Search of human proteins with 122937382

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
         (1133 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]           2205   0.0  
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...   124   5e-28
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...   121   4e-27
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...   119   2e-26
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   118   4e-26
gi|148746195 trichohyalin [Homo sapiens]                              118   4e-26
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       110   6e-24
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       110   6e-24
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        110   6e-24
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        110   6e-24
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        110   6e-24
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        110   6e-24
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        110   6e-24
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        110   6e-24
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...   109   2e-23
gi|88196790 coiled-coil domain containing 88 [Homo sapiens]           108   3e-23
gi|21735548 centrosomal protein 2 [Homo sapiens]                      106   1e-22
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...   101   5e-21
gi|62243374 MAD1-like 1 protein [Homo sapiens]                        100   1e-20
gi|62243369 MAD1-like 1 protein [Homo sapiens]                        100   1e-20
gi|62243332 MAD1-like 1 protein [Homo sapiens]                        100   1e-20
gi|31982906 cingulin-like 1 [Homo sapiens]                             99   2e-20
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]    99   3e-20
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           98   4e-20
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           98   4e-20
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           98   4e-20
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    98   4e-20
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                97   7e-20
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         97   7e-20
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  97   7e-20

>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
          Length = 1133

 Score = 2205 bits (5713), Expect = 0.0
 Identities = 1133/1133 (100%), Positives = 1133/1133 (100%)

Query: 1    MAPKTKKGCKVTLPEKPVKLASHTRDTTGVSQMFPSSKARTKSLLGDDVFSTMAGLEEAD 60
            MAPKTKKGCKVTLPEKPVKLASHTRDTTGVSQMFPSSKARTKSLLGDDVFSTMAGLEEAD
Sbjct: 1    MAPKTKKGCKVTLPEKPVKLASHTRDTTGVSQMFPSSKARTKSLLGDDVFSTMAGLEEAD 60

Query: 61   AEVSGISEADPQALLQAMKDLDGMDADILGLKKSNSAPSKKAAKDPGKGELPNHPKPAGG 120
            AEVSGISEADPQALLQAMKDLDGMDADILGLKKSNSAPSKKAAKDPGKGELPNHPKPAGG
Sbjct: 61   AEVSGISEADPQALLQAMKDLDGMDADILGLKKSNSAPSKKAAKDPGKGELPNHPKPAGG 120

Query: 121  AIPTKKSLPSPSSSGHQNRRFSSEDLEDPLRGLLSYDEGGITKQPPVTQSKTASDKSPST 180
            AIPTKKSLPSPSSSGHQNRRFSSEDLEDPLRGLLSYDEGGITKQPPVTQSKTASDKSPST
Sbjct: 121  AIPTKKSLPSPSSSGHQNRRFSSEDLEDPLRGLLSYDEGGITKQPPVTQSKTASDKSPST 180

Query: 181  VRDQGPSIPLTPGDTPIRKKEELLFDDGDDIMATLGFGDSPKAEKRQIGDQEGPRPARST 240
            VRDQGPSIPLTPGDTPIRKKEELLFDDGDDIMATLGFGDSPKAEKRQIGDQEGPRPARST
Sbjct: 181  VRDQGPSIPLTPGDTPIRKKEELLFDDGDDIMATLGFGDSPKAEKRQIGDQEGPRPARST 240

Query: 241  LDELLGRGMATKLLARPGTGEHREFKLDKKYQRPQDSEDMWGDEDFTFGAYQPTVVSSEG 300
            LDELLGRGMATKLLARPGTGEHREFKLDKKYQRPQDSEDMWGDEDFTFGAYQPTVVSSEG
Sbjct: 241  LDELLGRGMATKLLARPGTGEHREFKLDKKYQRPQDSEDMWGDEDFTFGAYQPTVVSSEG 300

Query: 301  RQSRRQSVRFFADSGADPKGEPGSKQSPPMASSPIQPRKGGADWLGLKDEDLDLFPASPT 360
            RQSRRQSVRFFADSGADPKGEPGSKQSPPMASSPIQPRKGGADWLGLKDEDLDLFPASPT
Sbjct: 301  RQSRRQSVRFFADSGADPKGEPGSKQSPPMASSPIQPRKGGADWLGLKDEDLDLFPASPT 360

Query: 361  REAHRESSVPVTPSVPPPASQHSTPAGLPPSRAKPPTEGAGSPAKASQASKLRASKEEKE 420
            REAHRESSVPVTPSVPPPASQHSTPAGLPPSRAKPPTEGAGSPAKASQASKLRASKEEKE
Sbjct: 361  REAHRESSVPVTPSVPPPASQHSTPAGLPPSRAKPPTEGAGSPAKASQASKLRASKEEKE 420

Query: 421  DWLSHALSRKKSQGLAREQHAGTSEGLHLAGTAGHPPSGSQPLTSTQGLEHAAAGGSSGT 480
            DWLSHALSRKKSQGLAREQHAGTSEGLHLAGTAGHPPSGSQPLTSTQGLEHAAAGGSSGT
Sbjct: 421  DWLSHALSRKKSQGLAREQHAGTSEGLHLAGTAGHPPSGSQPLTSTQGLEHAAAGGSSGT 480

Query: 481  TARERPCVRPGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSV 540
            TARERPCVRPGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSV
Sbjct: 481  TARERPCVRPGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSV 540

Query: 541  PVQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLE 600
            PVQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLE
Sbjct: 541  PVQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLE 600

Query: 601  LERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQ 660
            LERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQ
Sbjct: 601  LERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQ 660

Query: 661  CQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKD 720
            CQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKD
Sbjct: 661  CQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKD 720

Query: 721  REVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLR 780
            REVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLR
Sbjct: 721  REVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLR 780

Query: 781  ALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALE 840
            ALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALE
Sbjct: 781  ALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALE 840

Query: 841  EQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERA 900
            EQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERA
Sbjct: 841  EQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERA 900

Query: 901  EREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEK 960
            EREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEK
Sbjct: 901  EREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEK 960

Query: 961  ERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLR 1020
            ERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLR
Sbjct: 961  ERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLR 1020

Query: 1021 KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSALMPPAPTTRWCS 1080
            KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSALMPPAPTTRWCS
Sbjct: 1021 KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSALMPPAPTTRWCS 1080

Query: 1081 QPPTGLDPSPLHLHARLALLRHMAEQDRDFLENEQFFLETLKKGSYNLTSHSA 1133
            QPPTGLDPSPLHLHARLALLRHMAEQDRDFLENEQFFLETLKKGSYNLTSHSA
Sbjct: 1081 QPPTGLDPSPLHLHARLALLRHMAEQDRDFLENEQFFLETLKKGSYNLTSHSA 1133


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sapiens]
          Length = 570

 Score =  124 bits (311), Expect = 5e-28
 Identities = 125/550 (22%), Positives = 255/550 (46%), Gaps = 66/550 (12%)

Query: 507  PTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLA 566
            P  +P  GTA  D   T+       T   T  S       PE   ++     E  ++ L 
Sbjct: 60   PQTNPSVGTAASD---TKKKKINNGTNPETTTSGGCHS--PEDEQKASHQHQEALRRELE 114

Query: 567  AQVQ----LQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLE 622
            AQVQ    L C   ELQ  L +SQ  + +LE + R L           G L+Q   A   
Sbjct: 115  AQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVAT 174

Query: 623  LIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAI 682
              + A R              E L +E + LS          E+ + E  A+ Q +L  +
Sbjct: 175  QKKKADRYI------------EELTKERDALSLELYRNTITDEELK-EKNAKLQEKLQLV 221

Query: 683  AQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLL-KDREVDA-ATSATSHTRSLNSII 740
              EK +    ++EL+R            +L+R KLL   +++ A A       +S+++ +
Sbjct: 222  ESEKSEIQLNVKELKR------------KLERAKLLLPQQQLQAEADHLGKELQSVSAKL 269

Query: 741  HQMEKFSSSLHELSSRVEASHLTTS---QERELGIRQRDEQLRALQERLGQQQRDM---E 794
                + +   + L+ + E          QERE  I++++E++R  +E++ +Q+  M   E
Sbjct: 270  QAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKE 329

Query: 795  EERSRQQEV-------IGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTA 847
            E+  RQ+E+       I ++E +++EQ ++ EQE  R   E+ K    ++  E++ K+  
Sbjct: 330  EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR--QEEEKIREQEKRQEQEAKMWR 387

Query: 848  QQMAM-ERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAER 906
            Q+  + E+ E  R +  +++EQ+    K GE+  ++  +  E   Q++  + + E+  E+
Sbjct: 388  QEEKIREQEEKIREQEEMMQEQEE---KMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQ 444

Query: 907  ALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINAT 966
              ++  Q E     + +++  ++ +  ++  +E ++  + A ++++ +++R ++E+I   
Sbjct: 445  EKKIREQEE----KIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQ 500

Query: 967  ALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHM 1026
              +++ + E++        E  +E E  + E ++   EQ+ ++Q   +Q+E++R+QE+ M
Sbjct: 501  EKKIREQEEKIREQE----EMMQEQEEKMWEQEEKMCEQEEKMQ---EQEEKMRRQEEKM 553

Query: 1027 HQEHLSLAQQ 1036
             ++ + L QQ
Sbjct: 554  REQEVRLRQQ 563


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
            sapiens]
          Length = 668

 Score =  121 bits (303), Expect = 4e-27
 Identities = 108/477 (22%), Positives = 229/477 (48%), Gaps = 39/477 (8%)

Query: 570  QLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHR 629
            +L+   A+LQ +L   ++  +E++  V++L+ +  + +LLL   QQQ QA+ + +    +
Sbjct: 218  ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP--QQQLQAEADHLGKELQ 275

Query: 630  SRIKVLETSYQQRE--ERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD 687
            S    L+   ++ E   RL ++ EE   R   + QE E+   E   + + +   I +E++
Sbjct: 276  SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI-REQE 334

Query: 688  QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFS 747
            ++M R  E+       MRR  E   ++ + ++  E +         R L   +H+ EK  
Sbjct: 335  EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLE-EMMWEKEEKIRELEEKMHEQEKIR 393

Query: 748  SSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM--EEERSRQQEVIG 805
                +     +       QE+E  + +++E++R  +E++ +Q++ M  +EE+  +QE I 
Sbjct: 394  EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 453

Query: 806  KMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALL 865
            + E R  ++    ++E+ R   EQ +    +  + EQ K+  Q+  + R E         
Sbjct: 454  EEEKRQEQEEMWRQEEKIR---EQEEIWRQKEKMHEQEKIRKQEEKVWRQE--------- 501

Query: 866  EEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAE--REAERALQVDTQREGTLISLAK 923
            E+      K  E+  ++  +  +   Q++  +E+ E  RE E  +Q   ++ G      +
Sbjct: 502  EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQ 561

Query: 924  EQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKV 983
            EQ +++ +  ++R +E+++  ++  + ++ +++  ++E+I            E E M + 
Sbjct: 562  EQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKI-----------REQEEMMQE 610

Query: 984  ASEKYEEGERALREAQQVQAEQQARL----QAVQQQQERLRKQEQHM--HQEHLSLA 1034
              EK  E E  + E ++   EQ+ ++    + + +Q+ RLR+QE+ M  HQEHL  A
Sbjct: 611  QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 667



 Score =  113 bits (282), Expect = 1e-24
 Identities = 131/621 (21%), Positives = 263/621 (42%), Gaps = 100/621 (16%)

Query: 507  PTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLA 566
            P  +P  GTA  D   T+       T   T  S       PE   ++     E  ++ L 
Sbjct: 72   PQTNPSVGTAASD---TKKKKINNGTNPETTTSGGCHS--PEDEQKASHQHQEALRRELE 126

Query: 567  AQVQ----LQCSPAELQAELLHSQARLAELEAQVRKL------------ELERA------ 604
            AQV     L C   ELQ  L +SQ  + +LE + R L            ELE+A      
Sbjct: 127  AQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVAT 186

Query: 605  -------------------QHELLLGSLQQQH--------QADLELIES----------- 626
                                 EL   ++  +         Q  L+L+ES           
Sbjct: 187  QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 246

Query: 627  ----AHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAI 682
                  R+++ + +   Q   + L +E + +SA+  +Q +E E     L  Q + ++   
Sbjct: 247  LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN-RLNQQQEEKMWR- 304

Query: 683  AQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQ 742
             +EK QE E   + Q   I    R+ EE+++  +    R+ +         R    ++ +
Sbjct: 305  QEEKIQEWEEKIQEQEEKI----REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360

Query: 743  MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQE 802
             E+    L E+             E+E  IR+ +E++   ++   Q+++  EEE+ R+QE
Sbjct: 361  KEEKMRRLEEM-----------MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 409

Query: 803  VIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKS 862
               + EA++  Q   + ++  ++  ++ K    +  + EQ K+  ++   E+ E+ R + 
Sbjct: 410  KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 469

Query: 863  ALLEE-----QKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGT 917
             + E+     QK  M +  + R++    W +        ++  E+E +   Q +  RE  
Sbjct: 470  KIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQE 529

Query: 918  LISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEV 977
                 +EQ E      E+  E+++   E+    QE++++R ++E+I     +++ + E++
Sbjct: 530  --EKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI 587

Query: 978  -ESMSKV--ASEKYEEGERALREAQQVQAEQQARL----QAVQQQQERLRKQEQHMHQEH 1030
             E   K+    EK  E E  ++E ++   EQ+ ++    + +Q+Q+E++R+QE+ M ++ 
Sbjct: 588  REQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 647

Query: 1031 LSLAQQRLQLDRARQDLPSSL 1051
            + L QQ  ++   ++ L +++
Sbjct: 648  VRLRQQEEKMQEHQEHLEAAI 668


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
            protein 6 [Homo sapiens]
          Length = 724

 Score =  119 bits (297), Expect = 2e-26
 Identities = 101/484 (20%), Positives = 235/484 (48%), Gaps = 40/484 (8%)

Query: 570  QLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHR 629
            +L+   A+LQ +L   ++  +E++  V++L+ +  + +LLL   QQQ QA+ + +    +
Sbjct: 279  ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP--QQQLQAEADHLGKELQ 336

Query: 630  SRIKVLETSYQQRE--ERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD 687
            S    L+   ++ E   RL ++ EE   R   + QE E+   E   + + +   I +E++
Sbjct: 337  SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI-REQE 395

Query: 688  QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFS 747
            ++M R  E+       MRR  E   ++ + ++ R+ +         R L   +H+ EK  
Sbjct: 396  EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR-RQEEMMWEKEEKIRELEEKMHEQEKIR 454

Query: 748  SSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKM 807
                +     +       QE+E  + +++E++R  +E++    R+ EE+  RQ+E I + 
Sbjct: 455  EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI----REQEEKMWRQEEKIHEQ 510

Query: 808  EARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEE 867
            E    E+ R  ++E WR   ++ K    +    ++ K+  Q+   E+   +  K    EE
Sbjct: 511  EKIREEEKRQEQEEMWR---QEEKIREQEEIWRQKEKIHEQE---EKIRKQEEKMWRQEE 564

Query: 868  QKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAE 927
                  K  ++  ++  +  +   Q++  +E+ E+  E+  ++  Q E     + +EQ E
Sbjct: 565  ------KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEE-----MTQEQEE 613

Query: 928  LKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEK 987
                  ++  +E+++  +   ++++ +++R ++E+I     +++ + E++        E 
Sbjct: 614  ------KMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ----EEM 663

Query: 988  YEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDL 1047
             +E E  + E ++   EQ+ ++   Q+Q+E++R+QE+ M ++ + L QQ  ++   ++ L
Sbjct: 664  MQEQEEKMWEQEEKMCEQEEKM---QEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720

Query: 1048 PSSL 1051
             +++
Sbjct: 721  EAAI 724



 Score =  107 bits (268), Expect = 5e-23
 Identities = 133/570 (23%), Positives = 247/570 (43%), Gaps = 60/570 (10%)

Query: 507  PTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLA 566
            P  +P  GTA  D   T+       T   T  S       PE   ++     E  ++ L 
Sbjct: 133  PQTNPSVGTAASD---TKKKKINNGTNPETTTSGGCHS--PEDEQKASHQHQEALRRELE 187

Query: 567  AQVQ----LQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLE 622
            AQV     L C   ELQ  L +SQ  + +LE + R L           G L+Q       
Sbjct: 188  AQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQA------ 241

Query: 623  LIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAI 682
                   S +   +    +  E L +E + LS          E+ + E  A+ Q +L  +
Sbjct: 242  ------LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK-EKNAKLQEKLQLV 294

Query: 683  AQEKDQ----EMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSL-N 737
              EK +      E  R+L+RA +L  ++  + +   L   + + V A   A      L N
Sbjct: 295  ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG-KELQSVSAKLQAQVEENELWN 353

Query: 738  SIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM---E 794
             +  Q E+      E     E       QE+E  IR+++E++R  +E++ +Q+  M   E
Sbjct: 354  RLNQQQEEKMWRQEEKIQEWEEK----IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 409

Query: 795  EERSRQQEVIGKMEARLNEQSRLLEQERWRVTA------EQSKAESMQRALEEQRKVTAQ 848
            E+  RQ+E++ + E ++  Q  ++ ++  ++        EQ K    +   +E+ K+  Q
Sbjct: 410  EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 469

Query: 849  QMAMER-AELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERA 907
            +   E+ A++ R +  + E+++    K  E+  ++  +  +   Q+K+ +E   +E E  
Sbjct: 470  EKRQEQEAKMWRQEEKIREQEE----KIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEM 525

Query: 908  -LQVDTQREGTLISLAKE---QAELKIRASE---LRAEEKQLAAERAALEQERQELRLEK 960
              Q +  RE   I   KE   + E KIR  E    R EEK    E    EQE +  R ++
Sbjct: 526  WRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWR-QE 584

Query: 961  ERINATALRVKLRAEEV---ESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQE 1017
            E+I     +++ + E++   E M++   EK  E E  + E ++   EQ+ ++   ++Q+E
Sbjct: 585  EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKM---RRQEE 641

Query: 1018 RLRKQEQHMHQEHLSLAQQRLQLDRARQDL 1047
            ++R+QE+ + ++   + +Q   +    + +
Sbjct: 642  KIREQEKKIREQEEKIREQEEMMQEQEEKM 671


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
            sapiens]
          Length = 750

 Score =  118 bits (295), Expect = 4e-26
 Identities = 107/528 (20%), Positives = 247/528 (46%), Gaps = 63/528 (11%)

Query: 570  QLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD---LELIES 626
            +L+   A+LQ +L   ++  +E++  V++L+ +  + +LLL   Q Q +AD    EL   
Sbjct: 218  ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 277

Query: 627  AHRSRIKVLETSY-----QQREERLRRENEELSARYLSQCQEAEQARAELTA------QH 675
            + + + +V E        QQ+EE++ R+ E++   +  + QE E+   E         + 
Sbjct: 278  SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ-EWEEKIQEQEEKIREQEEKIREQEEK 336

Query: 676  QRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRS 735
             RR   +  EK+++M R  E+       MRR  E   ++ + ++ R+ +         R 
Sbjct: 337  MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR-RQEEMMWEKEEKIRE 395

Query: 736  LNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM-- 793
            L   +H+ EK      +     +       QE+E  + +++E++R  +E++ +Q++ M  
Sbjct: 396  LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR 455

Query: 794  ------------EEERSRQQEVIGKMEARLNEQSRL------LEQERWRVTAEQSKAESM 835
                        EEE+ ++QE + + E +++EQ  +      + ++  ++  ++ K    
Sbjct: 456  QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ 515

Query: 836  QRALEEQR-KVTAQQMAMERAE---LERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSA 891
            +  + EQ  K+  Q+  M R E    E+ +    EE+     K  EE +R   E   +  
Sbjct: 516  EEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQ 575

Query: 892  QQKL--SKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAAL 949
            ++K+   +E+  R+ E+  + + +R+     + K++ +++ +  +++ +E+++  +   +
Sbjct: 576  EEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKI 635

Query: 950  EQERQELRLEKERINA-----------------TALRVKLRAEEVESMSKVASEKYEEGE 992
             ++ +  + ++E++                   T  R + +  E E   +   EK  E E
Sbjct: 636  REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQE 695

Query: 993  RALREAQQVQAEQQARL----QAVQQQQERLRKQEQHMHQEHLSLAQQ 1036
              ++E ++   EQ+ ++    + +Q+Q+E++R+QE+ M ++ + L QQ
Sbjct: 696  EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 743



 Score =  101 bits (251), Expect = 5e-21
 Identities = 128/547 (23%), Positives = 231/547 (42%), Gaps = 58/547 (10%)

Query: 507  PTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLA 566
            P  +P  GTA  D   T+       T   T  S       PE   ++     E  ++ L 
Sbjct: 72   PQTNPSVGTAASD---TKKKKINNGTNPETTTSGGCHS--PEDEQKASHQHQEALRRELE 126

Query: 567  AQVQ----LQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLE 622
            AQV     L C   ELQ  L +SQ  + +LE + R L           G L+Q       
Sbjct: 127  AQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQA------ 180

Query: 623  LIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAI 682
                   S +   +    +  E L +E + LS          E+ + E  A+ Q +L  +
Sbjct: 181  ------LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK-EKNAKLQEKLQLV 233

Query: 683  AQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQ 742
              EK +    ++EL+R            +L+R KLL  ++      A    + L S+  +
Sbjct: 234  ESEKSEIQLNVKELKR------------KLERAKLLLPQQ-QLQAEADHLGKELQSVSAK 280

Query: 743  MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQ---RDMEEERSR 799
            ++      +EL +R+          +E  I++ +E+++  +E++ +Q+   R+ EE+  R
Sbjct: 281  LQA-QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339

Query: 800  QQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELER 859
            Q+E++ + E ++  Q    E+  W    +  + E M    EE+ +   ++M  E+ E  R
Sbjct: 340  QEEMMWEKEEKMRRQ----EEMMWEKEEKMRRQEEMMWEKEEKMR-RQEEMMWEKEEKIR 394

Query: 860  AKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLI 919
                 + EQ+ +  +  EE+R+   E  +   Q+K    R E+EA+   Q +  RE    
Sbjct: 395  ELEEKMHEQEKIREQ--EEKRQ---EEEKIREQEK----RQEQEAKMWRQEEKIREQE-- 443

Query: 920  SLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVES 979
               +EQ +   R  E   E++++  E    EQE    + EK        R K +  E E 
Sbjct: 444  EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503

Query: 980  MSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQ 1039
              +   EK    E  +RE ++   EQ+ ++    +Q+E++R+QE+   +E     Q+++ 
Sbjct: 504  KIRKQEEKVWRQEEKIREQEEKIREQEEKM---WRQEEKIREQEEMWREEEKMHEQEKIW 560

Query: 1040 LDRARQD 1046
             +  RQ+
Sbjct: 561  EEEKRQE 567


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  118 bits (295), Expect = 4e-26
 Identities = 132/546 (24%), Positives = 245/546 (44%), Gaps = 59/546 (10%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQH- 617
            E +K+    +  L+    +LQ E    Q  L E E Q+RKLE +  + E      QQQ  
Sbjct: 241  EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300

Query: 618  ----------QADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQA 667
                      + +    +   R + +  E   ++RE++LRRE EE   + L + QE E+ 
Sbjct: 301  RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR 360

Query: 668  RAELTAQHQRRLAAIAQEKDQEMERLRELQRASIL----------DMRRDH----EEQLQ 713
              +L  + +         ++Q++ R ++L+R   L           +RR+     E+QL+
Sbjct: 361  EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 420

Query: 714  R-LKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSL--------HELSSRVEASHLTT 764
            R  +L +++E +         R    +  + E+    L        HE   R +      
Sbjct: 421  REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ 480

Query: 765  SQER-ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERW 823
             +ER E  ++  +E+ R  QER  QQ R  +EER R+Q  + + E     Q RL  +++ 
Sbjct: 481  EEERRERWLKLEEEERREQQERREQQLRREQEER-REQR-LKRQEEEERLQQRLRSEQQL 538

Query: 824  RVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALL--EEQKSVMLKCGEERR- 880
            R   E+ + + ++R  E++ +   ++  ++R + ER    L   EE++   LK  +E R 
Sbjct: 539  RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL 598

Query: 881  --RLAAEWAEFSAQQKLSKERAERE------AERALQVDTQREGTLISLAKEQAELKIRA 932
              RL  E  E   Q++  ++R +RE       ++ L+ + Q E     L +EQ E + + 
Sbjct: 599  EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658

Query: 933  SELRAEEKQLAAE-RAALEQERQELRLEKERINATALRVK---------LRAEEVESMSK 982
             +   EE++L    +   E+ER+E  L +E       R+K         L +E     SK
Sbjct: 659  LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718

Query: 983  VASE-KYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLD 1041
            V S  + +EG+R  +E ++ +  +++ LQ  ++++   ++QE+   ++     Q   + +
Sbjct: 719  VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778

Query: 1042 RARQDL 1047
            R RQ L
Sbjct: 779  RGRQRL 784



 Score =  110 bits (276), Expect = 6e-24
 Identities = 127/528 (24%), Positives = 231/528 (43%), Gaps = 49/528 (9%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGS----LQ 614
            E +KQ L    + +     L+ E    + +    E Q+R+ + ER +  L        LQ
Sbjct: 470  ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529

Query: 615  QQHQADLELIESAHRSRIKVLETS------YQQREERLRRENEELSARYLSQCQEAEQAR 668
            Q+ +++ +L       R ++L+         ++RE+RL+RE EE   + L + +E  Q R
Sbjct: 530  QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589

Query: 669  AELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATS 728
              L  + + RL    + K +E+ERL + +R     ++R+  E+ +R +LLK  E +    
Sbjct: 590  --LKREQEERLEQ--RLKREEVERLEQEERRE-QRLKREEPEEERRQQLLKSEEQEERRQ 644

Query: 729  ATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQ 788
                 R       Q  K       L  R++  H    +E+EL   ++++    ++ R+ +
Sbjct: 645  QQLR-REQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703

Query: 789  QQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAE-------QSKAESMQRALEE 841
             Q  +E E   +Q  +     +   Q R  EQE  R   E       + +A   Q+  E+
Sbjct: 704  WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763

Query: 842  QRKVTAQQMAMERAELERAKSAL---LEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKE 898
            +R  T Q  A E++E  R + +    L EQ+   L+  E ++R          +Q+   E
Sbjct: 764  RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR----------EQRFLPE 813

Query: 899  RAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAE---RAALEQERQE 955
              E+E  R  + + ++E   +   +EQ + + RA +L+ EE  L  +   R + EQ R +
Sbjct: 814  EEEKEQRRRQRREREKELQFLE-EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872

Query: 956  -----LRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALRE--AQQVQAEQQAR 1008
                 L  E++R   T        E++    ++  E+ EE +R  RE   +Q Q  Q   
Sbjct: 873  KWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE 932

Query: 1009 LQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFP 1056
             + +QQ++E+L ++E+   +      Q R   D+  Q     L+G  P
Sbjct: 933  EEQLQQEEEQLLREEREKRRRQERERQYR--KDKKLQQKEEQLLGEEP 978



 Score =  101 bits (251), Expect = 5e-21
 Identities = 136/551 (24%), Positives = 240/551 (43%), Gaps = 59/551 (10%)

Query: 547  PESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQV-RKLELERAQ 605
            PE   R  L  +E Q++    Q QL+    E + + L  +     LE ++ R+ E ER +
Sbjct: 625  PEEERRQQLLKSEEQEE--RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682

Query: 606  HELLLGSLQQQHQA--------DLELIESAHRSRIKVLETSYQQREERLRRENEELSARY 657
             EL     +Q  +           +L   A   + KV     +Q  +R R+E EE   R 
Sbjct: 683  QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742

Query: 658  LS--QCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRL 715
             S  Q QE E+A  +   + QRR      + +++ ER R  QR S     R+  E+  R 
Sbjct: 743  ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR--QRLSARPPLREQRERQLRA 800

Query: 716  KLLKDRE---VDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGI 772
            +  + RE   +          R       +++ F     +L  R  A  L   QE E G+
Sbjct: 801  EERQQREQRFLPEEEEKEQRRRQRREREKELQ-FLEEEEQLQRRERAQQL---QEEEDGL 856

Query: 773  RQRDEQLRALQERLGQQQR-DMEEERSRQ----------QEVIGKMEARLNEQSRLLEQE 821
            ++  E+ R+ ++R  Q+ R  +EEER R+          QE + K +  L E+   L++E
Sbjct: 857  QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916

Query: 822  ----RWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERA--KSALLEEQKSVMLKC 875
                R R   E+   E  Q   EE++ +  ++    R E ER   K   L++++  +L  
Sbjct: 917  EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGE 976

Query: 876  GEERRRLAAEWAEFSAQQKLS-------KERAER----EAERALQVD---TQREGTLISL 921
              E+RR      ++  +++L        +E  E+    E ER  +      Q E  L+  
Sbjct: 977  EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036

Query: 922  AKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESM- 980
             +E+  L+ R  + R EE++L  E   L  E +E R  +E         +L+ EE + + 
Sbjct: 1037 EREKRRLQERERQYR-EEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095

Query: 981  SKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQL 1040
             +    + +E ER  RE +++Q E++  L+  ++++ R   + Q+  +E +   +++L  
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155

Query: 1041 D----RARQDL 1047
            +    R RQ+L
Sbjct: 1156 EEPEKRRRQEL 1166



 Score =  100 bits (249), Expect = 8e-21
 Identities = 130/562 (23%), Positives = 251/562 (44%), Gaps = 84/562 (14%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHEL---LLGSLQQ 615
            E  +Q L ++ QL+    E + +LL  +     LE + R+  L+R Q E    LL   ++
Sbjct: 526  ERLQQRLRSEQQLRREQEERREQLLKREEE-KRLEQERREQRLKREQEERRDQLLKREEE 584

Query: 616  QHQADLE------LIESAHRSRIKVLETSYQQREERLRREN-EELSARYLSQCQEAEQAR 668
            + Q  L+      L +   R  ++ LE   ++RE+RL+RE  EE   + L + +E E+ R
Sbjct: 585  RRQQRLKREQEERLEQRLKREEVERLEQE-ERREQRLKREEPEEERRQQLLKSEEQEERR 643

Query: 669  AELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATS 728
             +   + Q+       ++++E ERL +        ++R+HEE+ +  +L ++ +  A   
Sbjct: 644  QQQLRREQQERREQRLKREEEEERLEQR-------LKREHEEERREQELAEEEQEQARER 696

Query: 729  ATSHTRSLN-SIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLG 787
              S        +  + +   S ++    + E       QE+E   R+R+ +L+  +E   
Sbjct: 697  IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR--RRQEQEEKRRRRESELQWQEEERA 754

Query: 788  QQQRDMEEERS------RQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEE 841
             +Q+  EE+R       + +E   +   RL+ +  L EQ   ++ AE+ +    +   EE
Sbjct: 755  HRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEE 814

Query: 842  QRKVTAQQMAMERA----------ELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSA 891
            + K   ++   ER           +L+R + A   +++   L+  +ERRR   +  +   
Sbjct: 815  EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874

Query: 892  QQKLSKERAERE----AERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERA 947
            + +L +ER  R     A+ ALQ   ++E  L+   +E+ + + R    R E+++   E  
Sbjct: 875  RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934

Query: 948  ALEQERQEL---------RLEKERINATALRV-------------KLRAEEVESMSKVAS 985
             L+QE ++L         R E+ER      ++             K R +E E   +   
Sbjct: 935  QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994

Query: 986  EKYEEGERALREAQQVQAEQQARLQ-----AVQQQQE----------RLRKQE-QHMHQE 1029
            E  +E E+ LRE ++ +  Q+   Q      +QQ++E          RL+++E Q+  +E
Sbjct: 995  ELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE 1054

Query: 1030 HLSLAQQRL----QLDRARQDL 1047
             L   +++L    +  R RQ+L
Sbjct: 1055 ELQQEEEQLLGEERETRRRQEL 1076



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 129/540 (23%), Positives = 235/540 (43%), Gaps = 72/540 (13%)

Query: 559  EYQKQLLAAQVQLQCSPAELQA------------ELLHSQAR---LAELEAQVRKLELER 603
            E +++ L  + QL+C   E Q             + L  Q R     E E QVR+ E ER
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER 1446

Query: 604  AQHELLLGSLQQQHQA---DLELIESAHRSRIKVLETS--YQQREERLRRENEELSAR-- 656
               E      Q++H+    + +L++     ++   E    + + E++LRR+  +   R  
Sbjct: 1447 KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ 1506

Query: 657  -YLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRL 715
               SQ  E +    E     Q+R     QE+ Q   + R  QR    D +   EEQL++ 
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566

Query: 716  KLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR 775
            +  +++++               +  Q ++      E   R +       QER+   R+ 
Sbjct: 1567 R--EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE- 1623

Query: 776  DEQLRALQER----LGQQQRD---MEEE-----RSRQQEVIGKMEARLNEQSRLLE---- 819
            DEQL  LQER    L +Q+RD   +EEE     + R+Q++    + +  E+ +LL+    
Sbjct: 1624 DEQL--LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681

Query: 820  -----QERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLK 874
                 QER R   E+   E   R  E +RK   ++  + R ELER       E++ +  +
Sbjct: 1682 QQLRRQERDRKFREE---EQQLRRQERERKFLQEEQQLRRQELERK----FREEEQLRQE 1734

Query: 875  CGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASE 934
              +E+ R    + +   +++L  ER E++  R  +    RE   +   +E+ +L+ + S+
Sbjct: 1735 TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESD 1794

Query: 935  LR-AEEKQLAAERAALEQERQE----LRLEKERINATALRVKLRAEEVESMSKVASEKYE 989
             +  EE+QL  ER   +   Q+     R E+E++       +LR E        A E++ 
Sbjct: 1795 RKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR--AEEQFA 1852

Query: 990  EGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPS 1049
              E++ RE Q++  E++         Q+R +++E+ + +EH+   Q+  Q  R   ++ S
Sbjct: 1853 TQEKSRREEQELWQEEE---------QKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 117/512 (22%), Positives = 232/512 (45%), Gaps = 66/512 (12%)

Query: 585  SQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLE----TSYQ 640
            + AR +++ ++ RK E +R + E      +++ +   +  E AHR + +  +    T   
Sbjct: 712  ADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771

Query: 641  QREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRA- 699
            Q EE+  R  + LSAR   + Q   Q RAE   Q ++R     +EK+Q   + RE ++  
Sbjct: 772  QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831

Query: 700  SILD-----MRRDHEEQLQRLK--LLKDRE----------------VDAATSATSHTRSL 736
              L+      RR+  +QLQ  +  L +D+E                ++       HT   
Sbjct: 832  QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA 891

Query: 737  NSIIH-QMEKFSSSLHELSSRV--EASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM 793
               +  Q+ K    L E    +  E       QE+E   R+ +EQL+  +E+L +++R+ 
Sbjct: 892  KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE-EEQLQQEEEQLLREEREK 950

Query: 794  EEERSRQQEVIGKMEARLNEQSRLLEQ--ERWRVTAEQSKAESMQRALEEQRKVTAQQMA 851
               + R+++     + +  E+  L E+  +R R   E+   E  +   EE++ +  ++  
Sbjct: 951  RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010

Query: 852  MERAELERA--KSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKE----------- 898
              R E ER   K   L++++  +L+   E+RRL     ++  +++L +E           
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070

Query: 899  RAEREAERALQVDTQREGTLISLAKEQAELKIRAS---------ELRAEEKQLAAE---- 945
            R  +E ER  + + + +     L +E+ E + R           EL+ EE+QL  E    
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130

Query: 946  --RAALEQ---ERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQ 1000
              R  LE+   E +E++ E+E++       K R +E+E   +   E  +E E+ LRE Q+
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPE-KRRRQELERQYREEEELQQEEEQLLREEQE 1189

Query: 1001 VQAEQQARLQAVQQQQERLRKQEQHMHQEHLS 1032
             + +++ R    +++ +R ++++++  ++  S
Sbjct: 1190 KRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 136/559 (24%), Positives = 239/559 (42%), Gaps = 69/559 (12%)

Query: 533  QKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAEL 592
            +K  E     + LL E   +  L   E Q +    + +LQ    +L  E   ++ R  EL
Sbjct: 1021 RKKDELQQEEEQLLREEREKRRLQERERQYR---EEEELQQEEEQLLGEERETRRR-QEL 1076

Query: 593  EAQVRKLE-LERAQHELLLGSLQQQHQADLE----------------LIESAHRSRIKVL 635
            E Q RK E L++ + +LL    +++ + + E                L E   + R + L
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136

Query: 636  ETSY------QQREERLRREN------EELSARYLSQCQEAEQARAELTAQHQRRLAAIA 683
            E  Y      QQ EE+L RE       +EL  +Y  + +E +Q   +L  + Q +     
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE-EELQQEEEQLLREEQEKRR--- 1192

Query: 684  QEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAAT--SATSHTRSLNSIIH 741
            QE++++     ELQR       RD E+Q   LK   + E + A   +        N    
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRD-EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251

Query: 742  QMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQ 801
            Q+E   S L +  S+ +  HL   Q+     R R+++ R  Q+R      + + ER  Q+
Sbjct: 1252 QLE--DSQLRDRQSQQDLQHLLGEQQE----RDREQERRRWQQRDRHFPEEEQLEREEQK 1305

Query: 802  EVIGKMEARLNEQSRLLEQERWRVTAEQS---KAESMQRALEEQRKVTAQQMAMER---- 854
            E   + + +  E+ +LL +ER      Q    K    ++ L+E+ +   ++   +R    
Sbjct: 1306 EA-KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE 1364

Query: 855  ---AELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQ---QKLSKERAEREAERAL 908
                  E+ +  L EEQ+   L+  E  R+   E  +   Q   Q+L ++R  +  E   
Sbjct: 1365 EELRHQEQGRKFLEEEQR---LRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ 1421

Query: 909  QVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKE--RINAT 966
            Q+  Q         ++Q   + R  +   EE+QL  ER    +E ++L  E+E  +++  
Sbjct: 1422 QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ 1481

Query: 967  ALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHM 1026
                K   EE +   +    K+ E E   +E ++   E++ +L   Q+Q++ L++++Q  
Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541

Query: 1027 HQEHLSLAQQRLQLDRARQ 1045
             QE     QQR Q DR R+
Sbjct: 1542 RQER---GQQRRQ-DRDRK 1556



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 115/507 (22%), Positives = 222/507 (43%), Gaps = 29/507 (5%)

Query: 558  TEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQ-VRKLELERAQHELLLGSLQQQ 616
            ++ +KQLL  + + +    E   +    +  L E E Q +R+ E +R   E     L+ Q
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE---EELRHQ 1370

Query: 617  HQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQ 676
             Q   + +E   R R +  E  + + E++LR +  E   R   + ++  +   +L+ Q +
Sbjct: 1371 EQGR-KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ-DRDRKFREEEQQLSRQER 1428

Query: 677  RRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSL 736
             R     +++ +  ER R+         +  H +  +  +LL++RE           + L
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488

Query: 737  NS---IIHQMEKFSSSLHELSSR------VEASHLTTSQERELGIRQRDEQLRALQERLG 787
                 +  Q         EL S+      +E       Q+R+    Q ++QLR  QER G
Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR-QER-G 1546

Query: 788  QQQRDMEEERSRQQEVIGK----MEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQR 843
            QQ+R   + + R++E + +     +    E+ R    E  +V  ++ + + M+   + +R
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606

Query: 844  KVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAERE 903
            +   QQ+  ER    R    LL+E++   L   E  R+   E  +   Q++  + R +R+
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRD 1666

Query: 904  AERALQVDTQREGTLISLAKEQAELKIRASE--LRAEEKQLAAERAALEQERQELRLEKE 961
             +   +    +EG    L +++ + K R  E  LR +E+    ER  L++E+Q  R E E
Sbjct: 1667 RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQER----ERKFLQEEQQLRRQELE 1722

Query: 962  RI--NATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERL 1019
            R       LR +   E++    +      EE  R  RE QQ++ +++ R    ++Q  + 
Sbjct: 1723 RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782

Query: 1020 RKQEQHMHQEHLSLAQQRLQLDRARQD 1046
            R+++Q   QE     ++  QL + R++
Sbjct: 1783 REEQQLRSQESDRKFREEEQLRQEREE 1809



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 108/414 (26%), Positives = 184/414 (44%), Gaps = 57/414 (13%)

Query: 624  IESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIA 683
            ++   R+R    E+  Q R +   +   E   R L +  E  Q R +   + +R LA   
Sbjct: 95   LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEE--EPGQRRRQKRQEQERELAE-G 151

Query: 684  QEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQM 743
            +E+ ++ ERL +  R      RRD E   QR +  +  E  A        +      H+ 
Sbjct: 152  EEQSEKQERLEQRDR-----QRRDEELWRQRQEWQEREERRAEEEQLQSCKG-----HET 201

Query: 744  EKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQE- 802
            E+F     E   R E   L     R  G  ++ +Q R  Q+R+ Q++   EE+  R++E 
Sbjct: 202  EEFPDE--EQLRRRELLEL-----RRKGREEKQQQRRERQDRVFQEE---EEKEWRKRET 251

Query: 803  VIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKS 862
            V+ K E +L E+             E  +   +Q   E+ RK+  Q++  ER E E+ + 
Sbjct: 252  VLRKEEEKLQEE-------------EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298

Query: 863  ALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLA 922
             L  EQ+ +  K  EERR    E  E   +++  +ER E++  R      Q E     L 
Sbjct: 299  RLRREQQ-LRRKQEEERREQQEERREQQERREQQEERREQQLRR-----EQEERREQQLR 352

Query: 923  KEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSK 982
            +EQ E + R  +LR E+++        E+  Q+LR E++      LR   R +++    +
Sbjct: 353  REQEEER-REQQLRREQEE--------ERREQQLRREQQLRREQQLR---REQQLRREQQ 400

Query: 983  VASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQ 1036
            +  E+    E+ LR  QQ++ EQQ R +  Q+++   +K EQ   ++ L   Q+
Sbjct: 401  LRREQQLRREQQLRREQQLRREQQLRRE--QEEERHEQKHEQERREQRLKREQE 452



 Score = 90.5 bits (223), Expect = 8e-18
 Identities = 129/539 (23%), Positives = 231/539 (42%), Gaps = 58/539 (10%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGS-------- 612
            Q+QL   Q  LQ    ELQ E    + R  E E Q R+ E  + + E LL          
Sbjct: 896  QEQLRKEQQLLQEEEEELQREEREKRRR-QEQERQYREEEQLQQEEEQLLREEREKRRRQ 954

Query: 613  -LQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAEL 671
              ++Q++ D +L +   +   +  E   +Q  E+  RE EEL        +E  + R   
Sbjct: 955  ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014

Query: 672  TAQHQ-RRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLK---LLKDREVDAAT 727
              + Q R+   + QE++Q +   RE +R    + +   EE+LQ+ +   L ++RE     
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ 1074

Query: 728  SATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLG 787
                  R    +  + E+      E   R E       +E    ++Q +EQL   +ER  
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE---LQQEEEQLLR-EEREK 1130

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQS---RLLEQER-WRVTAE-QSKAESMQRALEEQ 842
            ++++++E +   ++EV  + E  L E+    R  E ER +R   E Q + E + R  +E+
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK 1190

Query: 843  RKVTAQQMAMERAELERAKSALL---EEQKSVM----------------LKC----GEER 879
            R+   ++   E  EL+R K       E+Q+S +                + C     E+ 
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250

Query: 880  RRLA-AEWAEFSAQQKLSK---ERAEREAERALQVDTQREGTLIS---LAKEQAELKIRA 932
            R+L  ++  +  +QQ L     E+ ER+ E+  +   QR+        L +E+ +   R 
Sbjct: 1251 RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR 1310

Query: 933  SELRAEEKQLAAERAALEQERQE----LRLEKERINATALRVKLRAEEVESMSKVASEKY 988
                 EEKQL  E    ++ RQE     R E++ +     +   R E      +      
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370

Query: 989  EEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEH-LSLAQQRLQLDRARQD 1046
            E+G + L E Q+++ +++ R    ++QQ R +++EQ + Q+      ++  QL R  +D
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERD 1429



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 116/478 (24%), Positives = 208/478 (43%), Gaps = 68/478 (14%)

Query: 588  RLAELEAQVRKLELERAQHELLLGS---------LQQQHQADLELIESAHRSRIKVLETS 638
            RL E E Q R+ E  + + E LLG          L++Q++ + EL +   +   +  E  
Sbjct: 1042 RLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101

Query: 639  YQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQ-RRLAAIAQEKDQEMERLRELQ 697
             +Q  ER  RE EEL        +E  + R     + Q R    + QE++Q +    E +
Sbjct: 1102 RRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161

Query: 698  RASILDMRRDHEEQLQRLK--LLKDREVDAATSATSHTRSLNSIIHQMEKF----SSSLH 751
            R   L+ +   EE+LQ+ +  LL++ +           R    +  Q  K          
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221

Query: 752  ELSSRVEASHLTTSQERELGIRQRD-EQLRALQERLGQQQRDMEEERSRQQEVIGKMEAR 810
            +L  + E       ++ ++  + R+ EQ R L++    Q RD + ++  Q  ++G+ + R
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED---SQLRDRQSQQDLQH-LLGEQQER 1277

Query: 811  LNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKS 870
              EQ R   Q+R R   E+ + E      EEQ++      A  R    + +  LL E++ 
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLER-----EEQKE------AKRRDRKSQEEKQLLREER- 1325

Query: 871  VMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKI 930
                  EE+RR      +F  +++L +ER E+                  L +++ + K 
Sbjct: 1326 ------EEKRRRQETDRKFREEEQLLQEREEQP-----------------LRRQERDRKF 1362

Query: 931  RASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEE 990
            R  ELR +E+     R  LE+E++  R E+ER        +LR +E E   +      ++
Sbjct: 1363 REEELRHQEQG----RKFLEEEQRLRRQERER-KFLKEEQQLRCQEREQQLR------QD 1411

Query: 991  GERALREA-QQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDL 1047
             +R  RE  QQ+  +++ R    ++QQ R +++E+   +E   L Q+R +  R  + L
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL 1469



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 117/458 (25%), Positives = 204/458 (44%), Gaps = 57/458 (12%)

Query: 577  ELQAELLHSQAR---LAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIK 633
            E + + LH Q R     E E Q+R+ E +R   E  L S Q+  +  LE  +  HR +  
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS-QEPERKFLEEEQQLHRQQ-- 1528

Query: 634  VLETSYQQREERLRRENEELSARYLS--QCQEAEQARAE-----LTAQHQRRLAAIAQEK 686
              +  + Q E++LRR+      R     + +E EQ R E     L+ Q + R   + ++K
Sbjct: 1529 -RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587

Query: 687  DQEMERLRELQRASILDMRRDHEEQLQRLK---------LLKDREVDAATSATSHTRSLN 737
             +  E+ R+         R++ ++QL++ +         LL++RE           + L 
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647

Query: 738  SI--IHQMEKFSSSLHELSS--RVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRD- 792
                + + E+     H+     R E   L   +E++L  ++RD + R  +++L +Q+R+ 
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER 1707

Query: 793  ---MEEERSRQQEVIGKM--EARL---NEQSRLLEQERWRVTAEQSKAESMQRALEEQRK 844
                EE++ R+QE+  K   E +L    EQ +L  QER+R   E+   E ++   EEQ  
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE---EQLRPEREEQ-- 1762

Query: 845  VTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREA 904
               Q    ER    R +  L +E++   L+  E  R+       F  +++L +ER E++ 
Sbjct: 1763 ---QLRRQERDRKFREEEQLRQEREEQQLRSQESDRK-------FREEEQLRQEREEQQL 1812

Query: 905  ERALQVDTQREGTLISLAKEQAELKIRAS---ELRAEEKQLAAERAALEQERQELRLEKE 961
             R  Q D +       L  E+ E ++R     + RAEE+    E++   +E QEL  E+E
Sbjct: 1813 -RPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS--RREEQELWQEEE 1869

Query: 962  RINATALRVKLRAEEVESMSKVASEKYEEGERALREAQ 999
            +        KLR E +    K      + GE   +E +
Sbjct: 1870 QKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 112/505 (22%), Positives = 218/505 (43%), Gaps = 30/505 (5%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQ 618
            E +K+L   + + Q    E   +L   +  L E + + R  E  R Q        +++ +
Sbjct: 826  EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885

Query: 619  ADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRR 678
                  + A + +++  +   Q+ EE L+RE  E   R   Q QE +    E   Q + +
Sbjct: 886  RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRR---QEQERQYREEEQLQQEEEQ 942

Query: 679  LAAIAQEKDQEMERLRELQRASILDMRRDH---EEQLQRLKLLKDREVDAATSATSHTRS 735
            L    +EK +  ER R+ ++   L  + +    EE  +R +  ++++             
Sbjct: 943  LLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ 1002

Query: 736  LNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEE 795
            L  +  + EK      E   R +       QE E  +R+  E+ R LQER  +Q R+ EE
Sbjct: 1003 L--LREEREKRRRQEWERQYRKKDE---LQQEEEQLLREEREK-RRLQER-ERQYREEEE 1055

Query: 796  ERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERA 855
             +  +++++G+ E     +  L  Q R     +Q + + ++   E++R+   ++   E  
Sbjct: 1056 LQQEEEQLLGE-ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE 1114

Query: 856  ELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKE---RAEREAERALQVDT 912
            EL++ +  LL E++    +   ER+    E  +   +Q L +E   R  +E ER  + + 
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE 1174

Query: 913  QREGTLISLAKEQAELKI--RASELRAEE---KQLAAERAALEQERQELRLEKERINATA 967
            + +     L +E+ E +   R  + R EE   +Q   +R   E +R +L+ + E     A
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA 1234

Query: 968  LR---VKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024
            +R   V  +  E E   ++   +  +  ++ ++ Q +  EQQ R     ++QER R Q++
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQLRD-RQSQQDLQHLLGEQQER----DREQERRRWQQR 1289

Query: 1025 HMHQEHLSLAQQRLQLDRARQDLPS 1049
              H       ++  Q +  R+D  S
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKS 1314



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 117/501 (23%), Positives = 213/501 (42%), Gaps = 47/501 (9%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQ 618
            E  +QL  +Q++ + S  +LQ  L   Q R  E E   R+   +R +H        ++ Q
Sbjct: 1248 EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQE---RRRWQQRDRH------FPEEEQ 1298

Query: 619  ADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRR 678
             + E  + A R   K  E     REER  +   + + R   + ++  Q R E   + Q R
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358

Query: 679  LAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNS 738
                   K +E E   + Q    L+  +    Q +  K LK+ +           R    
Sbjct: 1359 -----DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413

Query: 739  IIHQMEKFSSSLHELSSRV-EASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEER 797
               + E+   S  E   +  E       QERE    + ++QLR  + R  +++  + +ER
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER 1473

Query: 798  SRQQEVIGKMEAR-LNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAE 856
              QQ    + + + L E+ +L  QER R   EQ       R+ E +RK   ++  + R +
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL-----RSQEPERKFLEEEQQLHRQQ 1528

Query: 857  LERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAER-----EAERALQVD 911
              R +  L EEQ+    + G++RR+      +F  +++L +ER E+     E +R  +++
Sbjct: 1529 --RQRKFLQEEQQLRRQERGQQRRQDRDR--KFREEEQLRQEREEQQLSRQERDRKFRLE 1584

Query: 912  TQ---REGTLISLAKEQAELKIRASE--LRAEEKQLAAERAALEQERQELRLEKERINAT 966
             Q   R+       +++ +L+ +  +  LR E  +   E   L QER+E +L ++  +  
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK 1644

Query: 967  ALRVK---LRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQE 1023
             L  +    R E  + +      K+ E E+ L+E ++ Q  +Q R         + R++E
Sbjct: 1645 FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER-------DRKFREEE 1697

Query: 1024 QHMHQE--HLSLAQQRLQLDR 1042
            Q + ++       Q+  QL R
Sbjct: 1698 QQLRRQERERKFLQEEQQLRR 1718



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 76/321 (23%), Positives = 145/321 (45%), Gaps = 37/321 (11%)

Query: 762  LTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQ---EVIGKMEARLNEQSRLL 818
            L   + +E   R+ + + R L+E  GQ++R   +E+ R+    E   + + RL ++ R  
Sbjct: 109  LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168

Query: 819  -EQERWRVTAEQSKAESMQRALEEQRKVTA-----------QQMAMERAELERA----KS 862
             ++E WR   E  + E  +RA EEQ +              Q    E  EL R     K 
Sbjct: 169  RDEELWRQRQEWQEREE-RRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ 227

Query: 863  ALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLA 922
                E++  + +  EE+     E      ++KL +E  +R+ E   + +  R+     L 
Sbjct: 228  QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287

Query: 923  KEQAELKIRASELR----------------AEEKQLAAERAALEQERQELRLEKERINAT 966
            +E+ E + +   LR                 EE++   ER   ++ER+E +L +E+    
Sbjct: 288  RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347

Query: 967  ALRVKLRAEEVESMSKVASEKYEE-GERALREAQQVQAEQQARLQAVQQQQERLRKQEQH 1025
              +++   EE     ++  E+ EE  E+ LR  QQ++ EQQ R +   +++++LR+++Q 
Sbjct: 348  EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407

Query: 1026 MHQEHLSLAQQRLQLDRARQD 1046
              ++ L   QQ  +  + R++
Sbjct: 408  RREQQLRREQQLRREQQLRRE 428



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 73/299 (24%), Positives = 139/299 (46%), Gaps = 47/299 (15%)

Query: 786  LGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKV 845
            LGQ     EE+R+R       ++ R  E+ +   + R R   E+      Q+  E++R++
Sbjct: 89   LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL 148

Query: 846  ------TAQQMAMERAELERAKSALLEEQKSVMLKCGEERRR--------LAAEWAEFSA 891
                  + +Q  +E+ + +R    L  +++    +  EERR            E  EF  
Sbjct: 149  AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER--EERRAEEEQLQSCKGHETEEFPD 206

Query: 892  QQKL----------------SKERAEREAERALQVDTQRE----GTLISLAKE--QAELK 929
            +++L                 ++R ER+ +R  Q + ++E     T++   +E  Q E  
Sbjct: 207  EEQLRRRELLELRRKGREEKQQQRRERQ-DRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265

Query: 930  IRASELRAEEKQL-AAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKY 988
             R  EL+ EE+QL   ER  L +ERQE   +++R+       +LR ++ E   +   E+ 
Sbjct: 266  QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR---EQQLRRKQEEERREQQEERR 322

Query: 989  EEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDL 1047
            E+ ER  RE Q+ + EQQ R +  ++++++LR++++   +E     +Q  + +R  Q L
Sbjct: 323  EQQER--REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ--EEERREQQL 377



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 66/301 (21%), Positives = 132/301 (43%), Gaps = 27/301 (8%)

Query: 577  ELQAELLHSQAR---LAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIK 633
            E + + LH Q R     E E Q+R+ E E+     L     ++ + + +L++     +++
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQEREQQ----LRHDRDRKFREEEQLLQEGEEQQLR 1685

Query: 634  VLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERL 693
              E   + REE  +   +E   ++L   QE +Q R +   +  R    + QE +QE  R 
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFL---QEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742

Query: 694  RELQRASILD--MRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLH 751
            +E  R  + +  +R + EEQ      L+ +E D         R       + ++  S   
Sbjct: 1743 QERYRKILEEEQLRPEREEQQ-----LRRQERDRKFREEEQLRQER----EEQQLRSQES 1793

Query: 752  ELSSRVEASHLTTSQERELGIRQRDEQLRALQERLG--QQQRDMEEERSRQ----QEVIG 805
            +   R E       +E++L  +QRD + R  +E+L   +Q++ + +ER RQ    ++   
Sbjct: 1794 DRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFAT 1853

Query: 806  KMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALL 865
            + ++R  EQ    E+E+ R    + K        +++ +   +Q+   +++  +    LL
Sbjct: 1854 QEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLL 1913

Query: 866  E 866
            E
Sbjct: 1914 E 1914


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  110 bits (276), Expect = 6e-24
 Identities = 142/589 (24%), Positives = 258/589 (43%), Gaps = 88/589 (14%)

Query: 559  EYQKQLLAAQVQLQCSPA----ELQAELLHSQARLAE--LEAQVRKLELERAQHELLLGS 612
            E Q+QL  A  Q +        ELQ  +     R  E  ++AQ +K  ++    +L   S
Sbjct: 1370 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1429

Query: 613  LQQQHQADLELIESAHRSRIKV----------LETSYQQRE------ERLRRENEELSAR 656
             + + QA     E+A RSR+++          LE + +QR       + LR   EE  A+
Sbjct: 1430 -EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1488

Query: 657  YLSQCQEAEQARAELTAQHQRRLAA---IAQEKDQEMERLRELQRA--SILDMRRDHEEQ 711
                 +EAE+ R ++  + QR+  A   +A     E E  RE QRA  ++ ++R   EE 
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548

Query: 712  LQRLK---LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             +RL+   + + R+V  A   T+   +   +  +   F+    +L   ++  H+  +Q R
Sbjct: 1549 ERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIG-KMEARLNEQSRLLEQERWRVTA 827
            E   R+  +Q  A + R  + +R++E  + +  E +  +++A    Q + L Q       
Sbjct: 1608 EEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666

Query: 828  EQSKAESMQRALEEQRKVTAQQMAMERAELER------AKSALLEEQKSVMLKC----GE 877
            E+++ E+ +R   E++ V  +++A +  E +R      A+  L  EQ+ + L+     GE
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726

Query: 878  ERRRL----------------------AAEWAEFSAQQKL---SKERAEREAERALQVDT 912
            ++R+L                       AE A+  A+ ++   SK RAE E+    +   
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786

Query: 913  QR----EGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATAL 968
            QR     G    LA+E A L+  A E +  ++QLA E AA +      R E ER+ A  L
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAK-RQRQLAEEDAARQ------RAEAERVLAEKL 1839

Query: 969  RVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQA--------VQQQQERLR 1020
                 A  +++ +++A ++ E     LR   + +A Q+ RL+         ++++  +LR
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 1021 KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSAL 1069
            K      +    L +  L+  R  ++   +L   F +A    A  +  L
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1948



 Score =  108 bits (270), Expect = 3e-23
 Identities = 127/512 (24%), Positives = 231/512 (45%), Gaps = 62/512 (12%)

Query: 568  QVQLQCSP-AELQA---ELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ------H 617
            Q Q+Q  P A+ QA   +L   QA L E+E    K+E  +   +  + +++        +
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289

Query: 618  QADLELIES-AHRSRIKVLETSYQQREERLRRENEELS----------ARYLSQCQEAEQ 666
            +A LE + S A + +++    S  Q    LR    EL+          +  L + +E E+
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 667  ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAA 726
               +  A+ + RLA +    +++ + L E    +     R+ +E  QR++    R  +AA
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408

Query: 727  TSATSHTRSLNSIIHQMEKFSSSLHELSSR----VEASHLTTSQERELGIRQRDEQLRAL 782
              A    RS+   + Q+ + S +  +  +R     E S L   +E    IR    QL A 
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE----IRVVRLQLEAT 1464

Query: 783  QERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ 842
            + + G  + +++  R+R +      EA   ++    E ER R   +       Q  +E  
Sbjct: 1465 ERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518

Query: 843  RKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAER 902
             +V A+      AE  R K   L+  + + L+  E  RRL     E + Q +++ E A+R
Sbjct: 1519 SRVKAE------AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 903  EAERALQVDTQREGTLISLAKEQAELK-------IRASELRAEEKQLAAERAALEQERQE 955
             AE  LQ          S A++ A+L+       +  ++LR E ++ A ++A  E+ R+E
Sbjct: 1573 SAEAELQ------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626

Query: 956  LRLEKERINA---TALRVKLRAEEV---ESMSKVASEKY-EEGERALREAQQVQAEQQAR 1008
               E ER       ALR++L+AEEV   +S+++  +EK  EE ER  R   + + +   +
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686

Query: 1009 LQAVQQQQERLRKQEQHMHQEHLSLAQQRLQL 1040
             +  +Q+ E+ R+  +   Q+ L+  Q+ ++L
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718



 Score =  106 bits (264), Expect = 1e-22
 Identities = 135/556 (24%), Positives = 256/556 (46%), Gaps = 56/556 (10%)

Query: 551  ARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLL 610
            AR    + E +++   A+ ++Q S A  +      +A L E+E    K+E  R   E   
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2026

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSY----QQREERLRRENEELSARYLSQCQEAEQ 666
               +Q+    L+L + A + R++  E ++    QQ+E+ L++  ++  +       EAE 
Sbjct: 2027 -RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085

Query: 667  ARAELTAQHQRRLAA--IAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVD 724
            AR       + R+ A   A +  +++E    L++++    +   + Q    KL K+ E +
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145

Query: 725  AATSATSHTRSL------NSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR--- 775
            AA  A +   +L      ++ + + +KF+       ++VE    T   + E    Q+   
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205

Query: 776  DEQLRALQ---ERLGQQQRDMEEERSR---QQEVIGKMEARLNEQSR--LLEQERWRVTA 827
            DE+L+ L+       +Q+  +EEE      Q E + K++AR+  ++R  +L  +      
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265

Query: 828  EQSKAESMQRALEEQRK--VTAQQMAMER--AELERAKS-ALLEEQKSVMLKCGEERRRL 882
             Q +AE M++  EE  +  V AQ+ A  R  AE + A+  AL E+     ++  +E  RL
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 883  AAEWAEFSAQQKLSKERAER----EAERALQVDTQREG---TLISLAKEQAELKIRASEL 935
             AE      Q++L++E+A R    + + A Q+  + +G   TL +  + Q E+   A  L
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385

Query: 936  RAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEE----VESMSKVASEKYEEG 991
            +    +++  +A  E++ Q  R + E I     R +L  +E    V+++     +   + 
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445

Query: 992  ERALREA------QQVQAEQQARLQAVQQ------QQERLRKQEQHMHQEHLSLAQQRLQ 1039
            ER LREA      ++ + +Q+A+L  ++       QQE+L ++ Q + Q  LS     LQ
Sbjct: 2446 ER-LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504

Query: 1040 LDRARQDLPSSLVGLF 1055
             +R  +   + L  LF
Sbjct: 2505 RERFIEQEKAKLEQLF 2520



 Score =  105 bits (261), Expect = 3e-22
 Identities = 127/515 (24%), Positives = 219/515 (42%), Gaps = 69/515 (13%)

Query: 568  QVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESA 627
            QV L+ +    +AEL   +A  AE  AQ+ +             SLQ++H A  +L E A
Sbjct: 1564 QVALETAQRSAEAELQSKRASFAEKTAQLER-------------SLQEEHVAVAQLREEA 1610

Query: 628  HRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD 687
             R          Q   ER R E E    R+  +  EA + R +     Q++  A A+ + 
Sbjct: 1611 ER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664

Query: 688  QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATS-----ATSHTRSLNSIIHQ 742
            Q+ E  RE +R    + +   + +L   +L K R++   T+     A      L +   Q
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1724

Query: 743  MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQE 802
             E+    L E  +R++      +Q+R+    +  +    ++  L  + R  EE RS  ++
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1784

Query: 803  VIGKMEARLNEQSRLLEQE-RWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERA- 860
               ++EA       L E+  R R  AE++K          QR++  +  A +RAE ER  
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEEAK---------RQRQLAEEDAARQRAEAERVL 1835

Query: 861  --------KSALLEEQKSVMLKC----GEERRRLAAEWA-------EFSAQQKLSKERAE 901
                    ++  L+ +  + LK      E  RRLA + A       E +AQ K   E   
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 902  REAERALQVDTQREGTLIS-LAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLE- 959
             +  +A   + +R+  L+    +++ +++     L+A  ++ AA +A LE E   +R   
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955

Query: 960  ------KERINATALRVKLRAEEVESMSKVASEKYEEGERALREA---QQVQAEQQARLQ 1010
                  KE+    A R +  A E E   + A E+ ++   A  EA   ++   E+  RL+
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015

Query: 1011 AVQQQQERLRKQEQHMHQEHLSLAQQ----RLQLD 1041
            A  ++  RLR++ +      L LAQ+    RLQ +
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050



 Score =  103 bits (258), Expect = 7e-22
 Identities = 133/554 (24%), Positives = 245/554 (44%), Gaps = 78/554 (14%)

Query: 559  EYQKQLLAAQVQLQ---CSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLG---- 611
            + ++++LA +   +      AEL+ EL   ++   +      + ELE A+   L      
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 612  ---SLQQQHQADLELIESAHRSRIKVLE-----TSYQQREERLRRENEELSARYLSQCQE 663
                 +++ Q  L   E A R R   LE      +  +   RLR   E+ SAR L   QE
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2041

Query: 664  AEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQR-LKLLKDRE 722
            A Q R  L A+ +    A+ Q+K+QE+++  + Q  S+LD  R   E  +R  +  ++  
Sbjct: 2042 AAQKR--LQAEEKAHAFAV-QQKEQELQQTLQ-QEQSVLDQLRGEAEAARRAAEEAEEAR 2097

Query: 723  VDAATSATSHTRSLNSIIHQMEKFSSSLHE-----LSSRVEASHLTTSQERELGIRQRDE 777
            V A   A    R     + + E+   S  E       ++  A  L    E+E   R + E
Sbjct: 2098 VQAEREAAQSRRQ----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 778  QLRALQERLGQQQRDMEE--------ERSRQQEVIGKMEARLNE---QSRLLEQERWRVT 826
            Q    Q++    + +  +        ++++ ++ +  +  +L E   Q  LL++E  R+ 
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213

Query: 827  AEQSKAESMQRALEEQR---KVTAQQMAMERAELERAKSAL-----------LEEQKSVM 872
            AE ++A   +  +EE+    +V  ++++  +A +E    AL           L+E+   M
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273

Query: 873  LKCGEERRRL--AAEWA--------EFSAQQKLSKERAEREAERALQVDTQREGTLISLA 922
             +  EE  RL  AA+ A        E  AQQ+   E+  +E  +A+Q  T+ +     L 
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELL 2332

Query: 923  KEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKER-----INATALRVKLRAEEV 977
            ++Q EL    +    E+K+  A++ A E +  +  LE ER     ++A A R+KLR  E 
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE- 2391

Query: 978  ESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQ----ERLRKQEQHMHQEHLSL 1033
              MS+  +   E+ +R  ++A+++  E+  R +   Q++    + L  Q Q    +   L
Sbjct: 2392 --MSRAQARAEEDAQRFRKQAEEI-GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448

Query: 1034 AQQRLQLDRARQDL 1047
             +   +L+R ++ L
Sbjct: 2449 REAIAELEREKEKL 2462



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 140/533 (26%), Positives = 239/533 (44%), Gaps = 74/533 (13%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            QK L  A+ + Q   AE +A         A  + ++ + ELE+ Q +L  G+ QQ+  A+
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAE 1712

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLA 680
             ELI    R+  +  E   Q  EE L R   E +A    + QE E   A++ A+ +  LA
Sbjct: 1713 QELIRL--RAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLA 1769

Query: 681  AIAQEKDQEMERLRELQRASILDMRRDHE--EQLQRLKLLKDR--------EVDAATSAT 730
            + A+ +++      + ++    +  R  E  E+  RL+ L +         E DAA    
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829

Query: 731  SHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRD---EQLRALQERLG 787
               R L               +L++  EA+ L T  E E+ +++++   E+LR L E   
Sbjct: 1830 EAERVL-------------AEKLAAIGEATRLKT--EAEIALKEKEAENERLRRLAEDEA 1874

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ---RK 844
             Q+R +EE+ ++ +  I +  A+L + S   E ER +   E +  +  +R +EE+    K
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDS-ELERQKGLVEDTLRQ--RRQVEEEILALK 1931

Query: 845  VTAQQMAMERAELE--------------RAKS-ALLEEQKSVMLKCGEERRR-------- 881
             + ++ A  +AELE              R+K  A LE  +   L   EERRR        
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991

Query: 882  --LAAEWAEFSAQQKLSKERAER------EAERALQVDTQREGTLISLAKEQAELKIRAS 933
              LAAE  E + Q+K + E  ER      EA R  +   Q     + LA+E A+ +++A 
Sbjct: 1992 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050

Query: 934  ELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGER 993
            E +A    +  +   L+Q  Q+ +   +++   A   +  AEE E     A  +  +  R
Sbjct: 2051 E-KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109

Query: 994  ALREAQQVQ--AEQQARLQA-VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRA 1043
             + EA++++  AE+QA+ +A  Q   E+LRK+ +          Q  L+  +A
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 149/642 (23%), Positives = 264/642 (41%), Gaps = 160/642 (24%)

Query: 559  EYQKQLLAAQVQLQCSPAE--LQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ 616
            E  +Q  A Q+QL    A+  LQAE    +A    ++ + ++L+    Q + +L  L+ +
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082

Query: 617  HQADLELIESAHRSRIKVLETSYQQRE-----ERLRRENEELS-ARYLSQC------QEA 664
             +A     E A  +R++    + Q R      ERL++  EE + AR  +Q       +EA
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142

Query: 665  EQ-----ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASI--------LDMRR-DHEE 710
            EQ     A+AE  A  Q++ A    EK ++       Q+A +        L +   DH++
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202

Query: 711  QL--QRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             L  + L+ LK    +AA   +     L S+  QME+ S    +L +R+EA      + R
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS----KLKARIEA------ENR 2252

Query: 769  ELGIRQRDEQLRALQERLGQQQ-------------------RDMEEERSRQQEVIG---- 805
             L +R +D   R LQE   + +                   R + EE   QQ  +     
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312

Query: 806  --KMEA-----RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELE 858
              KM+A     RL  ++ LL+Q++         A+   R L+E ++  AQQ+A E    +
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQK-------ELAQEQARRLQEDKEQMAQQLAEETQGFQ 2365

Query: 859  RAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVD------- 911
            R     LE ++   L+   E  RL    AE S  Q  ++E A+R  ++A ++        
Sbjct: 2366 RT----LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421

Query: 912  --TQREGTLISLA------------------------KEQAELKIRASELRAEEKQ---- 941
              TQ + TL+                           KE+ + + +  +L++EE Q    
Sbjct: 2422 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481

Query: 942  ---------------------------LAAERAALEQ-------ERQELRLEKERINATA 967
                                       +  E+A LEQ       + Q+LR E++R     
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 968  LRVKLRAEEVESMSKVASEKYEEGE---RALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024
             + + R   V SM +    ++E  E   R   E QQ++ +++ + + + ++ +RLR+Q Q
Sbjct: 2542 EQERQRL--VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599

Query: 1025 HMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQ 1066
             + ++H +      ++  ++     +L        GPAA ++
Sbjct: 2600 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2641



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 125/546 (22%), Positives = 243/546 (44%), Gaps = 76/546 (13%)

Query: 560  YQKQLLAAQV------QLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSL 613
            +++QL  AQ       +L+ + A L+   L +QA   +      + EL  AQ    +G  
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKK--LRAQAEAQQPTFDALRDELRGAQE---VGER 1162

Query: 614  QQQHQADLELIESAHRSRIKVL---------ETSYQQRE-ERLRRE-------NEELSA- 655
             QQ   + ++     R R+  L         +T  +QRE E+L R+        + L A 
Sbjct: 1163 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1222

Query: 656  -----RYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRAS--ILDMRRDH 708
                 R   Q Q    A ++   +  R+  A+ +E ++  E++ E QR +   ++  +D+
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282

Query: 709  EEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
            E QL   K   +     A      + S  S+I +     +   EL++        TSQ  
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTT-------LTSQY- 1333

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAE 828
               I+   E LR ++E    ++R  E++R+ ++E + ++EA L +Q +L E         
Sbjct: 1334 ---IKFISETLRRMEE----EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1386

Query: 829  QSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEE--QKSVMLKCGEERRRLAAEW 886
            + +A+ +Q+ ++E+  V  ++ A++  + +R+    L++  Q S      + R+  AAE 
Sbjct: 1387 EREAKELQQRMQEE-VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAE-------- 938
            +    ++++   R + EA    +   + E   +    E+AE + R ++  AE        
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505

Query: 939  ----EKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVAS-EKYEEGER 993
                ++Q   E A+  +   E   EK+R       ++L+AEE E   + A  E+  + + 
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1565

Query: 994  ALREAQQ-VQAEQQARLQAVQQQQERLRK--QEQHMH-----QEHLSLAQQRLQLDRARQ 1045
            AL  AQ+  +AE Q++  +  ++  +L +  QE+H+      +E    AQQ+ + +RAR+
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625

Query: 1046 DLPSSL 1051
            +    L
Sbjct: 1626 EAEREL 1631



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 93/427 (21%), Positives = 162/427 (37%), Gaps = 71/427 (16%)

Query: 662  QEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDR 721
            QEA++A   L AQHQ  L  +  +   +M+ L   Q      +RRD       ++L+  R
Sbjct: 863  QEAQEAVTRLEAQHQA-LVTLWHQLHVDMKSLLAWQ-----SLRRD-------VQLI--R 907

Query: 722  EVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRA 781
                AT  T         +H +E    +   L    +A      ++R +  R+       
Sbjct: 908  SWSLATFRTLKPEEQRQALHSLELHYQAF--LRDSQDAGGFGP-EDRLMAEREYGSCSHH 964

Query: 782  LQERLGQQQRDMEEERSRQQEVIGKMEARLN-EQSRLLEQERWRVTAEQSKAESMQRALE 840
             Q+ L   ++  +EE   Q+ +    + RL  E        R R+  ++  A    + + 
Sbjct: 965  YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1024

Query: 841  EQRKVTAQQMAMER------AELERA--------KSALLEEQKSVMLKCGEERRRLAAEW 886
            EQ+K  A+   + +      AE E+          +  L  +  + L   E+ R L+A +
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1084

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQR--------------EGTLISLAKEQAELKIR- 931
             E      L   R  + AE  L+   ++              E T  SL K +A+ + + 
Sbjct: 1085 LEKLKTISLVI-RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143

Query: 932  ------------ASELRAEEKQLAAER-AALEQERQELRLEKERINATALRVKLRAEEVE 978
                        A E+    +Q   ER   +E+ R+ +    ER  A   +  +R  E+E
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1203

Query: 979  SMSKVASEKYEEG-------ERALREAQQVQAEQQARLQAVQQQ--QERLRKQEQHMHQE 1029
             + +      E         + A R  +Q+QA   A  QAV++Q  QE+   +E   H E
Sbjct: 1204 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1263

Query: 1030 HLSLAQQ 1036
             +   Q+
Sbjct: 1264 KVEECQR 1270


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  110 bits (276), Expect = 6e-24
 Identities = 142/589 (24%), Positives = 258/589 (43%), Gaps = 88/589 (14%)

Query: 559  EYQKQLLAAQVQLQCSPA----ELQAELLHSQARLAE--LEAQVRKLELERAQHELLLGS 612
            E Q+QL  A  Q +        ELQ  +     R  E  ++AQ +K  ++    +L   S
Sbjct: 1374 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1433

Query: 613  LQQQHQADLELIESAHRSRIKV----------LETSYQQRE------ERLRRENEELSAR 656
             + + QA     E+A RSR+++          LE + +QR       + LR   EE  A+
Sbjct: 1434 -EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1492

Query: 657  YLSQCQEAEQARAELTAQHQRRLAA---IAQEKDQEMERLRELQRA--SILDMRRDHEEQ 711
                 +EAE+ R ++  + QR+  A   +A     E E  RE QRA  ++ ++R   EE 
Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1552

Query: 712  LQRLK---LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             +RL+   + + R+V  A   T+   +   +  +   F+    +L   ++  H+  +Q R
Sbjct: 1553 ERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1611

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIG-KMEARLNEQSRLLEQERWRVTA 827
            E   R+  +Q  A + R  + +R++E  + +  E +  +++A    Q + L Q       
Sbjct: 1612 EEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670

Query: 828  EQSKAESMQRALEEQRKVTAQQMAMERAELER------AKSALLEEQKSVMLKC----GE 877
            E+++ E+ +R   E++ V  +++A +  E +R      A+  L  EQ+ + L+     GE
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730

Query: 878  ERRRL----------------------AAEWAEFSAQQKL---SKERAEREAERALQVDT 912
            ++R+L                       AE A+  A+ ++   SK RAE E+    +   
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1790

Query: 913  QR----EGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATAL 968
            QR     G    LA+E A L+  A E +  ++QLA E AA +      R E ER+ A  L
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAK-RQRQLAEEDAARQ------RAEAERVLAEKL 1843

Query: 969  RVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQA--------VQQQQERLR 1020
                 A  +++ +++A ++ E     LR   + +A Q+ RL+         ++++  +LR
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903

Query: 1021 KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSAL 1069
            K      +    L +  L+  R  ++   +L   F +A    A  +  L
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1952



 Score =  108 bits (270), Expect = 3e-23
 Identities = 127/512 (24%), Positives = 231/512 (45%), Gaps = 62/512 (12%)

Query: 568  QVQLQCSP-AELQA---ELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ------H 617
            Q Q+Q  P A+ QA   +L   QA L E+E    K+E  +   +  + +++        +
Sbjct: 1234 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1293

Query: 618  QADLELIES-AHRSRIKVLETSYQQREERLRRENEELS----------ARYLSQCQEAEQ 666
            +A LE + S A + +++    S  Q    LR    EL+          +  L + +E E+
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353

Query: 667  ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAA 726
               +  A+ + RLA +    +++ + L E    +     R+ +E  QR++    R  +AA
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1412

Query: 727  TSATSHTRSLNSIIHQMEKFSSSLHELSSR----VEASHLTTSQERELGIRQRDEQLRAL 782
              A    RS+   + Q+ + S +  +  +R     E S L   +E    IR    QL A 
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE----IRVVRLQLEAT 1468

Query: 783  QERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ 842
            + + G  + +++  R+R +      EA   ++    E ER R   +       Q  +E  
Sbjct: 1469 ERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1522

Query: 843  RKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAER 902
             +V A+      AE  R K   L+  + + L+  E  RRL     E + Q +++ E A+R
Sbjct: 1523 SRVKAE------AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1576

Query: 903  EAERALQVDTQREGTLISLAKEQAELK-------IRASELRAEEKQLAAERAALEQERQE 955
             AE  LQ          S A++ A+L+       +  ++LR E ++ A ++A  E+ R+E
Sbjct: 1577 SAEAELQ------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1630

Query: 956  LRLEKERINA---TALRVKLRAEEV---ESMSKVASEKY-EEGERALREAQQVQAEQQAR 1008
               E ER       ALR++L+AEEV   +S+++  +EK  EE ER  R   + + +   +
Sbjct: 1631 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690

Query: 1009 LQAVQQQQERLRKQEQHMHQEHLSLAQQRLQL 1040
             +  +Q+ E+ R+  +   Q+ L+  Q+ ++L
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1722



 Score =  106 bits (264), Expect = 1e-22
 Identities = 135/556 (24%), Positives = 256/556 (46%), Gaps = 56/556 (10%)

Query: 551  ARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLL 610
            AR    + E +++   A+ ++Q S A  +      +A L E+E    K+E  R   E   
Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2030

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSY----QQREERLRRENEELSARYLSQCQEAEQ 666
               +Q+    L+L + A + R++  E ++    QQ+E+ L++  ++  +       EAE 
Sbjct: 2031 -RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2089

Query: 667  ARAELTAQHQRRLAA--IAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVD 724
            AR       + R+ A   A +  +++E    L++++    +   + Q    KL K+ E +
Sbjct: 2090 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2149

Query: 725  AATSATSHTRSL------NSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR--- 775
            AA  A +   +L      ++ + + +KF+       ++VE    T   + E    Q+   
Sbjct: 2150 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2209

Query: 776  DEQLRALQ---ERLGQQQRDMEEERSR---QQEVIGKMEARLNEQSR--LLEQERWRVTA 827
            DE+L+ L+       +Q+  +EEE      Q E + K++AR+  ++R  +L  +      
Sbjct: 2210 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2269

Query: 828  EQSKAESMQRALEEQRK--VTAQQMAMER--AELERAKS-ALLEEQKSVMLKCGEERRRL 882
             Q +AE M++  EE  +  V AQ+ A  R  AE + A+  AL E+     ++  +E  RL
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329

Query: 883  AAEWAEFSAQQKLSKERAER----EAERALQVDTQREG---TLISLAKEQAELKIRASEL 935
             AE      Q++L++E+A R    + + A Q+  + +G   TL +  + Q E+   A  L
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389

Query: 936  RAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEE----VESMSKVASEKYEEG 991
            +    +++  +A  E++ Q  R + E I     R +L  +E    V+++     +   + 
Sbjct: 2390 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2449

Query: 992  ERALREA------QQVQAEQQARLQAVQQ------QQERLRKQEQHMHQEHLSLAQQRLQ 1039
            ER LREA      ++ + +Q+A+L  ++       QQE+L ++ Q + Q  LS     LQ
Sbjct: 2450 ER-LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508

Query: 1040 LDRARQDLPSSLVGLF 1055
             +R  +   + L  LF
Sbjct: 2509 RERFIEQEKAKLEQLF 2524



 Score =  105 bits (261), Expect = 3e-22
 Identities = 127/515 (24%), Positives = 219/515 (42%), Gaps = 69/515 (13%)

Query: 568  QVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESA 627
            QV L+ +    +AEL   +A  AE  AQ+ +             SLQ++H A  +L E A
Sbjct: 1568 QVALETAQRSAEAELQSKRASFAEKTAQLER-------------SLQEEHVAVAQLREEA 1614

Query: 628  HRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD 687
             R          Q   ER R E E    R+  +  EA + R +     Q++  A A+ + 
Sbjct: 1615 ER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1668

Query: 688  QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATS-----ATSHTRSLNSIIHQ 742
            Q+ E  RE +R    + +   + +L   +L K R++   T+     A      L +   Q
Sbjct: 1669 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1728

Query: 743  MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQE 802
             E+    L E  +R++      +Q+R+    +  +    ++  L  + R  EE RS  ++
Sbjct: 1729 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1788

Query: 803  VIGKMEARLNEQSRLLEQE-RWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERA- 860
               ++EA       L E+  R R  AE++K          QR++  +  A +RAE ER  
Sbjct: 1789 SKQRLEAEAGRFRELAEEAARLRALAEEAK---------RQRQLAEEDAARQRAEAERVL 1839

Query: 861  --------KSALLEEQKSVMLKC----GEERRRLAAEWA-------EFSAQQKLSKERAE 901
                    ++  L+ +  + LK      E  RRLA + A       E +AQ K   E   
Sbjct: 1840 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899

Query: 902  REAERALQVDTQREGTLIS-LAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLE- 959
             +  +A   + +R+  L+    +++ +++     L+A  ++ AA +A LE E   +R   
Sbjct: 1900 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1959

Query: 960  ------KERINATALRVKLRAEEVESMSKVASEKYEEGERALREA---QQVQAEQQARLQ 1010
                  KE+    A R +  A E E   + A E+ ++   A  EA   ++   E+  RL+
Sbjct: 1960 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2019

Query: 1011 AVQQQQERLRKQEQHMHQEHLSLAQQ----RLQLD 1041
            A  ++  RLR++ +      L LAQ+    RLQ +
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054



 Score =  103 bits (258), Expect = 7e-22
 Identities = 133/554 (24%), Positives = 245/554 (44%), Gaps = 78/554 (14%)

Query: 559  EYQKQLLAAQVQLQ---CSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLG---- 611
            + ++++LA +   +      AEL+ EL   ++   +      + ELE A+   L      
Sbjct: 1926 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1985

Query: 612  ---SLQQQHQADLELIESAHRSRIKVLE-----TSYQQREERLRRENEELSARYLSQCQE 663
                 +++ Q  L   E A R R   LE      +  +   RLR   E+ SAR L   QE
Sbjct: 1986 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2045

Query: 664  AEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQR-LKLLKDRE 722
            A Q R  L A+ +    A+ Q+K+QE+++  + Q  S+LD  R   E  +R  +  ++  
Sbjct: 2046 AAQKR--LQAEEKAHAFAV-QQKEQELQQTLQ-QEQSVLDQLRGEAEAARRAAEEAEEAR 2101

Query: 723  VDAATSATSHTRSLNSIIHQMEKFSSSLHE-----LSSRVEASHLTTSQERELGIRQRDE 777
            V A   A    R     + + E+   S  E       ++  A  L    E+E   R + E
Sbjct: 2102 VQAEREAAQSRRQ----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2157

Query: 778  QLRALQERLGQQQRDMEE--------ERSRQQEVIGKMEARLNE---QSRLLEQERWRVT 826
            Q    Q++    + +  +        ++++ ++ +  +  +L E   Q  LL++E  R+ 
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2217

Query: 827  AEQSKAESMQRALEEQR---KVTAQQMAMERAELERAKSAL-----------LEEQKSVM 872
            AE ++A   +  +EE+    +V  ++++  +A +E    AL           L+E+   M
Sbjct: 2218 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2277

Query: 873  LKCGEERRRL--AAEWA--------EFSAQQKLSKERAEREAERALQVDTQREGTLISLA 922
             +  EE  RL  AA+ A        E  AQQ+   E+  +E  +A+Q  T+ +     L 
Sbjct: 2278 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELL 2336

Query: 923  KEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKER-----INATALRVKLRAEEV 977
            ++Q EL    +    E+K+  A++ A E +  +  LE ER     ++A A R+KLR  E 
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE- 2395

Query: 978  ESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQ----ERLRKQEQHMHQEHLSL 1033
              MS+  +   E+ +R  ++A+++  E+  R +   Q++    + L  Q Q    +   L
Sbjct: 2396 --MSRAQARAEEDAQRFRKQAEEI-GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2452

Query: 1034 AQQRLQLDRARQDL 1047
             +   +L+R ++ L
Sbjct: 2453 REAIAELEREKEKL 2466



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 140/533 (26%), Positives = 239/533 (44%), Gaps = 74/533 (13%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            QK L  A+ + Q   AE +A         A  + ++ + ELE+ Q +L  G+ QQ+  A+
Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAE 1716

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLA 680
             ELI    R+  +  E   Q  EE L R   E +A    + QE E   A++ A+ +  LA
Sbjct: 1717 QELIRL--RAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLA 1773

Query: 681  AIAQEKDQEMERLRELQRASILDMRRDHE--EQLQRLKLLKDR--------EVDAATSAT 730
            + A+ +++      + ++    +  R  E  E+  RL+ L +         E DAA    
Sbjct: 1774 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1833

Query: 731  SHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRD---EQLRALQERLG 787
               R L               +L++  EA+ L T  E E+ +++++   E+LR L E   
Sbjct: 1834 EAERVL-------------AEKLAAIGEATRLKT--EAEIALKEKEAENERLRRLAEDEA 1878

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ---RK 844
             Q+R +EE+ ++ +  I +  A+L + S   E ER +   E +  +  +R +EE+    K
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDS-ELERQKGLVEDTLRQ--RRQVEEEILALK 1935

Query: 845  VTAQQMAMERAELE--------------RAKS-ALLEEQKSVMLKCGEERRR-------- 881
             + ++ A  +AELE              R+K  A LE  +   L   EERRR        
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1995

Query: 882  --LAAEWAEFSAQQKLSKERAER------EAERALQVDTQREGTLISLAKEQAELKIRAS 933
              LAAE  E + Q+K + E  ER      EA R  +   Q     + LA+E A+ +++A 
Sbjct: 1996 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054

Query: 934  ELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGER 993
            E +A    +  +   L+Q  Q+ +   +++   A   +  AEE E     A  +  +  R
Sbjct: 2055 E-KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2113

Query: 994  ALREAQQVQ--AEQQARLQA-VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRA 1043
             + EA++++  AE+QA+ +A  Q   E+LRK+ +          Q  L+  +A
Sbjct: 2114 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2166



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 149/642 (23%), Positives = 264/642 (41%), Gaps = 160/642 (24%)

Query: 559  EYQKQLLAAQVQLQCSPAE--LQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ 616
            E  +Q  A Q+QL    A+  LQAE    +A    ++ + ++L+    Q + +L  L+ +
Sbjct: 2030 ERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2086

Query: 617  HQADLELIESAHRSRIKVLETSYQQRE-----ERLRRENEELS-ARYLSQC------QEA 664
             +A     E A  +R++    + Q R      ERL++  EE + AR  +Q       +EA
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2146

Query: 665  EQ-----ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASI--------LDMRR-DHEE 710
            EQ     A+AE  A  Q++ A    EK ++       Q+A +        L +   DH++
Sbjct: 2147 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2206

Query: 711  QL--QRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             L  + L+ LK    +AA   +     L S+  QME+ S    +L +R+EA      + R
Sbjct: 2207 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS----KLKARIEA------ENR 2256

Query: 769  ELGIRQRDEQLRALQERLGQQQ-------------------RDMEEERSRQQEVIG---- 805
             L +R +D   R LQE   + +                   R + EE   QQ  +     
Sbjct: 2257 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2316

Query: 806  --KMEA-----RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELE 858
              KM+A     RL  ++ LL+Q++         A+   R L+E ++  AQQ+A E    +
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQK-------ELAQEQARRLQEDKEQMAQQLAEETQGFQ 2369

Query: 859  RAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVD------- 911
            R     LE ++   L+   E  RL    AE S  Q  ++E A+R  ++A ++        
Sbjct: 2370 RT----LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2425

Query: 912  --TQREGTLISLA------------------------KEQAELKIRASELRAEEKQ---- 941
              TQ + TL+                           KE+ + + +  +L++EE Q    
Sbjct: 2426 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2485

Query: 942  ---------------------------LAAERAALEQ-------ERQELRLEKERINATA 967
                                       +  E+A LEQ       + Q+LR E++R     
Sbjct: 2486 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2545

Query: 968  LRVKLRAEEVESMSKVASEKYEEGE---RALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024
             + + R   V SM +    ++E  E   R   E QQ++ +++ + + + ++ +RLR+Q Q
Sbjct: 2546 EQERQRL--VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603

Query: 1025 HMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQ 1066
             + ++H +      ++  ++     +L        GPAA ++
Sbjct: 2604 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2645



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 125/546 (22%), Positives = 243/546 (44%), Gaps = 76/546 (13%)

Query: 560  YQKQLLAAQV------QLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSL 613
            +++QL  AQ       +L+ + A L+   L +QA   +      + EL  AQ    +G  
Sbjct: 1112 HEEQLKEAQAVPATLPELEATKASLKK--LRAQAEAQQPTFDALRDELRGAQE---VGER 1166

Query: 614  QQQHQADLELIESAHRSRIKVL---------ETSYQQRE-ERLRRE-------NEELSA- 655
             QQ   + ++     R R+  L         +T  +QRE E+L R+        + L A 
Sbjct: 1167 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1226

Query: 656  -----RYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRAS--ILDMRRDH 708
                 R   Q Q    A ++   +  R+  A+ +E ++  E++ E QR +   ++  +D+
Sbjct: 1227 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286

Query: 709  EEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
            E QL   K   +     A      + S  S+I +     +   EL++        TSQ  
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTT-------LTSQY- 1337

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAE 828
               I+   E LR ++E    ++R  E++R+ ++E + ++EA L +Q +L E         
Sbjct: 1338 ---IKFISETLRRMEE----EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1390

Query: 829  QSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEE--QKSVMLKCGEERRRLAAEW 886
            + +A+ +Q+ ++E+  V  ++ A++  + +R+    L++  Q S      + R+  AAE 
Sbjct: 1391 EREAKELQQRMQEE-VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAE-------- 938
            +    ++++   R + EA    +   + E   +    E+AE + R ++  AE        
Sbjct: 1450 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1509

Query: 939  ----EKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVAS-EKYEEGER 993
                ++Q   E A+  +   E   EK+R       ++L+AEE E   + A  E+  + + 
Sbjct: 1510 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1569

Query: 994  ALREAQQ-VQAEQQARLQAVQQQQERLRK--QEQHMH-----QEHLSLAQQRLQLDRARQ 1045
            AL  AQ+  +AE Q++  +  ++  +L +  QE+H+      +E    AQQ+ + +RAR+
Sbjct: 1570 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629

Query: 1046 DLPSSL 1051
            +    L
Sbjct: 1630 EAEREL 1635



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 93/427 (21%), Positives = 162/427 (37%), Gaps = 71/427 (16%)

Query: 662  QEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDR 721
            QEA++A   L AQHQ  L  +  +   +M+ L   Q      +RRD       ++L+  R
Sbjct: 867  QEAQEAVTRLEAQHQA-LVTLWHQLHVDMKSLLAWQ-----SLRRD-------VQLI--R 911

Query: 722  EVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRA 781
                AT  T         +H +E    +   L    +A      ++R +  R+       
Sbjct: 912  SWSLATFRTLKPEEQRQALHSLELHYQAF--LRDSQDAGGFGP-EDRLMAEREYGSCSHH 968

Query: 782  LQERLGQQQRDMEEERSRQQEVIGKMEARLN-EQSRLLEQERWRVTAEQSKAESMQRALE 840
             Q+ L   ++  +EE   Q+ +    + RL  E        R R+  ++  A    + + 
Sbjct: 969  YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1028

Query: 841  EQRKVTAQQMAMER------AELERA--------KSALLEEQKSVMLKCGEERRRLAAEW 886
            EQ+K  A+   + +      AE E+          +  L  +  + L   E+ R L+A +
Sbjct: 1029 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1088

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQR--------------EGTLISLAKEQAELKIR- 931
             E      L   R  + AE  L+   ++              E T  SL K +A+ + + 
Sbjct: 1089 LEKLKTISLVI-RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1147

Query: 932  ------------ASELRAEEKQLAAER-AALEQERQELRLEKERINATALRVKLRAEEVE 978
                        A E+    +Q   ER   +E+ R+ +    ER  A   +  +R  E+E
Sbjct: 1148 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1207

Query: 979  SMSKVASEKYEEG-------ERALREAQQVQAEQQARLQAVQQQ--QERLRKQEQHMHQE 1029
             + +      E         + A R  +Q+QA   A  QAV++Q  QE+   +E   H E
Sbjct: 1208 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1267

Query: 1030 HLSLAQQ 1036
             +   Q+
Sbjct: 1268 KVEECQR 1274


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  110 bits (276), Expect = 6e-24
 Identities = 142/589 (24%), Positives = 258/589 (43%), Gaps = 88/589 (14%)

Query: 559  EYQKQLLAAQVQLQCSPA----ELQAELLHSQARLAE--LEAQVRKLELERAQHELLLGS 612
            E Q+QL  A  Q +        ELQ  +     R  E  ++AQ +K  ++    +L   S
Sbjct: 1370 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1429

Query: 613  LQQQHQADLELIESAHRSRIKV----------LETSYQQRE------ERLRRENEELSAR 656
             + + QA     E+A RSR+++          LE + +QR       + LR   EE  A+
Sbjct: 1430 -EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1488

Query: 657  YLSQCQEAEQARAELTAQHQRRLAA---IAQEKDQEMERLRELQRA--SILDMRRDHEEQ 711
                 +EAE+ R ++  + QR+  A   +A     E E  RE QRA  ++ ++R   EE 
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548

Query: 712  LQRLK---LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             +RL+   + + R+V  A   T+   +   +  +   F+    +L   ++  H+  +Q R
Sbjct: 1549 ERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIG-KMEARLNEQSRLLEQERWRVTA 827
            E   R+  +Q  A + R  + +R++E  + +  E +  +++A    Q + L Q       
Sbjct: 1608 EEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666

Query: 828  EQSKAESMQRALEEQRKVTAQQMAMERAELER------AKSALLEEQKSVMLKC----GE 877
            E+++ E+ +R   E++ V  +++A +  E +R      A+  L  EQ+ + L+     GE
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726

Query: 878  ERRRL----------------------AAEWAEFSAQQKL---SKERAEREAERALQVDT 912
            ++R+L                       AE A+  A+ ++   SK RAE E+    +   
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786

Query: 913  QR----EGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATAL 968
            QR     G    LA+E A L+  A E +  ++QLA E AA +      R E ER+ A  L
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAK-RQRQLAEEDAARQ------RAEAERVLAEKL 1839

Query: 969  RVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQA--------VQQQQERLR 1020
                 A  +++ +++A ++ E     LR   + +A Q+ RL+         ++++  +LR
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 1021 KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSAL 1069
            K      +    L +  L+  R  ++   +L   F +A    A  +  L
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1948



 Score =  108 bits (270), Expect = 3e-23
 Identities = 127/512 (24%), Positives = 231/512 (45%), Gaps = 62/512 (12%)

Query: 568  QVQLQCSP-AELQA---ELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ------H 617
            Q Q+Q  P A+ QA   +L   QA L E+E    K+E  +   +  + +++        +
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289

Query: 618  QADLELIES-AHRSRIKVLETSYQQREERLRRENEELS----------ARYLSQCQEAEQ 666
            +A LE + S A + +++    S  Q    LR    EL+          +  L + +E E+
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 667  ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAA 726
               +  A+ + RLA +    +++ + L E    +     R+ +E  QR++    R  +AA
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408

Query: 727  TSATSHTRSLNSIIHQMEKFSSSLHELSSR----VEASHLTTSQERELGIRQRDEQLRAL 782
              A    RS+   + Q+ + S +  +  +R     E S L   +E    IR    QL A 
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE----IRVVRLQLEAT 1464

Query: 783  QERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ 842
            + + G  + +++  R+R +      EA   ++    E ER R   +       Q  +E  
Sbjct: 1465 ERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518

Query: 843  RKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAER 902
             +V A+      AE  R K   L+  + + L+  E  RRL     E + Q +++ E A+R
Sbjct: 1519 SRVKAE------AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 903  EAERALQVDTQREGTLISLAKEQAELK-------IRASELRAEEKQLAAERAALEQERQE 955
             AE  LQ          S A++ A+L+       +  ++LR E ++ A ++A  E+ R+E
Sbjct: 1573 SAEAELQ------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626

Query: 956  LRLEKERINA---TALRVKLRAEEV---ESMSKVASEKY-EEGERALREAQQVQAEQQAR 1008
               E ER       ALR++L+AEEV   +S+++  +EK  EE ER  R   + + +   +
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686

Query: 1009 LQAVQQQQERLRKQEQHMHQEHLSLAQQRLQL 1040
             +  +Q+ E+ R+  +   Q+ L+  Q+ ++L
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718



 Score =  106 bits (264), Expect = 1e-22
 Identities = 135/556 (24%), Positives = 256/556 (46%), Gaps = 56/556 (10%)

Query: 551  ARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLL 610
            AR    + E +++   A+ ++Q S A  +      +A L E+E    K+E  R   E   
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2026

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSY----QQREERLRRENEELSARYLSQCQEAEQ 666
               +Q+    L+L + A + R++  E ++    QQ+E+ L++  ++  +       EAE 
Sbjct: 2027 -RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085

Query: 667  ARAELTAQHQRRLAA--IAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVD 724
            AR       + R+ A   A +  +++E    L++++    +   + Q    KL K+ E +
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145

Query: 725  AATSATSHTRSL------NSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR--- 775
            AA  A +   +L      ++ + + +KF+       ++VE    T   + E    Q+   
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205

Query: 776  DEQLRALQ---ERLGQQQRDMEEERSR---QQEVIGKMEARLNEQSR--LLEQERWRVTA 827
            DE+L+ L+       +Q+  +EEE      Q E + K++AR+  ++R  +L  +      
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265

Query: 828  EQSKAESMQRALEEQRK--VTAQQMAMER--AELERAKS-ALLEEQKSVMLKCGEERRRL 882
             Q +AE M++  EE  +  V AQ+ A  R  AE + A+  AL E+     ++  +E  RL
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 883  AAEWAEFSAQQKLSKERAER----EAERALQVDTQREG---TLISLAKEQAELKIRASEL 935
             AE      Q++L++E+A R    + + A Q+  + +G   TL +  + Q E+   A  L
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385

Query: 936  RAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEE----VESMSKVASEKYEEG 991
            +    +++  +A  E++ Q  R + E I     R +L  +E    V+++     +   + 
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445

Query: 992  ERALREA------QQVQAEQQARLQAVQQ------QQERLRKQEQHMHQEHLSLAQQRLQ 1039
            ER LREA      ++ + +Q+A+L  ++       QQE+L ++ Q + Q  LS     LQ
Sbjct: 2446 ER-LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504

Query: 1040 LDRARQDLPSSLVGLF 1055
             +R  +   + L  LF
Sbjct: 2505 RERFIEQEKAKLEQLF 2520



 Score =  105 bits (261), Expect = 3e-22
 Identities = 127/515 (24%), Positives = 219/515 (42%), Gaps = 69/515 (13%)

Query: 568  QVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESA 627
            QV L+ +    +AEL   +A  AE  AQ+ +             SLQ++H A  +L E A
Sbjct: 1564 QVALETAQRSAEAELQSKRASFAEKTAQLER-------------SLQEEHVAVAQLREEA 1610

Query: 628  HRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD 687
             R          Q   ER R E E    R+  +  EA + R +     Q++  A A+ + 
Sbjct: 1611 ER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664

Query: 688  QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATS-----ATSHTRSLNSIIHQ 742
            Q+ E  RE +R    + +   + +L   +L K R++   T+     A      L +   Q
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1724

Query: 743  MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQE 802
             E+    L E  +R++      +Q+R+    +  +    ++  L  + R  EE RS  ++
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1784

Query: 803  VIGKMEARLNEQSRLLEQE-RWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERA- 860
               ++EA       L E+  R R  AE++K          QR++  +  A +RAE ER  
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEEAK---------RQRQLAEEDAARQRAEAERVL 1835

Query: 861  --------KSALLEEQKSVMLKC----GEERRRLAAEWA-------EFSAQQKLSKERAE 901
                    ++  L+ +  + LK      E  RRLA + A       E +AQ K   E   
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 902  REAERALQVDTQREGTLIS-LAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLE- 959
             +  +A   + +R+  L+    +++ +++     L+A  ++ AA +A LE E   +R   
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955

Query: 960  ------KERINATALRVKLRAEEVESMSKVASEKYEEGERALREA---QQVQAEQQARLQ 1010
                  KE+    A R +  A E E   + A E+ ++   A  EA   ++   E+  RL+
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015

Query: 1011 AVQQQQERLRKQEQHMHQEHLSLAQQ----RLQLD 1041
            A  ++  RLR++ +      L LAQ+    RLQ +
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050



 Score =  103 bits (258), Expect = 7e-22
 Identities = 133/554 (24%), Positives = 245/554 (44%), Gaps = 78/554 (14%)

Query: 559  EYQKQLLAAQVQLQ---CSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLG---- 611
            + ++++LA +   +      AEL+ EL   ++   +      + ELE A+   L      
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 612  ---SLQQQHQADLELIESAHRSRIKVLE-----TSYQQREERLRRENEELSARYLSQCQE 663
                 +++ Q  L   E A R R   LE      +  +   RLR   E+ SAR L   QE
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2041

Query: 664  AEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQR-LKLLKDRE 722
            A Q R  L A+ +    A+ Q+K+QE+++  + Q  S+LD  R   E  +R  +  ++  
Sbjct: 2042 AAQKR--LQAEEKAHAFAV-QQKEQELQQTLQ-QEQSVLDQLRGEAEAARRAAEEAEEAR 2097

Query: 723  VDAATSATSHTRSLNSIIHQMEKFSSSLHE-----LSSRVEASHLTTSQERELGIRQRDE 777
            V A   A    R     + + E+   S  E       ++  A  L    E+E   R + E
Sbjct: 2098 VQAEREAAQSRRQ----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 778  QLRALQERLGQQQRDMEE--------ERSRQQEVIGKMEARLNE---QSRLLEQERWRVT 826
            Q    Q++    + +  +        ++++ ++ +  +  +L E   Q  LL++E  R+ 
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213

Query: 827  AEQSKAESMQRALEEQR---KVTAQQMAMERAELERAKSAL-----------LEEQKSVM 872
            AE ++A   +  +EE+    +V  ++++  +A +E    AL           L+E+   M
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273

Query: 873  LKCGEERRRL--AAEWA--------EFSAQQKLSKERAEREAERALQVDTQREGTLISLA 922
             +  EE  RL  AA+ A        E  AQQ+   E+  +E  +A+Q  T+ +     L 
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELL 2332

Query: 923  KEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKER-----INATALRVKLRAEEV 977
            ++Q EL    +    E+K+  A++ A E +  +  LE ER     ++A A R+KLR  E 
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE- 2391

Query: 978  ESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQ----ERLRKQEQHMHQEHLSL 1033
              MS+  +   E+ +R  ++A+++  E+  R +   Q++    + L  Q Q    +   L
Sbjct: 2392 --MSRAQARAEEDAQRFRKQAEEI-GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448

Query: 1034 AQQRLQLDRARQDL 1047
             +   +L+R ++ L
Sbjct: 2449 REAIAELEREKEKL 2462



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 140/533 (26%), Positives = 239/533 (44%), Gaps = 74/533 (13%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            QK L  A+ + Q   AE +A         A  + ++ + ELE+ Q +L  G+ QQ+  A+
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAE 1712

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLA 680
             ELI    R+  +  E   Q  EE L R   E +A    + QE E   A++ A+ +  LA
Sbjct: 1713 QELIRL--RAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLA 1769

Query: 681  AIAQEKDQEMERLRELQRASILDMRRDHE--EQLQRLKLLKDR--------EVDAATSAT 730
            + A+ +++      + ++    +  R  E  E+  RL+ L +         E DAA    
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829

Query: 731  SHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRD---EQLRALQERLG 787
               R L               +L++  EA+ L T  E E+ +++++   E+LR L E   
Sbjct: 1830 EAERVL-------------AEKLAAIGEATRLKT--EAEIALKEKEAENERLRRLAEDEA 1874

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ---RK 844
             Q+R +EE+ ++ +  I +  A+L + S   E ER +   E +  +  +R +EE+    K
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDS-ELERQKGLVEDTLRQ--RRQVEEEILALK 1931

Query: 845  VTAQQMAMERAELE--------------RAKS-ALLEEQKSVMLKCGEERRR-------- 881
             + ++ A  +AELE              R+K  A LE  +   L   EERRR        
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991

Query: 882  --LAAEWAEFSAQQKLSKERAER------EAERALQVDTQREGTLISLAKEQAELKIRAS 933
              LAAE  E + Q+K + E  ER      EA R  +   Q     + LA+E A+ +++A 
Sbjct: 1992 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050

Query: 934  ELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGER 993
            E +A    +  +   L+Q  Q+ +   +++   A   +  AEE E     A  +  +  R
Sbjct: 2051 E-KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109

Query: 994  ALREAQQVQ--AEQQARLQA-VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRA 1043
             + EA++++  AE+QA+ +A  Q   E+LRK+ +          Q  L+  +A
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 149/642 (23%), Positives = 264/642 (41%), Gaps = 160/642 (24%)

Query: 559  EYQKQLLAAQVQLQCSPAE--LQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ 616
            E  +Q  A Q+QL    A+  LQAE    +A    ++ + ++L+    Q + +L  L+ +
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082

Query: 617  HQADLELIESAHRSRIKVLETSYQQRE-----ERLRRENEELS-ARYLSQC------QEA 664
             +A     E A  +R++    + Q R      ERL++  EE + AR  +Q       +EA
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142

Query: 665  EQ-----ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASI--------LDMRR-DHEE 710
            EQ     A+AE  A  Q++ A    EK ++       Q+A +        L +   DH++
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202

Query: 711  QL--QRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             L  + L+ LK    +AA   +     L S+  QME+ S    +L +R+EA      + R
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS----KLKARIEA------ENR 2252

Query: 769  ELGIRQRDEQLRALQERLGQQQ-------------------RDMEEERSRQQEVIG---- 805
             L +R +D   R LQE   + +                   R + EE   QQ  +     
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312

Query: 806  --KMEA-----RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELE 858
              KM+A     RL  ++ LL+Q++         A+   R L+E ++  AQQ+A E    +
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQK-------ELAQEQARRLQEDKEQMAQQLAEETQGFQ 2365

Query: 859  RAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVD------- 911
            R     LE ++   L+   E  RL    AE S  Q  ++E A+R  ++A ++        
Sbjct: 2366 RT----LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421

Query: 912  --TQREGTLISLA------------------------KEQAELKIRASELRAEEKQ---- 941
              TQ + TL+                           KE+ + + +  +L++EE Q    
Sbjct: 2422 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481

Query: 942  ---------------------------LAAERAALEQ-------ERQELRLEKERINATA 967
                                       +  E+A LEQ       + Q+LR E++R     
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 968  LRVKLRAEEVESMSKVASEKYEEGE---RALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024
             + + R   V SM +    ++E  E   R   E QQ++ +++ + + + ++ +RLR+Q Q
Sbjct: 2542 EQERQRL--VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599

Query: 1025 HMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQ 1066
             + ++H +      ++  ++     +L        GPAA ++
Sbjct: 2600 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2641



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 125/546 (22%), Positives = 243/546 (44%), Gaps = 76/546 (13%)

Query: 560  YQKQLLAAQV------QLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSL 613
            +++QL  AQ       +L+ + A L+   L +QA   +      + EL  AQ    +G  
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKK--LRAQAEAQQPTFDALRDELRGAQE---VGER 1162

Query: 614  QQQHQADLELIESAHRSRIKVL---------ETSYQQRE-ERLRRE-------NEELSA- 655
             QQ   + ++     R R+  L         +T  +QRE E+L R+        + L A 
Sbjct: 1163 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1222

Query: 656  -----RYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRAS--ILDMRRDH 708
                 R   Q Q    A ++   +  R+  A+ +E ++  E++ E QR +   ++  +D+
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282

Query: 709  EEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
            E QL   K   +     A      + S  S+I +     +   EL++        TSQ  
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTT-------LTSQY- 1333

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAE 828
               I+   E LR ++E    ++R  E++R+ ++E + ++EA L +Q +L E         
Sbjct: 1334 ---IKFISETLRRMEE----EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1386

Query: 829  QSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEE--QKSVMLKCGEERRRLAAEW 886
            + +A+ +Q+ ++E+  V  ++ A++  + +R+    L++  Q S      + R+  AAE 
Sbjct: 1387 EREAKELQQRMQEE-VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAE-------- 938
            +    ++++   R + EA    +   + E   +    E+AE + R ++  AE        
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505

Query: 939  ----EKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVAS-EKYEEGER 993
                ++Q   E A+  +   E   EK+R       ++L+AEE E   + A  E+  + + 
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1565

Query: 994  ALREAQQ-VQAEQQARLQAVQQQQERLRK--QEQHMH-----QEHLSLAQQRLQLDRARQ 1045
            AL  AQ+  +AE Q++  +  ++  +L +  QE+H+      +E    AQQ+ + +RAR+
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625

Query: 1046 DLPSSL 1051
            +    L
Sbjct: 1626 EAEREL 1631



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 93/427 (21%), Positives = 162/427 (37%), Gaps = 71/427 (16%)

Query: 662  QEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDR 721
            QEA++A   L AQHQ  L  +  +   +M+ L   Q      +RRD       ++L+  R
Sbjct: 863  QEAQEAVTRLEAQHQA-LVTLWHQLHVDMKSLLAWQ-----SLRRD-------VQLI--R 907

Query: 722  EVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRA 781
                AT  T         +H +E    +   L    +A      ++R +  R+       
Sbjct: 908  SWSLATFRTLKPEEQRQALHSLELHYQAF--LRDSQDAGGFGP-EDRLMAEREYGSCSHH 964

Query: 782  LQERLGQQQRDMEEERSRQQEVIGKMEARLN-EQSRLLEQERWRVTAEQSKAESMQRALE 840
             Q+ L   ++  +EE   Q+ +    + RL  E        R R+  ++  A    + + 
Sbjct: 965  YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1024

Query: 841  EQRKVTAQQMAMER------AELERA--------KSALLEEQKSVMLKCGEERRRLAAEW 886
            EQ+K  A+   + +      AE E+          +  L  +  + L   E+ R L+A +
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1084

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQR--------------EGTLISLAKEQAELKIR- 931
             E      L   R  + AE  L+   ++              E T  SL K +A+ + + 
Sbjct: 1085 LEKLKTISLVI-RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143

Query: 932  ------------ASELRAEEKQLAAER-AALEQERQELRLEKERINATALRVKLRAEEVE 978
                        A E+    +Q   ER   +E+ R+ +    ER  A   +  +R  E+E
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1203

Query: 979  SMSKVASEKYEEG-------ERALREAQQVQAEQQARLQAVQQQ--QERLRKQEQHMHQE 1029
             + +      E         + A R  +Q+QA   A  QAV++Q  QE+   +E   H E
Sbjct: 1204 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1263

Query: 1030 HLSLAQQ 1036
             +   Q+
Sbjct: 1264 KVEECQR 1270


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  110 bits (276), Expect = 6e-24
 Identities = 142/589 (24%), Positives = 258/589 (43%), Gaps = 88/589 (14%)

Query: 559  EYQKQLLAAQVQLQCSPA----ELQAELLHSQARLAE--LEAQVRKLELERAQHELLLGS 612
            E Q+QL  A  Q +        ELQ  +     R  E  ++AQ +K  ++    +L   S
Sbjct: 1338 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1397

Query: 613  LQQQHQADLELIESAHRSRIKV----------LETSYQQRE------ERLRRENEELSAR 656
             + + QA     E+A RSR+++          LE + +QR       + LR   EE  A+
Sbjct: 1398 -EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1456

Query: 657  YLSQCQEAEQARAELTAQHQRRLAA---IAQEKDQEMERLRELQRA--SILDMRRDHEEQ 711
                 +EAE+ R ++  + QR+  A   +A     E E  RE QRA  ++ ++R   EE 
Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1516

Query: 712  LQRLK---LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             +RL+   + + R+V  A   T+   +   +  +   F+    +L   ++  H+  +Q R
Sbjct: 1517 ERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1575

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIG-KMEARLNEQSRLLEQERWRVTA 827
            E   R+  +Q  A + R  + +R++E  + +  E +  +++A    Q + L Q       
Sbjct: 1576 EEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634

Query: 828  EQSKAESMQRALEEQRKVTAQQMAMERAELER------AKSALLEEQKSVMLKC----GE 877
            E+++ E+ +R   E++ V  +++A +  E +R      A+  L  EQ+ + L+     GE
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694

Query: 878  ERRRL----------------------AAEWAEFSAQQKL---SKERAEREAERALQVDT 912
            ++R+L                       AE A+  A+ ++   SK RAE E+    +   
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1754

Query: 913  QR----EGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATAL 968
            QR     G    LA+E A L+  A E +  ++QLA E AA +      R E ER+ A  L
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAK-RQRQLAEEDAARQ------RAEAERVLAEKL 1807

Query: 969  RVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQA--------VQQQQERLR 1020
                 A  +++ +++A ++ E     LR   + +A Q+ RL+         ++++  +LR
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867

Query: 1021 KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSAL 1069
            K      +    L +  L+  R  ++   +L   F +A    A  +  L
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1916



 Score =  108 bits (270), Expect = 3e-23
 Identities = 127/512 (24%), Positives = 231/512 (45%), Gaps = 62/512 (12%)

Query: 568  QVQLQCSP-AELQA---ELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ------H 617
            Q Q+Q  P A+ QA   +L   QA L E+E    K+E  +   +  + +++        +
Sbjct: 1198 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1257

Query: 618  QADLELIES-AHRSRIKVLETSYQQREERLRRENEELS----------ARYLSQCQEAEQ 666
            +A LE + S A + +++    S  Q    LR    EL+          +  L + +E E+
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317

Query: 667  ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAA 726
               +  A+ + RLA +    +++ + L E    +     R+ +E  QR++    R  +AA
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1376

Query: 727  TSATSHTRSLNSIIHQMEKFSSSLHELSSR----VEASHLTTSQERELGIRQRDEQLRAL 782
              A    RS+   + Q+ + S +  +  +R     E S L   +E    IR    QL A 
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE----IRVVRLQLEAT 1432

Query: 783  QERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ 842
            + + G  + +++  R+R +      EA   ++    E ER R   +       Q  +E  
Sbjct: 1433 ERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1486

Query: 843  RKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAER 902
             +V A+      AE  R K   L+  + + L+  E  RRL     E + Q +++ E A+R
Sbjct: 1487 SRVKAE------AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1540

Query: 903  EAERALQVDTQREGTLISLAKEQAELK-------IRASELRAEEKQLAAERAALEQERQE 955
             AE  LQ          S A++ A+L+       +  ++LR E ++ A ++A  E+ R+E
Sbjct: 1541 SAEAELQ------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1594

Query: 956  LRLEKERINA---TALRVKLRAEEV---ESMSKVASEKY-EEGERALREAQQVQAEQQAR 1008
               E ER       ALR++L+AEEV   +S+++  +EK  EE ER  R   + + +   +
Sbjct: 1595 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1654

Query: 1009 LQAVQQQQERLRKQEQHMHQEHLSLAQQRLQL 1040
             +  +Q+ E+ R+  +   Q+ L+  Q+ ++L
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1686



 Score =  106 bits (264), Expect = 1e-22
 Identities = 135/556 (24%), Positives = 256/556 (46%), Gaps = 56/556 (10%)

Query: 551  ARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLL 610
            AR    + E +++   A+ ++Q S A  +      +A L E+E    K+E  R   E   
Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 1994

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSY----QQREERLRRENEELSARYLSQCQEAEQ 666
               +Q+    L+L + A + R++  E ++    QQ+E+ L++  ++  +       EAE 
Sbjct: 1995 -RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2053

Query: 667  ARAELTAQHQRRLAA--IAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVD 724
            AR       + R+ A   A +  +++E    L++++    +   + Q    KL K+ E +
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2113

Query: 725  AATSATSHTRSL------NSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR--- 775
            AA  A +   +L      ++ + + +KF+       ++VE    T   + E    Q+   
Sbjct: 2114 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2173

Query: 776  DEQLRALQ---ERLGQQQRDMEEERSR---QQEVIGKMEARLNEQSR--LLEQERWRVTA 827
            DE+L+ L+       +Q+  +EEE      Q E + K++AR+  ++R  +L  +      
Sbjct: 2174 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2233

Query: 828  EQSKAESMQRALEEQRK--VTAQQMAMER--AELERAKS-ALLEEQKSVMLKCGEERRRL 882
             Q +AE M++  EE  +  V AQ+ A  R  AE + A+  AL E+     ++  +E  RL
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293

Query: 883  AAEWAEFSAQQKLSKERAER----EAERALQVDTQREG---TLISLAKEQAELKIRASEL 935
             AE      Q++L++E+A R    + + A Q+  + +G   TL +  + Q E+   A  L
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353

Query: 936  RAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEE----VESMSKVASEKYEEG 991
            +    +++  +A  E++ Q  R + E I     R +L  +E    V+++     +   + 
Sbjct: 2354 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2413

Query: 992  ERALREA------QQVQAEQQARLQAVQQ------QQERLRKQEQHMHQEHLSLAQQRLQ 1039
            ER LREA      ++ + +Q+A+L  ++       QQE+L ++ Q + Q  LS     LQ
Sbjct: 2414 ER-LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472

Query: 1040 LDRARQDLPSSLVGLF 1055
             +R  +   + L  LF
Sbjct: 2473 RERFIEQEKAKLEQLF 2488



 Score =  105 bits (261), Expect = 3e-22
 Identities = 127/515 (24%), Positives = 219/515 (42%), Gaps = 69/515 (13%)

Query: 568  QVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESA 627
            QV L+ +    +AEL   +A  AE  AQ+ +             SLQ++H A  +L E A
Sbjct: 1532 QVALETAQRSAEAELQSKRASFAEKTAQLER-------------SLQEEHVAVAQLREEA 1578

Query: 628  HRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD 687
             R          Q   ER R E E    R+  +  EA + R +     Q++  A A+ + 
Sbjct: 1579 ER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1632

Query: 688  QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATS-----ATSHTRSLNSIIHQ 742
            Q+ E  RE +R    + +   + +L   +L K R++   T+     A      L +   Q
Sbjct: 1633 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1692

Query: 743  MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQE 802
             E+    L E  +R++      +Q+R+    +  +    ++  L  + R  EE RS  ++
Sbjct: 1693 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1752

Query: 803  VIGKMEARLNEQSRLLEQE-RWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERA- 860
               ++EA       L E+  R R  AE++K          QR++  +  A +RAE ER  
Sbjct: 1753 SKQRLEAEAGRFRELAEEAARLRALAEEAK---------RQRQLAEEDAARQRAEAERVL 1803

Query: 861  --------KSALLEEQKSVMLKC----GEERRRLAAEWA-------EFSAQQKLSKERAE 901
                    ++  L+ +  + LK      E  RRLA + A       E +AQ K   E   
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863

Query: 902  REAERALQVDTQREGTLIS-LAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLE- 959
             +  +A   + +R+  L+    +++ +++     L+A  ++ AA +A LE E   +R   
Sbjct: 1864 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1923

Query: 960  ------KERINATALRVKLRAEEVESMSKVASEKYEEGERALREA---QQVQAEQQARLQ 1010
                  KE+    A R +  A E E   + A E+ ++   A  EA   ++   E+  RL+
Sbjct: 1924 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1983

Query: 1011 AVQQQQERLRKQEQHMHQEHLSLAQQ----RLQLD 1041
            A  ++  RLR++ +      L LAQ+    RLQ +
Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018



 Score =  103 bits (258), Expect = 7e-22
 Identities = 133/554 (24%), Positives = 245/554 (44%), Gaps = 78/554 (14%)

Query: 559  EYQKQLLAAQVQLQ---CSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLG---- 611
            + ++++LA +   +      AEL+ EL   ++   +      + ELE A+   L      
Sbjct: 1890 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1949

Query: 612  ---SLQQQHQADLELIESAHRSRIKVLE-----TSYQQREERLRRENEELSARYLSQCQE 663
                 +++ Q  L   E A R R   LE      +  +   RLR   E+ SAR L   QE
Sbjct: 1950 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2009

Query: 664  AEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQR-LKLLKDRE 722
            A Q R  L A+ +    A+ Q+K+QE+++  + Q  S+LD  R   E  +R  +  ++  
Sbjct: 2010 AAQKR--LQAEEKAHAFAV-QQKEQELQQTLQ-QEQSVLDQLRGEAEAARRAAEEAEEAR 2065

Query: 723  VDAATSATSHTRSLNSIIHQMEKFSSSLHE-----LSSRVEASHLTTSQERELGIRQRDE 777
            V A   A    R     + + E+   S  E       ++  A  L    E+E   R + E
Sbjct: 2066 VQAEREAAQSRRQ----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2121

Query: 778  QLRALQERLGQQQRDMEE--------ERSRQQEVIGKMEARLNE---QSRLLEQERWRVT 826
            Q    Q++    + +  +        ++++ ++ +  +  +L E   Q  LL++E  R+ 
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2181

Query: 827  AEQSKAESMQRALEEQR---KVTAQQMAMERAELERAKSAL-----------LEEQKSVM 872
            AE ++A   +  +EE+    +V  ++++  +A +E    AL           L+E+   M
Sbjct: 2182 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2241

Query: 873  LKCGEERRRL--AAEWA--------EFSAQQKLSKERAEREAERALQVDTQREGTLISLA 922
             +  EE  RL  AA+ A        E  AQQ+   E+  +E  +A+Q  T+ +     L 
Sbjct: 2242 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELL 2300

Query: 923  KEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKER-----INATALRVKLRAEEV 977
            ++Q EL    +    E+K+  A++ A E +  +  LE ER     ++A A R+KLR  E 
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE- 2359

Query: 978  ESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQ----ERLRKQEQHMHQEHLSL 1033
              MS+  +   E+ +R  ++A+++  E+  R +   Q++    + L  Q Q    +   L
Sbjct: 2360 --MSRAQARAEEDAQRFRKQAEEI-GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2416

Query: 1034 AQQRLQLDRARQDL 1047
             +   +L+R ++ L
Sbjct: 2417 REAIAELEREKEKL 2430



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 140/533 (26%), Positives = 239/533 (44%), Gaps = 74/533 (13%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            QK L  A+ + Q   AE +A         A  + ++ + ELE+ Q +L  G+ QQ+  A+
Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAE 1680

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLA 680
             ELI    R+  +  E   Q  EE L R   E +A    + QE E   A++ A+ +  LA
Sbjct: 1681 QELIRL--RAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLA 1737

Query: 681  AIAQEKDQEMERLRELQRASILDMRRDHE--EQLQRLKLLKDR--------EVDAATSAT 730
            + A+ +++      + ++    +  R  E  E+  RL+ L +         E DAA    
Sbjct: 1738 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1797

Query: 731  SHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRD---EQLRALQERLG 787
               R L               +L++  EA+ L T  E E+ +++++   E+LR L E   
Sbjct: 1798 EAERVL-------------AEKLAAIGEATRLKT--EAEIALKEKEAENERLRRLAEDEA 1842

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ---RK 844
             Q+R +EE+ ++ +  I +  A+L + S   E ER +   E +  +  +R +EE+    K
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDS-ELERQKGLVEDTLRQ--RRQVEEEILALK 1899

Query: 845  VTAQQMAMERAELE--------------RAKS-ALLEEQKSVMLKCGEERRR-------- 881
             + ++ A  +AELE              R+K  A LE  +   L   EERRR        
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1959

Query: 882  --LAAEWAEFSAQQKLSKERAER------EAERALQVDTQREGTLISLAKEQAELKIRAS 933
              LAAE  E + Q+K + E  ER      EA R  +   Q     + LA+E A+ +++A 
Sbjct: 1960 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018

Query: 934  ELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGER 993
            E +A    +  +   L+Q  Q+ +   +++   A   +  AEE E     A  +  +  R
Sbjct: 2019 E-KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2077

Query: 994  ALREAQQVQ--AEQQARLQA-VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRA 1043
             + EA++++  AE+QA+ +A  Q   E+LRK+ +          Q  L+  +A
Sbjct: 2078 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2130



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 149/642 (23%), Positives = 264/642 (41%), Gaps = 160/642 (24%)

Query: 559  EYQKQLLAAQVQLQCSPAE--LQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ 616
            E  +Q  A Q+QL    A+  LQAE    +A    ++ + ++L+    Q + +L  L+ +
Sbjct: 1994 ERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2050

Query: 617  HQADLELIESAHRSRIKVLETSYQQRE-----ERLRRENEELS-ARYLSQC------QEA 664
             +A     E A  +R++    + Q R      ERL++  EE + AR  +Q       +EA
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2110

Query: 665  EQ-----ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASI--------LDMRR-DHEE 710
            EQ     A+AE  A  Q++ A    EK ++       Q+A +        L +   DH++
Sbjct: 2111 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2170

Query: 711  QL--QRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             L  + L+ LK    +AA   +     L S+  QME+ S    +L +R+EA      + R
Sbjct: 2171 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS----KLKARIEA------ENR 2220

Query: 769  ELGIRQRDEQLRALQERLGQQQ-------------------RDMEEERSRQQEVIG---- 805
             L +R +D   R LQE   + +                   R + EE   QQ  +     
Sbjct: 2221 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2280

Query: 806  --KMEA-----RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELE 858
              KM+A     RL  ++ LL+Q++         A+   R L+E ++  AQQ+A E    +
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQK-------ELAQEQARRLQEDKEQMAQQLAEETQGFQ 2333

Query: 859  RAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVD------- 911
            R     LE ++   L+   E  RL    AE S  Q  ++E A+R  ++A ++        
Sbjct: 2334 RT----LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2389

Query: 912  --TQREGTLISLA------------------------KEQAELKIRASELRAEEKQ---- 941
              TQ + TL+                           KE+ + + +  +L++EE Q    
Sbjct: 2390 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2449

Query: 942  ---------------------------LAAERAALEQ-------ERQELRLEKERINATA 967
                                       +  E+A LEQ       + Q+LR E++R     
Sbjct: 2450 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2509

Query: 968  LRVKLRAEEVESMSKVASEKYEEGE---RALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024
             + + R   V SM +    ++E  E   R   E QQ++ +++ + + + ++ +RLR+Q Q
Sbjct: 2510 EQERQRL--VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567

Query: 1025 HMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQ 1066
             + ++H +      ++  ++     +L        GPAA ++
Sbjct: 2568 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2609



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 125/546 (22%), Positives = 243/546 (44%), Gaps = 76/546 (13%)

Query: 560  YQKQLLAAQV------QLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSL 613
            +++QL  AQ       +L+ + A L+   L +QA   +      + EL  AQ    +G  
Sbjct: 1076 HEEQLKEAQAVPATLPELEATKASLKK--LRAQAEAQQPTFDALRDELRGAQE---VGER 1130

Query: 614  QQQHQADLELIESAHRSRIKVL---------ETSYQQRE-ERLRRE-------NEELSA- 655
             QQ   + ++     R R+  L         +T  +QRE E+L R+        + L A 
Sbjct: 1131 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1190

Query: 656  -----RYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRAS--ILDMRRDH 708
                 R   Q Q    A ++   +  R+  A+ +E ++  E++ E QR +   ++  +D+
Sbjct: 1191 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1250

Query: 709  EEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
            E QL   K   +     A      + S  S+I +     +   EL++        TSQ  
Sbjct: 1251 ELQLVTYKAQLEPVASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTT-------LTSQY- 1301

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAE 828
               I+   E LR ++E    ++R  E++R+ ++E + ++EA L +Q +L E         
Sbjct: 1302 ---IKFISETLRRMEE----EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1354

Query: 829  QSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEE--QKSVMLKCGEERRRLAAEW 886
            + +A+ +Q+ ++E+  V  ++ A++  + +R+    L++  Q S      + R+  AAE 
Sbjct: 1355 EREAKELQQRMQEE-VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1413

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAE-------- 938
            +    ++++   R + EA    +   + E   +    E+AE + R ++  AE        
Sbjct: 1414 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1473

Query: 939  ----EKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVAS-EKYEEGER 993
                ++Q   E A+  +   E   EK+R       ++L+AEE E   + A  E+  + + 
Sbjct: 1474 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1533

Query: 994  ALREAQQ-VQAEQQARLQAVQQQQERLRK--QEQHMH-----QEHLSLAQQRLQLDRARQ 1045
            AL  AQ+  +AE Q++  +  ++  +L +  QE+H+      +E    AQQ+ + +RAR+
Sbjct: 1534 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1593

Query: 1046 DLPSSL 1051
            +    L
Sbjct: 1594 EAEREL 1599



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 93/427 (21%), Positives = 162/427 (37%), Gaps = 71/427 (16%)

Query: 662  QEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDR 721
            QEA++A   L AQHQ  L  +  +   +M+ L   Q      +RRD       ++L+  R
Sbjct: 831  QEAQEAVTRLEAQHQA-LVTLWHQLHVDMKSLLAWQ-----SLRRD-------VQLI--R 875

Query: 722  EVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRA 781
                AT  T         +H +E    +   L    +A      ++R +  R+       
Sbjct: 876  SWSLATFRTLKPEEQRQALHSLELHYQAF--LRDSQDAGGFGP-EDRLMAEREYGSCSHH 932

Query: 782  LQERLGQQQRDMEEERSRQQEVIGKMEARLN-EQSRLLEQERWRVTAEQSKAESMQRALE 840
             Q+ L   ++  +EE   Q+ +    + RL  E        R R+  ++  A    + + 
Sbjct: 933  YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 992

Query: 841  EQRKVTAQQMAMER------AELERA--------KSALLEEQKSVMLKCGEERRRLAAEW 886
            EQ+K  A+   + +      AE E+          +  L  +  + L   E+ R L+A +
Sbjct: 993  EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1052

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQR--------------EGTLISLAKEQAELKIR- 931
             E      L   R  + AE  L+   ++              E T  SL K +A+ + + 
Sbjct: 1053 LEKLKTISLVI-RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1111

Query: 932  ------------ASELRAEEKQLAAER-AALEQERQELRLEKERINATALRVKLRAEEVE 978
                        A E+    +Q   ER   +E+ R+ +    ER  A   +  +R  E+E
Sbjct: 1112 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1171

Query: 979  SMSKVASEKYEEG-------ERALREAQQVQAEQQARLQAVQQQ--QERLRKQEQHMHQE 1029
             + +      E         + A R  +Q+QA   A  QAV++Q  QE+   +E   H E
Sbjct: 1172 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1231

Query: 1030 HLSLAQQ 1036
             +   Q+
Sbjct: 1232 KVEECQR 1238


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  110 bits (276), Expect = 6e-24
 Identities = 142/589 (24%), Positives = 258/589 (43%), Gaps = 88/589 (14%)

Query: 559  EYQKQLLAAQVQLQCSPA----ELQAELLHSQARLAE--LEAQVRKLELERAQHELLLGS 612
            E Q+QL  A  Q +        ELQ  +     R  E  ++AQ +K  ++    +L   S
Sbjct: 1507 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1566

Query: 613  LQQQHQADLELIESAHRSRIKV----------LETSYQQRE------ERLRRENEELSAR 656
             + + QA     E+A RSR+++          LE + +QR       + LR   EE  A+
Sbjct: 1567 -EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1625

Query: 657  YLSQCQEAEQARAELTAQHQRRLAA---IAQEKDQEMERLRELQRA--SILDMRRDHEEQ 711
                 +EAE+ R ++  + QR+  A   +A     E E  RE QRA  ++ ++R   EE 
Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1685

Query: 712  LQRLK---LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             +RL+   + + R+V  A   T+   +   +  +   F+    +L   ++  H+  +Q R
Sbjct: 1686 ERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1744

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIG-KMEARLNEQSRLLEQERWRVTA 827
            E   R+  +Q  A + R  + +R++E  + +  E +  +++A    Q + L Q       
Sbjct: 1745 EEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803

Query: 828  EQSKAESMQRALEEQRKVTAQQMAMERAELER------AKSALLEEQKSVMLKC----GE 877
            E+++ E+ +R   E++ V  +++A +  E +R      A+  L  EQ+ + L+     GE
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863

Query: 878  ERRRL----------------------AAEWAEFSAQQKL---SKERAEREAERALQVDT 912
            ++R+L                       AE A+  A+ ++   SK RAE E+    +   
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923

Query: 913  QR----EGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATAL 968
            QR     G    LA+E A L+  A E +  ++QLA E AA +      R E ER+ A  L
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAK-RQRQLAEEDAARQ------RAEAERVLAEKL 1976

Query: 969  RVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQA--------VQQQQERLR 1020
                 A  +++ +++A ++ E     LR   + +A Q+ RL+         ++++  +LR
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036

Query: 1021 KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSAL 1069
            K      +    L +  L+  R  ++   +L   F +A    A  +  L
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 2085



 Score =  108 bits (270), Expect = 3e-23
 Identities = 127/512 (24%), Positives = 231/512 (45%), Gaps = 62/512 (12%)

Query: 568  QVQLQCSP-AELQA---ELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ------H 617
            Q Q+Q  P A+ QA   +L   QA L E+E    K+E  +   +  + +++        +
Sbjct: 1367 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1426

Query: 618  QADLELIES-AHRSRIKVLETSYQQREERLRRENEELS----------ARYLSQCQEAEQ 666
            +A LE + S A + +++    S  Q    LR    EL+          +  L + +E E+
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486

Query: 667  ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAA 726
               +  A+ + RLA +    +++ + L E    +     R+ +E  QR++    R  +AA
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545

Query: 727  TSATSHTRSLNSIIHQMEKFSSSLHELSSR----VEASHLTTSQERELGIRQRDEQLRAL 782
              A    RS+   + Q+ + S +  +  +R     E S L   +E    IR    QL A 
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE----IRVVRLQLEAT 1601

Query: 783  QERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ 842
            + + G  + +++  R+R +      EA   ++    E ER R   +       Q  +E  
Sbjct: 1602 ERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655

Query: 843  RKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAER 902
             +V A+      AE  R K   L+  + + L+  E  RRL     E + Q +++ E A+R
Sbjct: 1656 SRVKAE------AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1709

Query: 903  EAERALQVDTQREGTLISLAKEQAELK-------IRASELRAEEKQLAAERAALEQERQE 955
             AE  LQ          S A++ A+L+       +  ++LR E ++ A ++A  E+ R+E
Sbjct: 1710 SAEAELQ------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1763

Query: 956  LRLEKERINA---TALRVKLRAEEV---ESMSKVASEKY-EEGERALREAQQVQAEQQAR 1008
               E ER       ALR++L+AEEV   +S+++  +EK  EE ER  R   + + +   +
Sbjct: 1764 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1823

Query: 1009 LQAVQQQQERLRKQEQHMHQEHLSLAQQRLQL 1040
             +  +Q+ E+ R+  +   Q+ L+  Q+ ++L
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1855



 Score =  106 bits (264), Expect = 1e-22
 Identities = 135/556 (24%), Positives = 256/556 (46%), Gaps = 56/556 (10%)

Query: 551  ARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLL 610
            AR    + E +++   A+ ++Q S A  +      +A L E+E    K+E  R   E   
Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2163

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSY----QQREERLRRENEELSARYLSQCQEAEQ 666
               +Q+    L+L + A + R++  E ++    QQ+E+ L++  ++  +       EAE 
Sbjct: 2164 -RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2222

Query: 667  ARAELTAQHQRRLAA--IAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVD 724
            AR       + R+ A   A +  +++E    L++++    +   + Q    KL K+ E +
Sbjct: 2223 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2282

Query: 725  AATSATSHTRSL------NSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR--- 775
            AA  A +   +L      ++ + + +KF+       ++VE    T   + E    Q+   
Sbjct: 2283 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342

Query: 776  DEQLRALQ---ERLGQQQRDMEEERSR---QQEVIGKMEARLNEQSR--LLEQERWRVTA 827
            DE+L+ L+       +Q+  +EEE      Q E + K++AR+  ++R  +L  +      
Sbjct: 2343 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2402

Query: 828  EQSKAESMQRALEEQRK--VTAQQMAMER--AELERAKS-ALLEEQKSVMLKCGEERRRL 882
             Q +AE M++  EE  +  V AQ+ A  R  AE + A+  AL E+     ++  +E  RL
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462

Query: 883  AAEWAEFSAQQKLSKERAER----EAERALQVDTQREG---TLISLAKEQAELKIRASEL 935
             AE      Q++L++E+A R    + + A Q+  + +G   TL +  + Q E+   A  L
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522

Query: 936  RAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEE----VESMSKVASEKYEEG 991
            +    +++  +A  E++ Q  R + E I     R +L  +E    V+++     +   + 
Sbjct: 2523 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2582

Query: 992  ERALREA------QQVQAEQQARLQAVQQ------QQERLRKQEQHMHQEHLSLAQQRLQ 1039
            ER LREA      ++ + +Q+A+L  ++       QQE+L ++ Q + Q  LS     LQ
Sbjct: 2583 ER-LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641

Query: 1040 LDRARQDLPSSLVGLF 1055
             +R  +   + L  LF
Sbjct: 2642 RERFIEQEKAKLEQLF 2657



 Score =  105 bits (261), Expect = 3e-22
 Identities = 127/515 (24%), Positives = 219/515 (42%), Gaps = 69/515 (13%)

Query: 568  QVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESA 627
            QV L+ +    +AEL   +A  AE  AQ+ +             SLQ++H A  +L E A
Sbjct: 1701 QVALETAQRSAEAELQSKRASFAEKTAQLER-------------SLQEEHVAVAQLREEA 1747

Query: 628  HRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD 687
             R          Q   ER R E E    R+  +  EA + R +     Q++  A A+ + 
Sbjct: 1748 ER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1801

Query: 688  QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATS-----ATSHTRSLNSIIHQ 742
            Q+ E  RE +R    + +   + +L   +L K R++   T+     A      L +   Q
Sbjct: 1802 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1861

Query: 743  MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQE 802
             E+    L E  +R++      +Q+R+    +  +    ++  L  + R  EE RS  ++
Sbjct: 1862 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1921

Query: 803  VIGKMEARLNEQSRLLEQE-RWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERA- 860
               ++EA       L E+  R R  AE++K          QR++  +  A +RAE ER  
Sbjct: 1922 SKQRLEAEAGRFRELAEEAARLRALAEEAK---------RQRQLAEEDAARQRAEAERVL 1972

Query: 861  --------KSALLEEQKSVMLKC----GEERRRLAAEWA-------EFSAQQKLSKERAE 901
                    ++  L+ +  + LK      E  RRLA + A       E +AQ K   E   
Sbjct: 1973 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032

Query: 902  REAERALQVDTQREGTLIS-LAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLE- 959
             +  +A   + +R+  L+    +++ +++     L+A  ++ AA +A LE E   +R   
Sbjct: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 2092

Query: 960  ------KERINATALRVKLRAEEVESMSKVASEKYEEGERALREA---QQVQAEQQARLQ 1010
                  KE+    A R +  A E E   + A E+ ++   A  EA   ++   E+  RL+
Sbjct: 2093 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2152

Query: 1011 AVQQQQERLRKQEQHMHQEHLSLAQQ----RLQLD 1041
            A  ++  RLR++ +      L LAQ+    RLQ +
Sbjct: 2153 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187



 Score =  103 bits (258), Expect = 7e-22
 Identities = 133/554 (24%), Positives = 245/554 (44%), Gaps = 78/554 (14%)

Query: 559  EYQKQLLAAQVQLQ---CSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLG---- 611
            + ++++LA +   +      AEL+ EL   ++   +      + ELE A+   L      
Sbjct: 2059 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2118

Query: 612  ---SLQQQHQADLELIESAHRSRIKVLE-----TSYQQREERLRRENEELSARYLSQCQE 663
                 +++ Q  L   E A R R   LE      +  +   RLR   E+ SAR L   QE
Sbjct: 2119 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2178

Query: 664  AEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQR-LKLLKDRE 722
            A Q R  L A+ +    A+ Q+K+QE+++  + Q  S+LD  R   E  +R  +  ++  
Sbjct: 2179 AAQKR--LQAEEKAHAFAV-QQKEQELQQTLQ-QEQSVLDQLRGEAEAARRAAEEAEEAR 2234

Query: 723  VDAATSATSHTRSLNSIIHQMEKFSSSLHE-----LSSRVEASHLTTSQERELGIRQRDE 777
            V A   A    R     + + E+   S  E       ++  A  L    E+E   R + E
Sbjct: 2235 VQAEREAAQSRRQ----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2290

Query: 778  QLRALQERLGQQQRDMEE--------ERSRQQEVIGKMEARLNE---QSRLLEQERWRVT 826
            Q    Q++    + +  +        ++++ ++ +  +  +L E   Q  LL++E  R+ 
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2350

Query: 827  AEQSKAESMQRALEEQR---KVTAQQMAMERAELERAKSAL-----------LEEQKSVM 872
            AE ++A   +  +EE+    +V  ++++  +A +E    AL           L+E+   M
Sbjct: 2351 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2410

Query: 873  LKCGEERRRL--AAEWA--------EFSAQQKLSKERAEREAERALQVDTQREGTLISLA 922
             +  EE  RL  AA+ A        E  AQQ+   E+  +E  +A+Q  T+ +     L 
Sbjct: 2411 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELL 2469

Query: 923  KEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKER-----INATALRVKLRAEEV 977
            ++Q EL    +    E+K+  A++ A E +  +  LE ER     ++A A R+KLR  E 
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE- 2528

Query: 978  ESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQ----ERLRKQEQHMHQEHLSL 1033
              MS+  +   E+ +R  ++A+++  E+  R +   Q++    + L  Q Q    +   L
Sbjct: 2529 --MSRAQARAEEDAQRFRKQAEEI-GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585

Query: 1034 AQQRLQLDRARQDL 1047
             +   +L+R ++ L
Sbjct: 2586 REAIAELEREKEKL 2599



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 140/533 (26%), Positives = 239/533 (44%), Gaps = 74/533 (13%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            QK L  A+ + Q   AE +A         A  + ++ + ELE+ Q +L  G+ QQ+  A+
Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAE 1849

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLA 680
             ELI    R+  +  E   Q  EE L R   E +A    + QE E   A++ A+ +  LA
Sbjct: 1850 QELIRL--RAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLA 1906

Query: 681  AIAQEKDQEMERLRELQRASILDMRRDHE--EQLQRLKLLKDR--------EVDAATSAT 730
            + A+ +++      + ++    +  R  E  E+  RL+ L +         E DAA    
Sbjct: 1907 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1966

Query: 731  SHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRD---EQLRALQERLG 787
               R L               +L++  EA+ L T  E E+ +++++   E+LR L E   
Sbjct: 1967 EAERVL-------------AEKLAAIGEATRLKT--EAEIALKEKEAENERLRRLAEDEA 2011

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ---RK 844
             Q+R +EE+ ++ +  I +  A+L + S   E ER +   E +  +  +R +EE+    K
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDS-ELERQKGLVEDTLRQ--RRQVEEEILALK 2068

Query: 845  VTAQQMAMERAELE--------------RAKS-ALLEEQKSVMLKCGEERRR-------- 881
             + ++ A  +AELE              R+K  A LE  +   L   EERRR        
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2128

Query: 882  --LAAEWAEFSAQQKLSKERAER------EAERALQVDTQREGTLISLAKEQAELKIRAS 933
              LAAE  E + Q+K + E  ER      EA R  +   Q     + LA+E A+ +++A 
Sbjct: 2129 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187

Query: 934  ELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGER 993
            E +A    +  +   L+Q  Q+ +   +++   A   +  AEE E     A  +  +  R
Sbjct: 2188 E-KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2246

Query: 994  ALREAQQVQ--AEQQARLQA-VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRA 1043
             + EA++++  AE+QA+ +A  Q   E+LRK+ +          Q  L+  +A
Sbjct: 2247 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 149/642 (23%), Positives = 264/642 (41%), Gaps = 160/642 (24%)

Query: 559  EYQKQLLAAQVQLQCSPAE--LQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ 616
            E  +Q  A Q+QL    A+  LQAE    +A    ++ + ++L+    Q + +L  L+ +
Sbjct: 2163 ERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2219

Query: 617  HQADLELIESAHRSRIKVLETSYQQRE-----ERLRRENEELS-ARYLSQC------QEA 664
             +A     E A  +R++    + Q R      ERL++  EE + AR  +Q       +EA
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2279

Query: 665  EQ-----ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASI--------LDMRR-DHEE 710
            EQ     A+AE  A  Q++ A    EK ++       Q+A +        L +   DH++
Sbjct: 2280 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2339

Query: 711  QL--QRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             L  + L+ LK    +AA   +     L S+  QME+ S    +L +R+EA      + R
Sbjct: 2340 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS----KLKARIEA------ENR 2389

Query: 769  ELGIRQRDEQLRALQERLGQQQ-------------------RDMEEERSRQQEVIG---- 805
             L +R +D   R LQE   + +                   R + EE   QQ  +     
Sbjct: 2390 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2449

Query: 806  --KMEA-----RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELE 858
              KM+A     RL  ++ LL+Q++         A+   R L+E ++  AQQ+A E    +
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQK-------ELAQEQARRLQEDKEQMAQQLAEETQGFQ 2502

Query: 859  RAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVD------- 911
            R     LE ++   L+   E  RL    AE S  Q  ++E A+R  ++A ++        
Sbjct: 2503 RT----LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2558

Query: 912  --TQREGTLISLA------------------------KEQAELKIRASELRAEEKQ---- 941
              TQ + TL+                           KE+ + + +  +L++EE Q    
Sbjct: 2559 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2618

Query: 942  ---------------------------LAAERAALEQ-------ERQELRLEKERINATA 967
                                       +  E+A LEQ       + Q+LR E++R     
Sbjct: 2619 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678

Query: 968  LRVKLRAEEVESMSKVASEKYEEGE---RALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024
             + + R   V SM +    ++E  E   R   E QQ++ +++ + + + ++ +RLR+Q Q
Sbjct: 2679 EQERQRL--VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736

Query: 1025 HMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQ 1066
             + ++H +      ++  ++     +L        GPAA ++
Sbjct: 2737 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2778



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 125/546 (22%), Positives = 243/546 (44%), Gaps = 76/546 (13%)

Query: 560  YQKQLLAAQV------QLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSL 613
            +++QL  AQ       +L+ + A L+   L +QA   +      + EL  AQ    +G  
Sbjct: 1245 HEEQLKEAQAVPATLPELEATKASLKK--LRAQAEAQQPTFDALRDELRGAQE---VGER 1299

Query: 614  QQQHQADLELIESAHRSRIKVL---------ETSYQQRE-ERLRRE-------NEELSA- 655
             QQ   + ++     R R+  L         +T  +QRE E+L R+        + L A 
Sbjct: 1300 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1359

Query: 656  -----RYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRAS--ILDMRRDH 708
                 R   Q Q    A ++   +  R+  A+ +E ++  E++ E QR +   ++  +D+
Sbjct: 1360 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1419

Query: 709  EEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
            E QL   K   +     A      + S  S+I +     +   EL++        TSQ  
Sbjct: 1420 ELQLVTYKAQLEPVASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTT-------LTSQY- 1470

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAE 828
               I+   E LR ++E    ++R  E++R+ ++E + ++EA L +Q +L E         
Sbjct: 1471 ---IKFISETLRRMEE----EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1523

Query: 829  QSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEE--QKSVMLKCGEERRRLAAEW 886
            + +A+ +Q+ ++E+  V  ++ A++  + +R+    L++  Q S      + R+  AAE 
Sbjct: 1524 EREAKELQQRMQEE-VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1582

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAE-------- 938
            +    ++++   R + EA    +   + E   +    E+AE + R ++  AE        
Sbjct: 1583 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1642

Query: 939  ----EKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVAS-EKYEEGER 993
                ++Q   E A+  +   E   EK+R       ++L+AEE E   + A  E+  + + 
Sbjct: 1643 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1702

Query: 994  ALREAQQ-VQAEQQARLQAVQQQQERLRK--QEQHMH-----QEHLSLAQQRLQLDRARQ 1045
            AL  AQ+  +AE Q++  +  ++  +L +  QE+H+      +E    AQQ+ + +RAR+
Sbjct: 1703 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1762

Query: 1046 DLPSSL 1051
            +    L
Sbjct: 1763 EAEREL 1768



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 93/427 (21%), Positives = 162/427 (37%), Gaps = 71/427 (16%)

Query: 662  QEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDR 721
            QEA++A   L AQHQ  L  +  +   +M+ L   Q      +RRD       ++L+  R
Sbjct: 1000 QEAQEAVTRLEAQHQA-LVTLWHQLHVDMKSLLAWQ-----SLRRD-------VQLI--R 1044

Query: 722  EVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRA 781
                AT  T         +H +E    +   L    +A      ++R +  R+       
Sbjct: 1045 SWSLATFRTLKPEEQRQALHSLELHYQAF--LRDSQDAGGFGP-EDRLMAEREYGSCSHH 1101

Query: 782  LQERLGQQQRDMEEERSRQQEVIGKMEARLN-EQSRLLEQERWRVTAEQSKAESMQRALE 840
             Q+ L   ++  +EE   Q+ +    + RL  E        R R+  ++  A    + + 
Sbjct: 1102 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1161

Query: 841  EQRKVTAQQMAMER------AELERA--------KSALLEEQKSVMLKCGEERRRLAAEW 886
            EQ+K  A+   + +      AE E+          +  L  +  + L   E+ R L+A +
Sbjct: 1162 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1221

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQR--------------EGTLISLAKEQAELKIR- 931
             E      L   R  + AE  L+   ++              E T  SL K +A+ + + 
Sbjct: 1222 LEKLKTISLVI-RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1280

Query: 932  ------------ASELRAEEKQLAAER-AALEQERQELRLEKERINATALRVKLRAEEVE 978
                        A E+    +Q   ER   +E+ R+ +    ER  A   +  +R  E+E
Sbjct: 1281 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1340

Query: 979  SMSKVASEKYEEG-------ERALREAQQVQAEQQARLQAVQQQ--QERLRKQEQHMHQE 1029
             + +      E         + A R  +Q+QA   A  QAV++Q  QE+   +E   H E
Sbjct: 1341 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1400

Query: 1030 HLSLAQQ 1036
             +   Q+
Sbjct: 1401 KVEECQR 1407


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  110 bits (276), Expect = 6e-24
 Identities = 142/589 (24%), Positives = 258/589 (43%), Gaps = 88/589 (14%)

Query: 559  EYQKQLLAAQVQLQCSPA----ELQAELLHSQARLAE--LEAQVRKLELERAQHELLLGS 612
            E Q+QL  A  Q +        ELQ  +     R  E  ++AQ +K  ++    +L   S
Sbjct: 1348 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1407

Query: 613  LQQQHQADLELIESAHRSRIKV----------LETSYQQRE------ERLRRENEELSAR 656
             + + QA     E+A RSR+++          LE + +QR       + LR   EE  A+
Sbjct: 1408 -EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1466

Query: 657  YLSQCQEAEQARAELTAQHQRRLAA---IAQEKDQEMERLRELQRA--SILDMRRDHEEQ 711
                 +EAE+ R ++  + QR+  A   +A     E E  RE QRA  ++ ++R   EE 
Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1526

Query: 712  LQRLK---LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             +RL+   + + R+V  A   T+   +   +  +   F+    +L   ++  H+  +Q R
Sbjct: 1527 ERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1585

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIG-KMEARLNEQSRLLEQERWRVTA 827
            E   R+  +Q  A + R  + +R++E  + +  E +  +++A    Q + L Q       
Sbjct: 1586 EEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644

Query: 828  EQSKAESMQRALEEQRKVTAQQMAMERAELER------AKSALLEEQKSVMLKC----GE 877
            E+++ E+ +R   E++ V  +++A +  E +R      A+  L  EQ+ + L+     GE
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704

Query: 878  ERRRL----------------------AAEWAEFSAQQKL---SKERAEREAERALQVDT 912
            ++R+L                       AE A+  A+ ++   SK RAE E+    +   
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764

Query: 913  QR----EGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATAL 968
            QR     G    LA+E A L+  A E +  ++QLA E AA +      R E ER+ A  L
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAK-RQRQLAEEDAARQ------RAEAERVLAEKL 1817

Query: 969  RVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQA--------VQQQQERLR 1020
                 A  +++ +++A ++ E     LR   + +A Q+ RL+         ++++  +LR
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877

Query: 1021 KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSAL 1069
            K      +    L +  L+  R  ++   +L   F +A    A  +  L
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1926



 Score =  108 bits (270), Expect = 3e-23
 Identities = 127/512 (24%), Positives = 231/512 (45%), Gaps = 62/512 (12%)

Query: 568  QVQLQCSP-AELQA---ELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ------H 617
            Q Q+Q  P A+ QA   +L   QA L E+E    K+E  +   +  + +++        +
Sbjct: 1208 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1267

Query: 618  QADLELIES-AHRSRIKVLETSYQQREERLRRENEELS----------ARYLSQCQEAEQ 666
            +A LE + S A + +++    S  Q    LR    EL+          +  L + +E E+
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327

Query: 667  ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAA 726
               +  A+ + RLA +    +++ + L E    +     R+ +E  QR++    R  +AA
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386

Query: 727  TSATSHTRSLNSIIHQMEKFSSSLHELSSR----VEASHLTTSQERELGIRQRDEQLRAL 782
              A    RS+   + Q+ + S +  +  +R     E S L   +E    IR    QL A 
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE----IRVVRLQLEAT 1442

Query: 783  QERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ 842
            + + G  + +++  R+R +      EA   ++    E ER R   +       Q  +E  
Sbjct: 1443 ERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1496

Query: 843  RKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAER 902
             +V A+      AE  R K   L+  + + L+  E  RRL     E + Q +++ E A+R
Sbjct: 1497 SRVKAE------AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1550

Query: 903  EAERALQVDTQREGTLISLAKEQAELK-------IRASELRAEEKQLAAERAALEQERQE 955
             AE  LQ          S A++ A+L+       +  ++LR E ++ A ++A  E+ R+E
Sbjct: 1551 SAEAELQ------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1604

Query: 956  LRLEKERINA---TALRVKLRAEEV---ESMSKVASEKY-EEGERALREAQQVQAEQQAR 1008
               E ER       ALR++L+AEEV   +S+++  +EK  EE ER  R   + + +   +
Sbjct: 1605 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1664

Query: 1009 LQAVQQQQERLRKQEQHMHQEHLSLAQQRLQL 1040
             +  +Q+ E+ R+  +   Q+ L+  Q+ ++L
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1696



 Score =  106 bits (264), Expect = 1e-22
 Identities = 135/556 (24%), Positives = 256/556 (46%), Gaps = 56/556 (10%)

Query: 551  ARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLL 610
            AR    + E +++   A+ ++Q S A  +      +A L E+E    K+E  R   E   
Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2004

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSY----QQREERLRRENEELSARYLSQCQEAEQ 666
               +Q+    L+L + A + R++  E ++    QQ+E+ L++  ++  +       EAE 
Sbjct: 2005 -RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2063

Query: 667  ARAELTAQHQRRLAA--IAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVD 724
            AR       + R+ A   A +  +++E    L++++    +   + Q    KL K+ E +
Sbjct: 2064 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2123

Query: 725  AATSATSHTRSL------NSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR--- 775
            AA  A +   +L      ++ + + +KF+       ++VE    T   + E    Q+   
Sbjct: 2124 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183

Query: 776  DEQLRALQ---ERLGQQQRDMEEERSR---QQEVIGKMEARLNEQSR--LLEQERWRVTA 827
            DE+L+ L+       +Q+  +EEE      Q E + K++AR+  ++R  +L  +      
Sbjct: 2184 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2243

Query: 828  EQSKAESMQRALEEQRK--VTAQQMAMER--AELERAKS-ALLEEQKSVMLKCGEERRRL 882
             Q +AE M++  EE  +  V AQ+ A  R  AE + A+  AL E+     ++  +E  RL
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303

Query: 883  AAEWAEFSAQQKLSKERAER----EAERALQVDTQREG---TLISLAKEQAELKIRASEL 935
             AE      Q++L++E+A R    + + A Q+  + +G   TL +  + Q E+   A  L
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363

Query: 936  RAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEE----VESMSKVASEKYEEG 991
            +    +++  +A  E++ Q  R + E I     R +L  +E    V+++     +   + 
Sbjct: 2364 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2423

Query: 992  ERALREA------QQVQAEQQARLQAVQQ------QQERLRKQEQHMHQEHLSLAQQRLQ 1039
            ER LREA      ++ + +Q+A+L  ++       QQE+L ++ Q + Q  LS     LQ
Sbjct: 2424 ER-LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482

Query: 1040 LDRARQDLPSSLVGLF 1055
             +R  +   + L  LF
Sbjct: 2483 RERFIEQEKAKLEQLF 2498



 Score =  105 bits (261), Expect = 3e-22
 Identities = 127/515 (24%), Positives = 219/515 (42%), Gaps = 69/515 (13%)

Query: 568  QVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESA 627
            QV L+ +    +AEL   +A  AE  AQ+ +             SLQ++H A  +L E A
Sbjct: 1542 QVALETAQRSAEAELQSKRASFAEKTAQLER-------------SLQEEHVAVAQLREEA 1588

Query: 628  HRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD 687
             R          Q   ER R E E    R+  +  EA + R +     Q++  A A+ + 
Sbjct: 1589 ER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1642

Query: 688  QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATS-----ATSHTRSLNSIIHQ 742
            Q+ E  RE +R    + +   + +L   +L K R++   T+     A      L +   Q
Sbjct: 1643 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1702

Query: 743  MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQE 802
             E+    L E  +R++      +Q+R+    +  +    ++  L  + R  EE RS  ++
Sbjct: 1703 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1762

Query: 803  VIGKMEARLNEQSRLLEQE-RWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERA- 860
               ++EA       L E+  R R  AE++K          QR++  +  A +RAE ER  
Sbjct: 1763 SKQRLEAEAGRFRELAEEAARLRALAEEAK---------RQRQLAEEDAARQRAEAERVL 1813

Query: 861  --------KSALLEEQKSVMLKC----GEERRRLAAEWA-------EFSAQQKLSKERAE 901
                    ++  L+ +  + LK      E  RRLA + A       E +AQ K   E   
Sbjct: 1814 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873

Query: 902  REAERALQVDTQREGTLIS-LAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLE- 959
             +  +A   + +R+  L+    +++ +++     L+A  ++ AA +A LE E   +R   
Sbjct: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1933

Query: 960  ------KERINATALRVKLRAEEVESMSKVASEKYEEGERALREA---QQVQAEQQARLQ 1010
                  KE+    A R +  A E E   + A E+ ++   A  EA   ++   E+  RL+
Sbjct: 1934 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1993

Query: 1011 AVQQQQERLRKQEQHMHQEHLSLAQQ----RLQLD 1041
            A  ++  RLR++ +      L LAQ+    RLQ +
Sbjct: 1994 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028



 Score =  103 bits (258), Expect = 7e-22
 Identities = 133/554 (24%), Positives = 245/554 (44%), Gaps = 78/554 (14%)

Query: 559  EYQKQLLAAQVQLQ---CSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLG---- 611
            + ++++LA +   +      AEL+ EL   ++   +      + ELE A+   L      
Sbjct: 1900 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1959

Query: 612  ---SLQQQHQADLELIESAHRSRIKVLE-----TSYQQREERLRRENEELSARYLSQCQE 663
                 +++ Q  L   E A R R   LE      +  +   RLR   E+ SAR L   QE
Sbjct: 1960 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2019

Query: 664  AEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQR-LKLLKDRE 722
            A Q R  L A+ +    A+ Q+K+QE+++  + Q  S+LD  R   E  +R  +  ++  
Sbjct: 2020 AAQKR--LQAEEKAHAFAV-QQKEQELQQTLQ-QEQSVLDQLRGEAEAARRAAEEAEEAR 2075

Query: 723  VDAATSATSHTRSLNSIIHQMEKFSSSLHE-----LSSRVEASHLTTSQERELGIRQRDE 777
            V A   A    R     + + E+   S  E       ++  A  L    E+E   R + E
Sbjct: 2076 VQAEREAAQSRRQ----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2131

Query: 778  QLRALQERLGQQQRDMEE--------ERSRQQEVIGKMEARLNE---QSRLLEQERWRVT 826
            Q    Q++    + +  +        ++++ ++ +  +  +L E   Q  LL++E  R+ 
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2191

Query: 827  AEQSKAESMQRALEEQR---KVTAQQMAMERAELERAKSAL-----------LEEQKSVM 872
            AE ++A   +  +EE+    +V  ++++  +A +E    AL           L+E+   M
Sbjct: 2192 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2251

Query: 873  LKCGEERRRL--AAEWA--------EFSAQQKLSKERAEREAERALQVDTQREGTLISLA 922
             +  EE  RL  AA+ A        E  AQQ+   E+  +E  +A+Q  T+ +     L 
Sbjct: 2252 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELL 2310

Query: 923  KEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKER-----INATALRVKLRAEEV 977
            ++Q EL    +    E+K+  A++ A E +  +  LE ER     ++A A R+KLR  E 
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE- 2369

Query: 978  ESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQ----ERLRKQEQHMHQEHLSL 1033
              MS+  +   E+ +R  ++A+++  E+  R +   Q++    + L  Q Q    +   L
Sbjct: 2370 --MSRAQARAEEDAQRFRKQAEEI-GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426

Query: 1034 AQQRLQLDRARQDL 1047
             +   +L+R ++ L
Sbjct: 2427 REAIAELEREKEKL 2440



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 140/533 (26%), Positives = 239/533 (44%), Gaps = 74/533 (13%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            QK L  A+ + Q   AE +A         A  + ++ + ELE+ Q +L  G+ QQ+  A+
Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAE 1690

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLA 680
             ELI    R+  +  E   Q  EE L R   E +A    + QE E   A++ A+ +  LA
Sbjct: 1691 QELIRL--RAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLA 1747

Query: 681  AIAQEKDQEMERLRELQRASILDMRRDHE--EQLQRLKLLKDR--------EVDAATSAT 730
            + A+ +++      + ++    +  R  E  E+  RL+ L +         E DAA    
Sbjct: 1748 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1807

Query: 731  SHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRD---EQLRALQERLG 787
               R L               +L++  EA+ L T  E E+ +++++   E+LR L E   
Sbjct: 1808 EAERVL-------------AEKLAAIGEATRLKT--EAEIALKEKEAENERLRRLAEDEA 1852

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ---RK 844
             Q+R +EE+ ++ +  I +  A+L + S   E ER +   E +  +  +R +EE+    K
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDS-ELERQKGLVEDTLRQ--RRQVEEEILALK 1909

Query: 845  VTAQQMAMERAELE--------------RAKS-ALLEEQKSVMLKCGEERRR-------- 881
             + ++ A  +AELE              R+K  A LE  +   L   EERRR        
Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1969

Query: 882  --LAAEWAEFSAQQKLSKERAER------EAERALQVDTQREGTLISLAKEQAELKIRAS 933
              LAAE  E + Q+K + E  ER      EA R  +   Q     + LA+E A+ +++A 
Sbjct: 1970 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028

Query: 934  ELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGER 993
            E +A    +  +   L+Q  Q+ +   +++   A   +  AEE E     A  +  +  R
Sbjct: 2029 E-KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2087

Query: 994  ALREAQQVQ--AEQQARLQA-VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRA 1043
             + EA++++  AE+QA+ +A  Q   E+LRK+ +          Q  L+  +A
Sbjct: 2088 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2140



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 149/642 (23%), Positives = 264/642 (41%), Gaps = 160/642 (24%)

Query: 559  EYQKQLLAAQVQLQCSPAE--LQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ 616
            E  +Q  A Q+QL    A+  LQAE    +A    ++ + ++L+    Q + +L  L+ +
Sbjct: 2004 ERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2060

Query: 617  HQADLELIESAHRSRIKVLETSYQQRE-----ERLRRENEELS-ARYLSQC------QEA 664
             +A     E A  +R++    + Q R      ERL++  EE + AR  +Q       +EA
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2120

Query: 665  EQ-----ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASI--------LDMRR-DHEE 710
            EQ     A+AE  A  Q++ A    EK ++       Q+A +        L +   DH++
Sbjct: 2121 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2180

Query: 711  QL--QRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             L  + L+ LK    +AA   +     L S+  QME+ S    +L +R+EA      + R
Sbjct: 2181 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS----KLKARIEA------ENR 2230

Query: 769  ELGIRQRDEQLRALQERLGQQQ-------------------RDMEEERSRQQEVIG---- 805
             L +R +D   R LQE   + +                   R + EE   QQ  +     
Sbjct: 2231 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2290

Query: 806  --KMEA-----RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELE 858
              KM+A     RL  ++ LL+Q++         A+   R L+E ++  AQQ+A E    +
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQK-------ELAQEQARRLQEDKEQMAQQLAEETQGFQ 2343

Query: 859  RAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVD------- 911
            R     LE ++   L+   E  RL    AE S  Q  ++E A+R  ++A ++        
Sbjct: 2344 RT----LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2399

Query: 912  --TQREGTLISLA------------------------KEQAELKIRASELRAEEKQ---- 941
              TQ + TL+                           KE+ + + +  +L++EE Q    
Sbjct: 2400 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2459

Query: 942  ---------------------------LAAERAALEQ-------ERQELRLEKERINATA 967
                                       +  E+A LEQ       + Q+LR E++R     
Sbjct: 2460 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2519

Query: 968  LRVKLRAEEVESMSKVASEKYEEGE---RALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024
             + + R   V SM +    ++E  E   R   E QQ++ +++ + + + ++ +RLR+Q Q
Sbjct: 2520 EQERQRL--VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577

Query: 1025 HMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQ 1066
             + ++H +      ++  ++     +L        GPAA ++
Sbjct: 2578 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2619



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 125/546 (22%), Positives = 243/546 (44%), Gaps = 76/546 (13%)

Query: 560  YQKQLLAAQV------QLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSL 613
            +++QL  AQ       +L+ + A L+   L +QA   +      + EL  AQ    +G  
Sbjct: 1086 HEEQLKEAQAVPATLPELEATKASLKK--LRAQAEAQQPTFDALRDELRGAQE---VGER 1140

Query: 614  QQQHQADLELIESAHRSRIKVL---------ETSYQQRE-ERLRRE-------NEELSA- 655
             QQ   + ++     R R+  L         +T  +QRE E+L R+        + L A 
Sbjct: 1141 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1200

Query: 656  -----RYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRAS--ILDMRRDH 708
                 R   Q Q    A ++   +  R+  A+ +E ++  E++ E QR +   ++  +D+
Sbjct: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260

Query: 709  EEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
            E QL   K   +     A      + S  S+I +     +   EL++        TSQ  
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTT-------LTSQY- 1311

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAE 828
               I+   E LR ++E    ++R  E++R+ ++E + ++EA L +Q +L E         
Sbjct: 1312 ---IKFISETLRRMEE----EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1364

Query: 829  QSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEE--QKSVMLKCGEERRRLAAEW 886
            + +A+ +Q+ ++E+  V  ++ A++  + +R+    L++  Q S      + R+  AAE 
Sbjct: 1365 EREAKELQQRMQEE-VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1423

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAE-------- 938
            +    ++++   R + EA    +   + E   +    E+AE + R ++  AE        
Sbjct: 1424 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1483

Query: 939  ----EKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVAS-EKYEEGER 993
                ++Q   E A+  +   E   EK+R       ++L+AEE E   + A  E+  + + 
Sbjct: 1484 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1543

Query: 994  ALREAQQ-VQAEQQARLQAVQQQQERLRK--QEQHMH-----QEHLSLAQQRLQLDRARQ 1045
            AL  AQ+  +AE Q++  +  ++  +L +  QE+H+      +E    AQQ+ + +RAR+
Sbjct: 1544 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1603

Query: 1046 DLPSSL 1051
            +    L
Sbjct: 1604 EAEREL 1609



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 93/427 (21%), Positives = 162/427 (37%), Gaps = 71/427 (16%)

Query: 662  QEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDR 721
            QEA++A   L AQHQ  L  +  +   +M+ L   Q      +RRD       ++L+  R
Sbjct: 841  QEAQEAVTRLEAQHQA-LVTLWHQLHVDMKSLLAWQ-----SLRRD-------VQLI--R 885

Query: 722  EVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRA 781
                AT  T         +H +E    +   L    +A      ++R +  R+       
Sbjct: 886  SWSLATFRTLKPEEQRQALHSLELHYQAF--LRDSQDAGGFGP-EDRLMAEREYGSCSHH 942

Query: 782  LQERLGQQQRDMEEERSRQQEVIGKMEARLN-EQSRLLEQERWRVTAEQSKAESMQRALE 840
             Q+ L   ++  +EE   Q+ +    + RL  E        R R+  ++  A    + + 
Sbjct: 943  YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1002

Query: 841  EQRKVTAQQMAMER------AELERA--------KSALLEEQKSVMLKCGEERRRLAAEW 886
            EQ+K  A+   + +      AE E+          +  L  +  + L   E+ R L+A +
Sbjct: 1003 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1062

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQR--------------EGTLISLAKEQAELKIR- 931
             E      L   R  + AE  L+   ++              E T  SL K +A+ + + 
Sbjct: 1063 LEKLKTISLVI-RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1121

Query: 932  ------------ASELRAEEKQLAAER-AALEQERQELRLEKERINATALRVKLRAEEVE 978
                        A E+    +Q   ER   +E+ R+ +    ER  A   +  +R  E+E
Sbjct: 1122 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1181

Query: 979  SMSKVASEKYEEG-------ERALREAQQVQAEQQARLQAVQQQ--QERLRKQEQHMHQE 1029
             + +      E         + A R  +Q+QA   A  QAV++Q  QE+   +E   H E
Sbjct: 1182 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1241

Query: 1030 HLSLAQQ 1036
             +   Q+
Sbjct: 1242 KVEECQR 1248


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  110 bits (276), Expect = 6e-24
 Identities = 142/589 (24%), Positives = 258/589 (43%), Gaps = 88/589 (14%)

Query: 559  EYQKQLLAAQVQLQCSPA----ELQAELLHSQARLAE--LEAQVRKLELERAQHELLLGS 612
            E Q+QL  A  Q +        ELQ  +     R  E  ++AQ +K  ++    +L   S
Sbjct: 1356 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1415

Query: 613  LQQQHQADLELIESAHRSRIKV----------LETSYQQRE------ERLRRENEELSAR 656
             + + QA     E+A RSR+++          LE + +QR       + LR   EE  A+
Sbjct: 1416 -EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1474

Query: 657  YLSQCQEAEQARAELTAQHQRRLAA---IAQEKDQEMERLRELQRA--SILDMRRDHEEQ 711
                 +EAE+ R ++  + QR+  A   +A     E E  RE QRA  ++ ++R   EE 
Sbjct: 1475 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1534

Query: 712  LQRLK---LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             +RL+   + + R+V  A   T+   +   +  +   F+    +L   ++  H+  +Q R
Sbjct: 1535 ERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1593

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIG-KMEARLNEQSRLLEQERWRVTA 827
            E   R+  +Q  A + R  + +R++E  + +  E +  +++A    Q + L Q       
Sbjct: 1594 EEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1652

Query: 828  EQSKAESMQRALEEQRKVTAQQMAMERAELER------AKSALLEEQKSVMLKC----GE 877
            E+++ E+ +R   E++ V  +++A +  E +R      A+  L  EQ+ + L+     GE
Sbjct: 1653 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712

Query: 878  ERRRL----------------------AAEWAEFSAQQKL---SKERAEREAERALQVDT 912
            ++R+L                       AE A+  A+ ++   SK RAE E+    +   
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1772

Query: 913  QR----EGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATAL 968
            QR     G    LA+E A L+  A E +  ++QLA E AA +      R E ER+ A  L
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAK-RQRQLAEEDAARQ------RAEAERVLAEKL 1825

Query: 969  RVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQA--------VQQQQERLR 1020
                 A  +++ +++A ++ E     LR   + +A Q+ RL+         ++++  +LR
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885

Query: 1021 KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSAL 1069
            K      +    L +  L+  R  ++   +L   F +A    A  +  L
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1934



 Score =  108 bits (270), Expect = 3e-23
 Identities = 127/512 (24%), Positives = 231/512 (45%), Gaps = 62/512 (12%)

Query: 568  QVQLQCSP-AELQA---ELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ------H 617
            Q Q+Q  P A+ QA   +L   QA L E+E    K+E  +   +  + +++        +
Sbjct: 1216 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1275

Query: 618  QADLELIES-AHRSRIKVLETSYQQREERLRRENEELS----------ARYLSQCQEAEQ 666
            +A LE + S A + +++    S  Q    LR    EL+          +  L + +E E+
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335

Query: 667  ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAA 726
               +  A+ + RLA +    +++ + L E    +     R+ +E  QR++    R  +AA
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1394

Query: 727  TSATSHTRSLNSIIHQMEKFSSSLHELSSR----VEASHLTTSQERELGIRQRDEQLRAL 782
              A    RS+   + Q+ + S +  +  +R     E S L   +E    IR    QL A 
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE----IRVVRLQLEAT 1450

Query: 783  QERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ 842
            + + G  + +++  R+R +      EA   ++    E ER R   +       Q  +E  
Sbjct: 1451 ERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1504

Query: 843  RKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAER 902
             +V A+      AE  R K   L+  + + L+  E  RRL     E + Q +++ E A+R
Sbjct: 1505 SRVKAE------AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1558

Query: 903  EAERALQVDTQREGTLISLAKEQAELK-------IRASELRAEEKQLAAERAALEQERQE 955
             AE  LQ          S A++ A+L+       +  ++LR E ++ A ++A  E+ R+E
Sbjct: 1559 SAEAELQ------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1612

Query: 956  LRLEKERINA---TALRVKLRAEEV---ESMSKVASEKY-EEGERALREAQQVQAEQQAR 1008
               E ER       ALR++L+AEEV   +S+++  +EK  EE ER  R   + + +   +
Sbjct: 1613 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1672

Query: 1009 LQAVQQQQERLRKQEQHMHQEHLSLAQQRLQL 1040
             +  +Q+ E+ R+  +   Q+ L+  Q+ ++L
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1704



 Score =  106 bits (264), Expect = 1e-22
 Identities = 135/556 (24%), Positives = 256/556 (46%), Gaps = 56/556 (10%)

Query: 551  ARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLL 610
            AR    + E +++   A+ ++Q S A  +      +A L E+E    K+E  R   E   
Sbjct: 1956 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2012

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSY----QQREERLRRENEELSARYLSQCQEAEQ 666
               +Q+    L+L + A + R++  E ++    QQ+E+ L++  ++  +       EAE 
Sbjct: 2013 -RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2071

Query: 667  ARAELTAQHQRRLAA--IAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVD 724
            AR       + R+ A   A +  +++E    L++++    +   + Q    KL K+ E +
Sbjct: 2072 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2131

Query: 725  AATSATSHTRSL------NSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR--- 775
            AA  A +   +L      ++ + + +KF+       ++VE    T   + E    Q+   
Sbjct: 2132 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2191

Query: 776  DEQLRALQ---ERLGQQQRDMEEERSR---QQEVIGKMEARLNEQSR--LLEQERWRVTA 827
            DE+L+ L+       +Q+  +EEE      Q E + K++AR+  ++R  +L  +      
Sbjct: 2192 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2251

Query: 828  EQSKAESMQRALEEQRK--VTAQQMAMER--AELERAKS-ALLEEQKSVMLKCGEERRRL 882
             Q +AE M++  EE  +  V AQ+ A  R  AE + A+  AL E+     ++  +E  RL
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311

Query: 883  AAEWAEFSAQQKLSKERAER----EAERALQVDTQREG---TLISLAKEQAELKIRASEL 935
             AE      Q++L++E+A R    + + A Q+  + +G   TL +  + Q E+   A  L
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371

Query: 936  RAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEE----VESMSKVASEKYEEG 991
            +    +++  +A  E++ Q  R + E I     R +L  +E    V+++     +   + 
Sbjct: 2372 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2431

Query: 992  ERALREA------QQVQAEQQARLQAVQQ------QQERLRKQEQHMHQEHLSLAQQRLQ 1039
            ER LREA      ++ + +Q+A+L  ++       QQE+L ++ Q + Q  LS     LQ
Sbjct: 2432 ER-LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490

Query: 1040 LDRARQDLPSSLVGLF 1055
             +R  +   + L  LF
Sbjct: 2491 RERFIEQEKAKLEQLF 2506



 Score =  105 bits (261), Expect = 3e-22
 Identities = 127/515 (24%), Positives = 219/515 (42%), Gaps = 69/515 (13%)

Query: 568  QVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESA 627
            QV L+ +    +AEL   +A  AE  AQ+ +             SLQ++H A  +L E A
Sbjct: 1550 QVALETAQRSAEAELQSKRASFAEKTAQLER-------------SLQEEHVAVAQLREEA 1596

Query: 628  HRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD 687
             R          Q   ER R E E    R+  +  EA + R +     Q++  A A+ + 
Sbjct: 1597 ER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1650

Query: 688  QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATS-----ATSHTRSLNSIIHQ 742
            Q+ E  RE +R    + +   + +L   +L K R++   T+     A      L +   Q
Sbjct: 1651 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1710

Query: 743  MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQE 802
             E+    L E  +R++      +Q+R+    +  +    ++  L  + R  EE RS  ++
Sbjct: 1711 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1770

Query: 803  VIGKMEARLNEQSRLLEQE-RWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERA- 860
               ++EA       L E+  R R  AE++K          QR++  +  A +RAE ER  
Sbjct: 1771 SKQRLEAEAGRFRELAEEAARLRALAEEAK---------RQRQLAEEDAARQRAEAERVL 1821

Query: 861  --------KSALLEEQKSVMLKC----GEERRRLAAEWA-------EFSAQQKLSKERAE 901
                    ++  L+ +  + LK      E  RRLA + A       E +AQ K   E   
Sbjct: 1822 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1881

Query: 902  REAERALQVDTQREGTLIS-LAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLE- 959
             +  +A   + +R+  L+    +++ +++     L+A  ++ AA +A LE E   +R   
Sbjct: 1882 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1941

Query: 960  ------KERINATALRVKLRAEEVESMSKVASEKYEEGERALREA---QQVQAEQQARLQ 1010
                  KE+    A R +  A E E   + A E+ ++   A  EA   ++   E+  RL+
Sbjct: 1942 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2001

Query: 1011 AVQQQQERLRKQEQHMHQEHLSLAQQ----RLQLD 1041
            A  ++  RLR++ +      L LAQ+    RLQ +
Sbjct: 2002 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036



 Score =  103 bits (258), Expect = 7e-22
 Identities = 133/554 (24%), Positives = 245/554 (44%), Gaps = 78/554 (14%)

Query: 559  EYQKQLLAAQVQLQ---CSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLG---- 611
            + ++++LA +   +      AEL+ EL   ++   +      + ELE A+   L      
Sbjct: 1908 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1967

Query: 612  ---SLQQQHQADLELIESAHRSRIKVLE-----TSYQQREERLRRENEELSARYLSQCQE 663
                 +++ Q  L   E A R R   LE      +  +   RLR   E+ SAR L   QE
Sbjct: 1968 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2027

Query: 664  AEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQR-LKLLKDRE 722
            A Q R  L A+ +    A+ Q+K+QE+++  + Q  S+LD  R   E  +R  +  ++  
Sbjct: 2028 AAQKR--LQAEEKAHAFAV-QQKEQELQQTLQ-QEQSVLDQLRGEAEAARRAAEEAEEAR 2083

Query: 723  VDAATSATSHTRSLNSIIHQMEKFSSSLHE-----LSSRVEASHLTTSQERELGIRQRDE 777
            V A   A    R     + + E+   S  E       ++  A  L    E+E   R + E
Sbjct: 2084 VQAEREAAQSRRQ----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2139

Query: 778  QLRALQERLGQQQRDMEE--------ERSRQQEVIGKMEARLNE---QSRLLEQERWRVT 826
            Q    Q++    + +  +        ++++ ++ +  +  +L E   Q  LL++E  R+ 
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2199

Query: 827  AEQSKAESMQRALEEQR---KVTAQQMAMERAELERAKSAL-----------LEEQKSVM 872
            AE ++A   +  +EE+    +V  ++++  +A +E    AL           L+E+   M
Sbjct: 2200 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2259

Query: 873  LKCGEERRRL--AAEWA--------EFSAQQKLSKERAEREAERALQVDTQREGTLISLA 922
             +  EE  RL  AA+ A        E  AQQ+   E+  +E  +A+Q  T+ +     L 
Sbjct: 2260 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELL 2318

Query: 923  KEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKER-----INATALRVKLRAEEV 977
            ++Q EL    +    E+K+  A++ A E +  +  LE ER     ++A A R+KLR  E 
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE- 2377

Query: 978  ESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQ----ERLRKQEQHMHQEHLSL 1033
              MS+  +   E+ +R  ++A+++  E+  R +   Q++    + L  Q Q    +   L
Sbjct: 2378 --MSRAQARAEEDAQRFRKQAEEI-GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2434

Query: 1034 AQQRLQLDRARQDL 1047
             +   +L+R ++ L
Sbjct: 2435 REAIAELEREKEKL 2448



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 140/533 (26%), Positives = 239/533 (44%), Gaps = 74/533 (13%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            QK L  A+ + Q   AE +A         A  + ++ + ELE+ Q +L  G+ QQ+  A+
Sbjct: 1640 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAE 1698

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLA 680
             ELI    R+  +  E   Q  EE L R   E +A    + QE E   A++ A+ +  LA
Sbjct: 1699 QELIRL--RAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLA 1755

Query: 681  AIAQEKDQEMERLRELQRASILDMRRDHE--EQLQRLKLLKDR--------EVDAATSAT 730
            + A+ +++      + ++    +  R  E  E+  RL+ L +         E DAA    
Sbjct: 1756 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1815

Query: 731  SHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRD---EQLRALQERLG 787
               R L               +L++  EA+ L T  E E+ +++++   E+LR L E   
Sbjct: 1816 EAERVL-------------AEKLAAIGEATRLKT--EAEIALKEKEAENERLRRLAEDEA 1860

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ---RK 844
             Q+R +EE+ ++ +  I +  A+L + S   E ER +   E +  +  +R +EE+    K
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDS-ELERQKGLVEDTLRQ--RRQVEEEILALK 1917

Query: 845  VTAQQMAMERAELE--------------RAKS-ALLEEQKSVMLKCGEERRR-------- 881
             + ++ A  +AELE              R+K  A LE  +   L   EERRR        
Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1977

Query: 882  --LAAEWAEFSAQQKLSKERAER------EAERALQVDTQREGTLISLAKEQAELKIRAS 933
              LAAE  E + Q+K + E  ER      EA R  +   Q     + LA+E A+ +++A 
Sbjct: 1978 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036

Query: 934  ELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGER 993
            E +A    +  +   L+Q  Q+ +   +++   A   +  AEE E     A  +  +  R
Sbjct: 2037 E-KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2095

Query: 994  ALREAQQVQ--AEQQARLQA-VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRA 1043
             + EA++++  AE+QA+ +A  Q   E+LRK+ +          Q  L+  +A
Sbjct: 2096 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2148



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 149/642 (23%), Positives = 264/642 (41%), Gaps = 160/642 (24%)

Query: 559  EYQKQLLAAQVQLQCSPAE--LQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ 616
            E  +Q  A Q+QL    A+  LQAE    +A    ++ + ++L+    Q + +L  L+ +
Sbjct: 2012 ERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2068

Query: 617  HQADLELIESAHRSRIKVLETSYQQRE-----ERLRRENEELS-ARYLSQC------QEA 664
             +A     E A  +R++    + Q R      ERL++  EE + AR  +Q       +EA
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2128

Query: 665  EQ-----ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASI--------LDMRR-DHEE 710
            EQ     A+AE  A  Q++ A    EK ++       Q+A +        L +   DH++
Sbjct: 2129 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2188

Query: 711  QL--QRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             L  + L+ LK    +AA   +     L S+  QME+ S    +L +R+EA      + R
Sbjct: 2189 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS----KLKARIEA------ENR 2238

Query: 769  ELGIRQRDEQLRALQERLGQQQ-------------------RDMEEERSRQQEVIG---- 805
             L +R +D   R LQE   + +                   R + EE   QQ  +     
Sbjct: 2239 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2298

Query: 806  --KMEA-----RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELE 858
              KM+A     RL  ++ LL+Q++         A+   R L+E ++  AQQ+A E    +
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQK-------ELAQEQARRLQEDKEQMAQQLAEETQGFQ 2351

Query: 859  RAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVD------- 911
            R     LE ++   L+   E  RL    AE S  Q  ++E A+R  ++A ++        
Sbjct: 2352 RT----LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2407

Query: 912  --TQREGTLISLA------------------------KEQAELKIRASELRAEEKQ---- 941
              TQ + TL+                           KE+ + + +  +L++EE Q    
Sbjct: 2408 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2467

Query: 942  ---------------------------LAAERAALEQ-------ERQELRLEKERINATA 967
                                       +  E+A LEQ       + Q+LR E++R     
Sbjct: 2468 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2527

Query: 968  LRVKLRAEEVESMSKVASEKYEEGE---RALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024
             + + R   V SM +    ++E  E   R   E QQ++ +++ + + + ++ +RLR+Q Q
Sbjct: 2528 EQERQRL--VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585

Query: 1025 HMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQ 1066
             + ++H +      ++  ++     +L        GPAA ++
Sbjct: 2586 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2627



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 125/546 (22%), Positives = 243/546 (44%), Gaps = 76/546 (13%)

Query: 560  YQKQLLAAQV------QLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSL 613
            +++QL  AQ       +L+ + A L+   L +QA   +      + EL  AQ    +G  
Sbjct: 1094 HEEQLKEAQAVPATLPELEATKASLKK--LRAQAEAQQPTFDALRDELRGAQE---VGER 1148

Query: 614  QQQHQADLELIESAHRSRIKVL---------ETSYQQRE-ERLRRE-------NEELSA- 655
             QQ   + ++     R R+  L         +T  +QRE E+L R+        + L A 
Sbjct: 1149 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1208

Query: 656  -----RYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRAS--ILDMRRDH 708
                 R   Q Q    A ++   +  R+  A+ +E ++  E++ E QR +   ++  +D+
Sbjct: 1209 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1268

Query: 709  EEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
            E QL   K   +     A      + S  S+I +     +   EL++        TSQ  
Sbjct: 1269 ELQLVTYKAQLEPVASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTT-------LTSQY- 1319

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAE 828
               I+   E LR ++E    ++R  E++R+ ++E + ++EA L +Q +L E         
Sbjct: 1320 ---IKFISETLRRMEE----EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1372

Query: 829  QSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEE--QKSVMLKCGEERRRLAAEW 886
            + +A+ +Q+ ++E+  V  ++ A++  + +R+    L++  Q S      + R+  AAE 
Sbjct: 1373 EREAKELQQRMQEE-VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1431

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAE-------- 938
            +    ++++   R + EA    +   + E   +    E+AE + R ++  AE        
Sbjct: 1432 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1491

Query: 939  ----EKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVAS-EKYEEGER 993
                ++Q   E A+  +   E   EK+R       ++L+AEE E   + A  E+  + + 
Sbjct: 1492 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1551

Query: 994  ALREAQQ-VQAEQQARLQAVQQQQERLRK--QEQHMH-----QEHLSLAQQRLQLDRARQ 1045
            AL  AQ+  +AE Q++  +  ++  +L +  QE+H+      +E    AQQ+ + +RAR+
Sbjct: 1552 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1611

Query: 1046 DLPSSL 1051
            +    L
Sbjct: 1612 EAEREL 1617



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 93/427 (21%), Positives = 162/427 (37%), Gaps = 71/427 (16%)

Query: 662  QEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDR 721
            QEA++A   L AQHQ  L  +  +   +M+ L   Q      +RRD       ++L+  R
Sbjct: 849  QEAQEAVTRLEAQHQA-LVTLWHQLHVDMKSLLAWQ-----SLRRD-------VQLI--R 893

Query: 722  EVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRA 781
                AT  T         +H +E    +   L    +A      ++R +  R+       
Sbjct: 894  SWSLATFRTLKPEEQRQALHSLELHYQAF--LRDSQDAGGFGP-EDRLMAEREYGSCSHH 950

Query: 782  LQERLGQQQRDMEEERSRQQEVIGKMEARLN-EQSRLLEQERWRVTAEQSKAESMQRALE 840
             Q+ L   ++  +EE   Q+ +    + RL  E        R R+  ++  A    + + 
Sbjct: 951  YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1010

Query: 841  EQRKVTAQQMAMER------AELERA--------KSALLEEQKSVMLKCGEERRRLAAEW 886
            EQ+K  A+   + +      AE E+          +  L  +  + L   E+ R L+A +
Sbjct: 1011 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1070

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQR--------------EGTLISLAKEQAELKIR- 931
             E      L   R  + AE  L+   ++              E T  SL K +A+ + + 
Sbjct: 1071 LEKLKTISLVI-RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1129

Query: 932  ------------ASELRAEEKQLAAER-AALEQERQELRLEKERINATALRVKLRAEEVE 978
                        A E+    +Q   ER   +E+ R+ +    ER  A   +  +R  E+E
Sbjct: 1130 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1189

Query: 979  SMSKVASEKYEEG-------ERALREAQQVQAEQQARLQAVQQQ--QERLRKQEQHMHQE 1029
             + +      E         + A R  +Q+QA   A  QAV++Q  QE+   +E   H E
Sbjct: 1190 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1249

Query: 1030 HLSLAQQ 1036
             +   Q+
Sbjct: 1250 KVEECQR 1256


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  110 bits (276), Expect = 6e-24
 Identities = 142/589 (24%), Positives = 258/589 (43%), Gaps = 88/589 (14%)

Query: 559  EYQKQLLAAQVQLQCSPA----ELQAELLHSQARLAE--LEAQVRKLELERAQHELLLGS 612
            E Q+QL  A  Q +        ELQ  +     R  E  ++AQ +K  ++    +L   S
Sbjct: 1397 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1456

Query: 613  LQQQHQADLELIESAHRSRIKV----------LETSYQQRE------ERLRRENEELSAR 656
             + + QA     E+A RSR+++          LE + +QR       + LR   EE  A+
Sbjct: 1457 -EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1515

Query: 657  YLSQCQEAEQARAELTAQHQRRLAA---IAQEKDQEMERLRELQRA--SILDMRRDHEEQ 711
                 +EAE+ R ++  + QR+  A   +A     E E  RE QRA  ++ ++R   EE 
Sbjct: 1516 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1575

Query: 712  LQRLK---LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             +RL+   + + R+V  A   T+   +   +  +   F+    +L   ++  H+  +Q R
Sbjct: 1576 ERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1634

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIG-KMEARLNEQSRLLEQERWRVTA 827
            E   R+  +Q  A + R  + +R++E  + +  E +  +++A    Q + L Q       
Sbjct: 1635 EEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1693

Query: 828  EQSKAESMQRALEEQRKVTAQQMAMERAELER------AKSALLEEQKSVMLKC----GE 877
            E+++ E+ +R   E++ V  +++A +  E +R      A+  L  EQ+ + L+     GE
Sbjct: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753

Query: 878  ERRRL----------------------AAEWAEFSAQQKL---SKERAEREAERALQVDT 912
            ++R+L                       AE A+  A+ ++   SK RAE E+    +   
Sbjct: 1754 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813

Query: 913  QR----EGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATAL 968
            QR     G    LA+E A L+  A E +  ++QLA E AA +      R E ER+ A  L
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAK-RQRQLAEEDAARQ------RAEAERVLAEKL 1866

Query: 969  RVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQA--------VQQQQERLR 1020
                 A  +++ +++A ++ E     LR   + +A Q+ RL+         ++++  +LR
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926

Query: 1021 KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSAL 1069
            K      +    L +  L+  R  ++   +L   F +A    A  +  L
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1975



 Score =  108 bits (270), Expect = 3e-23
 Identities = 127/512 (24%), Positives = 231/512 (45%), Gaps = 62/512 (12%)

Query: 568  QVQLQCSP-AELQA---ELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ------H 617
            Q Q+Q  P A+ QA   +L   QA L E+E    K+E  +   +  + +++        +
Sbjct: 1257 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1316

Query: 618  QADLELIES-AHRSRIKVLETSYQQREERLRRENEELS----------ARYLSQCQEAEQ 666
            +A LE + S A + +++    S  Q    LR    EL+          +  L + +E E+
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376

Query: 667  ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAA 726
               +  A+ + RLA +    +++ + L E    +     R+ +E  QR++    R  +AA
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435

Query: 727  TSATSHTRSLNSIIHQMEKFSSSLHELSSR----VEASHLTTSQERELGIRQRDEQLRAL 782
              A    RS+   + Q+ + S +  +  +R     E S L   +E    IR    QL A 
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE----IRVVRLQLEAT 1491

Query: 783  QERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ 842
            + + G  + +++  R+R +      EA   ++    E ER R   +       Q  +E  
Sbjct: 1492 ERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1545

Query: 843  RKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAER 902
             +V A+      AE  R K   L+  + + L+  E  RRL     E + Q +++ E A+R
Sbjct: 1546 SRVKAE------AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1599

Query: 903  EAERALQVDTQREGTLISLAKEQAELK-------IRASELRAEEKQLAAERAALEQERQE 955
             AE  LQ          S A++ A+L+       +  ++LR E ++ A ++A  E+ R+E
Sbjct: 1600 SAEAELQ------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1653

Query: 956  LRLEKERINA---TALRVKLRAEEV---ESMSKVASEKY-EEGERALREAQQVQAEQQAR 1008
               E ER       ALR++L+AEEV   +S+++  +EK  EE ER  R   + + +   +
Sbjct: 1654 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1713

Query: 1009 LQAVQQQQERLRKQEQHMHQEHLSLAQQRLQL 1040
             +  +Q+ E+ R+  +   Q+ L+  Q+ ++L
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1745



 Score =  106 bits (264), Expect = 1e-22
 Identities = 135/556 (24%), Positives = 256/556 (46%), Gaps = 56/556 (10%)

Query: 551  ARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLL 610
            AR    + E +++   A+ ++Q S A  +      +A L E+E    K+E  R   E   
Sbjct: 1997 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2053

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSY----QQREERLRRENEELSARYLSQCQEAEQ 666
               +Q+    L+L + A + R++  E ++    QQ+E+ L++  ++  +       EAE 
Sbjct: 2054 -RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2112

Query: 667  ARAELTAQHQRRLAA--IAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVD 724
            AR       + R+ A   A +  +++E    L++++    +   + Q    KL K+ E +
Sbjct: 2113 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2172

Query: 725  AATSATSHTRSL------NSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR--- 775
            AA  A +   +L      ++ + + +KF+       ++VE    T   + E    Q+   
Sbjct: 2173 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232

Query: 776  DEQLRALQ---ERLGQQQRDMEEERSR---QQEVIGKMEARLNEQSR--LLEQERWRVTA 827
            DE+L+ L+       +Q+  +EEE      Q E + K++AR+  ++R  +L  +      
Sbjct: 2233 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2292

Query: 828  EQSKAESMQRALEEQRK--VTAQQMAMER--AELERAKS-ALLEEQKSVMLKCGEERRRL 882
             Q +AE M++  EE  +  V AQ+ A  R  AE + A+  AL E+     ++  +E  RL
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352

Query: 883  AAEWAEFSAQQKLSKERAER----EAERALQVDTQREG---TLISLAKEQAELKIRASEL 935
             AE      Q++L++E+A R    + + A Q+  + +G   TL +  + Q E+   A  L
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412

Query: 936  RAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEE----VESMSKVASEKYEEG 991
            +    +++  +A  E++ Q  R + E I     R +L  +E    V+++     +   + 
Sbjct: 2413 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2472

Query: 992  ERALREA------QQVQAEQQARLQAVQQ------QQERLRKQEQHMHQEHLSLAQQRLQ 1039
            ER LREA      ++ + +Q+A+L  ++       QQE+L ++ Q + Q  LS     LQ
Sbjct: 2473 ER-LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531

Query: 1040 LDRARQDLPSSLVGLF 1055
             +R  +   + L  LF
Sbjct: 2532 RERFIEQEKAKLEQLF 2547



 Score =  105 bits (261), Expect = 3e-22
 Identities = 127/515 (24%), Positives = 219/515 (42%), Gaps = 69/515 (13%)

Query: 568  QVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESA 627
            QV L+ +    +AEL   +A  AE  AQ+ +             SLQ++H A  +L E A
Sbjct: 1591 QVALETAQRSAEAELQSKRASFAEKTAQLER-------------SLQEEHVAVAQLREEA 1637

Query: 628  HRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD 687
             R          Q   ER R E E    R+  +  EA + R +     Q++  A A+ + 
Sbjct: 1638 ER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1691

Query: 688  QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATS-----ATSHTRSLNSIIHQ 742
            Q+ E  RE +R    + +   + +L   +L K R++   T+     A      L +   Q
Sbjct: 1692 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1751

Query: 743  MEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQE 802
             E+    L E  +R++      +Q+R+    +  +    ++  L  + R  EE RS  ++
Sbjct: 1752 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1811

Query: 803  VIGKMEARLNEQSRLLEQE-RWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERA- 860
               ++EA       L E+  R R  AE++K          QR++  +  A +RAE ER  
Sbjct: 1812 SKQRLEAEAGRFRELAEEAARLRALAEEAK---------RQRQLAEEDAARQRAEAERVL 1862

Query: 861  --------KSALLEEQKSVMLKC----GEERRRLAAEWA-------EFSAQQKLSKERAE 901
                    ++  L+ +  + LK      E  RRLA + A       E +AQ K   E   
Sbjct: 1863 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1922

Query: 902  REAERALQVDTQREGTLIS-LAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLE- 959
             +  +A   + +R+  L+    +++ +++     L+A  ++ AA +A LE E   +R   
Sbjct: 1923 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1982

Query: 960  ------KERINATALRVKLRAEEVESMSKVASEKYEEGERALREA---QQVQAEQQARLQ 1010
                  KE+    A R +  A E E   + A E+ ++   A  EA   ++   E+  RL+
Sbjct: 1983 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2042

Query: 1011 AVQQQQERLRKQEQHMHQEHLSLAQQ----RLQLD 1041
            A  ++  RLR++ +      L LAQ+    RLQ +
Sbjct: 2043 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077



 Score =  103 bits (258), Expect = 7e-22
 Identities = 133/554 (24%), Positives = 245/554 (44%), Gaps = 78/554 (14%)

Query: 559  EYQKQLLAAQVQLQ---CSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLG---- 611
            + ++++LA +   +      AEL+ EL   ++   +      + ELE A+   L      
Sbjct: 1949 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2008

Query: 612  ---SLQQQHQADLELIESAHRSRIKVLE-----TSYQQREERLRRENEELSARYLSQCQE 663
                 +++ Q  L   E A R R   LE      +  +   RLR   E+ SAR L   QE
Sbjct: 2009 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2068

Query: 664  AEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQR-LKLLKDRE 722
            A Q R  L A+ +    A+ Q+K+QE+++  + Q  S+LD  R   E  +R  +  ++  
Sbjct: 2069 AAQKR--LQAEEKAHAFAV-QQKEQELQQTLQ-QEQSVLDQLRGEAEAARRAAEEAEEAR 2124

Query: 723  VDAATSATSHTRSLNSIIHQMEKFSSSLHE-----LSSRVEASHLTTSQERELGIRQRDE 777
            V A   A    R     + + E+   S  E       ++  A  L    E+E   R + E
Sbjct: 2125 VQAEREAAQSRRQ----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2180

Query: 778  QLRALQERLGQQQRDMEE--------ERSRQQEVIGKMEARLNE---QSRLLEQERWRVT 826
            Q    Q++    + +  +        ++++ ++ +  +  +L E   Q  LL++E  R+ 
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2240

Query: 827  AEQSKAESMQRALEEQR---KVTAQQMAMERAELERAKSAL-----------LEEQKSVM 872
            AE ++A   +  +EE+    +V  ++++  +A +E    AL           L+E+   M
Sbjct: 2241 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2300

Query: 873  LKCGEERRRL--AAEWA--------EFSAQQKLSKERAEREAERALQVDTQREGTLISLA 922
             +  EE  RL  AA+ A        E  AQQ+   E+  +E  +A+Q  T+ +     L 
Sbjct: 2301 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELL 2359

Query: 923  KEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKER-----INATALRVKLRAEEV 977
            ++Q EL    +    E+K+  A++ A E +  +  LE ER     ++A A R+KLR  E 
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE- 2418

Query: 978  ESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQ----ERLRKQEQHMHQEHLSL 1033
              MS+  +   E+ +R  ++A+++  E+  R +   Q++    + L  Q Q    +   L
Sbjct: 2419 --MSRAQARAEEDAQRFRKQAEEI-GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475

Query: 1034 AQQRLQLDRARQDL 1047
             +   +L+R ++ L
Sbjct: 2476 REAIAELEREKEKL 2489



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 140/533 (26%), Positives = 239/533 (44%), Gaps = 74/533 (13%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            QK L  A+ + Q   AE +A         A  + ++ + ELE+ Q +L  G+ QQ+  A+
Sbjct: 1681 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAE 1739

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLA 680
             ELI    R+  +  E   Q  EE L R   E +A    + QE E   A++ A+ +  LA
Sbjct: 1740 QELIRL--RAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLA 1796

Query: 681  AIAQEKDQEMERLRELQRASILDMRRDHE--EQLQRLKLLKDR--------EVDAATSAT 730
            + A+ +++      + ++    +  R  E  E+  RL+ L +         E DAA    
Sbjct: 1797 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1856

Query: 731  SHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRD---EQLRALQERLG 787
               R L               +L++  EA+ L T  E E+ +++++   E+LR L E   
Sbjct: 1857 EAERVL-------------AEKLAAIGEATRLKT--EAEIALKEKEAENERLRRLAEDEA 1901

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ---RK 844
             Q+R +EE+ ++ +  I +  A+L + S   E ER +   E +  +  +R +EE+    K
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDS-ELERQKGLVEDTLRQ--RRQVEEEILALK 1958

Query: 845  VTAQQMAMERAELE--------------RAKS-ALLEEQKSVMLKCGEERRR-------- 881
             + ++ A  +AELE              R+K  A LE  +   L   EERRR        
Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2018

Query: 882  --LAAEWAEFSAQQKLSKERAER------EAERALQVDTQREGTLISLAKEQAELKIRAS 933
              LAAE  E + Q+K + E  ER      EA R  +   Q     + LA+E A+ +++A 
Sbjct: 2019 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077

Query: 934  ELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGER 993
            E +A    +  +   L+Q  Q+ +   +++   A   +  AEE E     A  +  +  R
Sbjct: 2078 E-KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2136

Query: 994  ALREAQQVQ--AEQQARLQA-VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRA 1043
             + EA++++  AE+QA+ +A  Q   E+LRK+ +          Q  L+  +A
Sbjct: 2137 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 149/642 (23%), Positives = 264/642 (41%), Gaps = 160/642 (24%)

Query: 559  EYQKQLLAAQVQLQCSPAE--LQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ 616
            E  +Q  A Q+QL    A+  LQAE    +A    ++ + ++L+    Q + +L  L+ +
Sbjct: 2053 ERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2109

Query: 617  HQADLELIESAHRSRIKVLETSYQQRE-----ERLRRENEELS-ARYLSQC------QEA 664
             +A     E A  +R++    + Q R      ERL++  EE + AR  +Q       +EA
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2169

Query: 665  EQ-----ARAELTAQHQRRLAAIAQEKDQEMERLRELQRASI--------LDMRR-DHEE 710
            EQ     A+AE  A  Q++ A    EK ++       Q+A +        L +   DH++
Sbjct: 2170 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2229

Query: 711  QL--QRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
             L  + L+ LK    +AA   +     L S+  QME+ S    +L +R+EA      + R
Sbjct: 2230 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS----KLKARIEA------ENR 2279

Query: 769  ELGIRQRDEQLRALQERLGQQQ-------------------RDMEEERSRQQEVIG---- 805
             L +R +D   R LQE   + +                   R + EE   QQ  +     
Sbjct: 2280 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2339

Query: 806  --KMEA-----RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELE 858
              KM+A     RL  ++ LL+Q++         A+   R L+E ++  AQQ+A E    +
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQK-------ELAQEQARRLQEDKEQMAQQLAEETQGFQ 2392

Query: 859  RAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVD------- 911
            R     LE ++   L+   E  RL    AE S  Q  ++E A+R  ++A ++        
Sbjct: 2393 RT----LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2448

Query: 912  --TQREGTLISLA------------------------KEQAELKIRASELRAEEKQ---- 941
              TQ + TL+                           KE+ + + +  +L++EE Q    
Sbjct: 2449 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2508

Query: 942  ---------------------------LAAERAALEQ-------ERQELRLEKERINATA 967
                                       +  E+A LEQ       + Q+LR E++R     
Sbjct: 2509 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2568

Query: 968  LRVKLRAEEVESMSKVASEKYEEGE---RALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024
             + + R   V SM +    ++E  E   R   E QQ++ +++ + + + ++ +RLR+Q Q
Sbjct: 2569 EQERQRL--VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626

Query: 1025 HMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQ 1066
             + ++H +      ++  ++     +L        GPAA ++
Sbjct: 2627 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2668



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 125/546 (22%), Positives = 243/546 (44%), Gaps = 76/546 (13%)

Query: 560  YQKQLLAAQV------QLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSL 613
            +++QL  AQ       +L+ + A L+   L +QA   +      + EL  AQ    +G  
Sbjct: 1135 HEEQLKEAQAVPATLPELEATKASLKK--LRAQAEAQQPTFDALRDELRGAQE---VGER 1189

Query: 614  QQQHQADLELIESAHRSRIKVL---------ETSYQQRE-ERLRRE-------NEELSA- 655
             QQ   + ++     R R+  L         +T  +QRE E+L R+        + L A 
Sbjct: 1190 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1249

Query: 656  -----RYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRAS--ILDMRRDH 708
                 R   Q Q    A ++   +  R+  A+ +E ++  E++ E QR +   ++  +D+
Sbjct: 1250 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309

Query: 709  EEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
            E QL   K   +     A      + S  S+I +     +   EL++        TSQ  
Sbjct: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTT-------LTSQY- 1360

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAE 828
               I+   E LR ++E    ++R  E++R+ ++E + ++EA L +Q +L E         
Sbjct: 1361 ---IKFISETLRRMEE----EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1413

Query: 829  QSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEE--QKSVMLKCGEERRRLAAEW 886
            + +A+ +Q+ ++E+  V  ++ A++  + +R+    L++  Q S      + R+  AAE 
Sbjct: 1414 EREAKELQQRMQEE-VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1472

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAE-------- 938
            +    ++++   R + EA    +   + E   +    E+AE + R ++  AE        
Sbjct: 1473 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1532

Query: 939  ----EKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVAS-EKYEEGER 993
                ++Q   E A+  +   E   EK+R       ++L+AEE E   + A  E+  + + 
Sbjct: 1533 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1592

Query: 994  ALREAQQ-VQAEQQARLQAVQQQQERLRK--QEQHMH-----QEHLSLAQQRLQLDRARQ 1045
            AL  AQ+  +AE Q++  +  ++  +L +  QE+H+      +E    AQQ+ + +RAR+
Sbjct: 1593 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1652

Query: 1046 DLPSSL 1051
            +    L
Sbjct: 1653 EAEREL 1658



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 93/427 (21%), Positives = 162/427 (37%), Gaps = 71/427 (16%)

Query: 662  QEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDR 721
            QEA++A   L AQHQ  L  +  +   +M+ L   Q      +RRD       ++L+  R
Sbjct: 890  QEAQEAVTRLEAQHQA-LVTLWHQLHVDMKSLLAWQ-----SLRRD-------VQLI--R 934

Query: 722  EVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRA 781
                AT  T         +H +E    +   L    +A      ++R +  R+       
Sbjct: 935  SWSLATFRTLKPEEQRQALHSLELHYQAF--LRDSQDAGGFGP-EDRLMAEREYGSCSHH 991

Query: 782  LQERLGQQQRDMEEERSRQQEVIGKMEARLN-EQSRLLEQERWRVTAEQSKAESMQRALE 840
             Q+ L   ++  +EE   Q+ +    + RL  E        R R+  ++  A    + + 
Sbjct: 992  YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1051

Query: 841  EQRKVTAQQMAMER------AELERA--------KSALLEEQKSVMLKCGEERRRLAAEW 886
            EQ+K  A+   + +      AE E+          +  L  +  + L   E+ R L+A +
Sbjct: 1052 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1111

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQR--------------EGTLISLAKEQAELKIR- 931
             E      L   R  + AE  L+   ++              E T  SL K +A+ + + 
Sbjct: 1112 LEKLKTISLVI-RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1170

Query: 932  ------------ASELRAEEKQLAAER-AALEQERQELRLEKERINATALRVKLRAEEVE 978
                        A E+    +Q   ER   +E+ R+ +    ER  A   +  +R  E+E
Sbjct: 1171 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1230

Query: 979  SMSKVASEKYEEG-------ERALREAQQVQAEQQARLQAVQQQ--QERLRKQEQHMHQE 1029
             + +      E         + A R  +Q+QA   A  QAV++Q  QE+   +E   H E
Sbjct: 1231 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1290

Query: 1030 HLSLAQQ 1036
             +   Q+
Sbjct: 1291 KVEECQR 1297


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
            [Homo sapiens]
          Length = 828

 Score =  109 bits (272), Expect = 2e-23
 Identities = 91/493 (18%), Positives = 235/493 (47%), Gaps = 30/493 (6%)

Query: 570  QLQCSPAELQAELLHSQARLAELEAQVRKLE--LERAQH---ELLLGSLQQQHQADLELI 624
            +L+   AELQ +L  +++  +E++  V++L+  LERA+    ++   +LQ++     E +
Sbjct: 184  ELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEEL 243

Query: 625  ESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQ 684
                + +I+  E    ++EERLR +  ++  +     ++ ++ R +     ++      Q
Sbjct: 244  REQEK-KIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQ 302

Query: 685  EKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQME 744
            +K +E E   + Q   + +      EQ +++   ++R  +         + +     +M 
Sbjct: 303  KKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 362

Query: 745  KFSSSLHELSSRVEASHLTTSQ-----------ERELGIRQRDEQLRALQERLGQQQRDM 793
            +    L E   R+        Q           ERE  +R+ +E +R  +E++ +Q+ +M
Sbjct: 363  EQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 422

Query: 794  --EEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMA 851
              +EE+  QQ+ + + + +L EQ ++ EQE  ++  ++ K    +    +++K+  Q+  
Sbjct: 423  WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE-KIWEQEEKIRDQEEMWGQEKKMWRQEKM 481

Query: 852  MERAELERAKSALLEEQKSVML----KCGEERRRLAAEWAEFSAQQKLSKERAEREAERA 907
             E+ +    +   + +Q+  M     +  E+  RL  +      Q+K+ ++  +   E+ 
Sbjct: 482  REQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKK 541

Query: 908  LQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATA 967
             Q   ++        +E+  ++ R  ++R EE+ +  +   ++++ +++R ++E++    
Sbjct: 542  TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQE 601

Query: 968  LRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQ----QQQERLRKQE 1023
             +++ + E++    +   E+ EE +  ++E +++  EQ+ ++Q  +    +Q+E++R+QE
Sbjct: 602  EKMQEQEEKMWEQEEKMWEQEEEDK--MQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQE 659

Query: 1024 QHMHQEHLSLAQQ 1036
            + M ++   +  Q
Sbjct: 660  EKMREQEEKMQGQ 672



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 92/492 (18%), Positives = 234/492 (47%), Gaps = 41/492 (8%)

Query: 577  ELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKV-- 634
            E + ++   + RL E E ++R+ E E  + + L    +Q  + + ++ E   + R +   
Sbjct: 273  EQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEK 332

Query: 635  ---LETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEME 691
                E    ++E+++R + +++  +     ++ E+ R +     ++      +EK QE E
Sbjct: 333  MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEE 392

Query: 692  RLRELQRA--SILDMRRDHEEQLQRLK--LLKDREVDAATSATSHTRSLNSIIHQMEKFS 747
            R+RE ++      +  R+ EE++Q+ +  + +  E +         +       +M++  
Sbjct: 393  RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE 452

Query: 748  SSLHELSSRVEASHLTTSQERELG----IRQRDEQLRALQERLGQQQR---DMEEERSRQ 800
              + E   ++        QE+++     +R++++Q+   +E++  Q++   D EE    Q
Sbjct: 453  EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512

Query: 801  QEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERA 860
             E + + E R+ EQ ++ +QE  ++  E+   E  ++  +++ K+  ++   ER +  R 
Sbjct: 513  DERLREKEERMREQKKMWQQEE-KMREEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 571

Query: 861  KSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLIS 920
            +  ++ EQ+    K  E+  ++  +  +   Q++  +E+ E+  E+  ++  Q E   + 
Sbjct: 572  EEEMMREQEE---KMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKM- 627

Query: 921  LAKEQAELKIRASE-LRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVES 979
              +EQ E+     E ++ +E+++  +   + ++ +++R ++E++       K+R +E   
Sbjct: 628  --QEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ--EEKMREQE--- 680

Query: 980  MSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHM-HQEHLSLAQQRL 1038
                  EK +  E  +RE ++    Q+ ++     Q+E++  QE+ M  QE +   ++R+
Sbjct: 681  ------EKMQGQEEKMREQEEKMRGQEEKMWG---QEEKMWGQEEKMWGQEEMREKEERI 731

Query: 1039 --QLDRARQDLP 1048
              Q ++ ++ LP
Sbjct: 732  RDQKEKMQERLP 743



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 78/367 (21%), Positives = 170/367 (46%), Gaps = 46/367 (12%)

Query: 704  MRRDHEEQLQRLKLLKDREVDAATSA--------------TSHTRSLNSIIHQMEKFSSS 749
            +RR+ E Q   +++L  ++ +  T+                  ++ L   +H    F+  
Sbjct: 83   LRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDLAGRLHHSWHFAGE 142

Query: 750  LHELSSRVEASHLTTSQERELGIRQRD-------------EQLRALQERLGQQQRDMEEE 796
            L    S V   H    +  E   ++RD             E+L+     L ++ R  E E
Sbjct: 143  LQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESE 202

Query: 797  RSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAE 856
            +S  Q  + +++ +L     LL Q +     E+   +  +   E+++K+  Q+  M R E
Sbjct: 203  KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQE 261

Query: 857  LE-RAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQK-LSKERAEREAERALQVDTQR 914
               R +   + EQ+  M +   + +RL  +  E   Q+K L +++  RE E  +Q   ++
Sbjct: 262  ERLREQEGKMREQEEKMRR---QEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEK 318

Query: 915  EGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRA 974
                  + +++ +++ +  ++  +E++L  +   + ++ Q++R ++ER+     R++ + 
Sbjct: 319  ------MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE 372

Query: 975  EEVESMSKV--ASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHM-HQEHL 1031
            E +    K+    EK +E ER +RE ++   E++   + +++Q+E+++KQE++M  QE  
Sbjct: 373  ERMREQEKMWEQEEKMQEEER-IREREKKMREEE---ETMREQEEKMQKQEENMWEQEEK 428

Query: 1032 SLAQQRL 1038
               QQRL
Sbjct: 429  EWQQQRL 435



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 91/426 (21%), Positives = 182/426 (42%), Gaps = 48/426 (11%)

Query: 641  QREERLRRENE--ELSARYLSQCQEAEQARAELTAQHQRRL---AAIAQEKD------QE 689
            Q +E LRRE E  + + R L+ CQ+ E   A   +Q   R      + + KD        
Sbjct: 78   QHQEALRREIEAQDHTIRILT-CQKTELETALYYSQDAARKFEDGNLGESKDLAGRLHHS 136

Query: 690  MERLRELQRA--SILDMRRDHEEQLQRLKLLKDR---EVDAATSATSHTRSLNSIIHQME 744
                 ELQRA  ++    +  +  ++ L   +D    E+   T      +  N+ + +  
Sbjct: 137  WHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL 196

Query: 745  KFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSR---QQ 801
            + + S  +   ++    L    ER   +  +  Q   LQE + +Q+ ++ E+  +   Q+
Sbjct: 197  RLAES-EKSEIQLNVKELKRKLERAKFLLPQ-VQTNTLQEEMWRQEEELREQEKKIRKQE 254

Query: 802  EVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAK 861
            E + + E RL EQ   + ++  ++  ++ +    ++ L EQ K   +Q  +   E +   
Sbjct: 255  EKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQ--- 311

Query: 862  SALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISL 921
               ++EQ+  M +  EE+ R   E      ++   +E+  RE E+ ++   +R      +
Sbjct: 312  ---MQEQEEKMWE-QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER------M 361

Query: 922  AKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMS 981
             ++   L+ +   +R +EK    E    E+ER   R +K R     +R     E+ E M 
Sbjct: 362  WEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMR-----EQEEKMQ 416

Query: 982  KVASEKYEEGERAL--------REAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSL 1033
            K     +E+ E+          +E    Q + Q + + + +Q+E++R QE+   QE    
Sbjct: 417  KQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMW 476

Query: 1034 AQQRLQ 1039
             Q++++
Sbjct: 477  RQEKMR 482



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 95/436 (21%), Positives = 182/436 (41%), Gaps = 47/436 (10%)

Query: 559 EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLEL-----ERAQHELLLGSL 613
           E +KQ+   + +++    + +  +     RL E E ++R+ E      E+ Q E  +   
Sbjct: 342 EQEKQMREQEQKMR----DQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER 397

Query: 614 QQQHQADLELIESAHRSRIKVLETSYQQRE-----ERLRRENEELSARYLSQCQEAEQAR 668
           +++ + + E +        K  E  ++Q E     +RL  + E+L  +   Q QE +   
Sbjct: 398 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 457

Query: 669 AELTAQHQRRLAAIAQEKD---QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDA 725
            E   + Q  +    QEK    QE  R +E Q     +  RD E+++   +     + + 
Sbjct: 458 QEEKIRDQEEMWG--QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDER 515

Query: 726 ATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQER 785
                   R    +  Q EK    + E     E    T  QE ++   + +E++R  +++
Sbjct: 516 LREKEERMREQKKMWQQEEK----MREEKKTQEQEKKTWDQEEKM---REEERMREREKK 568

Query: 786 LGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKV 845
           + +++  M E+  + QE   KM     ++ ++ EQE      E+   E  ++  E++ + 
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMR---EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625

Query: 846 TAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAE 905
             Q    E+ E+   +   ++EQ+  M +  EE+ R   E      ++   +E   RE E
Sbjct: 626 KMQ----EQEEMMWEQEEKMQEQEEKMWE-QEEKMREQEEKMREQEEKMQGQEEKMREQE 680

Query: 906 RALQVDTQREGTLISLAKEQAELKIRASELR---AEEKQLAAERAALEQERQELRLEKER 962
             +Q   ++        +EQ E K+R  E +    EEK    E     QE  E+R ++ER
Sbjct: 681 EKMQGQEEK-------MREQEE-KMRGQEEKMWGQEEKMWGQEEKMWGQE--EMREKEER 730

Query: 963 INATALRVKLRAEEVE 978
           I     +++ R  E E
Sbjct: 731 IRDQKEKMQERLPEHE 746



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 69/309 (22%), Positives = 131/309 (42%), Gaps = 25/309 (8%)

Query: 747  SSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGK 806
            S   H      +ASH      R   I  +D  +R L      Q+ ++E      Q+   K
Sbjct: 63   SEGCHSPEDEKKASHQHQEALRR-EIEAQDHTIRILT----CQKTELETALYYSQDAARK 117

Query: 807  ME-ARLNEQSRLLEQ--ERWRVTAEQSKAESMQRALEEQRKVTAQQMAMER--AELERAK 861
             E   L E   L  +    W    E  +A S      ++     +++  ER    LE  +
Sbjct: 118  FEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYR 177

Query: 862  SALL-EEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLIS 920
            + +  EE K    +  E+ R   +E +E     K  K + ER      QV T    TL  
Sbjct: 178  NTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTN---TL-- 232

Query: 921  LAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESM 980
                Q E+  +  ELR +EK++  +   + ++ + LR ++ ++     +++ + + +   
Sbjct: 233  ----QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQ 288

Query: 981  SKVASEKYEE--GERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRL 1038
             K   E+ +E   ++ LRE ++   EQ+ ++    +Q+E++R+QE+ M ++   L +Q  
Sbjct: 289  EKELREQEKELREQKKLREQEEQMQEQEEKM---WEQEEKMREQEEKMWRQEERLWEQEK 345

Query: 1039 QLDRARQDL 1047
            Q+    Q +
Sbjct: 346  QMREQEQKM 354



 Score = 37.4 bits (85), Expect = 0.081
 Identities = 35/232 (15%), Positives = 99/232 (42%), Gaps = 15/232 (6%)

Query: 581 ELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSR-----IKVL 635
           E +  Q ++ + E ++R+ E +  + E      +++ + +  + E   + R     ++  
Sbjct: 521 ERMREQKKMWQQEEKMRE-EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQ 579

Query: 636 ETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRE 695
           E   Q++EE++R + E++      Q ++ ++   ++  Q ++      ++K QE E +  
Sbjct: 580 EEKMQEQEEKMREQEEKM----WEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMW 635

Query: 696 LQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSS 755
            Q   + +      EQ ++++  +++  +           +     +M+     + E   
Sbjct: 636 EQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEE 695

Query: 756 RVEASH--LTTSQERELGIRQR---DEQLRALQERLGQQQRDMEEERSRQQE 802
           ++      +   +E+  G  ++    E++R  +ER+  Q+  M+E     +E
Sbjct: 696 KMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEE 747


>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
          Length = 1476

 Score =  108 bits (270), Expect = 3e-23
 Identities = 199/840 (23%), Positives = 323/840 (38%), Gaps = 176/840 (20%)

Query: 359  PTREAHRESSV-PVTPSVP--PPASQHSTPAGL---------------PPS-------RA 393
            P  EA RE  V PV    P  P A  HS P GL               PP+        A
Sbjct: 487  PLLEAPREDPVLPVLEEAPQTPVAFDHS-PQGLVQKARDGGPQALDLAPPALDSVLEASA 545

Query: 394  KPPTEGAGSPAKASQASKLRASKEEKEDWLSHALSRKKSQGLAREQHAGTSEGLHLAGTA 453
            + P      P +A    +  A   +  DW S   S    +     + AG    L    + 
Sbjct: 546  ECPQAPDSDPQEAESPLQAAAMDPQASDW-SPQESGSPVETQESPEKAGRRSSLQSPASV 604

Query: 454  GHPPSGSQPLTSTQGLEHAAAGGSSGTTA-------------RERPCVRPGVSGSPVTQN 500
              PP G  P T  Q  +    G + G  A             +E P  +PG S     Q 
Sbjct: 605  A-PPQG--PGTKIQAPQ-LLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQL 660

Query: 501  HAASA------LPTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSVPVQ----PLLPESL 550
                       L TG  +       L  T     +   Q+ +E ++ VQ    P+  ESL
Sbjct: 661  EEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESL 720

Query: 551  ARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLL 610
            A  +           A Q  L+   A+L+ +   ++A   ELEAQ RKLE +  +   L 
Sbjct: 721  ASGV-----------AEQEALREEVAQLRRK---AEALGDELEAQARKLEAQNTEAARLS 766

Query: 611  GSLQQQHQADLELIESAH-----RSRIKV--------LETSYQQREE---------RLRR 648
              L Q  +A+ E    A      ++R++         LE++ Q+RE          R RR
Sbjct: 767  KELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERR 826

Query: 649  ENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQ------EMERL--------- 693
            + E   +R  +Q + AE+    L ++ ++ L    +E+ +      E+E+          
Sbjct: 827  QWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGA 886

Query: 694  ------RELQRASI--LDMRRDHEEQLQRLKLLKDR-EVDAATSATSHTRSLNSIIHQME 744
                  REL++A++   +  R+ E Q QR + L+ R E +   +ATS   +L  +  +  
Sbjct: 887  RLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRAL 946

Query: 745  KFSSSLHEL---------SSRVEASHLTTSQERELGIRQRDE-----------QLRALQE 784
            +    L +L           R E   + T   R + + + +            QL+ L+ 
Sbjct: 947  QLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEG 1006

Query: 785  RLGQQQRDMEE---ERSRQQEVIGKMEAR----------LNEQSRLLEQERWRVTAEQSK 831
            +LG  Q   +E   +  R QE   +++A           L+ +  +LE+E       Q +
Sbjct: 1007 QLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEE 1066

Query: 832  AESMQRALEEQRKVTAQQMAMERAELE------RAKSALLEEQKSVMLKCGEERRRLAAE 885
                Q+AL    K  AQ    + AELE      R   A +   +    +      +L A+
Sbjct: 1067 TRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQ 1126

Query: 886  WAEFSAQ------------QKLSKERAEREAERALQVDTQREGTLIS-LAKEQAELKIRA 932
             A   AQ            Q   ++R   E  R LQ +  R   L++ L++E+ EL+   
Sbjct: 1127 RASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGER 1186

Query: 933  SELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGE 992
             ELR    +L  ERA LE + Q+LR   ++++ +A R+     + E ++++ S + EE  
Sbjct: 1187 GELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRL---TTQCELLTQLRSAQEEENR 1243

Query: 993  RALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSLV 1052
            + L E Q +  E +  L       ER  +   H+H+E      Q   L R +Q L   ++
Sbjct: 1244 QLLAEVQALSRENRELL-------ERSLESRDHLHREQREYLDQLNALRREKQKLVEKIM 1296



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 62/219 (28%), Positives = 94/219 (42%), Gaps = 14/219 (6%)

Query: 839  LEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKE 898
            L  +R + AQ++A     LER    L  E  S     G     LA + A   AQ +  ++
Sbjct: 216  LARERDLGAQRLA--ELLLEREPLCLRPEAPSRAPAEGPSHH-LALQLANAKAQLRRLRQ 272

Query: 899  RAEREAERALQVDTQREGTLISLAKEQAELKI-----RASELRAEEKQLAAERAA-LEQE 952
              E +AE  L    + +G    + + + E +      + +EL  EE +   ERA  L + 
Sbjct: 273  ELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRL 332

Query: 953  RQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAV 1012
            ++ELR  +ER+ A A   K + EE     +V S   E  +  L E  +   E+ ARL   
Sbjct: 333  QEELRRCRERLQA-AEAYKSQLEE----ERVLSGVLEASKALLEEQLEAARERCARLHET 387

Query: 1013 QQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSL 1051
            Q++   LR +    H E  SL  Q  QL     +L   L
Sbjct: 388  QRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELEL 426



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 66/254 (25%), Positives = 102/254 (40%), Gaps = 28/254 (11%)

Query: 765  SQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWR 824
            S    L +     QLR L++ L ++   + +    Q EV G     L  + R L QE   
Sbjct: 253  SHHLALQLANAKAQLRRLRQELEEKAELLLDS---QAEVQG-----LEAEIRRLRQEAQA 304

Query: 825  VTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSAL--LEEQKSVMLKCGEERRRL 882
            ++ +  +AE  +   E  R+  A ++   + EL R +  L   E  KS +    EE R L
Sbjct: 305  LSGQAKRAELYREEAEALRE-RAGRLPRLQEELRRCRERLQAAEAYKSQL----EEERVL 359

Query: 883  AAEWAEFSAQQKLSKERAEREAERALQV-DTQREGTLISLAKEQAELKIRASELRAEEKQ 941
            +       A + L +E+ E   ER  ++ +TQRE  L         L+ R  E  AE   
Sbjct: 360  S---GVLEASKALLEEQLEAARERCARLHETQRENLL---------LRTRLGEAHAELDS 407

Query: 942  LAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQV 1001
            L  +   L +E  EL LE +R           A    +   +  E  E     LR  ++ 
Sbjct: 408  LRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERE 467

Query: 1002 QAEQQARLQAVQQQ 1015
              E +  LQ +Q Q
Sbjct: 468  NRELRGLLQVLQGQ 481



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 55/236 (23%), Positives = 99/236 (41%), Gaps = 20/236 (8%)

Query: 572 QCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGS----LQQQHQADLELIESA 627
           + +PAEL+         L++L A+ R L  +R   ELLL      L+ +  +       +
Sbjct: 196 ELAPAELEMLSRSLMGTLSKL-ARERDLGAQRLA-ELLLEREPLCLRPEAPSRAPAEGPS 253

Query: 628 HRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD 687
           H   +++     Q R  RLR+E EE +   L    E +   AE+    Q   A   Q K 
Sbjct: 254 HHLALQLANAKAQLR--RLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKR 311

Query: 688 QEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFS 747
            E+ R    + A  L   R+   +L RL+    R  +   +A ++   L     + E+  
Sbjct: 312 AELYR----EEAEAL---RERAGRLPRLQEELRRCRERLQAAEAYKSQL-----EEERVL 359

Query: 748 SSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEV 803
           S + E S  +    L  ++ER   + +   +   L+ RLG+   +++  R +  ++
Sbjct: 360 SGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQL 415



 Score = 32.3 bits (72), Expect = 2.6
 Identities = 48/188 (25%), Positives = 73/188 (38%), Gaps = 37/188 (19%)

Query: 893  QKLSKERAEREAERALQVDTQREGTLISLAKEQ------AELKIRASELRAEEKQLAAER 946
            Q LS E     A    +V     G +++L+         AEL++ +  L     +LA ER
Sbjct: 161  QGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARER 220

Query: 947  AALEQERQELRLEKERI------------------------NATALRVKLRAEEVESMSK 982
                Q   EL LE+E +                        NA A   +LR E  E    
Sbjct: 221  DLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAEL 280

Query: 983  VASEKYE----EGE-RALREAQQVQAEQQARLQAVQQQQERLRKQEQHMH--QEHLSLAQ 1035
            +   + E    E E R LR+  Q  + Q  R +  +++ E LR++   +   QE L   +
Sbjct: 281  LLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCR 340

Query: 1036 QRLQLDRA 1043
            +RLQ   A
Sbjct: 341  ERLQAAEA 348


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  106 bits (264), Expect = 1e-22
 Identities = 129/521 (24%), Positives = 249/521 (47%), Gaps = 46/521 (8%)

Query: 552  RSLLPSTEYQKQLLAAQVQ-LQCSPAELQAELLHSQARLAELEAQVRKLE----LERAQH 606
            R    + + Q +L  AQ + LQ + A L   L   +  +  L  Q+++LE    +++A  
Sbjct: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAAL 1458

Query: 607  ELLLGSLQQQHQ-ADL--ELIESAHRSR--IKVLETSYQQREERLRRENEELSARYLSQC 661
            ELL   L++++Q  DL  E I+   + R  ++ L  + Q+RE++L  + E++  R L + 
Sbjct: 1459 ELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI--RELEKD 1516

Query: 662  QEAEQARAE---LTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLL 718
            +E ++   E   L  + + ++    + + Q++++         L++  +H +   + KL+
Sbjct: 1517 RETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLI 1576

Query: 719  KDREVDAATS--ATSH-TRSLNSIIHQMEKFSSSLHELSSR--VEASHLTTSQERELGIR 773
            K+ E    T   A +H T  L     +++  SS +H+L S   V A  L   QER+  ++
Sbjct: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAREL---QERDQEVK 1633

Query: 774  QRDEQLRALQ---ERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTA--- 827
             + EQ+  LQ   E L Q     ++E   Q+E I  +E +   Q+++LE++  ++     
Sbjct: 1634 SQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLR 1693

Query: 828  EQSKAESMQRALEEQRKVTAQQMAM-ERAELERAKSALLEEQKSVMLKCGEERRRLAAEW 886
            E+ +  + QR L ++R    +  +  +R  LE  K  L +++K V  +C +E      E 
Sbjct: 1694 ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEV--ECQQEHIHELQEL 1751

Query: 887  AEFSAQQKLSKERAEREAERALQVDTQREGTLISL------AKEQAELKIRASELRAEEK 940
             +   QQ     R   E    L   +QRE  ++ L      A+EQ ELK ++ + + +E 
Sbjct: 1752 KDQLEQQLQGLHRKVGETSLLL---SQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808

Query: 941  QLAA-----ERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERAL 995
            Q A      E  AL+QE+Q+ + ++ER+   A  ++   E+     K    + ++ +   
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA 1868

Query: 996  REAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQ 1036
            R  ++  A +  R+QA+++    LR + +   +  L+L QQ
Sbjct: 1869 RRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQ 1909



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 129/484 (26%), Positives = 204/484 (42%), Gaps = 44/484 (9%)

Query: 577  ELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIK--- 633
            E Q  +L  Q  L ELE + + +E +R Q + L   L       LEL E+ H+   +   
Sbjct: 1518 ETQRNVLEHQ--LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL 1575

Query: 634  VLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEM--- 690
            + E   Q+  +R+   +  L     SQ  +A+ ++      H   LA   QE+DQE+   
Sbjct: 1576 IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQ 1635

Query: 691  -ERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSS 749
             E++ ELQR     + +D E + Q L L K+R        T  T+ L   + Q++     
Sbjct: 1636 REQIEELQRQKE-HLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIK----- 1689

Query: 750  LHELSSRVEASHLTTS----QERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIG 805
               LS R     LTT     QER    +   +  R   E +    RD E+E   QQE I 
Sbjct: 1690 ---LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746

Query: 806  KMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALL 865
            +++  L +Q     Q   R   E S   S +    EQ  V  QQ   E  E    K   L
Sbjct: 1747 ELQ-ELKDQLEQQLQGLHRKVGETSLLLSQR----EQEIVVLQQQLQEAREQGELKEQSL 1801

Query: 866  EEQKSVMLKCGEERRRLAAEWAEFSA---QQKLSKERAEREAERALQVDTQREGTLISLA 922
            + Q        E +R LA    E  A   +Q+ ++ + ER  E+A  +    E   ++L 
Sbjct: 1802 QSQLD------EAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855

Query: 923  KEQAELKIRASELRAEEKQLAAERA---ALEQERQELRLEKERINATALRVKLR----AE 975
            +   EL+    + R  E++LA E     ALE+   +LR E        L ++ +    A+
Sbjct: 1856 ERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915

Query: 976  EVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQ 1035
            E E  ++   + + + +  L+E  Q     +A  Q+ + Q+E  R + + + QE L  A 
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEAL-QEALGKAH 1974

Query: 1036 QRLQ 1039
              LQ
Sbjct: 1975 AALQ 1978



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 126/525 (24%), Positives = 231/525 (44%), Gaps = 61/525 (11%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            Q+QL  A+ Q +     LQ++L  +Q  LA+ + ++  L+ E+ Q +     ++++  A 
Sbjct: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADAL 1843

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQH----- 675
               +E AH + +K      Q  +E+ RR  EEL+     + Q  E+   +L A+      
Sbjct: 1844 QGALEQAHMT-LKERHGELQDHKEQARRLEEELAVEG-RRVQALEEVLGDLRAESREQEK 1901

Query: 676  -----QRRLAAIAQEKDQEMERLRE--LQRASILDMRRDHEEQLQRLKLLKDREVDAATS 728
                 Q++ A  AQE + E   L++  LQ  ++L   RD E +  R +    R  + A  
Sbjct: 1902 ALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLK-ERDQELEALRAESQSSRHQEEAAR 1960

Query: 729  ATSHTRS-----LNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQ 783
            A +          ++ +   E+      ELS  +EAS  T + +  L   Q     R L+
Sbjct: 1961 ARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAS--TATLQASLDACQAHS--RQLE 2016

Query: 784  ERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQR 843
            E L  Q+ +++++  R QE + +++  L ++   L  ++ R   EQ   +S+ + ++E  
Sbjct: 2017 EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQER---EQLLEKSLAQRVQENM 2073

Query: 844  KVTAQQMAMERAELE--------RAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKL 895
                Q +  ER E E        R     L +++  +L+  E ++R   E    S +   
Sbjct: 2074 IQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSP 2133

Query: 896  SKE----------RAEREAERALQVDTQREGTLISLAKEQAELKIRASELRA-----EEK 940
             +E          R +RE ER      Q E   I   ++  +L +  ++ +A     +E 
Sbjct: 2134 MEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEV 2193

Query: 941  QLAAERAALEQERQELRLEKERINATALRVKLRAEEVESM-SKVASEKYEEGERALREAQ 999
             +  + + LE++ ++ RL+ E      L +  RA E E + S  A+   E G R     Q
Sbjct: 2194 AMFLQASVLERDSEQQRLQDE------LELTRRALEKERLHSPGATSTAELGSRG---EQ 2244

Query: 1000 QVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRAR 1044
             VQ  + + ++A +   + + KQ      EHL  A  RL++DR+R
Sbjct: 2245 GVQLGEVSGVEA-EPSPDGMEKQSWRQRLEHLQQAVARLEIDRSR 2288



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 175/734 (23%), Positives = 303/734 (41%), Gaps = 126/734 (17%)

Query: 411  KLRAS---KEEKEDWLSHALSRKKSQ--GLAREQHAGTSEGLHLAGTAGHPPSGSQPLTS 465
            +LRAS   +E K   L   L   +SQ   LA EQ  G ++    A  A    +  Q L S
Sbjct: 1137 QLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPG-NQAQAQAQLASLYSALQQALGS 1195

Query: 466  TQGLEHAAAGGSSGTTARERPCVRPGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEP 525
                    +GG             P V G    QN A S       KRG     LSA   
Sbjct: 1196 VCESRPELSGGGDSA---------PSVWGLEPDQNGARSLF-----KRGPLLTALSAEAV 1241

Query: 526  ATCFPSTQKPTEPSVPVQPLLPESLAR--SLLPSTEYQK-----QLLAAQVQLQCSPAE- 577
            A+      +    +   + +L + + +    L  TE +K     +L   Q QL  +  E 
Sbjct: 1242 ASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK 1301

Query: 578  ---------LQAELLHSQARLAELEAQVRKLELER--AQHEL-LLGSLQQQHQADLELIE 625
                     L++EL+     +A L++++R+ EL+R  AQ E  LL + ++   A +E ++
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361

Query: 626  SA------HRSRIKVLETSYQQREERLRRENEELS-----ARYLSQCQEAEQARAELTAQ 674
            +A        S   +LE   +     L+ +NEE+      A+ L +  E + A+ +   +
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421

Query: 675  HQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLL------KDREVDAATS 728
            +   L     E+++E+E LR      I ++ +  E Q   L+LL      +++EVD    
Sbjct: 1422 NLALLTQTLAEREEEVETLR----GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQE 1477

Query: 729  ATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQ 788
                       I ++EK  S L  L   V        QERE  +  + EQ+R        
Sbjct: 1478 Q----------IQELEKCRSVLEHLPMAV--------QEREQKLTVQREQIR-------- 1511

Query: 789  QQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKA---ESMQRALEEQR-K 844
               ++E++R  Q+ V+      L ++ +++E +R +V   + +    E +   LEE   K
Sbjct: 1512 ---ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568

Query: 845  VTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEF----SAQQKLSKERA 900
            +  QQ  ++  E +R    +     ++ L+  E  + L A+ ++     S    L++E  
Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLE--ERSQELQAQSSQIHDLESHSTVLARELQ 1626

Query: 901  EREAERALQ------VDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQ 954
            ER+ E   Q      +  Q+E     L +   EL ++   ++  E Q   +   LE++ +
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686

Query: 955  ELRLE-KERINATALRVKL---RAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQ 1010
            +++L  +ER      + +L   RAEE +  SK      E  +  LR+ ++    QQ  + 
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746

Query: 1011 AVQQQQERLRKQEQHMH--------------QEHLSLAQQRLQLDRARQDL-PSSLVGLF 1055
             +Q+ +++L +Q Q +H              QE + L QQ+LQ  R + +L   SL    
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL-QQQLQEAREQGELKEQSLQSQL 1805

Query: 1056 PRAQGPAASSQSAL 1069
              AQ   A     L
Sbjct: 1806 DEAQRALAQRDQEL 1819



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 119/486 (24%), Positives = 208/486 (42%), Gaps = 77/486 (15%)

Query: 549  SLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLEL--ERAQH 606
            S A+ LL S+ ++ Q   + +++     E+Q + +     + + E +  KLEL  ER+Q 
Sbjct: 763  SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA 822

Query: 607  E-------LLLGSLQQQHQADLELIESAHRSRIKVL------ETSYQQRE-----ERLRR 648
            E         L   +Q+ +  LE  ++AH   +  L      E S+ Q+E     E L R
Sbjct: 823  EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLER 882

Query: 649  ENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDH 708
            E  EL  R   Q  E E  +A+   +  +  +A+ Q     M+   E +R S+L      
Sbjct: 883  EKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQ-----MQLETEKERVSLL------ 931

Query: 709  EEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQER 768
            E  LQ  K L D            ++ L  +   M+       E +  ++       +E 
Sbjct: 932  ETLLQTQKELADA-----------SQQLERLRQDMKVQKLKEQETTGILQTQLQEAQREL 980

Query: 769  ELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAE 828
            +   RQ  + L ALQE      +D  + + + +++  ++ A+ ++  RL+EQE       
Sbjct: 981  KEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQ-DDSQRLVEQE------- 1032

Query: 829  QSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAE 888
                  +Q  L E      Q+    + ELER K++L     S+M K   E+R L  + A+
Sbjct: 1033 ------VQEKLRE-----TQEYNRIQKELEREKASL---TLSLMEK---EQRLLVLQEAD 1075

Query: 889  FSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAA 948
               QQ+LS  R + +  +  Q +   +  L+     + E+K + ++  A+E QL  E  A
Sbjct: 1076 SIRQQELSALRQDMQEAQGEQKELSAQMELL-----RQEVKEKEADFLAQEAQLLEELEA 1130

Query: 949  LEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQAR 1008
                 Q+LR       A A +++LR    ES  +  + + + G +A     Q QA+  + 
Sbjct: 1131 SHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQA-----QAQAQLASL 1185

Query: 1009 LQAVQQ 1014
              A+QQ
Sbjct: 1186 YSALQQ 1191



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 129/568 (22%), Positives = 235/568 (41%), Gaps = 93/568 (16%)

Query: 553  SLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKL--ELERAQHELLL 610
            S +   E    +LA ++Q      E   E+   + ++ EL+ Q   L  +LER   EL+L
Sbjct: 1609 SQIHDLESHSTVLARELQ------ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAE 670
                   +  ++++E     + K+LE   +Q +  LR    EL+ +     + AE+ +  
Sbjct: 1663 ------QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716

Query: 671  LTAQHQ--RRLAAIAQEKDQEME----RLRELQRASILDMRRDHEEQLQRLKLLKDREVD 724
              AQ      +  I ++K++E+E     + ELQ     +++   E+QLQ L     R+V 
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ-----ELKDQLEQQLQGLH----RKVG 1767

Query: 725  AATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQE 784
              +   S       ++ Q  + +    EL  +   S L  +Q     + QRD++L ALQ+
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQR---ALAQRDQELEALQQ 1824

Query: 785  RLGQQQRDMEEERSRQQEVIGKMEARL-------------NEQSRLLEQERW----RVTA 827
               Q Q   E  + +   + G +E                 EQ+R LE+E      RV A
Sbjct: 1825 EQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQA 1884

Query: 828  EQSKAESMQRALEEQRK--VTAQQMAMERAELERAKSALLEEQ----KSVMLKCGEERRR 881
             +     ++    EQ K  +  QQ   E+A+    ++  L++     ++V+ +  +E   
Sbjct: 1885 LEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEA 1944

Query: 882  LAAEWAEFSAQQKLSKERAER------EAERALQVDTQR--EGTLISLAKEQAELKIRAS 933
            L AE      Q++ ++ RAE       +A  ALQ   Q   E   +S + E +   ++AS
Sbjct: 1945 LRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQAS 2004

Query: 934  -------------ELRAEEKQLAAE-----------RAALEQERQELRLEKERINATALR 969
                          LR +E ++  +           + AL Q  +ELR ++ER       
Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064

Query: 970  VKLRAEE--VESMSKVASEKYEEGERAL----REAQQVQAEQQARLQAVQQQQERLRKQE 1023
            +  R +E  ++    +  E+ EE  R L    RE Q   A+++  +  +++ Q+R   + 
Sbjct: 2065 LAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEA 2124

Query: 1024 QHMHQEHLSLAQQRLQLDRARQDLPSSL 1051
                 +   + +Q L+LD     L   L
Sbjct: 2125 LPHSHKTSPMEEQSLKLDSLEPRLQREL 2152



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 112/526 (21%), Positives = 236/526 (44%), Gaps = 28/526 (5%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQAR-----LAELEAQVRKLELERAQHELLLGSL 613
            E QK+L  ++ Q + +  +L  E LH +A+     LA    +   L  E+A  E+ L ++
Sbjct: 691  EIQKKLSESRHQQEAATTQL--EQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAV 748

Query: 614  QQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTA 673
            ++  Q   E ++    ++ ++LE+S  + +++     E    +   Q Q   QA+  +  
Sbjct: 749  ERDRQDLAEQLQGLSSAK-ELLESSLFEAQQQ-NSVIEVTKGQLEVQIQTVTQAKEVIQG 806

Query: 674  QHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHT 733
            + +     +  E+ Q  E+ R+     +    ++ +  L++ K   ++EV+         
Sbjct: 807  EVRCLKLELDTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE 865

Query: 734  RSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM 793
            RS +    ++ K   SL      +E        E E    QR+E+    +  L Q Q + 
Sbjct: 866  RSWHQ--QELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLET 923

Query: 794  EEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAME 853
            E+ER    E + + +  L + S+ LE+ R  +  ++ K +     L+ Q +   +++   
Sbjct: 924  EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEA 983

Query: 854  RAELERAKSALLEEQKSVMLKCGEERRR--------LAAEWAEFSAQQKLSKERAEREAE 905
              +     +AL EE  S++    + +++        +A + ++   +Q++ ++  E +  
Sbjct: 984  ARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEY 1043

Query: 906  RALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINA 965
              +Q + +RE   ++L+  + E ++    L+  +     E +AL Q+ QE + E++ ++A
Sbjct: 1044 NRIQKELEREKASLTLSLMEKEQRLLV--LQEADSIRQQELSALRQDMQEAQGEQKELSA 1101

Query: 966  --TALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQE 1023
                LR +++ +E + +++ A +  EE E +    QQ++A   A+     Q Q RLR  E
Sbjct: 1102 QMELLRQEVKEKEADFLAQEA-QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTE 1160

Query: 1024 QHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSAL 1069
              +  E L+  QQ     +A+  L +SL     +A G    S+  L
Sbjct: 1161 SQL--EALAAEQQPGNQAQAQAQL-ASLYSALQQALGSVCESRPEL 1203



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 128/563 (22%), Positives = 233/563 (41%), Gaps = 85/563 (15%)

Query: 561  QKQLLAAQVQLQCSPAELQ-AELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQA 619
            Q+QL+  + +    P++ Q   L H +  L + E +V   +    + + L   L+QQ Q 
Sbjct: 1702 QRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQG 1761

Query: 620  ------DLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTA 673
                  +  L+ S     I VL+   Q+  E+   + + L     SQ  EA++A     A
Sbjct: 1762 LHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ----SQLDEAQRA----LA 1813

Query: 674  QHQRRLAAIAQEKDQ---EMERLRE--------LQRASILDMRR-----DHEEQLQRLK- 716
            Q  + L A+ QE+ Q   + ER++E        L++A +    R     DH+EQ +RL+ 
Sbjct: 1814 QRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE 1873

Query: 717  --LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQ-------E 767
               ++ R V A        R+ +    + EK   +L +  +     H   ++       +
Sbjct: 1874 ELAVEGRRVQALEEVLGDLRAES---REQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930

Query: 768  RELGIRQRDEQLRALQERLGQQQRDMEEERSRQ---QEVIGKMEARLN----------EQ 814
             +  +++RD++L AL+      +   E  R+R    QE +GK  A L           E 
Sbjct: 1931 AQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAEL 1990

Query: 815  SRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAME----RAELERAKSALLEEQKS 870
            SR LE     + A     ++  R LEE  ++   ++  +    + ++++ + AL +  + 
Sbjct: 1991 SRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE 2050

Query: 871  VMLKCGEER---RRLAAEWAEFSAQQK--LSKERAEREAERALQVDTQREGTLISLAKEQ 925
            +  +   E+   + LA    E   Q+K  L +ER E E     Q  + RE  L    KEQ
Sbjct: 2051 LRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQ--SVRELQLTLAQKEQ 2108

Query: 926  AELKIRASELRAEEKQLAAERAALEQERQELRL---------EKERINATALRVKLRAEE 976
              L++R ++ R   + L         E Q L+L         E ER+ A   + + R  E
Sbjct: 2109 EILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIE 2168

Query: 977  VESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQ 1036
                ++  +    + + ++   Q+V    QA +     +Q+RL        Q+ L L ++
Sbjct: 2169 WREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL--------QDELELTRR 2220

Query: 1037 RLQLDRARQDLPSSLVGLFPRAQ 1059
             L+ +R      +S   L  R +
Sbjct: 2221 ALEKERLHSPGATSTAELGSRGE 2243



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 117/531 (22%), Positives = 215/531 (40%), Gaps = 91/531 (17%)

Query: 600  ELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLS 659
            ELE+  HE     +Q + Q DLE  E   R    V E S    + + + E+ E   + L 
Sbjct: 255  ELEKEAHERSQELIQLKSQGDLEKAELQDR----VTELSALLTQSQKQNEDYEKMIKALR 310

Query: 660  QCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRE------LQRASILDMRRDHEEQLQ 713
            +  E  +       +H+  L+  AQE+   ++++ +      ++    +     HE  L+
Sbjct: 311  ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE 370

Query: 714  R-LKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQ-----E 767
                +    +   A  A +  RS+  +  + +       +L+   EA +L   Q     E
Sbjct: 371  LDSSIFSQFDYQDADKALTLVRSV--LTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEE 428

Query: 768  RELGIRQRDEQLRALQERLGQQQRDMEEE---RSRQQEVIGKMEARLNEQSRLLEQERWR 824
                +RQR ++L   ++ L  Q  D++ E    S+++E++ K    L +Q  +LEQE WR
Sbjct: 429  EGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWR 488

Query: 825  VTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALL------EEQKSVMLKCGEE 878
            +     + +    + + Q++   +++ +   E ER +  L+       E  S ++   E 
Sbjct: 489  LRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREA 548

Query: 879  RRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAE 938
                  E  E   Q++     A   AE+++   +  E TL +   E A+L+  A +L A 
Sbjct: 549  LESSHLE-GELLRQEQTEVTAALARAEQSIAELSSSENTLKT---EVADLRAAAVKLSAL 604

Query: 939  EKQLAAERAALEQERQELRLEKERINA---------TALRVKLRAEEVESMSKVASEKYE 989
             + LA ++  L Q+  +L  E + + +          AL+V L   E E   +   EK  
Sbjct: 605  NEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLA--EAEKRREALWEKNT 662

Query: 990  EGERALREAQQVQAEQQARLQAVQQQQERLRK--------------QEQHMHQE------ 1029
              E  L++A++  AE QA L+ +Q+++E ++K              Q + +HQE      
Sbjct: 663  HLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEE 722

Query: 1030 -----------------------------HLSLAQQRLQLDRARQDLPSSL 1051
                                            LA+Q   L  A++ L SSL
Sbjct: 723  VLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL 773



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 117/518 (22%), Positives = 223/518 (43%), Gaps = 67/518 (12%)

Query: 543  QPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEA--QVRKLE 600
            Q L+ + +   L  + EY +     Q +L+   A L   L+  + RL  L+    +R+ E
Sbjct: 1026 QRLVEQEVQEKLRETQEYNR----IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081

Query: 601  LERAQHELLLGSLQQQH-QADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLS 659
            L   + ++     +Q+   A +EL+    R  +K  E  +  +E +L    EEL A +++
Sbjct: 1082 LSALRQDMQEAQGEQKELSAQMELL----RQEVKEKEADFLAQEAQLL---EELEASHIT 1134

Query: 660  Q--------CQEAEQARAELTAQH-QRRLAAIAQEKDQEMERLRELQRASILDMRRDHEE 710
            +         QEA+ A+ +L  +  + +L A+A E+    +   + Q AS+    +    
Sbjct: 1135 EQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALG 1194

Query: 711  QLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQEREL 770
             +   +       D+A S        N     + K    L  LS+   AS L    +   
Sbjct: 1195 SVCESRPELSGGGDSAPSVWGLEPDQNGA-RSLFKRGPLLTALSAEAVASALHKLHQDLW 1253

Query: 771  GIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQS 830
              +Q  + LR   ++L ++  D E E+S+       +   L +  R L Q +     E+S
Sbjct: 1254 KTQQTRDVLRDQVQKLEERLTDTEAEKSQ-------VHTELQDLQRQLSQNQ----EEKS 1302

Query: 831  KAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFS 890
            K E  Q +LE +     + MA  ++ L RA+   +E Q         ER  L A      
Sbjct: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG--------ERELLQA------ 1348

Query: 891  AQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALE 950
            A++ L+   A+ E  +A  V+ + + +   + +E       A +L+ EE +   ERA   
Sbjct: 1349 AKENLT---AQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL 1405

Query: 951  QERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQ 1010
            QE+ EL++ +          K   E +  +++  +E+ EE E    + Q+++ +++ +  
Sbjct: 1406 QEQGELKVAQG---------KALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKA 1456

Query: 1011 AVQQQQERLRKQEQHMHQEHLSLAQQRLQ-LDRARQDL 1047
            A++     L+K+ Q      + L Q+++Q L++ R  L
Sbjct: 1457 ALELLSLDLKKRNQ-----EVDLQQEQIQELEKCRSVL 1489



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 125/606 (20%), Positives = 241/606 (39%), Gaps = 124/606 (20%)

Query: 560  YQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQA 619
            +Q++L  A   L+    EL+  L   Q  +  ++AQ    E ER Q E  L  +Q + + 
Sbjct: 869  HQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQ---REEERTQAESALCQMQLETEK 925

Query: 620  D-LELIESAHRSRIKVLETSYQQREERLRRE-------NEELSARYLSQCQEAEQARAEL 671
            + + L+E+  +++ ++ + S  Q+ ERLR++        +E +    +Q QEA++   E 
Sbjct: 926  ERVSLLETLLQTQKELADAS--QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEA 983

Query: 672  TAQHQRRLAAIAQEK-------------------------------DQEM-ERLRELQRA 699
              QH+  LAA+ +E                                +QE+ E+LRE Q  
Sbjct: 984  ARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEY 1043

Query: 700  SILDMRRDHEEQLQRLKLL-KDREVDAATSATS-HTRSLNSIIHQMEKFSSSLHELSSRV 757
            + +    + E+    L L+ K++ +     A S   + L+++   M++      ELS+++
Sbjct: 1044 NRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM 1103

Query: 758  E-------------------------ASHLTTSQER-------------ELGIRQRDEQL 779
            E                         ASH+T  Q R             +L +R  + QL
Sbjct: 1104 ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQL 1163

Query: 780  RAL--QERLGQQ---QRDMEEERSRQQEVIGKMEARLNEQSRLLEQER--WRVTAEQSKA 832
             AL  +++ G Q   Q  +    S  Q+ +G +     E S   +     W +  +Q+ A
Sbjct: 1164 EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA 1223

Query: 833  ESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQ 892
             S+ +       ++A+ +A    +L +      + +  +  +  +   RL    AE S  
Sbjct: 1224 RSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV 1283

Query: 893  ----QKLSKERAEREAERALQVDTQR--EGTLISLAKEQAELKIRASELRAEEKQLAAER 946
                Q L ++ ++ + E++     Q   E  L+ L +  A L+ R      +  +   ER
Sbjct: 1284 HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGER 1343

Query: 947  AALEQERQELRLEKERINATALR---------------------VKLRAEEVESMSKVAS 985
              L+  ++ L  + E + A  +                      +KL+ EEVES  + A 
Sbjct: 1344 ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQ 1403

Query: 986  EKYEEGERALREAQQVQAEQQARLQAVQQQQERLRK-----QEQHMHQEHLSLAQQRLQL 1040
               E+GE  + + + +Q       Q + +++E +       QE    +E    A + L L
Sbjct: 1404 ALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSL 1463

Query: 1041 DRARQD 1046
            D  +++
Sbjct: 1464 DLKKRN 1469



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 131/573 (22%), Positives = 226/573 (39%), Gaps = 81/573 (14%)

Query: 542  VQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQA---ELLHSQARLAELEAQVRK 598
            +Q  L    A   L   E +++LL  Q        EL A   ++  +Q    EL AQ+  
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL 1105

Query: 599  LELERAQHELLLGSLQQQHQADLE---LIESAHRSRIKVLETSYQQREERLRRENEELSA 655
            L  E  + E    + + Q   +LE   + E   R+ +   E    Q + RLR    +L A
Sbjct: 1106 LRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEA 1165

Query: 656  RYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRA-----SILDMRRDHE- 709
                Q Q   QA+A+  AQ     +A+ Q      E   EL        S+  +  D   
Sbjct: 1166 LAAEQ-QPGNQAQAQ--AQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNG 1222

Query: 710  --EQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQE 767
                 +R  LL     +A  SA      L+  + + ++    L +   ++E     T  E
Sbjct: 1223 ARSLFKRGPLLTALSAEAVASAL---HKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAE 1279

Query: 768  RELGIRQRDEQLRALQERLGQQQRDMEE----ERSRQQEVIGKMEARLNEQSRLLEQERW 823
            +     Q   +L+ LQ +L Q Q +  +    + S + E++   E   + QSRL   E  
Sbjct: 1280 KS----QVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335

Query: 824  RVTAEQSKAESMQRALEEQRKVTAQ----QMAMERAELERAKSALLEEQ----------K 869
            R+ A Q + E +Q A E    +TAQ    Q A+  A  + + + +LEE           K
Sbjct: 1336 RMEA-QGERELLQAAKEN---LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLK 1391

Query: 870  SVMLKCGEERRRLAAEWAEFSAQQK---------LSKERAEREAE------RALQVDTQR 914
            +  ++   ER +   E  E    Q          L++  AERE E      +  +++ QR
Sbjct: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR 1451

Query: 915  EGTLISLAKEQAELKIRASELRAEEKQ---LAAERAALE------QERQ----------- 954
            E    +L     +LK R  E+  +++Q   L   R+ LE      QER+           
Sbjct: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIR 1511

Query: 955  ELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQ 1014
            EL  ++E          L  E+ + M +    + ++ ++ L   + +  E +     ++ 
Sbjct: 1512 ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMEC 1571

Query: 1015 QQERLRKQEQHMHQEHLSLAQQRLQLDRARQDL 1047
            QQ+ +++ E     + ++L    L L+   Q+L
Sbjct: 1572 QQKLIKELEGQRETQRVALTHLTLDLEERSQEL 1604



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 107/499 (21%), Positives = 189/499 (37%), Gaps = 100/499 (20%)

Query: 640  QQREERLRRENEELSARYLSQCQ--------------------------------EAEQA 667
            QQR+  L R+ +    +Y S CQ                                E EQ 
Sbjct: 49   QQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQ 108

Query: 668  RAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQR-LKLLKDREVDAA 726
            R E  A+   +L    ++ D   + LRE      +D  R  +E +++  +   ++E    
Sbjct: 109  RCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKG 168

Query: 727  TSATSHTRSLNSIIHQMEKFSSSLHELSS--------------RVEASHLTTSQERELGI 772
                 H R L S+  ++  F     E+ S              R+  S LT      +G 
Sbjct: 169  YLKGEHGRLL-SLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGA 227

Query: 773  RQRD---------EQLRALQERLGQQQRDMEEERSRQQEVI----------GKMEARLNE 813
            + R+          +   L   L + Q   +E   R QE+I           +++ R+ E
Sbjct: 228  QSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTE 287

Query: 814  QSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQK---- 869
             S LL Q +     +    E M +AL E  ++  +    E  E E + S   +E+K    
Sbjct: 288  LSALLTQSQ----KQNEDYEKMIKALRETVEI-LETNHTELMEHEASLSRNAQEEKLSLQ 342

Query: 870  -------SVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERAL----QVDTQREGTL 918
                    VM++ G+   + +           +  +   ++A++AL     V T+R   +
Sbjct: 343  QVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAV 402

Query: 919  ISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVE 978
              L ++ A  +   + L+ +  Q   E  AL Q  Q+L  E++ +    + ++    EV+
Sbjct: 403  QDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ---GEVD 459

Query: 979  SMSKVASEKYEEGERALREAQQVQAEQQARLQAVQ---QQQERLRKQEQHMHQEHLSLAQ 1035
            S+SK   E  ++    LR+  +V  ++  RL+ V    Q Q    + ++   QE L LA 
Sbjct: 460  SLSK-ERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAV 518

Query: 1036 QRLQLDRARQDLPSSLVGL 1054
                  R R+ L   L+GL
Sbjct: 519  ------RERERLQEMLMGL 531



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 100/419 (23%), Positives = 157/419 (37%), Gaps = 54/419 (12%)

Query: 649  ENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKD--QEMERLRELQRASILDMRR 706
            EN+  S R L   QEA+Q +A L  + Q   A + Q +   QE+E+  E     I     
Sbjct: 33   ENQAASWRKLKNSQEAQQRQATLVRKLQ---AKVLQYRSWCQELEKRLEATGGPIPQRWE 89

Query: 707  DHEE-QLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTS 765
            + EE  L  L +  + E     S       L   + + +  + +L E     +   LT  
Sbjct: 90   NVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALRE-----DVEKLTVD 144

Query: 766  QERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRV 825
                   R RDE +R       + Q  ME+E  +     G ++    E  RLL   R  V
Sbjct: 145  WS-----RARDELMRK------ESQWQMEQEFFK-----GYLK---GEHGRLLSLWREVV 185

Query: 826  TAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAE 885
            T  +   E       +  ++ A+ + +  + L       +  Q       G    R  A+
Sbjct: 186  TFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQ 245

Query: 886  WAEFSAQ-QKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAA 944
                 A+ Q+L KE  ER  E    +  + +G L     E+AEL+ R +EL A   Q   
Sbjct: 246  LLLLLAKTQELEKEAHERSQE---LIQLKSQGDL-----EKAELQDRVTELSALLTQSQK 297

Query: 945  ERAALEQERQELR--LEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQ 1002
            +    E+  + LR  +E    N T L      E   S+S+ A E+    ++ +++  QV 
Sbjct: 298  QNEDYEKMIKALRETVEILETNHTEL-----MEHEASLSRNAQEEKLSLQQVIKDITQVM 352

Query: 1003 AEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDR--------ARQDLPSSLVG 1053
             E+   +      +  L        Q     A + L L R        A QDL   L G
Sbjct: 353  VEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAG 411



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 72/331 (21%), Positives = 126/331 (38%), Gaps = 37/331 (11%)

Query: 546  LPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQ 605
            LP S   S  P  E   +L + + +LQ     LQA L  ++AR  E   + + L L  AQ
Sbjct: 2125 LPHSHKTS--PMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQ 2182

Query: 606  HELLLGSLQQ----QHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQC 661
             +  + SLQ+       + LE      R + ++  T     +ERL       +A   S+ 
Sbjct: 2183 TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRG 2242

Query: 662  QEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDR 721
            ++  Q   E++   +   +    EK    +RL  LQ+A            + RL++ + R
Sbjct: 2243 EQGVQL-GEVSGV-EAEPSPDGMEKQSWRQRLEHLQQA------------VARLEIDRSR 2288

Query: 722  EVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRA 781
                      H   L S + Q+E+    L   + R        +Q   L I +       
Sbjct: 2289 -------LQRHNVQLRSTLEQVERERRKLKREAMR-------AAQAGSLEISKATASSPT 2334

Query: 782  LQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEE 841
             Q+  GQ+  D +     Q+EV+  ++A+L  + +  +    R      +   +  +L  
Sbjct: 2335 QQDGRGQKNSDAKCVAELQKEVV-LLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSH 2393

Query: 842  QRKVTAQ--QMAMERAELERAKSALLEEQKS 870
                 AQ  +  +  AE  R   +L +   S
Sbjct: 2394 SLLAVAQAPEATVLEAETRRLDESLTQSLTS 2424



 Score = 32.3 bits (72), Expect = 2.6
 Identities = 44/177 (24%), Positives = 75/177 (42%), Gaps = 25/177 (14%)

Query: 831  KAESMQRALEEQRKVTAQQMA-MERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEF 889
            K +S+Q  LEEQ     QQMA  + A   + K++   +Q+   L      R+L A+  ++
Sbjct: 12   KPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLV-----RKLQAKVLQY 66

Query: 890  SAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAAL 949
             +  +  ++R E              G +    +   E  +    +R EE+Q   E  A 
Sbjct: 67   RSWCQELEKRLEATG-----------GPIPQRWENVEEPNLDELLVRLEEEQQRCESLAE 115

Query: 950  EQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQ 1006
               +  L +EK  +   ALR     E+VE ++   S   +E    +R+  Q Q EQ+
Sbjct: 116  VNTQLRLHMEKADVVNKALR-----EDVEKLTVDWSRARDE---LMRKESQWQMEQE 164


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
            [Homo sapiens]
          Length = 899

 Score =  101 bits (251), Expect = 5e-21
 Identities = 107/488 (21%), Positives = 228/488 (46%), Gaps = 40/488 (8%)

Query: 561  QKQLLAAQVQLQCSPAEL--QAELLHSQARLAELEAQVRKLELE-RAQHELLLGSLQQQH 617
            +K+L   + +L+    EL  Q EL   + ++ E E ++ + E + R Q E +    ++  
Sbjct: 320  EKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379

Query: 618  QADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQR 677
            + + ++ E   + R +  E    +++ERLR E EE         ++ E+ R E   Q Q 
Sbjct: 380  EQEKQMREQEQKMRDQ--EERMWEQDERLR-EKEERMREQEKMWEQVEKMREEKKMQEQE 436

Query: 678  RLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLN 737
            +     +EK QE ER+RE ++     MR + E   ++ + ++ +E               
Sbjct: 437  KKTRDQEEKMQEEERIREREKK----MREEEETMREQEEKMQKQE--------------E 478

Query: 738  SIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEER 797
            ++  Q EK          + +       QE+E  I +++E++R  +E  GQ+++   +E+
Sbjct: 479  NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 538

Query: 798  SRQQE-VIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAE 856
             R+QE  + + E ++ +Q + +  +  R+  E+   E  ++  +++ K+  ++   ER +
Sbjct: 539  MREQEDQMWEQEEKMRDQEQKMWDQEERM--EKKTQEQEKKTWDQEEKMREEERMREREK 596

Query: 857  LERAKSALLEEQKSVMLKCGEERRRLAAE-WAEFSAQQKLSKERAEREAERALQVDTQRE 915
              R +  ++ EQ+  M +  E+ +    + W +    Q+  ++  E+E +   Q +   E
Sbjct: 597  KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656

Query: 916  GTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAE 975
               +    EQ E      +++ +EK    E    EQE+ E + +++    T  + K+R E
Sbjct: 657  QQRLP---EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE-KKTWDQEKMREE 712

Query: 976  EVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQ----QQERLRKQEQHM-HQEH 1030
            E     +   +K  E E  +RE ++   EQ+ ++Q  ++    Q+E++ +QE+ M  Q+ 
Sbjct: 713  E---SMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR 769

Query: 1031 LSLAQQRL 1038
            L   +++L
Sbjct: 770  LPEQKEKL 777



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 100/477 (20%), Positives = 233/477 (48%), Gaps = 72/477 (15%)

Query: 570  QLQCSPAELQAELLHSQARLAELEAQVRKLE--LERAQH---ELLLGSLQQQHQADLELI 624
            +L+   AELQ +L  +++  +E++  V++L+  LERA+    ++   +LQ++     E +
Sbjct: 222  ELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEEL 281

Query: 625  ESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQ 684
                + +I+  E    ++EERLR +  ++        QE +  R E   + Q +     +
Sbjct: 282  REQEK-KIRKQEEKMWRQEERLREQEGKMRE------QEEKMWRQEKRLREQEK---ELR 331

Query: 685  EKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQME 744
            E+++E+   +EL         R+ EEQ+Q  +                      +  Q E
Sbjct: 332  EQEKELREQKEL---------REQEEQMQEQE--------------------EKMWEQEE 362

Query: 745  KFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM--EEERSRQQE 802
            K      ++  + E        E+E  +R++++++R  +ER+ +Q   +  +EER R+QE
Sbjct: 363  KMREQEEKMWRQEE-----RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 417

Query: 803  VIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAE--LERA 860
             + +   ++ E+ ++ EQE+ +   ++ K +  +R  E ++K+  ++  M   E  +++ 
Sbjct: 418  KMWEQVEKMREEKKMQEQEK-KTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 476

Query: 861  KSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLIS 920
            +  + E+++        +++RL  +  +   Q+K+ +E+ E+  E+  ++  Q E     
Sbjct: 477  EENMWEQEEKEW-----QQQRLPEQKEKLWEQEKM-QEQEEKIWEQEEKIRDQEE----- 525

Query: 921  LAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERI-NATALRVKLRAEEVES 979
                Q +   R  ++R +E Q+  +   +  + Q++  ++ER+   T  + K   ++ E 
Sbjct: 526  -MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK 584

Query: 980  MSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQ 1036
            M +   E+  E E+ +RE +++  EQ+ ++   Q+Q+E++++QE+ M ++   + +Q
Sbjct: 585  MRE--EERMREREKKMREEEEMMREQEEKM---QEQEEKMQEQEEKMWEQEEKMQEQ 636



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 86/474 (18%), Positives = 212/474 (44%), Gaps = 24/474 (5%)

Query: 579  QAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETS 638
            Q E +  + ++ E E + R  E E+ Q E  +   +++ + + E +        K  E  
Sbjct: 422  QVEKMREEKKMQEQEKKTRDQE-EKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 480

Query: 639  YQQRE-----ERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERL 693
            ++Q E     +RL  + E+L  +   Q QE +    E   + Q  +    ++K    E++
Sbjct: 481  WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG-QEKKMWRQEKM 539

Query: 694  RELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHEL 753
            RE Q   + +      +Q Q++   ++R           T      + + E+      ++
Sbjct: 540  RE-QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKM 598

Query: 754  SSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSR---QQEVIGKMEAR 810
                E       +E+E  +++++E+++  +E++ +Q+  M+E+  +   Q+E + + E +
Sbjct: 599  REEEEMM-----REQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653

Query: 811  LNEQSRLLEQER--WR--VTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLE 866
            + EQ RL EQ+   W      EQ K +  +  + EQ K+  +    E+   ++ K    E
Sbjct: 654  MWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEE 713

Query: 867  EQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQA 926
              +    K  EE   +  +  +   Q++  +E+ E   E+  ++  Q E         + 
Sbjct: 714  SMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQ 773

Query: 927  ELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEV----ESMSK 982
            + K+   E   E++++  +   +  + +++R ++E++     +++ + E++    E M  
Sbjct: 774  KEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWG 833

Query: 983  VASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQ 1036
               + + + E+   + ++++ + Q + + +++Q+E++R QE+ M ++   +  Q
Sbjct: 834  QEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 95/476 (19%), Positives = 211/476 (44%), Gaps = 39/476 (8%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGS--LQQQ 616
            E +KQ+   + +++    + +  +     RL E E ++R+ E    Q E +     +Q+Q
Sbjct: 380  EQEKQMREQEQKMR----DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435

Query: 617  HQADLELIESAHRS-RIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQH 675
             +   +  E      RI+  E   ++ EE +R + E++  +  +  ++ E+   +     
Sbjct: 436  EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 495

Query: 676  QRRLAAIAQEKDQEMERLRELQRASILDMRR--DHEEQLQRLKLLKDREVDAATSATSHT 733
            Q+      QEK QE E     Q   I D       E+++ R + ++++E           
Sbjct: 496  QKE-KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR 554

Query: 734  RSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM 793
                 +  Q E+      E   +         +E  +  R+R++++R  +E + +Q+  M
Sbjct: 555  DQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERM--REREKKMREEEEMMREQEEKM 612

Query: 794  ---EEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQM 850
               EE+   Q+E + + E ++ EQ   + ++  ++  ++ K    QR  E++ K+   + 
Sbjct: 613  QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 672

Query: 851  AMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQV 910
              E+ +++  +  + E++K  M K  +E+ +   +      Q+K+ +E + RE E+ ++ 
Sbjct: 673  MQEQEKMQEQEEKIWEQEK--MEKKTQEQEKKTWD------QEKMREEESMREREKKMRE 724

Query: 911  DTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRV 970
            + +       + +EQ E      E   E+++   E+     E++E   E++R+       
Sbjct: 725  EEE-------MMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLP----EQ 773

Query: 971  KLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHM 1026
            K +  E E M +   EK  E E  +R+ ++    Q+ +++    Q+E++R QE+ M
Sbjct: 774  KEKLWEHEKMQE--QEKIWEQEEKMRDQEEKMRGQEEKMRG---QEEKMRGQEEKM 824



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 102/483 (21%), Positives = 210/483 (43%), Gaps = 92/483 (19%)

Query: 577  ELQAELLHSQARLAELEAQ---VRKLELERAQHELLL------------GSLQQQHQADL 621
            E +A   H +A   E+EAQ   +R L  ++ + E  L            G+L      +L
Sbjct: 82   EKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNL 141

Query: 622  ELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAA 681
             L ++   S +  + TS       +  E+++L+ R       A + +  L+A   R   A
Sbjct: 142  ALSQAFRGSPLGCVSTSL------IPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKA 195

Query: 682  IAQEKDQEMERLRELQRASILDMRRDH--EEQLQRLKLLKDREVDAATSATSHTRSLNSI 739
                 D+ +E L + + A  L++ R+    E+L++       ++  A S  S        
Sbjct: 196  -----DRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKS-------- 242

Query: 740  IHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSR 799
                 +   ++ EL  ++E +     Q           Q   LQE + +Q+ ++ E+  +
Sbjct: 243  -----EIQLNVKELKRKLERAKFLLPQV----------QTNTLQEEMWRQEEELREQEKK 287

Query: 800  ---QQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAE 856
               Q+E + + E RL EQ   + ++  ++  ++ +    ++ L EQ K   +Q  +   E
Sbjct: 288  IRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQE 347

Query: 857  LERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREG 916
             +      ++EQ+  M +  EE+ R   E      ++   +E+  RE E+ ++   +R  
Sbjct: 348  EQ------MQEQEEKMWE-QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER-- 398

Query: 917  TLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEE 976
                + ++   L+ +   +R +EK        + ++ +++R EK            + +E
Sbjct: 399  ----MWEQDERLREKEERMREQEK--------MWEQVEKMREEK------------KMQE 434

Query: 977  VESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHM-HQEHLSLAQ 1035
             E  ++   EK +E ER +RE ++   E++   + +++Q+E+++KQE++M  QE     Q
Sbjct: 435  QEKKTRDQEEKMQEEER-IREREKKMREEE---ETMREQEEKMQKQEENMWEQEEKEWQQ 490

Query: 1036 QRL 1038
            QRL
Sbjct: 491  QRL 493



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 75/331 (22%), Positives = 140/331 (42%), Gaps = 25/331 (7%)

Query: 561 QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLE-LERAQHELLLGS---LQQQ 616
           Q++ +  + Q Q      Q E +  + R+ E E ++R+ E + R Q E +      +Q+Q
Sbjct: 563 QEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 622

Query: 617 HQADLELIESAHRSRIKVLETS---YQQRE-----ERLRRENEELSARYLSQCQEAEQAR 668
            +   E  E       K+ E     ++Q E     +RL  + E+L      Q QE  Q +
Sbjct: 623 EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ 682

Query: 669 AE-LTAQHQRRLAAIAQEK---DQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVD 724
            E +  Q +       QEK   DQE  R  E  R     MR + E   ++ + ++++E  
Sbjct: 683 EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEK 742

Query: 725 AATSATSHTRSLNSIIHQMEKF--SSSLHELSSRVEASHLTTSQERELGIRQRDEQLRAL 782
                         +  Q EK      L E   ++        QE+   I +++E++R  
Sbjct: 743 MQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK---IWEQEEKMRDQ 799

Query: 783 QERL-GQQQ--RDMEEE-RSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRA 838
           +E++ GQ++  R  EE+ R +++++ G+ E    ++ ++  QE      E+   E MQ  
Sbjct: 800 EEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQ 859

Query: 839 LEEQRKVTAQQMAMERAELERAKSALLEEQK 869
            E+ R+   +    E    E+ +    +E+K
Sbjct: 860 EEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890


>gi|62243374 MAD1-like 1 protein [Homo sapiens]
          Length = 718

 Score =  100 bits (248), Expect = 1e-20
 Identities = 144/630 (22%), Positives = 264/630 (41%), Gaps = 100/630 (15%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELE----AQVRKLELERAQHELLLGSLQ 614
            E  +Q+ +    +Q    ++Q EL H +AR+ ELE       R  E E  +++ LL  ++
Sbjct: 53   ERAEQIRSKSHLIQVEREKMQMELSHKRARV-ELERAASTSARNYEREVDRNQELLTRIR 111

Query: 615  QQHQ----ADLELIESAHRSR-----IKVLETSYQQREERLRRENEELSA--------RY 657
            Q  +    A+ ++ E   R+R     +       +++E+ L +  E ++A        ++
Sbjct: 112  QLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQW 171

Query: 658  LSQCQEAEQARAELTAQHQRRLAAIAQEKDQEM-ERLRELQRASILDMRRDHEEQLQRLK 716
                QE    R E   Q  +    +  +K QE  ++++ELQ +   + R DHE+Q++ L+
Sbjct: 172  SVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ--EARADHEQQIKDLE 229

Query: 717  L-LKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR 775
              L  +E DAA       +++ S + ++ +    L +L  R E++HL   +E   G+ Q 
Sbjct: 230  QKLSLQEQDAAI-----VKNMKSELVRLPRLERELKQL--REESAHLREMRETN-GLLQ- 280

Query: 776  DEQLRALQERLGQQQR--------DMEEERS------------------RQQEVIGKMEA 809
             E+L  LQ +LG+Q++        ++E ER                   R  E + +   
Sbjct: 281  -EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVV 339

Query: 810  RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQK 869
             L ++   L+ +   VT+     E  ++ L+E+ +  + Q+  ER + E  ++     QK
Sbjct: 340  ELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQK 399

Query: 870  SVMLKCGEE--RRRLAAEW------AEFSAQQKLSKERAEREAERALQVDTQREGTLISL 921
             V+L   E    R +   +      AE+S Q       AE   ++      + E  L   
Sbjct: 400  RVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQA 459

Query: 922  AKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMS 981
             +E    K RA  L  E K L ++ ++ EQ     R E + +       +L+ EE+E   
Sbjct: 460  LEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL-------RLKVEELE--- 509

Query: 982  KVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLD 1041
                     GER+  E ++   E Q   +A+Q   ++ R +  HM     S+A+QRL+ D
Sbjct: 510  ---------GERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED 560

Query: 1042 RARQDLPSSLVGLFPRAQGPAASSQSALMPPAPTTRWCSQPPTGLDPSPLHLHARLALLR 1101
                   S L     R +G   + +     PA      +  P+  + + L      A L+
Sbjct: 561  H------SQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELK 614

Query: 1102 HMAEQDRDFLENEQFFLETLKKGSYNLTSH 1131
                 ++   E  Q  ++  +K  Y LT +
Sbjct: 615  -----NQRLKEVFQTKIQEFRKACYTLTGY 639



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 99/456 (21%), Positives = 208/456 (45%), Gaps = 50/456 (10%)

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAE 670
            GSLQ Q+Q  ++L E A + R K      Q   E+++ E     AR      E E+A + 
Sbjct: 39   GSLQMQYQQSMQLEERAEQIRSK--SHLIQVEREKMQMELSHKRARV-----ELERAAST 91

Query: 671  LTAQHQRRLAAIAQEKDQEM-ERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSA 729
                ++R +     +++QE+  R+R+LQ           +EQL+R +  + + +DAA+  
Sbjct: 92   SARNYEREV-----DRNQELLTRIRQLQEREA-GAEEKMQEQLERNRQCQ-QNLDAAS-- 142

Query: 730  TSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQ 789
                + L      + +   +++ L  R+     +   ++E+ +++ + + + LQE+L  Q
Sbjct: 143  ----KRLREKEDSLAQAGETINALKGRISELQWSV-MDQEMRVKRLESEKQELQEQLDLQ 197

Query: 790  QRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKA--ESMQR------ALEE 841
             +  +E   + QE+    EAR + + ++ + E+     EQ  A  ++M+        LE 
Sbjct: 198  HKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLER 257

Query: 842  QRKVTAQQMAMERAELERAKSALLEEQKSVMLKCG-EERRRLAAEWAEFSAQQKLSKERA 900
            + K   ++ A  R E+      L EE + +  K G +E+ +      E   ++ L+K ++
Sbjct: 258  ELKQLREESAHLR-EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS 316

Query: 901  EREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEK 960
                ++ + +  +   T   L++   EL+ R   L+ +   + +    LE+ RQ+L+ E 
Sbjct: 317  WERLDQTMGLSIR---TPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEEL 373

Query: 961  ERINATALRVKLRAEEVESMSK------VASEKYEEGERAL---REAQQVQAEQQARLQA 1011
             +++   L  + + E  E++++      +   K  +G RA+    +++   AE   +L  
Sbjct: 374  RQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQL-- 431

Query: 1012 VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDL 1047
                  R+R+ E  + + H   A+   QL +A ++L
Sbjct: 432  ----TRRMREAEDMVQKVHSHSAEMEAQLSQALEEL 463


>gi|62243369 MAD1-like 1 protein [Homo sapiens]
          Length = 718

 Score =  100 bits (248), Expect = 1e-20
 Identities = 144/630 (22%), Positives = 264/630 (41%), Gaps = 100/630 (15%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELE----AQVRKLELERAQHELLLGSLQ 614
            E  +Q+ +    +Q    ++Q EL H +AR+ ELE       R  E E  +++ LL  ++
Sbjct: 53   ERAEQIRSKSHLIQVEREKMQMELSHKRARV-ELERAASTSARNYEREVDRNQELLTRIR 111

Query: 615  QQHQ----ADLELIESAHRSR-----IKVLETSYQQREERLRRENEELSA--------RY 657
            Q  +    A+ ++ E   R+R     +       +++E+ L +  E ++A        ++
Sbjct: 112  QLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQW 171

Query: 658  LSQCQEAEQARAELTAQHQRRLAAIAQEKDQEM-ERLRELQRASILDMRRDHEEQLQRLK 716
                QE    R E   Q  +    +  +K QE  ++++ELQ +   + R DHE+Q++ L+
Sbjct: 172  SVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ--EARADHEQQIKDLE 229

Query: 717  L-LKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR 775
              L  +E DAA       +++ S + ++ +    L +L  R E++HL   +E   G+ Q 
Sbjct: 230  QKLSLQEQDAAI-----VKNMKSELVRLPRLERELKQL--REESAHLREMRETN-GLLQ- 280

Query: 776  DEQLRALQERLGQQQR--------DMEEERS------------------RQQEVIGKMEA 809
             E+L  LQ +LG+Q++        ++E ER                   R  E + +   
Sbjct: 281  -EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVV 339

Query: 810  RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQK 869
             L ++   L+ +   VT+     E  ++ L+E+ +  + Q+  ER + E  ++     QK
Sbjct: 340  ELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQK 399

Query: 870  SVMLKCGEE--RRRLAAEW------AEFSAQQKLSKERAEREAERALQVDTQREGTLISL 921
             V+L   E    R +   +      AE+S Q       AE   ++      + E  L   
Sbjct: 400  RVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQA 459

Query: 922  AKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMS 981
             +E    K RA  L  E K L ++ ++ EQ     R E + +       +L+ EE+E   
Sbjct: 460  LEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL-------RLKVEELE--- 509

Query: 982  KVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLD 1041
                     GER+  E ++   E Q   +A+Q   ++ R +  HM     S+A+QRL+ D
Sbjct: 510  ---------GERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED 560

Query: 1042 RARQDLPSSLVGLFPRAQGPAASSQSALMPPAPTTRWCSQPPTGLDPSPLHLHARLALLR 1101
                   S L     R +G   + +     PA      +  P+  + + L      A L+
Sbjct: 561  H------SQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELK 614

Query: 1102 HMAEQDRDFLENEQFFLETLKKGSYNLTSH 1131
                 ++   E  Q  ++  +K  Y LT +
Sbjct: 615  -----NQRLKEVFQTKIQEFRKACYTLTGY 639



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 99/456 (21%), Positives = 208/456 (45%), Gaps = 50/456 (10%)

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAE 670
            GSLQ Q+Q  ++L E A + R K      Q   E+++ E     AR      E E+A + 
Sbjct: 39   GSLQMQYQQSMQLEERAEQIRSK--SHLIQVEREKMQMELSHKRARV-----ELERAAST 91

Query: 671  LTAQHQRRLAAIAQEKDQEM-ERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSA 729
                ++R +     +++QE+  R+R+LQ           +EQL+R +  + + +DAA+  
Sbjct: 92   SARNYEREV-----DRNQELLTRIRQLQEREA-GAEEKMQEQLERNRQCQ-QNLDAAS-- 142

Query: 730  TSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQ 789
                + L      + +   +++ L  R+     +   ++E+ +++ + + + LQE+L  Q
Sbjct: 143  ----KRLREKEDSLAQAGETINALKGRISELQWSV-MDQEMRVKRLESEKQELQEQLDLQ 197

Query: 790  QRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKA--ESMQR------ALEE 841
             +  +E   + QE+    EAR + + ++ + E+     EQ  A  ++M+        LE 
Sbjct: 198  HKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLER 257

Query: 842  QRKVTAQQMAMERAELERAKSALLEEQKSVMLKCG-EERRRLAAEWAEFSAQQKLSKERA 900
            + K   ++ A  R E+      L EE + +  K G +E+ +      E   ++ L+K ++
Sbjct: 258  ELKQLREESAHLR-EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS 316

Query: 901  EREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEK 960
                ++ + +  +   T   L++   EL+ R   L+ +   + +    LE+ RQ+L+ E 
Sbjct: 317  WERLDQTMGLSIR---TPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEEL 373

Query: 961  ERINATALRVKLRAEEVESMSK------VASEKYEEGERAL---REAQQVQAEQQARLQA 1011
             +++   L  + + E  E++++      +   K  +G RA+    +++   AE   +L  
Sbjct: 374  RQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQL-- 431

Query: 1012 VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDL 1047
                  R+R+ E  + + H   A+   QL +A ++L
Sbjct: 432  ----TRRMREAEDMVQKVHSHSAEMEAQLSQALEEL 463


>gi|62243332 MAD1-like 1 protein [Homo sapiens]
          Length = 718

 Score =  100 bits (248), Expect = 1e-20
 Identities = 144/630 (22%), Positives = 264/630 (41%), Gaps = 100/630 (15%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELE----AQVRKLELERAQHELLLGSLQ 614
            E  +Q+ +    +Q    ++Q EL H +AR+ ELE       R  E E  +++ LL  ++
Sbjct: 53   ERAEQIRSKSHLIQVEREKMQMELSHKRARV-ELERAASTSARNYEREVDRNQELLTRIR 111

Query: 615  QQHQ----ADLELIESAHRSR-----IKVLETSYQQREERLRRENEELSA--------RY 657
            Q  +    A+ ++ E   R+R     +       +++E+ L +  E ++A        ++
Sbjct: 112  QLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQW 171

Query: 658  LSQCQEAEQARAELTAQHQRRLAAIAQEKDQEM-ERLRELQRASILDMRRDHEEQLQRLK 716
                QE    R E   Q  +    +  +K QE  ++++ELQ +   + R DHE+Q++ L+
Sbjct: 172  SVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ--EARADHEQQIKDLE 229

Query: 717  L-LKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR 775
              L  +E DAA       +++ S + ++ +    L +L  R E++HL   +E   G+ Q 
Sbjct: 230  QKLSLQEQDAAI-----VKNMKSELVRLPRLERELKQL--REESAHLREMRETN-GLLQ- 280

Query: 776  DEQLRALQERLGQQQR--------DMEEERS------------------RQQEVIGKMEA 809
             E+L  LQ +LG+Q++        ++E ER                   R  E + +   
Sbjct: 281  -EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVV 339

Query: 810  RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQK 869
             L ++   L+ +   VT+     E  ++ L+E+ +  + Q+  ER + E  ++     QK
Sbjct: 340  ELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQK 399

Query: 870  SVMLKCGEE--RRRLAAEW------AEFSAQQKLSKERAEREAERALQVDTQREGTLISL 921
             V+L   E    R +   +      AE+S Q       AE   ++      + E  L   
Sbjct: 400  RVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQA 459

Query: 922  AKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMS 981
             +E    K RA  L  E K L ++ ++ EQ     R E + +       +L+ EE+E   
Sbjct: 460  LEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL-------RLKVEELE--- 509

Query: 982  KVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLD 1041
                     GER+  E ++   E Q   +A+Q   ++ R +  HM     S+A+QRL+ D
Sbjct: 510  ---------GERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED 560

Query: 1042 RARQDLPSSLVGLFPRAQGPAASSQSALMPPAPTTRWCSQPPTGLDPSPLHLHARLALLR 1101
                   S L     R +G   + +     PA      +  P+  + + L      A L+
Sbjct: 561  H------SQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELK 614

Query: 1102 HMAEQDRDFLENEQFFLETLKKGSYNLTSH 1131
                 ++   E  Q  ++  +K  Y LT +
Sbjct: 615  -----NQRLKEVFQTKIQEFRKACYTLTGY 639



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 99/456 (21%), Positives = 208/456 (45%), Gaps = 50/456 (10%)

Query: 611  GSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAE 670
            GSLQ Q+Q  ++L E A + R K      Q   E+++ E     AR      E E+A + 
Sbjct: 39   GSLQMQYQQSMQLEERAEQIRSK--SHLIQVEREKMQMELSHKRARV-----ELERAAST 91

Query: 671  LTAQHQRRLAAIAQEKDQEM-ERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSA 729
                ++R +     +++QE+  R+R+LQ           +EQL+R +  + + +DAA+  
Sbjct: 92   SARNYEREV-----DRNQELLTRIRQLQEREA-GAEEKMQEQLERNRQCQ-QNLDAAS-- 142

Query: 730  TSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQ 789
                + L      + +   +++ L  R+     +   ++E+ +++ + + + LQE+L  Q
Sbjct: 143  ----KRLREKEDSLAQAGETINALKGRISELQWSV-MDQEMRVKRLESEKQELQEQLDLQ 197

Query: 790  QRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKA--ESMQR------ALEE 841
             +  +E   + QE+    EAR + + ++ + E+     EQ  A  ++M+        LE 
Sbjct: 198  HKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLER 257

Query: 842  QRKVTAQQMAMERAELERAKSALLEEQKSVMLKCG-EERRRLAAEWAEFSAQQKLSKERA 900
            + K   ++ A  R E+      L EE + +  K G +E+ +      E   ++ L+K ++
Sbjct: 258  ELKQLREESAHLR-EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS 316

Query: 901  EREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEK 960
                ++ + +  +   T   L++   EL+ R   L+ +   + +    LE+ RQ+L+ E 
Sbjct: 317  WERLDQTMGLSIR---TPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEEL 373

Query: 961  ERINATALRVKLRAEEVESMSK------VASEKYEEGERAL---REAQQVQAEQQARLQA 1011
             +++   L  + + E  E++++      +   K  +G RA+    +++   AE   +L  
Sbjct: 374  RQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQL-- 431

Query: 1012 VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDL 1047
                  R+R+ E  + + H   A+   QL +A ++L
Sbjct: 432  ----TRRMREAEDMVQKVHSHSAEMEAQLSQALEEL 463


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 101/467 (21%), Positives = 220/467 (47%), Gaps = 44/467 (9%)

Query: 585  SQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREE 644
            ++ R+  L+ +  KL+    + E  +  LQ+Q + DL+  E+  +  +K  E   +Q EE
Sbjct: 820  TEMRVKLLQEENEKLQGRSEELERRVAQLQRQIE-DLKGDEAKAKETLKKYEGEIRQLEE 878

Query: 645  RL----RRENEELSARYLSQCQ-EAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRA 699
             L    + E E +SAR   + + EA Q     T Q Q++L+   +E+ ++ E+LR L+  
Sbjct: 879  ALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKN- 937

Query: 700  SILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSL-NSIIHQMEKFSSSLHELSSRVE 758
               +M  +     + ++ L+    D   ++ + T  L N +    EK    L E+  +++
Sbjct: 938  ---EMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLK 994

Query: 759  ASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQ---EVIGKMEARLNEQS 815
               L   + R   ++ +DE +R ++E L   QR  +E  +++Q   + +  +E  L  +S
Sbjct: 995  EKTLEAEKSRLTAMKMQDE-MRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS 1053

Query: 816  RLLEQERWRVTAEQSKAESMQRALEEQRK---VTAQQMAMERAELERAKSALLEEQKSVM 872
             L +     V   + K   ++  LEE+R    + +++++  R ++E+ ++ LL+E+ +  
Sbjct: 1054 HLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQ 1113

Query: 873  -LKCGEERRRLAAEWAEFSAQQKLSKERAEREAE-RALQVD----TQREGTLISLAKEQA 926
             L+C                  K+S ER  ++ + R + ++    + +EG ++ +    A
Sbjct: 1114 DLEC-----------------DKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIA 1156

Query: 927  ELKIRASELRAEEKQLAAERAALEQERQEL--RLEKERINATALRVKLRAEEVESMSKVA 984
            EL+ R      +   L      LE++ +EL  +++ E ++ T  + +L +  +++M +  
Sbjct: 1157 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQL-SLRLKAMKRQV 1215

Query: 985  SEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHL 1031
             E  EE +R     +++Q E + ++   +  Q +L   ++ +  + L
Sbjct: 1216 EEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKL 1262



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 119/537 (22%), Positives = 229/537 (42%), Gaps = 55/537 (10%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRK-------LELERAQHELLLG 611
            E ++++ A   +L+    E   E    Q RL E E ++RK       +++ER QH+  + 
Sbjct: 642  EERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIR 701

Query: 612  SLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAEL 671
             LQ Q     + ++SA RS         + RE+    E    + + L     A++ + +L
Sbjct: 702  DLQDQLSEMHDELDSAKRS---------EDREKGALIEELLQAKQDLQDLLIAKEEQEDL 752

Query: 672  TAQHQRRLAAI-------AQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVD 724
              + +R L A+           DQEM++L+E   A +  +R   EE  + +++L  R   
Sbjct: 753  LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNT 812

Query: 725  AATSATSHTRSLNSIIHQMEKFSSSLHELSSRV-----EASHLTTSQER-ELGIRQRDEQ 778
            +          +  +  + EK      EL  RV     +   L   + + +  +++ + +
Sbjct: 813  SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872

Query: 779  LRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRA 838
            +R L+E L   +++ +E  S ++ +  ++EA     S+  +++  +  +E+ K ES Q+ 
Sbjct: 873  IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQ--KQLSEKLKEESEQK- 929

Query: 839  LEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKE 898
              EQ +    +M  ER  L +    L +E   ++    E  R    E      + K    
Sbjct: 930  --EQLRRLKNEMENERWHLGKTIEKLQKEMADIV----EASRTSTLELQNQLDEYKEKNR 983

Query: 899  RAEREAERALQVDT-QREGTLISLAKEQAELKIRASELRAEEK---QLAAERAALEQERQ 954
            R   E +R L+  T + E + ++  K Q E+++   ELR  ++   +   +R  LEQ  +
Sbjct: 984  RELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLK 1043

Query: 955  ELRLEKERINATALRVKLRAEEVES-MSKVASEKYEEGERALREAQQVQAEQQARLQAVQ 1013
            +L  E        L  K   ++  S + K   +K  + E  L E +        R+   +
Sbjct: 1044 DLEYE--------LEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR 1095

Query: 1014 QQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSALM 1070
            +Q E+LR +          L   ++ L+R  +DL S ++ L    +G   SS+  L+
Sbjct: 1096 EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHL----EGSYRSSKEGLV 1148



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 105/390 (26%), Positives = 176/390 (45%), Gaps = 57/390 (14%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            + +L AAQ  L  +  E Q +L       +E + Q+R+L+ E       LG   ++ Q +
Sbjct: 898  ENELEAAQGNLSQTTQE-QKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKE 956

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLA 680
            +  I  A R+    L+    + +E+ RRE  E+  +   +  EAE++R  LTA       
Sbjct: 957  MADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSR--LTAM------ 1008

Query: 681  AIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKD--REVDAATSATSHTRSLNS 738
                 K Q+  RL E     + D +R  +E L + +LL+   ++++    A SH +   S
Sbjct: 1009 -----KMQDEMRLME---EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS 1060

Query: 739  -IIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLR--ALQER---------- 785
             ++ QME   S L E+    E ++     ER    R++ EQLR   LQER          
Sbjct: 1061 RLVKQMEDKVSQL-EMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDK 1119

Query: 786  --LGQQQRDMEEE--------RSRQQEVIGKMEARLNE-QSRLLEQERWRVTAEQSKAES 834
              L +Q +D++          RS ++ ++ +MEAR+ E + RL  +ER R   + S    
Sbjct: 1120 ISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLS---- 1175

Query: 835  MQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQK 894
              R LE + K    Q+  E   L   K     +Q S+ LK     +R   E  E   + +
Sbjct: 1176 -NRRLERKVKELVMQVDDEHLSLTDQK-----DQLSLRLKA---MKRQVEEAEEEIDRLE 1226

Query: 895  LSKERAEREAERALQVDTQREGTLISLAKE 924
             SK++ +RE E  + ++   +G L S+ K+
Sbjct: 1227 SSKKKLQRELEEQMDMNEHLQGQLNSMKKD 1256



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 82/390 (21%), Positives = 172/390 (44%), Gaps = 43/390 (11%)

Query: 659  SQCQEAEQARAELT---AQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRL 715
            S+ ++  + +++LT   A+ QR+L  +  +  Q ++  RE  RA++ ++R  H E+++  
Sbjct: 607  SEVKDLLEQKSKLTIEVAELQRQLQ-LEVKNQQNIKEERERMRANLEELRSQHNEKVEEN 665

Query: 716  KLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQR 775
              L+ R  ++      +   L  +  + E+  + + +L  ++   H     E +   R  
Sbjct: 666  STLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMH----DELDSAKRSE 721

Query: 776  DEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESM 835
            D +  AL E L Q ++D+      Q  +I K      EQ  LL +    +TA       +
Sbjct: 722  DREKGALIEELLQAKQDL------QDLLIAK-----EEQEDLLRKRERELTA-------L 763

Query: 836  QRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKL 895
            + AL+E+  V++    M++          L+EQ    L+   E    A +  E  A +  
Sbjct: 764  KGALKEE--VSSHDQEMDK----------LKEQYDAELQALRESVEEATKNVEVLASRSN 811

Query: 896  SKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQE 955
            + E+ +   E  +++  Q E   +    E  EL+ R ++L+ + + L  + A  ++  ++
Sbjct: 812  TSEQDQAGTEMRVKL-LQEENEKLQGRSE--ELERRVAQLQRQIEDLKGDEAKAKETLKK 868

Query: 956  LRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQ 1015
               E  ++    +  +   +E  S  +    + E  +  L +  Q Q +   +L+   +Q
Sbjct: 869  YEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ 928

Query: 1016 QERLRKQEQHMHQE--HLSLAQQRLQLDRA 1043
            +E+LR+ +  M  E  HL    ++LQ + A
Sbjct: 929  KEQLRRLKNEMENERWHLGKTIEKLQKEMA 958


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 123/512 (24%), Positives = 231/512 (45%), Gaps = 59/512 (11%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            ++  + + V L+ S AE Q E+L        LE Q+  L LE +Q       LQ Q    
Sbjct: 386  RRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQ---- 441

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSA------RYLSQCQEAEQARAELTAQ 674
            L  + +  +++++   +S QQR++ L  E + L        R ++  Q   +A+    A 
Sbjct: 442  LAALSTKLQAQVECSHSS-QQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLAS 500

Query: 675  HQRRLAAIAQEKDQEMERLRELQRA------SILDMRRDH---EEQLQRLKLLKDREVDA 725
                L    ++  + M ++ ++QR+      ++ D+R+     + QLQ+++L +      
Sbjct: 501  SNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSK 560

Query: 726  ATSATSHTRSLNSIIHQMEKFSSSLHELSSRV--EASHLTTSQERELGIRQRDEQLRALQ 783
              ++ +   SL S+    ++  +   E   R+  E +H+   Q  + G+    E L+   
Sbjct: 561  LKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLL---EHLKLEN 617

Query: 784  ERLGQQQRDMEEERSRQQEVIGKMEARLNE-QSRLLEQERWRVTAEQSKA---ESMQRAL 839
              L QQ   + E + R  +  G++ A+L   ++ +L+QE   +  +++K    E +QR L
Sbjct: 618  VSLSQQ---LTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRL 674

Query: 840  EE--QRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSK 897
            EE    +   Q+MA   A LE+     LE+ K  +L+  ++   L  E  +   Q  L++
Sbjct: 675  EEFEGERERLQRMADSAASLEQQ----LEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQ 730

Query: 898  ERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELR 957
            E        ALQ    RE +L +L     EL+ R  EL+ E        A+ E     L+
Sbjct: 731  E--------ALQ---SREQSLDALQTHYDELQARLGELQGEA-------ASREDTICLLQ 772

Query: 958  LEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQE 1017
             EK  + A     K   EE++  ++   E  EE    L + ++  A +  +++ +QQ+  
Sbjct: 773  NEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETA 832

Query: 1018 RLRKQEQHMHQEHLSLAQQRLQLDRARQDLPS 1049
             L+KQ Q + ++ L   QQ++ ++  R+D  S
Sbjct: 833  ALKKQMQKIKEQFL---QQKVMVEAYRRDATS 861



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 130/559 (23%), Positives = 245/559 (43%), Gaps = 80/559 (14%)

Query: 543  QPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELE 602
            Q ++ E+  R      +   +L A + +L     EL+ EL+         EA++ +L  E
Sbjct: 848  QKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHRE 907

Query: 603  RAQHELLLGSLQQQHQADLE-LIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQC 661
             AQ         +QH ADLE  ++SA + R + +ET  Q     L+ + E++ A  +++ 
Sbjct: 908  VAQ--------VRQHMADLEGHLQSAQKERDE-METHLQS----LQFDKEQMVA--VTEA 952

Query: 662  QEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDR 721
             EA + + E   Q  R+  AI ++K Q+M RL     ++  +M+  H+     + +L  R
Sbjct: 953  NEALKKQIEELQQEARK--AITEQK-QKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRR 1009

Query: 722  EVDAATSATSHTRSLNSIIHQMEKFSSSL--HELSSRVEA-----SHLTTSQERELG--I 772
              +A  +  +    L  +  Q     SSL  HE    +EA     SH  T  E+EL   I
Sbjct: 1010 LQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVI 1069

Query: 773  RQRDEQLRALQERLGQQQRDMEEERSRQQEV-----------------------IGKMEA 809
                ++L   +E++ + + +++E R  ++++                       +G+  A
Sbjct: 1070 ALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNA 1129

Query: 810  RLNEQSRLLE-----QERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAK--- 861
             L E + +LE     +E   V         +QR  EE R++     A++ A LE+ K   
Sbjct: 1130 ALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQ-ASLEKEKEKV 1188

Query: 862  SALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISL 921
            ++L E+  +  ++ G  RR   A   E S            E ++ LQ    +E  +  L
Sbjct: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELS------------EVKKELQA---KEHLVQKL 1233

Query: 922  AKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMS 981
              E  +L+IR  +   E  Q  AE   L + R +L+L +++++    +  +  +E+E++ 
Sbjct: 1234 QAEADDLQIREGKHSQEIAQFQAE---LAEARAQLQLLQKQLDEQLSKQPVGNQEMENLK 1290

Query: 982  KVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQ-RLQL 1040
                +K  E +   ++    + + +  L+ +QQ  + + K E  M QE LS+ Q+ +  L
Sbjct: 1291 WEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNV-KSELEMAQEDLSMTQKDKFML 1349

Query: 1041 DRARQDLPSSLVGLFPRAQ 1059
                 +L +++  L  + Q
Sbjct: 1350 QAKVSELKNNMKTLLQQNQ 1368



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 126/569 (22%), Positives = 222/569 (39%), Gaps = 89/569 (15%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHS---QARLAELEAQVRKLE----LERAQHELLLG 611
            +  KQL   Q  LQ     L A   H    QARL EL+ +    E    L + +  +L  
Sbjct: 721  DLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEA 780

Query: 612  SLQQQHQADLELIESAHRSRIKVLETS-------------------YQQREERLRRENEE 652
            +LQ       EL   A R      ETS                    QQ    L+++ ++
Sbjct: 781  ALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840

Query: 653  LSARYLSQCQEAEQARAELTAQHQ---------RRLAAIAQEKDQEMERLRELQRASILD 703
            +  ++L Q    E  R + T++ Q         +RL +  +E  QE+ ++   +R +  +
Sbjct: 841  IKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAE 900

Query: 704  MRRDHEEQLQRLKLLKDREVDAATSAT------SHTRSLNSIIHQMEKFSSSLHELSSRV 757
            + R H E  Q  + + D E    ++        +H +SL     QM   + +   L  ++
Sbjct: 901  LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQI 960

Query: 758  EASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNE---- 813
            E       QE    I ++ +++R L   L   Q++M+ +    +  +G +  RL E    
Sbjct: 961  EE----LQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAA 1016

Query: 814  ------------------QSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERA 855
                               S L   ER +    + +A S  + L E  K   + +A+   
Sbjct: 1017 KEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLE--KELQEVIALTSQ 1074

Query: 856  ELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAE-----------REA 904
            ELE ++  +LE +  +    G  ++    E +      +L  E+ +           RE 
Sbjct: 1075 ELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREH 1134

Query: 905  ERALQVD-TQREGTLISLAKE-QAELKIRASELRAEEKQLAAERAALEQERQELRLEKER 962
               L+    +RE  L+ L  + QA L+ +  E R  +  + A +A+LE+E++++   KE+
Sbjct: 1135 NSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQ 1194

Query: 963  INATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQ 1022
            + A  +         ++ S   SE  +E +      Q++QAE           Q R  K 
Sbjct: 1195 VAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAE-------ADDLQIREGKH 1247

Query: 1023 EQHMHQEHLSLAQQRLQLDRARQDLPSSL 1051
             Q + Q    LA+ R QL   ++ L   L
Sbjct: 1248 SQEIAQFQAELAEARAQLQLLQKQLDEQL 1276



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 113/489 (23%), Positives = 216/489 (44%), Gaps = 56/489 (11%)

Query: 579  QAELLHSQARLAELEAQVRKLELERAQHELL-LGSLQQQHQADLELIESAH------RSR 631
            Q   L SQ +  +LE      +L+ +Q E+  L S++Q +Q  L L + A        + 
Sbjct: 539  QMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAH 598

Query: 632  IKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEME 691
            I+V + +     E L+ EN  LS +       + + +  + AQ Q      A   DQE  
Sbjct: 599  IQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQ---GIEADMLDQEAA 655

Query: 692  RLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLH 751
             + ++Q A  + +  D + +L+  +  ++R    A SA S       +  Q+E+   +L 
Sbjct: 656  FM-QIQEAKTM-VEEDLQRRLEEFEGERERLQRMADSAAS-------LEQQLEQVKLTLL 706

Query: 752  ELSSRVEA---SHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKME 808
            +   ++EA    HL   ++  L      E L++ ++ L   Q   +E ++R  E+ G+  
Sbjct: 707  QRDQQLEALQQEHLDLMKQLTL----TQEALQSREQSLDALQTHYDELQARLGELQGEAA 762

Query: 809  AR------LNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKS 862
            +R      L  +  +LE       + + + +   R LEE  + T++ +   R EL   KS
Sbjct: 763  SREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELA-IKS 821

Query: 863  ALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLA 922
              +E  +       ++ +++  ++     QQK+  E   R+A    Q        LIS  
Sbjct: 822  GQVEHLQQETAALKKQMQKIKEQFL----QQKVMVEAYRRDATSKDQ--------LIS-- 867

Query: 923  KEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSK 982
                ELK     L +E K+L  E   +  E++    E  R++    +V+    ++E   +
Sbjct: 868  ----ELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQ 923

Query: 983  VASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQE-HLSLAQQRLQLD 1041
             A ++ +E E  L   Q +Q +++ ++ AV +  E L+KQ + + QE   ++ +Q+ ++ 
Sbjct: 924  SAQKERDEMETHL---QSLQFDKE-QMVAVTEANEALKKQIEELQQEARKAITEQKQKMR 979

Query: 1042 RARQDLPSS 1050
            R   DL S+
Sbjct: 980  RLGSDLTSA 988



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 48/203 (23%), Positives = 87/203 (42%), Gaps = 19/203 (9%)

Query: 861  KSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLIS 920
            ++A  E Q       GE R R  +  +  S +   S    + E  + L+   + EG L +
Sbjct: 366  QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLES--SAAETQEEMLQVLKEKMRLEGQLEA 423

Query: 921  LA-------KEQAELKIRASELRAEEKQLAAERAALEQERQE-LRLEKERINATALRVKL 972
            L+       KE+AEL+ + + L + + Q   E +   Q+RQ+ L  E + +  +   ++ 
Sbjct: 424  LSLEASQALKEKAELQAQLAAL-STKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLER 482

Query: 973  RAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQA-VQQQQERLRKQEQHMH---Q 1028
               ++++M +  +         L    QV  EQ  RL A V+  Q  +  ++  +H   Q
Sbjct: 483  AMTDLQNMLEAKNASLASSNNDL----QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQ 538

Query: 1029 EHLSLAQQRLQLDRARQDLPSSL 1051
            +  +L  Q  Q+   R  L S L
Sbjct: 539  QMTALQSQLQQVQLERTTLTSKL 561


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 130/524 (24%), Positives = 226/524 (43%), Gaps = 62/524 (11%)

Query: 567  AQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIES 626
            A+ +LQ      +A++   +  L  LE Q  KL  ER   E  L     Q   + E ++S
Sbjct: 990  ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1049

Query: 627  AHRSRIKVLETSYQQREERLRRENE-----------------ELSARYLSQCQEAEQARA 669
             ++ R+K  E +    E+RLR+E +                 EL  + + Q Q AE+ RA
Sbjct: 1050 LNKLRLKY-EATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1108

Query: 670  ELTAQHQRRLAAIAQEKD------QEMERLRELQRASILDMRRDHE-EQLQRLKLLKDR- 721
            +L  + +   AA+A+ +D      Q ++ LRE Q A++ + + D E E++ R K  K R 
Sbjct: 1109 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQ-AALAEAQEDLESERVARTKAEKQRR 1167

Query: 722  ----EVDAATSATSHTR-SLNSIIHQMEKFSSSLHELSSRVEAS---HLTTSQERELGIR 773
                E++A       T  S N+      K    + EL   +E     H    QE    +R
Sbjct: 1168 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE----LR 1223

Query: 774  QRDEQ-LRALQERLGQQQRDM---EEERSRQQEVIGKMEARLNEQSRLL---EQERWRVT 826
            QR  Q L  L E+L Q +R     E+ R   +  + ++ A L+         EQ R R+ 
Sbjct: 1224 QRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE 1283

Query: 827  AEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLE-EQKSVMLKCGEERRRLAAE 885
             +  + +      E  R   A+++   +AELE    AL E E K++ L      + L++ 
Sbjct: 1284 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLS-----KELSST 1338

Query: 886  WAEFSAQQKLSKERAERE---AERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQL 942
             A+    Q+L +E    +     R   ++ +  G    L +E A  +    EL+  + QL
Sbjct: 1339 EAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL 1398

Query: 943  AAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQ 1002
            +  R   E+E   L   +E     A        E E++++  +EK E  +R  R  +++Q
Sbjct: 1399 SEWRRRQEEEAGALEAGEEARRRAA-------REAEALTQRLAEKTETVDRLERGRRRLQ 1451

Query: 1003 AEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQD 1046
             E       ++QQ++ +   E+   +    LA+++  + RA ++
Sbjct: 1452 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1495



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 125/549 (22%), Positives = 230/549 (41%), Gaps = 77/549 (14%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            Q ++L A+ Q      ELQ +   S   + EL+ +V +LE ERA+       L +Q +A+
Sbjct: 875  QDEVLQARAQELQKVQELQQQ---SAREVGELQGRVAQLEEERAR-------LAEQLRAE 924

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARY--LSQCQEAEQARAELTAQHQRR 678
             EL   A  +R ++       R++ L     EL AR     +C    Q   +   QH + 
Sbjct: 925  AELCAEAEETRGRLAA-----RKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQE 979

Query: 679  LAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRL-----------KLLKDREVDAAT 727
            L A  + ++   ++L +L++ +     +  EE L  L           KLL+DR  + ++
Sbjct: 980  LEAHLEAEEGARQKL-QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1038

Query: 728  SATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLG 787
             A      + S+     K+ +++ ++  R+        ++ E G     ++L  L+ RL 
Sbjct: 1039 QAAEEEEKVKSLNKLRLKYEATIADMEDRL--------RKEEKG----RQELEKLKRRLD 1086

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTA 847
             +  +++E+   QQ+   ++ A+L  +   L+    R   E      + ++L E +   A
Sbjct: 1087 GESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA 1146

Query: 848  QQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEF----SAQQKLSKERAER- 902
            +  A E  E ER      E+Q+  +   GEE   L  E  +     +AQQ+L  +R +  
Sbjct: 1147 E--AQEDLESERVARTKAEKQRRDL---GEELEALRGELEDTLDSTNAQQELRSKREQEV 1201

Query: 903  -EAERALQVDT-----------QREGTLISLAKEQAELKIRAS--------ELRAEEKQL 942
             E ++ L+ +T           QR G  +    EQ E   R           L AE  +L
Sbjct: 1202 TELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1261

Query: 943  AAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQ 1002
             AE ++L+  RQE    + R+      V+ RA + E     A+EK +  +  L       
Sbjct: 1262 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1321

Query: 1003 AEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQ---RLQLDRARQDLPSSLVGLFPRAQ 1059
             E +++   + ++   L   E  +H     L ++   +L L    + + +   GL  + +
Sbjct: 1322 NEAESKTIRLSKE---LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLE 1378

Query: 1060 GPAASSQSA 1068
              AA+ + A
Sbjct: 1379 EEAAARERA 1387



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 172/757 (22%), Positives = 312/757 (41%), Gaps = 121/757 (15%)

Query: 399  GAGSPAKASQASKLRASKEEKEDWLSHALSRKKSQGLAREQHAGTSEG-LHLAGTAGHPP 457
            G G  A+A  A KL+ ++ E E+ +S AL+  +S+ +   +   ++E  LH A       
Sbjct: 1294 GDGERARAEAAEKLQRAQAELEN-VSGALNEAESKTIRLSKELSSTEAQLHDA------- 1345

Query: 458  SGSQPLTSTQGLEHAAAGGSSGTTARERPCVRPGVSGSPVTQNHAASALPTGSP------ 511
               Q L   +     A G        E   +R  +      +  A   L T         
Sbjct: 1346 ---QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1402

Query: 512  -KRGTAPGDLSATEPATCFPSTQKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLAAQVQ 570
             ++    G L A E A    + +              E+L + L   TE   +L   + +
Sbjct: 1403 RRQEEEAGALEAGEEARRRAAREA-------------EALTQRLAEKTETVDRLERGRRR 1449

Query: 571  LQCSPAELQAELLHSQARLAELEAQVRKLELERAQHEL-LLGSLQQQHQADLELIESAHR 629
            LQ    +   +L   +  ++ LE + RK +   A+ +  +L +++++ +A+ E  E   R
Sbjct: 1450 LQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREAR 1509

Query: 630  --SRIKVLETSYQQREERLRRENEELSARYLS-----------------QCQEAEQARAE 670
              S  + LE   + REE L R+N  L A   +                  C+ AEQA  +
Sbjct: 1510 ALSLTRALEEEQEAREE-LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAND 1568

Query: 671  LTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRD--------HEEQLQRLKLLKDRE 722
            L AQ       +   +D ++ RL    +A      RD         E + Q  K L+D E
Sbjct: 1569 LRAQVTELEDELTAAEDAKL-RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAE 1627

Query: 723  VDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRAL 782
            V+        T ++ +     +K    L EL +++ ++     Q +E  ++Q    LR +
Sbjct: 1628 VERDEERKQRTLAVAA----RKKLEGELEELKAQMASA----GQGKEEAVKQ----LRKM 1675

Query: 783  QERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ 842
            Q ++ +  R++EE R+ ++E+  +      ++ + LE E  R+  E + ++  +R  ++ 
Sbjct: 1676 QAQMKELWREVEETRTSREEIFSQ-NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQD 1734

Query: 843  RKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEF------------- 889
            R     +MA E A    +K+A+LEE++ +  + G+    L  E +               
Sbjct: 1735 R----DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1790

Query: 890  --SAQQKLSKER---AEREAERALQVDTQREGTLISLAKEQAELKIRAS-ELRAEEKQLA 943
              S   +LS ER   A+ E+ R  Q++ Q +     L +E A  + R    + A E +LA
Sbjct: 1791 VESLTTELSAERSFSAKAESGRQ-QLERQIQELRGRLGEEDAGARARHKMTIAALESKLA 1849

Query: 944  AERAALEQERQELRLEKERINATALRVK---LRAEEVESMSKVASEKYEEG-------ER 993
                 LEQE +E  L  + +     R+K   L+ EE   ++    ++ E+G       +R
Sbjct: 1850 QAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR 1909

Query: 994  ALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVG 1053
             L EA++  +  QA  + +Q++ E + +  + M++E  +L   R +L R      +  V 
Sbjct: 1910 QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTL---RNRLRRGPLTFTTRTVR 1966

Query: 1054 LFPRAQGPAASSQSALMPPAPTTRWCSQPPTGLDPSP 1090
               R +   AS + A           +QP +G  P P
Sbjct: 1967 QVFRLEEGVASDEEAEE---------AQPGSGPSPEP 1994



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 158/668 (23%), Positives = 274/668 (41%), Gaps = 70/668 (10%)

Query: 408  QASKLRASKEEKEDWLSHALSRKKSQGLAREQHAGTSEGLHLAGTAGHPPSGSQPLTSTQ 467
            +A +LRA    KE+ L  AL+R + +G AR Q   +      A         S+ +  T+
Sbjct: 1102 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1161

Query: 468  GLEHAAAGGSSGTTARERPCVRPGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEPAT 527
              +     G      R       G     +   +A   L +   +  T        E   
Sbjct: 1162 AEKQRRDLGEELEALR-------GELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRI 1214

Query: 528  CFPSTQKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQA 587
               + Q+  +        L E L ++      ++K  LA + ++    +EL+AEL   Q 
Sbjct: 1215 HEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV----SELRAELSSLQT 1270

Query: 588  RLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLR 647
               E E + R+LEL+  + +   G  ++      E ++ A ++ ++ +  +  + E +  
Sbjct: 1271 ARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA-QAELENVSGALNEAESKTI 1329

Query: 648  RENEELSAR--YLSQCQEA--EQARAELTAQHQRRL-----AAIAQEKDQEM---ERL-R 694
            R ++ELS+    L   QE   E+ RA+L    + R      A + ++ ++E    ER  R
Sbjct: 1330 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1389

Query: 695  ELQ--RASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHE 752
            ELQ  +A + + RR  EE+   L+  ++    AA  A + T+ L      +++       
Sbjct: 1390 ELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR 1449

Query: 753  LSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM---EEERSRQQEVIGKMEA 809
            L   ++ + +   Q+R+L +   +++ R   + L +++  +    EER R +    + EA
Sbjct: 1450 LQQELDDATMDLEQQRQL-VSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1508

Query: 810  RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQK 869
            R    +R LE+E                  +E R+   +Q    RAELE    ALL  + 
Sbjct: 1509 RALSLTRALEEE------------------QEAREELERQNRALRAELE----ALLSSKD 1546

Query: 870  SVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQ-REGTLISLAKEQAEL 928
             V     E  R  A   AE +A   L  +  E E E     D + R    +   K Q E 
Sbjct: 1547 DVGKSVHELER--ACRVAEQAAND-LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1603

Query: 929  KIRASELRAEEK--QLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVAS- 985
             ++  +   EE+  QLA +    E ER E R  K+R  A A R KL  E  E  +++AS 
Sbjct: 1604 DLQGRDEAGEERRRQLAKQLRDAEVERDEER--KQRTLAVAARKKLEGELEELKAQMASA 1661

Query: 986  -EKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQH-------MHQEHLSLAQQR 1037
             +  EE  + LR+ Q    E    ++  +  +E +  Q +        +  E L L ++ 
Sbjct: 1662 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1721

Query: 1038 LQLDRARQ 1045
               DRAR+
Sbjct: 1722 AASDRARR 1729



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 126/550 (22%), Positives = 232/550 (42%), Gaps = 60/550 (10%)

Query: 550  LARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELL 609
            LA  L    E   +    + +L     EL+  +   +AR+ E E   R+++ E+ + +  
Sbjct: 917  LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH 976

Query: 610  LGSLQQQHQAD------LELIESAHRSRIKVLETS---YQQREERLRREN---EELSARY 657
            +  L+   +A+      L+L +    +++K  E      + +  +L +E    E+  A +
Sbjct: 977  IQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEF 1036

Query: 658  LSQCQEAEQARAELTAQHQRRLAAIAQEKD---------QEMERLRELQRASILDMRRDH 708
             SQ  E E+    L     +  A IA  +D         QE+E+L+        +++   
Sbjct: 1037 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1096

Query: 709  EEQLQRLKLL------KDREVDAATSAT-----SHTRSLNSIIHQMEKFSSSLHELSSRV 757
             EQ QR + L      K+ E+ AA +       +  + L S+       + +  +L S  
Sbjct: 1097 VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESER 1156

Query: 758  EASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRL 817
             A      Q R+LG  +  E LR   E         +E RS++++ + +++  L E++R+
Sbjct: 1157 VARTKAEKQRRDLG--EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRI 1214

Query: 818  LE-----------QERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLE 866
             E           Q    +  +  +A   + A E+ R     +++  RAEL   ++A  E
Sbjct: 1215 HEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQE 1274

Query: 867  EQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQA 926
             +        + RRRL  +  E   +     ERA  EA   LQ   Q E   +S A  +A
Sbjct: 1275 GE--------QRRRRLELQLQEVQGRAG-DGERARAEAAEKLQ-RAQAELENVSGALNEA 1324

Query: 927  ELK-IRAS-ELRAEEKQLAAERAALEQE-RQELRL--EKERINATALRVKLRAEEVESMS 981
            E K IR S EL + E QL   +  L++E R +L L      + A A  ++ + EE  +  
Sbjct: 1325 ESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAAR 1384

Query: 982  KVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLD 1041
            + A  + +  +  L E ++ Q E+   L+A ++ + R  ++ + + Q      +   +L+
Sbjct: 1385 ERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE 1444

Query: 1042 RARQDLPSSL 1051
            R R+ L   L
Sbjct: 1445 RGRRRLQQEL 1454


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 130/524 (24%), Positives = 226/524 (43%), Gaps = 62/524 (11%)

Query: 567  AQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIES 626
            A+ +LQ      +A++   +  L  LE Q  KL  ER   E  L     Q   + E ++S
Sbjct: 982  ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1041

Query: 627  AHRSRIKVLETSYQQREERLRRENE-----------------ELSARYLSQCQEAEQARA 669
             ++ R+K  E +    E+RLR+E +                 EL  + + Q Q AE+ RA
Sbjct: 1042 LNKLRLKY-EATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1100

Query: 670  ELTAQHQRRLAAIAQEKD------QEMERLRELQRASILDMRRDHE-EQLQRLKLLKDR- 721
            +L  + +   AA+A+ +D      Q ++ LRE Q A++ + + D E E++ R K  K R 
Sbjct: 1101 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQ-AALAEAQEDLESERVARTKAEKQRR 1159

Query: 722  ----EVDAATSATSHTR-SLNSIIHQMEKFSSSLHELSSRVEAS---HLTTSQERELGIR 773
                E++A       T  S N+      K    + EL   +E     H    QE    +R
Sbjct: 1160 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE----LR 1215

Query: 774  QRDEQ-LRALQERLGQQQRDM---EEERSRQQEVIGKMEARLNEQSRLL---EQERWRVT 826
            QR  Q L  L E+L Q +R     E+ R   +  + ++ A L+         EQ R R+ 
Sbjct: 1216 QRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE 1275

Query: 827  AEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLE-EQKSVMLKCGEERRRLAAE 885
             +  + +      E  R   A+++   +AELE    AL E E K++ L      + L++ 
Sbjct: 1276 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLS-----KELSST 1330

Query: 886  WAEFSAQQKLSKERAERE---AERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQL 942
             A+    Q+L +E    +     R   ++ +  G    L +E A  +    EL+  + QL
Sbjct: 1331 EAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL 1390

Query: 943  AAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQ 1002
            +  R   E+E   L   +E     A        E E++++  +EK E  +R  R  +++Q
Sbjct: 1391 SEWRRRQEEEAGALEAGEEARRRAA-------REAEALTQRLAEKTETVDRLERGRRRLQ 1443

Query: 1003 AEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQD 1046
             E       ++QQ++ +   E+   +    LA+++  + RA ++
Sbjct: 1444 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1487



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 125/549 (22%), Positives = 230/549 (41%), Gaps = 77/549 (14%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            Q ++L A+ Q      ELQ +   S   + EL+ +V +LE ERA+       L +Q +A+
Sbjct: 867  QDEVLQARAQELQKVQELQQQ---SAREVGELQGRVAQLEEERAR-------LAEQLRAE 916

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARY--LSQCQEAEQARAELTAQHQRR 678
             EL   A  +R ++       R++ L     EL AR     +C    Q   +   QH + 
Sbjct: 917  AELCAEAEETRGRLAA-----RKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQE 971

Query: 679  LAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRL-----------KLLKDREVDAAT 727
            L A  + ++   ++L +L++ +     +  EE L  L           KLL+DR  + ++
Sbjct: 972  LEAHLEAEEGARQKL-QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1030

Query: 728  SATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLG 787
             A      + S+     K+ +++ ++  R+        ++ E G     ++L  L+ RL 
Sbjct: 1031 QAAEEEEKVKSLNKLRLKYEATIADMEDRL--------RKEEKG----RQELEKLKRRLD 1078

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTA 847
             +  +++E+   QQ+   ++ A+L  +   L+    R   E      + ++L E +   A
Sbjct: 1079 GESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA 1138

Query: 848  QQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEF----SAQQKLSKERAER- 902
            +  A E  E ER      E+Q+  +   GEE   L  E  +     +AQQ+L  +R +  
Sbjct: 1139 E--AQEDLESERVARTKAEKQRRDL---GEELEALRGELEDTLDSTNAQQELRSKREQEV 1193

Query: 903  -EAERALQVDT-----------QREGTLISLAKEQAELKIRAS--------ELRAEEKQL 942
             E ++ L+ +T           QR G  +    EQ E   R           L AE  +L
Sbjct: 1194 TELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1253

Query: 943  AAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQ 1002
             AE ++L+  RQE    + R+      V+ RA + E     A+EK +  +  L       
Sbjct: 1254 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1313

Query: 1003 AEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQ---RLQLDRARQDLPSSLVGLFPRAQ 1059
             E +++   + ++   L   E  +H     L ++   +L L    + + +   GL  + +
Sbjct: 1314 NEAESKTIRLSKE---LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLE 1370

Query: 1060 GPAASSQSA 1068
              AA+ + A
Sbjct: 1371 EEAAARERA 1379



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 172/757 (22%), Positives = 312/757 (41%), Gaps = 121/757 (15%)

Query: 399  GAGSPAKASQASKLRASKEEKEDWLSHALSRKKSQGLAREQHAGTSEG-LHLAGTAGHPP 457
            G G  A+A  A KL+ ++ E E+ +S AL+  +S+ +   +   ++E  LH A       
Sbjct: 1286 GDGERARAEAAEKLQRAQAELEN-VSGALNEAESKTIRLSKELSSTEAQLHDA------- 1337

Query: 458  SGSQPLTSTQGLEHAAAGGSSGTTARERPCVRPGVSGSPVTQNHAASALPTGSP------ 511
               Q L   +     A G        E   +R  +      +  A   L T         
Sbjct: 1338 ---QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1394

Query: 512  -KRGTAPGDLSATEPATCFPSTQKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLAAQVQ 570
             ++    G L A E A    + +              E+L + L   TE   +L   + +
Sbjct: 1395 RRQEEEAGALEAGEEARRRAAREA-------------EALTQRLAEKTETVDRLERGRRR 1441

Query: 571  LQCSPAELQAELLHSQARLAELEAQVRKLELERAQHEL-LLGSLQQQHQADLELIESAHR 629
            LQ    +   +L   +  ++ LE + RK +   A+ +  +L +++++ +A+ E  E   R
Sbjct: 1442 LQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREAR 1501

Query: 630  --SRIKVLETSYQQREERLRRENEELSARYLS-----------------QCQEAEQARAE 670
              S  + LE   + REE L R+N  L A   +                  C+ AEQA  +
Sbjct: 1502 ALSLTRALEEEQEAREE-LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAND 1560

Query: 671  LTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRD--------HEEQLQRLKLLKDRE 722
            L AQ       +   +D ++ RL    +A      RD         E + Q  K L+D E
Sbjct: 1561 LRAQVTELEDELTAAEDAKL-RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAE 1619

Query: 723  VDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRAL 782
            V+        T ++ +     +K    L EL +++ ++     Q +E  ++Q    LR +
Sbjct: 1620 VERDEERKQRTLAVAA----RKKLEGELEELKAQMASA----GQGKEEAVKQ----LRKM 1667

Query: 783  QERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ 842
            Q ++ +  R++EE R+ ++E+  +      ++ + LE E  R+  E + ++  +R  ++ 
Sbjct: 1668 QAQMKELWREVEETRTSREEIFSQ-NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQD 1726

Query: 843  RKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEF------------- 889
            R     +MA E A    +K+A+LEE++ +  + G+    L  E +               
Sbjct: 1727 R----DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1782

Query: 890  --SAQQKLSKER---AEREAERALQVDTQREGTLISLAKEQAELKIRAS-ELRAEEKQLA 943
              S   +LS ER   A+ E+ R  Q++ Q +     L +E A  + R    + A E +LA
Sbjct: 1783 VESLTTELSAERSFSAKAESGRQ-QLERQIQELRGRLGEEDAGARARHKMTIAALESKLA 1841

Query: 944  AERAALEQERQELRLEKERINATALRVK---LRAEEVESMSKVASEKYEEG-------ER 993
                 LEQE +E  L  + +     R+K   L+ EE   ++    ++ E+G       +R
Sbjct: 1842 QAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR 1901

Query: 994  ALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVG 1053
             L EA++  +  QA  + +Q++ E + +  + M++E  +L   R +L R      +  V 
Sbjct: 1902 QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTL---RNRLRRGPLTFTTRTVR 1958

Query: 1054 LFPRAQGPAASSQSALMPPAPTTRWCSQPPTGLDPSP 1090
               R +   AS + A           +QP +G  P P
Sbjct: 1959 QVFRLEEGVASDEEAEE---------AQPGSGPSPEP 1986



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 158/668 (23%), Positives = 274/668 (41%), Gaps = 70/668 (10%)

Query: 408  QASKLRASKEEKEDWLSHALSRKKSQGLAREQHAGTSEGLHLAGTAGHPPSGSQPLTSTQ 467
            +A +LRA    KE+ L  AL+R + +G AR Q   +      A         S+ +  T+
Sbjct: 1094 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1153

Query: 468  GLEHAAAGGSSGTTARERPCVRPGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEPAT 527
              +     G      R       G     +   +A   L +   +  T        E   
Sbjct: 1154 AEKQRRDLGEELEALR-------GELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRI 1206

Query: 528  CFPSTQKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQA 587
               + Q+  +        L E L ++      ++K  LA + ++    +EL+AEL   Q 
Sbjct: 1207 HEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV----SELRAELSSLQT 1262

Query: 588  RLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLR 647
               E E + R+LEL+  + +   G  ++      E ++ A ++ ++ +  +  + E +  
Sbjct: 1263 ARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA-QAELENVSGALNEAESKTI 1321

Query: 648  RENEELSAR--YLSQCQEA--EQARAELTAQHQRRL-----AAIAQEKDQEM---ERL-R 694
            R ++ELS+    L   QE   E+ RA+L    + R      A + ++ ++E    ER  R
Sbjct: 1322 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1381

Query: 695  ELQ--RASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHE 752
            ELQ  +A + + RR  EE+   L+  ++    AA  A + T+ L      +++       
Sbjct: 1382 ELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR 1441

Query: 753  LSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM---EEERSRQQEVIGKMEA 809
            L   ++ + +   Q+R+L +   +++ R   + L +++  +    EER R +    + EA
Sbjct: 1442 LQQELDDATMDLEQQRQL-VSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1500

Query: 810  RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQK 869
            R    +R LE+E                  +E R+   +Q    RAELE    ALL  + 
Sbjct: 1501 RALSLTRALEEE------------------QEAREELERQNRALRAELE----ALLSSKD 1538

Query: 870  SVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQ-REGTLISLAKEQAEL 928
             V     E  R  A   AE +A   L  +  E E E     D + R    +   K Q E 
Sbjct: 1539 DVGKSVHELER--ACRVAEQAAND-LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1595

Query: 929  KIRASELRAEEK--QLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVAS- 985
             ++  +   EE+  QLA +    E ER E R  K+R  A A R KL  E  E  +++AS 
Sbjct: 1596 DLQGRDEAGEERRRQLAKQLRDAEVERDEER--KQRTLAVAARKKLEGELEELKAQMASA 1653

Query: 986  -EKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQH-------MHQEHLSLAQQR 1037
             +  EE  + LR+ Q    E    ++  +  +E +  Q +        +  E L L ++ 
Sbjct: 1654 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1713

Query: 1038 LQLDRARQ 1045
               DRAR+
Sbjct: 1714 AASDRARR 1721



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 126/550 (22%), Positives = 232/550 (42%), Gaps = 60/550 (10%)

Query: 550  LARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELL 609
            LA  L    E   +    + +L     EL+  +   +AR+ E E   R+++ E+ + +  
Sbjct: 909  LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH 968

Query: 610  LGSLQQQHQAD------LELIESAHRSRIKVLETS---YQQREERLRREN---EELSARY 657
            +  L+   +A+      L+L +    +++K  E      + +  +L +E    E+  A +
Sbjct: 969  IQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEF 1028

Query: 658  LSQCQEAEQARAELTAQHQRRLAAIAQEKD---------QEMERLRELQRASILDMRRDH 708
             SQ  E E+    L     +  A IA  +D         QE+E+L+        +++   
Sbjct: 1029 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1088

Query: 709  EEQLQRLKLL------KDREVDAATSAT-----SHTRSLNSIIHQMEKFSSSLHELSSRV 757
             EQ QR + L      K+ E+ AA +       +  + L S+       + +  +L S  
Sbjct: 1089 VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESER 1148

Query: 758  EASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRL 817
             A      Q R+LG  +  E LR   E         +E RS++++ + +++  L E++R+
Sbjct: 1149 VARTKAEKQRRDLG--EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRI 1206

Query: 818  LE-----------QERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLE 866
             E           Q    +  +  +A   + A E+ R     +++  RAEL   ++A  E
Sbjct: 1207 HEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQE 1266

Query: 867  EQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQA 926
             +        + RRRL  +  E   +     ERA  EA   LQ   Q E   +S A  +A
Sbjct: 1267 GE--------QRRRRLELQLQEVQGRAG-DGERARAEAAEKLQ-RAQAELENVSGALNEA 1316

Query: 927  ELK-IRAS-ELRAEEKQLAAERAALEQE-RQELRL--EKERINATALRVKLRAEEVESMS 981
            E K IR S EL + E QL   +  L++E R +L L      + A A  ++ + EE  +  
Sbjct: 1317 ESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAAR 1376

Query: 982  KVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLD 1041
            + A  + +  +  L E ++ Q E+   L+A ++ + R  ++ + + Q      +   +L+
Sbjct: 1377 ERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE 1436

Query: 1042 RARQDLPSSL 1051
            R R+ L   L
Sbjct: 1437 RGRRRLQQEL 1446


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 130/524 (24%), Positives = 226/524 (43%), Gaps = 62/524 (11%)

Query: 567  AQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIES 626
            A+ +LQ      +A++   +  L  LE Q  KL  ER   E  L     Q   + E ++S
Sbjct: 1023 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1082

Query: 627  AHRSRIKVLETSYQQREERLRRENE-----------------ELSARYLSQCQEAEQARA 669
             ++ R+K  E +    E+RLR+E +                 EL  + + Q Q AE+ RA
Sbjct: 1083 LNKLRLKY-EATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1141

Query: 670  ELTAQHQRRLAAIAQEKD------QEMERLRELQRASILDMRRDHE-EQLQRLKLLKDR- 721
            +L  + +   AA+A+ +D      Q ++ LRE Q A++ + + D E E++ R K  K R 
Sbjct: 1142 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQ-AALAEAQEDLESERVARTKAEKQRR 1200

Query: 722  ----EVDAATSATSHTR-SLNSIIHQMEKFSSSLHELSSRVEAS---HLTTSQERELGIR 773
                E++A       T  S N+      K    + EL   +E     H    QE    +R
Sbjct: 1201 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE----LR 1256

Query: 774  QRDEQ-LRALQERLGQQQRDM---EEERSRQQEVIGKMEARLNEQSRLL---EQERWRVT 826
            QR  Q L  L E+L Q +R     E+ R   +  + ++ A L+         EQ R R+ 
Sbjct: 1257 QRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE 1316

Query: 827  AEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLE-EQKSVMLKCGEERRRLAAE 885
             +  + +      E  R   A+++   +AELE    AL E E K++ L      + L++ 
Sbjct: 1317 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLS-----KELSST 1371

Query: 886  WAEFSAQQKLSKERAERE---AERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQL 942
             A+    Q+L +E    +     R   ++ +  G    L +E A  +    EL+  + QL
Sbjct: 1372 EAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL 1431

Query: 943  AAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQ 1002
            +  R   E+E   L   +E     A        E E++++  +EK E  +R  R  +++Q
Sbjct: 1432 SEWRRRQEEEAGALEAGEEARRRAA-------REAEALTQRLAEKTETVDRLERGRRRLQ 1484

Query: 1003 AEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQD 1046
             E       ++QQ++ +   E+   +    LA+++  + RA ++
Sbjct: 1485 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1528



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 125/549 (22%), Positives = 230/549 (41%), Gaps = 77/549 (14%)

Query: 561  QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQAD 620
            Q ++L A+ Q      ELQ +   S   + EL+ +V +LE ERA+       L +Q +A+
Sbjct: 908  QDEVLQARAQELQKVQELQQQ---SAREVGELQGRVAQLEEERAR-------LAEQLRAE 957

Query: 621  LELIESAHRSRIKVLETSYQQREERLRRENEELSARY--LSQCQEAEQARAELTAQHQRR 678
             EL   A  +R ++       R++ L     EL AR     +C    Q   +   QH + 
Sbjct: 958  AELCAEAEETRGRLAA-----RKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQE 1012

Query: 679  LAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRL-----------KLLKDREVDAAT 727
            L A  + ++   ++L +L++ +     +  EE L  L           KLL+DR  + ++
Sbjct: 1013 LEAHLEAEEGARQKL-QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1071

Query: 728  SATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLG 787
             A      + S+     K+ +++ ++  R+        ++ E G     ++L  L+ RL 
Sbjct: 1072 QAAEEEEKVKSLNKLRLKYEATIADMEDRL--------RKEEKG----RQELEKLKRRLD 1119

Query: 788  QQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTA 847
             +  +++E+   QQ+   ++ A+L  +   L+    R   E      + ++L E +   A
Sbjct: 1120 GESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA 1179

Query: 848  QQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEF----SAQQKLSKERAER- 902
            +  A E  E ER      E+Q+  +   GEE   L  E  +     +AQQ+L  +R +  
Sbjct: 1180 E--AQEDLESERVARTKAEKQRRDL---GEELEALRGELEDTLDSTNAQQELRSKREQEV 1234

Query: 903  -EAERALQVDT-----------QREGTLISLAKEQAELKIRAS--------ELRAEEKQL 942
             E ++ L+ +T           QR G  +    EQ E   R           L AE  +L
Sbjct: 1235 TELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1294

Query: 943  AAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQ 1002
             AE ++L+  RQE    + R+      V+ RA + E     A+EK +  +  L       
Sbjct: 1295 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1354

Query: 1003 AEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQ---RLQLDRARQDLPSSLVGLFPRAQ 1059
             E +++   + ++   L   E  +H     L ++   +L L    + + +   GL  + +
Sbjct: 1355 NEAESKTIRLSKE---LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLE 1411

Query: 1060 GPAASSQSA 1068
              AA+ + A
Sbjct: 1412 EEAAARERA 1420



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 172/757 (22%), Positives = 312/757 (41%), Gaps = 121/757 (15%)

Query: 399  GAGSPAKASQASKLRASKEEKEDWLSHALSRKKSQGLAREQHAGTSEG-LHLAGTAGHPP 457
            G G  A+A  A KL+ ++ E E+ +S AL+  +S+ +   +   ++E  LH A       
Sbjct: 1327 GDGERARAEAAEKLQRAQAELEN-VSGALNEAESKTIRLSKELSSTEAQLHDA------- 1378

Query: 458  SGSQPLTSTQGLEHAAAGGSSGTTARERPCVRPGVSGSPVTQNHAASALPTGSP------ 511
               Q L   +     A G        E   +R  +      +  A   L T         
Sbjct: 1379 ---QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1435

Query: 512  -KRGTAPGDLSATEPATCFPSTQKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLAAQVQ 570
             ++    G L A E A    + +              E+L + L   TE   +L   + +
Sbjct: 1436 RRQEEEAGALEAGEEARRRAAREA-------------EALTQRLAEKTETVDRLERGRRR 1482

Query: 571  LQCSPAELQAELLHSQARLAELEAQVRKLELERAQHEL-LLGSLQQQHQADLELIESAHR 629
            LQ    +   +L   +  ++ LE + RK +   A+ +  +L +++++ +A+ E  E   R
Sbjct: 1483 LQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREAR 1542

Query: 630  --SRIKVLETSYQQREERLRRENEELSARYLS-----------------QCQEAEQARAE 670
              S  + LE   + REE L R+N  L A   +                  C+ AEQA  +
Sbjct: 1543 ALSLTRALEEEQEAREE-LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAND 1601

Query: 671  LTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRD--------HEEQLQRLKLLKDRE 722
            L AQ       +   +D ++ RL    +A      RD         E + Q  K L+D E
Sbjct: 1602 LRAQVTELEDELTAAEDAKL-RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAE 1660

Query: 723  VDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRAL 782
            V+        T ++ +     +K    L EL +++ ++     Q +E  ++Q    LR +
Sbjct: 1661 VERDEERKQRTLAVAA----RKKLEGELEELKAQMASA----GQGKEEAVKQ----LRKM 1708

Query: 783  QERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ 842
            Q ++ +  R++EE R+ ++E+  +      ++ + LE E  R+  E + ++  +R  ++ 
Sbjct: 1709 QAQMKELWREVEETRTSREEIFSQ-NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQD 1767

Query: 843  RKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEF------------- 889
            R     +MA E A    +K+A+LEE++ +  + G+    L  E +               
Sbjct: 1768 R----DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1823

Query: 890  --SAQQKLSKER---AEREAERALQVDTQREGTLISLAKEQAELKIRAS-ELRAEEKQLA 943
              S   +LS ER   A+ E+ R  Q++ Q +     L +E A  + R    + A E +LA
Sbjct: 1824 VESLTTELSAERSFSAKAESGRQ-QLERQIQELRGRLGEEDAGARARHKMTIAALESKLA 1882

Query: 944  AERAALEQERQELRLEKERINATALRVK---LRAEEVESMSKVASEKYEEG-------ER 993
                 LEQE +E  L  + +     R+K   L+ EE   ++    ++ E+G       +R
Sbjct: 1883 QAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR 1942

Query: 994  ALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVG 1053
             L EA++  +  QA  + +Q++ E + +  + M++E  +L   R +L R      +  V 
Sbjct: 1943 QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTL---RNRLRRGPLTFTTRTVR 1999

Query: 1054 LFPRAQGPAASSQSALMPPAPTTRWCSQPPTGLDPSP 1090
               R +   AS + A           +QP +G  P P
Sbjct: 2000 QVFRLEEGVASDEEAEE---------AQPGSGPSPEP 2027



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 158/668 (23%), Positives = 274/668 (41%), Gaps = 70/668 (10%)

Query: 408  QASKLRASKEEKEDWLSHALSRKKSQGLAREQHAGTSEGLHLAGTAGHPPSGSQPLTSTQ 467
            +A +LRA    KE+ L  AL+R + +G AR Q   +      A         S+ +  T+
Sbjct: 1135 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1194

Query: 468  GLEHAAAGGSSGTTARERPCVRPGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEPAT 527
              +     G      R       G     +   +A   L +   +  T        E   
Sbjct: 1195 AEKQRRDLGEELEALR-------GELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRI 1247

Query: 528  CFPSTQKPTEPSVPVQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQA 587
               + Q+  +        L E L ++      ++K  LA + ++    +EL+AEL   Q 
Sbjct: 1248 HEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV----SELRAELSSLQT 1303

Query: 588  RLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLR 647
               E E + R+LEL+  + +   G  ++      E ++ A ++ ++ +  +  + E +  
Sbjct: 1304 ARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA-QAELENVSGALNEAESKTI 1362

Query: 648  RENEELSAR--YLSQCQEA--EQARAELTAQHQRRL-----AAIAQEKDQEM---ERL-R 694
            R ++ELS+    L   QE   E+ RA+L    + R      A + ++ ++E    ER  R
Sbjct: 1363 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1422

Query: 695  ELQ--RASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHE 752
            ELQ  +A + + RR  EE+   L+  ++    AA  A + T+ L      +++       
Sbjct: 1423 ELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR 1482

Query: 753  LSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM---EEERSRQQEVIGKMEA 809
            L   ++ + +   Q+R+L +   +++ R   + L +++  +    EER R +    + EA
Sbjct: 1483 LQQELDDATMDLEQQRQL-VSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1541

Query: 810  RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQK 869
            R    +R LE+E                  +E R+   +Q    RAELE    ALL  + 
Sbjct: 1542 RALSLTRALEEE------------------QEAREELERQNRALRAELE----ALLSSKD 1579

Query: 870  SVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQ-REGTLISLAKEQAEL 928
             V     E  R  A   AE +A   L  +  E E E     D + R    +   K Q E 
Sbjct: 1580 DVGKSVHELER--ACRVAEQAAND-LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1636

Query: 929  KIRASELRAEEK--QLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVAS- 985
             ++  +   EE+  QLA +    E ER E R  K+R  A A R KL  E  E  +++AS 
Sbjct: 1637 DLQGRDEAGEERRRQLAKQLRDAEVERDEER--KQRTLAVAARKKLEGELEELKAQMASA 1694

Query: 986  -EKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQH-------MHQEHLSLAQQR 1037
             +  EE  + LR+ Q    E    ++  +  +E +  Q +        +  E L L ++ 
Sbjct: 1695 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1754

Query: 1038 LQLDRARQ 1045
               DRAR+
Sbjct: 1755 AASDRARR 1762



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 126/550 (22%), Positives = 232/550 (42%), Gaps = 60/550 (10%)

Query: 550  LARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELL 609
            LA  L    E   +    + +L     EL+  +   +AR+ E E   R+++ E+ + +  
Sbjct: 950  LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH 1009

Query: 610  LGSLQQQHQAD------LELIESAHRSRIKVLETS---YQQREERLRREN---EELSARY 657
            +  L+   +A+      L+L +    +++K  E      + +  +L +E    E+  A +
Sbjct: 1010 IQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEF 1069

Query: 658  LSQCQEAEQARAELTAQHQRRLAAIAQEKD---------QEMERLRELQRASILDMRRDH 708
             SQ  E E+    L     +  A IA  +D         QE+E+L+        +++   
Sbjct: 1070 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQM 1129

Query: 709  EEQLQRLKLL------KDREVDAATSAT-----SHTRSLNSIIHQMEKFSSSLHELSSRV 757
             EQ QR + L      K+ E+ AA +       +  + L S+       + +  +L S  
Sbjct: 1130 VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESER 1189

Query: 758  EASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRL 817
             A      Q R+LG  +  E LR   E         +E RS++++ + +++  L E++R+
Sbjct: 1190 VARTKAEKQRRDLG--EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRI 1247

Query: 818  LE-----------QERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLE 866
             E           Q    +  +  +A   + A E+ R     +++  RAEL   ++A  E
Sbjct: 1248 HEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQE 1307

Query: 867  EQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQA 926
             +        + RRRL  +  E   +     ERA  EA   LQ   Q E   +S A  +A
Sbjct: 1308 GE--------QRRRRLELQLQEVQGRAG-DGERARAEAAEKLQ-RAQAELENVSGALNEA 1357

Query: 927  ELK-IRAS-ELRAEEKQLAAERAALEQE-RQELRL--EKERINATALRVKLRAEEVESMS 981
            E K IR S EL + E QL   +  L++E R +L L      + A A  ++ + EE  +  
Sbjct: 1358 ESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAAR 1417

Query: 982  KVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLD 1041
            + A  + +  +  L E ++ Q E+   L+A ++ + R  ++ + + Q      +   +L+
Sbjct: 1418 ERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE 1477

Query: 1042 RARQDLPSSL 1051
            R R+ L   L
Sbjct: 1478 RGRRRLQQEL 1487


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapiens]
          Length = 436

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 83/447 (18%), Positives = 218/447 (48%), Gaps = 33/447 (7%)

Query: 590  AELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRE 649
            AEL+ +++ +E E+++ +L +  L+++ + D   I      +++  E   +++E ++R +
Sbjct: 14   AELQEELQLVETEKSEIQLHIKELKRKLETDK--IPLPQEGQVREQEGQVREQEGQVREQ 71

Query: 650  NEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLREL--QRASILDMRRD 707
              ++  +   Q +E E    E   Q + +   + +++ Q  E+  ++  Q   + +    
Sbjct: 72   EGQVREQE-GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 130

Query: 708  HEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRV-EASHLTTSQ 766
              EQ  +++  + +  +           +     Q+ +    + E   +V E       Q
Sbjct: 131  VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 190

Query: 767  ERELGIRQRDEQLRALQERLGQQQRDM---EEERSRQQEVIGKMEARLNEQSRLLEQERW 823
            E ++G  +++ Q+   +E++G+Q+  M   EE+   Q+E + K E ++ EQ   ++++  
Sbjct: 191  EGQMG--EQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEE 248

Query: 824  RVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLA 883
            +V     K E   R  EEQ +   +QM  +  ++ + K    +E+++     GE+  ++ 
Sbjct: 249  QV----QKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQT-----GEQEEQMR 299

Query: 884  AEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLA 943
             +  +   Q++  +E+ E+  E+  Q+  Q E     + +++ ++  +  ++  +E+Q+ 
Sbjct: 300  EQEEQMREQEEQMREQEEQMREQEEQMGKQEE----QMWEQKEQMWEQKEQMWKQEEQMG 355

Query: 944  AERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEE-GERALREAQQVQ 1002
             +   ++++ +++R ++E++     +++ + E++    +   E+ E+ GE+  +E  + Q
Sbjct: 356  EQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQ--KEQMREQ 413

Query: 1003 AEQQARLQAVQQQQERLRKQEQHMHQE 1029
             EQ        +Q+E++RKQE+HM ++
Sbjct: 414  EEQMG------EQKEQMRKQEEHMGEQ 434



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 57/286 (19%), Positives = 139/286 (48%), Gaps = 18/286 (6%)

Query: 773  RQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKA 832
            R  +E+L+     L ++ + +E E+S  Q  I +++ +L      L QE      E    
Sbjct: 3    RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR 62

Query: 833  ESMQRALEEQRKVTAQ--QMAMERAELERAKSALLEEQKSVMLKCG---EERRRLAAEWA 887
            E   +  E++ +V  Q  Q+  +  ++   +  + E++  V  + G   E+  ++  +  
Sbjct: 63   EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 122

Query: 888  EFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERA 947
            +   Q+   +E+  +  E+  QV  ++EG    + +++ +++ +  ++R +E Q+  +  
Sbjct: 123  QVREQEGQVREQEGQVREQEGQV-REQEG---QVREQEGQVREQEGQVREQEGQVREQEG 178

Query: 948  ALEQERQELRLEK----ERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQA 1003
             + ++  ++R ++    E+      + +   E+ E M K   E+  E E  +R+ ++   
Sbjct: 179  QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQK-QEEQMGEQEEQMRKQEEQMG 237

Query: 1004 EQQARLQ----AVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQ 1045
            EQ+ ++Q     VQ+Q+E++RKQE+ M ++   + +Q  Q+ + ++
Sbjct: 238  EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKE 283


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 131/537 (24%), Positives = 234/537 (43%), Gaps = 62/537 (11%)

Query: 523  TEPATCFPSTQKPTEPSV-PVQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAE 581
            +E AT     ++  E S+  VQ  L +  AR      E Q  LLA +  L    A L+ +
Sbjct: 896  SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKET-LTGELAGLRQQ 954

Query: 582  LLHSQARLAELEAQVRKLELERAQHELLLGSLQQQ--HQADLELIESAHRSRIKVLETSY 639
            ++ +Q + A L+ ++   +L +A+ E      +Q+  H+ DL+ ++    +  + LE   
Sbjct: 955  IIATQEK-ASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013

Query: 640  QQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRA 699
             Q + +L+RE EEL AR  ++ +E  +  A L  +    L     EK Q +  L+E ++ 
Sbjct: 1014 AQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS-LKESEKT 1072

Query: 700  SILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEA 759
            ++ +        L  + L  +R+   A S     RS       +   +S L +L ++ E 
Sbjct: 1073 ALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST------VNALTSELRDLRAQREE 1126

Query: 760  SHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLE 819
            +    +QE    +R+  EQ R L ++     R+ EE R+               Q RLLE
Sbjct: 1127 AAAAHAQE----VRRLQEQARDLGKQRDSCLREAEELRT---------------QLRLLE 1167

Query: 820  QERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEER 879
              R  +  E  +A+   R  +E R+V  Q    E  EL R+     +E+++  L+   E 
Sbjct: 1168 DARDGLRRELLEAQRKLRESQEGREVQRQ----EAGELRRSLGEGAKEREA--LRRSNEE 1221

Query: 880  RRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEE 939
             R A + AE    +++S + A  + E+ L +    E    ++ KE  EL+    E+  E 
Sbjct: 1222 LRSAVKKAE---SERISLKLANEDKEQKLAL---LEEARTAVGKEAGELRTGLQEV--ER 1273

Query: 940  KQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQ 999
             +L A R     E QELR + + +++   R+     E++    +     +E  R     +
Sbjct: 1274 SRLEARR-----ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLR 1328

Query: 1000 QVQAEQQARLQAVQQQ----QERLRKQEQHMHQEHLSL--------AQQRLQLDRAR 1044
            Q   + +A L+ ++Q+    Q +L++QE         L          ++ QLD AR
Sbjct: 1329 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 172/694 (24%), Positives = 287/694 (41%), Gaps = 83/694 (11%)

Query: 412  LRASKEEKEDWLSHALSRKKSQGLAREQHAGTSEGLHLAGTAGHPPSGSQPLTSTQGLEH 471
            L  ++  ++  L HA   +     AR + A    GL L+   G        L   +    
Sbjct: 1370 LEEARGTEKQQLDHARGLELKLEAARAEAAEL--GLRLSAAEGRAQGLEAELARVEVQRR 1427

Query: 472  AAAGGSSGTTARERPCVRPGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEPATCFPS 531
            AA     G  +  R  +  G + SP  +    S     +P  G+  G L++     C P 
Sbjct: 1428 AAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPA-RDAPAEGSGEG-LNSPSTLECSPG 1485

Query: 532  TQKP-----TEPSVPVQPLLPESLARSL------LPSTEYQKQLLAAQVQ-LQCSPAELQ 579
            +Q P     T P+ P   L PE++  +L      L S + ++  L  Q   L    AE++
Sbjct: 1486 SQPPSPGPATSPASP--DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEME 1543

Query: 580  AELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSR------IK 633
            AE   + +R  +L+  V + E  R   +  L  +Q +     E +  + R R      + 
Sbjct: 1544 AERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVA 1603

Query: 634  VLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERL 693
             LE S Q  E  LR   E++S        +A + + E     +RRL  +    +    +L
Sbjct: 1604 TLERSLQATESELRASQEKISK------MKANETKLE---GDKRRLKEVLDASESRTVKL 1654

Query: 694  RELQRASILDMRRDHEEQLQRLKL-LKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHE 752
             ELQR S+       E +LQR +L L DRE  A  +      SL   +   E  + +L  
Sbjct: 1655 -ELQRRSL-------EGELQRSRLGLSDREAQAQ-ALQDRVDSLQRQVADSEVKAGTLQL 1705

Query: 753  LSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLN 812
               R+  + L   +E E  +R   +++R L E L Q    +   R +   +   + A   
Sbjct: 1706 TVERLNGA-LAKVEESEGALR---DKVRGLTEALAQSSASLNSTRDKNLHLQKALTAC-- 1759

Query: 813  EQSRLLEQERWRVTAEQ-SKAESMQRALEEQRKVTAQQMAMERAELERAKS-ALLEEQKS 870
            E  R + QER     +  S+A     +L EQ +    ++A    EL+R ++   L++ + 
Sbjct: 1760 EHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVA--DLELQRVEAEGQLQQLRE 1817

Query: 871  VMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLI-SLAKEQAELK 929
            V+      R+R   E A  +  QKL  ER      R LQ   +R G+L  +LA+ +AE +
Sbjct: 1818 VL------RQRQEGEAAALNTVQKLQDER------RLLQ---ERLGSLQRALAQLEAEKR 1862

Query: 930  -IRASELRAEEKQLAAERAALEQERQELR---------LEKERINATALRVKLRAEEVES 979
             +  S LR E+ ++A  R   + ER++LR          EK R++ T    +L   E + 
Sbjct: 1863 EVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQR 1922

Query: 980  MSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQ 1039
              +    +    E++   AQ     QQ +L+ +QQ+ ERLR  +    +   +  +   Q
Sbjct: 1923 QIQQLEAQVVVLEQSHSPAQLEVDAQQQQLE-LQQEVERLRSAQAQTERTLEARERAHRQ 1981

Query: 1040 LDRARQDLPSSLVGLFPRAQGPAASSQSALMPPA 1073
              R  ++  S+L G   + Q     S +   PP+
Sbjct: 1982 RVRGLEEQVSTLKG---QLQQELRRSSAPFSPPS 2012



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 142/550 (25%), Positives = 232/550 (42%), Gaps = 69/550 (12%)

Query: 543  QPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELE 602
            Q  L + L       ++ Q+QL     QL     EL+     +Q ++  LE   R+ E  
Sbjct: 815  QEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEAL 874

Query: 603  RAQHELLLGSLQQQHQADLELIESAHRSRI--KVLETS---YQQREERLRRENEELSARY 657
              +H  L   L    +    L E A R R+  + LE S    Q++  +L    E+L A  
Sbjct: 875  AKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEG 934

Query: 658  LSQCQEAEQARAELTAQHQRRLAAIAQEK---DQEM--ERLRELQR---ASILDMRRDHE 709
             +     E    EL    Q+ +A   QEK   D+E+  ++L + +R   AS+ + R  HE
Sbjct: 935  QALLLAKETLTGELAGLRQQIIA--TQEKASLDKELMAQKLVQAEREAQASLREQRAAHE 992

Query: 710  EQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERE 769
            E LQRL+    RE +AA       R+      Q E+      EL +R+EA     S+E  
Sbjct: 993  EDLQRLQ----REKEAAWRELEAERAQLQSQLQREQ-----EELLARLEAEKEELSEEIA 1043

Query: 770  LGIRQRDEQLRALQERLGQQQRDMEEERSRQQE-----------VIGKMEARLNEQSRLL 818
               ++RDE L   +    Q     E E++   E           +  +ME +  +     
Sbjct: 1044 ALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQ 1103

Query: 819  EQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEE 878
            EQ+R  V A  S+   ++   EE     AQ++   R   E+A+   L +Q+   L+  EE
Sbjct: 1104 EQDRSTVNALTSELRDLRAQREEAAAAHAQEV---RRLQEQARD--LGKQRDSCLREAEE 1158

Query: 879  RR---RLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASEL 935
             R   RL  +  +   ++ L  +R  RE++   +V  Q  G                 EL
Sbjct: 1159 LRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG-----------------EL 1201

Query: 936  RAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEK-----YEE 990
            R    + A ER AL +  +ELR   ++  +  + +KL  E+ E    +  E       E 
Sbjct: 1202 RRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEA 1261

Query: 991  GE--RALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQL-DRARQDL 1047
            GE    L+E ++ + E +  LQ +++Q + L  +   + +E L+  Q RL L +RA ++ 
Sbjct: 1262 GELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRE-LAELQGRLALGERAEKES 1320

Query: 1048 PSSLVGLFPR 1057
                +GL  R
Sbjct: 1321 RRETLGLRQR 1330



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 135/572 (23%), Positives = 237/572 (41%), Gaps = 80/572 (13%)

Query: 550  LARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELL 609
            LA+ L+   E   +    +  LQ   AE+   L  ++A   ELE  + KL  E A  +  
Sbjct: 678  LAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDS 737

Query: 610  LGSLQQQHQ-------------ADLELIESAHRSRIKVLETSY------QQREERLRREN 650
            L  L   ++             A LE  +SA + R +  E         Q+R E LR E 
Sbjct: 738  LSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQ 797

Query: 651  EELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEE 710
            E          + AEQA+  L    +++L  +  E+ Q  E+L +L R          E+
Sbjct: 798  EVARQGLEGSLRVAEQAQEAL----EQQLPTLRHERSQLQEQLAQLSR-----QLSGREQ 848

Query: 711  QLQRLKLLKDREVDAATSATSHTRSLNS---------IIHQMEKFSSSLHELSSRVEASH 761
            +L++ +    R+V+A   A     +L           +  + E  + S      R+E   
Sbjct: 849  ELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEA 908

Query: 762  LTTSQ---ERELG-IRQRDEQLRALQERLGQQQRDMEEERS--RQQEVIGKMEARLNEQ- 814
            L  S    +R+L  +  R EQL A  + L   +  +  E +  RQQ +  + +A L+++ 
Sbjct: 909  LEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKEL 968

Query: 815  --SRLLEQERWRVTA--EQSKA--ESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQ 868
               +L++ ER    +  EQ  A  E +QR L+ +++   +++  ERA+L+   S L  EQ
Sbjct: 969  MAQKLVQAEREAQASLREQRAAHEEDLQR-LQREKEAAWRELEAERAQLQ---SQLQREQ 1024

Query: 869  KSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQRE--------GTLIS 920
            + ++ +   E+  L+ E A    ++      AE E ++AL +    +        GT  S
Sbjct: 1025 EELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHS 1084

Query: 921  LAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINAT-ALRVKLRAEEVES 979
            LA    E++ +  + ++ ++Q  +   AL  E ++LR ++E   A  A  V+   E+   
Sbjct: 1085 LATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARD 1144

Query: 980  MSKVASEKYEEGE-----------------RALREAQQVQAEQQARLQAVQQQQERLRKQ 1022
            + K       E E                 R L EAQ+   E Q   +  +Q+   LR+ 
Sbjct: 1145 LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRS 1204

Query: 1023 EQHMHQEHLSLAQQRLQLDRARQDLPSSLVGL 1054
                 +E  +L +   +L  A +   S  + L
Sbjct: 1205 LGEGAKEREALRRSNEELRSAVKKAESERISL 1236



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 134/582 (23%), Positives = 226/582 (38%), Gaps = 90/582 (15%)

Query: 537  EPSVPVQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQV 596
            E ++  Q LL   L   L      +K L   Q+Q     A+L A       R+ EL   V
Sbjct: 354  EAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSA-------RVTELGLAV 406

Query: 597  RKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSAR 656
            ++LE +  + + +   L ++    LE +ES        LET   +  E L++   +L+  
Sbjct: 407  KRLEKQNLEKDQVNKDLTEK----LEALESLRLQEQAALET---EDGEGLQQTLRDLAQA 459

Query: 657  YLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLK 716
             LS  +   Q    L+   +   A+    +    +R     R S     R          
Sbjct: 460  VLSDSESGVQ----LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPR------- 508

Query: 717  LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRD 776
                R    A S +S    ++S +H+ +     + ++  R EAS       R+  +   +
Sbjct: 509  ----RGPSPACSDSSTLALIHSALHKRQL---QVQDMRGRYEASQDLLGTLRKQ-LSDSE 560

Query: 777  EQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQ 836
             + RAL+E+L Q+ RD  +   +  E   +   RL   + LL +E+  +      A+   
Sbjct: 561  SERRALEEQL-QRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQA 619

Query: 837  RALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLS 896
              L ++R    +++   + EL R +  L EEQ+  +      RR L              
Sbjct: 620  EELRQER----EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRREL-------------- 661

Query: 897  KERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQEL 956
             ER+ R+ E       Q EG    LAKE  E++   S    +   L AE+A + +     
Sbjct: 662  -ERSHRQLE-------QLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALT-- 711

Query: 957  RLEKERINATALRVKLRAEEV---ESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQ 1013
            + E  R+       KLRAEE    +S+SK+++      +  L +  ++ A+ +    A+Q
Sbjct: 712  KAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL-DLNRLVAQLEEEKSALQ 770

Query: 1014 QQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSALMPPA 1073
             +Q +  ++     +E   L + RL+ + ARQ L  SL          A  +Q AL    
Sbjct: 771  GRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSL--------RVAEQAQEALEQQL 822

Query: 1074 PTTRWCSQPPTGLDPSPLHLHARLALLRHMAEQDRDFLENEQ 1115
            PT R                H R  L   +A+  R     EQ
Sbjct: 823  PTLR----------------HERSQLQEQLAQLSRQLSGREQ 848



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 104/445 (23%), Positives = 180/445 (40%), Gaps = 54/445 (12%)

Query: 635  LETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLR 694
            LET  Q  E  +  + + L AR L+Q  +     A +     R L+     + +    L 
Sbjct: 15   LETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLS-----QPESPVLLP 69

Query: 695  ELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELS 754
              + AS+L ++ +++   Q L  ++D    +           N++  ++E+        +
Sbjct: 70   ATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQ--------A 121

Query: 755  SRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDME---EERSRQQEVI------- 804
             R+E   L T + R L +RQ  E  R LQE     +R ++   E + RQ +++       
Sbjct: 122  LRLEPGELETQEPRGL-VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKI 180

Query: 805  -------GKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVT---AQQMAMER 854
                    ++E +L E+S  LEQ+R R T      ES    LEE+++ +   AQ  AM R
Sbjct: 181  LQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLR 240

Query: 855  AELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQR 914
             +L++A SA             E+ R++  +W     + +  +    RE E      +  
Sbjct: 241  EQLDQAGSA--------NQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNE 292

Query: 915  EGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRA 974
               L+ L ++    +   SE++     +  ER  L Q   EL      +    L +    
Sbjct: 293  HSRLLLLWRQVVGFRRLVSEVK-----MFTERDLL-QLGGELARTSRAVQEAGLGLSTGL 346

Query: 975  EEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLA 1034
               ES ++ A EK    +  L E  + +  ++  L A QQ Q  L K +       L LA
Sbjct: 347  RLAESRAEAALEKQALLQAQLEEQLRDKVLREKDL-AQQQMQSDLDKADLSARVTELGLA 405

Query: 1035 -----QQRLQLDRARQDLPSSLVGL 1054
                 +Q L+ D+  +DL   L  L
Sbjct: 406  VKRLEKQNLEKDQVNKDLTEKLEAL 430



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 114/527 (21%), Positives = 208/527 (39%), Gaps = 78/527 (14%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQ 618
            +Y+K+    + QL     EL+ + L       +LE+ + +LE E            QQ  
Sbjct: 182  QYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEE------------QQRS 229

Query: 619  ADLELIESAHRSRIKVLETSYQQREERLR-------RENEELSARYLSQCQEAEQARAEL 671
            A L  + +  R ++    ++ Q   E +R       R  +EL  R  +  +E E   A  
Sbjct: 230  ASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYF 289

Query: 672  TAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATS 731
            + +H R L    Q                ++  RR     +  +K+  +R  D       
Sbjct: 290  SNEHSRLLLLWRQ----------------VVGFRR----LVSEVKMFTER--DLLQLGGE 327

Query: 732  HTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLR--ALQER-LGQ 788
              R+  ++       S+ L    SR EA+     +++ L   Q +EQLR   L+E+ L Q
Sbjct: 328  LARTSRAVQEAGLGLSTGLRLAESRAEAA----LEKQALLQAQLEEQLRDKVLREKDLAQ 383

Query: 789  QQRDMEEER---SRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKV 845
            QQ   + ++   S +   +G    RL +Q+   +Q    +T +    ES++  L+EQ  +
Sbjct: 384  QQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLR--LQEQAAL 441

Query: 846  TAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWA--EFSAQQKLSKERAE-- 901
              +     +  L     A+L + +S +   G ER   A+  +    S Q+  S  R    
Sbjct: 442  ETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSP 501

Query: 902  ---REAERALQVDTQREGTLISLAKEQAELKIRASELRAE-----------EKQLA---A 944
               R   R          TL  +     + +++  ++R              KQL+   +
Sbjct: 502  GRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSES 561

Query: 945  ERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAE 1004
            ER ALE++ Q LR + +         +   + + S +++ S +      +L+ AQQ   E
Sbjct: 562  ERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEE 621

Query: 1005 QQARLQAVQQQQERLRKQEQHMHQEHLSLAQQ----RLQLDRARQDL 1047
             +   + +Q  QE LR+Q   + +E     Q     R +L+R+ + L
Sbjct: 622  LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQL 668



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 124/579 (21%), Positives = 224/579 (38%), Gaps = 105/579 (18%)

Query: 545  LLPESLARSLLPSTEYQK-----QLLAAQVQLQCSPAELQAELLHSQARLAE-------L 592
            LL ES  +  L   E +K     +L+  +  L     E++ +   +Q+R  +       L
Sbjct: 1054 LLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNAL 1113

Query: 593  EAQVRKLELER----AQHELLLGSLQQQ-----HQADLELIESAH-RSRIKVLETSYQQR 642
             +++R L  +R    A H   +  LQ+Q      Q D  L E+   R+++++LE +    
Sbjct: 1114 TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA---- 1169

Query: 643  EERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRA--- 699
             + LRRE  E + R L + QE  + + +   + +R L   A+E++       EL+ A   
Sbjct: 1170 RDGLRRELLE-AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKK 1228

Query: 700  ---SILDMRRDHEEQLQRLKLLKDREV--------------DAATSATSHTRSLNSIIHQ 742
                 + ++  +E++ Q+L LL++                 +   S     R L  +  Q
Sbjct: 1229 AESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQ 1288

Query: 743  MEKFSSS-------LHELSSRVEASHLTTSQERE--LGIRQR----DEQLRALQERLGQQ 789
            M+   S        L EL  R+        + R   LG+RQR    +  L  +++ L   
Sbjct: 1289 MKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVA 1348

Query: 790  QRDMEEE----RSRQQEVIGKMEARLNEQSRLLEQERW-----------------RVTAE 828
            QR ++E+    R+R++ ++G +E     + + L+  R                  R++A 
Sbjct: 1349 QRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAA 1408

Query: 829  QSKAESMQRAL---EEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAE 885
            + +A+ ++  L   E QR+    Q+   R+ L R          +     G   R   AE
Sbjct: 1409 EGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAE 1468

Query: 886  WA----------EFS-AQQKLSKERAEREAERALQVDTQREGT------LISLAKEQAEL 928
             +          E S   Q  S   A   A   L  +  R         L S  +E+ EL
Sbjct: 1469 GSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDEL 1528

Query: 929  KIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEKY 988
            + + S L  +  ++ AER +     ++L+            V  R   V++   +  E  
Sbjct: 1529 RTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESV 1588

Query: 989  EEGERALREAQQVQAEQQARLQAVQQQ----QERLRKQE 1023
               ER  R      A  +  LQA + +    QE++ K +
Sbjct: 1589 RRSERERRATLDQVATLERSLQATESELRASQEKISKMK 1627



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 52/166 (31%), Positives = 82/166 (49%), Gaps = 7/166 (4%)

Query: 905  ERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAE-RAALEQERQELRLEKERI 963
            E A  +  Q E  L  L +E + ++   ++ RAE  +LA +  A  E+  Q LRLE   +
Sbjct: 72   EMASLLSLQEENQL--LQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGEL 129

Query: 964  NATALRVKLRAEEVESMSKVASEK--YEEGERALREAQQVQAEQQARLQA-VQQQQERLR 1020
                 R  +R + VE   ++  E+  Y    +A +E QQ QA+   RLQ  + Q ++R  
Sbjct: 130  ETQEPRGLVR-QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCS 188

Query: 1021 KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQ 1066
            + EQ + +    L QQRL+     QDL S+L+ L    Q  A+ +Q
Sbjct: 189  ELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQ 234


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 159/704 (22%), Positives = 286/704 (40%), Gaps = 81/704 (11%)

Query: 425  HALSRKKSQGLAREQHAGTSEGLHLAGTAGHPPSGSQPLTSTQGLEHAAAGGSSGTTARE 484
            +A  +++ Q LA  +     +   LA T        Q   ++QGL H     SS    +E
Sbjct: 511  NATIQQQDQELAGLKQQAKEKQAQLAQTL------QQQEQASQGLRHQVEQLSSSLKQKE 564

Query: 485  RPCVRPGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSVPVQP 544
            +             Q+HA   L T + +R  +  +  A          +K  +  +  Q 
Sbjct: 565  QQLKEVAEKQEATRQDHAQQ-LATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQ 623

Query: 545  LLPESLARSLLPSTEYQKQLLAAQV-----QLQCSPAELQAELLHSQARLAELEAQVRK- 598
            L   + AR    ++  Q Q   A++     +LQ      + E   +QA++AELE Q+R  
Sbjct: 624  LQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE 683

Query: 599  ----LELERAQHE----------------LLLGSLQQQHQADLELIESAHR--SRIKVLE 636
                 E ER   E                +  GSL+++ +   + +E   R  S +K   
Sbjct: 684  QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET 743

Query: 637  TSYQQREERLRRENEE-------LSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQE 689
             S  ++ +R R+E EE       L AR L Q  EA QA  E+  +      A     + E
Sbjct: 744  RSLVEQHKRERKELEEERAGRKGLEAR-LQQLGEAHQAETEVLRRELAEAMAAQHTAESE 802

Query: 690  MERL-RELQ--RASILDMRRDH-------EEQLQRLKLLKDREVDAATSATSHTRSLNSI 739
             E+L +E+   R    D +++        +EQL  LK   ++       A      + S 
Sbjct: 803  CEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESH 862

Query: 740  IH-QMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDM----- 793
               Q+ +  + L EL + + A  L   QE+E+  ++  + L  LQE++    +++     
Sbjct: 863  SELQISRQQNELAELHANL-ARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921

Query: 794  ------EEERSRQQEVIGKMEARLNEQSRLLEQERWR-VTAEQSKAESMQRALEEQRKVT 846
                  E++ +  +E++ +     + Q   LE+++ R   + Q+  ++M+R  E+     
Sbjct: 922  LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGN-- 979

Query: 847  AQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFS-AQQKLSKERAEREAE 905
                     ELER ++AL+E Q     + G++ R +A    E   AQ  L+ E+A R AE
Sbjct: 980  ---------ELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR-AE 1029

Query: 906  RALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINA 965
              +++        +  A  Q  L    +E   ++++LA  R     + +EL   ++ +  
Sbjct: 1030 LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ 1089

Query: 966  TALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQH 1025
               ++  + +E  S S   SE     E    + + ++AE     Q  Q+QQE+    E+ 
Sbjct: 1090 LKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS 1149

Query: 1026 MHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSAL 1069
            +  E  S A++   L+  +  L      L   +Q   AS+Q  L
Sbjct: 1150 LEAERASRAERDSALETLQGQLEEKAQEL-GHSQSALASAQREL 1192



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 126/541 (23%), Positives = 247/541 (45%), Gaps = 79/541 (14%)

Query: 559  EYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHE-LLLGSLQQ-- 615
            + +K+L AA    +C   E + E+L  Q +L++LE  + +L+    Q +  +LG + Q  
Sbjct: 361  QLEKELSAALQDKKC--LEEKNEIL--QGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLE 416

Query: 616  ---QHQADLELIESAHRSRIKVLETSYQQREERL-------RRENEELSARY------LS 659
               Q  A L    +  ++R+++LET   Q+E +L         E ++LS+        +S
Sbjct: 417  TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSIS 476

Query: 660  QCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKL-L 718
               +A++   + +  H  RL A       E+  L     A+I    +  +++L  LK   
Sbjct: 477  NLSQAKEELEQASQAHGARLTAQVASLTSELTTLN----ATI----QQQDQELAGLKQQA 528

Query: 719  KDREVDAATSATSHTRSLNSIIHQMEKFSSSLH-------ELSSRVEASH-------LTT 764
            K+++   A +     ++   + HQ+E+ SSSL        E++ + EA+         T 
Sbjct: 529  KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588

Query: 765  SQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKM-----EARLNEQSRLLE 819
            ++ERE  +R+RD  L+ L+         +E+E++ + E++ +      EAR + Q+ + +
Sbjct: 589  AEEREASLRERDAALKQLEA--------LEKEKAAKLEILQQQLQVANEARDSAQTSVTQ 640

Query: 820  QERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVML-KCGEE 878
             +R +    + K E +Q  +E  R+   +  A + AELE    +  E+QK+    +  +E
Sbjct: 641  AQREKAELSR-KVEELQACVETARQEQHEAQA-QVAELELQLRS--EQQKATEKERVAQE 696

Query: 879  RRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAE 938
            + +L  +        K++K   E E  RA     +++  +  L  E   L  +    R E
Sbjct: 697  KDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKE 756

Query: 939  EKQLAAERAALEQERQELR---------LEKERINATALRVKLRAEEVESMSKVAS--EK 987
             ++  A R  LE   Q+L          L +E   A A +    +E  + + +VA+  E+
Sbjct: 757  LEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER 816

Query: 988  YEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSL-AQQRLQLDRARQD 1046
            YE+ +   +E  Q  A  Q +L  ++++ E+ R++ Q   ++   + +   LQ+ R + +
Sbjct: 817  YEDSQ---QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNE 873

Query: 1047 L 1047
            L
Sbjct: 874  L 874



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 149/643 (23%), Positives = 256/643 (39%), Gaps = 93/643 (14%)

Query: 493  SGSPVTQNHAASALPTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSVPVQPLLPESLAR 552
            SGS      A    PTG PK      ++S  E        QK  E +        +SL R
Sbjct: 1103 SGSGAQSEAAGRTEPTG-PKLEALRAEVSKLEQ-----QCQKQQEQA--------DSLER 1148

Query: 553  SLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLA---------------------E 591
            SL      + +  +A   LQ    E   EL HSQ+ LA                     E
Sbjct: 1149 SLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE 1208

Query: 592  LEAQVRKLELERAQHELLLGSLQQQ-----HQADLELIESAHRSRIKVLETSYQQR-EER 645
             +AQV +   E  +   L+ SL+++      Q   +  ES    R+ + E+   Q+ EER
Sbjct: 1209 WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEER 1268

Query: 646  LRRENEELSARYLSQCQEAEQARAELTA----QHQRRLAA--IAQEKDQEMERLREL-QR 698
            LR    E ++      + +   R E+ +      ++R+A+  + QE   + ER  EL Q 
Sbjct: 1269 LRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1328

Query: 699  ASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLH--ELSSR 756
                  +   +EQ      L+     A  S     + L   +   +  +   H  EL   
Sbjct: 1329 LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388

Query: 757  VEASHLTTSQ----ERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLN 812
             +A+    ++    +RELG      Q  A QER  QQ R  +   + Q  ++ K    L 
Sbjct: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA 1448

Query: 813  EQSR---------------LLEQERWRVTAEQS--KAESMQRALEEQRKV--TAQQMAME 853
            E++R                L+Q R +   E +  +A++  R  E QR+   TA+++ + 
Sbjct: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVM 1508

Query: 854  RAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQ 913
             A+ E AK  +LEE++    +  EER++L A+  +    Q+   ++ E  +++    D  
Sbjct: 1509 TAKYEGAKVKVLEERQ----RFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQ- 1563

Query: 914  REGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLR 973
                    A +  + K++A + +  E Q  A+R  L+ +  EL+ +  +    A   KL+
Sbjct: 1564 --------ASKVQQQKLKAVQAQGGESQQEAQR--LQAQLNELQAQLSQKEQAAEHYKLQ 1613

Query: 974  AEEVESMSKVASEKYEEGERALREAQQVQAEQ-----QARLQAVQQQQERLRKQEQHMHQ 1028
             E+ ++      ++ +E +  LR  +Q+Q E      +A     + QQ  L+ +E     
Sbjct: 1614 MEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTC 1673

Query: 1029 EHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSALMP 1071
             HL+   + L+   A  D     +G F  A     S +    P
Sbjct: 1674 RHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKP 1716



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 122/525 (23%), Positives = 222/525 (42%), Gaps = 61/525 (11%)

Query: 578  LQAELLHSQARLAE----LEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIK 633
            LQAE   + AR AE    L  +V+ L  E  +  +   +L+Q+  +  E  E   +  +K
Sbjct: 1272 LQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE-LK 1330

Query: 634  VLETSYQQREERLRR-----------ENEELSARYLSQCQEAEQARAELTAQHQRRLAAI 682
              +  + Q+E+ L              +E L A++L Q  +AEQA AE   +H+  L   
Sbjct: 1331 AWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE--KRHREELEQS 1388

Query: 683  AQEKDQEMERLRELQR--ASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSII 740
             Q        L   QR    ++ +R+   EQ +  + L+  +   A    S  +  + ++
Sbjct: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQL-SMLKKAHGLL 1447

Query: 741  HQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQ 800
             +  +       L  +     L   Q RE  +++        + RL + QR+ +      
Sbjct: 1448 AEENRGLGERANLGRQFLEVEL--DQAREKYVQELAAVRADAETRLAEVQREAQSTAREL 1505

Query: 801  QEVIGKMEA---RLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAEL 857
            + +  K E    ++ E+ +  ++ER ++TA+  + E  QR   +Q     ++++ + A+ 
Sbjct: 1506 EVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQ----VEELSKKLADS 1561

Query: 858  ERAKSALLEEQKSVMLKCGE---ERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQR 914
            ++A     ++ K+V  + GE   E +RL A+  E  AQ    ++ AE    +  +  T  
Sbjct: 1562 DQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHY 1621

Query: 915  EGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRA 974
            +      AK+Q   +++  +LR+ E+        L++E +ELR E ER+     +  L+ 
Sbjct: 1622 D------AKKQQNQELQ-EQLRSLEQ--------LQKENKELRAEAERLGHELQQAGLKT 1666

Query: 975  EEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLA 1034
            +E E   +  + +     R+L EAQ   A+QQ R     Q      K  +   +  L L+
Sbjct: 1667 KEAEQTCRHLTAQV----RSL-EAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLS 1721

Query: 1035 QQRLQLDRARQDLPSSLVGLFPRAQ-------GPAASSQSALMPP 1072
               L L    +  P S+    PR Q       G  AS  S  +PP
Sbjct: 1722 IDSLDLS-CEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPP 1765



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 123/530 (23%), Positives = 227/530 (42%), Gaps = 47/530 (8%)

Query: 547  PESLARSLLPSTEYQKQLLAAQVQLQCSPA-ELQAELLHSQARLAELEAQVRKLELERAQ 605
            P S    +L + ++Q + L  Q+  + S   EL+ EL  ++  L E +AQ+  ++ +R  
Sbjct: 201  PASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQ-QRID 259

Query: 606  HELLLGSLQQQ---HQADLELIESAHRSRIKVLETSYQQREE-------------RLRRE 649
               LL   Q        +LE +   + S    L  + +Q ++             +L  E
Sbjct: 260  RLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEE 319

Query: 650  NEELSAR---YLSQCQEAEQARAELTAQHQRRLAAIAQEKDQ-EMERLRELQRASILDMR 705
            N +LS +   + S  Q+ + A  ELT +H +      +++ Q E E    LQ    L+ +
Sbjct: 320  NGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEK 379

Query: 706  RDHEE----QLQR-LKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEAS 760
             +  +    QL+  L  L+D               L ++  +    +++  +L +RVE  
Sbjct: 380  NEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEML 439

Query: 761  HLTTSQERELGIRQRD------EQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQ 814
                 Q+    + +R       +QL +L   L     ++ + +   ++      ARL  Q
Sbjct: 440  ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499

Query: 815  SRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLE--EQKSVM 872
               L  E   + A   + +     L++Q K    Q+A    + E+A   L    EQ S  
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559

Query: 873  LKCGEERRRLAAEWAEFSAQ---QKLSKERAEREAERALQVDTQREGTLISLAKEQA-EL 928
            LK  E++ +  AE  E + Q   Q+L+    EREA  +L+        L +L KE+A +L
Sbjct: 560  LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREA--SLRERDAALKQLEALEKEKAAKL 617

Query: 929  KIRASELR-AEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKVASEK 987
            +I   +L+ A E + +A+ +  + +R++  L ++     A     R E+ E+ ++VA   
Sbjct: 618  EILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVA--- 674

Query: 988  YEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQR 1037
              E E  LR  QQ   E++   Q   Q QE+L+  ++ +     SL +++
Sbjct: 675  --ELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEK 722


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 119/505 (23%), Positives = 239/505 (47%), Gaps = 66/505 (13%)

Query: 548  ESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELE-AQV----RKLELE 602
            E+L   L   ++++ +L      LQ    ELQ   L    R++ELE  QV     KLELE
Sbjct: 1682 ENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELE 1741

Query: 603  RAQHELLLGSLQQQHQADLE----LIESAHR--SRIKVLETSYQQREERLRRENEELSAR 656
              Q       + QQ + ++E    L+E   R   R+     + Q   E L +E E+L   
Sbjct: 1742 NLQ------QISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDL--- 1792

Query: 657  YLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEE--QLQR 714
                 QE      +  AQ +R LAA  +    E   L +L+    L++R+  +E  QL R
Sbjct: 1793 -----QEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLE----LNVRKLQQELDQLNR 1843

Query: 715  LKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQ 774
             KL    ++ A        R     ++ +++  +++ +  +  +   L T++ +++ + +
Sbjct: 1844 DKLSLHNDISAMQQQLQEKR---EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900

Query: 775  RDEQLRALQERLGQQQRDMEEERSRQQEV------IGKMEARLNEQSRLLEQERWRVTAE 828
            +    + + E   + +   +EE ++QQ++      I + + +L +Q  + ++ +    +E
Sbjct: 1901 QTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE 1960

Query: 829  QSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAE 888
            +SK E+ +  L+EQ+    +++  ++++L++  S +L  ++ V     EER      W E
Sbjct: 1961 ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER------WCE 2014

Query: 889  FSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAE--------EK 940
             S ++ LS+ + +  +ER  Q+  ++ G L++L KE   ++   S LR +        EK
Sbjct: 2015 -SLEKTLSQTKRQL-SEREQQL-VEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEK 2071

Query: 941  QLAAERAALEQERQELR---LEKERINATALRVKLRAEEVESMSKVASEKYEEGERALRE 997
            Q+A+ + AL+ +R +L    LE+++ N+         +E+ ++  VA + +E   R ++E
Sbjct: 2072 QVASLKEALKIQRSQLEKNLLEQKQENSCI------QKEMATIELVAQDNHERARRLMKE 2125

Query: 998  AQQVQAEQQARLQAVQQQQERLRKQ 1022
              Q+Q E     + +  Q++  R+Q
Sbjct: 2126 LNQMQYEYTELKKQMANQKDLERRQ 2150



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 145/696 (20%), Positives = 277/696 (39%), Gaps = 113/696 (16%)

Query: 494  GSPVTQNHAASALPTGSPK--RGTAPGDLSATEPATCFPSTQKPTEPSVPVQPLLPESLA 551
            GSPV Q  A  A P   P   R   PG +    P    P    P  P+  + P +P  + 
Sbjct: 1253 GSPVPQGMALYAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSI-PFIPMGVL 1311

Query: 552  RSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAE---LEAQVRKLELERAQ-HE 607
               +P              L+   + L+  + H +++  E   + A  R+ E E  + H 
Sbjct: 1312 HCNVPEHH----------NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHH 1361

Query: 608  LLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQA 667
             +   LQ++   + E +E  HR+  K      QQ+++ +    E L            + 
Sbjct: 1362 NIDDLLQEKKSLECE-VEELHRTVQK-----RQQQKDFIDGNVESLMT----------EL 1405

Query: 668  RAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAAT 727
              E + +H   +     ++ + +E+    +R+ + +  R   E    L   K++  +A  
Sbjct: 1406 EIEKSLKHHEDIV----DEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVE 1461

Query: 728  SATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLG 787
              T   RSL           S   EL  R        +QE  + + + D+QLR+LQ    
Sbjct: 1462 KFTDAKRSLLQT-------ESDAEELERR--------AQETAVNLVKADQQLRSLQA--- 1503

Query: 788  QQQRDMEEERSRQQEV---IGKMEARLNEQSRLLEQERWRVTAE----QSKAESMQRALE 840
               +D+E+ + +Q+E+   I K+ A  +   + L +++ ++T E    Q   E  +R  +
Sbjct: 1504 -DAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED 1562

Query: 841  EQRKVTAQQMAM---ERAELERAKSALLEEQKSVML---KCGEERRRL-----AAEWAEF 889
               +V  +   +   +RAELE+ KS +  +Q+ + +   + G ++  L     +   A+ 
Sbjct: 1563 HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA 1622

Query: 890  SAQQKLSKERAE--------REAERALQVDTQREGTL-ISLAKEQAELKIRASELRAEE- 939
              Q+ L     E        RE +  L+  + ++G L + +++ + +L +   E+  EE 
Sbjct: 1623 DLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEE 1682

Query: 940  ------KQLAAERAALEQERQELRLEKERINATALRVKLRAEEVE-SMSKVASEKYEEGE 992
                  +Q++  +  L+     L+LE   +    L+   R  E+E +   V  EK E   
Sbjct: 1683 NLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLE--- 1739

Query: 993  RALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLP---- 1048
              L   QQ+  +Q+  ++  +Q  ER +++ + M  E  +L      L + ++DL     
Sbjct: 1740 --LENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD 1797

Query: 1049 ------SSLVGLFPRAQGPAASSQSALMPPAPTTRWCSQPPTGLDPSPLHLHARLALLRH 1102
                  +    +   A+  +   QS L       R   Q    L+   L LH  ++ ++ 
Sbjct: 1798 IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQ 1857

Query: 1103 MAEQDRDF-------LENEQFFLETLKKGSYNLTSH 1131
              ++ R+        L N Q  L   K+   + T H
Sbjct: 1858 QLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKH 1893



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 134/600 (22%), Positives = 241/600 (40%), Gaps = 122/600 (20%)

Query: 564  LLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHEL-LLGSLQQQHQADL- 621
            L  ++V LQ   AEL  E L SQ    + E  V   +L   + EL LL     Q +ADL 
Sbjct: 1568 LKESEVLLQAKRAEL--EKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQ 1625

Query: 622  --------ELIESA-HRSRIKVL--ETSYQQRE----------------ERLRRENEELS 654
                    E+ E   H   +K L  E S+Q+ E                + + +E E L 
Sbjct: 1626 EALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQ 1685

Query: 655  A-------------RYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASI 701
                            L   Q        L  QH +R++ + + +   +E   EL+    
Sbjct: 1686 VVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQ 1745

Query: 702  LDMRRDHEEQLQRLKLLKD-REVDAATSATSHTRSLNSIIHQMEKFSSSLHE-------- 752
            +  ++  E + Q+  L +D RE++     T+ +R+L S +  + K    L E        
Sbjct: 1746 ISQQQKGEIEWQKQLLERDKREIE---RMTAESRALQSCVECLSKEKEDLQEKCDIWEKK 1802

Query: 753  --LSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRD----------MEEERSRQ 800
               + RV A+    S+  +  + + +  +R LQ+ L Q  RD          M+++   +
Sbjct: 1803 LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEK 1862

Query: 801  QEVIGKMEAR-------------------------LNEQSRL----------LEQERWRV 825
            +E +  ++                           L+EQ+RL           E  +   
Sbjct: 1863 REAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEE 1922

Query: 826  TAEQSKAESMQRALEEQR-KVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAA 884
              +Q + + +Q  +EE + K+  Q+M  +R + ER       E   V LK  E++ +L  
Sbjct: 1923 ETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLK--EQQHQLEK 1980

Query: 885  EWAEFSAQ--QKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQL 942
            E  +  ++  Q LSK  A  E  R LQ   + E    SL K  ++ K + SE   +  + 
Sbjct: 1981 ELTDQKSKLDQVLSKVLAAEERVRTLQ---EEERWCESLEKTLSQTKRQLSEREQQLVEK 2037

Query: 943  AAERAALEQERQELRLEKERINATALRVKLRAE-EVESMSKVASEKYEEGERALREAQQV 1001
            + E  AL++E   +R +   +    L  + +AE +V S+ +    +  + E+ L E +Q 
Sbjct: 2038 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQE 2097

Query: 1002 QA---EQQARLQAVQQ----QQERLRKQEQHMHQEHLSLAQQ---RLQLDRARQDLPSSL 1051
             +   ++ A ++ V Q    +  RL K+   M  E+  L +Q   +  L+R + ++  ++
Sbjct: 2098 NSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAM 2157



 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 91/447 (20%), Positives = 180/447 (40%), Gaps = 39/447 (8%)

Query: 565  LAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELI 624
            L A++ L+ + A    E L    RL +LE    + ELE+ +  L     + Q   + E  
Sbjct: 708  LEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQE 767

Query: 625  ESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQ 684
             S   +++K L+      +++L+     L+   +      E+  A +  + +R+L     
Sbjct: 768  NSELHAKLKHLQDDNNLLKQQLKDFQNHLN-HVVDGLVRPEEVAARVD-ELRRKLKLGTG 825

Query: 685  EKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQME 744
            E    +    ++   S+ D+++   E L R K  +D       +     +    +  Q E
Sbjct: 826  E--MNIHSPSDVLGKSLADLQKQFSEILARSKWERDE------AQVRERKLQEEMALQQE 877

Query: 745  KFSSSLHEL----SSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQ 800
            K ++   E        +EA      ++ E  I+Q + ++  LQE L   +        + 
Sbjct: 878  KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQL 937

Query: 801  QEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERA 860
            QE   + E  L +   L ++++      Q +   + + L++ +K  A    +  AEL  A
Sbjct: 938  QEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIA 997

Query: 861  KSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLIS 920
            K  L     +VM K  +ER           A++    ER  R+A +A +           
Sbjct: 998  KDQLKSLHGTVM-KINQER-----------AEELQEAERFSRKAAQAAR----------D 1035

Query: 921  LAKEQAELKIRASELR--AEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVE 978
            L + +AE+++  + LR   E+ +L  E+  +        LE E++N T  R +     ++
Sbjct: 1036 LTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQ 1095

Query: 979  SMSKVASEKYEEG-ERALREAQQVQAE 1004
            ++  +     + G E  L E  +++ E
Sbjct: 1096 NVLDLTGSDNKGGFENVLEEIAELRRE 1122



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 70/301 (23%), Positives = 127/301 (42%), Gaps = 27/301 (8%)

Query: 574  SPAELQAE----LLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHR 629
            S A+LQ +    L  S+    E + + RKL+ E A  +  L + Q++ +   +  E A  
Sbjct: 839  SLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFR---QACERALE 895

Query: 630  SRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQE 689
            +R+     ++ +R+   R +  E    YL   QE  ++  E+      +L    +EK++ 
Sbjct: 896  ARM-----NFDKRQHEARIQQMENEIHYL---QENLKSMEEIQGLTDLQLQEADEEKERI 947

Query: 690  MERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSS 749
            + +LREL++   L+  +  E+     K LK  +   ATS    T  L     Q++    S
Sbjct: 948  LAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLK----S 1003

Query: 750  LHELSSRVEASHLTTSQERELGIRQRDEQLRAL---QERLGQQQRDMEEERSRQQEVIGK 806
            LH    ++        QE E   R+  +  R L   +  +   Q  + ++  + +  + K
Sbjct: 1004 LHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEK 1063

Query: 807  MEARLNEQSRLLEQERWRVTAEQSKAE--SMQRALE---EQRKVTAQQMAMERAELERAK 861
                    S++LE E+   T E+ + E   +Q  L+      K   + +  E AEL R  
Sbjct: 1064 TGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREV 1123

Query: 862  S 862
            S
Sbjct: 1124 S 1124



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 88/429 (20%), Positives = 158/429 (36%), Gaps = 82/429 (19%)

Query: 552  RSLLPSTEYQKQLLAAQVQLQ------------CSPAE---------LQAELLHSQARLA 590
            + LL +T++Q  LL+ Q +LQ            C   E         LQ E+  ++ +L 
Sbjct: 1885 QDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLV 1944

Query: 591  ELEAQVRKLELERAQHELLLGSL-----QQQHQADLELIESAHRSRIKVLETSYQQREER 645
            + E   ++L+ ER   E  L +      +QQHQ + EL +   +S++  + +     EER
Sbjct: 1945 QQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQ--KSKLDQVLSKVLAAEER 2002

Query: 646  LRRENEELS-----ARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRAS 700
            +R   EE        + LSQ +     R +   +    L A+ +E D  M     L R  
Sbjct: 2003 VRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADS-MRADFSLLRNQ 2061

Query: 701  ILDMRRDHEEQLQRLK-------------LLKDREVDAATSATSHT------------RS 735
             L  R+  E+Q+  LK             LL+ ++ ++       T            R 
Sbjct: 2062 FLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARR 2121

Query: 736  LNSIIHQME---------------------KFSSSLHELSSRVEASHLTTSQERELGIRQ 774
            L   ++QM+                     + S ++  L S V+    T+ +     + +
Sbjct: 2122 LMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPE 2181

Query: 775  RDEQLRALQERLGQQQRDMEEERSRQQEVI--GKMEARLNEQSRLLEQERWRVTAEQSKA 832
                L A+ ER    + ++E  +      +  G  E +LN     +  E WR  A + K 
Sbjct: 2182 LPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKL 2241

Query: 833  ESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQ 892
               +  L+ Q +    + A    + +R     L   +  +   GE     +A+ A   + 
Sbjct: 2242 RHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301

Query: 893  QKLSKERAE 901
             +L     E
Sbjct: 2302 SQLESSLTE 2310



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 94/439 (21%), Positives = 181/439 (41%), Gaps = 74/439 (16%)

Query: 623  LIESAHRSRIKVLETSYQQREERLR-RENEELSARYLSQCQEAEQARAELTAQHQRRLAA 681
            +I+SA   +IK +E   Q R + +  R +  L  +   + ++   A+  L+  H      
Sbjct: 404  IIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDE---- 459

Query: 682  IAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIH 741
            I + + Q +    E ++          EE +Q LK + +   D         + L+  + 
Sbjct: 460  IEKAEQQILRATEEFKQL---------EEAIQ-LKKISEAGKDLLY------KQLSGRLQ 503

Query: 742  QMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQ 801
             + K      +L  ++E       Q++E+  +Q++  ++ LQ  +        +    + 
Sbjct: 504  LVNKLRQEALDLELQME------KQKQEIAGKQKE--IKDLQIAIDSLDSKDPKHSHMKA 555

Query: 802  EVIGKMEAR--LNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERA---E 856
            +  GK +    +N+Q + LE     + +  +K     + LEEQ  +T  Q+A   A   +
Sbjct: 556  QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQ--LTEGQIAANEALKKD 613

Query: 857  LERAKSALLEEQ---KSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQ 913
            LE   S L E     K    +   E R+L  E  + +  Q+L++   ER+    + +D +
Sbjct: 614  LEGVISGLQEYLGTIKGQATQAQNECRKLRDE--KETLLQRLTEVEQERDQLEIVAMDAE 671

Query: 914  REGTLISLAKEQAEL--------KIRAS------ELRAEEKQLAAERAALEQERQELRLE 959
                  ++ KE AEL        ++ AS      +L A E +L A     + E  +L+ E
Sbjct: 672  ------NMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEE 725

Query: 960  KERI------NATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQ 1013
             E++        +AL+ +L  E     + +   ++ E      E +Q  +E  A+L+ + 
Sbjct: 726  LEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE------EKEQENSELHAKLKHL- 778

Query: 1014 QQQERLRKQEQHMHQEHLS 1032
            Q    L KQ+    Q HL+
Sbjct: 779  QDDNNLLKQQLKDFQNHLN 797



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 75/402 (18%), Positives = 160/402 (39%), Gaps = 45/402 (11%)

Query: 694  RELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHEL 753
            ++L+   +L+++ +    LQ +  LK   +    S       + ++ H ++     L  L
Sbjct: 190  KKLKSLRVLNLKGNKISSLQDISKLKP--LQDLISLILVENPVVTLPHYLQFTIFHLRSL 247

Query: 754  SSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQ---------QEVI 804
             S +E   +TT   +E   R   E++  L+  L ++  + EE +S+Q         Q+ +
Sbjct: 248  ES-LEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKL 306

Query: 805  GK---------------MEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQ---RKVT 846
             K               +++ LN ++ LL+Q+    T E ++A   Q  LE++    K+ 
Sbjct: 307  NKSLKEEAMLQKQSCEELKSDLNTKNELLKQK----TIELTRACQKQYELEQELAFYKID 362

Query: 847  AQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAER 906
            A+   +     E A+     ++   + K   +R   A E     + Q +  ++ E + + 
Sbjct: 363  AKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQL 422

Query: 907  A---------LQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELR 957
                        +DTQ E     ++  Q  L     E+   E+Q+       +Q  + ++
Sbjct: 423  RNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ 482

Query: 958  LEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQ--ARLQAVQQQ 1015
            L+K       L  K  +  ++ ++K+  E  +   +  ++ Q++  +Q+    LQ     
Sbjct: 483  LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS 542

Query: 1016 QERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPR 1057
             +    +  HM  +     QQ   +++  Q L S L  +  R
Sbjct: 543  LDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSR 584


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.124    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,020,829
Number of Sequences: 37866
Number of extensions: 2531398
Number of successful extensions: 39992
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 558
Number of HSP's successfully gapped in prelim test: 1998
Number of HSP's that attempted gapping in prelim test: 15724
Number of HSP's gapped (non-prelim): 12058
length of query: 1133
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1020
effective length of database: 13,968,660
effective search space: 14248033200
effective search space used: 14248033200
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.