Guide to the Human Genome
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Search of human proteins with 24308209

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24308209 X-linked neuroligin 4 [Homo sapiens]
         (816 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31317256 X-linked neuroligin 4 [Homo sapiens]                     1696   0.0  
gi|24308209 X-linked neuroligin 4 [Homo sapiens]                     1696   0.0  
gi|40538788 neuroligin 4, Y-linked [Homo sapiens]                    1656   0.0  
gi|51593088 neuroligin 3 [Homo sapiens]                              1231   0.0  
gi|7662470 neuroligin 1 [Homo sapiens]                               1221   0.0  
gi|30840978 neuroligin 2 [Homo sapiens]                              1033   0.0  
gi|4557351 butyrylcholinesterase precursor [Homo sapiens]             323   3e-88
gi|7710112 acetylcholinesterase isoform E4-E5 precursor [Homo sa...   320   3e-87
gi|4557239 acetylcholinesterase isoform E4-E6 precursor [Homo sa...   319   6e-87
gi|37622885 carboxylesterase 2 isoform 1 [Homo sapiens]               294   2e-79
gi|68508957 carboxylesterase 1 isoform c precursor [Homo sapiens]     293   6e-79
gi|68508965 carboxylesterase 1 isoform b precursor [Homo sapiens]     291   1e-78
gi|68508967 carboxylesterase 1 isoform a precursor [Homo sapiens]     291   2e-78
gi|219521907 carboxylesterase 7 isoform 1 [Homo sapiens]              288   2e-77
gi|148536848 carboxyl ester lipase precursor [Homo sapiens]           283   5e-76
gi|33563374 carboxylesterase 3 [Homo sapiens]                         283   5e-76
gi|37622887 carboxylesterase 2 isoform 2 [Homo sapiens]               280   3e-75
gi|21450749 carboxylesterase 7 isoform 2 [Homo sapiens]               239   7e-63
gi|115529439 carboxylesterase 8 (putative) [Homo sapiens]             231   3e-60
gi|55770862 thyroglobulin [Homo sapiens]                              193   6e-49
gi|169216018 PREDICTED: similar to hCG40360 [Homo sapiens]            155   1e-37
gi|169215613 PREDICTED: similar to hCG40360 [Homo sapiens]            155   1e-37
gi|239752162 PREDICTED: similar to hCG40360 [Homo sapiens]             92   2e-18
gi|11055976 carbohydrate (N-acetylglucosamine 6-O) sulfotransfer...    34   0.48 
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]           33   0.82 
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]           33   0.82 
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]           33   0.82 
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]           33   0.82 
gi|10937869 survival of motor neuron 2, centromeric isoform d [H...    32   1.8  
gi|4507091 survival of motor neuron 1, telomeric isoform d [Homo...    32   1.8  

>gi|31317256 X-linked neuroligin 4 [Homo sapiens]
          Length = 816

 Score = 1696 bits (4392), Expect = 0.0
 Identities = 816/816 (100%), Positives = 816/816 (100%)

Query: 1   MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT 60
           MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT
Sbjct: 1   MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT 60

Query: 61  PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL 120
           PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL
Sbjct: 61  PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL 120

Query: 121 HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG 180
           HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG
Sbjct: 121 HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG 180

Query: 181 TGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGA 240
           TGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGA
Sbjct: 181 TGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGA 240

Query: 241 FGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRIL 300
           FGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRIL
Sbjct: 241 FGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRIL 300

Query: 301 ADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQG 360
           ADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQG
Sbjct: 301 ADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQG 360

Query: 361 EFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETI 420
           EFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETI
Sbjct: 361 EFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETI 420

Query: 421 KFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEM 480
           KFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEM
Sbjct: 421 KFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEM 480

Query: 481 KPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV 540
           KPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV
Sbjct: 481 KPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV 540

Query: 541 PQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNL 600
           PQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNL
Sbjct: 541 PQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNL 600

Query: 601 NEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPED 660
           NEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPED
Sbjct: 601 NEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPED 660

Query: 661 TTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTND 720
           TTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTND
Sbjct: 661 TTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTND 720

Query: 721 IAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTIT 780
           IAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTIT
Sbjct: 721 IAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTIT 780

Query: 781 MIPNTLTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV 816
           MIPNTLTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV
Sbjct: 781 MIPNTLTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV 816


>gi|24308209 X-linked neuroligin 4 [Homo sapiens]
          Length = 816

 Score = 1696 bits (4392), Expect = 0.0
 Identities = 816/816 (100%), Positives = 816/816 (100%)

Query: 1   MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT 60
           MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT
Sbjct: 1   MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT 60

Query: 61  PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL 120
           PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL
Sbjct: 61  PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL 120

Query: 121 HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG 180
           HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG
Sbjct: 121 HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG 180

Query: 181 TGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGA 240
           TGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGA
Sbjct: 181 TGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGA 240

Query: 241 FGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRIL 300
           FGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRIL
Sbjct: 241 FGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRIL 300

Query: 301 ADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQG 360
           ADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQG
Sbjct: 301 ADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQG 360

Query: 361 EFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETI 420
           EFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETI
Sbjct: 361 EFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETI 420

Query: 421 KFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEM 480
           KFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEM
Sbjct: 421 KFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEM 480

Query: 481 KPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV 540
           KPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV
Sbjct: 481 KPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV 540

Query: 541 PQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNL 600
           PQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNL
Sbjct: 541 PQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNL 600

Query: 601 NEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPED 660
           NEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPED
Sbjct: 601 NEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPED 660

Query: 661 TTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTND 720
           TTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTND
Sbjct: 661 TTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTND 720

Query: 721 IAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTIT 780
           IAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTIT
Sbjct: 721 IAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTIT 780

Query: 781 MIPNTLTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV 816
           MIPNTLTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV
Sbjct: 781 MIPNTLTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV 816


>gi|40538788 neuroligin 4, Y-linked [Homo sapiens]
          Length = 816

 Score = 1656 bits (4289), Expect = 0.0
 Identities = 796/816 (97%), Positives = 803/816 (98%)

Query: 1   MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT 60
           M RPQGLLWLPLLFT VCVMLNSNVLLW+TALAIKFTLIDSQAQYPVVNTNYGKI+GLRT
Sbjct: 1   MLRPQGLLWLPLLFTSVCVMLNSNVLLWITALAIKFTLIDSQAQYPVVNTNYGKIQGLRT 60

Query: 61  PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL 120
           PLP+EILGPVEQYLGVPYASPPTGERRFQPPE PSSWTGIRN TQF+AVCPQHLDER LL
Sbjct: 61  PLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVCPQHLDERFLL 120

Query: 121 HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG 180
           HDMLPIWFT +LDTLMTYVQDQNEDCLYLNIYVP EDDIH+QNSKKPVMVYIHGGSYMEG
Sbjct: 121 HDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDDIHEQNSKKPVMVYIHGGSYMEG 180

Query: 181 TGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGA 240
           TGNMIDGSILASYGNVIVITIN RLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGA
Sbjct: 181 TGNMIDGSILASYGNVIVITINCRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGA 240

Query: 241 FGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRIL 300
           FGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRIL
Sbjct: 241 FGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRIL 300

Query: 301 ADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQG 360
           ADKVGCNMLDTTDMVECL+NKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQG
Sbjct: 301 ADKVGCNMLDTTDMVECLKNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQG 360

Query: 361 EFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETI 420
           EFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETI
Sbjct: 361 EFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETI 420

Query: 421 KFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEM 480
           KFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEM
Sbjct: 421 KFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEM 480

Query: 481 KPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV 540
           KPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV
Sbjct: 481 KPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV 540

Query: 541 PQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNL 600
           PQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNL
Sbjct: 541 PQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNL 600

Query: 601 NEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPED 660
           NEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPED
Sbjct: 601 NEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPED 660

Query: 661 TTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTND 720
           TTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHR PSPQRNTTND
Sbjct: 661 TTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRHPSPQRNTTND 720

Query: 721 IAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTIT 780
           I HIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIP MTPNTIT
Sbjct: 721 ITHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPFMTPNTIT 780

Query: 781 MIPNTLTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV 816
           MIPNTL GMQPLHTF TFSGGQNSTNLPHGHSTTRV
Sbjct: 781 MIPNTLMGMQPLHTFKTFSGGQNSTNLPHGHSTTRV 816


>gi|51593088 neuroligin 3 [Homo sapiens]
          Length = 828

 Score = 1231 bits (3186), Expect = 0.0
 Identities = 594/811 (73%), Positives = 680/811 (83%), Gaps = 29/811 (3%)

Query: 27  LWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGER 86
           LW  +LA++ +   +QA  P VNT++GK+RG R PLP+EILGPV+QYLGVPYA+PP GE+
Sbjct: 26  LWFLSLALRAS---TQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEK 82

Query: 87  RFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDC 146
           RF PPEPP SW+GIRN T F  VCPQ++   ++   MLP+WFTANLD + TY+Q+ NEDC
Sbjct: 83  RFLPPEPPPSWSGIRNATHFPPVCPQNI-HTAVPEVMLPVWFTANLDIVATYIQEPNEDC 141

Query: 147 LYLNIYVPTED--------------------DIHDQNSKKPVMVYIHGGSYMEGTGNMID 186
           LYLN+YVPTED                    DI D  +K PVMVYIHGGSYMEGTGNMID
Sbjct: 142 LYLNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAK-PVMVYIHGGSYMEGTGNMID 200

Query: 187 GSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPK 246
           GSILASYGNVIVIT+NYR+G+LGFLSTGDQAAKGNYGLLDQIQALRW+ EN+  FGGDP+
Sbjct: 201 GSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPR 260

Query: 247 RVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGC 306
           R+T+FGSG GASCVSLLTLSH+SEGLFQ+AIIQSG+ALSSWAVNYQP KYT +LADKVGC
Sbjct: 261 RITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGC 320

Query: 307 NMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYD 366
           N+LDT DMV+CLR K+ KEL++Q I PA YH+AFGPVIDGDVIPDDP+ILMEQGEFLNYD
Sbjct: 321 NVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYD 380

Query: 367 IMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTD 426
           IMLGVNQGEGLKFV+G+VD EDGV+  DFD+SVSNFVDNLYGYPEGKDTLRETIKFMYTD
Sbjct: 381 IMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTD 440

Query: 427 WADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWAD 486
           WAD++NPETRRKTLVALFTDHQWV P+V TADLHA+YGSPTYFYAFYHHCQS MKP+W+D
Sbjct: 441 WADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSD 500

Query: 487 SAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF 546
           +AHGDEVPYVFG+PM+GPT+LF CNFSKNDVMLSAVVMTYWTNFAKTGDPN+PVPQDTKF
Sbjct: 501 AAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKF 560

Query: 547 IHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQY 606
           IHTK NRFEEVAWSKYNP+DQLYLHIGLKPRVRDHYRATKVAFW  LVPHL+NL+++F Y
Sbjct: 561 IHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHY 620

Query: 607 VSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTTVLIE 666
            STTTKVPPPD T   + TRR   K W +TKRPAI+PA + ++++       +   +L+E
Sbjct: 621 TSTTTKVPPPDTTHSSHITRRPNGKTW-STKRPAISPAYSNENAQGSWNGDQDAGPLLVE 679

Query: 667 TKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNT-TNDIAHIQ 725
             RDYSTELSVTIAVGASLLFLN+LAFAALYY+KDKRR E  R+PSPQR     ++    
Sbjct: 680 NPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGAGAPELGAAP 739

Query: 726 NEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTITMIPNT 785
            EE+ +LQ+      HECE+   HDTLRLT  PDYTLTLRRSPDDIPLMTPNTITMIPN+
Sbjct: 740 EEELAALQLGPTH--HECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNS 797

Query: 786 LTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV 816
           L G+Q LH +NTF+ G NST LPH HSTTRV
Sbjct: 798 LVGLQTLHPYNTFAAGFNSTGLPHSHSTTRV 828


>gi|7662470 neuroligin 1 [Homo sapiens]
          Length = 823

 Score = 1221 bits (3159), Expect = 0.0
 Identities = 590/789 (74%), Positives = 662/789 (83%), Gaps = 36/789 (4%)

Query: 46  PVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQ 105
           P+V TN+GKIRG++  L NEILGPV Q+LGVPYA+PPTGERRFQPPEPPS W+ IRN TQ
Sbjct: 53  PLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQ 112

Query: 106 FAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSK 165
           FA VCPQ++ +  L   MLP+WFT NLD + +YVQDQ+EDCLYLNIYVPTEDDI D    
Sbjct: 113 FAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDDIRDSGGP 172

Query: 166 KPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLL 225
           KPVMVYIHGGSYMEGTGN+ DGS+LASYGNVIVIT+NYRLG+LGFLSTGDQAAKGNYGLL
Sbjct: 173 KPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLL 232

Query: 226 DQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEG---------LFQKA 276
           D IQALRW  EN+G FGGDP R+T+FGSGAG SCV+LLTLSHYSEG         LFQ+A
Sbjct: 233 DLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRA 292

Query: 277 IIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATY 336
           I QSGTALSSWAV++QPAKY R+LA KVGCN+ DT ++VECL+ K YKEL+ Q I PA Y
Sbjct: 293 IAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARY 352

Query: 337 HIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFD 396
           HIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV+ IVD++DG++ +DFD
Sbjct: 353 HIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFD 412

Query: 397 FSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVAT 456
           F+VSNFVDNLYGYPEGKD LRETIKFMYTDWAD+ NPETRRKTL+ALFTDHQWVAPAVAT
Sbjct: 413 FAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVAT 472

Query: 457 ADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKND 516
           ADLH+ +GSPTYFYAFYHHCQ++  P+WAD+AHGDEVPYV GIPMIGPTELF CNFSKND
Sbjct: 473 ADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKND 532

Query: 517 VMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP 576
           VMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAW++Y+ KDQLYLHIGLKP
Sbjct: 533 VMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKP 592

Query: 577 RVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKI---W 633
           RV++HYRA KV  WLELVPHLHNLN+I QY STTTKVP  D+T  P  TR++   +   +
Sbjct: 593 RVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITFRP--TRKNSVPVTSAF 650

Query: 634 PTTKRPAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAF 693
           PT K+      ++PK    P              +RDYSTELSVTIAVGASLLFLNILAF
Sbjct: 651 PTAKQ------DDPKQQPSPFSV----------DQRDYSTELSVTIAVGASLLFLNILAF 694

Query: 694 AALYYKKDKRRHETHRRPSPQRNTTNDIAHIQNEEIMSLQMKQLEHDHECESLQAHD-TL 752
           AALYYKKDKRRH+ HRR SPQR TTND+ H Q EEIMSLQMK  + DHECES+  H+  L
Sbjct: 695 AALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDHECESIHPHEVVL 754

Query: 753 RLTCPPDYTLTLRRSPDDIPLMTPNTITMIPNTLTGMQPLHTFNTFSGGQNST-----NL 807
           R  CPPDYTL +RRSPDD+PLMTPNTITMIPNT+ G+QPLHTFNTF+GGQN+T       
Sbjct: 755 RTACPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPH 814

Query: 808 PHGHSTTRV 816
           PH HSTTRV
Sbjct: 815 PHSHSTTRV 823


>gi|30840978 neuroligin 2 [Homo sapiens]
          Length = 835

 Score = 1033 bits (2671), Expect = 0.0
 Identities = 519/816 (63%), Positives = 616/816 (75%), Gaps = 59/816 (7%)

Query: 42  QAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIR 101
           + ++PVVNT YG++RG+R  L NEILGPV Q+LGVPYA+PP G RRFQPPE P+SW G+R
Sbjct: 38  EERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVR 97

Query: 102 NTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTED---- 157
           N T     CPQ+L   +L   MLP+WFT NL+   TYVQ+Q+EDCLYLN+YVPTED    
Sbjct: 98  NATTLPPACPQNL-HGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLT 156

Query: 158 -------------DIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYR 204
                        DI D   KKPVM+++HGGSYMEGTGNM DGS+LA+YGNVIV T+NYR
Sbjct: 157 KKRDEATLNPPDTDIRDPG-KKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYR 215

Query: 205 LGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLT 264
           LG+LGFLSTGDQAAKGNYGLLDQIQALRW+ EN+  FGGDP+R+TIFGSGAGASCV+LL 
Sbjct: 216 LGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLI 275

Query: 265 LSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYK 324
           LSH+SEGLFQKAI QSGTA+SSW+VNYQP KYTR+LA KVGC+  D+ + VECLR K  +
Sbjct: 276 LSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSR 335

Query: 325 ELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIV 384
           EL+ Q + PA YHIAFGPV+DGDV+PDDP+ILM+QGEFLNYD+++GVNQGEGLKFV+   
Sbjct: 336 ELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSA 395

Query: 385 DNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALF 444
           ++EDGV+ + FDF+VSNFVDNLYGYPEGKD LRETIKFMYTDWAD++N E RRKTL+ALF
Sbjct: 396 ESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALF 455

Query: 445 TDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGP 504
           TDHQWVAPAVATA LHA Y SP YFY FYHHCQ+E +P WAD+AHGDE+PYVFG+PM+G 
Sbjct: 456 TDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGA 515

Query: 505 TELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNP 564
           T+LF CNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEV WSK+N 
Sbjct: 516 TDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNS 575

Query: 565 KDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLN-EIFQYVSTTTKVPPPDMTSFPY 623
           K++ YLHIGLKPRVRD+YRA KVAFWLELVPHLHNL+ E+F   +TTT++P       PY
Sbjct: 576 KEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELF---TTTTRLP-------PY 625

Query: 624 GTR---RSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIA 680
            TR   R PA   P T+RP       P+   +P   GP          RDYSTELSVT+A
Sbjct: 626 ATRWPPRPPAGA-PGTRRPPPPATLPPEPEPEP---GPRAYDRFPGDSRDYSTELSVTVA 681

Query: 681 VGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTNDIAHIQNEEIMSLQMKQLEHD 740
           VGASLLFLNILAFAALYYK+D+R+    RR SP   + + +       ++    ++L  +
Sbjct: 682 VGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVP--GGGPLLPAAGRELPPE 739

Query: 741 HECESLQAH----------DTLRLTCPPDYTLTLRRSPDDIPLMTPNTITMIPNTLTGMQ 790
            E  SLQ            + LR  CPPDYTL LRR+PDD+PL+ P  +T++P+ L    
Sbjct: 740 EELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPP 799

Query: 791 P-----LHTFNTF-----SGGQNSTNLPHGHSTTRV 816
           P     LH F  F     +   ++  LPH HSTTRV
Sbjct: 800 PPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV 835


>gi|4557351 butyrylcholinesterase precursor [Homo sapiens]
          Length = 602

 Score =  323 bits (829), Expect = 3e-88
 Identities = 192/564 (34%), Positives = 298/564 (52%), Gaps = 56/564 (9%)

Query: 47  VVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQF 106
           ++ T  GK+RG+   +     G V  +LG+PYA PP G  RF+ P+  + W+ I N T++
Sbjct: 33  IIATKNGKVRGMNLTVFG---GTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKY 89

Query: 107 AAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKK 166
           A  C Q++D+         +W   N +T      D +EDCLYLN+++P       +    
Sbjct: 90  ANSCCQNIDQSFPGFHGSEMW---NPNT------DLSEDCLYLNVWIPAP-----KPKNA 135

Query: 167 PVMVYIHGGSYMEGTGNM--IDGSILASYGNVIVITINYRLGILGFLST-GDQAAKGNYG 223
            V+++I+GG +  GT ++   DG  LA    VIV+++NYR+G LGFL+  G+  A GN G
Sbjct: 136 TVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMG 195

Query: 224 LLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTA 283
           L DQ  AL+W+++N+ AFGG+PK VT+FG  AGA+ VSL  LS  S  LF +AI+QSG+ 
Sbjct: 196 LFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSF 255

Query: 284 LSSWAVN--YQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATY----H 337
            + WAV   Y+    T  LA   GC+  + T++++CLRNK+ +E++        Y     
Sbjct: 256 NAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLS 315

Query: 338 IAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV-----DGIVDNEDGVTP 392
           + FGP +DGD + D P IL+E G+F    I++GVN+ EG  F+         DN   +T 
Sbjct: 316 VNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITR 375

Query: 393 NDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAP 452
            +F   +  F      +P   +  +E+I F YTDW D + PE  R+ L  +  D+ ++ P
Sbjct: 376 KEFQEGLKIF------FPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICP 429

Query: 453 AVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNF 512
           A+      +++G+  +FY F H       P W    HG E+ +VFG+P+         N+
Sbjct: 430 ALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRD-----NY 484

Query: 513 SKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHI 572
           +K + +LS  ++  W NFAK G+PN+     T             +W  +   +Q YL +
Sbjct: 485 TKAEEILSRSIVKRWANFAKYGNPNETQNNST-------------SWPVFKSTEQKYLTL 531

Query: 573 GLK-PRVRDHYRATKVAFWLELVP 595
             +  R+    RA +  FW    P
Sbjct: 532 NTESTRIMTKLRAQQCRFWTSFFP 555


>gi|7710112 acetylcholinesterase isoform E4-E5 precursor [Homo
           sapiens]
          Length = 617

 Score =  320 bits (821), Expect = 3e-87
 Identities = 213/643 (33%), Positives = 312/643 (48%), Gaps = 74/643 (11%)

Query: 1   MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT 60
           M  PQ LL  P L +P+ ++L     LWL    +       +    +V    G++RG+R 
Sbjct: 1   MRPPQCLLHTPSLASPLLLLL-----LWLLGGGVGAE--GREDAELLVTVRGGRLRGIRL 53

Query: 61  PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL 120
             P    GPV  +LG+P+A PP G RRF PPEP   W+G+ + T F +VC Q++D     
Sbjct: 54  KTPG---GPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPG 110

Query: 121 HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG 180
            +   +W            ++ +EDCLYLN++ P         S  PV+V+I+GG +  G
Sbjct: 111 FEGTEMWNPN---------RELSEDCLYLNVWTPYPRP----TSPTPVLVWIYGGGFYSG 157

Query: 181 TGNM--IDGSILASYGNVIVITINYRLGILGFLST-GDQAAKGNYGLLDQIQALRWIEEN 237
             ++   DG  L      +++++NYR+G  GFL+  G + A GN GLLDQ  AL+W++EN
Sbjct: 158 ASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQEN 217

Query: 238 VGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAV--NYQPAK 295
           V AFGGDP  VT+FG  AGA+ V +  LS  S GLF +A++QSG     WA     +  +
Sbjct: 218 VAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARR 277

Query: 296 YTRILADKVGCNMLDT----TDMVECLRNKNYKELIQQT--ITP--ATYHIAFGPVIDGD 347
               LA  VGC    T    T++V CLR +  + L+     + P  + +  +F PV+DGD
Sbjct: 278 RATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGD 337

Query: 348 VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV-----DGIVDNEDGVTPNDFDFSVSNF 402
            + D P+ L+  G+F    +++GV + EG  F+         DNE  ++  +F   V   
Sbjct: 338 FLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVR-- 395

Query: 403 VDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQ 462
                G P+  D   E +   YTDW   E+P   R+ L  +  DH  V P    A   A 
Sbjct: 396 ----VGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAA 451

Query: 463 YGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAV 522
            G+  Y Y F H   +   P W    HG E+ ++FGIP+       S N++  + + +  
Sbjct: 452 QGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDP-----SRNYTAEEKIFAQR 506

Query: 523 VMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP-RVRDH 581
           +M YW NFA+TGDPN+  P+D K             W  Y    Q Y+ + L+P  VR  
Sbjct: 507 LMRYWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRG 554

Query: 582 YRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYG 624
            RA   AFW   +P L         +S T    P     F +G
Sbjct: 555 LRAQACAFWNRFLPKL---------LSATASEAPSTCPGFTHG 588


>gi|4557239 acetylcholinesterase isoform E4-E6 precursor [Homo
           sapiens]
          Length = 614

 Score =  319 bits (818), Expect = 6e-87
 Identities = 208/616 (33%), Positives = 305/616 (49%), Gaps = 65/616 (10%)

Query: 1   MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT 60
           M  PQ LL  P L +P+ ++L     LWL    +       +    +V    G++RG+R 
Sbjct: 1   MRPPQCLLHTPSLASPLLLLL-----LWLLGGGVGAE--GREDAELLVTVRGGRLRGIRL 53

Query: 61  PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL 120
             P    GPV  +LG+P+A PP G RRF PPEP   W+G+ + T F +VC Q++D     
Sbjct: 54  KTPG---GPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPG 110

Query: 121 HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG 180
            +   +W            ++ +EDCLYLN++ P         S  PV+V+I+GG +  G
Sbjct: 111 FEGTEMWNPN---------RELSEDCLYLNVWTPYPRP----TSPTPVLVWIYGGGFYSG 157

Query: 181 TGNM--IDGSILASYGNVIVITINYRLGILGFLST-GDQAAKGNYGLLDQIQALRWIEEN 237
             ++   DG  L      +++++NYR+G  GFL+  G + A GN GLLDQ  AL+W++EN
Sbjct: 158 ASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQEN 217

Query: 238 VGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAV--NYQPAK 295
           V AFGGDP  VT+FG  AGA+ V +  LS  S GLF +A++QSG     WA     +  +
Sbjct: 218 VAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARR 277

Query: 296 YTRILADKVGCNMLDT----TDMVECLRNKNYKELIQQT--ITP--ATYHIAFGPVIDGD 347
               LA  VGC    T    T++V CLR +  + L+     + P  + +  +F PV+DGD
Sbjct: 278 RATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGD 337

Query: 348 VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV-----DGIVDNEDGVTPNDFDFSVSNF 402
            + D P+ L+  G+F    +++GV + EG  F+         DNE  ++  +F   V   
Sbjct: 338 FLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVR-- 395

Query: 403 VDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQ 462
                G P+  D   E +   YTDW   E+P   R+ L  +  DH  V P    A   A 
Sbjct: 396 ----VGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAA 451

Query: 463 YGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAV 522
            G+  Y Y F H   +   P W    HG E+ ++FGIP+       S N++  + + +  
Sbjct: 452 QGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDP-----SRNYTAEEKIFAQR 506

Query: 523 VMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP-RVRDH 581
           +M YW NFA+TGDPN+  P+D K             W  Y    Q Y+ + L+P  VR  
Sbjct: 507 LMRYWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRG 554

Query: 582 YRATKVAFWLELVPHL 597
            RA   AFW   +P L
Sbjct: 555 LRAQACAFWNRFLPKL 570


>gi|37622885 carboxylesterase 2 isoform 1 [Homo sapiens]
          Length = 623

 Score =  294 bits (753), Expect = 2e-79
 Identities = 192/578 (33%), Positives = 294/578 (50%), Gaps = 61/578 (10%)

Query: 31  ALAIKFTLIDSQAQ---YPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERR 87
           A  +   L+  Q Q    P+  T+ G++ G    +     G V+ +LG+P+A PP G  R
Sbjct: 78  ACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAG-VQTFLGIPFAKPPLGPLR 136

Query: 88  FQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQ-NEDC 146
           F PPEPP SW+G+R+ T   A+C         L D+  +         MT+  D  +EDC
Sbjct: 137 FAPPEPPESWSGVRDGTTHPAMC---------LQDLTAVESEFLSQFNMTFPSDSMSEDC 187

Query: 147 LYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLG 206
           LYL+IY P       + S  PVMV+IHGG+ + G  ++ DGS+LA+  NV+V+ I YRLG
Sbjct: 188 LYLSIYTPAHSH---EGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLG 244

Query: 207 ILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLS 266
           +LGF STGD+ A GN+G LDQ+ ALRW+++N+  FGG+P RVTIFG  AG + VS L +S
Sbjct: 245 VLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVS 304

Query: 267 HYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKEL 326
             S+GLF  AI++SG AL    +       + ++A+   C+ +D+  +V CLR K+ +E+
Sbjct: 305 PISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEI 364

Query: 327 IQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEG---LKFVDGI 383
           +        + +  G V+DG  +P  PQ L+   +F     ++GVN  E    +  V  I
Sbjct: 365 L---AINKPFKMIPG-VVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRI 420

Query: 384 VDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVAL 443
            D +  +       ++   +  L   P   D LRE          D  +P+T +     +
Sbjct: 421 YDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEY------IGDNGDPQTLQAQFQEM 474

Query: 444 FTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQ--SEMKPSWADSAHGDEVPYVFGIPM 501
             D  +V PA+  A       +P YFY F H       ++P    + HGDE+P+VF    
Sbjct: 475 MADSMFVIPALQVAHFQCS-RAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVF---- 529

Query: 502 IGPTELFSCN---FSKNDVMLSAVVMTYWTNFAKTGDPN-QPVPQDTKFIHTKPNRFEEV 557
                 F  N   F++ +  LS  +M YW NFA+ G+PN + +P                
Sbjct: 530 ---RSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPH--------------- 571

Query: 558 AWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVP 595
            W  ++ ++Q YL + L+P V    +A ++ FW + +P
Sbjct: 572 -WPLFDQEEQ-YLQLNLQPAVGRALKAHRLQFWKKALP 607


>gi|68508957 carboxylesterase 1 isoform c precursor [Homo sapiens]
          Length = 566

 Score =  293 bits (749), Expect = 6e-79
 Identities = 199/588 (33%), Positives = 294/588 (50%), Gaps = 60/588 (10%)

Query: 27  LWLTALAIKFTLIDSQA-----QYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASP 81
           +WL A  +  TL  S A       PVV+T +GK+ G    L      PV  +LG+P+A P
Sbjct: 1   MWLRAFILA-TLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEG-FAQPVAIFLGIPFAKP 58

Query: 82  PTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQD 141
           P G  RF PP+P   W+ ++N T +  +C Q      LL ++    FT   + +   +  
Sbjct: 59  PLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSEL----FTNRKENIPLKL-- 112

Query: 142 QNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITI 201
            +EDCLYLNIY P   D+  +N + PVMV+IHGG  M G  +  DG  LA++ NV+V+TI
Sbjct: 113 -SEDCLYLNIYTPA--DLTKKN-RLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTI 168

Query: 202 NYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVS 261
            YRLGI GF STGD+ ++GN+G LDQ+ ALRW+++N+ +FGG+P  VTIFG  AG   VS
Sbjct: 169 QYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVS 228

Query: 262 LLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAK-YTRILADKVGCNMLDTTDMVECLRN 320
           +L LS  ++ LF +AI +SG AL+S  V     K     +A   GC    +  MV CLR 
Sbjct: 229 VLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQ 288

Query: 321 KNYKELIQQTI-----------TPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIML 369
           K  +EL++ T+            P       G VIDG ++   P+ L  +  F     M+
Sbjct: 289 KTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMV 348

Query: 370 GVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRE-TIKFMYTDWA 428
           G+N+ E    +  ++         D   ++S    +       K+ + E T K++     
Sbjct: 349 GINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYL----G 404

Query: 429 DKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHH--CQSEMKPSWAD 486
             ++   ++   + L  D  +  P+V  A  H   G+PTY Y F +     S+MKP    
Sbjct: 405 GTDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVI 464

Query: 487 SAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPN-QPVPQDTK 545
             HGDE+  VFG P +          S+ ++ LS +VM +W NFA+ G+PN + +P    
Sbjct: 465 GDHGDELFSVFGAPFLKE------GASEEEIRLSKMVMKFWANFARNGNPNGEGLPH--- 515

Query: 546 FIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLEL 593
                        W +YN K+  YL IG   +     +  +VAFW  L
Sbjct: 516 -------------WPEYNQKEG-YLQIGANTQAAQKLKDKEVAFWTNL 549


>gi|68508965 carboxylesterase 1 isoform b precursor [Homo sapiens]
          Length = 567

 Score =  291 bits (746), Expect = 1e-78
 Identities = 200/597 (33%), Positives = 294/597 (49%), Gaps = 77/597 (12%)

Query: 27  LWLTALAIKFTLIDSQA-----QYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASP 81
           +WL A  +  TL  S A       PVV+T +GK+ G    L      PV  +LG+P+A P
Sbjct: 1   MWLRAFILA-TLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEG-FAQPVAIFLGIPFAKP 58

Query: 82  PTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQD 141
           P G  RF PP+P   W+ ++N T +  +C Q      LL ++    FT   + +   +  
Sbjct: 59  PLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSEL----FTNRKENIPLKL-- 112

Query: 142 QNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITI 201
            +EDCLYLNIY P   D+  +N + PVMV+IHGG  M G  +  DG  LA++ NV+V+TI
Sbjct: 113 -SEDCLYLNIYTPA--DLTKKN-RLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTI 168

Query: 202 NYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVS 261
            YRLGI GF STGD+ ++GN+G LDQ+ ALRW+++N+ +FGG+P  VTIFG  AG   VS
Sbjct: 169 QYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVS 228

Query: 262 LLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAK-YTRILADKVGCNMLDTTDMVECLRN 320
           +L LS  ++ LF +AI +SG AL+S  V     K     +A   GC    +  MV CLR 
Sbjct: 229 VLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQ 288

Query: 321 KNYKELIQQTI-----------TPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIML 369
           K  +EL++ T+            P       G VIDG ++   P+ L  +  F     M+
Sbjct: 289 KTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMV 348

Query: 370 GVNQGE----------GLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRET 419
           G+N+ E               +G +D +  ++     + +      L   PE       T
Sbjct: 349 GINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKEL--IPEA------T 400

Query: 420 IKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHH--CQ 477
            K++       ++   ++   + L  D  +  P+V  A  H   G+PTY Y F +     
Sbjct: 401 EKYL----GGTDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFS 456

Query: 478 SEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPN 537
           S+MKP      HGDE+  VFG P +          S+ ++ LS +VM +W NFA+ G+PN
Sbjct: 457 SDMKPKTVIGDHGDELFSVFGAPFLKE------GASEEEIRLSKMVMKFWANFARNGNPN 510

Query: 538 -QPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLEL 593
            + +P                 W +YN K+  YL IG   +     +  +VAFW  L
Sbjct: 511 GEGLPH----------------WPEYNQKEG-YLQIGANTQAAQKLKDKEVAFWTNL 550


>gi|68508967 carboxylesterase 1 isoform a precursor [Homo sapiens]
          Length = 568

 Score =  291 bits (745), Expect = 2e-78
 Identities = 193/573 (33%), Positives = 285/573 (49%), Gaps = 71/573 (12%)

Query: 46  PVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQ 105
           PVV+T +GK+ G    L      PV  +LG+P+A PP G  RF PP+P   W+ ++N T 
Sbjct: 25  PVVDTVHGKVLGKFVSLEG-FAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATS 83

Query: 106 FAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSK 165
           +  +C Q      LL ++    FT   + +   +   +EDCLYLNIY P   D+  +N +
Sbjct: 84  YPPMCTQDPKAGQLLSEL----FTNRKENIPLKL---SEDCLYLNIYTPA--DLTKKN-R 133

Query: 166 KPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLL 225
            PVMV+IHGG  M G  +  DG  LA++ NV+V+TI YRLGI GF STGD+ ++GN+G L
Sbjct: 134 LPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHL 193

Query: 226 DQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALS 285
           DQ+ ALRW+++N+ +FGG+P  VTIFG  AG   VS+L LS  ++ LF +AI +SG AL+
Sbjct: 194 DQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALT 253

Query: 286 SWAVNYQPAK-YTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTI-----------TP 333
           S  V     K     +A   GC    +  MV CLR K  +EL++ T+            P
Sbjct: 254 SVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDP 313

Query: 334 ATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGE----------GLKFVDGI 383
                  G VIDG ++   P+ L  +  F     M+G+N+ E               +G 
Sbjct: 314 RESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQ 373

Query: 384 VDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVAL 443
           +D +  ++     + +      L   PE       T K++       ++   ++   + L
Sbjct: 374 LDQKTAMSLLWKSYPLVCIAKEL--IPEA------TEKYL----GGTDDTVKKKDLFLDL 421

Query: 444 FTDHQWVAPAVATADLHAQYGSPTYFYAFYHH--CQSEMKPSWADSAHGDEVPYVFGIPM 501
             D  +  P+V  A  H   G+PTY Y F +     S+MKP      HGDE+  VFG P 
Sbjct: 422 IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF 481

Query: 502 IGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPN-QPVPQDTKFIHTKPNRFEEVAWS 560
           +          S+ ++ LS +VM +W NFA+ G+PN + +P                 W 
Sbjct: 482 LKE------GASEEEIRLSKMVMKFWANFARNGNPNGEGLPH----------------WP 519

Query: 561 KYNPKDQLYLHIGLKPRVRDHYRATKVAFWLEL 593
           +YN K+  YL IG   +     +  +VAFW  L
Sbjct: 520 EYNQKEG-YLQIGANTQAAQKLKDKEVAFWTNL 551


>gi|219521907 carboxylesterase 7 isoform 1 [Homo sapiens]
          Length = 575

 Score =  288 bits (736), Expect = 2e-77
 Identities = 190/573 (33%), Positives = 294/573 (51%), Gaps = 48/573 (8%)

Query: 27  LWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGER 86
           +W+ A   K       A+ P  NT  G I+G +  +    + PV  +LGVP+A+PP G  
Sbjct: 16  IWVLAAPTK----GPSAEGPQRNTRLGWIQGKQVTVLGSPV-PVNVFLGVPFAAPPLGSL 70

Query: 87  RFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDC 146
           RF  P+P S W  +R  T +  +C Q+ +   L   ML + +              +EDC
Sbjct: 71  RFTNPQPASPWDNLREATSYPNLCLQNSEWLLLDQHMLKVHYPKF---------GVSEDC 121

Query: 147 LYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLG 206
           LYLNIY P   D     SK PV+V+  GG++  G+ ++ DGS LA+Y +V+V+ + YRLG
Sbjct: 122 LYLNIYAPAHADT---GSKLPVLVWFPGGAFKTGSASIFDGSALAAYEDVLVVVVQYRLG 178

Query: 207 ILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLS 266
           I GF +T DQ A GN+   DQ+ AL W+++N+  FGGDP  VTIFG  AGA  VS L LS
Sbjct: 179 IFGFFTTWDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILS 238

Query: 267 HYSEGLFQKAIIQSGTALSSW--AVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYK 324
             ++GLF KAI++SG A+  +  A +Y+ ++  +++A   G N  D+  ++ CLR K  K
Sbjct: 239 PMAKGLFHKAIMESGVAIIPYLEAHDYEKSEDLQVVAHFCGNNASDSEALLRCLRTKPSK 298

Query: 325 ELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIV 384
           EL+  T++  T   +F  V+DG   P++P  L+ Q  F     ++GVN  E   F+  + 
Sbjct: 299 ELL--TLSQKTK--SFTRVVDGAFFPNEPLDLLSQKAFKAIPSIIGVNNHE-CGFLLPMK 353

Query: 385 DNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALF 444
           +  + ++ ++   ++ + + N+   P     L     F      DK +    R +L+ L 
Sbjct: 354 EAPEILSGSNKSLAL-HLIQNILHIPPQYLHLVANEYF-----HDKHSLTEIRDSLLDLL 407

Query: 445 TDHQWVAPAVATADLHAQYGSPTYFYAFYH--HCQSEMKPSWADSAHGDEVPYVFGIPMI 502
            D  +V PA+ TA  H   G+P YFY F H   C  + KP++  + H DEV +VFG   +
Sbjct: 408 GDVFFVVPALITARYHRDAGAPVYFYEFRHRPQCFEDTKPAFVKADHADEVRFVFGGAFL 467

Query: 503 GPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKY 562
               +     ++ + +LS  +M YW  FA+TG+PN                 +   W  Y
Sbjct: 468 KGDIVMFEGATEEEKLLSRKMMKYWATFARTGNPNGN---------------DLSLWPAY 512

Query: 563 NPKDQLYLHIGLKPRVRDHYRATKVAFWLELVP 595
           N  +Q YL + L   +    +  +V FW   +P
Sbjct: 513 NLTEQ-YLQLDLNMSLGQRLKEPRVDFWTSTIP 544


>gi|148536848 carboxyl ester lipase precursor [Homo sapiens]
          Length = 756

 Score =  283 bits (724), Expect = 5e-76
 Identities = 187/522 (35%), Positives = 264/522 (50%), Gaps = 63/522 (12%)

Query: 39  IDSQAQYPVVNTNYGKIRGLRTPLPNEILGP-VEQYLGVPYASPPTGERRFQPPEPPSSW 97
           + S A+   V T  G + G+   L   +LG  V+ + G+P+A+P    +  + P+P   W
Sbjct: 20  VASAAKLGAVYTEGGFVEGVNKKLG--LLGDSVDIFKGIPFAAPT---KALENPQPHPGW 74

Query: 98  TGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTED 157
            G      F   C Q                 A +    TY    +EDCLYLNI+VP   
Sbjct: 75  QGTLKAKNFKKRCLQ-----------------ATITQDSTY---GDEDCLYLNIWVPQG- 113

Query: 158 DIHDQNSKK-PVMVYIHGGSYMEGTGN--------MIDGSILASYGNVIVITINYRLGIL 208
               Q S+  PVM++I+GG+++ G+G+        + DG  +A+ GNVIV+T NYR+G L
Sbjct: 114 --RKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPL 171

Query: 209 GFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHY 268
           GFLSTGD    GNYGL DQ  A+ W++ N+ AFGGDP  +T+FG  AG + VSL TLS Y
Sbjct: 172 GFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPY 231

Query: 269 SEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKN------ 322
           ++GL ++AI QSG ALS W +   P  + + +A+KVGC + D   M +CL+  +      
Sbjct: 232 NKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTL 291

Query: 323 -YKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKF-- 379
            YK  +     P  +++ F PVIDGD IP DP  L      ++Y  + G N  +G  F  
Sbjct: 292 AYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDY--IAGTNNMDGHIFAS 349

Query: 380 --VDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRR 437
             +  I      VT  DF   VS F        +G    + T       WA   + E ++
Sbjct: 350 IDMPAINKGNKKVTEEDFYKLVSEFT-----ITKGLRGAKTTFDVYTESWAQDPSQENKK 404

Query: 438 KTLVALFTDHQWVAPA-VATADLHAQYGS-PTYFYAFYHHCQSEMKPSWADSAHGDEVPY 495
           KT+V   TD  ++ P  +A A   A   S  TY Y F H  +  + P W  + H D++ Y
Sbjct: 405 KTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQY 464

Query: 496 VFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPN 537
           VFG P   PT      +   D  +S  ++ YWTNFAKTGDPN
Sbjct: 465 VFGKPFATPT-----GYRPQDRTVSKAMIAYWTNFAKTGDPN 501


>gi|33563374 carboxylesterase 3 [Homo sapiens]
          Length = 571

 Score =  283 bits (724), Expect = 5e-76
 Identities = 186/592 (31%), Positives = 289/592 (48%), Gaps = 59/592 (9%)

Query: 19  VMLNSNVLLWLTAL--AIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGV 76
           V + S VL+ +  L  A   T    +   P V+T  G++RG +  +       V  +LG+
Sbjct: 5   VRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDR-LVNVFLGI 63

Query: 77  PYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLM 136
           P+A PP G  RF  P P   W G+R+ +    +C Q ++  +    +L            
Sbjct: 64  PFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVL---------NGK 114

Query: 137 TYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNV 196
             +   +EDCL LN+Y P E       S +PVMV++HGG+ + G     DGS LA+YG+V
Sbjct: 115 QQIFSVSEDCLVLNVYSPAEVPA---GSGRPVMVWVHGGALITGAATSYDGSALAAYGDV 171

Query: 197 IVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAG 256
           +V+T+ YRLG+LGF STGD+ A GN G LD + ALRW++EN+  FGGD   VT+FG  AG
Sbjct: 172 VVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAG 231

Query: 257 ASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVE 316
            S +S L LS  + GLF +AI QSG   +   ++  P    + +A+ + C+     +MV+
Sbjct: 232 GSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQ 291

Query: 317 CLRNKNYKELI-----QQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGV 371
           CL+ K  +EL+     + TI P T        +DG V P  P+ L+++  F +   ++GV
Sbjct: 292 CLQQKEGEELVLSKKLKNTIYPLT--------VDGTVFPKSPKELLKEKPFHSVPFLMGV 343

Query: 372 NQGEGLKFVD---GIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWA 428
           N  E    +    G++D  + ++  D     +  + +L   PE   T+ +          
Sbjct: 344 NNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEY------LG 397

Query: 429 DKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQS--EMKPSWAD 486
              + + + +       D     P V+ +      GSP +FY F H   S  ++KP+W  
Sbjct: 398 SNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVK 457

Query: 487 SAHGDEVPYVFGIP--MIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPN-QPVPQD 543
           + HG E  +VFG P  M   + L     ++ +  LS  +M  WT+FA+TGDPN + +P  
Sbjct: 458 ADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALP-- 515

Query: 544 TKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVP 595
                          W ++N  +Q YL I   PR    +R   + FW E +P
Sbjct: 516 --------------PWPQFNQAEQ-YLEINPVPRAGQKFREAWMQFWSETLP 552


>gi|37622887 carboxylesterase 2 isoform 2 [Homo sapiens]
          Length = 607

 Score =  280 bits (717), Expect = 3e-75
 Identities = 185/573 (32%), Positives = 286/573 (49%), Gaps = 67/573 (11%)

Query: 31  ALAIKFTLIDSQAQ---YPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERR 87
           A  +   L+  Q Q    P+  T+ G++ G    +     G V+ +LG+P+A PP G  R
Sbjct: 78  ACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAG-VQTFLGIPFAKPPLGPLR 136

Query: 88  FQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQ-NEDC 146
           F PPEPP SW+G+R+ T   A+C         L D+  +         MT+  D  +EDC
Sbjct: 137 FAPPEPPESWSGVRDGTTHPAMC---------LQDLTAVESEFLSQFNMTFPSDSMSEDC 187

Query: 147 LYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLG 206
           LYL+IY P       + S  PVMV+IHGG+ + G  ++ DGS+LA+  NV+V+ I YRLG
Sbjct: 188 LYLSIYTPAHSH---EGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLG 244

Query: 207 ILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLS 266
           +LGF STGD+ A GN+G LDQ+ ALRW+++N+  FGG+P RVTIFG  AG + VS L +S
Sbjct: 245 VLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVS 304

Query: 267 HYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKEL 326
             S+GLF  AI++SG AL    +       + ++A+   C+ +D+  +V CLR K+ +E+
Sbjct: 305 PISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEI 364

Query: 327 IQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEG---LKFVDGI 383
           +        + +  G V+DG  +P  PQ L+   +F     ++GVN  E    +  V  I
Sbjct: 365 L---AINKPFKMIPG-VVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRI 420

Query: 384 VDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVAL 443
            D +  +       ++   +  L   P   D LRE          D  +P+T +     +
Sbjct: 421 YDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEY------IGDNGDPQTLQAQFQEM 474

Query: 444 FTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIG 503
             D  +V PA+  A       +P YFY F H      +PSW  +     +          
Sbjct: 475 MADSMFVIPALQVAHFQCS-RAPVYFYEFQH------QPSWLKNIRPPHM---------- 517

Query: 504 PTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPN-QPVPQDTKFIHTKPNRFEEVAWSKY 562
             +     F++ +  LS  +M YW NFA+ G+PN + +P                 W  +
Sbjct: 518 --KADHVKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPH----------------WPLF 559

Query: 563 NPKDQLYLHIGLKPRVRDHYRATKVAFWLELVP 595
           + ++Q YL + L+P V    +A ++ FW + +P
Sbjct: 560 DQEEQ-YLQLNLQPAVGRALKAHRLQFWKKALP 591


>gi|21450749 carboxylesterase 7 isoform 2 [Homo sapiens]
          Length = 525

 Score =  239 bits (610), Expect = 7e-63
 Identities = 176/571 (30%), Positives = 271/571 (47%), Gaps = 94/571 (16%)

Query: 27  LWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGER 86
           +W+ A   K       A+ P  NT  G I+G +  +    + PV  +LGVP+A+PP G  
Sbjct: 16  IWVLAAPTK----GPSAEGPQRNTRLGWIQGKQVTVLGSPV-PVNVFLGVPFAAPPLGSL 70

Query: 87  RFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDC 146
           RF  P+P S W  +R  T +  +C Q+ +   L   ML + +              +EDC
Sbjct: 71  RFTNPQPASPWDNLREATSYPNLCLQNSEWLLLDQHMLKVHYPKF---------GVSEDC 121

Query: 147 LYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLG 206
           LYLNIY P   D     SK PV+V+  GG++  G+ ++ DGS LA+Y +V+V+ + YRLG
Sbjct: 122 LYLNIYAPAHADT---GSKLPVLVWFPGGAFKTGSASIFDGSALAAYEDVLVVVVQYRLG 178

Query: 207 ILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLS 266
           I GF +T DQ A GN+   DQ+ AL W+++N+  FGGDP  VTIFG  AGA  VS L LS
Sbjct: 179 IFGFFTTWDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILS 238

Query: 267 HYSEGLFQKAIIQSGTALSSW--AVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYK 324
             ++GLF KAI++SG A+  +  A +Y+ ++  +++A   G N  D+  ++ CLR K  K
Sbjct: 239 PMAKGLFHKAIMESGVAIIPYLEAHDYEKSEDLQVVAHFCGNNASDSEALLRCLRTKPSK 298

Query: 325 ELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIV 384
           EL+  T++  T   +F  V+DG   P++P  L+ Q  F     ++GVN  E   F+  + 
Sbjct: 299 ELL--TLSQKTK--SFTRVVDGAFFPNEPLDLLSQKAFKAIPSIIGVNNHE-CGFLLPMK 353

Query: 385 DNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALF 444
           +  + ++ ++   ++ + + N+   P     L     F      DK +    R +L+ L 
Sbjct: 354 EAPEILSGSNKSLAL-HLIQNILHIPPQYLHLVANEYF-----HDKHSLTEIRDSLLDLL 407

Query: 445 TDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGP 504
            D  +V PA+ TA  H +                                        G 
Sbjct: 408 GDVFFVVPALITARYHRE----------------------------------------GA 427

Query: 505 TELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNP 564
           TE         + +LS  +M YW  FA+TG+PN                 +   W  YN 
Sbjct: 428 TE--------EEKLLSRKMMKYWATFARTGNPNGN---------------DLSLWPAYNL 464

Query: 565 KDQLYLHIGLKPRVRDHYRATKVAFWLELVP 595
            +Q YL + L   +    +  +V FW   +P
Sbjct: 465 TEQ-YLQLDLNMSLGQRLKEPRVDFWTSTIP 494


>gi|115529439 carboxylesterase 8 (putative) [Homo sapiens]
          Length = 491

 Score =  231 bits (588), Expect = 3e-60
 Identities = 139/370 (37%), Positives = 196/370 (52%), Gaps = 39/370 (10%)

Query: 25  VLLWLTALAI--KFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPP 82
           +L W   L +  +  L     + P V T YG ++G +  +      P++ +LGVP++ PP
Sbjct: 4   ILCWSLTLCLMAQTALGALHTKRPQVVTKYGTLQGKQMHVGKT---PIQVFLGVPFSRPP 60

Query: 83  TGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQ 142
            G  RF PPEPP  W GIR+ T +   C Q              W    L ++    +++
Sbjct: 61  LGILRFAPPEPPEPWKGIRDATTYPPGCLQES------------W--GQLASMYVSTRER 106

Query: 143 ------NEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNV 196
                 +EDCLYLN+Y P       Q    PVMV+  GG+++ G  +  +GS LA+   V
Sbjct: 107 YKWLRFSEDCLYLNVYAPARAPGDPQ---LPVMVWFPGGAFIVGAASSYEGSDLAAREKV 163

Query: 197 IVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAG 256
           +++ + +RLGI GFLST D  A+GN+GLLDQ+ ALRW++EN+ AFGGDP  VT+FG  AG
Sbjct: 164 VLVFLQHRLGIFGFLSTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAG 223

Query: 257 ASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVE 316
           A  +S L +S  + GLF +AI QSGTAL    +   P K  + +A   GCN   T  +V 
Sbjct: 224 AMSISGLMMSPLASGLFHRAISQSGTALFRLFITSNPLKVAKKVAHLAGCNHNSTQILVN 283

Query: 317 CLRN---------KNYKELIQQTI--TPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNY 365
           CLR           N    +Q      P     +  PV+DG VIPDDP +L+ QG+  + 
Sbjct: 284 CLRALSGTKVMRVSNKMRFLQLNFQRDPEEIIWSMSPVVDGVVIPDDPLVLLTQGKVSSV 343

Query: 366 DIMLGVNQGE 375
             +LGVN  E
Sbjct: 344 PYLLGVNNLE 353



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 26/75 (34%), Positives = 35/75 (46%), Gaps = 16/75 (21%)

Query: 519 LSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRV 578
           LS  +M YW NFA+TG+PN                     W +YN KD+ YL +    RV
Sbjct: 421 LSLQMMKYWANFARTGNPNDG---------------NLPCWPRYN-KDEKYLQLDFTTRV 464

Query: 579 RDHYRATKVAFWLEL 593
               +  K+AFW+ L
Sbjct: 465 GMKLKEKKMAFWMSL 479


>gi|55770862 thyroglobulin [Homo sapiens]
          Length = 2768

 Score =  193 bits (490), Expect = 6e-49
 Identities = 142/481 (29%), Positives = 233/481 (48%), Gaps = 45/481 (9%)

Query: 70   VEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFT 129
            V+Q+LGVPYA+PP  ERRFQ PEP  +WTG  + ++  A C Q                 
Sbjct: 2225 VDQFLGVPYAAPPLAERRFQAPEP-LNWTGSWDASKPRASCWQP---------------- 2267

Query: 130  ANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNM--IDG 187
                T  +     +EDCLYLN+++P      +      V+V+ H     E +     IDG
Sbjct: 2268 ---GTRTSTSPGVSEDCLYLNVFIP-----QNVAPNASVLVFFHNTMDREESEGWPAIDG 2319

Query: 188  SILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKR 247
            S LA+ GN+IV+T +YR+G+ GFLS+G     GN+GLLDQ+ AL W++ ++  FGGDP+R
Sbjct: 2320 SFLAAVGNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRR 2379

Query: 248  VTIFGSGAGASCVS--LLTLSHYSEGLFQKAIIQSGTALSSWAV-NYQPAKYTRI-LADK 303
            V++     GA   S  LLT    +  LF++A++  G+ALS  AV +++ A+   I LA +
Sbjct: 2380 VSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKE 2439

Query: 304  VGCNMLDTTDMVECLRNKNYKEL----IQQTITPATYHIAFGPVIDGDVIPDDPQILMEQ 359
            V C M  + ++V CLR K    L     +       +H  +GPVIDG  + + P   +++
Sbjct: 2440 VSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHY-WGPVIDGHFLREPPARALKR 2498

Query: 360  GEFLNYDIMLGVNQGEGL-KFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRE 418
              ++  D+++G +Q +GL      +   E+         +    + N  G  +    +  
Sbjct: 2499 SLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEA 2558

Query: 419  TIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQS 478
               + Y+     ++  +  + L     D+  + P +  A   A+      F   YH  ++
Sbjct: 2559 AATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVF--MYHAPEN 2616

Query: 479  EMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQ 538
                S    A   +V +  G+P       +   FS  +  LS  +M Y+++F ++G+PN 
Sbjct: 2617 YGHGSLELLA---DVQFALGLPFY---PAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNY 2670

Query: 539  P 539
            P
Sbjct: 2671 P 2671


>gi|169216018 PREDICTED: similar to hCG40360 [Homo sapiens]
          Length = 327

 Score =  155 bits (392), Expect = 1e-37
 Identities = 84/204 (41%), Positives = 127/204 (62%), Gaps = 6/204 (2%)

Query: 174 GGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRW 233
           GG++  G+ ++ DGS LA+Y +++V+ + YRLGI GF +T DQ A GN+   DQ+ AL W
Sbjct: 20  GGAFETGSASIFDGSSLAAYEDMLVVIVQYRLGIFGFFTTWDQHAPGNWAFKDQVAALSW 79

Query: 234 IEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSW--AVNY 291
           +++N+  FGGDP  VTIFG   GA  VS L LS  +EGLF KA+++SG A+  +  A +Y
Sbjct: 80  VQKNIEFFGGDPSSVTIFGESVGAISVSSLMLSPMAEGLFHKAVMESGVAIILYLKAHDY 139

Query: 292 QPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPD 351
           + ++  +++A   G N  D+   + CLR K+ KEL+  T++  T   AF  V+DG   P+
Sbjct: 140 EKSEDLQVVAQFCGYNASDSEAPLRCLRTKSSKELL--TLSQKTK--AFTQVVDGAFFPN 195

Query: 352 DPQILMEQGEFLNYDIMLGVNQGE 375
           +P  L+ Q  F     ++GVN  E
Sbjct: 196 EPLDLLSQKAFKAIPSIIGVNNPE 219


>gi|169215613 PREDICTED: similar to hCG40360 [Homo sapiens]
          Length = 327

 Score =  155 bits (392), Expect = 1e-37
 Identities = 84/204 (41%), Positives = 127/204 (62%), Gaps = 6/204 (2%)

Query: 174 GGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRW 233
           GG++  G+ ++ DGS LA+Y +++V+ + YRLGI GF +T DQ A GN+   DQ+ AL W
Sbjct: 20  GGAFETGSASIFDGSSLAAYEDMLVVIVQYRLGIFGFFTTWDQHAPGNWAFKDQVAALSW 79

Query: 234 IEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSW--AVNY 291
           +++N+  FGGDP  VTIFG   GA  VS L LS  +EGLF KA+++SG A+  +  A +Y
Sbjct: 80  VQKNIEFFGGDPSSVTIFGESVGAISVSSLILSPMAEGLFHKAVMESGVAIILYLKAHDY 139

Query: 292 QPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPD 351
           + ++  +++A   G N  D+   + CLR K+ KEL+  T++  T   AF  V+DG   P+
Sbjct: 140 EKSEDLQVVAQFCGYNASDSEAPLRCLRTKSSKELL--TLSQKTK--AFTQVVDGAFFPN 195

Query: 352 DPQILMEQGEFLNYDIMLGVNQGE 375
           +P  L+ Q  F     ++GVN  E
Sbjct: 196 EPLDLLSQKAFKAIPSIIGVNNPE 219


>gi|239752162 PREDICTED: similar to hCG40360 [Homo sapiens]
          Length = 131

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 39/84 (46%), Positives = 60/84 (71%)

Query: 168 VMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQ 227
           V+++  GG++  G+ ++ DGS LA+Y +++V+ + YRLGI GF +T DQ A GN+   DQ
Sbjct: 20  VLLWFPGGAFETGSASIFDGSSLAAYEDMLVVIVQYRLGIFGFFTTWDQHAPGNWAFKDQ 79

Query: 228 IQALRWIEENVGAFGGDPKRVTIF 251
           + AL W+++N+  FGGDP  VTIF
Sbjct: 80  VAALSWVQKNIEFFGGDPSSVTIF 103


>gi|11055976 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase
           6 [Homo sapiens]
          Length = 395

 Score = 34.3 bits (77), Expect = 0.48
 Identities = 23/86 (26%), Positives = 37/86 (43%), Gaps = 1/86 (1%)

Query: 559 WSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDM 618
           W+  +      LH+ ++  VR  +      F   L P   NL+++FQ+  +     PP  
Sbjct: 77  WTTLSQGSAATLHMAVRDLVRSVFLCDMDVFDAYL-PWRRNLSDLFQWAVSRALCSPPAC 135

Query: 619 TSFPYGTRRSPAKIWPTTKRPAITPA 644
           ++FP G   S A   P   R + T A
Sbjct: 136 SAFPRGAISSEAVCKPLCARQSFTLA 161


>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
          Length = 1011

 Score = 33.5 bits (75), Expect = 0.82
 Identities = 40/151 (26%), Positives = 58/151 (38%), Gaps = 10/151 (6%)

Query: 639 PAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYY 698
           P   P++ P HS   H   P    VL     DY+T  S + A  A     NI     L  
Sbjct: 744 PQFFPSSPPPHSPLSHGHIPS-AIVLPNATHDYNTSFSNSNAHKAEKKLQNI--DHPLTK 800

Query: 699 KKDKRRHETHRRPSPQRNTTNDIAHIQNEEIMSLQ--MKQLEHDHECESLQAHDTLRLTC 756
              KR    HRR    RNT ND+    N+   + +  M  ++  H+   L    ++    
Sbjct: 801 SSSKR---DHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVP 857

Query: 757 P--PDYTLTLRRSPDDIPLMTPNTITMIPNT 785
           P  P+   +L   P  +P  +P     +P T
Sbjct: 858 PKVPNREASLYSPPSTLPRNSPTKRVDVPTT 888


>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
          Length = 1073

 Score = 33.5 bits (75), Expect = 0.82
 Identities = 40/151 (26%), Positives = 58/151 (38%), Gaps = 10/151 (6%)

Query: 639 PAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYY 698
           P   P++ P HS   H   P    VL     DY+T  S + A  A     NI     L  
Sbjct: 806 PQFFPSSPPPHSPLSHGHIPS-AIVLPNATHDYNTSFSNSNAHKAEKKLQNI--DHPLTK 862

Query: 699 KKDKRRHETHRRPSPQRNTTNDIAHIQNEEIMSLQ--MKQLEHDHECESLQAHDTLRLTC 756
              KR    HRR    RNT ND+    N+   + +  M  ++  H+   L    ++    
Sbjct: 863 SSSKR---DHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVP 919

Query: 757 P--PDYTLTLRRSPDDIPLMTPNTITMIPNT 785
           P  P+   +L   P  +P  +P     +P T
Sbjct: 920 PKVPNREASLYSPPSTLPRNSPTKRVDVPTT 950


>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
          Length = 1017

 Score = 33.5 bits (75), Expect = 0.82
 Identities = 40/151 (26%), Positives = 58/151 (38%), Gaps = 10/151 (6%)

Query: 639 PAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYY 698
           P   P++ P HS   H   P    VL     DY+T  S + A  A     NI     L  
Sbjct: 750 PQFFPSSPPPHSPLSHGHIPS-AIVLPNATHDYNTSFSNSNAHKAEKKLQNI--DHPLTK 806

Query: 699 KKDKRRHETHRRPSPQRNTTNDIAHIQNEEIMSLQ--MKQLEHDHECESLQAHDTLRLTC 756
              KR    HRR    RNT ND+    N+   + +  M  ++  H+   L    ++    
Sbjct: 807 SSSKR---DHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVP 863

Query: 757 P--PDYTLTLRRSPDDIPLMTPNTITMIPNT 785
           P  P+   +L   P  +P  +P     +P T
Sbjct: 864 PKVPNREASLYSPPSTLPRNSPTKRVDVPTT 894


>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
          Length = 998

 Score = 33.5 bits (75), Expect = 0.82
 Identities = 40/151 (26%), Positives = 58/151 (38%), Gaps = 10/151 (6%)

Query: 639 PAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYY 698
           P   P++ P HS   H   P    VL     DY+T  S + A  A     NI     L  
Sbjct: 731 PQFFPSSPPPHSPLSHGHIPS-AIVLPNATHDYNTSFSNSNAHKAEKKLQNI--DHPLTK 787

Query: 699 KKDKRRHETHRRPSPQRNTTNDIAHIQNEEIMSLQ--MKQLEHDHECESLQAHDTLRLTC 756
              KR    HRR    RNT ND+    N+   + +  M  ++  H+   L    ++    
Sbjct: 788 SSSKR---DHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVP 844

Query: 757 P--PDYTLTLRRSPDDIPLMTPNTITMIPNT 785
           P  P+   +L   P  +P  +P     +P T
Sbjct: 845 PKVPNREASLYSPPSTLPRNSPTKRVDVPTT 875


>gi|10937869 survival of motor neuron 2, centromeric isoform d [Homo
           sapiens]
          Length = 294

 Score = 32.3 bits (72), Expect = 1.8
 Identities = 28/94 (29%), Positives = 39/94 (41%), Gaps = 16/94 (17%)

Query: 61  PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPP---SSW-----TGIRNTTQFAAVCPQ 112
           P+P   LGP +   G+ +  PP       PP PP   S W     +G         +CP 
Sbjct: 199 PMPGPRLGPGKP--GLKFNGPPPPP----PPPPPHLLSCWLPPFPSGPPIIPPPPPICPD 252

Query: 113 HLDERSLLHDMLPIWFTANLDT--LMTYVQDQNE 144
            LD+   L  ML  W+ +   T   M + Q+Q E
Sbjct: 253 SLDDADALGSMLISWYMSGYHTGYYMGFRQNQKE 286


>gi|4507091 survival of motor neuron 1, telomeric isoform d [Homo
           sapiens]
          Length = 294

 Score = 32.3 bits (72), Expect = 1.8
 Identities = 28/94 (29%), Positives = 39/94 (41%), Gaps = 16/94 (17%)

Query: 61  PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPP---SSW-----TGIRNTTQFAAVCPQ 112
           P+P   LGP +   G+ +  PP       PP PP   S W     +G         +CP 
Sbjct: 199 PMPGPRLGPGKP--GLKFNGPPPPP----PPPPPHLLSCWLPPFPSGPPIIPPPPPICPD 252

Query: 113 HLDERSLLHDMLPIWFTANLDT--LMTYVQDQNE 144
            LD+   L  ML  W+ +   T   M + Q+Q E
Sbjct: 253 SLDDADALGSMLISWYMSGYHTGYYMGFRQNQKE 286


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,690,555
Number of Sequences: 37866
Number of extensions: 1690819
Number of successful extensions: 4613
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 4138
Number of HSP's gapped (non-prelim): 401
length of query: 816
length of database: 18,247,518
effective HSP length: 111
effective length of query: 705
effective length of database: 14,044,392
effective search space: 9901296360
effective search space used: 9901296360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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