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Search of human proteins with 24497531
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24497531 Ellis van Creveld syndrome protein [Homo sapiens]
(992 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24497531 Ellis van Creveld syndrome protein [Homo sapiens] 1931 0.0
gi|21735548 centrosomal protein 2 [Homo sapiens] 74 7e-13
gi|16262452 cingulin [Homo sapiens] 60 8e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 60 1e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 60 1e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 60 1e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 60 1e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 60 1e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 60 1e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 60 1e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 60 1e-08
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 59 2e-08
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 55 2e-07
gi|81295809 pericentrin [Homo sapiens] 55 4e-07
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 53 2e-06
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 52 3e-06
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 52 3e-06
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 52 3e-06
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 50 1e-05
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens] 50 1e-05
gi|115511012 coiled-coil domain containing 136 [Homo sapiens] 49 2e-05
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 49 2e-05
gi|42794779 myosin 18A isoform b [Homo sapiens] 49 2e-05
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 48 4e-05
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 48 4e-05
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 48 5e-05
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 48 5e-05
gi|148746195 trichohyalin [Homo sapiens] 47 7e-05
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 47 7e-05
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 47 9e-05
>gi|24497531 Ellis van Creveld syndrome protein [Homo sapiens]
Length = 992
Score = 1931 bits (5002), Expect = 0.0
Identities = 992/992 (100%), Positives = 992/992 (100%)
Query: 1 MARGGAACKSDARLLLGRDALRPAPALLAPAVLLGAALGLGLGLWLGCRAGRQRTRHQKD 60
MARGGAACKSDARLLLGRDALRPAPALLAPAVLLGAALGLGLGLWLGCRAGRQRTRHQKD
Sbjct: 1 MARGGAACKSDARLLLGRDALRPAPALLAPAVLLGAALGLGLGLWLGCRAGRQRTRHQKD 60
Query: 61 DTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDECEPPSNSNITAFALKAKVI 120
DTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDECEPPSNSNITAFALKAKVI
Sbjct: 61 DTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDECEPPSNSNITAFALKAKVI 120
Query: 121 YPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHS 180
YPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHS
Sbjct: 121 YPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHS 180
Query: 181 ATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIF 240
ATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIF
Sbjct: 181 ATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIF 240
Query: 241 KMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVE 300
KMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVE
Sbjct: 241 KMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVE 300
Query: 301 KKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDS 360
KKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDS
Sbjct: 301 KKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDS 360
Query: 361 QELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEE 420
QELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEE
Sbjct: 361 QELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEE 420
Query: 421 LLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPT 480
LLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPT
Sbjct: 421 LLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPT 480
Query: 481 ADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFL 540
ADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFL
Sbjct: 481 ADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFL 540
Query: 541 QTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECAL 600
QTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECAL
Sbjct: 541 QTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECAL 600
Query: 601 SSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLT 660
SSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLT
Sbjct: 601 SSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLT 660
Query: 661 QMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ 720
QMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ
Sbjct: 661 QMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ 720
Query: 721 LQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVY 780
LQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVY
Sbjct: 721 LQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVY 780
Query: 781 VTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRT 840
VTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRT
Sbjct: 781 VTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRT 840
Query: 841 AGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
AGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ
Sbjct: 841 AGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
Query: 901 NFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQT 960
NFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQT
Sbjct: 901 NFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQT 960
Query: 961 SGSLSSKRLSQQESEAGDSGNSKKMLKRRSNL 992
SGSLSSKRLSQQESEAGDSGNSKKMLKRRSNL
Sbjct: 961 SGSLSSKRLSQQESEAGDSGNSKKMLKRRSNL 992
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 73.9 bits (180), Expect = 7e-13
Identities = 213/950 (22%), Positives = 398/950 (41%), Gaps = 169/950 (17%)
Query: 138 SLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHSATSDDRFLSRTFLRVNA 197
+L E L+ + L + + + +L++ E+ SSS ++ ++ L ++++A
Sbjct: 544 TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603
Query: 198 FPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDEL 257
E LA + V ++ + L ++ E+ +Q+ DL +K + L
Sbjct: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV------DLAEAEKRREAL 657
Query: 258 YQKI------LSKQE----------KDLEELEKGLQVKLSNTE-MSGAGDSEYITLADVE 300
++K L K E +D++E ++ +Q KLS + A ++ L
Sbjct: 658 WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA 717
Query: 301 KKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDS 360
K++ E + + EA ++ A ++ L + A QL L+ E L ++
Sbjct: 718 KRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQ-GLSSAKELLESSLFEA 776
Query: 361 QELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEE 420
Q+ ++ +E T G+ L++Q+Q T+ + E++ GE + K E
Sbjct: 777 QQQNSV--IEVTKGQ---------LEVQIQTVTQAK--------EVIQGEVRCL---KLE 814
Query: 421 LLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQE--EEQRSF----L 474
L T++ +A QE + +R+ Q ++ TA + ++ +E E++RS+ L
Sbjct: 815 LDTERSQAE-QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQEL 873
Query: 475 AEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKF 534
A+A + + EK +E + E+Q M+ + E R T+A ALCQ ++T ++
Sbjct: 874 AKALESLEREK-MELEMRLKEQQTEMEAIQAQREEER-TQAESALCQ----MQLETEKER 927
Query: 535 VDAL--FLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQ 592
V L LQT + ++ + LRQ+++ + + + Q + +EL E +Q
Sbjct: 928 VSLLETLLQTQKELADAS-QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQ 986
Query: 593 VWMEECAL----SSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSA--- 645
+ AL SS+LQ + D + + + +L ++S R V Q LR
Sbjct: 987 HRDDLAALQEESSSLLQDKM--DLQKQVEDLKSQLVA-QDDSQRLVEQEVQEKLRETQEY 1043
Query: 646 --LRRLALRGNALATLTQMRLSGKKHLLQE---LREQR--ALEQGSSQCLDEH-----QW 693
+++ R A TL+ M + +LQE +R+Q AL Q + E Q
Sbjct: 1044 NRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM 1103
Query: 694 QLLR-----------ALEARVLEE------------ASRLEEEAQQTRLQLQQR------ 724
+LLR A EA++LEE AS +EA+ +LQL+ R
Sbjct: 1104 ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQL 1163
Query: 725 -LLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAK--------------------D 763
LA Q+ G Q + A + L A + +SR +
Sbjct: 1164 EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA 1223
Query: 764 RDDFKRTLMEAAVESVYVTSAGVSRLVQAYY--QQIGRIMEDHEERKLQHLKTLQGERME 821
R FKR + A+ + V SA + +L Q + QQ ++ D ++ + L + E+ +
Sbjct: 1224 RSLFKRGPLLTALSAEAVASA-LHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ 1282
Query: 822 NYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQA 881
+ + Q+L S ++ E Q + L + +A Q RL + Q
Sbjct: 1283 VHT--ELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASL----QSRLRRAELQR 1336
Query: 882 GVMDLLEAQLETQL-QEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTKR----- 935
+EAQ E +L Q A++N +++ L + + E++ + G+LE+ LRT R
Sbjct: 1337 -----MEAQGERELLQAAKENLTAQVEHL-QAAVVEARAQASAAGILEEDLRTARSALKL 1390
Query: 936 ----------KKPLPQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQESE 975
+ QE+G+L V + L Q + +L ++ L+++E E
Sbjct: 1391 KNEEVESERERAQALQEQGELKVAQGKAL----QENLALLTQTLAEREEE 1436
Score = 58.2 bits (139), Expect = 4e-08
Identities = 192/918 (20%), Positives = 368/918 (40%), Gaps = 129/918 (14%)
Query: 54 RTRHQKDDTQNLLKNLESNAQTPSETGSPSRRRKREVQMSK-DKEAVDECEPPSNSNITA 112
+ + +K + +LES ET + + R R ++ + + + E + N+TA
Sbjct: 1296 QNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTA 1355
Query: 113 FA--LKAKVIYPINQKFRPLADGSSNPSLHENLKQA----VLPHQPVEASPSSSLGSLSQ 166
L+A V+ A S+ L E+L+ A L ++ VE+ + Q
Sbjct: 1356 QVEHLQAAVV-------EARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQ 1408
Query: 167 GEKDDCSSSSSVHSATSDDRFLSRTFLRVNAFPEVLACESVDVD---------LCIYSLH 217
GE + + L++T E L + +++ L + SL
Sbjct: 1409 GELKVAQGKALQENLA----LLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464
Query: 218 LKDLLHLDTALRQEKHMMFIQIFKMC--LLDLLPKKKSDDELYQKILSKQEKDLEELEKG 275
LK + + L+QE+ IQ + C +L+ LP + E QK L+ Q + + ELEK
Sbjct: 1465 LKKR-NQEVDLQQEQ----IQELEKCRSVLEHLPMAVQERE--QK-LTVQREQIRELEKD 1516
Query: 276 LQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVD----- 330
+ + + E L ++EKK++ Q ++ KQ+ ++ ++
Sbjct: 1517 RETQRNVLEHQ---------LLELEKKDQMIESQR-GQVQDLKKQLVTLECLALELEENH 1566
Query: 331 -QFKCSSSKARQLMMTLTERMIAAEGLLCD----SQELQALDALERTMGRAHMAKVIEFL 385
+ +C ++L + +A L D SQELQA + + +H + L
Sbjct: 1567 HKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL-ESHSTVLAREL 1625
Query: 386 KLQVQE--ETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQR 443
+ + QE R ++ + E L + + R+ +EL+ Q+ + E +R +R+
Sbjct: 1626 QERDQEVKSQREQIEELQRQKEHLTQDLE---RRDQELMLQKERIQVLEDQR-TRQTKIL 1681
Query: 444 GKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCD 503
+DL L+ + G T Q ++R A+ P K A LE +L+ D
Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQER-----AEEGKGPSK---AQRGSLEHMKLILRD 1733
Query: 504 LEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGL----PPEECDYLRQ 559
E+E V + + QEL D ++ + L + G T L +E L+Q
Sbjct: 1734 KEKE--VECQQEHIHELQELK----DQLEQQLQGLHRKV--GETSLLLSQREQEIVVLQQ 1785
Query: 560 EVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVW-MEECALSSVLQTHLREDHEGTIRG 618
++QE K + Q + + L ++DQ++ +++ + Q ++ ++G
Sbjct: 1786 QLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQG 1845
Query: 619 VLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQR 678
L + +T + LQ H R LA+ G + L ++ + ++ +
Sbjct: 1846 ALEQ-AHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL 1904
Query: 679 ALEQGSSQCLDEHQ---------WQLLRA--------LEA-RVLEEASRLEEEAQQTRLQ 720
AL+Q ++ EH+ W +A LEA R ++SR +EEA + R +
Sbjct: 1905 ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAE 1964
Query: 721 LQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRD---DFKRTLMEA--- 774
Q L +A Q +QH+ + QA L + A+T + D R L EA
Sbjct: 1965 ALQEALGKAHAALQGKEQHL---LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI 2021
Query: 775 ----AVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQE 830
+ V +L QA Q+ + H++ + Q L+ +R++ +++KQ
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELR--HQQEREQLLEKSLAQRVQENMIQEKQN 2079
Query: 831 LSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHA---------QQQQA 881
L G H++ + + + +++ L Q+ L A ++Q+
Sbjct: 2080 LGQERE-EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQS 2138
Query: 882 GVMDLLEAQLETQLQEAE 899
+D LE +L+ +L+ +
Sbjct: 2139 LKLDSLEPRLQRELERLQ 2156
Score = 57.0 bits (136), Expect = 9e-08
Identities = 181/817 (22%), Positives = 309/817 (37%), Gaps = 140/817 (17%)
Query: 252 KSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLI 311
+ + EL Q +E L+ + + +G + + T K + E E
Sbjct: 1340 QGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESER 1399
Query: 312 DNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQ------- 364
+ +A +Q V Q K L TL ER E L QEL+
Sbjct: 1400 ERAQALQEQ----GELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQK 1455
Query: 365 -ALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLT 423
AL+ L + + + ++ + Q+QE +CR LE L ++ +++E+ LT
Sbjct: 1456 AALELLSLDLKKRNQE--VDLQQEQIQELEKCRSV-----LEHLP----MAVQEREQKLT 1504
Query: 424 QQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADP 483
Q + + +++ ++ L HQ+ L E++ + ++ D
Sbjct: 1505 VQREQIRE---------LEKDRETQRNVLEHQL-------LELEKKDQMIESQRGQVQDL 1548
Query: 484 EKFLEAFH----EVLERQRLMQCD---LEEEENVRATEAVVALCQELYFSTVDTFQKFVD 536
+K L E+ E M+C ++E E R T+ V L T+D ++ +
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVA-----LTHLTLDLEERSQE 1603
Query: 537 ALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR-----FRRQQWKLFQELLEQDQ 591
LQ L +E+QE Q KS R +RQ+ L Q+L +DQ
Sbjct: 1604 ---LQAQSSQIHDLESHSTVLARELQERD--QEVKSQREQIEELQRQKEHLTQDLERRDQ 1658
Query: 592 QVWMEECALSSV-----LQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQ-------GHD 639
++ +++ + + QT + E+ I+ L R G + R ++Q G
Sbjct: 1659 ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL-RERGRELTTQRQLMQERAEEGKGPS 1717
Query: 640 LLLRSALR--RLALRGNALATLTQMRLSGKKHLLQELREQRALEQ---------GSSQCL 688
R +L +L LR Q H LQEL++Q LEQ G + L
Sbjct: 1718 KAQRGSLEHMKLILRDKEKEVECQQE---HIHELQELKDQ--LEQQLQGLHRKVGETSLL 1772
Query: 689 DEHQWQLLRALEARVLE--EASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQ 746
+ Q + L+ ++ E E L+E++ Q++L QR LA+ + + LQQ + A GQ
Sbjct: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQ 1832
Query: 747 ALLVHARNAAT-----------KSRAKDRDDFK----RTLMEAAVESVYVT--------- 782
V + A K R + D K R E AVE V
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892
Query: 783 ---SAGVSRLVQAYYQQIGRIMEDHE--ERKLQHL------------KTLQGERMENYKL 825
S + + A QQ ++HE R LQ + L+ R E+
Sbjct: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSS 1952
Query: 826 RKKQELSNPSSGS--RTAGGAHETSQAVHQRMLSQQK--RFLAQFPVHQQMRLHAQQQQA 881
R ++E + + + G AH Q Q +L Q + R L Q L A Q +
Sbjct: 1953 RHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHS 2012
Query: 882 GVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLL---PAKRGLLEKPLRTKRKKP 938
++ E ++Q+ + + ++ L + + L + LLEK L + ++
Sbjct: 2013 RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN 2072
Query: 939 LPQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQESE 975
+ QE+ +LG E+ G S L+Q+E E
Sbjct: 2073 MIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQE 2109
Score = 42.0 bits (97), Expect = 0.003
Identities = 141/579 (24%), Positives = 229/579 (39%), Gaps = 85/579 (14%)
Query: 405 ELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTL 464
EL+ E LS +EE L+ Q Q + ++ V+ G ++ S H+
Sbjct: 322 ELMEHEASLSRNAQEEKLSLQ-----QVIKDITQVMVEEGDNIAQGS-GHE--------- 366
Query: 465 AQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELY 524
E S + D +K L VL R+R DL ++ + + V L Q+ +
Sbjct: 367 -NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQ--LAGCQEAVNLLQQQH 423
Query: 525 FSTVDT-------FQKFV---DALFLQT--LPGMTGLPPEECDYLRQ---------EVQE 563
+ QK D L QT L G +E + L++ EV E
Sbjct: 424 DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483
Query: 564 NAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLRE---DHEGTIRGVL 620
AW+L + N + Q Q E+ Q EE L+ + L+E E L
Sbjct: 484 QEAWRLRRVNVELQLQGDSAQGQKEEQQ----EELHLAVRERERLQEMLMGLEAKQSESL 539
Query: 621 GRLGGLTEESTRCVLQGHDLL-----LRSALRR-------LALRGNALAT-LTQMRLSGK 667
L L E L+G L + +AL R L+ N L T + +R +
Sbjct: 540 SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAV 599
Query: 668 KHLLQELREQRALEQ-GSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLL 726
K L L E AL++ G +Q QLL+ LE SR+E A+Q R LQ L
Sbjct: 600 K--LSALNEALALDKVGLNQ-------QLLQ-LEEENQSVCSRMEA-AEQARNALQVDL- 647
Query: 727 AEAQEVGQLLQQ---HMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTS 783
AEA++ + L + H+E + +A A ++ +D + K + + ES +
Sbjct: 648 AEAEKRREALWEKNTHLEAQLQKA---EEAGAELQADLRDIQEEKEEIQKKLSESRHQQE 704
Query: 784 AGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERME-NYKL----RKKQELSNPSSGS 838
A ++L Q + Q + E+ R +Q + L E+ +L R +Q+L+ G
Sbjct: 705 AATTQLEQLH--QEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Query: 839 RTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEA 898
+A E+S Q+ S + Q V Q A++ G + L+ +L+T+ +A
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA 822
Query: 899 EQNFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKK 937
EQ + LA+ L ++ EK + R+K
Sbjct: 823 EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREK 861
Score = 38.9 bits (89), Expect = 0.024
Identities = 129/618 (20%), Positives = 230/618 (37%), Gaps = 123/618 (19%)
Query: 247 LLPKKKSDDELYQKILSKQEKDLEELEK---GLQVKLSNTEMS-GAGDSEYITLADVEKK 302
+L K+ + E Q+ + + ++ ++LE+ GL K+ T + + E + L ++
Sbjct: 1730 ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE 1789
Query: 303 EREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQE 362
RE E ++++ +D+ + + ++ Q + L + A+G + +
Sbjct: 1790 AREQGELKEQSLQS-----------QLDEAQRALAQRDQELEALQQEQQQAQGQ--EERV 1836
Query: 363 LQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLA---AIS----HGLELLAGEGKLSG 415
+ DAL+ + +AHM +LQ +E RL A+ LE + G+ +
Sbjct: 1837 KEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES 1896
Query: 416 RQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLA 475
R++E+ L + ++A+ E + +D + A E +L + E Q S
Sbjct: 1897 REQEKALLALQQQCAEQAQEHEVE-TRALQDSWLQAQAVLKERDQELEALRAESQSSRHQ 1955
Query: 476 EAQPTADPEKFLEAF---HEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQ 532
E A E EA H L+ + Q LE+ E R+ EA A Q + +
Sbjct: 1956 EEAARARAEALQEALGKAHAALQGKE--QHLLEQAELSRSLEASTATLQASLDACQAHSR 2013
Query: 533 KFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQ 592
+ +AL +Q G ++ +++VQ+ + R QQ + ++LLE+
Sbjct: 2014 QLEEALRIQE-----GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQER--EQLLEKSLA 2066
Query: 593 VWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALR 652
++E + Q +E E IRG L ++R L
Sbjct: 2067 QRVQENMIQEK-QNLGQEREEEEIRG-----------------------LHQSVREL--- 2099
Query: 653 GNALATLTQMRLSGKKHLLQELREQR------ALEQGSSQCLDEHQWQLLRALEARVLEE 706
Q+ L+ K+ + ELRE + AL E Q L +LE R+ E
Sbjct: 2100 --------QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRE 2151
Query: 707 ASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
RL+ +QT AR + +A+D
Sbjct: 2152 LERLQAALRQTE---------------------------------AREIEWREKAQD--- 2175
Query: 767 FKRTLMEAAVESVYVTSAGVSRLVQ-AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKL 825
S+ T A VS L + A + Q + D E+++LQ L +E +L
Sbjct: 2176 --------LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERL 2227
Query: 826 RKKQELSNPSSGSRTAGG 843
S GSR G
Sbjct: 2228 HSPGATSTAELGSRGEQG 2245
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 60.5 bits (145), Expect = 8e-09
Identities = 160/698 (22%), Positives = 291/698 (41%), Gaps = 122/698 (17%)
Query: 250 KKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQ 309
++K D+E+ K+ + LE + GL+ +L E S L + K E + S +
Sbjct: 372 QRKLDEEV------KKRQKLEPSQVGLERQL---EEKTEECSRLQELLERRKGEAQQSNK 422
Query: 310 LIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDAL 369
+ NM+ Q +++H L Q +M L ++ +G ++E+ D L
Sbjct: 423 ELQNMKRLLDQGEDLRHGLETQ-----------VMELQNKLKHVQGPE-PAKEVLLKDLL 470
Query: 370 ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAF 429
E R + +V+E K +V+E+ R R ++ L G KEE+ ++ +
Sbjct: 471 ET---RELLEEVLEG-KQRVEEQLRLRERELT----------ALKGALKEEVASRDQEVE 516
Query: 430 WQEAERFSREFVQRGKDLVTASLAHQV--EGTAKLTLAQEEEQRSFLAEAQPTADPEKFL 487
+++ R+ Q + + A+ H V K++ QR ++ T +
Sbjct: 517 -HVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMF 575
Query: 488 EAFHEVLE--RQRLMQCDLEEEE-NVRATEAVVALCQELY---FSTVDTFQKFVDALFLQ 541
+ E L +Q L+Q +E+EE E + L +EL S DT Q V+ L +
Sbjct: 576 QKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQ--VEVLKKE 633
Query: 542 TLPGMTGLPPEECDYLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECAL 600
L L + + QEV + +L K R + +EL EQ+ Q L
Sbjct: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQ-------L 686
Query: 601 SSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLT 660
LQ LR+D E + + E+ VL + + LR +
Sbjct: 687 QKTLQ-QLRQDCEEASKAKM------VAEAEATVLGQRRAAVETTLRETQEENDEF---- 735
Query: 661 QMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ 720
+ R+ G L Q+L+E R L G A+EAR+ ++ RLE E Q Q
Sbjct: 736 RRRILG---LEQQLKETRGLVDGGE------------AVEARLRDKLQRLEAEKQ----Q 776
Query: 721 LQQRLLAEAQEVGQL--LQQHMECAIGQALLVHAR---NAATKSRAKDRDDFKRTLMEAA 775
L++ L A +E G L ++ +E + +A AR T +RA + + +R ++
Sbjct: 777 LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRG 836
Query: 776 VESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSN-- 833
+ + R V +++ +I ED + Q L+ LQ + +E+YK + ++E+++
Sbjct: 837 KAELEEQKRLLDRTVDRLNKELEKIGEDSK----QALQQLQAQ-LEDYKEKARREVADAQ 891
Query: 834 ------PSSGSRTAGG-------------AHETSQA------VHQRMLSQQKRFLAQFPV 868
S +T+GG A + SQA + + +L+Q+ + L Q
Sbjct: 892 RQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAE 951
Query: 869 HQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISEL 906
+++ + +Q ++ ++LET+L E E+N + L
Sbjct: 952 NKKRSQDDRARQLKGLEEKVSRLETELDE-EKNTVELL 988
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 59.7 bits (143), Expect = 1e-08
Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)
Query: 291 SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
S+YI TL +E++ER +Q + E ++A ++ L Q + + +
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 338 --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
+A++L + E ++ E D+Q ELQ L + +A A+ E
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446
Query: 386 KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
+L+++EE R RL + + EG+L R + E Q + +EAER R+
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 444 G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
K LA +V+ A+ A E+QR+ A + E+ + +ER R +
Sbjct: 1507 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563
Query: 501 QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
Q LE + R+ EA + + + ++ V L+ E +
Sbjct: 1564 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1621
Query: 556 YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
R+E + E WQL K+N R + + +E+ +Q E + R +
Sbjct: 1622 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 615 TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
+ V R L E R + +G +A +RLA L T+ ++ L
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Query: 672 QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
+EL + ++Q E + +L +RA +L +R EEE++ T + +QRL AEA
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793
Query: 730 QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
+L + E A +AL A R A + A+ R + +R L E AA+ T
Sbjct: 1794 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850
Query: 783 SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
A ++ + +A +++ R+ ED EE+ QH ++ ER+ + EL
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1906
Query: 835 SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
R G +T + V + +L+ + F ++ L + ++ D L ++
Sbjct: 1907 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 892 ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
+ +L+ A Q +LAA + + AE + ++ LE+ R K K
Sbjct: 1964 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2017
Query: 940 PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
+E L ++ A Q + + KRL +E
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Score = 54.3 bits (129), Expect = 6e-07
Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)
Query: 336 SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
+ K QL +L E +A L + E +A E R + +E +L+ E R
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
RL A E +A + L+ + E+ Q + +EA R + E R ++L L
Sbjct: 1645 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 454 HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
Q EGTA+ LA E+E AE + + LE L+R+ +E
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 508 --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
VRA V+ A +E ST + ++ ++A F + L EE
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815
Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
RQ +E+AA Q ++ R ++ E L+ + ++ ++E + L ED
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 612 -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
H+ I L +L GL E++ R Q ++L A
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 649 LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
A G A L R+ +EQ LE + L + + R E RV + +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 709 RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
EE A+Q + L++ RL A+ +E +L ++ + + Q L
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2040
Query: 767 FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
EAA + + + VQ +E++LQ +TLQ E+ +LR
Sbjct: 2041 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2080
Query: 827 KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
+ E +R A E ++ +R +Q +R + + +Q Q +A
Sbjct: 2081 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 887 LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
E + QEA + +E AAL + A++++ K+ E+ LR K
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2181
Score = 52.0 bits (123), Expect = 3e-06
Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)
Query: 231 EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
EKH F + L K + + EL L +E D ++ L++ LQ +K TE +
Sbjct: 2168 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2221
Query: 288 AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
L V + E S+ +N + N Q FL ++ + K +Q+
Sbjct: 2222 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2277
Query: 344 MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
+AA+ ++ L+ L + RA K+++ VQE TR + A
Sbjct: 2278 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2329
Query: 404 LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
ELL QQ + ++A R +Q K+ + LA + +G +
Sbjct: 2330 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2368
Query: 464 LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
A+ + Q AEA ER +L ++ EE+ R +
Sbjct: 2369 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411
Query: 518 ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
+ ++L+ + + T +K +QTL + + LR+ + E L + +
Sbjct: 2412 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2463
Query: 578 QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
Q+ KL Q E+ Q V E+ L+E T+ + L
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2498
Query: 638 HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
D LL+ R + L L Q ++ + L +E R+Q+ +EQ + + +
Sbjct: 2499 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 697 RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
R EA E R +EE QQ Q +Q+ LLAE +E QLL++ A+ + V
Sbjct: 2558 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Query: 751 HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
A AATK+ RD EA E + G+ R V A Q I+ E ++L
Sbjct: 2616 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2672
Score = 48.9 bits (115), Expect = 2e-05
Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
+D +K+S E Q++ E +++ K Q + + + + +E ER
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 305 EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
+ + EA +Q L Q + S + RQ + L R+ A AE
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 355 GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
+ LQAL+ L E R A+V ++QV ET R A EL +
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1582
Query: 411 GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
+ + Q E L ++H A Q EAER +++ + R ++ L Q++ L
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 463 TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
L A+E Q+ LA+A+ E EA E E Q + Q +L E+E + +
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 515 AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
Q+ + + + L +T G E + R + + AA Q +
Sbjct: 1700 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 575 FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
+ + E+L + EE +S E G R + RL L EE+
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 632 RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
R L D + A +LA G A L T ++ L K+ + LR
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 676 -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
++R LE+ ++Q ++E QL +A ++ LE L E+ + R Q+++ +LA +
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 730 QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
E + +E +G+ NA R+K++ + +EAA + R
Sbjct: 1934 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1984
Query: 790 VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
Q E+ R+ L+ ++ L+ + E +LR++ E +A
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2037
Query: 846 ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
+A +R+ +++K +Q QQ+ V+D L + E + AE+
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Score = 33.5 bits (75), Expect = 1.0
Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
++ L K K+ E + L ++KD EE EK QV +S A +
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 295 TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
D+ ++ + L + M+A + ++ L Q + + +AR+L ++
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2353
Query: 353 AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
A+ L ++Q Q ER + M+ E LKL+V E +R + A +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 413 LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
+ + + EL TQ+ Q E ER + Q K L
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 451 SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
S Q +L + Q+SFL+E E+F+E A E L + + + E
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 508 ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
E R + + Q L S + ++ +A EE L Q+ ++
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2585
Query: 568 QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
L + N+ R+Q +L +E L ++V + A + L +
Sbjct: 2586 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645
Query: 612 HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
+G R V L G L+ E + + QGH D L R R L+G + ++
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2705
Query: 665 SGKKHLLQELREQRALEQGSSQCLDEHQ 692
+ +K + +++ L G++ L E Q
Sbjct: 2706 TNEKLSVYAALQRQLLSPGTALILLEAQ 2733
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 59.7 bits (143), Expect = 1e-08
Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)
Query: 291 SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
S+YI TL +E++ER +Q + E ++A ++ L Q + + +
Sbjct: 1335 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1390
Query: 338 --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
+A++L + E ++ E D+Q ELQ L + +A A+ E
Sbjct: 1391 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1450
Query: 386 KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
+L+++EE R RL + + EG+L R + E Q + +EAER R+
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510
Query: 444 G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
K LA +V+ A+ A E+QR+ A + E+ + +ER R +
Sbjct: 1511 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1567
Query: 501 QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
Q LE + R+ EA + + + ++ V L+ E +
Sbjct: 1568 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1625
Query: 556 YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
R+E + E WQL K+N R + + +E+ +Q E + R +
Sbjct: 1626 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1683
Query: 615 TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
+ V R L E R + +G +A +RLA L T+ ++ L
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1737
Query: 672 QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
+EL + ++Q E + +L +RA +L +R EEE++ T + +QRL AEA
Sbjct: 1738 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1797
Query: 730 QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
+L + E A +AL A R A + A+ R + +R L E AA+ T
Sbjct: 1798 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1854
Query: 783 SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
A ++ + +A +++ R+ ED EE+ QH ++ ER+ + EL
Sbjct: 1855 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1910
Query: 835 SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
R G +T + V + +L+ + F ++ L + ++ D L ++
Sbjct: 1911 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967
Query: 892 ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
+ +L+ A Q +LAA + + AE + ++ LE+ R K K
Sbjct: 1968 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2021
Query: 940 PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
+E L ++ A Q + + KRL +E
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055
Score = 54.3 bits (129), Expect = 6e-07
Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)
Query: 336 SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
+ K QL +L E +A L + E +A E R + +E +L+ E R
Sbjct: 1590 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1648
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
RL A E +A + L+ + E+ Q + +EA R + E R ++L L
Sbjct: 1649 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1699
Query: 454 HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
Q EGTA+ LA E+E AE + + LE L+R+ +E
Sbjct: 1700 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1759
Query: 508 --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
VRA V+ A +E ST + ++ ++A F + L EE
Sbjct: 1760 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1819
Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
RQ +E+AA Q ++ R ++ E L+ + ++ ++E + L ED
Sbjct: 1820 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879
Query: 612 -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
H+ I L +L GL E++ R Q ++L A
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939
Query: 649 LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
A G A L R+ +EQ LE + L + + R E RV + +
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999
Query: 709 RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
EE A+Q + L++ RL A+ +E +L ++ + + Q L
Sbjct: 2000 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2044
Query: 767 FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
EAA + + + VQ +E++LQ +TLQ E+ +LR
Sbjct: 2045 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2084
Query: 827 KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
+ E +R A E ++ +R +Q +R + + +Q Q +A
Sbjct: 2085 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2138
Query: 887 LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
E + QEA + +E AAL + A++++ K+ E+ LR K
Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2185
Score = 52.0 bits (123), Expect = 3e-06
Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)
Query: 231 EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
EKH F + L K + + EL L +E D ++ L++ LQ +K TE +
Sbjct: 2172 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2225
Query: 288 AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
L V + E S+ +N + N Q FL ++ + K +Q+
Sbjct: 2226 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2281
Query: 344 MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
+AA+ ++ L+ L + RA K+++ VQE TR + A
Sbjct: 2282 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2333
Query: 404 LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
ELL QQ + ++A R +Q K+ + LA + +G +
Sbjct: 2334 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2372
Query: 464 LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
A+ + Q AEA ER +L ++ EE+ R +
Sbjct: 2373 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2415
Query: 518 ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
+ ++L+ + + T +K +QTL + + LR+ + E L + +
Sbjct: 2416 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2467
Query: 578 QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
Q+ KL Q E+ Q V E+ L+E T+ + L
Sbjct: 2468 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2502
Query: 638 HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
D LL+ R + L L Q ++ + L +E R+Q+ +EQ + + +
Sbjct: 2503 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561
Query: 697 RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
R EA E R +EE QQ Q +Q+ LLAE +E QLL++ A+ + V
Sbjct: 2562 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619
Query: 751 HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
A AATK+ RD EA E + G+ R V A Q I+ E ++L
Sbjct: 2620 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2676
Score = 48.9 bits (115), Expect = 2e-05
Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
+D +K+S E Q++ E +++ K Q + + + + +E ER
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1470
Query: 305 EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
+ + EA +Q L Q + S + RQ + L R+ A AE
Sbjct: 1471 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530
Query: 355 GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
+ LQAL+ L E R A+V ++QV ET R A EL +
Sbjct: 1531 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1586
Query: 411 GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
+ + Q E L ++H A Q EAER +++ + R ++ L Q++ L
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646
Query: 463 TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
L A+E Q+ LA+A+ E EA E E Q + Q +L E+E + +
Sbjct: 1647 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703
Query: 515 AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
Q+ + + + L +T G E + R + + AA Q +
Sbjct: 1704 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1758
Query: 575 FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
+ + E+L + EE +S E G R + RL L EE+
Sbjct: 1759 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 632 RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
R L D + A +LA G A L T ++ L K+ + LR
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 676 -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
++R LE+ ++Q ++E QL +A ++ LE L E+ + R Q+++ +LA +
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1937
Query: 730 QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
E + +E +G+ NA R+K++ + +EAA + R
Sbjct: 1938 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1988
Query: 790 VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
Q E+ R+ L+ ++ L+ + E +LR++ E +A
Sbjct: 1989 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2041
Query: 846 ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
+A +R+ +++K +Q QQ+ V+D L + E + AE+
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096
Score = 33.5 bits (75), Expect = 1.0
Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
++ L K K+ E + L ++KD EE EK QV +S A +
Sbjct: 2241 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2300
Query: 295 TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
D+ ++ + L + M+A + ++ L Q + + +AR+L ++
Sbjct: 2301 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2357
Query: 353 AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
A+ L ++Q Q ER + M+ E LKL+V E +R + A +
Sbjct: 2358 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2416
Query: 413 LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
+ + + EL TQ+ Q E ER + Q K L
Sbjct: 2417 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476
Query: 451 SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
S Q +L + Q+SFL+E E+F+E A E L + + + E
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536
Query: 508 ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
E R + + Q L S + ++ +A EE L Q+ ++
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2589
Query: 568 QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
L + N+ R+Q +L +E L ++V + A + L +
Sbjct: 2590 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2649
Query: 612 HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
+G R V L G L+ E + + QGH D L R R L+G + ++
Sbjct: 2650 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2709
Query: 665 SGKKHLLQELREQRALEQGSSQCLDEHQ 692
+ +K + +++ L G++ L E Q
Sbjct: 2710 TNEKLSVYAALQRQLLSPGTALILLEAQ 2737
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 59.7 bits (143), Expect = 1e-08
Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)
Query: 291 SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
S+YI TL +E++ER +Q + E ++A ++ L Q + + +
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 338 --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
+A++L + E ++ E D+Q ELQ L + +A A+ E
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446
Query: 386 KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
+L+++EE R RL + + EG+L R + E Q + +EAER R+
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 444 G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
K LA +V+ A+ A E+QR+ A + E+ + +ER R +
Sbjct: 1507 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563
Query: 501 QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
Q LE + R+ EA + + + ++ V L+ E +
Sbjct: 1564 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1621
Query: 556 YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
R+E + E WQL K+N R + + +E+ +Q E + R +
Sbjct: 1622 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 615 TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
+ V R L E R + +G +A +RLA L T+ ++ L
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Query: 672 QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
+EL + ++Q E + +L +RA +L +R EEE++ T + +QRL AEA
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793
Query: 730 QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
+L + E A +AL A R A + A+ R + +R L E AA+ T
Sbjct: 1794 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850
Query: 783 SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
A ++ + +A +++ R+ ED EE+ QH ++ ER+ + EL
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1906
Query: 835 SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
R G +T + V + +L+ + F ++ L + ++ D L ++
Sbjct: 1907 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 892 ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
+ +L+ A Q +LAA + + AE + ++ LE+ R K K
Sbjct: 1964 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2017
Query: 940 PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
+E L ++ A Q + + KRL +E
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Score = 54.3 bits (129), Expect = 6e-07
Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)
Query: 336 SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
+ K QL +L E +A L + E +A E R + +E +L+ E R
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
RL A E +A + L+ + E+ Q + +EA R + E R ++L L
Sbjct: 1645 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 454 HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
Q EGTA+ LA E+E AE + + LE L+R+ +E
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 508 --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
VRA V+ A +E ST + ++ ++A F + L EE
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815
Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
RQ +E+AA Q ++ R ++ E L+ + ++ ++E + L ED
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 612 -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
H+ I L +L GL E++ R Q ++L A
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 649 LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
A G A L R+ +EQ LE + L + + R E RV + +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 709 RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
EE A+Q + L++ RL A+ +E +L ++ + + Q L
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2040
Query: 767 FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
EAA + + + VQ +E++LQ +TLQ E+ +LR
Sbjct: 2041 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2080
Query: 827 KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
+ E +R A E ++ +R +Q +R + + +Q Q +A
Sbjct: 2081 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 887 LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
E + QEA + +E AAL + A++++ K+ E+ LR K
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2181
Score = 52.0 bits (123), Expect = 3e-06
Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)
Query: 231 EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
EKH F + L K + + EL L +E D ++ L++ LQ +K TE +
Sbjct: 2168 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2221
Query: 288 AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
L V + E S+ +N + N Q FL ++ + K +Q+
Sbjct: 2222 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2277
Query: 344 MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
+AA+ ++ L+ L + RA K+++ VQE TR + A
Sbjct: 2278 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2329
Query: 404 LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
ELL QQ + ++A R +Q K+ + LA + +G +
Sbjct: 2330 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2368
Query: 464 LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
A+ + Q AEA ER +L ++ EE+ R +
Sbjct: 2369 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411
Query: 518 ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
+ ++L+ + + T +K +QTL + + LR+ + E L + +
Sbjct: 2412 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2463
Query: 578 QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
Q+ KL Q E+ Q V E+ L+E T+ + L
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2498
Query: 638 HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
D LL+ R + L L Q ++ + L +E R+Q+ +EQ + + +
Sbjct: 2499 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 697 RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
R EA E R +EE QQ Q +Q+ LLAE +E QLL++ A+ + V
Sbjct: 2558 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Query: 751 HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
A AATK+ RD EA E + G+ R V A Q I+ E ++L
Sbjct: 2616 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2672
Score = 48.9 bits (115), Expect = 2e-05
Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
+D +K+S E Q++ E +++ K Q + + + + +E ER
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 305 EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
+ + EA +Q L Q + S + RQ + L R+ A AE
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 355 GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
+ LQAL+ L E R A+V ++QV ET R A EL +
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1582
Query: 411 GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
+ + Q E L ++H A Q EAER +++ + R ++ L Q++ L
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 463 TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
L A+E Q+ LA+A+ E EA E E Q + Q +L E+E + +
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 515 AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
Q+ + + + L +T G E + R + + AA Q +
Sbjct: 1700 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 575 FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
+ + E+L + EE +S E G R + RL L EE+
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 632 RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
R L D + A +LA G A L T ++ L K+ + LR
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 676 -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
++R LE+ ++Q ++E QL +A ++ LE L E+ + R Q+++ +LA +
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 730 QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
E + +E +G+ NA R+K++ + +EAA + R
Sbjct: 1934 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1984
Query: 790 VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
Q E+ R+ L+ ++ L+ + E +LR++ E +A
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2037
Query: 846 ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
+A +R+ +++K +Q QQ+ V+D L + E + AE+
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Score = 33.5 bits (75), Expect = 1.0
Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
++ L K K+ E + L ++KD EE EK QV +S A +
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 295 TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
D+ ++ + L + M+A + ++ L Q + + +AR+L ++
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2353
Query: 353 AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
A+ L ++Q Q ER + M+ E LKL+V E +R + A +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 413 LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
+ + + EL TQ+ Q E ER + Q K L
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 451 SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
S Q +L + Q+SFL+E E+F+E A E L + + + E
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 508 ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
E R + + Q L S + ++ +A EE L Q+ ++
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2585
Query: 568 QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
L + N+ R+Q +L +E L ++V + A + L +
Sbjct: 2586 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645
Query: 612 HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
+G R V L G L+ E + + QGH D L R R L+G + ++
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2705
Query: 665 SGKKHLLQELREQRALEQGSSQCLDEHQ 692
+ +K + +++ L G++ L E Q
Sbjct: 2706 TNEKLSVYAALQRQLLSPGTALILLEAQ 2733
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 59.7 bits (143), Expect = 1e-08
Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)
Query: 291 SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
S+YI TL +E++ER +Q + E ++A ++ L Q + + +
Sbjct: 1299 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1354
Query: 338 --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
+A++L + E ++ E D+Q ELQ L + +A A+ E
Sbjct: 1355 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1414
Query: 386 KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
+L+++EE R RL + + EG+L R + E Q + +EAER R+
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474
Query: 444 G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
K LA +V+ A+ A E+QR+ A + E+ + +ER R +
Sbjct: 1475 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1531
Query: 501 QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
Q LE + R+ EA + + + ++ V L+ E +
Sbjct: 1532 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1589
Query: 556 YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
R+E + E WQL K+N R + + +E+ +Q E + R +
Sbjct: 1590 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1647
Query: 615 TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
+ V R L E R + +G +A +RLA L T+ ++ L
Sbjct: 1648 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1701
Query: 672 QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
+EL + ++Q E + +L +RA +L +R EEE++ T + +QRL AEA
Sbjct: 1702 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1761
Query: 730 QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
+L + E A +AL A R A + A+ R + +R L E AA+ T
Sbjct: 1762 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1818
Query: 783 SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
A ++ + +A +++ R+ ED EE+ QH ++ ER+ + EL
Sbjct: 1819 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1874
Query: 835 SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
R G +T + V + +L+ + F ++ L + ++ D L ++
Sbjct: 1875 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931
Query: 892 ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
+ +L+ A Q +LAA + + AE + ++ LE+ R K K
Sbjct: 1932 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 1985
Query: 940 PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
+E L ++ A Q + + KRL +E
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019
Score = 54.3 bits (129), Expect = 6e-07
Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)
Query: 336 SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
+ K QL +L E +A L + E +A E R + +E +L+ E R
Sbjct: 1554 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1612
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
RL A E +A + L+ + E+ Q + +EA R + E R ++L L
Sbjct: 1613 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1663
Query: 454 HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
Q EGTA+ LA E+E AE + + LE L+R+ +E
Sbjct: 1664 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1723
Query: 508 --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
VRA V+ A +E ST + ++ ++A F + L EE
Sbjct: 1724 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1783
Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
RQ +E+AA Q ++ R ++ E L+ + ++ ++E + L ED
Sbjct: 1784 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843
Query: 612 -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
H+ I L +L GL E++ R Q ++L A
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903
Query: 649 LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
A G A L R+ +EQ LE + L + + R E RV + +
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963
Query: 709 RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
EE A+Q + L++ RL A+ +E +L ++ + + Q L
Sbjct: 1964 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2008
Query: 767 FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
EAA + + + VQ +E++LQ +TLQ E+ +LR
Sbjct: 2009 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2048
Query: 827 KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
+ E +R A E ++ +R +Q +R + + +Q Q +A
Sbjct: 2049 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2102
Query: 887 LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
E + QEA + +E AAL + A++++ K+ E+ LR K
Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2149
Score = 52.0 bits (123), Expect = 3e-06
Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)
Query: 231 EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
EKH F + L K + + EL L +E D ++ L++ LQ +K TE +
Sbjct: 2136 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2189
Query: 288 AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
L V + E S+ +N + N Q FL ++ + K +Q+
Sbjct: 2190 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2245
Query: 344 MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
+AA+ ++ L+ L + RA K+++ VQE TR + A
Sbjct: 2246 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2297
Query: 404 LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
ELL QQ + ++A R +Q K+ + LA + +G +
Sbjct: 2298 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2336
Query: 464 LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
A+ + Q AEA ER +L ++ EE+ R +
Sbjct: 2337 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2379
Query: 518 ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
+ ++L+ + + T +K +QTL + + LR+ + E L + +
Sbjct: 2380 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2431
Query: 578 QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
Q+ KL Q E+ Q V E+ L+E T+ + L
Sbjct: 2432 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2466
Query: 638 HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
D LL+ R + L L Q ++ + L +E R+Q+ +EQ + + +
Sbjct: 2467 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525
Query: 697 RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
R EA E R +EE QQ Q +Q+ LLAE +E QLL++ A+ + V
Sbjct: 2526 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583
Query: 751 HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
A AATK+ RD EA E + G+ R V A Q I+ E ++L
Sbjct: 2584 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2640
Score = 48.9 bits (115), Expect = 2e-05
Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
+D +K+S E Q++ E +++ K Q + + + + +E ER
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1434
Query: 305 EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
+ + EA +Q L Q + S + RQ + L R+ A AE
Sbjct: 1435 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494
Query: 355 GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
+ LQAL+ L E R A+V ++QV ET R A EL +
Sbjct: 1495 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1550
Query: 411 GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
+ + Q E L ++H A Q EAER +++ + R ++ L Q++ L
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1610
Query: 463 TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
L A+E Q+ LA+A+ E EA E E Q + Q +L E+E + +
Sbjct: 1611 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667
Query: 515 AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
Q+ + + + L +T G E + R + + AA Q +
Sbjct: 1668 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1722
Query: 575 FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
+ + E+L + EE +S E G R + RL L EE+
Sbjct: 1723 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 632 RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
R L D + A +LA G A L T ++ L K+ + LR
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 676 -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
++R LE+ ++Q ++E QL +A ++ LE L E+ + R Q+++ +LA +
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1901
Query: 730 QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
E + +E +G+ NA R+K++ + +EAA + R
Sbjct: 1902 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1952
Query: 790 VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
Q E+ R+ L+ ++ L+ + E +LR++ E +A
Sbjct: 1953 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2005
Query: 846 ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
+A +R+ +++K +Q QQ+ V+D L + E + AE+
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060
Score = 33.5 bits (75), Expect = 1.0
Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
++ L K K+ E + L ++KD EE EK QV +S A +
Sbjct: 2205 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2264
Query: 295 TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
D+ ++ + L + M+A + ++ L Q + + +AR+L ++
Sbjct: 2265 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2321
Query: 353 AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
A+ L ++Q Q ER + M+ E LKL+V E +R + A +
Sbjct: 2322 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2380
Query: 413 LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
+ + + EL TQ+ Q E ER + Q K L
Sbjct: 2381 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440
Query: 451 SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
S Q +L + Q+SFL+E E+F+E A E L + + + E
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500
Query: 508 ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
E R + + Q L S + ++ +A EE L Q+ ++
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2553
Query: 568 QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
L + N+ R+Q +L +E L ++V + A + L +
Sbjct: 2554 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2613
Query: 612 HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
+G R V L G L+ E + + QGH D L R R L+G + ++
Sbjct: 2614 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2673
Query: 665 SGKKHLLQELREQRALEQGSSQCLDEHQ 692
+ +K + +++ L G++ L E Q
Sbjct: 2674 TNEKLSVYAALQRQLLSPGTALILLEAQ 2701
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 59.7 bits (143), Expect = 1e-08
Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)
Query: 291 SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
S+YI TL +E++ER +Q + E ++A ++ L Q + + +
Sbjct: 1468 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1523
Query: 338 --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
+A++L + E ++ E D+Q ELQ L + +A A+ E
Sbjct: 1524 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1583
Query: 386 KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
+L+++EE R RL + + EG+L R + E Q + +EAER R+
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643
Query: 444 G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
K LA +V+ A+ A E+QR+ A + E+ + +ER R +
Sbjct: 1644 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1700
Query: 501 QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
Q LE + R+ EA + + + ++ V L+ E +
Sbjct: 1701 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1758
Query: 556 YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
R+E + E WQL K+N R + + +E+ +Q E + R +
Sbjct: 1759 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1816
Query: 615 TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
+ V R L E R + +G +A +RLA L T+ ++ L
Sbjct: 1817 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1870
Query: 672 QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
+EL + ++Q E + +L +RA +L +R EEE++ T + +QRL AEA
Sbjct: 1871 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1930
Query: 730 QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
+L + E A +AL A R A + A+ R + +R L E AA+ T
Sbjct: 1931 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1987
Query: 783 SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
A ++ + +A +++ R+ ED EE+ QH ++ ER+ + EL
Sbjct: 1988 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 2043
Query: 835 SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
R G +T + V + +L+ + F ++ L + ++ D L ++
Sbjct: 2044 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100
Query: 892 ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
+ +L+ A Q +LAA + + AE + ++ LE+ R K K
Sbjct: 2101 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2154
Query: 940 PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
+E L ++ A Q + + KRL +E
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188
Score = 54.3 bits (129), Expect = 6e-07
Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)
Query: 336 SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
+ K QL +L E +A L + E +A E R + +E +L+ E R
Sbjct: 1723 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1781
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
RL A E +A + L+ + E+ Q + +EA R + E R ++L L
Sbjct: 1782 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1832
Query: 454 HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
Q EGTA+ LA E+E AE + + LE L+R+ +E
Sbjct: 1833 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1892
Query: 508 --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
VRA V+ A +E ST + ++ ++A F + L EE
Sbjct: 1893 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1952
Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
RQ +E+AA Q ++ R ++ E L+ + ++ ++E + L ED
Sbjct: 1953 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012
Query: 612 -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
H+ I L +L GL E++ R Q ++L A
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072
Query: 649 LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
A G A L R+ +EQ LE + L + + R E RV + +
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132
Query: 709 RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
EE A+Q + L++ RL A+ +E +L ++ + + Q L
Sbjct: 2133 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2177
Query: 767 FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
EAA + + + VQ +E++LQ +TLQ E+ +LR
Sbjct: 2178 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2217
Query: 827 KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
+ E +R A E ++ +R +Q +R + + +Q Q +A
Sbjct: 2218 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2271
Query: 887 LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
E + QEA + +E AAL + A++++ K+ E+ LR K
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2318
Score = 52.0 bits (123), Expect = 3e-06
Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)
Query: 231 EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
EKH F + L K + + EL L +E D ++ L++ LQ +K TE +
Sbjct: 2305 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2358
Query: 288 AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
L V + E S+ +N + N Q FL ++ + K +Q+
Sbjct: 2359 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2414
Query: 344 MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
+AA+ ++ L+ L + RA K+++ VQE TR + A
Sbjct: 2415 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2466
Query: 404 LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
ELL QQ + ++A R +Q K+ + LA + +G +
Sbjct: 2467 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2505
Query: 464 LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
A+ + Q AEA ER +L ++ EE+ R +
Sbjct: 2506 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2548
Query: 518 ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
+ ++L+ + + T +K +QTL + + LR+ + E L + +
Sbjct: 2549 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2600
Query: 578 QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
Q+ KL Q E+ Q V E+ L+E T+ + L
Sbjct: 2601 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2635
Query: 638 HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
D LL+ R + L L Q ++ + L +E R+Q+ +EQ + + +
Sbjct: 2636 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694
Query: 697 RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
R EA E R +EE QQ Q +Q+ LLAE +E QLL++ A+ + V
Sbjct: 2695 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752
Query: 751 HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
A AATK+ RD EA E + G+ R V A Q I+ E ++L
Sbjct: 2753 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2809
Score = 48.9 bits (115), Expect = 2e-05
Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
+D +K+S E Q++ E +++ K Q + + + + +E ER
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1603
Query: 305 EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
+ + EA +Q L Q + S + RQ + L R+ A AE
Sbjct: 1604 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663
Query: 355 GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
+ LQAL+ L E R A+V ++QV ET R A EL +
Sbjct: 1664 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1719
Query: 411 GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
+ + Q E L ++H A Q EAER +++ + R ++ L Q++ L
Sbjct: 1720 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1779
Query: 463 TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
L A+E Q+ LA+A+ E EA E E Q + Q +L E+E + +
Sbjct: 1780 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836
Query: 515 AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
Q+ + + + L +T G E + R + + AA Q +
Sbjct: 1837 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891
Query: 575 FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
+ + E+L + EE +S E G R + RL L EE+
Sbjct: 1892 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 632 RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
R L D + A +LA G A L T ++ L K+ + LR
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 676 -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
++R LE+ ++Q ++E QL +A ++ LE L E+ + R Q+++ +LA +
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 2070
Query: 730 QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
E + +E +G+ NA R+K++ + +EAA + R
Sbjct: 2071 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 2121
Query: 790 VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
Q E+ R+ L+ ++ L+ + E +LR++ E +A
Sbjct: 2122 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2174
Query: 846 ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
+A +R+ +++K +Q QQ+ V+D L + E + AE+
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229
Score = 33.5 bits (75), Expect = 1.0
Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
++ L K K+ E + L ++KD EE EK QV +S A +
Sbjct: 2374 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2433
Query: 295 TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
D+ ++ + L + M+A + ++ L Q + + +AR+L ++
Sbjct: 2434 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2490
Query: 353 AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
A+ L ++Q Q ER + M+ E LKL+V E +R + A +
Sbjct: 2491 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549
Query: 413 LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
+ + + EL TQ+ Q E ER + Q K L
Sbjct: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609
Query: 451 SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
S Q +L + Q+SFL+E E+F+E A E L + + + E
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669
Query: 508 ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
E R + + Q L S + ++ +A EE L Q+ ++
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2722
Query: 568 QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
L + N+ R+Q +L +E L ++V + A + L +
Sbjct: 2723 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2782
Query: 612 HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
+G R V L G L+ E + + QGH D L R R L+G + ++
Sbjct: 2783 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2842
Query: 665 SGKKHLLQELREQRALEQGSSQCLDEHQ 692
+ +K + +++ L G++ L E Q
Sbjct: 2843 TNEKLSVYAALQRQLLSPGTALILLEAQ 2870
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 59.7 bits (143), Expect = 1e-08
Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)
Query: 291 SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
S+YI TL +E++ER +Q + E ++A ++ L Q + + +
Sbjct: 1309 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1364
Query: 338 --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
+A++L + E ++ E D+Q ELQ L + +A A+ E
Sbjct: 1365 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1424
Query: 386 KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
+L+++EE R RL + + EG+L R + E Q + +EAER R+
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
Query: 444 G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
K LA +V+ A+ A E+QR+ A + E+ + +ER R +
Sbjct: 1485 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1541
Query: 501 QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
Q LE + R+ EA + + + ++ V L+ E +
Sbjct: 1542 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1599
Query: 556 YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
R+E + E WQL K+N R + + +E+ +Q E + R +
Sbjct: 1600 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1657
Query: 615 TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
+ V R L E R + +G +A +RLA L T+ ++ L
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1711
Query: 672 QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
+EL + ++Q E + +L +RA +L +R EEE++ T + +QRL AEA
Sbjct: 1712 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1771
Query: 730 QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
+L + E A +AL A R A + A+ R + +R L E AA+ T
Sbjct: 1772 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1828
Query: 783 SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
A ++ + +A +++ R+ ED EE+ QH ++ ER+ + EL
Sbjct: 1829 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1884
Query: 835 SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
R G +T + V + +L+ + F ++ L + ++ D L ++
Sbjct: 1885 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941
Query: 892 ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
+ +L+ A Q +LAA + + AE + ++ LE+ R K K
Sbjct: 1942 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 1995
Query: 940 PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
+E L ++ A Q + + KRL +E
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
Score = 54.3 bits (129), Expect = 6e-07
Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)
Query: 336 SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
+ K QL +L E +A L + E +A E R + +E +L+ E R
Sbjct: 1564 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1622
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
RL A E +A + L+ + E+ Q + +EA R + E R ++L L
Sbjct: 1623 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1673
Query: 454 HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
Q EGTA+ LA E+E AE + + LE L+R+ +E
Sbjct: 1674 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1733
Query: 508 --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
VRA V+ A +E ST + ++ ++A F + L EE
Sbjct: 1734 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1793
Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
RQ +E+AA Q ++ R ++ E L+ + ++ ++E + L ED
Sbjct: 1794 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1853
Query: 612 -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
H+ I L +L GL E++ R Q ++L A
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913
Query: 649 LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
A G A L R+ +EQ LE + L + + R E RV + +
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1973
Query: 709 RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
EE A+Q + L++ RL A+ +E +L ++ + + Q L
Sbjct: 1974 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2018
Query: 767 FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
EAA + + + VQ +E++LQ +TLQ E+ +LR
Sbjct: 2019 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2058
Query: 827 KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
+ E +R A E ++ +R +Q +R + + +Q Q +A
Sbjct: 2059 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2112
Query: 887 LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
E + QEA + +E AAL + A++++ K+ E+ LR K
Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2159
Score = 52.0 bits (123), Expect = 3e-06
Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)
Query: 231 EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
EKH F + L K + + EL L +E D ++ L++ LQ +K TE +
Sbjct: 2146 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2199
Query: 288 AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
L V + E S+ +N + N Q FL ++ + K +Q+
Sbjct: 2200 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2255
Query: 344 MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
+AA+ ++ L+ L + RA K+++ VQE TR + A
Sbjct: 2256 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2307
Query: 404 LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
ELL QQ + ++A R +Q K+ + LA + +G +
Sbjct: 2308 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2346
Query: 464 LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
A+ + Q AEA ER +L ++ EE+ R +
Sbjct: 2347 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2389
Query: 518 ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
+ ++L+ + + T +K +QTL + + LR+ + E L + +
Sbjct: 2390 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2441
Query: 578 QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
Q+ KL Q E+ Q V E+ L+E T+ + L
Sbjct: 2442 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2476
Query: 638 HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
D LL+ R + L L Q ++ + L +E R+Q+ +EQ + + +
Sbjct: 2477 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535
Query: 697 RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
R EA E R +EE QQ Q +Q+ LLAE +E QLL++ A+ + V
Sbjct: 2536 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593
Query: 751 HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
A AATK+ RD EA E + G+ R V A Q I+ E ++L
Sbjct: 2594 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2650
Score = 48.9 bits (115), Expect = 2e-05
Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
+D +K+S E Q++ E +++ K Q + + + + +E ER
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1444
Query: 305 EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
+ + EA +Q L Q + S + RQ + L R+ A AE
Sbjct: 1445 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1504
Query: 355 GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
+ LQAL+ L E R A+V ++QV ET R A EL +
Sbjct: 1505 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1560
Query: 411 GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
+ + Q E L ++H A Q EAER +++ + R ++ L Q++ L
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620
Query: 463 TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
L A+E Q+ LA+A+ E EA E E Q + Q +L E+E + +
Sbjct: 1621 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677
Query: 515 AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
Q+ + + + L +T G E + R + + AA Q +
Sbjct: 1678 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1732
Query: 575 FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
+ + E+L + EE +S E G R + RL L EE+
Sbjct: 1733 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 632 RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
R L D + A +LA G A L T ++ L K+ + LR
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 676 -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
++R LE+ ++Q ++E QL +A ++ LE L E+ + R Q+++ +LA +
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1911
Query: 730 QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
E + +E +G+ NA R+K++ + +EAA + R
Sbjct: 1912 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1962
Query: 790 VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
Q E+ R+ L+ ++ L+ + E +LR++ E +A
Sbjct: 1963 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2015
Query: 846 ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
+A +R+ +++K +Q QQ+ V+D L + E + AE+
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2070
Score = 33.5 bits (75), Expect = 1.0
Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
++ L K K+ E + L ++KD EE EK QV +S A +
Sbjct: 2215 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2274
Query: 295 TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
D+ ++ + L + M+A + ++ L Q + + +AR+L ++
Sbjct: 2275 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2331
Query: 353 AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
A+ L ++Q Q ER + M+ E LKL+V E +R + A +
Sbjct: 2332 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
Query: 413 LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
+ + + EL TQ+ Q E ER + Q K L
Sbjct: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2450
Query: 451 SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
S Q +L + Q+SFL+E E+F+E A E L + + + E
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510
Query: 508 ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
E R + + Q L S + ++ +A EE L Q+ ++
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2563
Query: 568 QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
L + N+ R+Q +L +E L ++V + A + L +
Sbjct: 2564 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2623
Query: 612 HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
+G R V L G L+ E + + QGH D L R R L+G + ++
Sbjct: 2624 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2683
Query: 665 SGKKHLLQELREQRALEQGSSQCLDEHQ 692
+ +K + +++ L G++ L E Q
Sbjct: 2684 TNEKLSVYAALQRQLLSPGTALILLEAQ 2711
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 59.7 bits (143), Expect = 1e-08
Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)
Query: 291 SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
S+YI TL +E++ER +Q + E ++A ++ L Q + + +
Sbjct: 1317 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1372
Query: 338 --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
+A++L + E ++ E D+Q ELQ L + +A A+ E
Sbjct: 1373 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1432
Query: 386 KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
+L+++EE R RL + + EG+L R + E Q + +EAER R+
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492
Query: 444 G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
K LA +V+ A+ A E+QR+ A + E+ + +ER R +
Sbjct: 1493 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1549
Query: 501 QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
Q LE + R+ EA + + + ++ V L+ E +
Sbjct: 1550 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1607
Query: 556 YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
R+E + E WQL K+N R + + +E+ +Q E + R +
Sbjct: 1608 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1665
Query: 615 TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
+ V R L E R + +G +A +RLA L T+ ++ L
Sbjct: 1666 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1719
Query: 672 QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
+EL + ++Q E + +L +RA +L +R EEE++ T + +QRL AEA
Sbjct: 1720 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1779
Query: 730 QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
+L + E A +AL A R A + A+ R + +R L E AA+ T
Sbjct: 1780 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1836
Query: 783 SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
A ++ + +A +++ R+ ED EE+ QH ++ ER+ + EL
Sbjct: 1837 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1892
Query: 835 SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
R G +T + V + +L+ + F ++ L + ++ D L ++
Sbjct: 1893 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949
Query: 892 ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
+ +L+ A Q +LAA + + AE + ++ LE+ R K K
Sbjct: 1950 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2003
Query: 940 PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
+E L ++ A Q + + KRL +E
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2037
Score = 54.3 bits (129), Expect = 6e-07
Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)
Query: 336 SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
+ K QL +L E +A L + E +A E R + +E +L+ E R
Sbjct: 1572 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1630
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
RL A E +A + L+ + E+ Q + +EA R + E R ++L L
Sbjct: 1631 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1681
Query: 454 HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
Q EGTA+ LA E+E AE + + LE L+R+ +E
Sbjct: 1682 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1741
Query: 508 --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
VRA V+ A +E ST + ++ ++A F + L EE
Sbjct: 1742 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1801
Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
RQ +E+AA Q ++ R ++ E L+ + ++ ++E + L ED
Sbjct: 1802 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1861
Query: 612 -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
H+ I L +L GL E++ R Q ++L A
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921
Query: 649 LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
A G A L R+ +EQ LE + L + + R E RV + +
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1981
Query: 709 RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
EE A+Q + L++ RL A+ +E +L ++ + + Q L
Sbjct: 1982 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2026
Query: 767 FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
EAA + + + VQ +E++LQ +TLQ E+ +LR
Sbjct: 2027 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2066
Query: 827 KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
+ E +R A E ++ +R +Q +R + + +Q Q +A
Sbjct: 2067 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2120
Query: 887 LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
E + QEA + +E AAL + A++++ K+ E+ LR K
Sbjct: 2121 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2167
Score = 52.0 bits (123), Expect = 3e-06
Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)
Query: 231 EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
EKH F + L K + + EL L +E D ++ L++ LQ +K TE +
Sbjct: 2154 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2207
Query: 288 AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
L V + E S+ +N + N Q FL ++ + K +Q+
Sbjct: 2208 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2263
Query: 344 MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
+AA+ ++ L+ L + RA K+++ VQE TR + A
Sbjct: 2264 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2315
Query: 404 LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
ELL QQ + ++A R +Q K+ + LA + +G +
Sbjct: 2316 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2354
Query: 464 LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
A+ + Q AEA ER +L ++ EE+ R +
Sbjct: 2355 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2397
Query: 518 ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
+ ++L+ + + T +K +QTL + + LR+ + E L + +
Sbjct: 2398 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2449
Query: 578 QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
Q+ KL Q E+ Q V E+ L+E T+ + L
Sbjct: 2450 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2484
Query: 638 HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
D LL+ R + L L Q ++ + L +E R+Q+ +EQ + + +
Sbjct: 2485 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543
Query: 697 RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
R EA E R +EE QQ Q +Q+ LLAE +E QLL++ A+ + V
Sbjct: 2544 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601
Query: 751 HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
A AATK+ RD EA E + G+ R V A Q I+ E ++L
Sbjct: 2602 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2658
Score = 48.9 bits (115), Expect = 2e-05
Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
+D +K+S E Q++ E +++ K Q + + + + +E ER
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1452
Query: 305 EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
+ + EA +Q L Q + S + RQ + L R+ A AE
Sbjct: 1453 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1512
Query: 355 GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
+ LQAL+ L E R A+V ++QV ET R A EL +
Sbjct: 1513 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1568
Query: 411 GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
+ + Q E L ++H A Q EAER +++ + R ++ L Q++ L
Sbjct: 1569 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1628
Query: 463 TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
L A+E Q+ LA+A+ E EA E E Q + Q +L E+E + +
Sbjct: 1629 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1685
Query: 515 AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
Q+ + + + L +T G E + R + + AA Q +
Sbjct: 1686 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1740
Query: 575 FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
+ + E+L + EE +S E G R + RL L EE+
Sbjct: 1741 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 632 RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
R L D + A +LA G A L T ++ L K+ + LR
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 676 -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
++R LE+ ++Q ++E QL +A ++ LE L E+ + R Q+++ +LA +
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1919
Query: 730 QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
E + +E +G+ NA R+K++ + +EAA + R
Sbjct: 1920 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1970
Query: 790 VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
Q E+ R+ L+ ++ L+ + E +LR++ E +A
Sbjct: 1971 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2023
Query: 846 ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
+A +R+ +++K +Q QQ+ V+D L + E + AE+
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2078
Score = 33.5 bits (75), Expect = 1.0
Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
++ L K K+ E + L ++KD EE EK QV +S A +
Sbjct: 2223 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2282
Query: 295 TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
D+ ++ + L + M+A + ++ L Q + + +AR+L ++
Sbjct: 2283 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2339
Query: 353 AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
A+ L ++Q Q ER + M+ E LKL+V E +R + A +
Sbjct: 2340 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2398
Query: 413 LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
+ + + EL TQ+ Q E ER + Q K L
Sbjct: 2399 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2458
Query: 451 SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
S Q +L + Q+SFL+E E+F+E A E L + + + E
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2518
Query: 508 ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
E R + + Q L S + ++ +A EE L Q+ ++
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2571
Query: 568 QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
L + N+ R+Q +L +E L ++V + A + L +
Sbjct: 2572 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2631
Query: 612 HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
+G R V L G L+ E + + QGH D L R R L+G + ++
Sbjct: 2632 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2691
Query: 665 SGKKHLLQELREQRALEQGSSQCLDEHQ 692
+ +K + +++ L G++ L E Q
Sbjct: 2692 TNEKLSVYAALQRQLLSPGTALILLEAQ 2719
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 59.7 bits (143), Expect = 1e-08
Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)
Query: 291 SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
S+YI TL +E++ER +Q + E ++A ++ L Q + + +
Sbjct: 1358 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1413
Query: 338 --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
+A++L + E ++ E D+Q ELQ L + +A A+ E
Sbjct: 1414 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1473
Query: 386 KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
+L+++EE R RL + + EG+L R + E Q + +EAER R+
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Query: 444 G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
K LA +V+ A+ A E+QR+ A + E+ + +ER R +
Sbjct: 1534 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1590
Query: 501 QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
Q LE + R+ EA + + + ++ V L+ E +
Sbjct: 1591 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1648
Query: 556 YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
R+E + E WQL K+N R + + +E+ +Q E + R +
Sbjct: 1649 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1706
Query: 615 TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
+ V R L E R + +G +A +RLA L T+ ++ L
Sbjct: 1707 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1760
Query: 672 QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
+EL + ++Q E + +L +RA +L +R EEE++ T + +QRL AEA
Sbjct: 1761 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1820
Query: 730 QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
+L + E A +AL A R A + A+ R + +R L E AA+ T
Sbjct: 1821 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1877
Query: 783 SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
A ++ + +A +++ R+ ED EE+ QH ++ ER+ + EL
Sbjct: 1878 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1933
Query: 835 SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
R G +T + V + +L+ + F ++ L + ++ D L ++
Sbjct: 1934 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990
Query: 892 ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
+ +L+ A Q +LAA + + AE + ++ LE+ R K K
Sbjct: 1991 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2044
Query: 940 PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
+E L ++ A Q + + KRL +E
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078
Score = 54.3 bits (129), Expect = 6e-07
Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)
Query: 336 SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
+ K QL +L E +A L + E +A E R + +E +L+ E R
Sbjct: 1613 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1671
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
RL A E +A + L+ + E+ Q + +EA R + E R ++L L
Sbjct: 1672 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1722
Query: 454 HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
Q EGTA+ LA E+E AE + + LE L+R+ +E
Sbjct: 1723 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782
Query: 508 --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
VRA V+ A +E ST + ++ ++A F + L EE
Sbjct: 1783 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1842
Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
RQ +E+AA Q ++ R ++ E L+ + ++ ++E + L ED
Sbjct: 1843 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1902
Query: 612 -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
H+ I L +L GL E++ R Q ++L A
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1962
Query: 649 LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
A G A L R+ +EQ LE + L + + R E RV + +
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2022
Query: 709 RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
EE A+Q + L++ RL A+ +E +L ++ + + Q L
Sbjct: 2023 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2067
Query: 767 FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
EAA + + + VQ +E++LQ +TLQ E+ +LR
Sbjct: 2068 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2107
Query: 827 KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
+ E +R A E ++ +R +Q +R + + +Q Q +A
Sbjct: 2108 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2161
Query: 887 LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
E + QEA + +E AAL + A++++ K+ E+ LR K
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2208
Score = 52.0 bits (123), Expect = 3e-06
Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)
Query: 231 EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
EKH F + L K + + EL L +E D ++ L++ LQ +K TE +
Sbjct: 2195 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2248
Query: 288 AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
L V + E S+ +N + N Q FL ++ + K +Q+
Sbjct: 2249 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2304
Query: 344 MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
+AA+ ++ L+ L + RA K+++ VQE TR + A
Sbjct: 2305 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2356
Query: 404 LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
ELL QQ + ++A R +Q K+ + LA + +G +
Sbjct: 2357 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2395
Query: 464 LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
A+ + Q AEA ER +L ++ EE+ R +
Sbjct: 2396 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2438
Query: 518 ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
+ ++L+ + + T +K +QTL + + LR+ + E L + +
Sbjct: 2439 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2490
Query: 578 QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
Q+ KL Q E+ Q V E+ L+E T+ + L
Sbjct: 2491 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2525
Query: 638 HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
D LL+ R + L L Q ++ + L +E R+Q+ +EQ + + +
Sbjct: 2526 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584
Query: 697 RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
R EA E R +EE QQ Q +Q+ LLAE +E QLL++ A+ + V
Sbjct: 2585 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642
Query: 751 HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
A AATK+ RD EA E + G+ R V A Q I+ E ++L
Sbjct: 2643 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2699
Score = 48.9 bits (115), Expect = 2e-05
Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
+D +K+S E Q++ E +++ K Q + + + + +E ER
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1493
Query: 305 EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
+ + EA +Q L Q + S + RQ + L R+ A AE
Sbjct: 1494 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1553
Query: 355 GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
+ LQAL+ L E R A+V ++QV ET R A EL +
Sbjct: 1554 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1609
Query: 411 GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
+ + Q E L ++H A Q EAER +++ + R ++ L Q++ L
Sbjct: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669
Query: 463 TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
L A+E Q+ LA+A+ E EA E E Q + Q +L E+E + +
Sbjct: 1670 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1726
Query: 515 AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
Q+ + + + L +T G E + R + + AA Q +
Sbjct: 1727 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1781
Query: 575 FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
+ + E+L + EE +S E G R + RL L EE+
Sbjct: 1782 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 632 RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
R L D + A +LA G A L T ++ L K+ + LR
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 676 -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
++R LE+ ++Q ++E QL +A ++ LE L E+ + R Q+++ +LA +
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1960
Query: 730 QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
E + +E +G+ NA R+K++ + +EAA + R
Sbjct: 1961 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 2011
Query: 790 VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
Q E+ R+ L+ ++ L+ + E +LR++ E +A
Sbjct: 2012 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2064
Query: 846 ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
+A +R+ +++K +Q QQ+ V+D L + E + AE+
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2119
Score = 33.5 bits (75), Expect = 1.0
Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)
Query: 245 LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
++ L K K+ E + L ++KD EE EK QV +S A +
Sbjct: 2264 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2323
Query: 295 TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
D+ ++ + L + M+A + ++ L Q + + +AR+L ++
Sbjct: 2324 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2380
Query: 353 AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
A+ L ++Q Q ER + M+ E LKL+V E +R + A +
Sbjct: 2381 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439
Query: 413 LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
+ + + EL TQ+ Q E ER + Q K L
Sbjct: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2499
Query: 451 SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
S Q +L + Q+SFL+E E+F+E A E L + + + E
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2559
Query: 508 ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
E R + + Q L S + ++ +A EE L Q+ ++
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2612
Query: 568 QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
L + N+ R+Q +L +E L ++V + A + L +
Sbjct: 2613 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2672
Query: 612 HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
+G R V L G L+ E + + QGH D L R R L+G + ++
Sbjct: 2673 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2732
Query: 665 SGKKHLLQELREQRALEQGSSQCLDEHQ 692
+ +K + +++ L G++ L E Q
Sbjct: 2733 TNEKLSVYAALQRQLLSPGTALILLEAQ 2760
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 59.3 bits (142), Expect = 2e-08
Identities = 150/724 (20%), Positives = 290/724 (40%), Gaps = 114/724 (15%)
Query: 244 LLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYIT-----LAD 298
L + L S+ E YQ +++ E+ L + ++ + N E+ +E+ T L +
Sbjct: 951 LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
Query: 299 VEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLC 358
VEK+++E + +E+ +Q++ ++ L ++ L+ A C
Sbjct: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRD--C 1068
Query: 359 DSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQK 418
Q A++A + R M + LQ +E ++A++ LE QK
Sbjct: 1069 QEQAKIAVEA-QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE--------ETTQK 1119
Query: 419 EELLTQQHKAFWQEAERFSREFV---------------------QRGKDLVTASLAHQVE 457
E + KA W+E ER ++ V ++ D V AS+ V+
Sbjct: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
Query: 458 GTAKLTLAQEEEQRSFLAEAQPTADPEKFL-EAFHEVLE------RQR--LMQCDLEE-- 506
G ++L++E + + + E EK + E EV + RQR L++ +L+E
Sbjct: 1180 GPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQ 1239
Query: 507 ------EENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQE 560
E V+ T +A +EL T +T ++ + EE + L Q+
Sbjct: 1240 DSLNAEREKVQVTAKTMAQHEELMKKT-ETMNVVMET---------NKMLREEKERLEQD 1289
Query: 561 VQENAA---------WQLGKSNRFRRQQWKLFQ---ELLEQDQQVWMEECALSSVLQTHL 608
+Q+ A L ++N ++ + Q +LLE+D + W A + L +
Sbjct: 1290 LQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWK---ARNQHLVSQQ 1346
Query: 609 REDHEGTIRGVLG-------RLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQ 661
++ R +L R+ LTEE R L+ R NA T Q
Sbjct: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGR-------------LKAEIARSNASLTNNQ 1393
Query: 662 MRLSGKKHLLQELR-EQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ 720
+ K L ++R E+ +++ + + Q ++ + + + R + + ++ + Q
Sbjct: 1394 NLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKI--GRRYKTQYEELKAQ 1451
Query: 721 LQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDR--DDFKRTLMEAAVES 778
+ + AQ G +QH+ Q L A TKS++ + ++ ++TL E E+
Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
Query: 779 VYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGS 838
+ V ++ R+ +D ++R Q + L+ + E + +K ++ S +
Sbjct: 1512 RNLQEQTVQ-----LQSELSRLRQDLQDRTTQE-EQLRQQITEKEEKTRKAIVAAKSKIA 1565
Query: 839 RTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHA-QQQQAGVMDLLEAQL-ETQLQ 896
AG + ++ L Q+ L Q +R+ A + Q G + LE +L E Q +
Sbjct: 1566 HLAGVKDQLTK--ENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQER 1623
Query: 897 EAEQ 900
EQ
Sbjct: 1624 HLEQ 1627
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 55.5 bits (132), Expect = 2e-07
Identities = 159/703 (22%), Positives = 266/703 (37%), Gaps = 118/703 (16%)
Query: 300 EKKEREYSE------QLIDNMEAFWKQMANIQHFL---VDQFKCSSSKARQLMMTLTERM 350
+K E+E SE L N+E + A+ + DQ + K +L L +
Sbjct: 1264 QKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADAS 1323
Query: 351 IAAEGLLCDSQELQAL----DAL--ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGL 404
L +S EL L + L + + G+A A+ +E L+ Q++EE++ + +A++H +
Sbjct: 1324 TQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAK-SALAHAV 1382
Query: 405 ELLAGEGKLSGRQKEE----------LLTQQHKAFWQEAERFSREFVQRGKDLVTAS--- 451
+ L + L Q EE LL++ + Q ++ + +QR ++L A
Sbjct: 1383 QALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKL 1442
Query: 452 ---LAHQVEGT------------AKLTLAQEEEQRSFLAEAQPTA-----DPEKFLE-AF 490
L EG AKL L E E + E +A ++ LE A
Sbjct: 1443 ALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERAL 1502
Query: 491 HEVLERQRLMQCDLE-------------------EEENVRATEAVVALCQELYFSTVD-T 530
E ++ MQ +LE EE + A E + + L D T
Sbjct: 1503 EERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLT 1562
Query: 531 FQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQD 590
Q + +Q L E ++ ++E + + R Q +L Q E D
Sbjct: 1563 DQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVD 1622
Query: 591 QQVWM--EECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCV---------LQGHD 639
+++ EECA +LR +H+ + + L T + L +
Sbjct: 1623 RKLAEKDEECA-------NLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE 1675
Query: 640 LLLRSALRRLALRGNALATLTQMRLSGKK-------HLLQELREQ-RALEQGSSQCLDEH 691
L L A R+ A A L Q +L ++ L EL EQ +ALE+ +S E
Sbjct: 1676 LQLGHATRQ-ATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAE- 1733
Query: 692 QWQLLRALEARVLEEASRLEEEAQQTRLQLQQRL-LAEAQEVGQLLQQHMECAIGQALLV 750
L L A LE+ R A+Q L+ +RL L +Q G LL Q + A L
Sbjct: 1734 ----LEELRA-ALEQGERSRRLAEQELLEATERLNLLHSQNTG-LLNQKKKLEADLAQLS 1787
Query: 751 HARNAATKSRAKDRDDFKRTLMEAAVESVYV-----TSAGVSRLVQAYYQQIGRIMEDHE 805
A + R + + K+ + +AA+ + + TSA + R+ + Q + + E
Sbjct: 1788 GEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLE 1847
Query: 806 ERKLQHLKTLQGERMENYKLRKK-QELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLA 864
E + L+G + + KL K +EL + H+R + + LA
Sbjct: 1848 EAE---QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKE----LA 1900
Query: 865 QFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELA 907
+ L Q + + Q +EAEQ + LA
Sbjct: 1901 YQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLA 1943
Score = 43.1 bits (100), Expect = 0.001
Identities = 135/630 (21%), Positives = 243/630 (38%), Gaps = 93/630 (14%)
Query: 247 LLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSN-----TEMSGAGDSEYITLADVEK 301
LL K K E K LS++ +D EE+ L + TE+ D +TLA EK
Sbjct: 956 LLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEK 1015
Query: 302 KEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQ 361
E++ +E + N+ ++MA + D+ +K ++ + ++ + L +
Sbjct: 1016 -EKQATENKVKNLT---EEMAAL-----DESVARLTKEKKALQEAHQQALG--DLQAEED 1064
Query: 362 ELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEEL 421
+ AL T + + + +E L+ +++E + R+ + + KL G K
Sbjct: 1065 RVSAL-----TKAKLRLEQQVEDLECSLEQEKKLRM-------DTERAKRKLEGDLK--- 1109
Query: 422 LTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTA 481
LTQ+ A + ++ E +++ KD + L+ +VE L +++ + A A+
Sbjct: 1110 LTQESVADAAQDKQQLEEKLKK-KDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELE 1168
Query: 482 DPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQ 541
+ + A +E+QR EE + R EA A +
Sbjct: 1169 EELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQ------------------- 1209
Query: 542 TLPGMTGLPPEECDY--LRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECA 599
G E + LR+E++E A RR+Q + EL EQ +
Sbjct: 1210 ----REGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVD-------S 1258
Query: 600 LSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGH-------DLLLRSALRRLALR 652
L V Q +E E +R + L E TR D L + ++ L+
Sbjct: 1259 LQRVRQKLEKEKSE--LRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQ 1316
Query: 653 GNALATLTQM-RLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLE 711
TQ RL + L L E++ +CL Q +AL A+ LEE R
Sbjct: 1317 RQLADASTQRGRLQTESGELSRLLEEK-------ECLIS-QLSRGKALAAQSLEELRRQL 1368
Query: 712 EEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTL 771
EE + + L + A + L +QH E A QA L + A A+ R ++
Sbjct: 1369 EEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADA 1428
Query: 772 MEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQEL 831
++ E L +A + R+ E E + + K E+ + + +++
Sbjct: 1429 IQRTEE-----------LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDV 1477
Query: 832 SNPSSGSRTAGGAHETSQAVHQRMLSQQKR 861
+ + +A A + Q +R L +++R
Sbjct: 1478 TLELERATSAAAALDKKQRHLERALEERRR 1507
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 54.7 bits (130), Expect = 4e-07
Identities = 73/305 (23%), Positives = 131/305 (42%), Gaps = 39/305 (12%)
Query: 638 HDLLLRSALRRLALRGNALATLTQMRLSGKKHL-LQELRE----QRALEQGSSQCLDEHQ 692
H L L + L+ A LTQ L +K L ELRE +RA E Q +H+
Sbjct: 243 HGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHE 302
Query: 693 WQLLRALEARVLEE-ASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVH 751
+LLR AR EE R +EA + + +LQ + AQ V + L++ E L
Sbjct: 303 LELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIV-KTLKEDWESEKDLCLENL 361
Query: 752 ARNAATKSRAKDRD---DFKRTLME--AAVESVYVT---------------SAGVSRLVQ 791
+ + K +++ D F++ L E A +E ++ A + +L +
Sbjct: 362 RKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRE 421
Query: 792 AYYQQIGRIMED-------HEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGA 844
+ GR +ED E+ K L+ LQ E+ K + ++E+ S +A +
Sbjct: 422 DLQSEHGRCLEDLEFKFKESEKEKQLELENLQAS-YEDLKAQSQEEIRRLWSQLDSARTS 480
Query: 845 HETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFIS 904
+ +H+++L++ R +Q++ + Q ++ L E +L++AE+ +
Sbjct: 481 RQELSELHEQLLARTSR----VEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQE 536
Query: 905 ELAAL 909
+L L
Sbjct: 537 DLTLL 541
Score = 43.5 bits (101), Expect = 0.001
Identities = 80/344 (23%), Positives = 154/344 (44%), Gaps = 46/344 (13%)
Query: 586 LLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLL--LR 643
LLE+ +++ E+ L HLR ++ L + L + LQ + L LR
Sbjct: 2487 LLERLEKIIREQGDLQEKSLEHLRLPDRSSL---LSEIQALRAQLRMTHLQNQEKLQHLR 2543
Query: 644 SALRRLALRGNAL-------ATLTQMRLSGKKHLLQELREQRALEQ---GSSQCLDEHQW 693
+AL RG+ L ++ +K + +L++ + EQ S Q L +
Sbjct: 2544 TALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQ 2603
Query: 694 QLLRALEARVLEEASRLEE------EAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQA 747
++R L++ + E + E+ E QQ LQL+ L ++ E+ LQ+ +E G+
Sbjct: 2604 TVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQE-LESEQGKG 2662
Query: 748 LLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEER 807
+ ++ + R R+ +E S+ A SRL A + + +D+ ++
Sbjct: 2663 RALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHE--QTAKDNLQK 2720
Query: 808 KLQHLKTLQGERMENYKLRKKQELSN-----PSSGSRTAGGAHETSQAV-HQRMLSQQ-K 860
+L+ ++ R E +++ +LS + SRT E S+A+ H+R+L++Q
Sbjct: 2721 ELR----IEHSRCEALLAQERSQLSELQKDLAAEKSRTL----ELSEALRHERLLTEQLS 2772
Query: 861 RFLAQFPVHQQMRLH------AQQQQAGVMDLLEAQLETQLQEA 898
+ + VHQ + H +++++ V+D L+A LE Q+A
Sbjct: 2773 QRTQEACVHQDTQAHHALLQKLKEEKSRVVD-LQAMLEKVQQQA 2815
Score = 37.0 bits (84), Expect = 0.092
Identities = 167/808 (20%), Positives = 308/808 (38%), Gaps = 162/808 (20%)
Query: 217 HLKDLLHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGL 276
H L L T L++E I++ K+ +L K + + L + + +E+ +K L
Sbjct: 677 HKVQLSLLQTELKEE-----IELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKEL 731
Query: 277 QVKLSNTEMSGAGDSEYITLADVEKKE--REYSEQLIDNMEAFWKQMANIQHFLVDQFKC 334
TE+ T V K+E RE E+L + ++ + + ++++F+
Sbjct: 732 NNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFEL 791
Query: 335 SSSKARQLMMTLTERMIAAEGLLCD--------SQELQALDALERTM-GR-AHMAKVIEF 384
++ RQL +++ E L + Q+L + DAL + GR A+ E
Sbjct: 792 REAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGEL 851
Query: 385 LKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKE--ELLTQQHKAFWQEA-ERFSREFV 441
L V+E+ L+L+ + +KE E + + AF QEA E+ +RE
Sbjct: 852 AALHVKEDC---------ALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQ 902
Query: 442 ------QRGKDLVTASL-AHQVEGTAKLTLAQEEEQRSFLA------EAQPTAD------ 482
Q+ VTA L A +LT + E +Q + LA + + AD
Sbjct: 903 LLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALET 962
Query: 483 ---------PEKFLEAFHEVLERQR----LMQCDLEEEENVRATEAVVALCQE---LYFS 526
+L F + E R L++ D EE+ + + L QE L
Sbjct: 963 RHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRK 1022
Query: 527 TVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQ------------EVQENAAWQLGKSNR 574
Q D L + + G E + Q E +E Q ++
Sbjct: 1023 HEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQP 1082
Query: 575 FRRQQWK-LFQELLEQDQQVW------------MEEC--ALSSVLQTHLREDHE------ 613
F +++ + L +L +++ QV +EEC L + Q RE+ E
Sbjct: 1083 FHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLS 1142
Query: 614 -------------GTIRGVLGRLGGLTEESTRCVL-------QGHDLLLRSALRRLAL-R 652
G ++ L RL GL E+ R + + L L A LAL
Sbjct: 1143 MLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALST 1202
Query: 653 GNAL-ATLTQMRLSGKKHLLQELREQRALEQGSS----------QCLDEHQWQLLRALEA 701
AL T + + L L E E ++ + SS + + E + + R ++
Sbjct: 1203 APALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQS 1262
Query: 702 RVLE---------EASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHA 752
L ++SR EEA+Q + ++ + +E Q++++H E L+
Sbjct: 1263 LSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQE-------LLEC 1315
Query: 753 RNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHL 812
+ ++A+ + +T + +E V +A + ++ ED E R + L
Sbjct: 1316 LKEESAAKAELALELHKT--QGTLEGFKVETADLKEVLAG--------KEDSEHRLVLEL 1365
Query: 813 KTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQM 872
++L+ R +++ L + + G A T + L ++ L + +
Sbjct: 1366 ESLR--RQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTK--EQSET 1421
Query: 873 RLHAQQQQAGV---MDLLEAQLETQLQE 897
R A++ ++ + M +LE++LE QL +
Sbjct: 1422 RKQAEKDRSALLSQMKILESELEEQLSQ 1449
Score = 34.3 bits (77), Expect = 0.60
Identities = 78/323 (24%), Positives = 124/323 (38%), Gaps = 61/323 (18%)
Query: 581 KLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLT--EESTRCVLQGH 638
+ Q LE++Q ++ + S+ LR E T R RL E++ + LQ
Sbjct: 2663 RALQSQLEEEQLRHLQRESQSAKALEELRASLE-TQRAQSSRLCVALKHEQTAKDNLQKE 2721
Query: 639 DLLLRSALRRLALRGNALATLTQMRLSGKK----HLLQELREQRALEQGSSQCLDE---H 691
+ S L + + + Q L+ +K L + LR +R L + SQ E H
Sbjct: 2722 LRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVH 2781
Query: 692 Q-WQLLRALEARVLEEASRLE------EEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAI 744
Q Q AL ++ EE SR+ E+ QQ L QQ+L AEAQ+ + L++ E
Sbjct: 2782 QDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKE--- 2838
Query: 745 GQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDH 804
SA + V+A + Q R +
Sbjct: 2839 -------------------------------------VSATLKSTVEALHTQ-KRELRCS 2860
Query: 805 EERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLA 864
ER+ + LQ E +++ K+QE + R+A + A R + K L
Sbjct: 2861 LEREREKPAWLQAELEQSHPRLKEQE--GRKAARRSAEARQSPAAAEQWRKWQRDKEKLR 2918
Query: 865 QFPVHQQMRLH-AQQQQAGVMDL 886
+ + +Q LH +Q Q V DL
Sbjct: 2919 ELELQRQRDLHKIKQLQQTVRDL 2941
Score = 30.4 bits (67), Expect = 8.6
Identities = 69/299 (23%), Positives = 115/299 (38%), Gaps = 35/299 (11%)
Query: 629 ESTRCVLQGHDLLLRSALRRLALRGNALATL--TQMRLSGKKHLLQELREQRALEQGSSQ 686
E T V++ H LL A + L TQ L G K +L+E A ++ S
Sbjct: 1300 EETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEH 1359
Query: 687 CLDEHQWQLLRALEAR------VLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHM 740
L L R L+ + EE +RL + T + R A +EV L ++
Sbjct: 1360 RLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQS 1419
Query: 741 ECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSR---LVQAYYQQI 797
E R A K R+ K ++E+ +E G ++ V A QQ+
Sbjct: 1420 E----------TRKQAEKDRSALLSQMK--ILESELEEQLSQHRGCAKQAEAVTALEQQV 1467
Query: 798 GRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAG-----GAHETSQAV- 851
++ H + Q + ER E+ + +QE+ R A G ++ QA
Sbjct: 1468 AS-LDKHLRNQRQFMDEQAAER-EHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPL 1525
Query: 852 -HQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAAL 909
+ L QQK + + + L Q++ A L++ + +L+E N ++A L
Sbjct: 1526 DGEVELLQQK---LREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQL 1581
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 52.8 bits (125), Expect = 2e-06
Identities = 188/895 (21%), Positives = 335/895 (37%), Gaps = 193/895 (21%)
Query: 131 ADGSSNPSLHENLKQAVLPHQPVEASP-------SSSLGSLSQGEKDDCSSSSSVHSATS 183
A S+ SL +N A + SP ++SL S E D S SS +S+ S
Sbjct: 265 APDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSDSSSYSSAS 324
Query: 184 DDR---FLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIF 240
LS+T + P ++ + + D +KD+L A Q++
Sbjct: 325 TRGTYGILSKT-VGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQ------ 377
Query: 241 KMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVE 300
++ + +S + +S + E E+ LQV + G ++ + +
Sbjct: 378 -----EVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQAL 432
Query: 301 KKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCS-SSKARQ------------------ 341
K++ E QL A + L Q +CS SS+ RQ
Sbjct: 433 KEKAELQAQL-----------AALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLE 481
Query: 342 LMMTLTERMIAAEG--LLCDSQELQ-ALDALERTMGRAHMAKVIEFLKLQVQEETRCRLA 398
MT + M+ A+ L + +LQ A + +R M + + K + R ++
Sbjct: 482 RAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMT 541
Query: 399 AISHGLE------------LLAGEGKLSGRQKEELLTQQHKAFWQEAE-RFSREF--VQR 443
A+ L+ L A + ++S Q QQ A QEA R E +Q
Sbjct: 542 ALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQV 601
Query: 444 GKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEA--------FHEVLE 495
G+ L H L+ E Q + E A + +EA F ++ E
Sbjct: 602 GQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQE 661
Query: 496 RQRLMQCDL---------EEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGM 546
+ +++ DL E E R ++ +L Q+L + V LQ +
Sbjct: 662 AKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQL---------EQVKLTLLQRDQQL 712
Query: 547 TGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQT 606
L E D ++Q L QE L+ +Q LQT
Sbjct: 713 EALQQEHLDLMKQLT--------------------LTQEALQSREQSL-------DALQT 745
Query: 607 HLREDHEGTIRGVLGRLGG--LTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRL 664
H E ++ LG L G + E T C+LQ ++L +AL+ L +
Sbjct: 746 HYDE-----LQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLE 800
Query: 665 SGKKHL---LQELREQRALEQGSSQCLDEH------QWQLLRA--LEARVLEEASRLEEE 713
G + L++LRE+ A++ G + L + Q Q ++ L+ +V+ EA R +
Sbjct: 801 EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDAT 860
Query: 714 AQQTRLQ----LQQRLLAEAQEVGQ-LLQQHMECAIGQALL--VHARNAATK-------- 758
++ + ++RL +E +E+ Q L+Q H E +A L +H A +
Sbjct: 861 SKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEG 920
Query: 759 ---SRAKDRDDFKRTLMEAAVES---VYVTSAG--VSRLVQAYYQQIGRIMEDHEERKLQ 810
S K+RD+ + L + V VT A + + ++ Q+ + + + +++ +
Sbjct: 921 HLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRR 980
Query: 811 ---HLKTLQGERMENYKL---------RKKQELSNPSSGS-------RTAGGAHETSQAV 851
L + Q E +K R+ QE + R GG+ ++S A+
Sbjct: 981 LGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLAL 1040
Query: 852 HQRMLS--------QQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEA 898
H+R+ + + L + + + + L +Q+ + +LE LE +LQE+
Sbjct: 1041 HERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLE--LEDELQES 1093
Score = 48.5 bits (114), Expect = 3e-05
Identities = 187/952 (19%), Positives = 363/952 (38%), Gaps = 128/952 (13%)
Query: 121 YPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHS 180
Y +N + P PS+ + L+ A HQ + + S +D SS S+ S
Sbjct: 343 YMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRS----RRDSICSSVSLES 398
Query: 181 ATSDDRF----LSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMF 236
+ ++ + + + +R+ E L+ E+ S LK+ L L +
Sbjct: 399 SAAETQEEMLQVLKEKMRLEGQLEALSLEA--------SQALKEKAELQAQLAALSTKLQ 450
Query: 237 IQIFKMCLLDLLPKKKSDDELYQKILSKQEK--DLEELEKGLQVKLSNTEMSGAGDSEYI 294
Q+ C ++ D L ++ + ++ DLE LQ L S A +
Sbjct: 451 AQV--ECSHS---SQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNN-- 503
Query: 295 TLADVEKKEREYSEQL--IDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMM---TLTER 349
D++ E +Y + +++M+ N H L Q S+ +Q+ + TLT +
Sbjct: 504 ---DLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSK 560
Query: 350 MIAAEGLLCDSQELQ---------ALDALERTMGR-AHM-------AKVIEFLKL----- 387
+ A++ + Q ++ A +A R G AH+ A ++E LKL
Sbjct: 561 LKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSL 620
Query: 388 --QVQE------ETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFS-- 437
Q+ E + + R+AA G+E + + + Q +E T + + E F
Sbjct: 621 SQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGE 680
Query: 438 REFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQ 497
RE +QR D ASL Q+E KLTL Q ++Q L Q D K L E L+ +
Sbjct: 681 RERLQRMADSA-ASLEQQLE-QVKLTLLQRDQQLEAL--QQEHLDLMKQLTLTQEALQSR 736
Query: 498 R----LMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLP--- 550
+Q +E + A +E + + ++A G L
Sbjct: 737 EQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGA 796
Query: 551 ------PEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVL 604
EE ++++E A + G+ +++ L +++ + +Q ++ + +
Sbjct: 797 RRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYR 856
Query: 605 QTHLREDH-EGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMR 663
+ +D ++ RL +E + ++Q H R+A L+ +A + Q
Sbjct: 857 RDATSKDQLISELKATRKRLDSELKELRQELMQVHG-EKRTAEAELSRLHREVAQVRQHM 915
Query: 664 LSGKKHLLQELREQRALEQG-SSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQ 722
+ HL +E+ +E S D+ Q + + ++ L++EA++ + +
Sbjct: 916 ADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQK 975
Query: 723 QRL------LAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRD----------- 765
Q++ L AQ+ + + E A+G L + A A D +
Sbjct: 976 QKMRRLGSDLTSAQKEMKTKHKAYENAVG-ILSRRLQEALAAKEAADAELGQLRAQGGSS 1034
Query: 766 DFKRTL------MEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGER 819
D L +EA +++V + + + +Q + +E+ E+ L+ LQ R
Sbjct: 1035 DSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESR 1094
Query: 820 MENYKLRKKQELSNP-------SSGSRTAGGAHETSQAVH----QRMLSQQKRFLAQFPV 868
K+++ +E + G T G + H + L++++ L Q +
Sbjct: 1095 GFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNL 1154
Query: 869 HQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ--NFISELAALARVPLAES----KLLPA 922
Q L ++++ M L L+ L++ ++ N + E A A+V + K
Sbjct: 1155 QVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASL 1214
Query: 923 KRGLLEKPLRTKRK--KPLPQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQ 972
+ ++K L+ K + L E DL + + Q L+ R Q
Sbjct: 1215 ELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQ 1266
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 52.0 bits (123), Expect = 3e-06
Identities = 175/791 (22%), Positives = 312/791 (39%), Gaps = 120/791 (15%)
Query: 246 DLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGA--GDSEYITLADVEKKE 303
D L K++ + +K+ + + + EL++ + + E A G E A + + E
Sbjct: 1066 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1125
Query: 304 REYSE--QLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQ 361
E QL+ ++ +A Q L + + + +KA + L E + A G L D+
Sbjct: 1126 DEGGARAQLLKSLREAQAALAEAQEDLESE-RVARTKAEKQRRDLGEELEALRGELEDT- 1183
Query: 362 ELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEEL 421
L + +A + R+ + + LK ++EETR AA+ EL G+ G E+L
Sbjct: 1184 -LDSTNAQQEL--RSKREQEVTELKKTLEEETRIHEAAVQ---ELRQRHGQALGELAEQL 1237
Query: 422 LTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQ--- 478
++A R + + L + E ++ T QE EQR E Q
Sbjct: 1238 ---------EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQE 1288
Query: 479 ---PTADPEKFLEAFHEVLERQRLMQCDLEEEENV--RATEAVVALCQELYFSTVDTFQK 533
D E+ A E E+ + Q +LE A + L +EL ST
Sbjct: 1289 VQGRAGDGER---ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS-STEAQLHD 1344
Query: 534 FVDALFLQT-----LPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLE 588
+ L +T L E LR++++E AA + + Q +L +
Sbjct: 1345 AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1404
Query: 589 QDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRR 648
Q++ E AL + + R E + RL TE R L RR
Sbjct: 1405 QEE----EAGALEAGEEARRRAAREA--EALTQRLAEKTETVDR---------LERGRRR 1449
Query: 649 LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
L L T M L ++ L+ L ++ ++ Q L E + +LRA+E R EA
Sbjct: 1450 LQ---QELDDAT-MDLEQQRQLVSTLEKK---QRKFDQLLAEEKAAVLRAVEERERAEAE 1502
Query: 709 RLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMEC--AIGQALL---------VHARNAAT 757
E EA+ L R L E QE + L++ A +ALL VH A
Sbjct: 1503 GREREARALSLT---RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1559
Query: 758 KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL-----VQAYYQQIGRIMEDH----EERK 808
+ + +D + + E E +T+A ++L VQA Q R ++ EER+
Sbjct: 1560 RVAEQAANDLRAQVTELEDE---LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERR 1616
Query: 809 LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPV 868
Q K L+ +E + RK++ L + A +++ + + AQ
Sbjct: 1617 RQLAKQLRDAEVERDEERKQRTL----------------AVAARKKLEGELEELKAQMAS 1660
Query: 869 HQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLL- 927
Q + A +Q + ++AQ++ +E E+ S ++ +E +L + +L
Sbjct: 1661 AGQGKEEAVKQ----LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1716
Query: 928 ---EKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSSK------RLSQQESEAGD 978
E + ++ Q+R ++ +++A+G+ + ++ + RL Q E E +
Sbjct: 1717 LQEELAASDRARRQAQQDRDEMA----DEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1772
Query: 979 SGNSKKMLKRR 989
++ ++L R
Sbjct: 1773 EQSNSELLNDR 1783
Score = 47.8 bits (112), Expect = 5e-05
Identities = 147/671 (21%), Positives = 255/671 (38%), Gaps = 72/671 (10%)
Query: 354 EGLLCDSQELQALDALERTMGRA-------------HMAKVIEFLKLQVQ-----EETRC 395
E L +QELQ + L++ R A++ E L+ + + EETR
Sbjct: 877 EVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRG 936
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQ 455
RLAA LEL+ E + ++EE Q E +R + + L A Q
Sbjct: 937 RLAARKQELELVVSELEARVGEEEECSRQMQ----TEKKRLQQHIQELEAHLEAEEGARQ 992
Query: 456 VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCD---LEEEENVRA 512
K+T E + + F + D L ++LE RL + EEEE V++
Sbjct: 993 KLQLEKVT--TEAKMKKFEEDLLLLEDQNSKLSKERKLLE-DRLAEFSSQAAEEEEKVKS 1049
Query: 513 TEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKS 572
+ + D +K + Q L + D E+QE Q ++
Sbjct: 1050 LNKLRLKYEATIADMEDRLRK--EEKGRQELEKL----KRRLDGESSELQEQMVEQQQRA 1103
Query: 573 NRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTR 632
R Q + +EL + E A + +L++ LRE + + L T+
Sbjct: 1104 EELRAQLGRKEEELQAALARAEDEGGARAQLLKS-LRE-AQAALAEAQEDLESERVARTK 1161
Query: 633 CVLQGHDL-----LLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQ--------RA 679
Q DL LR L NA L R L + L E+ +
Sbjct: 1162 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1221
Query: 680 LEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQH 739
L Q Q L E QL +A + E +RL EA+ + L+ + L A++ G+ ++
Sbjct: 1222 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1281
Query: 740 MECAI-------GQALLVHARNAATKSRAK-DRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
+E + G A A RA+ + ++ L EA +++ ++ S Q
Sbjct: 1282 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1341
Query: 792 AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAV 851
+ Q ++++ KL ++ E LR ++L ++ AG +T+QA
Sbjct: 1342 LHDAQ--ELLQEETRAKLALGSRVRAMEAEAAGLR--EQLEEEAAARERAGRELQTAQAQ 1397
Query: 852 HQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLET--QLQEAEQNFISELAAL 909
+Q+ ++ R A ++ + L + ET +L+ + EL
Sbjct: 1398 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD- 1456
Query: 910 ARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDL--GVPNNE--DLASGDQTSGSLS 965
A + L + + L + LEK R K + L +E+ + V E + ++ + +LS
Sbjct: 1457 ATMDLEQQRQLVS---TLEKKQR-KFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1512
Query: 966 SKRLSQQESEA 976
R ++E EA
Sbjct: 1513 LTRALEEEQEA 1523
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 52.0 bits (123), Expect = 3e-06
Identities = 175/791 (22%), Positives = 312/791 (39%), Gaps = 120/791 (15%)
Query: 246 DLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGA--GDSEYITLADVEKKE 303
D L K++ + +K+ + + + EL++ + + E A G E A + + E
Sbjct: 1058 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1117
Query: 304 REYSE--QLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQ 361
E QL+ ++ +A Q L + + + +KA + L E + A G L D+
Sbjct: 1118 DEGGARAQLLKSLREAQAALAEAQEDLESE-RVARTKAEKQRRDLGEELEALRGELEDT- 1175
Query: 362 ELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEEL 421
L + +A + R+ + + LK ++EETR AA+ EL G+ G E+L
Sbjct: 1176 -LDSTNAQQEL--RSKREQEVTELKKTLEEETRIHEAAVQ---ELRQRHGQALGELAEQL 1229
Query: 422 LTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQ--- 478
++A R + + L + E ++ T QE EQR E Q
Sbjct: 1230 ---------EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQE 1280
Query: 479 ---PTADPEKFLEAFHEVLERQRLMQCDLEEEENV--RATEAVVALCQELYFSTVDTFQK 533
D E+ A E E+ + Q +LE A + L +EL ST
Sbjct: 1281 VQGRAGDGER---ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS-STEAQLHD 1336
Query: 534 FVDALFLQT-----LPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLE 588
+ L +T L E LR++++E AA + + Q +L +
Sbjct: 1337 AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1396
Query: 589 QDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRR 648
Q++ E AL + + R E + RL TE R L RR
Sbjct: 1397 QEE----EAGALEAGEEARRRAAREA--EALTQRLAEKTETVDR---------LERGRRR 1441
Query: 649 LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
L L T M L ++ L+ L ++ ++ Q L E + +LRA+E R EA
Sbjct: 1442 LQ---QELDDAT-MDLEQQRQLVSTLEKK---QRKFDQLLAEEKAAVLRAVEERERAEAE 1494
Query: 709 RLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMEC--AIGQALL---------VHARNAAT 757
E EA+ L R L E QE + L++ A +ALL VH A
Sbjct: 1495 GREREARALSLT---RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1551
Query: 758 KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL-----VQAYYQQIGRIMEDH----EERK 808
+ + +D + + E E +T+A ++L VQA Q R ++ EER+
Sbjct: 1552 RVAEQAANDLRAQVTELEDE---LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERR 1608
Query: 809 LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPV 868
Q K L+ +E + RK++ L + A +++ + + AQ
Sbjct: 1609 RQLAKQLRDAEVERDEERKQRTL----------------AVAARKKLEGELEELKAQMAS 1652
Query: 869 HQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLL- 927
Q + A +Q + ++AQ++ +E E+ S ++ +E +L + +L
Sbjct: 1653 AGQGKEEAVKQ----LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1708
Query: 928 ---EKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSSK------RLSQQESEAGD 978
E + ++ Q+R ++ +++A+G+ + ++ + RL Q E E +
Sbjct: 1709 LQEELAASDRARRQAQQDRDEMA----DEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1764
Query: 979 SGNSKKMLKRR 989
++ ++L R
Sbjct: 1765 EQSNSELLNDR 1775
Score = 47.8 bits (112), Expect = 5e-05
Identities = 147/671 (21%), Positives = 255/671 (38%), Gaps = 72/671 (10%)
Query: 354 EGLLCDSQELQALDALERTMGRA-------------HMAKVIEFLKLQVQ-----EETRC 395
E L +QELQ + L++ R A++ E L+ + + EETR
Sbjct: 869 EVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRG 928
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQ 455
RLAA LEL+ E + ++EE Q E +R + + L A Q
Sbjct: 929 RLAARKQELELVVSELEARVGEEEECSRQMQ----TEKKRLQQHIQELEAHLEAEEGARQ 984
Query: 456 VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCD---LEEEENVRA 512
K+T E + + F + D L ++LE RL + EEEE V++
Sbjct: 985 KLQLEKVT--TEAKMKKFEEDLLLLEDQNSKLSKERKLLE-DRLAEFSSQAAEEEEKVKS 1041
Query: 513 TEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKS 572
+ + D +K + Q L + D E+QE Q ++
Sbjct: 1042 LNKLRLKYEATIADMEDRLRK--EEKGRQELEKL----KRRLDGESSELQEQMVEQQQRA 1095
Query: 573 NRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTR 632
R Q + +EL + E A + +L++ LRE + + L T+
Sbjct: 1096 EELRAQLGRKEEELQAALARAEDEGGARAQLLKS-LRE-AQAALAEAQEDLESERVARTK 1153
Query: 633 CVLQGHDL-----LLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQ--------RA 679
Q DL LR L NA L R L + L E+ +
Sbjct: 1154 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1213
Query: 680 LEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQH 739
L Q Q L E QL +A + E +RL EA+ + L+ + L A++ G+ ++
Sbjct: 1214 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1273
Query: 740 MECAI-------GQALLVHARNAATKSRAK-DRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
+E + G A A RA+ + ++ L EA +++ ++ S Q
Sbjct: 1274 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1333
Query: 792 AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAV 851
+ Q ++++ KL ++ E LR ++L ++ AG +T+QA
Sbjct: 1334 LHDAQ--ELLQEETRAKLALGSRVRAMEAEAAGLR--EQLEEEAAARERAGRELQTAQAQ 1389
Query: 852 HQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLET--QLQEAEQNFISELAAL 909
+Q+ ++ R A ++ + L + ET +L+ + EL
Sbjct: 1390 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD- 1448
Query: 910 ARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDL--GVPNNE--DLASGDQTSGSLS 965
A + L + + L + LEK R K + L +E+ + V E + ++ + +LS
Sbjct: 1449 ATMDLEQQRQLVS---TLEKKQR-KFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1504
Query: 966 SKRLSQQESEA 976
R ++E EA
Sbjct: 1505 LTRALEEEQEA 1515
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 52.0 bits (123), Expect = 3e-06
Identities = 175/791 (22%), Positives = 312/791 (39%), Gaps = 120/791 (15%)
Query: 246 DLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGA--GDSEYITLADVEKKE 303
D L K++ + +K+ + + + EL++ + + E A G E A + + E
Sbjct: 1099 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1158
Query: 304 REYSE--QLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQ 361
E QL+ ++ +A Q L + + + +KA + L E + A G L D+
Sbjct: 1159 DEGGARAQLLKSLREAQAALAEAQEDLESE-RVARTKAEKQRRDLGEELEALRGELEDT- 1216
Query: 362 ELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEEL 421
L + +A + R+ + + LK ++EETR AA+ EL G+ G E+L
Sbjct: 1217 -LDSTNAQQEL--RSKREQEVTELKKTLEEETRIHEAAVQ---ELRQRHGQALGELAEQL 1270
Query: 422 LTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQ--- 478
++A R + + L + E ++ T QE EQR E Q
Sbjct: 1271 ---------EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQE 1321
Query: 479 ---PTADPEKFLEAFHEVLERQRLMQCDLEEEENV--RATEAVVALCQELYFSTVDTFQK 533
D E+ A E E+ + Q +LE A + L +EL ST
Sbjct: 1322 VQGRAGDGER---ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS-STEAQLHD 1377
Query: 534 FVDALFLQT-----LPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLE 588
+ L +T L E LR++++E AA + + Q +L +
Sbjct: 1378 AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1437
Query: 589 QDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRR 648
Q++ E AL + + R E + RL TE R L RR
Sbjct: 1438 QEE----EAGALEAGEEARRRAAREA--EALTQRLAEKTETVDR---------LERGRRR 1482
Query: 649 LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
L L T M L ++ L+ L ++ ++ Q L E + +LRA+E R EA
Sbjct: 1483 LQ---QELDDAT-MDLEQQRQLVSTLEKK---QRKFDQLLAEEKAAVLRAVEERERAEAE 1535
Query: 709 RLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMEC--AIGQALL---------VHARNAAT 757
E EA+ L R L E QE + L++ A +ALL VH A
Sbjct: 1536 GREREARALSLT---RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1592
Query: 758 KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL-----VQAYYQQIGRIMEDH----EERK 808
+ + +D + + E E +T+A ++L VQA Q R ++ EER+
Sbjct: 1593 RVAEQAANDLRAQVTELEDE---LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERR 1649
Query: 809 LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPV 868
Q K L+ +E + RK++ L + A +++ + + AQ
Sbjct: 1650 RQLAKQLRDAEVERDEERKQRTL----------------AVAARKKLEGELEELKAQMAS 1693
Query: 869 HQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLL- 927
Q + A +Q + ++AQ++ +E E+ S ++ +E +L + +L
Sbjct: 1694 AGQGKEEAVKQ----LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1749
Query: 928 ---EKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSSK------RLSQQESEAGD 978
E + ++ Q+R ++ +++A+G+ + ++ + RL Q E E +
Sbjct: 1750 LQEELAASDRARRQAQQDRDEMA----DEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1805
Query: 979 SGNSKKMLKRR 989
++ ++L R
Sbjct: 1806 EQSNSELLNDR 1816
Score = 47.8 bits (112), Expect = 5e-05
Identities = 147/671 (21%), Positives = 255/671 (38%), Gaps = 72/671 (10%)
Query: 354 EGLLCDSQELQALDALERTMGRA-------------HMAKVIEFLKLQVQ-----EETRC 395
E L +QELQ + L++ R A++ E L+ + + EETR
Sbjct: 910 EVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRG 969
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQ 455
RLAA LEL+ E + ++EE Q E +R + + L A Q
Sbjct: 970 RLAARKQELELVVSELEARVGEEEECSRQMQ----TEKKRLQQHIQELEAHLEAEEGARQ 1025
Query: 456 VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCD---LEEEENVRA 512
K+T E + + F + D L ++LE RL + EEEE V++
Sbjct: 1026 KLQLEKVT--TEAKMKKFEEDLLLLEDQNSKLSKERKLLE-DRLAEFSSQAAEEEEKVKS 1082
Query: 513 TEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKS 572
+ + D +K + Q L + D E+QE Q ++
Sbjct: 1083 LNKLRLKYEATIADMEDRLRK--EEKGRQELEKL----KRRLDGESSELQEQMVEQQQRA 1136
Query: 573 NRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTR 632
R Q + +EL + E A + +L++ LRE + + L T+
Sbjct: 1137 EELRAQLGRKEEELQAALARAEDEGGARAQLLKS-LRE-AQAALAEAQEDLESERVARTK 1194
Query: 633 CVLQGHDL-----LLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQ--------RA 679
Q DL LR L NA L R L + L E+ +
Sbjct: 1195 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1254
Query: 680 LEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQH 739
L Q Q L E QL +A + E +RL EA+ + L+ + L A++ G+ ++
Sbjct: 1255 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1314
Query: 740 MECAI-------GQALLVHARNAATKSRAK-DRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
+E + G A A RA+ + ++ L EA +++ ++ S Q
Sbjct: 1315 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1374
Query: 792 AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAV 851
+ Q ++++ KL ++ E LR ++L ++ AG +T+QA
Sbjct: 1375 LHDAQ--ELLQEETRAKLALGSRVRAMEAEAAGLR--EQLEEEAAARERAGRELQTAQAQ 1430
Query: 852 HQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLET--QLQEAEQNFISELAAL 909
+Q+ ++ R A ++ + L + ET +L+ + EL
Sbjct: 1431 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD- 1489
Query: 910 ARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDL--GVPNNE--DLASGDQTSGSLS 965
A + L + + L + LEK R K + L +E+ + V E + ++ + +LS
Sbjct: 1490 ATMDLEQQRQLVS---TLEKKQR-KFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1545
Query: 966 SKRLSQQESEA 976
R ++E EA
Sbjct: 1546 LTRALEEEQEA 1556
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 49.7 bits (117), Expect = 1e-05
Identities = 136/706 (19%), Positives = 268/706 (37%), Gaps = 53/706 (7%)
Query: 222 LHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLS 281
+ L AL +++ + + L L +K+ D+ K+ + ++ELE+ Q
Sbjct: 1032 MRLQNALNEQR--VEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ 1089
Query: 282 NTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQ 341
E + E+ + + + + +E +EA +++ ++ Q + + S R
Sbjct: 1090 LKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS 1149
Query: 342 L---MMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCR-- 396
L + ER A E L +E +A + A + + + +VQ+ ++
Sbjct: 1150 LEAERASRAERDSALETLQGQLEE-KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE 1208
Query: 397 -LAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQ 455
A ++ G + + L +EE+ + +E E S+E K LV A
Sbjct: 1209 WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGE--SKEL----KRLVMAESEKS 1262
Query: 456 VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEA 515
+ +L L Q E + A+ ++ + +++ E E+QR+ +L +E +A E
Sbjct: 1263 QKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQA-ER 1321
Query: 516 VVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRF 575
L QEL FQK LQ T E + Q+ A Q R
Sbjct: 1322 AEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH 1381
Query: 576 RRQQWKLFQELLEQDQQVWMEECALSSVLQTHLR-EDHEGTIRGVLGRLGGLTEESTRCV 634
R + + Q ++ + L ++ + + E T + + E+ + +
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSM-L 1440
Query: 635 LQGHDLLLRSALRRLALRGNALATLTQMRLS-GKKHLLQELREQRALEQGSSQCLDEHQW 693
+ H LL R L R N ++ L ++ +QEL RA + +
Sbjct: 1441 KKAHGLLAEEN-RGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQ 1499
Query: 694 QLLRALEA----------RVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECA 743
R LE +VLEE R +EE Q+ Q++Q + + ++ Q+ + + A
Sbjct: 1500 STARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1559
Query: 744 -IGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIME 802
QA V + + ++A + + + + + Y Q+ +
Sbjct: 1560 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT 1619
Query: 803 DHEERKLQH------LKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRML 856
++ +K Q+ L++L+ + EN +LR + E HE QA +
Sbjct: 1620 HYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERL-----------GHELQQAGLKTKE 1668
Query: 857 SQQ--KRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
++Q + AQ + HA QQ + DL + Q+ T ++ +
Sbjct: 1669 AEQTCRHLTAQVRSLEAQVAHADQQ---LRDLGKFQVATDALKSRE 1711
Score = 45.8 bits (107), Expect = 2e-04
Identities = 141/740 (19%), Positives = 275/740 (37%), Gaps = 72/740 (9%)
Query: 262 LSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQM 321
LS K E+ K + K T A + T A+ + + + +EA K+
Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHA--QQLATAAEEREASLRERDAALKQLEALEKEK 613
Query: 322 ANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKV 381
A L Q + ++ ++T+ L +ELQA R A+V
Sbjct: 614 AAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQV 673
Query: 382 IEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFV 441
E L+LQ++ E + A E + ++K++L Q+ +E+ + ++ +
Sbjct: 674 AE-LELQLRSEQQ------------KATEKERVAQEKDQL--QEQLQALKESLKVTKGSL 718
Query: 442 QRGKDLVTASLAHQVEGTAKL---TLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQR 498
+ K +L Q ++L T + E+ + E + K LEA + L
Sbjct: 719 EEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAH 778
Query: 499 LMQCDL---EEEENVRATEAVVALCQELYFSTVDTFQKFVD---------ALFLQTLPGM 546
+ ++ E E + A + C++L +++ D A+F + L +
Sbjct: 779 QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTL 838
Query: 547 TGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQT 606
EEC+ RQE+QE G + Q + EL E + AL V +
Sbjct: 839 K----EECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANL---ARALQQVQEK 891
Query: 607 HLR-EDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLS 665
+R + + + ++ ++E R + L+R A + L
Sbjct: 892 EVRAQKLADDLSTLQEKMAATSKEVARL-----ETLVRKAGEQQETASRELVKEPARAGD 946
Query: 666 GKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRL 725
+ L+E +QG C + Q + ++ E RL +++ Q Q+
Sbjct: 947 RQPEWLEE-------QQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEER 999
Query: 726 LAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAG 785
+ +EV +L Q+ G+A A A ++ + R + L E VE + A
Sbjct: 1000 GQQEREVARLTQER-----GRAQADLALEKAARAELEMR--LQNALNEQRVEFATLQEAL 1052
Query: 786 VSRLV--QAYYQQIGRI--MEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTA 841
L + Q++ ++ +E + ++L+ L+ + E ++K+ S + S A
Sbjct: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAA 1112
Query: 842 GGAHETSQAVHQ-----RMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQ 896
G T + L QQ + + + L A++ D L+ QL+
Sbjct: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172
Query: 897 EAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLAS 956
E Q +ALA + + L A R ++ + + + RG L S
Sbjct: 1173 EKAQELGHSQSALA----SAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228
Query: 957 GDQTSGSLSSKRLSQQESEA 976
+ S+ ++++ ++E E+
Sbjct: 1229 SLEEEVSILNRQVLEKEGES 1248
Score = 44.7 bits (104), Expect = 4e-04
Identities = 71/341 (20%), Positives = 136/341 (39%), Gaps = 39/341 (11%)
Query: 584 QELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLR 643
QEL QQ ++ L+ LQ E +G+ ++ E+ + + Q L
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQ-----QQEQASQGLRHQV----EQLSSSLKQKEQQLKE 569
Query: 644 SALRRLALR---GNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALE 700
A ++ A R LAT + R + + L++ ALE+ + L+ Q QL A E
Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629
Query: 701 ARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQ---ALLVHARNAAT 757
AR + S + + ++ L + L E + Q + + + L + A
Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE 689
Query: 758 KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQG 817
K R D + ++A ES+ VT + + + + ++R + LK
Sbjct: 690 KERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADAL-----EEQQRCISELKAETR 744
Query: 818 ERMENYKLRKKQELSNPSSGSR-------TAGGAHETSQAVHQRML-----------SQQ 859
+E +K R+++EL +G + G AH+ V +R L S+
Sbjct: 745 SLVEQHK-RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC 803
Query: 860 KRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
++ + + ++ +QQ++A + + QL T +E E+
Sbjct: 804 EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK 844
Score = 40.4 bits (93), Expect = 0.008
Identities = 56/263 (21%), Positives = 108/263 (41%), Gaps = 36/263 (13%)
Query: 700 EARVLEEASRLEEEAQQ-----TRLQLQQRLLAEA-QEVGQLLQQHMECAIGQALLVHAR 753
EA++L E EEE QQ T LQ L++A +E+ Q Q H G L
Sbjct: 447 EAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAH-----GARLTAQVA 501
Query: 754 NAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEE--RKLQH 811
+ + + T + A ++ AG+ + + Q+ + ++ E+ + L+H
Sbjct: 502 SLTS----------ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRH 551
Query: 812 -----LKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQF 866
+L+ + + ++ +KQE + + A A E ++ +R + ++ L
Sbjct: 552 QVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ--LEAL 609
Query: 867 PVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ------NFISELAALARVPLAESKLL 920
+ +L QQQ V + +T + +A++ + EL A E
Sbjct: 610 EKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEA 669
Query: 921 PAKRGLLEKPLRTKRKKPLPQER 943
A+ LE LR++++K +ER
Sbjct: 670 QAQVAELELQLRSEQQKATEKER 692
>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
Length = 1133
Score = 49.7 bits (117), Expect = 1e-05
Identities = 137/613 (22%), Positives = 243/613 (39%), Gaps = 70/613 (11%)
Query: 337 SKARQLMMTLT--ERMIAAE-GLLCDSQELQALDALERTMGRAHMAKVIEFLKLQ-VQEE 392
S AR L+ + ++++AA+ L C ELQA + L A + + L+L+ Q E
Sbjct: 549 SLARSLLPSTEYQKQLLAAQVQLQCSPAELQA-ELLHSQARLAELEAQVRKLELERAQHE 607
Query: 393 TRCRLAAISH--GLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTA 450
H LEL+ + + E Q+ + +E E S ++ + ++ A
Sbjct: 608 LLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQA 667
Query: 451 SLAHQVEGTAKLT-LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEEN 509
+ +L +AQE++Q A E L+R +L++ D E +
Sbjct: 668 RAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLK-DREVDAA 726
Query: 510 VRATEAVVALCQ-----ELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQEN 564
AT +L E + S++ V+A L T L + D + +QE
Sbjct: 727 TSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERE-LGIRQRDEQLRALQER 785
Query: 565 AAWQLGKSNRFRRQQWKLF----------QELLEQDQQVWMEECALSSVLQTHLREDHEG 614
Q R +Q ++ LLEQ++ E + + +Q L E +
Sbjct: 786 LGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKV 845
Query: 615 TIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL 674
T + + L + + + ++L+ R L Q +LS ++ E
Sbjct: 846 TAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKER---AER 902
Query: 675 REQRALE-----QGSSQCLDEHQWQL------LRALEARVLEEASRLEEEAQQTRLQLQQ 723
+RAL+ +G+ L + Q +L LRA E ++ E + LE+E Q+ RL+ ++
Sbjct: 903 EAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLE-KE 961
Query: 724 RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTS 783
R+ A A V +L + +E + +K ++ ++ +R L EA V +
Sbjct: 962 RINATALRV-KLRAEEVE-------------SMSKVASEKYEEGERALREAQ----QVQA 1003
Query: 784 AGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGG 843
+RL QA QQ R+ + + +HL Q +R++ + R+ S R G
Sbjct: 1004 EQQARL-QAVQQQQERLRKQEQHMHQEHLSLAQ-QRLQLDRARQDLPSSLVGLFPRAQGP 1061
Query: 844 AHETSQAV-----HQRMLSQQKRFLAQFPVHQQMRL----HAQQQQAGVMDLLEAQLETQ 894
A + A+ R SQ L P+H RL H +Q ++ + LET
Sbjct: 1062 AASSQSALMPPAPTTRWCSQPPTGLDPSPLHLHARLALLRHMAEQDRDFLENEQFFLET- 1120
Query: 895 LQEAEQNFISELA 907
L++ N S A
Sbjct: 1121 LKKGSYNLTSHSA 1133
Score = 40.0 bits (92), Expect = 0.011
Identities = 57/246 (23%), Positives = 98/246 (39%), Gaps = 25/246 (10%)
Query: 699 LEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLV---HARNA 755
L AR L + E+ + Q Q+RL A AQE Q +++ E L + H
Sbjct: 653 LSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQL 712
Query: 756 ATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDH----EERKLQH 811
KDR+ T + S+ + + + ++ R+ H +ER+L
Sbjct: 713 QRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQEREL-- 770
Query: 812 LKTLQGERMENYKLRKKQE-LSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQ 870
G R + +LR QE L + + L++Q R L Q +
Sbjct: 771 -----GIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQ----E 821
Query: 871 QMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKP 930
+ R+ A+Q +A + ++ LE Q + Q E A L R A+S LL ++ ++ K
Sbjct: 822 RWRVTAEQSKA---ESMQRALEEQRKVTAQQMAMERAELER---AKSALLEEQKSVMLKC 875
Query: 931 LRTKRK 936
+R+
Sbjct: 876 GEERRR 881
>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
Length = 1154
Score = 49.3 bits (116), Expect = 2e-05
Identities = 137/661 (20%), Positives = 259/661 (39%), Gaps = 126/661 (19%)
Query: 228 LRQEKHMMF--IQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEK----------- 274
+ QE H+ IQ + D + +SD Q+ L + + +LE++E+
Sbjct: 139 IEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIAS 198
Query: 275 -GLQVKLSNTEMSGA-GDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQF 332
++++ ++E SG+ G S+Y L + ++ RE L + A + +++ L D
Sbjct: 199 LRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLE 258
Query: 333 KCSSSKARQLMMTLTERMIAAEGLLCDSQELQA--LDALERTMGRAHMAKVIEFLKLQVQ 390
+ +A TER + ++ L S E Q +D LE + + + + Q+
Sbjct: 259 SERTQRA-------TERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMH 311
Query: 391 ------EETRCRLAAISHGLELLAGEGK-----LSGRQKEELLTQQHKAFWQEAERFSRE 439
+E C L + H ++ E + L Q E L Q + Q E SR
Sbjct: 312 GMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRL 371
Query: 440 FVQRGK---------DLVTASLAHQVE----GTAKLTLAQEEEQRSFLAEAQP------- 479
+ K +L+ L Q E K TL + + ++ L Q
Sbjct: 372 CTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQN 431
Query: 480 -TADPEKFLEAFHEVLERQRLMQCDLE---------EEENVRATEAVVAL--CQELYFST 527
T + EK LE ++ E + + +L+ +E N + TE L ++LY ++
Sbjct: 432 VTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQAS 491
Query: 528 VDTFQK--------FVDALFLQ----------TLPGMTGLPPEECDYLRQEVQENAAWQL 569
D ++ D L Q +P G +CD L + E
Sbjct: 492 KDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTE------ 545
Query: 570 GKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLR-EDHEGTIRGVLGRLGGLTE 628
++++K Q+ + Q Q ME+C L L+ R ++ +G ++ L RL L
Sbjct: 546 ------LQEKYKASQKEMGQLQ---MEQCEL---LEDQRRMQEEQGQLQEELHRL-TLPL 592
Query: 629 ESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQE----LREQRALEQGS 684
+ +L+ +LL + L L L L Q +K L+Q L+EQ + +
Sbjct: 593 PKSGLLLKSQELLTK--LEDLC----ELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEEL 646
Query: 685 SQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAI 744
+ + H ++L + L ++S+ Q L Q + L + GQ Q+ ++
Sbjct: 647 RRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQ 706
Query: 745 GQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDH 804
G+ L + R + + D + L E ++ + V S + +++Y + G ++ +
Sbjct: 707 GRLL---------EERKRLQADLQLCLEE--MQLLQVQSPSIKMSLESYGKSYGSMVPSN 755
Query: 805 E 805
E
Sbjct: 756 E 756
Score = 36.6 bits (83), Expect = 0.12
Identities = 132/598 (22%), Positives = 232/598 (38%), Gaps = 108/598 (18%)
Query: 391 EETRCRLAAISHGLEL---LAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDL 447
EE R ++ + LE LAG+ + + + LL + A Q+AE F+++ Q +L
Sbjct: 59 EELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGEL 118
Query: 448 VT-----ASLAHQVEGTAK-----LTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQ 497
+ + L H+ E K L LAQ E Q A + E + + E L R
Sbjct: 119 RSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCR- 177
Query: 498 RLMQCDLEEEENVRA--TEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECD 555
MQ +LE+ E +R + +L E+ + + +L L G+ EE
Sbjct: 178 --MQNELEDMERIRGDYEMEIASLRAEMEMKSSEP----SGSLGLSDYSGL----QEELQ 227
Query: 556 YLR-------------QEVQENAAWQLG--KSNRFRR--QQWKLFQEL------LEQDQQ 592
LR QE + QL +S R +R ++W Q L + +
Sbjct: 228 ELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEM 287
Query: 593 VWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRL--- 649
++E +L+ LR D E + G+ + L E LQ H + RRL
Sbjct: 288 DFLEPDPEMQLLRQQLR-DAEEQMHGMKNKCQELCCELEE--LQHHRQVSEEEQRRLQRE 344
Query: 650 -------ALRGNALATLTQ-MRLSGKKHLLQELREQRALEQG---SSQCLDEHQWQLLRA 698
LR ++TQ L + LQ+ + EQ Q + + + L+
Sbjct: 345 LKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKV 404
Query: 699 LEARVLEEASRLEEEAQQTRLQLQ-QRLLAEAQ---EVGQLLQQHMECAIGQALLVHARN 754
+++ ++E S E + +L LQ Q + E + E Q LQ+ ++C +A L H R+
Sbjct: 405 MKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQC--HEAELQHLRD 462
Query: 755 AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKT 814
+ + D + T A + + Q Y + +D ER+
Sbjct: 463 TVASFKESNEKDTE-------------THAQLQEMKQLY-----QASKDELERQKHMYDQ 504
Query: 815 LQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRL 874
L+ + + K+ + S+P + G + R+ Q+++
Sbjct: 505 LEQDLLLCQLELKELKASHPIPEDK--GKCANKCDTLLSRLTELQEKY------------ 550
Query: 875 HAQQQQAGVMDLLEAQL---ETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEK 929
A Q++ G + + + +L + ++QE + EL L +PL +S LL + LL K
Sbjct: 551 KASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLT-LPLPKSGLLLKSQELLTK 607
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 48.9 bits (115), Expect = 2e-05
Identities = 126/641 (19%), Positives = 261/641 (40%), Gaps = 83/641 (12%)
Query: 217 HLKDLLHL----DTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEEL 272
HL+ LL ++ LR+E H F L ++ E+ +S E+ L +L
Sbjct: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKAL---QTVIEMKDSKISSMERGLRDL 401
Query: 273 EKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNM-------EAFWKQMANIQ 325
E+ +Q+ SN +S E + +V + ++ + ++ + EA W+++
Sbjct: 402 EEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKA 461
Query: 326 HFL---VDQFKCSSSKARQLMMTLTERMIAAEGLLCDS-QELQAL-DALERTMGRAHMAK 380
L + Q K S+ ++ L ++ DS Q ++ L ++L RA + +
Sbjct: 462 AGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 521
Query: 381 V-IEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGR---QKEELLTQQHKAFWQEAERF 436
++ L+L+++E+ ++ +G +G K+ L ++ K + +
Sbjct: 522 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE 581
Query: 437 SREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLER 496
+ + R K+ +SL +V+ T + + L EA A+ E+ +E E +R
Sbjct: 582 NLQEQLRDKEKQMSSLKERVKSLQADT-TNTDTALTTLEEA--LAEKERTIERLKEQRDR 638
Query: 497 QRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDY 556
+ E++E + D ++K + L + L +E
Sbjct: 639 D-----EREKQEEI------------------DNYKKDLKDLKEKVSLLQGDLSEKEASL 675
Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTI 616
L +++E+A+ L S + + K + LEQ + EEC +++ L++ HE +
Sbjct: 676 L--DLKEHAS-SLASSGLKKDSRLKTLEIALEQKK----EECLK---MESQLKKAHEAAL 725
Query: 617 RG-----VLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLL 671
+ R+ L E TR + ++ + RL + + + K +
Sbjct: 726 EARASPEMSDRIQHLEREITR--YKDESSKAQAEVDRLL----EILKEVENEKNDKDKKI 779
Query: 672 QELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQE 731
EL E++ +Q +H+ Q+ + A++LEEA R E+ + QLQ L +
Sbjct: 780 AEL-ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR 838
Query: 732 VGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
+ +L +AL + A + +++ RT E VE + + V + ++
Sbjct: 839 IEEL---------EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE 889
Query: 792 AYYQQIGRIMEDHEERKLQHLKTLQGERMENYK--LRKKQE 830
+ ++ + E++ HL L+ ER ++ + L KQE
Sbjct: 890 SMKAKLSSTQQSLAEKE-THLTNLRAERRKHLEEVLEMKQE 929
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 48.9 bits (115), Expect = 2e-05
Identities = 90/396 (22%), Positives = 147/396 (37%), Gaps = 74/396 (18%)
Query: 642 LRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEA 701
LRS L + N L + S L EL ++R + +SQ LD
Sbjct: 1266 LRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDA----------- 1314
Query: 702 RVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRA 761
E A RL E + LQ Q L + EV ME + +A L+ A +
Sbjct: 1315 ---ETAERLRAEKEMKELQTQYDALKKQMEV-------MEMEVMEARLIRAAEINGEVDD 1364
Query: 762 KDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYY--------------QQIGRIMEDHEE- 806
D R E AV V T RL Q + +++G + D EE
Sbjct: 1365 DDAGGEWRLKYERAVREVDFTK---KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEES 1421
Query: 807 -RKLQHLKT---------------LQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQ- 849
R LQ LK L+G+++ N++L KKQ + AHE +Q
Sbjct: 1422 QRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQ-----AHEEAQR 1476
Query: 850 -AVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAA 908
+ + L ++K L + +L + LE +LQ+ + A+
Sbjct: 1477 EKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEAS 1536
Query: 909 LARVPL----AESKLLPAKRGLLEK----PLRTKRKKPLPQERGDLGVPNNEDLASGD-- 958
LA+V E+K+ + L E+ + + K L E + +++++ S D
Sbjct: 1537 LAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEE 1596
Query: 959 -QTSGSLSSKRLSQQESEAGDSGNSK-KMLKRRSNL 992
+ + K+L Q E + + K K+L+ + L
Sbjct: 1597 VEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKREL 1632
Score = 32.3 bits (72), Expect = 2.3
Identities = 124/562 (22%), Positives = 220/562 (39%), Gaps = 92/562 (16%)
Query: 252 KSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLI 311
++D E Q+ L + +K + L LQ +T++ G + + ++EKK+R + +L
Sbjct: 1415 QADSEESQRALQQLKKKCQRLTAELQ----DTKLHLEG--QQVRNHELEKKQRRFDSELS 1468
Query: 312 DNMEAFWK---QMANIQH----FLVDQFKCSSSKARQLM--MTLTERMIAAEGLLCDSQE 362
E + Q +Q L + F + M T+++++ E L D
Sbjct: 1469 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISS 1528
Query: 363 LQALDALERTMGRAHMAKVIEFL-----KLQVQEETRCRLAAISHGLELLAGEGKLSGRQ 417
++ D A +AKV + L K++ QEE A LE + KL
Sbjct: 1529 QESKD-------EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLE----QAKLRLEM 1577
Query: 418 KEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEA 477
+ E + Q H S+E R +++ A + Q + ++ + EEE
Sbjct: 1578 EMERMRQTH----------SKEMESRDEEVEEARQSCQKK-LKQMEVQLEEEYEDKQKVL 1626
Query: 478 QPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRA----TEAVVALCQELYFSTVDTFQK 533
+ + E L + + R+ D E E+ +R T+A++A Q
Sbjct: 1627 REKRELEGKLATLSDQVNRR-----DFESEKRLRKDLKRTKALLADAQ------------ 1669
Query: 534 FVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQV 593
L L L + E L+ +++E+ + + + R+ ++L Q +
Sbjct: 1670 ----LMLDHLKN-SAPSKREIAQLKNQLEESE-FTCAAAVKARKAMEVEIEDLHLQIDDI 1723
Query: 594 WMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRG 653
+ AL L RE +E + RL E+ +++ H + A R LA
Sbjct: 1724 AKAKTALEEQLSRLQREKNE-----IQNRLEEDQEDMNE-LMKKHKAAVAQASRDLAQIN 1777
Query: 654 NALATLTQMRLSGKK--HLLQELREQ-RALEQGS-SQCLDEHQWQLLRALEARVLEE--- 706
+ A L + ++ LQ L+ Q LEQ + L Q +R LE R+ E
Sbjct: 1778 DLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ 1837
Query: 707 -------ASRLEEEAQQTRLQLQQRLLAEAQEVGQ--LLQQHMECAIGQALLVHARNAAT 757
ASRL+E ++ + QR+ AE +E Q LQ+ + + + AR A
Sbjct: 1838 VKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLR-DTKEEMGELARKEAE 1896
Query: 758 KSRAKDRDDFKRTLMEAAVESV 779
SR K + +EAA +S+
Sbjct: 1897 ASRKKHELEMDLESLEAANQSL 1918
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 48.1 bits (113), Expect = 4e-05
Identities = 112/520 (21%), Positives = 211/520 (40%), Gaps = 76/520 (14%)
Query: 266 EKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQ 325
EK +EL+ LQV++ NT E L +KE+E S QL + + +Q+ Q
Sbjct: 891 EKTCKELKHQLQVQMENTL------KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944
Query: 326 HFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFL 385
+ L K + + +QL + E ++E Q+ + ++AL+ + A + K
Sbjct: 945 NTL----KQNEKEEQQLQGNINELKQSSE------QKKKQIEALQGELKIAVLQKTELEN 994
Query: 386 KLQVQ-EETRCRLAAISHGLELLAGEGKLS------------GRQKEELLTQQH-KAFWQ 431
KLQ Q + LAA + +L + S GR+ E L T+Q K+ +
Sbjct: 995 KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEE 1054
Query: 432 EAERFSREFVQRGKDLVTASLAHQVEGTAKLTL----AQEEEQRSFLAEAQPTADPEKFL 487
+ + + + + Q TAK TL A++E+Q +A EK L
Sbjct: 1055 KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
Query: 488 EAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVD-----ALFLQT 542
+ V E+ +L + EE R + + L +EL +++ ++ + L +Q
Sbjct: 1115 KEKELVNEKSKLAEI---EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171
Query: 543 LPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSS 602
+ G + D L+ V++ Q ++ ++++ +L +E +E++ ++ E
Sbjct: 1172 KLELQG----KADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEV 1227
Query: 603 VLQTHLREDHEGT--IRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLA--------LR 652
++ H + + T I + LG + +E +S+ RR++ LR
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKE------------WQSSQRRVSELEKQTDDLR 1275
Query: 653 GNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALE--ARVLEEASRL 710
G + + + + + L E+ +G + L +L R L+ ++E R
Sbjct: 1276 GE--IAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRE 1333
Query: 711 EEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLV 750
+ Q Q R AE EV Q M C G ++ V
Sbjct: 1334 NQSLQIKHTQALNRKWAEDNEV----QNCMACGKGFSVTV 1369
Score = 37.0 bits (84), Expect = 0.092
Identities = 163/797 (20%), Positives = 299/797 (37%), Gaps = 142/797 (17%)
Query: 298 DVEKKEREYSEQLID--NMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEG 355
D K E +++E+ + N++A Q L + S + ++ + L+E+ A +
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376
Query: 356 LLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLEL--------- 406
L + E++ + EF +LQ Q E + + HGL+L
Sbjct: 377 LKEELSEVET----------KYQHLKAEFKQLQQQREEKEQ-----HGLQLQSEINQLHS 421
Query: 407 --LAGE---GKLSGRQKEELLTQQHKAFWQEAE------RFSREFVQRGKDLVTAS--LA 453
L E G+ GR KE+ K +E + + SR ++ K+ VT S L
Sbjct: 422 KLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR-LEEQLKEKVTNSTELQ 480
Query: 454 HQVEGTAKLTLAQEEEQRSFLA---EAQ--------PTADPEKFLEAFHEVLERQRLMQC 502
HQ++ T + Q+ Q+S A EAQ D ++ ++ +L++ +
Sbjct: 481 HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
Query: 503 DLEEEEN-----VRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYL 557
LE+E ++A E A+ +L T Q+ V L + L + + + L
Sbjct: 541 LLEKEREDLYAKIQAGEGETAVLNQLQEKN-HTLQEQVTQL-TEKLKNQSESHKQAQENL 598
Query: 558 RQEVQENAAWQLGKSNRFRRQQW---KLFQELLEQDQQVWMEECALSSV----------- 603
+VQE A +R + +L +L E ++V + + +
Sbjct: 599 HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK 658
Query: 604 ------LQTHLR------EDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLAL 651
LQ HL +D + + + +L +T + Q H L S L+
Sbjct: 659 TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD--KQEHCSQLESHLKEYKE 716
Query: 652 RGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLE 711
+ +L T+ K L + E +A ++ + Q L + Q QL LE R E + +LE
Sbjct: 717 KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ-QRQLNTDLELRATELSKQLE 775
Query: 712 EEAQ---QTRLQLQQRL---------LAEAQEVGQLLQQHMECAIGQALLVHAR-NAATK 758
E + TRL LQ++ L + +E Q+L+Q E + + H N +
Sbjct: 776 MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ 835
Query: 759 SRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHE---------ERKL 809
+ + K EA + + +S++ + ++++ E+
Sbjct: 836 TTVTELQKVKME-KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894
Query: 810 QHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVH 869
+ LK +MEN L++++EL + A + Q L Q + L Q
Sbjct: 895 KELKHQLQVQMEN-TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 870 QQM-----------------RLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARV 912
+Q ++ A Q + + L + +LE +LQ+ ELA
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELA----- 1008
Query: 913 PLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQ 972
AE + + + EK T Q + D +E LA+ L+Q+
Sbjct: 1009 --AEKEKISVLQNNYEKSQET-----FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Query: 973 E--SEAGDSGNSKKMLK 987
+ S GN K+++
Sbjct: 1062 DLISNRNQIGNQNKLIQ 1078
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 48.1 bits (113), Expect = 4e-05
Identities = 131/688 (19%), Positives = 272/688 (39%), Gaps = 91/688 (13%)
Query: 253 SDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLID 312
+D ++ ++L + K+L++ L+ + + + + K E E ++ ++
Sbjct: 1945 TDAQIKNELLESEMKNLKKCVSELE------------EEKQQLVKEKTKVESEIRKEYLE 1992
Query: 313 NMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQA-LDALER 371
++ K+ N H A++L L E+ + L D Q + ALER
Sbjct: 1993 KIQGAQKEPGNKSH------------AKELQELLKEKQQEVKQLQKDCIRYQEKISALER 2040
Query: 372 TMGRAHMAKVIEFLKLQVQEE---TRCRLA-AISHG----LELLAGEGKLSGRQKEELLT 423
T+ K +EF++ + Q++ T+ LA A+ H EL + + L Q E
Sbjct: 2041 TV------KALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094
Query: 424 QQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADP 483
++ + ++E V+ L ++E + L +++ + L + +
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALR--REK 2152
Query: 484 EKFLEAFHEVLERQRLMQCDLEE-EENVRATEAVVALCQELYFSTVDTFQKFVDAL---- 538
E E+ ++++ +EN+ +T +A + S D + +D
Sbjct: 2153 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWE 2212
Query: 539 -----FLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQV 593
+Q+ L + C L+ ++++ + ++ K+ LE D+Q+
Sbjct: 2213 RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMS---------IHMEELKINISRLEHDKQI 2263
Query: 594 WMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVL---QGHDLLLRSALRRLA 650
W + LQ + + +G + +L +L E TR + Q L S L+ L
Sbjct: 2264 WESKAQTEVQLQQKVCDTLQGENKELLSQL-----EETRHLYHSSQNELAKLESELKSLK 2318
Query: 651 LRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLD--EHQWQLLRALEARVLEEAS 708
+ L+ + K +L +R+Q A Q S + E Q R L +R+ EE +
Sbjct: 2319 DQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEIN 2378
Query: 709 RLE----------EEAQQTRL-QLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAAT 757
E EEA Q + +L+Q+ E +E+ LL Q E + +++ N
Sbjct: 2379 MKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEE----ENIVLEEENKKA 2434
Query: 758 KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLK-TLQ 816
+ + +T+ + ++ + V + + + RI+ D+++ + +HL L+
Sbjct: 2435 VDKTNQLMETLKTIKKENIQQKAQLDSFV-KSMSSLQNDRDRIVGDYQQLEERHLSIILE 2493
Query: 817 GERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQF----PVHQQM 872
+++ + +L G R+ + A L Q + L Q Q+
Sbjct: 2494 KDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQ 2553
Query: 873 RLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
L Q QQ ++ A+LE +L+E+E+
Sbjct: 2554 LLEVQLQQNKELENKYAKLEEKLKESEE 2581
Score = 45.8 bits (107), Expect = 2e-04
Identities = 164/889 (18%), Positives = 332/889 (37%), Gaps = 147/889 (16%)
Query: 52 RQRTRHQKDDTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDECEPPSNSNIT 111
R+ + QKDD L + + ++ G R+ + +V+ S D + PS
Sbjct: 1202 REELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKL------PSTDQQE 1255
Query: 112 AFALKAKVIYPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSL---------- 161
+ + + P+ F+ + P L NL P P + +S+L
Sbjct: 1256 SCSSTPGLEEPL---FKATEQHHTQPVLESNL----CPDWPSHSEDASALQGGTSVAQIK 1308
Query: 162 GSLSQGEKDDCSSSSSVHSATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDL 221
L + E + V S TS+ L++ V E + + ++++ H ++
Sbjct: 1309 AQLKEIEAEKVELELKVSSTTSE---LTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365
Query: 222 LHLDTALRQEKHMMFIQIFKM-CLLDLLPKKKSDDELYQKILSKQEKDLEEL-----EKG 275
H ++ L+Q+ +QI + L +L PK DEL QK++SK+E+D+ L EK
Sbjct: 1366 -HAES-LQQKLESSQLQIAGLEHLRELQPKL---DEL-QKLISKKEEDVSYLSGQLSEKE 1419
Query: 276 LQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCS 335
+ TE+ D +E + +E+ E+ I ++ +M + ++ +
Sbjct: 1420 AALTKIQTEIIEQEDLIKALHTQLEMQAKEHDER-IKQLQVELCEMKQKPEEIGEESRAK 1478
Query: 336 SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
R+L L R A L +++ LQ E ++ R + ++ + L +
Sbjct: 1479 QQIQRKLQAALISRKEA----LKENKSLQE----ELSLARGTIERLTKSL-----ADVES 1525
Query: 396 RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQ 455
+++A + + + G L ++++L+T+ ++ + + + + +L
Sbjct: 1526 QVSAQNKEKDTVLGRLALLQEERDKLITEMDRSL------LENQSLSSSCESLKLALEGL 1579
Query: 456 VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEA 515
E KL E + S +AE+ + K L+ +E+L Q E E EA
Sbjct: 1580 TEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEIL-LQSYENVSNEAERIQHVVEA 1638
Query: 516 VVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRF 575
V QELY T +E + QE ++ K +F
Sbjct: 1639 VRQEKQELYGKLRSTEAN-----------------KKETEKQLQEAEQEMEEMKEKMRKF 1681
Query: 576 RRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVL 635
+ + + EL E++ + +R + G +E +L
Sbjct: 1682 AKSKQQKILELEEENDR-----------------------LRAEVHPAGDTAKECMETLL 1718
Query: 636 QGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQL 695
+ ++ L R+ + L+ Q +S K L +E+++ + HQ
Sbjct: 1719 SS-NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLK------------HQ--- 1762
Query: 696 LRALEARVLEEAS--RLEEEAQQTRLQLQ--QRLLAEAQEVGQLLQQHMECAIGQALLVH 751
+E V ++A+ E+ QT + + Q + E +E L
Sbjct: 1763 ---IEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAK 1819
Query: 752 ARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQH 811
+ N A D+ L + ++ + AG+ Q ++ + +E+ + L
Sbjct: 1820 SANPAVSKDFSSHDEINNYLQQ--IDQLKERIAGLEEEKQK-NKEFSQTLENEKNTLLSQ 1876
Query: 812 LKTLQGE---------RMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRF 862
+ T GE +M + ++ELS + T A E + +R+++Q
Sbjct: 1877 ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKET---AEEEKDDLEERLMNQLAEL 1933
Query: 863 LAQFPVHQQMRLHAQQQQAGVMDLLEAQLE------TQLQEAEQNFISE 905
+ Q AQ + +LLE++++ ++L+E +Q + E
Sbjct: 1934 NGSIGNYCQDVTDAQIKN----ELLESEMKNLKKCVSELEEEKQQLVKE 1978
Score = 42.4 bits (98), Expect = 0.002
Identities = 123/539 (22%), Positives = 215/539 (39%), Gaps = 89/539 (16%)
Query: 390 QEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQE---AERFSREFVQRGKD 446
QE+ + RLA E L E K RQK+ L Q+ +A +E A+ ++ K
Sbjct: 47 QEDVQERLAYA----EQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKA 102
Query: 447 LVTASLAHQVE------GTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRL- 499
+T SL +E GT T Q EEQ S + T + + + H++ E++ L
Sbjct: 103 KLT-SLNKYIEEMKAQGGTVLPTEPQSEEQLS-KHDKSSTEEEMEIEKIKHKLQEKEELI 160
Query: 500 --MQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYL 557
+Q L + + + ++ + E + Q+ + F+ TL L
Sbjct: 161 STLQAQLTQAQAEQPAQSSTEM--EEFVMMKQQLQEKEE--FISTLQAQ----------L 206
Query: 558 RQEVQENAAWQL--GKSNRFRRQ----QWKLFQELLEQDQQVWMEECALSSVLQTHLRED 611
Q E AA Q+ K RF Q + +L Q + + D + M++ VLQ L E+
Sbjct: 207 SQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKL--RVLQRKL-EE 263
Query: 612 HEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLL 671
HE ++ G + L +E T + + +L L+++ N L + K LL
Sbjct: 264 HEESLVGRAQVVDLLQQELTAA--EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILL 321
Query: 672 QELREQRALEQGSSQCLDEHQWQLLRA----------LEAR--VLEEASRLEEEA----- 714
+++ + A + S L E LL LE+R LE+ + E E
Sbjct: 322 EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHI 381
Query: 715 ---QQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTL 771
Q+T +LQ A + +LLQ E A+ A + + ++K+ F L
Sbjct: 382 LSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRL 441
Query: 772 ----MEAAVESVY--VTSAGVSRLVQAYYQQI-GRIMEDHEERKLQHLKTLQGERM--EN 822
E A ++ + V + G + + + R++E E+ L +++ E + EN
Sbjct: 442 PLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAEN 501
Query: 823 YKL-----------------RKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLA 864
KL R+ E+S ++ + A E+ Q V + SQ+ + L+
Sbjct: 502 EKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELS 560
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 47.8 bits (112), Expect = 5e-05
Identities = 92/489 (18%), Positives = 197/489 (40%), Gaps = 64/489 (13%)
Query: 248 LPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYS 307
L + ++EL+ ++ +QE+ + E+ +Q E + + + E+K RE
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQ------EWEEKIQEQEEKIREQEEKIREQE 334
Query: 308 EQLIDNMEAFWKQMANI--QHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQA 365
E++ E W++ + Q ++ + + + ++M E+M E ++ + +E
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE--K 392
Query: 366 LDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQ 425
+ LE M H + I + + QEE + R E + R++EE + +Q
Sbjct: 393 IRELEEKM---HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449
Query: 426 HKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEK 485
K W++ E+ H+ E +EEE+R Q + +
Sbjct: 450 EKKMWRQEEKI-----------------HEQEKI------REEEKR------QEQEEMWR 480
Query: 486 FLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPG 545
E HE E R + E+EE +R E V +E + ++ + ++ Q
Sbjct: 481 QEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKI 540
Query: 546 MTGLPPEECDYLRQEV---QENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSS 602
E+ + R+E ++ W+ K + W+ +++ EQ+++VW +E +
Sbjct: 541 R-----EQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIRE 595
Query: 603 VLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQM 662
Q R++ E + ++ E+ +Q + +R + +R T Q
Sbjct: 596 --QEEKRQEQEEKMWKQEEKIREQEEK-----IQEQEEKIREQEEK--IREQEEMTQEQE 646
Query: 663 RLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQ 722
G++ +E++ EQ + E + +R E ++ E+ ++ E Q+ +Q Q
Sbjct: 647 EKMGEQEEKMCEQEEKMQEQEETMWRQEEK---IREQEKKIREQEEKIRE--QEEMMQEQ 701
Query: 723 QRLLAEAQE 731
+ + E +E
Sbjct: 702 EEKMWEQEE 710
Score = 36.2 bits (82), Expect = 0.16
Identities = 31/140 (22%), Positives = 57/140 (40%), Gaps = 14/140 (10%)
Query: 300 EKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCD 359
E+K RE E+ + E WKQ I+ + + + E++ E + +
Sbjct: 590 EEKIREQEEKRQEQEEKMWKQEEKIR------------EQEEKIQEQEEKIREQEEKIRE 637
Query: 360 SQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKE 419
+E+ E MG + K+Q QEET R E E + R++E
Sbjct: 638 QEEMT--QEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQE 695
Query: 420 ELLTQQHKAFWQEAERFSRE 439
E++ +Q + W++ E+ +
Sbjct: 696 EMMQEQEEKMWEQEEKMCEQ 715
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 47.8 bits (112), Expect = 5e-05
Identities = 74/351 (21%), Positives = 147/351 (41%), Gaps = 38/351 (10%)
Query: 259 QKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFW 318
+K L +QEK+L E EK L+ + E + + + E+K RE E++ E W
Sbjct: 320 EKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379
Query: 319 KQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHM 378
+Q ++ + Q M ERM + L + +E E+ +
Sbjct: 380 EQEKQMR------------EQEQKMRDQEERMWEQDERLREKEERMR----EQEKMWEQV 423
Query: 379 AKVIEFLKLQVQE-ETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFS 437
K+ E K+Q QE +TR + + + E K+ R++EE + +Q + ++ E
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKM--REEEETMREQEEKMQKQEENM- 480
Query: 438 REFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQ 497
+ Q K+ L Q E + QE+E++ + E + D E+ ++ ++
Sbjct: 481 --WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE-EKIRDQEEMWGQEKKMWRQE 537
Query: 498 RLMQCD---LEEEENVR--------ATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGM 546
++ + + E+EE +R E + QE T D +K + + +
Sbjct: 538 KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE---ERMRER 594
Query: 547 TGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEE 597
EE + +R++ +E Q K + W+ +++ EQ++++W +E
Sbjct: 595 EKKMREEEEMMREQ-EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644
Score = 38.1 bits (87), Expect = 0.041
Identities = 62/292 (21%), Positives = 114/292 (39%), Gaps = 44/292 (15%)
Query: 228 LRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSG 287
+R+++ M+ Q KM D K +E +K +QEK + E+ ++ + E
Sbjct: 539 MREQEDQMWEQEEKM--RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
Query: 288 AGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLT 347
E + + E+K +E E++ + E W+Q +Q + + M
Sbjct: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQ------------EQEEKMWEQE 644
Query: 348 ERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELL 407
E+M E + + Q L K+ E K+Q QE ++
Sbjct: 645 EKMWEQEEKMWEQQRLP-----------EQKEKLWEHEKMQEQE-------------KMQ 680
Query: 408 AGEGKLSGRQKEELLTQ-QHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQ 466
E K+ ++K E TQ Q K W + + E ++ + + E K+ Q
Sbjct: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKM---Q 737
Query: 467 EEEQRSFLAEAQPTADPEKFLEAFHEVLERQRL--MQCDLEEEENVRATEAV 516
E+E++ E + EK E ++ E+QRL + L E E ++ E +
Sbjct: 738 EQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKI 789
Score = 37.0 bits (84), Expect = 0.092
Identities = 67/357 (18%), Positives = 149/357 (41%), Gaps = 35/357 (9%)
Query: 259 QKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFW 318
+K + +QEK + E+ +Q + E E T+ + E+K ++ E + + E W
Sbjct: 429 EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEW 488
Query: 319 KQ--MANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRA 376
+Q + + L +Q K M E++ E + D +E+ E+ M R
Sbjct: 489 QQQRLPEQKEKLWEQEK---------MQEQEEKIWEQEEKIRDQEEMWGQ---EKKMWRQ 536
Query: 377 HMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQK-----------EELLTQQ 425
+ E + +E+ R + + E + E K ++K EE + ++
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERM--EKKTQEQEKKTWDQEEKMREEERMRER 594
Query: 426 HKAFWQEAE--RFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADP 483
K +E E R E +Q ++ + E K+ QE+E++ + E +
Sbjct: 595 EKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKM---QEQEEKMWEQEEKMWEQE 651
Query: 484 EKFLEAFHEVLERQRLMQCD-LEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQT 542
EK E ++++L + + ++E+E ++ E + +++ T + +K D ++
Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMRE 711
Query: 543 LPGMTGLPPE--ECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEE 597
M + E + + +E +E Q K + W+ +++ EQ++++W ++
Sbjct: 712 EESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 47.4 bits (111), Expect = 7e-05
Identities = 132/692 (19%), Positives = 265/692 (38%), Gaps = 77/692 (11%)
Query: 248 LPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSN-TEMSGAGDSEYITLADVEKKEREY 306
L ++S +L + +QE+D E+ + Q + + E E ++K +E
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317
Query: 307 SEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQAL 366
+ L + E ++ + F ++ + + L +R E L Q + L
Sbjct: 1318 KQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Query: 367 DALERTMGRAHMAKVI-EFLKLQVQE--------------ETRCRLAAISHGLELLAGEG 411
+ +R + K + E +L+ QE E +L+ + E
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 412 KLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT-----LAQ 466
++ +++E ++ + QE R RE Q ++ L H+ E K L +
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL-HRQERDRKFLEEEQQLRR 1496
Query: 467 EEEQRSFLAEAQPTADPE-KFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYF 525
+E R F + + +PE KFLE + L RQ+ + L+EE+ +R E Q
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEE-EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ---- 1551
Query: 526 STVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQE 585
D +KF E + LRQE +E + + +FR ++ K+ ++
Sbjct: 1552 ---DRDRKF-----------------REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591
Query: 586 -----LLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDL 640
+E +QQ+ +E Q LR++ + R L E+ +
Sbjct: 1592 EQERKFMEDEQQLRRQEG------QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF 1645
Query: 641 LLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLR-AL 699
L R R L + ++ LLQE EQ+ Q + E + QL R
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQER 1705
Query: 700 EARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKS 759
E + L+E +L + + + + +++L E ++ QL +Q I + + +
Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQ-EQLRRQERYRKILEEEQLRPEREEQQL 1764
Query: 760 RAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGER 819
R ++RD ++ E + S+ +++ ++ ++ EE++L+ + R
Sbjct: 1765 RRQERD--RKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYR 1822
Query: 820 MENYKL-------RKKQELSNP-------SSGSRTAGGAHETSQAVHQRMLSQQKRFLAQ 865
E +L R +QE ++ ++ E Q Q+ +++R L +
Sbjct: 1823 WEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882
Query: 866 FPVHQQMRLHAQQQQAGVMDLLEAQLETQLQE 897
+ +Q + + +Q G + E + +L E
Sbjct: 1883 EHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914
Score = 43.5 bits (101), Expect = 0.001
Identities = 47/242 (19%), Positives = 102/242 (42%), Gaps = 17/242 (7%)
Query: 659 LTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTR 718
L ++R G++ Q+ RE+ + Q +E +W R E + +E +L+EE Q +
Sbjct: 215 LLELRRKGREEKQQQRRER---QDRVFQEEEEKEW---RKRETVLRKEEEKLQEEEPQRQ 268
Query: 719 LQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVES 778
+LQ+ E +++ +L +Q + + R + + +++ +R E E
Sbjct: 269 RELQE----EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324
Query: 779 VYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGS 838
R Q ++ ++ + EER+ Q L+ Q E +LR++QE
Sbjct: 325 Q-------ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377
Query: 839 RTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEA 898
R Q ++ L ++++ + + ++ +L +QQ L Q E + ++
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 899 EQ 900
+
Sbjct: 438 HE 439
Score = 42.7 bits (99), Expect = 0.002
Identities = 114/537 (21%), Positives = 206/537 (38%), Gaps = 86/537 (16%)
Query: 388 QVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAF---WQEAERFSREFVQRG 444
Q QEE R R + EL E + + RQ++E +Q + F WQ E+ +RG
Sbjct: 733 QEQEEKRRRRES-----ELQWQEEERAHRQQQE--EEQRRDFTWQWQAEEKS-----ERG 780
Query: 445 KDLVTAS--LAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEK----------FLEAFHE 492
+ ++A L Q E + Q+ EQR FL E + + FLE +
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQR-FLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 493 VLERQRLMQCDLEE----EENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTG 548
+ R+R Q EE E+ R Q+ + + ++ L+ + P +
Sbjct: 840 LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK--PALQE 897
Query: 549 LPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHL 608
+E L++E +E L + R +R++ + ++ E++Q EE L +
Sbjct: 898 QLRKEQQLLQEEEEE-----LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952
Query: 609 REDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKK 668
R++ E R + + + LL +R + ++
Sbjct: 953 RQERERQYR-----------KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 669 HLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAE 728
LL+E RE+R ++ Q + + Q EE L EE ++ RLQ ++R E
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQ---------QEEEQLLREEREKRRLQERERQYRE 1052
Query: 729 AQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSR 788
+E LQQ E +G+ R + K+ + ++ E + R
Sbjct: 1053 EEE----LQQEEEQLLGEERETRRRQELERQYRKEEE------LQQEEEQLLREEPEKRR 1102
Query: 789 LVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETS 848
Q+ R + EE + + + L+ ER + R++QEL E
Sbjct: 1103 -----RQERERQCREEEELQQEEEQLLREER----EKRRRQELERQYR-------EEEEV 1146
Query: 849 QAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISE 905
Q +++L ++ + + +Q R + QQ LL + E + QE E+ + E
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQE-EEQLLREEQEKRRQERERQYREE 1202
Score = 39.7 bits (91), Expect = 0.014
Identities = 98/477 (20%), Positives = 184/477 (38%), Gaps = 78/477 (16%)
Query: 466 QEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYF 525
QEEE++ + E+ L+ E +RQR +Q EEEE +R E QEL
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQ--EEEPQRQRELQ---EEEEQLRKLER-----QELRR 288
Query: 526 STVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQE 585
+ Q+ Q L L ++ + R++ +E Q + + R++ +L +E
Sbjct: 289 ERQEEEQQ------QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342
Query: 586 LLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSA 645
E+ +Q E Q RE E L R E+ R
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQEEERREQQLRR-----EQQLR------------- 384
Query: 646 LRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLE 705
R L Q+R + Q+LR ++ L + + QL R + R +
Sbjct: 385 ------REQQLRREQQLRREQQLRREQQLRREQQLRR---------EQQLRREQQLRREQ 429
Query: 706 EASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRD 765
E R E++ +Q R + QRL E +E L++ E H + + +D++
Sbjct: 430 EEERHEQKHEQERRE--QRLKREQEERRDWLKREEETER------HEQERRKQQLKRDQE 481
Query: 766 DFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKL 825
+ +R E R Q +Q ++ + EER+ Q LK + E +L
Sbjct: 482 EERRERWLKLEEEE-------RREQQERREQ--QLRREQEERREQRLKRQEEEERLQQRL 532
Query: 826 RKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMD 885
R +Q+L E + Q + ++++ L Q Q+++ ++++ ++
Sbjct: 533 RSEQQL------------RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580
Query: 886 LLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQE 942
E + + +L+ ++ + + V E + +R E+P +R++ L E
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE 637
Score = 37.7 bits (86), Expect = 0.054
Identities = 79/359 (22%), Positives = 141/359 (39%), Gaps = 31/359 (8%)
Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTI 616
LR+E Q QL + + RR+Q ++ L ++QQ+ E+ + + HE
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442
Query: 617 RGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELRE 676
R RL EE D L R + L + + ++ +L E
Sbjct: 443 REQ--RLKREQEER-------RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 677 QRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQ-QTRLQLQQRLLAEAQEVG-Q 734
+ EQ + + QL R E R + R EEE + Q RL+ +Q+L E +E Q
Sbjct: 494 EERREQQ-----ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 735 LLQQHMECAIGQALLVHA--------RNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGV 786
LL++ E + Q R+ K + R + E +E + V
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ-RLKREEV 607
Query: 787 SRLVQAYY-QQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
RL Q +Q + E EER+ Q LK+ + E +LR++Q+ R
Sbjct: 608 ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR-----E 662
Query: 846 ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFIS 904
E + + QR+ + + + + ++ + A+++ + + QLE++ + S
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Score = 34.3 bits (77), Expect = 0.60
Identities = 110/563 (19%), Positives = 203/563 (36%), Gaps = 102/563 (18%)
Query: 416 RQKEELLTQQHKAFWQEAERFSREFVQRG--KDLVTASLAHQVEGTAKLTLAQEEEQRSF 473
R++E+L ++ + +E E+ R+ +R KD Q+ G ++E ++ +
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 474 LAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQK 533
E + + E+ L EE E R E E + D Q+
Sbjct: 991 REEEELQQEEEQLLR----------------EEREKRRRQE------WERQYRKKDELQQ 1028
Query: 534 FVDALFLQTLPGMTGLPPEECDYLRQE-VQENAAWQLGKSNRFRRQQ-----WKLFQELL 587
+ L L+ L E Y +E +Q+ LG+ RR+Q ++ +EL
Sbjct: 1029 EEEQL-LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087
Query: 588 EQDQQVWMEE------------CALSSVLQTH----LREDHEGTIRGVLGRLGGLTEEST 631
++++Q+ EE C LQ LRE+ E R L R EE
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE-- 1145
Query: 632 RCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEH 691
V Q + LLR + ++ L ++ RE+ L+Q Q L E
Sbjct: 1146 --VQQEEEQLLREEPEKRR----------------RQELERQYREEEELQQEEEQLLREE 1187
Query: 692 QWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVH 751
Q E R E + EE + R + +QR E Q Q E
Sbjct: 1188 Q-------EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA------ 1234
Query: 752 ARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQH 811
R+ + ++ + F R L ++ + + Q + ++ + +ER +
Sbjct: 1235 VRDNKVYCKGRENEQF-RQLEDSQLRD------------RQSQQDLQHLLGEQQERDREQ 1281
Query: 812 LKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQ 871
+ +R ++ ++ E R + E Q + + +++R ++
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341
Query: 872 MRLHAQQQQAGV----MDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGL- 926
+L ++++ + D + E + QE + F+ E L R E K L ++ L
Sbjct: 1342 EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE-RERKFLKEEQQLR 1400
Query: 927 ---LEKPLRTKRKKPLPQERGDL 946
E+ LR R + +E L
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQL 1423
Score = 30.8 bits (68), Expect = 6.6
Identities = 46/271 (16%), Positives = 107/271 (39%), Gaps = 9/271 (3%)
Query: 672 QELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQE 731
++ R QR + Q L+E + R ++ EE L+E+ ++ R Q Q+R +
Sbjct: 818 EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ 877
Query: 732 VGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
+ + ++ + L + ++ ++ +R E +Q
Sbjct: 878 LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQ 937
Query: 792 AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAV 851
+Q+ R EER+ + + + + ++ KL++K+E + E
Sbjct: 938 QEEEQLLR-----EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE 992
Query: 852 HQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALAR 911
+ + ++++ L + ++ R ++Q D L+ + E L+E + L R
Sbjct: 993 EEELQQEEEQLLRE--EREKRRRQEWERQYRKKDELQQEEEQLLREEREK--RRLQERER 1048
Query: 912 VPLAESKLLPAKRGLLEKPLRTKRKKPLPQE 942
E +L + LL + T+R++ L ++
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQELERQ 1079
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 47.4 bits (111), Expect = 7e-05
Identities = 178/873 (20%), Positives = 342/873 (39%), Gaps = 124/873 (14%)
Query: 199 PEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELY 258
P +S + L +LH + L D R E + + L D ++++ +E
Sbjct: 511 PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQL 570
Query: 259 QKILSKQEKDL---EELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNME 315
Q++ K + + E+ ++ +Q S E+ S V +++ E Q + ++
Sbjct: 571 QRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQ 630
Query: 316 AFWKQMANIQHFLVDQFKCSSSKA-----------RQLMMTLTERMIAAEGLLCDSQELQ 364
A +++ + L ++ + + RQL +R + A+ L+ + +E
Sbjct: 631 AAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELV-EVREAL 689
Query: 365 ALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQ 424
+ L+R M +A A+V E L T+ +GR + EL
Sbjct: 690 SRATLQRDMLQAEKAEVAEAL-------TKAE-----------------AGRVELELSMT 725
Query: 425 QHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPE 484
+ +A E S + + SLA +L +AQ EE++S L Q A+ E
Sbjct: 726 KLRA-----EEASLQDSLSKLSALNESLAQDKLDLNRL-VAQLEEEKSALQGRQRQAEQE 779
Query: 485 KFLEAFHEVLERQRLMQCDLEEE---ENVRATEAVVALCQELYFSTVDTFQKFVDALF-- 539
+ E++RL + LE+E + + + V QE + T + L
Sbjct: 780 ATVARE----EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ 835
Query: 540 LQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECA 599
L L +E + R+E Q Q+ R R++ L +E Q+ E
Sbjct: 836 LAQLSRQLSGREQELEQARREAQR----QVEALERAAREKEALAKEHAGLAVQLVAAERE 891
Query: 600 LSSVLQ--THLR---EDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSAL---RRLAL 651
++ + T LR E EG++ V +L L + +G LLL L
Sbjct: 892 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
Query: 652 RGNALAT----------LTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEA 701
R +AT + Q + ++ LREQRA + Q L + R LEA
Sbjct: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011
Query: 702 RVLEEASRLEEEAQQ--TRLQ------------LQQR-----LLAEAQEVGQL-LQQHME 741
+ S+L+ E ++ RL+ LQQ LLAE+++ L L++ +
Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEK 1071
Query: 742 CAIGQALLVHARNAAT--------KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAY 793
A+ + L+ + AT K A+ R + R+ + A + A A+
Sbjct: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH 1131
Query: 794 YQQIGRIMEDHEE---------RKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGA 844
Q++ R+ E + R+ + L+T Q +E+ + ++EL R +
Sbjct: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRT-QLRLLEDARDGLRRELLEAQRKLRES--- 1187
Query: 845 HETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFIS 904
+ + V ++ + +R L + ++ + ++ + E++ L+ A ++
Sbjct: 1188 -QEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESE-RISLKLANEDKEQ 1245
Query: 905 ELAALARVPLAESKLLPAKR-GLLE-KPLRTKRKKPLPQERGDLGVPNNEDLASGDQTS- 961
+LA L A K R GL E + R + ++ L + R + + ++E+ G + +
Sbjct: 1246 KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE 1305
Query: 962 --GSLSSKRLSQQESEAGDSGNSKKMLKRRSNL 992
G L+ +++ES G +++LK ++L
Sbjct: 1306 LQGRLALGERAEKESRRETLGLRQRLLKGEASL 1338
Score = 31.6 bits (70), Expect = 3.9
Identities = 130/541 (24%), Positives = 213/541 (39%), Gaps = 108/541 (19%)
Query: 399 AISHGLELLAGEGKLSGRQKEELLTQQHKAFWQ----EAERFSREFVQRGKDLVTA---- 450
A+ L E + + R+++EL TQ Q EAER S R + L A
Sbjct: 1506 AVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSA--TSRARQLQKAVAES 1563
Query: 451 -----SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE 505
S+ ++ G QEE R E + T D LE + E + ++ E
Sbjct: 1564 EEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESE--LRASQE 1621
Query: 506 EEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENA 565
+ ++A E + + +D + L LQ L E+Q +
Sbjct: 1622 KISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRS------------LEGELQRS- 1668
Query: 566 AWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLR---------EDHEGTI 616
+LG S+R Q + Q+ ++ Q+ + + LQ + E+ EG +
Sbjct: 1669 --RLGLSDR--EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGAL 1724
Query: 617 RGVLGRLGGLTE---ESTRCVLQGHD--LLLRSALRRLALRGNALATLTQMRLSGKKHLL 671
R ++ GLTE +S+ + D L L+ AL L Q RL + L
Sbjct: 1725 RD---KVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVL----QERLDAARQAL 1777
Query: 672 QELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQE 731
E R+Q S L E Q Q LR A + E R+E E Q Q+
Sbjct: 1778 SEARKQ-------SSSLGE-QVQTLRGEVADL--ELQRVEAEGQ-------------LQQ 1814
Query: 732 VGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
+ ++L+Q E G+A AA + K +D+ R L++ + S+ A + +
Sbjct: 1815 LREVLRQRQE---GEA-------AALNTVQKLQDE--RRLLQERLGSLQRALAQL----E 1858
Query: 792 AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGS----RTAGGAH-E 846
A +++ R E+ ++ +TL +++E KLR ++ S+ RT GA E
Sbjct: 1859 AEKREVERSALRLEKDRVALRRTL--DKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELE 1916
Query: 847 TSQAVHQ-RMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLE------AQLETQLQEAE 899
++A Q + L Q L Q Q+ + AQQQQ + +E AQ E L+ E
Sbjct: 1917 LAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARE 1976
Query: 900 Q 900
+
Sbjct: 1977 R 1977
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 47.0 bits (110), Expect = 9e-05
Identities = 99/388 (25%), Positives = 163/388 (42%), Gaps = 59/388 (15%)
Query: 416 RQKEELLTQQHKAFWQEAERFSREFVQRGKD----LVTASLAHQVEGTAKLTLAQEEEQR 471
R+ EE+ + F ++ F + VQ KD L AH+ E +L +Q++
Sbjct: 36 REVEEI----RRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRRE-IQELLKSQQDHSA 90
Query: 472 SFLAEAQPTADPEKF-LEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDT 530
S + + + +E+ +++LE RL + L E+ + +A Q Y +DT
Sbjct: 91 SVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKA-----QSFYERELDT 145
Query: 531 FQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LE 588
++ LF T + +E D LR+E Q G+ R+ KL EL ++
Sbjct: 146 LKR--SQLF--TAESLQASKEKEAD-LRKEFQ-------GQEAILRKTIGKLKTELQMVQ 193
Query: 589 QDQQVWMEEC-----ALS------SVLQTHLREDHEGTI------RGVLGRLGGLTEEST 631
+ +++C AL+ VLQ L + EG + + V L E
Sbjct: 194 DEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARE--- 250
Query: 632 RCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKK----HLLQELREQRALEQGSSQC 687
R Q DL+L+++ + +T L +K L +L E+RA + +Q
Sbjct: 251 RLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQS 310
Query: 688 LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ-LQQRLLAEAQEVGQLLQQHMECAIGQ 746
LDE Q Q + LE +V EA R ++E + L+ LQ RL +EV QL + H +
Sbjct: 311 LDEEQKQQILELEKKV-NEAKRTQQEYYERELKNLQSRL---EEEVTQLNEAHSKTLEEL 366
Query: 747 ALLVHARNAATKSRA-KDRDDFKRTLME 773
A H A S A +D+ + L E
Sbjct: 367 AWKHHMAIEAVHSNAIRDKKKLQMDLEE 394
Score = 41.2 bits (95), Expect = 0.005
Identities = 110/556 (19%), Positives = 214/556 (38%), Gaps = 67/556 (12%)
Query: 260 KILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWK 319
++L KQ D +E E L K E A A E+ +++ S+ ++
Sbjct: 218 QVLQKQLDDAKEGEMALLSKHKEVESELA--------AARERLQQQASDLVLKASHIGML 269
Query: 320 QMANI-QHFLVDQFKCSSSKARQLMMTLTER--MIAAEGLLCDSQELQALDALERTMGRA 376
Q + Q + + S+ + + L E + ++ D ++ Q + LE+ + A
Sbjct: 270 QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEA 329
Query: 377 ------HMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFW 430
+ + ++ L+ +++EE A S LE LA + ++ + K
Sbjct: 330 KRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQ 389
Query: 431 QEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAF 490
+ E Q KD KL L +++ Q E +K A
Sbjct: 390 MDLEE------QHNKD--------------KLNLEEDKNQLQQELENLKEVLEDKLNTAN 429
Query: 491 HEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLP 550
E+ Q +++ + E+ + + E ++A Q+ + D+L +T + +
Sbjct: 430 QEIGHLQDMVR---KSEQGLGSAEGLIASLQDSQERLQNELDLTKDSL-KETKDALLNVE 485
Query: 551 PEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQV-WME----ECALSSVLQ 605
E L QE Q++ ++ +++ KL + + D ++ W E EC S L+
Sbjct: 486 GE----LEQERQQHE-----ETIAAMKEEEKLKVDKMAHDLEIKWTENLRQEC---SKLR 533
Query: 606 THLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLAL-RGNALATLTQMRL 664
LR HE + + +L L + + L +++L + N L+Q +
Sbjct: 534 EELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQT 593
Query: 665 SGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRL---QL 721
S ++ Q +E++ L Q + ++HQ + EA VL + EE+ ++ R L
Sbjct: 594 SLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 653
Query: 722 QQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYV 781
QQ+ AE Q L H E G + R + D+ K L E +
Sbjct: 654 QQKHSAELQS---LKDAHRESMEG--FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQ 708
Query: 782 TSAGVSRLVQAYYQQI 797
+A + L ++Q++
Sbjct: 709 HAAAIDLLRHNHHQEL 724
Score = 36.6 bits (83), Expect = 0.12
Identities = 88/404 (21%), Positives = 162/404 (40%), Gaps = 57/404 (14%)
Query: 134 SSNPSLHENLKQAVLPHQPV--EASPSSS------LGSLSQGEKDDCSSSSSVHSATSDD 185
S SL E KQ +L + EA + L +L +++ + + HS T ++
Sbjct: 306 SKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEE 365
Query: 186 RFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLD---TALRQEKHMMFIQIFKM 242
+ + + A + + + + H KD L+L+ L+QE ++ K
Sbjct: 366 -LAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQE-----LENLKE 419
Query: 243 CLLDLLPKKKSDDELYQKILSKQEK----------DLEELEKGLQVKLSNTEMSGAGDSE 292
L D L + Q ++ K E+ L++ ++ LQ +L T+ S +
Sbjct: 420 VLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKD 479
Query: 293 YITLADVE-KKEREYSEQLIDNMEAFWK-QMANIQHFL----VDQFKCSSSKARQLMMTL 346
+ + E ++ER+ E+ I M+ K ++ + H L + + SK R+ +
Sbjct: 480 ALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL--- 536
Query: 347 TERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLEL 406
R+ E +L L E+ R K +E L Q+ + + LE+
Sbjct: 537 --RLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQI--------SLLKQNLEI 586
Query: 407 LAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTAS-LAHQVEGTAKLTLA 465
+ + S +Q + TQ+ + QE E + QR K L A LA Q K
Sbjct: 587 QLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEK---- 642
Query: 466 QEEEQRSFLAEAQP--TADPEKFLEAFHEVLERQRLMQCDLEEE 507
E+EQR+ Q +A+ + +A E +E R+ ++E+E
Sbjct: 643 -EKEQRALENHLQQKHSAELQSLKDAHRESMEGFRI---EMEQE 682
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.129 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,480,558
Number of Sequences: 37866
Number of extensions: 1594032
Number of successful extensions: 9606
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 375
Number of HSP's that attempted gapping in prelim test: 8180
Number of HSP's gapped (non-prelim): 1324
length of query: 992
length of database: 18,247,518
effective HSP length: 112
effective length of query: 880
effective length of database: 14,006,526
effective search space: 12325742880
effective search space used: 12325742880
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.