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Search of human proteins with 120431745
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|120431745 huntingtin-associated protein 1 isoform 4 [Homo
sapiens]
(594 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|120431745 huntingtin-associated protein 1 isoform 4 [Homo sap... 1181 0.0
gi|120431743 huntingtin-associated protein 1 isoform 3 [Homo sap... 1174 0.0
gi|120431738 huntingtin-associated protein 1 isoform 2 [Homo sap... 1167 0.0
gi|45359873 OGT(O-Glc-NAc transferase)-interacting protein 106 K... 131 2e-30
gi|111074532 OGT(O-Glc-NAc transferase)-interacting protein 106 ... 127 4e-29
gi|188497667 trafficking protein, kinesin binding 2 [Homo sapiens] 115 1e-25
gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 65 2e-10
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 63 7e-10
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 59 1e-08
gi|38569484 kinesin family member 21A [Homo sapiens] 59 1e-08
gi|221139761 zinc finger protein 853 [Homo sapiens] 59 2e-08
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 57 4e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 57 4e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 57 4e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 57 4e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 57 4e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 57 4e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 57 4e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 57 4e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 57 4e-08
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 57 6e-08
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 57 6e-08
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)... 57 6e-08
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 56 8e-08
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 56 1e-07
gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo sap... 56 1e-07
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 55 1e-07
gi|148746195 trichohyalin [Homo sapiens] 55 1e-07
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 55 2e-07
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 55 2e-07
>gi|120431745 huntingtin-associated protein 1 isoform 4 [Homo
sapiens]
Length = 594
Score = 1181 bits (3056), Expect = 0.0
Identities = 594/594 (100%), Positives = 594/594 (100%)
Query: 1 MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF 60
MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF
Sbjct: 1 MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF 60
Query: 61 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR 120
LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR
Sbjct: 61 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR 120
Query: 121 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL 180
GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL
Sbjct: 121 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL 180
Query: 181 LEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEIL 240
LEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEIL
Sbjct: 181 LEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEIL 240
Query: 241 YLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLI 300
YLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLI
Sbjct: 241 YLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLI 300
Query: 301 SQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS 360
SQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS
Sbjct: 301 SQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS 360
Query: 361 QQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRR 420
QQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRR
Sbjct: 361 QQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRR 420
Query: 421 MISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPA 480
MISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPA
Sbjct: 421 MISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPA 480
Query: 481 EEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVTSALEASGL 540
EEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVTSALEASGL
Sbjct: 481 EEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVTSALEASGL 540
Query: 541 GPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGECPHGALPAASRTSCRSSCR 594
GPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGECPHGALPAASRTSCRSSCR
Sbjct: 541 GPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGECPHGALPAASRTSCRSSCR 594
>gi|120431743 huntingtin-associated protein 1 isoform 3 [Homo
sapiens]
Length = 602
Score = 1174 bits (3037), Expect = 0.0
Identities = 594/602 (98%), Positives = 594/602 (98%), Gaps = 8/602 (1%)
Query: 1 MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF 60
MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF
Sbjct: 1 MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF 60
Query: 61 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR 120
LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR
Sbjct: 61 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR 120
Query: 121 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL 180
GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL
Sbjct: 121 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL 180
Query: 181 LEE--------LLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALL 232
LEE LLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALL
Sbjct: 181 LEEVCTAFLIQLLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALL 240
Query: 233 GSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH 292
GSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH
Sbjct: 241 GSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH 300
Query: 293 PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILEC 352
PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILEC
Sbjct: 301 PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILEC 360
Query: 353 VEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAE 412
VEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAE
Sbjct: 361 VEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAE 420
Query: 413 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM 472
ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM
Sbjct: 421 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM 480
Query: 473 RGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVT 532
RGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVT
Sbjct: 481 RGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVT 540
Query: 533 SALEASGLGPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGECPHGALPAASRTSCRSS 592
SALEASGLGPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGECPHGALPAASRTSCRSS
Sbjct: 541 SALEASGLGPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGECPHGALPAASRTSCRSS 600
Query: 593 CR 594
CR
Sbjct: 601 CR 602
>gi|120431738 huntingtin-associated protein 1 isoform 2 [Homo
sapiens]
Length = 619
Score = 1167 bits (3020), Expect = 0.0
Identities = 594/619 (95%), Positives = 594/619 (95%), Gaps = 25/619 (4%)
Query: 1 MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF 60
MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF
Sbjct: 1 MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF 60
Query: 61 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR 120
LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR
Sbjct: 61 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR 120
Query: 121 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL 180
GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL
Sbjct: 121 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL 180
Query: 181 LEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEIL 240
LEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEIL
Sbjct: 181 LEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEIL 240
Query: 241 YLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLI 300
YLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLI
Sbjct: 241 YLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLI 300
Query: 301 SQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS 360
SQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS
Sbjct: 301 SQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS 360
Query: 361 QQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRM-------------------- 400
QQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRM
Sbjct: 361 QQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMYGAETEKLQKQLASEKEIQM 420
Query: 401 -----ETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQ 455
ETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQ
Sbjct: 421 QLQEEETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQ 480
Query: 456 VRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGW 515
VRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGW
Sbjct: 481 VRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGW 540
Query: 516 EEVELELDEATRMNVVTSALEASGLGPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGE 575
EEVELELDEATRMNVVTSALEASGLGPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGE
Sbjct: 541 EEVELELDEATRMNVVTSALEASGLGPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGE 600
Query: 576 CPHGALPAASRTSCRSSCR 594
CPHGALPAASRTSCRSSCR
Sbjct: 601 CPHGALPAASRTSCRSSCR 619
>gi|45359873 OGT(O-Glc-NAc transferase)-interacting protein 106 KDa
isoform 2 [Homo sapiens]
Length = 686
Score = 131 bits (329), Expect = 2e-30
Identities = 88/250 (35%), Positives = 133/250 (53%), Gaps = 47/250 (18%)
Query: 154 LEEALCPNLPPPVKKITQEDVKVMLYLLEELLPPVWESVTYGMVLQRERDLNTAARIGQS 213
LEE LC + K T D+ + LLEE +ERDL AARIGQS
Sbjct: 35 LEEVLCAERVGQMTK-TYNDIDAVTRLLEE----------------KERDLELAARIGQS 77
Query: 214 LVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEK 273
L+K+N L E N LE + +EE+ LRH+++++DELLQ Y+ + EE E E
Sbjct: 78 LLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPES------ 131
Query: 274 EAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLRE 333
C P ++ + Q++ L++LQ+KL+ LEEEN LR
Sbjct: 132 -------------------VCSTPLKRNESSSSVQNYF-HLDSLQKKLKDLEEENVVLRS 171
Query: 334 EASQLD----TLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQA 389
EASQL T E++EQ L+ +CV++ +A+ Q+A +SE L + E+ RQQ+E+ L +
Sbjct: 172 EASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLS 231
Query: 390 QVLKLQQRCR 399
Q++ LQ++ +
Sbjct: 232 QIVDLQKKAK 241
>gi|111074532 OGT(O-Glc-NAc transferase)-interacting protein 106 KDa
isoform 1 [Homo sapiens]
Length = 953
Score = 127 bits (318), Expect = 4e-29
Identities = 76/205 (37%), Positives = 119/205 (58%), Gaps = 30/205 (14%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSD 258
++ERDL AARIGQSL+K+N L E N LE + +EE+ LRH+++++DELLQ Y+
Sbjct: 121 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS 180
Query: 259 SDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQ 318
+ EE E E C P ++ + Q++ L++LQ
Sbjct: 181 AAEESEPES-------------------------VCSTPLKRNESSSSVQNYF-HLDSLQ 214
Query: 319 EKLRLLEEENHQLREEASQLD----TLEDEEQMLILECVEQFSEASQQMAELSEVLVLRL 374
+KL+ LEEEN LR EASQL T E++EQ L+ +CV++ +A+ Q+A +SE L +
Sbjct: 215 KKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKT 274
Query: 375 ENYERQQQEVARLQAQVLKLQQRCR 399
E+ RQQ+E+ L +Q++ LQ++ +
Sbjct: 275 EDAARQQEEITHLLSQIVDLQKKAK 299
>gi|188497667 trafficking protein, kinesin binding 2 [Homo sapiens]
Length = 914
Score = 115 bits (287), Expect = 1e-25
Identities = 76/244 (31%), Positives = 129/244 (52%), Gaps = 31/244 (12%)
Query: 196 MVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQL 255
++ +R+RDL AARIGQ+L+K+N VL E+N LE LG A +++ L+H++ +DELL++
Sbjct: 118 LLAERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQVNQLQHELCKKDELLRI 177
Query: 256 YSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLE 315
S + EE E + C P ++ L Q QLE
Sbjct: 178 VSIASEESETDSS-------------------------CSTPLRFNESFSLSQ-GLLQLE 211
Query: 316 ALQEKLRLLEEENHQLREEASQLD----TLEDEEQMLILECVEQFSEASQQMAELSEVLV 371
LQEKL+ LEEEN LR +A + T E++EQ L+ +CV++ E + QM+ ++E L
Sbjct: 212 MLQEKLKELEEENMALRSKACHIKTETVTYEEKEQQLVSDCVKELRETNAQMSRMTEELS 271
Query: 372 LRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVY-FME 430
+ + R Q+E++ L +Q++ LQ + + + + L + +R ++ ++ +
Sbjct: 272 GKSDELIRYQEELSSLLSQIVDLQHKLKEHVIEKEELKLHLQASKDAQRQLTMELHELQD 331
Query: 431 RNYE 434
RN E
Sbjct: 332 RNME 335
>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
Length = 573
Score = 64.7 bits (156), Expect = 2e-10
Identities = 79/350 (22%), Positives = 149/350 (42%), Gaps = 26/350 (7%)
Query: 186 PPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQ 245
PP + ++ Q+E+DL AAR+G++L+++N + + ++ L E + +H+
Sbjct: 92 PPSQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHE 151
Query: 246 VNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEAL 305
+ R E + + E E E + K+ ++E E ++ A + +S++
Sbjct: 152 LRRRFE----NREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQ-- 205
Query: 306 LHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAE 365
+Q QL E R L + H LRE+ + ++ ++ + + + S + E
Sbjct: 206 -NQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRE 264
Query: 366 LSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETL-AEELRTSLRRM-IS 423
L L LE + Q V LQ +VL L+++ + L Q L +E+R S R++ +
Sbjct: 265 LEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVK 324
Query: 424 DPVYFMERNYEMPRGDTSSLRYDFRYS-------EDREQVR--GFEAEEGLMLAADIMRG 474
ER+ + ++SL + S ++REQ+R +EA + +RG
Sbjct: 325 VEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRG 384
Query: 475 EDFTPA-----EEFVPQEELGAAKKVPA---EEGVMEEAELVSEETEGWE 516
D + E +AK VPA + E L+ +G E
Sbjct: 385 NDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGME 434
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 63.2 bits (152), Expect = 7e-10
Identities = 57/272 (20%), Positives = 121/272 (44%), Gaps = 13/272 (4%)
Query: 200 RERDLNTAARIGQSLVKQNSVLMEENS--KLEALLGSAKEEILYLRHQVNLRDELL---- 253
RE++ + GQ ++ V +E + E +G +E++ Q+ ++E +
Sbjct: 167 REQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQE 226
Query: 254 -QLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCP 312
Q+ ++ E EE+ ++++E ++QEE+ +++ Q + + ++ L +
Sbjct: 227 EQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTE 286
Query: 313 QLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVL 372
Q E E+ + E+ Q+RE+ Q+ E EEQM E EQ + +QM E E +
Sbjct: 287 QEEQTGEQEEQMREQEEQMREQEEQM--REQEEQM--REQEEQMGKQEEQMWEQKEQMWE 342
Query: 373 RLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERN 432
+ E +Q++++ + Q+ K +++ R + E++R +M E+
Sbjct: 343 QKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQ--MRKQEEQMRKQEEQMRKQEEQMGEQK 400
Query: 433 YEMPRGDTSSLRYDFRYSEDREQVRGFEAEEG 464
+M + + E +EQ+R E G
Sbjct: 401 EQMGEQKEQMREQEEQMGEQKEQMRKQEEHMG 432
Score = 58.9 bits (141), Expect = 1e-08
Identities = 76/330 (23%), Positives = 148/330 (44%), Gaps = 40/330 (12%)
Query: 200 RERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVN-LRDELLQLYSD 258
RE++ + GQ + +Q + E+ ++ G +E+ +R Q +R++ Q+
Sbjct: 139 REQEGQVREQEGQ-VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQ 197
Query: 259 SDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQ 318
+ E EE+ E++E ++QEE+ E++ Q ++ QE + + Q E +Q
Sbjct: 198 EGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRK--QEEQMGEQEEQVQK----QEEQVQ 251
Query: 319 EKLRLLEEENHQLREEASQLDTLEDEEQML----ILECVEQFSEASQQMAELSEVLVLRL 374
++ + ++ Q+RE+ Q+ E EEQML E EQ E +QM E E +
Sbjct: 252 KQEEQMRKQEEQMREQEEQM--REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQM---- 305
Query: 375 ENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYE 434
R+Q+E R Q + ++ Q E G QE E++ +M ++ +
Sbjct: 306 ----REQEEQMREQEEQMREQ-----EEQMGKQE---EQMWEQKEQMWEQKEQMWKQEEQ 353
Query: 435 MPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKK 494
M + + + + + EQ+R + EE + + MR ++ E+ +E++G K
Sbjct: 354 MGEQEEQMQKQEEQVRKQEEQMR--KQEEQMRKQEEQMRKQEEQMGEQ---KEQMGEQK- 407
Query: 495 VPAEEGVMEEAELVSEETEGWEEVELELDE 524
E + E+ E + E+ E + E + E
Sbjct: 408 ----EQMREQEEQMGEQKEQMRKQEEHMGE 433
Score = 42.4 bits (98), Expect = 0.001
Identities = 38/174 (21%), Positives = 84/174 (48%), Gaps = 19/174 (10%)
Query: 216 KQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEA 275
++ + +E ++ E G +E++ Q+ ++E ++ E++E E+EE+
Sbjct: 275 EEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMR------EQEEQMREQEEQMGK 328
Query: 276 EEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEE----NHQL 331
+EEQ E+ E+ + ++ QE + + Q++ +E++R EE+ Q+
Sbjct: 329 QEEQMWEQKEQMWE-----QKEQMWKQEEQMGEQE-EQMQKQEEQVRKQEEQMRKQEEQM 382
Query: 332 REEASQLDTLED---EEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQ 382
R++ Q+ E+ E++ + E EQ E +QM E E + + E+ Q++
Sbjct: 383 RKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 35.0 bits (79), Expect = 0.19
Identities = 30/149 (20%), Positives = 70/149 (46%), Gaps = 8/149 (5%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSD 258
Q E++ T + Q ++ + +E E ++E + + + ++ Q++
Sbjct: 284 QTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQ 343
Query: 259 SDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQ 318
++ + EE+ E++E ++QEE+ +++ Q ++ QE + + Q E +
Sbjct: 344 KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRK--QEEQMRKQEEQMRK----QEEQMG 397
Query: 319 EKLRLLEEENHQLREEASQLDTLEDEEQM 347
E+ + E+ Q+RE+ Q+ E +EQM
Sbjct: 398 EQKEQMGEQKEQMREQEEQMG--EQKEQM 424
Score = 33.5 bits (75), Expect = 0.57
Identities = 62/263 (23%), Positives = 102/263 (38%), Gaps = 24/263 (9%)
Query: 265 DEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLL 324
+EE +E+ E +EE + E E+ H + + + + + PQ ++E+ +
Sbjct: 6 NEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKI----PLPQEGQVREQEGQV 61
Query: 325 EEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQ-E 383
E+ Q+RE+ Q+ E++ + E Q E Q+ E E V E R+Q+ +
Sbjct: 62 REQEGQVREQEGQV----REQEGQVREQEGQVREQEGQVRE-QEGQVREQEGQVREQEGQ 116
Query: 384 VARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSL 443
V + QV + + + R QE E +R V E G
Sbjct: 117 VREQEGQVREQEGQVRE------QEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQ 169
Query: 444 RYDFRYSED--REQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGV 501
R E REQ +EG M + GE E+ QEE +K + G
Sbjct: 170 EGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQ---EEQMGEQEE--QMQKQEEQMGE 224
Query: 502 MEEAELVSEETEGWEEVELELDE 524
EE EE G +E +++ E
Sbjct: 225 QEEQMRKQEEQMGEQEEQVQKQE 247
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 58.9 bits (141), Expect = 1e-08
Identities = 67/318 (21%), Positives = 141/318 (44%), Gaps = 27/318 (8%)
Query: 212 QSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEE 271
QS+ + +EEN L +E++ ++ R+E +Q + E E++ +E
Sbjct: 263 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQE 322
Query: 272 EKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHH--CPQLEALQEKLRLLEEENH 329
E E+E++ EE + K+ E +H+ Q E QE+ ++ E+E
Sbjct: 323 EMMWEKEEKMRRQEEMMWEKE----EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR 378
Query: 330 QLREEA--SQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVARL 387
Q +E Q + + ++E+ I E E E ++M E E + + E + Q++++ R
Sbjct: 379 QEQEAKMWRQEEKIREQEEK-IREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQ 437
Query: 388 QAQVLKLQQRCRMETLPGFQETLAEE---LRTSLRRMISDPVYFMERNYEMPRGDTSSLR 444
+ ++ + +++ R + +E + E+ ++ +M E+ +M + R
Sbjct: 438 EEKIREQEKKIREQ-----EEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRR 492
Query: 445 YDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEE 504
+ + E +++R E EE + ++M+ ++ E+ QEE K EE + E+
Sbjct: 493 QEEKIREQEKKIR--EQEEKIREQEEMMQEQE----EKMWEQEE----KMCEQEEKMQEQ 542
Query: 505 AELVSEETEGWEEVELEL 522
E + + E E E+ L
Sbjct: 543 EEKMRRQEEKMREQEVRL 560
Score = 52.8 bits (125), Expect = 9e-07
Identities = 84/370 (22%), Positives = 155/370 (41%), Gaps = 42/370 (11%)
Query: 169 ITQEDVKVMLYLLEELLPPVW--ESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENS 226
IT E++K L+E L V +S V + +R L A L+ L E
Sbjct: 202 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERA-----KLLLPQQQLQAEAD 256
Query: 227 KLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEE 286
L L S ++ + L + L Q + E++ +E EEK E+E++ E EE
Sbjct: 257 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEE 316
Query: 287 DLQCAHPC---DAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLED 343
++ K+ QE ++ + +EK+R LEE+ H+ + Q + ++
Sbjct: 317 KMRRQEEMMWEKEEKMRRQEEMMWEK--------EEKIRELEEKMHEQEKIREQEEKRQE 368
Query: 344 EEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETL 403
EE++ Q+ + E + R E R+Q+E R Q ++++ Q+ E
Sbjct: 369 EEKI-----------REQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQE 417
Query: 404 PGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEE 463
E EE++ +M E+ ++ R +R +++E+ G +E
Sbjct: 418 EKMWEQ-EEEMQEQEEKMRRQEEKIREQEKKI-REQEEKIREQEEMMQEQEEKMG--EQE 473
Query: 464 GLMLAADIM---RGEDFTPAEEFVPQEELGAAKKV-PAEEGVMEEAELVSEETEG-WEEV 518
G M + + E EE + ++E KK+ EE + E+ E++ E+ E WE+
Sbjct: 474 GKMCEQEAKMQEQEEKMRRQEEKIREQE----KKIREQEEKIREQEEMMQEQEEKMWEQE 529
Query: 519 ELELDEATRM 528
E ++ +M
Sbjct: 530 EKMCEQEEKM 539
Score = 52.0 bits (123), Expect = 2e-06
Identities = 43/196 (21%), Positives = 94/196 (47%), Gaps = 24/196 (12%)
Query: 223 EENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEE---- 278
E+ + EA + +E+I ++ ++E++Q + E E++ E+EE+ E+E
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435
Query: 279 -QEEEEAEEDLQCAHPCDAPKLISQEALLHQHH----------CPQLEALQEKLRLLEEE 327
QEE+ E++ + K+ QE ++ + C Q +QE+ + +
Sbjct: 436 RQEEKIREQEKKIRE--QEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQ 493
Query: 328 NHQLREEASQLDTLED---EEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEV 384
++RE+ ++ E+ E++ ++ E E+ E ++M E E + + E RQ++++
Sbjct: 494 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 553
Query: 385 ----ARLQAQVLKLQQ 396
RL+ Q K+Q+
Sbjct: 554 REQEVRLRQQEEKMQE 569
Score = 51.2 bits (121), Expect = 3e-06
Identities = 48/252 (19%), Positives = 117/252 (46%), Gaps = 19/252 (7%)
Query: 212 QSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEE-- 269
+ + +Q ++ E+ K+ L EE ++ + ++ ++E Q E+++ +E+E
Sbjct: 330 EKMRRQEEMMWEKEEKIREL-----EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 384
Query: 270 ---EEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEE 326
+EEK E+E++ E EE +Q K+ QE + + +++ +EK+R EE
Sbjct: 385 MWRQEEKIREQEEKIREQEEMMQEQEE----KMGEQEEKMWEQE-EEMQEQEEKMRRQEE 439
Query: 327 ENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVAR 386
+ + ++ + + E++ ++ E E+ E +M E + + E RQ++++
Sbjct: 440 KIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE 499
Query: 387 LQAQVLKLQQRCR-METLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRY 445
+ ++ + +++ R E + QE E++ +M E+ +M R +
Sbjct: 500 QEKKIREQEEKIREQEEMMQEQE---EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQ 556
Query: 446 DFRYSEDREQVR 457
+ R + E+++
Sbjct: 557 EVRLRQQEEKMQ 568
>gi|38569484 kinesin family member 21A [Homo sapiens]
Length = 1661
Score = 58.9 bits (141), Expect = 1e-08
Identities = 50/183 (27%), Positives = 90/183 (49%), Gaps = 6/183 (3%)
Query: 243 RHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQ 302
R L E Q SD ++E+E+EEEEE++ + E +E ++E D + + D I+
Sbjct: 581 RENNELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQADLAN-ITC 639
Query: 303 EALLHQHHCPQLEALQEKLRLLE---EENHQLREEASQLDTLEDEEQMLILECVEQFSEA 359
E + Q +LE Q++L+ L+ EE + + + LE ++ + L VE +SE
Sbjct: 640 EIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEE 699
Query: 360 SQQMAELSEVLVLRLENYERQQQEVARLQ-AQVLKLQQRCRMETLPGFQETLAEELRTSL 418
+ L+ N E Q+ + A+ + A++LK Q + + L Q+ + E +T +
Sbjct: 700 KAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQ-LKKLQQDVMEMKKTKV 758
Query: 419 RRM 421
R M
Sbjct: 759 RLM 761
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 58.5 bits (140), Expect = 2e-08
Identities = 64/286 (22%), Positives = 133/286 (46%), Gaps = 19/286 (6%)
Query: 244 HQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQE 303
H L+ EL ++ + + +E++ ++ +E+ + ++A+E + + ++
Sbjct: 142 HHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQ 201
Query: 304 ALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSE--ASQ 361
LL Q Q E LQ++ L ++E Q ++ Q + L+ ++Q+L+L+ Q + Q
Sbjct: 202 QLLQQ----QQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQ 257
Query: 362 QMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRM 421
Q A+L + L LE + Q Q+ LQ Q +LQQ+ + + L QE L ++ L+
Sbjct: 258 QQAQLQQQL---LEQQQAQLQQQLLLQQQE-QLQQQQQQQLLQQQQEQLQQQ---QLQPP 310
Query: 422 ISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEE-----GLMLAADIMRGED 476
+P E E+ D S + + ++ E+ + E ++ L L ++ + E
Sbjct: 311 PLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQLEQ 370
Query: 477 FTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELEL 522
++ +++ + P E G ++ E+ E T E++LEL
Sbjct: 371 QLEQQQQQLEQQEVQLELTPVELGAQQQ-EVQLELTPVQPELQLEL 415
Score = 50.4 bits (119), Expect = 4e-06
Identities = 47/259 (18%), Positives = 120/259 (46%), Gaps = 21/259 (8%)
Query: 266 EEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLE 325
E +++ +++ +++ + + E+ H P+L L+HQ Q + +QE+ RL +
Sbjct: 117 ELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPEL----QLMHQQQQLQPQQVQEQQRLQQ 172
Query: 326 EENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVA 385
++ ++A + L+ +EQ + + V++ QQ +L + +L+ + + QQQ+
Sbjct: 173 QQEQLQTQQAQEQQVLQQQEQ--LQQQVQEQQLLQQQQEQLQQQQLLQ-QQEQLQQQQFQ 229
Query: 386 RLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRY 445
+ Q Q+ + QQ ++ Q+ L ++ + L++ + + + L+
Sbjct: 230 QQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQ-------------QQAQLQQ 276
Query: 446 DFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEA 505
+ +EQ++ + ++ L + ++ + P +EE + +P + G +E
Sbjct: 277 QL-LLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQEL 335
Query: 506 ELVSEETEGWEEVELELDE 524
E +E E +E+E + ++
Sbjct: 336 EQQRQELERQQELERQQEQ 354
Score = 45.1 bits (105), Expect = 2e-04
Identities = 49/188 (26%), Positives = 85/188 (45%), Gaps = 23/188 (12%)
Query: 196 MVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEA-LLGSAKEEILYLRHQVNLRDELLQ 254
++LQ++ L Q Q +L ++ ++L+ LL +E++ + Q L+ + Q
Sbjct: 242 LLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQ 301
Query: 255 LYSDSDEEDEDEEEEEEEKEAE-------EEQEEEEAEEDLQCAHPCDAPKLISQEALLH 307
L + E EEEEE E E EQE E+ ++L+ Q+ L
Sbjct: 302 LQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELE-----------RQQELER 350
Query: 308 QHHCPQLE-ALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAEL 366
Q QL+ LQE+L+ LE+ QL ++ QL+ E + ++ +E Q E ++ +
Sbjct: 351 QQEQRQLQLKLQEELQQLEQ---QLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPV 407
Query: 367 SEVLVLRL 374
L L L
Sbjct: 408 QPELQLEL 415
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 57.4 bits (137), Expect = 4e-08
Identities = 35/98 (35%), Positives = 57/98 (58%), Gaps = 7/98 (7%)
Query: 248 LRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLH 307
L ++L + +S +E+E+EEEEEEE+E EEE+EEE+ EE+ + D + +E
Sbjct: 874 LEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEE-----DEEEYFEEEEEEE 928
Query: 308 QHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEE 345
+ + E +E+ L EEE + EE +L+ +ED E
Sbjct: 929 EEFEEEFE--EEEGELEEEEEEEDEEEEEELEEVEDLE 964
Score = 38.1 bits (87), Expect = 0.023
Identities = 20/63 (31%), Positives = 34/63 (53%)
Query: 223 EENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEE 282
EE + E ++E Y + +E + + + + E E+EEEEE+E+E EE +E E
Sbjct: 902 EEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVE 961
Query: 283 EAE 285
+ E
Sbjct: 962 DLE 964
Score = 37.0 bits (84), Expect = 0.051
Identities = 22/65 (33%), Positives = 34/65 (52%)
Query: 223 EENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEE 282
EE + E +EE + +E + + +EE E+E EEEE + EEE+EE+
Sbjct: 891 EEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEED 950
Query: 283 EAEED 287
E EE+
Sbjct: 951 EEEEE 955
Score = 30.8 bits (68), Expect = 3.7
Identities = 27/94 (28%), Positives = 46/94 (48%), Gaps = 7/94 (7%)
Query: 275 AEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKL-RLLEEENHQLRE 333
+ +E+EEEE EE+ + + + +E + + + E +E+ EEE +L E
Sbjct: 885 SSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEE 944
Query: 334 EASQLDTLEDEEQMLILECVE--QFSEASQQMAE 365
E + D E+EE LE VE +F A ++ E
Sbjct: 945 EEEEEDEEEEEE----LEEVEDLEFGTAGGEVEE 974
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 57.4 bits (137), Expect = 4e-08
Identities = 71/309 (22%), Positives = 130/309 (42%), Gaps = 35/309 (11%)
Query: 237 EEILYLRHQVNLRDE----LLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH 292
EEI H+ L + L+Q ++ + + E E AE E+E+E+ +++ +
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470
Query: 293 -PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILE 351
+ + + QE LL + Q L EK LL+ E + +E ++L+ L +E +
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQDEVAKAQQ 2529
Query: 352 CVEQFSEASQQMAELSEVLVLRLENYERQQQE----VARLQAQVLKLQQRCRMETLPGFQ 407
E+ QQM + + LV +E R+Q E V R Q ++ +L+Q+ R + +
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ-----E 2584
Query: 408 ETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLML 467
E LAEE + + + + +E + R +SE+ A + L
Sbjct: 2585 ELLAEE-----NQRLREQLQLLEEQH----------RAALAHSEE-VTASQVAATKTLPN 2628
Query: 468 AADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATR 527
D + G PA E P+ ++ + + + E L +EE + + +DE R
Sbjct: 2629 GRDALDG----PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2684
Query: 528 MNVVTSALE 536
V L+
Sbjct: 2685 REDVRHYLQ 2693
Score = 45.4 bits (106), Expect = 1e-04
Identities = 66/327 (20%), Positives = 138/327 (42%), Gaps = 36/327 (11%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E DL + + ++K+ ++E ++L+A E L+ Q EL Q +
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-------EAELLQQQ----KELAQEQARRL 2346
Query: 261 EEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEK 320
+ED+++ ++ +E + Q EAE Q +A +L + A + + E Q
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406
Query: 321 LRLLEEENHQL-------REEASQLDTLE------DEEQMLILECVEQFSEASQQMAELS 367
+ EE +L +E+ + + TLE D + + E + + +++ + +
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2466
Query: 368 EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVY 427
++L L+ E + QQE + Q L+ ++L +E E+ + L ++ D V
Sbjct: 2467 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVA 2525
Query: 428 FMERNYEMPRGDTSSL---RYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFV 484
++ E + + R S + + R EAEEG+ + E+ E+
Sbjct: 2526 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR-----RKQEELQQLEQQR 2580
Query: 485 PQEELGAAKKVPAEEGVMEEAELVSEE 511
Q+E A++ + + E+ +L+ E+
Sbjct: 2581 RQQEELLAEE---NQRLREQLQLLEEQ 2604
Score = 44.3 bits (103), Expect = 3e-04
Identities = 63/269 (23%), Positives = 113/269 (42%), Gaps = 22/269 (8%)
Query: 217 QNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAE 276
+ +L + S +A G A+ E+ R + N D L S E+ E E + + AE
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEAARQRQLAAE 1978
Query: 277 EEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENH------- 329
EE+ EAEE +Q + + ++A L + +L+A E+ R L E
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQL 2036
Query: 330 QLREEASQ--LDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYER--QQQEVA 385
QL +EA+Q L E + + ++ + QQ + + L E R ++ E A
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 386 RLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPR---GDTSS 442
R+QA+ Q R ++E +++ E+ + + + E E R + ++
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156
Query: 443 LRYDFRYSEDREQVRGFEAEEGLMLAADI 471
LR + E+ + F AE+ L A +
Sbjct: 2157 LRQKQAADAEMEKHKKF-AEQTLRQKAQV 2184
Score = 44.3 bits (103), Expect = 3e-04
Identities = 84/374 (22%), Positives = 148/374 (39%), Gaps = 46/374 (12%)
Query: 200 RERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDS 259
RER +AR Q + ++ K A KE+ L Q L+ E L
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL----QQTLQQEQSVLDQLR 2080
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQE 319
E + EE +EA + E E A+ Q + + + Q A Q +A E
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQV----EEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 320 KLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS-QQMAELSEVLV---LRLE 375
KLR E+ R +A Q + + +E ++F+E + +Q A++ + L L+LE
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 376 NYERQQ----QEVARLQAQVLKLQQ------------RCRMETLPGFQETLAEELRTSLR 419
+ Q+ +E+ RL+A+ + + R +ME L + + E R +
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 420 RMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGL---------MLAAD 470
R + F++ E + +++ ++R AEE L ML
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKEK 2315
Query: 471 IMRGEDFT----PAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
+ ++ T AE Q+EL + +E + A+ ++EET+G++ EA
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAE 2371
Query: 527 RMNVVTSALEASGL 540
R + + EA L
Sbjct: 2372 RQRQLEMSAEAERL 2385
Score = 43.1 bits (100), Expect = 7e-04
Identities = 76/339 (22%), Positives = 145/339 (42%), Gaps = 35/339 (10%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYS 257
L+++R L A ++ ++ + +++ + E ++ + + + + ++++EL QL
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQ 1427
Query: 258 DSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCP--QLE 315
S+ E + + + E E + EEE + EA Q +L+
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIR-----------VVRLQLEATERQRGGAEGELQ 1476
Query: 316 ALQEKLRLLEEENHQLREEASQL-DTLEDEEQ------MLILECVEQFSEAS---QQMAE 365
AL+ + E + Q +EEA +L ++DE Q + + V+ +EA+ Q+ +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 366 LSEVLVLRLENYER--QQQEVARL-QAQV-LKLQQRCRMETLPGFQETLAEELRTSLRRM 421
E L L+ E ER +Q EV R Q QV L+ QR L + + AE+ R +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 422 ISDPVYFMERNYEMPR-----GDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGED 476
+ V + E R + R + +R Q++ EA + A ++ + +
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 477 FTPAEEFVPQEEL--GAAKKVPAEEGVMEEAELVSEETE 513
AE +EE A ++ AEE + + EL +E E
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 44/325 (13%)
Query: 221 LMEENSKLEALLGSAKEEILYLR--------HQVNLRDELLQLYSDSDEEDEDEEEEEEE 272
L E+ ++ E L A++E R H+ ++ + L QL SD E E ++ E+
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 273 KEAEEEQEEEE-----AEEDLQCAHPCDAPKLISQ-----EALLHQHHCPQLEALQEKLR 322
+ Q EEE A + A + + + E L +LEA +++
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 323 LLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEV--LVLRLENYERQ 380
EEE + E +L EE+ A Q+ A L EV L ++E R
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEE-----------AARQRKAALEEVERLKAKVEEARRL 2024
Query: 381 QQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDT 440
++ + A+ L+L Q + L ++ A ++ + + + + + RG+
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK-EQELQQTLQQEQSVLDQLRGEA 2083
Query: 441 SSLR------YDFRYSEDREQV---RGFEAEEGLMLAADIM---RGEDFTPAEEFVPQEE 488
+ R + R +RE R E E L +A+ R + AE+ + E
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143
Query: 489 LGAAKKVPAEEGVMEEAELVSEETE 513
AA++ AE+ + + + E E
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEME 2168
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/298 (25%), Positives = 120/298 (40%), Gaps = 49/298 (16%)
Query: 248 LRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLH 307
L + ++ S++ E+EE E++ AEE + E E L+ Q A H
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR---------QLAEAH 1379
Query: 308 QHHCPQLEALQEKLRLLEEENHQLREEAS-----QLDTLEDEEQMLILECVEQFSEASQQ 362
Q E ++L+ +E REEA+ Q ++++E Q L + E +A +
Sbjct: 1380 AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKAR 1438
Query: 363 MAELSEVLVLRLENYERQQQEVARLQAQVLKLQQ----------RCRMETLPGFQETLAE 412
AE +E LR+E ++ V RLQ + + Q+ R R E Q+ A+
Sbjct: 1439 QAEAAERSRLRIE----EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQ 1493
Query: 413 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM 472
E LRR + D E + + R RE+ R +A E L L A+
Sbjct: 1494 EEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE-- 1546
Query: 473 RGEDFTPAEEFVPQEELGAAKKVPAEEGVME---EAELVSEE---TEGWEEVELELDE 524
AE + Q E+ A++V + EAEL S+ E ++E L E
Sbjct: 1547 ------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Score = 40.0 bits (92), Expect = 0.006
Identities = 72/325 (22%), Positives = 129/325 (39%), Gaps = 58/325 (17%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALL-GSAKEEILYLRHQVNLRDELLQLYS 257
+ ER+ + + V+Q + +E K L G+A++ + EL++L +
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-------AEQELIRLRA 1720
Query: 258 DSDEEDEDEEEEEEE------KEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHC 311
++++ ++ + EEE + A Q+ +E E +L + L++ +A +
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR-AEMEVLLASKARAEEESR 1779
Query: 312 PQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLV 371
E +++L +L EEA++L L +E ++ +Q+AE
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEE------------AKRQRQLAE------ 1821
Query: 372 LRLENYERQQQEVARLQAQVLKL---QQRCRMETLPGFQETLAEELRTSLRRMISDPVYF 428
E+ RQ+ E R+ A+ L R + E +E AE R LRR+ D +
Sbjct: 1822 ---EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1876
Query: 429 MERNYEMP---RGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVP 485
R E + D R + D E E ++GL+ ED V
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLV--------EDTLRQRRQVE 1924
Query: 486 QEELGAAKKVPAEEGVMEEAELVSE 510
+E L A K E+ +AEL E
Sbjct: 1925 EEIL--ALKASFEKAAAGKAELELE 1947
Score = 38.9 bits (89), Expect = 0.013
Identities = 73/361 (20%), Positives = 145/361 (40%), Gaps = 51/361 (14%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E ++ AR ++ +++ + +EE ++ L A E R + EL L + ++
Sbjct: 1430 EAEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATE-----RQRGGAEGELQALRARAE 1483
Query: 261 EEDEDEEEEEEEKEA------EEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQL 314
E + + + +EE E +E Q + +AE +L +A ++ L +L
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543
Query: 315 EALQEKLRLLEEENHQLR-------------------------EEASQLDTLEDEEQMLI 349
+A + + RL + E + R E+ +QL+ EE + +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 350 LECVEQFSEASQQMAELS---EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGF 406
+ E+ +QQ AE E LE ++ + E RL+ Q ++ Q+ +
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA- 1662
Query: 407 QETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLM 466
++ E R + RR ++ +R E+ + R + +E Q R +E +
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR---QLAEGTAQQRLAAEQELIR 1717
Query: 467 LAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
L A+ +GE + + +EEL ++ A + EL +E + E+E+ L
Sbjct: 1718 LRAETEQGEQ----QRQLLEEELARLQR-EAAAATQKRQELEAELAKVRAEMEVLLASKA 1772
Query: 527 R 527
R
Sbjct: 1773 R 1773
Score = 38.9 bits (89), Expect = 0.013
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 16/163 (9%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNL-RDELLQLY 256
LQ+E L V+Q +L E + ++ L S K+ +L + + +L QL+
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 257 SDSDEEDEDEEEEEEEKEAEEEQEEE----EAEEDLQCAHPCDAPKLISQEALLHQHHCP 312
D + + EE++ ++ + EQE + EE + H + QE L
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL------Q 2574
Query: 313 QLE-ALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVE 354
QLE +++ LL EEN +LRE QL LE++ + + E
Sbjct: 2575 QLEQQRRQQEELLAEENQRLRE---QLQLLEEQHRAALAHSEE 2614
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 57.4 bits (137), Expect = 4e-08
Identities = 71/309 (22%), Positives = 130/309 (42%), Gaps = 35/309 (11%)
Query: 237 EEILYLRHQVNLRDE----LLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH 292
EEI H+ L + L+Q ++ + + E E AE E+E+E+ +++ +
Sbjct: 2415 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2474
Query: 293 -PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILE 351
+ + + QE LL + Q L EK LL+ E + +E ++L+ L +E +
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQDEVAKAQQ 2533
Query: 352 CVEQFSEASQQMAELSEVLVLRLENYERQQQE----VARLQAQVLKLQQRCRMETLPGFQ 407
E+ QQM + + LV +E R+Q E V R Q ++ +L+Q+ R + +
Sbjct: 2534 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ-----E 2588
Query: 408 ETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLML 467
E LAEE + + + + +E + R +SE+ A + L
Sbjct: 2589 ELLAEE-----NQRLREQLQLLEEQH----------RAALAHSEE-VTASQVAATKTLPN 2632
Query: 468 AADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATR 527
D + G PA E P+ ++ + + + E L +EE + + +DE R
Sbjct: 2633 GRDALDG----PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2688
Query: 528 MNVVTSALE 536
V L+
Sbjct: 2689 REDVRHYLQ 2697
Score = 45.4 bits (106), Expect = 1e-04
Identities = 66/327 (20%), Positives = 138/327 (42%), Gaps = 36/327 (11%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E DL + + ++K+ ++E ++L+A E L+ Q EL Q +
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-------EAELLQQQ----KELAQEQARRL 2350
Query: 261 EEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEK 320
+ED+++ ++ +E + Q EAE Q +A +L + A + + E Q
Sbjct: 2351 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2410
Query: 321 LRLLEEENHQL-------REEASQLDTLE------DEEQMLILECVEQFSEASQQMAELS 367
+ EE +L +E+ + + TLE D + + E + + +++ + +
Sbjct: 2411 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2470
Query: 368 EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVY 427
++L L+ E + QQE + Q L+ ++L +E E+ + L ++ D V
Sbjct: 2471 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVA 2529
Query: 428 FMERNYEMPRGDTSSL---RYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFV 484
++ E + + R S + + R EAEEG+ + E+ E+
Sbjct: 2530 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR-----RKQEELQQLEQQR 2584
Query: 485 PQEELGAAKKVPAEEGVMEEAELVSEE 511
Q+E A++ + + E+ +L+ E+
Sbjct: 2585 RQQEELLAEE---NQRLREQLQLLEEQ 2608
Score = 44.3 bits (103), Expect = 3e-04
Identities = 63/269 (23%), Positives = 113/269 (42%), Gaps = 22/269 (8%)
Query: 217 QNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAE 276
+ +L + S +A G A+ E+ R + N D L S E+ E E + + AE
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEAARQRQLAAE 1982
Query: 277 EEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENH------- 329
EE+ EAEE +Q + + ++A L + +L+A E+ R L E
Sbjct: 1983 EERRRREAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQL 2040
Query: 330 QLREEASQ--LDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYER--QQQEVA 385
QL +EA+Q L E + + ++ + QQ + + L E R ++ E A
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2100
Query: 386 RLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPR---GDTSS 442
R+QA+ Q R ++E +++ E+ + + + E E R + ++
Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2160
Query: 443 LRYDFRYSEDREQVRGFEAEEGLMLAADI 471
LR + E+ + F AE+ L A +
Sbjct: 2161 LRQKQAADAEMEKHKKF-AEQTLRQKAQV 2188
Score = 44.3 bits (103), Expect = 3e-04
Identities = 84/374 (22%), Positives = 148/374 (39%), Gaps = 46/374 (12%)
Query: 200 RERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDS 259
RER +AR Q + ++ K A KE+ L Q L+ E L
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL----QQTLQQEQSVLDQLR 2084
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQE 319
E + EE +EA + E E A+ Q + + + Q A Q +A E
Sbjct: 2085 GEAEAARRAAEEAEEARVQAEREAAQSRRQV----EEAERLKQSAEEQAQARAQAQAAAE 2140
Query: 320 KLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS-QQMAELSEVLV---LRLE 375
KLR E+ R +A Q + + +E ++F+E + +Q A++ + L L+LE
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2200
Query: 376 NYERQQ----QEVARLQAQVLKLQQ------------RCRMETLPGFQETLAEELRTSLR 419
+ Q+ +E+ RL+A+ + + R +ME L + + E R +
Sbjct: 2201 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2260
Query: 420 RMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGL---------MLAAD 470
R + F++ E + +++ ++R AEE L ML
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKEK 2319
Query: 471 IMRGEDFT----PAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
+ ++ T AE Q+EL + +E + A+ ++EET+G++ EA
Sbjct: 2320 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAE 2375
Query: 527 RMNVVTSALEASGL 540
R + + EA L
Sbjct: 2376 RQRQLEMSAEAERL 2389
Score = 43.1 bits (100), Expect = 7e-04
Identities = 76/339 (22%), Positives = 145/339 (42%), Gaps = 35/339 (10%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYS 257
L+++R L A ++ ++ + +++ + E ++ + + + + ++++EL QL
Sbjct: 1373 LEKQRQLAEAHAQAKAQAEREAKELQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQ 1431
Query: 258 DSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCP--QLE 315
S+ E + + + E E + EEE + EA Q +L+
Sbjct: 1432 SSEAEIQAKARQAEAAERSRLRIEEEIR-----------VVRLQLEATERQRGGAEGELQ 1480
Query: 316 ALQEKLRLLEEENHQLREEASQL-DTLEDEEQ------MLILECVEQFSEAS---QQMAE 365
AL+ + E + Q +EEA +L ++DE Q + + V+ +EA+ Q+ +
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Query: 366 LSEVLVLRLENYER--QQQEVARL-QAQV-LKLQQRCRMETLPGFQETLAEELRTSLRRM 421
E L L+ E ER +Q EV R Q QV L+ QR L + + AE+ R +
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 422 ISDPVYFMERNYEMPR-----GDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGED 476
+ V + E R + R + +R Q++ EA + A ++ + +
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1660
Query: 477 FTPAEEFVPQEEL--GAAKKVPAEEGVMEEAELVSEETE 513
AE +EE A ++ AEE + + EL +E E
Sbjct: 1661 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1699
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 44/325 (13%)
Query: 221 LMEENSKLEALLGSAKEEILYLR--------HQVNLRDELLQLYSDSDEEDEDEEEEEEE 272
L E+ ++ E L A++E R H+ ++ + L QL SD E E ++ E+
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919
Query: 273 KEAEEEQEEEE-----AEEDLQCAHPCDAPKLISQ-----EALLHQHHCPQLEALQEKLR 322
+ Q EEE A + A + + + E L +LEA +++
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979
Query: 323 LLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEV--LVLRLENYERQ 380
EEE + E +L EE+ A Q+ A L EV L ++E R
Sbjct: 1980 AAEEERRRREAEERVQKSLAAEEE-----------AARQRKAALEEVERLKAKVEEARRL 2028
Query: 381 QQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDT 440
++ + A+ L+L Q + L ++ A ++ + + + + + RG+
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK-EQELQQTLQQEQSVLDQLRGEA 2087
Query: 441 SSLR------YDFRYSEDREQV---RGFEAEEGLMLAADIM---RGEDFTPAEEFVPQEE 488
+ R + R +RE R E E L +A+ R + AE+ + E
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2147
Query: 489 LGAAKKVPAEEGVMEEAELVSEETE 513
AA++ AE+ + + + E E
Sbjct: 2148 QEAARRAQAEQAALRQKQAADAEME 2172
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/298 (25%), Positives = 120/298 (40%), Gaps = 49/298 (16%)
Query: 248 LRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLH 307
L + ++ S++ E+EE E++ AEE + E E L+ Q A H
Sbjct: 1333 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR---------QLAEAH 1383
Query: 308 QHHCPQLEALQEKLRLLEEENHQLREEAS-----QLDTLEDEEQMLILECVEQFSEASQQ 362
Q E ++L+ +E REEA+ Q ++++E Q L + E +A +
Sbjct: 1384 AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKAR 1442
Query: 363 MAELSEVLVLRLENYERQQQEVARLQAQVLKLQQ----------RCRMETLPGFQETLAE 412
AE +E LR+E ++ V RLQ + + Q+ R R E Q+ A+
Sbjct: 1443 QAEAAERSRLRIE----EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQ 1497
Query: 413 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM 472
E LRR + D E + + R RE+ R +A E L L A+
Sbjct: 1498 EEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE-- 1550
Query: 473 RGEDFTPAEEFVPQEELGAAKKVPAEEGVME---EAELVSEE---TEGWEEVELELDE 524
AE + Q E+ A++V + EAEL S+ E ++E L E
Sbjct: 1551 ------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1602
Score = 40.0 bits (92), Expect = 0.006
Identities = 72/325 (22%), Positives = 129/325 (39%), Gaps = 58/325 (17%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALL-GSAKEEILYLRHQVNLRDELLQLYS 257
+ ER+ + + V+Q + +E K L G+A++ + EL++L +
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-------AEQELIRLRA 1724
Query: 258 DSDEEDEDEEEEEEE------KEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHC 311
++++ ++ + EEE + A Q+ +E E +L + L++ +A +
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR-AEMEVLLASKARAEEESR 1783
Query: 312 PQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLV 371
E +++L +L EEA++L L +E ++ +Q+AE
Sbjct: 1784 STSEKSKQRLEAEAGRFRELAEEAARLRALAEE------------AKRQRQLAE------ 1825
Query: 372 LRLENYERQQQEVARLQAQVLKL---QQRCRMETLPGFQETLAEELRTSLRRMISDPVYF 428
E+ RQ+ E R+ A+ L R + E +E AE R LRR+ D +
Sbjct: 1826 ---EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1880
Query: 429 MERNYEMP---RGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVP 485
R E + D R + D E E ++GL+ ED V
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLV--------EDTLRQRRQVE 1928
Query: 486 QEELGAAKKVPAEEGVMEEAELVSE 510
+E L A K E+ +AEL E
Sbjct: 1929 EEIL--ALKASFEKAAAGKAELELE 1951
Score = 38.9 bits (89), Expect = 0.013
Identities = 73/361 (20%), Positives = 145/361 (40%), Gaps = 51/361 (14%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E ++ AR ++ +++ + +EE ++ L A E R + EL L + ++
Sbjct: 1434 EAEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATE-----RQRGGAEGELQALRARAE 1487
Query: 261 EEDEDEEEEEEEKEA------EEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQL 314
E + + + +EE E +E Q + +AE +L +A ++ L +L
Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1547
Query: 315 EALQEKLRLLEEENHQLR-------------------------EEASQLDTLEDEEQMLI 349
+A + + RL + E + R E+ +QL+ EE + +
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1607
Query: 350 LECVEQFSEASQQMAELS---EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGF 406
+ E+ +QQ AE E LE ++ + E RL+ Q ++ Q+ +
Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA- 1666
Query: 407 QETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLM 466
++ E R + RR ++ +R E+ + R + +E Q R +E +
Sbjct: 1667 EKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR---QLAEGTAQQRLAAEQELIR 1721
Query: 467 LAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
L A+ +GE + + +EEL ++ A + EL +E + E+E+ L
Sbjct: 1722 LRAETEQGEQ----QRQLLEEELARLQR-EAAAATQKRQELEAELAKVRAEMEVLLASKA 1776
Query: 527 R 527
R
Sbjct: 1777 R 1777
Score = 38.9 bits (89), Expect = 0.013
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 16/163 (9%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNL-RDELLQLY 256
LQ+E L V+Q +L E + ++ L S K+ +L + + +L QL+
Sbjct: 2466 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKDSLLQRERFIEQEKAKLEQLF 2524
Query: 257 SDSDEEDEDEEEEEEEKEAEEEQEEE----EAEEDLQCAHPCDAPKLISQEALLHQHHCP 312
D + + EE++ ++ + EQE + EE + H + QE L
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL------Q 2578
Query: 313 QLE-ALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVE 354
QLE +++ LL EEN +LRE QL LE++ + + E
Sbjct: 2579 QLEQQRRQQEELLAEENQRLRE---QLQLLEEQHRAALAHSEE 2618
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 57.4 bits (137), Expect = 4e-08
Identities = 71/309 (22%), Positives = 130/309 (42%), Gaps = 35/309 (11%)
Query: 237 EEILYLRHQVNLRDE----LLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH 292
EEI H+ L + L+Q ++ + + E E AE E+E+E+ +++ +
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470
Query: 293 -PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILE 351
+ + + QE LL + Q L EK LL+ E + +E ++L+ L +E +
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQDEVAKAQQ 2529
Query: 352 CVEQFSEASQQMAELSEVLVLRLENYERQQQE----VARLQAQVLKLQQRCRMETLPGFQ 407
E+ QQM + + LV +E R+Q E V R Q ++ +L+Q+ R + +
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ-----E 2584
Query: 408 ETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLML 467
E LAEE + + + + +E + R +SE+ A + L
Sbjct: 2585 ELLAEE-----NQRLREQLQLLEEQH----------RAALAHSEE-VTASQVAATKTLPN 2628
Query: 468 AADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATR 527
D + G PA E P+ ++ + + + E L +EE + + +DE R
Sbjct: 2629 GRDALDG----PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2684
Query: 528 MNVVTSALE 536
V L+
Sbjct: 2685 REDVRHYLQ 2693
Score = 45.4 bits (106), Expect = 1e-04
Identities = 66/327 (20%), Positives = 138/327 (42%), Gaps = 36/327 (11%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E DL + + ++K+ ++E ++L+A E L+ Q EL Q +
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-------EAELLQQQ----KELAQEQARRL 2346
Query: 261 EEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEK 320
+ED+++ ++ +E + Q EAE Q +A +L + A + + E Q
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406
Query: 321 LRLLEEENHQL-------REEASQLDTLE------DEEQMLILECVEQFSEASQQMAELS 367
+ EE +L +E+ + + TLE D + + E + + +++ + +
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2466
Query: 368 EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVY 427
++L L+ E + QQE + Q L+ ++L +E E+ + L ++ D V
Sbjct: 2467 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVA 2525
Query: 428 FMERNYEMPRGDTSSL---RYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFV 484
++ E + + R S + + R EAEEG+ + E+ E+
Sbjct: 2526 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR-----RKQEELQQLEQQR 2580
Query: 485 PQEELGAAKKVPAEEGVMEEAELVSEE 511
Q+E A++ + + E+ +L+ E+
Sbjct: 2581 RQQEELLAEE---NQRLREQLQLLEEQ 2604
Score = 44.3 bits (103), Expect = 3e-04
Identities = 63/269 (23%), Positives = 113/269 (42%), Gaps = 22/269 (8%)
Query: 217 QNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAE 276
+ +L + S +A G A+ E+ R + N D L S E+ E E + + AE
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEAARQRQLAAE 1978
Query: 277 EEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENH------- 329
EE+ EAEE +Q + + ++A L + +L+A E+ R L E
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQL 2036
Query: 330 QLREEASQ--LDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYER--QQQEVA 385
QL +EA+Q L E + + ++ + QQ + + L E R ++ E A
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 386 RLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPR---GDTSS 442
R+QA+ Q R ++E +++ E+ + + + E E R + ++
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156
Query: 443 LRYDFRYSEDREQVRGFEAEEGLMLAADI 471
LR + E+ + F AE+ L A +
Sbjct: 2157 LRQKQAADAEMEKHKKF-AEQTLRQKAQV 2184
Score = 44.3 bits (103), Expect = 3e-04
Identities = 84/374 (22%), Positives = 148/374 (39%), Gaps = 46/374 (12%)
Query: 200 RERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDS 259
RER +AR Q + ++ K A KE+ L Q L+ E L
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL----QQTLQQEQSVLDQLR 2080
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQE 319
E + EE +EA + E E A+ Q + + + Q A Q +A E
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQV----EEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 320 KLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS-QQMAELSEVLV---LRLE 375
KLR E+ R +A Q + + +E ++F+E + +Q A++ + L L+LE
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 376 NYERQQ----QEVARLQAQVLKLQQ------------RCRMETLPGFQETLAEELRTSLR 419
+ Q+ +E+ RL+A+ + + R +ME L + + E R +
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 420 RMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGL---------MLAAD 470
R + F++ E + +++ ++R AEE L ML
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKEK 2315
Query: 471 IMRGEDFT----PAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
+ ++ T AE Q+EL + +E + A+ ++EET+G++ EA
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAE 2371
Query: 527 RMNVVTSALEASGL 540
R + + EA L
Sbjct: 2372 RQRQLEMSAEAERL 2385
Score = 43.1 bits (100), Expect = 7e-04
Identities = 76/339 (22%), Positives = 145/339 (42%), Gaps = 35/339 (10%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYS 257
L+++R L A ++ ++ + +++ + E ++ + + + + ++++EL QL
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQ 1427
Query: 258 DSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCP--QLE 315
S+ E + + + E E + EEE + EA Q +L+
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIR-----------VVRLQLEATERQRGGAEGELQ 1476
Query: 316 ALQEKLRLLEEENHQLREEASQL-DTLEDEEQ------MLILECVEQFSEAS---QQMAE 365
AL+ + E + Q +EEA +L ++DE Q + + V+ +EA+ Q+ +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 366 LSEVLVLRLENYER--QQQEVARL-QAQV-LKLQQRCRMETLPGFQETLAEELRTSLRRM 421
E L L+ E ER +Q EV R Q QV L+ QR L + + AE+ R +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 422 ISDPVYFMERNYEMPR-----GDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGED 476
+ V + E R + R + +R Q++ EA + A ++ + +
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 477 FTPAEEFVPQEEL--GAAKKVPAEEGVMEEAELVSEETE 513
AE +EE A ++ AEE + + EL +E E
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 44/325 (13%)
Query: 221 LMEENSKLEALLGSAKEEILYLR--------HQVNLRDELLQLYSDSDEEDEDEEEEEEE 272
L E+ ++ E L A++E R H+ ++ + L QL SD E E ++ E+
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 273 KEAEEEQEEEE-----AEEDLQCAHPCDAPKLISQ-----EALLHQHHCPQLEALQEKLR 322
+ Q EEE A + A + + + E L +LEA +++
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 323 LLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEV--LVLRLENYERQ 380
EEE + E +L EE+ A Q+ A L EV L ++E R
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEE-----------AARQRKAALEEVERLKAKVEEARRL 2024
Query: 381 QQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDT 440
++ + A+ L+L Q + L ++ A ++ + + + + + RG+
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK-EQELQQTLQQEQSVLDQLRGEA 2083
Query: 441 SSLR------YDFRYSEDREQV---RGFEAEEGLMLAADIM---RGEDFTPAEEFVPQEE 488
+ R + R +RE R E E L +A+ R + AE+ + E
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143
Query: 489 LGAAKKVPAEEGVMEEAELVSEETE 513
AA++ AE+ + + + E E
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEME 2168
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/298 (25%), Positives = 120/298 (40%), Gaps = 49/298 (16%)
Query: 248 LRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLH 307
L + ++ S++ E+EE E++ AEE + E E L+ Q A H
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR---------QLAEAH 1379
Query: 308 QHHCPQLEALQEKLRLLEEENHQLREEAS-----QLDTLEDEEQMLILECVEQFSEASQQ 362
Q E ++L+ +E REEA+ Q ++++E Q L + E +A +
Sbjct: 1380 AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKAR 1438
Query: 363 MAELSEVLVLRLENYERQQQEVARLQAQVLKLQQ----------RCRMETLPGFQETLAE 412
AE +E LR+E ++ V RLQ + + Q+ R R E Q+ A+
Sbjct: 1439 QAEAAERSRLRIE----EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQ 1493
Query: 413 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM 472
E LRR + D E + + R RE+ R +A E L L A+
Sbjct: 1494 EEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE-- 1546
Query: 473 RGEDFTPAEEFVPQEELGAAKKVPAEEGVME---EAELVSEE---TEGWEEVELELDE 524
AE + Q E+ A++V + EAEL S+ E ++E L E
Sbjct: 1547 ------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Score = 40.0 bits (92), Expect = 0.006
Identities = 72/325 (22%), Positives = 129/325 (39%), Gaps = 58/325 (17%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALL-GSAKEEILYLRHQVNLRDELLQLYS 257
+ ER+ + + V+Q + +E K L G+A++ + EL++L +
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-------AEQELIRLRA 1720
Query: 258 DSDEEDEDEEEEEEE------KEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHC 311
++++ ++ + EEE + A Q+ +E E +L + L++ +A +
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR-AEMEVLLASKARAEEESR 1779
Query: 312 PQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLV 371
E +++L +L EEA++L L +E ++ +Q+AE
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEE------------AKRQRQLAE------ 1821
Query: 372 LRLENYERQQQEVARLQAQVLKL---QQRCRMETLPGFQETLAEELRTSLRRMISDPVYF 428
E+ RQ+ E R+ A+ L R + E +E AE R LRR+ D +
Sbjct: 1822 ---EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1876
Query: 429 MERNYEMP---RGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVP 485
R E + D R + D E E ++GL+ ED V
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLV--------EDTLRQRRQVE 1924
Query: 486 QEELGAAKKVPAEEGVMEEAELVSE 510
+E L A K E+ +AEL E
Sbjct: 1925 EEIL--ALKASFEKAAAGKAELELE 1947
Score = 38.9 bits (89), Expect = 0.013
Identities = 73/361 (20%), Positives = 145/361 (40%), Gaps = 51/361 (14%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E ++ AR ++ +++ + +EE ++ L A E R + EL L + ++
Sbjct: 1430 EAEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATE-----RQRGGAEGELQALRARAE 1483
Query: 261 EEDEDEEEEEEEKEA------EEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQL 314
E + + + +EE E +E Q + +AE +L +A ++ L +L
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543
Query: 315 EALQEKLRLLEEENHQLR-------------------------EEASQLDTLEDEEQMLI 349
+A + + RL + E + R E+ +QL+ EE + +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 350 LECVEQFSEASQQMAELS---EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGF 406
+ E+ +QQ AE E LE ++ + E RL+ Q ++ Q+ +
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA- 1662
Query: 407 QETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLM 466
++ E R + RR ++ +R E+ + R + +E Q R +E +
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR---QLAEGTAQQRLAAEQELIR 1717
Query: 467 LAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
L A+ +GE + + +EEL ++ A + EL +E + E+E+ L
Sbjct: 1718 LRAETEQGEQ----QRQLLEEELARLQR-EAAAATQKRQELEAELAKVRAEMEVLLASKA 1772
Query: 527 R 527
R
Sbjct: 1773 R 1773
Score = 38.9 bits (89), Expect = 0.013
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 16/163 (9%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNL-RDELLQLY 256
LQ+E L V+Q +L E + ++ L S K+ +L + + +L QL+
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 257 SDSDEEDEDEEEEEEEKEAEEEQEEE----EAEEDLQCAHPCDAPKLISQEALLHQHHCP 312
D + + EE++ ++ + EQE + EE + H + QE L
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL------Q 2574
Query: 313 QLE-ALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVE 354
QLE +++ LL EEN +LRE QL LE++ + + E
Sbjct: 2575 QLEQQRRQQEELLAEENQRLRE---QLQLLEEQHRAALAHSEE 2614
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 57.4 bits (137), Expect = 4e-08
Identities = 71/309 (22%), Positives = 130/309 (42%), Gaps = 35/309 (11%)
Query: 237 EEILYLRHQVNLRDE----LLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH 292
EEI H+ L + L+Q ++ + + E E AE E+E+E+ +++ +
Sbjct: 2379 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2438
Query: 293 -PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILE 351
+ + + QE LL + Q L EK LL+ E + +E ++L+ L +E +
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQDEVAKAQQ 2497
Query: 352 CVEQFSEASQQMAELSEVLVLRLENYERQQQE----VARLQAQVLKLQQRCRMETLPGFQ 407
E+ QQM + + LV +E R+Q E V R Q ++ +L+Q+ R + +
Sbjct: 2498 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ-----E 2552
Query: 408 ETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLML 467
E LAEE + + + + +E + R +SE+ A + L
Sbjct: 2553 ELLAEE-----NQRLREQLQLLEEQH----------RAALAHSEE-VTASQVAATKTLPN 2596
Query: 468 AADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATR 527
D + G PA E P+ ++ + + + E L +EE + + +DE R
Sbjct: 2597 GRDALDG----PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2652
Query: 528 MNVVTSALE 536
V L+
Sbjct: 2653 REDVRHYLQ 2661
Score = 45.4 bits (106), Expect = 1e-04
Identities = 66/327 (20%), Positives = 138/327 (42%), Gaps = 36/327 (11%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E DL + + ++K+ ++E ++L+A E L+ Q EL Q +
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-------EAELLQQQ----KELAQEQARRL 2314
Query: 261 EEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEK 320
+ED+++ ++ +E + Q EAE Q +A +L + A + + E Q
Sbjct: 2315 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2374
Query: 321 LRLLEEENHQL-------REEASQLDTLE------DEEQMLILECVEQFSEASQQMAELS 367
+ EE +L +E+ + + TLE D + + E + + +++ + +
Sbjct: 2375 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2434
Query: 368 EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVY 427
++L L+ E + QQE + Q L+ ++L +E E+ + L ++ D V
Sbjct: 2435 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVA 2493
Query: 428 FMERNYEMPRGDTSSL---RYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFV 484
++ E + + R S + + R EAEEG+ + E+ E+
Sbjct: 2494 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR-----RKQEELQQLEQQR 2548
Query: 485 PQEELGAAKKVPAEEGVMEEAELVSEE 511
Q+E A++ + + E+ +L+ E+
Sbjct: 2549 RQQEELLAEE---NQRLREQLQLLEEQ 2572
Score = 44.3 bits (103), Expect = 3e-04
Identities = 63/269 (23%), Positives = 113/269 (42%), Gaps = 22/269 (8%)
Query: 217 QNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAE 276
+ +L + S +A G A+ E+ R + N D L S E+ E E + + AE
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEAARQRQLAAE 1946
Query: 277 EEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENH------- 329
EE+ EAEE +Q + + ++A L + +L+A E+ R L E
Sbjct: 1947 EERRRREAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQL 2004
Query: 330 QLREEASQ--LDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYER--QQQEVA 385
QL +EA+Q L E + + ++ + QQ + + L E R ++ E A
Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2064
Query: 386 RLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPR---GDTSS 442
R+QA+ Q R ++E +++ E+ + + + E E R + ++
Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2124
Query: 443 LRYDFRYSEDREQVRGFEAEEGLMLAADI 471
LR + E+ + F AE+ L A +
Sbjct: 2125 LRQKQAADAEMEKHKKF-AEQTLRQKAQV 2152
Score = 44.3 bits (103), Expect = 3e-04
Identities = 84/374 (22%), Positives = 148/374 (39%), Gaps = 46/374 (12%)
Query: 200 RERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDS 259
RER +AR Q + ++ K A KE+ L Q L+ E L
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL----QQTLQQEQSVLDQLR 2048
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQE 319
E + EE +EA + E E A+ Q + + + Q A Q +A E
Sbjct: 2049 GEAEAARRAAEEAEEARVQAEREAAQSRRQV----EEAERLKQSAEEQAQARAQAQAAAE 2104
Query: 320 KLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS-QQMAELSEVLV---LRLE 375
KLR E+ R +A Q + + +E ++F+E + +Q A++ + L L+LE
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2164
Query: 376 NYERQQ----QEVARLQAQVLKLQQ------------RCRMETLPGFQETLAEELRTSLR 419
+ Q+ +E+ RL+A+ + + R +ME L + + E R +
Sbjct: 2165 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2224
Query: 420 RMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGL---------MLAAD 470
R + F++ E + +++ ++R AEE L ML
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKEK 2283
Query: 471 IMRGEDFT----PAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
+ ++ T AE Q+EL + +E + A+ ++EET+G++ EA
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAE 2339
Query: 527 RMNVVTSALEASGL 540
R + + EA L
Sbjct: 2340 RQRQLEMSAEAERL 2353
Score = 43.1 bits (100), Expect = 7e-04
Identities = 76/339 (22%), Positives = 145/339 (42%), Gaps = 35/339 (10%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYS 257
L+++R L A ++ ++ + +++ + E ++ + + + + ++++EL QL
Sbjct: 1337 LEKQRQLAEAHAQAKAQAEREAKELQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQ 1395
Query: 258 DSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCP--QLE 315
S+ E + + + E E + EEE + EA Q +L+
Sbjct: 1396 SSEAEIQAKARQAEAAERSRLRIEEEIR-----------VVRLQLEATERQRGGAEGELQ 1444
Query: 316 ALQEKLRLLEEENHQLREEASQL-DTLEDEEQ------MLILECVEQFSEAS---QQMAE 365
AL+ + E + Q +EEA +L ++DE Q + + V+ +EA+ Q+ +
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504
Query: 366 LSEVLVLRLENYER--QQQEVARL-QAQV-LKLQQRCRMETLPGFQETLAEELRTSLRRM 421
E L L+ E ER +Q EV R Q QV L+ QR L + + AE+ R +
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 422 ISDPVYFMERNYEMPR-----GDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGED 476
+ V + E R + R + +R Q++ EA + A ++ + +
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1624
Query: 477 FTPAEEFVPQEEL--GAAKKVPAEEGVMEEAELVSEETE 513
AE +EE A ++ AEE + + EL +E E
Sbjct: 1625 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1663
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 44/325 (13%)
Query: 221 LMEENSKLEALLGSAKEEILYLR--------HQVNLRDELLQLYSDSDEEDEDEEEEEEE 272
L E+ ++ E L A++E R H+ ++ + L QL SD E E ++ E+
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1883
Query: 273 KEAEEEQEEEE-----AEEDLQCAHPCDAPKLISQ-----EALLHQHHCPQLEALQEKLR 322
+ Q EEE A + A + + + E L +LEA +++
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943
Query: 323 LLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEV--LVLRLENYERQ 380
EEE + E +L EE+ A Q+ A L EV L ++E R
Sbjct: 1944 AAEEERRRREAEERVQKSLAAEEE-----------AARQRKAALEEVERLKAKVEEARRL 1992
Query: 381 QQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDT 440
++ + A+ L+L Q + L ++ A ++ + + + + + RG+
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK-EQELQQTLQQEQSVLDQLRGEA 2051
Query: 441 SSLR------YDFRYSEDREQV---RGFEAEEGLMLAADIM---RGEDFTPAEEFVPQEE 488
+ R + R +RE R E E L +A+ R + AE+ + E
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2111
Query: 489 LGAAKKVPAEEGVMEEAELVSEETE 513
AA++ AE+ + + + E E
Sbjct: 2112 QEAARRAQAEQAALRQKQAADAEME 2136
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/298 (25%), Positives = 120/298 (40%), Gaps = 49/298 (16%)
Query: 248 LRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLH 307
L + ++ S++ E+EE E++ AEE + E E L+ Q A H
Sbjct: 1297 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR---------QLAEAH 1347
Query: 308 QHHCPQLEALQEKLRLLEEENHQLREEAS-----QLDTLEDEEQMLILECVEQFSEASQQ 362
Q E ++L+ +E REEA+ Q ++++E Q L + E +A +
Sbjct: 1348 AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKAR 1406
Query: 363 MAELSEVLVLRLENYERQQQEVARLQAQVLKLQQ----------RCRMETLPGFQETLAE 412
AE +E LR+E ++ V RLQ + + Q+ R R E Q+ A+
Sbjct: 1407 QAEAAERSRLRIE----EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQ 1461
Query: 413 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM 472
E LRR + D E + + R RE+ R +A E L L A+
Sbjct: 1462 EEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE-- 1514
Query: 473 RGEDFTPAEEFVPQEELGAAKKVPAEEGVME---EAELVSEE---TEGWEEVELELDE 524
AE + Q E+ A++V + EAEL S+ E ++E L E
Sbjct: 1515 ------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1566
Score = 40.0 bits (92), Expect = 0.006
Identities = 72/325 (22%), Positives = 129/325 (39%), Gaps = 58/325 (17%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALL-GSAKEEILYLRHQVNLRDELLQLYS 257
+ ER+ + + V+Q + +E K L G+A++ + EL++L +
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-------AEQELIRLRA 1688
Query: 258 DSDEEDEDEEEEEEE------KEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHC 311
++++ ++ + EEE + A Q+ +E E +L + L++ +A +
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR-AEMEVLLASKARAEEESR 1747
Query: 312 PQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLV 371
E +++L +L EEA++L L +E ++ +Q+AE
Sbjct: 1748 STSEKSKQRLEAEAGRFRELAEEAARLRALAEE------------AKRQRQLAE------ 1789
Query: 372 LRLENYERQQQEVARLQAQVLKL---QQRCRMETLPGFQETLAEELRTSLRRMISDPVYF 428
E+ RQ+ E R+ A+ L R + E +E AE R LRR+ D +
Sbjct: 1790 ---EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1844
Query: 429 MERNYEMP---RGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVP 485
R E + D R + D E E ++GL+ ED V
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLV--------EDTLRQRRQVE 1892
Query: 486 QEELGAAKKVPAEEGVMEEAELVSE 510
+E L A K E+ +AEL E
Sbjct: 1893 EEIL--ALKASFEKAAAGKAELELE 1915
Score = 38.9 bits (89), Expect = 0.013
Identities = 73/361 (20%), Positives = 145/361 (40%), Gaps = 51/361 (14%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E ++ AR ++ +++ + +EE ++ L A E R + EL L + ++
Sbjct: 1398 EAEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATE-----RQRGGAEGELQALRARAE 1451
Query: 261 EEDEDEEEEEEEKEA------EEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQL 314
E + + + +EE E +E Q + +AE +L +A ++ L +L
Sbjct: 1452 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1511
Query: 315 EALQEKLRLLEEENHQLR-------------------------EEASQLDTLEDEEQMLI 349
+A + + RL + E + R E+ +QL+ EE + +
Sbjct: 1512 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1571
Query: 350 LECVEQFSEASQQMAELS---EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGF 406
+ E+ +QQ AE E LE ++ + E RL+ Q ++ Q+ +
Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA- 1630
Query: 407 QETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLM 466
++ E R + RR ++ +R E+ + R + +E Q R +E +
Sbjct: 1631 EKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR---QLAEGTAQQRLAAEQELIR 1685
Query: 467 LAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
L A+ +GE + + +EEL ++ A + EL +E + E+E+ L
Sbjct: 1686 LRAETEQGEQ----QRQLLEEELARLQR-EAAAATQKRQELEAELAKVRAEMEVLLASKA 1740
Query: 527 R 527
R
Sbjct: 1741 R 1741
Score = 38.9 bits (89), Expect = 0.013
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 16/163 (9%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNL-RDELLQLY 256
LQ+E L V+Q +L E + ++ L S K+ +L + + +L QL+
Sbjct: 2430 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKDSLLQRERFIEQEKAKLEQLF 2488
Query: 257 SDSDEEDEDEEEEEEEKEAEEEQEEE----EAEEDLQCAHPCDAPKLISQEALLHQHHCP 312
D + + EE++ ++ + EQE + EE + H + QE L
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL------Q 2542
Query: 313 QLE-ALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVE 354
QLE +++ LL EEN +LRE QL LE++ + + E
Sbjct: 2543 QLEQQRRQQEELLAEENQRLRE---QLQLLEEQHRAALAHSEE 2582
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 57.4 bits (137), Expect = 4e-08
Identities = 71/309 (22%), Positives = 130/309 (42%), Gaps = 35/309 (11%)
Query: 237 EEILYLRHQVNLRDE----LLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH 292
EEI H+ L + L+Q ++ + + E E AE E+E+E+ +++ +
Sbjct: 2548 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2607
Query: 293 -PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILE 351
+ + + QE LL + Q L EK LL+ E + +E ++L+ L +E +
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQDEVAKAQQ 2666
Query: 352 CVEQFSEASQQMAELSEVLVLRLENYERQQQE----VARLQAQVLKLQQRCRMETLPGFQ 407
E+ QQM + + LV +E R+Q E V R Q ++ +L+Q+ R + +
Sbjct: 2667 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ-----E 2721
Query: 408 ETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLML 467
E LAEE + + + + +E + R +SE+ A + L
Sbjct: 2722 ELLAEE-----NQRLREQLQLLEEQH----------RAALAHSEE-VTASQVAATKTLPN 2765
Query: 468 AADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATR 527
D + G PA E P+ ++ + + + E L +EE + + +DE R
Sbjct: 2766 GRDALDG----PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2821
Query: 528 MNVVTSALE 536
V L+
Sbjct: 2822 REDVRHYLQ 2830
Score = 45.4 bits (106), Expect = 1e-04
Identities = 66/327 (20%), Positives = 138/327 (42%), Gaps = 36/327 (11%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E DL + + ++K+ ++E ++L+A E L+ Q EL Q +
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-------EAELLQQQ----KELAQEQARRL 2483
Query: 261 EEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEK 320
+ED+++ ++ +E + Q EAE Q +A +L + A + + E Q
Sbjct: 2484 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2543
Query: 321 LRLLEEENHQL-------REEASQLDTLE------DEEQMLILECVEQFSEASQQMAELS 367
+ EE +L +E+ + + TLE D + + E + + +++ + +
Sbjct: 2544 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2603
Query: 368 EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVY 427
++L L+ E + QQE + Q L+ ++L +E E+ + L ++ D V
Sbjct: 2604 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVA 2662
Query: 428 FMERNYEMPRGDTSSL---RYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFV 484
++ E + + R S + + R EAEEG+ + E+ E+
Sbjct: 2663 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR-----RKQEELQQLEQQR 2717
Query: 485 PQEELGAAKKVPAEEGVMEEAELVSEE 511
Q+E A++ + + E+ +L+ E+
Sbjct: 2718 RQQEELLAEE---NQRLREQLQLLEEQ 2741
Score = 44.3 bits (103), Expect = 3e-04
Identities = 63/269 (23%), Positives = 113/269 (42%), Gaps = 22/269 (8%)
Query: 217 QNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAE 276
+ +L + S +A G A+ E+ R + N D L S E+ E E + + AE
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEAARQRQLAAE 2115
Query: 277 EEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENH------- 329
EE+ EAEE +Q + + ++A L + +L+A E+ R L E
Sbjct: 2116 EERRRREAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQL 2173
Query: 330 QLREEASQ--LDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYER--QQQEVA 385
QL +EA+Q L E + + ++ + QQ + + L E R ++ E A
Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2233
Query: 386 RLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPR---GDTSS 442
R+QA+ Q R ++E +++ E+ + + + E E R + ++
Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2293
Query: 443 LRYDFRYSEDREQVRGFEAEEGLMLAADI 471
LR + E+ + F AE+ L A +
Sbjct: 2294 LRQKQAADAEMEKHKKF-AEQTLRQKAQV 2321
Score = 44.3 bits (103), Expect = 3e-04
Identities = 84/374 (22%), Positives = 148/374 (39%), Gaps = 46/374 (12%)
Query: 200 RERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDS 259
RER +AR Q + ++ K A KE+ L Q L+ E L
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL----QQTLQQEQSVLDQLR 2217
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQE 319
E + EE +EA + E E A+ Q + + + Q A Q +A E
Sbjct: 2218 GEAEAARRAAEEAEEARVQAEREAAQSRRQV----EEAERLKQSAEEQAQARAQAQAAAE 2273
Query: 320 KLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS-QQMAELSEVLV---LRLE 375
KLR E+ R +A Q + + +E ++F+E + +Q A++ + L L+LE
Sbjct: 2274 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2333
Query: 376 NYERQQ----QEVARLQAQVLKLQQ------------RCRMETLPGFQETLAEELRTSLR 419
+ Q+ +E+ RL+A+ + + R +ME L + + E R +
Sbjct: 2334 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2393
Query: 420 RMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGL---------MLAAD 470
R + F++ E + +++ ++R AEE L ML
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKEK 2452
Query: 471 IMRGEDFT----PAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
+ ++ T AE Q+EL + +E + A+ ++EET+G++ EA
Sbjct: 2453 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAE 2508
Query: 527 RMNVVTSALEASGL 540
R + + EA L
Sbjct: 2509 RQRQLEMSAEAERL 2522
Score = 43.1 bits (100), Expect = 7e-04
Identities = 76/339 (22%), Positives = 145/339 (42%), Gaps = 35/339 (10%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYS 257
L+++R L A ++ ++ + +++ + E ++ + + + + ++++EL QL
Sbjct: 1506 LEKQRQLAEAHAQAKAQAEREAKELQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQ 1564
Query: 258 DSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCP--QLE 315
S+ E + + + E E + EEE + EA Q +L+
Sbjct: 1565 SSEAEIQAKARQAEAAERSRLRIEEEIR-----------VVRLQLEATERQRGGAEGELQ 1613
Query: 316 ALQEKLRLLEEENHQLREEASQL-DTLEDEEQ------MLILECVEQFSEAS---QQMAE 365
AL+ + E + Q +EEA +L ++DE Q + + V+ +EA+ Q+ +
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673
Query: 366 LSEVLVLRLENYER--QQQEVARL-QAQV-LKLQQRCRMETLPGFQETLAEELRTSLRRM 421
E L L+ E ER +Q EV R Q QV L+ QR L + + AE+ R +
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 422 ISDPVYFMERNYEMPR-----GDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGED 476
+ V + E R + R + +R Q++ EA + A ++ + +
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1793
Query: 477 FTPAEEFVPQEEL--GAAKKVPAEEGVMEEAELVSEETE 513
AE +EE A ++ AEE + + EL +E E
Sbjct: 1794 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1832
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 44/325 (13%)
Query: 221 LMEENSKLEALLGSAKEEILYLR--------HQVNLRDELLQLYSDSDEEDEDEEEEEEE 272
L E+ ++ E L A++E R H+ ++ + L QL SD E E ++ E+
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 2052
Query: 273 KEAEEEQEEEE-----AEEDLQCAHPCDAPKLISQ-----EALLHQHHCPQLEALQEKLR 322
+ Q EEE A + A + + + E L +LEA +++
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112
Query: 323 LLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEV--LVLRLENYERQ 380
EEE + E +L EE+ A Q+ A L EV L ++E R
Sbjct: 2113 AAEEERRRREAEERVQKSLAAEEE-----------AARQRKAALEEVERLKAKVEEARRL 2161
Query: 381 QQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDT 440
++ + A+ L+L Q + L ++ A ++ + + + + + RG+
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK-EQELQQTLQQEQSVLDQLRGEA 2220
Query: 441 SSLR------YDFRYSEDREQV---RGFEAEEGLMLAADIM---RGEDFTPAEEFVPQEE 488
+ R + R +RE R E E L +A+ R + AE+ + E
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280
Query: 489 LGAAKKVPAEEGVMEEAELVSEETE 513
AA++ AE+ + + + E E
Sbjct: 2281 QEAARRAQAEQAALRQKQAADAEME 2305
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/298 (25%), Positives = 120/298 (40%), Gaps = 49/298 (16%)
Query: 248 LRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLH 307
L + ++ S++ E+EE E++ AEE + E E L+ Q A H
Sbjct: 1466 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR---------QLAEAH 1516
Query: 308 QHHCPQLEALQEKLRLLEEENHQLREEAS-----QLDTLEDEEQMLILECVEQFSEASQQ 362
Q E ++L+ +E REEA+ Q ++++E Q L + E +A +
Sbjct: 1517 AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKAR 1575
Query: 363 MAELSEVLVLRLENYERQQQEVARLQAQVLKLQQ----------RCRMETLPGFQETLAE 412
AE +E LR+E ++ V RLQ + + Q+ R R E Q+ A+
Sbjct: 1576 QAEAAERSRLRIE----EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQ 1630
Query: 413 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM 472
E LRR + D E + + R RE+ R +A E L L A+
Sbjct: 1631 EEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE-- 1683
Query: 473 RGEDFTPAEEFVPQEELGAAKKVPAEEGVME---EAELVSEE---TEGWEEVELELDE 524
AE + Q E+ A++V + EAEL S+ E ++E L E
Sbjct: 1684 ------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735
Score = 40.0 bits (92), Expect = 0.006
Identities = 72/325 (22%), Positives = 129/325 (39%), Gaps = 58/325 (17%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALL-GSAKEEILYLRHQVNLRDELLQLYS 257
+ ER+ + + V+Q + +E K L G+A++ + EL++L +
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-------AEQELIRLRA 1857
Query: 258 DSDEEDEDEEEEEEE------KEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHC 311
++++ ++ + EEE + A Q+ +E E +L + L++ +A +
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR-AEMEVLLASKARAEEESR 1916
Query: 312 PQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLV 371
E +++L +L EEA++L L +E ++ +Q+AE
Sbjct: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRALAEE------------AKRQRQLAE------ 1958
Query: 372 LRLENYERQQQEVARLQAQVLKL---QQRCRMETLPGFQETLAEELRTSLRRMISDPVYF 428
E+ RQ+ E R+ A+ L R + E +E AE R LRR+ D +
Sbjct: 1959 ---EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 2013
Query: 429 MERNYEMP---RGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVP 485
R E + D R + D E E ++GL+ ED V
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLV--------EDTLRQRRQVE 2061
Query: 486 QEELGAAKKVPAEEGVMEEAELVSE 510
+E L A K E+ +AEL E
Sbjct: 2062 EEIL--ALKASFEKAAAGKAELELE 2084
Score = 38.9 bits (89), Expect = 0.013
Identities = 73/361 (20%), Positives = 145/361 (40%), Gaps = 51/361 (14%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E ++ AR ++ +++ + +EE ++ L A E R + EL L + ++
Sbjct: 1567 EAEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATE-----RQRGGAEGELQALRARAE 1620
Query: 261 EEDEDEEEEEEEKEA------EEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQL 314
E + + + +EE E +E Q + +AE +L +A ++ L +L
Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680
Query: 315 EALQEKLRLLEEENHQLR-------------------------EEASQLDTLEDEEQMLI 349
+A + + RL + E + R E+ +QL+ EE + +
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740
Query: 350 LECVEQFSEASQQMAELS---EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGF 406
+ E+ +QQ AE E LE ++ + E RL+ Q ++ Q+ +
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA- 1799
Query: 407 QETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLM 466
++ E R + RR ++ +R E+ + R + +E Q R +E +
Sbjct: 1800 EKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR---QLAEGTAQQRLAAEQELIR 1854
Query: 467 LAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
L A+ +GE + + +EEL ++ A + EL +E + E+E+ L
Sbjct: 1855 LRAETEQGEQ----QRQLLEEELARLQR-EAAAATQKRQELEAELAKVRAEMEVLLASKA 1909
Query: 527 R 527
R
Sbjct: 1910 R 1910
Score = 38.9 bits (89), Expect = 0.013
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 16/163 (9%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNL-RDELLQLY 256
LQ+E L V+Q +L E + ++ L S K+ +L + + +L QL+
Sbjct: 2599 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKDSLLQRERFIEQEKAKLEQLF 2657
Query: 257 SDSDEEDEDEEEEEEEKEAEEEQEEE----EAEEDLQCAHPCDAPKLISQEALLHQHHCP 312
D + + EE++ ++ + EQE + EE + H + QE L
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL------Q 2711
Query: 313 QLE-ALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVE 354
QLE +++ LL EEN +LRE QL LE++ + + E
Sbjct: 2712 QLEQQRRQQEELLAEENQRLRE---QLQLLEEQHRAALAHSEE 2751
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 57.4 bits (137), Expect = 4e-08
Identities = 71/309 (22%), Positives = 130/309 (42%), Gaps = 35/309 (11%)
Query: 237 EEILYLRHQVNLRDE----LLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH 292
EEI H+ L + L+Q ++ + + E E AE E+E+E+ +++ +
Sbjct: 2389 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2448
Query: 293 -PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILE 351
+ + + QE LL + Q L EK LL+ E + +E ++L+ L +E +
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQDEVAKAQQ 2507
Query: 352 CVEQFSEASQQMAELSEVLVLRLENYERQQQE----VARLQAQVLKLQQRCRMETLPGFQ 407
E+ QQM + + LV +E R+Q E V R Q ++ +L+Q+ R + +
Sbjct: 2508 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ-----E 2562
Query: 408 ETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLML 467
E LAEE + + + + +E + R +SE+ A + L
Sbjct: 2563 ELLAEE-----NQRLREQLQLLEEQH----------RAALAHSEE-VTASQVAATKTLPN 2606
Query: 468 AADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATR 527
D + G PA E P+ ++ + + + E L +EE + + +DE R
Sbjct: 2607 GRDALDG----PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2662
Query: 528 MNVVTSALE 536
V L+
Sbjct: 2663 REDVRHYLQ 2671
Score = 45.4 bits (106), Expect = 1e-04
Identities = 66/327 (20%), Positives = 138/327 (42%), Gaps = 36/327 (11%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E DL + + ++K+ ++E ++L+A E L+ Q EL Q +
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-------EAELLQQQ----KELAQEQARRL 2324
Query: 261 EEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEK 320
+ED+++ ++ +E + Q EAE Q +A +L + A + + E Q
Sbjct: 2325 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2384
Query: 321 LRLLEEENHQL-------REEASQLDTLE------DEEQMLILECVEQFSEASQQMAELS 367
+ EE +L +E+ + + TLE D + + E + + +++ + +
Sbjct: 2385 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2444
Query: 368 EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVY 427
++L L+ E + QQE + Q L+ ++L +E E+ + L ++ D V
Sbjct: 2445 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVA 2503
Query: 428 FMERNYEMPRGDTSSL---RYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFV 484
++ E + + R S + + R EAEEG+ + E+ E+
Sbjct: 2504 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR-----RKQEELQQLEQQR 2558
Query: 485 PQEELGAAKKVPAEEGVMEEAELVSEE 511
Q+E A++ + + E+ +L+ E+
Sbjct: 2559 RQQEELLAEE---NQRLREQLQLLEEQ 2582
Score = 44.3 bits (103), Expect = 3e-04
Identities = 63/269 (23%), Positives = 113/269 (42%), Gaps = 22/269 (8%)
Query: 217 QNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAE 276
+ +L + S +A G A+ E+ R + N D L S E+ E E + + AE
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEAARQRQLAAE 1956
Query: 277 EEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENH------- 329
EE+ EAEE +Q + + ++A L + +L+A E+ R L E
Sbjct: 1957 EERRRREAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQL 2014
Query: 330 QLREEASQ--LDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYER--QQQEVA 385
QL +EA+Q L E + + ++ + QQ + + L E R ++ E A
Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2074
Query: 386 RLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPR---GDTSS 442
R+QA+ Q R ++E +++ E+ + + + E E R + ++
Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2134
Query: 443 LRYDFRYSEDREQVRGFEAEEGLMLAADI 471
LR + E+ + F AE+ L A +
Sbjct: 2135 LRQKQAADAEMEKHKKF-AEQTLRQKAQV 2162
Score = 44.3 bits (103), Expect = 3e-04
Identities = 84/374 (22%), Positives = 148/374 (39%), Gaps = 46/374 (12%)
Query: 200 RERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDS 259
RER +AR Q + ++ K A KE+ L Q L+ E L
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL----QQTLQQEQSVLDQLR 2058
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQE 319
E + EE +EA + E E A+ Q + + + Q A Q +A E
Sbjct: 2059 GEAEAARRAAEEAEEARVQAEREAAQSRRQV----EEAERLKQSAEEQAQARAQAQAAAE 2114
Query: 320 KLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS-QQMAELSEVLV---LRLE 375
KLR E+ R +A Q + + +E ++F+E + +Q A++ + L L+LE
Sbjct: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174
Query: 376 NYERQQ----QEVARLQAQVLKLQQ------------RCRMETLPGFQETLAEELRTSLR 419
+ Q+ +E+ RL+A+ + + R +ME L + + E R +
Sbjct: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234
Query: 420 RMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGL---------MLAAD 470
R + F++ E + +++ ++R AEE L ML
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKEK 2293
Query: 471 IMRGEDFT----PAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
+ ++ T AE Q+EL + +E + A+ ++EET+G++ EA
Sbjct: 2294 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAE 2349
Query: 527 RMNVVTSALEASGL 540
R + + EA L
Sbjct: 2350 RQRQLEMSAEAERL 2363
Score = 43.1 bits (100), Expect = 7e-04
Identities = 76/339 (22%), Positives = 145/339 (42%), Gaps = 35/339 (10%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYS 257
L+++R L A ++ ++ + +++ + E ++ + + + + ++++EL QL
Sbjct: 1347 LEKQRQLAEAHAQAKAQAEREAKELQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQ 1405
Query: 258 DSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCP--QLE 315
S+ E + + + E E + EEE + EA Q +L+
Sbjct: 1406 SSEAEIQAKARQAEAAERSRLRIEEEIR-----------VVRLQLEATERQRGGAEGELQ 1454
Query: 316 ALQEKLRLLEEENHQLREEASQL-DTLEDEEQ------MLILECVEQFSEAS---QQMAE 365
AL+ + E + Q +EEA +L ++DE Q + + V+ +EA+ Q+ +
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
Query: 366 LSEVLVLRLENYER--QQQEVARL-QAQV-LKLQQRCRMETLPGFQETLAEELRTSLRRM 421
E L L+ E ER +Q EV R Q QV L+ QR L + + AE+ R +
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Query: 422 ISDPVYFMERNYEMPR-----GDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGED 476
+ V + E R + R + +R Q++ EA + A ++ + +
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1634
Query: 477 FTPAEEFVPQEEL--GAAKKVPAEEGVMEEAELVSEETE 513
AE +EE A ++ AEE + + EL +E E
Sbjct: 1635 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1673
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 44/325 (13%)
Query: 221 LMEENSKLEALLGSAKEEILYLR--------HQVNLRDELLQLYSDSDEEDEDEEEEEEE 272
L E+ ++ E L A++E R H+ ++ + L QL SD E E ++ E+
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1893
Query: 273 KEAEEEQEEEE-----AEEDLQCAHPCDAPKLISQ-----EALLHQHHCPQLEALQEKLR 322
+ Q EEE A + A + + + E L +LEA +++
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953
Query: 323 LLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEV--LVLRLENYERQ 380
EEE + E +L EE+ A Q+ A L EV L ++E R
Sbjct: 1954 AAEEERRRREAEERVQKSLAAEEE-----------AARQRKAALEEVERLKAKVEEARRL 2002
Query: 381 QQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDT 440
++ + A+ L+L Q + L ++ A ++ + + + + + RG+
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK-EQELQQTLQQEQSVLDQLRGEA 2061
Query: 441 SSLR------YDFRYSEDREQV---RGFEAEEGLMLAADIM---RGEDFTPAEEFVPQEE 488
+ R + R +RE R E E L +A+ R + AE+ + E
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2121
Query: 489 LGAAKKVPAEEGVMEEAELVSEETE 513
AA++ AE+ + + + E E
Sbjct: 2122 QEAARRAQAEQAALRQKQAADAEME 2146
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/298 (25%), Positives = 120/298 (40%), Gaps = 49/298 (16%)
Query: 248 LRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLH 307
L + ++ S++ E+EE E++ AEE + E E L+ Q A H
Sbjct: 1307 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR---------QLAEAH 1357
Query: 308 QHHCPQLEALQEKLRLLEEENHQLREEAS-----QLDTLEDEEQMLILECVEQFSEASQQ 362
Q E ++L+ +E REEA+ Q ++++E Q L + E +A +
Sbjct: 1358 AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKAR 1416
Query: 363 MAELSEVLVLRLENYERQQQEVARLQAQVLKLQQ----------RCRMETLPGFQETLAE 412
AE +E LR+E ++ V RLQ + + Q+ R R E Q+ A+
Sbjct: 1417 QAEAAERSRLRIE----EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQ 1471
Query: 413 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM 472
E LRR + D E + + R RE+ R +A E L L A+
Sbjct: 1472 EEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE-- 1524
Query: 473 RGEDFTPAEEFVPQEELGAAKKVPAEEGVME---EAELVSEE---TEGWEEVELELDE 524
AE + Q E+ A++V + EAEL S+ E ++E L E
Sbjct: 1525 ------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576
Score = 40.0 bits (92), Expect = 0.006
Identities = 72/325 (22%), Positives = 129/325 (39%), Gaps = 58/325 (17%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALL-GSAKEEILYLRHQVNLRDELLQLYS 257
+ ER+ + + V+Q + +E K L G+A++ + EL++L +
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-------AEQELIRLRA 1698
Query: 258 DSDEEDEDEEEEEEE------KEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHC 311
++++ ++ + EEE + A Q+ +E E +L + L++ +A +
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR-AEMEVLLASKARAEEESR 1757
Query: 312 PQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLV 371
E +++L +L EEA++L L +E ++ +Q+AE
Sbjct: 1758 STSEKSKQRLEAEAGRFRELAEEAARLRALAEE------------AKRQRQLAE------ 1799
Query: 372 LRLENYERQQQEVARLQAQVLKL---QQRCRMETLPGFQETLAEELRTSLRRMISDPVYF 428
E+ RQ+ E R+ A+ L R + E +E AE R LRR+ D +
Sbjct: 1800 ---EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1854
Query: 429 MERNYEMP---RGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVP 485
R E + D R + D E E ++GL+ ED V
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLV--------EDTLRQRRQVE 1902
Query: 486 QEELGAAKKVPAEEGVMEEAELVSE 510
+E L A K E+ +AEL E
Sbjct: 1903 EEIL--ALKASFEKAAAGKAELELE 1925
Score = 38.9 bits (89), Expect = 0.013
Identities = 73/361 (20%), Positives = 145/361 (40%), Gaps = 51/361 (14%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E ++ AR ++ +++ + +EE ++ L A E R + EL L + ++
Sbjct: 1408 EAEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATE-----RQRGGAEGELQALRARAE 1461
Query: 261 EEDEDEEEEEEEKEA------EEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQL 314
E + + + +EE E +E Q + +AE +L +A ++ L +L
Sbjct: 1462 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1521
Query: 315 EALQEKLRLLEEENHQLR-------------------------EEASQLDTLEDEEQMLI 349
+A + + RL + E + R E+ +QL+ EE + +
Sbjct: 1522 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1581
Query: 350 LECVEQFSEASQQMAELS---EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGF 406
+ E+ +QQ AE E LE ++ + E RL+ Q ++ Q+ +
Sbjct: 1582 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA- 1640
Query: 407 QETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLM 466
++ E R + RR ++ +R E+ + R + +E Q R +E +
Sbjct: 1641 EKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR---QLAEGTAQQRLAAEQELIR 1695
Query: 467 LAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
L A+ +GE + + +EEL ++ A + EL +E + E+E+ L
Sbjct: 1696 LRAETEQGEQ----QRQLLEEELARLQR-EAAAATQKRQELEAELAKVRAEMEVLLASKA 1750
Query: 527 R 527
R
Sbjct: 1751 R 1751
Score = 38.9 bits (89), Expect = 0.013
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 16/163 (9%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNL-RDELLQLY 256
LQ+E L V+Q +L E + ++ L S K+ +L + + +L QL+
Sbjct: 2440 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKDSLLQRERFIEQEKAKLEQLF 2498
Query: 257 SDSDEEDEDEEEEEEEKEAEEEQEEE----EAEEDLQCAHPCDAPKLISQEALLHQHHCP 312
D + + EE++ ++ + EQE + EE + H + QE L
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL------Q 2552
Query: 313 QLE-ALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVE 354
QLE +++ LL EEN +LRE QL LE++ + + E
Sbjct: 2553 QLEQQRRQQEELLAEENQRLRE---QLQLLEEQHRAALAHSEE 2592
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 57.4 bits (137), Expect = 4e-08
Identities = 71/309 (22%), Positives = 130/309 (42%), Gaps = 35/309 (11%)
Query: 237 EEILYLRHQVNLRDE----LLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH 292
EEI H+ L + L+Q ++ + + E E AE E+E+E+ +++ +
Sbjct: 2397 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2456
Query: 293 -PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILE 351
+ + + QE LL + Q L EK LL+ E + +E ++L+ L +E +
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQDEVAKAQQ 2515
Query: 352 CVEQFSEASQQMAELSEVLVLRLENYERQQQE----VARLQAQVLKLQQRCRMETLPGFQ 407
E+ QQM + + LV +E R+Q E V R Q ++ +L+Q+ R + +
Sbjct: 2516 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ-----E 2570
Query: 408 ETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLML 467
E LAEE + + + + +E + R +SE+ A + L
Sbjct: 2571 ELLAEE-----NQRLREQLQLLEEQH----------RAALAHSEE-VTASQVAATKTLPN 2614
Query: 468 AADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATR 527
D + G PA E P+ ++ + + + E L +EE + + +DE R
Sbjct: 2615 GRDALDG----PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2670
Query: 528 MNVVTSALE 536
V L+
Sbjct: 2671 REDVRHYLQ 2679
Score = 45.4 bits (106), Expect = 1e-04
Identities = 66/327 (20%), Positives = 138/327 (42%), Gaps = 36/327 (11%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E DL + + ++K+ ++E ++L+A E L+ Q EL Q +
Sbjct: 2284 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-------EAELLQQQ----KELAQEQARRL 2332
Query: 261 EEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEK 320
+ED+++ ++ +E + Q EAE Q +A +L + A + + E Q
Sbjct: 2333 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2392
Query: 321 LRLLEEENHQL-------REEASQLDTLE------DEEQMLILECVEQFSEASQQMAELS 367
+ EE +L +E+ + + TLE D + + E + + +++ + +
Sbjct: 2393 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2452
Query: 368 EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVY 427
++L L+ E + QQE + Q L+ ++L +E E+ + L ++ D V
Sbjct: 2453 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVA 2511
Query: 428 FMERNYEMPRGDTSSL---RYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFV 484
++ E + + R S + + R EAEEG+ + E+ E+
Sbjct: 2512 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR-----RKQEELQQLEQQR 2566
Query: 485 PQEELGAAKKVPAEEGVMEEAELVSEE 511
Q+E A++ + + E+ +L+ E+
Sbjct: 2567 RQQEELLAEE---NQRLREQLQLLEEQ 2590
Score = 44.3 bits (103), Expect = 3e-04
Identities = 63/269 (23%), Positives = 113/269 (42%), Gaps = 22/269 (8%)
Query: 217 QNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAE 276
+ +L + S +A G A+ E+ R + N D L S E+ E E + + AE
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEAARQRQLAAE 1964
Query: 277 EEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENH------- 329
EE+ EAEE +Q + + ++A L + +L+A E+ R L E
Sbjct: 1965 EERRRREAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQL 2022
Query: 330 QLREEASQ--LDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYER--QQQEVA 385
QL +EA+Q L E + + ++ + QQ + + L E R ++ E A
Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2082
Query: 386 RLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPR---GDTSS 442
R+QA+ Q R ++E +++ E+ + + + E E R + ++
Sbjct: 2083 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2142
Query: 443 LRYDFRYSEDREQVRGFEAEEGLMLAADI 471
LR + E+ + F AE+ L A +
Sbjct: 2143 LRQKQAADAEMEKHKKF-AEQTLRQKAQV 2170
Score = 44.3 bits (103), Expect = 3e-04
Identities = 84/374 (22%), Positives = 148/374 (39%), Gaps = 46/374 (12%)
Query: 200 RERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDS 259
RER +AR Q + ++ K A KE+ L Q L+ E L
Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL----QQTLQQEQSVLDQLR 2066
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQE 319
E + EE +EA + E E A+ Q + + + Q A Q +A E
Sbjct: 2067 GEAEAARRAAEEAEEARVQAEREAAQSRRQV----EEAERLKQSAEEQAQARAQAQAAAE 2122
Query: 320 KLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS-QQMAELSEVLV---LRLE 375
KLR E+ R +A Q + + +E ++F+E + +Q A++ + L L+LE
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182
Query: 376 NYERQQ----QEVARLQAQVLKLQQ------------RCRMETLPGFQETLAEELRTSLR 419
+ Q+ +E+ RL+A+ + + R +ME L + + E R +
Sbjct: 2183 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2242
Query: 420 RMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGL---------MLAAD 470
R + F++ E + +++ ++R AEE L ML
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKEK 2301
Query: 471 IMRGEDFT----PAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
+ ++ T AE Q+EL + +E + A+ ++EET+G++ EA
Sbjct: 2302 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAE 2357
Query: 527 RMNVVTSALEASGL 540
R + + EA L
Sbjct: 2358 RQRQLEMSAEAERL 2371
Score = 43.1 bits (100), Expect = 7e-04
Identities = 76/339 (22%), Positives = 145/339 (42%), Gaps = 35/339 (10%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYS 257
L+++R L A ++ ++ + +++ + E ++ + + + + ++++EL QL
Sbjct: 1355 LEKQRQLAEAHAQAKAQAEREAKELQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQ 1413
Query: 258 DSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCP--QLE 315
S+ E + + + E E + EEE + EA Q +L+
Sbjct: 1414 SSEAEIQAKARQAEAAERSRLRIEEEIR-----------VVRLQLEATERQRGGAEGELQ 1462
Query: 316 ALQEKLRLLEEENHQLREEASQL-DTLEDEEQ------MLILECVEQFSEAS---QQMAE 365
AL+ + E + Q +EEA +L ++DE Q + + V+ +EA+ Q+ +
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522
Query: 366 LSEVLVLRLENYER--QQQEVARL-QAQV-LKLQQRCRMETLPGFQETLAEELRTSLRRM 421
E L L+ E ER +Q EV R Q QV L+ QR L + + AE+ R +
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582
Query: 422 ISDPVYFMERNYEMPR-----GDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGED 476
+ V + E R + R + +R Q++ EA + A ++ + +
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1642
Query: 477 FTPAEEFVPQEEL--GAAKKVPAEEGVMEEAELVSEETE 513
AE +EE A ++ AEE + + EL +E E
Sbjct: 1643 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1681
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 44/325 (13%)
Query: 221 LMEENSKLEALLGSAKEEILYLR--------HQVNLRDELLQLYSDSDEEDEDEEEEEEE 272
L E+ ++ E L A++E R H+ ++ + L QL SD E E ++ E+
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1901
Query: 273 KEAEEEQEEEE-----AEEDLQCAHPCDAPKLISQ-----EALLHQHHCPQLEALQEKLR 322
+ Q EEE A + A + + + E L +LEA +++
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961
Query: 323 LLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEV--LVLRLENYERQ 380
EEE + E +L EE+ A Q+ A L EV L ++E R
Sbjct: 1962 AAEEERRRREAEERVQKSLAAEEE-----------AARQRKAALEEVERLKAKVEEARRL 2010
Query: 381 QQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDT 440
++ + A+ L+L Q + L ++ A ++ + + + + + RG+
Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK-EQELQQTLQQEQSVLDQLRGEA 2069
Query: 441 SSLR------YDFRYSEDREQV---RGFEAEEGLMLAADIM---RGEDFTPAEEFVPQEE 488
+ R + R +RE R E E L +A+ R + AE+ + E
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2129
Query: 489 LGAAKKVPAEEGVMEEAELVSEETE 513
AA++ AE+ + + + E E
Sbjct: 2130 QEAARRAQAEQAALRQKQAADAEME 2154
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/298 (25%), Positives = 120/298 (40%), Gaps = 49/298 (16%)
Query: 248 LRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLH 307
L + ++ S++ E+EE E++ AEE + E E L+ Q A H
Sbjct: 1315 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR---------QLAEAH 1365
Query: 308 QHHCPQLEALQEKLRLLEEENHQLREEAS-----QLDTLEDEEQMLILECVEQFSEASQQ 362
Q E ++L+ +E REEA+ Q ++++E Q L + E +A +
Sbjct: 1366 AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKAR 1424
Query: 363 MAELSEVLVLRLENYERQQQEVARLQAQVLKLQQ----------RCRMETLPGFQETLAE 412
AE +E LR+E ++ V RLQ + + Q+ R R E Q+ A+
Sbjct: 1425 QAEAAERSRLRIE----EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQ 1479
Query: 413 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM 472
E LRR + D E + + R RE+ R +A E L L A+
Sbjct: 1480 EEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE-- 1532
Query: 473 RGEDFTPAEEFVPQEELGAAKKVPAEEGVME---EAELVSEE---TEGWEEVELELDE 524
AE + Q E+ A++V + EAEL S+ E ++E L E
Sbjct: 1533 ------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1584
Score = 40.0 bits (92), Expect = 0.006
Identities = 72/325 (22%), Positives = 129/325 (39%), Gaps = 58/325 (17%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALL-GSAKEEILYLRHQVNLRDELLQLYS 257
+ ER+ + + V+Q + +E K L G+A++ + EL++L +
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-------AEQELIRLRA 1706
Query: 258 DSDEEDEDEEEEEEE------KEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHC 311
++++ ++ + EEE + A Q+ +E E +L + L++ +A +
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR-AEMEVLLASKARAEEESR 1765
Query: 312 PQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLV 371
E +++L +L EEA++L L +E ++ +Q+AE
Sbjct: 1766 STSEKSKQRLEAEAGRFRELAEEAARLRALAEE------------AKRQRQLAE------ 1807
Query: 372 LRLENYERQQQEVARLQAQVLKL---QQRCRMETLPGFQETLAEELRTSLRRMISDPVYF 428
E+ RQ+ E R+ A+ L R + E +E AE R LRR+ D +
Sbjct: 1808 ---EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1862
Query: 429 MERNYEMP---RGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVP 485
R E + D R + D E E ++GL+ ED V
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLV--------EDTLRQRRQVE 1910
Query: 486 QEELGAAKKVPAEEGVMEEAELVSE 510
+E L A K E+ +AEL E
Sbjct: 1911 EEIL--ALKASFEKAAAGKAELELE 1933
Score = 38.9 bits (89), Expect = 0.013
Identities = 73/361 (20%), Positives = 145/361 (40%), Gaps = 51/361 (14%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E ++ AR ++ +++ + +EE ++ L A E R + EL L + ++
Sbjct: 1416 EAEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATE-----RQRGGAEGELQALRARAE 1469
Query: 261 EEDEDEEEEEEEKEA------EEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQL 314
E + + + +EE E +E Q + +AE +L +A ++ L +L
Sbjct: 1470 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1529
Query: 315 EALQEKLRLLEEENHQLR-------------------------EEASQLDTLEDEEQMLI 349
+A + + RL + E + R E+ +QL+ EE + +
Sbjct: 1530 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1589
Query: 350 LECVEQFSEASQQMAELS---EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGF 406
+ E+ +QQ AE E LE ++ + E RL+ Q ++ Q+ +
Sbjct: 1590 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA- 1648
Query: 407 QETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLM 466
++ E R + RR ++ +R E+ + R + +E Q R +E +
Sbjct: 1649 EKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR---QLAEGTAQQRLAAEQELIR 1703
Query: 467 LAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
L A+ +GE + + +EEL ++ A + EL +E + E+E+ L
Sbjct: 1704 LRAETEQGEQ----QRQLLEEELARLQR-EAAAATQKRQELEAELAKVRAEMEVLLASKA 1758
Query: 527 R 527
R
Sbjct: 1759 R 1759
Score = 38.9 bits (89), Expect = 0.013
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 16/163 (9%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNL-RDELLQLY 256
LQ+E L V+Q +L E + ++ L S K+ +L + + +L QL+
Sbjct: 2448 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKDSLLQRERFIEQEKAKLEQLF 2506
Query: 257 SDSDEEDEDEEEEEEEKEAEEEQEEE----EAEEDLQCAHPCDAPKLISQEALLHQHHCP 312
D + + EE++ ++ + EQE + EE + H + QE L
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL------Q 2560
Query: 313 QLE-ALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVE 354
QLE +++ LL EEN +LRE QL LE++ + + E
Sbjct: 2561 QLEQQRRQQEELLAEENQRLRE---QLQLLEEQHRAALAHSEE 2600
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 57.4 bits (137), Expect = 4e-08
Identities = 71/309 (22%), Positives = 130/309 (42%), Gaps = 35/309 (11%)
Query: 237 EEILYLRHQVNLRDE----LLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH 292
EEI H+ L + L+Q ++ + + E E AE E+E+E+ +++ +
Sbjct: 2438 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2497
Query: 293 -PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILE 351
+ + + QE LL + Q L EK LL+ E + +E ++L+ L +E +
Sbjct: 2498 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQDEVAKAQQ 2556
Query: 352 CVEQFSEASQQMAELSEVLVLRLENYERQQQE----VARLQAQVLKLQQRCRMETLPGFQ 407
E+ QQM + + LV +E R+Q E V R Q ++ +L+Q+ R + +
Sbjct: 2557 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ-----E 2611
Query: 408 ETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLML 467
E LAEE + + + + +E + R +SE+ A + L
Sbjct: 2612 ELLAEE-----NQRLREQLQLLEEQH----------RAALAHSEE-VTASQVAATKTLPN 2655
Query: 468 AADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATR 527
D + G PA E P+ ++ + + + E L +EE + + +DE R
Sbjct: 2656 GRDALDG----PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELAR 2711
Query: 528 MNVVTSALE 536
V L+
Sbjct: 2712 REDVRHYLQ 2720
Score = 45.4 bits (106), Expect = 1e-04
Identities = 66/327 (20%), Positives = 138/327 (42%), Gaps = 36/327 (11%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E DL + + ++K+ ++E ++L+A E L+ Q EL Q +
Sbjct: 2325 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-------EAELLQQQ----KELAQEQARRL 2373
Query: 261 EEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEK 320
+ED+++ ++ +E + Q EAE Q +A +L + A + + E Q
Sbjct: 2374 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2433
Query: 321 LRLLEEENHQL-------REEASQLDTLE------DEEQMLILECVEQFSEASQQMAELS 367
+ EE +L +E+ + + TLE D + + E + + +++ + +
Sbjct: 2434 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2493
Query: 368 EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVY 427
++L L+ E + QQE + Q L+ ++L +E E+ + L ++ D V
Sbjct: 2494 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVA 2552
Query: 428 FMERNYEMPRGDTSSL---RYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFV 484
++ E + + R S + + R EAEEG+ + E+ E+
Sbjct: 2553 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR-----RKQEELQQLEQQR 2607
Query: 485 PQEELGAAKKVPAEEGVMEEAELVSEE 511
Q+E A++ + + E+ +L+ E+
Sbjct: 2608 RQQEELLAEE---NQRLREQLQLLEEQ 2631
Score = 44.3 bits (103), Expect = 3e-04
Identities = 63/269 (23%), Positives = 113/269 (42%), Gaps = 22/269 (8%)
Query: 217 QNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAE 276
+ +L + S +A G A+ E+ R + N D L S E+ E E + + AE
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEAARQRQLAAE 2005
Query: 277 EEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENH------- 329
EE+ EAEE +Q + + ++A L + +L+A E+ R L E
Sbjct: 2006 EERRRREAEERVQKSLAAEEEAARQRKAALEE--VERLKAKVEEARRLRERAEQESARQL 2063
Query: 330 QLREEASQ--LDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYER--QQQEVA 385
QL +EA+Q L E + + ++ + QQ + + L E R ++ E A
Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2123
Query: 386 RLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPR---GDTSS 442
R+QA+ Q R ++E +++ E+ + + + E E R + ++
Sbjct: 2124 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2183
Query: 443 LRYDFRYSEDREQVRGFEAEEGLMLAADI 471
LR + E+ + F AE+ L A +
Sbjct: 2184 LRQKQAADAEMEKHKKF-AEQTLRQKAQV 2211
Score = 44.3 bits (103), Expect = 3e-04
Identities = 84/374 (22%), Positives = 148/374 (39%), Gaps = 46/374 (12%)
Query: 200 RERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDS 259
RER +AR Q + ++ K A KE+ L Q L+ E L
Sbjct: 2052 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL----QQTLQQEQSVLDQLR 2107
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQE 319
E + EE +EA + E E A+ Q + + + Q A Q +A E
Sbjct: 2108 GEAEAARRAAEEAEEARVQAEREAAQSRRQV----EEAERLKQSAEEQAQARAQAQAAAE 2163
Query: 320 KLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS-QQMAELSEVLV---LRLE 375
KLR E+ R +A Q + + +E ++F+E + +Q A++ + L L+LE
Sbjct: 2164 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2223
Query: 376 NYERQQ----QEVARLQAQVLKLQQ------------RCRMETLPGFQETLAEELRTSLR 419
+ Q+ +E+ RL+A+ + + R +ME L + + E R +
Sbjct: 2224 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2283
Query: 420 RMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGL---------MLAAD 470
R + F++ E + +++ ++R AEE L ML
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKEK 2342
Query: 471 IMRGEDFT----PAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
+ ++ T AE Q+EL + +E + A+ ++EET+G++ EA
Sbjct: 2343 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAE 2398
Query: 527 RMNVVTSALEASGL 540
R + + EA L
Sbjct: 2399 RQRQLEMSAEAERL 2412
Score = 43.1 bits (100), Expect = 7e-04
Identities = 76/339 (22%), Positives = 145/339 (42%), Gaps = 35/339 (10%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYS 257
L+++R L A ++ ++ + +++ + E ++ + + + + ++++EL QL
Sbjct: 1396 LEKQRQLAEAHAQAKAQAEREAKELQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQ 1454
Query: 258 DSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCP--QLE 315
S+ E + + + E E + EEE + EA Q +L+
Sbjct: 1455 SSEAEIQAKARQAEAAERSRLRIEEEIR-----------VVRLQLEATERQRGGAEGELQ 1503
Query: 316 ALQEKLRLLEEENHQLREEASQL-DTLEDEEQ------MLILECVEQFSEAS---QQMAE 365
AL+ + E + Q +EEA +L ++DE Q + + V+ +EA+ Q+ +
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563
Query: 366 LSEVLVLRLENYER--QQQEVARL-QAQV-LKLQQRCRMETLPGFQETLAEELRTSLRRM 421
E L L+ E ER +Q EV R Q QV L+ QR L + + AE+ R +
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623
Query: 422 ISDPVYFMERNYEMPR-----GDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGED 476
+ V + E R + R + +R Q++ EA + A ++ + +
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1683
Query: 477 FTPAEEFVPQEEL--GAAKKVPAEEGVMEEAELVSEETE 513
AE +EE A ++ AEE + + EL +E E
Sbjct: 1684 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1722
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 44/325 (13%)
Query: 221 LMEENSKLEALLGSAKEEILYLR--------HQVNLRDELLQLYSDSDEEDEDEEEEEEE 272
L E+ ++ E L A++E R H+ ++ + L QL SD E E ++ E+
Sbjct: 1883 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1942
Query: 273 KEAEEEQEEEE-----AEEDLQCAHPCDAPKLISQ-----EALLHQHHCPQLEALQEKLR 322
+ Q EEE A + A + + + E L +LEA +++
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002
Query: 323 LLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEV--LVLRLENYERQ 380
EEE + E +L EE+ A Q+ A L EV L ++E R
Sbjct: 2003 AAEEERRRREAEERVQKSLAAEEE-----------AARQRKAALEEVERLKAKVEEARRL 2051
Query: 381 QQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDT 440
++ + A+ L+L Q + L ++ A ++ + + + + + RG+
Sbjct: 2052 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK-EQELQQTLQQEQSVLDQLRGEA 2110
Query: 441 SSLR------YDFRYSEDREQV---RGFEAEEGLMLAADIM---RGEDFTPAEEFVPQEE 488
+ R + R +RE R E E L +A+ R + AE+ + E
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2170
Query: 489 LGAAKKVPAEEGVMEEAELVSEETE 513
AA++ AE+ + + + E E
Sbjct: 2171 QEAARRAQAEQAALRQKQAADAEME 2195
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/298 (25%), Positives = 120/298 (40%), Gaps = 49/298 (16%)
Query: 248 LRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLH 307
L + ++ S++ E+EE E++ AEE + E E L+ Q A H
Sbjct: 1356 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR---------QLAEAH 1406
Query: 308 QHHCPQLEALQEKLRLLEEENHQLREEAS-----QLDTLEDEEQMLILECVEQFSEASQQ 362
Q E ++L+ +E REEA+ Q ++++E Q L + E +A +
Sbjct: 1407 AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKAR 1465
Query: 363 MAELSEVLVLRLENYERQQQEVARLQAQVLKLQQ----------RCRMETLPGFQETLAE 412
AE +E LR+E ++ V RLQ + + Q+ R R E Q+ A+
Sbjct: 1466 QAEAAERSRLRIE----EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQ 1520
Query: 413 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM 472
E LRR + D E + + R RE+ R +A E L L A+
Sbjct: 1521 EEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE-- 1573
Query: 473 RGEDFTPAEEFVPQEELGAAKKVPAEEGVME---EAELVSEE---TEGWEEVELELDE 524
AE + Q E+ A++V + EAEL S+ E ++E L E
Sbjct: 1574 ------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625
Score = 40.0 bits (92), Expect = 0.006
Identities = 72/325 (22%), Positives = 129/325 (39%), Gaps = 58/325 (17%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALL-GSAKEEILYLRHQVNLRDELLQLYS 257
+ ER+ + + V+Q + +E K L G+A++ + EL++L +
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA-------AEQELIRLRA 1747
Query: 258 DSDEEDEDEEEEEEE------KEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHC 311
++++ ++ + EEE + A Q+ +E E +L + L++ +A +
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR-AEMEVLLASKARAEEESR 1806
Query: 312 PQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLV 371
E +++L +L EEA++L L +E ++ +Q+AE
Sbjct: 1807 STSEKSKQRLEAEAGRFRELAEEAARLRALAEE------------AKRQRQLAE------ 1848
Query: 372 LRLENYERQQQEVARLQAQVLKL---QQRCRMETLPGFQETLAEELRTSLRRMISDPVYF 428
E+ RQ+ E R+ A+ L R + E +E AE R LRR+ D +
Sbjct: 1849 ---EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1903
Query: 429 MERNYEMP---RGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVP 485
R E + D R + D E E ++GL+ ED V
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLV--------EDTLRQRRQVE 1951
Query: 486 QEELGAAKKVPAEEGVMEEAELVSE 510
+E L A K E+ +AEL E
Sbjct: 1952 EEIL--ALKASFEKAAAGKAELELE 1974
Score = 38.9 bits (89), Expect = 0.013
Identities = 73/361 (20%), Positives = 145/361 (40%), Gaps = 51/361 (14%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSD 260
E ++ AR ++ +++ + +EE ++ L A E R + EL L + ++
Sbjct: 1457 EAEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATE-----RQRGGAEGELQALRARAE 1510
Query: 261 EEDEDEEEEEEEKEA------EEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQL 314
E + + + +EE E +E Q + +AE +L +A ++ L +L
Sbjct: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570
Query: 315 EALQEKLRLLEEENHQLR-------------------------EEASQLDTLEDEEQMLI 349
+A + + RL + E + R E+ +QL+ EE + +
Sbjct: 1571 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630
Query: 350 LECVEQFSEASQQMAELS---EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGF 406
+ E+ +QQ AE E LE ++ + E RL+ Q ++ Q+ +
Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA- 1689
Query: 407 QETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLM 466
++ E R + RR ++ +R E+ + R + +E Q R +E +
Sbjct: 1690 EKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR---QLAEGTAQQRLAAEQELIR 1744
Query: 467 LAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEAT 526
L A+ +GE + + +EEL ++ A + EL +E + E+E+ L
Sbjct: 1745 LRAETEQGEQ----QRQLLEEELARLQR-EAAAATQKRQELEAELAKVRAEMEVLLASKA 1799
Query: 527 R 527
R
Sbjct: 1800 R 1800
Score = 38.9 bits (89), Expect = 0.013
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 16/163 (9%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNL-RDELLQLY 256
LQ+E L V+Q +L E + ++ L S K+ +L + + +L QL+
Sbjct: 2489 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKDSLLQRERFIEQEKAKLEQLF 2547
Query: 257 SDSDEEDEDEEEEEEEKEAEEEQEEE----EAEEDLQCAHPCDAPKLISQEALLHQHHCP 312
D + + EE++ ++ + EQE + EE + H + QE L
Sbjct: 2548 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL------Q 2601
Query: 313 QLE-ALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVE 354
QLE +++ LL EEN +LRE QL LE++ + + E
Sbjct: 2602 QLEQQRRQQEELLAEENQRLRE---QLQLLEEQHRAALAHSEE 2641
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 56.6 bits (135), Expect = 6e-08
Identities = 69/285 (24%), Positives = 118/285 (41%), Gaps = 49/285 (17%)
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCD---APKLISQEALLHQHHCPQLEA 316
+E E+EE + E +EAEE +EE+ A ++ A P D +P+ ++E P++E
Sbjct: 1221 EERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKE--------PEVEE 1272
Query: 317 LQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLEN 376
+EK R + EE Q EE +L+ E EE+ +A+ + A+ ++
Sbjct: 1273 EEEKPR-VSEEQRQSEEEQQELEEPEPEEE----------EDAAAETAQ--------NDD 1313
Query: 377 YERQQQEVARLQAQVLK-LQQRCRMETL---PGFQETLAEELRTSLRRMISDPVYF-MER 431
++ ++ L++ K L+++ E + PG QE+ + R I D ++
Sbjct: 1314 HDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDS 1373
Query: 432 NYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGA 491
E P DTS + SED + EE + L EE +P EL
Sbjct: 1374 EEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIEL-----------KEEEEIPHSELDL 1422
Query: 492 AKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVTSALE 536
+ EE+ SE +++ E L + T A E
Sbjct: 1423 ETVQAVQSLTQEES---SEHEGAYQDCEETLAACQTLQSYTQADE 1464
Score = 35.8 bits (81), Expect = 0.11
Identities = 32/112 (28%), Positives = 53/112 (47%), Gaps = 16/112 (14%)
Query: 258 DSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEAL 317
D+D+ED+ E ++KE EE+ E+ +E+ P + QE+ L + ++
Sbjct: 1315 DADDEDDGHLESTKKKELEEQPTREDVKEE---------PGV--QESFLDAN----MQKS 1359
Query: 318 QEKLRLLEEENHQLREEASQLDTLEDEEQMLILE-CVEQFSEASQQMAELSE 368
+EK++ EE EE DT EQM E E+ S +++ EL E
Sbjct: 1360 REKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKE 1411
Score = 33.5 bits (75), Expect = 0.57
Identities = 38/163 (23%), Positives = 71/163 (43%), Gaps = 15/163 (9%)
Query: 259 SDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQ-CAHPCDAPKLISQEALLHQHHCPQLEAL 317
S+E+ + EEE++E +E E E+EE+ A E Q H D E H + E
Sbjct: 1280 SEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDAD------DEDDGHLESTKKKELE 1333
Query: 318 QEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENY 377
++ R +E ++E + + E++ E E SE Q + S V+ ++
Sbjct: 1334 EQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTS-VVSEQMAGS 1392
Query: 378 ERQQQEVARLQAQVLKLQQ-------RCRMETLPGFQETLAEE 413
E +E + + ++++L++ +ET+ Q EE
Sbjct: 1393 EDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEE 1435
Score = 29.6 bits (65), Expect = 8.2
Identities = 45/204 (22%), Positives = 82/204 (40%), Gaps = 14/204 (6%)
Query: 244 HQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQE 303
H ++ E + D EED +EE E +EE+E +E DL+ + L +E
Sbjct: 1380 HDTSVVSEQMAGSEDDHEED--SHTKEELIELKEEEEIPHSELDLETVQAVQS--LTQEE 1435
Query: 304 ALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLED---EEQMLILECVEQFSEAS 360
+ H+ E + L +++ +E Q+ +ED E + V+ S S
Sbjct: 1436 SSEHEGAYQDCEETLAACQTL--QSYTQADEDPQMSMVEDCHASEHNSPISSVQ--SHPS 1491
Query: 361 QQMAELSEVLVLRLEN-YERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLR 419
Q + +S V LE+ Y + E L A ++ + M +P + + + +
Sbjct: 1492 QSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFS 1551
Query: 420 RMISDPVYFMERNYEMPRGDTSSL 443
+ S + NYE P S++
Sbjct: 1552 DLGS--IESTTENYENPSSYDSTM 1573
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 56.6 bits (135), Expect = 6e-08
Identities = 69/285 (24%), Positives = 118/285 (41%), Gaps = 49/285 (17%)
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCD---APKLISQEALLHQHHCPQLEA 316
+E E+EE + E +EAEE +EE+ A ++ A P D +P+ ++E P++E
Sbjct: 1221 EERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKE--------PEVEE 1272
Query: 317 LQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLEN 376
+EK R + EE Q EE +L+ E EE+ +A+ + A+ ++
Sbjct: 1273 EEEKPR-VSEEQRQSEEEQQELEEPEPEEE----------EDAAAETAQ--------NDD 1313
Query: 377 YERQQQEVARLQAQVLK-LQQRCRMETL---PGFQETLAEELRTSLRRMISDPVYF-MER 431
++ ++ L++ K L+++ E + PG QE+ + R I D ++
Sbjct: 1314 HDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDS 1373
Query: 432 NYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGA 491
E P DTS + SED + EE + L EE +P EL
Sbjct: 1374 EEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIEL-----------KEEEEIPHSELDL 1422
Query: 492 AKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVTSALE 536
+ EE+ SE +++ E L + T A E
Sbjct: 1423 ETVQAVQSLTQEES---SEHEGAYQDCEETLAACQTLQSYTQADE 1464
Score = 35.8 bits (81), Expect = 0.11
Identities = 32/112 (28%), Positives = 53/112 (47%), Gaps = 16/112 (14%)
Query: 258 DSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEAL 317
D+D+ED+ E ++KE EE+ E+ +E+ P + QE+ L + ++
Sbjct: 1315 DADDEDDGHLESTKKKELEEQPTREDVKEE---------PGV--QESFLDAN----MQKS 1359
Query: 318 QEKLRLLEEENHQLREEASQLDTLEDEEQMLILE-CVEQFSEASQQMAELSE 368
+EK++ EE EE DT EQM E E+ S +++ EL E
Sbjct: 1360 REKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKE 1411
Score = 33.5 bits (75), Expect = 0.57
Identities = 38/163 (23%), Positives = 71/163 (43%), Gaps = 15/163 (9%)
Query: 259 SDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQ-CAHPCDAPKLISQEALLHQHHCPQLEAL 317
S+E+ + EEE++E +E E E+EE+ A E Q H D E H + E
Sbjct: 1280 SEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDAD------DEDDGHLESTKKKELE 1333
Query: 318 QEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENY 377
++ R +E ++E + + E++ E E SE Q + S V+ ++
Sbjct: 1334 EQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTS-VVSEQMAGS 1392
Query: 378 ERQQQEVARLQAQVLKLQQ-------RCRMETLPGFQETLAEE 413
E +E + + ++++L++ +ET+ Q EE
Sbjct: 1393 EDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEE 1435
Score = 29.6 bits (65), Expect = 8.2
Identities = 45/204 (22%), Positives = 82/204 (40%), Gaps = 14/204 (6%)
Query: 244 HQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQE 303
H ++ E + D EED +EE E +EE+E +E DL+ + L +E
Sbjct: 1380 HDTSVVSEQMAGSEDDHEED--SHTKEELIELKEEEEIPHSELDLETVQAVQS--LTQEE 1435
Query: 304 ALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLED---EEQMLILECVEQFSEAS 360
+ H+ E + L +++ +E Q+ +ED E + V+ S S
Sbjct: 1436 SSEHEGAYQDCEETLAACQTL--QSYTQADEDPQMSMVEDCHASEHNSPISSVQ--SHPS 1491
Query: 361 QQMAELSEVLVLRLEN-YERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLR 419
Q + +S V LE+ Y + E L A ++ + M +P + + + +
Sbjct: 1492 QSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFS 1551
Query: 420 RMISDPVYFMERNYEMPRGDTSSL 443
+ S + NYE P S++
Sbjct: 1552 DLGS--IESTTENYENPSSYDSTM 1573
>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 56.6 bits (135), Expect = 6e-08
Identities = 69/285 (24%), Positives = 118/285 (41%), Gaps = 49/285 (17%)
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCD---APKLISQEALLHQHHCPQLEA 316
+E E+EE + E +EAEE +EE+ A ++ A P D +P+ ++E P++E
Sbjct: 1221 EERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKE--------PEVEE 1272
Query: 317 LQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLEN 376
+EK R + EE Q EE +L+ E EE+ +A+ + A+ ++
Sbjct: 1273 EEEKPR-VSEEQRQSEEEQQELEEPEPEEE----------EDAAAETAQ--------NDD 1313
Query: 377 YERQQQEVARLQAQVLK-LQQRCRMETL---PGFQETLAEELRTSLRRMISDPVYF-MER 431
++ ++ L++ K L+++ E + PG QE+ + R I D ++
Sbjct: 1314 HDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDS 1373
Query: 432 NYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGA 491
E P DTS + SED + EE + L EE +P EL
Sbjct: 1374 EEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIEL-----------KEEEEIPHSELDL 1422
Query: 492 AKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVTSALE 536
+ EE+ SE +++ E L + T A E
Sbjct: 1423 ETVQAVQSLTQEES---SEHEGAYQDCEETLAACQTLQSYTQADE 1464
Score = 35.8 bits (81), Expect = 0.11
Identities = 32/112 (28%), Positives = 53/112 (47%), Gaps = 16/112 (14%)
Query: 258 DSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEAL 317
D+D+ED+ E ++KE EE+ E+ +E+ P + QE+ L + ++
Sbjct: 1315 DADDEDDGHLESTKKKELEEQPTREDVKEE---------PGV--QESFLDAN----MQKS 1359
Query: 318 QEKLRLLEEENHQLREEASQLDTLEDEEQMLILE-CVEQFSEASQQMAELSE 368
+EK++ EE EE DT EQM E E+ S +++ EL E
Sbjct: 1360 REKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKE 1411
Score = 33.5 bits (75), Expect = 0.57
Identities = 38/163 (23%), Positives = 71/163 (43%), Gaps = 15/163 (9%)
Query: 259 SDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQ-CAHPCDAPKLISQEALLHQHHCPQLEAL 317
S+E+ + EEE++E +E E E+EE+ A E Q H D E H + E
Sbjct: 1280 SEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDAD------DEDDGHLESTKKKELE 1333
Query: 318 QEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENY 377
++ R +E ++E + + E++ E E SE Q + S V+ ++
Sbjct: 1334 EQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTS-VVSEQMAGS 1392
Query: 378 ERQQQEVARLQAQVLKLQQ-------RCRMETLPGFQETLAEE 413
E +E + + ++++L++ +ET+ Q EE
Sbjct: 1393 EDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEE 1435
Score = 29.6 bits (65), Expect = 8.2
Identities = 45/204 (22%), Positives = 82/204 (40%), Gaps = 14/204 (6%)
Query: 244 HQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQE 303
H ++ E + D EED +EE E +EE+E +E DL+ + L +E
Sbjct: 1380 HDTSVVSEQMAGSEDDHEED--SHTKEELIELKEEEEIPHSELDLETVQAVQS--LTQEE 1435
Query: 304 ALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLED---EEQMLILECVEQFSEAS 360
+ H+ E + L +++ +E Q+ +ED E + V+ S S
Sbjct: 1436 SSEHEGAYQDCEETLAACQTL--QSYTQADEDPQMSMVEDCHASEHNSPISSVQ--SHPS 1491
Query: 361 QQMAELSEVLVLRLEN-YERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLR 419
Q + +S V LE+ Y + E L A ++ + M +P + + + +
Sbjct: 1492 QSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFS 1551
Query: 420 RMISDPVYFMERNYEMPRGDTSSL 443
+ S + NYE P S++
Sbjct: 1552 DLGS--IESTTENYENPSSYDSTM 1573
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 56.2 bits (134), Expect = 8e-08
Identities = 60/313 (19%), Positives = 142/313 (45%), Gaps = 25/313 (7%)
Query: 212 QSLVKQNSVLMEENSKL---EALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEE 268
+ + +Q + E+ K+ E + G K+ + Q +R++ Q++ ++ + E++
Sbjct: 446 EKMQEQEEKIWEQEEKIRDQEEMWGQEKK----MWRQEKMREQEDQMWEQEEKMRDQEQK 501
Query: 269 --EEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEE 326
++EE+ E+++ E EE ++ + K+ QE + + Q QEK +E
Sbjct: 502 MWDQEERMWEQDERLREKEERMR-----EQKKMWQQEEKMREEKKTQE---QEKKTWDQE 553
Query: 327 ENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVAR 386
E + E + + EE+ ++ E E+ E ++M E E + + E + Q++++
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE 613
Query: 387 LQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYD 446
+ ++ + ++ +M+ E+++ +M E+ +M + +
Sbjct: 614 QEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQE 673
Query: 447 FRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEE--LGAAKKVPAEEGVMEE 504
+ E E+++G EE + + MRG++ E+ QEE G +K+ +E + E+
Sbjct: 674 EKMREQEEKMQG--QEEKMREQEEKMRGQE----EKMWGQEEKMWGQEEKMWGQEEMREK 727
Query: 505 AELVSEETEGWEE 517
E + ++ E +E
Sbjct: 728 EERIRDQKEKMQE 740
Score = 49.3 bits (116), Expect = 1e-05
Identities = 76/335 (22%), Positives = 139/335 (41%), Gaps = 41/335 (12%)
Query: 216 KQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEA 275
+Q + + +L +E+ LR Q LR++ Q+ ++ E EE+ E++E
Sbjct: 273 EQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEK 332
Query: 276 EEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEA 335
QEE E++ Q K+ QE + + E+LR EE + +
Sbjct: 333 MWRQEERLWEQEKQMRE--QEQKMRDQEERMWEQ--------DERLREKEERMREQEKMW 382
Query: 336 SQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLEN---YERQQQEVARLQAQVL 392
Q + +++EE+ I E ++ E + M E E + + EN E ++ + RL Q
Sbjct: 383 EQEEKMQEEER--IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE 440
Query: 393 KLQQRCRM-----------ETLPGFQETLAEE---LRTSLRRMISDPVYFME---RNYEM 435
KL ++ +M E + +E +E R R D ++ E R+ E
Sbjct: 441 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ 500
Query: 436 PRGDTSSLRYD----FRYSED--REQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEEL 489
D ++ R E+ REQ + ++ EE + E T +E +EE
Sbjct: 501 KMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEE 560
Query: 490 GAAKKVPAEEGVMEEAELVSEETEGWEEVELELDE 524
++ E+ + EE E++ E+ E +E E ++ E
Sbjct: 561 RMRER---EKKMREEEEMMREQEEKMQEQEEKMRE 592
Score = 38.5 bits (88), Expect = 0.018
Identities = 57/263 (21%), Positives = 117/263 (44%), Gaps = 32/263 (12%)
Query: 151 IRELEEALCPNLPPPVKKITQEDVKVMLYL-LEELLPPVWESVTYGMVLQRERDLNTAAR 209
+RE EE + KK+ Q++ K+ +E W+ +R R+ R
Sbjct: 516 LREKEERMREQ-----KKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR 570
Query: 210 IGQSLVK-QNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEE 268
+ +++ Q + E+ K+ E+ ++ Q E + + +EED+ +E+
Sbjct: 571 EEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQ 630
Query: 269 EE---EEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLE 325
EE E++E +EQEE+ E++ K+ QE + + +++ +EK+R E
Sbjct: 631 EEMMWEQEEKMQEQEEKMWEQE---------EKMREQEEKMREQE-EKMQGQEEKMREQE 680
Query: 326 E----ENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQ 381
E + ++RE+ ++ EE+M E E+ ++M E+ E ER +
Sbjct: 681 EKMQGQEEKMREQEEKM--RGQEEKMWGQE--EKMWGQEEKMWGQEEM----REKEERIR 732
Query: 382 QEVARLQAQVLKLQQRCRMETLP 404
+ ++Q ++ + ++RC LP
Sbjct: 733 DQKEKMQERLPEHEERCSEPCLP 755
Score = 30.0 bits (66), Expect = 6.3
Identities = 11/39 (28%), Positives = 23/39 (58%)
Query: 262 EDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLI 300
++E E+EE ++ +E+ +E E + +C+ PC P +
Sbjct: 721 QEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKV 759
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 55.8 bits (133), Expect = 1e-07
Identities = 76/313 (24%), Positives = 132/313 (42%), Gaps = 22/313 (7%)
Query: 197 VLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLY 256
V Q + + N + +S+ +Q +E N L L +E + ++ ++E L+
Sbjct: 159 VEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQ 218
Query: 257 SDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEA 316
+ E E+ E+EE+ E+E+ E EE L+ H +L QE L C Q E
Sbjct: 219 EERLCEQEERLREQEERLREQEERLCEQEERLR-EH---EERLCEQEERL----CEQEER 270
Query: 317 LQEKLRLLEEENHQLREEASQLDTLED---EEQMLILECVEQFSEASQQMAELSEVLV-- 371
L+E+ L E+ +L E+ +L E+ E++ + E E+ E +++ E E L
Sbjct: 271 LREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQ 330
Query: 372 LRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMER 431
+L ER +EV +L Q + +++ R+ E + E L R + ++ E
Sbjct: 331 EKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEELLEQERLRQQDERLWQQET 390
Query: 432 NYEMPR----GDTSSLRYDFRYSEDREQVRGFEA-----EEGLMLAADIMRGEDFTPAEE 482
E+ R L ++ Y + E GFE + L L + + AEE
Sbjct: 391 LQELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEE 450
Query: 483 FVPQEELGAAKKV 495
E AA+ V
Sbjct: 451 PRGSESAAAARPV 463
Score = 55.5 bits (132), Expect = 1e-07
Identities = 88/361 (24%), Positives = 151/361 (41%), Gaps = 56/361 (15%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVN-LRDELLQLYS 257
+++ +++ ++G+SL K + E + E G +K E L+ + N LR EL +
Sbjct: 122 EKKHEIHLVQKLGRSLFKLKNQTAEPLAP-EPPAGPSKVE--QLQDETNHLRKELESVGR 178
Query: 258 DSDEEDEDEE--------EEEEEKEAEEEQEEEEAEEDLQCAHPCD-APKLISQEALLHQ 308
E E+ + +EE +E EE E+E Q C+ +L QE L +
Sbjct: 179 QLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLRE 238
Query: 309 HH---CPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAE 365
C Q E L+E L E+ +L E+ +L E++ + E E+ E +++ E
Sbjct: 239 QEERLCEQEERLREHEERLCEQEERLCEQEERL----REQEERLHEQEERLCEQEERLRE 294
Query: 366 LSEVLVLRLENYERQQQEVARLQAQVLKLQQR-CRMETLPGFQETLAEELRTSLRRMISD 424
E L + E Q++ + + ++ + ++R C E LPG QE L EE+ L +
Sbjct: 295 QEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPG-QERLLEEVEKLLEQ---- 349
Query: 425 PVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFV 484
ER E EQ R E E L +++ E +E +
Sbjct: 350 -----ERRQE-------------------EQERLLERERLLEEVEELLEQERLRQQDERL 385
Query: 485 -PQEELGAAKKVPAEEGVME---EA--ELVSEETEGWEEVELELDEATRMNVVTSALEAS 538
QE L +++ E ++E EA E +E G+EE+ E ++ L+ S
Sbjct: 386 WQQETLQELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELKKS 445
Query: 539 G 539
G
Sbjct: 446 G 446
Score = 51.2 bits (121), Expect = 3e-06
Identities = 66/273 (24%), Positives = 110/273 (40%), Gaps = 24/273 (8%)
Query: 312 PQLEALQEKLRLLEEENHQLREEAS----QLDTLEDEEQMLILECVEQFSEASQQMAELS 367
P+ A K+ L++E + LR+E QL + QML L Q +Q L
Sbjct: 150 PEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLR 209
Query: 368 EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEE---LRTSLRRMISD 424
E E ER ++ RL+ Q +L+++ +E L E+ LR R+
Sbjct: 210 EQEERLREQEERLCEQEERLREQEERLREQ---------EERLCEQEERLREHEERLCEQ 260
Query: 425 PVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFV 484
E+ + + + R E E++R E EE L + +R ++ E+
Sbjct: 261 EERLCEQEERLREQEERLHEQEERLCEQEERLR--EQEERLCEQEERLREQEERLCEQEE 318
Query: 485 ----PQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVTSALEASGL 540
+E L +K+P +E ++EE E + E+ EE E L+ + V LE L
Sbjct: 319 RLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEELLEQERL 378
Query: 541 --GPSHLDMNYVLQQLANWQDAHYRRQLRWKML 571
L LQ+L ++ +L W+ L
Sbjct: 379 RQQDERLWQQETLQELERLRELERMLELGWEAL 411
>gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 479
Score = 55.8 bits (133), Expect = 1e-07
Identities = 81/325 (24%), Positives = 138/325 (42%), Gaps = 53/325 (16%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEE--------NSKLEALLGSA---KEEILYLRHQVN 247
+++ +++ ++G+SL K + E SK+E L ++E+ + Q+
Sbjct: 122 EKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQ 181
Query: 248 LRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLH 307
E Q+ S + E+ E+EE+ E+E+ E EE +L QE L
Sbjct: 182 AEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQEE-----------RLCEQEERL- 229
Query: 308 QHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILE---CVEQFSEASQQMA 364
C Q E L+E+ L E+ +L E+ +L E EE++ E C ++ +++
Sbjct: 230 ---CEQEERLREQEERLREQEERLHEQEERL--CEQEERLCEQEERLCEQEKLPGQERLL 284
Query: 365 ELSEVLVLRLENYERQQQEVARL--------QAQVLKLQQRCRMETLPGFQETLAEELRT 416
E E +L ER+Q+E RL + + L Q+R R + +Q+ EL
Sbjct: 285 EEVE----KLLEQERRQEEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLRELE- 339
Query: 417 SLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEA-----EEGLMLAADI 471
LR + + + +ER E+ R L ++ Y + E GFE + L L +
Sbjct: 340 RLREL--ERLRELERLRELER--MLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQV 395
Query: 472 MRGEDFTPAEEFVPQEELGAAKKVP 496
E AEE E AA+ VP
Sbjct: 396 KELEKSGGAEEPRGSESAAAARPVP 420
Score = 32.3 bits (72), Expect = 1.3
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 17/180 (9%)
Query: 361 QQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRR 420
+Q+ + + L LE+ RQ LQA+V Q + L QE E LR R
Sbjct: 160 EQLQDETNHLRKELESVGRQ------LQAEVENNQM---LSLLNRRQE---ERLREQEER 207
Query: 421 MISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPA 480
+ E+ + + + R E E++R E EE L + + ++
Sbjct: 208 LHEQEERLHEQEERLCEQEERLCEQEERLREQEERLR--EQEERLHEQEERLCEQEERLC 265
Query: 481 EEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVTSALEASGL 540
E+ +E L +K+P +E ++EE E + E+ EE E L+ ++ V LE L
Sbjct: 266 EQ---EERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLEQERL 322
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 55.5 bits (132), Expect = 1e-07
Identities = 79/343 (23%), Positives = 155/343 (45%), Gaps = 40/343 (11%)
Query: 212 QSLVKQNSVLMEENSK---LEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDE-DEE 267
+ + +Q ++ E+ K LE ++ +E+I L +++ ++++ + EE++ E+
Sbjct: 349 EKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 408
Query: 268 EEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEE 327
E+ +E+EA+ ++EE+ E + K+ QE +H+ QEK+R EEE
Sbjct: 409 EKRQEQEAKMWRQEEKIREQEEKIRE-QEKKMWRQEEKIHE---------QEKIR--EEE 456
Query: 328 NHQLREEA-SQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVAR 386
Q +EE Q + + ++E+ I E+ E Q+ E V R E Q+E R
Sbjct: 457 KRQEQEEMWRQEEKIREQEE--IWRQKEKMHE--QEKIRKQEEKVWRQEEKMHDQEEKIR 512
Query: 387 LQAQVLKLQQ---RCRMETLPGFQETL--AEELRTSLRRMISDPVYFMERNYEMPRGDTS 441
Q + + Q+ R + E + +E + EE+ + + M+ +M R +
Sbjct: 513 EQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEK 572
Query: 442 SLRYDFRYSEDREQVRG-----FEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKKVP 496
+ + E +E++R +E EE + ++M+ ++ E+ QEE K
Sbjct: 573 IREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQE----EKMWEQEE----KMCE 624
Query: 497 AEEGVMEEAELVSEETEGWEEVELEL-DEATRMNVVTSALEAS 538
EE + E+ E + + E E E+ L + +M LEA+
Sbjct: 625 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 667
Score = 50.4 bits (119), Expect = 4e-06
Identities = 71/338 (21%), Positives = 147/338 (43%), Gaps = 30/338 (8%)
Query: 202 RDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDE 261
++L + + Q+ V++N + N + E + +E+I ++ ++E ++ +
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 262 EDEDEEEEEEEKEAEEEQ----------EEEEAEEDLQCAHPCDAPKLISQEALLHQHH- 310
E E++ +EE E+E+ E+EE L+ K+ E +H+
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEK 391
Query: 311 -CPQLEALQEKLRLLEEENHQLREEA--SQLDTLEDEEQMLILECVEQFSEASQQMAELS 367
Q E QE+ ++ E+E Q +E Q + + ++E+ + EQ + +Q ++
Sbjct: 392 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI----REQEKKMWRQEEKIH 447
Query: 368 EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETL---AEELRTSLRRMISD 424
E +R E ++Q+E+ R + ++ + ++ R + QE + E++ +M
Sbjct: 448 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQ 507
Query: 425 PVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM--RGEDFTPAEE 482
E+ +M R + + + E E++R E EE + + M + E E+
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIR--EQEEMMQEQEEKMGEQEEKMQEQEK 565
Query: 483 FVPQEELGAAKKVPAEEGVMEEAELVSEETEG-WEEVE 519
QEE K EE + E+ E + E+ E WE+ E
Sbjct: 566 MRRQEE----KIREQEEKIREQKEKIREQEEKIWEQEE 599
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 55.5 bits (132), Expect = 1e-07
Identities = 78/333 (23%), Positives = 132/333 (39%), Gaps = 28/333 (8%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEE----ILYLRHQVNLRDELLQ 254
QRER L R ++ L EE K + + E L Q+ R+ Q
Sbjct: 793 QRERQLRAEER----QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 255 LYSDSDEEDEDEEEEEEEKEAEEE------QEEEEAEEDLQCAHPCDAPKLISQEALLHQ 308
L + D ED+E +++ ++ +EE + A P +L ++ LL +
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 309 HHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSE 368
+EK R E+E EE Q ++EEQ+L E ++ + ++ +
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQ----QEEEQLLREEREKRRRQERERQYRKDK 964
Query: 369 VLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYF 428
L + E ++ E R Q + K ++ E L +E L E R RR + Y
Sbjct: 965 KLQQKEEQLLGEEPEKRRRQEREKKYREE---EELQQEEEQLLREEREKRRRQEWERQY- 1020
Query: 429 MERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEE 488
+ E+ + + LR + +E+ R + EE L + + GE+ E ++E
Sbjct: 1021 -RKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE----RETRRRQE 1075
Query: 489 LGAAKKVPAEEGVMEEAELVSEETEGWEEVELE 521
L + EE EE +L+ EE E E E
Sbjct: 1076 LERQYR-KEEELQQEEEQLLREEPEKRRRQERE 1107
Score = 53.9 bits (128), Expect = 4e-07
Identities = 74/316 (23%), Positives = 122/316 (38%), Gaps = 30/316 (9%)
Query: 235 AKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPC 294
A++ +Y R + Q + E E + +EE+ A +Q+EEE D
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773
Query: 295 D-----APKLISQEALLHQHHCPQL---EALQEKLRLLEEE------NHQLREEASQLDT 340
+ + +S L + QL E Q + R L EE Q RE +L
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833
Query: 341 LEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRM 400
LE+EEQ+ E +Q E + E E R + E+++ + R Q + + ++R +
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQE----RRRSQEQRRDQKWRWQLEEERKRRRHTL 889
Query: 401 ETLPGFQETLAEELR------TSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDRE 454
P QE L +E + L+R + E+ + + + E+RE
Sbjct: 890 YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949
Query: 455 QVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGV-MEEAELVSEETE 513
+ R E E + + E+ EE + KK EE + EE +L+ EE E
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Query: 514 -----GWEEVELELDE 524
WE + DE
Sbjct: 1010 KRRRQEWERQYRKKDE 1025
Score = 53.9 bits (128), Expect = 4e-07
Identities = 73/294 (24%), Positives = 130/294 (44%), Gaps = 35/294 (11%)
Query: 242 LRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQ-----EEEEAEEDLQCAHPCDA 296
L+ Q+ +LLQ EE+E+ + EE EK +EQ EEE+ +++ + +
Sbjct: 895 LQEQLRKEQQLLQ------EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948
Query: 297 PKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEAS----QLDTLEDEEQMLILEC 352
K QE +L+ +E+L L EE + R+E + + L+ EE+ L+ E
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQL-LGEEPEKRRRQEREKKYREEEELQQEEEQLLRE- 1006
Query: 353 VEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRM----ETLPGFQE 408
E ++ + E + + +++++++ R + + +LQ+R R E L +E
Sbjct: 1007 -----EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061
Query: 409 TLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLA 468
L E R + RR + Y E E+ + + LR E+ E+ R E E
Sbjct: 1062 QLLGEERETRRRQELERQYRKEE--ELQQEEEQLLR------EEPEKRRRQERERQCREE 1113
Query: 469 ADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGV-MEEAELVSEETEGWEEVELE 521
++ + E+ EE + ++ EE V EE +L+ EE E ELE
Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Score = 52.8 bits (125), Expect = 9e-07
Identities = 74/274 (27%), Positives = 115/274 (41%), Gaps = 24/274 (8%)
Query: 261 EEDEDE--EEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQ 318
EE E++ +E + K EEEQ +E EE Q + + +E L HQ + +
Sbjct: 1323 EEREEKRRRQETDRKFREEEQLLQEREE--QPLRRQERDRKFREEELRHQEQGRKFLEEE 1380
Query: 319 EKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYE 378
++LR E E L+EE Q ++ EQ L + +F E QQ++ R E +
Sbjct: 1381 QRLRRQERERKFLKEE--QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQ 1438
Query: 379 RQQQEVARLQAQVLKLQQRCRMETLPGFQE---TLAEELRTSLRRMISDPVYFMERNYEM 435
++QE R + L+ +Q+ R E F+E L E L R D F+E ++
Sbjct: 1439 VRRQERER---KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR-KFLEEEQQL 1494
Query: 436 PRGDTSSLRYDFRYSEDREQ--VRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAK 493
R + FR E R Q R F EE + R F E+ + ++E G +
Sbjct: 1495 RRQERDR---KFREQELRSQEPERKFLEEEQQLHRQ--QRQRKFLQEEQQLRRQERGQQR 1549
Query: 494 KVPAEEGVMEEAELVSEETEGWEEVELELDEATR 527
+ + EE +L E EE +L E R
Sbjct: 1550 RQDRDRKFREEEQLRQER----EEQQLSRQERDR 1579
Score = 51.6 bits (122), Expect = 2e-06
Identities = 81/301 (26%), Positives = 125/301 (41%), Gaps = 31/301 (10%)
Query: 223 EENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEE----EEEEKEAEEE 278
E + E L +E++L + R EL + Y +EE + EEE EE EK +E
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYR-KEEELQQEEEQLLREEPEKRRRQE 1105
Query: 279 -----QEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLRE 333
+EEEE +++ + + K QE L + + + E QE+ +LL EE + R
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQE--LERQYREEEEVQQEEEQLLREEPEKRRR 1163
Query: 334 EASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLK 393
+ + E+EE E Q + E E R + ERQ +E LQ Q K
Sbjct: 1164 QELERQYREEEELQ---------QEEEQLLREEQE---KRRQERERQYREEEELQRQ--K 1209
Query: 394 LQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDR 453
+QR R E + E + + R + VY R E R S D + +D
Sbjct: 1210 RKQRYRDEDQRSDLKWQWEPEKENAVR--DNKVYCKGRENEQFRQLEDSQLRDRQSQQDL 1267
Query: 454 EQVRGFEAEEGLMLAADIMRGED-FTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEET 512
+ + G + E + D P EE + +EE AK+ + EE +L+ EE
Sbjct: 1268 QHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKR--RDRKSQEEKQLLREER 1325
Query: 513 E 513
E
Sbjct: 1326 E 1326
Score = 49.7 bits (117), Expect = 8e-06
Identities = 72/314 (22%), Positives = 121/314 (38%), Gaps = 33/314 (10%)
Query: 223 EENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEE 282
+E E S K+E L R + +EL + + E +E EEE+ + + + EE
Sbjct: 144 QERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEE 203
Query: 283 EAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEK----------LRLLEEENHQLR 332
+E+ + +E Q Q QE+ + EEE Q
Sbjct: 204 FPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE 263
Query: 333 EEASQLDTLEDEEQMLILECVE-----QFSEASQQMAELSEVLVLRLENYERQQQEVARL 387
E Q + E+EEQ+ LE E Q E QQ + L + E R+QQE R
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323
Query: 388 QAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDF 447
Q + + Q+ R + L QE E+ LRR + ER + R
Sbjct: 324 QQERREQQEERREQQLRREQEERREQ---QLRREQEE-----ERREQQLR---------- 365
Query: 448 RYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAEL 507
R E+ + + E+ L + R + ++ +++L +++ E+ + E +L
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425
Query: 508 VSEETEGWEEVELE 521
E+ E E + E
Sbjct: 426 RREQEEERHEQKHE 439
Score = 49.7 bits (117), Expect = 8e-06
Identities = 72/334 (21%), Positives = 135/334 (40%), Gaps = 27/334 (8%)
Query: 200 RERDLNTAARIGQSLVKQNSVLMEENSKL---EALLGSAKEEILYLRHQVNLRDE--LLQ 254
R+R ++ Q +Q E + K E + ++E ++ + LR + Q
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ 1612
Query: 255 LYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQL 314
L + D + ++E+ +E+E ++ +E + L+ + P+L QE H
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE-----EEPQLRRQEREQQLRHDRDR 1667
Query: 315 EALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRL 374
+ +E+ L E E QLR + E+E+Q+ E +F + QQ LR
Sbjct: 1668 KFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ---------LRR 1718
Query: 375 ENYER--QQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERN 432
+ ER +++E R + + +L+++ R + ++ E LRR D + E
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 433 YEMPRGDTS--SLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELG 490
R + S D ++ E+ EQ+R E+ L R + EE + EE
Sbjct: 1779 LRQEREEQQLRSQESDRKFREE-EQLRQEREEQQL---RPQQRDGKYRWEEEQLQLEEQE 1834
Query: 491 AAKKVPAEEGVMEEAELVSEETEGWEEVELELDE 524
+ + E + ++E EE EL +E
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRREEQELWQEE 1868
Score = 49.3 bits (116), Expect = 1e-05
Identities = 58/275 (21%), Positives = 112/275 (40%), Gaps = 29/275 (10%)
Query: 260 DEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQE 319
+EE + ++ + K +EEQ+ E Q D + +E L Q Q + QE
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ--DRDRKFREEEQLRQEREEQQLSRQE 1576
Query: 320 KLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYER 379
+ R E ++R + + +EDE+Q+ E +Q + + E L+ ER
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL-----QER 1631
Query: 380 QQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGD 439
++Q++ R + L++ ++ ++ ++LR R F E + G+
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLR-----RQEREQQLRHDRDRK------FREEEQLLQEGE 1680
Query: 440 TSSLR---YDFRYSEDREQVRGFEAEEGLMLAADIMRGED----FTPAEEFVPQEELGAA 492
LR D ++ E+ +Q+R E E + +R ++ F E+ + E
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Query: 493 KKVPAEEGVMEEAELVSEETEGWEEVELELDEATR 527
++ ++EE +L E EE +L E R
Sbjct: 1741 RRQERYRKILEEEQLRPER----EEQQLRRQERDR 1771
Score = 48.9 bits (115), Expect = 1e-05
Identities = 76/359 (21%), Positives = 135/359 (37%), Gaps = 34/359 (9%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSD 258
+R ++L R + L ++ L+ E + + E Y + R + Q Y D
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQEKRR----QERERQYREEEELQRQKRKQRYRD 1216
Query: 259 SDEEDEDEEEEEEEKE------------AEEEQ---------EEEEAEEDLQCAHPCDAP 297
D+ + + + E EKE E EQ + ++++DLQ
Sbjct: 1217 EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQE 1276
Query: 298 KLISQEALLHQH---HCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVE 354
+ QE Q H P+ E L+ + + + + +E QL E EE+ E
Sbjct: 1277 RDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336
Query: 355 QFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLK-LQQRCRMETLPGFQETLAEE 413
+F E Q + E E + R E + ++E R Q Q K L++ R+ ++ L EE
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEE 1396
Query: 414 LRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMR 473
+ + +R + S D ++ E+ +QVR E E + +R
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR 1456
Query: 474 GE---DFTPAEEFVPQEELGAAKKVPAEEGVMEEAELV--SEETEGWEEVELELDEATR 527
E F E+ + + E + + +EE + + E + E EL E R
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER 1515
Score = 47.8 bits (112), Expect = 3e-05
Identities = 64/309 (20%), Positives = 119/309 (38%), Gaps = 32/309 (10%)
Query: 216 KQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEE------ 269
+Q +EE +L + + L Q+ ++ QL D D + +EE++
Sbjct: 1371 EQGRKFLEEEQRLRRQ--ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428
Query: 270 -----EEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLL 324
EEE++ ++ E + E+ Q K +E LL + QL + + L
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488
Query: 325 EEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEV 384
EEE R+E D E+++ E +F E QQ+ + +Q+Q
Sbjct: 1489 EEEQQLRRQER---DRKFREQELRSQEPERKFLEEEQQL-------------HRQQRQRK 1532
Query: 385 ARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLR 444
+ Q L+ Q+R + ++ EE R +R + +
Sbjct: 1533 FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE 1592
Query: 445 YDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEE 504
+ ++ ED +Q+R E ++ L D ED +E +EE ++ + + EE
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQE---REEQQLHRQERDRKFLEEE 1649
Query: 505 AELVSEETE 513
+L +E E
Sbjct: 1650 PQLRRQERE 1658
Score = 47.4 bits (111), Expect = 4e-05
Identities = 69/323 (21%), Positives = 128/323 (39%), Gaps = 26/323 (8%)
Query: 214 LVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDEL------------LQLYSDSDE 261
L K+ L EE + + L +E++ L Q R+ QL +E
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312
Query: 262 EDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKL 321
E +++EE E++ EQ+EE E+ L+ QE Q + E + +
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLR----------REQEERREQQLRREQEEERREQ 362
Query: 322 RLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQ 381
+L E+ + RE+ + + EQ L E + + ++ +L LR E R++
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422
Query: 382 QEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTS 441
Q++ R Q + + +Q+ E + EE R L+R + ER + + D
Sbjct: 423 QQLRREQEEE-RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481
Query: 442 SLRYD--FRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVP-QEELGAAKKVPAE 498
R + + E+ + + E+ L + R + EE Q+ L + +++ E
Sbjct: 482 EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541
Query: 499 EGVMEEAELVSEETEGWEEVELE 521
+ E L EE + E+ E
Sbjct: 542 QEERREQLLKREEEKRLEQERRE 564
Score = 46.6 bits (109), Expect = 6e-05
Identities = 74/315 (23%), Positives = 131/315 (41%), Gaps = 50/315 (15%)
Query: 198 LQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYL--------RHQVNLR 249
L+RE+ L ++ + ++ E + E L +EE RH+ R
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 250 DELLQLYSDSDEED-------EDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQ 302
+ QL D +EE E+EE E+++ E++ E+ E Q +L Q
Sbjct: 473 KQ--QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ--------RLKRQ 522
Query: 303 EALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQ 362
E + E LQ++LR ++ + E QL E+E++ LE + ++
Sbjct: 523 E---------EEERLQQRLRSEQQLRREQEERREQLLKREEEKR---LEQERREQRLKRE 570
Query: 363 MAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMI 422
E + L+ R E ER+QQ + R Q + +L+QR + E + E L +E R R
Sbjct: 571 QEERRDQLLKREE--ERRQQRLKREQEE--RLEQRLKREEV----ERLEQEERREQRLKR 622
Query: 423 SDPVYFMERNYEMPRGDTSSLRYD---FRYSEDREQVRGFEAEEGLMLAADIMRGEDFTP 479
+P ER ++ + + R R ++R + R EE L + R +
Sbjct: 623 EEPE--EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Query: 480 AEEFVPQEELGAAKK 494
E+ + +EE A++
Sbjct: 681 REQELAEEEQEQARE 695
Score = 46.2 bits (108), Expect = 8e-05
Identities = 79/326 (24%), Positives = 127/326 (38%), Gaps = 41/326 (12%)
Query: 200 RERDLNTAARIG------QSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELL 253
R R+L R G Q +Q+ V EE K K E + + + L++E
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEK-----EWRKRETVLRKEEEKLQEEEP 265
Query: 254 QLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQ 313
Q + EE+E + E ++ E QEEE+ ++ L+ +E L + +
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR------------REQQLRRKQEEE 313
Query: 314 LEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLR 373
QE+ R +E Q E Q E EE+ EQ E +Q LR
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQ--------LR 365
Query: 374 LENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNY 433
E E ++++ R + Q+ + QQ R + L Q+ E+ LRR R
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ---QLRREQQLRREQQLRRE 422
Query: 434 EMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAK 493
+ R + R++ ++ ++R + R +E D ++ E+ T E QE
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEE---RRDWLKREEETERHE---QERRKQQL 476
Query: 494 KVPAEEGVMEEAELVSEETEGWEEVE 519
K EE E L EE E E+ E
Sbjct: 477 KRDQEE-ERRERWLKLEEEERREQQE 501
Score = 42.7 bits (99), Expect = 0.001
Identities = 73/323 (22%), Positives = 124/323 (38%), Gaps = 53/323 (16%)
Query: 223 EENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEE--------EEEEEKE 274
EE + + L +EE R Q LR E + + +E+EE E EEE+
Sbjct: 626 EEERRQQLLKSEEQEE----RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR 681
Query: 275 AEE--EQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLR 332
+E E+E+E+A E ++ P +L S EA Q QE R +E+ + R
Sbjct: 682 EQELAEEEQEQARERIKSRIPKWQWQLES-EADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 333 EEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVL 392
S+L E+E A +Q E E+++ + QA+
Sbjct: 741 RRESELQWQEEE-------------RAHRQQQE-----------EEQRRDFTWQWQAEEK 776
Query: 393 KLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSED 452
+ R R+ P +E +LR R+ E E R + ++ E+
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 453 REQVRG-------FEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAK-------KVPAE 498
EQ++ E E+GL + R ++ +++ Q E + K +
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896
Query: 499 EGVMEEAELVSEETEGWEEVELE 521
E + +E +L+ EE E + E E
Sbjct: 897 EQLRKEQQLLQEEEEELQREERE 919
Score = 40.0 bits (92), Expect = 0.006
Identities = 32/130 (24%), Positives = 59/130 (45%), Gaps = 9/130 (6%)
Query: 261 EEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEK 320
EE + +E + K EEEQ +E EE D +E L QLE +++
Sbjct: 1784 EEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL-------QLEEQEQR 1836
Query: 321 LRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQ 380
LR + ++ E+ + + EEQ L E E+ ++ +L E + R + E++
Sbjct: 1837 LRQERDRQYRAEEQFATQEKSRREEQELWQE--EEQKRRQERERKLREEHIRRQQKEEQR 1894
Query: 381 QQEVARLQAQ 390
++V +++Q
Sbjct: 1895 HRQVGEIKSQ 1904
Score = 39.3 bits (90), Expect = 0.010
Identities = 54/241 (22%), Positives = 102/241 (42%), Gaps = 20/241 (8%)
Query: 223 EENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEE 282
E + E L +E++L + R EL + Y E+EE ++EE++ E+ E+
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYR------EEEEVQQEEEQLLREEPEK 1160
Query: 283 EAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLE 342
++L+ + + +E LL + Q + QE+ R EE R++ Q
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREE---QEKRRQERERQYREEEELQRQKRKQ--RYR 1215
Query: 343 DEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMET 402
DE+Q L+ Q+ + ++V EN + +Q E ++L+ + Q + ++
Sbjct: 1216 DEDQRSDLKW--QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR----QSQQDLQH 1269
Query: 403 LPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAE 462
L G Q+ E R RR ++ R + + R S++ +Q+ E E
Sbjct: 1270 LLGEQQ---ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE 1326
Query: 463 E 463
E
Sbjct: 1327 E 1327
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 55.1 bits (131), Expect = 2e-07
Identities = 86/414 (20%), Positives = 173/414 (41%), Gaps = 90/414 (21%)
Query: 165 PVKKITQEDVKVMLYLLEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLME- 223
P+ ++T+++ + L +E L V E T + E +L R Q L+++ ++L E
Sbjct: 843 PLLQVTRQEEE--LQAKDEELLKVKEKQT-----KVEGELEEMERKHQQLLEEKNILAEQ 895
Query: 224 ---------ENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKE 274
E ++ A L + K+E+ + H + R E + +E ++ + E+++ +
Sbjct: 896 LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVE------EEEERNQILQNEKKKMQ 949
Query: 275 AEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREE 334
A + EE+ +E+ K+ ++ +++ ++E++ LLE++N + +E
Sbjct: 950 AHIQDLEEQLDEEEGARQKLQLEKVTAEA---------KIKKMEEEILLLEDQNSKFIKE 1000
Query: 335 ASQLDTLEDEEQMLILECVEQFSEASQQMAELSEV----------LVLRLENYERQQQE- 383
+ED I EC Q +E ++ L+++ L RL+ E+ +QE
Sbjct: 1001 KK---LMEDR----IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
Query: 384 -----------------VARLQAQV--LKLQQRCRMETLPGF-----QETLAEELRTSLR 419
+A LQAQ+ LKLQ + E L G ETL + +
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 420 RMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTP 479
R + + ++ ++E + + R + + E E+ L D T
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL----------DTTA 1163
Query: 480 AEEFV---PQEELGAAKKVPAEEGVMEEAELV---SEETEGWEEVELELDEATR 527
A++ + ++E+ KK EE EA++ EE+ +L++A R
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKR 1217
Score = 42.7 bits (99), Expect = 0.001
Identities = 85/400 (21%), Positives = 158/400 (39%), Gaps = 56/400 (14%)
Query: 167 KKITQEDVKVMLYLLEELLPPVW---------ESVTYGMVLQRERDLNTAARIGQS---- 213
K+ ++ V+ M LEEL + E M Q ERDL T +
Sbjct: 1534 KRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRL 1593
Query: 214 LVKQNSVL---MEENSKLEALLGSAKE----EILYLRHQVNL----RDELLQLYSDSDEE 262
L+KQ L +E+ K AL ++K+ ++ L Q+ RDE+++ +
Sbjct: 1594 LIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653
Query: 263 DEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLR 322
+D + E EE A ++ +++E + +A L QE L + A QE+
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARR-HAEQERDE 1712
Query: 323 LLEE-------------ENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELSEV 369
L +E E +L +QL+ +EEQ + ++F + + Q+ L+
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772
Query: 370 LVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRRMISDPVYFM 429
L E Q+ + AR Q + + + +++ L G ++ + ++L I +
Sbjct: 1773 LAA--ERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQ----L 1826
Query: 430 ERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEEL 489
E E + ++ R +E + +E M D R A+++ Q E
Sbjct: 1827 EEQLEQEAKERAAANKLVRRTEKK-------LKEIFMQVEDERRH-----ADQYKEQMEK 1874
Query: 490 GAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMN 529
A+ + + E E + +++ ELD+AT N
Sbjct: 1875 ANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEAN 1914
Score = 42.4 bits (98), Expect = 0.001
Identities = 79/391 (20%), Positives = 158/391 (40%), Gaps = 40/391 (10%)
Query: 201 ERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILY-LRHQVNLRDELLQLYSDS 259
+ +L+ + + + K+ ++ + LE+ L +E + R ++NL + QL +
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345
Query: 260 DEEDEDEEEEEEEKEAEEEQ----------EEEEAEEDLQCAHPCD--APKLISQEALLH 307
+ E +EEEEE ++ E+Q +++ ++DL + KL+ L
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 308 QHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMAELS 367
Q +LE LE+ ++L++E L D ++ + ++ + Q +AE
Sbjct: 1406 Q----RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK 1461
Query: 368 EVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQ--ETLAEELRTSLRRMISDP 425
+ E +R + E + + L L R E L + E ++LR + ++S
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSL-ARALEEALEAKEEFERQNKQLRADMEDLMSSK 1520
Query: 426 ------VYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADI-MRGEDFT 478
V+ +E++ +R ED +A E L ++ M+
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE-----LQATEDAKLRLEVNMQAMKAQ 1575
Query: 479 PAEEFVPQEELGAAKKVPAEEGVME-EAELVSEETEGWEEVELELDEATRMNVVTSALEA 537
+ ++E KK + V E EAEL E ++ L + +M + LEA
Sbjct: 1576 FERDLQTRDEQNEEKKRLLIKQVRELEAELEDER----KQRALAVASKKKMEIDLKDLEA 1631
Query: 538 SGLGPSHLDMNYVLQQLANWQD--AHYRRQL 566
+ ++ + V++QL Q Y+R+L
Sbjct: 1632 Q-IEAANKARDEVIKQLRKLQAQMKDYQREL 1661
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 55.1 bits (131), Expect = 2e-07
Identities = 34/89 (38%), Positives = 49/89 (55%), Gaps = 15/89 (16%)
Query: 199 QRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSD 258
+R R LN R+G S LL + + + ++ Q N ++E + D
Sbjct: 697 ERARLLNRVRRVGFS---------------HMLLTTPQVPLAPVQPQANGKEEEEEEEED 741
Query: 259 SDEEDEDEEEEEEEKEAEEEQEEEEAEED 287
+EE+EDEEEEEEE+E EEE+EEEE EE+
Sbjct: 742 EEEEEEDEEEEEEEEEEEEEEEEEEEEEE 770
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,802,838
Number of Sequences: 37866
Number of extensions: 1374969
Number of successful extensions: 47454
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 824
Number of HSP's successfully gapped in prelim test: 1055
Number of HSP's that attempted gapping in prelim test: 17379
Number of HSP's gapped (non-prelim): 12972
length of query: 594
length of database: 18,247,518
effective HSP length: 108
effective length of query: 486
effective length of database: 14,157,990
effective search space: 6880783140
effective search space used: 6880783140
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.