Search of human proteins with 31377798

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31377798 rabaptin, RAB GTPase binding effector protein 1
isoform 1 [Homo sapiens]
         (862 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isof...  1649   0.0  
gi|134152674 rabaptin, RAB GTPase binding effector protein 1 iso...  1574   0.0  
gi|117956403 rabaptin, RAB GTPase binding effector protein 2 [Ho...   189   7e-48
gi|21735548 centrosomal protein 2 [Homo sapiens]                      121   2e-27
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   118   2e-26
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   112   2e-24
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    111   3e-24
gi|71061468 centromere protein E [Homo sapiens]                       111   3e-24
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       110   6e-24
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       110   6e-24
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        110   6e-24
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        110   6e-24
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        110   6e-24
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        110   6e-24
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        110   6e-24
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        110   6e-24
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   109   1e-23
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   109   1e-23
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   109   1e-23
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   109   1e-23
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]              103   5e-22
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            103   5e-22
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   103   7e-22
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   103   7e-22
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   102   2e-21
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   100   6e-21
gi|148746195 trichohyalin [Homo sapiens]                              100   6e-21
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   100   6e-21
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               100   8e-21
gi|58530840 desmoplakin isoform I [Homo sapiens]                      100   1e-20

>gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isoform
           1 [Homo sapiens]
          Length = 862

 Score = 1649 bits (4270), Expect = 0.0
 Identities = 862/862 (100%), Positives = 862/862 (100%)

Query: 1   MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ 60
           MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
Sbjct: 1   MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ 60

Query: 61  NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV 120
           NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
Sbjct: 61  NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV 120

Query: 121 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED 180
           MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
Sbjct: 121 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED 180

Query: 181 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV 240
           AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
Sbjct: 181 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV 240

Query: 241 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR 300
           LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
Sbjct: 241 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR 300

Query: 301 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ 360
           MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
Sbjct: 301 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ 360

Query: 361 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420
           LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK
Sbjct: 361 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420

Query: 421 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
           ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT
Sbjct: 421 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480

Query: 481 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
           PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE
Sbjct: 481 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540

Query: 541 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV 600
           KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV
Sbjct: 541 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV 600

Query: 601 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV 660
           LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV
Sbjct: 601 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV 660

Query: 661 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK 720
           SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK
Sbjct: 661 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK 720

Query: 721 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE 780
           ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE
Sbjct: 721 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE 780

Query: 781 EQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS 840
           EQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS
Sbjct: 781 EQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS 840

Query: 841 LERIRAILNDTKLTDINQLPET 862
           LERIRAILNDTKLTDINQLPET
Sbjct: 841 LERIRAILNDTKLTDINQLPET 862


>gi|134152674 rabaptin, RAB GTPase binding effector protein 1
           isoform 2 [Homo sapiens]
          Length = 829

 Score = 1574 bits (4075), Expect = 0.0
 Identities = 829/862 (96%), Positives = 829/862 (96%), Gaps = 33/862 (3%)

Query: 1   MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ 60
           MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
Sbjct: 1   MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ 60

Query: 61  NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV 120
           NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
Sbjct: 61  NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV 120

Query: 121 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED 180
           MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
Sbjct: 121 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED 180

Query: 181 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV 240
           AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
Sbjct: 181 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV 240

Query: 241 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR 300
           LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
Sbjct: 241 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR 300

Query: 301 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ 360
           MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
Sbjct: 301 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ 360

Query: 361 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420
           LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK
Sbjct: 361 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420

Query: 421 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
           ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT
Sbjct: 421 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480

Query: 481 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
           PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE
Sbjct: 481 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540

Query: 541 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV 600
           KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV
Sbjct: 541 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV 600

Query: 601 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV 660
           LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV
Sbjct: 601 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV 660

Query: 661 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK 720
           SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK
Sbjct: 661 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK 720

Query: 721 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE 780
           ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQ                       
Sbjct: 721 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQ----------------------- 757

Query: 781 EQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS 840
                     ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS
Sbjct: 758 ----------ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS 807

Query: 841 LERIRAILNDTKLTDINQLPET 862
           LERIRAILNDTKLTDINQLPET
Sbjct: 808 LERIRAILNDTKLTDINQLPET 829


>gi|117956403 rabaptin, RAB GTPase binding effector protein 2 [Homo
           sapiens]
          Length = 569

 Score =  189 bits (481), Expect = 7e-48
 Identities = 189/734 (25%), Positives = 316/734 (43%), Gaps = 193/734 (26%)

Query: 136 LEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED--AEKLRSVVMPMEK 193
           LE  R+Q     E+   E++ LR  L+    E      + +  E   AE + +V    ++
Sbjct: 22  LEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE 81

Query: 194 EIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAE 253
           E+A+L+  L   +D I   EA                       +  L  ++   Q+D E
Sbjct: 82  EVASLQAIL---KDSISSYEAQ----------------------ITALKQERQQQQQDCE 116

Query: 254 KLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQV 313
           +  +EL  +  LL +     + L+   +KA++   +S++L        EIVL  E  +++
Sbjct: 117 EKERELGRLKQLLSRAYPL-DSLEKQMEKAHE---DSEKL-------REIVLPME--KEI 163

Query: 314 EELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRG 373
           EELK K                                L  EE   ++     H  S  G
Sbjct: 164 EELKAK-------------------------------LLRAEELIQEIQRRPRHAPSLHG 192

Query: 374 SVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGN 433
           S        LLP           + +D     +  + L   G   ++A  +N        
Sbjct: 193 STE------LLP-----------LSRDPSPPLEPLEELSGDGGPAAEAFAHNCD------ 229

Query: 434 LDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSV 493
                              D+AS+ S  +  G   +    ++ + ++PEQEETASL+S+ 
Sbjct: 230 -------------------DSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270

Query: 494 TQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAET 553
           T   E  Y+ P GY+LV +T+W  LQ E                                
Sbjct: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEG------------------------------- 299

Query: 554 RDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEEL 613
                      RQ    LE   +++ EL++ +++S+ED + Q+  L+ + Q SE LL  L
Sbjct: 300 -----------RQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTL 348

Query: 614 QQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----QAEDF 668
           Q  +SQA+  VQ QMA L+ + + +  E+ RL ++N  L+ +     + Q     Q E+ 
Sbjct: 349 QGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEE 408

Query: 669 ILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ 728
            LP +   L++L+   R++      A +H  E+L+ EI+ L+E ++              
Sbjct: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALE-------------- 454

Query: 729 LEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETA 788
                  EE  + +SL+ +L   + E   LE++L     ++E +Q+      EQ      
Sbjct: 455 -------EETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQ------EQ------ 495

Query: 789 AKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAIL 848
           +KA +  L+ E++ K  RLQ EL+ SEQVQRDFV+LSQ LQV+LERIRQA++LE++R+I+
Sbjct: 496 SKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIM 555

Query: 849 NDTKLTDINQLPET 862
           ++  LTD+  + +T
Sbjct: 556 DEAPLTDVRDIKDT 569



 Score =  137 bits (344), Expect = 6e-32
 Identities = 77/162 (47%), Positives = 109/162 (67%), Gaps = 1/162 (0%)

Query: 52  AKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWR 111
           A E+   ++ A  +A   +L  LR +L  A AEME +KA+A VSE+TK EA+  V+RQ +
Sbjct: 21  ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQ 80

Query: 112 EEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLE 171
           EEVASLQA++K+++  YE Q    L+QER Q  Q  E  ERE+  L++ LS     ++LE
Sbjct: 81  EEVASLQAILKDSISSYEAQI-TALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLE 139

Query: 172 NEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE 213
            +M+KA ED+EKLR +V+PMEKEI  LK KL  AE+ I+E++
Sbjct: 140 KQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQ 181



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 67/315 (21%), Positives = 120/315 (38%), Gaps = 61/315 (19%)

Query: 22  EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA 81
           E++  E  + Q+ LE   +++R + +E      ED  +Q  VL                 
Sbjct: 293 EQLQTEGRQLQKDLE-SVSRERDELQEGLRRSNEDCAKQMQVL----------------- 334

Query: 82  QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT 141
            A+++N + +    + T  +A + V+ Q  E V + + +  E  R  E    LR EQ   
Sbjct: 335 LAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQ--- 391

Query: 142 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK 201
                          L     +G ++E         Q + E L S V  +++ +   + +
Sbjct: 392 ---------------LPSSAPQGSQQE---------QGEEESLPSSVPELQQLLCCTRQE 427

Query: 202 L---TEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKE 258
                +A++   E    ++  L   LE E   R  LE  + V   +  VL+     LR E
Sbjct: 428 ARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTE 487

Query: 259 LHEVCHLLEQERQQHNQLKHTWQKANDQF------LESQRLLMRDMQRME--IVLTSEQL 310
           +  V     Q+ Q   QL     +   +       LE+   + RD  R+   + +  E++
Sbjct: 488 MERV-----QQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERI 542

Query: 311 RQVEELKKKDQEDDE 325
           RQ E L++     DE
Sbjct: 543 RQAETLEQVRSIMDE 557


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  121 bits (304), Expect = 2e-27
 Identities = 198/916 (21%), Positives = 385/916 (42%), Gaps = 105/916 (11%)

Query: 3    QPGPASQPDV-SLQQRVAELEKINAEFLRAQQQLEQEFNQ--KRAKFKELYLAK----EE 55
            + G   Q D+  +Q+   E++K  +E    Q+    +  Q  + AK +E  LA+    +E
Sbjct: 673  EAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKE 732

Query: 56   DLKRQNAVL----QAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWR 111
             L R+ A L    QA + D   L  QL    +  E +++  ++ E  +Q ++ EV +   
Sbjct: 733  ALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLES--SLFEAQQQNSVIEVTKGQL 790

Query: 112  EEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL- 170
            E         KE ++       L L+ ER+Q  Q R++A R++A   +      E++   
Sbjct: 791  EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850

Query: 171  -ENEMKKAQEDAEKLRSV-VMPMEKEIAALKDKLTEAEDKIKE----LEASKVKELNHYL 224
             E E+ + +E  EK RS     + K + +L+ +  E E ++KE    +EA + +      
Sbjct: 851  HEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERT 910

Query: 225  EAEKS-CRTDLE-------MYVAVLNTQKSVLQ--EDAEKLRKELHEVCHLLEQERQQHN 274
            +AE + C+  LE       +   +L TQK +    +  E+LR+++ +V  L EQE     
Sbjct: 911  QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM-KVQKLKEQETT--G 967

Query: 275  QLKHTWQKANDQFLESQRLLMRDMQRMEIVLTS------EQLRQVEELKKKDQEDDEQQR 328
             L+   Q+A  +  E+ R    D+  ++   +S      +  +QVE+LK +    D+ QR
Sbjct: 968  ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027

Query: 329  LNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
            L ++      +V+E+++       TQE +  Q   E E    T   +      L+L   D
Sbjct: 1028 LVEQ------EVQEKLRE------TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEAD 1075

Query: 389  PFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNL-DESDFGPLVGADS 447
               + +    +  ++ AQ         S Q + L    K K A  L  E+     + A  
Sbjct: 1076 SIRQQELSALRQDMQEAQGEQK---ELSAQMELLRQEVKEKEADFLAQEAQLLEELEASH 1132

Query: 448  VSENFDTASLGSLQMPSGFMLTK--DQERAIKAMTPEQE---------ETASLLSSVTQG 496
            ++E    ASL + +  +  +  +    E  ++A+  EQ+         + ASL S++ Q 
Sbjct: 1133 ITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192

Query: 497  MESAYVSP---SGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCS------------NYEK 541
            + S   S    SG    + + W L   +  N    L +R  + +               +
Sbjct: 1193 LGSVCESRPELSGGGDSAPSVWGLEPDQ--NGARSLFKRGPLLTALSAEAVASALHKLHQ 1250

Query: 542  QLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVL 601
             L   Q      RDQV+KL+  L     +  +   + Q+L+  + Q+ E+ S        
Sbjct: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKW------ 1304

Query: 602  RAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQG-KHSLHV 660
                     E  Q  L     ++ E MA L     +   + +  Q + + LQ  K +L  
Sbjct: 1305 ---------EGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTA 1355

Query: 661  SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAE---ILFLKEQIQAEQ 717
             ++  +  ++    +A    +L+  ED+   R+A     E++++E      L+EQ + + 
Sbjct: 1356 QVEHLQAAVVEARAQASAAGILE--EDLRTARSALKLKNEEVESERERAQALQEQGELKV 1413

Query: 718  CLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKI 777
               + L+E L L  +   E    + +L+ +++ ++ ++   ++ L   S  L+   +   
Sbjct: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVD 1473

Query: 778  SLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQ 837
              +EQ+++    ++ +E L    + + Q+L  + +   ++++D       L+ QL  + +
Sbjct: 1474 LQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK 1533

Query: 838  ADS-LERIRAILNDTK 852
             D  +E  R  + D K
Sbjct: 1534 KDQMIESQRGQVQDLK 1549



 Score =  114 bits (286), Expect = 3e-25
 Identities = 190/887 (21%), Positives = 369/887 (41%), Gaps = 91/887 (10%)

Query: 19   AELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQL 78
            AE  +++ E    Q+QL Q   ++++K++    + E +L   +  + + Q  L     Q 
Sbjct: 1278 AEKSQVHTELQDLQRQLSQN-QEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQR 1336

Query: 79   WEAQAEMENIKAIA---TVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR 135
             EAQ E E ++A     T      Q A+ E + Q     AS   +++E +R       L+
Sbjct: 1337 MEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ-----ASAAGILEEDLRTARSA--LK 1389

Query: 136  LEQERTQWAQYRESAEREIADLRRRLSEGQEEEN--LENEMKKAQEDAEKLRSVVMPMEK 193
            L+ E  +  + R  A +E  +L+    +  +E    L   + + +E+ E LR  +  +EK
Sbjct: 1390 LKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEK 1449

Query: 194  EIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAE 253
            +         E +    EL +  +K+ N  ++ ++    +LE   +VL      +QE  +
Sbjct: 1450 Q--------REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501

Query: 254  KLRKELHEVCHLLEQERQQHNQLKHTWQKAN--DQFLESQRLLMRDMQRMEIVLTSEQLR 311
            KL  +  ++  L +    Q N L+H   +    DQ +ESQR  ++D+++  + L    L 
Sbjct: 1502 KLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL- 1560

Query: 312  QVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDST 371
               EL++   + + QQ+L K  + ++   E +        L  EE S +L  +   +   
Sbjct: 1561 ---ELEENHHKMECQQKLIKELEGQR---ETQRVALTHLTLDLEERSQELQAQSSQIHDL 1614

Query: 372  RGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRR----AQSTDSLGTSGSLQSKALGY--N 425
                HS      L   D   KS  +  ++  R+     Q  +       LQ + +    +
Sbjct: 1615 ES--HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED 1672

Query: 426  YKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD----QERAIKAMTP 481
             + +    L+E                D   +       G  LT      QERA +   P
Sbjct: 1673 QRTRQTKILEE----------------DLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716

Query: 482  EQEETASL--LSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNY 539
             + +  SL  +  + +  E        +    +   + L++++     K+G    + S  
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776

Query: 540  EKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL 599
            E+++  +Q Q  E R+Q +  +  L+   D+ ++ +  + +  + ++Q  + +  Q   +
Sbjct: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV 1836

Query: 600  VLRAQASEILLE-----------ELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKD 648
              +A A +  LE           ELQ    QA+R ++E++AV    R Q  EE++   + 
Sbjct: 1837 KEKADALQGALEQAHMTLKERHGELQDHKEQARR-LEEELAV-EGRRVQALEEVLGDLRA 1894

Query: 649  NDSLQGKHSLHVSLQQAEDFILPDT-TEALR------ELVLKYREDIINVRTA----ADH 697
                Q K  L +  Q AE     +  T AL+      + VLK R+  +    A    + H
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH 1954

Query: 698  VEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQ 757
             EE  +A    L+E +       +  E+ L  + E  +   AS ++L+A L+  +    Q
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014

Query: 758  LESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQV 817
            LE  LR +  +   +Q+  +  +E +++   A A  ++ +  ++ + Q L+  L  +++V
Sbjct: 2015 LEEALRIQEGE---IQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL--AQRV 2069

Query: 818  QRDFVKLSQTL--QVQLERIRQADSLERIRAILNDTKLTDINQLPET 862
            Q + ++  Q L  + + E IR      R   +    K  +I +L ET
Sbjct: 2070 QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRET 2116



 Score =  102 bits (255), Expect = 1e-21
 Identities = 205/888 (23%), Positives = 358/888 (40%), Gaps = 109/888 (12%)

Query: 22   EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA 81
            E++ +E  RAQ  L+++   K A+ K L    +E+L      L   ++++  LR Q+ E 
Sbjct: 1393 EEVESERERAQA-LQEQGELKVAQGKAL----QENLALLTQTLAEREEEVETLRGQIQEL 1447

Query: 82   QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLE-QER 140
            + + E  KA   +       ++D  KR   +EV   Q  ++E  +      HL +  QER
Sbjct: 1448 EKQREMQKAALELL------SLDLKKRN--QEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499

Query: 141  TQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKD 200
             Q    +    RE+   R       E + LE  ++K  +  E  R  V  ++K++  L+ 
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLE--LEKKDQMIESQRGQVQDLKKQLVTLEC 1557

Query: 201  KLTEAEDKIKELEASK--VKELNHYLEAEKSCRT----DLEMYVAVLNTQKSV---LQED 251
               E E+   ++E  +  +KEL    E ++   T    DLE     L  Q S    L+  
Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617

Query: 252  AEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLR 311
            +  L +EL E    ++ +R+Q  +L+   +          + LM   +R++ VL  ++ R
Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQ-VLEDQRTR 1676

Query: 312  QVEELKKKDQEDDEQQRLNKRKDHKKADVE--------EEIKIPVVCAL-TQEESSAQLS 362
            Q + L    +ED EQ +L+ R+  ++   +        EE K P      + E     L 
Sbjct: 1677 QTKIL----EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILR 1732

Query: 363  NEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKAL 422
            ++E+ ++  +  +H L             K   +    GL R     SL  S   Q   +
Sbjct: 1733 DKEKEVECQQEHIHELQE----------LKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782

Query: 423  GYNY--KAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  +A+  G L E          S+    D A     Q        + +++  +   
Sbjct: 1783 LQQQLQEAREQGELKEQ---------SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQE 1833

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNK-------LGRRC 533
               +E A  L    +          G     + +   L++E+   G +       LG   
Sbjct: 1834 ERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLR 1893

Query: 534  DMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSS 593
                  EK L  +Q Q AE   + +     L+ +  Q +  +K++ +  + ++  S+ S 
Sbjct: 1894 AESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR 1953

Query: 594  HQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSRE---QVSEELVRLQKDND 650
            HQ  A   RA+A       LQ+ L +A   +Q +   L++  E    +      LQ   D
Sbjct: 1954 HQEEAARARAEA-------LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLD 2006

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLK--AEILF 708
            + Q  HS     +Q E+ +     E +++  L+Y+ED+  ++ A    +E+L+   E   
Sbjct: 2007 ACQA-HS-----RQLEEALRIQEGE-IQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQ 2059

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQ 768
            L E+  A++  +  ++E   L  E  +EEI  +     EL+    +K Q    LRE  Q+
Sbjct: 2060 LLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQR 2119

Query: 769  --LESL-----------QEIKI-SLEEQLKKE----TAAKATVEQLMFEEKNKAQRL--- 807
              LE+L           Q +K+ SLE +L++E     AA    E    E + KAQ L   
Sbjct: 2120 NNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179

Query: 808  --QTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKL 853
              QT+  VS   +      +  L+   E+ R  D LE  R  L   +L
Sbjct: 2180 LAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERL 2227



 Score =  101 bits (251), Expect = 3e-21
 Identities = 201/896 (22%), Positives = 380/896 (42%), Gaps = 109/896 (12%)

Query: 11   DVSLQQ-RVAELEKINA---EFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            +V LQQ ++ ELEK  +       A Q+ EQ+   +R + +EL    E+D + Q  VL+ 
Sbjct: 1471 EVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIREL----EKDRETQRNVLEH 1526

Query: 67   AQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVR 126
               +L      +   + +++++K      E    E  +        ++   Q ++KE   
Sbjct: 1527 QLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEEN-----HHKMECQQKLIKELEG 1581

Query: 127  DYEHQ----FHLRLE-QERTQWAQYRESAEREIADLRRRLSE-GQEEENLENEMKKAQED 180
              E Q     HL L+ +ER+Q  Q + S   +I DL    +   +E +  + E+K  +E 
Sbjct: 1582 QRETQRVALTHLTLDLEERSQELQAQSS---QIHDLESHSTVLARELQERDQEVKSQREQ 1638

Query: 181  AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV 240
             E+L+     + +++     +L   +++I+ LE  + ++     E  +  +  L      
Sbjct: 1639 IEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRE 1698

Query: 241  LNTQKSVLQEDAEK-------LRKELHEVCHLL---EQERQQHNQLKHTWQKANDQFLE- 289
            L TQ+ ++QE AE+        R  L  +  +L   E+E +   +  H  Q+  DQ  + 
Sbjct: 1699 LTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQ 1758

Query: 290  --------SQRLLMRDMQRMEIVLTSEQL---RQVEELKKKDQED--DEQQRLNKRKDHK 336
                     +  L+   +  EIV+  +QL   R+  ELK++  +   DE QR   ++D +
Sbjct: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQE 1818

Query: 337  KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDA------GLLLPSGDPF 390
               +++E          Q+++  Q    +E  D+ +G++           G L    +  
Sbjct: 1819 LEALQQE----------QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA 1868

Query: 391  SKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSE 450
             + + ++  +G RR Q+ + +   G L++++     + K+   L +          +   
Sbjct: 1869 RRLEEELAVEG-RRVQALEEV--LGDLRAES---REQEKALLALQQQ-----CAEQAQEH 1917

Query: 451  NFDTASL-GSLQMPSGFMLTKDQE----RAIKAMTPEQEETASLLSSVTQ---GMESAYV 502
              +T +L  S       +  +DQE    RA    +  QEE A   +   Q   G   A +
Sbjct: 1918 EVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAAL 1977

Query: 503  SPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQL-QGIQIQEAETRDQ----- 556
                  L+ + E   L + +  +   L    D C  + +QL + ++IQE E +DQ     
Sbjct: 1978 QGKEQHLLEQAE---LSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQ 2034

Query: 557  --VKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQ 614
              V++LQ  L Q +++L    + +Q LE  + Q  +++  Q      +    +   EE  
Sbjct: 2035 EDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQ-----EKQNLGQEREEEEI 2089

Query: 615  QGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTT 674
            +GL Q+ R++Q  +A     +EQ   EL   Q+ N+     HS H +    E  +  D+ 
Sbjct: 2090 RGLHQSVRELQLTLA----QKEQEILELRETQQRNNLEALPHS-HKTSPMEEQSLKLDSL 2144

Query: 675  EALRELVLKYREDIINVRTAADHVEEKLKAEILFLK-EQIQAEQCLKENLEETLQLEIEN 733
            E   +  L+  +  +  +T A  +E + KA+ L L   Q +A     + +   LQ  +  
Sbjct: 2145 EPRLQRELERLQAALR-QTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLE 2203

Query: 734  CKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEE--QLKKETAAKA 791
               E   +   + EL R  +EK +L S     + +L S  E  + L E   ++ E +   
Sbjct: 2204 RDSEQQRLQD-ELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDG 2262

Query: 792  TVEQLMFEEKNKAQRLQTELDVS-EQVQRDFVKLSQTLQVQLERIRQADSLERIRA 846
              +Q   +     Q+    L++   ++QR  V+L  TL+ Q+ER R+    E +RA
Sbjct: 2263 MEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLE-QVERERRKLKREAMRA 2317



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 196/944 (20%), Positives = 387/944 (40%), Gaps = 141/944 (14%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQ 68
            Q ++   Q   E E+  AE    Q QLE E  ++R    E  L  +++L   +  L+  +
Sbjct: 895  QTEMEAIQAQREEERTQAESALCQMQLETE--KERVSLLETLLQTQKELADASQQLERLR 952

Query: 69   DDL-----------GHLRTQLWEAQAEM--------ENIKAIATVSENTKQEAIDEVKRQ 109
             D+           G L+TQL EAQ E+        +++ A+   S +  Q+ +D  K+ 
Sbjct: 953  QDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQV 1012

Query: 110  WREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEG----- 164
              E++ S      ++ R  E +   +L +E  ++ + ++  ERE A L   L E      
Sbjct: 1013 --EDLKSQLVAQDDSQRLVEQEVQEKL-RETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069

Query: 165  ----------QEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALK-DKLTEAEDKIKELE 213
                      QE   L  +M++AQ + ++L + +  + +E+   + D L +    ++ELE
Sbjct: 1070 VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELE 1129

Query: 214  ASKVKE--LNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEK----------------L 255
            AS + E  L   L A+++    L++ +    +Q   L  + +                 L
Sbjct: 1130 ASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189

Query: 256  RKELHEVCHLLEQERQQHNQLKHTWQKANDQ----FLESQRLLMRDMQRMEIVLTSEQLR 311
            ++ L  VC    +     +     W    DQ     L  +  L+  +    +     +L 
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249

Query: 312  QVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDST 371
            Q  +L K  Q  D  +   ++ + +  D E E K  V   L  ++   QLS  +E     
Sbjct: 1250 Q--DLWKTQQTRDVLRDQVQKLEERLTDTEAE-KSQVHTEL--QDLQRQLSQNQEEKSKW 1304

Query: 372  RGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRR--AQSTDSLGTSGS---------LQSK 420
             G  +SL++ L+    +  +   + + +  L+R  AQ    L  +           LQ+ 
Sbjct: 1305 EGKQNSLESELM-ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363

Query: 421  ALGYNYKAKSAGNLDES-----DFGPLVGADSVSENFDTASL---GSLQMPSGFMLTKDQ 472
             +    +A +AG L+E          L   +  SE     +L   G L++  G  L ++ 
Sbjct: 1364 VVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENL 1423

Query: 473  ERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVS------ETEWNLLQKEVHNAG 526
                + +   +EE  +L   + +  +   +  +   L+S        E +L Q+++    
Sbjct: 1424 ALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQI---- 1479

Query: 527  NKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIK 586
                +  + C +  + L  + +QE E +  V++ Q+   + + + ++ + + Q LE   K
Sbjct: 1480 ----QELEKCRSVLEHLP-MAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKK 1534

Query: 587  -QSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVR- 644
             Q  E    Q+  L  +    E L  EL++  +  K + Q+++   ++ + +     +  
Sbjct: 1535 DQMIESQRGQVQDLKKQLVTLECLALELEE--NHHKMECQQKLIKELEGQRETQRVALTH 1592

Query: 645  ----LQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEE 700
                L++ +  LQ + S    L+     +  +  E  +E V   RE I  ++   +H+ +
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQE-VKSQREQIEELQRQKEHLTQ 1651

Query: 701  KLKA---EILFLKEQIQA--------EQCLKENLEETLQLEIENCKEEIASISSLKAELE 749
             L+    E++  KE+IQ          + L+E+LE+ ++L +     E+ +   L  E  
Sbjct: 1652 DLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQ-IKLSLRERGRELTTQRQLMQERA 1710

Query: 750  R-----IKVEKGQLEST---LREKSQQLE-------SLQEIKISLEEQLKKETAAKATVE 794
                   K ++G LE     LR+K +++E        LQE+K  LE+QL+          
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770

Query: 795  QLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQA 838
             L+ + + +   LQ +L   ++ +       Q+LQ QL+  ++A
Sbjct: 1771 LLLSQREQEIVVLQQQL---QEAREQGELKEQSLQSQLDEAQRA 1811



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 204/1014 (20%), Positives = 403/1014 (39%), Gaps = 226/1014 (22%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAV--LQAAQDDL 71
            L+Q    L ++N E    Q Q +    QK  + +EL+LA  E  + Q  +  L+A Q + 
Sbjct: 482  LEQEAWRLRRVNVEL---QLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSES 538

Query: 72   -------------GHL--------RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQW 110
                          HL        +T++  A A  E   A  + SENT +  + ++    
Sbjct: 539  LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADL---- 594

Query: 111  REEVASLQAVMKETVRDYE--HQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEE 168
            R     L A+ +    D    +Q  L+LE+E        E+AE+    L+  L+E ++  
Sbjct: 595  RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRR 654

Query: 169  --------NLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKEL 220
                    +LE +++KA+E   +L++ +  +++E   ++ KL+E+  + +E   +++++L
Sbjct: 655  EALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ-QEAATTQLEQL 713

Query: 221  NHYLEAEKSC-------RTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVC---HLLEQ-- 268
            +   + ++         +  L    A L  +   ++ D + L ++L  +     LLE   
Sbjct: 714  HQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL 773

Query: 269  -ERQQHNQL----KHTWQKANDQFLESQRLLMRDMQRMEIVLTSE-------------QL 310
             E QQ N +    K   +       +++ ++  +++ +++ L +E             QL
Sbjct: 774  FEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQL 833

Query: 311  RQVEELKK------KDQEDDEQQRLNKRKDHKKADVEEEI----------KIPVVCALTQ 354
             Q E+  K      K   + E  +L ++ + +++  ++E+          K+ +   L +
Sbjct: 834  AQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKE 893

Query: 355  EES---SAQLSNEEE-----------HLDSTRGSVHSLDAGL-----LLPSGDPFSKSDN 395
            +++   + Q   EEE            L++ +  V  L+  L     L  +     +   
Sbjct: 894  QQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQ 953

Query: 396  DMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTA 455
            DM      + Q      T+G LQ++      + K A      D   L    S        
Sbjct: 954  DM------KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS-------- 999

Query: 456  SLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEW 515
                  +    M  + Q   +K+    Q+++  L+    Q            +L    E+
Sbjct: 1000 -----SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQ-----------EKLRETQEY 1043

Query: 516  NLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAET--RDQVKKLQLMLRQANDQLEK 573
            N +QKE+      L       S  EK+ + + +QEA++  + ++  L+  +++A  + ++
Sbjct: 1044 NRIQKELEREKASL-----TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE 1098

Query: 574  TMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ 633
                 + L   +K+   D   Q + L+   +AS I  ++L+  L  A+     Q+ + ++
Sbjct: 1099 LSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL-WAQEAKAAQLQLRLR 1157

Query: 634  SREQVSEELVRLQKDNDSLQGK---HSLHVSLQQAEDFIL-------------------- 670
            S E   E L   Q+  +  Q +    SL+ +LQQA   +                     
Sbjct: 1158 STESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLE 1217

Query: 671  PD-----------------TTEALRELVLKYREDIINVRTAAD-------HVEEKL---- 702
            PD                 + EA+   + K  +D+   +   D        +EE+L    
Sbjct: 1218 PDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTE 1277

Query: 703  ------KAEILFLKEQI---QAEQCLKENLEETLQLEIENCKEEIASISS--LKAELERI 751
                    E+  L+ Q+   Q E+   E  + +L+ E+    E +AS+ S   +AEL+R+
Sbjct: 1278 AEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM 1337

Query: 752  KV--EKGQLESTLREKSQQLESLQEIKIS----------LEEQLKKETAAKATVEQLMFE 799
            +   E+  L++     + Q+E LQ   +           LEE L+   +A     + +  
Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVES 1397

Query: 800  EKNKAQRLQT--ELDVSE--QVQRDFVKLSQTLQVQLERIR----QADSLERIR 845
            E+ +AQ LQ   EL V++   +Q +   L+QTL  + E +     Q   LE+ R
Sbjct: 1398 ERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR 1451



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 160/759 (21%), Positives = 302/759 (39%), Gaps = 133/759 (17%)

Query: 141 TQWAQYRESAEREIADLRRRLS--EGQEEENLENEM---KKAQEDAEKLRSVVMPMEKEI 195
           TQ  +  E  E+ I  LR  +   E    E +E+E    + AQE+   L+ V+  + + +
Sbjct: 293 TQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVM 352

Query: 196 AALKDKLTEAEDKIKELEA-SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEK 254
               D + +       LE  S +     Y +A+K+    L +  +VL  ++  +Q+    
Sbjct: 353 VEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKA----LTLVRSVLTRRRQAVQD---- 404

Query: 255 LRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVE 314
           LR++L      +   +QQH           DQ+ E  + L + +Q++     +   + V+
Sbjct: 405 LRQQLAGCQEAVNLLQQQH-----------DQWEEEGKALRQRLQKLTGERDTLAGQTVD 453

Query: 315 ELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHL--DSTR 372
              + D    E++ L K ++  +  +E          L QE    +  N E  L  DS +
Sbjct: 454 LQGEVDSLSKERELLQKAREELRQQLE---------VLEQEAWRLRRVNVELQLQGDSAQ 504

Query: 373 GSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAG 432
           G        L L                         ++     LQ   +G   +AK + 
Sbjct: 505 GQKEEQQEELHL-------------------------AVRERERLQEMLMGL--EAKQSE 537

Query: 433 NLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSS 492
           +L E          ++ E  +++ L       G +L ++Q     A+   ++  A L SS
Sbjct: 538 SLSE--------LITLREALESSHL------EGELLRQEQTEVTAALARAEQSIAELSSS 583

Query: 493 V-TQGMESAYVSPSGYRLVSETEWNLLQK--------EVHNAGNKLGRRCDMCSNYEKQL 543
             T   E A +  +  +L +  E   L K        ++      +  R +        L
Sbjct: 584 ENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNAL 643

Query: 544 QGIQIQEAETRDQV-----KKLQLMLRQAND---QLEKTMKDKQELEDFIKQSSEDSSHQ 595
           Q + + EAE R +        L+  L++A +   +L+  ++D QE ++ I++   +S HQ
Sbjct: 644 Q-VDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ 702

Query: 596 ISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL----VRLQKDNDS 651
                      E    +L+Q   +AKR  +E +A  +Q +E +  E     VRLQ     
Sbjct: 703 ----------QEAATTQLEQLHQEAKRQ-EEVLARAVQEKEALVREKAALEVRLQAVERD 751

Query: 652 LQGKHSLHVSLQQAEDFILPDTTEALRE-LVLKYREDIINVR-TAADHVEEKLKAEILFL 709
            Q        L  A++ +     EA ++  V++  +  + V+       +E ++ E+  L
Sbjct: 752 RQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCL 811

Query: 710 KEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREK---- 765
           K ++  E+   E   +    ++   ++E       K  LE+ K    +  + LREK    
Sbjct: 812 KLELDTERSQAEQERDAAARQLAQAEQE------GKTALEQQKAAHEKEVNQLREKWEKE 865

Query: 766 --------SQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQV 817
                   ++ LESL+  K+ LE +LK++      ++    EE+ +A+    ++ +  + 
Sbjct: 866 RSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK 925

Query: 818 QRDFVKLSQT-LQVQLERIRQADSLERIRAILNDTKLTD 855
           +R  V L +T LQ Q E    +  LER+R  +   KL +
Sbjct: 926 ER--VSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 166/797 (20%), Positives = 324/797 (40%), Gaps = 107/797 (13%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKE---EDLKRQNAVL 64
            SQ   +   ++ +LE  +    R  Q+ +QE   +R + +EL   KE   +DL+R++  L
Sbjct: 1601 SQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL 1660

Query: 65   QAAQDDLGHLRTQLWE----AQAEMENIKAI-------ATVSENTKQEAIDEVKRQWREE 113
               ++ +  L  Q        + ++E IK          T      QE  +E K   + +
Sbjct: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQ 1720

Query: 114  VASLQAVMKETVRDYE-----HQFHL-RLEQERTQWAQYRE--------------SAERE 153
              SL+  MK  +RD E      Q H+  L++ + Q  Q  +                E+E
Sbjct: 1721 RGSLEH-MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQE 1779

Query: 154  IADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEA---EDKIK 210
            I  L+++L E +E+  L+ +  ++Q D  + +  +   ++E+ AL+ +  +A   E+++K
Sbjct: 1780 IVVLQQQLQEAREQGELKEQSLQSQLD--EAQRALAQRDQELEALQQEQQQAQGQEERVK 1837

Query: 211  E--------LEAS--KVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELH 260
            E        LE +   +KE +  L+  K     LE  +AV   +   L+E    LR E  
Sbjct: 1838 EKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897

Query: 261  E----VCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEEL 316
            E    +  L +Q  +Q  + +   +   D +L++Q +L    Q +E +    Q  + +E 
Sbjct: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEE 1957

Query: 317  KKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVH 376
              + + +  Q+ L K     +   E+ +      + + E S+A L   +  LD+ +    
Sbjct: 1958 AARARAEALQEALGKAHAALQGK-EQHLLEQAELSRSLEASTATL---QASLDACQAHSR 2013

Query: 377  SLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDE 436
             L+  L +  G+     D D     LR  +    L  + + + + L +  + +    L E
Sbjct: 2014 QLEEALRIQEGE---IQDQD-----LRYQEDVQQLQQALAQRDEELRHQQERE---QLLE 2062

Query: 437  SDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQG 496
                  V  + + E     +LG  +            R ++ +T  Q+E   L    TQ 
Sbjct: 2063 KSLAQRVQENMIQEK---QNLGQEREEEEIRGLHQSVRELQ-LTLAQKEQEILELRETQQ 2118

Query: 497  MESAYVSPSGYRLVSETEWNL--------LQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI 548
              +    P  ++     E +L        LQ+E+      L +       + ++ Q + +
Sbjct: 2119 RNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLAL 2178

Query: 549  QEAETRDQVKKLQ--LMLRQAN----DQLEKTMKDKQEL-EDFIKQSSEDSSHQISALVL 601
              A+T+  V  LQ   M  QA+    D  ++ ++D+ EL    +++    S    S   L
Sbjct: 2179 SLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAEL 2238

Query: 602  RAQASE-ILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKH-SLH 659
             ++  + + L E+    ++   D  E+ +   Q  E + + + RL+ D   LQ  +  L 
Sbjct: 2239 GSRGEQGVQLGEVSGVEAEPSPDGMEKQS-WRQRLEHLQQAVARLEIDRSRLQRHNVQLR 2297

Query: 660  VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEE--------------KLKAE 705
             +L+Q E        EA+R       E  I+  TA+   ++              +L+ E
Sbjct: 2298 STLEQVERERRKLKREAMRAAQAGSLE--ISKATASSPTQQDGRGQKNSDAKCVAELQKE 2355

Query: 706  ILFLKEQIQAEQCLKEN 722
            ++ L+ Q+  E+  K++
Sbjct: 2356 VVLLQAQLTLERKQKQD 2372



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 178/910 (19%), Positives = 354/910 (38%), Gaps = 124/910 (13%)

Query: 15  QQRVAEL-EKINAEFLRAQ---QQLEQEF------------NQKRAKFKELYLAKEEDLK 58
           QQR A L  K+ A+ L+ +   Q+LE+              N +     EL +  EE+ +
Sbjct: 49  QQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQ 108

Query: 59  RQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQ 118
           R  ++ +       H+       +A  E+++ + TV  +  ++ +   + QW+ E    +
Sbjct: 109 RCESLAEVNTQLRLHMEKADVVNKALREDVEKL-TVDWSRARDELMRKESQWQMEQEFFK 167

Query: 119 AVMKETVRDYEHQFHLRLEQE----RTQWAQYRESAEREIADLRR--------------R 160
             +K      EH   L L +E    R  + + + + +R++ +L+               R
Sbjct: 168 GYLKG-----EHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLR 222

Query: 161 LSEG-QEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKE 219
           L+ G Q  E   +     +E A+ L  +    E E         EA ++ +EL      +
Sbjct: 223 LTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELE--------KEAHERSQELI-----Q 269

Query: 220 LNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHT 279
           L    + EK+   D    ++ L TQ     ED EK+ K L E   +LE    +  + + +
Sbjct: 270 LKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEAS 329

Query: 280 WQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKAD 339
             +   +   S + +++D+ ++ +    E+   + +    +   +    +  + D++ AD
Sbjct: 330 LSRNAQEEKLSLQQVIKDITQVMV----EEGDNIAQGSGHENSLELDSSIFSQFDYQDAD 385

Query: 340 VEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFK 399
               +   V   LT+   + Q  +  + L   + +V+     LL    D + +    + +
Sbjct: 386 KALTL---VRSVLTRRRQAVQ--DLRQQLAGCQEAVN-----LLQQQHDQWEEEGKALRQ 435

Query: 400 DGLRRAQSTDSL-GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLG 458
              +     D+L G +  LQ +    + + +      E     L   +  +      ++ 
Sbjct: 436 RLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE 495

Query: 459 -SLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSET---E 514
             LQ  S     ++Q+  +     E+E    +L  +      +       R   E+   E
Sbjct: 496 LQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLE 555

Query: 515 WNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKT 574
             LL++E       L R     +        ++ + A+ R    KL  +        E  
Sbjct: 556 GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL-------NEAL 608

Query: 575 MKDKQELEDFIKQSSEDSSHQISALVLRAQASEIL------LEELQQGLSQAKRDVQEQM 628
             DK  L   + Q  E++    S +    QA   L       E+ ++ L +    ++ Q+
Sbjct: 609 ALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668

Query: 629 AVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDT-TEALRE-----LVL 682
               ++  ++  +L  +Q++ + +Q K S     Q+A    L     EA R+       +
Sbjct: 669 QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV 728

Query: 683 KYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETL--------------- 727
           + +E ++  + A +   + ++ +   L EQ+Q     KE LE +L               
Sbjct: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788

Query: 728 QLEIE-----NCKEEI-ASISSLKAELERIKVEKGQLESTLREKSQQL-ESLQEIKISLE 780
           QLE++       KE I   +  LK EL+    E+ Q E      ++QL ++ QE K +LE
Sbjct: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELD---TERSQAEQERDAAARQLAQAEQEGKTALE 845

Query: 781 EQLKKETAAKATVEQLMFE-EKNKAQRLQTELDVSEQVQRDFVKLSQTL---QVQLERIR 836
           +Q   + A +  V QL  + EK ++   Q      E ++R+ ++L   L   Q ++E I+
Sbjct: 846 QQ---KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902

Query: 837 QADSLERIRA 846
                ER +A
Sbjct: 903 AQREEERTQA 912


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  118 bits (296), Expect = 2e-26
 Identities = 198/865 (22%), Positives = 372/865 (43%), Gaps = 150/865 (17%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNA--------VLQ 65
            L++R+ + EK   E  +A+++L+ E    + +  EL  A+ ++LK Q A         L 
Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ-AQIDELKLQLAKKEEELQGALA 1097

Query: 66   AAQDDLGH----------LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA 115
               D+  H          L+ Q+ E Q + E        SE   +   ++ KR   EE+ 
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQEDFE--------SEKASRNKAEKQKRDLSEELE 1149

Query: 116  SLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAERE-------IADLRRRLSEGQEE- 167
            +L+  +++T+     Q  LR ++E+ + A+ +++ E E       I D+R+R +   EE 
Sbjct: 1150 ALKTELEDTLDTTAAQQELRTKREQ-EVAELKKALEEETKNHEAQIQDMRQRHATALEEL 1208

Query: 168  -ENLENEMKKAQEDAEKLRSVVMPMEKEIAA----LKDKLTEAEDKIKELEASKVKELNH 222
             E LE + K+ + + EK +  +    KE+A     L+    E+E K K+L+A +V+EL+ 
Sbjct: 1209 SEQLE-QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA-QVQELHA 1266

Query: 223  YLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK 282
             +      R +L               E A KL+ EL  V  LLE+  ++  +       
Sbjct: 1267 KVSEGDRLRVELA--------------EKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312

Query: 283  ANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELK---KKDQEDDEQQRLNKRKDHKKAD 339
               Q  ++Q LL  +  R ++ L+S ++RQ+EE K   ++ QE++E+ R N  K      
Sbjct: 1313 LESQLQDTQELLQEET-RQKLNLSS-RIRQLEEEKNSLQEQQEEEEEARKNLEKQ----- 1365

Query: 340  VEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFK 399
                     V AL      +QL++ ++ +D   G++ SL+                    
Sbjct: 1366 ---------VLAL-----QSQLADTKKKVDDDLGTIESLEEA------------------ 1393

Query: 400  DGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGS 459
               ++    D+   S  L+ KAL Y+   K+   L +      V  D   +    ++L  
Sbjct: 1394 ---KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV--ASNLEK 1448

Query: 460  LQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQ 519
             Q     +L   +E++I A   E+ + A          E+         L    E  L  
Sbjct: 1449 KQKKFDQLLA--EEKSISARYAEERDRAEA--------EAREKETKALSLARALEEALEA 1498

Query: 520  KEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQ 579
            KE     NK   R DM        + +   + +    V +L+   R    Q+E+     +
Sbjct: 1499 KEEFERQNKQ-LRADM--------EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549

Query: 580  ELEDFIKQSSEDSSH--QISALVLRAQASEILLEELQQGLSQAK---RDVQEQMAVLMQS 634
            ELED + Q++ED+    +++   ++AQ    L    +Q   + +   + V+E  A L   
Sbjct: 1550 ELEDEL-QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608

Query: 635  REQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTA 694
            R+Q +  +   +K    L+   +   +  +A D ++    + L+  +  Y+ ++   R +
Sbjct: 1609 RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK-LQAQMKDYQRELEEARAS 1667

Query: 695  ADHV-------EEKLK---AEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSL 744
             D +       E+KLK   AEIL L+E++ + +  + + E+    E +   +EI + +S 
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ----ERDELADEITNSASG 1723

Query: 745  KAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKA 804
            K+ L     EK +LE+ + +  ++LE  Q     L ++ +K T    T+   +  E++ A
Sbjct: 1724 KSALLD---EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780

Query: 805  QRLQTELDVSEQVQRDFVKLSQTLQ 829
            Q+     +  +Q++R   +L   LQ
Sbjct: 1781 QKSD---NARQQLERQNKELKAKLQ 1802



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 185/935 (19%), Positives = 387/935 (41%), Gaps = 123/935 (13%)

Query: 12   VSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFK---ELYLAKEEDLKRQNAVLQAAQ 68
            + ++++  ++E    E  R  QQL +E N    + +   EL+   EE   R  A  Q  +
Sbjct: 862  LKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELE 921

Query: 69   DDLGHLRTQLWEAQAEMENIKAIATVSENTKQEA-IDEVKRQWREEVASLQAVMKETV-- 125
            + L  L +++ E +   + ++     +E  K +A I +++ Q  EE  + Q +  E V  
Sbjct: 922  EILHDLESRVEEEEERNQILQ-----NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTA 976

Query: 126  ----RDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEE-------------- 167
                +  E +  L LE + +++ + ++  E  IA+   +L+E +E+              
Sbjct: 977  EAKIKKMEEEI-LLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM 1035

Query: 168  -ENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE---ASKVKELNHY 223
              +LE  +KK ++  ++L      ++ E   L+D++ E + +I EL+   A K +EL   
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGA 1095

Query: 224  L---EAEKSCRTDLEMYVAVLNTQKSVLQED----------AEKLRKELHEVCHLLEQER 270
            L   + E   + +    V  L  Q + LQED          AEK +++L E    L+ E 
Sbjct: 1096 LARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL 1155

Query: 271  QQHNQLKHTWQ----KANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQ 326
            +         Q    K   +  E ++ L  + +  E  +   + R    L++  ++ ++ 
Sbjct: 1156 EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQA 1215

Query: 327  QRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVH---SLDAGLL 383
            +R     +  K  +E + K         ++  A+  ++ + LD+    +H   S    L 
Sbjct: 1216 KRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275

Query: 384  LPSGDPFSKSDNDM----------FKDGLRRAQSTDSL-----GTSGSLQSKALGYNYKA 428
            +   +  SK  N++           K G++ A+   SL      T   LQ +       +
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTK----DQERAIKAMTPEQE 484
                 L+E         +   E         L + S    TK    D    I+++   ++
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395

Query: 485  ETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEK--- 541
            +      +++Q +E   ++   Y  + +T+ N LQ+E+ +    L  +  + SN EK   
Sbjct: 1396 KLLKDAEALSQRLEEKALA---YDKLEKTK-NRLQQELDDLTVDLDHQRQVASNLEKKQK 1451

Query: 542  -------QLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI--KQSSEDS 592
                   + + I  + AE RD+ +       +A ++  K +   + LE+ +  K+  E  
Sbjct: 1452 KFDQLLAEEKSISARYAEERDRAE------AEAREKETKALSLARALEEALEAKEEFERQ 1505

Query: 593  SHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-------VRL 645
            + Q+ A +    +S+  + +    L ++KR +++Q+  +    E++ +EL       +RL
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565

Query: 646  QKDNDSL--QGKHSLHVSLQQAED---FILPDTTEALRELVLKYREDIINVRTAADHVEE 700
            + +  ++  Q +  L    +Q E+    ++    E   EL     ED    R  A   ++
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL-----EDERKQRALAVASKK 1620

Query: 701  KLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLES 760
            K++ ++  L+ QI+A    ++ +       I+  ++  A +   + ELE  +  + ++ +
Sbjct: 1621 KMEIDLKDLEAQIEAANKARDEV-------IKQLRKLQAQMKDYQRELEEARASRDEIFA 1673

Query: 761  TLREKSQQLESLQEIKISLEEQLKKETAAKATVEQ----LMFEEKNKAQRLQTELDVSEQ 816
              +E  ++L+SL+   + L+E+L     A+   EQ    L  E  N A      LD   +
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733

Query: 817  VQRDFVKLSQTLQVQLERIRQADSLERIRAILNDT 851
            ++    +L + L+ +   +   +   R   +  DT
Sbjct: 1734 LEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT 1768



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 162/850 (19%), Positives = 361/850 (42%), Gaps = 93/850 (10%)

Query: 50   YLAKEEDLKRQ---NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQ-EAIDE 105
            YLA++   K+Q   +A+    ++   +L+ + W+       +K +  V+   ++ +A DE
Sbjct: 800  YLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDE 859

Query: 106  VKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLS-EG 164
               + +E+   ++  ++E  R  +HQ  L  +    +  Q       E  ++R RL+ + 
Sbjct: 860  ELLKVKEKQTKVEGELEEMER--KHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917

Query: 165  QEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYL 224
            QE E + ++++   E+ E+   ++   +K++ A    + + E+++ E E ++ K     +
Sbjct: 918  QELEEILHDLESRVEEEEERNQILQNEKKKMQA---HIQDLEEQLDEEEGARQKLQLEKV 974

Query: 225  EAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKAN 284
             AE   +  +E  + +L  Q S   ++ + +   + E    L +E ++   L     K  
Sbjct: 975  TAEAKIK-KMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNK-- 1031

Query: 285  DQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEI 344
                  Q +++ D++              E LKK+++   E ++  ++ D +  D++++I
Sbjct: 1032 ------QEVMISDLE--------------ERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071

Query: 345  --------KIPVVCALTQEESSAQLS---NEEEHLDSTRGSVHSLDAGLL---------L 384
                    ++ +  A  +EE    L+   +E  H ++    V  L A +           
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131

Query: 385  PSGDPFSKSDNDMFKD-GLRRAQSTDSLGTSGSLQ-------------SKALGYNYKAKS 430
             S +   K   D+ ++    + +  D+L T+ + Q              KAL    K   
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191

Query: 431  AGNLDESDFGPLVGADSVSENFDTAS--LGSLQMPSGFMLTKDQE-----RAIKAMTPEQ 483
            A  + +         + +SE  + A     +L+     + T ++E     + ++ +  E 
Sbjct: 1192 A-QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250

Query: 484  EETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQL 543
            E     L +  Q + +        R+    + + LQ E+ N    L         + K  
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310

Query: 544  QGIQIQEAETRDQVK---KLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV 600
              ++ Q  +T++ ++   + +L L     QLE+     QE ++  +++ ++   Q+ AL 
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370

Query: 601  LRAQASEILLEE---LQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGK-H 656
             +   ++  +++     + L +AK+ + +    L Q  E+ +    +L+K  + LQ +  
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430

Query: 657  SLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRT-AADHVEEKLKAEILFLKEQIQA 715
             L V L              L +   K+ + +   ++ +A + EE+ +AE    +++ +A
Sbjct: 1431 DLTVDLDHQR-----QVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485

Query: 716  ---EQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESL 772
                + L+E LE   + E +N K+  A +  L +  + +     +LE + R   QQ+E +
Sbjct: 1486 LSLARALEEALEAKEEFERQN-KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEM 1544

Query: 773  QEIKISLEEQLKKETAAKATVEQLMFEEKNKAQR-LQTELDVSEQVQRDFVKLSQTLQVQ 831
            +     LE++L+    AK  +E  M   K + +R LQT  + +E+ +R  +K  + L+ +
Sbjct: 1545 RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604

Query: 832  LERIRQADSL 841
            LE  R+  +L
Sbjct: 1605 LEDERKQRAL 1614



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 131/679 (19%), Positives = 281/679 (41%), Gaps = 78/679 (11%)

Query: 12   VSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDL 71
            ++L  R+ +LE+     L+ QQ+ E+E  +   K      ++  D K++        DDL
Sbjct: 1332 LNLSSRIRQLEE-EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK------VDDDL 1384

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAI-----DEVKRQWREEVASL------QAV 120
            G + + L EA+ ++  +K    +S+  +++A+     ++ K + ++E+  L      Q  
Sbjct: 1385 GTIES-LEEAKKKL--LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQ 1441

Query: 121  MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLR----------RRLSEGQE-EEN 169
            +   +   + +F   L +E++  A+Y E  +R  A+ R          R L E  E +E 
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE 1501

Query: 170  LENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKS 229
             E + K+ + D E L S    + K +  L+      E +++E+  ++++EL   L+A + 
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR-TQLEELEDELQATED 1560

Query: 230  CRTDLEMYVAVLNTQ-----KSVLQEDAEKLR---KELHEVCHLLEQERQQHNQLKHTWQ 281
             +  LE+ +  +  Q     ++  +++ EK R   K++ E+   LE ER+Q         
Sbjct: 1561 AKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ--------- 1611

Query: 282  KANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVE 341
                     + L +   ++MEI L   + +     K +D+   + ++L  +    + ++E
Sbjct: 1612 ---------RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662

Query: 342  EEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDG 401
            E          +++E  AQ    E+ L S    +  L   L   +    ++   +  +D 
Sbjct: 1663 E-------ARASRDEIFAQSKESEKKLKSLEAEILQLQEEL---ASSERARRHAEQERDE 1712

Query: 402  LRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQ 461
            L    +  + G S  L  K       A+    L+E      +  D   +        + +
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772

Query: 462  MPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGY--RLVSETEWNLLQ 519
            + +     +  + A + +  + +E  + L  +   ++S + +        + + E  L Q
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832

Query: 520  KEVHNAG-NKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDK 578
            +    A  NKL RR       EK+L+ I +Q  + R    + +  + +AN ++++  +  
Sbjct: 1833 EAKERAAANKLVRRT------EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQL 1886

Query: 579  QELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQV 638
            +E E+   +++         L    +A+E L  E+    ++ +R      +     R Q+
Sbjct: 1887 EEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQL 1946

Query: 639  SEELVRLQKDNDSLQGKHS 657
              E   L+  +D  + K S
Sbjct: 1947 HLEGASLELSDDDTESKTS 1965



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 78/370 (21%), Positives = 155/370 (41%), Gaps = 46/370 (12%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEE----DLKRQNAV 63
            +Q +  LQ R  + E+     ++  ++LE E   +R K + L +A ++    DLK   A 
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER-KQRALAVASKKKMEIDLKDLEAQ 1632

Query: 64   LQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWRE------EVASL 117
            ++AA      +  QL + QA+M++ +     +  ++ E   + K   ++      E+  L
Sbjct: 1633 IEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQL 1692

Query: 118  QAVMKETVRDYEHQFHLRLEQERTQWAQY---RESAEREIADLRRRLSE--GQEEENLEN 172
            Q  +  + R   H      EQER + A       S +  + D +RRL     Q EE LE 
Sbjct: 1693 QEELASSERARRHA-----EQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE 1747

Query: 173  EMKKAQEDAEKLRSVVMPMEK---EIAA--------------LKDKLTEAEDKIKELEAS 215
            E    +   ++ R   + ++    E+AA              L+ +  E + K++ELE +
Sbjct: 1748 EQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGA 1807

Query: 216  KVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQ 275
               +    + A ++    LE  +     +++   +   +  K+L E+   +E ER+  +Q
Sbjct: 1808 VKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQ 1867

Query: 276  LKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH 335
             K   +KAN +        M+ ++R       E  R     +K  +E D+    N+    
Sbjct: 1868 YKEQMEKANAR--------MKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSR 1919

Query: 336  KKADVEEEIK 345
            + + ++  ++
Sbjct: 1920 EVSTLKNRLR 1929



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 28/126 (22%), Positives = 59/126 (46%), Gaps = 3/126 (2%)

Query: 724 EETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQL 783
           EE LQ + E   +     + ++ ELE ++ +  QL       ++QL++  E+    EE  
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910

Query: 784 KKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQL---ERIRQADS 840
            +  A K  +E+++ + +++ +  +    + +  ++      Q L+ QL   E  RQ   
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970

Query: 841 LERIRA 846
           LE++ A
Sbjct: 971 LEKVTA 976


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  112 bits (279), Expect = 2e-24
 Identities = 185/902 (20%), Positives = 367/902 (40%), Gaps = 98/902 (10%)

Query: 16   QRVAELEKINAEFLRAQQQLEQEFNQKRAKFK--ELYLAKEEDLKRQNAVLQAAQDDLGH 73
            +R  E E+INAE    +++LE E ++ +      EL LAK E  K       A ++ + +
Sbjct: 927  ERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH------ATENKVKN 980

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFH 133
            L  ++      +  +       + T Q+ +D+++ +  E+  ++    K  +        
Sbjct: 981  LTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAE--EDKVNILTKAKTKLEQQVDDLE 1038

Query: 134  LRLEQERTQWAQYRESAEREIADLRRRLSEGQEEE-NLENEMKKAQEDAEKLRSVVMPME 192
              LEQE+    + R   ER    L   L   QE   ++EN+ ++  E  EK    +  + 
Sbjct: 1039 GSLEQEK----KLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLI 1094

Query: 193  KEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDA 252
             +I   +    + + KIKEL+A +++EL   +EAE++ R   E   + L+ +   + E  
Sbjct: 1095 SKIEDEQAVEIQLQKKIKELQA-RIEELGEEIEAERASRAKAEKQRSDLSRELEEISERL 1153

Query: 253  EKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQ 312
            E+          L ++   +  +L+   ++A  Q  E+    +R      +    EQ+  
Sbjct: 1154 EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQH-EAMVAALRKKHADSMAELGEQIDN 1212

Query: 313  VEELKKKDQEDDEQQRLNKRKDHKKADVEEEIK--IPVVCALTQEESSAQLSNEEEHLDS 370
            ++ +K+K +++  + ++        A+   + K  +  +C   +++ S +L  +EE    
Sbjct: 1213 LQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVS-ELKTKEEEQQR 1271

Query: 371  TRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKS 430
                + +  A L   +G+   + D    KD L    S     ++  ++        + K+
Sbjct: 1272 LINDLTAQRARLQTEAGEYSRQLDE---KDALVSQLSRSKQASTQQIEELKHQLEEETKA 1328

Query: 431  AGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFML---------TKDQERAIKAMTP 481
               L  +        D + E ++    G  ++               TK +  AI+  T 
Sbjct: 1329 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR-TE 1387

Query: 482  EQEETASLLSSVTQGMES---------AYVSPSGYRLVSETEWNLLQKEVHNAG----NK 528
            E EE    L+   Q  E          A +  +  RL +E E  +L  E  NA     +K
Sbjct: 1388 ELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDK 1447

Query: 529  LGRRCDMC-----SNYEKQLQGIQIQEAETRD---QVKKLQLMLRQANDQLEKTMKD--- 577
              R  D         YE+    ++  + E+R    ++ K++ +  ++ DQLE   ++   
Sbjct: 1448 KQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKN 1507

Query: 578  -KQELEDFIKQSSEDSS--HQISALVLRAQAS----EILLEELQQGLSQAKRDVQEQMAV 630
             +QE+ D  +Q +E     H++  +  + +      +  LEE +  L   +  +      
Sbjct: 1508 LQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLE 1567

Query: 631  LMQSREQVSEELVRLQKDNDSLQGKHSLHV-SLQQAEDFILPDTTEALRELVLKYREDII 689
            L Q + +V  ++    ++ D L+  H+  V ++Q   D  +    +ALR  V K  E  +
Sbjct: 1568 LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALR--VKKKMEGDL 1625

Query: 690  NV---------RTAADHVEEK------LKAEILFLKEQIQAEQCLKENLE------ETLQ 728
            N          R AA+ +         LK   L L + ++ ++ LKE L         LQ
Sbjct: 1626 NEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQ 1685

Query: 729  LEIENC---------KEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISL 779
             EIE             +IA    L A  ER+++   Q  S +  K +    + +++  +
Sbjct: 1686 AEIEELWATLEQTERSRKIAEQELLDAS-ERVQLLHTQNTSLINTKKKLENDVSQLQSEV 1744

Query: 780  EEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQAD 839
            EE +++   A+   ++ + +    A+ L+ E D S  ++R    L QT++    R+ +A+
Sbjct: 1745 EEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1804

Query: 840  SL 841
             L
Sbjct: 1805 QL 1806



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 173/885 (19%), Positives = 365/885 (41%), Gaps = 97/885 (10%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQ---QLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQ 65
            Q D  L+++  E+  + ++    Q    QL+++  + +A+ +EL     E+++ + A   
Sbjct: 1078 QLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEEL----GEEIEAERASRA 1133

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAI--ATVSENTKQEAIDEVKRQWREEVASLQAVMKE 123
             A+     L  +L E    +E       A V  N K+EA  +  R+  EE       M  
Sbjct: 1134 KAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVA 1193

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEK 183
             +R         L ++     + ++  E+E ++L+       E ++L +  +   +    
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELK------METDDLSSNAEAISKAKGN 1247

Query: 184  LRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNT 243
            L  +   +E +++ LK K  E +  I +L A + +      E  +    + +  V+ L+ 
Sbjct: 1248 LEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQL-DEKDALVSQLSR 1306

Query: 244  QKSVLQEDAEKLRKELHE-------VCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMR 296
             K    +  E+L+ +L E       + H L+  R   + L+  +++  +   E QR L +
Sbjct: 1307 SKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1366

Query: 297  ---DMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
               ++ +      ++ +++ EEL++  ++    QRL + ++H +A       +   CA +
Sbjct: 1367 ANSEVAQWRTKYETDAIQRTEELEEAKKK--LAQRLQEAEEHVEA-------VNAKCA-S 1416

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
             E++  +L NE E L       ++  A L     D   ++ + +  +  ++ + T +   
Sbjct: 1417 LEKTKQRLQNEVEDLMLDVERSNAACAAL-----DKKQRNFDKVLSEWKQKYEETQAELE 1471

Query: 414  SGSLQSKALGYN-YKAKSAGNLDESDFGPLVGADSVSENFDTA-SLGSLQMPSGFMLTKD 471
            +   +S++L    +K K   N+ E     L      ++N     S  + Q+  G     +
Sbjct: 1472 ASQKESRSLSTELFKVK---NVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHE 1528

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGR 531
             E+  K +  E+ E  + L      +E       G  L  + E N ++ EV     +   
Sbjct: 1529 LEKIKKQVEQEKCEIQAALEEAEASLEHE----EGKILRIQLELNQVKSEVDRKIAEKDE 1584

Query: 532  RCDMCS-NYEKQLQGIQIQ-EAETRDQ-----VKK--------LQLMLRQANDQLEKTMK 576
              D    N+ + ++ +Q   +AE R +     VKK        +++ L  AN    ++++
Sbjct: 1585 EIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLR 1644

Query: 577  DKQELEDFIKQSS----------EDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQE 626
            + +  +  +K++           ED   Q++ +  RA   +  +EEL   L Q +R  + 
Sbjct: 1645 NYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRK- 1703

Query: 627  QMAVLMQSREQVSEELVRLQKDNDSL-QGKHSLHVSLQQAEDFILPDTTEALRELVLKYR 685
               +  Q     SE +  L   N SL   K  L   + Q +  +  +  +  R    K +
Sbjct: 1704 ---IAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEV-EEVIQESRNAEEKAK 1759

Query: 686  EDIINVRTAADHV--EEKLKAEILFLKEQI-QAEQCLKENLEETLQLEIENCKEEIASIS 742
            + I +    A+ +  E+   A +  +K+ + Q  + L+  L+E  QL ++  K++I  + 
Sbjct: 1760 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1819

Query: 743  SLKAELERIKVEKGQLESTLREKSQQLESL-------QEIKISLEEQLKKETAAKATVEQ 795
            +   ELE      G++E+  +  ++ ++ L       +E+    EE  K     +  V++
Sbjct: 1820 ARVRELE------GEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDK 1873

Query: 796  LMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS 840
            L  + K+  ++ +   + S      F KL   L+   ER   A+S
Sbjct: 1874 LQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAES 1918



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 161/832 (19%), Positives = 325/832 (39%), Gaps = 102/832 (12%)

Query: 57   LKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEA-IDEVKRQWREEVA 115
            L+R+ A+     +    +  + W        IK +   +E  K+ A + E  ++ ++E+A
Sbjct: 808  LQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELA 867

Query: 116  SLQAVMKE------TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEEN 169
              +A  KE      T+   ++   L+++ E    A   E  E+ I          + +  
Sbjct: 868  KSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLI----------KNKIQ 917

Query: 170  LENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE--ASKVKELNHYLEAE 227
            LE ++K+  E AE+   +   +  +   L+D+ +E +  I +LE   +KV++  H  E +
Sbjct: 918  LEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 977

Query: 228  KSCRTD----LEMYVAVLNTQKSVLQEDAE---------------------KLRKELHEV 262
                T+    L+  +A L+ +K  LQE  +                     KL +++ ++
Sbjct: 978  VKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDL 1037

Query: 263  CHLLEQERQQHNQLKHTWQKANDQFLESQRLLM---RDMQRMEIVLTSEQLRQVEELKKK 319
               LEQE++    L+   +K       +Q   M    D Q+++  L  ++      + K 
Sbjct: 1038 EGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKI 1097

Query: 320  DQEDDEQQRLNKRKDHKKADVE---EEIKIPVVCALTQEESSAQLSNEEEHLD---STRG 373
            + E   + +L K+    +A +E   EEI+         E+  + LS E E +       G
Sbjct: 1098 EDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1157

Query: 374  SVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGN 433
               S    L       F K   D+                  +LQ +A+    + K A +
Sbjct: 1158 GATSAQVELNKKREAEFQKLRRDL---------------EEATLQHEAMVAALRKKHADS 1202

Query: 434  LDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSV 493
            + E           + E  D       ++       + ++  +K  T +    A  +S  
Sbjct: 1203 MAE-----------LGEQIDNLQRVKQKL-------EKEKSELKMETDDLSSNAEAISKA 1244

Query: 494  TQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAET 553
               +E    S        +T+    Q+ +++   +  R       Y +QL     ++   
Sbjct: 1245 KGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLD----EKDAL 1300

Query: 554  RDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEEL 613
              Q+ + +    Q  ++L+  ++++ + ++ +  + + S H    L  + +  +    EL
Sbjct: 1301 VSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL 1360

Query: 614  QQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDT 673
            Q+ LS+A  +V +          Q +EEL   +K       +   HV    A+   L  T
Sbjct: 1361 QRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKT 1420

Query: 674  TEALRELVLKYREDIINVRTAADHVE------EKLKAEILFLKEQIQAEQCLKENLEETL 727
             + L+  V     D+     A   ++      +K+ +E     E+ QAE    +    +L
Sbjct: 1421 KQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSL 1480

Query: 728  QLEIENCK----EEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQL 783
              E+   K    E +  + +L+ E + ++ E   L   + E  +Q+  L++IK  +E++ 
Sbjct: 1481 STELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEK 1540

Query: 784  KKETAAKATVEQLMFEEKNKAQRLQTELD-VSEQVQRDFVKLSQTLQVQLER 834
             +  AA    E  +  E+ K  R+Q EL+ V  +V R   +  + +  QL+R
Sbjct: 1541 CEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID-QLKR 1591



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 78/365 (21%), Positives = 179/365 (49%), Gaps = 48/365 (13%)

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
            +E E   +++E     ++L +        E+++  +  ++ + + QV+     L  A ++
Sbjct: 848  TEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEER 907

Query: 571  LEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAV 630
             E+ +K+K +LE  IK+ +E +  +               EE+   L+  KR ++++ + 
Sbjct: 908  CEQLIKNKIQLEAKIKEVTERAEEE---------------EEINAELTAKKRKLEDECSE 952

Query: 631  LMQSREQVSEELVRLQKDNDSLQGK-HSLHVSLQQAEDFI--LPDTTEALREL------V 681
            L +  + +   L +++K+  + + K  +L   +   ++ I  L    +AL+E        
Sbjct: 953  LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012

Query: 682  LKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEET---LQLEIENCKEEI 738
            L+  ED +N+ T A   + KL+ ++  L+  ++ E+ L+ +LE     L+ +++  +E  
Sbjct: 1013 LQAEEDKVNILTKA---KTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQEST 1069

Query: 739  ASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMF 798
              + + K +L+  K+EK + E  +     ++E  Q ++I L++++K+    +A +E+L  
Sbjct: 1070 MDMENDKQQLDE-KLEKKEFE--ISNLISKIEDEQAVEIQLQKKIKE---LQARIEELGE 1123

Query: 799  E-EKNKAQRLQTELDVSEQVQRDFVKLSQTL---------QVQLERIRQADSLERIRAIL 848
            E E  +A R + E   S+ + R+  ++S+ L         QV+L + R+A+  +++R  L
Sbjct: 1124 EIEAERASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQVELNKKREAE-FQKLRRDL 1181

Query: 849  NDTKL 853
             +  L
Sbjct: 1182 EEATL 1186


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  111 bits (277), Expect = 3e-24
 Identities = 198/913 (21%), Positives = 368/913 (40%), Gaps = 113/913 (12%)

Query: 19   AELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQL 78
            AE E++ A     +Q+LE+  +   A+ +E    +EE  +   A  +  Q ++  L  QL
Sbjct: 897  AEAEELRARLTAKKQELEEICHDLEARVEE----EEERCQHLQAEKKKMQQNIQELEEQL 952

Query: 79   WEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQ 138
             E ++  + ++ +  V+   K + ++E +    ++   L A  K+ + D   +F   L +
Sbjct: 953  EEEESARQKLQ-LEKVTTEAKLKKLEEEQIILEDQNCKL-AKEKKLLEDRIAEFTTNLTE 1010

Query: 139  ERTQ---WAQYRESAEREIADLRRRLS-EGQEEENLENEMKKAQEDAEKLRSVVMPMEKE 194
            E  +    A+ +   E  I DL  RL  E ++ + LE   +K + D+  L   +  ++ +
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070

Query: 195  IAALKDKLTEAED---------------------KIKELEASKVKELNHYLEAEKSCRTD 233
            IA LK +L + E+                     KI+ELE S++ EL   LE+E++ R  
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE-SQISELQEDLESERASRNK 1129

Query: 234  LEMYVAVLNTQKSVLQEDAEKLRKELHEVC-------HLLEQERQQHNQLKHTWQKANDQ 286
             E        QK  L E+ E L+ EL +          L  +  Q+ N LK T ++    
Sbjct: 1130 AEK-------QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182

Query: 287  FLESQRLLMRDMQRMEIVLTSEQLRQVEELK------KKDQEDDEQQRLNKRK------- 333
              E+Q   MR      +   +EQL Q + +K      K+  E++  +  N+ K       
Sbjct: 1183 H-EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKG 1241

Query: 334  --DHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFS 391
              +HK+  VE +++   V     E    +L+++   L     +V     GLL  S    S
Sbjct: 1242 DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV----TGLLSQSDSKSS 1297

Query: 392  KSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSEN 451
            K   D F     + Q T  L    + Q  +L  + K K   +   S    L   +    N
Sbjct: 1298 KLTKD-FSALESQLQDTQELLQEENRQKLSL--STKLKQVEDEKNSFREQLEEEEEAKHN 1354

Query: 452  FDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSP-SGYRLV 510
             +   + +L      M  K ++          EE    L    +G+   +    + Y  +
Sbjct: 1355 LEK-QIATLHAQVADMKKKMEDSV--GCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKL 1411

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
             +T+  L Q+E+ +    L  +     N EK+ +      AE     K +     +  D+
Sbjct: 1412 EKTKTRL-QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE----KTISAKYAEERDR 1466

Query: 571  LEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAV 630
             E   ++K+     + ++ E++  Q + L    +     +E+L        + V E    
Sbjct: 1467 AEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKS 1526

Query: 631  LMQSREQVSEELVRLQKDNDSLQG----KHSLHVSLQQAEDFILPDTTEALRELVLKYRE 686
                 +QV E   +L++  D LQ     K  L V+LQ  +     D      +   K ++
Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ 1586

Query: 687  DIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKA 746
             +  VR     +E++ K   + +  + + E  LK+ LE  +    +N  E I  +  L+A
Sbjct: 1587 LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD-LEAHIDSANKNRDEAIKQLRKLQA 1645

Query: 747  -------ELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQ---- 795
                   EL+  +  + ++ +  +E  ++L+S++   I L+E+L     AK   +Q    
Sbjct: 1646 QMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDE 1705

Query: 796  -------------LMFEEKNKAQ----RLQTELDVSEQVQRDFVK-LSQTLQVQLERIRQ 837
                         L  EEK + +    +L+ EL+  EQ   + +    +   +Q+++I  
Sbjct: 1706 LADEIANSSGKGALALEEKRRLEARIAQLEEELE-EEQGNTELINDRLKKANLQIDQINT 1764

Query: 838  ADSLERIRAILND 850
              +LER  A  N+
Sbjct: 1765 DLNLERSHAQKNE 1777



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 155/703 (22%), Positives = 289/703 (41%), Gaps = 132/703 (18%)

Query: 171  ENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSC 230
            E EM   +E+  K+R      EK++AA +++LTE E    +L A K+ +L   L+AE   
Sbjct: 844  EEEMMAKEEELVKVR------EKQLAA-ENRLTEMETLQSQLMAEKL-QLQEQLQAETEL 895

Query: 231  RTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLES 290
              + E   A L  +K  L+E    L   + E     E+ER QH Q +    + N Q LE 
Sbjct: 896  CAEAEELRARLTAKKQELEEICHDLEARVEE-----EEERCQHLQAEKKKMQQNIQELEE 950

Query: 291  QRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVC 350
            Q   + + +     L  E++    +LKK ++E    +  N +   +K  +E+ I      
Sbjct: 951  Q---LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA----- 1002

Query: 351  ALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDS 410
                 E +  L+ EEE   S     +  +A +             D+ ++ LRR +    
Sbjct: 1003 -----EFTTNLTEEEEKSKSLAKLKNKHEAMI------------TDL-EERLRREEK--- 1041

Query: 411  LGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTK 470
                   Q + L    +     + D SD         ++E    A +  L+M     L K
Sbjct: 1042 -------QRQELEKTRRKLEGDSTDLSD--------QIAEL--QAQIAELKM----QLAK 1080

Query: 471  DQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLG 530
             +E    A+   +EE A                          + N+  K++    +++ 
Sbjct: 1081 KEEELQAALARVEEEAA--------------------------QKNMALKKIRELESQIS 1114

Query: 531  RRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKT-----MKDKQELE-DF 584
               ++  + E +       E + RD  ++L+ +  +  D L+ T     ++ K+E E + 
Sbjct: 1115 ---ELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVR 644
            +K++ E+           A+  E  ++E++Q  SQA  ++ EQ+    + +  + +    
Sbjct: 1172 LKKTLEEE----------AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221

Query: 645  LQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKA 704
            L+ +   L  +  + +  +   +         L+EL +K+ E    VRT       KL+ 
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG-ERVRTELADKVTKLQV 1280

Query: 705  EI-----LFLKEQIQAEQCLKE--NLEETLQLEIENCKEEIASISSLKAELERIKVEKGQ 757
            E+     L  +   ++ +  K+   LE  LQ   E  +EE     SL  +L++++ EK  
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340

Query: 758  LESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQV 817
                     +QLE  +E K +LE+Q+    A  A +++ M   ++    L+T  +V  ++
Sbjct: 1341 FR-------EQLEEEEEAKHNLEKQIATLHAQVADMKKKM---EDSVGCLETAEEVKRKL 1390

Query: 818  QRDFVKLSQTLQVQLERIRQADSLERIRAILN---DTKLTDIN 857
            Q+D   LSQ  +   E++   D LE+ +  L    D  L D++
Sbjct: 1391 QKDLEGLSQRHE---EKVAAYDKLEKTKTRLQQELDDLLVDLD 1430



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 166/915 (18%), Positives = 351/915 (38%), Gaps = 145/915 (15%)

Query: 14   LQQRVAELEKINAEFLRAQQQLE----------QEFNQKRAKFKELYLAKEEDLKRQNAV 63
            L++R+   EK   E  + +++LE           E   + A+ K     KEE+L+   A 
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALAR 1091

Query: 64   LQ--AAQDDLG-----HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS 116
            ++  AAQ ++       L +Q+ E Q ++E        SE   +   ++ KR   EE+ +
Sbjct: 1092 VEEEAAQKNMALKKIRELESQISELQEDLE--------SERASRNKAEKQKRDLGEELEA 1143

Query: 117  LQAVMKETVRDYEHQFHLRLEQE------RTQWAQYRESAEREIADLRRRLSEGQEE--E 168
            L+  +++T+     Q  LR ++E      +    +  ++ E +I ++R++ S+  EE  E
Sbjct: 1144 LKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAE 1203

Query: 169  NLENEMKKAQEDAEKLRSVVM----PMEKEIAALKDKLTEAEDKIKELEASKVKELNHYL 224
             LE + K+ + + EK +  +      +  E+  L     ++E K K++EA +++EL    
Sbjct: 1204 QLE-QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEA-QLQELQVKF 1261

Query: 225  EAEKSCRTDLEMYVAVL--------------NTQKSVLQEDAEKLRKELHEVCHLLEQER 270
               +  RT+L   V  L              +++ S L +D   L  +L +   LL++E 
Sbjct: 1262 NEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN 1321

Query: 271  QQHNQLKHTWQKANDQF------LESQRLLMRDMQRMEIVLTSEQ-------------LR 311
            +Q   L    ++  D+       LE +     ++++    L ++              L 
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381

Query: 312  QVEELKKKDQEDDEQQRLNKRKDHK----------KADVEEEIKIPVVCALTQEESSAQL 361
              EE+K+K Q+D E   L++R + K          K  +++E+   +V    Q +S+  L
Sbjct: 1382 TAEEVKRKLQKDLEG--LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439

Query: 362  SNEE------------------EHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLR 403
              ++                  E  D         +   L  +       +     + L 
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499

Query: 404  RAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMP 463
            +   T+      S        +   KS   L++         + + +         L++ 
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559

Query: 464  SGFMLTKDQ-ERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEV 522
                  K Q ER ++    + EE    L    + ME+        R ++      L+ ++
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDL 1619

Query: 523  HNAGNKLGRRCDMCSNYEKQLQGIQIQE------------------AETRDQVKKLQLM- 563
             +    +           KQL+ +Q Q                   A+ ++  KKL+ M 
Sbjct: 1620 KDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSME 1679

Query: 564  --LRQANDQL---EKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLS 618
              + Q  ++L   E+  +  Q+  D +     +SS + +  +   +  E  + +L++ L 
Sbjct: 1680 AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELE 1739

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALR 678
            + + +            E +++ L +     D +    +L  S  Q  +          +
Sbjct: 1740 EEQGNT-----------ELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK 1788

Query: 679  ELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEI 738
            EL +K +E    V++        L+A+I  L+EQ+  E   ++   + ++   +  K+ +
Sbjct: 1789 ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVL 1848

Query: 739  ASISSLKAELERIKVEKGQLESTLREKSQQLESLQE-------IKISLEEQLKKETAAKA 791
              +   +   E+ K +  +  + L++  +QLE  +E        +  L+ +L+  T    
Sbjct: 1849 LQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETAD 1908

Query: 792  TVEQLMFEEKNKAQR 806
             + + +   KNK +R
Sbjct: 1909 AMNREVSSLKNKLRR 1923



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 162/797 (20%), Positives = 320/797 (40%), Gaps = 122/797 (15%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAK---EEDLKRQNAVL 64
            SQ    L +++ + +++ A   +A+Q LE E  +   + K L   K   E   K+  A L
Sbjct: 1195 SQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL 1254

Query: 65   QAAQ---DDLGHLRTQLWEA----QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASL 117
            Q  Q   ++   +RT+L +     Q E++N+  + + S++   +          ++ ++L
Sbjct: 1255 QELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLT--------KDFSAL 1306

Query: 118  QAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKA 177
            ++ +++T             QE  Q         R+   L  +L + ++E+N   E  + 
Sbjct: 1307 ESQLQDT-------------QELLQ------EENRQKLSLSTKLKQVEDEKNSFREQLEE 1347

Query: 178  QEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMY 237
            +E+A+        +EK+IA L  ++ + + K+++     V  L    E ++  + DLE  
Sbjct: 1348 EEEAKH------NLEKQIATLHAQVADMKKKMED----SVGCLETAEEVKRKLQKDLE-G 1396

Query: 238  VAVLNTQKSVLQEDAEK----LRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 293
            ++  + +K    +  EK    L++EL ++   L+ +RQ    L+   QK  DQ L  ++ 
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK-QKKFDQLLAEEKT 1455

Query: 294  LM------RDMQRMEI-VLTSEQLRQVEELKKKDQEDDEQQRLNKR-----------KDH 335
            +       RD    E     ++ L     L++  ++  E +RLNK+           KD 
Sbjct: 1456 ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDD 1515

Query: 336  KKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLL---------LPS 386
                V E  K         EE   QL   E+ L +T  +   L+  L          L  
Sbjct: 1516 VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575

Query: 387  GDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGAD 446
             D  S+         +R  ++   L      +S A+     A+    +D  D    +  D
Sbjct: 1576 RDEQSEEKKKQLVRQVREMEA--ELEDERKQRSMAVA----ARKKLEMDLKDLEAHI--D 1627

Query: 447  SVSENFDTA--SLGSLQ-MPSGFMLTKDQERA----IKAMTPEQEETASLLSSVTQGMES 499
            S ++N D A   L  LQ      M   D  RA    I A   E E+    + +    ++ 
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687

Query: 500  AYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKK 559
               +    +  ++ E + L  E+ N+  K     +     E ++  ++ +  E +   + 
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL 1747

Query: 560  LQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQ 619
            +   L++AN Q+++   D   LE    Q +E++  Q+       + ++ L  +LQ+    
Sbjct: 1748 INDRLKKANLQIDQINTD-LNLERSHAQKNENARQQLE------RQNKELKVKLQEMEGT 1800

Query: 620  AKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRE 679
             K   +  +  L     Q+ E+L     DN++ +         +QA    +  T + L++
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQL-----DNETKE---------RQAACKQVRRTEKKLKD 1846

Query: 680  LVLKYREDIINVRTAADHVE------EKLKAEILFLKEQIQAEQCLKENLEETLQLEIEN 733
            ++L+  ++  N     D  +      ++LK ++   +E+ Q     +  L+  L+   E 
Sbjct: 1847 VLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATET 1906

Query: 734  CKEEIASISSLKAELER 750
                   +SSLK +L R
Sbjct: 1907 ADAMNREVSSLKNKLRR 1923



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 76/366 (20%), Positives = 155/366 (42%), Gaps = 25/366 (6%)

Query: 512  ETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQL 571
            ET  + L  E      +L    ++C+  E+    +  ++ E  +    L+  + +  ++ 
Sbjct: 872  ETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERC 931

Query: 572  EKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVL 631
            +    +K++++  I++  E    + SA   + Q  ++  E   + L + +  +++Q   L
Sbjct: 932  QHLQAEKKKMQQNIQELEEQLEEEESARQ-KLQLEKVTTEAKLKKLEEEQIILEDQNCKL 990

Query: 632  MQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINV 691
             + ++ + + +     +    + K      L+   + ++ D  E LR    K R+++   
Sbjct: 991  AKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREE-KQRQELEKT 1049

Query: 692  RTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS----------- 740
            R   +     L  +I  L+ QI   +      EE LQ  +   +EE A            
Sbjct: 1050 RRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL 1109

Query: 741  ---ISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLM 797
               IS L+ +LE  +  + + E   R+  ++LE+L   K  LE+ L   TAA+  +    
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEAL---KTELEDTL-DSTAAQQELRSKR 1165

Query: 798  FEEKNKAQR-LQTELDVSE-QVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTD 855
             +E N  ++ L+ E    E Q+Q    K SQ ++   E++ Q    +R++A L   K T 
Sbjct: 1166 EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQT---KRVKANLEKAKQTL 1222

Query: 856  INQLPE 861
             N+  E
Sbjct: 1223 ENERGE 1228



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 51/209 (24%), Positives = 97/209 (46%), Gaps = 25/209 (11%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQ---EFNQKRAKFKELYLAKEEDLKRQNAVL 64
            +Q +  L++     E IN    +A  Q++Q   + N +R+  ++   A+++ L+RQN   
Sbjct: 1732 AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ-LERQNK-- 1788

Query: 65   QAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKET 124
                     L+ +L E +     +K+    S    +  I +++ Q   E    QA  K+ 
Sbjct: 1789 --------ELKVKLQEMEG---TVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQ- 1836

Query: 125  VRDYEHQFH---LRLEQERTQWAQYRESAER---EIADLRRRLSEGQEEENLEN-EMKKA 177
            VR  E +     L+++ ER    QY++ A++    +  L+R+L E +EE    N   +K 
Sbjct: 1837 VRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896

Query: 178  QEDAEKLRSVVMPMEKEIAALKDKLTEAE 206
            Q + E        M +E+++LK+KL   +
Sbjct: 1897 QRELEDATETADAMNREVSSLKNKLRRGD 1925



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 61/237 (25%), Positives = 97/237 (40%), Gaps = 45/237 (18%)

Query: 655  KHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQ 714
            K  L VS Q+ E     +    +RE  L     +  + T    ++ +L AE L L+EQ+Q
Sbjct: 835  KPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMET----LQSQLMAEKLQLQEQLQ 890

Query: 715  AEQCL--------------KENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLES 760
            AE  L              K+ LEE         +EE      L+AE ++++    +LE 
Sbjct: 891  AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE 950

Query: 761  TLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKN------------KAQRLQ 808
             L E+    + LQ  K++ E +LK     K   EQ++ E++N            +     
Sbjct: 951  QLEEEESARQKLQLEKVTTEAKLK-----KLEEEQIILEDQNCKLAKEKKLLEDRIAEFT 1005

Query: 809  TELDVSEQVQRDFVKLSQTLQVQL----ERIR----QADSLERIRAIL--NDTKLTD 855
            T L   E+  +   KL    +  +    ER+R    Q   LE+ R  L  + T L+D
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSD 1062


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  111 bits (277), Expect = 3e-24
 Identities = 181/894 (20%), Positives = 375/894 (41%), Gaps = 129/894 (14%)

Query: 20   ELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLW 79
            EL  +  E  + Q+ + QE N          + KE +L R    L   ++ L     QL 
Sbjct: 1086 ELRLLGDELKKQQEIVAQEKNHA--------IKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137

Query: 80   EAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQE 139
            E Q ++ N+           QE + E++++  E + +L+  +K      EH     +E E
Sbjct: 1138 EKQQQLLNV-----------QEEMSEMQKKINE-IENLKNELKNKELTLEH-----METE 1180

Query: 140  RTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALK 199
            R + AQ       E+  + +      E + L+   K  + + + LR  +  +E      K
Sbjct: 1181 RLELAQKLNENYEEVKSITK------ERKVLKELQKSFETERDHLRGYIREIEATGLQTK 1234

Query: 200  DKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKEL 259
            ++L  A   +KE          H    ++  R+  E    ++NTQ      D EK   +L
Sbjct: 1235 EELKIAHIHLKE----------HQETIDELRRSVSEKTAQIINTQ------DLEKSHTKL 1278

Query: 260  HEVCHLLEQERQ---QHNQLKHTWQKANDQFLESQRLLMRDMQ-----RMEIVLTSEQLR 311
             E   +L +E++      ++  T +  N+  L +++   +D        ME +  +E+ +
Sbjct: 1279 QEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQ 1338

Query: 312  QV-EELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDS 370
            +  EE+K   +E D  + + +  + K   ++E I+  +      +    Q  N +E  + 
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398

Query: 371  TRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKS 430
            T   V  ++          F   D+ + +  +      + LG S  LQ         AK 
Sbjct: 1399 TTKIVSEMEQ---------FKPKDSALLRIEI------EMLGLSKRLQESHDEMKSVAKE 1443

Query: 431  AGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLT----KDQERAIKAMTPEQEET 486
              +L          +D + EN        L+      +     K+QE  I  +     E 
Sbjct: 1444 KDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEK 1503

Query: 487  ASLLSSVTQGMESA---YVSPSGYRLVSETEWNLLQ-KEVHNAGNKLGRRCDMCSNYEKQ 542
             + +S++ + +E+      +        E ++N+ Q  EV    N+L +  +     +  
Sbjct: 1504 ETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSA 1563

Query: 543  LQGIQ---------IQEAET--------RDQVKKLQLMLRQANDQLEKT-------MKDK 578
            LQ I+         +QE++         ++++K++Q  L+   DQL++        MK+ 
Sbjct: 1564 LQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKES 1623

Query: 579  QELE-DFIKQSSEDSSHQ----ISALVLRAQASEILLEELQQG---LSQAKRDVQEQMAV 630
            QE E  F+K ++ + + +    I  L  + +  ++ LE ++     L+Q   +  E+M  
Sbjct: 1624 QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRS 1683

Query: 631  LMQSREQVS--EELVRLQKDNDSLQGKHSLHVSLQQAEDFIL--------PDTTEALREL 680
            + + R+ +   EE +++++D      + ++   L++ E+  +         +T + LR +
Sbjct: 1684 VTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGI 1743

Query: 681  VLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS 740
            V +   +I N++   +H  + LKA+ L ++E+++      +  +ET+        E+   
Sbjct: 1744 VSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDK 1803

Query: 741  ISSLKAELERIKVEKGQLESTLREKSQQLESLQ------EIKISLEEQLKKETAAKA-TV 793
            +S+++ +LE    +  +    L+    QL +L+      + K+S  EQLKK+   ++ T+
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTL 1863

Query: 794  EQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQ-VQLERIRQADSLERIRA 846
             +L  E  N AQ+L   L+  + V ++   L +  + ++LER +  +SL+  +A
Sbjct: 1864 SKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKA 1917



 Score =  107 bits (267), Expect = 5e-23
 Identities = 183/881 (20%), Positives = 378/881 (42%), Gaps = 123/881 (13%)

Query: 14   LQQRVAELEKINAE---FLRAQQQLEQEFNQKRAKFKE---LYLAKEEDLKRQNAVLQAA 67
            LQQ + E++ +  E     + Q+ L+ E +Q ++   +   + +  +E L+     L+  
Sbjct: 917  LQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQH 976

Query: 68   QDDLGHLRTQLWEAQAE---MENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKET 124
            Q+ +  L++++ E  +    ME            K   ID+ +    +   +L A +K+ 
Sbjct: 977  QETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN 1036

Query: 125  VRDYEHQFHLRLEQERTQWAQYRES--AEREI--ADLRRRLS---EGQEEENL-ENEMKK 176
                + +    L QE+ +  Q  ES  AE+E    DL+  +    E QEE  L  +E+KK
Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096

Query: 177  AQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEM 236
             QE   + ++  +  E E++   D+L E E+K+KE    K ++L              E 
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE----KSQQLQ-------------EK 1139

Query: 237  YVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMR 296
               +LN     +QE+  +++K+++E+ +L  + + +   L+H         +E++RL + 
Sbjct: 1140 QQQLLN-----VQEEMSEMQKKINEIENLKNELKNKELTLEH---------METERLELA 1185

Query: 297  DMQRMEIVLTSEQLRQVEELKKKDQEDDE-QQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                      +E   +V+ + K+ +   E Q+     +DH +  + E   I      T+E
Sbjct: 1186 QK-------LNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE---IEATGLQTKE 1235

Query: 356  E---SSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
            E   +   L   +E +D  R SV    A ++         +  D+ K   +  +    L 
Sbjct: 1236 ELKIAHIHLKEHQETIDELRRSVSEKTAQII---------NTQDLEKSHTKLQEEIPVLH 1286

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQ 472
                L       +   ++   L+      L+   S ++  D+ +L  ++M    +  K Q
Sbjct: 1287 EEQELLPNVKEVSETQETMNELE------LLTEQSTTK--DSTTLARIEMERLRLNEKFQ 1338

Query: 473  E--RAIKAMTPEQEETASLLSS--VTQGMESAYVSPSGYRL---VSETEWNLLQKEVHNA 525
            E    IK++T E++   ++  +  V       ++  +  ++    S+ E +L  KE  N 
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDK---QELE 582
              K+    +     +  L  I+I       ++  L   L++++D+++   K+K   Q L+
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEI-------EMLGLSKRLQESHDEMKSVAKEKDDLQRLQ 1451

Query: 583  DFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL 642
            + ++  S+     I  +V +   +E  L+     L + +  + E    L +   ++S   
Sbjct: 1452 EVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQ 1511

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL--VLKYREDIINVRTAADHVEE 700
             +L+  ND LQ K  +    ++ E F +   +E   ++  + +++E     R A D   +
Sbjct: 1512 KQLEAINDKLQNK--IQEIYEKEEQFNIKQISEVQEKVNELKQFKEH----RKAKDSALQ 1565

Query: 701  KLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLES 760
             +++++L L  ++Q  Q       E +Q+ I+  KEE      +K   E +++E+ QL+ 
Sbjct: 1566 SIESKMLELTNRLQESQ-------EEIQIMIKE-KEE------MKRVQEALQIERDQLKE 1611

Query: 761  TLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRD 820
              +E   +++  QE     E Q  K TA   T E+ M E ++  ++ +T+    E ++ +
Sbjct: 1612 NTKEIVAKMKESQE----KEYQFLKMTAVNETQEK-MCEIEHLKEQFETQKLNLENIETE 1666

Query: 821  FVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPE 861
             ++L+Q L   LE +R           + +T   + +QL E
Sbjct: 1667 NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 187/879 (21%), Positives = 368/879 (41%), Gaps = 137/879 (15%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKE-EDLKRQNAVLQAAQD 69
            +V   Q    + +  A+   +Q + EQ  N K    +   +  E E  K +++ L   + 
Sbjct: 1362 EVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEI 1421

Query: 70   DLGHLRTQLWEAQAEMENIKAIATVSENTK--QEAIDEVKRQWREEVASLQAVMKETVRD 127
            ++  L  +L E+  EM   K++A   ++ +  QE +     Q +E +  + A   ET  +
Sbjct: 1422 EMLGLSKRLQESHDEM---KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478

Query: 128  YEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSV 187
             +       EQE T            I +LR  LSE  +E  +    K+ +   +KL++ 
Sbjct: 1479 LKVAHCCLKEQEET------------INELRVNLSE--KETEISTIQKQLEAINDKLQNK 1524

Query: 188  VMPM-EKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
            +  + EKE      +++E ++K+ EL     K+   + +A+ S    +E  +  L  +  
Sbjct: 1525 IQEIYEKEEQFNIKQISEVQEKVNEL-----KQFKEHRKAKDSALQSIESKMLELTNRLQ 1579

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLT 306
              QE+ + + KE  E+  + E  + + +QLK   ++   +  ESQ    + ++   +  T
Sbjct: 1580 ESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET 1639

Query: 307  SEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
             E++ ++E LK    E  E Q+LN           E I++  +     EE  + ++ E +
Sbjct: 1640 QEKMCEIEHLK----EQFETQKLNLENIE-----TENIRLTQILHENLEEMRS-VTKERD 1689

Query: 367  HLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNY 426
             L S   ++                K + D  K+ LR   + D        + K +  + 
Sbjct: 1690 DLRSVEETL----------------KVERDQLKENLRETITRD---LEKQEELKIVHMHL 1730

Query: 427  KAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD----QERAIKAM-TP 481
            K        +     L G  S   N  +     L+  +  +  +D    +E  I  M   
Sbjct: 1731 KE------HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLK 1784

Query: 482  EQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEK 541
            EQ+ET   L  +        VS    +L +      +QK++ N+  KL  +       E 
Sbjct: 1785 EQQETIDKLRGI--------VSEKTDKLSN------MQKDLENSNAKLQEKIQELKANEH 1830

Query: 542  QLQGIQIQEAETRDQVKKLQLMLRQANDQ--------------LEKTMKDKQELEDFIKQ 587
            QL  ++    ET+ +V +++ + +Q  DQ               +K  ++ +E++  +K+
Sbjct: 1831 QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE 1890

Query: 588  SSEDSSHQISALVLRAQASEILLE------ELQQGLSQAKRDVQEQMAVLMQSREQVSEE 641
                   + +  + R Q  E L E      E+QQ L  A+   +E    + + RE++SE+
Sbjct: 1891 RDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEK 1950

Query: 642  LVR---LQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL-VLKYREDIINVRTAADH 697
             ++   +QKD D  + K  L   +Q+ +           +EL +L+ +ED+        +
Sbjct: 1951 TIQISDIQKDLD--KSKDELQKKIQELQK----------KELQLLRVKEDV--------N 1990

Query: 698  VEEKLKAEILFLKEQIQAEQCLKENLE-ETLQL--EIENCKEEIASISSLKAELERIKVE 754
            +  K   E+  LK+Q +A+    +++  +  QL  ++    EEI  ++  + EL RIK  
Sbjct: 1991 MSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIK-- 2048

Query: 755  KGQLESTLREKSQQLESLQEI--KISLEEQLKKETAAKATVEQLMFEE-KNKAQRLQTEL 811
                ES   E+ Q + +L+E+  +     Q+K E    +  +Q + E  + K  R++  L
Sbjct: 2049 ----ESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELL 2104

Query: 812  DVSEQVQRDFVKLSQ-TLQVQLERIRQADSLERIRAILN 849
                ++   +  L++ +L ++ E   Q +   R++A L+
Sbjct: 2105 KRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLS 2143



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 175/869 (20%), Positives = 365/869 (42%), Gaps = 176/869 (20%)

Query: 18   VAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQ 77
            ++E+E   A  L  Q+ +E E N  RA +  L L  E+                  LRT+
Sbjct: 479  LSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQ------------------LRTE 520

Query: 78   LWEAQAEME---NIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETV---RDYEHQ 131
              E + +++   ++     +   TK++     + Q   E+++L+ ++K      +D E++
Sbjct: 521  KEEMELKLKEKNDLDEFEALERKTKKDQ----EMQLIHEISNLKNLVKHAEVYNQDLENE 576

Query: 132  FHLRLEQERTQWAQYRESAE----REIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSV 187
               ++E  R +  Q ++  E    +++ +++  LS   E      +MK+   DAE   +V
Sbjct: 577  LSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAE---TV 633

Query: 188  VMPMEKEIAALKDKLTEAEDKIKELEASKVKELNH-------YLEAEKSCRTDLEMYV-A 239
             +  ++E A L+ +  E ++K+KEL A+  K++ +        LEA+K  + DLE  + +
Sbjct: 634  ALDAKRESAFLRSENLELKEKMKEL-ATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQS 692

Query: 240  VLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQ 299
              N    +      K+ K+L  +C+L     +   ++    ++ N +  E++ L      
Sbjct: 693  AFNEITKLTSLIDGKVPKDL--LCNL-----ELEGKITDLQKELNKEVEENEAL------ 739

Query: 300  RMEIVLTSEQLR---QVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEE 356
            R E++L SE      +VE L+K+ Q+  E+  +                           
Sbjct: 740  REEVILLSELKSLPSEVERLRKEIQDKSEELHI--------------------------- 772

Query: 357  SSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGS 416
                +++E++ L S      S   GLL   G           KD L   QS         
Sbjct: 773  ----ITSEKDKLFSEVVHKESRVQGLLEEIGKT---------KDDLATTQSNYKSTDQEF 819

Query: 417  LQSKALGYNYKAKSAGNLDESDF--GPLVGADSVSENFDTASLGSLQMPSGFMLTKDQER 474
               K L  +++ K    L+E++     +V     ++ FD+ SLG+L+    +   + QE+
Sbjct: 820  QNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS-SLGALKTELSYKTQELQEK 878

Query: 475  AIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCD 534
                 T E +E  + +  + + +E+            ++    +++E      KL     
Sbjct: 879  -----TREVQERLNEMEQLKEQLENR-----------DSTLQTVEREKTLITEKL----- 917

Query: 535  MCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSH 594
                 ++ L+ ++    E +D +K+LQ  L+   DQL      K ++ D +  + +    
Sbjct: 918  -----QQTLEEVKTLTQE-KDDLKQLQESLQIERDQL------KSDIHDTVNMNIDTQEQ 965

Query: 595  QISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQG 654
              +AL          L++ Q+ ++  K  + E+++  +   E   E     Q+    +  
Sbjct: 966  LRNALES--------LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDK 1017

Query: 655  KHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQ 714
            K  L     Q        T +     +++ +  I ++    + +++ L++ ++  KEQ++
Sbjct: 1018 KQDLEAKNTQTL------TADVKDNEIIEQQRKIFSLIQEKNELQQMLES-VIAEKEQLK 1070

Query: 715  AEQCLKENLEETL--QLEIENCKEEIASISSLKAELERIKVEK-----------GQLEST 761
             +  LKEN+E T+  Q E+    +E+     + A+ +   ++K            ++E  
Sbjct: 1071 TD--LKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEK 1128

Query: 762  LREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDF 821
            L+EKSQQL+  Q+  ++++E++ +       +E L  E KNK   L       E ++ + 
Sbjct: 1129 LKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTL-------EHMETER 1181

Query: 822  VKLSQTLQVQLERIRQADSLERIRAILND 850
            ++L+Q L    E ++   S+ + R +L +
Sbjct: 1182 LELAQKLNENYEEVK---SITKERKVLKE 1207



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 166/857 (19%), Positives = 358/857 (41%), Gaps = 132/857 (15%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQ 68
            + + ++ +    L +   E    Q+QLE   ++ + K +E+Y  +E+   +Q + +Q   
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547

Query: 69   DDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDY 128
            ++L   +       + +++I++      N  QE+ +E+           Q ++KE     
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI-----------QIMIKEKEEMK 1596

Query: 129  EHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVV 188
              Q  L++E++     Q +E+ +  +A    ++ E QE+E    +M    E  EK+    
Sbjct: 1597 RVQEALQIERD-----QLKENTKEIVA----KMKESQEKEYQFLKMTAVNETQEKM---- 1643

Query: 189  MPMEKEIAALKDKLTEAEDKIKELEASKVK---ELNHYLEAEKSCRTDLEMYVAVLNTQK 245
                 EI  LK++    +  ++ +E   ++    L+  LE  +S   + +     L + +
Sbjct: 1644 ----CEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERD----DLRSVE 1695

Query: 246  SVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQR-----------LL 294
              L+ + ++L++ L E     + E+Q+  ++ H   K + + ++  R            +
Sbjct: 1696 ETLKVERDQLKENLRETI-TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNM 1754

Query: 295  MRDMQRMEIVLTSEQLRQVEELK------KKDQED-DEQQRLNKRKDHKKADVEEEIKIP 347
             +D++     L ++ L+  EEL+      K+ QE  D+ + +   K  K +++++++   
Sbjct: 1755 QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL--- 1811

Query: 348  VVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQS 407
                   E S+A+L   +E +   + + H L    L    +   K  ++M  + L++   
Sbjct: 1812 -------ENSNAKL---QEKIQELKANEHQLIT--LKKDVNETQKKVSEM--EQLKKQIK 1857

Query: 408  TDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFM 467
              SL T   L+ + L  N   K   NL+E     +   D++    +T  L   Q+     
Sbjct: 1858 DQSL-TLSKLEIENL--NLAQKLHENLEEMK-SVMKERDNLRRVEETLKLERDQLKESLQ 1913

Query: 468  LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
             TK ++  I+    ++ +TA +LS                           ++ V     
Sbjct: 1914 ETKARDLEIQ----QELKTARMLSKEH------------------------KETVDKLRE 1945

Query: 528  KLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQ 587
            K+  +    S+ +K L   + +  +   +++K +L L +  + +  + K   E+E   KQ
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQ 2005

Query: 588  SSEDSSHQISALVLRAQASEILLEELQQGLSQAK-----RDVQEQMAVLMQSREQVSEEL 642
                +    S  +   Q ++ L E L++    AK     R ++E + +          E+
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +   + N  ++ +  L    QQ         TE+LRE   + +E +       DH  E L
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQ-------HLTESLREKCSRIKELLKRYSEMDDHY-ECL 2117

Query: 703  KAEILFLKEQIQAEQCLKENLEETLQ---LEIENCKEEIASISSLKAELERI-KVEKGQL 758
                L L+++I+ ++ L   ++  L    L+ ++ ++   +      E  RI K  K  L
Sbjct: 2118 NRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVL 2177

Query: 759  ESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQ 818
                + K +Q ES+ + ++   ++++K+       ++L+     K Q LQ + DV  +  
Sbjct: 2178 SYVTKIKEEQHESINKFEMDFIDEVEKQ-------KELLI----KIQHLQQDCDVPSREL 2226

Query: 819  RDFVKLSQTLQVQLERI 835
            RD +KL+Q + + +E I
Sbjct: 2227 RD-LKLNQNMDLHIEEI 2242



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 140/819 (17%), Positives = 326/819 (39%), Gaps = 105/819 (12%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            SLQ+  A   +I  E L+  + L +E  +   K +E    K   +      L  ++D+L 
Sbjct: 1911 SLQETKARDLEIQQE-LKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQ 1969

Query: 73   HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQF 132
                +L + + ++  +K    +S     E ++++K+Q+  +  S+Q+V  +  +    + 
Sbjct: 1970 KKIQELQKKELQLLRVKEDVNMSHKKINE-MEQLKKQFEAQNLSMQSVRMDNFQ-LTKKL 2027

Query: 133  HLRLEQ------ERTQWAQYRESAERE----IADLRRRLSEGQEEENLENEMKKAQEDAE 182
            H  LE+      ER +  + +ES + E    IA LR  ++  ++   ++ E +   +  +
Sbjct: 2028 HESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQ 2087

Query: 183  KLRSVVMPMEKEIAALKDKLTEAEDK---IKELEASKVKELNHYLEAEKSCRTDLEM-YV 238
             L   +      I  L  + +E +D    +  L     KE+    E     + +L + Y+
Sbjct: 2088 HLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYL 2147

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
               + +K  L    ++   E H +   L+       ++K    ++ ++F      +    
Sbjct: 2148 QTKHIEK--LFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF--EMDFIDEVE 2203

Query: 299  QRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESS 358
            ++ E+++  + L+Q  ++  ++  D    +LN+  D     +EE +K       ++ E  
Sbjct: 2204 KQKELLIKIQHLQQDCDVPSRELRD---LKLNQNMD---LHIEEILK-----DFSESEFP 2252

Query: 359  AQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQ 418
            +  +  ++ L + +     L+  L        ++ D +  K+G+++              
Sbjct: 2253 SIKTEFQQVLSNRKEMTQFLEEWLN-------TRFDIEKLKNGIQKE------------- 2292

Query: 419  SKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKA 478
                  N +     N   +    ++   + S  F+  S           ++K+ E+ +K+
Sbjct: 2293 ------NDRICQVNNFFNNR---IIAIMNESTEFEERSA---------TISKEWEQDLKS 2334

Query: 479  MTPEQEETASLLSSVTQGMES-AYVSPSGYRL----VSETEWNLLQKEVHNAGNKLGRRC 533
            +  + E+      ++   + S A V+P+        V+     L  +++    N L    
Sbjct: 2335 LKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAK 2394

Query: 534  DMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSS 593
            +   + E ++  +Q +   T D + KLQ  + ++N  LEKT +  Q L+D +   ++   
Sbjct: 2395 ESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYK 2454

Query: 594  HQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQ 653
             +I  L ++    ++   E  +   + ++++    A +     +  +E++RL ++N    
Sbjct: 2455 EEIEDLKMKLVKIDL---EKMKNAKEFEKEISATKATV-----EYQKEVIRLLREN---- 2502

Query: 654  GKHSLHVSLQQAEDFILPDTTE---ALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
                L  S Q  +  ++ + T+   + + L       I+    A     E ++ E    K
Sbjct: 2503 ----LRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISK 2558

Query: 711  EQIQAEQCLKENLE-----ETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREK 765
             + Q EQ +K+  E     + L  E++  KE      + K        +  ++  T  +K
Sbjct: 2559 LKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKK 2618

Query: 766  SQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKA 804
             Q   S        +E+  ++   K + +   F+ ++K+
Sbjct: 2619 KQITPS------QCKERNLQDPVPKESPKSCFFDSRSKS 2651



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 80/417 (19%), Positives = 172/417 (41%), Gaps = 77/417 (18%)

Query: 11   DVSLQQRV-AELEKINAEFLRAQ-QQLEQEFNQKRAKFKELYLAKEE------DLKRQNA 62
            D+ L Q +   +E+I  +F  ++   ++ EF Q  +  KE+    EE      D+++   
Sbjct: 2228 DLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKN 2287

Query: 63   VLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTK-QEAIDEVKRQWREEVASLQAVM 121
             +Q   D +  +            N + IA ++E+T+ +E    + ++W +++ SL+   
Sbjct: 2288 GIQKENDRICQVNNFF--------NNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKN 2339

Query: 122  KETVRDYEHQFHLRLEQERTQWAQYRESAE-REIADLRRRLSEGQEEE--NLENEMKKAQ 178
            ++  ++Y+      L+      AQ   + +  +   +  R ++   E+   LEN + +A+
Sbjct: 2340 EKLFKNYQ-----TLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAK 2394

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE--ASKVKELNHYLEAE--------K 228
            E A    S ++ M+KE+    D + + + K+ E      K KE    L+ +        K
Sbjct: 2395 ESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYK 2454

Query: 229  SCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTW---QKAND 285
                DL+M +  ++ +K    ++A++  KE+      +E +++    L+      Q+A D
Sbjct: 2455 EEIEDLKMKLVKIDLEK---MKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQD 2511

Query: 286  QFLESQRLLMRDMQR--------------MEIVLTSEQLRQVEELKKKDQEDDE------ 325
              + S+    +   +                ++L SE +R  +E+ K  Q++++      
Sbjct: 2512 TSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKN 2571

Query: 326  ----------------QQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
                            ++R  KR+ HK+   E   K P V     ++     S  +E
Sbjct: 2572 ELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKE 2628


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  110 bits (275), Expect = 6e-24
 Identities = 175/884 (19%), Positives = 376/884 (42%), Gaps = 95/884 (10%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEG-----QEEENLENEMKKAQEDAEKLRS 186
              +RL+ E T+  + R  AE E+  LR R  E      Q +E  E   ++ Q+++++ R 
Sbjct: 1455 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512

Query: 187  VVMPMEKEIAA-----------------LKDKLTEAEDKIKELEASKVKELNHYLE-AEK 228
              + +   + A                 L+ +  EAE ++++ E  + +++   LE A++
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 229  SCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFL 288
            S   +L+   A    + + L+     L++E   V  L E+  ++  Q     +   +   
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 289  ESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPV 348
            E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE+     
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEEQ----- 1682

Query: 349  VCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKDGLRRAQ 406
              A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++ L R Q
Sbjct: 1683 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740

Query: 407  STDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSG- 465
               +  T    + +A     +A+      E        A+  S +    S   L+  +G 
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795

Query: 466  FMLTKDQERAIKAMTPEQ-------EETASLLSSVTQGMESAYVSPSGY--RLVSETEWN 516
            F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL +E E  
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 517  LLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ------ 570
            L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D       
Sbjct: 1856 LKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910

Query: 571  --LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQA 620
              +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q  L  A
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 621  KRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL 680
            +   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     EA R  
Sbjct: 1971 R---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025

Query: 681  VLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS 740
                +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ E     +    
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082

Query: 741  ISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE- 799
              + +   E  +  + Q E    +  +Q+E  + +K S EEQ +    A+A  E+L  E 
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
            E+  A+R Q E     Q Q    ++ +  +   + +RQ   +E+
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186



 Score =  108 bits (270), Expect = 2e-23
 Identities = 178/883 (20%), Positives = 366/883 (41%), Gaps = 114/883 (12%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1850

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1905

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1906 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1956

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2017 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2069

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2070 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2182

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2183 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2227

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2228 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMA-------------VLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL 748
               R  A+ + EKL    L  +E++         L +TL+++ +    +   +    AEL
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKV--------TLVQTLEIQRQQSDHDAERLREAIAEL 2455

Query: 749  ERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKN----KA 804
            ER K +  Q    L+ KS++++++Q      +EQL +ET A   ++Q    EK+    + 
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQA---LQQSFLSEKDSLLQRE 2506

Query: 805  QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAI 847
            + ++ E    EQ+ +D V  +Q L+ + +R +Q    ER R +
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549



 Score =  106 bits (264), Expect = 1e-22
 Identities = 181/869 (20%), Positives = 364/869 (41%), Gaps = 77/869 (8%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1671

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1788

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1846

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1900

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1959

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2020 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2139 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2190

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2191 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2243

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL---ERIKV 753
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+  + +      E +  
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303

Query: 754  EKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDV 813
            ++   E  L+EK Q ++    +K   E   +++  A+    +L  +++  AQ+L      
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL------ 2357

Query: 814  SEQVQRDFVKLSQTLQVQLERIRQADSLE 842
            +E+ Q     L    Q QLE   +A+ L+
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLK 2386



 Score =  101 bits (252), Expect = 3e-21
 Identities = 176/861 (20%), Positives = 352/861 (40%), Gaps = 128/861 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1884 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2003

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 2004 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2063

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2124 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2230

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D                        
Sbjct: 2231 ----FSVRVQMEE--LSKLKARIEAENRALILRDKD-----------------------N 2261

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS-GFMLTKD 471
            T   LQ +A      A+ A  L        V A   +     A     Q  +    + K+
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGR 531
            + +A++  T  + E   L        E A                 LQ++      +L  
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQKELAQEQA---------------RRLQEDKEQMAQQLAE 2359

Query: 532  RCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSED 591
                   +++ L+  + ++ E   + ++L+L + + +    +  +D Q      ++ +E+
Sbjct: 2360 ETQ---GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF----RKQAEE 2412

Query: 592  SSHQISALVLRAQASEILLEELQQGLSQAKRDVQ---EQMAVLMQSREQVSEELVRLQKD 648
               ++    L  Q    L++ L+    Q+  D +   E +A L + +E++ +E   LQ  
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472

Query: 649  NDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILF 708
            ++ +Q       ++QQ +   L   T+AL++  L  ++ ++      +  +EK K E LF
Sbjct: 2473 SEEMQ-------TVQQEQ---LLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLF 2520

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQ 768
              E  +A+Q  +E   +  Q+E E  +        L A +E  +  + + E  +R K ++
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQR--------LVASMEEARRRQHEAEEGVRRKQEE 2572

Query: 769  LESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 828
            L+ L       E+Q +++       E+L+ EE    QRL+ +L + E+  R    L+ + 
Sbjct: 2573 LQQL-------EQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHR--AALAHSE 2613

Query: 829  QVQLERIRQADSLERIRAILN 849
            +V   ++    +L   R  L+
Sbjct: 2614 EVTASQVAATKTLPNGRDALD 2634



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 170/827 (20%), Positives = 317/827 (38%), Gaps = 134/827 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 2010

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2179

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2180 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2225

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2286 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2322

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2323 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2364

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2413

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2470

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2531 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2583

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQL 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     + 
Sbjct: 2584 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2640

Query: 759  E-----STLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEE 800
            E       LR K    + LQE  I   E+L++      TV++L   E
Sbjct: 2641 EPEHSFDGLRRK-VSAQRLQEAGILSAEELQRLAQGHTTVDELARRE 2686



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 174/828 (21%), Positives = 336/828 (40%), Gaps = 96/828 (11%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1083

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143

Query: 193  KEIAALKDKLTEAE---DKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A+   +++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1199

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++       L   R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1200 RELEQLGRQ-------LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1253 -ALLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1307

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1363

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETAS 488
            +    L++     L  A + ++         LQ      + + +E A+ A   ++     
Sbjct: 1364 EVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1420

Query: 489  LLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI 548
             L  + Q  E+   + +     +E     +++E+     +L          E +LQ ++ 
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480

Query: 549  Q----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL----V 600
            +    EA+ R   ++ + + RQ  D+ ++  + + EL   +K  +E +  +  AL     
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 601  LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHS-LH 659
            LR QA     EE ++ L QA+ +   Q+ V +++ ++ +E    LQ    S   K + L 
Sbjct: 1541 LRLQA-----EEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASFAEKTAQLE 1593

Query: 660  VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEIL----FLKEQIQA 715
             SLQ+    +       LRE   +  +       A +  E +L+   L     L+ ++QA
Sbjct: 1594 RSLQEEHVAV-----AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQL-ESLQE 774
            E+  ++  +   Q E E  KEE    +  + + E   V + +L     EK +QL E   +
Sbjct: 1649 EEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706

Query: 775  IKISLEEQ---LKKETAAKATVEQLMFEEKNKAQR------------------LQTELDV 813
             +++ E++   L+ ET       QL+ EE  + QR                  ++ E++V
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766

Query: 814  --------SEQVQRDFVKLSQTLQVQLERIRQ-ADSLERIRAILNDTK 852
                     E+ +    K  Q L+ +  R R+ A+   R+RA+  + K
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 86/463 (18%), Positives = 186/463 (40%), Gaps = 97/463 (20%)

Query: 450  ENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL 509
            E  +T ++  L++P    L K+  R       EQ++  + +  + +G+          RL
Sbjct: 997  EACETRTVHRLRLP----LDKEPARECAQRIAEQQKAQAEVEGLGKGVA---------RL 1043

Query: 510  VSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQAND 569
             +E E  L   E   A   L    ++     +Q++ +    A   +++K + L++R    
Sbjct: 1044 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS---AIYLEKLKTISLVIRGTQG 1100

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
              E     +++L++         +  + A +   +A++  L++L+   ++A++   + + 
Sbjct: 1101 AEEVLRAHEEQLKE---------AQAVPATLPELEATKASLKKLR-AQAEAQQPTFDALR 1150

Query: 630  VLMQSREQVSEELVRLQKDND-SLQGKHSLHVSLQQAEDFILPDTTEALREL------VL 682
              ++  ++V E L +   + D  ++        L +    +L  T    REL      + 
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210

Query: 683  KYRED-------IINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENC- 734
             YRE        + + R   + ++    A+   ++EQ++ EQ L E +E   + ++E C 
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQ 1269

Query: 735  ----------KEEIASISSLKAELERI-------KVEKGQ-------------------- 757
                      K+    + + KA+LE +       KV+ G                     
Sbjct: 1270 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1329

Query: 758  -------LESTLR-----------EKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
                   +  TLR           +++++ E L E++ +LE+Q +   A      Q   E
Sbjct: 1330 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1389

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 842
             K   QR+Q E+   E+   D  +  +++Q +L+++RQ+   E
Sbjct: 1390 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1432


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  110 bits (275), Expect = 6e-24
 Identities = 175/884 (19%), Positives = 376/884 (42%), Gaps = 95/884 (10%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1339 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1398

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1399 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEG-----QEEENLENEMKKAQEDAEKLRS 186
              +RL+ E T+  + R  AE E+  LR R  E      Q +E  E   ++ Q+++++ R 
Sbjct: 1459 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1516

Query: 187  VVMPMEKEIAA-----------------LKDKLTEAEDKIKELEASKVKELNHYLE-AEK 228
              + +   + A                 L+ +  EAE ++++ E  + +++   LE A++
Sbjct: 1517 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1576

Query: 229  SCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFL 288
            S   +L+   A    + + L+     L++E   V  L E+  ++  Q     +   +   
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633

Query: 289  ESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPV 348
            E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE+     
Sbjct: 1634 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEEQ----- 1686

Query: 349  VCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKDGLRRAQ 406
              A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++ L R Q
Sbjct: 1687 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1744

Query: 407  STDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSG- 465
               +  T    + +A     +A+      E        A+  S +    S   L+  +G 
Sbjct: 1745 REAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRLEAEAGR 1799

Query: 466  FMLTKDQERAIKAMTPEQ-------EETASLLSSVTQGMESAYVSPSGY--RLVSETEWN 516
            F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL +E E  
Sbjct: 1800 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859

Query: 517  LLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ------ 570
            L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D       
Sbjct: 1860 LKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1914

Query: 571  --LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQA 620
              +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q  L  A
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974

Query: 621  KRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL 680
            +   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     EA R  
Sbjct: 1975 R---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2029

Query: 681  VLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS 740
                +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ E     +    
Sbjct: 2030 ERAEQESARQLQLAQEAAQKRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2086

Query: 741  ISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE- 799
              + +   E  +  + Q E    +  +Q+E  + +K S EEQ +    A+A  E+L  E 
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2146

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
            E+  A+R Q E     Q Q    ++ +  +   + +RQ   +E+
Sbjct: 2147 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2190



 Score =  108 bits (270), Expect = 2e-23
 Identities = 178/883 (20%), Positives = 366/883 (41%), Gaps = 114/883 (12%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1854

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1855 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1909

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1910 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1960

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2020

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2021 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2073

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2074 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2131

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2132 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2186

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2187 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2231

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2232 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2287

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMA-------------VLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2288 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2347

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2407

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL 748
               R  A+ + EKL    L  +E++         L +TL+++ +    +   +    AEL
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKV--------TLVQTLEIQRQQSDHDAERLREAIAEL 2459

Query: 749  ERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKN----KA 804
            ER K +  Q    L+ KS++++++Q      +EQL +ET A   ++Q    EK+    + 
Sbjct: 2460 EREKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQA---LQQSFLSEKDSLLQRE 2510

Query: 805  QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAI 847
            + ++ E    EQ+ +D V  +Q L+ + +R +Q    ER R +
Sbjct: 2511 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553



 Score =  106 bits (264), Expect = 1e-22
 Identities = 181/869 (20%), Positives = 364/869 (41%), Gaps = 77/869 (8%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1558 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1617

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1618 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1675

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1792

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1793 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1850

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1904

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1963

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2023

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2024 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2142

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2143 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2194

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2195 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2247

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL---ERIKV 753
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+  + +      E +  
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2307

Query: 754  EKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDV 813
            ++   E  L+EK Q ++    +K   E   +++  A+    +L  +++  AQ+L      
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL------ 2361

Query: 814  SEQVQRDFVKLSQTLQVQLERIRQADSLE 842
            +E+ Q     L    Q QLE   +A+ L+
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLK 2390



 Score =  101 bits (252), Expect = 3e-21
 Identities = 176/861 (20%), Positives = 352/861 (40%), Gaps = 128/861 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1888 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1947

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1948 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2007

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 2008 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2067

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2068 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2128 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2234

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D                        
Sbjct: 2235 ----FSVRVQMEE--LSKLKARIEAENRALILRDKD-----------------------N 2265

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS-GFMLTKD 471
            T   LQ +A      A+ A  L        V A   +     A     Q  +    + K+
Sbjct: 2266 TQRFLQEEAEKMKQVAEEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKE 2318

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGR 531
            + +A++  T  + E   L        E A                 LQ++      +L  
Sbjct: 2319 KMQAVQEATRLKAEAELLQQQKELAQEQA---------------RRLQEDKEQMAQQLAE 2363

Query: 532  RCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSED 591
                   +++ L+  + ++ E   + ++L+L + + +    +  +D Q      ++ +E+
Sbjct: 2364 ETQ---GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF----RKQAEE 2416

Query: 592  SSHQISALVLRAQASEILLEELQQGLSQAKRDVQ---EQMAVLMQSREQVSEELVRLQKD 648
               ++    L  Q    L++ L+    Q+  D +   E +A L + +E++ +E   LQ  
Sbjct: 2417 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476

Query: 649  NDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILF 708
            ++ +Q       ++QQ +   L   T+AL++  L  ++ ++      +  +EK K E LF
Sbjct: 2477 SEEMQ-------TVQQEQ---LLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLF 2524

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQ 768
              E  +A+Q  +E   +  Q+E E  +        L A +E  +  + + E  +R K ++
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQR--------LVASMEEARRRQHEAEEGVRRKQEE 2576

Query: 769  LESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 828
            L+ L       E+Q +++       E+L+ EE    QRL+ +L + E+  R    L+ + 
Sbjct: 2577 LQQL-------EQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHR--AALAHSE 2617

Query: 829  QVQLERIRQADSLERIRAILN 849
            +V   ++    +L   R  L+
Sbjct: 2618 EVTASQVAATKTLPNGRDALD 2638



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 170/827 (20%), Positives = 317/827 (38%), Gaps = 134/827 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 2014

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2072

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2183

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2184 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2229

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2290 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2326

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2327 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2368

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2369 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2417

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2474

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2534

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2535 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2587

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQL 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     + 
Sbjct: 2588 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2644

Query: 759  E-----STLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEE 800
            E       LR K    + LQE  I   E+L++      TV++L   E
Sbjct: 2645 EPEHSFDGLRRK-VSAQRLQEAGILSAEELQRLAQGHTTVDELARRE 2690



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 174/828 (21%), Positives = 336/828 (40%), Gaps = 96/828 (11%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1032 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1087

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1088 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1147

Query: 193  KEIAALKDKLTEAE---DKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A+   +++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1148 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1203

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++       L   R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1204 RELEQLGRQ-------LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1256

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1257 -ALLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1311

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1312 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1367

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETAS 488
            +    L++     L  A + ++         LQ      + + +E A+ A   ++     
Sbjct: 1368 EVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1424

Query: 489  LLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI 548
             L  + Q  E+   + +     +E     +++E+     +L          E +LQ ++ 
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1484

Query: 549  Q----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL----V 600
            +    EA+ R   ++ + + RQ  D+ ++  + + EL   +K  +E +  +  AL     
Sbjct: 1485 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1544

Query: 601  LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHS-LH 659
            LR QA     EE ++ L QA+ +   Q+ V +++ ++ +E    LQ    S   K + L 
Sbjct: 1545 LRLQA-----EEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASFAEKTAQLE 1597

Query: 660  VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEIL----FLKEQIQA 715
             SLQ+    +       LRE   +  +       A +  E +L+   L     L+ ++QA
Sbjct: 1598 RSLQEEHVAV-----AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQL-ESLQE 774
            E+  ++  +   Q E E  KEE    +  + + E   V + +L     EK +QL E   +
Sbjct: 1653 EEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1710

Query: 775  IKISLEEQ---LKKETAAKATVEQLMFEEKNKAQR------------------LQTELDV 813
             +++ E++   L+ ET       QL+ EE  + QR                  ++ E++V
Sbjct: 1711 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1770

Query: 814  --------SEQVQRDFVKLSQTLQVQLERIRQ-ADSLERIRAILNDTK 852
                     E+ +    K  Q L+ +  R R+ A+   R+RA+  + K
Sbjct: 1771 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 86/463 (18%), Positives = 186/463 (40%), Gaps = 97/463 (20%)

Query: 450  ENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL 509
            E  +T ++  L++P    L K+  R       EQ++  + +  + +G+          RL
Sbjct: 1001 EACETRTVHRLRLP----LDKEPARECAQRIAEQQKAQAEVEGLGKGVA---------RL 1047

Query: 510  VSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQAND 569
             +E E  L   E   A   L    ++     +Q++ +    A   +++K + L++R    
Sbjct: 1048 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS---AIYLEKLKTISLVIRGTQG 1104

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
              E     +++L++         +  + A +   +A++  L++L+   ++A++   + + 
Sbjct: 1105 AEEVLRAHEEQLKE---------AQAVPATLPELEATKASLKKLR-AQAEAQQPTFDALR 1154

Query: 630  VLMQSREQVSEELVRLQKDND-SLQGKHSLHVSLQQAEDFILPDTTEALREL------VL 682
              ++  ++V E L +   + D  ++        L +    +L  T    REL      + 
Sbjct: 1155 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1214

Query: 683  KYRED-------IINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENC- 734
             YRE        + + R   + ++    A+   ++EQ++ EQ L E +E   + ++E C 
Sbjct: 1215 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQ 1273

Query: 735  ----------KEEIASISSLKAELERI-------KVEKGQ-------------------- 757
                      K+    + + KA+LE +       KV+ G                     
Sbjct: 1274 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1333

Query: 758  -------LESTLR-----------EKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
                   +  TLR           +++++ E L E++ +LE+Q +   A      Q   E
Sbjct: 1334 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1393

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 842
             K   QR+Q E+   E+   D  +  +++Q +L+++RQ+   E
Sbjct: 1394 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1436


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  110 bits (275), Expect = 6e-24
 Identities = 175/884 (19%), Positives = 376/884 (42%), Gaps = 95/884 (10%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEG-----QEEENLENEMKKAQEDAEKLRS 186
              +RL+ E T+  + R  AE E+  LR R  E      Q +E  E   ++ Q+++++ R 
Sbjct: 1455 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512

Query: 187  VVMPMEKEIAA-----------------LKDKLTEAEDKIKELEASKVKELNHYLE-AEK 228
              + +   + A                 L+ +  EAE ++++ E  + +++   LE A++
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 229  SCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFL 288
            S   +L+   A    + + L+     L++E   V  L E+  ++  Q     +   +   
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 289  ESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPV 348
            E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE+     
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEEQ----- 1682

Query: 349  VCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKDGLRRAQ 406
              A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++ L R Q
Sbjct: 1683 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740

Query: 407  STDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSG- 465
               +  T    + +A     +A+      E        A+  S +    S   L+  +G 
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795

Query: 466  FMLTKDQERAIKAMTPEQ-------EETASLLSSVTQGMESAYVSPSGY--RLVSETEWN 516
            F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL +E E  
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 517  LLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ------ 570
            L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D       
Sbjct: 1856 LKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910

Query: 571  --LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQA 620
              +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q  L  A
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 621  KRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL 680
            +   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     EA R  
Sbjct: 1971 R---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025

Query: 681  VLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS 740
                +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ E     +    
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082

Query: 741  ISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE- 799
              + +   E  +  + Q E    +  +Q+E  + +K S EEQ +    A+A  E+L  E 
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
            E+  A+R Q E     Q Q    ++ +  +   + +RQ   +E+
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186



 Score =  108 bits (270), Expect = 2e-23
 Identities = 178/883 (20%), Positives = 366/883 (41%), Gaps = 114/883 (12%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1850

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1905

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1906 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1956

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2017 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2069

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2070 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2182

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2183 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2227

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2228 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMA-------------VLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL 748
               R  A+ + EKL    L  +E++         L +TL+++ +    +   +    AEL
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKV--------TLVQTLEIQRQQSDHDAERLREAIAEL 2455

Query: 749  ERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKN----KA 804
            ER K +  Q    L+ KS++++++Q      +EQL +ET A   ++Q    EK+    + 
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQA---LQQSFLSEKDSLLQRE 2506

Query: 805  QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAI 847
            + ++ E    EQ+ +D V  +Q L+ + +R +Q    ER R +
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549



 Score =  106 bits (264), Expect = 1e-22
 Identities = 181/869 (20%), Positives = 364/869 (41%), Gaps = 77/869 (8%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1671

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1788

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1846

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1900

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1959

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2020 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2139 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2190

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2191 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2243

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL---ERIKV 753
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+  + +      E +  
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303

Query: 754  EKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDV 813
            ++   E  L+EK Q ++    +K   E   +++  A+    +L  +++  AQ+L      
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL------ 2357

Query: 814  SEQVQRDFVKLSQTLQVQLERIRQADSLE 842
            +E+ Q     L    Q QLE   +A+ L+
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLK 2386



 Score =  101 bits (252), Expect = 3e-21
 Identities = 176/861 (20%), Positives = 352/861 (40%), Gaps = 128/861 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1884 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2003

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 2004 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2063

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2124 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2230

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D                        
Sbjct: 2231 ----FSVRVQMEE--LSKLKARIEAENRALILRDKD-----------------------N 2261

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS-GFMLTKD 471
            T   LQ +A      A+ A  L        V A   +     A     Q  +    + K+
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGR 531
            + +A++  T  + E   L        E A                 LQ++      +L  
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQKELAQEQA---------------RRLQEDKEQMAQQLAE 2359

Query: 532  RCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSED 591
                   +++ L+  + ++ E   + ++L+L + + +    +  +D Q      ++ +E+
Sbjct: 2360 ETQ---GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF----RKQAEE 2412

Query: 592  SSHQISALVLRAQASEILLEELQQGLSQAKRDVQ---EQMAVLMQSREQVSEELVRLQKD 648
               ++    L  Q    L++ L+    Q+  D +   E +A L + +E++ +E   LQ  
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472

Query: 649  NDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILF 708
            ++ +Q       ++QQ +   L   T+AL++  L  ++ ++      +  +EK K E LF
Sbjct: 2473 SEEMQ-------TVQQEQ---LLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLF 2520

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQ 768
              E  +A+Q  +E   +  Q+E E  +        L A +E  +  + + E  +R K ++
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQR--------LVASMEEARRRQHEAEEGVRRKQEE 2572

Query: 769  LESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 828
            L+ L       E+Q +++       E+L+ EE    QRL+ +L + E+  R    L+ + 
Sbjct: 2573 LQQL-------EQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHR--AALAHSE 2613

Query: 829  QVQLERIRQADSLERIRAILN 849
            +V   ++    +L   R  L+
Sbjct: 2614 EVTASQVAATKTLPNGRDALD 2634



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 170/827 (20%), Positives = 317/827 (38%), Gaps = 134/827 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 2010

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2179

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2180 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2225

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2286 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2322

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2323 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2364

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2413

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2470

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2531 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2583

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQL 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     + 
Sbjct: 2584 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2640

Query: 759  E-----STLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEE 800
            E       LR K    + LQE  I   E+L++      TV++L   E
Sbjct: 2641 EPEHSFDGLRRK-VSAQRLQEAGILSAEELQRLAQGHTTVDELARRE 2686



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 174/828 (21%), Positives = 336/828 (40%), Gaps = 96/828 (11%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1083

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143

Query: 193  KEIAALKDKLTEAE---DKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A+   +++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1199

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++       L   R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1200 RELEQLGRQ-------LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1253 -ALLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1307

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1363

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETAS 488
            +    L++     L  A + ++         LQ      + + +E A+ A   ++     
Sbjct: 1364 EVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1420

Query: 489  LLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI 548
             L  + Q  E+   + +     +E     +++E+     +L          E +LQ ++ 
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480

Query: 549  Q----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL----V 600
            +    EA+ R   ++ + + RQ  D+ ++  + + EL   +K  +E +  +  AL     
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 601  LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHS-LH 659
            LR QA     EE ++ L QA+ +   Q+ V +++ ++ +E    LQ    S   K + L 
Sbjct: 1541 LRLQA-----EEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASFAEKTAQLE 1593

Query: 660  VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEIL----FLKEQIQA 715
             SLQ+    +       LRE   +  +       A +  E +L+   L     L+ ++QA
Sbjct: 1594 RSLQEEHVAV-----AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQL-ESLQE 774
            E+  ++  +   Q E E  KEE    +  + + E   V + +L     EK +QL E   +
Sbjct: 1649 EEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706

Query: 775  IKISLEEQ---LKKETAAKATVEQLMFEEKNKAQR------------------LQTELDV 813
             +++ E++   L+ ET       QL+ EE  + QR                  ++ E++V
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766

Query: 814  --------SEQVQRDFVKLSQTLQVQLERIRQ-ADSLERIRAILNDTK 852
                     E+ +    K  Q L+ +  R R+ A+   R+RA+  + K
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 86/463 (18%), Positives = 186/463 (40%), Gaps = 97/463 (20%)

Query: 450  ENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL 509
            E  +T ++  L++P    L K+  R       EQ++  + +  + +G+          RL
Sbjct: 997  EACETRTVHRLRLP----LDKEPARECAQRIAEQQKAQAEVEGLGKGVA---------RL 1043

Query: 510  VSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQAND 569
             +E E  L   E   A   L    ++     +Q++ +    A   +++K + L++R    
Sbjct: 1044 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS---AIYLEKLKTISLVIRGTQG 1100

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
              E     +++L++         +  + A +   +A++  L++L+   ++A++   + + 
Sbjct: 1101 AEEVLRAHEEQLKE---------AQAVPATLPELEATKASLKKLR-AQAEAQQPTFDALR 1150

Query: 630  VLMQSREQVSEELVRLQKDND-SLQGKHSLHVSLQQAEDFILPDTTEALREL------VL 682
              ++  ++V E L +   + D  ++        L +    +L  T    REL      + 
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210

Query: 683  KYRED-------IINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENC- 734
             YRE        + + R   + ++    A+   ++EQ++ EQ L E +E   + ++E C 
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQ 1269

Query: 735  ----------KEEIASISSLKAELERI-------KVEKGQ-------------------- 757
                      K+    + + KA+LE +       KV+ G                     
Sbjct: 1270 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1329

Query: 758  -------LESTLR-----------EKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
                   +  TLR           +++++ E L E++ +LE+Q +   A      Q   E
Sbjct: 1330 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1389

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 842
             K   QR+Q E+   E+   D  +  +++Q +L+++RQ+   E
Sbjct: 1390 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1432


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  110 bits (275), Expect = 6e-24
 Identities = 175/884 (19%), Positives = 376/884 (42%), Gaps = 95/884 (10%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1303 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1362

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1363 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEG-----QEEENLENEMKKAQEDAEKLRS 186
              +RL+ E T+  + R  AE E+  LR R  E      Q +E  E   ++ Q+++++ R 
Sbjct: 1423 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1480

Query: 187  VVMPMEKEIAA-----------------LKDKLTEAEDKIKELEASKVKELNHYLE-AEK 228
              + +   + A                 L+ +  EAE ++++ E  + +++   LE A++
Sbjct: 1481 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1540

Query: 229  SCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFL 288
            S   +L+   A    + + L+     L++E   V  L E+  ++  Q     +   +   
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597

Query: 289  ESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPV 348
            E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE+     
Sbjct: 1598 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEEQ----- 1650

Query: 349  VCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKDGLRRAQ 406
              A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++ L R Q
Sbjct: 1651 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1708

Query: 407  STDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSG- 465
               +  T    + +A     +A+      E        A+  S +    S   L+  +G 
Sbjct: 1709 REAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRLEAEAGR 1763

Query: 466  FMLTKDQERAIKAMTPEQ-------EETASLLSSVTQGMESAYVSPSGY--RLVSETEWN 516
            F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL +E E  
Sbjct: 1764 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823

Query: 517  LLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ------ 570
            L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D       
Sbjct: 1824 LKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1878

Query: 571  --LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQA 620
              +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q  L  A
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938

Query: 621  KRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL 680
            +   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     EA R  
Sbjct: 1939 R---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 1993

Query: 681  VLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS 740
                +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ E     +    
Sbjct: 1994 ERAEQESARQLQLAQEAAQKRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2050

Query: 741  ISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE- 799
              + +   E  +  + Q E    +  +Q+E  + +K S EEQ +    A+A  E+L  E 
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2110

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
            E+  A+R Q E     Q Q    ++ +  +   + +RQ   +E+
Sbjct: 2111 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2154



 Score =  108 bits (270), Expect = 2e-23
 Identities = 178/883 (20%), Positives = 366/883 (41%), Gaps = 114/883 (12%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1818

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1819 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1873

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1874 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1924

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 1985 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2037

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2038 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2095

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2096 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2150

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2151 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2195

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2196 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2251

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMA-------------VLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2252 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2311

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2371

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL 748
               R  A+ + EKL    L  +E++         L +TL+++ +    +   +    AEL
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKV--------TLVQTLEIQRQQSDHDAERLREAIAEL 2423

Query: 749  ERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKN----KA 804
            ER K +  Q    L+ KS++++++Q      +EQL +ET A   ++Q    EK+    + 
Sbjct: 2424 EREKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQA---LQQSFLSEKDSLLQRE 2474

Query: 805  QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAI 847
            + ++ E    EQ+ +D V  +Q L+ + +R +Q    ER R +
Sbjct: 2475 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517



 Score =  106 bits (264), Expect = 1e-22
 Identities = 181/869 (20%), Positives = 364/869 (41%), Gaps = 77/869 (8%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1522 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1581

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1582 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1639

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1756

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1757 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1814

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1868

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1927

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1987

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 1988 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2106

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2107 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2158

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2159 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2211

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL---ERIKV 753
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+  + +      E +  
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2271

Query: 754  EKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDV 813
            ++   E  L+EK Q ++    +K   E   +++  A+    +L  +++  AQ+L      
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL------ 2325

Query: 814  SEQVQRDFVKLSQTLQVQLERIRQADSLE 842
            +E+ Q     L    Q QLE   +A+ L+
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLK 2354



 Score =  101 bits (252), Expect = 3e-21
 Identities = 176/861 (20%), Positives = 352/861 (40%), Gaps = 128/861 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1852 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1911

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1912 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1971

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 1972 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2031

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2032 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2092 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2198

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D                        
Sbjct: 2199 ----FSVRVQMEE--LSKLKARIEAENRALILRDKD-----------------------N 2229

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS-GFMLTKD 471
            T   LQ +A      A+ A  L        V A   +     A     Q  +    + K+
Sbjct: 2230 TQRFLQEEAEKMKQVAEEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKE 2282

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGR 531
            + +A++  T  + E   L        E A                 LQ++      +L  
Sbjct: 2283 KMQAVQEATRLKAEAELLQQQKELAQEQA---------------RRLQEDKEQMAQQLAE 2327

Query: 532  RCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSED 591
                   +++ L+  + ++ E   + ++L+L + + +    +  +D Q      ++ +E+
Sbjct: 2328 ETQ---GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF----RKQAEE 2380

Query: 592  SSHQISALVLRAQASEILLEELQQGLSQAKRDVQ---EQMAVLMQSREQVSEELVRLQKD 648
               ++    L  Q    L++ L+    Q+  D +   E +A L + +E++ +E   LQ  
Sbjct: 2381 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440

Query: 649  NDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILF 708
            ++ +Q       ++QQ +   L   T+AL++  L  ++ ++      +  +EK K E LF
Sbjct: 2441 SEEMQ-------TVQQEQ---LLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLF 2488

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQ 768
              E  +A+Q  +E   +  Q+E E  +        L A +E  +  + + E  +R K ++
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQR--------LVASMEEARRRQHEAEEGVRRKQEE 2540

Query: 769  LESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 828
            L+ L       E+Q +++       E+L+ EE    QRL+ +L + E+  R    L+ + 
Sbjct: 2541 LQQL-------EQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHR--AALAHSE 2581

Query: 829  QVQLERIRQADSLERIRAILN 849
            +V   ++    +L   R  L+
Sbjct: 2582 EVTASQVAATKTLPNGRDALD 2602



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 170/827 (20%), Positives = 317/827 (38%), Gaps = 134/827 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 1978

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 1979 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2036

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2097 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2147

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2148 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2193

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2194 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2253

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2254 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2290

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2291 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2332

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2333 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2381

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2438

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2498

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2499 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2551

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQL 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     + 
Sbjct: 2552 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2608

Query: 759  E-----STLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEE 800
            E       LR K    + LQE  I   E+L++      TV++L   E
Sbjct: 2609 EPEHSFDGLRRK-VSAQRLQEAGILSAEELQRLAQGHTTVDELARRE 2654



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 174/828 (21%), Positives = 336/828 (40%), Gaps = 96/828 (11%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 996  KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1051

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1052 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1111

Query: 193  KEIAALKDKLTEAE---DKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A+   +++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1112 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1167

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++       L   R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1168 RELEQLGRQ-------LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1220

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1221 -ALLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1275

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1276 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1331

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETAS 488
            +    L++     L  A + ++         LQ      + + +E A+ A   ++     
Sbjct: 1332 EVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1388

Query: 489  LLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI 548
             L  + Q  E+   + +     +E     +++E+     +L          E +LQ ++ 
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1448

Query: 549  Q----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL----V 600
            +    EA+ R   ++ + + RQ  D+ ++  + + EL   +K  +E +  +  AL     
Sbjct: 1449 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1508

Query: 601  LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHS-LH 659
            LR QA     EE ++ L QA+ +   Q+ V +++ ++ +E    LQ    S   K + L 
Sbjct: 1509 LRLQA-----EEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASFAEKTAQLE 1561

Query: 660  VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEIL----FLKEQIQA 715
             SLQ+    +       LRE   +  +       A +  E +L+   L     L+ ++QA
Sbjct: 1562 RSLQEEHVAV-----AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQL-ESLQE 774
            E+  ++  +   Q E E  KEE    +  + + E   V + +L     EK +QL E   +
Sbjct: 1617 EEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1674

Query: 775  IKISLEEQ---LKKETAAKATVEQLMFEEKNKAQR------------------LQTELDV 813
             +++ E++   L+ ET       QL+ EE  + QR                  ++ E++V
Sbjct: 1675 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1734

Query: 814  --------SEQVQRDFVKLSQTLQVQLERIRQ-ADSLERIRAILNDTK 852
                     E+ +    K  Q L+ +  R R+ A+   R+RA+  + K
Sbjct: 1735 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 86/463 (18%), Positives = 186/463 (40%), Gaps = 97/463 (20%)

Query: 450  ENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL 509
            E  +T ++  L++P    L K+  R       EQ++  + +  + +G+          RL
Sbjct: 965  EACETRTVHRLRLP----LDKEPARECAQRIAEQQKAQAEVEGLGKGVA---------RL 1011

Query: 510  VSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQAND 569
             +E E  L   E   A   L    ++     +Q++ +    A   +++K + L++R    
Sbjct: 1012 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS---AIYLEKLKTISLVIRGTQG 1068

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
              E     +++L++         +  + A +   +A++  L++L+   ++A++   + + 
Sbjct: 1069 AEEVLRAHEEQLKE---------AQAVPATLPELEATKASLKKLR-AQAEAQQPTFDALR 1118

Query: 630  VLMQSREQVSEELVRLQKDND-SLQGKHSLHVSLQQAEDFILPDTTEALREL------VL 682
              ++  ++V E L +   + D  ++        L +    +L  T    REL      + 
Sbjct: 1119 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1178

Query: 683  KYRED-------IINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENC- 734
             YRE        + + R   + ++    A+   ++EQ++ EQ L E +E   + ++E C 
Sbjct: 1179 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQ 1237

Query: 735  ----------KEEIASISSLKAELERI-------KVEKGQ-------------------- 757
                      K+    + + KA+LE +       KV+ G                     
Sbjct: 1238 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1297

Query: 758  -------LESTLR-----------EKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
                   +  TLR           +++++ E L E++ +LE+Q +   A      Q   E
Sbjct: 1298 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1357

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 842
             K   QR+Q E+   E+   D  +  +++Q +L+++RQ+   E
Sbjct: 1358 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1400


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  110 bits (275), Expect = 6e-24
 Identities = 175/884 (19%), Positives = 376/884 (42%), Gaps = 95/884 (10%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1472 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1531

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1532 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEG-----QEEENLENEMKKAQEDAEKLRS 186
              +RL+ E T+  + R  AE E+  LR R  E      Q +E  E   ++ Q+++++ R 
Sbjct: 1592 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1649

Query: 187  VVMPMEKEIAA-----------------LKDKLTEAEDKIKELEASKVKELNHYLE-AEK 228
              + +   + A                 L+ +  EAE ++++ E  + +++   LE A++
Sbjct: 1650 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1709

Query: 229  SCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFL 288
            S   +L+   A    + + L+     L++E   V  L E+  ++  Q     +   +   
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766

Query: 289  ESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPV 348
            E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE+     
Sbjct: 1767 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEEQ----- 1819

Query: 349  VCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKDGLRRAQ 406
              A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++ L R Q
Sbjct: 1820 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1877

Query: 407  STDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSG- 465
               +  T    + +A     +A+      E        A+  S +    S   L+  +G 
Sbjct: 1878 REAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRLEAEAGR 1932

Query: 466  FMLTKDQERAIKAMTPEQ-------EETASLLSSVTQGMESAYVSPSGY--RLVSETEWN 516
            F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL +E E  
Sbjct: 1933 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992

Query: 517  LLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ------ 570
            L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D       
Sbjct: 1993 LKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 2047

Query: 571  --LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQA 620
              +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q  L  A
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107

Query: 621  KRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL 680
            +   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     EA R  
Sbjct: 2108 R---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2162

Query: 681  VLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS 740
                +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ E     +    
Sbjct: 2163 ERAEQESARQLQLAQEAAQKRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2219

Query: 741  ISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE- 799
              + +   E  +  + Q E    +  +Q+E  + +K S EEQ +    A+A  E+L  E 
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2279

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
            E+  A+R Q E     Q Q    ++ +  +   + +RQ   +E+
Sbjct: 2280 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2323



 Score =  108 bits (270), Expect = 2e-23
 Identities = 178/883 (20%), Positives = 366/883 (41%), Gaps = 114/883 (12%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1987

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1988 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 2042

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 2043 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 2093

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2153

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2154 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2206

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2207 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2264

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2319

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2320 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2364

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2365 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMA-------------VLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2421 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2540

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL 748
               R  A+ + EKL    L  +E++         L +TL+++ +    +   +    AEL
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKV--------TLVQTLEIQRQQSDHDAERLREAIAEL 2592

Query: 749  ERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKN----KA 804
            ER K +  Q    L+ KS++++++Q      +EQL +ET A   ++Q    EK+    + 
Sbjct: 2593 EREKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQA---LQQSFLSEKDSLLQRE 2643

Query: 805  QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAI 847
            + ++ E    EQ+ +D V  +Q L+ + +R +Q    ER R +
Sbjct: 2644 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686



 Score =  106 bits (264), Expect = 1e-22
 Identities = 181/869 (20%), Positives = 364/869 (41%), Gaps = 77/869 (8%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1691 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1751 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1808

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1925

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1983

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 2037

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 2096

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2156

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2157 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2275

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2276 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2327

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2328 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2380

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL---ERIKV 753
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+  + +      E +  
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2440

Query: 754  EKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDV 813
            ++   E  L+EK Q ++    +K   E   +++  A+    +L  +++  AQ+L      
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL------ 2494

Query: 814  SEQVQRDFVKLSQTLQVQLERIRQADSLE 842
            +E+ Q     L    Q QLE   +A+ L+
Sbjct: 2495 AEETQGFQRTLEAERQRQLEMSAEAERLK 2523



 Score =  101 bits (252), Expect = 3e-21
 Identities = 176/861 (20%), Positives = 352/861 (40%), Gaps = 128/861 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 2021 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 2080

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 2081 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2140

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 2141 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2200

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2261 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2367

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D                        
Sbjct: 2368 ----FSVRVQMEE--LSKLKARIEAENRALILRDKD-----------------------N 2398

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS-GFMLTKD 471
            T   LQ +A      A+ A  L        V A   +     A     Q  +    + K+
Sbjct: 2399 TQRFLQEEAEKMKQVAEEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKE 2451

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGR 531
            + +A++  T  + E   L        E A                 LQ++      +L  
Sbjct: 2452 KMQAVQEATRLKAEAELLQQQKELAQEQA---------------RRLQEDKEQMAQQLAE 2496

Query: 532  RCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSED 591
                   +++ L+  + ++ E   + ++L+L + + +    +  +D Q      ++ +E+
Sbjct: 2497 ETQ---GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF----RKQAEE 2549

Query: 592  SSHQISALVLRAQASEILLEELQQGLSQAKRDVQ---EQMAVLMQSREQVSEELVRLQKD 648
               ++    L  Q    L++ L+    Q+  D +   E +A L + +E++ +E   LQ  
Sbjct: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609

Query: 649  NDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILF 708
            ++ +Q       ++QQ +   L   T+AL++  L  ++ ++      +  +EK K E LF
Sbjct: 2610 SEEMQ-------TVQQEQ---LLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLF 2657

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQ 768
              E  +A+Q  +E   +  Q+E E  +        L A +E  +  + + E  +R K ++
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQR--------LVASMEEARRRQHEAEEGVRRKQEE 2709

Query: 769  LESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 828
            L+ L       E+Q +++       E+L+ EE    QRL+ +L + E+  R    L+ + 
Sbjct: 2710 LQQL-------EQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHR--AALAHSE 2750

Query: 829  QVQLERIRQADSLERIRAILN 849
            +V   ++    +L   R  L+
Sbjct: 2751 EVTASQVAATKTLPNGRDALD 2771



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 170/827 (20%), Positives = 317/827 (38%), Gaps = 134/827 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 2147

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2205

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2266 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2316

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2317 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2362

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2363 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2422

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2423 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2459

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2460 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2501

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2502 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2550

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2607

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2667

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2668 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2720

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQL 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     + 
Sbjct: 2721 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2777

Query: 759  E-----STLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEE 800
            E       LR K    + LQE  I   E+L++      TV++L   E
Sbjct: 2778 EPEHSFDGLRRK-VSAQRLQEAGILSAEELQRLAQGHTTVDELARRE 2823



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 174/828 (21%), Positives = 336/828 (40%), Gaps = 96/828 (11%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1165 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1220

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1221 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1280

Query: 193  KEIAALKDKLTEAE---DKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A+   +++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1281 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1336

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++       L   R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1337 RELEQLGRQ-------LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1389

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1390 -ALLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1444

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1445 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1500

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETAS 488
            +    L++     L  A + ++         LQ      + + +E A+ A   ++     
Sbjct: 1501 EVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1557

Query: 489  LLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI 548
             L  + Q  E+   + +     +E     +++E+     +L          E +LQ ++ 
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1617

Query: 549  Q----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL----V 600
            +    EA+ R   ++ + + RQ  D+ ++  + + EL   +K  +E +  +  AL     
Sbjct: 1618 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677

Query: 601  LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHS-LH 659
            LR QA     EE ++ L QA+ +   Q+ V +++ ++ +E    LQ    S   K + L 
Sbjct: 1678 LRLQA-----EEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASFAEKTAQLE 1730

Query: 660  VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEIL----FLKEQIQA 715
             SLQ+    +       LRE   +  +       A +  E +L+   L     L+ ++QA
Sbjct: 1731 RSLQEEHVAV-----AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQL-ESLQE 774
            E+  ++  +   Q E E  KEE    +  + + E   V + +L     EK +QL E   +
Sbjct: 1786 EEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843

Query: 775  IKISLEEQ---LKKETAAKATVEQLMFEEKNKAQR------------------LQTELDV 813
             +++ E++   L+ ET       QL+ EE  + QR                  ++ E++V
Sbjct: 1844 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1903

Query: 814  --------SEQVQRDFVKLSQTLQVQLERIRQ-ADSLERIRAILNDTK 852
                     E+ +    K  Q L+ +  R R+ A+   R+RA+  + K
Sbjct: 1904 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 86/463 (18%), Positives = 186/463 (40%), Gaps = 97/463 (20%)

Query: 450  ENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL 509
            E  +T ++  L++P    L K+  R       EQ++  + +  + +G+          RL
Sbjct: 1134 EACETRTVHRLRLP----LDKEPARECAQRIAEQQKAQAEVEGLGKGVA---------RL 1180

Query: 510  VSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQAND 569
             +E E  L   E   A   L    ++     +Q++ +    A   +++K + L++R    
Sbjct: 1181 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS---AIYLEKLKTISLVIRGTQG 1237

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
              E     +++L++         +  + A +   +A++  L++L+   ++A++   + + 
Sbjct: 1238 AEEVLRAHEEQLKE---------AQAVPATLPELEATKASLKKLR-AQAEAQQPTFDALR 1287

Query: 630  VLMQSREQVSEELVRLQKDND-SLQGKHSLHVSLQQAEDFILPDTTEALREL------VL 682
              ++  ++V E L +   + D  ++        L +    +L  T    REL      + 
Sbjct: 1288 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1347

Query: 683  KYRED-------IINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENC- 734
             YRE        + + R   + ++    A+   ++EQ++ EQ L E +E   + ++E C 
Sbjct: 1348 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQ 1406

Query: 735  ----------KEEIASISSLKAELERI-------KVEKGQ-------------------- 757
                      K+    + + KA+LE +       KV+ G                     
Sbjct: 1407 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1466

Query: 758  -------LESTLR-----------EKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
                   +  TLR           +++++ E L E++ +LE+Q +   A      Q   E
Sbjct: 1467 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1526

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 842
             K   QR+Q E+   E+   D  +  +++Q +L+++RQ+   E
Sbjct: 1527 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1569


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  110 bits (275), Expect = 6e-24
 Identities = 175/884 (19%), Positives = 376/884 (42%), Gaps = 95/884 (10%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1313 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1372

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1373 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEG-----QEEENLENEMKKAQEDAEKLRS 186
              +RL+ E T+  + R  AE E+  LR R  E      Q +E  E   ++ Q+++++ R 
Sbjct: 1433 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1490

Query: 187  VVMPMEKEIAA-----------------LKDKLTEAEDKIKELEASKVKELNHYLE-AEK 228
              + +   + A                 L+ +  EAE ++++ E  + +++   LE A++
Sbjct: 1491 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1550

Query: 229  SCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFL 288
            S   +L+   A    + + L+     L++E   V  L E+  ++  Q     +   +   
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607

Query: 289  ESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPV 348
            E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE+     
Sbjct: 1608 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEEQ----- 1660

Query: 349  VCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKDGLRRAQ 406
              A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++ L R Q
Sbjct: 1661 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1718

Query: 407  STDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSG- 465
               +  T    + +A     +A+      E        A+  S +    S   L+  +G 
Sbjct: 1719 REAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRLEAEAGR 1773

Query: 466  FMLTKDQERAIKAMTPEQ-------EETASLLSSVTQGMESAYVSPSGY--RLVSETEWN 516
            F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL +E E  
Sbjct: 1774 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833

Query: 517  LLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ------ 570
            L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D       
Sbjct: 1834 LKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1888

Query: 571  --LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQA 620
              +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q  L  A
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948

Query: 621  KRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL 680
            +   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     EA R  
Sbjct: 1949 R---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2003

Query: 681  VLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS 740
                +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ E     +    
Sbjct: 2004 ERAEQESARQLQLAQEAAQKRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2060

Query: 741  ISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE- 799
              + +   E  +  + Q E    +  +Q+E  + +K S EEQ +    A+A  E+L  E 
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2120

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
            E+  A+R Q E     Q Q    ++ +  +   + +RQ   +E+
Sbjct: 2121 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2164



 Score =  108 bits (270), Expect = 2e-23
 Identities = 178/883 (20%), Positives = 366/883 (41%), Gaps = 114/883 (12%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1828

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1829 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1883

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1884 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1934

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 1995 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2047

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2048 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2105

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2106 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2160

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2161 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2205

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2206 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMA-------------VLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2262 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2321

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2381

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL 748
               R  A+ + EKL    L  +E++         L +TL+++ +    +   +    AEL
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKV--------TLVQTLEIQRQQSDHDAERLREAIAEL 2433

Query: 749  ERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKN----KA 804
            ER K +  Q    L+ KS++++++Q      +EQL +ET A   ++Q    EK+    + 
Sbjct: 2434 EREKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQA---LQQSFLSEKDSLLQRE 2484

Query: 805  QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAI 847
            + ++ E    EQ+ +D V  +Q L+ + +R +Q    ER R +
Sbjct: 2485 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527



 Score =  106 bits (264), Expect = 1e-22
 Identities = 181/869 (20%), Positives = 364/869 (41%), Gaps = 77/869 (8%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1532 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1592 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1649

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1766

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1824

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1878

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1937

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1997

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 1998 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2116

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2117 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2168

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2169 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2221

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL---ERIKV 753
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+  + +      E +  
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2281

Query: 754  EKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDV 813
            ++   E  L+EK Q ++    +K   E   +++  A+    +L  +++  AQ+L      
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL------ 2335

Query: 814  SEQVQRDFVKLSQTLQVQLERIRQADSLE 842
            +E+ Q     L    Q QLE   +A+ L+
Sbjct: 2336 AEETQGFQRTLEAERQRQLEMSAEAERLK 2364



 Score =  101 bits (252), Expect = 3e-21
 Identities = 176/861 (20%), Positives = 352/861 (40%), Gaps = 128/861 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1862 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1921

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1922 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1981

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 1982 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2041

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2102 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2208

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D                        
Sbjct: 2209 ----FSVRVQMEE--LSKLKARIEAENRALILRDKD-----------------------N 2239

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS-GFMLTKD 471
            T   LQ +A      A+ A  L        V A   +     A     Q  +    + K+
Sbjct: 2240 TQRFLQEEAEKMKQVAEEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKE 2292

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGR 531
            + +A++  T  + E   L        E A                 LQ++      +L  
Sbjct: 2293 KMQAVQEATRLKAEAELLQQQKELAQEQA---------------RRLQEDKEQMAQQLAE 2337

Query: 532  RCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSED 591
                   +++ L+  + ++ E   + ++L+L + + +    +  +D Q      ++ +E+
Sbjct: 2338 ETQ---GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF----RKQAEE 2390

Query: 592  SSHQISALVLRAQASEILLEELQQGLSQAKRDVQ---EQMAVLMQSREQVSEELVRLQKD 648
               ++    L  Q    L++ L+    Q+  D +   E +A L + +E++ +E   LQ  
Sbjct: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2450

Query: 649  NDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILF 708
            ++ +Q       ++QQ +   L   T+AL++  L  ++ ++      +  +EK K E LF
Sbjct: 2451 SEEMQ-------TVQQEQ---LLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLF 2498

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQ 768
              E  +A+Q  +E   +  Q+E E  +        L A +E  +  + + E  +R K ++
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQR--------LVASMEEARRRQHEAEEGVRRKQEE 2550

Query: 769  LESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 828
            L+ L       E+Q +++       E+L+ EE    QRL+ +L + E+  R    L+ + 
Sbjct: 2551 LQQL-------EQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHR--AALAHSE 2591

Query: 829  QVQLERIRQADSLERIRAILN 849
            +V   ++    +L   R  L+
Sbjct: 2592 EVTASQVAATKTLPNGRDALD 2612



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 170/827 (20%), Positives = 317/827 (38%), Gaps = 134/827 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 1988

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 1989 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2046

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2107 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2157

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2158 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2203

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2204 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2263

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2264 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2300

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2301 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2342

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2343 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2391

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2448

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2508

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2509 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2561

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQL 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     + 
Sbjct: 2562 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2618

Query: 759  E-----STLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEE 800
            E       LR K    + LQE  I   E+L++      TV++L   E
Sbjct: 2619 EPEHSFDGLRRK-VSAQRLQEAGILSAEELQRLAQGHTTVDELARRE 2664



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 174/828 (21%), Positives = 336/828 (40%), Gaps = 96/828 (11%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1006 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1061

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1062 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1121

Query: 193  KEIAALKDKLTEAE---DKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A+   +++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1122 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1177

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++       L   R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1178 RELEQLGRQ-------LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1230

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1231 -ALLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1285

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1286 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1341

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETAS 488
            +    L++     L  A + ++         LQ      + + +E A+ A   ++     
Sbjct: 1342 EVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1398

Query: 489  LLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI 548
             L  + Q  E+   + +     +E     +++E+     +L          E +LQ ++ 
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1458

Query: 549  Q----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL----V 600
            +    EA+ R   ++ + + RQ  D+ ++  + + EL   +K  +E +  +  AL     
Sbjct: 1459 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1518

Query: 601  LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHS-LH 659
            LR QA     EE ++ L QA+ +   Q+ V +++ ++ +E    LQ    S   K + L 
Sbjct: 1519 LRLQA-----EEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASFAEKTAQLE 1571

Query: 660  VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEIL----FLKEQIQA 715
             SLQ+    +       LRE   +  +       A +  E +L+   L     L+ ++QA
Sbjct: 1572 RSLQEEHVAV-----AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQL-ESLQE 774
            E+  ++  +   Q E E  KEE    +  + + E   V + +L     EK +QL E   +
Sbjct: 1627 EEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684

Query: 775  IKISLEEQ---LKKETAAKATVEQLMFEEKNKAQR------------------LQTELDV 813
             +++ E++   L+ ET       QL+ EE  + QR                  ++ E++V
Sbjct: 1685 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1744

Query: 814  --------SEQVQRDFVKLSQTLQVQLERIRQ-ADSLERIRAILNDTK 852
                     E+ +    K  Q L+ +  R R+ A+   R+RA+  + K
Sbjct: 1745 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 86/463 (18%), Positives = 186/463 (40%), Gaps = 97/463 (20%)

Query: 450  ENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL 509
            E  +T ++  L++P    L K+  R       EQ++  + +  + +G+          RL
Sbjct: 975  EACETRTVHRLRLP----LDKEPARECAQRIAEQQKAQAEVEGLGKGVA---------RL 1021

Query: 510  VSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQAND 569
             +E E  L   E   A   L    ++     +Q++ +    A   +++K + L++R    
Sbjct: 1022 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS---AIYLEKLKTISLVIRGTQG 1078

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
              E     +++L++         +  + A +   +A++  L++L+   ++A++   + + 
Sbjct: 1079 AEEVLRAHEEQLKE---------AQAVPATLPELEATKASLKKLR-AQAEAQQPTFDALR 1128

Query: 630  VLMQSREQVSEELVRLQKDND-SLQGKHSLHVSLQQAEDFILPDTTEALREL------VL 682
              ++  ++V E L +   + D  ++        L +    +L  T    REL      + 
Sbjct: 1129 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1188

Query: 683  KYRED-------IINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENC- 734
             YRE        + + R   + ++    A+   ++EQ++ EQ L E +E   + ++E C 
Sbjct: 1189 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQ 1247

Query: 735  ----------KEEIASISSLKAELERI-------KVEKGQ-------------------- 757
                      K+    + + KA+LE +       KV+ G                     
Sbjct: 1248 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1307

Query: 758  -------LESTLR-----------EKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
                   +  TLR           +++++ E L E++ +LE+Q +   A      Q   E
Sbjct: 1308 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1367

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 842
             K   QR+Q E+   E+   D  +  +++Q +L+++RQ+   E
Sbjct: 1368 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1410


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  110 bits (275), Expect = 6e-24
 Identities = 175/884 (19%), Positives = 376/884 (42%), Gaps = 95/884 (10%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1321 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1380

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1381 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEG-----QEEENLENEMKKAQEDAEKLRS 186
              +RL+ E T+  + R  AE E+  LR R  E      Q +E  E   ++ Q+++++ R 
Sbjct: 1441 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1498

Query: 187  VVMPMEKEIAA-----------------LKDKLTEAEDKIKELEASKVKELNHYLE-AEK 228
              + +   + A                 L+ +  EAE ++++ E  + +++   LE A++
Sbjct: 1499 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1558

Query: 229  SCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFL 288
            S   +L+   A    + + L+     L++E   V  L E+  ++  Q     +   +   
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615

Query: 289  ESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPV 348
            E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE+     
Sbjct: 1616 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEEQ----- 1668

Query: 349  VCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKDGLRRAQ 406
              A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++ L R Q
Sbjct: 1669 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1726

Query: 407  STDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSG- 465
               +  T    + +A     +A+      E        A+  S +    S   L+  +G 
Sbjct: 1727 REAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRLEAEAGR 1781

Query: 466  FMLTKDQERAIKAMTPEQ-------EETASLLSSVTQGMESAYVSPSGY--RLVSETEWN 516
            F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL +E E  
Sbjct: 1782 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841

Query: 517  LLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ------ 570
            L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D       
Sbjct: 1842 LKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1896

Query: 571  --LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQA 620
              +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q  L  A
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956

Query: 621  KRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL 680
            +   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     EA R  
Sbjct: 1957 R---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2011

Query: 681  VLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS 740
                +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ E     +    
Sbjct: 2012 ERAEQESARQLQLAQEAAQKRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2068

Query: 741  ISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE- 799
              + +   E  +  + Q E    +  +Q+E  + +K S EEQ +    A+A  E+L  E 
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2128

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
            E+  A+R Q E     Q Q    ++ +  +   + +RQ   +E+
Sbjct: 2129 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2172



 Score =  108 bits (270), Expect = 2e-23
 Identities = 178/883 (20%), Positives = 366/883 (41%), Gaps = 114/883 (12%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1777

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1836

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1837 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1891

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1892 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1942

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2002

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2003 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2055

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2056 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2113

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2114 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2168

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2169 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2213

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2214 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2269

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMA-------------VLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2270 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2329

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2389

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL 748
               R  A+ + EKL    L  +E++         L +TL+++ +    +   +    AEL
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKV--------TLVQTLEIQRQQSDHDAERLREAIAEL 2441

Query: 749  ERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKN----KA 804
            ER K +  Q    L+ KS++++++Q      +EQL +ET A   ++Q    EK+    + 
Sbjct: 2442 EREKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQA---LQQSFLSEKDSLLQRE 2492

Query: 805  QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAI 847
            + ++ E    EQ+ +D V  +Q L+ + +R +Q    ER R +
Sbjct: 2493 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535



 Score =  106 bits (264), Expect = 1e-22
 Identities = 181/869 (20%), Positives = 364/869 (41%), Gaps = 77/869 (8%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1540 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1599

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1600 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1657

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1716

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1774

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1775 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1832

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1886

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1945

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2005

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2006 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2124

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2125 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2176

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2177 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2229

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL---ERIKV 753
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+  + +      E +  
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2289

Query: 754  EKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDV 813
            ++   E  L+EK Q ++    +K   E   +++  A+    +L  +++  AQ+L      
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL------ 2343

Query: 814  SEQVQRDFVKLSQTLQVQLERIRQADSLE 842
            +E+ Q     L    Q QLE   +A+ L+
Sbjct: 2344 AEETQGFQRTLEAERQRQLEMSAEAERLK 2372



 Score =  101 bits (252), Expect = 3e-21
 Identities = 176/861 (20%), Positives = 352/861 (40%), Gaps = 128/861 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1870 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1929

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1930 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1989

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 1990 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2049

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2050 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2109

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2110 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2216

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D                        
Sbjct: 2217 ----FSVRVQMEE--LSKLKARIEAENRALILRDKD-----------------------N 2247

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS-GFMLTKD 471
            T   LQ +A      A+ A  L        V A   +     A     Q  +    + K+
Sbjct: 2248 TQRFLQEEAEKMKQVAEEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKE 2300

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGR 531
            + +A++  T  + E   L        E A                 LQ++      +L  
Sbjct: 2301 KMQAVQEATRLKAEAELLQQQKELAQEQA---------------RRLQEDKEQMAQQLAE 2345

Query: 532  RCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSED 591
                   +++ L+  + ++ E   + ++L+L + + +    +  +D Q      ++ +E+
Sbjct: 2346 ETQ---GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF----RKQAEE 2398

Query: 592  SSHQISALVLRAQASEILLEELQQGLSQAKRDVQ---EQMAVLMQSREQVSEELVRLQKD 648
               ++    L  Q    L++ L+    Q+  D +   E +A L + +E++ +E   LQ  
Sbjct: 2399 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2458

Query: 649  NDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILF 708
            ++ +Q       ++QQ +   L   T+AL++  L  ++ ++      +  +EK K E LF
Sbjct: 2459 SEEMQ-------TVQQEQ---LLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLF 2506

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQ 768
              E  +A+Q  +E   +  Q+E E  +        L A +E  +  + + E  +R K ++
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQMEQERQR--------LVASMEEARRRQHEAEEGVRRKQEE 2558

Query: 769  LESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 828
            L+ L       E+Q +++       E+L+ EE    QRL+ +L + E+  R    L+ + 
Sbjct: 2559 LQQL-------EQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHR--AALAHSE 2599

Query: 829  QVQLERIRQADSLERIRAILN 849
            +V   ++    +L   R  L+
Sbjct: 2600 EVTASQVAATKTLPNGRDALD 2620



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 170/827 (20%), Positives = 317/827 (38%), Gaps = 134/827 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 1996

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 1997 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2054

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2115 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2165

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2166 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2211

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2212 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2271

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2272 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2308

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2309 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2350

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2351 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2399

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2400 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2456

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2516

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2517 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2569

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQL 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     + 
Sbjct: 2570 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2626

Query: 759  E-----STLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEE 800
            E       LR K    + LQE  I   E+L++      TV++L   E
Sbjct: 2627 EPEHSFDGLRRK-VSAQRLQEAGILSAEELQRLAQGHTTVDELARRE 2672



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 174/828 (21%), Positives = 336/828 (40%), Gaps = 96/828 (11%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1014 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1069

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1070 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1129

Query: 193  KEIAALKDKLTEAE---DKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A+   +++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1130 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1185

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++       L   R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1186 RELEQLGRQ-------LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1238

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1239 -ALLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1293

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1294 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1349

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETAS 488
            +    L++     L  A + ++         LQ      + + +E A+ A   ++     
Sbjct: 1350 EVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1406

Query: 489  LLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI 548
             L  + Q  E+   + +     +E     +++E+     +L          E +LQ ++ 
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1466

Query: 549  Q----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL----V 600
            +    EA+ R   ++ + + RQ  D+ ++  + + EL   +K  +E +  +  AL     
Sbjct: 1467 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1526

Query: 601  LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHS-LH 659
            LR QA     EE ++ L QA+ +   Q+ V +++ ++ +E    LQ    S   K + L 
Sbjct: 1527 LRLQA-----EEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASFAEKTAQLE 1579

Query: 660  VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEIL----FLKEQIQA 715
             SLQ+    +       LRE   +  +       A +  E +L+   L     L+ ++QA
Sbjct: 1580 RSLQEEHVAV-----AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQL-ESLQE 774
            E+  ++  +   Q E E  KEE    +  + + E   V + +L     EK +QL E   +
Sbjct: 1635 EEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1692

Query: 775  IKISLEEQ---LKKETAAKATVEQLMFEEKNKAQR------------------LQTELDV 813
             +++ E++   L+ ET       QL+ EE  + QR                  ++ E++V
Sbjct: 1693 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1752

Query: 814  --------SEQVQRDFVKLSQTLQVQLERIRQ-ADSLERIRAILNDTK 852
                     E+ +    K  Q L+ +  R R+ A+   R+RA+  + K
Sbjct: 1753 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 86/463 (18%), Positives = 186/463 (40%), Gaps = 97/463 (20%)

Query: 450  ENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL 509
            E  +T ++  L++P    L K+  R       EQ++  + +  + +G+          RL
Sbjct: 983  EACETRTVHRLRLP----LDKEPARECAQRIAEQQKAQAEVEGLGKGVA---------RL 1029

Query: 510  VSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQAND 569
             +E E  L   E   A   L    ++     +Q++ +    A   +++K + L++R    
Sbjct: 1030 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS---AIYLEKLKTISLVIRGTQG 1086

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
              E     +++L++         +  + A +   +A++  L++L+   ++A++   + + 
Sbjct: 1087 AEEVLRAHEEQLKE---------AQAVPATLPELEATKASLKKLR-AQAEAQQPTFDALR 1136

Query: 630  VLMQSREQVSEELVRLQKDND-SLQGKHSLHVSLQQAEDFILPDTTEALREL------VL 682
              ++  ++V E L +   + D  ++        L +    +L  T    REL      + 
Sbjct: 1137 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1196

Query: 683  KYRED-------IINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENC- 734
             YRE        + + R   + ++    A+   ++EQ++ EQ L E +E   + ++E C 
Sbjct: 1197 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQ 1255

Query: 735  ----------KEEIASISSLKAELERI-------KVEKGQ-------------------- 757
                      K+    + + KA+LE +       KV+ G                     
Sbjct: 1256 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1315

Query: 758  -------LESTLR-----------EKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
                   +  TLR           +++++ E L E++ +LE+Q +   A      Q   E
Sbjct: 1316 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1375

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 842
             K   QR+Q E+   E+   D  +  +++Q +L+++RQ+   E
Sbjct: 1376 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1418


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  110 bits (275), Expect = 6e-24
 Identities = 175/884 (19%), Positives = 376/884 (42%), Gaps = 95/884 (10%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1362 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1421

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1422 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEG-----QEEENLENEMKKAQEDAEKLRS 186
              +RL+ E T+  + R  AE E+  LR R  E      Q +E  E   ++ Q+++++ R 
Sbjct: 1482 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1539

Query: 187  VVMPMEKEIAA-----------------LKDKLTEAEDKIKELEASKVKELNHYLE-AEK 228
              + +   + A                 L+ +  EAE ++++ E  + +++   LE A++
Sbjct: 1540 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1599

Query: 229  SCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFL 288
            S   +L+   A    + + L+     L++E   V  L E+  ++  Q     +   +   
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656

Query: 289  ESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPV 348
            E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE+     
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEEQ----- 1709

Query: 349  VCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKDGLRRAQ 406
              A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++ L R Q
Sbjct: 1710 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1767

Query: 407  STDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSG- 465
               +  T    + +A     +A+      E        A+  S +    S   L+  +G 
Sbjct: 1768 REAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRLEAEAGR 1822

Query: 466  FMLTKDQERAIKAMTPEQ-------EETASLLSSVTQGMESAYVSPSGY--RLVSETEWN 516
            F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL +E E  
Sbjct: 1823 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882

Query: 517  LLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ------ 570
            L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D       
Sbjct: 1883 LKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1937

Query: 571  --LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQA 620
              +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q  L  A
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997

Query: 621  KRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL 680
            +   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     EA R  
Sbjct: 1998 R---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2052

Query: 681  VLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS 740
                +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ E     +    
Sbjct: 2053 ERAEQESARQLQLAQEAAQKRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2109

Query: 741  ISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE- 799
              + +   E  +  + Q E    +  +Q+E  + +K S EEQ +    A+A  E+L  E 
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2169

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
            E+  A+R Q E     Q Q    ++ +  +   + +RQ   +E+
Sbjct: 2170 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2213



 Score =  108 bits (270), Expect = 2e-23
 Identities = 178/883 (20%), Positives = 366/883 (41%), Gaps = 114/883 (12%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1877

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1878 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1932

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1933 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1983

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1984 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2043

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2044 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2096

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2097 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2154

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2155 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2209

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2210 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2254

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2255 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMA-------------VLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2311 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2370

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2430

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL 748
               R  A+ + EKL    L  +E++         L +TL+++ +    +   +    AEL
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKV--------TLVQTLEIQRQQSDHDAERLREAIAEL 2482

Query: 749  ERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKN----KA 804
            ER K +  Q    L+ KS++++++Q      +EQL +ET A   ++Q    EK+    + 
Sbjct: 2483 EREKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQA---LQQSFLSEKDSLLQRE 2533

Query: 805  QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAI 847
            + ++ E    EQ+ +D V  +Q L+ + +R +Q    ER R +
Sbjct: 2534 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576



 Score =  106 bits (264), Expect = 1e-22
 Identities = 181/869 (20%), Positives = 364/869 (41%), Gaps = 77/869 (8%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1581 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1641 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1698

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1757

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1815

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1873

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1927

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1986

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1987 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2046

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2047 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2165

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2166 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2217

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2218 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2270

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL---ERIKV 753
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+  + +      E +  
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330

Query: 754  EKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDV 813
            ++   E  L+EK Q ++    +K   E   +++  A+    +L  +++  AQ+L      
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL------ 2384

Query: 814  SEQVQRDFVKLSQTLQVQLERIRQADSLE 842
            +E+ Q     L    Q QLE   +A+ L+
Sbjct: 2385 AEETQGFQRTLEAERQRQLEMSAEAERLK 2413



 Score =  101 bits (252), Expect = 3e-21
 Identities = 176/861 (20%), Positives = 352/861 (40%), Gaps = 128/861 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1911 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1970

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1971 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2030

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 2031 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2090

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2151 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2257

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D                        
Sbjct: 2258 ----FSVRVQMEE--LSKLKARIEAENRALILRDKD-----------------------N 2288

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS-GFMLTKD 471
            T   LQ +A      A+ A  L        V A   +     A     Q  +    + K+
Sbjct: 2289 TQRFLQEEAEKMKQVAEEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKE 2341

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGR 531
            + +A++  T  + E   L        E A                 LQ++      +L  
Sbjct: 2342 KMQAVQEATRLKAEAELLQQQKELAQEQA---------------RRLQEDKEQMAQQLAE 2386

Query: 532  RCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSED 591
                   +++ L+  + ++ E   + ++L+L + + +    +  +D Q      ++ +E+
Sbjct: 2387 ETQ---GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF----RKQAEE 2439

Query: 592  SSHQISALVLRAQASEILLEELQQGLSQAKRDVQ---EQMAVLMQSREQVSEELVRLQKD 648
               ++    L  Q    L++ L+    Q+  D +   E +A L + +E++ +E   LQ  
Sbjct: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2499

Query: 649  NDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILF 708
            ++ +Q       ++QQ +   L   T+AL++  L  ++ ++      +  +EK K E LF
Sbjct: 2500 SEEMQ-------TVQQEQ---LLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLF 2547

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQ 768
              E  +A+Q  +E   +  Q+E E  +        L A +E  +  + + E  +R K ++
Sbjct: 2548 QDEVAKAQQLREEQQRQQQQMEQERQR--------LVASMEEARRRQHEAEEGVRRKQEE 2599

Query: 769  LESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 828
            L+ L       E+Q +++       E+L+ EE    QRL+ +L + E+  R    L+ + 
Sbjct: 2600 LQQL-------EQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHR--AALAHSE 2640

Query: 829  QVQLERIRQADSLERIRAILN 849
            +V   ++    +L   R  L+
Sbjct: 2641 EVTASQVAATKTLPNGRDALD 2661



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 170/827 (20%), Positives = 317/827 (38%), Gaps = 134/827 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1984 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 2037

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 2038 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2095

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2155

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2156 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2206

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2207 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2252

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2313 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2349

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2350 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2391

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2392 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2440

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2441 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2497

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2498 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2557

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2558 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2610

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQL 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     + 
Sbjct: 2611 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2667

Query: 759  E-----STLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEE 800
            E       LR K    + LQE  I   E+L++      TV++L   E
Sbjct: 2668 EPEHSFDGLRRK-VSAQRLQEAGILSAEELQRLAQGHTTVDELARRE 2713



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 174/828 (21%), Positives = 336/828 (40%), Gaps = 96/828 (11%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1055 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1110

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1111 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1170

Query: 193  KEIAALKDKLTEAE---DKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A+   +++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1171 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1226

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++       L   R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1227 RELEQLGRQ-------LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1279

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1280 -ALLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1334

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1335 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1390

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETAS 488
            +    L++     L  A + ++         LQ      + + +E A+ A   ++     
Sbjct: 1391 EVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ-QQKRSIQE 1447

Query: 489  LLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI 548
             L  + Q  E+   + +     +E     +++E+     +L          E +LQ ++ 
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1507

Query: 549  Q----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL----V 600
            +    EA+ R   ++ + + RQ  D+ ++  + + EL   +K  +E +  +  AL     
Sbjct: 1508 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1567

Query: 601  LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHS-LH 659
            LR QA     EE ++ L QA+ +   Q+ V +++ ++ +E    LQ    S   K + L 
Sbjct: 1568 LRLQA-----EEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASFAEKTAQLE 1620

Query: 660  VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEIL----FLKEQIQA 715
             SLQ+    +       LRE   +  +       A +  E +L+   L     L+ ++QA
Sbjct: 1621 RSLQEEHVAV-----AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQL-ESLQE 774
            E+  ++  +   Q E E  KEE    +  + + E   V + +L     EK +QL E   +
Sbjct: 1676 EEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733

Query: 775  IKISLEEQ---LKKETAAKATVEQLMFEEKNKAQR------------------LQTELDV 813
             +++ E++   L+ ET       QL+ EE  + QR                  ++ E++V
Sbjct: 1734 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1793

Query: 814  --------SEQVQRDFVKLSQTLQVQLERIRQ-ADSLERIRAILNDTK 852
                     E+ +    K  Q L+ +  R R+ A+   R+RA+  + K
Sbjct: 1794 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 86/463 (18%), Positives = 186/463 (40%), Gaps = 97/463 (20%)

Query: 450  ENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL 509
            E  +T ++  L++P    L K+  R       EQ++  + +  + +G+          RL
Sbjct: 1024 EACETRTVHRLRLP----LDKEPARECAQRIAEQQKAQAEVEGLGKGVA---------RL 1070

Query: 510  VSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQAND 569
             +E E  L   E   A   L    ++     +Q++ +    A   +++K + L++R    
Sbjct: 1071 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS---AIYLEKLKTISLVIRGTQG 1127

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
              E     +++L++         +  + A +   +A++  L++L+   ++A++   + + 
Sbjct: 1128 AEEVLRAHEEQLKE---------AQAVPATLPELEATKASLKKLR-AQAEAQQPTFDALR 1177

Query: 630  VLMQSREQVSEELVRLQKDND-SLQGKHSLHVSLQQAEDFILPDTTEALREL------VL 682
              ++  ++V E L +   + D  ++        L +    +L  T    REL      + 
Sbjct: 1178 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1237

Query: 683  KYRED-------IINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENC- 734
             YRE        + + R   + ++    A+   ++EQ++ EQ L E +E   + ++E C 
Sbjct: 1238 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQ 1296

Query: 735  ----------KEEIASISSLKAELERI-------KVEKGQ-------------------- 757
                      K+    + + KA+LE +       KV+ G                     
Sbjct: 1297 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1356

Query: 758  -------LESTLR-----------EKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
                   +  TLR           +++++ E L E++ +LE+Q +   A      Q   E
Sbjct: 1357 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1416

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 842
             K   QR+Q E+   E+   D  +  +++Q +L+++RQ+   E
Sbjct: 1417 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1459


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  109 bits (272), Expect = 1e-23
 Identities = 186/874 (21%), Positives = 368/874 (42%), Gaps = 125/874 (14%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQE--FNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            QQ  AE +K+  + L  ++QLE+E    QK    K    AK + L+ +  V+    + L 
Sbjct: 939  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 73   HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQF 132
              R  L E  +++    A     E  K + + ++K +    ++ L+  +K+     E + 
Sbjct: 999  KERKLLEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKK-----EEKS 1049

Query: 133  HLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
               LE+ + +          +IADL+ +++E      L+ ++ K +E+   L++ +  ++
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAE------LKMQLAKKEEE---LQAALARLD 1100

Query: 193  KEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDA 252
             EIA   + L     KI+ELE   + +L   L++E++ R   E        QK  L E+ 
Sbjct: 1101 DEIAQKNNAL----KKIRELE-GHISDLQEDLDSERAARNKAE-------KQKRDLGEEL 1148

Query: 253  EKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
            E L+ EL +       +QE R +  Q     +KA D+   S    +++M++       E 
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208

Query: 310  LRQVEELKK-KDQEDDEQQRLNKRK-----------------DHKKADVEEEIKIPVVCA 351
              Q+E+ K+ K   D  +Q L K                   +HKK  +E +++      
Sbjct: 1209 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1268

Query: 352  LTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQS 407
               E + A+L+++    +  ++S  G ++  +   +  + D  S S        L + ++
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328

Query: 408  TDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFM 467
               L  S  L+      N        LDE     +    ++  +  T    ++Q+     
Sbjct: 1329 RQKLNVSTKLRQLEEERN---SLQDQLDEE----MEAKQNLERHISTL---NIQLSDSKK 1378

Query: 468  LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
              +D    ++A+   ++     + ++TQ  E      + Y  + +T+ N LQ+E+ +   
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTK-NRLQQELDDLVV 1434

Query: 528  KLGRRCDMCSNYEKQLQGI------------------QIQEAETRDQVKKLQLMLR---- 565
             L  +  + SN EK+ +                       EAE R++  K   + R    
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494

Query: 566  --QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKR 622
              +A ++LE+T K  K E+ED +  S +D    +  L    +A E  +EE++  L + + 
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLV-SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553

Query: 623  DVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVL 682
            ++Q              +  +RL+ +  +L+G+    +   QA D    +    L+  + 
Sbjct: 1554 ELQ-----------ATEDAKLRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH 1599

Query: 683  KYR---EDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIA 739
            +Y    ED    R  A   ++KL+ ++  L  ++QA+  +K   E   QL     ++  A
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQL-----RKLQA 1652

Query: 740  SISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
             +   + ELE  +  + ++ +T +E  ++ +SL+   + L+E L    AA+   +Q   E
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL---AAAERARKQADLE 1709

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLE 833
            ++  A+ L + L     +Q +  +L   +  QLE
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARI-AQLE 1742



 Score =  102 bits (255), Expect = 1e-21
 Identities = 196/884 (22%), Positives = 395/884 (44%), Gaps = 90/884 (10%)

Query: 14   LQQRVAELE----KINAEFLRAQQQLEQEFNQKRAKFKELYLAK------EEDLKRQNAV 63
            LQ ++AEL+    K   E   A  +L+ E  QK    K++   +      +EDL  + A 
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133

Query: 64   LQAAQD---DLGH----LRTQL---WEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE 113
               A+    DLG     L+T+L    ++ A  + ++A         ++A+DE  R    +
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSE-GQEEENLEN 172
            V  ++    + V +   Q   + ++ +    + +++ E+E ADL   L   GQ ++ +E+
Sbjct: 1194 VQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252

Query: 173  EMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRT 232
            + KK +   ++L+S     E+  A L DK+ + +++++ +       LN   EAE     
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM----LN---EAEGKA-I 1304

Query: 233  DLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQR 292
             L   VA L++Q   LQ+  E L++E  +  ++  + RQ   + +++ Q   D+ +E+++
Sbjct: 1305 KLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQ 1360

Query: 293  LLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCAL 352
             L R +  + I L+  + +  +     +  ++ ++R  K  ++     EE+         
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAG------LLLPSGDPFSK-SDNDMFKDGLRRA 405
            T+     +L +    LD+ R  V +L+        LL    +  SK +D     +   R 
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 406  QSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA-DSVSENFDTASLGSLQMPS 464
            + T +L  + +L+ +AL    + +    + +++   LV + D V +N          + +
Sbjct: 1481 KETKALSLARALE-EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 465  GFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR-LVSETEWNLLQKEVH 523
                 K Q   ++      E+    L    Q ++  +      R   +E +   LQ+++H
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599

Query: 524  NAGNKLG---RRCDMCSNYEKQLQG-IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQ 579
                +L    ++  + +  +K+L+G ++  E +    +K  +  ++Q   +L+  MKD Q
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKDFQ 1658

Query: 580  -ELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQV 638
             ELED  + S ++          +A++ E  L +LQ+ L+ A+R    + A L   +E++
Sbjct: 1659 RELED-ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER--ARKQADL--EKEEL 1713

Query: 639  SEELVRLQKDNDSLQG-KHSLHVSLQQAEDFILPD--TTEALRELVLKYREDIINVRTAA 695
            +EEL       ++LQ  K  L   + Q E+ +  +    EA+ + V K  +        A
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ-------A 1766

Query: 696  DHVEEKLKAEILFLKEQIQAEQCL-KENLEETLQL-EIENC-----KEEIASISSLKAEL 748
            + +  +L  E    ++   A Q L ++N E   +L E+E       K  IA++ +  A+L
Sbjct: 1767 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826

Query: 749  E-RIKVEKGQLESTLREKSQQLESLQEIKISLEEQLK-----KETAAK--ATVEQL---M 797
            E +++ E  + ++  +   Q+ + L+EI + +E++ K     KE A K  A V+QL   +
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886

Query: 798  FEEKNKAQR-------LQTELDVSEQVQRDFVKLSQTLQVQLER 834
             E + ++QR       LQ ELD + +      +    L+ +L R
Sbjct: 1887 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930



 Score =  100 bits (249), Expect = 6e-21
 Identities = 172/820 (20%), Positives = 338/820 (41%), Gaps = 126/820 (15%)

Query: 59   RQNAVLQAAQDDLGHLRTQLWEAQAEMENIK---AIATVSENTKQEAIDEVKRQWRE--E 113
            RQ   +QA +D+L   + +  +A+ E++ ++   +  T  +N  QE +      + E  E
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQY---RESAEREIADLRRRLSEGQE-EEN 169
            +    A  K+ + +  H+   RLE+E  +  Q    R+   +++ DL  +L E +   + 
Sbjct: 909  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968

Query: 170  LENEMKKAQEDAEKLRSVVMPM--------------EKEIAALKDKLTEAEDKIKEL--- 212
            L+ E   A+   +KL   ++ M              E+ I+ L   L E E+K K L   
Sbjct: 969  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1028

Query: 213  ---EASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE 269
                 S + EL   L+ E+  R +LE     L    S   E    L+ ++ E   L  Q 
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQL 1085

Query: 270  RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRL 329
             ++  +L+    + +D+  +    L             +++R++E      QED + +R 
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNAL-------------KKIRELEGHISDLQEDLDSERA 1132

Query: 330  NKRKDHK-KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
             + K  K K D+ EE++       T+ E +   +  ++ L + R      +  +L  + D
Sbjct: 1133 ARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALD 1184

Query: 389  PFSKSDNDMFKD-GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADS 447
              ++S     ++   + AQ+ + L       ++ L    +AK+  NLD++          
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEEL-------TEQLEQFKRAKA--NLDKNK------QTL 1229

Query: 448  VSENFDTAS----LGSLQMPSGFMLTK--DQERAIKAMTPEQEETASLLSSVTQGMESAY 501
              EN D A     LG  +        K   Q + +++   + E   + L+     +++  
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289

Query: 502  VSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQ 561
             S +G    +E +   L K+V +  ++L        + ++ LQ    Q+     ++++L+
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQL-------QDTQELLQEETRQKLNVSTKLRQLE 1342

Query: 562  LMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQ---QGLS 618
                   DQL++ M+ KQ LE             IS L ++   S+  L++     + L 
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLE-----------RHISTLNIQLSDSKKKLQDFASTVEALE 1391

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALR 678
            + K+  Q+++  L Q  E+ +    +L+K  + LQ         Q+ +D ++        
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ---------QELDDLVV-------- 1434

Query: 679  ELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEI 738
                    D+ N R    ++E+K +     L E+   +    +  +E  + E E  ++E 
Sbjct: 1435 --------DLDNQRQLVSNLEKKQRKFDQLLAEE---KNISSKYADERDRAEAEAREKET 1483

Query: 739  ASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMF 798
             ++S  +A LE     K +LE T +    ++E L   K  + + + +   +K  +E  M 
Sbjct: 1484 KALSLARA-LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 799  EEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQA 838
            E K + + L+ EL  +E  +       Q L+ Q ER  QA
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582



 Score =  100 bits (249), Expect = 6e-21
 Identities = 199/968 (20%), Positives = 383/968 (39%), Gaps = 192/968 (19%)

Query: 19   AELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH----L 74
            AE E++       +Q+LE+  ++  A+ +E     EED  +Q   LQA +  +      L
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEMEARLEE-----EEDRGQQ---LQAERKKMAQQMLDL 955

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDE--VKRQWREEVASLQAVMKETVRDYEHQF 132
              QL E +A  + ++     +E   ++  DE  V      +++  + +++E + D     
Sbjct: 956  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT-- 1013

Query: 133  HLRLEQERTQ-WAQYRESAEREIADLRRRLS-EGQEEENLENEMKKAQEDAEKLRSVVMP 190
            +L  E+E+ +   + +   E  I++L  RL  E +  + LE   +K + DA      +  
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 191  MEKEIAALKDKLTEAED---------------------KIKELEASKVKELNHYLEAEKS 229
            ++ +IA LK +L + E+                     KI+ELE   + +L   L++E++
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH-ISDLQEDLDSERA 1132

Query: 230  CRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQ 286
             R   E        QK  L E+ E L+ EL +       +QE R +  Q     +KA D+
Sbjct: 1133 ARNKAEK-------QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 287  FLESQRLLMRDMQRMEIVLTSEQLRQVEELKK-KDQEDDEQQRLNKRK------------ 333
               S    +++M++       E   Q+E+ K+ K   D  +Q L K              
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245

Query: 334  -----DHKKADVEEEIKIPVVCALTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLL 384
                 +HKK  +E +++         E + A+L+++    +  ++S  G ++  +   + 
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305

Query: 385  PSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVG 444
             + D  S S        L + ++   L  S  L+      N        LDE     +  
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEE----MEA 1358

Query: 445  ADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSP 504
              ++  +  T ++   Q+       +D    ++A+   ++     + ++TQ  E      
Sbjct: 1359 KQNLERHISTLNI---QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KA 1412

Query: 505  SGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI---------------- 548
            + Y  + +T+ N LQ+E+ +    L  +  + SN EK+ +                    
Sbjct: 1413 AAYDKLEKTK-NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471

Query: 549  --QEAETRDQVKKLQLMLR------QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISAL 599
               EAE R++  K   + R      +A ++LE+T K  K E+ED +  S +D    +  L
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS-SKDDVGKNVHEL 1530

Query: 600  VLRAQASEILLEELQQGLS------QAKRDVQEQMAVLMQSR------------EQVSEE 641
                +A E  +EE++  L       QA  D + ++ V MQ+             EQ  E+
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590

Query: 642  LVRLQKDNDSLQ---------------GKHSLHVSLQQAE---DFILPDTTEALREL--- 680
              +LQ+     +                K  L   L+  E   D  +    EA+++L   
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650

Query: 681  ---VLKYREDIINVRTAADHV----------EEKLKAEILFLKEQIQAEQCLKENLEETL 727
               +  ++ ++ + R + D +           + L+A+++ L+E + A     E   +  
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA----ERARKQA 1706

Query: 728  QLEIENCKEEIAS------------------ISSLKAELERIKVEKGQLESTLREKSQQL 769
             LE E   EE+AS                  I+ L+ ELE  +     +   +R+ +QQ 
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766

Query: 770  ESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQ 829
            E L     S E   ++ TA K    +   E +NK  R +   ++   V+  F      L+
Sbjct: 1767 EQL-----SNELATERSTAQKNESARQQLERQNKELRSKLH-EMEGAVKSKFKSTIAALE 1820

Query: 830  VQLERIRQ 837
             ++ ++ +
Sbjct: 1821 AKIAQLEE 1828



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/700 (21%), Positives = 310/700 (44%), Gaps = 91/700 (13%)

Query: 192  EKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
            E E+   K++  +AE+++KELE   S++ E  + L+ +    T+L      +  + +  +
Sbjct: 858  EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLE-SQRLLMRDMQRMEIVLTSE 308
            ++ E++   LHE+   LE+E  +  QL+   +K   Q L+  ++L   +  R ++ L  E
Sbjct: 918  QELEEI---LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL--E 972

Query: 309  QLRQVEELKKKDQE----DDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ---- 360
            ++    ++KK + E    DD+  +L+K +      +EE I   +   L +EE  A+    
Sbjct: 973  KVTAEAKIKKLEDEILVMDDQNNKLSKERKL----LEERIS-DLTTNLAEEEEKAKNLTK 1027

Query: 361  LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420
            L N+ E +      +  L+  L     +  S+ + +  K  L    ++D       LQ++
Sbjct: 1028 LKNKHESM------ISELEVRL---KKEEKSRQELEKLKRKLE-GDASDFHEQIADLQAQ 1077

Query: 421  ALGYNYKAKSAGNLDESDFGPLVGADSVSE-NFDTASLGSLQMP-SGFMLTKDQERAIKA 478
                  K + A   +E         D +++ N     +  L+   S      D ERA + 
Sbjct: 1078 IA--ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135

Query: 479  MTPEQ-----EETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRC 533
               +Q     EE  +L + +   ++S   +    R   E E  +L+K +           
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDST-ATQQELRAKREQEVTVLKKALD---------- 1184

Query: 534  DMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSS 593
            +   ++E Q+Q ++ + A+  +++ +     ++A   L+K   +KQ LE       ++++
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLE-------KENA 1234

Query: 594  HQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQ 653
                 L +  QA + + E  ++ L    +++Q + +   ++R ++++++ +LQ + +S+ 
Sbjct: 1235 DLAGELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293

Query: 654  G--KHSLHVSLQQAEDFI-LPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
            G    +   +++ A+D   L    +  +EL+ +     +NV T    +EE+  +    L+
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS----LQ 1349

Query: 711  EQIQAEQCLKENLEE---TLQLEIENCKEEIASISSLKAELE----RIKVEKGQLESTLR 763
            +Q+  E   K+NLE    TL +++ + K+++   +S    LE    R + E   L     
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 764  EKSQQLESLQEIKISLEEQLKKETA--------------AKATVEQLMFEEKNKAQRLQT 809
            EK+   + L++ K  L+++L                    +   +QL+ EEKN + +   
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 810  ELDVSEQVQRDFVKLSQTLQVQLERIRQA-DSLERIRAIL 848
            E D +E   R+    + +L   LE   +A + LER   +L
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 81/364 (22%), Positives = 149/364 (40%), Gaps = 69/364 (18%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAV---LQAAQDDL 71
            ++ + +L K+ A+    Q++LE      RA   E++   +E+ K+  ++   L   Q+DL
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDA----RASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
                    +A  E E + A    S  + + A+ + KR+    +A L+  ++E       Q
Sbjct: 1697 AAAERARKQADLEKEEL-AEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQ 1749

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPM 191
             ++    +R + A                    Q+ E L NE+   +  A+K  S    +
Sbjct: 1750 GNMEAMSDRVRKAT-------------------QQAEQLSNELATERSTAQKNESARQQL 1790

Query: 192  EKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQED 251
            E++   L+ KL E E  +K    SK K     LEA+ +    LE  V     +K    + 
Sbjct: 1791 ERQNKELRSKLHEMEGAVK----SKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKS 1843

Query: 252  AEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLR 311
             ++  K+L E+   +E ER+   Q K   +K N                           
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--------------------------A 1877

Query: 312  QVEELKKKDQE-DDEQQRLN--KRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHL 368
            +V++LK++ +E ++E QR+N  +RK  ++ D   E    +   +   +S  +  NE   +
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFV 1937

Query: 369  DSTR 372
             S R
Sbjct: 1938 PSRR 1941



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 61/298 (20%), Positives = 131/298 (43%), Gaps = 22/298 (7%)

Query: 556  QVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQ 615
            QV + +  ++   D+L+KT + +Q+ E+ +K+  +  S          +   +L E+LQ 
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQL-------TEEKNLLQEQLQA 898

Query: 616  G--LSQAKRDVQEQMAVLMQSREQVSEEL-VRLQKDNDSLQGKHSLHVSLQQAEDFILPD 672
               L     +++ ++A   Q  E++  E+  RL+++ D  Q   +    + Q     + D
Sbjct: 899  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ----MLD 954

Query: 673  TTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIE 732
              E L E     R+ +   +  A+   +KL+ EIL + +Q       ++ LEE +     
Sbjct: 955  LEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013

Query: 733  NCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE-------EQLKK 785
            N  EE     +L     + +    +LE  L+++ +  + L+++K  LE       EQ+  
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 786  ETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
              A  A ++  + +++ + Q     LD     + + +K  + L+  +  +++    ER
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 26/154 (16%)

Query: 719 LKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKIS 778
           +K  L+ T Q E    KE+         EL++ K  + + E+ L+E  Q+   L E K  
Sbjct: 841 VKPLLQVTRQEEEMQAKED---------ELQKTKERQQKAENELKELEQKHSQLTEEKNL 891

Query: 779 LEEQLKKETAAKATVEQLMFEEKNKAQ-----------RLQTELDVSEQVQRDFVKLSQ- 826
           L+EQL+ ET   A  E++      K Q           RL+ E D  +Q+Q +  K++Q 
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951

Query: 827 --TLQVQLER---IRQADSLERIRAILNDTKLTD 855
              L+ QLE     RQ   LE++ A     KL D
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 985



 Score = 37.7 bits (86), Expect = 0.046
 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 3/103 (2%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD-- 70
            +L+ ++A+LE+   +  R +Q   +   QK  K KE+ L  E++ K      + A+    
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877

Query: 71   -LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWRE 112
             +  L+ QL EA+ E + I A     +    EA +  +   RE
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  109 bits (272), Expect = 1e-23
 Identities = 186/874 (21%), Positives = 368/874 (42%), Gaps = 125/874 (14%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQE--FNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            QQ  AE +K+  + L  ++QLE+E    QK    K    AK + L+ +  V+    + L 
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 73   HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQF 132
              R  L E  +++    A     E  K + + ++K +    ++ L+  +K+     E + 
Sbjct: 1006 KERKLLEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKK-----EEKS 1056

Query: 133  HLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
               LE+ + +          +IADL+ +++E      L+ ++ K +E+   L++ +  ++
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAE------LKMQLAKKEEE---LQAALARLD 1107

Query: 193  KEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDA 252
             EIA   + L     KI+ELE   + +L   L++E++ R   E        QK  L E+ 
Sbjct: 1108 DEIAQKNNAL----KKIRELE-GHISDLQEDLDSERAARNKAE-------KQKRDLGEEL 1155

Query: 253  EKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
            E L+ EL +       +QE R +  Q     +KA D+   S    +++M++       E 
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215

Query: 310  LRQVEELKK-KDQEDDEQQRLNKRK-----------------DHKKADVEEEIKIPVVCA 351
              Q+E+ K+ K   D  +Q L K                   +HKK  +E +++      
Sbjct: 1216 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1275

Query: 352  LTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQS 407
               E + A+L+++    +  ++S  G ++  +   +  + D  S S        L + ++
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335

Query: 408  TDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFM 467
               L  S  L+      N        LDE     +    ++  +  T    ++Q+     
Sbjct: 1336 RQKLNVSTKLRQLEEERN---SLQDQLDEE----MEAKQNLERHISTL---NIQLSDSKK 1385

Query: 468  LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
              +D    ++A+   ++     + ++TQ  E      + Y  + +T+ N LQ+E+ +   
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTK-NRLQQELDDLVV 1441

Query: 528  KLGRRCDMCSNYEKQLQGI------------------QIQEAETRDQVKKLQLMLR---- 565
             L  +  + SN EK+ +                       EAE R++  K   + R    
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501

Query: 566  --QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKR 622
              +A ++LE+T K  K E+ED +  S +D    +  L    +A E  +EE++  L + + 
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLV-SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560

Query: 623  DVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVL 682
            ++Q              +  +RL+ +  +L+G+    +   QA D    +    L+  + 
Sbjct: 1561 ELQ-----------ATEDAKLRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH 1606

Query: 683  KYR---EDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIA 739
            +Y    ED    R  A   ++KL+ ++  L  ++QA+  +K   E   QL     ++  A
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQL-----RKLQA 1659

Query: 740  SISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
             +   + ELE  +  + ++ +T +E  ++ +SL+   + L+E L    AA+   +Q   E
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL---AAAERARKQADLE 1716

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLE 833
            ++  A+ L + L     +Q +  +L   +  QLE
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARI-AQLE 1749



 Score =  102 bits (255), Expect = 1e-21
 Identities = 196/884 (22%), Positives = 395/884 (44%), Gaps = 90/884 (10%)

Query: 14   LQQRVAELE----KINAEFLRAQQQLEQEFNQKRAKFKELYLAK------EEDLKRQNAV 63
            LQ ++AEL+    K   E   A  +L+ E  QK    K++   +      +EDL  + A 
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140

Query: 64   LQAAQD---DLGH----LRTQL---WEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE 113
               A+    DLG     L+T+L    ++ A  + ++A         ++A+DE  R    +
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSE-GQEEENLEN 172
            V  ++    + V +   Q   + ++ +    + +++ E+E ADL   L   GQ ++ +E+
Sbjct: 1201 VQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 173  EMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRT 232
            + KK +   ++L+S     E+  A L DK+ + +++++ +       LN   EAE     
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM----LN---EAEGKA-I 1311

Query: 233  DLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQR 292
             L   VA L++Q   LQ+  E L++E  +  ++  + RQ   + +++ Q   D+ +E+++
Sbjct: 1312 KLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQ 1367

Query: 293  LLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCAL 352
             L R +  + I L+  + +  +     +  ++ ++R  K  ++     EE+         
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAG------LLLPSGDPFSK-SDNDMFKDGLRRA 405
            T+     +L +    LD+ R  V +L+        LL    +  SK +D     +   R 
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 406  QSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA-DSVSENFDTASLGSLQMPS 464
            + T +L  + +L+ +AL    + +    + +++   LV + D V +N          + +
Sbjct: 1488 KETKALSLARALE-EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 465  GFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR-LVSETEWNLLQKEVH 523
                 K Q   ++      E+    L    Q ++  +      R   +E +   LQ+++H
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 524  NAGNKLG---RRCDMCSNYEKQLQG-IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQ 579
                +L    ++  + +  +K+L+G ++  E +    +K  +  ++Q   +L+  MKD Q
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKDFQ 1665

Query: 580  -ELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQV 638
             ELED  + S ++          +A++ E  L +LQ+ L+ A+R    + A L   +E++
Sbjct: 1666 RELED-ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER--ARKQADL--EKEEL 1720

Query: 639  SEELVRLQKDNDSLQG-KHSLHVSLQQAEDFILPD--TTEALRELVLKYREDIINVRTAA 695
            +EEL       ++LQ  K  L   + Q E+ +  +    EA+ + V K  +        A
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ-------A 1773

Query: 696  DHVEEKLKAEILFLKEQIQAEQCL-KENLEETLQL-EIENC-----KEEIASISSLKAEL 748
            + +  +L  E    ++   A Q L ++N E   +L E+E       K  IA++ +  A+L
Sbjct: 1774 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833

Query: 749  E-RIKVEKGQLESTLREKSQQLESLQEIKISLEEQLK-----KETAAK--ATVEQL---M 797
            E +++ E  + ++  +   Q+ + L+EI + +E++ K     KE A K  A V+QL   +
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893

Query: 798  FEEKNKAQR-------LQTELDVSEQVQRDFVKLSQTLQVQLER 834
             E + ++QR       LQ ELD + +      +    L+ +L R
Sbjct: 1894 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937



 Score =  100 bits (249), Expect = 6e-21
 Identities = 172/820 (20%), Positives = 338/820 (41%), Gaps = 126/820 (15%)

Query: 59   RQNAVLQAAQDDLGHLRTQLWEAQAEMENIK---AIATVSENTKQEAIDEVKRQWRE--E 113
            RQ   +QA +D+L   + +  +A+ E++ ++   +  T  +N  QE +      + E  E
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQY---RESAEREIADLRRRLSEGQE-EEN 169
            +    A  K+ + +  H+   RLE+E  +  Q    R+   +++ DL  +L E +   + 
Sbjct: 916  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

Query: 170  LENEMKKAQEDAEKLRSVVMPM--------------EKEIAALKDKLTEAEDKIKEL--- 212
            L+ E   A+   +KL   ++ M              E+ I+ L   L E E+K K L   
Sbjct: 976  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1035

Query: 213  ---EASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE 269
                 S + EL   L+ E+  R +LE     L    S   E    L+ ++ E   L  Q 
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQL 1092

Query: 270  RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRL 329
             ++  +L+    + +D+  +    L             +++R++E      QED + +R 
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNAL-------------KKIRELEGHISDLQEDLDSERA 1139

Query: 330  NKRKDHK-KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
             + K  K K D+ EE++       T+ E +   +  ++ L + R      +  +L  + D
Sbjct: 1140 ARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALD 1191

Query: 389  PFSKSDNDMFKD-GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADS 447
              ++S     ++   + AQ+ + L       ++ L    +AK+  NLD++          
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEEL-------TEQLEQFKRAKA--NLDKNK------QTL 1236

Query: 448  VSENFDTAS----LGSLQMPSGFMLTK--DQERAIKAMTPEQEETASLLSSVTQGMESAY 501
              EN D A     LG  +        K   Q + +++   + E   + L+     +++  
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296

Query: 502  VSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQ 561
             S +G    +E +   L K+V +  ++L        + ++ LQ    Q+     ++++L+
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQL-------QDTQELLQEETRQKLNVSTKLRQLE 1349

Query: 562  LMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQ---QGLS 618
                   DQL++ M+ KQ LE             IS L ++   S+  L++     + L 
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLE-----------RHISTLNIQLSDSKKKLQDFASTVEALE 1398

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALR 678
            + K+  Q+++  L Q  E+ +    +L+K  + LQ         Q+ +D ++        
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ---------QELDDLVV-------- 1441

Query: 679  ELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEI 738
                    D+ N R    ++E+K +     L E+   +    +  +E  + E E  ++E 
Sbjct: 1442 --------DLDNQRQLVSNLEKKQRKFDQLLAEE---KNISSKYADERDRAEAEAREKET 1490

Query: 739  ASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMF 798
             ++S  +A LE     K +LE T +    ++E L   K  + + + +   +K  +E  M 
Sbjct: 1491 KALSLARA-LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 799  EEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQA 838
            E K + + L+ EL  +E  +       Q L+ Q ER  QA
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589



 Score =  100 bits (249), Expect = 6e-21
 Identities = 199/968 (20%), Positives = 383/968 (39%), Gaps = 192/968 (19%)

Query: 19   AELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH----L 74
            AE E++       +Q+LE+  ++  A+ +E     EED  +Q   LQA +  +      L
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEMEARLEE-----EEDRGQQ---LQAERKKMAQQMLDL 962

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDE--VKRQWREEVASLQAVMKETVRDYEHQF 132
              QL E +A  + ++     +E   ++  DE  V      +++  + +++E + D     
Sbjct: 963  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT-- 1020

Query: 133  HLRLEQERTQ-WAQYRESAEREIADLRRRLS-EGQEEENLENEMKKAQEDAEKLRSVVMP 190
            +L  E+E+ +   + +   E  I++L  RL  E +  + LE   +K + DA      +  
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 191  MEKEIAALKDKLTEAED---------------------KIKELEASKVKELNHYLEAEKS 229
            ++ +IA LK +L + E+                     KI+ELE   + +L   L++E++
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH-ISDLQEDLDSERA 1139

Query: 230  CRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQ 286
             R   E        QK  L E+ E L+ EL +       +QE R +  Q     +KA D+
Sbjct: 1140 ARNKAEK-------QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 287  FLESQRLLMRDMQRMEIVLTSEQLRQVEELKK-KDQEDDEQQRLNKRK------------ 333
               S    +++M++       E   Q+E+ K+ K   D  +Q L K              
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252

Query: 334  -----DHKKADVEEEIKIPVVCALTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLL 384
                 +HKK  +E +++         E + A+L+++    +  ++S  G ++  +   + 
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312

Query: 385  PSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVG 444
             + D  S S        L + ++   L  S  L+      N        LDE     +  
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEE----MEA 1365

Query: 445  ADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSP 504
              ++  +  T ++   Q+       +D    ++A+   ++     + ++TQ  E      
Sbjct: 1366 KQNLERHISTLNI---QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KA 1419

Query: 505  SGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI---------------- 548
            + Y  + +T+ N LQ+E+ +    L  +  + SN EK+ +                    
Sbjct: 1420 AAYDKLEKTK-NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478

Query: 549  --QEAETRDQVKKLQLMLR------QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISAL 599
               EAE R++  K   + R      +A ++LE+T K  K E+ED +  S +D    +  L
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS-SKDDVGKNVHEL 1537

Query: 600  VLRAQASEILLEELQQGLS------QAKRDVQEQMAVLMQSR------------EQVSEE 641
                +A E  +EE++  L       QA  D + ++ V MQ+             EQ  E+
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597

Query: 642  LVRLQKDNDSLQ---------------GKHSLHVSLQQAE---DFILPDTTEALREL--- 680
              +LQ+     +                K  L   L+  E   D  +    EA+++L   
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657

Query: 681  ---VLKYREDIINVRTAADHV----------EEKLKAEILFLKEQIQAEQCLKENLEETL 727
               +  ++ ++ + R + D +           + L+A+++ L+E + A     E   +  
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA----ERARKQA 1713

Query: 728  QLEIENCKEEIAS------------------ISSLKAELERIKVEKGQLESTLREKSQQL 769
             LE E   EE+AS                  I+ L+ ELE  +     +   +R+ +QQ 
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773

Query: 770  ESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQ 829
            E L     S E   ++ TA K    +   E +NK  R +   ++   V+  F      L+
Sbjct: 1774 EQL-----SNELATERSTAQKNESARQQLERQNKELRSKLH-EMEGAVKSKFKSTIAALE 1827

Query: 830  VQLERIRQ 837
             ++ ++ +
Sbjct: 1828 AKIAQLEE 1835



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/700 (21%), Positives = 310/700 (44%), Gaps = 91/700 (13%)

Query: 192  EKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
            E E+   K++  +AE+++KELE   S++ E  + L+ +    T+L      +  + +  +
Sbjct: 865  EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLE-SQRLLMRDMQRMEIVLTSE 308
            ++ E++   LHE+   LE+E  +  QL+   +K   Q L+  ++L   +  R ++ L  E
Sbjct: 925  QELEEI---LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL--E 979

Query: 309  QLRQVEELKKKDQE----DDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ---- 360
            ++    ++KK + E    DD+  +L+K +      +EE I   +   L +EE  A+    
Sbjct: 980  KVTAEAKIKKLEDEILVMDDQNNKLSKERKL----LEERIS-DLTTNLAEEEEKAKNLTK 1034

Query: 361  LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420
            L N+ E +      +  L+  L     +  S+ + +  K  L    ++D       LQ++
Sbjct: 1035 LKNKHESM------ISELEVRL---KKEEKSRQELEKLKRKLE-GDASDFHEQIADLQAQ 1084

Query: 421  ALGYNYKAKSAGNLDESDFGPLVGADSVSE-NFDTASLGSLQMP-SGFMLTKDQERAIKA 478
                  K + A   +E         D +++ N     +  L+   S      D ERA + 
Sbjct: 1085 IA--ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142

Query: 479  MTPEQ-----EETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRC 533
               +Q     EE  +L + +   ++S   +    R   E E  +L+K +           
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDST-ATQQELRAKREQEVTVLKKALD---------- 1191

Query: 534  DMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSS 593
            +   ++E Q+Q ++ + A+  +++ +     ++A   L+K   +KQ LE       ++++
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLE-------KENA 1241

Query: 594  HQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQ 653
                 L +  QA + + E  ++ L    +++Q + +   ++R ++++++ +LQ + +S+ 
Sbjct: 1242 DLAGELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300

Query: 654  G--KHSLHVSLQQAEDFI-LPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
            G    +   +++ A+D   L    +  +EL+ +     +NV T    +EE+  +    L+
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS----LQ 1356

Query: 711  EQIQAEQCLKENLEE---TLQLEIENCKEEIASISSLKAELE----RIKVEKGQLESTLR 763
            +Q+  E   K+NLE    TL +++ + K+++   +S    LE    R + E   L     
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 764  EKSQQLESLQEIKISLEEQLKKETA--------------AKATVEQLMFEEKNKAQRLQT 809
            EK+   + L++ K  L+++L                    +   +QL+ EEKN + +   
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 810  ELDVSEQVQRDFVKLSQTLQVQLERIRQA-DSLERIRAIL 848
            E D +E   R+    + +L   LE   +A + LER   +L
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 81/364 (22%), Positives = 149/364 (40%), Gaps = 69/364 (18%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAV---LQAAQDDL 71
            ++ + +L K+ A+    Q++LE      RA   E++   +E+ K+  ++   L   Q+DL
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDA----RASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
                    +A  E E + A    S  + + A+ + KR+    +A L+  ++E       Q
Sbjct: 1704 AAAERARKQADLEKEEL-AEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQ 1756

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPM 191
             ++    +R + A                    Q+ E L NE+   +  A+K  S    +
Sbjct: 1757 GNMEAMSDRVRKAT-------------------QQAEQLSNELATERSTAQKNESARQQL 1797

Query: 192  EKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQED 251
            E++   L+ KL E E  +K    SK K     LEA+ +    LE  V     +K    + 
Sbjct: 1798 ERQNKELRSKLHEMEGAVK----SKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKS 1850

Query: 252  AEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLR 311
             ++  K+L E+   +E ER+   Q K   +K N                           
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--------------------------A 1884

Query: 312  QVEELKKKDQE-DDEQQRLN--KRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHL 368
            +V++LK++ +E ++E QR+N  +RK  ++ D   E    +   +   +S  +  NE   +
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFV 1944

Query: 369  DSTR 372
             S R
Sbjct: 1945 PSRR 1948



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 61/298 (20%), Positives = 131/298 (43%), Gaps = 22/298 (7%)

Query: 556  QVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQ 615
            QV + +  ++   D+L+KT + +Q+ E+ +K+  +  S          +   +L E+LQ 
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQL-------TEEKNLLQEQLQA 905

Query: 616  G--LSQAKRDVQEQMAVLMQSREQVSEEL-VRLQKDNDSLQGKHSLHVSLQQAEDFILPD 672
               L     +++ ++A   Q  E++  E+  RL+++ D  Q   +    + Q     + D
Sbjct: 906  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ----MLD 961

Query: 673  TTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIE 732
              E L E     R+ +   +  A+   +KL+ EIL + +Q       ++ LEE +     
Sbjct: 962  LEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020

Query: 733  NCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE-------EQLKK 785
            N  EE     +L     + +    +LE  L+++ +  + L+++K  LE       EQ+  
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 786  ETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
              A  A ++  + +++ + Q     LD     + + +K  + L+  +  +++    ER
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 26/154 (16%)

Query: 719 LKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKIS 778
           +K  L+ T Q E    KE+         EL++ K  + + E+ L+E  Q+   L E K  
Sbjct: 848 VKPLLQVTRQEEEMQAKED---------ELQKTKERQQKAENELKELEQKHSQLTEEKNL 898

Query: 779 LEEQLKKETAAKATVEQLMFEEKNKAQ-----------RLQTELDVSEQVQRDFVKLSQ- 826
           L+EQL+ ET   A  E++      K Q           RL+ E D  +Q+Q +  K++Q 
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958

Query: 827 --TLQVQLER---IRQADSLERIRAILNDTKLTD 855
              L+ QLE     RQ   LE++ A     KL D
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 992



 Score = 37.7 bits (86), Expect = 0.046
 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 3/103 (2%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD-- 70
            +L+ ++A+LE+   +  R +Q   +   QK  K KE+ L  E++ K      + A+    
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884

Query: 71   -LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWRE 112
             +  L+ QL EA+ E + I A     +    EA +  +   RE
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  109 bits (272), Expect = 1e-23
 Identities = 186/874 (21%), Positives = 368/874 (42%), Gaps = 125/874 (14%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQE--FNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            QQ  AE +K+  + L  ++QLE+E    QK    K    AK + L+ +  V+    + L 
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 73   HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQF 132
              R  L E  +++    A     E  K + + ++K +    ++ L+  +K+     E + 
Sbjct: 1006 KERKLLEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKK-----EEKS 1056

Query: 133  HLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
               LE+ + +          +IADL+ +++E      L+ ++ K +E+   L++ +  ++
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAE------LKMQLAKKEEE---LQAALARLD 1107

Query: 193  KEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDA 252
             EIA   + L     KI+ELE   + +L   L++E++ R   E        QK  L E+ 
Sbjct: 1108 DEIAQKNNAL----KKIRELE-GHISDLQEDLDSERAARNKAE-------KQKRDLGEEL 1155

Query: 253  EKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
            E L+ EL +       +QE R +  Q     +KA D+   S    +++M++       E 
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215

Query: 310  LRQVEELKK-KDQEDDEQQRLNKRK-----------------DHKKADVEEEIKIPVVCA 351
              Q+E+ K+ K   D  +Q L K                   +HKK  +E +++      
Sbjct: 1216 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1275

Query: 352  LTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQS 407
               E + A+L+++    +  ++S  G ++  +   +  + D  S S        L + ++
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335

Query: 408  TDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFM 467
               L  S  L+      N        LDE     +    ++  +  T    ++Q+     
Sbjct: 1336 RQKLNVSTKLRQLEEERN---SLQDQLDEE----MEAKQNLERHISTL---NIQLSDSKK 1385

Query: 468  LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
              +D    ++A+   ++     + ++TQ  E      + Y  + +T+ N LQ+E+ +   
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTK-NRLQQELDDLVV 1441

Query: 528  KLGRRCDMCSNYEKQLQGI------------------QIQEAETRDQVKKLQLMLR---- 565
             L  +  + SN EK+ +                       EAE R++  K   + R    
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501

Query: 566  --QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKR 622
              +A ++LE+T K  K E+ED +  S +D    +  L    +A E  +EE++  L + + 
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLV-SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560

Query: 623  DVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVL 682
            ++Q              +  +RL+ +  +L+G+    +   QA D    +    L+  + 
Sbjct: 1561 ELQ-----------ATEDAKLRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH 1606

Query: 683  KYR---EDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIA 739
            +Y    ED    R  A   ++KL+ ++  L  ++QA+  +K   E   QL     ++  A
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQL-----RKLQA 1659

Query: 740  SISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
             +   + ELE  +  + ++ +T +E  ++ +SL+   + L+E L    AA+   +Q   E
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL---AAAERARKQADLE 1716

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLE 833
            ++  A+ L + L     +Q +  +L   +  QLE
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARI-AQLE 1749



 Score =  101 bits (252), Expect = 3e-21
 Identities = 193/862 (22%), Positives = 387/862 (44%), Gaps = 90/862 (10%)

Query: 14   LQQRVAELE----KINAEFLRAQQQLEQEFNQKRAKFKELYLAK------EEDLKRQNAV 63
            LQ ++AEL+    K   E   A  +L+ E  QK    K++   +      +EDL  + A 
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140

Query: 64   LQAAQD---DLGH----LRTQL---WEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE 113
               A+    DLG     L+T+L    ++ A  + ++A         ++A+DE  R    +
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSE-GQEEENLEN 172
            V  ++    + V +   Q   + ++ +    + +++ E+E ADL   L   GQ ++ +E+
Sbjct: 1201 VQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 173  EMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRT 232
            + KK +   ++L+S     E+  A L DK+ + +++++ +       LN   EAE     
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM----LN---EAEGKA-I 1311

Query: 233  DLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQR 292
             L   VA L++Q   LQ+  E L++E  +  ++  + RQ   + +++ Q   D+ +E+++
Sbjct: 1312 KLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQ 1367

Query: 293  LLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCAL 352
             L R +  + I L+  + +  +     +  ++ ++R  K  ++     EE+         
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAG------LLLPSGDPFSK-SDNDMFKDGLRRA 405
            T+     +L +    LD+ R  V +L+        LL    +  SK +D     +   R 
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 406  QSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA-DSVSENFDTASLGSLQMPS 464
            + T +L  + +L+ +AL    + +    + +++   LV + D V +N          + +
Sbjct: 1488 KETKALSLARALE-EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 465  GFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR-LVSETEWNLLQKEVH 523
                 K Q   ++      E+    L    Q ++  +      R   +E +   LQ+++H
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 524  NAGNKLG---RRCDMCSNYEKQLQG-IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQ 579
                +L    ++  + +  +K+L+G ++  E +    +K  +  ++Q   +L+  MKD Q
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKDFQ 1665

Query: 580  -ELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQV 638
             ELED  + S ++          +A++ E  L +LQ+ L+ A+R    + A L   +E++
Sbjct: 1666 RELED-ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER--ARKQADL--EKEEL 1720

Query: 639  SEELVRLQKDNDSLQG-KHSLHVSLQQAEDFILPD--TTEALRELVLKYREDIINVRTAA 695
            +EEL       ++LQ  K  L   + Q E+ +  +    EA+ + V K  +        A
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ-------A 1773

Query: 696  DHVEEKLKAEILFLKEQIQAEQCL-KENLEETLQL-EIENC-----KEEIASISSLKAEL 748
            + +  +L  E    ++   A Q L ++N E   +L E+E       K  IA++ +  A+L
Sbjct: 1774 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833

Query: 749  E-RIKVEKGQLESTLREKSQQLESLQEIKISLEEQLK-----KETAAK--ATVEQL---M 797
            E +++ E  + ++  +   Q+ + L+EI + +E++ K     KE A K  A V+QL   +
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893

Query: 798  FEEKNKAQR-------LQTELD 812
             E + ++QR       LQ ELD
Sbjct: 1894 EEAEEESQRINANRRKLQRELD 1915



 Score =  100 bits (249), Expect = 6e-21
 Identities = 172/820 (20%), Positives = 338/820 (41%), Gaps = 126/820 (15%)

Query: 59   RQNAVLQAAQDDLGHLRTQLWEAQAEMENIK---AIATVSENTKQEAIDEVKRQWRE--E 113
            RQ   +QA +D+L   + +  +A+ E++ ++   +  T  +N  QE +      + E  E
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQY---RESAEREIADLRRRLSEGQE-EEN 169
            +    A  K+ + +  H+   RLE+E  +  Q    R+   +++ DL  +L E +   + 
Sbjct: 916  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

Query: 170  LENEMKKAQEDAEKLRSVVMPM--------------EKEIAALKDKLTEAEDKIKEL--- 212
            L+ E   A+   +KL   ++ M              E+ I+ L   L E E+K K L   
Sbjct: 976  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1035

Query: 213  ---EASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE 269
                 S + EL   L+ E+  R +LE     L    S   E    L+ ++ E   L  Q 
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQL 1092

Query: 270  RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRL 329
             ++  +L+    + +D+  +    L             +++R++E      QED + +R 
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNAL-------------KKIRELEGHISDLQEDLDSERA 1139

Query: 330  NKRKDHK-KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
             + K  K K D+ EE++       T+ E +   +  ++ L + R      +  +L  + D
Sbjct: 1140 ARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALD 1191

Query: 389  PFSKSDNDMFKD-GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADS 447
              ++S     ++   + AQ+ + L       ++ L    +AK+  NLD++          
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEEL-------TEQLEQFKRAKA--NLDKNK------QTL 1236

Query: 448  VSENFDTAS----LGSLQMPSGFMLTK--DQERAIKAMTPEQEETASLLSSVTQGMESAY 501
              EN D A     LG  +        K   Q + +++   + E   + L+     +++  
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296

Query: 502  VSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQ 561
             S +G    +E +   L K+V +  ++L        + ++ LQ    Q+     ++++L+
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQL-------QDTQELLQEETRQKLNVSTKLRQLE 1349

Query: 562  LMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQ---QGLS 618
                   DQL++ M+ KQ LE             IS L ++   S+  L++     + L 
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLE-----------RHISTLNIQLSDSKKKLQDFASTVEALE 1398

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALR 678
            + K+  Q+++  L Q  E+ +    +L+K  + LQ         Q+ +D ++        
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ---------QELDDLVV-------- 1441

Query: 679  ELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEI 738
                    D+ N R    ++E+K +     L E+   +    +  +E  + E E  ++E 
Sbjct: 1442 --------DLDNQRQLVSNLEKKQRKFDQLLAEE---KNISSKYADERDRAEAEAREKET 1490

Query: 739  ASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMF 798
             ++S  +A LE     K +LE T +    ++E L   K  + + + +   +K  +E  M 
Sbjct: 1491 KALSLARA-LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 799  EEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQA 838
            E K + + L+ EL  +E  +       Q L+ Q ER  QA
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589



 Score =  100 bits (249), Expect = 6e-21
 Identities = 199/968 (20%), Positives = 383/968 (39%), Gaps = 192/968 (19%)

Query: 19   AELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH----L 74
            AE E++       +Q+LE+  ++  A+ +E     EED  +Q   LQA +  +      L
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEMEARLEE-----EEDRGQQ---LQAERKKMAQQMLDL 962

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDE--VKRQWREEVASLQAVMKETVRDYEHQF 132
              QL E +A  + ++     +E   ++  DE  V      +++  + +++E + D     
Sbjct: 963  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT-- 1020

Query: 133  HLRLEQERTQ-WAQYRESAEREIADLRRRLS-EGQEEENLENEMKKAQEDAEKLRSVVMP 190
            +L  E+E+ +   + +   E  I++L  RL  E +  + LE   +K + DA      +  
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 191  MEKEIAALKDKLTEAED---------------------KIKELEASKVKELNHYLEAEKS 229
            ++ +IA LK +L + E+                     KI+ELE   + +L   L++E++
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH-ISDLQEDLDSERA 1139

Query: 230  CRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQ 286
             R   E        QK  L E+ E L+ EL +       +QE R +  Q     +KA D+
Sbjct: 1140 ARNKAEK-------QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 287  FLESQRLLMRDMQRMEIVLTSEQLRQVEELKK-KDQEDDEQQRLNKRK------------ 333
               S    +++M++       E   Q+E+ K+ K   D  +Q L K              
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252

Query: 334  -----DHKKADVEEEIKIPVVCALTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLL 384
                 +HKK  +E +++         E + A+L+++    +  ++S  G ++  +   + 
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312

Query: 385  PSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVG 444
             + D  S S        L + ++   L  S  L+      N        LDE     +  
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEE----MEA 1365

Query: 445  ADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSP 504
              ++  +  T ++   Q+       +D    ++A+   ++     + ++TQ  E      
Sbjct: 1366 KQNLERHISTLNI---QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KA 1419

Query: 505  SGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI---------------- 548
            + Y  + +T+ N LQ+E+ +    L  +  + SN EK+ +                    
Sbjct: 1420 AAYDKLEKTK-NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478

Query: 549  --QEAETRDQVKKLQLMLR------QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISAL 599
               EAE R++  K   + R      +A ++LE+T K  K E+ED +  S +D    +  L
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS-SKDDVGKNVHEL 1537

Query: 600  VLRAQASEILLEELQQGLS------QAKRDVQEQMAVLMQSR------------EQVSEE 641
                +A E  +EE++  L       QA  D + ++ V MQ+             EQ  E+
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597

Query: 642  LVRLQKDNDSLQ---------------GKHSLHVSLQQAE---DFILPDTTEALREL--- 680
              +LQ+     +                K  L   L+  E   D  +    EA+++L   
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657

Query: 681  ---VLKYREDIINVRTAADHV----------EEKLKAEILFLKEQIQAEQCLKENLEETL 727
               +  ++ ++ + R + D +           + L+A+++ L+E + A     E   +  
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA----ERARKQA 1713

Query: 728  QLEIENCKEEIAS------------------ISSLKAELERIKVEKGQLESTLREKSQQL 769
             LE E   EE+AS                  I+ L+ ELE  +     +   +R+ +QQ 
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773

Query: 770  ESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQ 829
            E L     S E   ++ TA K    +   E +NK  R +   ++   V+  F      L+
Sbjct: 1774 EQL-----SNELATERSTAQKNESARQQLERQNKELRSKLH-EMEGAVKSKFKSTIAALE 1827

Query: 830  VQLERIRQ 837
             ++ ++ +
Sbjct: 1828 AKIAQLEE 1835



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/700 (21%), Positives = 310/700 (44%), Gaps = 91/700 (13%)

Query: 192  EKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
            E E+   K++  +AE+++KELE   S++ E  + L+ +    T+L      +  + +  +
Sbjct: 865  EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLE-SQRLLMRDMQRMEIVLTSE 308
            ++ E++   LHE+   LE+E  +  QL+   +K   Q L+  ++L   +  R ++ L  E
Sbjct: 925  QELEEI---LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL--E 979

Query: 309  QLRQVEELKKKDQE----DDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ---- 360
            ++    ++KK + E    DD+  +L+K +      +EE I   +   L +EE  A+    
Sbjct: 980  KVTAEAKIKKLEDEILVMDDQNNKLSKERKL----LEERIS-DLTTNLAEEEEKAKNLTK 1034

Query: 361  LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420
            L N+ E +      +  L+  L     +  S+ + +  K  L    ++D       LQ++
Sbjct: 1035 LKNKHESM------ISELEVRL---KKEEKSRQELEKLKRKLE-GDASDFHEQIADLQAQ 1084

Query: 421  ALGYNYKAKSAGNLDESDFGPLVGADSVSE-NFDTASLGSLQMP-SGFMLTKDQERAIKA 478
                  K + A   +E         D +++ N     +  L+   S      D ERA + 
Sbjct: 1085 IA--ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142

Query: 479  MTPEQ-----EETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRC 533
               +Q     EE  +L + +   ++S   +    R   E E  +L+K +           
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDST-ATQQELRAKREQEVTVLKKALD---------- 1191

Query: 534  DMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSS 593
            +   ++E Q+Q ++ + A+  +++ +     ++A   L+K   +KQ LE       ++++
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLE-------KENA 1241

Query: 594  HQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQ 653
                 L +  QA + + E  ++ L    +++Q + +   ++R ++++++ +LQ + +S+ 
Sbjct: 1242 DLAGELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300

Query: 654  G--KHSLHVSLQQAEDFI-LPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
            G    +   +++ A+D   L    +  +EL+ +     +NV T    +EE+  +    L+
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS----LQ 1356

Query: 711  EQIQAEQCLKENLEE---TLQLEIENCKEEIASISSLKAELE----RIKVEKGQLESTLR 763
            +Q+  E   K+NLE    TL +++ + K+++   +S    LE    R + E   L     
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 764  EKSQQLESLQEIKISLEEQLKKETA--------------AKATVEQLMFEEKNKAQRLQT 809
            EK+   + L++ K  L+++L                    +   +QL+ EEKN + +   
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 810  ELDVSEQVQRDFVKLSQTLQVQLERIRQA-DSLERIRAIL 848
            E D +E   R+    + +L   LE   +A + LER   +L
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 72/332 (21%), Positives = 138/332 (41%), Gaps = 67/332 (20%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAV---LQAAQDDL 71
            ++ + +L K+ A+    Q++LE      RA   E++   +E+ K+  ++   L   Q+DL
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDA----RASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
                    +A  E E + A    S  + + A+ + KR+    +A L+  ++E       Q
Sbjct: 1704 AAAERARKQADLEKEEL-AEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQ 1756

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPM 191
             ++    +R + A                    Q+ E L NE+   +  A+K  S    +
Sbjct: 1757 GNMEAMSDRVRKAT-------------------QQAEQLSNELATERSTAQKNESARQQL 1797

Query: 192  EKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQED 251
            E++   L+ KL E E  +K    SK K     LEA+ +    LE  V     +K    + 
Sbjct: 1798 ERQNKELRSKLHEMEGAVK----SKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKS 1850

Query: 252  AEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLR 311
             ++  K+L E+   +E ER+   Q K   +K N                           
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--------------------------A 1884

Query: 312  QVEELKKK-DQEDDEQQRLNKRKDHKKADVEE 342
            +V++LK++ ++ ++E QR+N  +   + +++E
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 61/298 (20%), Positives = 131/298 (43%), Gaps = 22/298 (7%)

Query: 556  QVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQ 615
            QV + +  ++   D+L+KT + +Q+ E+ +K+  +  S          +   +L E+LQ 
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQL-------TEEKNLLQEQLQA 905

Query: 616  G--LSQAKRDVQEQMAVLMQSREQVSEEL-VRLQKDNDSLQGKHSLHVSLQQAEDFILPD 672
               L     +++ ++A   Q  E++  E+  RL+++ D  Q   +    + Q     + D
Sbjct: 906  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ----MLD 961

Query: 673  TTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIE 732
              E L E     R+ +   +  A+   +KL+ EIL + +Q       ++ LEE +     
Sbjct: 962  LEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020

Query: 733  NCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE-------EQLKK 785
            N  EE     +L     + +    +LE  L+++ +  + L+++K  LE       EQ+  
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 786  ETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
              A  A ++  + +++ + Q     LD     + + +K  + L+  +  +++    ER
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 26/154 (16%)

Query: 719 LKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKIS 778
           +K  L+ T Q E    KE+         EL++ K  + + E+ L+E  Q+   L E K  
Sbjct: 848 VKPLLQVTRQEEEMQAKED---------ELQKTKERQQKAENELKELEQKHSQLTEEKNL 898

Query: 779 LEEQLKKETAAKATVEQLMFEEKNKAQ-----------RLQTELDVSEQVQRDFVKLSQ- 826
           L+EQL+ ET   A  E++      K Q           RL+ E D  +Q+Q +  K++Q 
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958

Query: 827 --TLQVQLER---IRQADSLERIRAILNDTKLTD 855
              L+ QLE     RQ   LE++ A     KL D
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 992



 Score = 37.7 bits (86), Expect = 0.046
 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 3/103 (2%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD-- 70
            +L+ ++A+LE+   +  R +Q   +   QK  K KE+ L  E++ K      + A+    
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884

Query: 71   -LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWRE 112
             +  L+ QL EA+ E + I A     +    EA +  +   RE
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  109 bits (272), Expect = 1e-23
 Identities = 186/874 (21%), Positives = 368/874 (42%), Gaps = 125/874 (14%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQE--FNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            QQ  AE +K+  + L  ++QLE+E    QK    K    AK + L+ +  V+    + L 
Sbjct: 939  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 73   HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQF 132
              R  L E  +++    A     E  K + + ++K +    ++ L+  +K+     E + 
Sbjct: 999  KERKLLEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKK-----EEKS 1049

Query: 133  HLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
               LE+ + +          +IADL+ +++E      L+ ++ K +E+   L++ +  ++
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAE------LKMQLAKKEEE---LQAALARLD 1100

Query: 193  KEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDA 252
             EIA   + L     KI+ELE   + +L   L++E++ R   E        QK  L E+ 
Sbjct: 1101 DEIAQKNNAL----KKIRELE-GHISDLQEDLDSERAARNKAE-------KQKRDLGEEL 1148

Query: 253  EKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
            E L+ EL +       +QE R +  Q     +KA D+   S    +++M++       E 
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208

Query: 310  LRQVEELKK-KDQEDDEQQRLNKRK-----------------DHKKADVEEEIKIPVVCA 351
              Q+E+ K+ K   D  +Q L K                   +HKK  +E +++      
Sbjct: 1209 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1268

Query: 352  LTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQS 407
               E + A+L+++    +  ++S  G ++  +   +  + D  S S        L + ++
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328

Query: 408  TDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFM 467
               L  S  L+      N        LDE     +    ++  +  T    ++Q+     
Sbjct: 1329 RQKLNVSTKLRQLEEERN---SLQDQLDEE----MEAKQNLERHISTL---NIQLSDSKK 1378

Query: 468  LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
              +D    ++A+   ++     + ++TQ  E      + Y  + +T+ N LQ+E+ +   
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTK-NRLQQELDDLVV 1434

Query: 528  KLGRRCDMCSNYEKQLQGI------------------QIQEAETRDQVKKLQLMLR---- 565
             L  +  + SN EK+ +                       EAE R++  K   + R    
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494

Query: 566  --QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKR 622
              +A ++LE+T K  K E+ED +  S +D    +  L    +A E  +EE++  L + + 
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLV-SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553

Query: 623  DVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVL 682
            ++Q              +  +RL+ +  +L+G+    +   QA D    +    L+  + 
Sbjct: 1554 ELQ-----------ATEDAKLRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH 1599

Query: 683  KYR---EDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIA 739
            +Y    ED    R  A   ++KL+ ++  L  ++QA+  +K   E   QL     ++  A
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQL-----RKLQA 1652

Query: 740  SISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
             +   + ELE  +  + ++ +T +E  ++ +SL+   + L+E L    AA+   +Q   E
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL---AAAERARKQADLE 1709

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLE 833
            ++  A+ L + L     +Q +  +L   +  QLE
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARI-AQLE 1742



 Score =  101 bits (252), Expect = 3e-21
 Identities = 193/862 (22%), Positives = 387/862 (44%), Gaps = 90/862 (10%)

Query: 14   LQQRVAELE----KINAEFLRAQQQLEQEFNQKRAKFKELYLAK------EEDLKRQNAV 63
            LQ ++AEL+    K   E   A  +L+ E  QK    K++   +      +EDL  + A 
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133

Query: 64   LQAAQD---DLGH----LRTQL---WEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE 113
               A+    DLG     L+T+L    ++ A  + ++A         ++A+DE  R    +
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSE-GQEEENLEN 172
            V  ++    + V +   Q   + ++ +    + +++ E+E ADL   L   GQ ++ +E+
Sbjct: 1194 VQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252

Query: 173  EMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRT 232
            + KK +   ++L+S     E+  A L DK+ + +++++ +       LN   EAE     
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM----LN---EAEGKA-I 1304

Query: 233  DLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQR 292
             L   VA L++Q   LQ+  E L++E  +  ++  + RQ   + +++ Q   D+ +E+++
Sbjct: 1305 KLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQ 1360

Query: 293  LLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCAL 352
             L R +  + I L+  + +  +     +  ++ ++R  K  ++     EE+         
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAG------LLLPSGDPFSK-SDNDMFKDGLRRA 405
            T+     +L +    LD+ R  V +L+        LL    +  SK +D     +   R 
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 406  QSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA-DSVSENFDTASLGSLQMPS 464
            + T +L  + +L+ +AL    + +    + +++   LV + D V +N          + +
Sbjct: 1481 KETKALSLARALE-EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 465  GFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR-LVSETEWNLLQKEVH 523
                 K Q   ++      E+    L    Q ++  +      R   +E +   LQ+++H
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599

Query: 524  NAGNKLG---RRCDMCSNYEKQLQG-IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQ 579
                +L    ++  + +  +K+L+G ++  E +    +K  +  ++Q   +L+  MKD Q
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKDFQ 1658

Query: 580  -ELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQV 638
             ELED  + S ++          +A++ E  L +LQ+ L+ A+R    + A L   +E++
Sbjct: 1659 RELED-ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER--ARKQADL--EKEEL 1713

Query: 639  SEELVRLQKDNDSLQG-KHSLHVSLQQAEDFILPD--TTEALRELVLKYREDIINVRTAA 695
            +EEL       ++LQ  K  L   + Q E+ +  +    EA+ + V K  +        A
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ-------A 1766

Query: 696  DHVEEKLKAEILFLKEQIQAEQCL-KENLEETLQL-EIENC-----KEEIASISSLKAEL 748
            + +  +L  E    ++   A Q L ++N E   +L E+E       K  IA++ +  A+L
Sbjct: 1767 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826

Query: 749  E-RIKVEKGQLESTLREKSQQLESLQEIKISLEEQLK-----KETAAK--ATVEQL---M 797
            E +++ E  + ++  +   Q+ + L+EI + +E++ K     KE A K  A V+QL   +
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886

Query: 798  FEEKNKAQR-------LQTELD 812
             E + ++QR       LQ ELD
Sbjct: 1887 EEAEEESQRINANRRKLQRELD 1908



 Score =  100 bits (249), Expect = 6e-21
 Identities = 172/820 (20%), Positives = 338/820 (41%), Gaps = 126/820 (15%)

Query: 59   RQNAVLQAAQDDLGHLRTQLWEAQAEMENIK---AIATVSENTKQEAIDEVKRQWRE--E 113
            RQ   +QA +D+L   + +  +A+ E++ ++   +  T  +N  QE +      + E  E
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQY---RESAEREIADLRRRLSEGQE-EEN 169
            +    A  K+ + +  H+   RLE+E  +  Q    R+   +++ DL  +L E +   + 
Sbjct: 909  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968

Query: 170  LENEMKKAQEDAEKLRSVVMPM--------------EKEIAALKDKLTEAEDKIKEL--- 212
            L+ E   A+   +KL   ++ M              E+ I+ L   L E E+K K L   
Sbjct: 969  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1028

Query: 213  ---EASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE 269
                 S + EL   L+ E+  R +LE     L    S   E    L+ ++ E   L  Q 
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQL 1085

Query: 270  RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRL 329
             ++  +L+    + +D+  +    L             +++R++E      QED + +R 
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNAL-------------KKIRELEGHISDLQEDLDSERA 1132

Query: 330  NKRKDHK-KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
             + K  K K D+ EE++       T+ E +   +  ++ L + R      +  +L  + D
Sbjct: 1133 ARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALD 1184

Query: 389  PFSKSDNDMFKD-GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADS 447
              ++S     ++   + AQ+ + L       ++ L    +AK+  NLD++          
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEEL-------TEQLEQFKRAKA--NLDKNK------QTL 1229

Query: 448  VSENFDTAS----LGSLQMPSGFMLTK--DQERAIKAMTPEQEETASLLSSVTQGMESAY 501
              EN D A     LG  +        K   Q + +++   + E   + L+     +++  
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289

Query: 502  VSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQ 561
             S +G    +E +   L K+V +  ++L        + ++ LQ    Q+     ++++L+
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQL-------QDTQELLQEETRQKLNVSTKLRQLE 1342

Query: 562  LMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQ---QGLS 618
                   DQL++ M+ KQ LE             IS L ++   S+  L++     + L 
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLE-----------RHISTLNIQLSDSKKKLQDFASTVEALE 1391

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALR 678
            + K+  Q+++  L Q  E+ +    +L+K  + LQ         Q+ +D ++        
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ---------QELDDLVV-------- 1434

Query: 679  ELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEI 738
                    D+ N R    ++E+K +     L E+   +    +  +E  + E E  ++E 
Sbjct: 1435 --------DLDNQRQLVSNLEKKQRKFDQLLAEE---KNISSKYADERDRAEAEAREKET 1483

Query: 739  ASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMF 798
             ++S  +A LE     K +LE T +    ++E L   K  + + + +   +K  +E  M 
Sbjct: 1484 KALSLARA-LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 799  EEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQA 838
            E K + + L+ EL  +E  +       Q L+ Q ER  QA
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582



 Score =  100 bits (249), Expect = 6e-21
 Identities = 199/968 (20%), Positives = 383/968 (39%), Gaps = 192/968 (19%)

Query: 19   AELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH----L 74
            AE E++       +Q+LE+  ++  A+ +E     EED  +Q   LQA +  +      L
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEMEARLEE-----EEDRGQQ---LQAERKKMAQQMLDL 955

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDE--VKRQWREEVASLQAVMKETVRDYEHQF 132
              QL E +A  + ++     +E   ++  DE  V      +++  + +++E + D     
Sbjct: 956  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT-- 1013

Query: 133  HLRLEQERTQ-WAQYRESAEREIADLRRRLS-EGQEEENLENEMKKAQEDAEKLRSVVMP 190
            +L  E+E+ +   + +   E  I++L  RL  E +  + LE   +K + DA      +  
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 191  MEKEIAALKDKLTEAED---------------------KIKELEASKVKELNHYLEAEKS 229
            ++ +IA LK +L + E+                     KI+ELE   + +L   L++E++
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH-ISDLQEDLDSERA 1132

Query: 230  CRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQ 286
             R   E        QK  L E+ E L+ EL +       +QE R +  Q     +KA D+
Sbjct: 1133 ARNKAEK-------QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 287  FLESQRLLMRDMQRMEIVLTSEQLRQVEELKK-KDQEDDEQQRLNKRK------------ 333
               S    +++M++       E   Q+E+ K+ K   D  +Q L K              
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245

Query: 334  -----DHKKADVEEEIKIPVVCALTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLL 384
                 +HKK  +E +++         E + A+L+++    +  ++S  G ++  +   + 
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305

Query: 385  PSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVG 444
             + D  S S        L + ++   L  S  L+      N        LDE     +  
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEE----MEA 1358

Query: 445  ADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSP 504
              ++  +  T ++   Q+       +D    ++A+   ++     + ++TQ  E      
Sbjct: 1359 KQNLERHISTLNI---QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KA 1412

Query: 505  SGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI---------------- 548
            + Y  + +T+ N LQ+E+ +    L  +  + SN EK+ +                    
Sbjct: 1413 AAYDKLEKTK-NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471

Query: 549  --QEAETRDQVKKLQLMLR------QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISAL 599
               EAE R++  K   + R      +A ++LE+T K  K E+ED +  S +D    +  L
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS-SKDDVGKNVHEL 1530

Query: 600  VLRAQASEILLEELQQGLS------QAKRDVQEQMAVLMQSR------------EQVSEE 641
                +A E  +EE++  L       QA  D + ++ V MQ+             EQ  E+
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590

Query: 642  LVRLQKDNDSLQ---------------GKHSLHVSLQQAE---DFILPDTTEALREL--- 680
              +LQ+     +                K  L   L+  E   D  +    EA+++L   
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650

Query: 681  ---VLKYREDIINVRTAADHV----------EEKLKAEILFLKEQIQAEQCLKENLEETL 727
               +  ++ ++ + R + D +           + L+A+++ L+E + A     E   +  
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA----ERARKQA 1706

Query: 728  QLEIENCKEEIAS------------------ISSLKAELERIKVEKGQLESTLREKSQQL 769
             LE E   EE+AS                  I+ L+ ELE  +     +   +R+ +QQ 
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766

Query: 770  ESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQ 829
            E L     S E   ++ TA K    +   E +NK  R +   ++   V+  F      L+
Sbjct: 1767 EQL-----SNELATERSTAQKNESARQQLERQNKELRSKLH-EMEGAVKSKFKSTIAALE 1820

Query: 830  VQLERIRQ 837
             ++ ++ +
Sbjct: 1821 AKIAQLEE 1828



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 148/700 (21%), Positives = 310/700 (44%), Gaps = 91/700 (13%)

Query: 192  EKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
            E E+   K++  +AE+++KELE   S++ E  + L+ +    T+L      +  + +  +
Sbjct: 858  EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLE-SQRLLMRDMQRMEIVLTSE 308
            ++ E++   LHE+   LE+E  +  QL+   +K   Q L+  ++L   +  R ++ L  E
Sbjct: 918  QELEEI---LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL--E 972

Query: 309  QLRQVEELKKKDQE----DDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ---- 360
            ++    ++KK + E    DD+  +L+K +      +EE I   +   L +EE  A+    
Sbjct: 973  KVTAEAKIKKLEDEILVMDDQNNKLSKERKL----LEERIS-DLTTNLAEEEEKAKNLTK 1027

Query: 361  LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420
            L N+ E +      +  L+  L     +  S+ + +  K  L    ++D       LQ++
Sbjct: 1028 LKNKHESM------ISELEVRL---KKEEKSRQELEKLKRKLE-GDASDFHEQIADLQAQ 1077

Query: 421  ALGYNYKAKSAGNLDESDFGPLVGADSVSE-NFDTASLGSLQMP-SGFMLTKDQERAIKA 478
                  K + A   +E         D +++ N     +  L+   S      D ERA + 
Sbjct: 1078 IA--ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135

Query: 479  MTPEQ-----EETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRC 533
               +Q     EE  +L + +   ++S   +    R   E E  +L+K +           
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDST-ATQQELRAKREQEVTVLKKALD---------- 1184

Query: 534  DMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSS 593
            +   ++E Q+Q ++ + A+  +++ +     ++A   L+K   +KQ LE       ++++
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLE-------KENA 1234

Query: 594  HQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQ 653
                 L +  QA + + E  ++ L    +++Q + +   ++R ++++++ +LQ + +S+ 
Sbjct: 1235 DLAGELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293

Query: 654  G--KHSLHVSLQQAEDFI-LPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
            G    +   +++ A+D   L    +  +EL+ +     +NV T    +EE+  +    L+
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS----LQ 1349

Query: 711  EQIQAEQCLKENLEE---TLQLEIENCKEEIASISSLKAELE----RIKVEKGQLESTLR 763
            +Q+  E   K+NLE    TL +++ + K+++   +S    LE    R + E   L     
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 764  EKSQQLESLQEIKISLEEQLKKETA--------------AKATVEQLMFEEKNKAQRLQT 809
            EK+   + L++ K  L+++L                    +   +QL+ EEKN + +   
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 810  ELDVSEQVQRDFVKLSQTLQVQLERIRQA-DSLERIRAIL 848
            E D +E   R+    + +L   LE   +A + LER   +L
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 72/332 (21%), Positives = 138/332 (41%), Gaps = 67/332 (20%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAV---LQAAQDDL 71
            ++ + +L K+ A+    Q++LE      RA   E++   +E+ K+  ++   L   Q+DL
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDA----RASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
                    +A  E E + A    S  + + A+ + KR+    +A L+  ++E       Q
Sbjct: 1697 AAAERARKQADLEKEEL-AEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQ 1749

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPM 191
             ++    +R + A                    Q+ E L NE+   +  A+K  S    +
Sbjct: 1750 GNMEAMSDRVRKAT-------------------QQAEQLSNELATERSTAQKNESARQQL 1790

Query: 192  EKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQED 251
            E++   L+ KL E E  +K    SK K     LEA+ +    LE  V     +K    + 
Sbjct: 1791 ERQNKELRSKLHEMEGAVK----SKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKS 1843

Query: 252  AEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLR 311
             ++  K+L E+   +E ER+   Q K   +K N                           
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--------------------------A 1877

Query: 312  QVEELKKK-DQEDDEQQRLNKRKDHKKADVEE 342
            +V++LK++ ++ ++E QR+N  +   + +++E
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 61/298 (20%), Positives = 131/298 (43%), Gaps = 22/298 (7%)

Query: 556  QVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQ 615
            QV + +  ++   D+L+KT + +Q+ E+ +K+  +  S          +   +L E+LQ 
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQL-------TEEKNLLQEQLQA 898

Query: 616  G--LSQAKRDVQEQMAVLMQSREQVSEEL-VRLQKDNDSLQGKHSLHVSLQQAEDFILPD 672
               L     +++ ++A   Q  E++  E+  RL+++ D  Q   +    + Q     + D
Sbjct: 899  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ----MLD 954

Query: 673  TTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIE 732
              E L E     R+ +   +  A+   +KL+ EIL + +Q       ++ LEE +     
Sbjct: 955  LEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013

Query: 733  NCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE-------EQLKK 785
            N  EE     +L     + +    +LE  L+++ +  + L+++K  LE       EQ+  
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 786  ETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
              A  A ++  + +++ + Q     LD     + + +K  + L+  +  +++    ER
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 26/154 (16%)

Query: 719 LKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKIS 778
           +K  L+ T Q E    KE+         EL++ K  + + E+ L+E  Q+   L E K  
Sbjct: 841 VKPLLQVTRQEEEMQAKED---------ELQKTKERQQKAENELKELEQKHSQLTEEKNL 891

Query: 779 LEEQLKKETAAKATVEQLMFEEKNKAQ-----------RLQTELDVSEQVQRDFVKLSQ- 826
           L+EQL+ ET   A  E++      K Q           RL+ E D  +Q+Q +  K++Q 
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951

Query: 827 --TLQVQLER---IRQADSLERIRAILNDTKLTD 855
              L+ QLE     RQ   LE++ A     KL D
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 985



 Score = 37.7 bits (86), Expect = 0.046
 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 3/103 (2%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD-- 70
            +L+ ++A+LE+   +  R +Q   +   QK  K KE+ L  E++ K      + A+    
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877

Query: 71   -LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWRE 112
             +  L+ QL EA+ E + I A     +    EA +  +   RE
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920


>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
          Length = 1946

 Score =  103 bits (258), Expect = 5e-22
 Identities = 196/873 (22%), Positives = 379/873 (43%), Gaps = 120/873 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKEL--YLAKEEDLKRQNAVLQAAQDDL 71
            L +RV E E+IN+E     ++LE E  + + +  +L   L K E  KR        +  +
Sbjct: 934  LSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKR------TTEHKV 987

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
             +L  ++     ++  +   A V +   Q+ +D++  +  E+++SL     +  +  + +
Sbjct: 988  KNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHME-EEKLSSLSKANLKLEQQVD-E 1045

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEE-ENLENEMKKAQEDAEKLRSVVMP 190
                LEQER    + R + ERE+  L   L   +E  ENLE+  +   E+  K    +  
Sbjct: 1046 LEGALEQER----KARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQ 1101

Query: 191  MEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQE 250
            M  ++   K  + + +  +KEL+ +++K+L   LEAE++ R  +E        +++ L +
Sbjct: 1102 MNSKVENEKGLVAQLQKTVKELQ-TQIKDLKEKLEAERTTRAKME-------RERADLTQ 1153

Query: 251  DAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQL 310
            D   L + L EV            QL+ T +K   +F +  R +       E    S + 
Sbjct: 1154 DLADLNERLEEV------GGSSLAQLEIT-KKQETKFQKLHRDMEEATLHFETTSASLKK 1206

Query: 311  RQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQ-EESSAQLSNEEEHLD 369
            R  + L + + + +  Q++ ++ +  K+D++ E+       LT+ E+ +   +N E+   
Sbjct: 1207 RHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVD----DLLTRVEQMTRAKANAEKLCT 1262

Query: 370  STRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAK 429
                 +H   A L     D  ++  ND+       AQ T     SG    +         
Sbjct: 1263 LYEERLHEATAKL-----DKVTQLANDL------AAQKTKLWSESGEFLRR--------- 1302

Query: 430  SAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASL 489
                L+E +   L+   S  ++  T  +  L+       TK Q     A+   Q +   L
Sbjct: 1303 ----LEEKE--ALINQLSREKSNFTRQIEDLRGQLE-KETKSQSALAHALQKAQRDCDLL 1355

Query: 490  LSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQ 549
                 +  E   V    +R +S+    ++Q  +    N + R  D+  + +K+L  I++Q
Sbjct: 1356 REQYEEEQE---VKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDL-EDAKKEL-AIRLQ 1410

Query: 550  E-AETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEI 608
            E AE           L +A  QL+  + D   L D  K              +R+ A+ +
Sbjct: 1411 EAAEAMGVANARNASLERARHQLQLELGD--ALSDLGK--------------VRSAAARL 1454

Query: 609  LLEELQQG--LSQAKRDVQEQMAVLMQSREQV---SEELVRLQKD-NDSLQGKHSLHVSL 662
              ++LQ G  L+  K+  +E  A+L  S+++V   S EL++L+    +S+ G+ +L    
Sbjct: 1455 DQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRREN 1514

Query: 663  QQAEDFILPDTT------------EALRELVLKYREDIINVRTAADHVEEKLKAEIL-FL 709
            +  ++ I   T             E +++L+ + + ++       +   E+ +++IL F 
Sbjct: 1515 KNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQ 1574

Query: 710  KEQIQAEQCLKENLEETLQLEIENC-KEEIASISSLKAELERIKVEKGQLESTLREKSQQ 768
             E ++A+  L+  L E  + EIEN  +++  +I SL++ L+     K ++E T R K + 
Sbjct: 1575 LELLEAKAELERKLSEKDE-EIENFRRKQQCTIDSLQSSLD--SEAKSRIEVT-RLKKKM 1630

Query: 769  LESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDF------- 821
             E L E+++ L    ++ + A  ++ QL  + K+    LQ +LD S Q+  D        
Sbjct: 1631 EEDLNEMELQLSCANRQVSEATKSLGQLQIQIKD----LQMQLDDSTQLNSDLKEQVAVA 1686

Query: 822  VKLSQTLQVQLERIRQ-ADSLERIRAILNDTKL 853
             + +  LQ +LE +R   +  ER R +  +  L
Sbjct: 1687 ERRNSLLQSELEDLRSLQEQTERGRRLSEEELL 1719



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 169/882 (19%), Positives = 353/882 (40%), Gaps = 147/882 (16%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAA 67
            S+ ++ L+Q+V ELE    +  +A+   E+E ++            E +LK     ++  
Sbjct: 1033 SKANLKLEQQVDELEGALEQERKARMNCERELHKL-----------EGNLKLNRESMENL 1081

Query: 68   QDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRD 127
            +    HL  +L + + E+  +        N+K E    +  Q ++ V  LQ  +K+    
Sbjct: 1082 ESSQRHLAEELRKKELELSQM--------NSKVENEKGLVAQLQKTVKELQTQIKDLKEK 1133

Query: 128  YEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDA-----E 182
             E +   R + ER      R    +++ADL  RL E       + E+ K QE        
Sbjct: 1134 LEAERTTRAKMERE-----RADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHR 1188

Query: 183  KLRSVVMPMEKEIAALK----DKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
             +    +  E   A+LK    D L E E +++ L+  K K     LE +KS   DL++ V
Sbjct: 1189 DMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQK-----LEKDKS---DLQLEV 1240

Query: 239  AVLNT---QKSVLQEDAEKL----RKELHEVCHLLEQERQQHNQLK----HTWQKAND-- 285
              L T   Q +  + +AEKL     + LHE    L++  Q  N L       W ++ +  
Sbjct: 1241 DDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFL 1300

Query: 286  QFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQ--------RLNKRKDHKK 337
            + LE +  L+  + R +   T    RQ+E+L+ + +++ + Q        +  +  D  +
Sbjct: 1301 RRLEEKEALINQLSREKSNFT----RQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLR 1356

Query: 338  ADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM 397
               EEE ++      T  + +A++       ++            ++   +    +  ++
Sbjct: 1357 EQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENN-----------VIQRTEDLEDAKKEL 1405

Query: 398  FKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASL 457
                +R  ++ +++G + +  +      ++ +       SD G +  A         A L
Sbjct: 1406 ---AIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSA--------AARL 1454

Query: 458  GSLQMPSGFMLT--KDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEW 515
               Q+ SG  L   K +    +A+    ++    LS+    +++ Y      +     E 
Sbjct: 1455 DQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRREN 1514

Query: 516  NLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETR--------------DQVKKLQ 561
              LQ+E+ N  N++       +  EK  + I+ ++ E +               ++   Q
Sbjct: 1515 KNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQ 1574

Query: 562  LMLRQANDQLEKTMKDK-QELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGL-SQ 619
            L L +A  +LE+ + +K +E+E+F ++                   +  ++ LQ  L S+
Sbjct: 1575 LELLEAKAELERKLSEKDEEIENFRRKQ------------------QCTIDSLQSSLDSE 1616

Query: 620  AKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRE 679
            AK  +                E+ RL+K  +    +  L +S    +   + + T++L +
Sbjct: 1617 AKSRI----------------EVTRLKKKMEEDLNEMELQLSCANRQ---VSEATKSLGQ 1657

Query: 680  LVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIA 739
            L ++ + D+      +  +   LK ++   + +      L+  LE+   L+ +  +    
Sbjct: 1658 LQIQIK-DLQMQLDDSTQLNSDLKEQVAVAERR---NSLLQSELEDLRSLQEQTERGRRL 1713

Query: 740  SISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
            S   L    ERI +   Q  S L +K +    +  ++   EE +++   A+   ++   E
Sbjct: 1714 SEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIE 1773

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSL 841
              N ++ L+ + D    ++R    + QT+    +R+ +A+ +
Sbjct: 1774 AANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQM 1815



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 164/821 (19%), Positives = 346/821 (42%), Gaps = 100/821 (12%)

Query: 1    MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFK---ELYLAKEEDL 57
            +AQ     + +   Q+   ++E+    F      L++      A+ +   E     ++ L
Sbjct: 1170 LAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKL 1229

Query: 58   KRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASL 117
            ++  + LQ   DDL     Q+  A+A   N + + T+ E    EA  ++ +    ++A+ 
Sbjct: 1230 EKDKSDLQLEVDDLLTRVEQMTRAKA---NAEKLCTLYEERLHEATAKLDKV--TQLAND 1284

Query: 118  QAVMKETVRDYEHQFHLRLEQERT---QWAQYRESAEREIADLRRRLS-EGQEEENLENE 173
             A  K  +     +F  RLE++     Q ++ + +  R+I DLR +L  E + +  L + 
Sbjct: 1285 LAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHA 1344

Query: 174  MKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKE----LEASKVKELNHYLEAEKS 229
            ++KAQ D + LR      ++  A L   L++   ++ +     E + ++      +A+K 
Sbjct: 1345 LQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKE 1404

Query: 230  CRTDLEMY---VAVLNTQKSVLQEDAEKLRKELHEVCH----------LLEQERQQHNQL 276
                L+     + V N + + L+    +L+ EL +              L+Q++ Q  + 
Sbjct: 1405 LAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKA 1464

Query: 277  KHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHK 336
               W++ ++   ESQ LL    + ++  L++E L+     ++     +  +R NK    +
Sbjct: 1465 LADWKQKHE---ESQALLDASQKEVQ-ALSTELLKLKNTYEESIVGQETLRRENKNLQEE 1520

Query: 337  KADVEEEIKIPVVCALTQEESSAQLSNEEEH-----LDSTRGSVHSLDAGLL------LP 385
             +++  +++      LT+ E   +L  EE+      L+ T G++   ++ +L      L 
Sbjct: 1521 ISNLTNQVREGTK-NLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLE 1579

Query: 386  SGDPFSK--SDNDMFKDGLRRAQSTDSLGTSGSLQSKALGY----NYKAKSAGNLDESDF 439
            +     +  S+ D   +  RR Q         SL S+A         K K   +L+E + 
Sbjct: 1580 AKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMEL 1639

Query: 440  GPLVGADSVSENFDTASLGSLQMP-SGFMLTKDQERAIKAMTPEQ----EETASLLSSVT 494
                    VSE   T SLG LQ+      +  D    + +   EQ    E   SLL S  
Sbjct: 1640 QLSCANRQVSEA--TKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSEL 1697

Query: 495  QGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETR 554
            + + S        R +SE E  LL+                     +++     Q     
Sbjct: 1698 EDLRSLQEQTERGRRLSEEE--LLEAT-------------------ERINLFYTQNTSLL 1736

Query: 555  DQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQ 614
             Q KKL+  + +   + E+ +++ Q  E+  K+++ ++++ +S  + + Q +   LE  +
Sbjct: 1737 SQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAAN-LSEELKKKQDTIAHLERTR 1795

Query: 615  QGLSQAKRDVQEQMA-----VLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFI 669
            + + Q   D+Q+++A      LM SR+Q+ +   R+++    L+G+       Q+    +
Sbjct: 1796 ENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRL 1855

Query: 670  LPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQI-----QAEQCLKENLE 724
                   ++EL  +  ED  N+      + +KL+ ++   K+Q+     QA Q L +  +
Sbjct: 1856 ----ERCIKELTYQAEEDKKNLSRMQTQM-DKLQLKVQNYKQQVEVAETQANQYLSKYKK 1910

Query: 725  ETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREK 765
            +  +L     + E+A     ++++ ++K++  +    ++E+
Sbjct: 1911 QQHELNEVKERAEVA-----ESQVNKLKIKAREFGKKVQEE 1946



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 156/850 (18%), Positives = 356/850 (41%), Gaps = 77/850 (9%)

Query: 41   QKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQ 100
            Q RA+ K + +  ++ L+ ++A++    +    +  + W        IK +   SE    
Sbjct: 801  QARAQGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSE---- 856

Query: 101  EAIDEVKRQWREEVASLQAVMK--ETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLR 158
              + E     +EE A LQ  ++  E  R+      + L QE+       ++ +  +A++ 
Sbjct: 857  --VGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVE 914

Query: 159  RRLSEGQEEE-NLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKV 217
             +     + +  LE  +K+  E  E+   +   +      L+D+  E + +I +LE   V
Sbjct: 915  EQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLV 974

Query: 218  KELNHYLEAE---KSCRTDLEMY---VAVLNTQKSVLQEDAEKLRKELH---EVCHLLEQ 268
            K        E   K+   ++E     ++ LN    V+QE  ++   +LH   E    L +
Sbjct: 975  KSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSK 1034

Query: 269  ERQQHNQLKHTWQKANDQFLESQRLLMRDMQRME--IVLTSEQLRQVEELKKKDQEDDEQ 326
               +  Q     + A +Q  +++    R++ ++E  + L  E +  +E  ++   E+  +
Sbjct: 1035 ANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRK 1094

Query: 327  QRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPS 386
            + L   + + K  VE E  +      T +E   Q+ + +E L++ R +   ++       
Sbjct: 1095 KELELSQMNSK--VENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMER------ 1146

Query: 387  GDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPL-VGA 445
                             RA  T  L        +  G +          E+ F  L    
Sbjct: 1147 ----------------ERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDM 1190

Query: 446  DSVSENFDTASLGSLQMPSGFMLT--KDQERAIKAMTPEQEETASLLSSVTQGMESAYVS 503
            +  + +F+T S  SL+      L   + Q   ++ +  + E+  S L      + +    
Sbjct: 1191 EEATLHFETTS-ASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQ 1249

Query: 504  PSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLM 563
             +  +  +E    L ++ +H A  KL +   + ++   Q   +  +  E   ++++ + +
Sbjct: 1250 MTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEAL 1309

Query: 564  LRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEIL---LEELQQGLSQA 620
            + Q + +     +  ++L   +++ ++  S    AL    +  ++L    EE Q+  ++ 
Sbjct: 1310 INQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAEL 1369

Query: 621  KRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFI------LPDTT 674
             R + +  A ++Q R +    ++  Q+  D    K  L + LQ+A + +           
Sbjct: 1370 HRTLSKVNAEMVQWRMKYENNVI--QRTEDLEDAKKELAIRLQEAAEAMGVANARNASLE 1427

Query: 675  EALRELVLKYRE---DIINVRTAADHVEEKLKAE---ILFLKEQIQAEQCLKENLEETLQ 728
             A  +L L+  +   D+  VR+AA  +++K       +   K++ +  Q L +  ++ +Q
Sbjct: 1428 RARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQ 1487

Query: 729  ------LEIENCKEE-IASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEE 781
                  L+++N  EE I    +L+ E + ++ E   L + +RE ++ L  ++++K  +EE
Sbjct: 1488 ALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEE 1547

Query: 782  QLKKETAAKATVEQLMFE-EKNKAQRLQTELDVSEQVQRDFVKLSQ-TLQVQLERIRQAD 839
            +   +T  + T+E+     E+N+++ L  +L++ E       KLS+   +++  R +Q  
Sbjct: 1548 E---KTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQC 1604

Query: 840  SLERIRAILN 849
            +++ +++ L+
Sbjct: 1605 TIDSLQSSLD 1614



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 72/336 (21%), Positives = 151/336 (44%), Gaps = 52/336 (15%)

Query: 548  IQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASE 607
            ++ +E  ++V  L+    Q    LEK+   ++EL    K      + + + L+L+ QA +
Sbjct: 852  VKSSEVGEEVAGLKEECAQLQKALEKSEFQREEL----KAKQVSLTQEKNDLILQLQAEQ 907

Query: 608  ILLEELQQGLSQAKRDVQEQMAVLMQSREQVS---EELVRLQKDNDSLQGKHSLHVSLQQ 664
              L            +V+EQ   L++S+ Q+    +EL    ++ + +  + +      +
Sbjct: 908  ETLA-----------NVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLE 956

Query: 665  AEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQI----QAEQCLK 720
             E F L    + L  +++K  ++    +   +H  + L  E+ FL E I    +A + ++
Sbjct: 957  DECFELKKEIDDLETMLVKSEKE----KRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQ 1012

Query: 721  ENLEETLQLEIENCKEEIASISSLKAELER------------------IKVEKGQLESTL 762
            E  ++TL  ++   +E+++S+S    +LE+                   + E  +LE  L
Sbjct: 1013 EAHQQTLD-DLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNL 1071

Query: 763  REKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFV 822
            +   + +E+L+  +  L E+L+K+    + +   +  EK    +LQ  +   +++Q    
Sbjct: 1072 KLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTV---KELQTQIK 1128

Query: 823  KLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQ 858
             L + L+   ER  +A  +ER RA L    L D+N+
Sbjct: 1129 DLKEKLEA--ERTTRA-KMERERADLTQ-DLADLNE 1160


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  103 bits (258), Expect = 5e-22
 Identities = 190/901 (21%), Positives = 398/901 (44%), Gaps = 116/901 (12%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ------ 60
            +S+  +  +Q+VA+L+    +  R ++QL+++         +L   K++  ++Q      
Sbjct: 444  SSEKLMDKEQQVADLQ---LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST 500

Query: 61   NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV 120
             A L+ AQ+DL  +  Q+ +   +++N++A+   S+    E I  ++++  +  A +QA 
Sbjct: 501  TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK----ENISLLEKEREDLYAKIQAG 556

Query: 121  MKET--VRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
              ET  +   + + H   EQ      + +  +E          S  Q +ENL +++++ +
Sbjct: 557  EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSE----------SHKQAQENLHDQVQEQK 606

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEAS-KVK-ELNHYLEAEKSC-RTDLE 235
                  +  V+ +E  +  L  +L E+++K+ +L+   K K EL    EA K+  R DL+
Sbjct: 607  AHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQ 666

Query: 236  MYVAVLNTQKSVLQEDAEKLRK---ELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQR 292
             +   L+T ++ LQ+  ++L K   +L +V   L+ +++  +QL+   ++  +++L  ++
Sbjct: 667  NH---LDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ 723

Query: 293  LLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCAL 352
                         T E   Q+++L+    E      +   K+    D++++ ++     L
Sbjct: 724  K------------TEELEGQIKKLEADSLE------VKASKEQALQDLQQQRQLNTDLEL 765

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
               E S QL  E+E + STR  +      L     +   +      ++     Q  ++L 
Sbjct: 766  RATELSKQLEMEKEIVSSTRLDLQKKSEAL-----ESIKQKLTKQEEEKQILKQDFETLS 820

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQ 472
                +Q + L  N    +   L +           +S   D  S  S  + +     + +
Sbjct: 821  QETKIQHEELN-NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 879

Query: 473  ERAIKAMTPEQEETASLLSSVTQ-GMESAYVSPSGYRLVSETE----------WNLLQKE 521
             +  KA   + E+T   L    Q  ME+        +   E E           N +Q++
Sbjct: 880  NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939

Query: 522  VHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQEL 581
            +  A N L +        E+QLQG  I E +   + KK Q+   Q   +L+  +  K EL
Sbjct: 940  LIQAQNTLKQN----EKEEQQLQG-NINELKQSSEQKKKQIEALQG--ELKIAVLQKTEL 992

Query: 582  EDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQ---V 638
            E+ ++Q    ++ +++A   +    +   E+ Q+   Q + D   + + L+ +R+    V
Sbjct: 993  ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052

Query: 639  SEELVRLQKD-----------NDSLQGKHSLHVSLQQ---AEDFILPDTTEALRELV--- 681
             E+L   Q+D           N  +Q   +   +L+Q    ++  L +  +AL+++    
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112

Query: 682  -LKYREDIINVRTAADHVEE---KLKAEILFLKEQIQAE--QCLKE--NLEETLQLEIEN 733
             LK +E ++N ++    +EE   + + EI  L E++++   + +KE  NL++  QL I+ 
Sbjct: 1113 SLKEKE-LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171

Query: 734  CKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATV 793
              E      SLKA +E+ K  +  L+  ++++ ++L+     K  +E++ K  +  K   
Sbjct: 1172 KLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELK-----KEFIEKEAKLHSEIKEKE 1226

Query: 794  EQLMFEEKNKAQRLQTELDVSEQ---VQRDFVKLSQTLQVQLERIRQADSLERIRAILND 850
              +   E+N+A+       ++E    V++++ + SQ    +LE  +Q D L    A+L  
Sbjct: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEW-QSSQRRVSELE--KQTDDLRGEIAVLEA 1283

Query: 851  T 851
            T
Sbjct: 1284 T 1284



 Score =  100 bits (249), Expect = 6e-21
 Identities = 182/879 (20%), Positives = 367/879 (41%), Gaps = 95/879 (10%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYL---AKEEDLKRQNAVLQAAQDDL 71
            +Q   +LE+ + E   +++ ++   +QK    ++L     A E  L R +  L    +  
Sbjct: 315  EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
              L+ +L E + + +++KA     +  ++E  ++   Q + E+  L + + ET R    +
Sbjct: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREEK-EQHGLQLQSEINQLHSKLLETERQLG-E 432

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEE--------ENLENEMKKAQEDAE- 182
             H RL+++R   ++     E+++ADL+ +LS  +E+          L++++ K ++  + 
Sbjct: 433  AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492

Query: 183  ----------KLRSVVMPMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSC 230
                      KLR     +E+ +  + DK    + KI+ LEA   K KE    LE E   
Sbjct: 493  QQALQQSTTAKLREAQNDLEQVLRQIGDK----DQKIQNLEALLQKSKENISLLEKE--- 545

Query: 231  RTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLES 290
            R DL   +     + +VL +  EK      +V  L E+ + Q    K   +  +DQ  E 
Sbjct: 546  REDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQ 605

Query: 291  QRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVC 350
            +  L     R+  + TS     V EL  +         LN+ K+ K + ++ +IK     
Sbjct: 606  KAHLRAAQDRVLSLETS-----VNELNSQ---------LNESKE-KVSQLDIQIKAKTEL 650

Query: 351  ALTQEES-SAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTD 409
             L+ E + +AQ ++ + HLD+ + ++      L        +K    + +     A+  D
Sbjct: 651  LLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL--------NKITTQLDQV---TAKLQD 699

Query: 410  SLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQ-MPSGFML 468
                   L+S    Y  K  S     E   G +   ++ S     +   +LQ +     L
Sbjct: 700  KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL 759

Query: 469  TKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNK 528
              D E     ++ + E    ++SS    ++            SE   ++ QK       K
Sbjct: 760  NTDLELRATELSKQLEMEKEIVSSTRLDLQKK----------SEALESIKQKLTKQEEEK 809

Query: 529  LGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQS 588
               + D    +E   Q  +IQ  E  ++++     L++   + E  M +   ++D + + 
Sbjct: 810  QILKQD----FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 865

Query: 589  SEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVR-LQK 647
            S+   +  S      Q  +  + +L++   + K     Q+ V M++  +  +EL + L+K
Sbjct: 866  SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH----QLQVQMENTLKEQKELKKSLEK 921

Query: 648  DNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEIL 707
            + ++    H L + L   ++ ++      L++   + ++   N+       E+K K +I 
Sbjct: 922  EKEA---SHQLKLELNSMQEQLI-QAQNTLKQNEKEEQQLQGNINELKQSSEQK-KKQIE 976

Query: 708  FLKEQIQAEQCLKENLEETLQLEIENCKEEIAS----ISSLKAELERIKVEKGQLESTLR 763
             L+ +++     K  LE  LQ ++    +E+A+    IS L+   E+ +    QL+S   
Sbjct: 977  ALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFY 1036

Query: 764  EKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVK 823
             +  +L + ++   S+EE+L        +    +  +    Q L+T     EQ   D  K
Sbjct: 1037 GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ---DSAK 1093

Query: 824  LSQTLQVQ---LERIRQADSLERIRAILNDTKLTDINQL 859
              Q LQ +   L+ I++  SL+    +   +KL +I ++
Sbjct: 1094 KEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEI 1132



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 196/958 (20%), Positives = 401/958 (41%), Gaps = 173/958 (18%)

Query: 5   GPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVL 64
           G   + +++L++    L +   + L+A  + E+ ++++  K  E Y   ++   + + ++
Sbjct: 71  GHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLV 130

Query: 65  QAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQE---AIDEVKRQWREE-------- 113
             +  +L  L  QL EAQ E  NIK +  + E    +    I ++K ++ EE        
Sbjct: 131 TDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAE 190

Query: 114 -----------------------------VASLQAVMKETVRDYEHQFHLRLEQERTQ-- 142
                                        +  +  + KE V+      ++ LE+ER    
Sbjct: 191 QKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEK 250

Query: 143 --------WAQYRESAEREIADLRRRLSEG--------QEEENLENEMKKAQEDAEKLRS 186
                    +QY  S+E  I+ LR  L++G        QE + L++ + +  +  + L  
Sbjct: 251 LKDECKKLQSQY-ASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE 309

Query: 187 VVMPMEKEIAALKDKLTEAEDKIKELEAS-KVKELNHYLEAEKSCRTDLEMYVAVLNTQK 245
            ++  E++   L++K  E     K ++A+   K+L+   +  +S  +  E  +  ++ + 
Sbjct: 310 NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLD--CQQLQSRLSASETSLHRIHVEL 367

Query: 246 SVLQEDAEKLRKELHEV----CHL---------LEQERQQHN-QLKHTWQKANDQFLESQ 291
           S   E  +KL++EL EV     HL           +E++QH  QL+    + + + LE++
Sbjct: 368 SEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427

Query: 292 RLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCA 351
           R L     R++      QL   + + K+ Q  D Q +L++ ++  K  V    ++     
Sbjct: 428 RQLGEAHGRLK---EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLD 484

Query: 352 LTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSL 411
            T+++   Q + ++      R + + L+  +L   GD          KD  ++ Q+ ++L
Sbjct: 485 KTKQQHQEQQALQQSTTAKLREAQNDLEQ-VLRQIGD----------KD--QKIQNLEAL 531

Query: 412 GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
                LQ        K+K   +L E +   L       E  +TA L  L           
Sbjct: 532 -----LQ--------KSKENISLLEKEREDLYAKIQAGEG-ETAVLNQL----------- 566

Query: 472 QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGR 531
                      QE+  +L   VTQ  E        ++   E     L  +V      L  
Sbjct: 567 -----------QEKNHTLQEQVTQLTEKLKNQSESHKQAQEN----LHDQVQEQKAHLRA 611

Query: 532 RCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMK--DKQELEDF 584
             D   + E  +  +  Q  E++++V +L + ++   + L      KT +  D Q   D 
Sbjct: 612 AQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDT 671

Query: 585 IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAK---RDVQEQMAVLMQSREQVSEE 641
            + + +D   +++ +  +       L++ Q+  SQ +   ++ +E+   L Q  E++  +
Sbjct: 672 AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ 731

Query: 642 LVRLQKDNDSLQGKHSLHVSLQQAEDFILPDT------TEALRELVLKYREDIINVRTAA 695
           + +L+   DSL+ K S   +LQ  +     +T      TE  ++L ++ +E + + R   
Sbjct: 732 IKKLEA--DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME-KEIVSSTRLDL 788

Query: 696 DHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS-ISSLKAELERIKVE 754
               E L++    L +Q + +Q LK++  ETL  E +   EE+ + I +   EL+++K+E
Sbjct: 789 QKKSEALESIKQKLTKQEEEKQILKQDF-ETLSQETKIQHEELNNRIQTTVTELQKVKME 847

Query: 755 KGQLE---STLREK-SQQLESLQEIKISLEEQLKKETAA---------------KATVEQ 795
           K  L    ST+++K S+  +SL+  K   E++ +K  AA               +  +E 
Sbjct: 848 KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907

Query: 796 LMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE-RIRAILNDTK 852
            + E+K   + L+ E + S Q++ +   + + L      ++Q +  E +++  +N+ K
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 145/693 (20%), Positives = 299/693 (43%), Gaps = 96/693 (13%)

Query: 12   VSLQQRVAELE----KINAEFLR---AQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVL 64
            +SL+Q+  ELE    K+ A+ L    +++Q  Q+  Q+R    +L L   E  K+    L
Sbjct: 719  LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ----L 774

Query: 65   QAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKET 124
            +  ++ +   R  L +    +E+IK      + TKQE   ++ +Q  E ++    +  E 
Sbjct: 775  EMEKEIVSSTRLDLQKKSEALESIK-----QKLTKQEEEKQILKQDFETLSQETKIQHEE 829

Query: 125  VRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKL 184
            + +        L++ + +    +E+   E++ ++ +LS+    ++L+N   + +++ +K 
Sbjct: 830  LNNRIQTTVTELQKVKME----KEALMTELSTVKDKLSK--VSDSLKNSKSEFEKENQKG 883

Query: 185  RSVVMPMEKEIAALKDKL-TEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNT 243
            ++ ++ +EK    LK +L  + E+ +KE      KEL   LE EK     L++ +  +  
Sbjct: 884  KAAILDLEKTCKELKHQLQVQMENTLKE-----QKELKKSLEKEKEASHQLKLELNSMQE 938

Query: 244  QKSVLQEDAEKLRKELHEVCHLLEQERQQH-NQLKHTWQKANDQFLESQRLLMRDMQRME 302
            Q    Q   ++  KE        EQ+ Q + N+LK + ++   Q    Q  L        
Sbjct: 939  QLIQAQNTLKQNEKE--------EQQLQGNINELKQSSEQKKKQIEALQGEL-------- 982

Query: 303  IVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLS 362
                     ++  L+K + E+  QQ+L +      A+ +E+I +        +E+  QL 
Sbjct: 983  ---------KIAVLQKTELENKLQQQLTQAAQELAAE-KEKISVLQNNYEKSQETFKQLQ 1032

Query: 363  NE----EEHLDSTRGSVHSLDAGLLLPSGDPFSK-----SDNDMFKDGLRRAQST---DS 410
            ++    E  L +TR  + S++  L L   D  S      + N + ++ L+ A++T   DS
Sbjct: 1033 SDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE-LKTAKATLEQDS 1091

Query: 411  LGTSGSLQS--KALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFML 468
                  LQ   KAL    K KS           L   + V+E    A +  ++      +
Sbjct: 1092 AKKEQQLQERCKALQDIQKEKS-----------LKEKELVNEKSKLAEIEEIKCRQEKEI 1140

Query: 469  TKDQERAIKAMTPEQEETASLLSS----VTQGMESAYVSPSGYRLVSETEWN--LLQKEV 522
            TK  E          +E  +L  +    + Q +E    + S    V + + N  +L+ +V
Sbjct: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV 1200

Query: 523  HNAGNKLGRR-CDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQL---EKTMKDK 578
                 +L +   +  +    +++  ++   +  +   KL + +   N+ L   +K  +  
Sbjct: 1201 KKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS 1260

Query: 579  QELEDFIKQSSEDSSHQISALVLRAQASE----ILLEELQQGLSQAKRDVQEQMAVLMQS 634
            Q     +++ ++D   +I+ L    Q ++     LLE   +G  + ++ +Q ++  L + 
Sbjct: 1261 QRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEK-LQTKVLELQRK 1319

Query: 635  REQVSEELVRLQKDNDSLQGKHSLHVSLQQAED 667
             +  +  +  L ++N SLQ KH+  ++ + AED
Sbjct: 1320 LDNTTAAVQELGRENQSLQIKHTQALNRKWAED 1352



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 158/839 (18%), Positives = 341/839 (40%), Gaps = 105/839 (12%)

Query: 20   ELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLW 79
            +L++ N        QL ++   +    K+      + ++ Q A L+AAQD +  L T + 
Sbjct: 565  QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624

Query: 80   EAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASL-QAVMKETVRDYEHQFHLRLEQ 138
            E  +++           N  +E + ++  Q + +   L  A   +T +  + Q HL   Q
Sbjct: 625  ELNSQL-----------NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ 673

Query: 139  ERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAAL 198
               Q        ++E+  +  +L +      +  +++  QE   +L S +   +++  +L
Sbjct: 674  NALQ------DKQQELNKITTQLDQ------VTAKLQDKQEHCSQLESHLKEYKEKYLSL 721

Query: 199  KDKLTEAEDKIKELEASKVK------ELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDA 252
            + K  E E +IK+LEA  ++      +    L+ ++   TDLE+    L+ Q  + +E  
Sbjct: 722  EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781

Query: 253  EKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQF--LESQRLLMRDMQRMEIVLTSEQL 310
               R +L +    LE  +Q+  + +   Q     F  L  +  +  +     I  T  +L
Sbjct: 782  SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTEL 841

Query: 311  RQVEELKKKDQED-----DEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNE- 364
            ++V+  K+    +     D+  +++    + K++ E+E +      L  E++  +L ++ 
Sbjct: 842  QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL 901

Query: 365  EEHLDSTRGSVHSLDAGLLLPSGDPFS-KSDNDMFKDGLRRAQSTDSLGTSGSLQSKALG 423
            +  +++T      L   L          K + +  ++ L +AQ+T  L  +   + +  G
Sbjct: 902  QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT--LKQNEKEEQQLQG 959

Query: 424  YNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMP-----SGFMLTKDQERAIKA 478
               + K +    +     L G   ++    T     LQ             K++   ++ 
Sbjct: 960  NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019

Query: 479  MTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSN 538
               + +ET   L S   G ES  ++        E + +L Q+++ +  N++G       N
Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIG-------N 1072

Query: 539  YEKQLQGIQIQEAET-RDQVKKLQLMLRQAND----QLEKTMKDKQ---------ELEDF 584
              K +Q ++  +A   +D  KK Q +  +       Q EK++K+K+         E+E+ 
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEI 1132

Query: 585  --------IKQSSEDSSHQISAL---VLRAQASEILLE---ELQQGLSQAKRDVQEQMAV 630
                     K + E  SH++ ++        A ++L++   ELQ      K  V+++   
Sbjct: 1133 KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN 1192

Query: 631  LMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAE---------DFILPDTTEALRELV 681
                ++QV +E   L+K+    + K  LH  +++ E         +  L     AL E +
Sbjct: 1193 QQILKDQVKKEEEELKKEFIEKEAK--LHSEIKEKEVGMKKHEENEAKLTMQITALNENL 1250

Query: 682  LKYREDIINVRTAADHVEEK---LKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEI 738
               +++  + +     +E++   L+ EI  L+  +Q  Q  +  L       +E C +  
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL-------LERCLKGE 1303

Query: 739  ASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLM 797
              I  L+ ++  ++ +     + ++E  ++ +SLQ   I   + L ++ A    V+  M
Sbjct: 1304 GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ---IKHTQALNRKWAEDNEVQNCM 1359



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 77/386 (19%), Positives = 171/386 (44%), Gaps = 60/386 (15%)

Query: 517 LLQKEVHNAGNKLGRRCDMCSNYEKQL---QGIQIQEAETRDQVKKLQLMLRQANDQLEK 573
           LL++EV +    L          +K+L   QG+Q QEA+    V      L+    QLE+
Sbjct: 87  LLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEE 146

Query: 574 TMKDK---QELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAV 630
              +    ++++D  +Q +   + +I+ +  +      L E  +Q +++   ++ ++  V
Sbjct: 147 AQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATV 206

Query: 631 LMQSREQV------------SEELVRLQK--DNDSLQGKH-------------SLHVSLQ 663
           +   + ++             +ELV++Q   DN +L+ +              S + S +
Sbjct: 207 IQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE 266

Query: 664 QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEK--------LKAEILF--LKEQI 713
                +  +  +  +E+ + Y +++  ++++ + + +K        LK E  +  L+E+ 
Sbjct: 267 ATISQLRSELAKGPQEVAV-YVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325

Query: 714 QAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQ 773
             E   K+N++ TL  +  +C++  + +S+ +  L RI VE       L EK    E+ Q
Sbjct: 326 NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-------LSEKG---EATQ 375

Query: 774 EIKISLEEQLKKETAAKATVEQLMFEEKNKAQ---RLQTELDVSEQVQRDFVKLSQTLQV 830
           ++K  L E   K    KA  +QL  + + K Q   +LQ+E++   Q+    ++  + L  
Sbjct: 376 KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN---QLHSKLLETERQLGE 432

Query: 831 QLERIRQADSLERIRAILNDTKLTDI 856
              R+++   L   + +  + ++ D+
Sbjct: 433 AHGRLKEQRQLSSEKLMDKEQQVADL 458


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  103 bits (257), Expect = 7e-22
 Identities = 171/886 (19%), Positives = 365/886 (41%), Gaps = 99/886 (11%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQ---QLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQ 65
            Q D  L+++  E+  + ++    Q    QL+++  + +A+ +EL    EE+++ + A   
Sbjct: 1081 QLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL----EEEIEAERASRA 1136

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAI--ATVSENTKQEAIDEVKRQWREEVASLQAVMKE 123
             A+     L  +L E    +E       A +  N K+EA  +  R+  EE          
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEK 183
            T+R         L ++     + ++  E+E ++++       E ++L + ++   +    
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK------MEIDDLASNVETVSKAKGN 1250

Query: 184  LRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNT 243
            L  +   +E +++ LK K  E +  I +L A + +      E  +    + E  V+ L+ 
Sbjct: 1251 LEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQL-DEKEALVSQLSR 1309

Query: 244  QKSVLQEDAEKLRKELHE-------VCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMR 296
             K    +  E+L+++L E       + H L+  R   + L+  +++  +   E QR L +
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

Query: 297  ---DMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
               ++ +      ++ +++ EEL++  ++    QRL   ++H +A       +   CA +
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKK--LAQRLQAAEEHVEA-------VNAKCA-S 1419

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
             E++  +L NE E L       ++  A L     D   ++ + +  +  ++ + T +   
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAAL-----DKKQRNFDKILAEWKQKCEETHAELE 1474

Query: 414  SGSLQSKALGYN-YKAKSA--GNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTK 470
            +   ++++LG   +K K+A   +LD+ +       +   E  D       Q+  G     
Sbjct: 1475 ASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE----QIAEGGKRIH 1530

Query: 471  DQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLG 530
            + E+  K +  E+ E  + L      +E       G  L  + E N ++ EV     +  
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHE----EGKILRIQLELNQVKSEVDRKIAEKD 1586

Query: 531  RRCDMCS-NYEKQLQGIQIQ-EAETRDQ-------------VKKLQLMLRQANDQLEKTM 575
               D    N+ + ++ +Q   +AE R +             + ++++ L  AN    + +
Sbjct: 1587 EEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646

Query: 576  KDKQELEDFIK----------QSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQ 625
            ++ +  +  +K          +S ED   Q++ +  RA   +  +EEL+  L Q +R   
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER--- 1703

Query: 626  EQMAVLMQSREQVSEELVRLQKDNDSL-QGKHSLHVSLQQAEDFILPDTTEALRELVLKY 684
                +  Q     SE +  L   N SL   K  L   + Q +   + D  +  R    K 
Sbjct: 1704 -SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQG-EMEDILQEARNAEEKA 1761

Query: 685  REDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---NLEETLQLEIENCKEEIASI 741
            ++ I +    A+ ++++        + +   EQ +K+    L+E  QL ++  K++I  +
Sbjct: 1762 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL 1821

Query: 742  SSLKAELERIKVEKGQLESTLREKSQQLESL-------QEIKISLEEQLKKETAAKATVE 794
             +   ELE      G++ES  +  ++ ++ L       +E+    EE  K     +  V+
Sbjct: 1822 EARVRELE------GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVD 1875

Query: 795  QLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS 840
            +L  + K+  ++ +   + S      F KL   L+   ER   A+S
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAES 1921



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 193/927 (20%), Positives = 378/927 (40%), Gaps = 148/927 (15%)

Query: 16   QRVAELEKINAEFLRAQQQLEQEFNQKRAKFK--ELYLAKEEDLKR--QNAVLQAAQDDL 71
            +R  + E+INAE    +++LE E ++ +      EL LAK E  K   +N V    ++  
Sbjct: 930  ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 989

Query: 72   GHLRT---------QLWEA-QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVM 121
            G   T          L EA Q  +++++A     E  K   + + K +  ++V  L+  +
Sbjct: 990  GLDETIAKLTKEKKALQEAHQQTLDDLQA-----EEDKVNTLTKAKIKLEQQVDDLEGSL 1044

Query: 122  KETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDA 181
            ++     E +  + LE+ + +     + A+  I D+        E++ L+ ++KK + + 
Sbjct: 1045 EQ-----EKKLRMDLERAKRKLEGDLKLAQESIMDIEN------EKQQLDEKLKKKEFEI 1093

Query: 182  EKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVL 241
              L+S +    ++  AL  +L   + KIKEL+A +++EL   +EAE++ R   E      
Sbjct: 1094 SNLQSKI----EDEQALGIQL---QKKIKELQA-RIEELEEEIEAERASRAKAE------ 1139

Query: 242  NTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM 301
              Q+S L  + E++ + L E       + + +       +K   +F + +R L     + 
Sbjct: 1140 -KQRSDLSRELEEISERLEEAGGATSAQIEMN-------KKREAEFQKMRRDLEEATLQH 1191

Query: 302  EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEI---------------KI 346
            E    + + +  + + +  ++ D  QR+ ++ + +K++++ EI                +
Sbjct: 1192 EATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL 1251

Query: 347  PVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDA--GLLLPSGDPFSKSDNDMFKDGLRR 404
              +C   +++ S   S EEE     +  ++ L A  G L      FS+  ++  K+ L  
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQ----QRLINDLTAQRGRLQTESGEFSRQLDE--KEALVS 1305

Query: 405  AQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS 464
              S      +  ++        + K+   L  +        D + E ++       ++  
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365

Query: 465  GF---------MLTKDQERAIKAMTPEQEETASLLSSVTQGMES---------AYVSPSG 506
                         TK +  AI+  T E EE    L+   Q  E          A +  + 
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 507  YRLVSETEWNLLQKEVHNAG----NKLGRRCD--------MCSNYEKQLQGIQIQEAETR 554
             RL +E E  +L  E  NA     +K  R  D         C     +L+  Q +     
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484

Query: 555  DQVKKLQLMLRQANDQLEKTMKD----KQELEDFIKQSSEDSS--HQISALVLRAQAS-- 606
             ++ K++    ++ DQLE   ++    +QE+ D  +Q +E     H++  +  + +    
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544

Query: 607  --EILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV-SLQ 663
              +  LEE +  L   +  +      L Q + +V  ++    ++ D L+  H   V S+Q
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604

Query: 664  QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEIL--------FLKE-QIQ 714
               D  +    +A+R L  K   D+  +    +H   ++ AE L         LK+ QI 
Sbjct: 1605 STLDAEIRSRNDAIR-LKKKMEGDLNEMEIQLNHA-NRMAAEALRNYRNTQGILKDTQIH 1662

Query: 715  AEQCLK--ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESL 772
             +  L+  E+L+E L +         A I  L+A LE+ +  +   E  L + S++++ L
Sbjct: 1663 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1722

Query: 773  QEIKISLEEQLKK-ET---AAKATVEQLMFEEKN--------------KAQRLQTELDVS 814
                 SL    KK ET     +  +E ++ E +N               A+ L+ E D S
Sbjct: 1723 HTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTS 1782

Query: 815  EQVQRDFVKLSQTLQVQLERIRQADSL 841
              ++R    + QT++    R+ +A+ L
Sbjct: 1783 AHLERMKKNMEQTVKDLQLRLDEAEQL 1809



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 161/828 (19%), Positives = 345/828 (41%), Gaps = 76/828 (9%)

Query: 57   LKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEA-IDEVKRQWREEVA 115
            ++R+ A+     +    +  + W        IK +   +E  K+ A + E  ++ ++E+A
Sbjct: 811  VERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELA 870

Query: 116  SLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEE-NLENEM 174
              +A  KE     E +    L+++     Q +  AE  +AD   R  +  + +  LE ++
Sbjct: 871  KSEAKRKEL----EEKMVTLLKEKNDLQLQVQAEAEG-LADAEERCDQLIKTKIQLEAKI 925

Query: 175  KKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE--ASKVKELNHYLEAEKSCRT 232
            K+  E AE    +   +  +   L+D+ +E +  I +LE   +KV++  H  E +    T
Sbjct: 926  KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 985

Query: 233  D----LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQF- 287
            +    L+  +A L  +K  LQE  ++   +       L+ E  + N L     K   Q  
Sbjct: 986  EEMAGLDETIAKLTKEKKALQEAHQQTLDD-------LQAEEDKVNTLTKAKIKLEQQVD 1038

Query: 288  -----LESQRLLMRDMQRM------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHK 336
                 LE ++ L  D++R       ++ L  E +  +E   +K Q D++ ++      + 
Sbjct: 1039 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE--NEKQQLDEKLKKKEFEISNL 1096

Query: 337  KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDND 396
            ++ +E+E  + +      +E  A++   EE +++ R S    +            K  +D
Sbjct: 1097 QSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE------------KQRSD 1144

Query: 397  MFKDGLRRAQSTDSLGTSGSLQSKALGYNYK-----AKSAGNLDESDFGPLVGADSVSEN 451
            + ++     + ++ L  +G   S  +  N K      K   +L+E+       A ++ + 
Sbjct: 1145 LSRE---LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1201

Query: 452  F--DTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQ---GMESAYVSPSG 506
                 A LG  Q+ +   + +  E+    M  E ++ AS + +V++    +E    +   
Sbjct: 1202 HADSVAELGE-QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLED 1260

Query: 507  YRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQ 566
                 +++    Q+ +++   + GR       + +QL     ++     Q+ + +    Q
Sbjct: 1261 QLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD----EKEALVSQLSRGKQAFTQ 1316

Query: 567  ANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQE 626
              ++L++ ++++ + ++ +  + + S H    L  + +  +    ELQ+ LS+A  +V +
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376

Query: 627  QMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYRE 686
                      Q +EEL   +K           HV    A+   L  T + L+  V     
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436

Query: 687  DIINVRTAADHVE------EKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCK----E 736
            D+     A   ++      +K+ AE     E+  AE    +    +L  E+   K    E
Sbjct: 1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496

Query: 737  EIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQL 796
             +  + +LK E + ++ E   L   + E  +++  L++IK  +E++  +  AA    E  
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556

Query: 797  MFEEKNKAQRLQTELD-VSEQVQRDFVKLSQTL-QVQLERIRQADSLE 842
            +  E+ K  R+Q EL+ V  +V R   +  + + Q++   IR  +S++
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 73/349 (20%), Positives = 163/349 (46%), Gaps = 48/349 (13%)

Query: 548  IQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELED----FIKQSSE------------- 590
            ++ AET  ++  ++   ++  D+L K+   ++ELE+     +K+ ++             
Sbjct: 846  LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905

Query: 591  DSSHQISALV-----LRAQASEIL-----LEELQQGLSQAKRDVQEQMAVLMQSREQVSE 640
            D+  +   L+     L A+  E+       EE+   L+  KR ++++ + L +  + +  
Sbjct: 906  DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965

Query: 641  ELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEE 700
             L +++K+  + + K           D  +   T+  + L   +++ + +++   D V  
Sbjct: 966  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025

Query: 701  KLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAE-LERIKVEKGQLE 759
              KA+I   ++    E  L++  E+ L++++E  K ++     L  E +  I+ EK QL+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQ--EKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD 1083

Query: 760  STLREKSQQLESLQEIKISLEEQL-----KKETAAKATVEQLMFE-EKNKAQRLQTELDV 813
              L++K  ++ +LQ  KI  E+ L     KK    +A +E+L  E E  +A R + E   
Sbjct: 1084 EKLKKKEFEISNLQS-KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142

Query: 814  SEQVQRDFVKLSQTL---------QVQLERIRQADSLERIRAILNDTKL 853
            S+ + R+  ++S+ L         Q+++ + R+A+  +++R  L +  L
Sbjct: 1143 SD-LSRELEEISERLEEAGGATSAQIEMNKKREAE-FQKMRRDLEEATL 1189


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  103 bits (257), Expect = 7e-22
 Identities = 171/886 (19%), Positives = 365/886 (41%), Gaps = 99/886 (11%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQ---QLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQ 65
            Q D  L+++  E+  + ++    Q    QL+++  + +A+ +EL    EE+++ + A   
Sbjct: 1081 QLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL----EEEIEAERASRA 1136

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAI--ATVSENTKQEAIDEVKRQWREEVASLQAVMKE 123
             A+     L  +L E    +E       A +  N K+EA  +  R+  EE          
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEK 183
            T+R         L ++     + ++  E+E ++++       E ++L + ++   +    
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK------MEIDDLASNVETVSKAKGN 1250

Query: 184  LRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNT 243
            L  +   +E +++ LK K  E +  I +L A + +      E  +    + E  V+ L+ 
Sbjct: 1251 LEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQL-DEKEALVSQLSR 1309

Query: 244  QKSVLQEDAEKLRKELHE-------VCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMR 296
             K    +  E+L+++L E       + H L+  R   + L+  +++  +   E QR L +
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

Query: 297  ---DMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
               ++ +      ++ +++ EEL++  ++    QRL   ++H +A       +   CA +
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKK--LAQRLQAAEEHVEA-------VNAKCA-S 1419

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
             E++  +L NE E L       ++  A L     D   ++ + +  +  ++ + T +   
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAAL-----DKKQRNFDKILAEWKQKCEETHAELE 1474

Query: 414  SGSLQSKALGYN-YKAKSA--GNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTK 470
            +   ++++LG   +K K+A   +LD+ +       +   E  D       Q+  G     
Sbjct: 1475 ASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE----QIAEGGKRIH 1530

Query: 471  DQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLG 530
            + E+  K +  E+ E  + L      +E       G  L  + E N ++ EV     +  
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHE----EGKILRIQLELNQVKSEVDRKIAEKD 1586

Query: 531  RRCDMCS-NYEKQLQGIQIQ-EAETRDQ-------------VKKLQLMLRQANDQLEKTM 575
               D    N+ + ++ +Q   +AE R +             + ++++ L  AN    + +
Sbjct: 1587 EEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646

Query: 576  KDKQELEDFIK----------QSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQ 625
            ++ +  +  +K          +S ED   Q++ +  RA   +  +EEL+  L Q +R   
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER--- 1703

Query: 626  EQMAVLMQSREQVSEELVRLQKDNDSL-QGKHSLHVSLQQAEDFILPDTTEALRELVLKY 684
                +  Q     SE +  L   N SL   K  L   + Q +   + D  +  R    K 
Sbjct: 1704 -SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQG-EMEDILQEARNAEEKA 1761

Query: 685  REDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---NLEETLQLEIENCKEEIASI 741
            ++ I +    A+ ++++        + +   EQ +K+    L+E  QL ++  K++I  +
Sbjct: 1762 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL 1821

Query: 742  SSLKAELERIKVEKGQLESTLREKSQQLESL-------QEIKISLEEQLKKETAAKATVE 794
             +   ELE      G++ES  +  ++ ++ L       +E+    EE  K     +  V+
Sbjct: 1822 EARVRELE------GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVD 1875

Query: 795  QLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS 840
            +L  + K+  ++ +   + S      F KL   L+   ER   A+S
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAES 1921



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 193/927 (20%), Positives = 378/927 (40%), Gaps = 148/927 (15%)

Query: 16   QRVAELEKINAEFLRAQQQLEQEFNQKRAKFK--ELYLAKEEDLKR--QNAVLQAAQDDL 71
            +R  + E+INAE    +++LE E ++ +      EL LAK E  K   +N V    ++  
Sbjct: 930  ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 989

Query: 72   GHLRT---------QLWEA-QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVM 121
            G   T          L EA Q  +++++A     E  K   + + K +  ++V  L+  +
Sbjct: 990  GLDETIAKLTKEKKALQEAHQQTLDDLQA-----EEDKVNTLTKAKIKLEQQVDDLEGSL 1044

Query: 122  KETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDA 181
            ++     E +  + LE+ + +     + A+  I D+        E++ L+ ++KK + + 
Sbjct: 1045 EQ-----EKKLRMDLERAKRKLEGDLKLAQESIMDIEN------EKQQLDEKLKKKEFEI 1093

Query: 182  EKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVL 241
              L+S +    ++  AL  +L   + KIKEL+A +++EL   +EAE++ R   E      
Sbjct: 1094 SNLQSKI----EDEQALGIQL---QKKIKELQA-RIEELEEEIEAERASRAKAE------ 1139

Query: 242  NTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM 301
              Q+S L  + E++ + L E       + + +       +K   +F + +R L     + 
Sbjct: 1140 -KQRSDLSRELEEISERLEEAGGATSAQIEMN-------KKREAEFQKMRRDLEEATLQH 1191

Query: 302  EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEI---------------KI 346
            E    + + +  + + +  ++ D  QR+ ++ + +K++++ EI                +
Sbjct: 1192 EATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL 1251

Query: 347  PVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDA--GLLLPSGDPFSKSDNDMFKDGLRR 404
              +C   +++ S   S EEE     +  ++ L A  G L      FS+  ++  K+ L  
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQ----QRLINDLTAQRGRLQTESGEFSRQLDE--KEALVS 1305

Query: 405  AQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS 464
              S      +  ++        + K+   L  +        D + E ++       ++  
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365

Query: 465  GF---------MLTKDQERAIKAMTPEQEETASLLSSVTQGMES---------AYVSPSG 506
                         TK +  AI+  T E EE    L+   Q  E          A +  + 
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 507  YRLVSETEWNLLQKEVHNAG----NKLGRRCD--------MCSNYEKQLQGIQIQEAETR 554
             RL +E E  +L  E  NA     +K  R  D         C     +L+  Q +     
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484

Query: 555  DQVKKLQLMLRQANDQLEKTMKD----KQELEDFIKQSSEDSS--HQISALVLRAQAS-- 606
             ++ K++    ++ DQLE   ++    +QE+ D  +Q +E     H++  +  + +    
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544

Query: 607  --EILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV-SLQ 663
              +  LEE +  L   +  +      L Q + +V  ++    ++ D L+  H   V S+Q
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604

Query: 664  QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEIL--------FLKE-QIQ 714
               D  +    +A+R L  K   D+  +    +H   ++ AE L         LK+ QI 
Sbjct: 1605 STLDAEIRSRNDAIR-LKKKMEGDLNEMEIQLNHA-NRMAAEALRNYRNTQGILKDTQIH 1662

Query: 715  AEQCLK--ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESL 772
             +  L+  E+L+E L +         A I  L+A LE+ +  +   E  L + S++++ L
Sbjct: 1663 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1722

Query: 773  QEIKISLEEQLKK-ET---AAKATVEQLMFEEKN--------------KAQRLQTELDVS 814
                 SL    KK ET     +  +E ++ E +N               A+ L+ E D S
Sbjct: 1723 HTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTS 1782

Query: 815  EQVQRDFVKLSQTLQVQLERIRQADSL 841
              ++R    + QT++    R+ +A+ L
Sbjct: 1783 AHLERMKKNMEQTVKDLQLRLDEAEQL 1809



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 161/828 (19%), Positives = 345/828 (41%), Gaps = 76/828 (9%)

Query: 57   LKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEA-IDEVKRQWREEVA 115
            ++R+ A+     +    +  + W        IK +   +E  K+ A + E  ++ ++E+A
Sbjct: 811  VERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELA 870

Query: 116  SLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEE-NLENEM 174
              +A  KE     E +    L+++     Q +  AE  +AD   R  +  + +  LE ++
Sbjct: 871  KSEAKRKEL----EEKMVTLLKEKNDLQLQVQAEAEG-LADAEERCDQLIKTKIQLEAKI 925

Query: 175  KKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE--ASKVKELNHYLEAEKSCRT 232
            K+  E AE    +   +  +   L+D+ +E +  I +LE   +KV++  H  E +    T
Sbjct: 926  KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 985

Query: 233  D----LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQF- 287
            +    L+  +A L  +K  LQE  ++   +       L+ E  + N L     K   Q  
Sbjct: 986  EEMAGLDETIAKLTKEKKALQEAHQQTLDD-------LQAEEDKVNTLTKAKIKLEQQVD 1038

Query: 288  -----LESQRLLMRDMQRM------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHK 336
                 LE ++ L  D++R       ++ L  E +  +E   +K Q D++ ++      + 
Sbjct: 1039 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE--NEKQQLDEKLKKKEFEISNL 1096

Query: 337  KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDND 396
            ++ +E+E  + +      +E  A++   EE +++ R S    +            K  +D
Sbjct: 1097 QSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE------------KQRSD 1144

Query: 397  MFKDGLRRAQSTDSLGTSGSLQSKALGYNYK-----AKSAGNLDESDFGPLVGADSVSEN 451
            + ++     + ++ L  +G   S  +  N K      K   +L+E+       A ++ + 
Sbjct: 1145 LSRE---LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1201

Query: 452  F--DTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQ---GMESAYVSPSG 506
                 A LG  Q+ +   + +  E+    M  E ++ AS + +V++    +E    +   
Sbjct: 1202 HADSVAELGE-QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLED 1260

Query: 507  YRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQ 566
                 +++    Q+ +++   + GR       + +QL     ++     Q+ + +    Q
Sbjct: 1261 QLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD----EKEALVSQLSRGKQAFTQ 1316

Query: 567  ANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQE 626
              ++L++ ++++ + ++ +  + + S H    L  + +  +    ELQ+ LS+A  +V +
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376

Query: 627  QMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYRE 686
                      Q +EEL   +K           HV    A+   L  T + L+  V     
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436

Query: 687  DIINVRTAADHVE------EKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCK----E 736
            D+     A   ++      +K+ AE     E+  AE    +    +L  E+   K    E
Sbjct: 1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496

Query: 737  EIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQL 796
             +  + +LK E + ++ E   L   + E  +++  L++IK  +E++  +  AA    E  
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556

Query: 797  MFEEKNKAQRLQTELD-VSEQVQRDFVKLSQTL-QVQLERIRQADSLE 842
            +  E+ K  R+Q EL+ V  +V R   +  + + Q++   IR  +S++
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 73/349 (20%), Positives = 163/349 (46%), Gaps = 48/349 (13%)

Query: 548  IQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELED----FIKQSSE------------- 590
            ++ AET  ++  ++   ++  D+L K+   ++ELE+     +K+ ++             
Sbjct: 846  LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905

Query: 591  DSSHQISALV-----LRAQASEIL-----LEELQQGLSQAKRDVQEQMAVLMQSREQVSE 640
            D+  +   L+     L A+  E+       EE+   L+  KR ++++ + L +  + +  
Sbjct: 906  DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965

Query: 641  ELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEE 700
             L +++K+  + + K           D  +   T+  + L   +++ + +++   D V  
Sbjct: 966  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025

Query: 701  KLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAE-LERIKVEKGQLE 759
              KA+I   ++    E  L++  E+ L++++E  K ++     L  E +  I+ EK QL+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQ--EKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD 1083

Query: 760  STLREKSQQLESLQEIKISLEEQL-----KKETAAKATVEQLMFE-EKNKAQRLQTELDV 813
              L++K  ++ +LQ  KI  E+ L     KK    +A +E+L  E E  +A R + E   
Sbjct: 1084 EKLKKKEFEISNLQS-KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142

Query: 814  SEQVQRDFVKLSQTL---------QVQLERIRQADSLERIRAILNDTKL 853
            S+ + R+  ++S+ L         Q+++ + R+A+  +++R  L +  L
Sbjct: 1143 SD-LSRELEEISERLEEAGGATSAQIEMNKKREAE-FQKMRRDLEEATL 1189


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  102 bits (253), Expect = 2e-21
 Identities = 163/870 (18%), Positives = 361/870 (41%), Gaps = 103/870 (11%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQ---QQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQ 65
            Q D  L+++  E+  + ++    Q    QL+++  + +A+ +EL    EE+++ + A   
Sbjct: 1079 QLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEEL----EEEIEAERASRA 1134

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAI--ATVSENTKQEAIDEVKRQWREEVASLQAVMKE 123
             A+     L  +L E    +E       A +  N K+EA  +  R+  EE          
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEK 183
            T+R         L ++     + ++  E+E ++++       E ++L + M+   +    
Sbjct: 1195 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK------MEIDDLASNMETVSKAKGN 1248

Query: 184  LRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNT 243
            L  +   +E +++ +K K  E +  I +L A + +      E  +    + +  V+ L+ 
Sbjct: 1249 LEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQL-DEKDTLVSQLSR 1307

Query: 244  QKSVLQEDAEKLRKELHE-------VCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMR 296
             K    +  E+L+++L E       + H L+  R   + L+  +++  +   E QR + +
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367

Query: 297  DMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEE 356
                +    T  +   +       Q  +E +   K+   +  D EE ++       + E+
Sbjct: 1368 ANSEVAQWRTKYETDAI-------QRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420

Query: 357  SSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGS 416
            +  +L NE E L       ++  A L     D   ++ + +  +  ++ + T +   +  
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACAAL-----DKKQRNFDKILAEWKQKCEETHAELEASQ 1475

Query: 417  LQSKALGYN-YKAKSA--GNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQE 473
             +S++L    +K K+A   +LD+ +       +   E  D       Q+  G     + E
Sbjct: 1476 KESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE----QIAEGGKRIHELE 1531

Query: 474  RAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRC 533
            +  K +  E+ E  + L      +E       G  L  + E N ++ EV     +     
Sbjct: 1532 KIKKQVEQEKSELQAALEEAEASLEHE----EGKILRIQLELNQVKSEVDRKIAEKDEEI 1587

Query: 534  D-MCSNYEKQLQGIQIQ-EAETRDQ-------------VKKLQLMLRQANDQLEKTMKDK 578
            D M  N+ + ++ +Q   +AE R +             + ++++ L  AN    + +++ 
Sbjct: 1588 DQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1647

Query: 579  QELEDFIK----------QSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQM 628
            +  +  +K          +S ED   Q++ +  RA   +  +EEL+  L Q +R      
Sbjct: 1648 RNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER------ 1701

Query: 629  AVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDI 688
                 SR+   +EL+     ++ +Q  H+ + SL   +  +  D ++   E+     EDI
Sbjct: 1702 -----SRKIAEQELL---DASERVQLLHTQNTSLINTKKKLETDISQIQGEM-----EDI 1748

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQ-------CLKENLEETLQLEIENCKEEIASI 741
            I     A+   +K   +   + E+++ EQ        +K+NLE+T++ ++++  +E   +
Sbjct: 1749 IQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK-DLQHRLDEAEQL 1807

Query: 742  SSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEK 801
             +LK   ++I+    +LE+ +RE   ++ES Q+  +   + L+K       +     E++
Sbjct: 1808 -ALKGGKKQIQ----KLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDR 1862

Query: 802  NKAQRLQTELDVSEQVQRDFVKLSQTLQVQ 831
                RLQ  +D  +   + + + ++  + Q
Sbjct: 1863 KNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 184/919 (20%), Positives = 367/919 (39%), Gaps = 132/919 (14%)

Query: 16   QRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLR 75
            +R  + E+INAE    +++LE E ++ +    +L L   +  K ++A     ++      
Sbjct: 928  ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN------ 981

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR 135
              L E  A ++   A  T  +   QEA  +     + E   +  + K  ++  +    L 
Sbjct: 982  --LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLE 1039

Query: 136  --LEQERTQWAQYRESAEREIADLRRRLSEGQEEEN----LENEMKKAQEDAEKLRSVVM 189
              LEQE+        +  +   DL+       + EN    L+ ++KK + +   L+S + 
Sbjct: 1040 GSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKI- 1098

Query: 190  PMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
               ++  AL  +L   + KIKEL+A +++EL   +EAE++ R   E        Q+S L 
Sbjct: 1099 ---EDEQALGMQL---QKKIKELQA-RIEELEEEIEAERASRAKAE-------KQRSDLS 1144

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E++ + L E       + + +       +K   +F + +R L     + E    + +
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMN-------KKREAEFQKMRRDLEEATLQHEATAATLR 1197

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEI---------------KIPVVCALTQ 354
             +  + + +  ++ D  QR+ ++ + +K++++ EI                +  +C   +
Sbjct: 1198 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE 1257

Query: 355  EESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTS 414
            ++ S ++  +EE        + +  A L   SG+   + D    KD L    S      +
Sbjct: 1258 DQLS-EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDE---KDTLVSQLSRGKQAFT 1313

Query: 415  GSLQ--SKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF------ 466
              ++   + L    KAKSA  L  +        D + E ++       ++          
Sbjct: 1314 QQIEELKRQLEEEIKAKSA--LAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSE 1371

Query: 467  ---MLTKDQERAIKAMTPEQEETASLLSSVTQGMES---------AYVSPSGYRLVSETE 514
                 TK +  AI+  T E EE    L+   Q  E          A +  +  RL +E E
Sbjct: 1372 VAQWRTKYETDAIQ-RTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVE 1430

Query: 515  WNLLQKEVHNAG----NKLGRRCD--------MCSNYEKQLQGIQIQEAETRDQVKKLQL 562
              ++  E  NA     +K  R  D         C     +L+  Q +      ++ K++ 
Sbjct: 1431 DLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKN 1490

Query: 563  MLRQANDQLEKTMKD----KQELEDFIKQSSEDSS--HQISALVLRAQAS----EILLEE 612
               ++ DQLE   ++    +QE+ D  +Q +E     H++  +  + +      +  LEE
Sbjct: 1491 AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEE 1550

Query: 613  LQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV-SLQQAEDFILP 671
             +  L   +  +      L Q + +V  ++    ++ D ++  H   V S+Q   D  + 
Sbjct: 1551 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIR 1610

Query: 672  DTTEALRELVLKYREDIINVRTAADHVEEK--------------LKAEILFLKEQIQAEQ 717
               +A+R L  K   D+  +    +H                  LK   L L + +++++
Sbjct: 1611 SRNDAIR-LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQE 1669

Query: 718  CLKENL------EETLQLEIENCK---------EEIASISSLKAELERIKVEKGQLESTL 762
             LKE L         LQ EIE  +          +IA    L A  ER+++   Q  S +
Sbjct: 1670 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDAS-ERVQLLHTQNTSLI 1728

Query: 763  REKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFV 822
              K +    + +I+  +E+ +++   A+   ++ + +    A+ L+ E D S  ++R   
Sbjct: 1729 NTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788

Query: 823  KLSQTLQVQLERIRQADSL 841
             L QT++    R+ +A+ L
Sbjct: 1789 NLEQTVKDLQHRLDEAEQL 1807



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 160/797 (20%), Positives = 331/797 (41%), Gaps = 76/797 (9%)

Query: 88   IKAIATVSENTKQEA-IDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQY 146
            IK +   +E  K+ A + E   + +EE+A  +A  KE       +  + L QE+      
Sbjct: 840  IKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKEL-----EEKMVTLMQEKNDLQLQ 894

Query: 147  RESAEREIADLRRRLSEGQEEE-NLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEA 205
             ++    +AD   R  +  + +  LE ++K+  E AE    +   +  +   L+D+ +E 
Sbjct: 895  VQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954

Query: 206  EDKIKELE--ASKVKELNHYLEAEKSCRTD----LEMYVAVLNTQKSVLQEDAEKLRKEL 259
            +  I +LE   +KV++  H  E +    T+    L+  +A L  +K  LQE  ++   + 
Sbjct: 955  KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD- 1013

Query: 260  HEVCHLLEQERQQHNQLKHTWQKANDQF------LESQRLLMRDMQRMEIVLTSEQLRQV 313
                  L+ E  + N L     K   Q       LE ++ +  D++R +  L  + L+  
Sbjct: 1014 ------LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGD-LKLA 1066

Query: 314  EELKKKDQEDDEQQRLNKRKDHK------KADVEEEIKIPVVCALTQEESSAQLSNEEEH 367
            +E    D E+D+QQ   K K  +      ++ +E+E  + +      +E  A++   EE 
Sbjct: 1067 QE-STMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125

Query: 368  LDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYK 427
            +++ R S    +            K  +D+ ++     + ++ L  +G   S  +  N K
Sbjct: 1126 IEAERASRAKAE------------KQRSDLSRE---LEEISERLEEAGGATSAQIEMNKK 1170

Query: 428  -----AKSAGNLDESDFGPLVGADSVSENF--DTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  K   +L+E+       A ++ +      A LG  Q+ +   + +  E+    M 
Sbjct: 1171 REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE-QIDNLQRVKQKLEKEKSEMK 1229

Query: 481  PEQEETASLLSSVTQ---GMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCS 537
             E ++ AS + +V++    +E    +        +T+    Q+ +++   +  R      
Sbjct: 1230 MEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESG 1289

Query: 538  NYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQIS 597
             Y +QL     ++     Q+ + +    Q  ++L++ ++++ + +  +  + + S H   
Sbjct: 1290 EYSRQLD----EKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCD 1345

Query: 598  ALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHS 657
             L  + +  +    ELQ+ +S+A  +V +          Q +EEL   +K          
Sbjct: 1346 LLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405

Query: 658  LHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVE------EKLKAEILFLKE 711
             HV    A+   L  T + L+  V     D+     A   ++      +K+ AE     E
Sbjct: 1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCE 1465

Query: 712  QIQAEQCLKENLEETLQLEIENCK----EEIASISSLKAELERIKVEKGQLESTLREKSQ 767
            +  AE    +    +L  E+   K    E +  + +LK E + ++ E   L   + E  +
Sbjct: 1466 ETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1525

Query: 768  QLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELD-VSEQVQRDFVKLSQ 826
            ++  L++IK  +E++  +  AA    E  +  E+ K  R+Q EL+ V  +V R   +  +
Sbjct: 1526 RIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE 1585

Query: 827  TL-QVQLERIRQADSLE 842
             + Q++   IR  +S++
Sbjct: 1586 EIDQMKRNHIRIVESMQ 1602



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 72/349 (20%), Positives = 157/349 (44%), Gaps = 48/349 (13%)

Query: 548  IQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELED---FIKQSSEDSSHQISA------ 598
            ++ AET  ++  ++    +  ++L KT   ++ELE+    + Q   D   Q+ A      
Sbjct: 844  LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLA 903

Query: 599  -------------LVLRAQASEIL-----LEELQQGLSQAKRDVQEQMAVLMQSREQVSE 640
                         + L A+  E+       EE+   L+  KR ++++ + L +  + +  
Sbjct: 904  DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963

Query: 641  ELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEE 700
             L +++K+  + + K           D  +   T+  + L   +++ + +++   D V  
Sbjct: 964  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1023

Query: 701  KLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELER-IKVEKGQLE 759
              KA+I   ++    E  L++  E+ +++++E  K ++     L  E    I+ +K QL+
Sbjct: 1024 LTKAKIKLEQQVDDLEGSLEQ--EKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLD 1081

Query: 760  STLREKSQQLESLQEIKISLEEQL-----KKETAAKATVEQLMFE-EKNKAQRLQTELDV 813
              L++K  ++  LQ  KI  E+ L     KK    +A +E+L  E E  +A R + E   
Sbjct: 1082 EKLKKKEFEMSGLQS-KIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140

Query: 814  SEQVQRDFVKLSQTL---------QVQLERIRQADSLERIRAILNDTKL 853
            S+ + R+  ++S+ L         Q+++ + R+A+  +++R  L +  L
Sbjct: 1141 SD-LSRELEEISERLEEAGGATSAQIEMNKKREAE-FQKMRRDLEEATL 1187



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 94/422 (22%), Positives = 174/422 (41%), Gaps = 63/422 (14%)

Query: 15   QQRVAELEKINAEFLRAQQQ---LEQEFNQKRAKFKELYLAK---EEDLKRQNAVLQAAQ 68
            ++ + +LE +  E    QQ+   L ++  +   +  EL   K   E++     A L+ A+
Sbjct: 1493 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAE 1552

Query: 69   DDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDY 128
              L H   ++   Q E+  +K+        K E ID++KR     V S+Q+ +   +R  
Sbjct: 1553 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSR 1612

Query: 129  EHQFHL--RLEQERTQWAQYRESAEREIADLRRRLSEGQ-----EEENLENEMKKAQEDA 181
                 L  ++E +  +       A R  A+  R     Q      + +L++ ++  ++  
Sbjct: 1613 NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLK 1672

Query: 182  EKLRSV---VMPMEKEIAALKDKL--TEAEDKIKE---LEASKVKELNH-----YLEAEK 228
            E+L  V      ++ EI  L+  L  TE   KI E   L+AS+  +L H      +  +K
Sbjct: 1673 EQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKK 1732

Query: 229  SCRTDLEMYVAVLNTQKSVLQED-----------------AEKLRKELHEVCHLLEQER- 270
               TD+     +    + ++QE                  AE+L+KE     HL   ++ 
Sbjct: 1733 KLETDISQ---IQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789

Query: 271  --QQHNQLKHTWQKANDQFLES-----QRLLMRDMQRMEIVLTSEQLRQVEELK------ 317
              Q    L+H   +A    L+      Q+L  R ++ +E  + SEQ R VE +K      
Sbjct: 1790 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAR-VRELEGEVESEQKRNVEAVKGLRKHE 1848

Query: 318  KKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHS 377
            +K +E   Q   +++   +  D+ ++++  V     Q E + + SN   +L   R   H 
Sbjct: 1849 RKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN--VNLSKFRRIQHE 1906

Query: 378  LD 379
            L+
Sbjct: 1907 LE 1908



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 68/320 (21%), Positives = 136/320 (42%), Gaps = 33/320 (10%)

Query: 559  KLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLS 618
            K++ +L+ A  + EK M + +E  +F K   E         + + +A    LEE    L 
Sbjct: 839  KIKPLLKSA--ETEKEMANMKE--EFEKTKEE---------LAKTEAKRKELEEKMVTLM 885

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALR 678
            Q K D+Q Q+     S     E   +L K    L+ K        + E+ I  + T   R
Sbjct: 886  QEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKR 945

Query: 679  EL---VLKYREDIINVRTAADHVEEK----------LKAEILFLKEQIQAEQCLKENLEE 725
            +L     + ++DI ++      VE++          L  E+  L E I      K+ L+E
Sbjct: 946  KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1005

Query: 726  TLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLK- 784
              Q  +++ + E   +++L     +++ +   LE +L ++ +    L+  K  LE  LK 
Sbjct: 1006 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKL 1065

Query: 785  -KETAAKATVEQLMFEEKNKAQR-----LQTELDVSEQVQRDFVKLSQTLQVQLERIRQA 838
             +E+      ++   +EK K +      LQ++++  + +     K  + LQ ++E + + 
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125

Query: 839  DSLERIRAILNDTKLTDINQ 858
               ER      + + +D+++
Sbjct: 1126 IEAERASRAKAEKQRSDLSR 1145


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  100 bits (249), Expect = 6e-21
 Identities = 182/915 (19%), Positives = 374/915 (40%), Gaps = 120/915 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            + +R+ + E++NAE    +++LE E ++ +    +L L   +  K ++A     ++    
Sbjct: 922  MNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKN---- 977

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFH 133
                L E  A ++ I A  T  +   QEA  +     + E   +  + K  V+  +    
Sbjct: 978  ----LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDD 1033

Query: 134  LR--LEQERTQWAQYRESAEREIADLRRRLSEGQEEEN----LENEMKKAQEDAEKLRSV 187
            L   LEQE+        +  +   DL+       + EN    L+  +KK   +   L + 
Sbjct: 1034 LEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR 1093

Query: 188  VMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
            +   +   + L+ KL E + +I+ELE          LEAE++ R  +E   + L+ +   
Sbjct: 1094 IEDEQALGSQLQKKLKELQARIEELEEE--------LEAERTARAKVEKLRSDLSRELEE 1145

Query: 248  LQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTS 307
            + E  E+          + ++   +  +++   ++A  Q  E+    +R      +    
Sbjct: 1146 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH-EATAAALRKKHADSVAELG 1204

Query: 308  EQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIK----IPVVCALTQEESSAQLSN 363
            EQ+  ++ +K+K +++  + +L    D   +++E+ IK    +  +C   +++ +   S 
Sbjct: 1205 EQIDNLQRVKQKLEKEKSEFKL--ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSK 1262

Query: 364  EEEHLDSTRGSVHSLD---AGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420
             EE    T+ SV+ L    A L   +G+   + D    K+ L    +   L  +  L+  
Sbjct: 1263 AEE----TQRSVNDLTSQRAKLQTENGELSRQLDE---KEALISQLTRGKLTYTQQLEDL 1315

Query: 421  ALGYNYKAKSAGNLDESDFGPLVGADSVSENF--DTASLGSLQM---------------- 462
                  + K+   L  +        D + E +  +T +   LQ                 
Sbjct: 1316 KRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY 1375

Query: 463  -PSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKE 521
                   T++ E A K +    +E    + +V     S  +  + +RL +E E  ++  E
Sbjct: 1376 ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSS--LEKTKHRLQNEIEDLMVDVE 1433

Query: 522  VHNAG----NKLGRRCDMC-----SNYEKQLQGIQIQEAETRD---QVKKLQLMLRQAND 569
              NA     +K  R  D         YE+    ++  + E R    ++ KL+    ++ +
Sbjct: 1434 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493

Query: 570  QLEKTMKDKQELEDFIKQ------SSEDSSHQISALVLRAQASEILLEELQQGLSQAKRD 623
             LE   ++ + L++ I        SS  + H++  +  + +A ++   ELQ  L +A+  
Sbjct: 1494 HLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM---ELQSALEEAEAS 1550

Query: 624  VQEQMAVLMQSR---EQVSEELVR--LQKDNDSLQGKHS-LHV--SLQQAEDFILPDTTE 675
            ++ +   +++++    Q+  E+ R   +KD +  Q K + L V  SLQ + D       E
Sbjct: 1551 LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNE 1610

Query: 676  ALRELVLKYREDIINV---------RTAAD------HVEEKLKAEILFLKEQIQAEQCLK 720
            ALR  V K  E  +N          R AA+       ++  LK   + L + ++A   LK
Sbjct: 1611 ALR--VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1668

Query: 721  ENL------EETLQLEIENCKEEIASI--------SSLKAELERIKVEKGQLESTLREKS 766
            EN+         LQ E+E  +  +             L    ER+++   Q  S + +K 
Sbjct: 1669 ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK 1728

Query: 767  QQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQ 826
            +    L +++  +EE +++   A+   ++ + +    A+ L+ E D S  ++R    + Q
Sbjct: 1729 KMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1788

Query: 827  TLQVQLERIRQADSL 841
            T++    R+ +A+ +
Sbjct: 1789 TIKDLQHRLDEAEQI 1803



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 174/897 (19%), Positives = 366/897 (40%), Gaps = 84/897 (9%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQ---QQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQ 65
            Q D  L+++  EL  +NA     Q    QL+++  + +A+ +EL    EE+L+ +     
Sbjct: 1075 QLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL----EEELEAERTARA 1130

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAIATVS--ENTKQEAIDEVKRQWREEVASLQAVMKE 123
              +     L  +L E    +E      +V    N K+EA  +  R+  EE          
Sbjct: 1131 KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1190

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEK 183
             +R         L ++     + ++  E+E ++ +  L +     N+E ++ KA+ + EK
Sbjct: 1191 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD--VTSNME-QIIKAKANLEK 1247

Query: 184  LRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVK------ELNHYLEAEKSCRTDLEMY 237
            +      +E ++   + K  E +  + +L + + K      EL+  L+ +++  + L   
Sbjct: 1248 M---CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304

Query: 238  VAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRD 297
                  Q   L+   E+  K  + + H L+  R   + L+  +++  +   E QR+L + 
Sbjct: 1305 KLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA 1364

Query: 298  MQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEES 357
               +    T  +   +       Q  +E +   K+   +  + EE ++       + E++
Sbjct: 1365 NSEVAQWRTKYETDAI-------QRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417

Query: 358  SAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSL 417
              +L NE E L       ++  A L     D   ++ + +  +  ++ + + S   S   
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAAL-----DKKQRNFDKILAEWKQKYEESQSELESSQK 1472

Query: 418  QSKALGYN-YKAKSAGNLDESDFGPLVGADSVSENF-DTASLGSLQMPSGFMLTKDQERA 475
            ++++L    +K K   N  E     L      ++N  +  S  + Q+ S      + E+ 
Sbjct: 1473 EARSLSTELFKLK---NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529

Query: 476  IKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDM 535
             K +  E+ E    L S  +  E++     G  L ++ E+N ++ E+     +     + 
Sbjct: 1530 RKQLEAEKME----LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1585

Query: 536  CS-NYEKQLQGIQIQ-EAETRD-----QVKK--------LQLMLRQANDQLEKTMKDKQE 580
               N+ + +  +Q   +AETR      +VKK        +++ L  AN    +  K  + 
Sbjct: 1586 AKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 1645

Query: 581  LEDFIK----------QSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAV 630
            L+  +K          ++++D    I+ +  R    +  LEEL+  + Q +R       +
Sbjct: 1646 LQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER----SRKL 1701

Query: 631  LMQSREQVSEELVRLQKDNDSL-QGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDII 689
              Q   + SE +  L   N SL   K  +   L Q +  +  +  +  R    K ++ I 
Sbjct: 1702 AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV-EEAVQECRNAEEKAKKAIT 1760

Query: 690  NVRTAADHV--EEKLKAEILFLKEQI-QAEQCLKENLEETLQLEIENCKEEIASISSLKA 746
            +    A+ +  E+   A +  +K+ + Q  + L+  L+E  Q+ ++  K+++  + +   
Sbjct: 1761 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1820

Query: 747  ELE-RIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQ 805
            ELE  ++ E+ +   +++   +    ++E+    EE  K     +  V++L    K KA 
Sbjct: 1821 ELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQL--KVKAY 1878

Query: 806  RLQTELDVSEQVQRD---FVKLSQTLQVQLERIRQADS-LERIRAILNDTKLTDINQ 858
            + Q E +  EQ   +   F K+   L    ER   A+S + ++RA   D     +N+
Sbjct: 1879 KRQAE-EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLNE 1934



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 164/814 (20%), Positives = 314/814 (38%), Gaps = 139/814 (17%)

Query: 151  EREIADLRRRLSEGQEE-ENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKI 209
            E+E+A ++   +  +E  E  E   K+ +E    L      ++ ++ A +D L +AE++ 
Sbjct: 846  EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905

Query: 210  KELEASK------VKELNHYLEAEKSCRT---------------------DLEMYVAVLN 242
             +L  +K      VKE+N  LE E+                         DLE+ +A + 
Sbjct: 906  DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVE 965

Query: 243  TQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQF--------------- 287
             +K   +   + L +E+  +  ++ +  ++   L+   Q+A D                 
Sbjct: 966  KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025

Query: 288  ------------LESQRLLMRDMQRM------EIVLTSEQLRQV--------EELKKKDQ 321
                        LE ++ +  D++R       ++ LT E +  +        E LKKKD 
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDF 1085

Query: 322  E--------DDEQ------QRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEH 367
            E        +DEQ      Q+  K    +  ++EEE++         E+  + LS E E 
Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE 1145

Query: 368  LD---STRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGY 424
            +       G   S+   +       F K   D+ +  L+   +  +L    +     LG 
Sbjct: 1146 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE 1205

Query: 425  N----YKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  + K     ++S+F   +  D V+ N +        +       +DQ    ++  
Sbjct: 1206 QIDNLQRVKQKLEKEKSEF--KLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
             E + + + L+S               R   +TE   L +++      + +       Y 
Sbjct: 1264 EETQRSVNDLTS--------------QRAKLQTENGELSRQLDEKEALISQLTRGKLTYT 1309

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQA-------NDQLEKTMKDKQELEDFIKQSSEDSS 593
            +QL+ ++ Q  E       L   L+ A        +Q E+  + K EL+  + +++ + +
Sbjct: 1310 QQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1369

Query: 594  HQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQ 653
               +     A      LEE ++ L+Q  ++ +E +  +      + +   RLQ + + L 
Sbjct: 1370 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1429

Query: 654  GKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQI 713
                   +   A D    +  + L E   KY E       +   +E   K       E  
Sbjct: 1430 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEE-------SQSELESSQKEARSLSTELF 1482

Query: 714  QAEQCLKENLE--ETLQLEIENCKEEIASI-----SSLKAELERIKVEKGQLESTLREKS 766
            + +   +E+LE  ET + E +N +EEI+ +     SS K   E  KV K QLE+   EK 
Sbjct: 1483 KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK-QLEA---EKM 1538

Query: 767  QQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQ 826
            +   +L+E + SLE +  K   A+    Q+  E + K      E+   EQ +R+ +++  
Sbjct: 1539 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM---EQAKRNHLRVVD 1595

Query: 827  TLQVQLERIRQADSLERIRAILNDTKLT-DINQL 859
            +LQ  L+    A++  R  A+    K+  D+N++
Sbjct: 1596 SLQTSLD----AETRSRNEALRVKKKMEGDLNEM 1625



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 72/325 (22%), Positives = 136/325 (41%), Gaps = 53/325 (16%)

Query: 559  KLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLS 618
            K++ +L+ A  + EK M   +E    +K++ E S           +A    LEE    L 
Sbjct: 835  KIKPLLKSA--EREKEMASMKEEFTRLKEALEKS-----------EARRKELEEKMVSLL 881

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGK-HSLHVSLQQAEDFILPDTTE-- 675
            Q K D+Q Q+     +     E   +L K+   L+ K   ++  L+  E+     T +  
Sbjct: 882  QEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKR 941

Query: 676  ALRELVLKYREDIINVRTAADHVEEK----------LKAEILFLKEQIQAEQCLKENLEE 725
             L +   + + DI ++      VE++          L  E+  L E I      K+ L+E
Sbjct: 942  KLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1001

Query: 726  TLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKK 785
              Q  +++ + E   +++L     +++ +   LE +L ++ +    L+  K  LE  L  
Sbjct: 1002 AHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL-- 1059

Query: 786  ETAAKATVEQLMFEEKNKAQ-----------------RLQTELDVSEQVQRDFVKLS--- 825
                K T E +M  E +K Q                 R++ E  +  Q+Q+   +L    
Sbjct: 1060 ----KLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARI 1115

Query: 826  QTLQVQLERIRQADS-LERIRAILN 849
            + L+ +LE  R A + +E++R+ L+
Sbjct: 1116 EELEEELEAERTARAKVEKLRSDLS 1140



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 28/120 (23%), Positives = 57/120 (47%), Gaps = 4/120 (3%)

Query: 736 EEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQ 795
           E    ++S+K E  R+K    + E+  +E  +++ SL + K  L+ Q++ E    A  E+
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903

Query: 796 LMFE-EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLT 854
              +  KNK   +Q E  V E  +R   +     ++  ++ +  D    ++  ++D +LT
Sbjct: 904 RCDQLIKNK---IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELT 960


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  100 bits (249), Expect = 6e-21
 Identities = 186/893 (20%), Positives = 348/893 (38%), Gaps = 88/893 (9%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            LQ+   +L K+  + LR ++Q E++  Q+        L +E+ L+R+    +  Q +   
Sbjct: 271  LQEEEEQLRKLERQELRRERQEEEQQQQR--------LRREQQLRRKQEEERREQQEERR 322

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFH 133
             + +  E Q E    +      E  +Q+   E + + RE+    +   +   +    +  
Sbjct: 323  EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 134  LRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEK 193
            LR EQ+  +  Q R   +       RR  + + E+ L  E +  +E  E+        E+
Sbjct: 383  LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442

Query: 194  EIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD--LEMYVAVLNTQKSVLQED 251
                LK +  E  D +K  E ++  E     +  K  + +   E ++ +   ++   QE 
Sbjct: 443  REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502

Query: 252  AE-KLRKE----------LHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR 300
             E +LR+E            E    L+Q  +   QL+   ++  +Q L+ +     + +R
Sbjct: 503  REQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562

Query: 301  MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ 360
             E  L  EQ  + ++L K+ +E+  QQRL + ++ +   +E+ +K   V  L QEE   Q
Sbjct: 563  REQRLKREQEERRDQLLKR-EEERRQQRLKREQEER---LEQRLKREEVERLEQEERREQ 618

Query: 361  LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGL-RRAQSTDSLGTSGSLQS 419
                EE  +  R          LL S +   +    + ++   RR Q          L+ 
Sbjct: 619  RLKREEPEEERRQQ--------LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ 670

Query: 420  KALGYNYKAKSAGNLDESD---FGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAI 476
            +    + + +    L E +       + +      +   S    +    +   + QE   
Sbjct: 671  RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR 730

Query: 477  KAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAG-NKLGRRCDM 535
            +    E++          Q  E A+          +  W    +E    G  +L  R  +
Sbjct: 731  RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790

Query: 536  CSNYEKQLQGIQIQEAE----------------TRDQVKKLQLMLRQANDQLEKTMKDKQ 579
                E+QL+  + Q+ E                 R++ K+LQ +  +   Q  +  +  Q
Sbjct: 791  REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850

Query: 580  ELEDFIKQSSEDSSHQISALVLRAQASEILLEE---LQQGLSQAKRDVQEQMAVLMQSRE 636
            E ED ++   ED   + S    R Q     LEE    ++    AK  +QEQ+    Q  +
Sbjct: 851  EEEDGLQ---EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ 907

Query: 637  QVSEELVRLQKDNDSLQGKHSLH---VSLQQAEDFILPDTTEALR--ELVLKYRED---- 687
            +  EEL R +++    Q +   +     LQQ E+ +L +  E  R  E   +YR+D    
Sbjct: 908  EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967

Query: 688  -----IINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASIS 742
                 ++         +E+ K      + Q + EQ L+E  E+  + E E    +   + 
Sbjct: 968  QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ 1027

Query: 743  SLKAELERIKVEKGQLESTLREKSQQLESLQE------------IKISLEEQLKKETAAK 790
              + +L R + EK +L+   R+  ++ E  QE             +  LE Q +KE   +
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087

Query: 791  ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 843
               EQL+ EE  K +R + E    E+ +    +  Q L+ + E+ R+   LER
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQ-QEEEQLLREEREK-RRRQELER 1138



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 181/897 (20%), Positives = 350/897 (39%), Gaps = 150/897 (16%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKEL-YLAKEEDLKRQNAVLQAAQDDLG- 72
            Q R  E ++    FL  +++ EQ   Q+R + KEL +L +EE L+R+    Q  +++ G 
Sbjct: 797  QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGL 856

Query: 73   -----------HLRTQLWEAQAEMENIKAIATV-SENTKQEAIDEVKRQWREEVASLQAV 120
                         R Q W  Q E E  +   T+ ++   QE + + ++  +EE   LQ  
Sbjct: 857  QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916

Query: 121  MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEG----------QEEENL 170
             +E  R  E +   R  +E  Q  Q  E   RE  + RRR              Q+EE L
Sbjct: 917  EREKRRRQEQE---RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL 973

Query: 171  ---ENEMKKAQEDAEKLRSVVMPMEKEIAAL------------------KDKLTEAEDKI 209
               E E ++ QE  +K R      ++E   L                  KD+L + E+++
Sbjct: 974  LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL 1033

Query: 210  --KELEASKVKELNHYLEAEKSCRTDLEMYVA--------------------VLNTQKSV 247
              +E E  +++E       E+  + + E  +                     +   ++ +
Sbjct: 1034 LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093

Query: 248  LQEDAEKLRKELHEVCHLLEQERQQHNQ--LKHTWQKANDQFLESQRLLMRDMQRMEIVL 305
            L+E+ EK R++  E     E+E QQ  +  L+   +K   Q LE Q     ++Q+ E  L
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153

Query: 306  TSE------------QLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
              E            Q R+ EEL++++++   +++  +R++ ++   EEE        L 
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEE-------ELQ 1206

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKS---DNDMFKDGLRRAQSTDS 410
            +++   +  +E++  D             L    +P  ++   DN ++  G    Q    
Sbjct: 1207 RQKRKQRYRDEDQRSD-------------LKWQWEPEKENAVRDNKVYCKGRENEQFR-- 1251

Query: 411  LGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTA---SLGSLQMPSGFM 467
                  L+   L             + D   L+G     +               P    
Sbjct: 1252 -----QLEDSQL--------RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ 1298

Query: 468  LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR----LVSETEWNLLQKEVH 523
            L +++++  K    + +E   LL    +       +   +R    L+ E E   L+++  
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358

Query: 524  NA--GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQL--EKTMKDKQ 579
            +     +  R  +    + ++ Q ++ QE E +   ++ QL  ++   QL  ++  K ++
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418

Query: 580  ELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVS 639
            E +   +Q  +    +    V R +     LEE QQ   +  R  +E+  +L +  EQ  
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ-- 1476

Query: 640  EELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVE 699
             +L R ++D   L+ +  L    +Q  D    +     +E   K+ E+    +      +
Sbjct: 1477 -QLHRQERDRKFLEEEQQLR---RQERDRKFREQELRSQEPERKFLEE--EQQLHRQQRQ 1530

Query: 700  EKLKAEILFLKEQIQAEQCLKE---NLEETLQLEIENCKEEIA-SISSLKAELERIKVEK 755
             K   E   L+ Q + +Q  ++      E  QL  E  +++++      K  LE  KV +
Sbjct: 1531 RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRR 1590

Query: 756  GQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELD 812
             + E    E  QQL   +      ++QL++E   K   ++ + +E+ + Q  + E D
Sbjct: 1591 QEQERKFMEDEQQLRRQEG-----QQQLRQERDRKFREDEQLLQEREEQQLHRQERD 1642



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 196/923 (21%), Positives = 364/923 (39%), Gaps = 147/923 (15%)

Query: 15   QQRVAELEKINAEFLRAQQQL---EQEFNQKRAKFKELYLAKEEDLKRQN----AVLQAA 67
            ++R  +L K   +  R QQQL   +QE  ++R K +E     E+ LKR++       + A
Sbjct: 627  EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686

Query: 68   QDDLGHLRTQL------W------EAQAEMENIKAIATVSENTKQEAIDEVKR------- 108
            +++    R ++      W      EA A    + +     E  ++    E KR       
Sbjct: 687  EEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL 746

Query: 109  QWREEV-ASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEE 167
            QW+EE  A  Q   +E  RD+  Q+     +E+++  + R SA   + + R R    +E 
Sbjct: 747  QWQEEERAHRQQQEEEQRRDFTWQWQ---AEEKSERGRQRLSARPPLREQRERQLRAEER 803

Query: 168  ENLENEMKKAQEDAEKLRSVVMPMEKEIAALKD-----------KLTEAEDKIKE----- 211
            +  E      +E+ E+ R      EKE+  L++           +L E ED ++E     
Sbjct: 804  QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR 863

Query: 212  --LEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQ----KSVLQEDAEKLRKELHEVCHL 265
               E  + ++    LE E+  R         L  Q    + +LQE+ E+L++E  E    
Sbjct: 864  RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRR 923

Query: 266  LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEE--LKKKDQED 323
             EQERQ   +     Q+  +Q L  +R   R  +R       ++L+Q EE  L ++ ++ 
Sbjct: 924  QEQERQYREE--EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981

Query: 324  DEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLL 383
              Q+R  K ++ ++   EEE        L +EE   +   E E     +  +   +  LL
Sbjct: 982  RRQEREKKYREEEELQQEEE-------QLLREEREKRRRQEWERQYRKKDELQQEEEQLL 1034

Query: 384  LPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLV 443
                    + +    ++  R+ +  + L      + + LG   + +    L+        
Sbjct: 1035 R------EEREKRRLQERERQYREEEELQQE---EEQLLGEERETRRRQELERQ------ 1079

Query: 444  GADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSV-----TQGME 498
                  E         L+        +++ER  +     Q+E   LL         Q +E
Sbjct: 1080 --YRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELE 1137

Query: 499  SAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETR-DQV 557
              Y        V + E  LL++E         RR ++   Y ++ +  Q +E   R +Q 
Sbjct: 1138 RQYREEEE---VQQEEEQLLREEPEKR-----RRQELERQYREEEELQQEEEQLLREEQE 1189

Query: 558  KKLQLMLRQANDQLE-KTMKDKQELED------------------------FIKQSSEDS 592
            K+ Q   RQ  ++ E +  K KQ   D                        + K    + 
Sbjct: 1190 KRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQ 1249

Query: 593  SHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQ------ 646
              Q+    LR + S+   ++LQ  L + +   +EQ     Q R++   E  +L+      
Sbjct: 1250 FRQLEDSQLRDRQSQ---QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKE 1306

Query: 647  ---KDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV--EEK 701
               +D  S + K  L    ++       D      E +L+ RE+    R   D    EE+
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEE 1366

Query: 702  LK-----AEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKG 756
            L+      + L  +++++ ++  ++ L+E  QL  +  ++++      K   E  ++ + 
Sbjct: 1367 LRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ 1426

Query: 757  QLESTLREKSQQLESLQEIKISLEE--QLKKETAAKATVEQLMFEEKNKAQRLQTELDVS 814
            + +   RE+ QQ+   +  +  LEE  QL++E   K   E+ + +E+ + Q  + E D  
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD-- 1484

Query: 815  EQVQRDFVKLSQTLQVQLERIRQ 837
                R F++  Q L+ Q ER R+
Sbjct: 1485 ----RKFLEEEQQLRRQ-ERDRK 1502



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 79/352 (22%), Positives = 157/352 (44%), Gaps = 28/352 (7%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQ 68
            +P+   +Q +    +   E  + ++QL +E  +KR + +E    +EE+L+RQ    +   
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRD 1216

Query: 69   DDLGHLRTQL-WEAQAEMENI----KAIATVSENTKQEAIDEVKRQWREEVASLQAVMKE 123
            +D    R+ L W+ + E EN     K      EN +   +++ + + R+    LQ ++ E
Sbjct: 1217 ED---QRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE 1273

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL----ENEMKKAQE 179
                   Q   R +Q    + +  +    E  + +RR  + QEE+ L      E ++ QE
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333

Query: 180  DAEKLR-SVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
               K R    +  E+E   L+ +  E + K +E E    ++   +LE E+  R       
Sbjct: 1334 TDRKFREEEQLLQEREEQPLRRQ--ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
             +   Q+   QE  ++LR++         + R++  QL    Q+ + +F E ++ + R  
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRD------RKFREEEQQLSR--QERDRKFREEEQQVRRQE 1443

Query: 299  QRMEIVLTSEQLRQVEELKKKD-----QEDDEQQRLNKRKDHKKADVEEEIK 345
            +  + +   +QLRQ    K ++     QE +EQQ   + +D K  + E++++
Sbjct: 1444 RERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 167/880 (18%), Positives = 351/880 (39%), Gaps = 83/880 (9%)

Query: 33  QQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIA 92
           Q   QE +Q+R + ++  L +E   +R+    Q  Q+       +L E + + E  + + 
Sbjct: 111 QDRRQEEDQRRFEPRDRQLEEEPGQRRR----QKRQEQ----ERELAEGEEQSEKQERLE 162

Query: 93  TVSENTKQEAIDEVKRQWRE------EVASLQAVMKETVRDYEHQFHLRLEQERTQWAQY 146
                 + E +   +++W+E      E   LQ+       ++  +  LR  +      + 
Sbjct: 163 QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222

Query: 147 RESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAE 206
           RE  +++  + + R+ + +EE+         +++ EKL+      ++E+   +++L + E
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 207 DKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLL 266
            +    E  + ++    L  E+  R   E        ++   QE  E+ ++E  E     
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ-QEERREQQLRR 341

Query: 267 EQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSE-QLRQVEELKKKDQEDDE 325
           EQE ++  QL+   ++  ++  E Q    ++ +R E  L  E QLR+ ++L+++ Q   E
Sbjct: 342 EQEERREQQLR---REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398

Query: 326 QQRLNKRKDHKKADV--EEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLL 383
           QQ   +++  ++  +  E++++        QEE   +  +E+E  +  R      +    
Sbjct: 399 QQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ-RLKREQEERRDW 457

Query: 384 LPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLV 443
           L   +   + + +  K  L+R Q  +       L+ +      + +      E +     
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE----E 513

Query: 444 GADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVS 503
             +   +  +       ++ S   L ++QE   + +   +EE         Q ++     
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573

Query: 504 PSGYRLVSETE---WNLLQKEVHNAGNKLGR-RCDMCSNYEKQLQGIQIQE--AETRDQV 557
                L  E E     L +++      +L R   +     E++ Q ++ +E   E R Q+
Sbjct: 574 RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQL 633

Query: 558 KKLQLMLRQANDQLEKTMKDKQE-----------LEDFIK-QSSEDSSHQISALVLRAQA 605
            K +    +   QL +  ++++E           LE  +K +  E+   Q  A   + QA
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA 693

Query: 606 SEILLEELQQGLSQAKRDVQEQMAVLM--------QSREQVSEELVRLQKDNDSLQGKHS 657
            E +   + +   Q + +   + + +         Q R Q  EE  R ++     Q +  
Sbjct: 694 RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753

Query: 658 LHVSLQQAE---DFILPDTTEALRE---LVLKYREDIINVRTAADHVEEKLKAEILFLKE 711
            H   Q+ E   DF      E   E     L  R  +   R      EE+ + E  FL E
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813

Query: 712 QIQAEQCLKENLEETLQLEIENCKEEI---ASISSLKAELERIKVEKGQLESTLREKSQ- 767
           + + EQ  ++  E   +L+    +E++        L+ E + ++ ++ +  S  + + Q 
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873

Query: 768 ---QLESLQE-------IKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQV 817
              QLE  ++        K +L+EQL+KE       +QL+ EE+ + QR + E    ++ 
Sbjct: 874 WRWQLEEERKRRRHTLYAKPALQEQLRKE-------QQLLQEEEEELQREEREKRRRQEQ 926

Query: 818 QRDFVKLSQTLQVQLERIRQADS----LERIRAILNDTKL 853
           +R + +  Q  Q + + +R+        ER R    D KL
Sbjct: 927 ERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 78/348 (22%), Positives = 159/348 (45%), Gaps = 37/348 (10%)

Query: 27   EFLRAQQQLE-QEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH-LRTQLWEAQAE 84
            +FL+ +QQL  QE  Q+R + ++    +EE L+++    Q ++ +     R +  + + +
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591

Query: 85   MENIKAIATVSENTKQEAIDEVK----RQWREEVASLQAVMKETVRDYEHQFHLRLEQER 140
             +  K +    +  +QE   +++    R++RE+   LQ   ++ +   E      LE+E 
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF-LEEEP 1650

Query: 141  TQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKD 200
                Q RE   R   D + R  E   +E  E ++++ + D  K R     + ++      
Sbjct: 1651 QLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD-RKFREEEQQLRRQ------ 1703

Query: 201  KLTEAEDK-IKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKEL 259
               E E K ++E +  + +EL      E+  R + E        Q+ + ++  E+ RK L
Sbjct: 1704 ---ERERKFLQEEQQLRRQELERKFREEEQLRQETE--------QEQLRRQ--ERYRKIL 1750

Query: 260  HEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM-RDMQRMEIVLTSEQLRQVEELKK 318
             E     EQ R +  + +   Q+ + +F E ++L   R+ Q++    +  + R+ E+L+ 
Sbjct: 1751 EE-----EQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR- 1804

Query: 319  KDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
              QE +EQQ   +++D K    EE++++       ++E   Q   EE+
Sbjct: 1805 --QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 77/366 (21%), Positives = 153/366 (41%), Gaps = 45/366 (12%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEED-LKRQNAVLQAA 67
            Q +   + R ++ EK      R +++  QE ++K  + ++L   +EE  L+RQ    +  
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363

Query: 68   QDDLGHLRT---------QLWEAQAEMENIKAIATVS-ENTKQEAIDEVKRQWREEVASL 117
            +++L H            +L   + E + +K    +  +  +Q+   +  R++REE   L
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423

Query: 118  QAVMKETVRDYEHQFHLRLEQERT---QWAQYRESAEREIADLRRRLSEGQEEENLENEM 174
                ++     E Q   R E+ER    +  Q R+   R+  +  + L E +E++    E 
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483

Query: 175  -KKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD 233
             +K  E+ ++LR                  E + K +E E    +    +LE E+     
Sbjct: 1484 DRKFLEEEQQLRR----------------QERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527

Query: 234  LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQF------ 287
                  +   Q+   QE  ++ R++        EQ RQ+  + + + Q+ + +F      
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587

Query: 288  ---LESQRLLMRDMQRMEIVLTSEQLRQVEELKKKD-----QEDDEQQRLNKRKDHKKAD 339
                E +R  M D Q++      +QLRQ  + K ++     QE +EQQ   + +D K  +
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647

Query: 340  VEEEIK 345
             E +++
Sbjct: 1648 EEPQLR 1653



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 62/276 (22%), Positives = 123/276 (44%), Gaps = 26/276 (9%)

Query: 103 IDEVKRQWREEVASL--QAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRR 160
           +DE KR   +   SL      +E  R +E +     E+   +  Q R+  ERE+A     
Sbjct: 95  LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA----- 149

Query: 161 LSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKEL 220
             EG+E+   E + +  Q D ++    +    +E    +++  E E    +L++ K  E 
Sbjct: 150 --EGEEQS--EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE----QLQSCKGHET 201

Query: 221 NHYLEAEKSCRTDL---------EMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQ 271
             + + E+  R +L         E        Q  V QE+ EK  ++   V    E++ Q
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261

Query: 272 QHN-QLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLN 330
           +   Q +   Q+  +Q  + +R  +R  +R E     ++LR+ ++L++K +E+  +Q+  
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELR-RERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320

Query: 331 KRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
           +R+  ++ + +EE +   +    +E    QL  E+E
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQE 356



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 61/286 (21%), Positives = 122/286 (42%), Gaps = 25/286 (8%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKEL---YLAKEEDLKRQNAVLQ 65
            +P +  Q+R  +L        R ++QL QE  +++ + +E    +  +E+ L+RQ    +
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEV--KRQWREEVASLQAVMKE 123
              Q++    R +L     E E ++      +  +QE   ++  + Q R E    Q   +E
Sbjct: 1709 FLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQE 1768

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEK 183
              R +  +  LR E+E  Q     + ++R+  +   +L + +EE+ L  + +  +   E+
Sbjct: 1769 RDRKFREEEQLRQEREEQQLRS--QESDRKFRE-EEQLRQEREEQQLRPQQRDGKYRWEE 1825

Query: 184  LRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNT 243
             +  +   E+ +   +D+   AE++    E S+ +E   + E E+  R            
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRR------------ 1873

Query: 244  QKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLE 289
                 QE   KLR+E        EQ  +Q  ++K    K + + LE
Sbjct: 1874 -----QERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 77/391 (19%), Positives = 158/391 (40%), Gaps = 56/391 (14%)

Query: 23   KINAEFLRAQQQ----LEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQL 78
            K   E LR Q+Q    LE+E   +R + +  +L +E+ L+ Q    Q  QD     R   
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR--- 1417

Query: 79   WEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQ 138
             E + ++   +      E  +Q    E +R++ EE   L+       R+ E     +L Q
Sbjct: 1418 -EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE-----QLLQ 1471

Query: 139  ERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAAL 198
            ER +   +R+  +R+  +  ++L   + +     +  ++QE   K       + ++    
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR 1531

Query: 199  KDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD----------------LEMYVAVLN 242
            K    E + + +E    + ++ +     E+  R +                LE       
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591

Query: 243  TQKSVLQEDAEKLRKELHEVCHLLEQER-----------QQHNQLKHTWQKANDQFLESQ 291
             Q+    ED ++LR++  E    L QER           Q+  + +   Q+ + +FLE +
Sbjct: 1592 EQERKFMEDEQQLRRQ--EGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649

Query: 292  RLLMRDMQRMEI-------VLTSEQLRQV---EELKKKDQE----DDEQQRLNKRKDHKK 337
              L R  +  ++           EQL Q    ++L++++++    ++EQQ   + ++ K 
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF 1709

Query: 338  ADVEEEIKIPVVCALTQEESSAQLSNEEEHL 368
               E++++   +    +EE   +   E+E L
Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQETEQEQL 1740



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 61/268 (22%), Positives = 116/268 (43%), Gaps = 29/268 (10%)

Query: 29   LRAQQQLEQEFNQKRAKFKE----LYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAE 84
            LR Q++ +Q  + +  KF+E    L   +E+ L+RQ    +  +++   LR Q  E +  
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQ-QLRRQERERKFL 1710

Query: 85   MENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWA 144
             E            +Q    E++R++REE    Q   +E +R  E ++   LE+E+ +  
Sbjct: 1711 QEE-----------QQLRRQELERKFREEEQLRQETEQEQLRRQE-RYRKILEEEQLRPE 1758

Query: 145  QYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTE 204
            +  +   R+  D + R  E   +E  E +++  + D +      +  E+E   L+ +  +
Sbjct: 1759 REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRD 1818

Query: 205  AEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCH 264
             + + +E E  +++E    L  E+  +   E   A             EK R+E  E+  
Sbjct: 1819 GKYRWEE-EQLQLEEQEQRLRQERDRQYRAEEQFAT-----------QEKSRREEQELWQ 1866

Query: 265  LLEQERQQHNQLKHTWQKANDQFLESQR 292
              EQ+R+Q  + K   +    Q  E QR
Sbjct: 1867 EEEQKRRQERERKLREEHIRRQQKEEQR 1894



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 69/323 (21%), Positives = 147/323 (45%), Gaps = 37/323 (11%)

Query: 547  QIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQAS 606
            Q+++   R   ++ QL+  +   QL +  +D++ LE+  +   ++   +     LR+Q  
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP 1513

Query: 607  EILLEELQQGLSQAKRD---VQEQMAVLMQSR-EQVSEELVRLQKDNDSL-QGKHSLHVS 661
            E    E +Q L + +R    +QE+  +  Q R +Q  ++  R  ++ + L Q +    +S
Sbjct: 1514 ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573

Query: 662  LQQAE-DFILPDTTEALRELVLKYREDIINVR------TAADHVEEKLKAEILFLKE--- 711
             Q+ +  F L +     +E   K+ ED   +R            + K + +   L+E   
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633

Query: 712  -QIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLE 770
             Q+  ++  ++ LEE  QL  +  ++++      K   E   +++G+ E  LR + +  +
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE-EQQLRRQERDRK 1692

Query: 771  SLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQV 830
              +E     E+QL+++   +  +++   E++ + Q L+ +    EQ+++      +T Q 
Sbjct: 1693 FREE-----EQQLRRQERERKFLQE---EQQLRRQELERKFREEEQLRQ------ETEQE 1738

Query: 831  QLERIRQADSLERIRAILNDTKL 853
            QL R       ER R IL + +L
Sbjct: 1739 QLRR------QERYRKILEEEQL 1755



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 60/286 (20%), Positives = 120/286 (41%), Gaps = 34/286 (11%)

Query: 540  EKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL 599
            E++ Q +  QE + +   ++ QL  ++   QL      K   E+ + Q  E+        
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ------ 1683

Query: 600  VLRAQASEILLEELQQGLSQAKRD---VQEQMAVLMQSREQVSEELVRLQKDNDSLQGKH 656
             LR Q  +    E +Q L + +R+   +QE+  +  Q  E+   E  +L+++ +  Q + 
Sbjct: 1684 -LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742

Query: 657  SLHVSLQQAEDFILPDTTEAL---RELVLKYREDIINVRTAADHVEEKLKAEILFLKEQI 713
                     E+ + P+  E     +E   K+RE            EE+L+ E    +EQ 
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKFRE------------EEQLRQE---REEQQ 1787

Query: 714  QAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQ 773
               Q       E  QL  E  ++++      +    + + E+ QL+  L E+ Q+L   +
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRP----QQRDGKYRWEEEQLQ--LEEQEQRLRQER 1841

Query: 774  EIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQR 819
            + +   EEQ   +  ++   ++L  EE+ K ++ +      E ++R
Sbjct: 1842 DRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR 1887


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  100 bits (249), Expect = 6e-21
 Identities = 181/872 (20%), Positives = 362/872 (41%), Gaps = 151/872 (17%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAK---EEDLKRQNAVLQAAQDDL 71
            + +V  L KINA+  +    LE    Q++    +L  AK   E DLK     +   ++D 
Sbjct: 1018 EDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDK 1077

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
              +  +L + + E+  ++A          E +  +  Q+++++  LQA ++E   + E +
Sbjct: 1078 QQIEEKLKKKEFELSQLQA------KIDDEQVHSL--QFQKKIKELQARIEELEEEIEAE 1129

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQE-DAEKLRSVVMP 190
              LR + E+      R    RE+ ++  RL E     + + EM K +E + +K+R     
Sbjct: 1130 HTLRAKIEKQ-----RSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRR---- 1180

Query: 191  MEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQE 250
             + E A L+ + T A   +++ +A  V EL   ++               L   K  L++
Sbjct: 1181 -DLEEATLQHEATAAT--LRKKQADSVAELGEQIDN--------------LQRVKQKLEK 1223

Query: 251  DAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLE------SQRLLMRDMQRMEIV 304
            +  +L+ E+ ++   +E   +  + ++ T +   DQF E       Q  L+ D+   +  
Sbjct: 1224 EKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKAR 1283

Query: 305  LTSEQLRQVEELKKKD----QEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ 360
            L ++       +++K+    Q    +Q L ++ +  K  +EEE K     A   + S   
Sbjct: 1284 LQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHD 1343

Query: 361  LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420
                 E  +  + +   L   L        SK+++++ +   R    TD++  +  L+  
Sbjct: 1344 CDLLREQYEEEQEAKAELQRAL--------SKANSEVAQ--WRTKYETDAIQRTEELEEA 1393

Query: 421  ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTAS--LGSLQMPSGFM------LTKDQ 472
                  K K A  L E++           EN +TA+    SL+     +      L +D 
Sbjct: 1394 ------KKKLAQRLQEAE-----------ENTETANSKCASLEKTKQRLQGEVEDLMRDL 1436

Query: 473  ER---AIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKL 529
            ER   A   +  +Q     +L+   Q ++            S+ E    QKE  +   +L
Sbjct: 1437 ERSHTACATLDKKQRNFDKVLAEWKQKLDE-----------SQAELEAAQKESRSLSTEL 1485

Query: 530  GRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSS 589
             +   M + YE+ +  ++    E     K LQ  +    +Q+ +T K+ QE E   K   
Sbjct: 1486 FK---MRNAYEEVVDQLETLRREN----KNLQEEISDLTEQIAETGKNLQEAEKTKKLVE 1538

Query: 590  EDSSHQISALV-----LRAQASEILLEELQQGLSQAKRDVQ-------EQMAVLMQSREQ 637
            ++ S    AL      L  + S+IL  +L+  LSQ K ++        E++  L ++ ++
Sbjct: 1539 QEKSDLQVALEEVEGSLEHEESKILRVQLE--LSQVKSELDRKVIEKDEEIEQLKRNSQR 1596

Query: 638  VSEEL-----VRLQKDNDSLQGKHSLHVSLQQAEDFI------LPDTTEALRELVLKYRE 686
             +E L       ++  ND+L+ K  +   L + E  +      + +T + LR +  + ++
Sbjct: 1597 AAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKD 1656

Query: 687  DIINVRTAADHVEEKLKAEILFLK-------EQIQAEQCLKENLEETLQLEIENCKEEIA 739
              +++  A     E LK ++  ++       E+++  +   E  E T +L  +   +   
Sbjct: 1657 SQLHLDDAL-RSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715

Query: 740  SISSLKAELERIKVEKGQLESTLREKSQQLE-SLQEIKISLE-------------EQLKK 785
             +  L ++   +   K +LE+ + +   ++E S+QE + + E             E+LKK
Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKK 1775

Query: 786  ETAAKATVEQLMFEEKNKAQRLQTELDVSEQV 817
            E    A +E++    +   + LQ  LD +EQ+
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 187/903 (20%), Positives = 370/903 (40%), Gaps = 150/903 (16%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDL- 71
            +L + +  LE+ N   L  +++  QE +Q+     ++   K   L + NA L+   DDL 
Sbjct: 981  NLSEEMTALEE-NISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLE 1039

Query: 72   ------GHLRTQLWEAQAEMENIKAIATVS----ENTKQEAIDEVKR------------- 108
                    LR  L  A+ ++E    ++  S    EN KQ+  +++K+             
Sbjct: 1040 GSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKID 1099

Query: 109  -------QWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRL 161
                   Q+++++  LQA ++E   + E +  LR + E+      R    RE+ ++  RL
Sbjct: 1100 DEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEK-----QRSDLARELEEISERL 1154

Query: 162  SEGQEEENLENEM-KKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKEL 220
             E     + + EM KK + + +K+R      + E A L+ + T A   +++ +A  V EL
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMR-----RDLEEATLQHEATAA--TLRKKQADSVAEL 1207

Query: 221  NHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTW 280
               ++               L   K  L+++  +L+ E+ ++   +E   +  + ++ T 
Sbjct: 1208 GEQIDN--------------LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTC 1253

Query: 281  QKANDQFL------ESQRLLMRDMQRMEIVLTSEQLRQVEELKKKD----QEDDEQQRLN 330
            +   DQF       E Q  L+ D+   +  L ++       +++K+    Q    +Q L 
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT 1313

Query: 331  KRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPF 390
            ++ +  K  +EEE K     A   + S        E  +  + +   L   L        
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRAL-------- 1365

Query: 391  SKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSE 450
            SK+++++ +   R    TD++  +  L+        K K A  L E++           E
Sbjct: 1366 SKANSEVAQ--WRTKYETDAIQRTEELEEA------KKKLAQRLQEAE-----------E 1406

Query: 451  NFDTAS--LGSLQMPSGFM------LTKDQER---AIKAMTPEQEETASLLSSVTQGMES 499
            N +TA+    SL+     +      L +D ER   A   +  +Q     +L+   Q ++ 
Sbjct: 1407 NTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDE 1466

Query: 500  AYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKK 559
                       S+ E    QKE  +   +L +   M + YE+ +  ++    E     K 
Sbjct: 1467 -----------SQAELEAAQKESRSLSTELFK---MRNAYEEVVDQLETLRREN----KN 1508

Query: 560  LQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL-----VLRAQASEILLEELQ 614
            LQ  +    +Q+ +T K+ QE E   K   ++ S    AL      L  + S+IL  +L+
Sbjct: 1509 LQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLE 1568

Query: 615  QGLSQAKRDV-------QEQMAVLMQSREQVSEEL-----VRLQKDNDSLQGKHSLHVSL 662
              LSQ K ++        E++  L ++ ++ +E L       ++  ND+L+ K  +   L
Sbjct: 1569 --LSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626

Query: 663  QQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQI----QAEQC 718
             + E   L  +   + E     R     ++ +  H+++ L++    LKEQ+    +    
Sbjct: 1627 NEME-IQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSN-EDLKEQLAIVERRNGL 1684

Query: 719  LKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKIS 778
            L E LEE      +  +    S   L    +R+++   Q  S +  K +    + + +  
Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAE 1744

Query: 779  LEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQA 838
            +E  +++   A+   ++ + +    A+ L+ E D S  ++R    L QT++    R+ +A
Sbjct: 1745 VENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 1804

Query: 839  DSL 841
            + L
Sbjct: 1805 EQL 1807



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 168/821 (20%), Positives = 339/821 (41%), Gaps = 113/821 (13%)

Query: 80   EAQAEMENIKAIATVSENTKQE-AIDEVKRQWREE--VASLQAVMKETVRDYEHQFHLRL 136
            EA+ EM  +K      E TK+E A  E +R+  EE  V+ LQ      ++      +L  
Sbjct: 848  EAEKEMATMKEDF---ERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMD 904

Query: 137  EQERTQWA-QYRESAEREIADLRRRLSEGQE--------EENLENEMKKAQEDAEKLRSV 187
             +ER +   + +   E ++ +L  RL E +E        + NLE++    + D + L   
Sbjct: 905  AEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELT 964

Query: 188  VMPMEKEIAALKDKLTEAEDKIKELE---ASKVKELNHYLEAEKSCRTDLEMYVAVLNTQ 244
            +  +EKE  A ++K+    +++  LE   +   KE     EA +    DL++    +N  
Sbjct: 965  LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVN-- 1022

Query: 245  KSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM---RDMQRM 301
              +++ +A KL ++  ++   LEQE++    L+   +K       SQ  +M    D Q++
Sbjct: 1023 -GLIKINA-KLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQI 1080

Query: 302  EIVLTSEQLRQVEELKKKDQE--------DDEQ------QRLNKRKDHKKADVEEEIKIP 347
            E           E+LKKK+ E        DDEQ      Q+  K    +  ++EEEI+  
Sbjct: 1081 E-----------EKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE 1129

Query: 348  VVCALTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLR 403
                   E+  + L+ E     E L+   G+  S    +       F K   D+ +  L+
Sbjct: 1130 HTLRAKIEKQRSDLARELEEISERLEEASGAT-SAQIEMNKKREAEFQKMRRDLEEATLQ 1188

Query: 404  RAQSTDSLGTSGSLQSKALG--YNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQ 461
               +  +L    +     LG   +   +    L++      +  D ++ N +  S     
Sbjct: 1189 HEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSN 1248

Query: 462  MPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKE 521
            +       +DQ   IKA   +Q +                            + N+ +  
Sbjct: 1249 IERTCRTVEDQFSEIKAKDEQQTQLIH-------------------------DLNMQKAR 1283

Query: 522  VHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETR-DQVKKLQLMLRQANDQLEKTMKDKQE 580
            +     +L  R               ++E E+   Q+ K +  L Q  ++L++ M+++ +
Sbjct: 1284 LQTQNGELSHR---------------VEEKESLISQLTKSKQALTQQLEELKRQMEEETK 1328

Query: 581  LEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSE 640
             ++ +  + + S H    L  + +  +    ELQ+ LS+A  +V +          Q +E
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTE 1388

Query: 641  EL--------VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYR--EDIIN 690
            EL         RLQ+  ++ +  +S   SL++ +  +  +  + +R+L   +     +  
Sbjct: 1389 ELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDK 1448

Query: 691  VRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIA-SISSLKAELE 749
             +   D V  + K ++   + +++A Q    +L   L  ++ N  EE+   + +L+ E +
Sbjct: 1449 KQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEL-FKMRNAYEEVVDQLETLRRENK 1507

Query: 750  RIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQT 809
             ++ E   L   + E  + L+  ++ K  +E++      A   VE  +  E++K  R+Q 
Sbjct: 1508 NLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL 1567

Query: 810  EL-DVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILN 849
            EL  V  ++ R  ++  + ++ QL+R  Q  + E ++++L+
Sbjct: 1568 ELSQVKSELDRKVIEKDEEIE-QLKRNSQR-AAEALQSVLD 1606



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 183/891 (20%), Positives = 363/891 (40%), Gaps = 88/891 (9%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQ---QLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQ 65
            Q +  L+++  EL ++ A+    Q    Q +++  + +A+ +EL    EE+++ ++ +  
Sbjct: 1079 QIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEEL----EEEIEAEHTLRA 1134

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAI--ATVSENTKQEAIDEVKRQWREEVASLQAVMKE 123
              +     L  +L E    +E       A +  N K+EA  +  R+  EE          
Sbjct: 1135 KIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEK 183
            T+R  +      L ++     + ++  E+E ++L+  + +     N+E  + K++ + E+
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDD--MASNIE-ALSKSKSNIER 1251

Query: 184  LRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVK------ELNHYLEAEKSCRTDLEMY 237
                V     EI A  ++ T+    I +L   K +      EL+H +E ++S  + L   
Sbjct: 1252 TCRTVEDQFSEIKAKDEQQTQL---IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKS 1308

Query: 238  VAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRD 297
               L  Q   L+   E+  K  + + H L+  R   + L+  +++  +   E QR L + 
Sbjct: 1309 KQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKA 1368

Query: 298  MQRMEIVLTS------EQLRQVEELKKKD----QEDDEQQR--------LNKRKDHKKAD 339
               +    T       ++  ++EE KKK     QE +E           L K K   + +
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGE 1428

Query: 340  VEEEIK----IPVVCALT---QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSK 392
            VE+ ++        CA     Q      L+  ++ LD ++           L +    S+
Sbjct: 1429 VEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAE---------LEAAQKESR 1479

Query: 393  S-DNDMFKDGLRRAQSTDSLGT----SGSLQSKALGYNYKAKSAG-NLDESDFGPLVGAD 446
            S   ++FK      +  D L T    + +LQ +      +    G NL E++        
Sbjct: 1480 SLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAE-----KTK 1534

Query: 447  SVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSG 506
             + E   +    +L+   G  L  ++ + ++      +  + L   V +  E        
Sbjct: 1535 KLVEQEKSDLQVALEEVEG-SLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRN 1593

Query: 507  YRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQ 566
             +  +E   ++L  E+ +  + L  +  M    E  L  ++IQ   +  Q+ + Q  LR 
Sbjct: 1594 SQRAAEALQSVLDAEIRSRNDALRLKKKM----EGDLNEMEIQLGHSNRQMAETQKHLRT 1649

Query: 567  ANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQE 626
               QL    KD Q   D   +S+ED   Q++ +  R   + +LLEEL++ +  A    + 
Sbjct: 1650 VQGQL----KDSQLHLDDALRSNEDLKEQLAIVERR---NGLLLEELEE-MKVALEQTER 1701

Query: 627  QMAVLMQSREQVSEELVRLQKDNDSL-QGKHSLHVSLQQAEDFILPDTTEALRELVLKYR 685
               +  Q     S+ +  L   N SL   K  L   + Q +  +     E+ R    K +
Sbjct: 1702 TRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQES-RNAEEKAK 1760

Query: 686  EDIINVRTAADHV--EEKLKAEILFLKEQI-QAEQCLKENLEETLQLEIENCKEEIASIS 742
            + I +    A+ +  E+   A +  +K+ + Q  + L+  L+E  QL ++  K++I  + 
Sbjct: 1761 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1820

Query: 743  SLKAELE-RIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEK 801
            +   ELE  + VE+ +    L+   +    ++E+    EE  K     +  V++L  + K
Sbjct: 1821 NRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVK 1880

Query: 802  N-KAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS-LERIRAILND 850
            + K Q  + E   + Q+ R   ++   L+   ER   A+S + ++RA   D
Sbjct: 1881 SYKRQAEEAEEQANTQLSR-CRRVQHELEEAAERADIAESQVNKLRAKSRD 1930



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 70/340 (20%), Positives = 152/340 (44%), Gaps = 62/340 (18%)

Query: 540  EKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSE---DSSHQI 596
            EK++  ++     T++++ + +   ++  +++   +++K +L+  ++  +E   D+  + 
Sbjct: 850  EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC 909

Query: 597  SALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQ--- 653
              L+     S+ILLE   + L++   + +E  + L+  +  + ++   L++D D L+   
Sbjct: 910  EGLI----KSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTL 965

Query: 654  -----GKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV-------EEK 701
                  KH+    ++      L +   AL E + K  ++  +++ A           E+K
Sbjct: 966  TKVEKEKHATENKVKN-----LSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDK 1020

Query: 702  LKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLEST 761
            +   I    +  Q    L+ +LE+                  L+A+LER    K +LE  
Sbjct: 1021 VNGLIKINAKLEQQTDDLEGSLEQE---------------KKLRADLER---AKRKLEGD 1062

Query: 762  LREKSQQLESLQEIKISLEEQLKK------ETAAKATVEQ---LMFEEKNKAQRLQTELD 812
            L+   + +  L+  K  +EE+LKK      +  AK   EQ   L F++K K  + + E +
Sbjct: 1063 LKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIE-E 1121

Query: 813  VSEQVQRDFVKLSQTLQVQLERIRQ--ADSLERIRAILND 850
            + E+++ +      TL+ ++E+ R   A  LE I   L +
Sbjct: 1122 LEEEIEAE-----HTLRAKIEKQRSDLARELEEISERLEE 1156



 Score = 35.8 bits (81), Expect = 0.18
 Identities = 36/133 (27%), Positives = 60/133 (45%), Gaps = 14/133 (10%)

Query: 707 LFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKV----EKGQLESTL 762
           LF K +   +    E    T++ + E  KEE+A   + + ELE   V    EK  L+  +
Sbjct: 836 LFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQV 895

Query: 763 REKSQQL-------ESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSE 815
           + +++ L       E L + KI LE ++K+ T      E++  E   K + L+   D   
Sbjct: 896 QSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLE---DKCS 952

Query: 816 QVQRDFVKLSQTL 828
            ++RD   L  TL
Sbjct: 953 SLKRDIDDLELTL 965


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  100 bits (248), Expect = 8e-21
 Identities = 189/840 (22%), Positives = 352/840 (41%), Gaps = 146/840 (17%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKR---QNAVLQAAQDDL 71
            +  V +  ++  E  R+ +QLEQ   ++    KEL   +E  L R   Q  +LQA + ++
Sbjct: 648  EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREA-LSRATLQRDMLQAEKAEV 706

Query: 72   GHLRTQLWEAQAEME---------------NIKAIATVSENTKQEAID--EVKRQWREEV 114
                T+    + E+E               ++  ++ ++E+  Q+ +D   +  Q  EE 
Sbjct: 707  AEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEK 766

Query: 115  ASL-----QAVMKETV--RDYEHQFHLRLEQERTQWA---------QYRESAEREIADLR 158
            ++L     QA  + TV   + E    LRLEQE  +           Q +E+ E+++  LR
Sbjct: 767  SALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLR 826

Query: 159  RRLSEGQE------------EENLENEMKKAQEDAEKLRSVVMPME---KEIAALKDKLT 203
               S+ QE            E+ LE   ++AQ   E L       E   KE A L  +L 
Sbjct: 827  HERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV 886

Query: 204  EAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVC 263
             AE + + L + +   L    EA +    +++  +A L  ++  L+ + + L      + 
Sbjct: 887  AAEREGRTL-SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLT 945

Query: 264  HLLEQERQQHNQLKHTWQKAN-DQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQE 322
              L   RQ   Q+  T +KA+ D+ L +Q+L+            +E+  Q    +++   
Sbjct: 946  GELAGLRQ---QIIATQEKASLDKELMAQKLVQ-----------AEREAQASLREQRAAH 991

Query: 323  DDEQQRLNKRKDHKKADVE-EEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSV-HSLDA 380
            +++ QRL + K+    ++E E  ++       QEE  A+L  E+E L     ++    D 
Sbjct: 992  EEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE 1051

Query: 381  GLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFG 440
            GLLL   +   K      K+  + A S   +GT  SL + +L    + + A +  E D  
Sbjct: 1052 GLLLAESE---KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRS 1108

Query: 441  PLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPE----QEETASLLSSVTQG 496
             +        N  T+ L  L+          +E A  A   E    QE+   L       
Sbjct: 1109 TV--------NALTSELRDLR--------AQREEAAAAHAQEVRRLQEQARDLGKQRDSC 1152

Query: 497  MESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQ 556
            +  A    +  RL+ +   + L++E+  A  KL           +  +G ++Q  E  + 
Sbjct: 1153 LREAEELRTQLRLLEDAR-DGLRRELLEAQRKL----------RESQEGREVQRQEAGEL 1201

Query: 557  VKKL------QLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL-----VLRAQA 605
             + L      +  LR++N++L   +K  +     +K ++ED   +++ L      +  +A
Sbjct: 1202 RRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEA 1261

Query: 606  SEIL--LEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ 663
             E+   L+E+++   +A+R++QE    L +  + +  E  RL ++   LQG+ +L    +
Sbjct: 1262 GELRTGLQEVERSRLEARRELQE----LRRQMKMLDSENTRLGRELAELQGRLALG---E 1314

Query: 664  QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLK--------AEILFLKEQIQA 715
            +AE     +T   LR+ +LK    +  +R      + KL+         E   L    +A
Sbjct: 1315 RAEKESRRETL-GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA 1373

Query: 716  EQCLKENLEET--LQLEIENCKEEIASI-----------SSLKAELERIKVEKGQLESTL 762
                K+ L+    L+L++E  + E A +             L+AEL R++V++   E+ L
Sbjct: 1374 RGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQL 1433



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 176/825 (21%), Positives = 322/825 (39%), Gaps = 98/825 (11%)

Query: 29  LRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDL-------GHLRTQLWEA 81
           +R   +L ++  +++A ++    A +E  +RQ  ++Q  Q  +         L  QL E 
Sbjct: 138 VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLER 197

Query: 82  QAEMENIKAIATVSENTKQEAID--EVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQE 139
             E+E  +   T      + A+   E ++Q    +A + A+++E + D     +  L ++
Sbjct: 198 SGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQL-DQAGSANQALSED 256

Query: 140 ----RTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEI 195
                  W + R+  E   A  RR      EEE+              L   V+   + +
Sbjct: 257 IRKVTNDWTRCRKELEHREAAWRR------EEESFNAYFSNEHSRLLLLWRQVVGFRRLV 310

Query: 196 AALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV----AVLNTQKSVLQED 251
           + +K   TE +  + +L     +      EA     T L +      A L  Q  +  + 
Sbjct: 311 SEVK-MFTERD--LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQL 367

Query: 252 AEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLT-SEQL 310
            E+LR ++     L +Q+ Q          +  +  L  +RL  +++++ ++    +E+L
Sbjct: 368 EEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKL 427

Query: 311 RQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDS 370
             +E L+ ++Q   E +            +++ ++      L+  ES  QLS  E   D+
Sbjct: 428 EALESLRLQEQAALETE--------DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADA 479

Query: 371 TRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKS 430
           + GS+  L +G   PS    S            R +S     +     S  L   + A  
Sbjct: 480 SNGSLRGL-SGQRTPSPPRRSSPG---------RGRSPRRGPSPACSDSSTLALIHSALH 529

Query: 431 AGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLL 490
              L   D   + G    S++     LG+L+         D E   +A+  + +      
Sbjct: 530 KRQLQVQD---MRGRYEASQDL----LGTLRKQ-----LSDSESERRALEEQLQRLRDKT 577

Query: 491 SSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQE 550
               Q  E A       R  +E    LL +E               SN    LQ  Q Q 
Sbjct: 578 DGAMQAHEDAQREVQRLRSANE----LLSREK--------------SNLAHSLQVAQQQA 619

Query: 551 AETRDQVKKLQLM---LRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASE 607
            E R + +KLQ     LR+  D+LE+  +D  +    +++  E S  Q+  L  +     
Sbjct: 620 EELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLA 679

Query: 608 ILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAED 667
             L E+++ LS+A      Q  +L   + +V+E L + +     L+    L ++  +AE+
Sbjct: 680 KELVEVREALSRATL----QRDMLQAEKAEVAEALTKAEAGRVELE----LSMTKLRAEE 731

Query: 668 FILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETL 727
             L D+   L  L     +D +++      +EE+  A       Q QAEQ      EE  
Sbjct: 732 ASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSA---LQGRQRQAEQEATVAREEQE 788

Query: 728 QLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKET 787
           +LE    ++E+A    L+  L   +  +  LE       QQL +L+  +  L+EQL + +
Sbjct: 789 RLEELRLEQEVAR-QGLEGSLRVAEQAQEALE-------QQLPTLRHERSQLQEQLAQLS 840

Query: 788 AAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQL 832
              +  EQ + + + +AQR    L+ + + +    K    L VQL
Sbjct: 841 RQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQL 885



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 209/970 (21%), Positives = 385/970 (39%), Gaps = 159/970 (16%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            QQ +A  EK + +     Q+L Q   + +A  +E   A EEDL+R     +AA  +L   
Sbjct: 953  QQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAE 1012

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVK--RQWREEVASL--------------- 117
            R QL ++Q + E  + +A + E  K+E  +E+   +Q R+E   L               
Sbjct: 1013 RAQL-QSQLQREQEELLARL-EAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESE 1070

Query: 118  QAVMKETVRDYEHQFH-LRLEQERTQW-AQYRESAER--------EIADLRRRLSEG--- 164
            +  + E +    H    + LE ER +  AQ R+  +R        E+ DLR +  E    
Sbjct: 1071 KTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAA 1130

Query: 165  ---------QEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKE---- 211
                     ++  +L  +      +AE+LR+ +  +E     L+ +L EA+ K++E    
Sbjct: 1131 HAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEG 1190

Query: 212  --LEASKVKELNHYL-----EAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCH 264
              ++  +  EL   L     E E   R++ E+  AV   +   +        KE  +   
Sbjct: 1191 REVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKE--QKLA 1248

Query: 265  LLEQER----QQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKK-- 318
            LLE+ R    ++  +L+   Q+     LE++R L ++++R   +L SE  R   EL +  
Sbjct: 1249 LLEEARTAVGKEAGELRTGLQEVERSRLEARREL-QELRRQMKMLDSENTRLGRELAELQ 1307

Query: 319  -------KDQEDDEQQRLNKRKDHKKADVEEEI---KIPVVCALTQEESSA--------- 359
                   + +++  ++ L  R+   K +   E+   ++ V     QE+            
Sbjct: 1308 GRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLL 1367

Query: 360  -----QLSNEEEHLDSTRGSVHSLDA--------GLLLPSGDPFSKS-DNDMFKDGLRRA 405
                     E++ LD  RG    L+A        GL L + +  ++  + ++ +  ++R 
Sbjct: 1368 GSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR 1427

Query: 406  QSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASL-----GSL 460
             +   LG   S   + LG       A             A+   E  ++ S      GS 
Sbjct: 1428 AAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGS- 1486

Query: 461  QMPSGFMLTK------DQERAIKAMTPEQEETASL------LSSVTQGMESAYVSPSGYR 508
            Q PS    T       D E    A+    +E  S       L + T  +          R
Sbjct: 1487 QPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAER 1546

Query: 509  LVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQAN 568
              + +    LQK V  A ++  RR     + + +L G+Q + A   + V++ +   R   
Sbjct: 1547 DSATSRARQLQKAV--AESEEARR-----SVDGRLSGVQAELALQEESVRRSERERRATL 1599

Query: 569  DQLEKTMKDKQELEDFIKQSSEDSSHQ-----------------ISALVLRAQASEILLE 611
            DQ+    +  Q  E  ++ S E  S                   + A   R    E+   
Sbjct: 1600 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR 1659

Query: 612  ELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILP 671
             L+  L +++  + ++ A     +++V + L R   D++   G   L V         + 
Sbjct: 1660 SLEGELQRSRLGLSDREAQAQALQDRV-DSLQRQVADSEVKAGTLQLTVERLNGALAKVE 1718

Query: 672  DTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEI 731
            ++  ALR+ V    E +     + +   +K     L L++ + A +  ++ L+E L    
Sbjct: 1719 ESEGALRDKVRGLTEALAQSSASLNSTRDKN----LHLQKALTACEHDRQVLQERLDAAR 1774

Query: 732  ENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKA 791
            +   E     SSL  +++ ++ E   LE    E   QL+ L+E+   L ++ + E AA  
Sbjct: 1775 QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREV---LRQRQEGEAAALN 1831

Query: 792  TVEQLMFEEKNKAQRL--------QTELDVSE------QVQRDFVKLSQTL-QVQLERIR 836
            TV++L  E +   +RL        Q E +  E      ++++D V L +TL +V+ E++R
Sbjct: 1832 TVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLR 1891

Query: 837  QADSLERIRA 846
              +   R+ A
Sbjct: 1892 SHEDTVRLSA 1901



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 158/810 (19%), Positives = 331/810 (40%), Gaps = 103/810 (12%)

Query: 84  EMENIKAIATVSENTKQEA--IDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT 141
           EM ++ ++   ++  +QE   ++++  Q R E   L A+    V +   Q  LRLE    
Sbjct: 72  EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDEL-AIKYNAVSERLEQA-LRLEPGEL 129

Query: 142 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK 201
           +  + R    R+  +LRR+L E  E+ +   +++  QE  ++   +V  ++ +I   K +
Sbjct: 130 ETQEPR-GLVRQSVELRRQLQE--EQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKR 186

Query: 202 LTEAEDKIKE----LEASKVKELNHY---------LEAEKSCRTDLEMYVAVLNTQKSVL 248
            +E E ++ E    LE  ++++  H          LE E+     L    A+L  Q    
Sbjct: 187 CSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQA 246

Query: 249 QEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFL-----ESQRLLM-------- 295
               + L +++ +V +   + R++    +  W++  + F      E  RLL+        
Sbjct: 247 GSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGF 306

Query: 296 ------------RDMQRM--EIVLTSEQLRQVE---ELKKKDQEDDEQQRLNKRKDHKKA 338
                       RD+ ++  E+  TS  +++         +  E   +  L K+    +A
Sbjct: 307 RRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQA-LLQA 365

Query: 339 DVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMF 398
            +EE+++  V+    +E+  AQ   + + LD    S    + GL +   +  +   + + 
Sbjct: 366 QLEEQLRDKVL----REKDLAQQQMQSD-LDKADLSARVTELGLAVKRLEKQNLEKDQVN 420

Query: 399 KDGLRRAQSTDSLGTSGSL-----QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFD 453
           KD   + ++ +SL             + L    +  +   L +S+ G  +   S SE   
Sbjct: 421 KDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQL---SGSERTA 477

Query: 454 TASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSET 513
            AS GSL+  SG           +  +P +  +     S  +G   A    S   L+  +
Sbjct: 478 DASNGSLRGLSGQ----------RTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALI-HS 526

Query: 514 EWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEK 573
             +  Q +V +   +     D+     KQL   + +     +Q+++L+     A    E 
Sbjct: 527 ALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586

Query: 574 TMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEE------LQQGLSQAKRDVQEQ 627
             ++ Q L    +  S + S+   +L +  Q +E L +E       Q+ L + +  ++E+
Sbjct: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646

Query: 628 MAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYRED 687
               +Q   +V  EL R  +  + L+GK S+                  L + +++ RE 
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSV------------------LAKELVEVREA 688

Query: 688 IINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAE 747
           +       D ++ + KAE+     + +A +   E     L+ E  + ++ ++ +S+L   
Sbjct: 689 LSRATLQRDMLQAE-KAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNES 747

Query: 748 LERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRL 807
           L + K++  +L + L E+   L+  Q      E++       +  +E+L  E++   Q L
Sbjct: 748 LAQDKLDLNRLVAQLEEEKSALQGRQR---QAEQEATVAREEQERLEELRLEQEVARQGL 804

Query: 808 QTELDVSEQVQRDFVKLSQTLQVQLERIRQ 837
           +  L V+EQ Q    +   TL+ +  ++++
Sbjct: 805 EGSLRVAEQAQEALEQQLPTLRHERSQLQE 834



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 170/810 (20%), Positives = 324/810 (40%), Gaps = 98/810 (12%)

Query: 22   EKINAEFLRAQQQLEQEFNQK--RAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLW 79
            +K+  E   AQQQ++ + ++    A+  EL LA +  L++QN        DL   + +  
Sbjct: 373  DKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKR-LEKQNLEKDQVNKDLTE-KLEAL 430

Query: 80   EAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQE 139
            E+    E         E  +Q   D  +    +  + +Q    E   D  +     L  +
Sbjct: 431  ESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQ 490

Query: 140  RTQWAQYRESAEREIADLRR---RLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIA 196
            RT     R S  R  +  R      S+      + + + K Q   + +R      +  + 
Sbjct: 491  RTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLG 550

Query: 197  ALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLR 256
             L+ +L+++E + + LE    ++L    +     +TD  M             EDA++  
Sbjct: 551  TLRKQLSDSESERRALE----EQLQRLRD-----KTDGAMQA----------HEDAQREV 591

Query: 257  KELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEEL 316
            + L     LL +E+   + L H+ Q A  Q  E ++      +R ++    E+LR+  + 
Sbjct: 592  QRLRSANELLSREK---SNLAHSLQVAQQQAEELRQ------EREKLQAAQEELRRQRDR 642

Query: 317  KKKDQEDDEQQRLNKRKD----HKKADVEEEIKIPVVCALTQ-EESSAQLSNEEEHLDST 371
             +++QED  Q     R++    H++ +  E  +  +   L +  E+ ++ + + + L + 
Sbjct: 643  LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAE 702

Query: 372  RGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSA 431
            +  V    A  L  +     + +  M K     A   DSL    +L              
Sbjct: 703  KAEV----AEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQ-------- 750

Query: 432  GNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLS 491
               D+ D   LV    + E          Q      + ++++  ++ +  EQE       
Sbjct: 751  ---DKLDLNRLVA--QLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR---- 801

Query: 492  SVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEA 551
               QG+E       G   V+E     L++++    ++  +  +  +   +QL G + +  
Sbjct: 802  ---QGLE-------GSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELE 851

Query: 552  ETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDS---SHQISALVLRAQASEI 608
            + R + ++    L +A  + E   K+   L   +  +  +    S + + L L  +A E 
Sbjct: 852  QARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEG 911

Query: 609  LLEELQQGLSQ--AKRD-VQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-- 663
             L E+Q+ L+Q  A+R+ ++ +   L+ ++E ++ EL  L++   + Q K SL   L   
Sbjct: 912  SLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQ 971

Query: 664  ---QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK 720
               QAE     +   +LRE    + ED+  ++   +    +L+AE   L+ Q+Q EQ   
Sbjct: 972  KLVQAER----EAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQ--- 1024

Query: 721  ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE 780
            E L   L+ E E   EEIA++   + E          L     EK Q L   +  K +L 
Sbjct: 1025 EELLARLEAEKEELSEEIAALQQERDE---------GLLLAESEKQQALSLKESEKTALS 1075

Query: 781  EQLKKETAAKATVEQLMFEEKNKAQRLQTE 810
            E+L     + AT+   M  +K  AQ  Q +
Sbjct: 1076 EKLMGTRHSLATISLEMERQKRDAQSRQEQ 1105



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 175/909 (19%), Positives = 345/909 (37%), Gaps = 140/909 (15%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQEFN---QKRAKFKELYLAKE---EDLKRQN 61
            +Q  + L + VA+LE+  +     Q+Q EQE     +++ + +EL L +E   + L+   
Sbjct: 749  AQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSL 808

Query: 62   AVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVM 121
             V + AQ+ L      L   +++++   A  +   + +++ +++ +R+ + +V +L+   
Sbjct: 809  RVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAA 868

Query: 122  KETVRDYEHQFHLR------------LEQERTQWAQYRESAEREIADLRRRLSEGQEEEN 169
            +E     +    L             L +E T+    +E+ E  + +++R+L++      
Sbjct: 869  REKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ------ 922

Query: 170  LENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKI---KELEASKVKELNHYLEA 226
            LE   ++ + + + L      +  E+A L+ ++   ++K    KEL A K+      ++A
Sbjct: 923  LEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKL------VQA 976

Query: 227  EKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQ 286
            E+  +       A L  Q++  +ED ++L++E       LE ER Q              
Sbjct: 977  EREAQ-------ASLREQRAAHEEDLQRLQREKEAAWRELEAERAQ-------------- 1015

Query: 287  FLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDE---------QQRLNKRKDHKK 337
             L+SQ  L R+ + +   L +E+    EE+    QE DE         QQ L+ ++  K 
Sbjct: 1016 -LQSQ--LQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKT 1072

Query: 338  ADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM 397
            A  E+ +      A    E   Q  + +   +  R +V++L + L     D  ++ +   
Sbjct: 1073 ALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSEL----RDLRAQREEAA 1128

Query: 398  FKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASL 457
                    +  +     G  +   L    + ++   L E         D +      A  
Sbjct: 1129 AAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLED------ARDGLRRELLEAQR 1182

Query: 458  GSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLV------- 510
               +   G  + + +   ++    E  +    L    + + SA       R+        
Sbjct: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1242

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
             E +  LL++     G + G         E+     + +  E R Q+K    ML   N +
Sbjct: 1243 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK----MLDSENTR 1298

Query: 571  LEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAV 630
            L + + + Q      +++ ++S  +   L  R    E  LE ++Q L  A+R +QEQ   
Sbjct: 1299 LGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGE 1358

Query: 631  LMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIIN 690
              ++RE+      RL    +  +G     +   +  +  L        EL L+       
Sbjct: 1359 -FRTRER------RLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRL------ 1405

Query: 691  VRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEI------------------- 731
              +AA+   + L+AE+  ++ Q +A +     L   L+  +                   
Sbjct: 1406 --SAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPAR 1463

Query: 732  ----ENCKEEIASISSLKAELERIKVEKGQLES-------------TLREKSQQLESLQE 774
                E   E + S S+L+          G   S              LRE  Q+L S Q 
Sbjct: 1464 DAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQR 1523

Query: 775  IKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLER 834
             +  L  Q        A +E       ++A++LQ  +  SE+ +R      +   VQ E 
Sbjct: 1524 ERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVD--GRLSGVQAEL 1581

Query: 835  IRQADSLER 843
              Q +S+ R
Sbjct: 1582 ALQEESVRR 1590



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 168/827 (20%), Positives = 311/827 (37%), Gaps = 144/827 (17%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKR----QNAVLQAAQD 69
            L+  + E+E+   E  R  Q+L ++     ++   L     E   R    + A  ++ ++
Sbjct: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323

Query: 70   DLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYE 129
             LG LR +L + +A +E ++    V++   QE   E + + R  + SL+       +  +
Sbjct: 1324 TLG-LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLD 1382

Query: 130  HQFHLRLEQERTQWAQYRESAEREIADLRRRLS------EGQEEENLENEMKKAQEDAEK 183
            H   L L+ E         +A  E A+L  RLS      +G E E    E+++   +A+ 
Sbjct: 1383 HARGLELKLE---------AARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQL 1433

Query: 184  --LRSVVM----------PMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCR 231
              LRS +           P  + +     +   AE   + L +    E          C 
Sbjct: 1434 GGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLE----------CS 1483

Query: 232  TDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQ 291
               +       T  +    D E +R  L E    L   +++ ++L+      N Q  E  
Sbjct: 1484 PGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAE-- 1541

Query: 292  RLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCA 351
                     ME    S   R   +L+K   E +E +R     D + + V+ E+ +     
Sbjct: 1542 ---------MEAERDSATSR-ARQLQKAVAESEEARR---SVDGRLSGVQAELAL----- 1583

Query: 352  LTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSL 411
              QEES  +   E     +T   V +L+  L     +             LR +Q  + +
Sbjct: 1584 --QEESVRRSERERR---ATLDQVATLERSLQATESE-------------LRASQ--EKI 1623

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPL-VGADSVSENFDTASLGSLQMPSGFMLTK 470
                + ++K  G   + K   +  ES    L +   S+      + LG     +     +
Sbjct: 1624 SKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQ 1683

Query: 471  DQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLG 530
            D+  +++    + E  A  L    + +  A         V E+E  L  K          
Sbjct: 1684 DRVDSLQRQVADSEVKAGTLQLTVERLNGALAK------VEESEGALRDKV--------- 1728

Query: 531  RRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSE 590
                      + L     Q + + +  +   L L++A    E   +  QE  D  +Q+  
Sbjct: 1729 ----------RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALS 1778

Query: 591  DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND 650
            ++  Q S+L  + Q     + +L+    +A+  +Q+   VL Q +E  +  L  +QK  D
Sbjct: 1779 EARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD 1838

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVE-EKLK------ 703
              +       SLQ+A   +  +  E  R   L+  +D + +R   D VE EKL+      
Sbjct: 1839 ERRLLQERLGSLQRALAQLEAEKREVERS-ALRLEKDRVALRRTLDKVEREKLRSHEDTV 1897

Query: 704  --------------------AEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISS 743
                                AE     +Q++A+  + E      QLE++  ++++     
Sbjct: 1898 RLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL----E 1953

Query: 744  LKAELERIKVEKGQLESTL----REKSQQLESLQEIKISLEEQLKKE 786
            L+ E+ER++  + Q E TL    R   Q++  L+E   +L+ QL++E
Sbjct: 1954 LQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQE 2000



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 62/276 (22%), Positives = 121/276 (43%), Gaps = 41/276 (14%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKE--EDLKRQNAVL----QA 66
            +L Q  A L     + L  Q+ L    + ++   + L  A++   + ++Q++ L    Q 
Sbjct: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQT 1793

Query: 67   AQDDLGHLRTQLWEAQAEMENIKAIATVSE-------NTKQEAIDEVKRQWREEVASLQA 119
             + ++  L  Q  EA+ +++ ++ +    +       NT Q+  DE +R  +E + SLQ 
Sbjct: 1794 LRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDE-RRLLQERLGSLQR 1852

Query: 120  VMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQE 179
             + +            LE E+ +  +     E++   LRR L      + +E E  ++ E
Sbjct: 1853 ALAQ------------LEAEKREVERSALRLEKDRVALRRTL------DKVEREKLRSHE 1894

Query: 180  DAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVA 239
            D  +L +    +++ +   + +L EA+ +I++LEA  V      LE   S    LE+   
Sbjct: 1895 DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVV-----VLEQSHS-PAQLEVDA- 1947

Query: 240  VLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQ 275
                Q+  LQ++ E+LR    +    LE   + H Q
Sbjct: 1948 --QQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 134/713 (18%), Positives = 280/713 (39%), Gaps = 77/713 (10%)

Query: 174 MKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD 233
           + +AQE    L +V+  +E  +   ++K   A D  ++ + + +  L   +      + +
Sbjct: 5   LARAQEVELTLETVIQTLESSVLC-QEKGLGARDLAQDAQITSLPALIREIVTRNLSQPE 63

Query: 234 LEMYVAVLNTQKSV-LQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQR 292
             + +        + LQE+ + L++EL  V  LL Q R + ++L   +   +++  ++ R
Sbjct: 64  SPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALR 123

Query: 293 LLMRDMQRME---IVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVV 349
           L   +++  E   +V  S +LR+  +L+++      + +  +    ++A + + ++  ++
Sbjct: 124 LEPGELETQEPRGLVRQSVELRR--QLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKIL 181

Query: 350 -----CALTQE---ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKS---DNDMF 398
                C+  ++   E S +L  E++ L  T  S     A + L      S S    N M 
Sbjct: 182 QYKKRCSELEQQLLERSGEL--EQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAML 239

Query: 399 KDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLG 458
           ++ L +A S +    S  ++     +    K   + + +        ++   N  +  L 
Sbjct: 240 REQLDQAGSANQ-ALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLL 298

Query: 459 SLQMPSGFMLTKDQ-----ERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSET 513
             +   GF     +     ER +  +  E   T+  +     G+ +      G RL    
Sbjct: 299 LWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLST------GLRLAESR 352

Query: 514 EWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQ-----VKKLQLMLRQAN 568
               L+K+             + +  E+QL+   ++E +   Q     + K  L  R   
Sbjct: 353 AEAALEKQAL-----------LQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTE 401

Query: 569 DQLEKTMKDKQELEDFIKQSSEDSSHQISALV-LRAQASEILLEELQQGLSQAKRDVQEQ 627
             L     +KQ LE    Q ++D + ++ AL  LR Q    L  E  +GL Q  RD+ + 
Sbjct: 402 LGLAVKRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQA 459

Query: 628 MAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV-------------SLQQAEDFILPDT- 673
           +    +S  Q+S         N SL+G                   S ++       D+ 
Sbjct: 460 VLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSS 519

Query: 674 TEALRELVLKYRE-DIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIE 732
           T AL    L  R+  + ++R   +  ++ L      L++Q+   +  +  LEE LQ   +
Sbjct: 520 TLALIHSALHKRQLQVQDMRGRYEASQDLLGT----LRKQLSDSESERRALEEQLQRLRD 575

Query: 733 NCKEEIASISSLKAELERIKV-------EKGQLESTLREKSQQLESLQEIKISLEEQLKK 785
                + +    + E++R++        EK  L  +L+   QQ E L++ +  L+   ++
Sbjct: 576 KTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEE 635

Query: 786 ETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQA 838
               +  +E+   +      R++ EL+ S +           L  +L  +R+A
Sbjct: 636 LRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREA 688


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 158/848 (18%), Positives = 353/848 (41%), Gaps = 87/848 (10%)

Query: 56   DLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVK-------- 107
            DL++Q   L+  +D+       L++A+   ++++++     NT    ++E K        
Sbjct: 880  DLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISG 939

Query: 108  -RQWREEVASLQAVMKETVRDYEHQFH---------LRLEQERTQWAQYRESAEREIADL 157
             R   EEV  +  +   +++DYE Q           L +  +RT          +E AD+
Sbjct: 940  KRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADV 999

Query: 158  RRR----LSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKEL- 212
              R    L+   +     +EM K+ ED +   + +  +E+E+   +D  +E  +K K L 
Sbjct: 1000 HARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLD 1059

Query: 213  --------EASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCH 264
                    E S+ K     LE  K  + +L+   A  N  K   Q   ++L +++  + +
Sbjct: 1060 QNLQKYQAECSQFKAKLASLEELKR-QAELDGKSAKQNLDKCYGQ--IKELNEKITRLTY 1116

Query: 265  LLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDD 324
             +E E+++   ++  + +  + + + Q+    + +     L  ++L   + +K+K+ E +
Sbjct: 1117 EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKEN----LGWQKLESEKAIKEKEYEIE 1172

Query: 325  EQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSL------ 378
              + L + +  +K + E E+    V     EE S   +  E  ++ T+ ++  +      
Sbjct: 1173 RLRVLLQEEGTRKREYENELA--KVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKED 1230

Query: 379  DAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESD 438
            D+  L    D  S+ + D+ KD + R   +    T    +++      KA  +  + +  
Sbjct: 1231 DSKNLRNQLDRLSRENRDL-KDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQ 1289

Query: 439  FGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASL-------LS 491
               +     + +  +  +     +       +D+ + I+ +  E +E A         LS
Sbjct: 1290 HLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELS 1349

Query: 492  SVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEA 551
             V    +   +S        ETE N+ +  +H    +   + +  S Y  Q+  +  +  
Sbjct: 1350 KVRNNYDEEIISLKNQ---FETEINITKTTIHQLTMQ---KEEDTSGYRAQIDNLTRENR 1403

Query: 552  ETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLE 611
               +++K+L+  L Q  + L +  +D Q+ +      SE S  +    V   Q +++  E
Sbjct: 1404 SLSEEIKRLKNTLTQTTENLRRVEEDIQQQK---ATGSEVSQRKQQLEVELRQVTQMRTE 1460

Query: 612  E---LQQGLSQAKRDVQEQMAVLMQSREQVSEELVR---LQKDNDSLQG-KHSLHVSLQQ 664
            E    +Q L  A + +Q++   + + ++ + +E      L+ +N  LQ  ++ L  +   
Sbjct: 1461 ESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSS 1520

Query: 665  AEDFI--LPDTTEALRELVLKYREDIINVRTAADH--------------VEEKLKAEILF 708
            A + I  L    + L  L + Y E +   RT  D                ++K++ E+  
Sbjct: 1521 ATETINKLKVQEQELTRLRIDY-ERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNR 1579

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQ 768
            LK     + C ++ LEE L+    + KE+   I++L  +LE+  + K + E  LR++   
Sbjct: 1580 LKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDV 1639

Query: 769  LESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 828
            L+     K   +E+L++ ++    + + + +E+   ++     +  ++   D  +     
Sbjct: 1640 LDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNES 1699

Query: 829  QVQLERIR 836
            ++++ER++
Sbjct: 1700 KIEIERLQ 1707



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 176/900 (19%), Positives = 367/900 (40%), Gaps = 120/900 (13%)

Query: 38   EFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIA-TVSE 96
            +F  K A  +EL    E D K     L      +  L  ++     E+E+ K    +V +
Sbjct: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVED 1130

Query: 97   NTKQEAID----EVKRQWREEVASLQAVMKETV---RDYE-HQFHLRLEQERTQWAQYRE 148
               Q+  D    +  RQ  +E    Q +  E     ++YE  +  + L++E T+  +Y  
Sbjct: 1131 RFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY-- 1188

Query: 149  SAEREIADLRRRLSEGQEEENLENEMK---------------KAQEDAEKLRSVVMPMEK 193
              E E+A +R   +E  E  NL N+ +               + ++D++ LR+ +  + +
Sbjct: 1189 --ENELAKVRNHYNE--EMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSR 1244

Query: 194  EIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQ-KSVLQ--- 249
            E   LKD++    D I +    + +   + L+ +K+C +++      L  + K V+Q   
Sbjct: 1245 ENRDLKDEIVRLNDSILQATEQRRRAEENALQ-QKACGSEIMQKKQHLEIELKQVMQQRS 1303

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLK--------HTWQKAND-----QFLESQRLLMR 296
            ED  + ++ L E    ++ + ++  +LK          W+  N+        + + + ++
Sbjct: 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLK 1363

Query: 297  DMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEE 356
            +    EI +T   + Q+   K++D      Q  N  ++++   + EEIK  +   LTQ  
Sbjct: 1364 NQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRS--LSEEIK-RLKNTLTQTT 1420

Query: 357  SSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGS 416
             + +   E+       GS  S              K   ++    + + ++ +S+    S
Sbjct: 1421 ENLRRVEEDIQQQKATGSEVSQ------------RKQQLEVELRQVTQMRTEESVRYKQS 1468

Query: 417  LQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENF---DTASLGSLQMPSGFMLTKDQE 473
            L   A     K K    L +     L+  ++        + A L  +Q       +   E
Sbjct: 1469 LDDAAKTIQDKNKEIERLKQ-----LIDKETNDRKCLEDENARLQRVQYDLQKANSSATE 1523

Query: 474  RAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKE-VHNAGNKLGRR 532
               K    EQE T   +       E         R  +  +   LQK+ V    N+L R 
Sbjct: 1524 TINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRT 1583

Query: 533  C--DMCSN--YEKQLQGIQ-------------IQEAETRDQVKKL-QLMLRQANDQLEKT 574
               D C     E++L+G++              Q+ E    VKK  +  LRQ  D L+  
Sbjct: 1584 ASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGH 1643

Query: 575  MKDKQELEDFIKQSSED----------SSHQISALVLRAQASEILLEELQQGLSQAKRDV 624
            +++KQ  ++ +++ S +              +    LR +  +  +E+  + L+++K ++
Sbjct: 1644 LREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI 1703

Query: 625  QEQMAV---LMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELV 681
            +   ++   L +    + EEL  L+ + D L+   S   S + A    L    +      
Sbjct: 1704 ERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRT 1763

Query: 682  LKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQL--EIENCKEEIA 739
            L+ +  I +++   +++ ++++    F K+ ++A   ++E+  +  Q+  E E+   +I 
Sbjct: 1764 LELQGLINDLQRERENLRQEIEK---FQKQALEASNRIQESKNQCTQVVQERESLLVKIK 1820

Query: 740  SISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFE 799
             +   KA L+R++ E  + +STL  +++  + L+  K  ++  L +     +  E+ +  
Sbjct: 1821 VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI-- 1878

Query: 800  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQL 859
                 +++++E + SE+ +       + LQ +++RI      ER R  L D+     +QL
Sbjct: 1879 -----RKIESEREKSEREKNSLRSEIERLQAEIKRIE-----ERCRRKLEDSTRETQSQL 1928



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 173/836 (20%), Positives = 337/836 (40%), Gaps = 180/836 (21%)

Query: 20   ELEKI----NAEFLRAQQQLEQEFNQKRAKFKELYLAKEED----------LKRQNAVLQ 65
            EL K+    N E    + + E E N  +   KE+ + KE+D          L R+N  L 
Sbjct: 1191 ELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDL- 1249

Query: 66   AAQDDLGHLRTQLWEA-----QAEMENIKAIATVSENTKQE-----AIDEVKRQWREEVA 115
              +D++  L   + +A     +AE   ++  A  SE  +++      + +V +Q  E+ A
Sbjct: 1250 --KDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNA 1307

Query: 116  SLQAVMKE---TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLEN 172
              +  ++E   T++D   +   RL+ E  + A+ R   E E++ +R    E  E  +L+N
Sbjct: 1308 RHKQSLEEAAKTIQDKNKEIE-RLKAEFQEEAKRRWEYENELSKVRNNYDE--EIISLKN 1364

Query: 173  EMK---------------KAQEDAEKLRSVV-------MPMEKEIAALKDKLTEAEDKIK 210
            + +               + +ED    R+ +         + +EI  LK+ LT+  + ++
Sbjct: 1365 QFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLR 1424

Query: 211  ELE---------ASKVKELNHYLEAEKSCRTDLE-----MYVAVLNTQKSVLQE---DAE 253
             +E          S+V +    LE E    T +       Y   L+     +Q+   + E
Sbjct: 1425 RVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIE 1484

Query: 254  KLRKELHEVCH---LLEQERQQHNQLKHTWQKANDQFLES-QRLLMRDMQRMEIVLTSEQ 309
            +L++ + +  +    LE E  +  ++++  QKAN    E+  +L +++ +   + +  E+
Sbjct: 1485 RLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYER 1544

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
            + Q  E   KDQ+    Q   K    +K  VEEE+        T  E S +    EE L+
Sbjct: 1545 VSQ--ERTVKDQDITRFQNSLKELQLQKQKVEEELN---RLKRTASEDSCKRKKLEEELE 1599

Query: 370  STRGSVHSL------------DAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSL 417
              R S+                A ++    +   +   D+    LR  Q T         
Sbjct: 1600 GMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQE------- 1652

Query: 418  QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIK 477
            + + L    +A     L E +   +  A   +E+F  A              +D+ R++ 
Sbjct: 1653 ELRRLSSEVEALRRQLLQEQE--SVKQAHLRNEHFQKA-------------IEDKSRSLN 1697

Query: 478  AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCS 537
                E E   SL  ++T+             L+ E E   L+ E  +       R +  S
Sbjct: 1698 ESKIEIERLQSLTENLTK-----------EHLMLEEELRNLRLEYDDLRR---GRSEADS 1743

Query: 538  NYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQIS 597
            +    +  ++ Q   + ++  +LQ ++   ND   +    +QE+E F KQ+ E S+    
Sbjct: 1744 DKNATILELRSQLQISNNRTLELQGLI---NDLQRERENLRQEIEKFQKQALEASN---- 1796

Query: 598  ALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSL-QGKH 656
                           +Q+  +Q  + VQE+ ++L++ +  + ++  RLQ+  D L + K 
Sbjct: 1797 --------------RIQESKNQCTQVVQERESLLVKIK-VLEQDKARLQRLEDELNRAKS 1841

Query: 657  SLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAE 716
            +L    +      +    E  ++ +   + D+   +T     EE ++        +I++E
Sbjct: 1842 TLEAETR------VKQRLECEKQQI---QNDLNQWKTQYSRKEEAIR--------KIESE 1884

Query: 717  QCLKENLEETLQLEIENCKEEIASISSLKAELERIKVE-KGQLESTLREKSQQLES 771
            +   E  + +L+ EIE           L+AE++RI+   + +LE + RE   QLE+
Sbjct: 1885 REKSEREKNSLRSEIER----------LQAEIKRIEERCRRKLEDSTRETQSQLET 1930



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 48/249 (19%), Positives = 106/249 (42%), Gaps = 16/249 (6%)

Query: 18   VAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQ 77
            +  L+ +     +    LE+E    R ++ +L   + E    +NA +   +  L     +
Sbjct: 1703 IERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNR 1762

Query: 78   LWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
              E Q  + +++      EN +QE I++ ++Q  E    +Q    +  +  + +  L   
Sbjct: 1763 TLELQGLINDLQ---RERENLRQE-IEKFQKQALEASNRIQESKNQCTQVVQERESLLVK 1818

Query: 136  ---LEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
               LEQ++ +  +  +   R  + L    +E + ++ LE E ++ Q D  + ++     E
Sbjct: 1819 IKVLEQDKARLQRLEDELNRAKSTLE---AETRVKQRLECEKQQIQNDLNQWKTQYSRKE 1875

Query: 193  KEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV----AVLNTQKSVL 248
            + I  ++ +  ++E +   L +   +        E+ CR  LE       + L T++S  
Sbjct: 1876 EAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRY 1935

Query: 249  QEDAEKLRK 257
            Q + +KLR+
Sbjct: 1936 QREIDKLRQ 1944



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 47/192 (24%), Positives = 79/192 (41%), Gaps = 25/192 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L+Q  A L+++  E  RA+  LE E   K+               R     Q  Q+DL  
Sbjct: 1822 LEQDKARLQRLEDELNRAKSTLEAETRVKQ---------------RLECEKQQIQNDLNQ 1866

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFH 133
             +TQ    +  +  I++    SE  K     E++R  + E+  ++   +  + D   +  
Sbjct: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERL-QAEIKRIEERCRRKLEDSTRETQ 1925

Query: 134  LRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENE--MKKAQEDAEKLRSVVMPM 191
             +LE ER+++       +REI  LR+R      E   E E  +  ++   + LR  V  M
Sbjct: 1926 SQLETERSRY-------QREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAM 1978

Query: 192  EKEIAALKDKLT 203
            +     L DK T
Sbjct: 1979 QLYECQLIDKTT 1990



 Score = 31.2 bits (69), Expect = 4.3
 Identities = 31/129 (24%), Positives = 56/129 (43%), Gaps = 28/129 (21%)

Query: 146 YRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLR---SVVMPMEKEIAALKD-- 200
           YR   ++  ADLR + +  Q EE  EN +K + E  + LR   +++    +EI  + D  
Sbjct: 231 YRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCE 290

Query: 201 ----------------------KLTEAEDKIKELEASKVKELNHYLEAEKSCRTD-LEMY 237
                                  +  ++ ++KE E +K+K+ +  L   +   +D +E Y
Sbjct: 291 EEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAY 350

Query: 238 VAVLNTQKS 246
           +  L TQ S
Sbjct: 351 MDTLQTQWS 359


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.125    0.323 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,248,916
Number of Sequences: 37866
Number of extensions: 1277746
Number of successful extensions: 22448
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 442
Number of HSP's successfully gapped in prelim test: 1269
Number of HSP's that attempted gapping in prelim test: 7796
Number of HSP's gapped (non-prelim): 8235
length of query: 862
length of database: 18,247,518
effective HSP length: 111
effective length of query: 751
effective length of database: 14,044,392
effective search space: 10547338392
effective search space used: 10547338392
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.