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Search of human proteins with 25168261
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25168261 serum/glucocorticoid regulated kinase 2 isoform
alpha [Homo sapiens]
(367 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 757 0.0
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 757 0.0
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 545 e-155
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 545 e-155
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 545 e-155
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 545 e-155
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 513 e-145
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 513 e-145
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 434 e-122
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 341 5e-94
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 341 5e-94
gi|4502023 AKT2 kinase [Homo sapiens] 338 6e-93
gi|62241015 AKT1 kinase [Homo sapiens] 333 1e-91
gi|62241013 AKT1 kinase [Homo sapiens] 333 1e-91
gi|62241011 AKT1 kinase [Homo sapiens] 333 1e-91
gi|133908623 protein kinase C, iota [Homo sapiens] 302 3e-82
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 302 3e-82
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 299 3e-81
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 295 3e-80
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 295 3e-80
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 295 3e-80
gi|4885563 protein kinase C, epsilon [Homo sapiens] 292 3e-79
gi|28557781 protein kinase C, eta [Homo sapiens] 289 3e-78
gi|13384594 protein kinase C, gamma [Homo sapiens] 282 3e-76
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 281 5e-76
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 281 7e-76
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 281 7e-76
gi|4506067 protein kinase C, alpha [Homo sapiens] 279 3e-75
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 278 6e-75
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 278 7e-75
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 757 bits (1954), Expect = 0.0
Identities = 367/367 (100%), Positives = 367/367 (100%)
Query: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF
Sbjct: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
Query: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 120
YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE
Sbjct: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 120
Query: 121 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 180
LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL
Sbjct: 121 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 180
Query: 181 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 240
CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS
Sbjct: 181 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 240
Query: 241 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 300
QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL
Sbjct: 241 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 300
Query: 301 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE 360
YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE
Sbjct: 301 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE 360
Query: 361 DDDILDC 367
DDDILDC
Sbjct: 361 DDDILDC 367
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 757 bits (1954), Expect = 0.0
Identities = 367/367 (100%), Positives = 367/367 (100%)
Query: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF
Sbjct: 61 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 120
Query: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 120
YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE
Sbjct: 121 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 180
Query: 121 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 180
LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL
Sbjct: 181 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 240
Query: 181 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 240
CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS
Sbjct: 241 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 300
Query: 241 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 300
QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL
Sbjct: 301 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 360
Query: 301 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE 360
YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE
Sbjct: 361 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE 420
Query: 361 DDDILDC 367
DDDILDC
Sbjct: 421 DDDILDC 427
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 545 bits (1404), Expect = e-155
Identities = 261/368 (70%), Positives = 313/368 (85%), Gaps = 8/368 (2%)
Query: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
MN++P+ PSP INLGPS+NP+A+P+DF FLKVIGKG++GKVLLA+ K++ F
Sbjct: 69 MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 123
Query: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 120
YAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLVGL +SFQT +KLYFVLDY+NGGE
Sbjct: 124 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 183
Query: 121 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 180
LF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+YRDLKPENILLD QGH+VLTDFGL
Sbjct: 184 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 243
Query: 181 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 240
CKE +E TTSTFCGTPEYLAPEVL K+PYDR VDWWCLGAVLYEML+GLPPFYS++ +
Sbjct: 244 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTA 303
Query: 241 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 300
+MY+NIL++PLQ+ T +A LL+ LL KD+ +RLG+K DF+EIK+HVFFS INWDDL
Sbjct: 304 EMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDL 363
Query: 301 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSY 357
+K++TPPFNPNV+GP DL+HFDPEFT+E V SIG +PD+V AS A+ AFLGFSY
Sbjct: 364 INKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 423
Query: 358 APEDDDIL 365
AP D L
Sbjct: 424 APPTDSFL 431
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 545 bits (1404), Expect = e-155
Identities = 261/368 (70%), Positives = 313/368 (85%), Gaps = 8/368 (2%)
Query: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
MN++P+ PSP INLGPS+NP+A+P+DF FLKVIGKG++GKVLLA+ K++ F
Sbjct: 83 MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 137
Query: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 120
YAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLVGL +SFQT +KLYFVLDY+NGGE
Sbjct: 138 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 197
Query: 121 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 180
LF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+YRDLKPENILLD QGH+VLTDFGL
Sbjct: 198 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 257
Query: 181 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 240
CKE +E TTSTFCGTPEYLAPEVL K+PYDR VDWWCLGAVLYEML+GLPPFYS++ +
Sbjct: 258 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTA 317
Query: 241 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 300
+MY+NIL++PLQ+ T +A LL+ LL KD+ +RLG+K DF+EIK+HVFFS INWDDL
Sbjct: 318 EMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDL 377
Query: 301 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSY 357
+K++TPPFNPNV+GP DL+HFDPEFT+E V SIG +PD+V AS A+ AFLGFSY
Sbjct: 378 INKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 437
Query: 358 APEDDDIL 365
AP D L
Sbjct: 438 APPTDSFL 445
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 545 bits (1404), Expect = e-155
Identities = 261/368 (70%), Positives = 313/368 (85%), Gaps = 8/368 (2%)
Query: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
MN++P+ PSP INLGPS+NP+A+P+DF FLKVIGKG++GKVLLA+ K++ F
Sbjct: 97 MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 151
Query: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 120
YAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLVGL +SFQT +KLYFVLDY+NGGE
Sbjct: 152 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 211
Query: 121 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 180
LF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+YRDLKPENILLD QGH+VLTDFGL
Sbjct: 212 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 271
Query: 181 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 240
CKE +E TTSTFCGTPEYLAPEVL K+PYDR VDWWCLGAVLYEML+GLPPFYS++ +
Sbjct: 272 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTA 331
Query: 241 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 300
+MY+NIL++PLQ+ T +A LL+ LL KD+ +RLG+K DF+EIK+HVFFS INWDDL
Sbjct: 332 EMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDL 391
Query: 301 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSY 357
+K++TPPFNPNV+GP DL+HFDPEFT+E V SIG +PD+V AS A+ AFLGFSY
Sbjct: 392 INKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 451
Query: 358 APEDDDIL 365
AP D L
Sbjct: 452 APPTDSFL 459
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 545 bits (1404), Expect = e-155
Identities = 261/368 (70%), Positives = 313/368 (85%), Gaps = 8/368 (2%)
Query: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
MN++P+ PSP INLGPS+NP+A+P+DF FLKVIGKG++GKVLLA+ K++ F
Sbjct: 164 MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 218
Query: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 120
YAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLVGL +SFQT +KLYFVLDY+NGGE
Sbjct: 219 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 278
Query: 121 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 180
LF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+YRDLKPENILLD QGH+VLTDFGL
Sbjct: 279 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 338
Query: 181 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 240
CKE +E TTSTFCGTPEYLAPEVL K+PYDR VDWWCLGAVLYEML+GLPPFYS++ +
Sbjct: 339 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTA 398
Query: 241 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 300
+MY+NIL++PLQ+ T +A LL+ LL KD+ +RLG+K DF+EIK+HVFFS INWDDL
Sbjct: 399 EMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDL 458
Query: 301 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSY 357
+K++TPPFNPNV+GP DL+HFDPEFT+E V SIG +PD+V AS A+ AFLGFSY
Sbjct: 459 INKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 518
Query: 358 APEDDDIL 365
AP D L
Sbjct: 519 APPTDSFL 526
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 513 bits (1321), Expect = e-145
Identities = 244/349 (69%), Positives = 289/349 (82%), Gaps = 3/349 (0%)
Query: 19 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 78
NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ
Sbjct: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
Query: 79 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 138
HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
Query: 139 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 198
YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP
Sbjct: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
Query: 199 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 258
EYLAPEV+RK+PYD VDWWCLGAVLYEML+GLPPFY +DV++MY+NILH+PL + G +
Sbjct: 326 EYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVS 385
Query: 259 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 318
+ A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D
Sbjct: 386 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 445
Query: 319 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 364
+++FD FT+E V S+ + D AS A AF+GFSYAP +D+
Sbjct: 446 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 494
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 513 bits (1321), Expect = e-145
Identities = 244/349 (69%), Positives = 289/349 (82%), Gaps = 3/349 (0%)
Query: 19 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 78
NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ
Sbjct: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
Query: 79 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 138
HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
Query: 139 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 198
YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP
Sbjct: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
Query: 199 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 258
EYLAPEV+RK+PYD VDWWCLGAVLYEML+GLPPFY +DV++MY+NILH+PL + G +
Sbjct: 326 EYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVS 385
Query: 259 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 318
+ A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D
Sbjct: 386 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 445
Query: 319 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 364
+++FD FT+E V S+ + D AS A AF+GFSYAP +D+
Sbjct: 446 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 494
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 434 bits (1117), Expect = e-122
Identities = 217/349 (62%), Positives = 259/349 (74%), Gaps = 35/349 (10%)
Query: 19 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 78
NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ
Sbjct: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
Query: 79 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 138
HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
Query: 139 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 198
YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP
Sbjct: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
Query: 199 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 258
E PPFY +DV++MY+NILH+PL + G +
Sbjct: 326 E--------------------------------PPFYCRDVAEMYDNILHKPLSLRPGVS 353
Query: 259 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 318
+ A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D
Sbjct: 354 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 413
Query: 319 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 364
+++FD FT+E V S+ + D AS A AF+GFSYAP +D+
Sbjct: 414 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 462
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 341 bits (875), Expect = 5e-94
Identities = 164/300 (54%), Positives = 211/300 (70%), Gaps = 2/300 (0%)
Query: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
DFD+LK++GKG +GKV+L + K+ G +YA+K+L+K+ I+ K E +H + E VL KN RH
Sbjct: 147 DFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRH 205
Query: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
PFL L+YSFQT ++L FV++YVNGGELFFHL RER F E R RFY AE+ SA+ YLHS
Sbjct: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
Query: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
I+YRDLK EN++LD GH+ +TDFGLCKEG+ T TFCGTPEYLAPEVL Y R
Sbjct: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGR 325
Query: 214 AVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQ 273
AVDWW LG V+YEM+ G PFY+QD +++E IL + ++ P + A LL LL KD
Sbjct: 326 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDP 385
Query: 274 RQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 332
+RL G D EI H FFS +NW D+Y K+L PPF P VT D ++FD EFT + ++
Sbjct: 386 NKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 341 bits (875), Expect = 5e-94
Identities = 164/300 (54%), Positives = 211/300 (70%), Gaps = 2/300 (0%)
Query: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
DFD+LK++GKG +GKV+L + K+ G +YA+K+L+K+ I+ K E +H + E VL KN RH
Sbjct: 147 DFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRH 205
Query: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
PFL L+YSFQT ++L FV++YVNGGELFFHL RER F E R RFY AE+ SA+ YLHS
Sbjct: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
Query: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
I+YRDLK EN++LD GH+ +TDFGLCKEG+ T TFCGTPEYLAPEVL Y R
Sbjct: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGR 325
Query: 214 AVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQ 273
AVDWW LG V+YEM+ G PFY+QD +++E IL + ++ P + A LL LL KD
Sbjct: 326 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDP 385
Query: 274 RQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 332
+RL G D EI H FFS +NW D+Y K+L PPF P VT D ++FD EFT + ++
Sbjct: 386 NKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 338 bits (866), Expect = 6e-93
Identities = 164/325 (50%), Positives = 220/325 (67%), Gaps = 3/325 (0%)
Query: 10 SPQPSRANGNINLGPS-ANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQK 68
SP S + + S A DFD+LK++GKG +GKV+L + K+ G +YA+K+L+K
Sbjct: 126 SPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRK 185
Query: 69 KSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRE 128
+ I+ K E +H + E VL +N RHPFL L+Y+FQT ++L FV++Y NGGELFFHL RE
Sbjct: 186 EVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRE 244
Query: 129 RRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPE 188
R F E RARFY AE+ SA+ YLHS +++YRD+K EN++LD GH+ +TDFGLCKEG+
Sbjct: 245 RVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDG 304
Query: 189 DTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH 248
T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD +++E IL
Sbjct: 305 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILM 364
Query: 249 QPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTP 307
+ ++ P + A LL LL KD +QRL G +D E+ H FF INW D+ K+L P
Sbjct: 365 EEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLP 424
Query: 308 PFNPNVTGPADLKHFDPEFTQEAVS 332
PF P VT D ++FD EFT ++++
Sbjct: 425 PFKPQVTSEVDTRYFDDEFTAQSIT 449
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 333 bits (854), Expect = 1e-91
Identities = 168/331 (50%), Positives = 224/331 (67%), Gaps = 8/331 (2%)
Query: 6 AGTPSPQPSRANGNINLGPSANPNAQPT--DFDFLKVIGKGNYGKVLLAKRKSDGAFYAV 63
+G+PS ++L A P + T +F++LK++GKG +GKV+L K K+ G +YA+
Sbjct: 122 SGSPSDNSGAEEMEVSL---AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
Query: 64 KVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF 123
K+L+K+ I+ K E +H + E VL +N RHPFL L+YSFQT ++L FV++Y NGGELFF
Sbjct: 179 KILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 124 HLQRERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCK 182
HL RER F E RARFY AE+ SA+ YLHS N++YRDLK EN++LD GH+ +TDFGLCK
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 183 EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQM 242
EG++ T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD ++
Sbjct: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
Query: 243 YENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLY 301
+E IL + ++ P A LL LL KD +QRL G D EI H FF+ I W +Y
Sbjct: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVY 417
Query: 302 HKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 332
K+L+PPF P VT D ++FD EFT + ++
Sbjct: 418 EKKLSPPFKPQVTSETDTRYFDEEFTAQMIT 448
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 333 bits (854), Expect = 1e-91
Identities = 168/331 (50%), Positives = 224/331 (67%), Gaps = 8/331 (2%)
Query: 6 AGTPSPQPSRANGNINLGPSANPNAQPT--DFDFLKVIGKGNYGKVLLAKRKSDGAFYAV 63
+G+PS ++L A P + T +F++LK++GKG +GKV+L K K+ G +YA+
Sbjct: 122 SGSPSDNSGAEEMEVSL---AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
Query: 64 KVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF 123
K+L+K+ I+ K E +H + E VL +N RHPFL L+YSFQT ++L FV++Y NGGELFF
Sbjct: 179 KILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 124 HLQRERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCK 182
HL RER F E RARFY AE+ SA+ YLHS N++YRDLK EN++LD GH+ +TDFGLCK
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 183 EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQM 242
EG++ T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD ++
Sbjct: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
Query: 243 YENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLY 301
+E IL + ++ P A LL LL KD +QRL G D EI H FF+ I W +Y
Sbjct: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVY 417
Query: 302 HKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 332
K+L+PPF P VT D ++FD EFT + ++
Sbjct: 418 EKKLSPPFKPQVTSETDTRYFDEEFTAQMIT 448
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 333 bits (854), Expect = 1e-91
Identities = 168/331 (50%), Positives = 224/331 (67%), Gaps = 8/331 (2%)
Query: 6 AGTPSPQPSRANGNINLGPSANPNAQPT--DFDFLKVIGKGNYGKVLLAKRKSDGAFYAV 63
+G+PS ++L A P + T +F++LK++GKG +GKV+L K K+ G +YA+
Sbjct: 122 SGSPSDNSGAEEMEVSL---AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
Query: 64 KVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF 123
K+L+K+ I+ K E +H + E VL +N RHPFL L+YSFQT ++L FV++Y NGGELFF
Sbjct: 179 KILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 124 HLQRERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCK 182
HL RER F E RARFY AE+ SA+ YLHS N++YRDLK EN++LD GH+ +TDFGLCK
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 183 EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQM 242
EG++ T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD ++
Sbjct: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
Query: 243 YENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLY 301
+E IL + ++ P A LL LL KD +QRL G D EI H FF+ I W +Y
Sbjct: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVY 417
Query: 302 HKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 332
K+L+PPF P VT D ++FD EFT + ++
Sbjct: 418 EKKLSPPFKPQVTSETDTRYFDEEFTAQMIT 448
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 302 bits (774), Expect = 3e-82
Identities = 147/318 (46%), Positives = 212/318 (66%), Gaps = 15/318 (4%)
Query: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
DFD L+VIG+G+Y KVLL + K YA+KV++K+ + ++ + E+ V + H
Sbjct: 253 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 312
Query: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
PFLVGL FQT +L+FV++YVNGG+L FH+QR+R+ E ARFY+AE++ A+ YLH
Sbjct: 313 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER 372
Query: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
IIYRDLK +N+LLD +GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 373 GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGF 432
Query: 214 AVDWWCLGAVLYEMLHGLPPF----YSQDVSQ-----MYENILHQPLQIPGGRTVAACDL 264
+VDWW LG +++EM+ G PF S + Q +++ IL + ++IP +V A +
Sbjct: 433 SVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASV 492
Query: 265 LQSLLHKDQRQRLG--SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHF 322
L+S L+KD ++RLG + F +I+ H FF ++WD + K++ PPF PN++G L +F
Sbjct: 493 LKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNF 552
Query: 323 DPEFTQEAVSKSIGCTPD 340
D +FT E V TPD
Sbjct: 553 DSQFTNEPVQ----LTPD 566
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 302 bits (774), Expect = 3e-82
Identities = 158/344 (45%), Positives = 221/344 (64%), Gaps = 13/344 (3%)
Query: 19 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSD---GAFYAVKVLQKKSILKK- 74
++N+GP P F+ L+V+GKG YGKV ++ G YA+KVL+K I++
Sbjct: 54 SVNVGPE---RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNA 110
Query: 75 KEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEP 134
K+ +H AER++L ++V+HPF+V L Y+FQT KLY +L+ ++GGELF HL+RE FLE
Sbjct: 111 KDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLED 169
Query: 135 RARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTF 194
A FY AE+ A+G+LHS IIYRDLKPENI+L QGH+ LTDFGLCKE + T TF
Sbjct: 170 TACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTF 229
Query: 195 CGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIP 254
CGT EY+APE+L + ++RAVDWW LGA++Y+ML G PPF +++ + + I+ L +P
Sbjct: 230 CGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALP 289
Query: 255 GGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 313
T A DL++ L ++ QR+ G D +++ H FF +NWDDL R+ PPF P +
Sbjct: 290 PYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCL 349
Query: 314 TGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
D+ FD FT++ S PD A S A+ AFLGF+Y
Sbjct: 350 QSEEDVSQFDTRFTRQTPVDS----PDDTALSESANQAFLGFTY 389
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 299 bits (765), Expect = 3e-81
Identities = 156/344 (45%), Positives = 222/344 (64%), Gaps = 13/344 (3%)
Query: 19 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKK- 74
++N GP +P F+ L+V+GKG YGKV ++ + G +A+KVL+K I++
Sbjct: 78 SVNRGPE---KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNA 134
Query: 75 KEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEP 134
K+ +H AER++L + V+HPF+V L Y+FQT KLY +L+Y++GGELF L+RE F+E
Sbjct: 135 KDTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMED 193
Query: 135 RARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTF 194
A FY AE++ A+G+LH IIYRDLKPENI+L+ QGHV LTDFGLCKE + T TF
Sbjct: 194 TACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTF 253
Query: 195 CGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIP 254
CGT EY+APE+L + ++RAVDWW LGA++Y+ML G PPF ++ + + IL L +P
Sbjct: 254 CGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLP 313
Query: 255 GGRTVAACDLLQSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 313
T A DLL+ LL ++ RLG+ D E++ H FF INW++L +++ PPF P +
Sbjct: 314 PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLL 373
Query: 314 TGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
D+ FD +FT++ S PD S A+ FLGF+Y
Sbjct: 374 QSEEDVSQFDSKFTRQTPVDS----PDDSTLSESANQVFLGFTY 413
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 295 bits (756), Expect = 3e-80
Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)
Query: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
DFD ++VIG+G+Y KVLL + K + YA+KV++K+ + ++ + E+ V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
PFLVGL FQT +L+ V++YVNGG+L FH+QR+R+ E ARFYAAE+ A+ +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
IIYRDLK +N+LLD GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 214 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 266
+VDWW LG +++EM+ G PF + D++ +++ IL +P++IP +V A +L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 267 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 324
L+KD ++RLG + F +IK+H FF I+WD L K+ PPF P +T L +FD
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 325 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 357
+FT E V TPD A S F GF Y
Sbjct: 368 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 397
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 295 bits (756), Expect = 3e-80
Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)
Query: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
DFD ++VIG+G+Y KVLL + K + YA+KV++K+ + ++ + E+ V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
PFLVGL FQT +L+ V++YVNGG+L FH+QR+R+ E ARFYAAE+ A+ +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
IIYRDLK +N+LLD GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 214 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 266
+VDWW LG +++EM+ G PF + D++ +++ IL +P++IP +V A +L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 267 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 324
L+KD ++RLG + F +IK+H FF I+WD L K+ PPF P +T L +FD
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 325 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 357
+FT E V TPD A S F GF Y
Sbjct: 368 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 397
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 295 bits (756), Expect = 3e-80
Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)
Query: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
DFD ++VIG+G+Y KVLL + K + YA+KV++K+ + ++ + E+ V + +
Sbjct: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
Query: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
PFLVGL FQT +L+ V++YVNGG+L FH+QR+R+ E ARFYAAE+ A+ +LH
Sbjct: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
Query: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
IIYRDLK +N+LLD GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
Query: 214 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 266
+VDWW LG +++EM+ G PF + D++ +++ IL +P++IP +V A +L+
Sbjct: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
Query: 267 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 324
L+KD ++RLG + F +IK+H FF I+WD L K+ PPF P +T L +FD
Sbjct: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
Query: 325 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 357
+FT E V TPD A S F GF Y
Sbjct: 551 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 580
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 292 bits (748), Expect = 3e-79
Identities = 150/348 (43%), Positives = 217/348 (62%), Gaps = 8/348 (2%)
Query: 17 NGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKE 76
NG + G + +F+F+KV+GKG++GKV+LA+ K YAVKVL+K IL+ +
Sbjct: 392 NGEVRQGQAKRLGLD--EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDD 449
Query: 77 QSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRA 136
M E+ +L +HP+L L FQT ++L+FV++YVNGG+L F +QR R+F EPR+
Sbjct: 450 VDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRS 509
Query: 137 RFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCG 196
RFYAAEV SA+ +LH +IYRDLK +NILLD +GH L DFG+CKEG+ TT+TFCG
Sbjct: 510 RFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCG 569
Query: 197 TPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGG 256
TP+Y+APE+L++ Y +VDWW LG ++YEM+ G PPF + + ++E+ILH + P
Sbjct: 570 TPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVW 629
Query: 257 RTVAACDLLQSLLHKDQRQRLG---SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 313
+ A +L++ + K+ +RLG S+ IK H FF I+W L K++ PPF P +
Sbjct: 630 LSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRI 689
Query: 314 TGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPED 361
D+ +FD +FT+E + + D F GFSY ED
Sbjct: 690 KTKRDVNNFDQDFTRE---EPVLTLVDEAIVKQINQEEFKGFSYFGED 734
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 289 bits (739), Expect = 3e-78
Identities = 145/318 (45%), Positives = 208/318 (65%), Gaps = 3/318 (0%)
Query: 14 SRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILK 73
S GN +G +++ +F+F++V+GKG++GKV+LA+ K G YAVKVL+K IL+
Sbjct: 335 SSKEGN-GIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQ 393
Query: 74 KKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLE 133
+ M E+ +L HPFL L FQTP++L+FV+++VNGG+L FH+Q+ RRF E
Sbjct: 394 DDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDE 453
Query: 134 PRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTST 193
RARFYAAE+ SA+ +LH IIYRDLK +N+LLD +GH L DFG+CKEG+ TT+T
Sbjct: 454 ARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTAT 513
Query: 194 FCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQI 253
FCGTP+Y+APE+L++ Y AVDWW +G +LYEML G PF +++ ++E IL+ +
Sbjct: 514 FCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVY 573
Query: 254 PGGRTVAACDLLQSLLHKDQRQRLGSKADFLE--IKNHVFFSPINWDDLYHKRLTPPFNP 311
P A +L+S + K+ RLGS E I H FF I+W L H+++ PPF P
Sbjct: 574 PTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 633
Query: 312 NVTGPADLKHFDPEFTQE 329
+ D+ +FDP+F +E
Sbjct: 634 RIKSREDVSNFDPDFIKE 651
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 282 bits (722), Expect = 3e-76
Identities = 148/367 (40%), Positives = 221/367 (60%), Gaps = 10/367 (2%)
Query: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
M S + PSP PS + ++ +DF FL V+GKG++GKV+LA+R+
Sbjct: 317 MGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDEL 376
Query: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP-----FLVGLRYSFQTPEKLYFVLDY 115
YA+K+L+K I++ + + E+ VL R P FL L +FQTP++LYFV++Y
Sbjct: 377 YAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEY 436
Query: 116 VNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVL 175
V GG+L +H+Q+ +F EP A FYAAE+A + +LH+ IIYRDLK +N++LD +GH+ +
Sbjct: 437 VTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKI 496
Query: 176 TDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFY 235
TDFG+CKE V P TT TFCGTP+Y+APE++ +PY ++VDWW G +LYEML G PPF
Sbjct: 497 TDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFD 556
Query: 236 SQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKAD-FLEIKNHVFFSP 294
+D ++++ I+ Q + P + A + + L K +RLGS D I+ H FF
Sbjct: 557 GEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRW 616
Query: 295 INWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLG 354
I+W+ L + PPF P G + ++FD FT+ A + + PD + +S + F G
Sbjct: 617 IDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRAAPALT---PPDRLVLASIDQADFQG 672
Query: 355 FSYAPED 361
F+Y D
Sbjct: 673 FTYVNPD 679
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 281 bits (720), Expect = 5e-76
Identities = 143/354 (40%), Positives = 213/354 (60%), Gaps = 7/354 (1%)
Query: 7 GTPSPQPSRANGNINLGPSANPNAQP-TDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKV 65
GT P+ N + N + TDF+FL V+GKG++GKV+L++RK YAVK+
Sbjct: 313 GTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKI 372
Query: 66 LQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHL 125
L+K +++ + M E+ VL + PFL L FQT ++LYFV++YVNGG+L +H+
Sbjct: 373 LKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI 432
Query: 126 QRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGV 185
Q+ RF EP A FYAAE+A + +L S IIYRDLK +N++LD +GH+ + DFG+CKE +
Sbjct: 433 QQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI 492
Query: 186 EPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYEN 245
TT TFCGTP+Y+APE++ +PY ++VDWW G +LYEML G PF +D +++++
Sbjct: 493 WDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS 552
Query: 246 ILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKAD-FLEIKNHVFFSPINWDDLYHKR 304
I+ + P + A + + L+ K +RLG + +IK H FF I+W+ L K
Sbjct: 553 IMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKE 612
Query: 305 LTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTP-DTVASSSGASSAFLGFSY 357
+ PP+ P D +FD EFT++ V TP D + + + F GFSY
Sbjct: 613 IQPPYKPKARDKRDTSNFDKEFTRQPVE----LTPTDKLFIMNLDQNEFAGFSY 662
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 281 bits (719), Expect = 7e-76
Identities = 153/346 (44%), Positives = 210/346 (60%), Gaps = 15/346 (4%)
Query: 25 SANPNAQPTDFDFLKVIGKGNYGKVLLAK---RKSDGAFYAVKVLQKKSILKKKEQSHIM 81
+ + A P+ F+ LKV+G+G++GKV L + R G YA+KVL KK+ LK +++
Sbjct: 61 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 119
Query: 82 AERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAA 141
ER +L +V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY A
Sbjct: 120 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 178
Query: 142 EVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYL 201
E+A + +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+
Sbjct: 179 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 238
Query: 202 APEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAA 261
APEV+ ++ + + DWW G +++EML G PF +D + IL L +P + A
Sbjct: 239 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 298
Query: 262 CDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLK 320
LL++L ++ RLGS D EIK HVF+S I+W+ LY + + PPF P V P D
Sbjct: 299 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 358
Query: 321 HFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAP----EDD 362
+FD EFT S G P S+GA F GFS+ EDD
Sbjct: 359 YFDTEFTSRTPKDSPGIPP-----SAGAHQLFRGFSFVATGLMEDD 399
Score = 124 bits (312), Expect = 1e-28
Identities = 83/253 (32%), Positives = 127/253 (50%), Gaps = 18/253 (7%)
Query: 39 KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVG 98
+ IG G+Y + K+ YAVKV+ K K++ S E +LL+ +HP ++
Sbjct: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS----KRDPSE---EIEILLRYGQHPNIIT 483
Query: 99 LRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYR 158
L+ + + +Y V + + GGEL + R++ F E A F + + YLHS +++R
Sbjct: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543
Query: 159 DLKPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRA 214
DLKP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD
Sbjct: 544 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 603
Query: 215 VDWWCLGAVLYEMLHGLPPFY---SQDVSQMYENILHQPLQIPGGR----TVAACDLLQS 267
D W LG +LY ML G PF S ++ I + GG + A DL+
Sbjct: 604 CDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSK 663
Query: 268 LLHKDQRQRLGSK 280
+LH D QRL +K
Sbjct: 664 MLHVDPHQRLTAK 676
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 281 bits (719), Expect = 7e-76
Identities = 153/346 (44%), Positives = 210/346 (60%), Gaps = 15/346 (4%)
Query: 25 SANPNAQPTDFDFLKVIGKGNYGKVLLAK---RKSDGAFYAVKVLQKKSILKKKEQSHIM 81
+ + A P+ F+ LKV+G+G++GKV L + R G YA+KVL KK+ LK +++
Sbjct: 52 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 110
Query: 82 AERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAA 141
ER +L +V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY A
Sbjct: 111 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 169
Query: 142 EVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYL 201
E+A + +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+
Sbjct: 170 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 229
Query: 202 APEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAA 261
APEV+ ++ + + DWW G +++EML G PF +D + IL L +P + A
Sbjct: 230 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 289
Query: 262 CDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLK 320
LL++L ++ RLGS D EIK HVF+S I+W+ LY + + PPF P V P D
Sbjct: 290 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 349
Query: 321 HFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAP----EDD 362
+FD EFT S G P S+GA F GFS+ EDD
Sbjct: 350 YFDTEFTSRTPKDSPGIPP-----SAGAHQLFRGFSFVATGLMEDD 390
Score = 124 bits (312), Expect = 1e-28
Identities = 83/253 (32%), Positives = 127/253 (50%), Gaps = 18/253 (7%)
Query: 39 KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVG 98
+ IG G+Y + K+ YAVKV+ K K++ S E +LL+ +HP ++
Sbjct: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS----KRDPSE---EIEILLRYGQHPNIIT 474
Query: 99 LRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYR 158
L+ + + +Y V + + GGEL + R++ F E A F + + YLHS +++R
Sbjct: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534
Query: 159 DLKPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRA 214
DLKP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD
Sbjct: 535 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 594
Query: 215 VDWWCLGAVLYEMLHGLPPFY---SQDVSQMYENILHQPLQIPGGR----TVAACDLLQS 267
D W LG +LY ML G PF S ++ I + GG + A DL+
Sbjct: 595 CDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSK 654
Query: 268 LLHKDQRQRLGSK 280
+LH D QRL +K
Sbjct: 655 MLHVDPHQRLTAK 667
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 279 bits (713), Expect = 3e-75
Identities = 142/356 (39%), Positives = 218/356 (61%), Gaps = 12/356 (3%)
Query: 5 PAGTP--SPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYA 62
PAG SP R + NL + TDF+FL V+GKG++GKV+LA RK YA
Sbjct: 312 PAGNKVISPSEDRKQPSNNLD-----RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYA 366
Query: 63 VKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELF 122
+K+L+K +++ + M E+ VL + PFL L FQT ++LYFV++YVNGG+L
Sbjct: 367 IKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLM 426
Query: 123 FHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCK 182
+H+Q+ +F EP+A FYAAE++ + +LH IIYRDLK +N++LD +GH+ + DFG+CK
Sbjct: 427 YHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCK 486
Query: 183 EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQM 242
E + TT TFCGTP+Y+APE++ +PY ++VDWW G +LYEML G PPF +D ++
Sbjct: 487 EHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDEL 546
Query: 243 YENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKAD-FLEIKNHVFFSPINWDDLY 301
+++I+ + P + A + + L+ K +RLG + +++ H FF I+W+ L
Sbjct: 547 FQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLE 606
Query: 302 HKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
++ + PPF P V G ++FD FT+ + + PD + ++ S F GFSY
Sbjct: 607 NREIQPPFKPKVCGKG-AENFDKFFTR---GQPVLTPPDQLVIANIDQSDFEGFSY 658
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 278 bits (711), Expect = 6e-75
Identities = 150/338 (44%), Positives = 207/338 (61%), Gaps = 11/338 (3%)
Query: 30 AQPTDFDFLKVIGKGNYGKVLLAKRKSDG---AFYAVKVLQKKSILKKKEQSHIMAERSV 86
A P+ F+ LKV+G+G++GKV L K+ S YA+KVL KK+ LK +++ ER +
Sbjct: 63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDI 121
Query: 87 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 146
L++ V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 122 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 147 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 206
+ +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+APEV+
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 207 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 266
+ + ++ DWW G +++EML G PF +D + IL L +P + A LL+
Sbjct: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
Query: 267 SLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPE 325
L ++ RLG+ D + EIK H FFS I+W+ LY + + PPF P P D +FDPE
Sbjct: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
Query: 326 FTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDD 363
FT + S G P S+ A F GFS+ D
Sbjct: 361 FTAKTPKDSPGIPP-----SANAHQLFRGFSFVAITSD 393
Score = 114 bits (286), Expect = 1e-25
Identities = 83/284 (29%), Positives = 137/284 (48%), Gaps = 24/284 (8%)
Query: 41 IGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLR 100
IG G+Y K+ +AVK++ K K++ + E +LL+ +HP ++ L+
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPTE---EIEILLRYGQHPNIITLK 480
Query: 101 YSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDL 160
+ + +Y V + + GGEL + R++ F E A + + YLH+ +++RDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
Query: 161 KPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVD 216
KP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD A D
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
Query: 217 WWCLGAVLYEMLHGLPPFYS---QDVSQMYENILHQPLQIPGGR----TVAACDLLQSLL 269
W LG +LY ML G PF + ++ I + GG + A DL+ +L
Sbjct: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
Query: 270 HKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 313
H D QRL + + H + ++WD L +L P++
Sbjct: 661 HVDPHQRLTAAL----VLRHPWI--VHWDQLPQYQLNRQDAPHL 698
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 278 bits (710), Expect = 7e-75
Identities = 149/332 (44%), Positives = 206/332 (62%), Gaps = 11/332 (3%)
Query: 30 AQPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKKKEQSHIMAERSV 86
A P+ F+ LKV+G+G+YGKV L ++ G YA+KVL KK+ LK +++ ER +
Sbjct: 62 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 120
Query: 87 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 146
L + V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 121 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
Query: 147 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 206
+ +LHSL IIYRDLKPENILLD +GH+ +TDFGL KE ++ + +FCGT EY+APEV+
Sbjct: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 239
Query: 207 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 266
+ + ++ DWW G +++EML G PF +D + IL L +P + A LL+
Sbjct: 240 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 299
Query: 267 SLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPE 325
+L ++ RLG+ D + EIK H FF I+W+ LY K + PPF P V P D HFDPE
Sbjct: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 359
Query: 326 FTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
FT + S G P S+ A F GFS+
Sbjct: 360 FTARTPTDSPGVPP-----SANAHHLFRGFSF 386
Score = 119 bits (298), Expect = 4e-27
Identities = 79/254 (31%), Positives = 125/254 (49%), Gaps = 18/254 (7%)
Query: 35 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 94
++ + IG G+Y K+ YAVK++ K K++ S E +LL+ +HP
Sbjct: 423 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS----KRDPSE---EIEILLRYGQHP 475
Query: 95 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 154
++ L+ + + +Y V++ + GGEL + R+R F E A + + YLHS
Sbjct: 476 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQG 535
Query: 155 IIYRDLKPENILLDCQG----HVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP 210
+++RDLKP NIL + + + DFG K+ T C T ++APEVL+++
Sbjct: 536 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 595
Query: 211 YDRAVDWWCLGAVLYEMLHGLPPFYS---QDVSQMYENILHQPLQIPGGR----TVAACD 263
YD A D W LG +LY ML G PF + ++ I + GG + AA D
Sbjct: 596 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 655
Query: 264 LLQSLLHKDQRQRL 277
++ +LH D QRL
Sbjct: 656 VVSKMLHVDPHQRL 669
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,802,674
Number of Sequences: 37866
Number of extensions: 759614
Number of successful extensions: 4252
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 709
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 1985
Number of HSP's gapped (non-prelim): 955
length of query: 367
length of database: 18,247,518
effective HSP length: 104
effective length of query: 263
effective length of database: 14,309,454
effective search space: 3763386402
effective search space used: 3763386402
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.