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Search of human proteins with 31317309
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31317309 phosphatidylinositol-4-phosphate 5-kinase, type I,
gamma [Homo sapiens]
(668 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31317309 phosphatidylinositol-4-phosphate 5-kinase, type I, g... 1328 0.0
gi|208431778 phosphatidylinositol-4-phosphate 5-kinase, type I, ... 681 0.0
gi|4505815 phosphatidylinositol-4-phosphate 5-kinase, type I, al... 677 0.0
gi|208431776 phosphatidylinositol-4-phosphate 5-kinase, type I, ... 657 0.0
gi|4505817 phosphatidylinositol-4-phosphate 5-kinase, type I, be... 652 0.0
gi|208431774 phosphatidylinositol-4-phosphate 5-kinase, type I, ... 620 e-177
gi|226371739 phosphatidylinositol-5-phosphate 4-kinase, type II,... 167 3e-41
gi|226371737 phosphatidylinositol-5-phosphate 4-kinase, type II,... 167 3e-41
gi|4505819 phosphatidylinositol-5-phosphate 4-kinase, type II, b... 167 3e-41
gi|226371741 phosphatidylinositol-5-phosphate 4-kinase, type II,... 160 3e-39
gi|6857820 phosphatidylinositol-5-phosphate 4-kinase, type II, a... 159 1e-38
gi|226371743 phosphatidylinositol-5-phosphate 4-kinase, type II,... 139 6e-33
gi|206725454 phosphatidylinositol-4-phosphate 5-kinase-like 1 is... 100 3e-21
gi|121583483 phosphatidylinositol-3-phosphate 5-kinase type III ... 57 7e-08
gi|27735085 phosphatidylinositol-4-phosphate 5-kinase-like 1 iso... 54 4e-07
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 41 0.003
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 41 0.003
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 41 0.003
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 41 0.003
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 41 0.003
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 41 0.004
gi|49472835 bridging integrator 2 [Homo sapiens] 40 0.007
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 40 0.009
gi|126090892 aggrecan isoform 2 precursor [Homo sapiens] 39 0.015
gi|217330641 IWS1 homolog [Homo sapiens] 39 0.015
gi|126090883 aggrecan isoform 1 precursor [Homo sapiens] 39 0.020
gi|58530876 melanoma antigen family C, 1 [Homo sapiens] 38 0.034
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 38 0.034
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens] 38 0.034
gi|239756116 PREDICTED: hypothetical protein [Homo sapiens] 37 0.045
>gi|31317309 phosphatidylinositol-4-phosphate 5-kinase, type I,
gamma [Homo sapiens]
Length = 668
Score = 1328 bits (3438), Expect = 0.0
Identities = 668/668 (100%), Positives = 668/668 (100%)
Query: 1 MELEVPDEAESAEAGAVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGH 60
MELEVPDEAESAEAGAVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGH
Sbjct: 1 MELEVPDEAESAEAGAVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGH 60
Query: 61 RGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGS 120
RGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGS
Sbjct: 61 RGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGS 120
Query: 121 NLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVT 180
NLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVT
Sbjct: 121 NLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVT 180
Query: 181 SDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNN 240
SDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNN
Sbjct: 181 SDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNN 240
Query: 241 ILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVK 300
ILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVK
Sbjct: 241 ILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVK 300
Query: 301 TLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMES 360
TLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMES
Sbjct: 301 TLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMES 360
Query: 361 IQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDG 420
IQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDG
Sbjct: 361 IQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDG 420
Query: 421 DTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQI 480
DTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQI
Sbjct: 421 DTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQI 480
Query: 481 PSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSP 540
PSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSP
Sbjct: 481 PSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSP 540
Query: 541 SETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEAS 600
SETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEAS
Sbjct: 541 SETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEAS 600
Query: 601 PAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPP 660
PAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPP
Sbjct: 601 PAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPP 660
Query: 661 ASDGESDT 668
ASDGESDT
Sbjct: 661 ASDGESDT 668
>gi|208431778 phosphatidylinositol-4-phosphate 5-kinase, type I,
alpha isoform 1 [Homo sapiens]
Length = 562
Score = 681 bits (1757), Expect = 0.0
Identities = 353/510 (69%), Positives = 404/510 (79%), Gaps = 5/510 (0%)
Query: 16 AVPSEAAWAAESGAAAGLAQK--KAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKK 73
AVPS +A SG +A + +A +S+ KK+GHR VD+SGETTYKK
Sbjct: 20 AVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMPIKKIGHRSVDSSGETTYKK 79
Query: 74 TTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRF 133
TTSS LKGAIQLGI +TVG LS+KPERDVLMQDFYVVESIFFPSEGSNLTPAHH+ DFRF
Sbjct: 80 TTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRF 139
Query: 134 KTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHK 193
KTYAPVAFRYFRELFGIRPDDYLYSLC+EPLIEL + GASGSLFYV+SDDEFIIKTV HK
Sbjct: 140 KTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHK 199
Query: 194 EAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFD 253
EAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQ+GGKNIR+VVMNN+LPR VKMH+K+D
Sbjct: 200 EAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYD 259
Query: 254 LKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFK 313
LKGSTYKRRAS+KE+EK PT+KDLDF+QD+P+GL LDAD ++AL KTLQRDCLVL+SFK
Sbjct: 260 LKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFK 319
Query: 314 IMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIES 373
IMDYSLL+ +HNID +RE + Q + D +RP QKALYSTAMESIQG A RG +E+
Sbjct: 320 IMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMET 379
Query: 374 DDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAE 433
DD MGGIPA N +GERLLL+IGIIDILQSYRF+KKLEH+WKALVHDGDTVSVHRP FYAE
Sbjct: 380 DDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHRPGFYAE 439
Query: 434 RFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRG 493
RF +FM NTVF+K LK SPSKK R G+ + + G + + PS E + +
Sbjct: 440 RFQRFMCNTVFKK-IPLKPSPSKKFRSGSSFS-RRAGSSGNSCITYQPSVSGEHKAQVTT 497
Query: 494 ARSYPTLEDEGRPDLLPCTPPSFEEATTAS 523
GRPD+LP TPP EE + S
Sbjct: 498 KAEVEPGVHLGRPDVLPQTPP-LEEISEGS 526
>gi|4505815 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
isoform 2 [Homo sapiens]
Length = 549
Score = 677 bits (1748), Expect = 0.0
Identities = 343/468 (73%), Positives = 388/468 (82%), Gaps = 3/468 (0%)
Query: 56 KKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFF 115
KK+GHR VD+SGETTYKKTTSS LKGAIQLGI +TVG LS+KPERDVLMQDFYVVESIFF
Sbjct: 49 KKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFF 108
Query: 116 PSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGS 175
PSEGSNLTPAHH+ DFRFKTYAPVAFRYFRELFGIRPDDYLYSLC+EPLIEL + GASGS
Sbjct: 109 PSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGS 168
Query: 176 LFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRV 235
LFYV+SDDEFIIKTV HKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQ+GGKNIR+
Sbjct: 169 LFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRI 228
Query: 236 VVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTF 295
VVMNN+LPR VKMH+K+DLKGSTYKRRAS+KE+EK PT+KDLDF+QD+P+GL LDAD +
Sbjct: 229 VVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMY 288
Query: 296 SALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYS 355
+AL KTLQRDCLVL+SFKIMDYSLL+ +HNID +RE + Q + D +RP QKALYS
Sbjct: 289 NALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYS 348
Query: 356 TAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKA 415
TAMESIQG A RG +E+DD MGGIPA N +GERLLL+IGIIDILQSYRF+KKLEH+WKA
Sbjct: 349 TAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKA 408
Query: 416 LVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAF 475
LVHDGDTVSVHRP FYAERF +FM NTVF+K LK SPSKK R G+ + + G +
Sbjct: 409 LVHDGDTVSVHRPGFYAERFQRFMCNTVFKK-IPLKPSPSKKFRSGSSFS-RRAGSSGNS 466
Query: 476 SASQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTAS 523
+ PS E + + GRPD+LP TPP EE + S
Sbjct: 467 CITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPP-LEEISEGS 513
>gi|208431776 phosphatidylinositol-4-phosphate 5-kinase, type I,
alpha isoform 4 [Homo sapiens]
Length = 500
Score = 657 bits (1694), Expect = 0.0
Identities = 318/391 (81%), Positives = 354/391 (90%)
Query: 56 KKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFF 115
KK+GHR VD+SGETTYKKTTSS LKGAIQLGI +TVG LS+KPERDVLMQDFYVVESIFF
Sbjct: 49 KKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFF 108
Query: 116 PSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGS 175
PSEGSNLTPAHH+ DFRFKTYAPVAFRYFRELFGIRPDDYLYSLC+EPLIEL + GASGS
Sbjct: 109 PSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGS 168
Query: 176 LFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRV 235
LFYV+SDDEFIIKTV HKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQ+GGKNIR+
Sbjct: 169 LFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRI 228
Query: 236 VVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTF 295
VVMNN+LPR VKMH+K+DLKGSTYKRRAS+KE+EK PT+KDLDF+QD+P+GL LDAD +
Sbjct: 229 VVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMY 288
Query: 296 SALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYS 355
+AL KTLQRDCLVL+SFKIMDYSLL+ +HNID +RE + Q + D +RP QKALYS
Sbjct: 289 NALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYS 348
Query: 356 TAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKA 415
TAMESIQG A RG +E+DD MGGIPA N +GERLLL+IGIIDILQSYRF+KKLEH+WKA
Sbjct: 349 TAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKA 408
Query: 416 LVHDGDTVSVHRPSFYAERFFKFMSNTVFRK 446
LVHDGDTVSVHRP FYAERF +FM NTVF+K
Sbjct: 409 LVHDGDTVSVHRPGFYAERFQRFMCNTVFKK 439
>gi|4505817 phosphatidylinositol-4-phosphate 5-kinase, type I, beta
isoform 2 [Homo sapiens]
Length = 540
Score = 652 bits (1681), Expect = 0.0
Identities = 332/482 (68%), Positives = 394/482 (81%), Gaps = 13/482 (2%)
Query: 68 ETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHH 127
E TYKKT SS +KGAIQLGIGYTVG+L+SKPERDVLMQDFYVVES+F PSEGSNLTPAHH
Sbjct: 18 EKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHH 77
Query: 128 FQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFII 187
+ DFRFKTYAP+AFRYFRELFGI+PDDYLYS+C+EPLIELSNPGASGSLF+VTSDDEFII
Sbjct: 78 YPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFVTSDDEFII 137
Query: 188 KTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVK 247
KTV HKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYC+QSGG NIR+VVMNN+LPR ++
Sbjct: 138 KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRSMR 197
Query: 248 MHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCL 307
MH +DLKGSTYKRRAS+KE+EKS PT+KDLDF+QDM EGL D +T++AL+KTLQRDC
Sbjct: 198 MHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCR 257
Query: 308 VLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAAR 367
VLESFKIMDYSLLLG+H +D +E++ + Q+ D KR QK LYSTAMESIQG
Sbjct: 258 VLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQKVLYSTAMESIQGPGKS 317
Query: 368 GEAI--ESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSV 425
G+ I E+ DTMGGIPA + RGE+LLL +GIIDILQSYR +KKLEH+WKALV+DGDTVSV
Sbjct: 318 GDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSV 377
Query: 426 HRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSERE 485
HRPSFYA+RF KFM++ VF+K +LK+SPSKK R ++ A+K S SQ ++
Sbjct: 378 HRPSFYADRFLKFMNSRVFKKIQALKASPSKK-RCNSIAALKATSQEIVSSISQ--EWKD 434
Query: 486 EAQYDLRGARSYPTLEDEG-----RPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSP 540
E + L +S+ +L++E RPDL+P TP FE AS+ATT+SS+SL + E P
Sbjct: 435 EKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFE---AASLATTISSSSLYVNEHYP 491
Query: 541 SE 542
+
Sbjct: 492 HD 493
>gi|208431774 phosphatidylinositol-4-phosphate 5-kinase, type I,
alpha isoform 3 [Homo sapiens]
Length = 522
Score = 620 bits (1598), Expect = e-177
Identities = 331/508 (65%), Positives = 380/508 (74%), Gaps = 41/508 (8%)
Query: 16 AVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTT 75
AVPS S AA+G+ K+ +EV + P KK+GHR VD+SGETTYKKTT
Sbjct: 20 AVPS----CTLSSAASGI--KRPMASEVPYASGMPI----KKIGHRSVDSSGETTYKKTT 69
Query: 76 SSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKT 135
SS LKGAIQLGI +TVG LS+KPERDVLMQDFYVVESIFFPSEGSNLTPAHH+ DFRFKT
Sbjct: 70 SSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKT 129
Query: 136 YAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEA 195
YAPVAFRYFRELFGIRPDDYLYSLC+EPLIEL + GASGSLFYV+SDDEFIIKTV HKEA
Sbjct: 130 YAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEA 189
Query: 196 EFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLK 255
EFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQ+GGKNIR+VVMNN+LPR VKMH+K+DLK
Sbjct: 190 EFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLK 249
Query: 256 GSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIM 315
GSTYKRRAS+KE+EK PT+KDLDF+QD+P+GL LDAD ++AL KTLQRDCLVL+SFKIM
Sbjct: 250 GSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIM 309
Query: 316 DYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDD 375
DYSLL+ +HNID +RE + Q + D +RP QKALYSTAMESIQG A RG +E+DD
Sbjct: 310 DYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDD 369
Query: 376 TMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERF 435
+F+KKLEH+WKALVHDGDTVSVHRP FYAERF
Sbjct: 370 ----------------------------QFVKKLEHSWKALVHDGDTVSVHRPGFYAERF 401
Query: 436 FKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGAR 495
+FM NTVF+K LK SPSKK R G+ + + G + + PS E + +
Sbjct: 402 QRFMCNTVFKK-IPLKPSPSKKFRSGSSFS-RRAGSSGNSCITYQPSVSGEHKAQVTTKA 459
Query: 496 SYPTLEDEGRPDLLPCTPPSFEEATTAS 523
GRPD+LP TPP EE + S
Sbjct: 460 EVEPGVHLGRPDVLPQTPP-LEEISEGS 486
>gi|226371739 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform a [Homo sapiens]
Length = 421
Score = 167 bits (423), Expect = 3e-41
Identities = 135/428 (31%), Positives = 202/428 (47%), Gaps = 29/428 (6%)
Query: 33 LAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVG 92
+A P V + TA PGPG G + + + L G G+ +++
Sbjct: 1 MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSIN 60
Query: 93 HLSSKPERDVLMQDFYVVESIFFPSEG----SNLTPAHHFQDFRFKTYAPVAFRYFRELF 148
LS P +L+ D + S + NL P+H F+FK Y P FR R+ F
Sbjct: 61 ELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENL-PSH----FKFKEYCPQVFRNLRDRF 115
Query: 149 GIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMN 208
GI DYL SL P E + G+ G F ++ D +IK V ++ + L Y+
Sbjct: 116 GIDDQDYLVSLTRNPPSE--SEGSDGR-FLISYDRTLVIKEVSSEDIADMHSNLSNYHQY 172
Query: 209 LNQ-NPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKE 267
+ + + TLLP+F G+Y V ++ ++VM N+ + +H K+DLKGS R AS KE
Sbjct: 173 IVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKE 232
Query: 268 KEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNI- 326
K K PT KD+DF+ + + + + + ++ L+RD L KIMDYSLLLG+H+I
Sbjct: 233 KVKELPTLKDMDFL-NKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDII 291
Query: 327 --DQHERERQAQGAQSTSD-EKRPVGQKAL---YSTAMESIQG------GAARGEAIESD 374
+ E E + +S D + G AL Y T+ E I G GE ES
Sbjct: 292 RGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGE-FESF 350
Query: 375 DTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD-GDTVSVHRPSFYAE 433
+ I + G ++ + +G+IDIL Y KK H K + H G +S P YA+
Sbjct: 351 IDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAK 410
Query: 434 RFFKFMSN 441
RF F++N
Sbjct: 411 RFLDFITN 418
>gi|226371737 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform a [Homo sapiens]
Length = 421
Score = 167 bits (423), Expect = 3e-41
Identities = 135/428 (31%), Positives = 202/428 (47%), Gaps = 29/428 (6%)
Query: 33 LAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVG 92
+A P V + TA PGPG G + + + L G G+ +++
Sbjct: 1 MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSIN 60
Query: 93 HLSSKPERDVLMQDFYVVESIFFPSEG----SNLTPAHHFQDFRFKTYAPVAFRYFRELF 148
LS P +L+ D + S + NL P+H F+FK Y P FR R+ F
Sbjct: 61 ELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENL-PSH----FKFKEYCPQVFRNLRDRF 115
Query: 149 GIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMN 208
GI DYL SL P E + G+ G F ++ D +IK V ++ + L Y+
Sbjct: 116 GIDDQDYLVSLTRNPPSE--SEGSDGR-FLISYDRTLVIKEVSSEDIADMHSNLSNYHQY 172
Query: 209 LNQ-NPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKE 267
+ + + TLLP+F G+Y V ++ ++VM N+ + +H K+DLKGS R AS KE
Sbjct: 173 IVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKE 232
Query: 268 KEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNI- 326
K K PT KD+DF+ + + + + + ++ L+RD L KIMDYSLLLG+H+I
Sbjct: 233 KVKELPTLKDMDFL-NKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDII 291
Query: 327 --DQHERERQAQGAQSTSD-EKRPVGQKAL---YSTAMESIQG------GAARGEAIESD 374
+ E E + +S D + G AL Y T+ E I G GE ES
Sbjct: 292 RGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGE-FESF 350
Query: 375 DTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD-GDTVSVHRPSFYAE 433
+ I + G ++ + +G+IDIL Y KK H K + H G +S P YA+
Sbjct: 351 IDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAK 410
Query: 434 RFFKFMSN 441
RF F++N
Sbjct: 411 RFLDFITN 418
>gi|4505819 phosphatidylinositol-5-phosphate 4-kinase, type II, beta
[Homo sapiens]
Length = 416
Score = 167 bits (423), Expect = 3e-41
Identities = 124/384 (32%), Positives = 187/384 (48%), Gaps = 27/384 (7%)
Query: 76 SSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYV------VESIFFPSEGSNLTPAHHFQ 129
S + + G+ +T+ LS+ P +LM D + V++ F E P+
Sbjct: 39 SEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKEN---LPSR--- 92
Query: 130 DFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKT 189
F+FK Y P+ FR RE FGI DY S+ I + G G+ F T D F+IKT
Sbjct: 93 -FKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKT 151
Query: 190 VMHKEAEFLQKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKM 248
V ++ + +L Y+ + + + TLLP+F G+Y + G +VV N+ + +
Sbjct: 152 VSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTV 211
Query: 249 HLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLV 308
H K+DLKGST R AS KEK K PT+KD DF+ + + L + ++ ++ L+RD
Sbjct: 212 HRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNE-GQKLHVGEESKKNFLEKLKRDVEF 270
Query: 309 LESFKIMDYSLLLGVHNIDQHERERQ--AQGAQSTSDEKRPVGQKAL--YSTAME----- 359
L KIMDYSLL+G+H++D+ E+E + A+ E VG L Y T +
Sbjct: 271 LAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNL 330
Query: 360 -SIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVH 418
S GE S D + + ++ + + IIDIL Y KK H K + H
Sbjct: 331 LSFPRFFGPGEFDPSVDVY-AMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKH 389
Query: 419 D-GDTVSVHRPSFYAERFFKFMSN 441
G +S P Y++RF +FMSN
Sbjct: 390 GAGAEISTVNPEQYSKRFNEFMSN 413
>gi|226371741 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform b [Homo sapiens]
Length = 403
Score = 160 bits (406), Expect = 3e-39
Identities = 129/424 (30%), Positives = 194/424 (45%), Gaps = 39/424 (9%)
Query: 33 LAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVG 92
+A P V + TA PGPG G + + + L G G+ +++
Sbjct: 1 MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSIN 60
Query: 93 HLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRP 152
LS P +L+ D + S + K Y P FR R+ FGI
Sbjct: 61 ELSQVPPPVMLLPDDFKASS-------------------KIKEYCPQVFRNLRDRFGIDD 101
Query: 153 DDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQ- 211
DYL SL P E + G+ G F ++ D +IK V ++ + L Y+ + +
Sbjct: 102 QDYLVSLTRNPPSE--SEGSDGR-FLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKC 158
Query: 212 NPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKS 271
+ TLLP+F G+Y V ++ ++VM N+ + +H K+DLKGS R AS KEK K
Sbjct: 159 HGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKE 218
Query: 272 FPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNI---DQ 328
PT KD+DF+ + + + + + ++ L+RD L KIMDYSLLLG+H+I +
Sbjct: 219 LPTLKDMDFL-NKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSE 277
Query: 329 HERERQAQGAQSTSD-EKRPVGQKAL---YSTAMESIQG------GAARGEAIESDDTMG 378
E E + +S D + G AL Y T+ E I G GE ES +
Sbjct: 278 PEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGE-FESFIDVY 336
Query: 379 GIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD-GDTVSVHRPSFYAERFFK 437
I + G ++ + +G+IDIL Y KK H K + H G +S P YA+RF
Sbjct: 337 AIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLD 396
Query: 438 FMSN 441
F++N
Sbjct: 397 FITN 400
>gi|6857820 phosphatidylinositol-5-phosphate 4-kinase, type II,
alpha [Homo sapiens]
Length = 406
Score = 159 bits (401), Expect = 1e-38
Identities = 115/379 (30%), Positives = 183/379 (48%), Gaps = 22/379 (5%)
Query: 76 SSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYV------VESIFFPSEGSNLTPAHHFQ 129
S L + G+ +++ LS +LM D + V++ F E P+H
Sbjct: 34 SDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENM---PSH--- 87
Query: 130 DFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKT 189
F+FK Y P+ FR RE FGI D+ SL + + SG+ F+ + D +IIKT
Sbjct: 88 -FKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKT 146
Query: 190 VMHKEAEFLQKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKM 248
+ ++ + +L Y+ + + + TLLP+F G+Y + G I V+V N+ + +
Sbjct: 147 ITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSV 206
Query: 249 HLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLV 308
+ K+DLKGST R AS KEK K PT KD DF+ + + + +D + ++ L++D
Sbjct: 207 YRKYDLKGSTVAREASDKEKAKELPTLKDNDFINE-GQKIYIDDNNKKVFLEKLKKDVEF 265
Query: 309 LESFKIMDYSLLLGVHNIDQHERE----RQAQG-AQSTSDEKRPVGQKALYSTAMESIQG 363
L K+MDYSLL+G+H++++ E+E + G + SD PVG +
Sbjct: 266 LAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSP 325
Query: 364 GAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD-GDT 422
A GE + D GI + + + IIDIL Y KK H K + H G
Sbjct: 326 PLAPGEFDPNIDVY-GIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAE 384
Query: 423 VSVHRPSFYAERFFKFMSN 441
+S P Y++RF F+ +
Sbjct: 385 ISTVNPEQYSKRFLDFIGH 403
>gi|226371743 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform c [Homo sapiens]
Length = 373
Score = 139 bits (351), Expect = 6e-33
Identities = 125/427 (29%), Positives = 182/427 (42%), Gaps = 75/427 (17%)
Query: 33 LAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVG 92
+A P V + TA PGPG G + + + L G G+ +++
Sbjct: 1 MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSIN 60
Query: 93 HLSSKPERDVLMQDFYVVESIFFPSEG----SNLTPAHHFQDFRFKTYAPVAFRYFRELF 148
LS P +L+ D + S + NL P+H F+FK Y P FR R+ F
Sbjct: 61 ELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENL-PSH----FKFKEYCPQVFRNLRDRF 115
Query: 149 GIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMN 208
GI DYLY I+K
Sbjct: 116 GIDDQDYLY----------------------------IVKC------------------- 128
Query: 209 LNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEK 268
+ TLLP+F G+Y V ++ ++VM N+ + +H K+DLKGS R AS KEK
Sbjct: 129 ---HGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEK 185
Query: 269 EKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNI-- 326
K PT KD+DF+ + + + + + ++ L+RD L KIMDYSLLLG+H+I
Sbjct: 186 VKELPTLKDMDFL-NKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIR 244
Query: 327 -DQHERERQAQGAQSTSD-EKRPVGQKAL---YSTAMESIQG------GAARGEAIESDD 375
+ E E + +S D + G AL Y T+ E I G GE ES
Sbjct: 245 GSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGE-FESFI 303
Query: 376 TMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD-GDTVSVHRPSFYAER 434
+ I + G ++ + +G+IDIL Y KK H K + H G +S P YA+R
Sbjct: 304 DVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKR 363
Query: 435 FFKFMSN 441
F F++N
Sbjct: 364 FLDFITN 370
>gi|206725454 phosphatidylinositol-4-phosphate 5-kinase-like 1
isoform 1 [Homo sapiens]
Length = 394
Score = 100 bits (250), Expect = 3e-21
Identities = 85/327 (25%), Positives = 149/327 (45%), Gaps = 34/327 (10%)
Query: 122 LTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLC-NEPLIELSNPGASGSLFYVT 180
LT H + F T A AF + R G+ +DY +L P ++ + S + F+++
Sbjct: 88 LTQVH--EGFELGTLAGPAFAWLRRSLGLAEEDYQAALGPGGPYLQFLSTSKSKASFFLS 145
Query: 181 SDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQ-SGGKNIRVVVMN 239
D F +KT +E + L LP Y +L ++P +LL + G++ ++ GK +VM
Sbjct: 146 HDQRFFLKTQGRREVQALLAHLPRYVQHLQRHPHSLLARLLGVHSLRVDRGKKTYFIVMQ 205
Query: 240 NILPRVVKMHLKFDLKGSTYKRRASKK-EKEKSFPTYKDLDFMQDMPEGLLLD-ADTFSA 297
++ ++ ++D+KG R E KDL+F +G ++ S
Sbjct: 206 SVFYPAGRISERYDIKGCEVSRWVDPAPEGSPLVLVLKDLNF-----QGKTINLGPQRSW 260
Query: 298 LVKTLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTA 357
++ ++ D L ++DYSLL+ + HE DE+ P G ++ TA
Sbjct: 261 FLRQMELDTTFLRELNVLDYSLLIAFQRL--HE------------DERGP-GSSLIFRTA 305
Query: 358 MESIQGGAARGEAIESD-----DTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHT 412
S+QG + E+ + D + ++G +R L G++D+ Y K+LEH
Sbjct: 306 -RSVQGAQSPEESRAQNRRLLPDAPNALHILDGPEQRYFL--GVVDLATVYGLRKRLEHL 362
Query: 413 WKALVHDGDTVSVHRPSFYAERFFKFM 439
WK L + G T S P+ YA R +++
Sbjct: 363 WKTLRYPGRTFSTVSPARYARRLCQWV 389
>gi|121583483 phosphatidylinositol-3-phosphate 5-kinase type III
isoform 2 [Homo sapiens]
Length = 2098
Score = 56.6 bits (135), Expect = 7e-08
Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 19/207 (9%)
Query: 131 FRFKTYAPVAFRYFRE-LFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKT 189
F + Y F RE + +D++ SL + + + G SG+ FY T DD FI+K
Sbjct: 1820 FYCRLYYAGEFHKMREVILDSSEEDFIRSLSHSSPWQ-ARGGKSGAAFYATEDDRFILKQ 1878
Query: 190 VMHKEAEFLQKLLPGYYMNL----NQNPRTLLPKFYGLYCV------QSGGKNIRVVVMN 239
+ E + P Y+ + Q T L K G+Y + + K + ++VM
Sbjct: 1879 MPRLEVQSFLDFAPHYFNYITNAVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVME 1938
Query: 240 NILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTY----KDLDFMQDMPEGLLLDADTF 295
N+ KM FDLKGS R ++S L ++D P L + + +
Sbjct: 1939 NLF-YGRKMAQVFDLKGSLRNRNVKTDTGKESCDVVLLDENLLKMVRDNP--LYIRSHSK 1995
Query: 296 SALVKTLQRDCLVLESFKIMDYSLLLG 322
+ L ++ D L S I+DYSLL+G
Sbjct: 1996 AVLRTSIHSDSHFLSSHLIIDYSLLVG 2022
>gi|27735085 phosphatidylinositol-4-phosphate 5-kinase-like 1
isoform 2 [Homo sapiens]
Length = 191
Score = 54.3 bits (129), Expect = 4e-07
Identities = 51/196 (26%), Positives = 86/196 (43%), Gaps = 30/196 (15%)
Query: 251 KFDLKGSTYKRRASKK-EKEKSFPTYKDLDFMQDMPEGLLLD-ADTFSALVKTLQRDCLV 308
++D+KG R E KDL+F +G ++ S ++ ++ D
Sbjct: 14 RYDIKGCEVSRWVDPAPEGSPLVLVLKDLNF-----QGKTINLGPQRSWFLRQMELDTTF 68
Query: 309 LESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARG 368
L ++DYSLL+ + HE DE+ P G ++ TA S+QG +
Sbjct: 69 LRELNVLDYSLLIAFQRL--HE------------DERGP-GSSLIFRTA-RSVQGAQSPE 112
Query: 369 EAIESD-----DTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTV 423
E+ + D + ++G +R L G++D+ Y K+LEH WK L + G T
Sbjct: 113 ESRAQNRRLLPDAPNALHILDGPEQRYFL--GVVDLATVYGLRKRLEHLWKTLRYPGRTF 170
Query: 424 SVHRPSFYAERFFKFM 439
S P+ YA R +++
Sbjct: 171 STVSPARYARRLCQWV 186
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 41.2 bits (95), Expect = 0.003
Identities = 46/221 (20%), Positives = 78/221 (35%), Gaps = 8/221 (3%)
Query: 445 RKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEG 504
+++ S P + + +LA P + A ++ + + G+ + +E
Sbjct: 744 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 803
Query: 505 RPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQE 564
L P A++A S P +T + SG +
Sbjct: 804 AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESD 863
Query: 565 ---EPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEG 621
E PA Q+ ++P + V P AG A+PA A AA A +
Sbjct: 864 SDGEAPAAVTSAQV---IKPP--LIFVDPNRSPAGPAATPAQAQAASTPRKARASESTAR 918
Query: 622 APASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPAS 662
+ +S++ DE+ PAT P + V P + AP AS
Sbjct: 919 SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKAS 959
Score = 36.2 bits (82), Expect = 0.10
Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 12/122 (9%)
Query: 518 EATTASIATTLSSTSLSIPERS-PSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQIT 576
EA TA L+ST+ S+ PS E+ + T+ +G+ G P + + +
Sbjct: 95 EAETAKATPRLASTNSSVLGADLPSSMKEKAK--AETEKAGKTGNSMPHPATGKTVANLL 152
Query: 577 V------QVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
EP+ + +V EE+ V A GA+A + +A QA D S +SDE
Sbjct: 153 SGKSPRKSAEPSANTTLVSETEEEGSVPA--FGAAAKPGMVSAGQA-DSSSEDTSSSSDE 209
Query: 631 ED 632
D
Sbjct: 210 TD 211
Score = 35.0 bits (79), Expect = 0.22
Identities = 49/207 (23%), Positives = 85/207 (41%), Gaps = 29/207 (14%)
Query: 448 SSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSERE--EAQYDLRGARSYPTLEDEGR 505
SS + S S++ L VKP G T A+ P++ + ++ P+ G+
Sbjct: 793 SSEEESDSEE-EAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 851
Query: 506 PDLLPCTPPSFEEATTASIATTLSSTSLSI--------PERSPS---------ETSEQPR 548
D + S EE+ + A +++ I P RSP+ + + PR
Sbjct: 852 QD---DSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 908
Query: 549 YRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGV--EASPAGASA 606
R ++S+ + + E +ED+ T + P +V + +AS AGAS+
Sbjct: 909 KARASESTARSSSSESE---DEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASS 965
Query: 607 AVEVETASQASDEEGAPASQASDEEDA 633
+ E S +EG PA+Q S + A
Sbjct: 966 SKESSRISDGKKQEG-PATQVSKKNPA 991
Score = 34.7 bits (78), Expect = 0.29
Identities = 43/212 (20%), Positives = 79/212 (37%), Gaps = 17/212 (8%)
Query: 452 SSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL-P 510
++P+ G+ GA+ + G S S E +++ + A++ + G+ +
Sbjct: 238 ATPAPPGKAGAVASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQAKASGKTSQVGA 296
Query: 511 CTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEE 570
+ P+ E + T ++ + + E +QSS ++ +EE PA+
Sbjct: 297 ASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED------SQSSSEESDSEEEAPAQA 350
Query: 571 DLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
QV A + P++ A G +AA +V+ Q D + SD
Sbjct: 351 KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA-QVQVGKQEEDSRSSSEESDSDR 409
Query: 631 EDAPATDIYFPTDERSWVYSPLHYSAQAPPAS 662
E A + + PL S Q PAS
Sbjct: 410 EALAAMN--------AAQVKPLGKSPQVKPAS 433
Score = 33.9 bits (76), Expect = 0.50
Identities = 33/152 (21%), Positives = 50/152 (32%), Gaps = 26/152 (17%)
Query: 513 PPSFEEATTASIATTLSSTSLSIPERSPSETS---------EQPRYRRRTQSSGQDGRPQ 563
P + A S+ L + S P + P + + E+P + D
Sbjct: 484 PTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADS 543
Query: 564 EEPPAEEDLQQ----ITVQVEPACS-------------VEIVVPKEEDAGVEASPAGASA 606
EE PA Q + + AC V + AG SPAG+S
Sbjct: 544 EEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP 603
Query: 607 AVEVETASQASDEEGAPASQASDEEDAPATDI 638
AV T A D + S + +E+ A +
Sbjct: 604 AVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 635
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 41.2 bits (95), Expect = 0.003
Identities = 46/221 (20%), Positives = 78/221 (35%), Gaps = 8/221 (3%)
Query: 445 RKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEG 504
+++ S P + + +LA P + A ++ + + G+ + +E
Sbjct: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
Query: 505 RPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQE 564
L P A++A S P +T + SG +
Sbjct: 881 AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESD 940
Query: 565 ---EPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEG 621
E PA Q+ ++P + V P AG A+PA A AA A +
Sbjct: 941 SDGEAPAAVTSAQV---IKPP--LIFVDPNRSPAGPAATPAQAQAASTPRKARASESTAR 995
Query: 622 APASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPAS 662
+ +S++ DE+ PAT P + V P + AP AS
Sbjct: 996 SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKAS 1036
Score = 37.7 bits (86), Expect = 0.034
Identities = 41/153 (26%), Positives = 62/153 (40%), Gaps = 16/153 (10%)
Query: 518 EATTASIATTLSSTSLSIPERS-PSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQIT 576
EA TA L+ST+ S+ PS E+ + T+ +G+ G P + + +
Sbjct: 95 EAETAKATPRLASTNSSVLGADLPSSMKEKAK--AETEKAGKTGNSMPHPATGKTVANLL 152
Query: 577 V------QVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
EP+ + +V EE+ V A GA+A + +A QA D S +SDE
Sbjct: 153 SGKSPRKSAEPSANTTLVSETEEEGSVPA--FGAAAKPGMVSAGQA-DSSSEDTSSSSDE 209
Query: 631 EDAPATDIYFPTDER----SWVYSPLHYSAQAP 659
D P + S SP +A AP
Sbjct: 210 TDVEGKPSVKPAQVKASSVSTKESPARKAAPAP 242
Score = 34.7 bits (78), Expect = 0.29
Identities = 43/212 (20%), Positives = 79/212 (37%), Gaps = 17/212 (8%)
Query: 452 SSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL-P 510
++P+ G+ GA+ + G S S E +++ + A++ + G+ +
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQAKASGKTSQVGA 373
Query: 511 CTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEE 570
+ P+ E + T ++ + + E +QSS ++ +EE PA+
Sbjct: 374 ASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED------SQSSSEESDSEEEAPAQA 427
Query: 571 DLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
QV A + P++ A G +AA +V+ Q D + SD
Sbjct: 428 KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA-QVQVGKQEEDSRSSSEESDSDR 486
Query: 631 EDAPATDIYFPTDERSWVYSPLHYSAQAPPAS 662
E A + + PL S Q PAS
Sbjct: 487 EALAAMN--------AAQVKPLGKSPQVKPAS 510
Score = 33.9 bits (76), Expect = 0.50
Identities = 33/152 (21%), Positives = 50/152 (32%), Gaps = 26/152 (17%)
Query: 513 PPSFEEATTASIATTLSSTSLSIPERSPSETS---------EQPRYRRRTQSSGQDGRPQ 563
P + A S+ L + S P + P + + E+P + D
Sbjct: 561 PTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADS 620
Query: 564 EEPPAEEDLQQ----ITVQVEPACS-------------VEIVVPKEEDAGVEASPAGASA 606
EE PA Q + + AC V + AG SPAG+S
Sbjct: 621 EEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP 680
Query: 607 AVEVETASQASDEEGAPASQASDEEDAPATDI 638
AV T A D + S + +E+ A +
Sbjct: 681 AVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
Score = 32.7 bits (73), Expect = 1.1
Identities = 48/210 (22%), Positives = 82/210 (39%), Gaps = 28/210 (13%)
Query: 448 SSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSERE--EAQYDLRGARSYPTLEDEGR 505
SS + S S++ L VKP G T A+ P++ + ++ P+ G+
Sbjct: 870 SSEEESDSEE-EAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 928
Query: 506 PDLLPCTPPSFEEATTASIATTLSSTSLSI--------PERSPS---------ETSEQPR 548
D + S EE+ + A +++ I P RSP+ + + PR
Sbjct: 929 QD---DSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 549 YRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGV--EASPAGASA 606
R ++S+ + + E +ED+ T + P +V + +AS AGAS+
Sbjct: 986 KARASESTARSSSSESE---DEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASS 1042
Query: 607 AVEVETASQASDEEGAPASQASDEEDAPAT 636
+ E S +EG S PAT
Sbjct: 1043 SKESSRISDGKKQEGPATQVDSAVGTLPAT 1072
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 41.2 bits (95), Expect = 0.003
Identities = 46/221 (20%), Positives = 78/221 (35%), Gaps = 8/221 (3%)
Query: 445 RKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEG 504
+++ S P + + +LA P + A ++ + + G+ + +E
Sbjct: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
Query: 505 RPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQE 564
L P A++A S P +T + SG +
Sbjct: 881 AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESD 940
Query: 565 ---EPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEG 621
E PA Q+ ++P + V P AG A+PA A AA A +
Sbjct: 941 SDGEAPAAVTSAQV---IKPP--LIFVDPNRSPAGPAATPAQAQAASTPRKARASESTAR 995
Query: 622 APASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPAS 662
+ +S++ DE+ PAT P + V P + AP AS
Sbjct: 996 SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKAS 1036
Score = 37.7 bits (86), Expect = 0.034
Identities = 41/153 (26%), Positives = 62/153 (40%), Gaps = 16/153 (10%)
Query: 518 EATTASIATTLSSTSLSIPERS-PSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQIT 576
EA TA L+ST+ S+ PS E+ + T+ +G+ G P + + +
Sbjct: 95 EAETAKATPRLASTNSSVLGADLPSSMKEKAK--AETEKAGKTGNSMPHPATGKTVANLL 152
Query: 577 V------QVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
EP+ + +V EE+ V A GA+A + +A QA D S +SDE
Sbjct: 153 SGKSPRKSAEPSANTTLVSETEEEGSVPA--FGAAAKPGMVSAGQA-DSSSEDTSSSSDE 209
Query: 631 EDAPATDIYFPTDER----SWVYSPLHYSAQAP 659
D P + S SP +A AP
Sbjct: 210 TDVEGKPSVKPAQVKASSVSTKESPARKAAPAP 242
Score = 35.0 bits (79), Expect = 0.22
Identities = 49/207 (23%), Positives = 85/207 (41%), Gaps = 29/207 (14%)
Query: 448 SSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSERE--EAQYDLRGARSYPTLEDEGR 505
SS + S S++ L VKP G T A+ P++ + ++ P+ G+
Sbjct: 870 SSEEESDSEE-EAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 928
Query: 506 PDLLPCTPPSFEEATTASIATTLSSTSLSI--------PERSPS---------ETSEQPR 548
D + S EE+ + A +++ I P RSP+ + + PR
Sbjct: 929 QD---DSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 549 YRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGV--EASPAGASA 606
R ++S+ + + E +ED+ T + P +V + +AS AGAS+
Sbjct: 986 KARASESTARSSSSESE---DEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASS 1042
Query: 607 AVEVETASQASDEEGAPASQASDEEDA 633
+ E S +EG PA+Q S + A
Sbjct: 1043 SKESSRISDGKKQEG-PATQVSKKNPA 1068
Score = 34.7 bits (78), Expect = 0.29
Identities = 43/212 (20%), Positives = 79/212 (37%), Gaps = 17/212 (8%)
Query: 452 SSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL-P 510
++P+ G+ GA+ + G S S E +++ + A++ + G+ +
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQAKASGKTSQVGA 373
Query: 511 CTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEE 570
+ P+ E + T ++ + + E +QSS ++ +EE PA+
Sbjct: 374 ASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED------SQSSSEESDSEEEAPAQA 427
Query: 571 DLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
QV A + P++ A G +AA +V+ Q D + SD
Sbjct: 428 KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA-QVQVGKQEEDSRSSSEESDSDR 486
Query: 631 EDAPATDIYFPTDERSWVYSPLHYSAQAPPAS 662
E A + + PL S Q PAS
Sbjct: 487 EALAAMN--------AAQVKPLGKSPQVKPAS 510
Score = 33.9 bits (76), Expect = 0.50
Identities = 33/152 (21%), Positives = 50/152 (32%), Gaps = 26/152 (17%)
Query: 513 PPSFEEATTASIATTLSSTSLSIPERSPSETS---------EQPRYRRRTQSSGQDGRPQ 563
P + A S+ L + S P + P + + E+P + D
Sbjct: 561 PTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADS 620
Query: 564 EEPPAEEDLQQ----ITVQVEPACS-------------VEIVVPKEEDAGVEASPAGASA 606
EE PA Q + + AC V + AG SPAG+S
Sbjct: 621 EEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP 680
Query: 607 AVEVETASQASDEEGAPASQASDEEDAPATDI 638
AV T A D + S + +E+ A +
Sbjct: 681 AVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 41.2 bits (95), Expect = 0.003
Identities = 46/221 (20%), Positives = 78/221 (35%), Gaps = 8/221 (3%)
Query: 445 RKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEG 504
+++ S P + + +LA P + A ++ + + G+ + +E
Sbjct: 744 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 803
Query: 505 RPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQE 564
L P A++A S P +T + SG +
Sbjct: 804 AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESD 863
Query: 565 ---EPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEG 621
E PA Q+ ++P + V P AG A+PA A AA A +
Sbjct: 864 SDGEAPAAVTSAQV---IKPP--LIFVDPNRSPAGPAATPAQAQAASTPRKARASESTAR 918
Query: 622 APASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPAS 662
+ +S++ DE+ PAT P + V P + AP AS
Sbjct: 919 SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKAS 959
Score = 36.2 bits (82), Expect = 0.10
Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 12/122 (9%)
Query: 518 EATTASIATTLSSTSLSIPERS-PSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQIT 576
EA TA L+ST+ S+ PS E+ + T+ +G+ G P + + +
Sbjct: 95 EAETAKATPRLASTNSSVLGADLPSSMKEKAK--AETEKAGKTGNSMPHPATGKTVANLL 152
Query: 577 V------QVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
EP+ + +V EE+ V A GA+A + +A QA D S +SDE
Sbjct: 153 SGKSPRKSAEPSANTTLVSETEEEGSVPA--FGAAAKPGMVSAGQA-DSSSEDTSSSSDE 209
Query: 631 ED 632
D
Sbjct: 210 TD 211
Score = 35.0 bits (79), Expect = 0.22
Identities = 49/207 (23%), Positives = 85/207 (41%), Gaps = 29/207 (14%)
Query: 448 SSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSERE--EAQYDLRGARSYPTLEDEGR 505
SS + S S++ L VKP G T A+ P++ + ++ P+ G+
Sbjct: 793 SSEEESDSEE-EAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 851
Query: 506 PDLLPCTPPSFEEATTASIATTLSSTSLSI--------PERSPS---------ETSEQPR 548
D + S EE+ + A +++ I P RSP+ + + PR
Sbjct: 852 QD---DSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 908
Query: 549 YRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGV--EASPAGASA 606
R ++S+ + + E +ED+ T + P +V + +AS AGAS+
Sbjct: 909 KARASESTARSSSSESE---DEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASS 965
Query: 607 AVEVETASQASDEEGAPASQASDEEDA 633
+ E S +EG PA+Q S + A
Sbjct: 966 SKESSRISDGKKQEG-PATQVSKKNPA 991
Score = 34.7 bits (78), Expect = 0.29
Identities = 43/212 (20%), Positives = 79/212 (37%), Gaps = 17/212 (8%)
Query: 452 SSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL-P 510
++P+ G+ GA+ + G S S E +++ + A++ + G+ +
Sbjct: 238 ATPAPPGKAGAVASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQAKASGKTSQVGA 296
Query: 511 CTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEE 570
+ P+ E + T ++ + + E +QSS ++ +EE PA+
Sbjct: 297 ASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED------SQSSSEESDSEEEAPAQA 350
Query: 571 DLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
QV A + P++ A G +AA +V+ Q D + SD
Sbjct: 351 KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA-QVQVGKQEEDSRSSSEESDSDR 409
Query: 631 EDAPATDIYFPTDERSWVYSPLHYSAQAPPAS 662
E A + + PL S Q PAS
Sbjct: 410 EALAAMN--------AAQVKPLGKSPQVKPAS 433
Score = 33.9 bits (76), Expect = 0.50
Identities = 33/152 (21%), Positives = 50/152 (32%), Gaps = 26/152 (17%)
Query: 513 PPSFEEATTASIATTLSSTSLSIPERSPSETS---------EQPRYRRRTQSSGQDGRPQ 563
P + A S+ L + S P + P + + E+P + D
Sbjct: 484 PTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADS 543
Query: 564 EEPPAEEDLQQ----ITVQVEPACS-------------VEIVVPKEEDAGVEASPAGASA 606
EE PA Q + + AC V + AG SPAG+S
Sbjct: 544 EEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP 603
Query: 607 AVEVETASQASDEEGAPASQASDEEDAPATDI 638
AV T A D + S + +E+ A +
Sbjct: 604 AVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 635
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 41.2 bits (95), Expect = 0.003
Identities = 46/221 (20%), Positives = 78/221 (35%), Gaps = 8/221 (3%)
Query: 445 RKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEG 504
+++ S P + + +LA P + A ++ + + G+ + +E
Sbjct: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
Query: 505 RPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQE 564
L P A++A S P +T + SG +
Sbjct: 881 AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESD 940
Query: 565 ---EPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEG 621
E PA Q+ ++P + V P AG A+PA A AA A +
Sbjct: 941 SDGEAPAAVTSAQV---IKPP--LIFVDPNRSPAGPAATPAQAQAASTPRKARASESTAR 995
Query: 622 APASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPAS 662
+ +S++ DE+ PAT P + V P + AP AS
Sbjct: 996 SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKAS 1036
Score = 37.7 bits (86), Expect = 0.034
Identities = 41/153 (26%), Positives = 62/153 (40%), Gaps = 16/153 (10%)
Query: 518 EATTASIATTLSSTSLSIPERS-PSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQIT 576
EA TA L+ST+ S+ PS E+ + T+ +G+ G P + + +
Sbjct: 95 EAETAKATPRLASTNSSVLGADLPSSMKEKAK--AETEKAGKTGNSMPHPATGKTVANLL 152
Query: 577 V------QVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
EP+ + +V EE+ V A GA+A + +A QA D S +SDE
Sbjct: 153 SGKSPRKSAEPSANTTLVSETEEEGSVPA--FGAAAKPGMVSAGQA-DSSSEDTSSSSDE 209
Query: 631 EDAPATDIYFPTDER----SWVYSPLHYSAQAP 659
D P + S SP +A AP
Sbjct: 210 TDVEGKPSVKPAQVKASSVSTKESPARKAAPAP 242
Score = 34.7 bits (78), Expect = 0.29
Identities = 43/212 (20%), Positives = 79/212 (37%), Gaps = 17/212 (8%)
Query: 452 SSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL-P 510
++P+ G+ GA+ + G S S E +++ + A++ + G+ +
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQAKASGKTSQVGA 373
Query: 511 CTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEE 570
+ P+ E + T ++ + + E +QSS ++ +EE PA+
Sbjct: 374 ASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED------SQSSSEESDSEEEAPAQA 427
Query: 571 DLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
QV A + P++ A G +AA +V+ Q D + SD
Sbjct: 428 KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA-QVQVGKQEEDSRSSSEESDSDR 486
Query: 631 EDAPATDIYFPTDERSWVYSPLHYSAQAPPAS 662
E A + + PL S Q PAS
Sbjct: 487 EALAAMN--------AAQVKPLGKSPQVKPAS 510
Score = 33.9 bits (76), Expect = 0.50
Identities = 33/152 (21%), Positives = 50/152 (32%), Gaps = 26/152 (17%)
Query: 513 PPSFEEATTASIATTLSSTSLSIPERSPSETS---------EQPRYRRRTQSSGQDGRPQ 563
P + A S+ L + S P + P + + E+P + D
Sbjct: 561 PTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADS 620
Query: 564 EEPPAEEDLQQ----ITVQVEPACS-------------VEIVVPKEEDAGVEASPAGASA 606
EE PA Q + + AC V + AG SPAG+S
Sbjct: 621 EEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP 680
Query: 607 AVEVETASQASDEEGAPASQASDEEDAPATDI 638
AV T A D + S + +E+ A +
Sbjct: 681 AVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
Score = 32.7 bits (73), Expect = 1.1
Identities = 48/210 (22%), Positives = 82/210 (39%), Gaps = 28/210 (13%)
Query: 448 SSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSERE--EAQYDLRGARSYPTLEDEGR 505
SS + S S++ L VKP G T A+ P++ + ++ P+ G+
Sbjct: 870 SSEEESDSEE-EAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 928
Query: 506 PDLLPCTPPSFEEATTASIATTLSSTSLSI--------PERSPS---------ETSEQPR 548
D + S EE+ + A +++ I P RSP+ + + PR
Sbjct: 929 QD---DSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 549 YRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGV--EASPAGASA 606
R ++S+ + + E +ED+ T + P +V + +AS AGAS+
Sbjct: 986 KARASESTARSSSSESE---DEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASS 1042
Query: 607 AVEVETASQASDEEGAPASQASDEEDAPAT 636
+ E S +EG S PAT
Sbjct: 1043 SKESSRISDGKKQEGPATQVDSAVGTLPAT 1072
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 40.8 bits (94), Expect = 0.004
Identities = 46/188 (24%), Positives = 72/188 (38%), Gaps = 12/188 (6%)
Query: 483 EREEAQYDLRGAR--SYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSP 540
E EA+ D + A + P ED P+ P E+ T + S E
Sbjct: 1852 EAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGA-EAPE 1910
Query: 541 SETSEQPRYR--RRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVE 598
+E QP ++ G+D P+ E ++ ++ + E E V + ++A E
Sbjct: 1911 AEKEAQPETESVEALETEGED-EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE 1969
Query: 599 ASPAGASA-AVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQ 657
A P A+EVE +Q ++ E P S ED A + E P +
Sbjct: 1970 AQPESEDVEALEVEVETQEAEGEAQPES-----EDVEAPEAEGEMQEAEEEAQPESDGVE 2024
Query: 658 APPASDGE 665
A P S+GE
Sbjct: 2025 AQPKSEGE 2032
Score = 38.1 bits (87), Expect = 0.026
Identities = 46/190 (24%), Positives = 69/190 (36%), Gaps = 11/190 (5%)
Query: 483 EREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFE-EATTASIATTLSSTSLSIPE---- 537
+++ Q D P E E +P+ P E +A A S + PE
Sbjct: 1823 DQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGE 1882
Query: 538 -RSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAG 596
+ SE E P Q + E P AE++ Q T VE + P+ E A
Sbjct: 1883 AQPESEDVETPEAEWEVQPESEGA---EAPEAEKEAQPETESVEALETEGEDEPESEGAE 1939
Query: 597 V-EASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYS 655
EA A A + + S+ + + A + ED A ++ T E P
Sbjct: 1940 AQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESED 1999
Query: 656 AQAPPASDGE 665
+AP A +GE
Sbjct: 2000 VEAPEA-EGE 2008
Score = 31.6 bits (70), Expect = 2.5
Identities = 42/188 (22%), Positives = 70/188 (37%), Gaps = 30/188 (15%)
Query: 458 GRGGALLAVKP--LGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPS 515
G GG+ + P + T +++P + + D R S LE++ + C P+
Sbjct: 1206 GSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQ-----CCFPT 1260
Query: 516 FEEATTASIATT------------LSSTSLSIPERSPSETSEQPRYRRRTQSSG--QDGR 561
F A + AT SS + E + E + + T+ G ++
Sbjct: 1261 FLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV 1320
Query: 562 PQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEG 621
EE EE LQ+ VQ+E E +EE+A +E ET + EEG
Sbjct: 1321 QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIE---------ETGGEGLQEEG 1371
Query: 622 APASQASD 629
+ +
Sbjct: 1372 VQLEEVKE 1379
Score = 30.4 bits (67), Expect = 5.5
Identities = 40/172 (23%), Positives = 64/172 (37%), Gaps = 33/172 (19%)
Query: 478 SQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATT------LSST 531
++ P +EAQ + + T E E P+ EEA + T + S
Sbjct: 1906 AEAPEAEKEAQPETESVEALET-EGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQ 1964
Query: 532 SLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEE----PPAEEDLQQITVQVEPACSVEI 587
+ SE E TQ + + +P+ E P AE ++Q+
Sbjct: 1965 EAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEA------------ 2012
Query: 588 VVPKEEDA-----GVEASP-AGASAAVEVETASQASDEEGAPASQASDEEDA 633
EE+A GVEA P + A EVE +Q ++ + P S + +A
Sbjct: 2013 ----EEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEA 2060
>gi|49472835 bridging integrator 2 [Homo sapiens]
Length = 565
Score = 40.0 bits (92), Expect = 0.007
Identities = 49/196 (25%), Positives = 77/196 (39%), Gaps = 34/196 (17%)
Query: 452 SSPSKKGRGGALLAVKPLGPTAAFSA--SQIPSEREEAQYDLRGARSYPTLEDEGRP--- 506
S+ S K ++ A + L P AA S+I EE + + G+ + + EDE P
Sbjct: 282 STLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACN 341
Query: 507 ------------------DLLPC-TPPSFEEATTASIATTLSSTSLSIPERSPSETSEQP 547
++LP T PS A + S + S+T + + R+ SE SEQP
Sbjct: 342 GPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQP 401
Query: 548 RYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAA 607
+ R Q + PP+ + T P+ +P A SP A+
Sbjct: 402 KKRASIQRT-------SAPPSRPPPPRATASPRPSSG---NIPSSPTASGGGSPTSPRAS 451
Query: 608 VEVETASQASDEEGAP 623
+ TAS + E +P
Sbjct: 452 LGTGTASPRTSLEVSP 467
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 39.7 bits (91), Expect = 0.009
Identities = 52/199 (26%), Positives = 74/199 (37%), Gaps = 37/199 (18%)
Query: 471 PTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATT--ASIATTL 528
P A S + EEA +++ + +E +L PPS EE T AS A L
Sbjct: 539 PAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLEL---QPPSGEETTAEEASAAIQL 595
Query: 529 SSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIV 588
+ + + E +P+E + PPAEE ++ E+
Sbjct: 596 LAATEASAEEAPAEV--------------------QPPPAEEAPAEVQPPPAEEAPAEVQ 635
Query: 589 VPKEEDAGVEASPAGASAAVEVETASQASDEEGAPAS-QASDEEDAPATDIYFPTDERSW 647
P E+A E P A E Q E APA Q E+APA P +E
Sbjct: 636 PPPAEEAPAEVQPPPAE---EAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQSLPAEE--- 689
Query: 648 VYSPLHYSAQA---PPASD 663
+P+ + A PPA D
Sbjct: 690 --TPIEETLAAVHSPPADD 706
Score = 37.7 bits (86), Expect = 0.034
Identities = 46/160 (28%), Positives = 69/160 (43%), Gaps = 27/160 (16%)
Query: 513 PPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAE--E 570
PP+ EE TL+ +PE +P E + R Q S P EE P E
Sbjct: 414 PPTVEE--------TLADVQPLLPEEAPREEA------RELQLSTAMETPAEEAPTEFQS 459
Query: 571 DLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVET-ASQASDEEGAPASQASD 629
L + T E + ++++ E A + +PA A + + ET A +A E +P ++ +
Sbjct: 460 PLPKETTAEEASAEIQLLAATEPPA--DETPAEARSPLSEETSAEEAHAEVQSPLAEETT 517
Query: 630 EEDAPA-----TDIYFPTDER-SWVYSPL--HYSAQAPPA 661
E+A A I P DE + SPL SA+ PA
Sbjct: 518 AEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPA 557
Score = 35.4 bits (80), Expect = 0.17
Identities = 42/183 (22%), Positives = 74/183 (40%), Gaps = 22/183 (12%)
Query: 485 EEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETS 544
+E + R S T +E ++ P EE T + + L+ E ET
Sbjct: 485 DETPAEARSPLSEETSAEEAHAEV---QSPLAEETTAEEASAEIQL--LAAIEAPADETP 539
Query: 545 EQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGA 604
+ + ++S ++ + + P+ + V +E A +E+ P E+ E A
Sbjct: 540 AEAQSPLSEETSAEEAPAEVQSPSAKG-----VSIEEA-PLELQPPSGEETTAEE----A 589
Query: 605 SAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPASDG 664
SAA+++ A++AS EE Q E+APA P +E Q PPA +
Sbjct: 590 SAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAP-------AEVQPPPAEEA 642
Query: 665 ESD 667
++
Sbjct: 643 PAE 645
>gi|126090892 aggrecan isoform 2 precursor [Homo sapiens]
Length = 2416
Score = 38.9 bits (89), Expect = 0.015
Identities = 55/223 (24%), Positives = 81/223 (36%), Gaps = 14/223 (6%)
Query: 450 LKSSPSKKGRGGALLAVKPLGPTAAFSASQIP-SEREEAQYDLRG----ARSYPTLEDEG 504
L S K G + P+ P + S +P S E + Y G A + ED G
Sbjct: 1952 LFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSG 2011
Query: 505 RPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQD--GRP 562
PDL T E S +S ++L+ E S E T G + G P
Sbjct: 2012 SPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLP 2071
Query: 563 QEEPPAEEDLQQITVQVEPACS---VEIVVPKEEDAGVEASPAGASAAVEVETASQA-SD 618
P A D +I+ + S V I E + + A +E+E++S S
Sbjct: 2072 SATPTASGDRTEISGDLSGHTSQLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSG 2131
Query: 619 EEGAPASQASDEEDA--PATDIYFPTDERSWVYSPLHYSAQAP 659
EE A+ DA PA+ + + S +P A+ P
Sbjct: 2132 EETHTVETATSPTDASIPASP-EWKRESESTAAAPARSCAEEP 2173
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 38.9 bits (89), Expect = 0.015
Identities = 48/204 (23%), Positives = 83/204 (40%), Gaps = 27/204 (13%)
Query: 479 QIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPER 538
++P E + L G S ED G+ P + EE + + + + +L P+
Sbjct: 127 KLPGSDSENEELLNGHASDSENEDVGKH---PASDSEIEELQKSPASDSETEDALK-PQI 182
Query: 539 SPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITV-----------QVEPACSVEI 587
S SE+ E PR++ + + +P+ E+L + V Q + + E+
Sbjct: 183 SDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEEL 242
Query: 588 VVPKEEDAGVEASPAGASAAVEVETASQA----SDEEGAPASQASDEEDAPATDIYFPTD 643
P+ D+ E P ++ E E + S+ E P +QASD E+ ++ P
Sbjct: 243 PKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSEN---EELPKPRV 299
Query: 644 ERSWVYSPLHYSAQAPPASDGESD 667
S P Q PASD E++
Sbjct: 300 SDSESEGP-----QKGPASDSETE 318
>gi|126090883 aggrecan isoform 1 precursor [Homo sapiens]
Length = 2317
Score = 38.5 bits (88), Expect = 0.020
Identities = 49/195 (25%), Positives = 70/195 (35%), Gaps = 11/195 (5%)
Query: 450 LKSSPSKKGRGGALLAVKPLGPTAAFSASQIP-SEREEAQYDLRG----ARSYPTLEDEG 504
L S K G + P+ P + S +P S E + Y G A + ED G
Sbjct: 1952 LFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSG 2011
Query: 505 RPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQD--GRP 562
PDL T E S +S ++L+ E S E T G + G P
Sbjct: 2012 SPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLP 2071
Query: 563 QEEPPAEEDLQQITVQVEPACS---VEIVVPKEEDAGVEASPAGASAAVEVETASQA-SD 618
P A D +I+ + S V I E + + A +E+E++S S
Sbjct: 2072 SATPTASGDRTEISGDLSGHTSQLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSG 2131
Query: 619 EEGAPASQASDEEDA 633
EE A+ DA
Sbjct: 2132 EETHTVETATSPTDA 2146
>gi|58530876 melanoma antigen family C, 1 [Homo sapiens]
Length = 1142
Score = 37.7 bits (86), Expect = 0.034
Identities = 51/229 (22%), Positives = 77/229 (33%), Gaps = 33/229 (14%)
Query: 471 PTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASI---ATT 527
P + Q P E E L+ S P ED P P +PP E++ + +
Sbjct: 510 PQSPLQIPQSPPEGENTHSPLQIVPSLPEWEDSLSPHYFPQSPPQGEDSLSPHYFPQSPP 569
Query: 528 LSSTSLS---IPERSPSETSEQPRYRRRTQSSGQDGR-----PQEEPPAEEDLQQITVQV 579
SLS P+ E S P Y ++ G+D PQ EE + V
Sbjct: 570 QGEDSLSPHYFPQSPQGEDSLSPHYFPQSPPQGEDSMSPLYFPQSPLQGEEFQSSLQSPV 629
Query: 580 E-PACSVEIVVPKEEDAGVEASPAG---------ASAAVEVETASQASDEEGAPAS---- 625
+ S +P+ ++ P G S + + S E AP
Sbjct: 630 SICSSSTPSSLPQSFPESSQSPPEGPVQSPLHSPQSPPEGMHSQSPLQSPESAPEGEDSL 689
Query: 626 ------QASDEEDAPATDIYFPTDERSW--VYSPLHYSAQAPPASDGES 666
Q+ E + + ++FP W SPLH+ P D +S
Sbjct: 690 SPLQIPQSPLEGEDSLSSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQS 738
Score = 36.6 bits (83), Expect = 0.077
Identities = 44/192 (22%), Positives = 73/192 (38%), Gaps = 31/192 (16%)
Query: 479 QIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPS---FEEATTASIATTLSSTSLSI 535
Q P E E++ L +S P ED P P PP F+ + + ++ SSTSLS+
Sbjct: 696 QSPLEGEDSLSSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQSSLQSPVSICSSSTSLSL 755
Query: 536 PE------RSPSETSEQPRYRRRT------------QSSGQDGRPQEEPPAEEDLQQITV 577
P+ +SP E Q +R QSS + + E PA+ LQ
Sbjct: 756 PQSFPESPQSPPEGPAQSPLQRPVSSFFSYTLASLLQSSHESPQSPPEGPAQSPLQSPVS 815
Query: 578 QVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQ------ASDEEGAPASQASDEE 631
+ S + + + V + P+ S+++ + S S S+E
Sbjct: 816 SFPSSTSSSL----SQSSPVSSFPSSTSSSLSKSSPESPLQSPVISFSSSTSLSPFSEES 871
Query: 632 DAPATDIYFPTD 643
+P + +D
Sbjct: 872 SSPVDEYTSSSD 883
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 37.7 bits (86), Expect = 0.034
Identities = 41/153 (26%), Positives = 62/153 (40%), Gaps = 16/153 (10%)
Query: 518 EATTASIATTLSSTSLSIPERS-PSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQIT 576
EA TA L+ST+ S+ PS E+ + T+ +G+ G P + + +
Sbjct: 95 EAETAKATPRLASTNSSVLGADLPSSMKEKAK--AETEKAGKTGNSMPHPATGKTVANLL 152
Query: 577 V------QVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
EP+ + +V EE+ V A GA+A + +A QA D S +SDE
Sbjct: 153 SGKSPRKSAEPSANTTLVSETEEEGSVPA--FGAAAKPGMVSAGQA-DSSSEDTSSSSDE 209
Query: 631 EDAPATDIYFPTDER----SWVYSPLHYSAQAP 659
D P + S SP +A AP
Sbjct: 210 TDVEGKPSVKPAQVKASSVSTKESPARKAAPAP 242
Score = 34.7 bits (78), Expect = 0.29
Identities = 43/212 (20%), Positives = 79/212 (37%), Gaps = 17/212 (8%)
Query: 452 SSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL-P 510
++P+ G+ GA+ + G S S E +++ + A++ + G+ +
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQAKASGKTSQVGA 373
Query: 511 CTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEE 570
+ P+ E + T ++ + + E +QSS ++ +EE PA+
Sbjct: 374 ASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED------SQSSSEESDSEEEAPAQA 427
Query: 571 DLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDE 630
QV A + P++ A G +AA +V+ Q D + SD
Sbjct: 428 KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA-QVQVGKQEEDSRSSSEESDSDR 486
Query: 631 EDAPATDIYFPTDERSWVYSPLHYSAQAPPAS 662
E A + + PL S Q PAS
Sbjct: 487 EALAAMN--------AAQVKPLGKSPQVKPAS 510
Score = 33.9 bits (76), Expect = 0.50
Identities = 33/152 (21%), Positives = 50/152 (32%), Gaps = 26/152 (17%)
Query: 513 PPSFEEATTASIATTLSSTSLSIPERSPSETS---------EQPRYRRRTQSSGQDGRPQ 563
P + A S+ L + S P + P + + E+P + D
Sbjct: 561 PTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADS 620
Query: 564 EEPPAEEDLQQ----ITVQVEPACS-------------VEIVVPKEEDAGVEASPAGASA 606
EE PA Q + + AC V + AG SPAG+S
Sbjct: 621 EEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP 680
Query: 607 AVEVETASQASDEEGAPASQASDEEDAPATDI 638
AV T A D + S + +E+ A +
Sbjct: 681 AVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
Length = 1444
Score = 37.7 bits (86), Expect = 0.034
Identities = 86/373 (23%), Positives = 126/373 (33%), Gaps = 75/373 (20%)
Query: 322 GVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIP 381
G H ++ E EKRP +K ++ G GE S T+ P
Sbjct: 581 GAHLEEKKTPESSLSSQHLNELEKRPNPEKV--------VEEGREAGEMESS--TLQESP 630
Query: 382 AVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSN 441
R E +LLH D L + +++ K + + + S+ P+
Sbjct: 631 --RARAEAVLLHEMDEDDLANALIWPEIQQELKIIESEEELSSLPPPA------------ 676
Query: 442 TVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSE---------REEAQYDLR 492
LK+SP + +L P P + P+ R+ A +
Sbjct: 677 --------LKTSPIQPILESSLGPFIPSEPPGSLPCGSFPAPVSTPLEVWTRDPANQSTQ 728
Query: 493 GA-----RSYPTLEDEGRPDLLPCTPPS---FEEATTASIATTLSSTSLSIPERSPSETS 544
GA R P E PDL P FE+A+ + +LS P P+
Sbjct: 729 GASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGPGNLS-PPLPPAPPP 787
Query: 545 EQPRYRRRTQSSGQDGRPQEEPPAEE---DL------QQITVQVEPACSVEIVVPKEED- 594
P T G P+ E + + DL Q + ++ C E P+ D
Sbjct: 788 PTP-LEESTPVLLSKGGPEREDSSRKLRTDLYIDQLKSQDSPEISSLCQGEEATPRHSDK 846
Query: 595 -----AGVEASPAG-ASAAVEVETASQASDEEGAPASQASD-EEDAPATDI-------YF 640
A E G S EVE SQ ++ + SD +ED TDI
Sbjct: 847 QNSKNAASEGKGCGFPSPTREVEIVSQEEEDVTHSVQEPSDCDEDDTVTDIAQHGLEMVE 906
Query: 641 PTDERSWVYSPLH 653
P +E WV SPLH
Sbjct: 907 PWEEPQWVTSPLH 919
>gi|239756116 PREDICTED: hypothetical protein [Homo sapiens]
Length = 194
Score = 37.4 bits (85), Expect = 0.045
Identities = 29/108 (26%), Positives = 47/108 (43%), Gaps = 11/108 (10%)
Query: 521 TASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVE 580
++ ++T LS +LS+P +E+P R R G+ P E P + + +
Sbjct: 14 SSRVSTLLSPRALSLP-------AEEPHARLREDKQGEPPPPGEFSPPGDGSSTLPGG-D 65
Query: 581 PACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQAS 628
PAC ++ P G +SPA A + + E APA+Q S
Sbjct: 66 PACLLKSCSP---GLGTRSSPAAAGGGATSGSPRVVTPEPAAPATQVS 110
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,296,185
Number of Sequences: 37866
Number of extensions: 1344039
Number of successful extensions: 5318
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 199
Number of HSP's that attempted gapping in prelim test: 4858
Number of HSP's gapped (non-prelim): 604
length of query: 668
length of database: 18,247,518
effective HSP length: 109
effective length of query: 559
effective length of database: 14,120,124
effective search space: 7893149316
effective search space used: 7893149316
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.