLERSLQEEHVAVAQL--REEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1622
Query: 526 -LLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGG-QVGR 583
L E++ +++ QA G EE Q + ++ Q+
Sbjct: 1623 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQLAE 1680
Query: 584 AWDPEKLA--QELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHS 641
++LA QEL T ++Q Q L EL ++ ++ A + EL +L K +
Sbjct: 1681 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1740
Query: 642 ALVLAFRGAHRKQEEQRRKLEQQMALMEAQQ------AEEVAVLEATARALGKPR 690
+ + R +EE R E+ +EA+ AEE A L A A + R
Sbjct: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795
Score = 47.0 bits (110), Expect = 6e-05
Identities = 143/668 (21%), Positives = 244/668 (36%), Gaps = 133/668 (19%)
Query: 68 RTDKKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQTLQHTLS 127
R ++ + S R+L A E K +A A+Q KE ++ QTLQ S
Sbjct: 2001 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--------ELQQTLQQEQS 2052
Query: 128 SLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAG-SCQREAARLAER-NAWLRL 185
L+ + G +E + + E A +REAA+ + RL
Sbjct: 2053 VLD-----------------QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2095
Query: 186 ALSSREDELVRTQASLEAIRAEKETLQKEVQELQ--DSLLRLEPCPHLSHNQAGGSGSGS 243
S+ E R QA A + KE Q+ + Q + LR + + +
Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2155
Query: 244 SSSEADREPW---------ETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIME 294
+A E ET +L L+RL++ ++ + + E+ +
Sbjct: 2156 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE---AARQRSQVEEELFSVR 2212
Query: 295 AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEAT--ALHLALQYSEHC 352
QME+L +++ NR L R + + + Q EAE A + S
Sbjct: 2213 VQMEELSKLKARIEAENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2265
Query: 353 EEAYRVLLALRE--ADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEG 410
+EA R+ E A A E + + A +EA RL A+ E QQ + + E
Sbjct: 2266 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL-----QQQKELAQEQ 2320
Query: 411 SSVDKPTPQEVAFQLRSYVQRLQ-----ERRSLMKILSEPGPTLAPMPTVPRAEAMVQ-- 463
+ + +++A QL Q Q ER+ +++ +E + + RA+A +
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2380
Query: 464 -----------------AILGTQAGPALPRLEKTQIQQ---DLVAAREALADLMLRLQLV 503
L TQ L + + Q QQ D REA+A+L + +
Sbjct: 2381 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2440
Query: 504 RREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWY 563
++E + L+L+ ++ + EQL E LQ + S E +
Sbjct: 2441 QQEAKLLQLKSEEMQTVQQ------EQLLQETQALQQSFLSEKD-------SLLQRERFI 2487
Query: 564 QGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGR 623
+ A KL Q + + L+E+ Q ++++EQ Q+
Sbjct: 2488 EQEKA--------------------KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527
Query: 624 ARRSQSAELNRDLCKAHSALVLAFRGAHRKQEE------QRRKLEQQMALMEAQQAEEVA 677
A ++ + A G RKQEE QRR+ E+ +A + E++
Sbjct: 2528 ASMEEARRRQHE----------AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577
Query: 678 VLEATARA 685
+LE RA
Sbjct: 2578 LLEEQHRA 2585
Score = 45.8 bits (107), Expect = 1e-04
Identities = 123/564 (21%), Positives = 211/564 (37%), Gaps = 76/564 (13%)
Query: 159 SLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQEL 218
+L KQ +A AER A + ++E+VR + + + +K ++Q+E+Q+L
Sbjct: 1346 ALEKQRQLAEAHAQAKAQAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
Query: 219 QDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQIL 278
+ S ++A + A+R ++ + RL+ ++ +
Sbjct: 1404 RQS------------SEAEIQAKARQAEAAERSRLRIEEEIRVV-----RLQLEATERQR 1446
Query: 279 GSLPN--QPLSPEMHIMEAQMEQLRGSIEKLK------CFNRLLSAVLQGYKGRCEGLSM 330
G Q L EAQ Q + E+L+ + + V + + E +
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506
Query: 331 QLGQREAEATALHLALQYSE--------HCEEAYRVLLALREADSGAGDEAPMSDLQAAE 382
+ QR +A L LQ E E A +V +AL A A E AE
Sbjct: 1507 REKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1565
Query: 383 KEAW--RLLAQEEAA---MDAGAQQNPQPSPEGSSVDKPTPQEV---------AFQLRSY 428
K A R L +E A + A++ Q E + +E+ A +LR
Sbjct: 1566 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625
Query: 429 VQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQ-----IQ 483
+ + +++SL + +E A R +A QA+ Q A LEK +
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEKQRQLAEGTA 1683
Query: 484 QDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWE----RAELQ 539
Q +AA + L L + ++++ LE A L+ A ++L E RAE++
Sbjct: 1684 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1743
Query: 540 AGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLT 599
A+ + +S E+ Q L A + G+ + + LA
Sbjct: 1744 VLLASKARAEEESRSTS---EKSKQRLEA--------EAGRFRELAEEAARLRALAEEAK 1792
Query: 600 RTLDL-QEQLQSLRRELEQVAQKGRARRSQSAELNRD---LCKAHSALVLAFRGAHRKQE 655
R L +E R E E+V + A ++ L + K A R +
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 656 EQRRKLEQQMALMEAQQAEEVAVL 679
QRR+LE+Q A +A E +A L
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQL 1876
Score = 39.3 bits (90), Expect = 0.013
Identities = 111/528 (21%), Positives = 196/528 (37%), Gaps = 49/528 (9%)
Query: 168 SCQREAARLAERNAWLRLALSSREDEL-VRTQASLEAIR-----AEKETLQKEVQELQDS 221
S ++ AA AE L S+ ED L + QA LEA R AE+E ++E +E
Sbjct: 1911 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1970
Query: 222 LLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSL 281
L E + ++ E +R + ++ A L R S+ Q+ L
Sbjct: 1971 SLAAE--------EEAARQRKAALEEVERLKAKVEE----ARRLRERAEQESARQL--QL 2016
Query: 282 PNQPLSPEMHIME-AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQ-REAEA 339
+ + E A ++ ++L+ + +VL +G E + EA
Sbjct: 2017 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2076
Query: 340 TALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAG 399
A A Q EEA R+ A ++A A E R A++EAA A
Sbjct: 2077 QAEREAAQSRRQVEEAERL-------KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2129
Query: 400 AQQNPQPSPEGSSVDKPTPQEVAFQ-LRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRA 458
A+Q + + + ++ A Q LR Q QE +L L E T +
Sbjct: 2130 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---------TDHQK 2180
Query: 459 EAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREA-AL 517
+ + + +A +++Q++++L + R + +L + E R L LR+
Sbjct: 2181 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2240
Query: 518 RALGPAHVLLLEQLRWERAEL-----QAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGG 572
+ ++Q+ E A L +A + E+ + + AV
Sbjct: 2241 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2300
Query: 573 TSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAEL 632
T + ++LAQE A L D ++ Q L E + + A R + E+
Sbjct: 2301 TR--LKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356
Query: 633 NRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
+ + + + R R +E+ +R +Q + E E+A E
Sbjct: 2357 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2404
Score = 31.2 bits (69), Expect = 3.4
Identities = 52/200 (26%), Positives = 88/200 (44%), Gaps = 18/200 (9%)
Query: 200 SLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSF 259
SLE E+ Q+ + EL+D L+LE C + ++ + E + E Q +
Sbjct: 949 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1008
Query: 260 SLAHPL---LRRLRSHSSTQILGSLPNQPLSP----EMHIMEAQMEQLRG----SIEKLK 308
+ L + RL S + ++L P +P E+ + ++EQ+R +EKLK
Sbjct: 1009 AEVEGLGKGVARL-SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1067
Query: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSG 368
+S V++G +G E L Q + EA A+ L E + + + L A EA
Sbjct: 1068 ----TISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQP 1122
Query: 369 AGDEAPMSDLQAAEKEAWRL 388
D A +L+ A++ RL
Sbjct: 1123 TFD-ALRDELRGAQEVGERL 1141
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 50.1 bits (118), Expect = 7e-06
Identities = 114/535 (21%), Positives = 197/535 (36%), Gaps = 53/535 (9%)
Query: 187 LSSREDELVRTQASLEAIRAEKETLQKE-VQELQDSLLRLEPCPHLSHNQAGGSGSGSSS 245
+ S + +++ L +E TL + ++ + ++L R+E L+ Q +
Sbjct: 1291 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1350
Query: 246 SEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIE 305
EA E Q + AH + + ++ + + + E ++AQ +Q R E
Sbjct: 1351 VEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1406
Query: 306 KLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREA 365
+L+ + A +Q + E + E E + L L+ +E
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR------------ 1454
Query: 366 DSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQL 425
GA E +A E EA + AQEEA Q+ + V+ + + +
Sbjct: 1455 -GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1513
Query: 426 RSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRL-------- 477
QR + +++ +E V RA VQ L T A L
Sbjct: 1514 AREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETAQRSAEAELQSKRASFA 1572
Query: 478 EKT-QIQQDLVAAREALADLMLRLQLVRREKRGLEL---REAALRALGPAHV-------- 525
EKT Q+++ L A+A L R + RR ++ E RE A R L +
Sbjct: 1573 EKTAQLERSLQEEHVAVAQL--REEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1630
Query: 526 -LLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGG-QVGR 583
L E++ +++ QA G EE Q + ++ Q+
Sbjct: 1631 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQLAE 1688
Query: 584 AWDPEKLA--QELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHS 641
++LA QEL T ++Q Q L EL ++ ++ A + EL +L K +
Sbjct: 1689 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1748
Query: 642 ALVLAFRGAHRKQEEQRRKLEQQMALMEAQQ------AEEVAVLEATARALGKPR 690
+ + R +EE R E+ +EA+ AEE A L A A + R
Sbjct: 1749 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1803
Score = 47.0 bits (110), Expect = 6e-05
Identities = 143/668 (21%), Positives = 244/668 (36%), Gaps = 133/668 (19%)
Query: 68 RTDKKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQTLQHTLS 127
R ++ + S R+L A E K +A A+Q KE ++ QTLQ S
Sbjct: 2009 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--------ELQQTLQQEQS 2060
Query: 128 SLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAG-SCQREAARLAER-NAWLRL 185
L+ + G +E + + E A +REAA+ + RL
Sbjct: 2061 VLD-----------------QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2103
Query: 186 ALSSREDELVRTQASLEAIRAEKETLQKEVQELQ--DSLLRLEPCPHLSHNQAGGSGSGS 243
S+ E R QA A + KE Q+ + Q + LR + + +
Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2163
Query: 244 SSSEADREPW---------ETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIME 294
+A E ET +L L+RL++ ++ + + E+ +
Sbjct: 2164 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE---AARQRSQVEEELFSVR 2220
Query: 295 AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEAT--ALHLALQYSEHC 352
QME+L +++ NR L R + + + Q EAE A + S
Sbjct: 2221 VQMEELSKLKARIEAENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2273
Query: 353 EEAYRVLLALRE--ADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEG 410
+EA R+ E A A E + + A +EA RL A+ E QQ + + E
Sbjct: 2274 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL-----QQQKELAQEQ 2328
Query: 411 SSVDKPTPQEVAFQLRSYVQRLQ-----ERRSLMKILSEPGPTLAPMPTVPRAEAMVQ-- 463
+ + +++A QL Q Q ER+ +++ +E + + RA+A +
Sbjct: 2329 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2388
Query: 464 -----------------AILGTQAGPALPRLEKTQIQQ---DLVAAREALADLMLRLQLV 503
L TQ L + + Q QQ D REA+A+L + +
Sbjct: 2389 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2448
Query: 504 RREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWY 563
++E + L+L+ ++ + EQL E LQ + S E +
Sbjct: 2449 QQEAKLLQLKSEEMQTVQQ------EQLLQETQALQQSFLSEKD-------SLLQRERFI 2495
Query: 564 QGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGR 623
+ A KL Q + + L+E+ Q ++++EQ Q+
Sbjct: 2496 EQEKA--------------------KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535
Query: 624 ARRSQSAELNRDLCKAHSALVLAFRGAHRKQEE------QRRKLEQQMALMEAQQAEEVA 677
A ++ + A G RKQEE QRR+ E+ +A + E++
Sbjct: 2536 ASMEEARRRQHE----------AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585
Query: 678 VLEATARA 685
+LE RA
Sbjct: 2586 LLEEQHRA 2593
Score = 45.8 bits (107), Expect = 1e-04
Identities = 123/564 (21%), Positives = 211/564 (37%), Gaps = 76/564 (13%)
Query: 159 SLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQEL 218
+L KQ +A AER A + ++E+VR + + + +K ++Q+E+Q+L
Sbjct: 1354 ALEKQRQLAEAHAQAKAQAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411
Query: 219 QDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQIL 278
+ S ++A + A+R ++ + RL+ ++ +
Sbjct: 1412 RQS------------SEAEIQAKARQAEAAERSRLRIEEEIRVV-----RLQLEATERQR 1454
Query: 279 GSLPN--QPLSPEMHIMEAQMEQLRGSIEKLK------CFNRLLSAVLQGYKGRCEGLSM 330
G Q L EAQ Q + E+L+ + + V + + E +
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1514
Query: 331 QLGQREAEATALHLALQYSE--------HCEEAYRVLLALREADSGAGDEAPMSDLQAAE 382
+ QR +A L LQ E E A +V +AL A A E AE
Sbjct: 1515 REKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1573
Query: 383 KEAW--RLLAQEEAA---MDAGAQQNPQPSPEGSSVDKPTPQEV---------AFQLRSY 428
K A R L +E A + A++ Q E + +E+ A +LR
Sbjct: 1574 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633
Query: 429 VQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQ-----IQ 483
+ + +++SL + +E A R +A QA+ Q A LEK +
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEKQRQLAEGTA 1691
Query: 484 QDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWE----RAELQ 539
Q +AA + L L + ++++ LE A L+ A ++L E RAE++
Sbjct: 1692 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1751
Query: 540 AGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLT 599
A+ + +S E+ Q L A + G+ + + LA
Sbjct: 1752 VLLASKARAEEESRSTS---EKSKQRLEA--------EAGRFRELAEEAARLRALAEEAK 1800
Query: 600 RTLDL-QEQLQSLRRELEQVAQKGRARRSQSAELNRD---LCKAHSALVLAFRGAHRKQE 655
R L +E R E E+V + A ++ L + K A R +
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 656 EQRRKLEQQMALMEAQQAEEVAVL 679
QRR+LE+Q A +A E +A L
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQL 1884
Score = 39.3 bits (90), Expect = 0.013
Identities = 111/528 (21%), Positives = 196/528 (37%), Gaps = 49/528 (9%)
Query: 168 SCQREAARLAERNAWLRLALSSREDEL-VRTQASLEAIR-----AEKETLQKEVQELQDS 221
S ++ AA AE L S+ ED L + QA LEA R AE+E ++E +E
Sbjct: 1919 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1978
Query: 222 LLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSL 281
L E + ++ E +R + ++ A L R S+ Q+ L
Sbjct: 1979 SLAAE--------EEAARQRKAALEEVERLKAKVEE----ARRLRERAEQESARQL--QL 2024
Query: 282 PNQPLSPEMHIME-AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQ-REAEA 339
+ + E A ++ ++L+ + +VL +G E + EA
Sbjct: 2025 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2084
Query: 340 TALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAG 399
A A Q EEA R+ A ++A A E R A++EAA A
Sbjct: 2085 QAEREAAQSRRQVEEAERL-------KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2137
Query: 400 AQQNPQPSPEGSSVDKPTPQEVAFQ-LRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRA 458
A+Q + + + ++ A Q LR Q QE +L L E T +
Sbjct: 2138 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---------TDHQK 2188
Query: 459 EAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREA-AL 517
+ + + +A +++Q++++L + R + +L + E R L LR+
Sbjct: 2189 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2248
Query: 518 RALGPAHVLLLEQLRWERAEL-----QAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGG 572
+ ++Q+ E A L +A + E+ + + AV
Sbjct: 2249 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2308
Query: 573 TSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAEL 632
T + ++LAQE A L D ++ Q L E + + A R + E+
Sbjct: 2309 TR--LKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364
Query: 633 NRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
+ + + + R R +E+ +R +Q + E E+A E
Sbjct: 2365 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2412
Score = 31.2 bits (69), Expect = 3.4
Identities = 52/200 (26%), Positives = 88/200 (44%), Gaps = 18/200 (9%)
Query: 200 SLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSF 259
SLE E+ Q+ + EL+D L+LE C + ++ + E + E Q +
Sbjct: 957 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1016
Query: 260 SLAHPL---LRRLRSHSSTQILGSLPNQPLSP----EMHIMEAQMEQLRG----SIEKLK 308
+ L + RL S + ++L P +P E+ + ++EQ+R +EKLK
Sbjct: 1017 AEVEGLGKGVARL-SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1075
Query: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSG 368
+S V++G +G E L Q + EA A+ L E + + + L A EA
Sbjct: 1076 ----TISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQP 1130
Query: 369 AGDEAPMSDLQAAEKEAWRL 388
D A +L+ A++ RL
Sbjct: 1131 TFD-ALRDELRGAQEVGERL 1149
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 50.1 bits (118), Expect = 7e-06
Identities = 114/535 (21%), Positives = 197/535 (36%), Gaps = 53/535 (9%)
Query: 187 LSSREDELVRTQASLEAIRAEKETLQKE-VQELQDSLLRLEPCPHLSHNQAGGSGSGSSS 245
+ S + +++ L +E TL + ++ + ++L R+E L+ Q +
Sbjct: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1391
Query: 246 SEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIE 305
EA E Q + AH + + ++ + + + E ++AQ +Q R E
Sbjct: 1392 VEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1447
Query: 306 KLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREA 365
+L+ + A +Q + E + E E + L L+ +E
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR------------ 1495
Query: 366 DSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQL 425
GA E +A E EA + AQEEA Q+ + V+ + + +
Sbjct: 1496 -GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1554
Query: 426 RSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRL-------- 477
QR + +++ +E V RA VQ L T A L
Sbjct: 1555 AREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETAQRSAEAELQSKRASFA 1613
Query: 478 EKT-QIQQDLVAAREALADLMLRLQLVRREKRGLEL---REAALRALGPAHV-------- 525
EKT Q+++ L A+A L R + RR ++ E RE A R L +
Sbjct: 1614 EKTAQLERSLQEEHVAVAQL--REEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1671
Query: 526 -LLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGG-QVGR 583
L E++ +++ QA G EE Q + ++ Q+
Sbjct: 1672 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQLAE 1729
Query: 584 AWDPEKLA--QELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHS 641
++LA QEL T ++Q Q L EL ++ ++ A + EL +L K +
Sbjct: 1730 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1789
Query: 642 ALVLAFRGAHRKQEEQRRKLEQQMALMEAQQ------AEEVAVLEATARALGKPR 690
+ + R +EE R E+ +EA+ AEE A L A A + R
Sbjct: 1790 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844
Score = 47.0 bits (110), Expect = 6e-05
Identities = 143/668 (21%), Positives = 244/668 (36%), Gaps = 133/668 (19%)
Query: 68 RTDKKMDGGSGRELASAPEVPHKPAVEAHQAPEAALQYKETVPPGNGAPDVFQTLQHTLS 127
R ++ + S R+L A E K +A A+Q KE ++ QTLQ S
Sbjct: 2050 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--------ELQQTLQQEQS 2101
Query: 128 SLEAAAAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAG-SCQREAARLAER-NAWLRL 185
L+ + G +E + + E A +REAA+ + RL
Sbjct: 2102 VLD-----------------QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2144
Query: 186 ALSSREDELVRTQASLEAIRAEKETLQKEVQELQ--DSLLRLEPCPHLSHNQAGGSGSGS 243
S+ E R QA A + KE Q+ + Q + LR + + +
Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2204
Query: 244 SSSEADREPW---------ETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIME 294
+A E ET +L L+RL++ ++ + + E+ +
Sbjct: 2205 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE---AARQRSQVEEELFSVR 2261
Query: 295 AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEAT--ALHLALQYSEHC 352
QME+L +++ NR L R + + + Q EAE A + S
Sbjct: 2262 VQMEELSKLKARIEAENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2314
Query: 353 EEAYRVLLALRE--ADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEG 410
+EA R+ E A A E + + A +EA RL A+ E QQ + + E
Sbjct: 2315 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL-----QQQKELAQEQ 2369
Query: 411 SSVDKPTPQEVAFQLRSYVQRLQ-----ERRSLMKILSEPGPTLAPMPTVPRAEAMVQ-- 463
+ + +++A QL Q Q ER+ +++ +E + + RA+A +
Sbjct: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2429
Query: 464 -----------------AILGTQAGPALPRLEKTQIQQ---DLVAAREALADLMLRLQLV 503
L TQ L + + Q QQ D REA+A+L + +
Sbjct: 2430 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2489
Query: 504 RREKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWY 563
++E + L+L+ ++ + EQL E LQ + S E +
Sbjct: 2490 QQEAKLLQLKSEEMQTVQQ------EQLLQETQALQQSFLSEKD-------SLLQRERFI 2536
Query: 564 QGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGR 623
+ A KL Q + + L+E+ Q ++++EQ Q+
Sbjct: 2537 EQEKA--------------------KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576
Query: 624 ARRSQSAELNRDLCKAHSALVLAFRGAHRKQEE------QRRKLEQQMALMEAQQAEEVA 677
A ++ + A G RKQEE QRR+ E+ +A + E++
Sbjct: 2577 ASMEEARRRQHE----------AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626
Query: 678 VLEATARA 685
+LE RA
Sbjct: 2627 LLEEQHRA 2634
Score = 45.8 bits (107), Expect = 1e-04
Identities = 123/564 (21%), Positives = 211/564 (37%), Gaps = 76/564 (13%)
Query: 159 SLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQEL 218
+L KQ +A AER A + ++E+VR + + + +K ++Q+E+Q+L
Sbjct: 1395 ALEKQRQLAEAHAQAKAQAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
Query: 219 QDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQIL 278
+ S ++A + A+R ++ + RL+ ++ +
Sbjct: 1453 RQS------------SEAEIQAKARQAEAAERSRLRIEEEIRVV-----RLQLEATERQR 1495
Query: 279 GSLPN--QPLSPEMHIMEAQMEQLRGSIEKLK------CFNRLLSAVLQGYKGRCEGLSM 330
G Q L EAQ Q + E+L+ + + V + + E +
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555
Query: 331 QLGQREAEATALHLALQYSE--------HCEEAYRVLLALREADSGAGDEAPMSDLQAAE 382
+ QR +A L LQ E E A +V +AL A A E AE
Sbjct: 1556 REKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1614
Query: 383 KEAW--RLLAQEEAA---MDAGAQQNPQPSPEGSSVDKPTPQEV---------AFQLRSY 428
K A R L +E A + A++ Q E + +E+ A +LR
Sbjct: 1615 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1674
Query: 429 VQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQ-----IQ 483
+ + +++SL + +E A R +A QA+ Q A LEK +
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEKQRQLAEGTA 1732
Query: 484 QDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRWE----RAELQ 539
Q +AA + L L + ++++ LE A L+ A ++L E RAE++
Sbjct: 1733 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1792
Query: 540 AGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLT 599
A+ + +S E+ Q L A + G+ + + LA
Sbjct: 1793 VLLASKARAEEESRSTS---EKSKQRLEA--------EAGRFRELAEEAARLRALAEEAK 1841
Query: 600 RTLDL-QEQLQSLRRELEQVAQKGRARRSQSAELNRD---LCKAHSALVLAFRGAHRKQE 655
R L +E R E E+V + A ++ L + K A R +
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 656 EQRRKLEQQMALMEAQQAEEVAVL 679
QRR+LE+Q A +A E +A L
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQL 1925
Score = 39.3 bits (90), Expect = 0.013
Identities = 111/528 (21%), Positives = 196/528 (37%), Gaps = 49/528 (9%)
Query: 168 SCQREAARLAERNAWLRLALSSREDEL-VRTQASLEAIR-----AEKETLQKEVQELQDS 221
S ++ AA AE L S+ ED L + QA LEA R AE+E ++E +E
Sbjct: 1960 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2019
Query: 222 LLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSL 281
L E + ++ E +R + ++ A L R S+ Q+ L
Sbjct: 2020 SLAAE--------EEAARQRKAALEEVERLKAKVEE----ARRLRERAEQESARQL--QL 2065
Query: 282 PNQPLSPEMHIME-AQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQ-REAEA 339
+ + E A ++ ++L+ + +VL +G E + EA
Sbjct: 2066 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2125
Query: 340 TALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAG 399
A A Q EEA R+ A ++A A E R A++EAA A
Sbjct: 2126 QAEREAAQSRRQVEEAERL-------KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2178
Query: 400 AQQNPQPSPEGSSVDKPTPQEVAFQ-LRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRA 458
A+Q + + + ++ A Q LR Q QE +L L E T +
Sbjct: 2179 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---------TDHQK 2229
Query: 459 EAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREA-AL 517
+ + + +A +++Q++++L + R + +L + E R L LR+
Sbjct: 2230 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2289
Query: 518 RALGPAHVLLLEQLRWERAEL-----QAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGG 572
+ ++Q+ E A L +A + E+ + + AV
Sbjct: 2290 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2349
Query: 573 TSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAEL 632
T + ++LAQE A L D ++ Q L E + + A R + E+
Sbjct: 2350 TR--LKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405
Query: 633 NRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
+ + + + R R +E+ +R +Q + E E+A E
Sbjct: 2406 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2453
Score = 31.2 bits (69), Expect = 3.4
Identities = 52/200 (26%), Positives = 88/200 (44%), Gaps = 18/200 (9%)
Query: 200 SLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSF 259
SLE E+ Q+ + EL+D L+LE C + ++ + E + E Q +
Sbjct: 998 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1057
Query: 260 SLAHPL---LRRLRSHSSTQILGSLPNQPLSP----EMHIMEAQMEQLRG----SIEKLK 308
+ L + RL S + ++L P +P E+ + ++EQ+R +EKLK
Sbjct: 1058 AEVEGLGKGVARL-SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1116
Query: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSG 368
+S V++G +G E L Q + EA A+ L E + + + L A EA
Sbjct: 1117 ----TISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQP 1171
Query: 369 AGDEAPMSDLQAAEKEAWRL 388
D A +L+ A++ RL
Sbjct: 1172 TFD-ALRDELRGAQEVGERL 1190
>gi|221219026 pleckstrin homology-like domain, family B, member 1
isoform b [Homo sapiens]
Length = 1319
Score = 48.1 bits (113), Expect = 3e-05
Identities = 117/526 (22%), Positives = 185/526 (35%), Gaps = 110/526 (20%)
Query: 157 AGSLGKQEGAGSCQREAARLAERNAWLRL-----------ALSSREDELVRTQASLEAIR 205
A SLG GA CQ + + LR+ +S ED+L+ R
Sbjct: 541 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER 600
Query: 206 AEKETLQKEVQELQDSLLRLEPCPHLSHNQAG---------------------------G 238
++ +++ ++ +++L L C S G
Sbjct: 601 LREQEMERLERQRLETILNL--CAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLA 658
Query: 239 SGSGSSSSE---ADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEA 295
SG SS E A + WE+ + + + S+ Q P+ L E+ +E
Sbjct: 659 GASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEE 718
Query: 296 QMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEA 355
+ Q+ G +E+LK R + L QL + EA LQ E A
Sbjct: 719 ERAQVLGHVEQLKV--------------RVKELEQQLQESAREAEMERALLQGEREAERA 764
Query: 356 YRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDK 415
L E++A L ++ A++ G Q+ E +
Sbjct: 765 ----------------------LLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETET 802
Query: 416 PTPQEVAFQLRSYVQRLQERRSL--MKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPA 473
+++ FQ R++E R L +L L + R E + AIL +QAG
Sbjct: 803 KLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSI--AKRKERL--AILDSQAG-- 856
Query: 474 LPRLEKTQIQQDLVAAREALA-DLMLRLQLVRREKRGLELREAALRALG-----PAHVLL 527
QI+ V E LA D LQL+++EK L + E +L P
Sbjct: 857 -------QIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTST 909
Query: 528 LEQLRWERAELQAGG----ANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGR 583
L+++ + + +A S SS G SS + L P S + Q G
Sbjct: 910 LKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSAL-LTQNGT 968
Query: 584 AWDPEKLAQELAASLT-RTLDLQEQ----LQSLRRELEQVAQKGRA 624
P LA L T R L LQ++ ++ RR L ++ QK A
Sbjct: 969 GSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAA 1014
Score = 40.0 bits (92), Expect = 0.007
Identities = 121/521 (23%), Positives = 182/521 (34%), Gaps = 116/521 (22%)
Query: 184 RLALSSREDELVRT--QASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGS 241
+L S+RE E+ R Q EA RA + QK V +LQ+ L+ LE
Sbjct: 740 QLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALET-------------- 785
Query: 242 GSSSSEADREPWETQDSFSLAHPL-LRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQL 300
E D+E + L L ++L S + L Q L + ++ E L
Sbjct: 786 -GIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGL------LRSKAELL 838
Query: 301 RGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLL 360
R SI K K RL A+L G+ ++Q +R A L L E +E VL
Sbjct: 839 R-SIAKRK--ERL--AILDSQAGQIRAQAVQESERLARDKNASLQLLQKE--KEKLTVLE 891
Query: 361 ALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAG-AQQNPQPSPEGSSVDK---- 415
+ +G P + KE +R EA + P PS GSS
Sbjct: 892 RRYHSLTGG---RPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLS 948
Query: 416 -------PTPQEVAF----------QLRSYVQRLQERRSL------MKILSEPGPTLAPM 452
P+P+ L + +Q ++ +R L +++ E LA +
Sbjct: 949 VATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAEL 1008
Query: 453 PTVPRAEAMVQ--AILGTQAGPA----LPRLEKTQIQQDLVAAREALADLMLRLQLVRRE 506
AEA Q A+ G PA P L I L A RE
Sbjct: 1009 KQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRE--------------- 1053
Query: 507 KRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGL 566
RG E A ++ L++ + + S+GG S+
Sbjct: 1054 -RGEEGEHA-----------------YDTLSLESSDSMETS-ISTGGNSA---------- 1084
Query: 567 PAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARR 626
P S G +G+ + EK+ +E A R ++ +E+ LRR Q ++ R RR
Sbjct: 1085 -CSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRR---QALEEERRRR 1140
Query: 627 SQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMAL 667
Q + LV KQ Q R L + + +
Sbjct: 1141 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPI 1181
>gi|32484977 angiomotin like 2 [Homo sapiens]
Length = 780
Score = 48.1 bits (113), Expect = 3e-05
Identities = 99/423 (23%), Positives = 161/423 (38%), Gaps = 105/423 (24%)
Query: 140 PPSHSGPMEFEGTSE-GGAGSLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQ 198
PP+ GP+ + +S G+ L + E RE ARL N L+ L S ++ R +
Sbjct: 290 PPAVEGPVSAQASSATSGSAHLAQMEAV---LRENARLQRDNERLQRELESSAEKAGRIE 346
Query: 199 A-------------SLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGSGSSS 245
SL +++E L+K ++ DS +R + + S + +
Sbjct: 347 KLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLA 406
Query: 246 SEADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIE 305
S+ TQ++ + + ++ +L + S Q E +E +M LRG+IE
Sbjct: 407 SK-------TQEAQAGSQDMVAKLLAQSYEQ----------QQEQEKLEREMALLRGAIE 449
Query: 306 KLKCFNRLLSAVLQGYKGRCEGLSMQLGQREA---EATALHLAL-QYSEHCEEAYRVLLA 361
+ LL L +GR +L +++A + L AL Q CE+ ++ L
Sbjct: 450 DQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELR 509
Query: 362 LRE--------------------ADSGAGDEAPMSDL----QAAEKEAWRLL-------- 389
LR SG+G +S L Q EKE L
Sbjct: 510 LRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKW 569
Query: 390 --------AQEEAAMDAGA-----------QQNPQPSP-----EGSSVDKPTPQEVAFQL 425
A + AMDA A + +PQPSP EG QE+ +L
Sbjct: 570 EQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRL 629
Query: 426 RSYVQRLQERRSLMKILS-----EPGP----TLAPMPTVPRAEAMVQAILGTQAGPALPR 476
+ ++ E+ +++K+L +PG +L P +VP A A GTQ L
Sbjct: 630 KVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSLRPAKSVPSVFAAAAA--GTQGWQGLSS 687
Query: 477 LEK 479
E+
Sbjct: 688 SER 690
Score = 36.6 bits (83), Expect = 0.082
Identities = 32/120 (26%), Positives = 50/120 (41%), Gaps = 5/120 (4%)
Query: 567 PAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARR 626
PAV G S Q A ++ A L LQ + L+RELE A+K
Sbjct: 291 PAVEGPVSA----QASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIE 346
Query: 627 SQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLEATARAL 686
+E+ R L +AH +L A ++ R K++ +M ++ + LE+ R L
Sbjct: 347 KLESEIQR-LSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRL 405
Score = 33.1 bits (74), Expect = 0.90
Identities = 35/178 (19%), Positives = 68/178 (38%), Gaps = 18/178 (10%)
Query: 514 EAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGT 573
+A+ G AH+ +E + E A LQ S +G E+ + +
Sbjct: 300 QASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAH 359
Query: 574 SGIDGGQVGRAWDPEKLAQELAASLTR----TLDLQEQLQSLRRELEQVAQKGRARRSQS 629
+ R + + ++ + + R DL+E+L+S R L Q+ +A
Sbjct: 360 ESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQD- 418
Query: 630 AELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLEATARALG 687
+V +Q++++ KLE++MAL+ ++ E +ALG
Sbjct: 419 -------------MVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALG 463
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 47.8 bits (112), Expect = 4e-05
Identities = 113/589 (19%), Positives = 213/589 (36%), Gaps = 74/589 (12%)
Query: 133 AAAWRHQPPSHSGPMEFEGTSEGGAGSLGKQEGAGSCQREAARLAERNAWLRLALSSRED 192
AAA HQ E + S+ + A Q E ++ +
Sbjct: 367 AAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLK-------------- 412
Query: 193 ELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEP-------CPHLSHNQAGGSGSGSSS 245
E +R + LEA+ E KE ELQ L L C H S + S S
Sbjct: 413 EKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQR-----QDSLS 467
Query: 246 SEAD---REPWETQDSFSLAHPLLRR----LRSHSSTQILGSLPNQPLSPEMHIMEAQME 298
SE D + W+ + + + +L L S ++ + Q L ++ M+ M
Sbjct: 468 SEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSML 527
Query: 299 QLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEH----CEE 354
++ L+ L + LQ + L+ +L +AE ++L Q+ + +E
Sbjct: 528 SKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQE 587
Query: 355 AYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVD 414
A RV L A G L+ + E L Q ++ + + + ++
Sbjct: 588 A-RVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIE 646
Query: 415 KPT-PQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPA 473
QE AF + + E ++ G R + M + +
Sbjct: 647 ADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGER-------ERLQRMADSAASLEQQLE 699
Query: 474 LPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLEQLRW 533
+L Q Q L A ++ DLM +L L + L+ RE +L AL + ++L+
Sbjct: 700 QVKLTLLQRDQQLEALQQEHLDLMKQLTLTQE---ALQSREQSLDALQTHY----DELQA 752
Query: 534 ERAELQAGGANSSGG------------HSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQV 581
ELQ A+ + SG EE + G ++ G
Sbjct: 753 RLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEE--------LDRGARRLEEGTE 804
Query: 582 GRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHS 641
+ EKL +ELA + LQ++ +L+++++++ ++ ++ RD +
Sbjct: 805 ETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRD-ATSKD 863
Query: 642 ALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLEATARALGKPR 690
L+ + ++ + + ++L Q++ + ++ A L R + + R
Sbjct: 864 QLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVR 912
Score = 34.3 bits (77), Expect = 0.41
Identities = 74/387 (19%), Positives = 147/387 (37%), Gaps = 40/387 (10%)
Query: 160 LGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQ 219
L + + + Q+E L ++ + AL SRE L Q + ++A LQ E +
Sbjct: 706 LQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASRE 765
Query: 220 DSLLRLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQILG 279
D++ L+ + +A + S E DR ++ L +LR + +
Sbjct: 766 DTICLLQNEKIIL--EAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIK--- 820
Query: 280 SLPNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEA 339
S ++ ++ + L+ ++K+K +++ Y R + S E +A
Sbjct: 821 -------SGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAY--RRDATSKDQLISELKA 871
Query: 340 TALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAG 399
T L + E +E +V R A EA +S L + + +A E + +
Sbjct: 872 TRKRLDSELKELRQELMQVHGEKRTA------EAELSRLHREVAQVRQHMADLEGHLQSA 925
Query: 400 AQQNPQPSPEGSSVDKPTPQEVAF-----QLRSYVQRLQ---------ERRSLMKILSEP 445
++ + S+ Q VA L+ ++ LQ +++ + ++ S+
Sbjct: 926 QKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDL 985
Query: 446 GPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRR 505
M T +A IL + AL E + + A+ +D L L
Sbjct: 986 TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALH---- 1041
Query: 506 EKRGLELREAALRALGPAHVLLLEQLR 532
++ EA L+A+ + LL ++L+
Sbjct: 1042 --ERIQALEAELQAVSHSKTLLEKELQ 1066
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 47.0 bits (110), Expect = 6e-05
Identities = 72/341 (21%), Positives = 136/341 (39%), Gaps = 21/341 (6%)
Query: 360 LALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDK---- 415
+A +A + AG+ L A E+E + A+ +A+ ++ Q + ++ +
Sbjct: 297 MAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLEN 356
Query: 416 -PTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPM---------PTVPRAEAMVQAI 465
P Q Q + + R ++ ++ S+ LA + V ++EA+ Q
Sbjct: 357 GPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDE 416
Query: 466 LGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHV 525
+A A + Q+ Q + RE+ L RL V RE + A+LRA
Sbjct: 417 QQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQ 476
Query: 526 LLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWY----QGLPAVPGGTSGIDGGQV 581
+Q+ ++LQ+ A G G +E Q + + ++ GQ
Sbjct: 477 EQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQA 536
Query: 582 GRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHS 641
A D + E TR +L+ Q+ L +E ++ + ++ ++ +L KA
Sbjct: 537 RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAME 596
Query: 642 ALVLAFRGAHRKQE---EQRRKLEQQMALMEAQQAEEVAVL 679
AL A + K + + + E+Q+ L+EAQ E + L
Sbjct: 597 ALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLAL 637
Score = 30.4 bits (67), Expect = 5.9
Identities = 62/300 (20%), Positives = 109/300 (36%), Gaps = 34/300 (11%)
Query: 172 EAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPC--- 228
E A+L + + + L + + + + + +A+ A+ +K+V +LQ S E
Sbjct: 390 ELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQK 449
Query: 229 ------PHLSHNQAGGSGSGSSSSEADRE-PWETQDSFSLAHPLLRRLRSHSSTQILGSL 281
L H Q S +S AD E E Q + H L+ + ++
Sbjct: 450 RLDEVSRELCHTQ-----SSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSK----- 499
Query: 282 PNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATA 341
E+ + Q+++ R +L R + A+L+ + R + +Q Q EA+
Sbjct: 500 -----CEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQAR-DAQDVQASQAEADQQQ 553
Query: 342 LHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQ 401
L + + + LREA + +DL+ +A LA E A
Sbjct: 554 TRLK-ELESQVSGLEKEAIELREAVE--QQKVKNNDLREKNWKAMEALATAEQACKEKLH 610
Query: 402 QNPQPSPEGSS----VDKPTPQEVAFQLRSY-VQRLQERRSLMKILSEPGPTLAPMPTVP 456
Q E ++ T + + L V Q ++ L E GPTL P P
Sbjct: 611 SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAP 670
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 47.0 bits (110), Expect = 6e-05
Identities = 72/341 (21%), Positives = 136/341 (39%), Gaps = 21/341 (6%)
Query: 360 LALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDK---- 415
+A +A + AG+ L A E+E + A+ +A+ ++ Q + ++ +
Sbjct: 297 MAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLEN 356
Query: 416 -PTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPM---------PTVPRAEAMVQAI 465
P Q Q + + R ++ ++ S+ LA + V ++EA+ Q
Sbjct: 357 GPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDE 416
Query: 466 LGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHV 525
+A A + Q+ Q + RE+ L RL V RE + A+LRA
Sbjct: 417 QQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQ 476
Query: 526 LLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWY----QGLPAVPGGTSGIDGGQV 581
+Q+ ++LQ+ A G G +E Q + + ++ GQ
Sbjct: 477 EQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQA 536
Query: 582 GRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHS 641
A D + E TR +L+ Q+ L +E ++ + ++ ++ +L KA
Sbjct: 537 RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAME 596
Query: 642 ALVLAFRGAHRKQE---EQRRKLEQQMALMEAQQAEEVAVL 679
AL A + K + + + E+Q+ L+EAQ E + L
Sbjct: 597 ALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLAL 637
Score = 30.4 bits (67), Expect = 5.9
Identities = 62/300 (20%), Positives = 109/300 (36%), Gaps = 34/300 (11%)
Query: 172 EAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPC--- 228
E A+L + + + L + + + + + +A+ A+ +K+V +LQ S E
Sbjct: 390 ELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQK 449
Query: 229 ------PHLSHNQAGGSGSGSSSSEADRE-PWETQDSFSLAHPLLRRLRSHSSTQILGSL 281
L H Q S +S AD E E Q + H L+ + ++
Sbjct: 450 RLDEVSRELCHTQ-----SSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSK----- 499
Query: 282 PNQPLSPEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATA 341
E+ + Q+++ R +L R + A+L+ + R + +Q Q EA+
Sbjct: 500 -----CEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQAR-DAQDVQASQAEADQQQ 553
Query: 342 LHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQ 401
L + + + LREA + +DL+ +A LA E A
Sbjct: 554 TRLK-ELESQVSGLEKEAIELREAVE--QQKVKNNDLREKNWKAMEALATAEQACKEKLH 610
Query: 402 QNPQPSPEGSS----VDKPTPQEVAFQLRSY-VQRLQERRSLMKILSEPGPTLAPMPTVP 456
Q E ++ T + + L V Q ++ L E GPTL P P
Sbjct: 611 SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAP 670
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 44.3 bits (103), Expect = 4e-04
Identities = 88/408 (21%), Positives = 142/408 (34%), Gaps = 95/408 (23%)
Query: 157 AGSLGKQEGAGSCQREAARLAERNAWLRL-----------ALSSREDELVRTQASLEAIR 205
A SLG GA CQ + + LR+ +S ED+L+ R
Sbjct: 541 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER 600
Query: 206 AEKETLQKEVQELQDSLLRLEPCPHLSHNQAG---------------------------G 238
++ +++ ++ +++L L C S G
Sbjct: 601 LREQEMERLERQRLETILNL--CAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLA 658
Query: 239 SGSGSSSSE---ADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEA 295
SG SS E A + WE+ + + + S+ Q P+ L E+ +E
Sbjct: 659 GASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEE 718
Query: 296 QMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEA 355
+ Q+ G +E+LK R + L QL + EA LQ E A
Sbjct: 719 ERAQVLGHVEQLKV--------------RVKELEQQLQESAREAEMERALLQGEREAERA 764
Query: 356 YRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDK 415
L E++A L ++ A++ G Q+ E +
Sbjct: 765 ----------------------LLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETET 802
Query: 416 PTPQEVAFQLRSYVQRLQERRSL--MKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPA 473
+++ FQ R++E R L +L L + R E + AIL +QAG
Sbjct: 803 KLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSI--AKRKERL--AILDSQAG-- 856
Query: 474 LPRLEKTQIQQDLVAAREALA-DLMLRLQLVRREKRGLELREAALRAL 520
QI+ V E LA D LQL+++EK L + E +L
Sbjct: 857 -------QIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSL 897
Score = 43.5 bits (101), Expect = 7e-04
Identities = 122/529 (23%), Positives = 186/529 (35%), Gaps = 85/529 (16%)
Query: 184 RLALSSREDELVRT--QASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGS 241
+L S+RE E+ R Q EA RA + QK V +LQ+ L+ LE
Sbjct: 740 QLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALET-------------- 785
Query: 242 GSSSSEADREPWETQDSFSLAHPL-LRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQL 300
E D+E + L L ++L S + L Q L + ++ E L
Sbjct: 786 -GIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGL------LRSKAELL 838
Query: 301 RGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEH-----CEEA 355
R SI K K RL A+L G+ ++Q +R A L L E E
Sbjct: 839 R-SIAKRK--ERL--AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERR 893
Query: 356 YRVLLALREADSGAGDEAPMSDL--QAAEKEAWRLLAQEEAAMDAG-AQQNPQPSPEGSS 412
Y L R M L A + E W + A + G A +P SP
Sbjct: 894 YHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQW--YQELMAGLGTGPAAASPHSSPP--- 948
Query: 413 VDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGP 472
P P + + QL+ Y ++ + + GP + + + + A LG P
Sbjct: 949 ---PLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP 1005
Query: 473 ALPRLEKT---QIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLE 529
L + + ++L A L D+ + QL ++K + E R E
Sbjct: 1006 KSALLTQNGTGSLPRNLAAT---LQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAE 1062
Query: 530 -QLRWER----AELQAGGA-------NSSGGHSSGGGSSGDE-EEWYQGLP--------- 567
Q +W+ A AG + +S H G G+E E Y L
Sbjct: 1063 AQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMET 1122
Query: 568 ---------AVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQV 618
P S G +G+ + EK+ +E A R ++ +E+ LRR Q
Sbjct: 1123 SISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRR---QA 1179
Query: 619 AQKGRARRSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMAL 667
++ R RR Q + LV KQ Q R L + + +
Sbjct: 1180 LEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPI 1228
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 44.3 bits (103), Expect = 4e-04
Identities = 88/408 (21%), Positives = 142/408 (34%), Gaps = 95/408 (23%)
Query: 157 AGSLGKQEGAGSCQREAARLAERNAWLRL-----------ALSSREDELVRTQASLEAIR 205
A SLG GA CQ + + LR+ +S ED+L+ R
Sbjct: 541 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER 600
Query: 206 AEKETLQKEVQELQDSLLRLEPCPHLSHNQAG---------------------------G 238
++ +++ ++ +++L L C S G
Sbjct: 601 LREQEMERLERQRLETILNL--CAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLA 658
Query: 239 SGSGSSSSE---ADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEA 295
SG SS E A + WE+ + + + S+ Q P+ L E+ +E
Sbjct: 659 GASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEE 718
Query: 296 QMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEA 355
+ Q+ G +E+LK R + L QL + EA LQ E A
Sbjct: 719 ERAQVLGHVEQLKV--------------RVKELEQQLQESAREAEMERALLQGEREAERA 764
Query: 356 YRVLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDK 415
L E++A L ++ A++ G Q+ E +
Sbjct: 765 ----------------------LLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETET 802
Query: 416 PTPQEVAFQLRSYVQRLQERRSL--MKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPA 473
+++ FQ R++E R L +L L + R E + AIL +QAG
Sbjct: 803 KLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSI--AKRKERL--AILDSQAG-- 856
Query: 474 LPRLEKTQIQQDLVAAREALA-DLMLRLQLVRREKRGLELREAALRAL 520
QI+ V E LA D LQL+++EK L + E +L
Sbjct: 857 -------QIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSL 897
Score = 43.5 bits (101), Expect = 7e-04
Identities = 122/529 (23%), Positives = 186/529 (35%), Gaps = 85/529 (16%)
Query: 184 RLALSSREDELVRT--QASLEAIRAEKETLQKEVQELQDSLLRLEPCPHLSHNQAGGSGS 241
+L S+RE E+ R Q EA RA + QK V +LQ+ L+ LE
Sbjct: 740 QLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALET-------------- 785
Query: 242 GSSSSEADREPWETQDSFSLAHPL-LRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQL 300
E D+E + L L ++L S + L Q L + ++ E L
Sbjct: 786 -GIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGL------LRSKAELL 838
Query: 301 RGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEH-----CEEA 355
R SI K K RL A+L G+ ++Q +R A L L E E
Sbjct: 839 R-SIAKRK--ERL--AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERR 893
Query: 356 YRVLLALREADSGAGDEAPMSDL--QAAEKEAWRLLAQEEAAMDAG-AQQNPQPSPEGSS 412
Y L R M L A + E W + A + G A +P SP
Sbjct: 894 YHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQW--YQELMAGLGTGPAAASPHSSPP--- 948
Query: 413 VDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGP 472
P P + + QL+ Y ++ + + GP + + + + A LG P
Sbjct: 949 ---PLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP 1005
Query: 473 ALPRLEKT---QIQQDLVAAREALADLMLRLQLVRREKRGLELREAALRALGPAHVLLLE 529
L + + ++L A L D+ + QL ++K + E R E
Sbjct: 1006 KSALLTQNGTGSLPRNLAAT---LQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAE 1062
Query: 530 -QLRWER----AELQAGGA-------NSSGGHSSGGGSSGDE-EEWYQGLP--------- 567
Q +W+ A AG + +S H G G+E E Y L
Sbjct: 1063 AQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMET 1122
Query: 568 ---------AVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQV 618
P S G +G+ + EK+ +E A R ++ +E+ LRR Q
Sbjct: 1123 SISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRR---QA 1179
Query: 619 AQKGRARRSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMAL 667
++ R RR Q + LV KQ Q R L + + +
Sbjct: 1180 LEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPI 1228
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 44.3 bits (103), Expect = 4e-04
Identities = 134/583 (22%), Positives = 216/583 (37%), Gaps = 103/583 (17%)
Query: 157 AGSLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQ 216
AG+L Q+ SC +E + +S E E ++ Q E +R K ++E +
Sbjct: 365 AGNLHPQQDQ-SCLKECPCMKGGTDMQTKKEASAETEYMKQQYE-EDLRKIKHQTEEEKK 422
Query: 217 ELQDSLL-RLEPCPHLSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLRRLRSHSST 275
L+D L+ RLE L S SS EA+R+ + + L +R S
Sbjct: 423 HLKDQLVKRLED---LVKKHTVEIKSVRSSVEAERKKLQRE-----VEAQLEEVRKKSEK 474
Query: 276 QILGSLPNQPLSPEMHIMEAQMEQLR-------------GSIEKLKCFNRLLSAVLQGYK 322
+I L + + + + + +E LR G+ E + R ++L+ +
Sbjct: 475 EIK-QLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILET-Q 532
Query: 323 GRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREADSGAGDEAPMSDLQAAE 382
C L + E LA + +E R + L+E G+ + P+ L +
Sbjct: 533 DPC--LKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKE---GSDPQPPLGSL--LK 585
Query: 383 KEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRSYVQRLQ-----ERRS 437
++ ++ EE A+ Q S ++++ T R +Q L+ ER
Sbjct: 586 EKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSN-----YREDLQALKQLSDLEREK 640
Query: 438 LMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALA--- 494
L + L E T + AM +A L AL LEK + Q+L A E L
Sbjct: 641 LQRELQE---------TTQQNHAM-KAQLEASHQRALRMLEKAR-HQELKATEERLKKES 689
Query: 495 --DLMLRLQLVRREKRGLE------LREAALRALGPAHVLLLEQLRWE------------ 534
L ++ Q R E + LE L+E R + LLLE LR E
Sbjct: 690 SHSLQIQHQTHRLELQALEEKARQELQEERER-MQAQQALLLESLRQELSEQQAACSGHQ 748
Query: 535 ------RAELQAGGANSSGGHSSGGGSS---GDEEEWYQGLPAVPGGTSGIDGGQVGRAW 585
+AEL+A G + G EE G P G +G G+ W
Sbjct: 749 KDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLW 808
Query: 586 DPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHSALVL 645
+ LQ+ ++ LR E+EQ Q+ + R Q L + V
Sbjct: 809 E-------------ENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVE 855
Query: 646 AFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLEATARALGK 688
R HRK + + + + +AQ +A LEA + G+
Sbjct: 856 TLRQEHRK---EMQAMVADFSSAQAQLQARLAALEAELKDSGE 895
>gi|18644728 nucleolar protein family 6 alpha isoform [Homo sapiens]
Length = 1146
Score = 43.1 bits (100), Expect = 9e-04
Identities = 68/281 (24%), Positives = 109/281 (38%), Gaps = 46/281 (16%)
Query: 247 EADREPWETQDSFSLAHPLLRRLRSHSSTQILGSLPNQPLSPEMHIMEAQMEQLRGSIEK 306
+ ++P + +DS +L LL R +S LG +QP + A+ Q GS +
Sbjct: 536 DISQDPPKHKDSGTLTLGLLLRPEGLTSVLELGPEADQPEA-------AKFRQFWGSRSE 588
Query: 307 LKCFN--RLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYR------- 357
L+ F + AV+ E SM + HL +++ E
Sbjct: 589 LRRFQDGAIREAVVW------EAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLD 642
Query: 358 -VLLALREADSGAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKP 416
++ L+E S G+EA ++ ++ + + L E + A Q P + V P
Sbjct: 643 ALIQGLKETSS-TGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPP 701
Query: 417 TPQEVAFQLRSYVQRLQERRSLMKILSEPGPT-LAPMPTVPRAEAMVQAILGTQAGPALP 475
TP AF S+ + L+ER SL+ L +P P + PM V E
Sbjct: 702 TPVRPAF---SFYETLRERSSLLPRLDKPCPAYVEPMTVVCHLEG--------------- 743
Query: 476 RLEKTQIQQDLVAAREALADLMLRLQLVRREKRGLELREAA 516
Q QD A + A LRL + ++ GL+ R A
Sbjct: 744 ---SGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATA 781
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 41.6 bits (96), Expect = 0.003
Identities = 114/533 (21%), Positives = 212/533 (39%), Gaps = 91/533 (17%)
Query: 170 QREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCP 229
QRE +E + +++L T+ L +R EKE +++E+ E + L R
Sbjct: 558 QRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQR----- 612
Query: 230 HLSHNQAGGSGSGSSSSEA-DREPWETQDSFSLAHPLLRRLRS-HSSTQILGSLPNQPLS 287
QA S + E +E TQ+ L+ L++ S ++ G ++ L
Sbjct: 613 --ELEQARASAGDTRQVEVLKKELLRTQEE-------LKELQAERQSQEVAGRHRDRELE 663
Query: 288 PEMHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATAL----- 342
++ ++ + ++ R +L+ N L LQ + CE S EAEAT L
Sbjct: 664 KQLAVLRVEADRGR----ELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRA 719
Query: 343 ---HLALQYSEHCEEAYRVLLALRE--------ADSGAGDEAPMSD-LQAAEKEAWRLLA 390
+ E +E R +L L + D G EA + D LQ E E +L
Sbjct: 720 AVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQL-- 777
Query: 391 QEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQ--LRSYVQRLQERRSLMKILSEPGPT 448
E A++A ++ EGS E + R + QE+++L + L E G
Sbjct: 778 --EEALNASQEE------EGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQ 829
Query: 449 LAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRREKR 508
+ +AE Q L + L + E +I +D +++AL L +L+ + + R
Sbjct: 830 REVLRR-GKAELEEQKRLLDRTVDRLNK-ELEKIGED---SKQALQQLQAQLEDYKEKAR 884
Query: 509 GLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPA 568
RE A A+ QA S +SGG S +E
Sbjct: 885 ----REVA------------------DAQRQAKDWASEAEKTSGGLSRLQDE-------- 914
Query: 569 VPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQ 628
+ + Q R D +L +EL A R L+++ ++ +R + A++ + +
Sbjct: 915 IQRLRQALQASQAER--DTARLDKELLAQ--RLQGLEQEAENKKRSQDDRARQLKGLEEK 970
Query: 629 SAELNRDLCKAHSALVLAFRGAHR---KQEEQRRKLEQQMALMEAQQAEEVAV 678
+ L +L + + + L +R + ++ R +L Q+ + + + +++++
Sbjct: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISL 1023
Score = 40.4 bits (93), Expect = 0.006
Identities = 121/574 (21%), Positives = 219/574 (38%), Gaps = 99/574 (17%)
Query: 171 REAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLEPCPH 230
++ +L L L + +E R Q LE + E + KE+Q ++ L + E H
Sbjct: 380 KKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRH 439
Query: 231 --------LSHNQAGGSGSGSSSSEADREPWETQDSFSLAHPLLR---------RLRSHS 273
L + G + ++ ET++ L +L RLR
Sbjct: 440 GLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRE---LLEEVLEGKQRVEEQLRLRERE 496
Query: 274 STQILGSLPNQPLSPEMHIMEAQM------EQLRGSIEK-------LKCFNRLLSAVLQG 320
T + G+L + S + + + EQLR S++ L+ + +SA+++G
Sbjct: 497 LTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRG 556
Query: 321 YKGRCEGLSMQLGQ------------REAEATALHLALQYSEHCEE-AYRVLLALREADS 367
+ E S + G R + L L ++ E EE ++ + RE +
Sbjct: 557 LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQ 616
Query: 368 GAGDEAPMSDLQAAEKEAWRLLAQEEAAMDAGAQQNPQPSPEGSSVDKPTPQEVAFQLRS 427
++ +KE LL +E + A++ Q G D+ +++A LR
Sbjct: 617 ARASAGDTRQVEVLKKE---LLRTQEELKELQAERQSQ-EVAGRHRDRELEKQLAV-LRV 671
Query: 428 YVQR--------LQERRSLMKILSEPGPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEK 479
R LQ +++L + L + + V AEA V LG + L +
Sbjct: 672 EADRGRELEEQNLQLQKTLQQ-LRQDCEEASKAKMVAEAEATV---LGQRRAAVETTLRE 727
Query: 480 TQIQQDLVAAREALADLMLRLQLVRREKRGL----ELREAALRALGPAHVLLLEQLRWER 535
TQ + D R +L L+ +E RGL E EA LR L++L E+
Sbjct: 728 TQEENDEFRRR------ILGLEQQLKETRGLVDGGEAVEARLRDK-------LQRLEAEK 774
Query: 536 AELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPGGTSGIDGGQVGRAWDPEKLAQELA 595
+L+ + +EE A + ++ Q G A +L QE
Sbjct: 775 QQLEEA-------------LNASQEEEGSLAAAKRALEARLEEAQRGLA----RLGQE-Q 816
Query: 596 ASLTRTLDLQ-EQLQSLRRELEQVAQKGRARRSQSAELNRDLCKAHSALVLAFRGAHRKQ 654
+L R L+ + +Q + LRR ++ ++ R LN++L K A + +
Sbjct: 817 QTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQL 876
Query: 655 EEQRRKLEQQMALMEAQQAEEVAVLEATARALGK 688
E+ + K +++A + Q + + E T+ L +
Sbjct: 877 EDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,159,325
Number of Sequences: 37866
Number of extensions: 1592344
Number of successful extensions: 12224
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 101
Number of HSP's successfully gapped in prelim test: 445
Number of HSP's that attempted gapping in prelim test: 10316
Number of HSP's gapped (non-prelim): 2139
length of query: 703
length of database: 18,247,518
effective HSP length: 109
effective length of query: 594
effective length of database: 14,120,124
effective search space: 8387353656
effective search space used: 8387353656
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.