Search of human proteins with 122937263

Search of human proteins with 122937263

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937263 fat mass and obesity associated [Homo sapiens]
         (505 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937263 fat mass and obesity associated [Homo sapiens]          1050   0.0  
gi|4827046 U2 small nuclear RNA auxiliary factor 1-like 2 [Homo ...    33   0.47 
gi|83700235 eukaryotic translation initiation factor 4A2 [Homo s...    33   0.47 
gi|197927452 dynein, axonemal, heavy chain 1 [Homo sapiens]            33   0.47 
gi|224451107 AlkB homolog 2 [Homo sapiens]                             31   2.3  
gi|48717226 AlkB homolog 2 [Homo sapiens]                              31   2.3  
gi|224451103 AlkB homolog 2 [Homo sapiens]                             31   2.3  
gi|30578410 source of immunodominant MHC-associated peptides [Ho...    31   3.0  
gi|149944548 neurobeachin-like 2 [Homo sapiens]                        30   5.1  
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]      30   6.7  
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]      30   6.7  
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]      30   6.7  
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]       30   6.7  
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso...    30   6.7  
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso...    30   6.7  

>gi|122937263 fat mass and obesity associated [Homo sapiens]
          Length = 505

 Score = 1050 bits (2714), Expect = 0.0
 Identities = 505/505 (100%), Positives = 505/505 (100%)

Query: 1   MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE 60
           MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
Sbjct: 1   MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE 60

Query: 61  LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV 120
           LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
Sbjct: 61  LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV 120

Query: 121 KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG 180
           KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
Sbjct: 121 KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG 180

Query: 181 MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS 240
           MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
Sbjct: 181 MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS 240

Query: 241 AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD 300
           AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
Sbjct: 241 AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD 300

Query: 301 LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE 360
           LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
Sbjct: 301 LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE 360

Query: 361 PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE 420
           PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
Sbjct: 361 PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE 420

Query: 421 VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD 480
           VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
Sbjct: 421 VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD 480

Query: 481 ASMPLPFDLTDIVSELRGQLLEAKP 505
           ASMPLPFDLTDIVSELRGQLLEAKP
Sbjct: 481 ASMPLPFDLTDIVSELRGQLLEAKP 505


>gi|4827046 U2 small nuclear RNA auxiliary factor 1-like 2 [Homo
          sapiens]
          Length = 482

 Score = 33.5 bits (75), Expect = 0.47
 Identities = 20/67 (29%), Positives = 35/67 (52%)

Query: 2  KRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEEL 61
          K+   A ++E+  K+ + L  L D+ L     ++D F ++ QL+  KL+ RE   + EE 
Sbjct: 16 KKYRAALKKEKRKKRRQELARLRDSGLSQKEEEEDTFIEEQQLEEEKLLERERQRLHEEW 75

Query: 62 HKEVQEA 68
              Q+A
Sbjct: 76 LLREQKA 82


>gi|83700235 eukaryotic translation initiation factor 4A2 [Homo
           sapiens]
          Length = 407

 Score = 33.5 bits (75), Expect = 0.47
 Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 12/107 (11%)

Query: 58  SEELHKEVQEAFLTLHK------HGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNT 111
           + EL +++Q+  L L        H C+    VR + + L      I++G PG  +  LN 
Sbjct: 110 TRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNR 169

Query: 112 RLFTVPWPVKGSNIKHTEAEIAAA-----CETFLKLNDYLQIETIQA 153
           R  +  W +K   +   +  ++        E F KLN  +Q+  + A
Sbjct: 170 RYLSPKW-IKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSA 215


>gi|197927452 dynein, axonemal, heavy chain 1 [Homo sapiens]
          Length = 4265

 Score = 33.5 bits (75), Expect = 0.47
 Identities = 35/121 (28%), Positives = 53/121 (43%), Gaps = 18/121 (14%)

Query: 58   SEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDL--------LTPVSRILIG--NPGCTYK 107
            +E+L K V EAF T+HK    F+D+   Q   L          P   ++ G  NPG   +
Sbjct: 1050 AEQLEKNVVEAFKTMHKCVKQFKDMPACQEVALDIRARIEEFKPYIPLIQGLRNPGMRIR 1109

Query: 108  YLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDA 167
            +  T    +       N++       A C   L++N    IE+I  + E+A KE A E A
Sbjct: 1110 HWETLSNQI-----NINVRPKANLTFARC---LEMNLQDHIESISKVAEVAGKEYAIEQA 1161

Query: 168  V 168
            +
Sbjct: 1162 L 1162


>gi|224451107 AlkB homolog 2 [Homo sapiens]
          Length = 261

 Score = 31.2 bits (69), Expect = 2.3
 Identities = 25/93 (26%), Positives = 39/93 (41%), Gaps = 8/93 (8%)

Query: 53  EASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTR 112
           EA  + +EL KEV+      +  G L R  V++ GK    P  +   G+ G TY +    
Sbjct: 77  EADEIFQELEKEVE------YFTGALAR--VQVFGKWHSVPRKQATYGDAGLTYTFSGLT 128

Query: 113 LFTVPWPVKGSNIKHTEAEIAAACETFLKLNDY 145
           L   PW      I+   + +      F+ +N Y
Sbjct: 129 LSPKPWIPVLERIRDHVSGVTGQTFNFVLINRY 161


>gi|48717226 AlkB homolog 2 [Homo sapiens]
          Length = 261

 Score = 31.2 bits (69), Expect = 2.3
 Identities = 25/93 (26%), Positives = 39/93 (41%), Gaps = 8/93 (8%)

Query: 53  EASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTR 112
           EA  + +EL KEV+      +  G L R  V++ GK    P  +   G+ G TY +    
Sbjct: 77  EADEIFQELEKEVE------YFTGALAR--VQVFGKWHSVPRKQATYGDAGLTYTFSGLT 128

Query: 113 LFTVPWPVKGSNIKHTEAEIAAACETFLKLNDY 145
           L   PW      I+   + +      F+ +N Y
Sbjct: 129 LSPKPWIPVLERIRDHVSGVTGQTFNFVLINRY 161


>gi|224451103 AlkB homolog 2 [Homo sapiens]
          Length = 261

 Score = 31.2 bits (69), Expect = 2.3
 Identities = 25/93 (26%), Positives = 39/93 (41%), Gaps = 8/93 (8%)

Query: 53  EASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTR 112
           EA  + +EL KEV+      +  G L R  V++ GK    P  +   G+ G TY +    
Sbjct: 77  EADEIFQELEKEVE------YFTGALAR--VQVFGKWHSVPRKQATYGDAGLTYTFSGLT 128

Query: 113 LFTVPWPVKGSNIKHTEAEIAAACETFLKLNDY 145
           L   PW      I+   + +      F+ +N Y
Sbjct: 129 LSPKPWIPVLERIRDHVSGVTGQTFNFVLINRY 161


>gi|30578410 source of immunodominant MHC-associated peptides [Homo
           sapiens]
          Length = 826

 Score = 30.8 bits (68), Expect = 3.0
 Identities = 17/54 (31%), Positives = 22/54 (40%)

Query: 26  TWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLF 79
           T+  Y+ P    FY  W   Y K+ +   +SVSE         F  LH   C F
Sbjct: 372 TYTGYIAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTTWVSFFFDLHILVCTF 425


>gi|149944548 neurobeachin-like 2 [Homo sapiens]
          Length = 2754

 Score = 30.0 bits (66), Expect = 5.1
 Identities = 41/183 (22%), Positives = 69/183 (37%), Gaps = 34/183 (18%)

Query: 21  EELEDTWLPYLTPKDDEFYQQWQLKY-------------------------PKLILREAS 55
           E L + WL Y   KD  + QQW   +                         P L L E  
Sbjct: 5   ERLYELWLLYYAQKDLGYLQQWLKAFVGAFKKSISLSSLEPRRPEEAGAEVPLLPLDELH 64

Query: 56  SVSEELHK-EVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLF 114
            ++E+LH+ ++++A L L     L R+L  I+       V R+L          L   L 
Sbjct: 65  VLAEQLHQADLEQALLLLKLFIILCRNLENIEAGRGQVLVPRVL-----ALLTKLVAELK 119

Query: 115 TVPWPV-KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMS 173
             P P  +G+ +++        CE     + Y      ++ E +++KEK+     P  + 
Sbjct: 120 GCPPPQGRGTQLENVALHALLLCEGL--FDPYQTWRRQRSGEVISSKEKSKYKFPPAALP 177

Query: 174 ADF 176
            +F
Sbjct: 178 QEF 180


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score = 29.6 bits (65), Expect = 6.7
 Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 2/57 (3%)

Query: 211 KMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDP 267
           K P+++++P     ++ +  H D +   R       Y   G EE  EDDSH E  +P
Sbjct: 285 KFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEE--EDDSHGEEGEP 339


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score = 29.6 bits (65), Expect = 6.7
 Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 2/57 (3%)

Query: 211 KMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDP 267
           K P+++++P     ++ +  H D +   R       Y   G EE  EDDSH E  +P
Sbjct: 285 KFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEE--EDDSHGEEGEP 339


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 29.6 bits (65), Expect = 6.7
 Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 2/57 (3%)

Query: 211 KMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDP 267
           K P+++++P     ++ +  H D +   R       Y   G EE  EDDSH E  +P
Sbjct: 285 KFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEE--EDDSHGEEGEP 339


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score = 29.6 bits (65), Expect = 6.7
 Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 2/57 (3%)

Query: 211 KMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDP 267
           K P+++++P     ++ +  H D +   R       Y   G EE  EDDSH E  +P
Sbjct: 285 KFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEE--EDDSHGEEGEP 339


>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
            a [Homo sapiens]
          Length = 1608

 Score = 29.6 bits (65), Expect = 6.7
 Identities = 18/49 (36%), Positives = 28/49 (57%), Gaps = 4/49 (8%)

Query: 63   KEVQEAFLTLHKHGCLFRDLVRIQGKDL-LTPVSRILIGNPGCTYKYLN 110
            K++  A   LH+HG + RD   I+G ++ LT    I +G+ GC+ K  N
Sbjct: 1445 KQITIAINVLHEHGIVHRD---IKGANIFLTSSGLIKLGDFGCSVKLKN 1490


>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
            b [Homo sapiens]
          Length = 1558

 Score = 29.6 bits (65), Expect = 6.7
 Identities = 18/49 (36%), Positives = 28/49 (57%), Gaps = 4/49 (8%)

Query: 63   KEVQEAFLTLHKHGCLFRDLVRIQGKDL-LTPVSRILIGNPGCTYKYLN 110
            K++  A   LH+HG + RD   I+G ++ LT    I +G+ GC+ K  N
Sbjct: 1395 KQITIAINVLHEHGIVHRD---IKGANIFLTSSGLIKLGDFGCSVKLKN 1440


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,592,368
Number of Sequences: 37866
Number of extensions: 955013
Number of successful extensions: 2500
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2497
Number of HSP's gapped (non-prelim): 15
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.