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Search of human proteins with 27477115
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
(1624 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 3240 0.0
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 2253 0.0
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 1928 0.0
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 1861 0.0
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 1219 0.0
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 1219 0.0
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 342 1e-93
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 296 1e-79
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 296 1e-79
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 287 5e-77
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 280 6e-75
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 268 2e-71
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 268 2e-71
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 261 5e-69
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 259 1e-68
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens] 124 1e-27
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens] 124 1e-27
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens] 124 1e-27
gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s... 92 4e-18
gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap... 87 2e-16
gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap... 83 2e-15
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 82 3e-15
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 79 4e-14
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 79 4e-14
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 79 4e-14
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 79 4e-14
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 79 4e-14
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 79 4e-14
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 75 5e-13
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 75 7e-13
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 3240 bits (8400), Expect = 0.0
Identities = 1624/1624 (100%), Positives = 1624/1624 (100%)
Query: 1 MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQM 60
MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQM
Sbjct: 1 MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQM 60
Query: 61 SSMDLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLN 120
SSMDLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLN
Sbjct: 61 SSMDLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLN 120
Query: 121 YSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA 180
YSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA
Sbjct: 121 YSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA 180
Query: 181 FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYY 240
FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYY
Sbjct: 181 FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYY 240
Query: 241 VSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGF 300
VSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGF
Sbjct: 241 VSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGF 300
Query: 301 VMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW 360
VMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW
Sbjct: 301 VMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW 360
Query: 361 TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYF 420
TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYF
Sbjct: 361 TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYF 420
Query: 421 DKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEA 480
DKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEA
Sbjct: 421 DKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEA 480
Query: 481 IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS 540
IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS
Sbjct: 481 IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS 540
Query: 541 VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQR 600
VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQR
Sbjct: 541 VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQR 600
Query: 601 VVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLL 660
VVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLL
Sbjct: 601 VVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLL 660
Query: 661 KEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER 720
KEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER
Sbjct: 661 KEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER 720
Query: 721 CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVS 780
CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVS
Sbjct: 721 CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVS 780
Query: 781 ITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVA 840
ITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVA
Sbjct: 781 ITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVA 840
Query: 841 LWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT 900
LWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT
Sbjct: 841 LWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT 900
Query: 901 YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAI 960
YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAI
Sbjct: 901 YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAI 960
Query: 961 IVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEY 1020
IVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEY
Sbjct: 961 IVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEY 1020
Query: 1021 GYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL 1080
GYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL
Sbjct: 1021 GYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL 1080
Query: 1081 ILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWS 1140
ILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWS
Sbjct: 1081 ILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWS 1140
Query: 1141 FFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPDSMDYLGASESE 1200
FFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPDSMDYLGASESE
Sbjct: 1141 FFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPDSMDYLGASESE 1200
Query: 1201 IVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGEEED 1260
IVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGEEED
Sbjct: 1201 IVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGEEED 1260
Query: 1261 IQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGE 1320
IQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGE
Sbjct: 1261 IQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGE 1320
Query: 1321 VIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQENALWPNLTVR 1380
VIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQENALWPNLTVR
Sbjct: 1321 VIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQENALWPNLTVR 1380
Query: 1381 QHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPS 1440
QHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPS
Sbjct: 1381 QHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPS 1440
Query: 1441 VVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLR 1500
VVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLR
Sbjct: 1441 VVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLR 1500
Query: 1501 CIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLPVED 1560
CIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLPVED
Sbjct: 1501 CIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLPVED 1560
Query: 1561 VRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDLEEDFDPSVKWKLLL 1620
VRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDLEEDFDPSVKWKLLL
Sbjct: 1561 VRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDLEEDFDPSVKWKLLL 1620
Query: 1621 QEEP 1624
QEEP
Sbjct: 1621 QEEP 1624
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 2253 bits (5837), Expect = 0.0
Identities = 1134/1627 (69%), Positives = 1324/1627 (81%), Gaps = 49/1627 (3%)
Query: 1 MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQM 60
M KR++SV QQTWALLCKN LKKWRMKR++L+EWL S LL+L LY++ + HQV+D +
Sbjct: 1 MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIY-PHSHQVNDFSSL 59
Query: 61 SSMDLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLN 120
+MDLGRVD+FN++ + + + P + TTQ+IMNKVAS PFL G+ ++G PDE+S+ E N
Sbjct: 60 LTMDLGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTAN 119
Query: 121 YSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA 180
Y + VRV FT+T+SYHLKF GH +P KEH+DH+AHC NE + CE S FW++GFVA
Sbjct: 120 YPEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVA 179
Query: 181 FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYY 240
QAAINAAIIEI TNHSVME+LMSVTG +MK+ F+ Q GV TD ++F CIISFS+FIYY
Sbjct: 180 LQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYY 239
Query: 241 VSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGF 300
SVNVT+ER+ + +LMTMMGLR+SAFWLSWGL+YAGFI IMA +AL+++S Q ++L+GF
Sbjct: 240 ASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGF 299
Query: 301 VMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW 360
++VF+LFLLYGLSL+ LAFLMS+L+KK FLTGLVVFLL VFWG LGF +LY LPA LEW
Sbjct: 300 MVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTSLYRHLPASLEW 359
Query: 361 TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYF 420
L LLSPFAF +GMAQL+HLDYD+NSNA S LI+AT FML FDT LYL L +YF
Sbjct: 360 ILSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYF 419
Query: 421 DKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEA 480
+KILP EYGHR PLFFLKS FW Q + +HV LE+E D+DP+ +D FE PEF GKEA
Sbjct: 420 EKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEA 479
Query: 481 IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS 540
IRI+N+ KEY GK +++EALK +VFDIYEGQITA+LGHSGAGK+TLLNILSGLSVPT GS
Sbjct: 480 IRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGS 539
Query: 541 VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQR 600
VT+YN+ LS MAD+EN+SK TG CPQSNVQF FLTV+ENLRLFAKIKGILP EV+KE+
Sbjct: 540 VTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEI-- 597
Query: 601 VVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLL 660
LLDEPTAGLDP SRH++WNLL
Sbjct: 598 --------------------------------------FLLDEPTAGLDPFSRHQVWNLL 619
Query: 661 KEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER 720
KE K+DRVILFSTQF+DEADILADRKVF+S GKLKCAGSSLFLKKKWGIGYHLSL LNE
Sbjct: 620 KERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEI 679
Query: 721 CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVS 780
C E+ITSLVKQHI DAKL+A+SE KL+Y LPLERTNKFPELY+DLD + GIE+YGVS
Sbjct: 680 CVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGVS 739
Query: 781 ITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVA 840
+TTLNEVFLKLEGKSTI+ESDI I G++Q + A D LVE+EQVLSS ++ RKTI GVA
Sbjct: 740 MTTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKTIGGVA 799
Query: 841 LWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT 900
LWRQQ+CAIA+VR LKLK ERK+L +LL+ F P L+E+ + YQ SY WELSP+
Sbjct: 800 LWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPHL 859
Query: 901 YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAI 960
YFL+PGQQP DPLT LL+INKTG++ID+F+ S+ QNIA+EVDAFGTRNGTDDPSYNGAI
Sbjct: 860 YFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGAI 919
Query: 961 IVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEY 1020
V +EK++ FS+ACN KRLNCFPVL+D++SNGLLG+ S HI+T+RSTF E D
Sbjct: 920 TVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNPI 979
Query: 1021 GYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL 1080
G+ + FW+ + +S PYIAMSSI DYK +A SQLRISGL PSAYWFGQALVDVSLYFL
Sbjct: 980 GFLAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFL 1039
Query: 1081 ILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWS 1140
+ + + +M YI + E+++ I ++ IQI C++GY SL+F+TYVISFIFR GRKNSGIWS
Sbjct: 1040 VFVFIYLMSYISNFEDMLLTIIHI-IQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWS 1098
Query: 1141 FFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPDSMDYLGASESE 1200
F F +V +FS+ + + F T LIPP T+IG LF+ S + S+ SE
Sbjct: 1099 FCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSHLLFSSL----FSEER 1154
Query: 1201 I---VYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGE 1257
+ +L LIP+LHF+IFLF LRCLE KK MRKDP FRISPRS+ + NPEEPEGE
Sbjct: 1155 MDVQPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNPEEPEGE 1214
Query: 1258 EEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVK 1317
+ED+QMER+RT NA+ +FDE PVIIASCLRKEYAGK+K CFSKRK KIATRNVSFCV+
Sbjct: 1215 DEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVR 1274
Query: 1318 KGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQENALWPNL 1377
KGEV+GLLGHNGAGKST+IK+ITGDTKPTAGQV+LKGSGGG+ L FLGYCPQENALWPNL
Sbjct: 1275 KGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQENALWPNL 1334
Query: 1378 TVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILG 1437
TVRQHLEVYAAVKGLRKGDA +AITRLVDALKLQDQLK+PVKTLSEGIKRKLCFVLSILG
Sbjct: 1335 TVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILG 1394
Query: 1438 NPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSG 1497
NPSVVLLDEPSTGMDPEGQQQMWQ IRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSG
Sbjct: 1395 NPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSG 1454
Query: 1498 RLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLP 1557
RLRCIGSIQHLKSKFGKDYLLEMK+KNLAQ+EPLHAEILRLFPQAA+QER+SSLMVYKLP
Sbjct: 1455 RLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFPQAARQERYSSLMVYKLP 1514
Query: 1558 VEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDLEEDFDPSVKWK 1617
VEDV+PL+QAFFKLE VKQSFDLEEYSLSQSTLEQVFLELSKEQELGD EEDFDPSVKWK
Sbjct: 1515 VEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVKWK 1574
Query: 1618 LLLQEEP 1624
LL QEEP
Sbjct: 1575 LLPQEEP 1581
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 1928 bits (4994), Expect = 0.0
Identities = 966/1546 (62%), Positives = 1208/1546 (78%), Gaps = 15/1546 (0%)
Query: 91 MNKVASAPFLKGRTIMGWPDEKSMD-ELDLNYSIDAVRVIFTDTFSYHLKFSWGHRIPMM 149
MNK+A A F+KGRT++G PDE++MD EL Y + V VIF+DTFSY LKF+WG+RIP++
Sbjct: 1 MNKMALASFMKGRTVIGTPDEETMDIELPKKYH-EMVGVIFSDTFSYRLKFNWGYRIPVI 59
Query: 150 KEHRDHSAHCQAVNEKMKCEGSEFWEKGFVAFQAAINAAIIEIATNHSVMEQLMSVTGVH 209
KEH +++ HC A++ ++ C +++W KGFVAFQAAINAAIIE+ TNHSVME+L SV G++
Sbjct: 60 KEHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGIN 119
Query: 210 MKILPFVAQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLS 269
MKI PF+++G + ++F F C++SFS+FIY+ S+NV +ER LMT+MGLRESAFWLS
Sbjct: 120 MKIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLS 179
Query: 270 WGLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPF 329
WGL Y FI IM+ MAL++ S IV TGF+++FTL+ LYGLSLI LAFLMSVLI+KP
Sbjct: 180 WGLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPM 239
Query: 330 LTGLVVFLLIVFWGILGFPALYTRLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAH 389
L GL FL VFWG LGF LY +LP L W L LLSPFAFT GMAQ+ HLD ++
Sbjct: 240 LAGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIF 299
Query: 390 LDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRA 449
D S + Y +IAT F+L FDTL YL+ TLYF+++LP + GH SPLFFLKS FW +H
Sbjct: 300 PDPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNT 359
Query: 450 NHVVLENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYE 509
+H + ENE + + + +D FEPVSPEF GKEAIRI+N+ KEY GK +VEAL+G+ FDIYE
Sbjct: 360 HHEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYE 419
Query: 510 GQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNV 569
GQITA+LGH+GAGK+TLLNILSGLSV T GS T+YN LS + D+E I K GFCPQ N
Sbjct: 420 GQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNF 479
Query: 570 QFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFG 629
QF FLTV+ENLR+FAKIKGI P EVE+EV+R++ EL+M++IQDI+A+ LSGGQ RKLT G
Sbjct: 480 QFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLG 539
Query: 630 IAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFI 689
IAILGDPQVLLLDEPTAGLDP SRHR+W+LLKE K DR+ILFSTQF+DEADILADRKVF+
Sbjct: 540 IAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFL 599
Query: 690 SNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPESITSLVKQHISDAKLTAQSEEKLVY 749
SNGKLKCAGSSLFLK+KWGIGYHLSLH NE CD E ITSL+KQHI DAKLT +SEEKLVY
Sbjct: 600 SNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVY 659
Query: 750 ILPLERTNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFLKLEGKSTIDESDIGIWGQLQ 809
LPLE+TNKFP+LY DLD+CS+QGI +Y VS+T+LNEVFL LEGKS IDE D I Q +
Sbjct: 660 SLPLEKTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEK 719
Query: 810 TDGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLWTILL 869
++ G E+EQVL S ETRK +S ALWR+Q+ A+A +RFLKL++ER++L +LL
Sbjct: 720 IHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLL 779
Query: 870 LFGISFIPQLLEHLFYESYQKSYPWELSPNTYFLSPGQQPQDPLTHLLVINKTGSTIDNF 929
+ GI+FIP +LE + Y+ ++++ WE SP+ YFLS Q P+ PLT LL++N TGS I++
Sbjct: 780 VLGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDL 839
Query: 930 LHSLRRQNIAIEVDAFGTRNGTDDPSYNGAIIVSGDEKDHRFSIACNTKRLNCFPVLLDV 989
+HSL+ Q+I +E+D F RNG+DDPSYNGAIIVSGD+KD+RFS+ACNTK+LNCFPVL+ +
Sbjct: 840 VHSLKCQDIVLEIDDFRNRNGSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGI 899
Query: 990 ISNGLLGIFNSSEHIQTDRSTFFEEHMDYEYGYRSNTFFWIPMAASFTPYIAMSSIGDYK 1049
+SN L+GIFN +E IQ + ++F + + + G+ + F + + +P+I MSSI DYK
Sbjct: 900 VSNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYK 959
Query: 1050 KKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDY-IFSPEEIIFIIQNLLIQI 1108
K SQL ISGL+PSAYW GQALVD+ LYFLIL + ++ Y IF ++ + + + + +
Sbjct: 960 KNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSW--ELMFVLV 1017
Query: 1109 LCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGT 1168
+C IG SL+FLTYV+SFIFR RKN+G WSF F I++I +Y L L
Sbjct: 1018 VCIIGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCM 1077
Query: 1169 MLIPPFTLIGSLFIFSEI----SPDSMDYLGASESEIVYLALLIPYLHFLIFLFILRCLE 1224
+ IP FTL+G + + ++ + DS+D ++ + L LIPYL +IFLF++RCLE
Sbjct: 1078 IFIPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLE 1137
Query: 1225 MNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVII 1284
M ++M KDPVFRISPRS PNPEEPE E+ED+Q ER++ NA+ + +E PVI
Sbjct: 1138 MKYGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVIT 1197
Query: 1285 ASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTK 1344
ASCL KEY KK+CFS RKKKIA RNVSFCVKKGEV+GLLGHNGAGKST+IKMITG TK
Sbjct: 1198 ASCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTK 1257
Query: 1345 PTAGQVILKGSGGG------EPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAM 1398
PTAG V+L+GS L FLGYCPQEN+LWP LT+++HLE+YAAVKGL K DA
Sbjct: 1258 PTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAA 1317
Query: 1399 IAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQ 1458
++I+RLV+ALKLQ+QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEP TGMDPEGQQQ
Sbjct: 1318 LSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQ 1377
Query: 1459 MWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLL 1518
MWQ+++AT +N ERG LLTTHYM+EAEAVCDR+A+MVSG LRCIGSIQHLK+KFG+DYLL
Sbjct: 1378 MWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLL 1437
Query: 1519 EMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSF 1578
E+K+K Q+E LH EIL+LFPQAA QER+SSLM YKLPVEDV PLS+AFFKLE +KQ+F
Sbjct: 1438 EIKMKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTF 1497
Query: 1579 DLEEYSLSQSTLEQVFLELSKEQELGDLEEDFDPSVKWKLLLQEEP 1624
+LEEYSLSQ+TLEQVFLEL KEQELG++++ D +V+WKLL QE+P
Sbjct: 1498 NLEEYSLSQATLEQVFLELCKEQELGNVDDKIDTTVEWKLLPQEDP 1543
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 1861 bits (4821), Expect = 0.0
Identities = 950/1627 (58%), Positives = 1202/1627 (73%), Gaps = 24/1627 (1%)
Query: 1 MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQM 60
M+ ++ SV QQT ALLCKN LKKWRMKR++LLEW S LL L + LF S++ V P M
Sbjct: 1 MNMKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQ-FPGM 59
Query: 61 SSMDLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLN 120
+ +LGRVD FN ++ ++ + P S TQ+IMNK A AP LKG +++G P++ MDE+ L
Sbjct: 60 APQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLE 119
Query: 121 YSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA 180
A+ +IF +TFSY L F G+ P+ KE D SAHC + C +++W +GFVA
Sbjct: 120 NLPYAMGIIFNETFSYKLIFFQGYNSPLWKE--DFSAHCWDGYGEFSCTLTKYWNRGFVA 177
Query: 181 FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYY 240
Q AIN AIIEI TNH VME+LMSVT + MK LPF+ + + + FI F ++ FS +Y+
Sbjct: 178 LQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYF 237
Query: 241 VSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGF 300
+S+NVT+ER+ +LM MMGL++SAFWLSWGL+YAGFI I++ + +I+ QI+V+TGF
Sbjct: 238 ISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTGF 297
Query: 301 VMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW 360
+++F LF LYGLSL+ L FLMSVL+KK LT LVVFLL +FWG LGF Y +LP+ LEW
Sbjct: 298 MVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEW 357
Query: 361 TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYF 420
L + SPFAFT GM Q+I LDY++N D S + Y +IAT ML+ D L+YL+L LYF
Sbjct: 358 ILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYF 417
Query: 421 DKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEA 480
DKILP SPLFFL S FQH R N V+E E D++ +D FEPV+PEF GKEA
Sbjct: 418 DKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEA 477
Query: 481 IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS 540
IRI+N+KKEY GK +VEALKG++FDIYEGQITA+LGHSGAGK++LLNIL+GLSVPT GS
Sbjct: 478 IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGS 537
Query: 541 VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQR 600
VT+YN LS M D+E I K TG CPQ NVQF LTVKENL LFAKIKGI EVE+EVQR
Sbjct: 538 VTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQR 597
Query: 601 VVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLL 660
++ EL+M+NIQD LA++LS GQ RKLTFGI ILGDPQ+LLLDEPT GLDP SR ++W+LL
Sbjct: 598 ILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL 657
Query: 661 KEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER 720
+E ++D VILFSTQ +DEADILADRKV +SNG+LKCAGSS+FLK++WG+GYHLSLH NE
Sbjct: 658 RERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEI 717
Query: 721 CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVS 780
C+PE ITS + HI DAKL +++EKLVY LPLERTN FP+L+ DLD+CS+QG+ Y +S
Sbjct: 718 CNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDIS 777
Query: 781 ITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVA 840
++TLNEVF+KLEG+STI++ Q + +D SL E+E SSF E + +S +
Sbjct: 778 MSTLNEVFMKLEGQSTIEQD------FEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMG 831
Query: 841 LWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT 900
LWR QV A+A++RFLKLK++ K L T+LL+FGI+ P ++E++ Y + WE
Sbjct: 832 LWRMQVFAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNEL 891
Query: 901 YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAI 960
YFLSPGQ PQ+P T LL+IN T S I++F+ SL+ QNI +EVD F RNGTD SYNGAI
Sbjct: 892 YFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDGLSYNGAI 951
Query: 961 IVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEY 1020
IVSG +KD+RFS+ CNTKRL+CFP+L+++ISNGLL +FN ++HI+ + S F H+
Sbjct: 952 IVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWT 1011
Query: 1021 GYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL 1080
G +FF + S +PYI M SI DYKK A SQL ISGLY SAYW GQALVDVS + L
Sbjct: 1012 GLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFIL 1071
Query: 1081 ILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWS 1140
ILLLM ++ YI + + ++ Q + ++ + GY +SLVF Y+ISFIFR RKNSG+WS
Sbjct: 1072 ILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWS 1131
Query: 1141 FFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEIS--------PDSMD 1192
F+F T +N + L +L+P +TL+G F E+ P++
Sbjct: 1132 FYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLG-FKTFLEVRDQEHYREFPEANF 1190
Query: 1193 YLGASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPE 1252
L A++ +L IPY L+F+F+LRC+E+ C KK MRKDPVFRISP+S PNPE
Sbjct: 1191 ELSATD----FLVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPE 1246
Query: 1253 EPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNV 1312
EP E+EDIQ ER+RT A+ DE PVIIASCL KEYAG+KK+CFSKRKKKIA RN+
Sbjct: 1247 EPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNI 1306
Query: 1313 SFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQENA 1372
SFCV++GE++GLLG NGAGKS++I+MI+G TKPTAG+V LKG LG LGYCPQEN
Sbjct: 1307 SFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGC--SSVLGHLGYCPQENV 1364
Query: 1373 LWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFV 1432
LWP LT+R+HLEVYAAVKGLRK DA +AI RLV A KL +QL PV+ L+ GI RKLCFV
Sbjct: 1365 LWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFV 1424
Query: 1433 LSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVA 1492
LS+LGN V+LLDEPSTG+DP GQQQMWQ I+A +NTERG LLTTH +AEAEA+CDRVA
Sbjct: 1425 LSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVA 1484
Query: 1493 IMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLM 1552
IMVSGRLRCIGSIQHLK+K GKDY+LE+K+K +Q+ +H EIL+LFPQAA QER+SSL+
Sbjct: 1485 IMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLL 1544
Query: 1553 VYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDLEEDFDP 1612
YKLPV DV PLSQ F KLE VK +F+LEEYSLSQ TLE+VFLELSKEQE+G+ +E+ D
Sbjct: 1545 TYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDT 1604
Query: 1613 SVKWKLL 1619
+++WKLL
Sbjct: 1605 TMRWKLL 1611
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 1219 bits (3153), Expect = 0.0
Identities = 684/1633 (41%), Positives = 1006/1633 (61%), Gaps = 49/1633 (3%)
Query: 4 RRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQMSSM 63
R + V +QT LL KN L K R K+ ++ E LF L LF + S +H ++ ++
Sbjct: 6 REVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFP-LFFLFWLILISMMHPNKKYEEVPNI 64
Query: 64 DLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLNYSI 123
+L +D F +N ++ + P + T IM KV++ + +EK M L+
Sbjct: 65 ELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPS 124
Query: 124 DAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVAFQA 183
+ V V+F D+ SY L+F + IP+ + D A C CE +++W GF QA
Sbjct: 125 NFVGVVFKDSMSYELRF-FPDMIPVSSIYMDSRAGCSK-----SCEAAQYWSSGFTVLQA 178
Query: 184 AINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYYVSV 243
+I+AAII++ TN S+ ++L S V M V + + +I+FS F Y++++
Sbjct: 179 SIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAI 238
Query: 244 NVTQERQY-ITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVM 302
++ E++ I + +MGL ++AFWLSW L+Y I +M+ LMA+I ++ + + ++
Sbjct: 239 HIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIV 298
Query: 303 VFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPA-LYTRLPAFLEWT 361
+F LF LYGLS + A +++ L KK G+V F + V +G +G L P L W
Sbjct: 299 IFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVW- 357
Query: 362 LCLLSPFA---FTVGMAQLIHLDYDVNSNAHLDS-SQNPYLIIATLFMLVFDTLLYLVLT 417
L SPF F +G+AQ++HL+ D N A + + PY +I T+ ML +++ Y++L
Sbjct: 358 --LFSPFCHCTFVIGIAQVMHLE-DFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLA 414
Query: 418 LYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCG 477
+Y D+++P E+G R S L+FLK +W + R + E + + + ++ EPVS EF G
Sbjct: 415 VYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVG 474
Query: 478 KEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPT 537
KEAIRI ++K Y K E VEAL+ + FDIYEGQITALLGHSG GK+TL+NIL GL P+
Sbjct: 475 KEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPS 534
Query: 538 SGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKE 597
G ++Y H +S + ++ K G CPQ ++ F LTV+ENL + A IKGI + + +E
Sbjct: 535 DGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQE 594
Query: 598 VQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIW 657
VQ+V+ +L+M+ I+D A+ LSGGQ RKL+ GIA+LG+P++LLLDEPTAG+DP SRH +W
Sbjct: 595 VQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVW 654
Query: 658 NLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHL 717
NLLK K++RV +FST F+DEADILADRK IS G LKC GSS+FLK KWGIGY LS+++
Sbjct: 655 NLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYI 714
Query: 718 NERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDY 777
++ C ES++SLVKQHI A L Q++++LVY LP + +KF L+ LD SN G+ Y
Sbjct: 715 DKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISY 774
Query: 778 GVSITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKT-I 836
GVS+TTL +VFLKLE ++ ID++D ++ Q + D S E+EQ L ET+ +
Sbjct: 775 GVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALV 834
Query: 837 SGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKS-YPWE 895
S ++LW+QQ+ IAK F LK+E KS+ ++LLL I F Q+ L + S++ + P +
Sbjct: 835 STMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIK 894
Query: 896 LSPNTYFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPS 955
L P+ YFL PG +P T LL+ N S I + + QNI + + +
Sbjct: 895 LVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTM--INDSDYVSVAP 952
Query: 956 YNGAIIVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEH 1015
++ A+ V EKD+ F+ N+ + P+L+++ISN L N +E IQ + FF+E
Sbjct: 953 HSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEI 1012
Query: 1016 MDYEYGYRSNTFFWIPM----AASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQA 1071
D ++ +F + + PY AM + ++K KA++QL++SGL PSAYW GQA
Sbjct: 1013 TDIV--FKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQA 1070
Query: 1072 LVDVSLYFLILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRN 1131
+VD+ L+F+IL+LM + + + F L + C IGYV S++ TY+ SF F+
Sbjct: 1071 VVDIPLFFIILILM-LGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKK 1129
Query: 1132 GRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGTML-------IPPFTLIGSLFIFS 1184
WSF + + + I T++ F+G T+L IP + L+G L F
Sbjct: 1130 ILNTKEFWSFIYSVAALACIAITEIT--FFMGYTIATILHYAFCIIIPIYPLLGCLISFI 1187
Query: 1185 EISPDSM--DYLGASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFR-IS 1241
+IS ++ + + + + +A++ PYL ++++F+L+ E + +RKDP FR +S
Sbjct: 1188 KISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLS 1247
Query: 1242 PRS-NAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCF 1300
+S N P P + E E+ED++ ER++ M + +E P I+ S L KEY KK
Sbjct: 1248 TKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLL 1307
Query: 1301 SKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVIL-----KGS 1355
S++ KK+AT+ +SFCVKKGE++GLLG NGAGKST I ++ GD +PT+GQV L + S
Sbjct: 1308 SRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETS 1367
Query: 1356 GGGEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLK 1415
+ L +GYCPQ N LWP+ T+++H E+Y AVKG+ D I+R+ AL L++ L+
Sbjct: 1368 EDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQ 1427
Query: 1416 APVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGAL 1475
VK L GIKRKLCF LS+LGNP + LLDEPSTGMDP+ +Q MW+ IR F+N +R A+
Sbjct: 1428 KTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAI 1487
Query: 1476 LTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNL---AQMEPLH 1532
LTTHYM EAEAVCDRVAIMVSG+LRCIG++QHLKSKFGK Y LE+KLK+ +++ L
Sbjct: 1488 LTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQ 1547
Query: 1533 AEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQ 1592
EI +FP A++QE FSS++ YK+P EDV+ LSQ+FFKLE K +F +EEYS SQ+TLEQ
Sbjct: 1548 REIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQ 1607
Query: 1593 VFLELSKEQELGD 1605
VF+EL+KEQE D
Sbjct: 1608 VFVELTKEQEEED 1620
Score = 177 bits (448), Expect = 1e-43
Identities = 149/611 (24%), Positives = 280/611 (45%), Gaps = 48/611 (7%)
Query: 239 YYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAG--FILIMATLMALIVKSAQIVV 296
Y+ N + + + + GL SA+W+ ++ FI+++ L +L+ +
Sbjct: 1038 YFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYF 1097
Query: 297 LT-GFVMVFTLFLLYGLSLITLAFLMSVLIKK--------PFLTGLVVFLLIVFWGILGF 347
T F+ V + Y S+I ++ S KK F+ + I I F
Sbjct: 1098 YTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFF 1157
Query: 348 PALYTRLPAFLEWTLCLLSPFAFTVG-MAQLIHLDYDVNSNAHLDSSQNPYLIIATLFML 406
YT + L + C++ P +G + I + + N ++D+ NP+ L +
Sbjct: 1158 MG-YT-IATILHYAFCIIIPIYPLLGCLISFIKISWK-NVRKNVDT-YNPW---DRLSVA 1210
Query: 407 VFDTLLYLVLTLYFDKILPAEYGHRC---SPLFFLKSCFWFQHGRANHVVLENETDSDPT 463
V L VL ++ + +YG R P F ++ R +NE + +
Sbjct: 1211 VISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFF--RNLSTKSKNRKLPEPPDNEDEDEDV 1268
Query: 464 PNDCFEPVSPEFCG----KEAIRIKNLKKEYAGKCE-------RVEALKGVVFDIYEGQI 512
+ + C K +I + NL KEY K + + A K + F + +G+I
Sbjct: 1269 KAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEI 1328
Query: 513 TALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFG 572
LLG +GAGK+T++NIL G PTSG V + +++ D +++ K G+CPQ N +
Sbjct: 1329 LGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSL-KCMGYCPQINPLWP 1387
Query: 573 FLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAI 632
T++E+ ++ +KG+ ++++ + R+ L+++ + L G RKL F +++
Sbjct: 1388 DTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSM 1447
Query: 633 LGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDR--VILFSTQFIDEADILADRKVFIS 690
LG+PQ+ LLDEP+ G+DP ++ +W ++ +R + +T +++EA+ + DR +
Sbjct: 1448 LGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMV 1507
Query: 691 NGKLKCAGSSLFLKKKWGIGYHLSLHLN---ERCDPESITSLVKQHISDAKLTAQSEEKL 747
+G+L+C G+ LK K+G GY L + L E + + + ++ +A L
Sbjct: 1508 SGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSIL 1567
Query: 748 VYILPLERTNKFPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKLEGKSTIDESDIGI-- 804
Y +P E + + L+ + IE+Y S TL +VF++L + +++ G
Sbjct: 1568 AYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLN 1627
Query: 805 ----WGQLQTD 811
W + Q D
Sbjct: 1628 STLWWERTQED 1638
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 1219 bits (3153), Expect = 0.0
Identities = 684/1633 (41%), Positives = 1006/1633 (61%), Gaps = 49/1633 (3%)
Query: 4 RRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQMSSM 63
R + V +QT LL KN L K R K+ ++ E LF L LF + S +H ++ ++
Sbjct: 6 REVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFP-LFFLFWLILISMMHPNKKYEEVPNI 64
Query: 64 DLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLNYSI 123
+L +D F +N ++ + P + T IM KV++ + +EK M L+
Sbjct: 65 ELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPS 124
Query: 124 DAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVAFQA 183
+ V V+F D+ SY L+F + IP+ + D A C CE +++W GF QA
Sbjct: 125 NFVGVVFKDSMSYELRF-FPDMIPVSSIYMDSRAGCSK-----SCEAAQYWSSGFTVLQA 178
Query: 184 AINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYYVSV 243
+I+AAII++ TN S+ ++L S V M V + + +I+FS F Y++++
Sbjct: 179 SIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAI 238
Query: 244 NVTQERQY-ITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVM 302
++ E++ I + +MGL ++AFWLSW L+Y I +M+ LMA+I ++ + + ++
Sbjct: 239 HIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIV 298
Query: 303 VFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPA-LYTRLPAFLEWT 361
+F LF LYGLS + A +++ L KK G+V F + V +G +G L P L W
Sbjct: 299 IFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVW- 357
Query: 362 LCLLSPFA---FTVGMAQLIHLDYDVNSNAHLDS-SQNPYLIIATLFMLVFDTLLYLVLT 417
L SPF F +G+AQ++HL+ D N A + + PY +I T+ ML +++ Y++L
Sbjct: 358 --LFSPFCHCTFVIGIAQVMHLE-DFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLA 414
Query: 418 LYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCG 477
+Y D+++P E+G R S L+FLK +W + R + E + + + ++ EPVS EF G
Sbjct: 415 VYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVG 474
Query: 478 KEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPT 537
KEAIRI ++K Y K E VEAL+ + FDIYEGQITALLGHSG GK+TL+NIL GL P+
Sbjct: 475 KEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPS 534
Query: 538 SGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKE 597
G ++Y H +S + ++ K G CPQ ++ F LTV+ENL + A IKGI + + +E
Sbjct: 535 DGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQE 594
Query: 598 VQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIW 657
VQ+V+ +L+M+ I+D A+ LSGGQ RKL+ GIA+LG+P++LLLDEPTAG+DP SRH +W
Sbjct: 595 VQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVW 654
Query: 658 NLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHL 717
NLLK K++RV +FST F+DEADILADRK IS G LKC GSS+FLK KWGIGY LS+++
Sbjct: 655 NLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYI 714
Query: 718 NERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDY 777
++ C ES++SLVKQHI A L Q++++LVY LP + +KF L+ LD SN G+ Y
Sbjct: 715 DKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISY 774
Query: 778 GVSITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKT-I 836
GVS+TTL +VFLKLE ++ ID++D ++ Q + D S E+EQ L ET+ +
Sbjct: 775 GVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALV 834
Query: 837 SGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKS-YPWE 895
S ++LW+QQ+ IAK F LK+E KS+ ++LLL I F Q+ L + S++ + P +
Sbjct: 835 STMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIK 894
Query: 896 LSPNTYFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPS 955
L P+ YFL PG +P T LL+ N S I + + QNI + + +
Sbjct: 895 LVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTM--INDSDYVSVAP 952
Query: 956 YNGAIIVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEH 1015
++ A+ V EKD+ F+ N+ + P+L+++ISN L N +E IQ + FF+E
Sbjct: 953 HSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEI 1012
Query: 1016 MDYEYGYRSNTFFWIPM----AASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQA 1071
D ++ +F + + PY AM + ++K KA++QL++SGL PSAYW GQA
Sbjct: 1013 TDIV--FKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQA 1070
Query: 1072 LVDVSLYFLILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRN 1131
+VD+ L+F+IL+LM + + + F L + C IGYV S++ TY+ SF F+
Sbjct: 1071 VVDIPLFFIILILM-LGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKK 1129
Query: 1132 GRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGTML-------IPPFTLIGSLFIFS 1184
WSF + + + I T++ F+G T+L IP + L+G L F
Sbjct: 1130 ILNTKEFWSFIYSVAALACIAITEIT--FFMGYTIATILHYAFCIIIPIYPLLGCLISFI 1187
Query: 1185 EISPDSM--DYLGASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFR-IS 1241
+IS ++ + + + + +A++ PYL ++++F+L+ E + +RKDP FR +S
Sbjct: 1188 KISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLS 1247
Query: 1242 PRS-NAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCF 1300
+S N P P + E E+ED++ ER++ M + +E P I+ S L KEY KK
Sbjct: 1248 TKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLL 1307
Query: 1301 SKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVIL-----KGS 1355
S++ KK+AT+ +SFCVKKGE++GLLG NGAGKST I ++ GD +PT+GQV L + S
Sbjct: 1308 SRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETS 1367
Query: 1356 GGGEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLK 1415
+ L +GYCPQ N LWP+ T+++H E+Y AVKG+ D I+R+ AL L++ L+
Sbjct: 1368 EDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQ 1427
Query: 1416 APVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGAL 1475
VK L GIKRKLCF LS+LGNP + LLDEPSTGMDP+ +Q MW+ IR F+N +R A+
Sbjct: 1428 KTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAI 1487
Query: 1476 LTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNL---AQMEPLH 1532
LTTHYM EAEAVCDRVAIMVSG+LRCIG++QHLKSKFGK Y LE+KLK+ +++ L
Sbjct: 1488 LTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQ 1547
Query: 1533 AEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQ 1592
EI +FP A++QE FSS++ YK+P EDV+ LSQ+FFKLE K +F +EEYS SQ+TLEQ
Sbjct: 1548 REIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQ 1607
Query: 1593 VFLELSKEQELGD 1605
VF+EL+KEQE D
Sbjct: 1608 VFVELTKEQEEED 1620
Score = 177 bits (448), Expect = 1e-43
Identities = 149/611 (24%), Positives = 280/611 (45%), Gaps = 48/611 (7%)
Query: 239 YYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAG--FILIMATLMALIVKSAQIVV 296
Y+ N + + + + GL SA+W+ ++ FI+++ L +L+ +
Sbjct: 1038 YFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYF 1097
Query: 297 LT-GFVMVFTLFLLYGLSLITLAFLMSVLIKK--------PFLTGLVVFLLIVFWGILGF 347
T F+ V + Y S+I ++ S KK F+ + I I F
Sbjct: 1098 YTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFF 1157
Query: 348 PALYTRLPAFLEWTLCLLSPFAFTVG-MAQLIHLDYDVNSNAHLDSSQNPYLIIATLFML 406
YT + L + C++ P +G + I + + N ++D+ NP+ L +
Sbjct: 1158 MG-YT-IATILHYAFCIIIPIYPLLGCLISFIKISWK-NVRKNVDT-YNPW---DRLSVA 1210
Query: 407 VFDTLLYLVLTLYFDKILPAEYGHRC---SPLFFLKSCFWFQHGRANHVVLENETDSDPT 463
V L VL ++ + +YG R P F ++ R +NE + +
Sbjct: 1211 VISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFF--RNLSTKSKNRKLPEPPDNEDEDEDV 1268
Query: 464 PNDCFEPVSPEFCG----KEAIRIKNLKKEYAGKCE-------RVEALKGVVFDIYEGQI 512
+ + C K +I + NL KEY K + + A K + F + +G+I
Sbjct: 1269 KAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEI 1328
Query: 513 TALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFG 572
LLG +GAGK+T++NIL G PTSG V + +++ D +++ K G+CPQ N +
Sbjct: 1329 LGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSL-KCMGYCPQINPLWP 1387
Query: 573 FLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAI 632
T++E+ ++ +KG+ ++++ + R+ L+++ + L G RKL F +++
Sbjct: 1388 DTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSM 1447
Query: 633 LGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDR--VILFSTQFIDEADILADRKVFIS 690
LG+PQ+ LLDEP+ G+DP ++ +W ++ +R + +T +++EA+ + DR +
Sbjct: 1448 LGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMV 1507
Query: 691 NGKLKCAGSSLFLKKKWGIGYHLSLHLN---ERCDPESITSLVKQHISDAKLTAQSEEKL 747
+G+L+C G+ LK K+G GY L + L E + + + ++ +A L
Sbjct: 1508 SGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSIL 1567
Query: 748 VYILPLERTNKFPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKLEGKSTIDESDIGI-- 804
Y +P E + + L+ + IE+Y S TL +VF++L + +++ G
Sbjct: 1568 AYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLN 1627
Query: 805 ----WGQLQTD 811
W + Q D
Sbjct: 1628 STLWWERTQED 1638
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 342 bits (878), Expect = 1e-93
Identities = 270/871 (30%), Positives = 438/871 (50%), Gaps = 96/871 (11%)
Query: 6 MSVGQQTWALLCKNCLKKWRMKRQTLLEW----LFSFLLV-LFLYLFFSNLHQVHDTPQM 60
M+V +Q LL KN + R T+LE LFS +L+ L L + N+ P
Sbjct: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQ 60
Query: 61 SSMDLGRVDSF---NDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDEL 117
S +L +F DT + +A+ P + + + + + G+P EK ++
Sbjct: 61 SIQELPLFFTFPPPGDT-WELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDY 119
Query: 118 ---DLNYSIDAVRVIFTDTFS-----------YHLKFSWGHRIPMMKE------HRDHSA 157
D S V+F F+ YHL+FS+ R M +
Sbjct: 120 IRYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGW 179
Query: 158 HCQAV---------NEKMKCEGSE--FWEKGFVAFQAAINAAIIEIATNHSVME--QLMS 204
H ++ E +G E + +GF+A Q A++ AI+E + + + Q ++
Sbjct: 180 HTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLT 239
Query: 205 VTGVHMKILPFVAQGG-VATDFFI-FFCIISFSTFIYYVSVNVTQERQY-ITSLMTMMGL 261
VT PF+A VA + + ++SF+ ++ V QE++ + M MMGL
Sbjct: 240 VTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGL 299
Query: 262 RESAFWLSWGLMYAGFILIMATLMALIV-----KSAQIVVLTGFVMVFTLFLLYGLSLIT 316
W +W L++ F+LI A+ M L+ + ++ + +V L + +S I+
Sbjct: 300 SSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTIS 359
Query: 317 LAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFL-----EWTL-------CL 364
+F++S K + F G L F +T +P F W CL
Sbjct: 360 FSFMVSTFFSKANMAA-------AFGGFLYF---FTYIPYFFVAPRYNWMTLSQKLCSCL 409
Query: 365 LSPFAFTVGMAQLIHLDY---------DVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLV 415
LS A +G AQLI D+ S ++D + L ML+ D++LY +
Sbjct: 410 LSNVAMAMG-AQLIGKFEAKGMGIQWRDLLSPVNVDDD---FCFGQVLGMLLLDSVLYGL 465
Query: 416 LTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTP---NDCFEPVS 472
+T Y + + P ++G FF+ +W G+ V + E DSDP N+ FE
Sbjct: 466 VTWYMEAVFPGQFGVPQPWYFFIMPSYWC--GKPRAVAGKEEEDSDPEKALRNEYFEAEP 523
Query: 473 PEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSG 532
+ I+IK+L K + + A++ + ++YEGQIT LLGH+GAGKTT L++L+G
Sbjct: 524 EDLVA--GIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTG 581
Query: 533 LSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPH 592
L PTSG + + +S+ D+ I K G CPQ ++ F LTV E+L +A++KG+
Sbjct: 582 LFPPTSGRAYISGYEISQ--DMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQ 639
Query: 593 EVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLS 652
+ +EV++++ + +E+ + ++ LSGG RKL+ GIA++ +VL+LDEPT+G+D +S
Sbjct: 640 KCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAIS 699
Query: 653 RHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYH 712
R IW+LL+ KSDR I+ +T F+DEAD+L DR ++ G+L+C GSSLFLK+K+G GYH
Sbjct: 700 RRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYH 759
Query: 713 LSLHLNERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQ 772
++L C+PE I+ LV H+ +A L + + +L +ILP E T++F L+ L++ +
Sbjct: 760 MTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKE 819
Query: 773 -GIEDYGVSITTLNEVFLKLEGKSTIDESDI 802
GI +G SITT+ EVFL++ GK DI
Sbjct: 820 LGIASFGASITTMEEVFLRV-GKLVDSSMDI 849
Score = 214 bits (545), Expect = 5e-55
Identities = 193/666 (28%), Positives = 313/666 (46%), Gaps = 75/666 (11%)
Query: 979 RLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEYGYRSNTFFWIPMAASFTP 1038
+L C P V+SN +Q + F E ++ N F + AS
Sbjct: 1063 KLLCGPHASIVVSN----FPQPRSALQAAKDQFNEGRKGFDIAL--NLLFAMAFLASTFS 1116
Query: 1039 YIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFSPEEII 1098
+A+S K H Q +SG++ +++W L D+ + + LL+ ++ F
Sbjct: 1117 ILAVSERAVQAK--HVQF-VSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFT 1173
Query: 1099 ---FIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFF--------FLIVV 1147
+ LL+ +L Y +++ L Y+++F F + F FL+V
Sbjct: 1174 RDGHMADTLLLLLL----YGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVT 1229
Query: 1148 IFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPDSMDYLGASESEIVYL--- 1204
I I A L E L +++P L ++ F E + ++ Y +SE Y
Sbjct: 1230 IMRIPAVKLEELSKT-LDHVFLVLPNHCLGMAVSSFYE-NYETRRYCTSSEVAAHYCKKY 1287
Query: 1205 ---------------------ALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPR 1243
++ +LI LF++ E N ++L R
Sbjct: 1288 NIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLI---ETNLLQRLRGILCALRRRRT 1344
Query: 1244 SNAIFPN-PEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSK 1302
++ P PE ++D+ ER R + A + TP+II L K Y +
Sbjct: 1345 LTELYTRMPVLPE--DQDVADERTRIL-APSPDSLLHTPLIIKE-LSKVY--------EQ 1392
Query: 1303 RKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG----SGGG 1358
R +A +S V+KGE GLLG NGAGK+TT KM+TG+ T+G + G S G
Sbjct: 1393 RVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVG 1452
Query: 1359 EPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPV 1418
+ +GYCPQ +AL ++T R+ L +YA ++G+ + + + L L+ V
Sbjct: 1453 KVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLV 1512
Query: 1419 KTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTT 1478
+T S G KRKL ++++G P+V+ LDEPSTGMDP ++ +W + A R + + ++T+
Sbjct: 1513 RTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTV-ARARESGKAIIITS 1571
Query: 1479 HYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLH---AEI 1535
H M E EA+C R+AIMV G+ +C+GS QHLKSKFG Y L K+++ Q E L A +
Sbjct: 1572 HSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFV 1631
Query: 1536 LRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFL 1595
FP + ++ ++ Y LP D+ ++ F LE K+ + +++YS+SQ +LEQVFL
Sbjct: 1632 DLTFPGSVLEDEHQGMVHYHLPGRDL-SWAKVFGILEKAKEKYGVDDYSVSQISLEQVFL 1690
Query: 1596 ELSKEQ 1601
+ Q
Sbjct: 1691 SFAHLQ 1696
Score = 176 bits (446), Expect = 2e-43
Identities = 105/347 (30%), Positives = 188/347 (54%), Gaps = 13/347 (3%)
Query: 1257 EEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCV 1316
EEED E+ A+ F+ P + + ++ ++ K +K + A R+++ +
Sbjct: 504 EEEDSDPEK-----ALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNK--DRAAVRDLNLNL 556
Query: 1317 KKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPL----GFLGYCPQENA 1372
+G++ LLGHNGAGK+TT+ M+TG PT+G+ + G + + LG CPQ +
Sbjct: 557 YEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDI 616
Query: 1373 LWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFV 1432
L+ NLTV +HL YA +KGL + + +++ + L+D+ + + LS G++RKL
Sbjct: 617 LFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIG 676
Query: 1433 LSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVA 1492
++++ V++LDEP++GMD ++ +W +++ + ++R +LTTH+M EA+ + DR+A
Sbjct: 677 IALIAGSKVLILDEPTSGMDAISRRAIWDLLQR--QKSDRTIVLTTHFMDEADLLGDRIA 734
Query: 1493 IMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLM 1552
IM G L+C GS LK K+G Y + + + E + + P A + + +
Sbjct: 735 IMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAEL 794
Query: 1553 VYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSK 1599
+ LP E F KLE ++ + + S +T+E+VFL + K
Sbjct: 795 SFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGK 841
Score = 152 bits (383), Expect = 3e-36
Identities = 96/323 (29%), Positives = 171/323 (52%), Gaps = 9/323 (2%)
Query: 472 SPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILS 531
SP+ + IK L K Y + + A+ + + +G+ LLG +GAGKTT +L+
Sbjct: 1372 SPDSLLHTPLIIKELSKVYEQRVPLL-AVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLT 1430
Query: 532 GLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILP 591
G TSG V H +S +D+ + + G+CPQ + +T +E L ++A+++GI
Sbjct: 1431 GEESLTSGDAFVGGHRIS--SDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPE 1488
Query: 592 HEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPL 651
+ V+ ++ L +E + L + SGG RKL+ GIA++G+P V+ LDEP+ G+DP+
Sbjct: 1489 RHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPV 1548
Query: 652 SRHRIWNLLKEGK-SDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIG 710
+R +W+ + + S + I+ ++ ++E + L R + G+ KC GS LK K+G G
Sbjct: 1549 ARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSG 1608
Query: 711 YHLSLHLNERCDPESI---TSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLD 767
Y L + E++ + V + L + + + Y LP R + +++ L+
Sbjct: 1609 YSLRAKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLP-GRDLSWAKVFGILE 1667
Query: 768 RCSNQ-GIEDYGVSITTLNEVFL 789
+ + G++DY VS +L +VFL
Sbjct: 1668 KAKEKYGVDDYSVSQISLEQVFL 1690
Score = 31.2 bits (69), Expect = 8.5
Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 12/105 (11%)
Query: 260 GLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTG---FVMVFTLFLLYGLSLIT 316
G+ ++FWLS L LI + L+ ++ K+ + T L LLYG ++I
Sbjct: 1135 GVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIP 1194
Query: 317 LAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALY-----TRLPA 356
L +LM+ FL + + + IL A + R+PA
Sbjct: 1195 LMYLMNFF----FLGAATAYTRLTIFNILSGIATFLMVTIMRIPA 1235
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 296 bits (757), Expect = 1e-79
Identities = 223/777 (28%), Positives = 376/777 (48%), Gaps = 101/777 (12%)
Query: 107 GWPDEKSMDELDLNYSI-DAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEK 165
G+PDE+S+ LN + D V V + F S + + R +S+ + NE
Sbjct: 582 GFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHY--KIRQNSSFTEKTNEI 639
Query: 166 MKCE--------GSEFWEKGFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVA 217
+ G ++ GFV Q + AII+ H V+E G ++++ P+
Sbjct: 640 RRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVEP-----GSYVQMFPYPC 694
Query: 218 QGGVATDFFIF-------FCIISFSTFIYYVSVN----VTQERQYITSLMTMMGLRESAF 266
D F+F C++ +++Y V++ V ++ + +M MGL +
Sbjct: 695 Y---TRDDFLFVIEHMMPLCMVI--SWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVH 749
Query: 267 WLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIK 326
W++W + + I T + I+K Q+++ + V+++ +Y ++ I FL+SVL
Sbjct: 750 WVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYS 809
Query: 327 KPFLT----GLVVFLLIVFWGILGF--PALYTRLPAFLEWTLCLLSPFAFTVGMAQL--- 377
K L G++ FL V + + + ++ AF + L+S AF +G
Sbjct: 810 KAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALY 869
Query: 378 ----IHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCS 433
+ + + S + ++ L+ T ML+ D ++Y +LT Y + + P YG
Sbjct: 870 EVAGVGIQWHTFSQSPVEGDDFNLLLAVT--MLMVDAVVYGILTWYIEAVHPGMYGLPRP 927
Query: 434 PLFFLKSCFWFQHGRAN------------HVVLENETDSDPTPNDCFEPVSPEFCGKE-- 479
F L+ +W GR + + E + + FE E G E
Sbjct: 928 WYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFE----ETRGMEEE 983
Query: 480 ------AIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGL 533
+ + L K Y K ++ AL + ++YE Q+ + LGH+GAGKTT ++IL+GL
Sbjct: 984 PTHLPLVVCVDKLTKVY--KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGL 1041
Query: 534 SVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHE 593
PTSGS T+Y H + +++ I K G CPQ NV F LTV+E+L ++++K + E
Sbjct: 1042 FPPTSGSATIYGHDIR--TEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEE 1099
Query: 594 VEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSR 653
+ +E+ +++++LE+ N + L Q LSGG RKL+ IA +G + ++LDEPTAG+DP +R
Sbjct: 1100 IRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYAR 1159
Query: 654 HRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHL 713
IW+L+ + K R IL ST +DEAD+L DR IS+GKLKC GS LFLK +G GY L
Sbjct: 1160 RAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRL 1219
Query: 714 SLHLN----------------------ERCDPESITSLVKQHISDAKLTAQSEEKLVYIL 751
+L C ++ +++H++ L + + +L YIL
Sbjct: 1220 TLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYIL 1279
Query: 752 PLERTNK--FPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKL-EGKSTIDESDIGI 804
P E K F L++ L+R + + +G+ TTL EVFLK+ E +++ S+ +
Sbjct: 1280 PSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADV 1336
Score = 228 bits (580), Expect = 5e-59
Identities = 132/368 (35%), Positives = 211/368 (57%), Gaps = 17/368 (4%)
Query: 1249 PNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIA 1308
P +P ++ D+ ER R + A D ++ L K Y +K + +A
Sbjct: 2022 PVSTKPVEDDVDVASERQRVLRGDADND-----MVKIENLTKVYKSRKIG------RILA 2070
Query: 1309 TRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPL----GFL 1364
+ V+ GE GLLG NGAGK++T KM+TGD T G+ + G + L L
Sbjct: 2071 VDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSL 2130
Query: 1365 GYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEG 1424
GYCPQ +AL+ LT R+HL++Y ++G+ D + ++ L+L P T S G
Sbjct: 2131 GYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGG 2190
Query: 1425 IKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEA 1484
KRKL ++++G P+ + LDEP+TGMDP+ ++ +W +I + T R +LT+H M E
Sbjct: 2191 NKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIK-TGRSVVLTSHSMEEC 2249
Query: 1485 EAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQ 1544
EA+C R+AIMV+GRLRC+GSIQHLK++FG Y++ ++ K+ ++ + R FP+A
Sbjct: 2250 EALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAML 2309
Query: 1545 QERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELG 1604
+ER + + Y+L E + L+Q F K+E V +E+YS+SQ+TL+ VF+ +K+Q
Sbjct: 2310 KERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2368
Query: 1605 DLEEDFDP 1612
+++ +P
Sbjct: 2369 LEQQETEP 2376
Score = 176 bits (446), Expect = 2e-43
Identities = 153/631 (24%), Positives = 291/631 (46%), Gaps = 63/631 (9%)
Query: 194 TNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFI--YYVSVNVTQERQY 251
TNH + + S++ L ++ QG TD I II +F+ +V V ++
Sbjct: 1771 TNHPMNKTSASLS------LDYLLQG---TDVVIAIFIIVAMSFVPASFVVFLVAEKSTK 1821
Query: 252 ITSLMTMMGLRESAFWLS---WGLMYAGFILIMATLMALIVKSAQIVVLTG---FVMVFT 305
L + G +WL+ W ++ L+ AT +I+ + T F V +
Sbjct: 1822 AKHLQFVSGCNPIIYWLANYVWDMLN---YLVPATCCVIILFVFDLPAYTSPTNFPAVLS 1878
Query: 306 LFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTR-----------L 354
LFLLYG S+ + + S + P + + ++ +F GI A + +
Sbjct: 1879 LFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVV 1938
Query: 355 PAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAHL---DSSQNPY---LIIATLFMLVF 408
++L+ + + G+ ++ + +Y A + D ++P+ ++ L +
Sbjct: 1939 NSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAV 1998
Query: 409 DTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCF 468
+ ++ +LT+ +Y P Q + +E++ D
Sbjct: 1999 EGVVGFLLTIM------CQYNFLRRP----------QRMPVSTKPVEDDVDVASER---- 2038
Query: 469 EPVSPEFCGKEAIRIKNLKKEYAG-KCERVEALKGVVFDIYEGQITALLGHSGAGKTTLL 527
+ V + ++I+NL K Y K R+ A+ + + G+ LLG +GAGKT+
Sbjct: 2039 QRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTF 2098
Query: 528 NILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIK 587
+L+G T G V H++ + ++ + + G+CPQ + F LT +E+L+L+ +++
Sbjct: 2099 KMLTGDESTTGGEAFVNGHSV--LKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLR 2156
Query: 588 GILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAG 647
GI + + V+ +++LE+ D A SGG RKL+ IA++G P + LDEPT G
Sbjct: 2157 GISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTG 2216
Query: 648 LDPLSRHRIWNLLKE-GKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKK 706
+DP +R +WNL+ + K+ R ++ ++ ++E + L R + NG+L+C GS LK +
Sbjct: 2217 MDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNR 2276
Query: 707 WGIGYHLSLHLNERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDL 766
+G GY +++ + + ++ +A L + K+ Y L E + +++ +
Sbjct: 2277 FGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHIS-LAQVFSKM 2335
Query: 767 DRCSN-QGIEDYGVSITTLNEVFLKLEGKST 796
++ S GIEDY VS TTL+ VF+ K +
Sbjct: 2336 EQVSGVLGIEDYSVSQTTLDNVFVNFAKKQS 2366
Score = 161 bits (408), Expect = 4e-39
Identities = 109/343 (31%), Positives = 173/343 (50%), Gaps = 31/343 (9%)
Query: 1302 KRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG----SGG 1357
K KK+A +S + + +V+ LGHNGAGK+TT+ ++TG PT+G + G +
Sbjct: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
Query: 1358 GEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAP 1417
E LG CPQ N L+ LTV +HL Y+ +K + + + + ++++ L+L ++ +
Sbjct: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSL 1120
Query: 1418 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLT 1477
V+TLS G+KRKL ++ +G ++LDEP+ G+DP ++ +W +I R LL+
Sbjct: 1121 VQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK--YKPGRTILLS 1178
Query: 1478 THYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILR 1537
TH+M EA+ + DR+AI+ G+L+C GS LK +G Y L + + P +
Sbjct: 1179 THHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLAS 1238
Query: 1538 LFPQAAQQERFSSLMV----------------------YKLPVEDVR--PLSQAFFKLEI 1573
P A S L V Y LP E + + F LE
Sbjct: 1239 SPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLER 1298
Query: 1574 VKQSFDLEEYSLSQSTLEQVFLELSKE-QELGDLEEDFDPSVK 1615
+ L + L +TLE+VFL++S+E Q L + E D S K
Sbjct: 1299 SLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRK 1341
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 296 bits (757), Expect = 1e-79
Identities = 223/777 (28%), Positives = 376/777 (48%), Gaps = 101/777 (12%)
Query: 107 GWPDEKSMDELDLNYSI-DAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEK 165
G+PDE+S+ LN + D V V + F S + + R +S+ + NE
Sbjct: 612 GFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHY--KIRQNSSFTEKTNEI 669
Query: 166 MKCE--------GSEFWEKGFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVA 217
+ G ++ GFV Q + AII+ H V+E G ++++ P+
Sbjct: 670 RRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVEP-----GSYVQMFPYPC 724
Query: 218 QGGVATDFFIF-------FCIISFSTFIYYVSVN----VTQERQYITSLMTMMGLRESAF 266
D F+F C++ +++Y V++ V ++ + +M MGL +
Sbjct: 725 Y---TRDDFLFVIEHMMPLCMVI--SWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVH 779
Query: 267 WLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIK 326
W++W + + I T + I+K Q+++ + V+++ +Y ++ I FL+SVL
Sbjct: 780 WVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYS 839
Query: 327 KPFLT----GLVVFLLIVFWGILGF--PALYTRLPAFLEWTLCLLSPFAFTVGMAQL--- 377
K L G++ FL V + + + ++ AF + L+S AF +G
Sbjct: 840 KAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALY 899
Query: 378 ----IHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCS 433
+ + + S + ++ L+ T ML+ D ++Y +LT Y + + P YG
Sbjct: 900 EVAGVGIQWHTFSQSPVEGDDFNLLLAVT--MLMVDAVVYGILTWYIEAVHPGMYGLPRP 957
Query: 434 PLFFLKSCFWFQHGRAN------------HVVLENETDSDPTPNDCFEPVSPEFCGKE-- 479
F L+ +W GR + + E + + FE E G E
Sbjct: 958 WYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFE----ETRGMEEE 1013
Query: 480 ------AIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGL 533
+ + L K Y K ++ AL + ++YE Q+ + LGH+GAGKTT ++IL+GL
Sbjct: 1014 PTHLPLVVCVDKLTKVY--KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGL 1071
Query: 534 SVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHE 593
PTSGS T+Y H + +++ I K G CPQ NV F LTV+E+L ++++K + E
Sbjct: 1072 FPPTSGSATIYGHDIR--TEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEE 1129
Query: 594 VEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSR 653
+ +E+ +++++LE+ N + L Q LSGG RKL+ IA +G + ++LDEPTAG+DP +R
Sbjct: 1130 IRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYAR 1189
Query: 654 HRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHL 713
IW+L+ + K R IL ST +DEAD+L DR IS+GKLKC GS LFLK +G GY L
Sbjct: 1190 RAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRL 1249
Query: 714 SLHLN----------------------ERCDPESITSLVKQHISDAKLTAQSEEKLVYIL 751
+L C ++ +++H++ L + + +L YIL
Sbjct: 1250 TLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYIL 1309
Query: 752 PLERTNK--FPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKL-EGKSTIDESDIGI 804
P E K F L++ L+R + + +G+ TTL EVFLK+ E +++ S+ +
Sbjct: 1310 PSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADV 1366
Score = 228 bits (580), Expect = 5e-59
Identities = 132/368 (35%), Positives = 211/368 (57%), Gaps = 17/368 (4%)
Query: 1249 PNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIA 1308
P +P ++ D+ ER R + A D ++ L K Y +K + +A
Sbjct: 2052 PVSTKPVEDDVDVASERQRVLRGDADND-----MVKIENLTKVYKSRKIG------RILA 2100
Query: 1309 TRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPL----GFL 1364
+ V+ GE GLLG NGAGK++T KM+TGD T G+ + G + L L
Sbjct: 2101 VDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSL 2160
Query: 1365 GYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEG 1424
GYCPQ +AL+ LT R+HL++Y ++G+ D + ++ L+L P T S G
Sbjct: 2161 GYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGG 2220
Query: 1425 IKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEA 1484
KRKL ++++G P+ + LDEP+TGMDP+ ++ +W +I + T R +LT+H M E
Sbjct: 2221 NKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIK-TGRSVVLTSHSMEEC 2279
Query: 1485 EAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQ 1544
EA+C R+AIMV+GRLRC+GSIQHLK++FG Y++ ++ K+ ++ + R FP+A
Sbjct: 2280 EALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAML 2339
Query: 1545 QERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELG 1604
+ER + + Y+L E + L+Q F K+E V +E+YS+SQ+TL+ VF+ +K+Q
Sbjct: 2340 KERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2398
Query: 1605 DLEEDFDP 1612
+++ +P
Sbjct: 2399 LEQQETEP 2406
Score = 176 bits (446), Expect = 2e-43
Identities = 153/631 (24%), Positives = 291/631 (46%), Gaps = 63/631 (9%)
Query: 194 TNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFI--YYVSVNVTQERQY 251
TNH + + S++ L ++ QG TD I II +F+ +V V ++
Sbjct: 1801 TNHPMNKTSASLS------LDYLLQG---TDVVIAIFIIVAMSFVPASFVVFLVAEKSTK 1851
Query: 252 ITSLMTMMGLRESAFWLS---WGLMYAGFILIMATLMALIVKSAQIVVLTG---FVMVFT 305
L + G +WL+ W ++ L+ AT +I+ + T F V +
Sbjct: 1852 AKHLQFVSGCNPIIYWLANYVWDMLN---YLVPATCCVIILFVFDLPAYTSPTNFPAVLS 1908
Query: 306 LFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTR-----------L 354
LFLLYG S+ + + S + P + + ++ +F GI A + +
Sbjct: 1909 LFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVV 1968
Query: 355 PAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAHL---DSSQNPY---LIIATLFMLVF 408
++L+ + + G+ ++ + +Y A + D ++P+ ++ L +
Sbjct: 1969 NSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAV 2028
Query: 409 DTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCF 468
+ ++ +LT+ +Y P Q + +E++ D
Sbjct: 2029 EGVVGFLLTIM------CQYNFLRRP----------QRMPVSTKPVEDDVDVASER---- 2068
Query: 469 EPVSPEFCGKEAIRIKNLKKEYAG-KCERVEALKGVVFDIYEGQITALLGHSGAGKTTLL 527
+ V + ++I+NL K Y K R+ A+ + + G+ LLG +GAGKT+
Sbjct: 2069 QRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTF 2128
Query: 528 NILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIK 587
+L+G T G V H++ + ++ + + G+CPQ + F LT +E+L+L+ +++
Sbjct: 2129 KMLTGDESTTGGEAFVNGHSV--LKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLR 2186
Query: 588 GILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAG 647
GI + + V+ +++LE+ D A SGG RKL+ IA++G P + LDEPT G
Sbjct: 2187 GISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTG 2246
Query: 648 LDPLSRHRIWNLLKE-GKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKK 706
+DP +R +WNL+ + K+ R ++ ++ ++E + L R + NG+L+C GS LK +
Sbjct: 2247 MDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNR 2306
Query: 707 WGIGYHLSLHLNERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDL 766
+G GY +++ + + ++ +A L + K+ Y L E + +++ +
Sbjct: 2307 FGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHIS-LAQVFSKM 2365
Query: 767 DRCSN-QGIEDYGVSITTLNEVFLKLEGKST 796
++ S GIEDY VS TTL+ VF+ K +
Sbjct: 2366 EQVSGVLGIEDYSVSQTTLDNVFVNFAKKQS 2396
Score = 161 bits (408), Expect = 4e-39
Identities = 109/343 (31%), Positives = 173/343 (50%), Gaps = 31/343 (9%)
Query: 1302 KRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG----SGG 1357
K KK+A +S + + +V+ LGHNGAGK+TT+ ++TG PT+G + G +
Sbjct: 1031 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1090
Query: 1358 GEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAP 1417
E LG CPQ N L+ LTV +HL Y+ +K + + + + ++++ L+L ++ +
Sbjct: 1091 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSL 1150
Query: 1418 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLT 1477
V+TLS G+KRKL ++ +G ++LDEP+ G+DP ++ +W +I R LL+
Sbjct: 1151 VQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK--YKPGRTILLS 1208
Query: 1478 THYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILR 1537
TH+M EA+ + DR+AI+ G+L+C GS LK +G Y L + + P +
Sbjct: 1209 THHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLAS 1268
Query: 1538 LFPQAAQQERFSSLMV----------------------YKLPVEDVR--PLSQAFFKLEI 1573
P A S L V Y LP E + + F LE
Sbjct: 1269 SPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLER 1328
Query: 1574 VKQSFDLEEYSLSQSTLEQVFLELSKE-QELGDLEEDFDPSVK 1615
+ L + L +TLE+VFL++S+E Q L + E D S K
Sbjct: 1329 SLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRK 1371
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 287 bits (735), Expect = 5e-77
Identities = 239/825 (28%), Positives = 387/825 (46%), Gaps = 132/825 (16%)
Query: 177 GFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFST 236
GF Q + AII + T TGV+M+ +P+ D F+ S
Sbjct: 592 GFAYLQDVVEQAIIRVLTGTE------KKTGVYMQQMPYPCY---VDDIFLRVMSRSMPL 642
Query: 237 F-----IYYVSVNVT----QERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMAL 287
F IY V+V + ++ + M +MGL S W SW + +L+ A L+ +
Sbjct: 643 FMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVV 702
Query: 288 IVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLT----GLVVFLLIVFWG 343
I+K ++ + +VF ++ + I FL+S L + L G++ F L + +
Sbjct: 703 ILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPY- 761
Query: 344 ILGFPALYTRLPAFLEWTL----CLLSPFAFTVGMA-------QLIHLDYDVNSNAHLDS 392
L ++ +TL LLSP AF G Q I + +D + ++
Sbjct: 762 -----VLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVE- 815
Query: 393 SQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHV 452
++ + + ++ M++FDT LY V+T Y + + P +YG F +WF
Sbjct: 816 -EDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGE------ 868
Query: 453 VLENETDSDPTPNDCFEPVSPEFCGKE-------AIRIKNLKKEYAGKCERVEALKGVVF 505
E+D P + +S E C +E + I+NL K Y + A+ G+
Sbjct: 869 ----ESDEKSHPGSNQKRIS-EICMEEEPTHLKLGVSIQNLVKVYRDGMK--VAVDGLAL 921
Query: 506 DIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCP 565
+ YEGQIT+ LGH+GAGKTT ++IL+GL PTSG+ + + +++ I + G CP
Sbjct: 922 NFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIR--SEMSTIRQNLGVCP 979
Query: 566 QSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQ-DILAQNLSGGQNR 624
Q NV F LTV+E++ +A++KG+ V+ E++++ ++ + + + LSGG R
Sbjct: 980 QHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQR 1039
Query: 625 KLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILAD 684
KL+ +A +G +V++LDEPTAG+DP SR IW LL + + R I+ ST +DEAD+L D
Sbjct: 1040 KLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGD 1099
Query: 685 RKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNE------------------------- 719
R IS+GKL C GSSLFLK + G GY+L+L +
Sbjct: 1100 RIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVS 1159
Query: 720 -----------------RCDPESITSLVKQHISDAKLTAQSEEKLVYILPLE--RTNKFP 760
D +I++L+++H+S+A+L +L Y+LP E + F
Sbjct: 1160 QSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFV 1219
Query: 761 ELYRDL-DRCSNQGIEDYGVSITTLNEVFLKLEGKSTID-ESDIG---------IWGQLQ 809
EL+ ++ DR S+ GI YG+S TTL E+FLK+ +S +D E+ G +G Q
Sbjct: 1220 ELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQ 1279
Query: 810 T--------DGAKDIGSLVELE----QVLSSFH-ETRKTISGVALWRQQVCAIAKVRFLK 856
+ D A S ++ E +LS + + G L +QQ A+ R L
Sbjct: 1280 SCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLI 1339
Query: 857 LKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNTY 901
++ RK + ++L + L+ L + K EL P Y
Sbjct: 1340 ARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMY 1384
Score = 212 bits (539), Expect = 3e-54
Identities = 173/598 (28%), Positives = 287/598 (47%), Gaps = 57/598 (9%)
Query: 1034 ASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFS 1093
ASF ++ + K H Q ISG+ P YW + D+ Y + L+ I+ F
Sbjct: 1670 ASFVVFLIQERVS---KAKHLQF-ISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQ 1725
Query: 1094 PEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIFSIVA 1153
+ + NL + L + Y S+ L Y SF+F+ + + L + I VA
Sbjct: 1726 QKSYVSST-NLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVA 1784
Query: 1154 TDLNEY-------GFLGLFFGTMLIPPFTLIGSLFIF---SEISPDSMDYLGASES---- 1199
T + E + LI P +G I ++ D+++ G +
Sbjct: 1785 TFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPL 1844
Query: 1200 --EIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPV-FRISPRSNAIFPNPEEPEG 1256
++V L + ++F I ++ + +R PV ++SP ++
Sbjct: 1845 SWDLVGRNLFAMAVEGVVFFLITVLIQY---RFFIRPRPVNAKLSPLND----------- 1890
Query: 1257 EEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCV 1316
E+ED++ ER R ++ D E K+ +RK+K A + +
Sbjct: 1891 EDEDVRRERQRILDGGGQNDILEI--------------KELTKIYRRKRKPAVDRICVGI 1936
Query: 1317 KKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG----SGGGEPLGFLGYCPQENA 1372
GE GLLG NGAGKS+T KM+TGDT T G L S E +GYCPQ +A
Sbjct: 1937 PPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDA 1996
Query: 1373 LWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFV 1432
+ LT R+H+E +A ++G+ + + + L L + S G KRKL
Sbjct: 1997 ITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTA 2056
Query: 1433 LSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVA 1492
++++G P VV LDEP+TGMDP+ ++ +W + + R +LT+H M E EA+C R+A
Sbjct: 2057 MALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEG-RSVVLTSHSMEECEALCTRMA 2115
Query: 1493 IMVSGRLRCIGSIQHLKSKFGKDYLLEMKLK-NLAQMEPLHAEILRLFPQAAQQERFSSL 1551
IMV+GR RC+GS+QHLK++FG Y + +++ + ++P+ FP + +E+ ++
Sbjct: 2116 IMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNM 2175
Query: 1552 MVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDLEED 1609
+ Y+LP + L++ F L K+ +E+YS+SQ+TL+QVF+ +K+Q D +D
Sbjct: 2176 LQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKD 2232
Score = 158 bits (400), Expect = 4e-38
Identities = 160/651 (24%), Positives = 286/651 (43%), Gaps = 78/651 (11%)
Query: 177 GFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFST 236
G AF +N T + E + T V + + + F + F SF
Sbjct: 1628 GITAFNHPLNL------TKQQLSEVALMTTSVDVLV-------SICVIFAMSFVPASFVV 1674
Query: 237 FIYYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIV---KSAQ 293
F+ V+ + Q+I+ G++ +WLS + ++ ATL+ +I +
Sbjct: 1675 FLIQERVSKAKHLQFIS------GVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKS 1728
Query: 294 IVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTR 353
V T ++ L LLYG S+ L + S + K P +V+ + +F GI G A +
Sbjct: 1729 YVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFV- 1787
Query: 354 LPAFLEWTL-----CLLSPFA----FTVGMAQLIHLDYDVNSNAHLDSSQNPY------- 397
L F + L L S F F +G + + ++A +N +
Sbjct: 1788 LELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWD 1847
Query: 398 LIIATLFMLVFDTLLYLVLTL---YFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVL 454
L+ LF + + +++ ++T+ Y I P + SPL
Sbjct: 1848 LVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPL------------------- 1888
Query: 455 ENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITA 514
N+ D D + + + + IK L K Y K R A+ + I G+
Sbjct: 1889 -NDEDEDVRRER--QRILDGGGQNDILEIKELTKIYRRK--RKPAVDRICVGIPPGECFG 1943
Query: 515 LLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFL 574
LLG +GAGK++ +L+G + T G + +++ +++I + + G+CPQ + L
Sbjct: 1944 LLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSI--LSNIHEVHQNMGYCPQFDAITELL 2001
Query: 575 TVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILG 634
T +E++ FA ++G+ EV K + +++L + + A N SGG RKL+ +A++G
Sbjct: 2002 TGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIG 2061
Query: 635 DPQVLLLDEPTAGLDPLSRHRIWN----LLKEGKSDRVILFSTQFIDEADILADRKVFIS 690
P V+ LDEPT G+DP +R +WN ++KEG+S ++ ++ ++E + L R +
Sbjct: 2062 GPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRS---VVLTSHSMEECEALCTRMAIMV 2118
Query: 691 NGKLKCAGSSLFLKKKWGIGYHLSLHL-NERCDPESITSLVKQHISDAKLTAQSEEKLVY 749
NG+ +C GS LK ++G GY + + + D + + + L + L Y
Sbjct: 2119 NGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQY 2178
Query: 750 ILPLERTNKFPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKLEGKSTIDE 799
LP + ++ L + + IEDY VS TTL++VF+ + D+
Sbjct: 2179 QLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDD 2228
Score = 142 bits (359), Expect = 2e-33
Identities = 95/344 (27%), Positives = 167/344 (48%), Gaps = 51/344 (14%)
Query: 1306 KIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGF-- 1363
K+A ++ +G++ LGHNGAGK+TT+ ++TG PT+G + G +
Sbjct: 913 KVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIR 972
Query: 1364 --LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRL-VDALKLQDQLKAPVKT 1420
LG CPQ N L+ LTV +H+ YA +KGL + + ++ +D +LK+
Sbjct: 973 QNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQ 1032
Query: 1421 LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHY 1480
LS G++RKL L+ +G VV+LDEP+ G+DP ++ +W+++ +R R +L+TH+
Sbjct: 1033 LSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELL-LKYRQ-GRTIILSTHH 1090
Query: 1481 MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNL--------------- 1525
M EA+ + DR+AI+ G+L C+GS LK++ G Y L + K++
Sbjct: 1091 MDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVS 1150
Query: 1526 ---------------------------AQMEPLHAEILRLFPQAAQQERFSSLMVYKLPV 1558
+ + I + +A E + Y LP
Sbjct: 1151 YLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPY 1210
Query: 1559 EDVR--PLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKE 1600
E + + F +++ + Y +S++TLE++FL++++E
Sbjct: 1211 EAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEE 1254
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 280 bits (717), Expect = 6e-75
Identities = 228/804 (28%), Positives = 366/804 (45%), Gaps = 108/804 (13%)
Query: 177 GFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFST 236
GFV Q + A + + + + G++++ +P+ D F+ S
Sbjct: 502 GFVYLQDLVERAAVRVLSGANPR------AGLYLQQMPYPCY---VDDVFLRVLSRSLPL 552
Query: 237 F-----IYYVSVNVT----QERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMAL 287
F IY V++ V ++ + M MGL + WL W L G L+ A L+ L
Sbjct: 553 FLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVL 612
Query: 288 IVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLT----GLVVFLLIVFWG 343
++K I+ + +VF + ++ +T +FL+S + L GL F L + +
Sbjct: 613 VLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYV 672
Query: 344 ILGFPALYTRLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATL 403
+ A RLPA LLSP AF G L L+ + P + +L
Sbjct: 673 LC--VAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSL 730
Query: 404 F----MLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETD 459
+L+ D LY + T Y + + P +YG F + +W
Sbjct: 731 AQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYW----------CGPRPP 780
Query: 460 SDPTPNDCFEPVSPEFCGKEA-------IRIKNLKKEYAGKCERVEALKGVVFDIYEGQI 512
P P C P+ P+ +EA + +++L+K + G + AL+G+ D Y+G I
Sbjct: 781 KSPAP--CPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQ--PALRGLSLDFYQGHI 836
Query: 513 TALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFG 572
TA LGH+GAGKTT L+ILSGL P+ GS + H + + + I G CPQ NV F
Sbjct: 837 TAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVR--SSMAAIRPHLGVCPQYNVLFD 894
Query: 573 FLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAI 632
LTV E++ + ++KG+ V E R++Q++ + + Q + ++LSGG RKL+ IA
Sbjct: 895 MLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAF 954
Query: 633 LGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNG 692
+G QV++LDEPTAG+DP SR IW LL + + R ++ ST +DEA++L DR ++ G
Sbjct: 955 VGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGG 1014
Query: 693 KLKCAGSSLFLKKKWGIGYHLS-------LHLNERCDPE--------------------- 724
+L C GS LFL++ G GY+L+ L NE+ D +
Sbjct: 1015 RLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVG 1074
Query: 725 --SITSLVKQHISDAKLTAQSEEKLVYILPL--ERTNKFPELYRDLD-RCSNQGIEDYGV 779
+ +LV+ + A+L + +LV +LP F L+R+LD R + + YG+
Sbjct: 1075 TPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGI 1134
Query: 780 SITTLNEVFLKLEGKSTID-ESDIGIWGQ---------------------LQTDGAKDIG 817
S T+L E+FLK+ + D + + G GQ + + G
Sbjct: 1135 SDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAG 1194
Query: 818 SLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIP 877
S E +Q S + + G AL RQQ+ A+ RFL ++ R+ L+ ++L +
Sbjct: 1195 SAPETDQ--GSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGL 1252
Query: 878 QLLEHLFYESYQKSYPWELSPNTY 901
L+ L + LSP Y
Sbjct: 1253 ALVFSLIVPPFGHYPALRLSPTMY 1276
Score = 217 bits (552), Expect = 8e-56
Identities = 182/593 (30%), Positives = 283/593 (47%), Gaps = 64/593 (10%)
Query: 1034 ASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFS 1093
ASFT + + K H QL + GL P+ YW G L D+ Y L+ + ++ ++
Sbjct: 1551 ASFTLVLIEERVTRAK---HLQL-MGGLSPTLYWLGNFLWDMCNY-LVPACIVVLIFLAF 1605
Query: 1094 PEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIFSIVA 1153
+ NL +L + Y S+ L Y SF F + + L + I +A
Sbjct: 1606 QQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMA 1665
Query: 1154 TDLNEY----------GFLGLFFGTMLIPPFTLIGSLF--IFSEISPDSMDYLGASES-- 1199
T + E L F ++ P F L L + ++ D+ + LG +
Sbjct: 1666 TFVLELFSDQKLQEVSRILKQVF--LIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQS 1723
Query: 1200 ----EIV---YLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPE 1252
E+V LA++I FL+F +L+ + + P R P
Sbjct: 1724 PLRWEVVGKNLLAMVIQGPLFLLFTLLLQ------HRSQLLPQPRVRSLPLLGE------ 1771
Query: 1253 EPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNV 1312
E+ED+ ER R V D V++ L K Y G++ A +
Sbjct: 1772 ----EDEDVARERERVVQGATQGD-----VLVLRNLTKVYRGQRMP---------AVDRL 1813
Query: 1313 SFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG-SGGGEPLGF---LGYCP 1368
+ GE GLLG NGAGK++T +M+TGDT + G+ +L G S EP +GYCP
Sbjct: 1814 CLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCP 1873
Query: 1369 QENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRK 1428
Q +A++ LT R+HLE+ A ++G+ + + L L P T S G KRK
Sbjct: 1874 QSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRK 1933
Query: 1429 LCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVC 1488
L L+++G+P+VV LDEP+TGMDP ++ +W + A R R +LT+H M E EA+C
Sbjct: 1934 LATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREG-RSVMLTSHSMEECEALC 1992
Query: 1489 DRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERF 1548
R+AIMV+GR RC+GS QHLK +F + L +++ A+ +P A + FP A +E
Sbjct: 1993 SRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVP-AARSQPAAAFVAAEFPGAELREAH 2051
Query: 1549 SSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQ 1601
+ ++LP L++ F +L + +E++S+SQ+ LE+VFL SK+Q
Sbjct: 2052 GGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQ 2104
Score = 167 bits (423), Expect = 8e-41
Identities = 154/610 (25%), Positives = 266/610 (43%), Gaps = 51/610 (8%)
Query: 222 ATDFFIFFCIISFSTFI--YYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFIL 279
+ D + C++ +F+ + V + + L M GL + +WL L L
Sbjct: 1533 SVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYL 1592
Query: 280 IMATLMALIVKSAQ---IVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVF 336
+ A ++ LI + Q V + L LLYG S+ L + S P +V+
Sbjct: 1593 VPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLT 1652
Query: 337 LLIVFWGILGFPALYT----------RLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNS 386
+ +F GI G A + + L+ + F G+ ++ ++
Sbjct: 1653 CINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADA 1712
Query: 387 NAHLDSSQ--NPY---LIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSC 441
L Q +P ++ L +V L+L+ TL HR L
Sbjct: 1713 FERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQ--------HRSQLL------ 1758
Query: 442 FWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEYAGKCERVEALK 501
R + L E D D E V + + ++NL K Y G +R+ A+
Sbjct: 1759 ---PQPRVRSLPLLGEEDEDVARER--ERVVQGATQGDVLVLRNLTKVYRG--QRMPAVD 1811
Query: 502 GVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFT 561
+ I G+ LLG +GAGKT+ +++G ++ + G + H+++R ++S
Sbjct: 1812 RLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSM-- 1869
Query: 562 GFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGG 621
G+CPQS+ F LT +E+L L A+++G+ +V + + L + D A SGG
Sbjct: 1870 GYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGG 1929
Query: 622 QNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWN-LLKEGKSDRVILFSTQFIDEAD 680
RKL +A++GDP V+ LDEPT G+DP +R +WN LL + R ++ ++ ++E +
Sbjct: 1930 NKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECE 1989
Query: 681 ILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPESITSLVKQHISDAKLT 740
L R + NG+ +C GS LK ++ G+ L+L + + + V A+L
Sbjct: 1990 ALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRV-PAARSQPAAAFVAAEFPGAELR 2048
Query: 741 AQSEEKLVYILPLERTNKFPELYRDLD-RCSNQGIEDYGVSITTLNEVFL---KLEGK-- 794
+L + LP ++ +L + G+ED+ VS T L EVFL K +GK
Sbjct: 2049 EAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDE 2108
Query: 795 STIDESDIGI 804
T ++ + G+
Sbjct: 2109 DTEEQKEAGV 2118
Score = 133 bits (334), Expect = 2e-30
Identities = 98/329 (29%), Positives = 155/329 (47%), Gaps = 38/329 (11%)
Query: 1308 ATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLG----F 1363
A R +S +G + LGHNGAGK+TT+ +++G P+ G + G +
Sbjct: 823 ALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPH 882
Query: 1364 LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSE 1423
LG CPQ N L+ LTV +H+ Y +KGL RL+ + L + + LS
Sbjct: 883 LGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSG 942
Query: 1424 GIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAE 1483
G++RKL ++ +G VV+LDEP+ G+DP ++ +W+++ +R R +L+TH++ E
Sbjct: 943 GMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELL-LKYRE-GRTLILSTHHLDE 1000
Query: 1484 AEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM----------------------- 1520
AE + DRVA++ GRL C GS L+ G Y L +
Sbjct: 1001 AELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDT 1060
Query: 1521 --KLKNLAQ-----MEPLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQA--FFKL 1571
+ KN +Q L A + P A E +V LP S A F +L
Sbjct: 1061 RQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFREL 1120
Query: 1572 EIVKQSFDLEEYSLSQSTLEQVFLELSKE 1600
+ L Y +S ++LE++FL++ +E
Sbjct: 1121 DTRLAELRLTGYGISDTSLEEIFLKVVEE 1149
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 268 bits (686), Expect = 2e-71
Identities = 209/786 (26%), Positives = 379/786 (48%), Gaps = 70/786 (8%)
Query: 171 SEFWEKGFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFC 230
++ + + F+ Q +I AIIE+ T + E + V + P + T
Sbjct: 696 NQIYGRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPY---PCFMKDNFLTSVSYSLP 752
Query: 231 IISFSTFIYYVSVNVT----QERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMA 286
I+ ++ +++ V ++ + M MMG+ + + +W + GF+L+ ++
Sbjct: 753 IVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILI 812
Query: 287 LIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLV--VFLLIVFWGI 344
+I+K I+ T ++F F Y S+I +++L+SV + L+ + +I F+
Sbjct: 813 IILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPF 872
Query: 345 LGFPALYTRLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLF 404
+ + L L+ + LLSP AF+ + + + +P T F
Sbjct: 873 IVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSF 932
Query: 405 -----MLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQH--------GRANH 451
+++ D+ +Y ++ Y + P YG F + +W + ++N
Sbjct: 933 GWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNG 992
Query: 452 VVLEN----ETDSDPTPNDCFEP-VSPEFCGKE---AIRIKNLKKEYAGKCERVEALKGV 503
++ N T+ +P F + PE K+ + + + K Y K A+ +
Sbjct: 993 LMFTNIMMQNTNPSASPEYMFSSNIEPE--PKDLTVGVALHGVTKIYGSKV----AVDNL 1046
Query: 504 VFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGF 563
+ YEG IT+LLG +GAGKTT +++L+GL ++G++ VY + D+ + K G
Sbjct: 1047 NLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK--TDLHTVRKNMGV 1104
Query: 564 CPQSNVQFGFLTVKENLRLFAKIKGILPH----EVEKEVQRVVQELEMENIQDILAQNLS 619
C Q +V F +LT KE+L L+ IK +PH ++ +EV+R +++ + + + LS
Sbjct: 1105 CMQHDVLFSYLTTKEHLLLYGSIK--VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLS 1162
Query: 620 GGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEA 679
GG RKL+ IA++G +V++LDEP+ G+DP SR IW+++ + K+ R I+ ST +DEA
Sbjct: 1163 GGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEA 1222
Query: 680 DILADRKVFISNGKLKCAGSSLFLKKKWGIGYHL--------SLHLNERCDPESITSLVK 731
++L+DR F+ G L+C GS +LK+ +G GYHL +L+ N CD ++T++++
Sbjct: 1223 EVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQ 1282
Query: 732 QHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIED-----YGVSITTLNE 786
H+ +A L +LVY+LP T K Y L R + G+ D YG+S TT+ E
Sbjct: 1283 SHLPEAYLKEDIGGELVYVLPPFST-KVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEE 1341
Query: 787 VFLKLEGKSTIDES---DIGIWGQLQTDGAKDIGSLVELEQVLSSFHE------TR-KTI 836
VFL L +S + + + ++ A I + +L S+F + TR + +
Sbjct: 1342 VFLNLTKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERL 1401
Query: 837 SGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYP-WE 895
G L +++ AI RF ++ K L ++L I F+ + + SYP +
Sbjct: 1402 DGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVIL-PIVFVTTAMGLGTLRNSSNSYPEIQ 1460
Query: 896 LSPNTY 901
+SP+ Y
Sbjct: 1461 ISPSLY 1466
Score = 233 bits (595), Expect = 9e-61
Identities = 182/599 (30%), Positives = 297/599 (49%), Gaps = 60/599 (10%)
Query: 1034 ASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLY-----FLILLLMQIM 1088
ASF Y+ + +++ KA ISG+ + YW + D+ Y F I ++
Sbjct: 1684 ASFVTYV----VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFK 1739
Query: 1089 DYIFSPEEIIFIIQNLLI----------QILCSIGYVSSLVFLTYVISFIFRNGRKNSGI 1138
F E + + LL+ +L + + + + F+TYV +F GI
Sbjct: 1740 LPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLF------FGI 1793
Query: 1139 WSFFFLIVVIFSIVATDLNEYGFLGLFFGTM----LIPPFTLIGSLFIFSEISPDSMDYL 1194
S L VV F ++ + L L T+ LI P G I +D+L
Sbjct: 1794 NSIVSLSVVYF--LSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFL 1851
Query: 1195 GASESEIVYLALLIPYLHFLIFLFILR-----CLEMNCRKKLMRKDPVFRISPRSNAIFP 1249
A E + L + + + L + + L++K +F S+ +
Sbjct: 1852 KAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHV-- 1909
Query: 1250 NPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIAT 1309
E E+ED++ ER+R + A +FD ++ CL K Y KK IA
Sbjct: 1910 --RETIDEDEDVRAERLRVESGAA--EFD---LVQLYCLTKTYQ-------LIHKKIIAV 1955
Query: 1310 RNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGG-----EPLGFL 1364
N+S + GE GLLG NGAGK+T KM+TGD P++G ++++ G +
Sbjct: 1956 NNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLV 2015
Query: 1365 GYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEG 1424
GYCPQE+AL +TV +HL YA V G+ + D + +L+ L L S G
Sbjct: 2016 GYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYG 2075
Query: 1425 IKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEA 1484
KRKL L+++G PS++LLDEPS+GMDP+ ++ +W++I +N + +LT+H M E
Sbjct: 2076 TKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN-KCSVILTSHSMEEC 2134
Query: 1485 EAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLK-NLAQMEPLHAEILRLFPQAA 1543
EA+C R+AIMV+G+ +CIGS+QH+KS+FG+ + +++ LK N ME L + FP+
Sbjct: 2135 EALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTY 2194
Query: 1544 QQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQE 1602
+++ S++ Y +PV ++ F LE K + ++ + +SQ+TLE+VF+ +K+Q+
Sbjct: 2195 LKDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQK 2252
Score = 162 bits (409), Expect = 3e-39
Identities = 139/598 (23%), Positives = 272/598 (45%), Gaps = 52/598 (8%)
Query: 221 VATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILI 280
VA + + + + S Y V + T+ +Q L + G+ + +W++ + F L+
Sbjct: 1671 VALSILMGYSVTTASFVTYVVREHQTKAKQ----LQHISGIGVTCYWVTNFIYDMVFYLV 1726
Query: 281 MATLMALIVKSAQIVVL---TGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFL 337
I+ ++ V L LL+G + + +L++ L + + +
Sbjct: 1727 PVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVC 1786
Query: 338 LIVFWGILGFPALYT---------------RLPAFLEWTLCLLSPFAFTVGMAQLIH--- 379
+ +F+GI +L + L+ + F F G+ +L
Sbjct: 1787 VNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQS 1846
Query: 380 -LDYDVNSNAHLDSSQNPYLIIATLFM-LVFDTLLYLVLTLYFDKILPAEYGHRCSPLFF 437
LD+ + + +F+ LV ++ L L ++ L
Sbjct: 1847 VLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESL------------I 1894
Query: 438 LKSCFWFQHGRANHVVLENETDSDPTPNDC-FEPVSPEFCGKEAIRIKNLKKEYAGKCER 496
K +F+ ++HV + D D E + EF + +++ L K Y ++
Sbjct: 1895 KKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGAAEF---DLVQLYCLTKTYQLIHKK 1951
Query: 497 VEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIEN 556
+ A+ + I G+ LLG +GAGKTT+ +L+G +P+SG++ + N T S + +++
Sbjct: 1952 IIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGS-LGHVDS 2010
Query: 557 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQ 616
S G+CPQ + +TV+E+L +A++ GI ++++ V ++++ L + +D
Sbjct: 2011 HSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATS 2070
Query: 617 NLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRV-ILFSTQF 675
S G RKL+ +A++G P +LLLDEP++G+DP S+ +W ++ E ++ ++ ++
Sbjct: 2071 MCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHS 2130
Query: 676 IDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHL-NERCDPESITSLVKQHI 734
++E + L R + NGK +C GS +K ++G G+ + +HL N + E++T ++ H
Sbjct: 2131 MEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHF 2190
Query: 735 SDAKLTAQSEEKLVYILPLER---TNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFL 789
L Q L Y +P+ N F L + + I ++ VS TTL EVF+
Sbjct: 2191 PKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALN---ITNFLVSQTTLEEVFI 2245
Score = 155 bits (391), Expect = 4e-37
Identities = 162/622 (26%), Positives = 268/622 (43%), Gaps = 77/622 (12%)
Query: 1029 WIPMAASFTPYIAMSSIGDYKK--KAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQ 1086
W+ A+F + Y+K + H +++ G+ +++F + V + L+ +++
Sbjct: 759 WVVFIAAFVKKLV------YEKDLRLHEYMKMMGVNSCSHFFAWLIESVG-FLLVTIVIL 811
Query: 1087 IMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIV 1146
I+ F I N I L Y S++ ++Y+IS F N + I S ++I
Sbjct: 812 IIILKFGN---ILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIA 868
Query: 1147 VI-FSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFI-----------FSEISPDSMDYL 1194
F ++ T NE ++ F ++L P S +I + + +
Sbjct: 869 FFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDD 928
Query: 1195 GASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISP-----RSNAIFP 1249
S + L L +++FLI ++ M F I P R
Sbjct: 929 TTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYG---MAAPWYFPILPSYWKERFGCAEV 985
Query: 1250 NPEEPEGEEEDIQMERMRTVNAMAVRDF-----------DETPVIIASCLRKEYAGKKKN 1298
PE+ G M M+ N A ++ D T + + K Y K
Sbjct: 986 KPEKSNGLMFTNIM--MQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSK--- 1040
Query: 1299 CFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGG 1358
+A N++ +G + LLG NGAGK+TTI M+TG +AG + + G
Sbjct: 1041 --------VAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK 1092
Query: 1359 EPLGF----LGYCPQENALWPNLTVRQHLEVYAAVK--GLRKGDAMIAITRLVDALKLQD 1412
L +G C Q + L+ LT ++HL +Y ++K K + R + L
Sbjct: 1093 TDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYS 1152
Query: 1413 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTER 1472
V TLS G+KRKL ++++G VV+LDEPSTG+DP ++ +W VI + T R
Sbjct: 1153 HRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVI--SKNKTAR 1210
Query: 1473 GALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQME--- 1529
+L+TH++ EAE + DR+A + G LRC GS +LK FG Y L + K +
Sbjct: 1211 TIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANA 1270
Query: 1530 -----PLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFK----LEIVKQSFDL 1580
+ A I P+A +E +VY LP + +S A+ L+ ++
Sbjct: 1271 VCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTK-VSGAYLSLLRALDNGMGDLNI 1329
Query: 1581 EEYSLSQSTLEQVFLELSKEQE 1602
Y +S +T+E+VFL L+KE +
Sbjct: 1330 GCYGISDTTVEEVFLNLTKESQ 1351
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 268 bits (686), Expect = 2e-71
Identities = 209/786 (26%), Positives = 379/786 (48%), Gaps = 70/786 (8%)
Query: 171 SEFWEKGFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFC 230
++ + + F+ Q +I AIIE+ T + E + V + P + T
Sbjct: 1014 NQIYGRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPY---PCFMKDNFLTSVSYSLP 1070
Query: 231 IISFSTFIYYVSVNVT----QERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMA 286
I+ ++ +++ V ++ + M MMG+ + + +W + GF+L+ ++
Sbjct: 1071 IVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILI 1130
Query: 287 LIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLV--VFLLIVFWGI 344
+I+K I+ T ++F F Y S+I +++L+SV + L+ + +I F+
Sbjct: 1131 IILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPF 1190
Query: 345 LGFPALYTRLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLF 404
+ + L L+ + LLSP AF+ + + + +P T F
Sbjct: 1191 IVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSF 1250
Query: 405 -----MLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQH--------GRANH 451
+++ D+ +Y ++ Y + P YG F + +W + ++N
Sbjct: 1251 GWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNG 1310
Query: 452 VVLEN----ETDSDPTPNDCFEP-VSPEFCGKE---AIRIKNLKKEYAGKCERVEALKGV 503
++ N T+ +P F + PE K+ + + + K Y K A+ +
Sbjct: 1311 LMFTNIMMQNTNPSASPEYMFSSNIEPE--PKDLTVGVALHGVTKIYGSKV----AVDNL 1364
Query: 504 VFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGF 563
+ YEG IT+LLG +GAGKTT +++L+GL ++G++ VY + D+ + K G
Sbjct: 1365 NLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK--TDLHTVRKNMGV 1422
Query: 564 CPQSNVQFGFLTVKENLRLFAKIKGILPH----EVEKEVQRVVQELEMENIQDILAQNLS 619
C Q +V F +LT KE+L L+ IK +PH ++ +EV+R +++ + + + LS
Sbjct: 1423 CMQHDVLFSYLTTKEHLLLYGSIK--VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLS 1480
Query: 620 GGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEA 679
GG RKL+ IA++G +V++LDEP+ G+DP SR IW+++ + K+ R I+ ST +DEA
Sbjct: 1481 GGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEA 1540
Query: 680 DILADRKVFISNGKLKCAGSSLFLKKKWGIGYHL--------SLHLNERCDPESITSLVK 731
++L+DR F+ G L+C GS +LK+ +G GYHL +L+ N CD ++T++++
Sbjct: 1541 EVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQ 1600
Query: 732 QHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIED-----YGVSITTLNE 786
H+ +A L +LVY+LP T K Y L R + G+ D YG+S TT+ E
Sbjct: 1601 SHLPEAYLKEDIGGELVYVLPPFST-KVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEE 1659
Query: 787 VFLKLEGKSTIDES---DIGIWGQLQTDGAKDIGSLVELEQVLSSFHE------TR-KTI 836
VFL L +S + + + ++ A I + +L S+F + TR + +
Sbjct: 1660 VFLNLTKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERL 1719
Query: 837 SGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYP-WE 895
G L +++ AI RF ++ K L ++L I F+ + + SYP +
Sbjct: 1720 DGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVIL-PIVFVTTAMGLGTLRNSSNSYPEIQ 1778
Query: 896 LSPNTY 901
+SP+ Y
Sbjct: 1779 ISPSLY 1784
Score = 233 bits (595), Expect = 9e-61
Identities = 182/599 (30%), Positives = 297/599 (49%), Gaps = 60/599 (10%)
Query: 1034 ASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLY-----FLILLLMQIM 1088
ASF Y+ + +++ KA ISG+ + YW + D+ Y F I ++
Sbjct: 2002 ASFVTYV----VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFK 2057
Query: 1089 DYIFSPEEIIFIIQNLLI----------QILCSIGYVSSLVFLTYVISFIFRNGRKNSGI 1138
F E + + LL+ +L + + + + F+TYV +F GI
Sbjct: 2058 LPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLF------FGI 2111
Query: 1139 WSFFFLIVVIFSIVATDLNEYGFLGLFFGTM----LIPPFTLIGSLFIFSEISPDSMDYL 1194
S L VV F ++ + L L T+ LI P G I +D+L
Sbjct: 2112 NSIVSLSVVYF--LSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFL 2169
Query: 1195 GASESEIVYLALLIPYLHFLIFLFILR-----CLEMNCRKKLMRKDPVFRISPRSNAIFP 1249
A E + L + + + L + + L++K +F S+ +
Sbjct: 2170 KAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHV-- 2227
Query: 1250 NPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIAT 1309
E E+ED++ ER+R + A +FD ++ CL K Y KK IA
Sbjct: 2228 --RETIDEDEDVRAERLRVESGAA--EFD---LVQLYCLTKTYQ-------LIHKKIIAV 2273
Query: 1310 RNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGG-----EPLGFL 1364
N+S + GE GLLG NGAGK+T KM+TGD P++G ++++ G +
Sbjct: 2274 NNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLV 2333
Query: 1365 GYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEG 1424
GYCPQE+AL +TV +HL YA V G+ + D + +L+ L L S G
Sbjct: 2334 GYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYG 2393
Query: 1425 IKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEA 1484
KRKL L+++G PS++LLDEPS+GMDP+ ++ +W++I +N + +LT+H M E
Sbjct: 2394 TKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN-KCSVILTSHSMEEC 2452
Query: 1485 EAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLK-NLAQMEPLHAEILRLFPQAA 1543
EA+C R+AIMV+G+ +CIGS+QH+KS+FG+ + +++ LK N ME L + FP+
Sbjct: 2453 EALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTY 2512
Query: 1544 QQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQE 1602
+++ S++ Y +PV ++ F LE K + ++ + +SQ+TLE+VF+ +K+Q+
Sbjct: 2513 LKDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQK 2570
Score = 162 bits (409), Expect = 3e-39
Identities = 139/598 (23%), Positives = 272/598 (45%), Gaps = 52/598 (8%)
Query: 221 VATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILI 280
VA + + + + S Y V + T+ +Q L + G+ + +W++ + F L+
Sbjct: 1989 VALSILMGYSVTTASFVTYVVREHQTKAKQ----LQHISGIGVTCYWVTNFIYDMVFYLV 2044
Query: 281 MATLMALIVKSAQIVVL---TGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFL 337
I+ ++ V L LL+G + + +L++ L + + +
Sbjct: 2045 PVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVC 2104
Query: 338 LIVFWGILGFPALYT---------------RLPAFLEWTLCLLSPFAFTVGMAQLIH--- 379
+ +F+GI +L + L+ + F F G+ +L
Sbjct: 2105 VNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQS 2164
Query: 380 -LDYDVNSNAHLDSSQNPYLIIATLFM-LVFDTLLYLVLTLYFDKILPAEYGHRCSPLFF 437
LD+ + + +F+ LV ++ L L ++ L
Sbjct: 2165 VLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESL------------I 2212
Query: 438 LKSCFWFQHGRANHVVLENETDSDPTPNDC-FEPVSPEFCGKEAIRIKNLKKEYAGKCER 496
K +F+ ++HV + D D E + EF + +++ L K Y ++
Sbjct: 2213 KKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGAAEF---DLVQLYCLTKTYQLIHKK 2269
Query: 497 VEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIEN 556
+ A+ + I G+ LLG +GAGKTT+ +L+G +P+SG++ + N T S + +++
Sbjct: 2270 IIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGS-LGHVDS 2328
Query: 557 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQ 616
S G+CPQ + +TV+E+L +A++ GI ++++ V ++++ L + +D
Sbjct: 2329 HSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATS 2388
Query: 617 NLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRV-ILFSTQF 675
S G RKL+ +A++G P +LLLDEP++G+DP S+ +W ++ E ++ ++ ++
Sbjct: 2389 MCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHS 2448
Query: 676 IDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHL-NERCDPESITSLVKQHI 734
++E + L R + NGK +C GS +K ++G G+ + +HL N + E++T ++ H
Sbjct: 2449 MEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHF 2508
Query: 735 SDAKLTAQSEEKLVYILPLER---TNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFL 789
L Q L Y +P+ N F L + + I ++ VS TTL EVF+
Sbjct: 2509 PKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALN---ITNFLVSQTTLEEVFI 2563
Score = 155 bits (391), Expect = 4e-37
Identities = 162/622 (26%), Positives = 268/622 (43%), Gaps = 77/622 (12%)
Query: 1029 WIPMAASFTPYIAMSSIGDYKK--KAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQ 1086
W+ A+F + Y+K + H +++ G+ +++F + V + L+ +++
Sbjct: 1077 WVVFIAAFVKKLV------YEKDLRLHEYMKMMGVNSCSHFFAWLIESVG-FLLVTIVIL 1129
Query: 1087 IMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIV 1146
I+ F I N I L Y S++ ++Y+IS F N + I S ++I
Sbjct: 1130 IIILKFGN---ILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIA 1186
Query: 1147 VI-FSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFI-----------FSEISPDSMDYL 1194
F ++ T NE ++ F ++L P S +I + + +
Sbjct: 1187 FFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDD 1246
Query: 1195 GASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISP-----RSNAIFP 1249
S + L L +++FLI ++ M F I P R
Sbjct: 1247 TTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYG---MAAPWYFPILPSYWKERFGCAEV 1303
Query: 1250 NPEEPEGEEEDIQMERMRTVNAMAVRDF-----------DETPVIIASCLRKEYAGKKKN 1298
PE+ G M M+ N A ++ D T + + K Y K
Sbjct: 1304 KPEKSNGLMFTNIM--MQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSK--- 1358
Query: 1299 CFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGG 1358
+A N++ +G + LLG NGAGK+TTI M+TG +AG + + G
Sbjct: 1359 --------VAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK 1410
Query: 1359 EPLGF----LGYCPQENALWPNLTVRQHLEVYAAVK--GLRKGDAMIAITRLVDALKLQD 1412
L +G C Q + L+ LT ++HL +Y ++K K + R + L
Sbjct: 1411 TDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYS 1470
Query: 1413 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTER 1472
V TLS G+KRKL ++++G VV+LDEPSTG+DP ++ +W VI + T R
Sbjct: 1471 HRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVI--SKNKTAR 1528
Query: 1473 GALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQME--- 1529
+L+TH++ EAE + DR+A + G LRC GS +LK FG Y L + K +
Sbjct: 1529 TIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANA 1588
Query: 1530 -----PLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFK----LEIVKQSFDL 1580
+ A I P+A +E +VY LP + +S A+ L+ ++
Sbjct: 1589 VCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTK-VSGAYLSLLRALDNGMGDLNI 1647
Query: 1581 EEYSLSQSTLEQVFLELSKEQE 1602
Y +S +T+E+VFL L+KE +
Sbjct: 1648 GCYGISDTTVEEVFLNLTKESQ 1669
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 261 bits (666), Expect = 5e-69
Identities = 225/783 (28%), Positives = 365/783 (46%), Gaps = 63/783 (8%)
Query: 178 FVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFI-----FFCII 232
F Q I AII + T +E + P+ +D F+ FF +I
Sbjct: 3524 FAPLQDMIERAIILVQTGQEALEP-----AAQTQAAPYPCH---TSDLFLNNVGFFFPLI 3575
Query: 233 SFSTFIYYVSVNVT----QERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALI 288
T++ V+ V ++ I M MMG+ +L+W L + I + +A++
Sbjct: 3576 MMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIV 3635
Query: 289 VKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFL--LIVFWGILG 346
+K++ I + +VF L +G+S++ L++L+S + L L +I F +
Sbjct: 3636 LKTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIV 3695
Query: 347 FPALYTRLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVN----SNAHLDSSQNPYLIIAT 402
L+ +L + LCLLS AF G+ + L+ +N + Q
Sbjct: 3696 LLVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWV 3755
Query: 403 LFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDP 462
+M++FD+ LY + Y ++P +G R F + +W G + S
Sbjct: 3756 CWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLF 3815
Query: 463 TPNDCFEPVSPEFCGKEA--------IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITA 514
N+ F+ +E + + ++ KEY G V+ L Y QITA
Sbjct: 3816 FFNENFDNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKAVVQDLS---LTFYRDQITA 3872
Query: 515 LLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFL 574
LLG +GAGKTT++++L+GL PTSG++ + L D+ + G CPQ ++ L
Sbjct: 3873 LLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQ--TDLSRVRMELGVCPQQDILLDNL 3930
Query: 575 TVKENLRLFAKIKGI--LPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAI 632
TV+E+L LFA IK E+ ++V + +Q++++ Q + LSGG RKL+ GIA
Sbjct: 3931 TVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAF 3990
Query: 633 LGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNG 692
+G + ++LDEPT+G+DP SRH +W++L + + R I+F+T +DEA+ L+DR + +G
Sbjct: 3991 MGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHG 4050
Query: 693 KLKCAGSSLFLKKKWGIGYHLS-------LHLNERCDPESITSLVKQHISDAKLTAQSEE 745
+L+C G LK+ +G G L+ L ++ D +TSL+K +I A L S
Sbjct: 4051 RLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSSGS 4110
Query: 746 KLVYILPLERTNK--FPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKLEGKSTIDESDI 802
+L Y +P + T+K L++ LD +Q + YG+S TTL EVFL L S +S I
Sbjct: 4111 ELTYTIPKD-TDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQDSN-KKSHI 4168
Query: 803 GIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERK 862
+ + + + G L L+ T+ GV L R QV AI R + + K
Sbjct: 4169 ALGTESELQNHRPTGHLSGYCGSLA----RPATVQGVQLLRAQVAAILARRLRRTLRAGK 4224
Query: 863 SLWTILLLFGISFIPQLLEHLFYESYQKSY-PWELSP------NTYFLSPGQQPQDPLTH 915
S LLL + F+ + Y P L+P TYF S G D LT
Sbjct: 4225 STLADLLL-PVLFVALAMGLFMVRPLATEYPPLRLTPGHYQRAETYFFSSGGDNLD-LTR 4282
Query: 916 LLV 918
+L+
Sbjct: 4283 VLL 4285
Score = 205 bits (522), Expect = 3e-52
Identities = 175/613 (28%), Positives = 282/613 (46%), Gaps = 77/613 (12%)
Query: 1040 IAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFSPEEIIF 1099
I S + D A ISGL YWF L D+ Y + + L + F F
Sbjct: 4473 IGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTF 4532
Query: 1100 IIQNLLIQILCSI-GYV--------------SSLVFLTYV-ISFIF-------------- 1129
+L S+ GY S + F++YV ++FIF
Sbjct: 4533 RKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFISYVSLNFIFGLCTMLITIMPRLL 4592
Query: 1130 RNGRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPD 1189
K + + + ++ +F+I G + L + + + L + I S +SP
Sbjct: 4593 AIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQI---KYDLTHNFGIDSYVSPF 4649
Query: 1190 SMDYLGASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFP 1249
M++LG ++ ++ L L+ +LR PR ++
Sbjct: 4650 EMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRW-------------------PRGHSTLQ 4690
Query: 1250 NPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIAT 1309
+ ++ D++ E R D +++ L K Y +N IA
Sbjct: 4691 GTVK-SSKDTDVEKEEKRVFEGRTNGD-----ILVLYNLSKHYRRFFQNI-------IAV 4737
Query: 1310 RNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG--------SGGGEPL 1361
+++S + KGE GLLG NGAGKSTT KM+ G+ T+G I++ S G
Sbjct: 4738 QDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAG 4797
Query: 1362 GFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTL 1421
+GYCPQ++AL LT +HL Y +++G+ + L+ L L+ PV T
Sbjct: 4798 VLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATY 4857
Query: 1422 SEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYM 1481
S G KRKL L+++G P ++LLDEPS+GMDP ++ +WQ I R A+LT+H M
Sbjct: 4858 SGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVRE-GCAAVLTSHSM 4916
Query: 1482 AEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRL-FP 1540
E EA+C R+AIMV+G +C+GS QH+K++FG Y +++ L A ++ L+L FP
Sbjct: 4917 EECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFP 4976
Query: 1541 QAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKE 1600
+ + +L+ Y +P + L+ F +E K +++ YS++Q+TLEQVF+ + E
Sbjct: 4977 GIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASE 5035
Query: 1601 QELGDLEEDFDPS 1613
Q+ L+ DPS
Sbjct: 5036 QQ-QTLQSTLDPS 5047
Score = 156 bits (394), Expect = 2e-37
Identities = 156/622 (25%), Positives = 275/622 (44%), Gaps = 67/622 (10%)
Query: 1022 YRSNTFFWIPMAASFTPYIAMSS-----IGDYKKKAHSQLRISGLYPSAYWFGQALVDVS 1076
+ +N F+ P+ T ++++S + + + + +R+ G++P ++ L +++
Sbjct: 3564 FLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMA 3623
Query: 1077 LYFLILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNS 1136
+L + I IF N I L + + S+V L+Y++S F +
Sbjct: 3624 ----VLTISSATLAIVLKTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAA 3679
Query: 1137 GIWSFFFLIVVIFSIVATDL-NEYGFLGLFFGTMLIPPFTLIGSLFI-FSEISP------ 1188
S ++I + IV L N+ F+ F +L G FI F E
Sbjct: 3680 LCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWN 3739
Query: 1189 ---DSMDYLGASESEIVYLALLIPYLHFLIFLFILRCLE--MNCRKKLMR-------KDP 1236
+++ G + + ++ L L+FL ++ + RK K
Sbjct: 3740 NMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSV 3799
Query: 1237 VFRISPR----SNAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEY 1292
F + R S+++F E + + +Q + P + + KEY
Sbjct: 3800 GFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGELEGS--------APGVTLVSVTKEY 3851
Query: 1293 AGKKKNCFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVIL 1352
G K +++S + ++ LLG NGAGK+T I M+TG PT+G +I+
Sbjct: 3852 EGHKA----------VVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIII 3901
Query: 1353 KGSGGGEPLGF----LGYCPQENALWPNLTVRQHLEVYAAVKGLR--KGDAMIAITRLVD 1406
G L LG CPQ++ L NLTVR+HL ++A++K + K + + + +
Sbjct: 3902 NGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQ 3961
Query: 1407 ALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRAT 1466
+ L + LS G+KRKL ++ +G V+LDEP++G+DP + +W ++
Sbjct: 3962 DVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDIL-LK 4020
Query: 1467 FRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLE------- 1519
+R R + TTH++ EAEA+ DRVA++ GRLRC G LK +G+ L
Sbjct: 4021 YREG-RTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSV 4079
Query: 1520 MKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLPVE-DVRPLSQAFFKLEIVKQSF 1578
++ +L M + + I PQA ++ S + Y +P + D L F L+
Sbjct: 4080 LEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQL 4139
Query: 1579 DLEEYSLSQSTLEQVFLELSKE 1600
L Y +S +TLE+VFL L ++
Sbjct: 4140 HLTGYGISDTTLEEVFLMLLQD 4161
Score = 156 bits (394), Expect = 2e-37
Identities = 151/632 (23%), Positives = 273/632 (43%), Gaps = 74/632 (11%)
Query: 211 KILPFVAQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQY-ITSLMTMMGLRESAFWLS 269
KIL + Q GVA + F I+S S + +V ++R L + GL +W +
Sbjct: 4448 KILESIRQCGVALCIVLGFSILSAS-----IGSSVVRDRVIGAKRLQHISGLGYRMYWFT 4502
Query: 270 WGLMYAGFILIMATLMALIVKSAQIVVLT---GFVMVFTLFLLYGLSLITLAFLMSVLIK 326
L F L+ L ++ + Q+ T L L+G + + +LMS +
Sbjct: 4503 NFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFS 4562
Query: 327 KP-----------FLTGLVVFLLIVFWGILGFPALYTRLPAF---LEWTLCLLSPFAFTV 372
F+ GL L+ + +L + L L+W + F
Sbjct: 4563 SSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQ 4622
Query: 373 GMAQLIH--LDYDVNSNAHLDSSQNPYLI--IATLFMLVFD--TLLYLVLTLYFDKILPA 426
G+ +L + + YD+ N +DS +P+ + + +F+ + T+L L+ L +L
Sbjct: 4623 GLVELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRW 4682
Query: 427 EYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEAIRIKNL 486
GH V +TD + FE + + + + NL
Sbjct: 4683 PRGHSTLQ---------------GTVKSSKDTDVEKEEKRVFEGRT----NGDILVLYNL 4723
Query: 487 KKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNH 546
K Y + + A++ + I +G+ LLG +GAGK+T +L+G TSG +
Sbjct: 4724 SKHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIR-- 4781
Query: 547 TLSRMADIENISK------FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQR 600
+ M D ++S G+CPQ + LT E+L + ++GI + +
Sbjct: 4782 --TPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGD 4839
Query: 601 VVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIW-NL 659
+++ L +E D SGG RKL+ +A++G P +LLLDEP++G+DP S+ +W +
Sbjct: 4840 LIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTI 4899
Query: 660 LKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHL-- 717
+KE + + ++ ++E + L R + NG KC GS +K ++G GY + + L
Sbjct: 4900 MKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCK 4959
Query: 718 --NERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSN-QGI 774
N+ C +++ +K + + Q L Y +P +R +L++ ++ I
Sbjct: 4960 EANQHC---TVSDHLKLYFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNI 5015
Query: 775 EDYGVSITTLNEVFLKLEG------KSTIDES 800
+ Y ++ TTL +VF+ +ST+D S
Sbjct: 5016 KHYSINQTTLEQVFINFASEQQQTLQSTLDPS 5047
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 259 bits (662), Expect = 1e-68
Identities = 192/673 (28%), Positives = 328/673 (48%), Gaps = 84/673 (12%)
Query: 201 QLMSVTGVHMKILPFVAQGGVATDFFIF----FCIISFSTFIYYVSVNVT----QERQYI 252
Q + G++++ +P+ V F I F I +IY VS+ V ++ +
Sbjct: 625 QAEAPVGIYLQQMPYPCF--VDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRL 682
Query: 253 TSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGL 312
+ G+ + W +W L + + L+ + + +I+ + ++F L +
Sbjct: 683 KETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFST 742
Query: 313 SLITLAFLMSVLIKKPFLTGL---VVFLLIVFWGILGFPALYTRLPAFLEWTLCLLSPFA 369
+ I L FL+S K L V++ + IL F A R+ A L+ + LLSP A
Sbjct: 743 ATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCF-AWQDRMTAELKKAVSLLSPVA 801
Query: 370 FTVGMAQLIH-------LDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDK 422
F G L+ L + N+ + + +L+ ++ M++ D +Y +L Y D+
Sbjct: 802 FGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLL--SMQMMLLDAAVYGLLAWYLDQ 859
Query: 423 ILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPE-----FCG 477
+ P +YG F L+ +W + ++P + +P PE F
Sbjct: 860 VFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEETEDPEHPEGIHDSFFE 919
Query: 478 KE------AIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILS 531
+E + +KNL K + C R A+ + YE QITA LGH+GAGKTT L+IL+
Sbjct: 920 REHPGWVPGVCVKNLVKIFE-PCGR-PAVDRLNITFYENQITAFLGHNGAGKTTTLSILT 977
Query: 532 GLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILP 591
GL PTSG+V V + D + + G CPQ N+ F LTV E++ +A++KG
Sbjct: 978 GLLPPTSGTVLVGGRDIETSLDA--VRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQ 1035
Query: 592 HEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPL 651
E + E++ ++++ + + ++ AQ+LSGG RKL+ IA +GD +V++LDEPT+G+DP
Sbjct: 1036 EEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPY 1095
Query: 652 SRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGY 711
SR IW+LL + +S R I+ ST +DEAD+L DR I+ G+L C+G+ LFLK +G G
Sbjct: 1096 SRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGL 1155
Query: 712 HLSL-------------------------------HLNERC-------DPESITSLVKQH 733
+L+L H+++ D + +V H
Sbjct: 1156 YLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHH 1215
Query: 734 ISDAKLTAQSEEKLVYILPLE--RTNKFPELYRDLDR-CSNQGIEDYGVSITTLNEVFLK 790
+ +AKL ++L+++LP + + + L+R+L+ ++ G+ +G+S T L E+FLK
Sbjct: 1216 VPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLK 1275
Query: 791 LEGKSTIDESDIG 803
+ ++SD G
Sbjct: 1276 V-----TEDSDSG 1283
Score = 209 bits (533), Expect = 1e-53
Identities = 178/611 (29%), Positives = 277/611 (45%), Gaps = 96/611 (15%)
Query: 1034 ASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL-------ILLLMQ 1086
ASF Y+ + K H Q ISG+ P+ YW L D+ Y + I + Q
Sbjct: 1695 ASFVLYLIQERVN---KSKHLQF-ISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQ 1750
Query: 1087 IMDYIFSPEEIIFIIQNLLIQ--ILCSIGYVSSLVF----LTYV---------------I 1125
Y SPE + ++ LL+ + + Y +S +F YV I
Sbjct: 1751 KKAYT-SPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAI 1809
Query: 1126 SFIFRNGRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSE 1185
+FI N + F ++ + + G + L + + G
Sbjct: 1810 TFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEH---S 1866
Query: 1186 ISPDSMDYLGAS------ESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFR 1239
+P D +G + E + +L L+ HF + +I
Sbjct: 1867 ANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAE------------------ 1908
Query: 1240 ISPRSNAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNC 1299
P E E++D+ ER R + ++T ++ L K Y G
Sbjct: 1909 ---------PTKEPIVDEDDDVAEERQRIITGG-----NKTDILRLHELTKIYPGTSSP- 1953
Query: 1300 FSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG----S 1355
A + V+ GE GLLG NGAGK+TT KM+TGDT T+G + G +
Sbjct: 1954 --------AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILT 2005
Query: 1356 GGGEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLK 1415
E +GYCPQ +A+ LT R+HL +YA ++G+ + + +L L
Sbjct: 2006 NISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYAD 2065
Query: 1416 APVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGAL 1475
T S G KRKL ++++G P +VLLDEP+TGMDP+ ++ +W VI + R R +
Sbjct: 2066 CLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREG-RAVV 2124
Query: 1476 LTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKN-----LAQMEP 1530
LT+H M E EA+C R+AIMV G RC+G+IQHLKSKFG Y++ MK+K+ L + P
Sbjct: 2125 LTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNP 2184
Query: 1531 LHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTL 1590
+ FP + Q+ER +++ +++ L++ F L K S +EEYS++Q+TL
Sbjct: 2185 VEQFFQGNFPGSVQRERHYNMLQFQVSSSS---LARIFQLLLSHKDSLLIEEYSVTQTTL 2241
Query: 1591 EQVFLELSKEQ 1601
+QVF+ +K+Q
Sbjct: 2242 DQVFVNFAKQQ 2252
Score = 159 bits (402), Expect = 2e-38
Identities = 158/627 (25%), Positives = 279/627 (44%), Gaps = 69/627 (11%)
Query: 200 EQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMM 259
EQL +T + + VA + F + F SF ++ VN ++ Q+I+
Sbjct: 1666 EQLSEITVLTTSVDAVVA---ICVIFSMSFVPASFVLYLIQERVNKSKHLQFIS------ 1716
Query: 260 GLRESAFWLS---WGLMYAGFILIMATLMALIVKSAQIVVLTG---FVMVFTLFLLYGLS 313
G+ + +W++ W +M + A L+ I Q T + L LLYG +
Sbjct: 1717 GVSPTTYWVTNFLWDIMNYS---VSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWA 1773
Query: 314 LITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYT-----------RLPAFLEWTL 362
+I + + S L P + + +F GI + R A L L
Sbjct: 1774 VIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLL 1833
Query: 363 CLLSPFAFTVGMAQLI--HLDYDVNSNAHLDSSQNPY---LIIATLFMLVFDTLLYLVLT 417
+ F G+ L DV + + S NP+ LI LF +V + ++Y +LT
Sbjct: 1834 IVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLT 1893
Query: 418 LYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCG 477
L + FFL W +V E++ ++ + +
Sbjct: 1894 LLVQRH------------FFLSQ--WIAEPTKEPIVDEDDDVAEER-----QRIITGGNK 1934
Query: 478 KEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPT 537
+ +R+ L K Y G A+ + + G+ LLG +GAGKTT +L+G + T
Sbjct: 1935 TDILRLHELTKIYPGTSS--PAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVT 1992
Query: 538 SGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKE 597
SG TV ++ + +I + + G+CPQ + LT +E+L L+A+++G+ E+EK
Sbjct: 1993 SGDATVAGKSI--LTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKV 2050
Query: 598 VQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIW 657
++ L + D LA SGG RKL+ IA++G P ++LLDEPT G+DP +R +W
Sbjct: 2051 ANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLW 2110
Query: 658 N----LLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHL 713
N +++EG R ++ ++ ++E + L R + G +C G+ LK K+G GY +
Sbjct: 2111 NVIVSIIREG---RAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIV 2167
Query: 714 SLHLNERCDPESITSL--VKQHISDAKLTAQSEEKLVYILPLE-RTNKFPELYR-DLDRC 769
++ + D + + L V+Q + E+ +L + ++ +++ L
Sbjct: 2168 TMKIKSPKD-DLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHK 2226
Query: 770 SNQGIEDYGVSITTLNEVFLKLEGKST 796
+ IE+Y V+ TTL++VF+ + T
Sbjct: 2227 DSLLIEEYSVTQTTLDQVFVNFAKQQT 2253
Score = 150 bits (380), Expect = 7e-36
Identities = 97/340 (28%), Positives = 173/340 (50%), Gaps = 48/340 (14%)
Query: 1311 NVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGF----LGY 1366
N++F + ++ LGHNGAGK+TT+ ++TG PT+G V++ G L LG
Sbjct: 950 NITFY--ENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGM 1007
Query: 1367 CPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIK 1426
CPQ N L+ +LTV +H+ YA +KG + +A + + +++ L + + LS G++
Sbjct: 1008 CPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQ 1067
Query: 1427 RKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEA 1486
RKL ++ +G+ VV+LDEP++G+DP ++ +W ++ + R +++TH+M EA+
Sbjct: 1068 RKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLK--YRSGRTIIMSTHHMDEADL 1125
Query: 1487 VCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM--KLKNLAQME--------------- 1529
+ DR+AI+ GRL C G+ LK+ FG L + K+KN+
Sbjct: 1126 LGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFS 1185
Query: 1530 ---PLHAE------------------ILRLFPQAAQQERFSSLMVYKLPVEDV--RPLSQ 1566
P H + +L P+A E +++ LP ++ R +
Sbjct: 1186 TTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYAS 1245
Query: 1567 AFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDL 1606
F +LE L + +S + LE++FL+++++ + G L
Sbjct: 1246 LFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPL 1285
>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 124 bits (310), Expect = 1e-27
Identities = 58/164 (35%), Positives = 103/164 (62%), Gaps = 1/164 (0%)
Query: 1377 LTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSIL 1436
+T ++ + +YA + G+ + + + + +++L+L+ + T SEG KR+L ++++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1437 GNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVS 1496
G SV+ LDEPSTGMDP ++ +W ++ T R + + ++T+H M E +A+C +AIMV
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119
Query: 1497 GRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFP 1540
G+ C+GS QHLKSKFG Y+L++K+K ++E + FP
Sbjct: 120 GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 85.5 bits (210), Expect = 4e-16
Identities = 45/143 (31%), Positives = 80/143 (55%), Gaps = 1/143 (0%)
Query: 574 LTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAIL 633
+T +E + ++A+I G+ ++ V + + LE+E+ L S G R+L+ IA++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 634 GDPQVLLLDEPTAGLDPLSRHRIWNLL-KEGKSDRVILFSTQFIDEADILADRKVFISNG 692
G V+ LDEP+ G+DP++R +WN++ K +S + I+ ++ ++E D L + G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 693 KLKCAGSSLFLKKKWGIGYHLSL 715
K C GS LK K+G Y L +
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 124 bits (310), Expect = 1e-27
Identities = 58/164 (35%), Positives = 103/164 (62%), Gaps = 1/164 (0%)
Query: 1377 LTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSIL 1436
+T ++ + +YA + G+ + + + + +++L+L+ + T SEG KR+L ++++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1437 GNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVS 1496
G SV+ LDEPSTGMDP ++ +W ++ T R + + ++T+H M E +A+C +AIMV
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119
Query: 1497 GRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFP 1540
G+ C+GS QHLKSKFG Y+L++K+K ++E + FP
Sbjct: 120 GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 85.5 bits (210), Expect = 4e-16
Identities = 45/143 (31%), Positives = 80/143 (55%), Gaps = 1/143 (0%)
Query: 574 LTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAIL 633
+T +E + ++A+I G+ ++ V + + LE+E+ L S G R+L+ IA++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 634 GDPQVLLLDEPTAGLDPLSRHRIWNLL-KEGKSDRVILFSTQFIDEADILADRKVFISNG 692
G V+ LDEP+ G+DP++R +WN++ K +S + I+ ++ ++E D L + G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 693 KLKCAGSSLFLKKKWGIGYHLSL 715
K C GS LK K+G Y L +
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 124 bits (310), Expect = 1e-27
Identities = 58/164 (35%), Positives = 103/164 (62%), Gaps = 1/164 (0%)
Query: 1377 LTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSIL 1436
+T ++ + +YA + G+ + + + + +++L+L+ + T SEG KR+L ++++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1437 GNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVS 1496
G SV+ LDEPSTGMDP ++ +W ++ T R + + ++T+H M E +A+C +AIMV
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119
Query: 1497 GRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFP 1540
G+ C+GS QHLKSKFG Y+L++K+K ++E + FP
Sbjct: 120 GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 85.5 bits (210), Expect = 4e-16
Identities = 45/143 (31%), Positives = 80/143 (55%), Gaps = 1/143 (0%)
Query: 574 LTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAIL 633
+T +E + ++A+I G+ ++ V + + LE+E+ L S G R+L+ IA++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 634 GDPQVLLLDEPTAGLDPLSRHRIWNLL-KEGKSDRVILFSTQFIDEADILADRKVFISNG 692
G V+ LDEP+ G+DP++R +WN++ K +S + I+ ++ ++E D L + G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 693 KLKCAGSSLFLKKKWGIGYHLSL 715
K C GS LK K+G Y L +
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
>gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
sapiens]
Length = 655
Score = 92.0 bits (227), Expect = 4e-18
Identities = 57/170 (33%), Positives = 95/170 (55%), Gaps = 12/170 (7%)
Query: 512 ITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQF 571
+ A+LG +G GK++LL++L+ P+ S V + R A N +G+ Q +V
Sbjct: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPA---NFKCNSGYVVQDDVVM 131
Query: 572 GFLTVKENLRLFAKIK---GILPHEVEKEVQRVVQELEMENIQDI-----LAQNLSGGQN 623
G LTV+ENL+ A ++ + HE + + RV+QEL ++ + D + +SGG+
Sbjct: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
Query: 624 RKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKE-GKSDRVILFS 672
++ + G+ ++ DP +L LDEPT GLD + + + LLK K R I+FS
Sbjct: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFS 241
Score = 58.5 bits (140), Expect = 5e-08
Identities = 57/238 (23%), Positives = 110/238 (46%), Gaps = 21/238 (8%)
Query: 1292 YAGKKKNCFSKRKKKIATR---NVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPT-- 1346
Y K K+ F +K + N++ +K G + +LG G GKS+ + ++ P+
Sbjct: 44 YRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGL 102
Query: 1347 AGQVILKGSGGGEPLGFL---GYCPQENALWPNLTVRQHLEVYAAVK---GLRKGDAMIA 1400
+G V++ G+ P F GY Q++ + LTVR++L+ AA++ + +
Sbjct: 103 SGDVLINGAP--RPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNER 160
Query: 1401 ITRLVDALKLQDQLKAPVKT-----LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEG 1455
I R++ L L + V T +S G +++ + ++ +PS++ LDEP+TG+D
Sbjct: 161 INRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSST 220
Query: 1456 QQQMWQVIRATFRNTERGALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKF 1512
+ +++ + R + + H + D + ++ SGRL G Q F
Sbjct: 221 ANAVLLLLKRMSKQ-GRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYF 277
>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo
sapiens]
Length = 651
Score = 86.7 bits (213), Expect = 2e-16
Identities = 70/214 (32%), Positives = 109/214 (50%), Gaps = 16/214 (7%)
Query: 498 EALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTS---GSVTVYNHTLSRMADI 554
+ LK V + GQI +LG SG+GKTTLL+ +SG G V V L R
Sbjct: 67 QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRR---- 122
Query: 555 ENISKFTGFCPQSNVQFGFLTVKENLRLFA--KIKGILPHEVEKEVQRVVQELEMENIQD 612
E + QS+ LTV+E L A I+ P +K+V+ V+ EL + ++ D
Sbjct: 123 EQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVAD 182
Query: 613 ILAQN-----LSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKE-GKSD 666
L N +S G+ R+++ +L DP+V+L DEPT GLD ++ ++I LL E + +
Sbjct: 183 RLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRN 242
Query: 667 RVILFST-QFIDEADILADRKVFISNGKLKCAGS 699
R+++ + Q E L D+ +S G+L G+
Sbjct: 243 RIVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
Score = 62.0 bits (149), Expect = 5e-09
Identities = 56/213 (26%), Positives = 102/213 (47%), Gaps = 24/213 (11%)
Query: 1310 RNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTA---GQVILKGSG--GGEPLGFL 1364
++VS V+ G+++ +LG +G+GK+T + ++G G+V + G +
Sbjct: 70 KDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCF 129
Query: 1365 GYCPQENALWPNLTVRQHLEVYAAVKGLRKGD------------AMIAITRLVDALKLQD 1412
Y Q + L +LTVR+ L Y A+ +R+G+ A ++++ + D L
Sbjct: 130 SYVLQSDTLLSSLTVRETLH-YTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNY 188
Query: 1413 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTER 1472
L +S G +R++ +L +P V+L DEP+TG+D Q+ V+ R
Sbjct: 189 SLGG----ISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQI-VVLLVELARRNR 243
Query: 1473 GALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGS 1504
+LT H +E + D++AI+ G L G+
Sbjct: 244 IVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
>gi|11967971 ATP-binding cassette sub-family G member 8 [Homo
sapiens]
Length = 673
Score = 82.8 bits (203), Expect = 2e-15
Identities = 75/285 (26%), Positives = 133/285 (46%), Gaps = 32/285 (11%)
Query: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVP---TSGSVTVYNHTLSRMADIEN 556
++ + F + GQ+ A++G SG G+ +LL++++G SG + + S
Sbjct: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL---- 143
Query: 557 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPH-----EVEKEVQRVVQELEMENIQ 611
+ K Q N LTV+E L A+++ LP + +K V+ V+ EL +
Sbjct: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMR--LPRTFSQAQRDKRVEDVIAELRLRQCA 201
Query: 612 DILAQN-----LSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKE-GKS 665
D N LSGG+ R+++ G+ +L +P +L+LDEPT+GLD + H + L K
Sbjct: 202 DTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKG 261
Query: 666 DRVILFSTQFIDEADI--LADRKVFISNGKLKCAGSSLFLKKKW-GIGYHLSLHLNERCD 722
+R++L S +DI L D + +++G G++ + + + IGY + N
Sbjct: 262 NRLVLISLH-QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADF 320
Query: 723 PESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLD 767
+TS+ ++ T + + L + F E RDLD
Sbjct: 321 YVDLTSIDRRSREQELATREKAQSLAAL--------FLEKVRDLD 357
Score = 74.3 bits (181), Expect = 9e-13
Identities = 72/302 (23%), Positives = 143/302 (47%), Gaps = 25/302 (8%)
Query: 1306 KIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITG---DTKPTAGQVILKGSGGGEPL- 1361
++ +N+SF V+ G+++ ++G +G G+++ + +ITG K +GQ+ + G L
Sbjct: 85 ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLV 144
Query: 1362 -GFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDA---LKLQDQLKAP 1417
+ + Q N L PNLTVR+ L A ++ R R+ D L+L+
Sbjct: 145 RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTR 204
Query: 1418 V-----KTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTER 1472
V + LS G +R++ + +L NP +++LDEP++G+D + + + + R
Sbjct: 205 VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTL-SRLAKGNR 263
Query: 1473 GALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPL 1531
L++ H ++ + D V +M SG +G+ QH+ F + +
Sbjct: 264 LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF---TAIGYPCPRYSNPADF 320
Query: 1532 HAEILRLFPQAAQQE---RFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQS 1588
+ ++ + ++ +QE R + + L +E VR L +K E + DL+E + +S
Sbjct: 321 YVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAE----TKDLDEDTCVES 376
Query: 1589 TL 1590
++
Sbjct: 377 SV 378
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 82.4 bits (202), Expect = 3e-15
Identities = 77/292 (26%), Positives = 137/292 (46%), Gaps = 26/292 (8%)
Query: 415 VLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHV--VLENETDSDPTPNDCFEPVS 472
VLT++F ++ A + SP F G A + +++N+ D +P +
Sbjct: 331 VLTVFFSVLIGAFSVGQASPSI---EAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDN 387
Query: 473 PEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSG 532
K + +N+ Y + E V+ LKG+ + GQ AL+G+SG GK+T + ++
Sbjct: 388 I----KGNLEFRNVHFSYPSRKE-VKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQR 442
Query: 533 LSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPH 592
L PT G V+V + R ++ + + G Q V F T+ EN+R + +
Sbjct: 443 LYDPTEGMVSVDGQDI-RTINVRFLREIIGVVSQEPVLFA-TTIAENIRYGR--ENVTMD 498
Query: 593 EVEKEVQRV-----VQEL--EMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPT 645
E+EK V+ + +L + + + LSGGQ +++ A++ +P++LLLDE T
Sbjct: 499 EIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 558
Query: 646 AGLDPLSRHRIWNLL---KEGKSDRVILFSTQFIDEADILA--DRKVFISNG 692
+ LD S + L ++G++ VI + AD++A D V + G
Sbjct: 559 SALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKG 610
Score = 72.4 bits (176), Expect = 3e-12
Identities = 57/227 (25%), Positives = 107/227 (47%), Gaps = 16/227 (7%)
Query: 497 VEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIEN 556
+ L+G+ ++ +GQ AL+G SG GK+T++ +L P +G V + + R+ +++
Sbjct: 1050 IPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRL-NVQW 1108
Query: 557 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEV-----EKEVQRVVQELEMENIQ 611
+ G Q + F ++ EN+ + + E+ E + ++ L +
Sbjct: 1109 LRAHLGIVSQEPILFD-CSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYST 1167
Query: 612 DI--LAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLL---KEGKSD 666
+ LSGGQ +++ A++ P +LLLDE T+ LD S + L +EG++
Sbjct: 1168 KVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1227
Query: 667 RVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHL 713
VI I AD++ V NG++K G+ L + GI + +
Sbjct: 1228 IVIAHRLSTIQNADLI----VVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
Score = 56.6 bits (135), Expect = 2e-07
Identities = 51/222 (22%), Positives = 99/222 (44%), Gaps = 28/222 (12%)
Query: 1310 RNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSG------------- 1356
+ +S VKKG+ + L+G +G GKST ++++ P AG+V+L G
Sbjct: 1054 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHL 1113
Query: 1357 ---GGEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQ 1413
EP+ F + A N V E+ A K I +++L +
Sbjct: 1114 GIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEAN-------IHAFIESLPNKYS 1166
Query: 1414 LKAPVK--TLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTE 1471
K K LS G K+++ +++ P ++LLDE ++ +D E ++ + + +
Sbjct: 1167 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA--REG 1224
Query: 1472 RGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFG 1513
R ++ H ++ + D + + +GR++ G+ Q L ++ G
Sbjct: 1225 RTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKG 1265
Score = 52.8 bits (125), Expect = 3e-06
Identities = 43/172 (25%), Positives = 83/172 (48%), Gaps = 21/172 (12%)
Query: 1300 FSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSG-GG 1358
+ RK+ + ++ V+ G+ + L+G++G GKSTT++++ PT G V + G
Sbjct: 401 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRT 460
Query: 1359 EPLGFL----GYCPQENALWPNLTVRQHL----------EVYAAVKGLRKGDAMIAITRL 1404
+ FL G QE L+ T+ +++ E+ AVK D ++ +
Sbjct: 461 INVRFLREIIGVVSQEPVLFAT-TIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHK 519
Query: 1405 VDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQ 1456
D L + + LS G K+++ +++ NP ++LLDE ++ +D E +
Sbjct: 520 FDTLVGERGAQ-----LSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 566
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 79.0 bits (193), Expect = 4e-14
Identities = 52/163 (31%), Positives = 90/163 (55%), Gaps = 4/163 (2%)
Query: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISK 559
LKG+ G++ A++G SGAGK+TL+NIL+G T V + L R D+ K
Sbjct: 98 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYR-ETGMKGAVLINGLPR--DLRCFRK 154
Query: 560 FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKE-VQRVVQELEMENIQDILAQNL 618
+ + Q ++ LTV+E + + A +K E +E V+ ++ L + + + +L
Sbjct: 155 VSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSL 214
Query: 619 SGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLK 661
SGGQ ++L + ++ +P V+ DEPT+GLD S ++ +L+K
Sbjct: 215 SGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 257
Score = 62.8 bits (151), Expect = 3e-09
Identities = 51/212 (24%), Positives = 102/212 (48%), Gaps = 6/212 (2%)
Query: 1302 KRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPL 1361
K+ K + +S GE++ ++G +GAGKST + ++ G + +L +
Sbjct: 91 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 150
Query: 1362 GFLG---YCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITR-LVDALKLQDQLKAP 1417
F Y Q++ L P+LTV++ + V A +K K + + + ++ AL L
Sbjct: 151 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 210
Query: 1418 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLT 1477
+LS G +++L L ++ NP V+ DEP++G+D Q+ +++ + R + T
Sbjct: 211 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 269
Query: 1478 THY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1508
H A+ + D++ ++ G+ G + +L
Sbjct: 270 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 301
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 79.0 bits (193), Expect = 4e-14
Identities = 52/163 (31%), Positives = 90/163 (55%), Gaps = 4/163 (2%)
Query: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISK 559
LKG+ G++ A++G SGAGK+TL+NIL+G T V + L R D+ K
Sbjct: 79 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYR-ETGMKGAVLINGLPR--DLRCFRK 135
Query: 560 FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKE-VQRVVQELEMENIQDILAQNL 618
+ + Q ++ LTV+E + + A +K E +E V+ ++ L + + + +L
Sbjct: 136 VSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSL 195
Query: 619 SGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLK 661
SGGQ ++L + ++ +P V+ DEPT+GLD S ++ +L+K
Sbjct: 196 SGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 238
Score = 62.8 bits (151), Expect = 3e-09
Identities = 51/212 (24%), Positives = 102/212 (48%), Gaps = 6/212 (2%)
Query: 1302 KRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPL 1361
K+ K + +S GE++ ++G +GAGKST + ++ G + +L +
Sbjct: 72 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 131
Query: 1362 GFLG---YCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITR-LVDALKLQDQLKAP 1417
F Y Q++ L P+LTV++ + V A +K K + + + ++ AL L
Sbjct: 132 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 191
Query: 1418 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLT 1477
+LS G +++L L ++ NP V+ DEP++G+D Q+ +++ + R + T
Sbjct: 192 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 250
Query: 1478 THY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1508
H A+ + D++ ++ G+ G + +L
Sbjct: 251 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 282
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 79.0 bits (193), Expect = 4e-14
Identities = 52/163 (31%), Positives = 90/163 (55%), Gaps = 4/163 (2%)
Query: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISK 559
LKG+ G++ A++G SGAGK+TL+NIL+G T V + L R D+ K
Sbjct: 103 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYR-ETGMKGAVLINGLPR--DLRCFRK 159
Query: 560 FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKE-VQRVVQELEMENIQDILAQNL 618
+ + Q ++ LTV+E + + A +K E +E V+ ++ L + + + +L
Sbjct: 160 VSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSL 219
Query: 619 SGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLK 661
SGGQ ++L + ++ +P V+ DEPT+GLD S ++ +L+K
Sbjct: 220 SGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 262
Score = 62.8 bits (151), Expect = 3e-09
Identities = 51/212 (24%), Positives = 102/212 (48%), Gaps = 6/212 (2%)
Query: 1302 KRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPL 1361
K+ K + +S GE++ ++G +GAGKST + ++ G + +L +
Sbjct: 96 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 155
Query: 1362 GFLG---YCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITR-LVDALKLQDQLKAP 1417
F Y Q++ L P+LTV++ + V A +K K + + + ++ AL L
Sbjct: 156 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 215
Query: 1418 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLT 1477
+LS G +++L L ++ NP V+ DEP++G+D Q+ +++ + R + T
Sbjct: 216 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 274
Query: 1478 THY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1508
H A+ + D++ ++ G+ G + +L
Sbjct: 275 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 306
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 79.0 bits (193), Expect = 4e-14
Identities = 52/163 (31%), Positives = 90/163 (55%), Gaps = 4/163 (2%)
Query: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISK 559
LKG+ G++ A++G SGAGK+TL+NIL+G T V + L R D+ K
Sbjct: 112 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYR-ETGMKGAVLINGLPR--DLRCFRK 168
Query: 560 FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKE-VQRVVQELEMENIQDILAQNL 618
+ + Q ++ LTV+E + + A +K E +E V+ ++ L + + + +L
Sbjct: 169 VSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSL 228
Query: 619 SGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLK 661
SGGQ ++L + ++ +P V+ DEPT+GLD S ++ +L+K
Sbjct: 229 SGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 271
Score = 62.8 bits (151), Expect = 3e-09
Identities = 51/212 (24%), Positives = 102/212 (48%), Gaps = 6/212 (2%)
Query: 1302 KRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPL 1361
K+ K + +S GE++ ++G +GAGKST + ++ G + +L +
Sbjct: 105 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 164
Query: 1362 GFLG---YCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITR-LVDALKLQDQLKAP 1417
F Y Q++ L P+LTV++ + V A +K K + + + ++ AL L
Sbjct: 165 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 224
Query: 1418 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLT 1477
+LS G +++L L ++ NP V+ DEP++G+D Q+ +++ + R + T
Sbjct: 225 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 283
Query: 1478 THY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1508
H A+ + D++ ++ G+ G + +L
Sbjct: 284 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 315
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 79.0 bits (193), Expect = 4e-14
Identities = 52/163 (31%), Positives = 90/163 (55%), Gaps = 4/163 (2%)
Query: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISK 559
LKG+ G++ A++G SGAGK+TL+NIL+G T V + L R D+ K
Sbjct: 101 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYR-ETGMKGAVLINGLPR--DLRCFRK 157
Query: 560 FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKE-VQRVVQELEMENIQDILAQNL 618
+ + Q ++ LTV+E + + A +K E +E V+ ++ L + + + +L
Sbjct: 158 VSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSL 217
Query: 619 SGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLK 661
SGGQ ++L + ++ +P V+ DEPT+GLD S ++ +L+K
Sbjct: 218 SGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 260
Score = 62.8 bits (151), Expect = 3e-09
Identities = 51/212 (24%), Positives = 102/212 (48%), Gaps = 6/212 (2%)
Query: 1302 KRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPL 1361
K+ K + +S GE++ ++G +GAGKST + ++ G + +L +
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 153
Query: 1362 GFLG---YCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITR-LVDALKLQDQLKAP 1417
F Y Q++ L P+LTV++ + V A +K K + + + ++ AL L
Sbjct: 154 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 213
Query: 1418 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLT 1477
+LS G +++L L ++ NP V+ DEP++G+D Q+ +++ + R + T
Sbjct: 214 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 272
Query: 1478 THY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1508
H A+ + D++ ++ G+ G + +L
Sbjct: 273 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 304
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 79.0 bits (193), Expect = 4e-14
Identities = 52/163 (31%), Positives = 90/163 (55%), Gaps = 4/163 (2%)
Query: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISK 559
LKG+ G++ A++G SGAGK+TL+NIL+G T V + L R D+ K
Sbjct: 101 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYR-ETGMKGAVLINGLPR--DLRCFRK 157
Query: 560 FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKE-VQRVVQELEMENIQDILAQNL 618
+ + Q ++ LTV+E + + A +K E +E V+ ++ L + + + +L
Sbjct: 158 VSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSL 217
Query: 619 SGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLK 661
SGGQ ++L + ++ +P V+ DEPT+GLD S ++ +L+K
Sbjct: 218 SGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 260
Score = 62.8 bits (151), Expect = 3e-09
Identities = 51/212 (24%), Positives = 102/212 (48%), Gaps = 6/212 (2%)
Query: 1302 KRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPL 1361
K+ K + +S GE++ ++G +GAGKST + ++ G + +L +
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 153
Query: 1362 GFLG---YCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITR-LVDALKLQDQLKAP 1417
F Y Q++ L P+LTV++ + V A +K K + + + ++ AL L
Sbjct: 154 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 213
Query: 1418 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLT 1477
+LS G +++L L ++ NP V+ DEP++G+D Q+ +++ + R + T
Sbjct: 214 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 272
Query: 1478 THY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1508
H A+ + D++ ++ G+ G + +L
Sbjct: 273 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 304
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 75.1 bits (183), Expect = 5e-13
Identities = 65/223 (29%), Positives = 102/223 (45%), Gaps = 19/223 (8%)
Query: 498 EALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENI 557
E LK + G+I AL+G SG GKTT+ ++L PT+G V + L +
Sbjct: 471 EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLR 530
Query: 558 SKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEM--------EN 609
+ GF Q V FG T+ EN+R F K++ ++EV +E E
Sbjct: 531 GQVVGFISQEPVLFG-TTIMENIR-FGKLEA-----SDEEVYTAAREANAHEFITSFPEG 583
Query: 610 IQDILAQ---NLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSD 666
++ + LSGGQ ++L A++ P VL+LDE T+ LD S + L +
Sbjct: 584 YNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAG 643
Query: 667 RVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGI 709
R +L + A V +++G++ AG+ L KK G+
Sbjct: 644 RTVLVIAHRLSTVR-GAHCIVVMADGRVWEAGTHEELLKKGGL 685
Score = 57.4 bits (137), Expect = 1e-07
Identities = 54/221 (24%), Positives = 100/221 (45%), Gaps = 27/221 (12%)
Query: 1310 RNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSG---------GGEP 1360
++ + + G+++ L+G +G GK+T ++ PTAG V+L G G+
Sbjct: 474 KDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQV 533
Query: 1361 LGFLGYCP-------QENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQ 1413
+GF+ P EN + L EVY A R+ +A IT +
Sbjct: 534 VGFISQEPVLFGTTIMENIRFGKLEASDE-EVYTAA---REANAHEFITSFPEGYNTVVG 589
Query: 1414 LKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERG 1473
+ TLS G K++L +++ P+V++LDE ++ +D E ++ + + + + R
Sbjct: 590 ERG--TTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRA--SAGRT 645
Query: 1474 ALLTTHYMAEAE-AVCDRVAIMVSGRLRCIGSIQHLKSKFG 1513
L+ H ++ A C + +M GR+ G+ + L K G
Sbjct: 646 VLVIAHRLSTVRGAHC--IVVMADGRVWEAGTHEELLKKGG 684
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 74.7 bits (182), Expect = 7e-13
Identities = 61/227 (26%), Positives = 110/227 (48%), Gaps = 18/227 (7%)
Query: 497 VEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIEN 556
V+ LKG+ + GQ AL+G SG GK+T + ++ L P G++ + + R ++
Sbjct: 409 VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDI-RNFNVNY 467
Query: 557 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRV-----VQEL--EMEN 609
+ + G Q V F T+ EN+ + + + E++K V+ + +L + +
Sbjct: 468 LREIIGVVSQEPVLFS-TTIAENI-CYGR-GNVTMDEIKKAVKEANAYEFIMKLPQKFDT 524
Query: 610 IQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLL---KEGKSD 666
+ LSGGQ +++ A++ +P++LLLDE T+ LD S + L +EG++
Sbjct: 525 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTT 584
Query: 667 RVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHL 713
VI + AD++A +G + GS L KK G+ + L
Sbjct: 585 IVIAHRLSTVRNADVIAG----FEDGVIVEQGSHSELMKKEGVYFKL 627
Score = 67.0 bits (162), Expect = 1e-10
Identities = 59/233 (25%), Positives = 108/233 (46%), Gaps = 21/233 (9%)
Query: 497 VEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTV------YNHTLSR 550
V L+G+ ++ +GQ AL+G SG GK+T++ +L P +G+V V + ++
Sbjct: 1049 VPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAK 1108
Query: 551 MADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEK-----EVQRVVQEL 605
+++ + G Q + F ++ EN+ + + E+ + ++ L
Sbjct: 1109 KLNVQWLRAQLGIVSQEPILFD-CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL 1167
Query: 606 --EMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLL--- 660
+ E LSGGQ +++ A++ PQ+LLLDE T+ LD S + L
Sbjct: 1168 PHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKA 1227
Query: 661 KEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHL 713
+EG++ VI I AD++ V NG++K G+ L + GI + +
Sbjct: 1228 REGRTCIVIAHRLSTIQNADLI----VVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
Score = 51.2 bits (121), Expect = 8e-06
Identities = 49/229 (21%), Positives = 98/229 (42%), Gaps = 35/229 (15%)
Query: 1310 RNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILK---------------- 1353
+ +S VKKG+ + L+G +G GKST ++++ P AG V +
Sbjct: 1053 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNV 1112
Query: 1354 -------GSGGGEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVD 1406
G EP+ F + A N V E+ +A K I ++
Sbjct: 1113 QWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAAN-------IHPFIE 1165
Query: 1407 AL--KLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIR 1464
L K + ++ LS G K+++ +++ P ++LLDE ++ +D E ++ + + +
Sbjct: 1166 TLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALD 1225
Query: 1465 ATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFG 1513
R ++ H ++ + D + + +GR++ G+ Q L ++ G
Sbjct: 1226 KA--REGRTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKG 1271
Score = 48.5 bits (114), Expect = 5e-05
Identities = 37/165 (22%), Positives = 79/165 (47%), Gaps = 21/165 (12%)
Query: 1310 RNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGS-----GGGEPLGFL 1364
+ ++ V+ G+ + L+G +G GKSTT+++I P G + + G +
Sbjct: 413 KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
Query: 1365 GYCPQENALWPNLTVRQHL----------EVYAAVKGLRKGDAMIAITRLVDALKLQDQL 1414
G QE L+ + T+ +++ E+ AVK + ++ + + D L +
Sbjct: 473 GVVSQEPVLF-STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
Query: 1415 KAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQM 1459
+ LS G K+++ +++ NP ++LLDE ++ +D E + ++
Sbjct: 532 Q-----LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,919,089
Number of Sequences: 37866
Number of extensions: 2563554
Number of successful extensions: 9255
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 8521
Number of HSP's gapped (non-prelim): 403
length of query: 1624
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1508
effective length of database: 13,855,062
effective search space: 20893433496
effective search space used: 20893433496
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.