BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|30795215 cell cycle related kinase isoform 2 [Homo sapiens] (325 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|30795215 cell cycle related kinase isoform 2 [Homo sapiens] 660 0.0 gi|30795255 cell cycle related kinase isoform 1 [Homo sapiens] 651 0.0 gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 648 0.0 gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 219 3e-57 gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 202 3e-52 gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 201 6e-52 gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 201 6e-52 gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 200 2e-51 gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens] 194 7e-50 gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 192 3e-49 gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 191 6e-49 gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 191 6e-49 gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 191 6e-49 gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 191 6e-49 gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 191 6e-49 gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 191 6e-49 gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 191 6e-49 gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 191 6e-49 gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 190 1e-48 gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 190 1e-48 gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 189 3e-48 gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 189 3e-48 gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 180 1e-45 gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 178 5e-45 gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 178 5e-45 gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 178 5e-45 gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 177 1e-44 gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 172 3e-43 gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 167 9e-42 gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 167 9e-42 >gi|30795215 cell cycle related kinase isoform 2 [Homo sapiens] Length = 325 Score = 660 bits (1703), Expect = 0.0 Identities = 325/325 (100%), Positives = 325/325 (100%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120 Query: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRSVGCIMGELLNGS 180 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRSVGCIMGELLNGS Sbjct: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRSVGCIMGELLNGS 180 Query: 181 PLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQA 240 PLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQA Sbjct: 181 PLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQA 240 Query: 241 LDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGGPAPKAHPGPPHIH 300 LDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGGPAPKAHPGPPHIH Sbjct: 241 LDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGGPAPKAHPGPPHIH 300 Query: 301 DFHVDRPLEESLLNPELIRPFILEG 325 DFHVDRPLEESLLNPELIRPFILEG Sbjct: 301 DFHVDRPLEESLLNPELIRPFILEG 325 >gi|30795255 cell cycle related kinase isoform 1 [Homo sapiens] Length = 338 Score = 651 bits (1679), Expect = 0.0 Identities = 325/338 (96%), Positives = 325/338 (96%), Gaps = 13/338 (3%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVE-------------TGEIVALKKVALRRLEDGFPNQ 47 MDQYCILGRIGEGAHGIVFKAKHVE TGEIVALKKVALRRLEDGFPNQ Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVEPRVGWQCLPSILQTGEIVALKKVALRRLEDGFPNQ 60 Query: 48 ALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSY 107 ALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSY Sbjct: 61 ALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSY 120 Query: 108 LQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR 167 LQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR Sbjct: 121 LQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR 180 Query: 168 SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPM 227 SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPM Sbjct: 181 SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPM 240 Query: 228 PLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGG 287 PLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGG Sbjct: 241 PLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGG 300 Query: 288 PAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG 325 PAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG Sbjct: 301 PAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG 338 >gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] Length = 346 Score = 648 bits (1671), Expect = 0.0 Identities = 325/346 (93%), Positives = 325/346 (93%), Gaps = 21/346 (6%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120 Query: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR------------- 167 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR Sbjct: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQ 180 Query: 168 --------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 219 SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI Sbjct: 181 YDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 240 Query: 220 SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSEL 279 SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSEL Sbjct: 241 SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSEL 300 Query: 280 PIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG 325 PIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG Sbjct: 301 PIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG 346 >gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] Length = 305 Score = 219 bits (558), Expect = 3e-57 Identities = 127/305 (41%), Positives = 185/305 (60%), Gaps = 24/305 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 MD + + +IGEG +G+V+KAK+ ETG++VALKK+ L +G P+ A+REI L+E++ Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELK- 59 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQ-RPLAQAQVKSYLQMLLKGVAFCH 119 + +V+L V + L FEF+ DL + + L +KSYL LL+GV+FCH Sbjct: 60 HPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCH 119 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVF-----------------SPD---GSRL 159 ++ ++HRDLKP NLLI+ G +K+ADFGLAR F +P+ GS+ Sbjct: 120 SHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKF 179 Query: 160 YTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 219 YT V S+GCI E++ LFPG ++I+QL + R+LGTP+ WP +T+LPDY K Sbjct: 180 YTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDY-KG 238 Query: 220 SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSEL 279 SF + LEE++P++ P+ DLL Q L Y P QRI A AL H Y F++P P+ + Sbjct: 239 SFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPY-FSSPEPSPAARQ 297 Query: 280 PIPQR 284 + QR Sbjct: 298 YVLQR 302 >gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] Length = 292 Score = 202 bits (514), Expect = 3e-52 Identities = 124/288 (43%), Positives = 165/288 (57%), Gaps = 23/288 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 M +Y L +IGEG +G VFKAK+ ET EIVALK+V L ++G P+ ALREI L+E++ Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK- 59 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120 ++ +V+L V L FEF DL + L VKS+L LLKG+ FCH+ Sbjct: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 Query: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFS-----------------PD---GSRLY 160 N++HRDLKP NLLI+ +G+LK+ADFGLAR F PD G++LY Sbjct: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 Query: 161 THQVATRSVGCIMGELLN-GSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 219 + + S GCI EL N G PLFPG + +QL + R+LGTP + WP +T+LPDY Sbjct: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 Query: 220 SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 267 L V+P ++ DLL L P QRI+A +AL H YF Sbjct: 240 PM-YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 >gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] Length = 297 Score = 201 bits (512), Expect = 6e-52 Identities = 114/290 (39%), Positives = 165/290 (56%), Gaps = 26/290 (8%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 M+ Y + +IGEG +G+V+K +H TG++VA+KK+ L E+G P+ A+REI L+E+ Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR- 59 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQ--RPLAQAQVKSYLQMLLKGVAFC 118 + +V L+ V L FEF+ DL + + + + + VKSYL +L+G+ FC Sbjct: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 Query: 119 HANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR----------- 167 H+ ++HRDLKP NLLI G +K+ADFGLAR F R+YTH+V T Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-IRVYTHEVVTLWYRSPEVLLGS 178 Query: 168 ----------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYN 217 S+G I EL PLF G ++I+QL + R LGTPN +VWPE+ L DY Sbjct: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY- 237 Query: 218 KISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 267 K +F + P L + ++ LDLL + L+Y P +RI+ AL H YF Sbjct: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 >gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] Length = 298 Score = 201 bits (512), Expect = 6e-52 Identities = 118/297 (39%), Positives = 172/297 (57%), Gaps = 27/297 (9%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 M+ + + +IGEG +G+V+KA++ TGE+VALKK+ L +G P+ A+REI L+E+ + Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-N 59 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVV-RHAQRPLAQAQVKSYLQMLLKGVAFCH 119 + +V+L V L FEF+ DL + + A + +KSYL LL+G+AFCH Sbjct: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR------------ 167 ++ ++HRDLKP NLLI+ G +K+ADFGLAR F R YTH+V T Sbjct: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP-VRTYTHEVVTLWYRAPEILLGCK 178 Query: 168 ---------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 218 S+GCI E++ LFPG ++I+QL + R LGTP+ VWP +T +PDY K Sbjct: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY-K 237 Query: 219 ISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF--FTAPLP 273 SF + +V+P + LL Q L Y P++RI+A AL H +F T P+P Sbjct: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 >gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] Length = 297 Score = 200 bits (508), Expect = 2e-51 Identities = 114/289 (39%), Positives = 165/289 (57%), Gaps = 24/289 (8%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 M+ Y + +IGEG +G+V+K +H TG++VA+KK+ L E+G P+ A+REI L+E+ Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR- 59 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQ--RPLAQAQVKSYLQMLLKGVAFC 118 + +V L+ V L FEF+ DL + + + + + VKSYL +L+G+ FC Sbjct: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 Query: 119 HANNIVHRDLKPANLLISASGQLKIADFGLARVF-----------------SPD---GSR 158 H+ ++HRDLKP NLLI G +K+ADFGLAR F SP+ GS Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSA 179 Query: 159 LYTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 218 Y+ V S+G I EL PLF G ++I+QL + R LGTPN +VWPE+ L DY K Sbjct: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY-K 238 Query: 219 ISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 267 +F + P L + ++ LDLL + L+Y P +RI+ AL H YF Sbjct: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 >gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens] Length = 264 Score = 194 bits (494), Expect = 7e-50 Identities = 113/276 (40%), Positives = 165/276 (59%), Gaps = 19/276 (6%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 M+ + + +IGEG +G+V+KA++ TGE+VALKK+ L +G P+ A+REI L+E+ + Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-N 59 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVV-RHAQRPLAQAQVKSYLQMLLKGVAFCH 119 + +V+L V L FEF+ DL + + A + +KSYL LL+G+AFCH Sbjct: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRSVGCIMGELLNG 179 ++ ++HRDLKP NLLI+ G +K+ADFGLAR F R YTH+V R+ Sbjct: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP-VRTYTHEVTRRA----------- 167 Query: 180 SPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQ 239 LFPG ++I+QL + R LGTP+ VWP +T +PDY K SF + +V+P + Sbjct: 168 --LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY-KPSFPKWARQDFSKVVPPLDED 224 Query: 240 ALDLLGQFLLYPPHQRIAASKALLHQYF--FTAPLP 273 LL Q L Y P++RI+A AL H +F T P+P Sbjct: 225 GRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 260 >gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] Length = 346 Score = 192 bits (489), Expect = 3e-49 Identities = 114/304 (37%), Positives = 164/304 (53%), Gaps = 28/304 (9%) Query: 3 QYCILGRIGEGAHGIVFKAKHVETGEIVALKKVAL---RRLEDGFPNQALREIKALQEME 59 +Y L +GEG V+KA+ T +IVA+KK+ L +DG ALREIK LQE+ Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 Query: 60 DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119 + ++ L F H L F+FM +DL +++ L + +K+Y+ M L+G+ + H Sbjct: 71 -HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR------------ 167 + I+HRDLKP NLL+ +G LK+ADFGLA+ F +R YTHQV TR Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG-SPNRAYTHQVVTRWYRAPELLFGAR 188 Query: 168 ---------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 218 +VGCI+ ELL P PG +D++QL + LGTP + WP++ LPDY Sbjct: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY-- 246 Query: 219 ISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSE 278 ++FK +PL + LDL+ L+ P RI A++AL +YF P P + Sbjct: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQ 306 Query: 279 LPIP 282 LP P Sbjct: 307 LPRP 310 >gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform 9 [Homo sapiens] Length = 771 Score = 191 bits (486), Expect = 6e-49 Identities = 113/302 (37%), Positives = 172/302 (56%), Gaps = 22/302 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59 ++++ L RI EG +G+V++AK +T EIVALK++ + + ++GFP +LREI L+ Sbjct: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470 Query: 60 DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119 N V+ V + + ++ DL ++ ++P +VK+ + LL+GV H Sbjct: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 530 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVF-----------------SPD---GSRL 159 N I+HRDLK +NLL+S +G LK+ DFGLAR + +P+ G++ Sbjct: 531 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 590 Query: 160 YTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 219 Y+ V SVGCI GELL PLFPGK++I+Q+ V + LGTP+ ++WP +ELP K+ Sbjct: 591 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 650 Query: 220 SFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSE 278 +F E L + +S Q DL+ +FL Y P +RI+A L H+YF PLP PS Sbjct: 651 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM 710 Query: 279 LP 280 P Sbjct: 711 FP 712 >gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform 8 [Homo sapiens] Length = 780 Score = 191 bits (486), Expect = 6e-49 Identities = 113/302 (37%), Positives = 172/302 (56%), Gaps = 22/302 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59 ++++ L RI EG +G+V++AK +T EIVALK++ + + ++GFP +LREI L+ Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479 Query: 60 DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119 N V+ V + + ++ DL ++ ++P +VK+ + LL+GV H Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 539 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVF-----------------SPD---GSRL 159 N I+HRDLK +NLL+S +G LK+ DFGLAR + +P+ G++ Sbjct: 540 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 599 Query: 160 YTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 219 Y+ V SVGCI GELL PLFPGK++I+Q+ V + LGTP+ ++WP +ELP K+ Sbjct: 600 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 659 Query: 220 SFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSE 278 +F E L + +S Q DL+ +FL Y P +RI+A L H+YF PLP PS Sbjct: 660 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM 719 Query: 279 LP 280 P Sbjct: 720 FP 721 >gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform 5 [Homo sapiens] Length = 748 Score = 191 bits (486), Expect = 6e-49 Identities = 113/302 (37%), Positives = 172/302 (56%), Gaps = 22/302 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59 ++++ L RI EG +G+V++AK +T EIVALK++ + + ++GFP +LREI L+ Sbjct: 388 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 447 Query: 60 DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119 N V+ V + + ++ DL ++ ++P +VK+ + LL+GV H Sbjct: 448 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 507 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVF-----------------SPD---GSRL 159 N I+HRDLK +NLL+S +G LK+ DFGLAR + +P+ G++ Sbjct: 508 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 567 Query: 160 YTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 219 Y+ V SVGCI GELL PLFPGK++I+Q+ V + LGTP+ ++WP +ELP K+ Sbjct: 568 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 627 Query: 220 SFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSE 278 +F E L + +S Q DL+ +FL Y P +RI+A L H+YF PLP PS Sbjct: 628 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM 687 Query: 279 LP 280 P Sbjct: 688 FP 689 >gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform 4 [Homo sapiens] Length = 737 Score = 191 bits (486), Expect = 6e-49 Identities = 113/302 (37%), Positives = 172/302 (56%), Gaps = 22/302 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59 ++++ L RI EG +G+V++AK +T EIVALK++ + + ++GFP +LREI L+ Sbjct: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436 Query: 60 DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119 N V+ V + + ++ DL ++ ++P +VK+ + LL+GV H Sbjct: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 496 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVF-----------------SPD---GSRL 159 N I+HRDLK +NLL+S +G LK+ DFGLAR + +P+ G++ Sbjct: 497 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 556 Query: 160 YTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 219 Y+ V SVGCI GELL PLFPGK++I+Q+ V + LGTP+ ++WP +ELP K+ Sbjct: 557 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 616 Query: 220 SFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSE 278 +F E L + +S Q DL+ +FL Y P +RI+A L H+YF PLP PS Sbjct: 617 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM 676 Query: 279 LP 280 P Sbjct: 677 FP 678 >gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform 3 [Homo sapiens] Length = 526 Score = 191 bits (486), Expect = 6e-49 Identities = 113/302 (37%), Positives = 172/302 (56%), Gaps = 22/302 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59 ++++ L RI EG +G+V++AK +T EIVALK++ + + ++GFP +LREI L+ Sbjct: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225 Query: 60 DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119 N V+ V + + ++ DL ++ ++P +VK+ + LL+GV H Sbjct: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 285 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVF-----------------SPD---GSRL 159 N I+HRDLK +NLL+S +G LK+ DFGLAR + +P+ G++ Sbjct: 286 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 345 Query: 160 YTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 219 Y+ V SVGCI GELL PLFPGK++I+Q+ V + LGTP+ ++WP +ELP K+ Sbjct: 346 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 405 Query: 220 SFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSE 278 +F E L + +S Q DL+ +FL Y P +RI+A L H+YF PLP PS Sbjct: 406 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM 465 Query: 279 LP 280 P Sbjct: 466 FP 467 >gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform 2 [Homo sapiens] Length = 782 Score = 191 bits (486), Expect = 6e-49 Identities = 113/302 (37%), Positives = 172/302 (56%), Gaps = 22/302 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59 ++++ L RI EG +G+V++AK +T EIVALK++ + + ++GFP +LREI L+ Sbjct: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481 Query: 60 DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119 N V+ V + + ++ DL ++ ++P +VK+ + LL+GV H Sbjct: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 541 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVF-----------------SPD---GSRL 159 N I+HRDLK +NLL+S +G LK+ DFGLAR + +P+ G++ Sbjct: 542 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 601 Query: 160 YTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 219 Y+ V SVGCI GELL PLFPGK++I+Q+ V + LGTP+ ++WP +ELP K+ Sbjct: 602 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 661 Query: 220 SFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSE 278 +F E L + +S Q DL+ +FL Y P +RI+A L H+YF PLP PS Sbjct: 662 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM 721 Query: 279 LP 280 P Sbjct: 722 FP 723 >gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] Length = 1512 Score = 191 bits (486), Expect = 6e-49 Identities = 110/313 (35%), Positives = 174/313 (55%), Gaps = 36/313 (11%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 +D++ I+G IGEG +G V+KA+ +TGE+VALKKV L ++GFP A+REIK L+++ Sbjct: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLT- 760 Query: 61 NQYVVQLKAVFPHG----------GGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQM 110 +Q ++ +K + G F L FE+M DL ++ + +KS+++ Sbjct: 761 HQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQ 820 Query: 111 LLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR--- 167 L++G+ +CH N +HRD+K +N+L++ GQ+K+ADFGLAR++S + SR YT++V T Sbjct: 821 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880 Query: 168 ------------------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPE 209 S GCI+GEL P+F ++ QL + RI G+P P VWP+ Sbjct: 881 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 940 Query: 210 LTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFT 269 + +LP +N + K+Q L E + ALDL L P +R A +AL ++ Sbjct: 941 VIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL-- 998 Query: 270 APLPAHPSELPIP 282 PS++P P Sbjct: 999 --RDVEPSKMPPP 1009 >gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] Length = 1452 Score = 191 bits (486), Expect = 6e-49 Identities = 110/313 (35%), Positives = 174/313 (55%), Gaps = 36/313 (11%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 +D++ I+G IGEG +G V+KA+ +TGE+VALKKV L ++GFP A+REIK L+++ Sbjct: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLT- 760 Query: 61 NQYVVQLKAVFPHG----------GGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQM 110 +Q ++ +K + G F L FE+M DL ++ + +KS+++ Sbjct: 761 HQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQ 820 Query: 111 LLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR--- 167 L++G+ +CH N +HRD+K +N+L++ GQ+K+ADFGLAR++S + SR YT++V T Sbjct: 821 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880 Query: 168 ------------------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPE 209 S GCI+GEL P+F ++ QL + RI G+P P VWP+ Sbjct: 881 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 940 Query: 210 LTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFT 269 + +LP +N + K+Q L E + ALDL L P +R A +AL ++ Sbjct: 941 VIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL-- 998 Query: 270 APLPAHPSELPIP 282 PS++P P Sbjct: 999 --RDVEPSKMPPP 1009 >gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2 [Homo sapiens] Length = 1481 Score = 190 bits (483), Expect = 1e-48 Identities = 111/312 (35%), Positives = 174/312 (55%), Gaps = 33/312 (10%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 +D++ I+G IGEG +G V+KAK +TGE+VALKKV L ++GFP A+REIK L+++ Sbjct: 724 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLI- 782 Query: 61 NQYVVQLKAVFPHG----------GGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQM 110 ++ VV +K + G F L FE+M DL ++ ++ +KS+++ Sbjct: 783 HRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQ 842 Query: 111 LLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR--- 167 L++G+ +CH N +HRD+K +N+L++ SGQ+K+ADFGLAR+++ + SR YT++V T Sbjct: 843 LMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYR 902 Query: 168 ------------------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPE 209 S GCI+GEL P+F ++ QL + R+ G+P P VWP+ Sbjct: 903 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPD 962 Query: 210 LTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFT 269 + +LP +N + K+Q L E + ALDLL L P +R A + L + Sbjct: 963 VIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKD 1022 Query: 270 APL-PAHPSELP 280 L P +LP Sbjct: 1023 VELSKMAPPDLP 1034 >gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1 [Homo sapiens] Length = 1490 Score = 190 bits (483), Expect = 1e-48 Identities = 111/312 (35%), Positives = 174/312 (55%), Gaps = 33/312 (10%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 +D++ I+G IGEG +G V+KAK +TGE+VALKKV L ++GFP A+REIK L+++ Sbjct: 724 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLI- 782 Query: 61 NQYVVQLKAVFPHG----------GGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQM 110 ++ VV +K + G F L FE+M DL ++ ++ +KS+++ Sbjct: 783 HRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQ 842 Query: 111 LLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR--- 167 L++G+ +CH N +HRD+K +N+L++ SGQ+K+ADFGLAR+++ + SR YT++V T Sbjct: 843 LMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYR 902 Query: 168 ------------------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPE 209 S GCI+GEL P+F ++ QL + R+ G+P P VWP+ Sbjct: 903 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPD 962 Query: 210 LTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFT 269 + +LP +N + K+Q L E + ALDLL L P +R A + L + Sbjct: 963 VIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKD 1022 Query: 270 APL-PAHPSELP 280 L P +LP Sbjct: 1023 VELSKMAPPDLP 1034 >gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] Length = 770 Score = 189 bits (480), Expect = 3e-48 Identities = 112/302 (37%), Positives = 171/302 (56%), Gaps = 22/302 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59 ++++ L RI EG +G+V++AK +T EIVALK++ + + ++GFP +LREI L+ Sbjct: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469 Query: 60 DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119 N V+ V + + ++ DL ++ ++P +VK+ + LL+GV H Sbjct: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 529 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVF-----------------SPD---GSRL 159 N I+HRDLK +NLL+S +G LK+ DFGLAR + +P+ G++ Sbjct: 530 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKE 589 Query: 160 YTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 219 Y+ V SVGCI GELL PLFPG ++I+Q+ V + LGTP+ ++WP +ELP K+ Sbjct: 590 YSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKM 649 Query: 220 SFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSE 278 +F E L + +S Q DL+ +FL Y P +RI+A L H+YF PLP PS Sbjct: 650 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM 709 Query: 279 LP 280 P Sbjct: 710 FP 711 >gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] Length = 780 Score = 189 bits (480), Expect = 3e-48 Identities = 112/302 (37%), Positives = 171/302 (56%), Gaps = 22/302 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59 ++++ L RI EG +G+V++AK +T EIVALK++ + + ++GFP +LREI L+ Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479 Query: 60 DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119 N V+ V + + ++ DL ++ ++P +VK+ + LL+GV H Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 539 Query: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVF-----------------SPD---GSRL 159 N I+HRDLK +NLL+S +G LK+ DFGLAR + +P+ G++ Sbjct: 540 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKE 599 Query: 160 YTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 219 Y+ V SVGCI GELL PLFPG ++I+Q+ V + LGTP+ ++WP +ELP K+ Sbjct: 600 YSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKM 659 Query: 220 SFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSE 278 +F E L + +S Q DL+ +FL Y P +RI+A L H+YF PLP PS Sbjct: 660 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM 719 Query: 279 LP 280 P Sbjct: 720 FP 721 >gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] Length = 360 Score = 180 bits (457), Expect = 1e-45 Identities = 107/296 (36%), Positives = 162/296 (54%), Gaps = 23/296 (7%) Query: 7 LGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQ 66 L RIGEG +GIV++A+ +T EIVALKKV + + +DG P +LREI L + + +V+ Sbjct: 42 LNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLR-HPNIVE 100 Query: 67 LKAVFP--HGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIV 124 LK V H L + DLA ++ + P ++AQVK + +L+G+ + H N I+ Sbjct: 101 LKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFII 160 Query: 125 HRDLKPANLLISASGQLKIADFGLARVF-----------------SPD---GSRLYTHQV 164 HRDLK +NLL++ G +K ADFGLAR + +P+ G+ T + Sbjct: 161 HRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSI 220 Query: 165 ATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQ 224 +VGCI+ ELL PL PG ++I Q+ ++++LGTP+ +WP ++LP + S ++Q Sbjct: 221 DMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQ 280 Query: 225 VPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELP 280 L+ P +S L LL +Y P +R A L YF PLP P +P Sbjct: 281 PYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMP 336 >gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] Length = 504 Score = 178 bits (452), Expect = 5e-45 Identities = 104/287 (36%), Positives = 152/287 (52%), Gaps = 22/287 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 ++ Y L ++GEG + VFK + T +VALK++ L E+G P A+RE+ L+ ++ Sbjct: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEH-EEGAPCTAIREVSLLKNLK- 228 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120 + +V L + L FE++ SDL + + H ++ VK ++ LL+G+A+CH Sbjct: 229 HANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHH 288 Query: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFS-----------------PD---GSRLY 160 I+HRDLKP NLLI+ G+LK+ADFGLAR S PD GS Y Sbjct: 289 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 348 Query: 161 THQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKIS 220 + + VGCI E+ G PLFPG E+L + R+LGTP + WP +T ++ S Sbjct: 349 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 408 Query: 221 FKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 267 F +P PL P + + LL LLY R++A AL H YF Sbjct: 409 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF 455 >gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] Length = 474 Score = 178 bits (452), Expect = 5e-45 Identities = 104/287 (36%), Positives = 152/287 (52%), Gaps = 22/287 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 ++ Y L ++GEG + VFK + T +VALK++ L E+G P A+RE+ L+ ++ Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEH-EEGAPCTAIREVSLLKNLK- 198 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120 + +V L + L FE++ SDL + + H ++ VK ++ LL+G+A+CH Sbjct: 199 HANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHH 258 Query: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFS-----------------PD---GSRLY 160 I+HRDLKP NLLI+ G+LK+ADFGLAR S PD GS Y Sbjct: 259 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 318 Query: 161 THQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKIS 220 + + VGCI E+ G PLFPG E+L + R+LGTP + WP +T ++ S Sbjct: 319 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 378 Query: 221 FKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 267 F +P PL P + + LL LLY R++A AL H YF Sbjct: 379 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF 425 >gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] Length = 474 Score = 178 bits (452), Expect = 5e-45 Identities = 104/287 (36%), Positives = 152/287 (52%), Gaps = 22/287 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 ++ Y L ++GEG + VFK + T +VALK++ L E+G P A+RE+ L+ ++ Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEH-EEGAPCTAIREVSLLKNLK- 198 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120 + +V L + L FE++ SDL + + H ++ VK ++ LL+G+A+CH Sbjct: 199 HANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHH 258 Query: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFS-----------------PD---GSRLY 160 I+HRDLKP NLLI+ G+LK+ADFGLAR S PD GS Y Sbjct: 259 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 318 Query: 161 THQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKIS 220 + + VGCI E+ G PLFPG E+L + R+LGTP + WP +T ++ S Sbjct: 319 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 378 Query: 221 FKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 267 F +P PL P + + LL LLY R++A AL H YF Sbjct: 379 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF 425 >gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] Length = 523 Score = 177 bits (449), Expect = 1e-44 Identities = 97/287 (33%), Positives = 159/287 (55%), Gaps = 22/287 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 M+ Y L ++GEG + V+K + T +VALK++ L E+G P A+RE+ L++++ Sbjct: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEH-EEGAPCTAIREVSLLKDLK- 246 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120 + +V L + L FE++ DL + + ++ VK +L +L+G+A+CH Sbjct: 247 HANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHR 306 Query: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFS-----------------PD---GSRLY 160 ++HRDLKP NLLI+ G+LK+ADFGLAR S PD GS Y Sbjct: 307 RKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEY 366 Query: 161 THQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKIS 220 + Q+ VGCI E+ +G PLFPG ++L + R+LGTP+ + WP ++ ++ + Sbjct: 367 STQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYN 426 Query: 221 FKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 267 F + P PL P + + ++L+ +FL Y +R++A +A+ H YF Sbjct: 427 FPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF 473 >gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] Length = 372 Score = 172 bits (437), Expect = 3e-43 Identities = 109/309 (35%), Positives = 163/309 (52%), Gaps = 37/309 (11%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 + +Y L +IG+G G VFKA+H +TG+ VALKKV + ++GFP ALREIK LQ ++ Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 Query: 61 NQYVVQLKA----VFPHG---GGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLK 113 V ++ P+ G L F+F DLA ++ + +++K +QMLL Sbjct: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 Query: 114 GVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFS-------------------- 153 G+ + H N I+HRD+K AN+LI+ G LK+ADFGLAR FS Sbjct: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 Query: 154 -PD---GSRLYTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPE 209 P+ G R Y + GCIM E+ SP+ G + QL + ++ G+ P+VWP Sbjct: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 Query: 210 LTELPDYNKISF----KEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQ 265 + Y K+ K +V L+ + D P ALDL+ + L+ P QRI + AL H Sbjct: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRD--PYALDLIDKLLVLDPAQRIDSDDALNHD 313 Query: 266 YFFTAPLPA 274 +F++ P+P+ Sbjct: 314 FFWSDPMPS 322 >gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] Length = 1030 Score = 167 bits (424), Expect = 9e-42 Identities = 105/294 (35%), Positives = 154/294 (52%), Gaps = 23/294 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 M+++ ILG +GEGA+G+V K +H ET EIVA+KK + LRE+K L+ ++ Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120 +V+LK F G L FE++ ++ E++ + +VKSY+ L+K + +CH Sbjct: 70 EN-IVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 128 Query: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR------------- 167 N+IVHRD+KP NLLIS + LK+ DFG AR S + YT VATR Sbjct: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPY 188 Query: 168 -------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKIS 220 SVGCI+GEL +G PLFPG+++I+QL + ++LG + P ++ + Sbjct: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248 Query: 221 FKE-QVPMPLE-EVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPL 272 F P LE L ++ LDL+ L P R + L H F T L Sbjct: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRL 302 >gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] Length = 1030 Score = 167 bits (424), Expect = 9e-42 Identities = 105/294 (35%), Positives = 154/294 (52%), Gaps = 23/294 (7%) Query: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60 M+++ ILG +GEGA+G+V K +H ET EIVA+KK + LRE+K L+ ++ Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69 Query: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120 +V+LK F G L FE++ ++ E++ + +VKSY+ L+K + +CH Sbjct: 70 EN-IVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 128 Query: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATR------------- 167 N+IVHRD+KP NLLIS + LK+ DFG AR S + YT VATR Sbjct: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPY 188 Query: 168 -------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKIS 220 SVGCI+GEL +G PLFPG+++I+QL + ++LG + P ++ + Sbjct: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248 Query: 221 FKE-QVPMPLE-EVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPL 272 F P LE L ++ LDL+ L P R + L H F T L Sbjct: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRL 302 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.141 0.427 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,001,335 Number of Sequences: 37866 Number of extensions: 755198 Number of successful extensions: 4796 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 734 Number of HSP's successfully gapped in prelim test: 76 Number of HSP's that attempted gapping in prelim test: 3040 Number of HSP's gapped (non-prelim): 1057 length of query: 325 length of database: 18,247,518 effective HSP length: 102 effective length of query: 223 effective length of database: 14,385,186 effective search space: 3207896478 effective search space used: 3207896478 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.