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Search of human proteins with 241896926
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|241896926 protein tyrosine phosphatase, receptor type, H
isoform 2 precursor [Homo sapiens]
(937 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|241896926 protein tyrosine phosphatase, receptor type, H isof... 1943 0.0
gi|241896924 protein tyrosine phosphatase, receptor type, H isof... 1847 0.0
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 362 e-100
gi|13677214 receptor-type protein tyrosine phosphatase O isoform... 290 4e-78
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 280 3e-75
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 280 3e-75
gi|4506323 receptor-type protein tyrosine phosphatase O isoform ... 279 8e-75
gi|13677222 receptor-type protein tyrosine phosphatase O isoform... 268 1e-71
gi|13677218 receptor-type protein tyrosine phosphatase O isoform... 268 1e-71
gi|13677220 receptor-type protein tyrosine phosphatase O isoform... 266 5e-71
gi|13677216 receptor-type protein tyrosine phosphatase O isoform... 266 5e-71
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 239 1e-62
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 239 1e-62
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 238 2e-62
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 237 3e-62
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 236 7e-62
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 236 7e-62
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 236 7e-62
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 236 7e-62
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 235 2e-61
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 232 1e-60
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 232 1e-60
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 232 1e-60
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 232 1e-60
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 232 1e-60
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 231 3e-60
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 224 2e-58
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 223 5e-58
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 223 6e-58
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 221 2e-57
>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform
2 precursor [Homo sapiens]
Length = 937
Score = 1943 bits (5033), Expect = 0.0
Identities = 937/937 (100%), Positives = 937/937 (100%)
Query: 1 MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN 60
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN
Sbjct: 1 MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN 60
Query: 61 SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN 120
SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN
Sbjct: 61 SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN 120
Query: 121 PVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEP 180
PVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEP
Sbjct: 121 PVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEP 180
Query: 181 GCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYT 240
GCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYT
Sbjct: 181 GCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYT 240
Query: 241 YWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAV 300
YWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAV
Sbjct: 241 YWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAV 300
Query: 301 TSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAG 360
TSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAG
Sbjct: 301 TSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAG 360
Query: 361 SLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVY 420
SLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVY
Sbjct: 361 SLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVY 420
Query: 421 WVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQS 480
WVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQS
Sbjct: 421 WVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQS 480
Query: 481 LCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSV 540
LCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSV
Sbjct: 481 LCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSV 540
Query: 541 LGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKR 600
LGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKR
Sbjct: 541 LGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKR 600
Query: 601 RNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMV 660
RNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMV
Sbjct: 601 RNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMV 660
Query: 661 ASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQ 720
ASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQ
Sbjct: 661 ASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQ 720
Query: 721 TVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENW 780
TVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENW
Sbjct: 721 TVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENW 780
Query: 781 TVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIV 840
TVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIV
Sbjct: 781 TVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIV 840
Query: 841 HCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR 900
HCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR
Sbjct: 841 HCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR 900
Query: 901 FLQQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV 937
FLQQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV
Sbjct: 901 FLQQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV 937
>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
precursor [Homo sapiens]
Length = 1115
Score = 1847 bits (4784), Expect = 0.0
Identities = 895/909 (98%), Positives = 896/909 (98%)
Query: 29 APNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDG 88
A NP RNL VE QTTSSISLSWEVPDG D QNS Y VQCTGDGG TETRNTT T VTVDG
Sbjct: 207 AHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDG 266
Query: 89 LGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQ 148
LGPGSLYTCSVWVEKDGVNSSV VT+ATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQ
Sbjct: 267 LGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQ 326
Query: 149 NSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAP 208
NSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAP
Sbjct: 327 NSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAP 386
Query: 209 NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLE 268
NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLE
Sbjct: 387 NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLE 446
Query: 269 PGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSY 328
PGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSY
Sbjct: 447 PGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSY 506
Query: 329 SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN 388
SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN
Sbjct: 507 SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN 566
Query: 389 EVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTN 448
EVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTN
Sbjct: 567 EVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTN 626
Query: 449 ETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIW 508
ETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIW
Sbjct: 627 ETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIW 686
Query: 509 SCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVV 568
SCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVV
Sbjct: 687 SCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVV 746
Query: 569 CHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFA 628
CHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFA
Sbjct: 747 CHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFA 806
Query: 629 DHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPI 688
DHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPI
Sbjct: 807 DHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPI 866
Query: 689 HEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGR 748
HEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGR
Sbjct: 867 HEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGR 926
Query: 749 VKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPD 808
VKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPD
Sbjct: 927 VKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPD 986
Query: 809 HGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLL 868
HGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLL
Sbjct: 987 HGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLL 1046
Query: 869 GPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVA 928
GPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVA
Sbjct: 1047 GPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVA 1106
Query: 929 AIQAHKLEV 937
AIQAHKLEV
Sbjct: 1107 AIQAHKLEV 1115
Score = 676 bits (1745), Expect = 0.0
Identities = 349/558 (62%), Positives = 400/558 (71%), Gaps = 18/558 (3%)
Query: 1 MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN 60
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN
Sbjct: 1 MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN 60
Query: 61 SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN 120
SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN
Sbjct: 61 SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN 120
Query: 121 PVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEP 180
PVRNL VEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVD LEP
Sbjct: 121 PVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEP 180
Query: 181 GCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYT 240
GCLY FS+WVGKNGINSSRETRNATTA NPVRNL +E QT SSI+L WEVPDG PQ+ T
Sbjct: 181 GCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNST 240
Query: 241 YWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAV 300
Y V+ TGDGG TETRNTT+T VT + L PG+LYT SVW EK+G S + V+ +T PN V
Sbjct: 241 YCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPV 300
Query: 301 TSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAG 360
+L+ + TNS+IAL W P GP + +Y V + +G T+ST+ T+IT+ LE G
Sbjct: 301 RNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG-GRAGTRSTAHTNITVDRLEPG 359
Query: 361 SLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVY 420
LY +VW +N + T A TAPN V +L ETQT +S+ L W+ P P+ Q Y Y
Sbjct: 360 CLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTY 419
Query: 421 WVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQS 480
WV++ G +T T T E LEPGTLY F+VWAE+N S Q+
Sbjct: 420 WVEYTGDGGG-----------TETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQN 468
Query: 481 LCASTYPDTVTITSCVSTSAGYGVNLIWSCPQG-GYEAFELEVG----GQRGSQDRSSCG 535
+ ST P+ VT S + L W+ PQG G ++ V G + +S+ G
Sbjct: 469 VSISTVPNAVTSLS-KQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSG 527
Query: 536 EAVSVLGLGPARSYPATI 553
+++ L Y T+
Sbjct: 528 TDITLKELEAGSLYHLTV 545
Score = 71.2 bits (173), Expect = 4e-12
Identities = 61/212 (28%), Positives = 90/212 (42%), Gaps = 19/212 (8%)
Query: 2 AGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNS 61
AG+ L VW + + T A APN +L ETQT +S+ L W+ P SQ
Sbjct: 537 AGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLY 596
Query: 62 NYWVQCTGDG-----------GTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSV 110
YWVQ G +T T T V+ L PG+LY +VW E++ V SS
Sbjct: 597 VYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASST 656
Query: 111 GTVTTATAPNPVR-NLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTA 169
++ +T P+ V V + L W P G + +E G G + RS+
Sbjct: 657 QSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQG---GYEAFELEVGGQRG-SQDRSSC 712
Query: 170 HTNITVDRLEPGCLY---VFSVWVGKNGINSS 198
++V L P Y + ++W G ++ S
Sbjct: 713 GEAVSVLGLGPARSYPATITTIWDGMKVVSHS 744
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 362 bits (929), Expect = e-100
Identities = 278/930 (29%), Positives = 424/930 (45%), Gaps = 86/930 (9%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG-GTTETRNTTATNVTVDG 88
P P + V +T+ I L+W D ++ + T +G G + TT ++ + G
Sbjct: 454 PVPVSDFRVTVVSTTEIGLAWSSHDA-----ESFQMHITQEGAGNSRVEITTNQSIIIGG 508
Query: 89 LGPGSLYTCSVWVEK--DGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPD 146
L PG+ Y C V K +G + TV T P+ V ++ V T + + L W+ PDG
Sbjct: 509 LFPGTKY-CFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGAS 567
Query: 147 PQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATT 206
+E T A IT+ L PG LY ++ + + + T
Sbjct: 568 EYVYHLVIESKHGSNHTSTYDKA---ITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYT 624
Query: 207 APNPVRNLHMETQTNSSIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETRNTTN---TSV 262
P+ V N+ + T T ++ L W+ D P Y +E G+ T+ T+ T
Sbjct: 625 RPSNVSNIDVSTNTTAA-TLSWQNFDDASPTYSYCLLIEKAGNSSNA-TQVVTDIGITDA 682
Query: 263 TAERLEPGTLYTFSVWAEKNGARGSRQ--NVSISTVPNAVTSLSKQDWTNS-TIALRWTA 319
T L PG+ YT ++A+ S + S T P ++ S + + L+WT
Sbjct: 683 TVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTC 742
Query: 320 PQGPG-----QSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHL---TVWAER 371
P G + S W + + T++T L + Y++ TV +
Sbjct: 743 PPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTY--LNFSTSYNISITTVSCGK 800
Query: 372 NEVRGYNSTLTAATAPNEVTDLQNETQTK-NSVMLWWKAPGDPHSQLYVYWV--QWASKG 428
N+ T T P N T NSV + + H + Y V G
Sbjct: 801 MAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAG 860
Query: 429 HPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPD 488
HP + Y E + G + + R + +QSL +
Sbjct: 861 HPS---------------ADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSL-SEVLKY 904
Query: 489 TVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARS 548
+ + + +T Y L P G Y A V G
Sbjct: 905 EIDVGNESTTLGYYNGKLE---PLGSYRA---------------------CVAGFTNITF 940
Query: 549 YPATITTIWDGMKVVSHS----VVCHTESAGVIAGAFVGIL---LFLILVGLLIFFLKRR 601
+P I VS S V + GVI GA G + L ++ VG IF+ K+R
Sbjct: 941 HPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKR 1000
Query: 602 NKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVA 661
K + + I E+F + +K + DSNCGFA++Y+ L LVG SQ + A
Sbjct: 1001 KDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAA 1060
Query: 662 SASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQT 721
+EN KNRY NVLPYD SRV L + DYINA++MPG S ++FIATQGPLP T
Sbjct: 1061 ELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT 1119
Query: 722 VGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWT 781
+ DFWR+VWE+ + ++MLT C+E GR KCE YWP Q +G + V + E V+ WT
Sbjct: 1120 LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWT 1178
Query: 782 VRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVH 841
+R+ + ++ ++ +RQFH+ +WPDHGVP + D L+ F ++R ++ Q+ P +VH
Sbjct: 1179 IRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVH 1238
Query: 842 CSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRF 901
CSAGVGRTGT IA+D L+ Q+++E + + V +R RPLMVQTE QYVFL+QC+L
Sbjct: 1239 CSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI 1298
Query: 902 LQQSAQAPAEKEVPYEDVENL-IYENVAAI 930
++ +Q ++ ++ Y++ + IYEN+A +
Sbjct: 1299 VR--SQKDSKVDLIYQNTTAMTIYENLAPV 1326
Score = 123 bits (309), Expect = 7e-28
Identities = 127/505 (25%), Positives = 199/505 (39%), Gaps = 36/505 (7%)
Query: 82 TNVTVDGLGPGSLYTCSVWVEK-DGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWE 140
T V + GL PG+ Y +V+ + +G + T V ++T + +S+ L W+
Sbjct: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWK 387
Query: 141 VPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRE 200
V D N TY + G+ + + + + L Y +V I +
Sbjct: 388 VSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPG 446
Query: 201 TRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGG-TETRNTTN 259
T P PV + + + + I L W D ++ + T +G G + TTN
Sbjct: 447 FLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE-----SFQMHITQEGAGNSRVEITTN 501
Query: 260 TSVTAERLEPGTLYTFSVWAE-KNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWT 318
S+ L PGT Y F + + NG G+ + V TVP+AV + T + + L W
Sbjct: 502 QSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWK 561
Query: 319 APQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYN 378
+P G S Y Y + V E ST ITL+ L G+LY++T+ E + V G
Sbjct: 562 SPDGA--SEYVYHL--VIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDP 617
Query: 379 STLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQA 438
++ T P+ V+++ T T + + W D S Y Y + G+ +
Sbjct: 618 NSTAQYTRPSNVSNIDVSTNTTAATLSWQNF--DDASPTYSYCLLIEKAGN-------SS 668
Query: 439 NWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQ----SLCASTYPDTVTITS 494
N + T V L PG+ Y ++A+ D S + S C T P ++
Sbjct: 669 NATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFC--TDPASMASFD 726
Query: 495 CVSTSAGYGVNLIWSCPQGGYEAFELEV--GGQRGSQDRSSCGE------AVSVLGLGPA 546
C + L W+CP G FELEV G + SC V L +
Sbjct: 727 CEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFS 786
Query: 547 RSYPATITTIWDGMKVVSHSVVCHT 571
SY +ITT+ G C T
Sbjct: 787 TSYNISITTVSCGKMAAPTRNTCTT 811
Score = 108 bits (271), Expect = 2e-23
Identities = 112/469 (23%), Positives = 195/469 (41%), Gaps = 39/469 (8%)
Query: 35 NLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSL 94
++T + +S++L W+V D S N Y + G+ ++ N + + GL +
Sbjct: 371 DVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTF 429
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
Y +V + + G + T P PV + V + + I L W D ++ +
Sbjct: 430 YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDA-----ESFQM 484
Query: 155 EYTGDG-GRAGTRSTAHTNITVDRLEPGCLYVFS-VWVGKNGINSSRETRNATTAPNPVR 212
T +G G + T + +I + L PG Y F V G NG + T T P+ V
Sbjct: 485 HITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVF 544
Query: 213 NLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTL 272
++H+ T + + L W+ PDG +Y Y + G T +T + ++T + L PGTL
Sbjct: 545 DIHVVYVTTTEMWLDWKSPDG--ASEYVYHLVIESKHGSNHT-STYDKAITLQGLIPGTL 601
Query: 273 YTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWV 332
Y ++ E + G + + T P+ V+++ TN+T A +YSY +
Sbjct: 602 YNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVS--TNTTAATLSWQNFDDASPTYSYCL 659
Query: 333 SWVREGMTDPRTQSTSG---TDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAAT 385
+ G + TQ + TD T+ EL GS Y + ++A+ + G S + T
Sbjct: 660 LIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGD--GIKSLEPGRKSFCT 717
Query: 386 APNEVTDLQNETQTKN-SVMLWWKAPGDPHS--QLYVYWVQWASKGHPRRGQDPQANWVN 442
P + E K +++L W P ++ +L V W + H +
Sbjct: 718 DPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATH-----------LE 766
Query: 443 QTSRTNETWYKVEA--LEPGTLYNFTV-WAERNDVASSTQSLCASTYPD 488
S N T Y+ E L T YN ++ +A+ T++ C + D
Sbjct: 767 SCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITD 815
Score = 64.3 bits (155), Expect = 5e-10
Identities = 115/508 (22%), Positives = 189/508 (37%), Gaps = 71/508 (13%)
Query: 68 TGDGGTTETRNTTATNVTVDGLGPGSLYT-CSVWVEKDGVNSSVGT-------------- 112
TG+ G T+ +T + +G G + T S E G N S+ T
Sbjct: 53 TGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQK 112
Query: 113 VTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH-- 170
++T P+PV ++ + + +++ LTW+ D + Y V++ + + T + H
Sbjct: 113 TPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYK-YVVKHKMENEK--TITVVHQP 169
Query: 171 -TNITVDRLEPGCLYVFSVWVG-KNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCW 228
NIT L P YVFS+ G N T P PV +L + AL W
Sbjct: 170 WCNIT--GLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSW 227
Query: 229 EVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVW-AEKNGARGS 287
+G + V G E + V L+PG Y + + + N +G
Sbjct: 228 SNGNG----TASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGD 283
Query: 288 RQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRT-QS 346
+ T S +T R +P P G DP + Q
Sbjct: 284 ----PLGTEGGLDAS--------NTERSRAGSPTAPVHDESLV-------GPVDPSSGQQ 324
Query: 347 TSGTDITLKELEAGSLYHLTVWAE-RNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVML 405
+ T++ L LE G+ Y+ TV+++ N G + T +V D+ + S+ L
Sbjct: 325 SRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTL 384
Query: 406 WWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNF 465
WK + S Y Y + A G+ +N +E + L T YN
Sbjct: 385 IWKVSDNESSSNYTYKIHVA-------GETDSSN-----LNVSEPRAVIPGLRSSTFYNI 432
Query: 466 TVWAERNDVASSTQSLCASTYPDTVT--ITSCVSTSAGYGVNLIWSCPQGGYEAFELEV- 522
TV D+ + L T P V+ + VST+ + L WS E+F++ +
Sbjct: 433 TVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTE---IGLAWSSHDA--ESFQMHIT 487
Query: 523 -GGQRGSQDRSSCGEAVSVLGLGPARSY 549
G S+ + +++ + GL P Y
Sbjct: 488 QEGAGNSRVEITTNQSIIIGGLFPGTKY 515
Score = 55.1 bits (131), Expect = 3e-07
Identities = 58/220 (26%), Positives = 91/220 (41%), Gaps = 12/220 (5%)
Query: 21 SWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTT 80
S T P+ ++ V TT+ + L W+ PDG + ++ T T +
Sbjct: 531 SRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKA 590
Query: 81 ATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWE 140
+T+ GL PG+LY ++ E D V + T P+ V N+ V T ++ L+W+
Sbjct: 591 ---ITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAA-TLSWQ 646
Query: 141 VPDGPDPQNS-TYGVEYTGDGGRAGTRST--AHTNITVDRLEPGCLYVFSVW--VGKNGI 195
D P S +E G+ A T T+ TV L PG Y ++ VG +GI
Sbjct: 647 NFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVG-DGI 705
Query: 196 NSSRETRNA-TTAPNPVRNLHME-TQTNSSIALCWEVPDG 233
S R + T P + + E ++ L W P G
Sbjct: 706 KSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPG 745
Score = 43.9 bits (102), Expect = 7e-04
Identities = 82/388 (21%), Positives = 152/388 (39%), Gaps = 44/388 (11%)
Query: 191 GKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGG 250
G NG + + + ++T P+PV ++ + + +++ L W+ D +Y Y V++ +
Sbjct: 102 GSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTA-ASEYKYVVKHKMENE 160
Query: 251 GTETR-NTTNTSVTAERLEPGTLYTFSVWAE-KNGARGSRQNVSISTVPNAVTSLSKQDW 308
T T + ++T L P T Y FS+ N G + + + T P V+ L
Sbjct: 161 KTITVVHQPWCNITG--LRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALT 218
Query: 309 TNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 368
AL W+ G G +S + + G + TQ S + + L+ G Y++ +
Sbjct: 219 GVRKAALSWS--NGNGTASCRVLLESI--GSHEELTQD-SRLQVNISGLKPGVQYNINPY 273
Query: 369 AERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDP-HSQLYVYWVQWASK 427
++ N T D N +++ +P P H + V V
Sbjct: 274 LLQS-----NKTKGDPLGTEGGLDASNTERSRAG------SPTAPVHDESLVGPVD---- 318
Query: 428 GHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAE-RNDVASSTQSLCASTY 486
P GQ ++ +T + LEPGT YN TV+++ N Q++ T
Sbjct: 319 --PSSGQ-----------QSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTN 365
Query: 487 PDTVTITSCVSTSAGYGVNLIWSCPQGGYEA---FELEVGGQRGSQDRSSCGEAVSVLGL 543
V + V+ SA + LIW + +++ V G+ S + + + GL
Sbjct: 366 AIQVFDVTAVNISA-TSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGL 424
Query: 544 GPARSYPATITTIWDGMKVVSHSVVCHT 571
+ Y T+ + ++ + HT
Sbjct: 425 RSSTFYNITVCPVLGDIEGTPGFLQVHT 452
>gi|13677214 receptor-type protein tyrosine phosphatase O isoform a
precursor [Homo sapiens]
Length = 1216
Score = 290 bits (742), Expect = 4e-78
Identities = 224/766 (29%), Positives = 343/766 (44%), Gaps = 69/766 (9%)
Query: 175 VDRLEPGCLYVFSVWVGKNG-INSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDG 233
++ L PG Y +++ K I + P +++L + +++ L W P
Sbjct: 496 IENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYL 555
Query: 234 PYPQDYTYWVEYTGDGGGTETRNT---------TNTSVTAERLEPGTLYTFSV----WAE 280
+ Y + Y T T SV L P Y F V W +
Sbjct: 556 GVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGD 615
Query: 281 KNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSW--VREG 338
+ +S T P A ++ ++ NS + + WT S+S + W V EG
Sbjct: 616 PELSCCDSSTISFITAPVA-PEITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEG 674
Query: 339 MTDPRTQSTSGTDITLKELEAGSLYHLTVWA--ERNEVRGYNSTLTAATAPNEVTDLQNE 396
+ T + L G +Y+L+V A ER + AP + N+
Sbjct: 675 KKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPAPPKSLFAVNK 734
Query: 397 TQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEA 456
TQT SV L W G + + + Q + Q+P A + + +
Sbjct: 735 TQT--SVTLLWVEEGV--ADFFEVFCQQVGSSQKTKLQEPVA--------VSSHVVTISS 782
Query: 457 LEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYE 516
L P T YN +V + +D S + ST +T V I S G
Sbjct: 783 LLPATAYNCSVTSFSHDSPSVPTFIAVSTM-----VTEMNPNVVVISVLAILSTLLIGLL 837
Query: 517 AFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGV 576
L + ++ Q CG V R + W S+
Sbjct: 838 LVTLIILRKKHLQMARECGAGTFVNFASLERD--GKLPYNW------RRSIF-------- 881
Query: 577 IAGAFVGILLFLILVG-LLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNE 635
AF+ +L + LL F++ +K +K +L + + +DF +++
Sbjct: 882 ---AFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTN-------PVQLDDFDAYIKDMA 931
Query: 636 RDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSD 695
+DS+ F+ ++++L L+G A N KNRY N+LPYD+SRV L ++EE G+D
Sbjct: 932 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 991
Query: 696 YINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYW 755
YINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT C E RVKC+HYW
Sbjct: 992 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 1051
Query: 756 PLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVP--S 813
P +P +G + V ++ EE ++W R + +E + V F+Y AWPDHGVP +
Sbjct: 1052 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHFNYTAWPDHGVPTAN 1109
Query: 814 SPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSF 873
+ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL+ ++ +
Sbjct: 1110 AAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGL 1167
Query: 874 VRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 919
V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 1168 VSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 1213
Score = 35.4 bits (80), Expect = 0.25
Identities = 44/205 (21%), Positives = 83/205 (40%), Gaps = 17/205 (8%)
Query: 107 NSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEY--TGDGGRAG 164
+S++ +T AP +T NS + ++W D + + + + +G +
Sbjct: 623 SSTISFITAPVAPE----ITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKI 678
Query: 165 TRSTAHTNIT-VDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSS 223
+S +T + L PG +Y SV +++ R P P ++L +T +S
Sbjct: 679 KKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPAPPKSLFAVNKTQTS 738
Query: 224 IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTS---VTAERLEPGTLYTFSVWAE 280
+ L W V +G + + + G T+ + S VT L P T Y SV +
Sbjct: 739 VTLLW-VEEG-VADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSF 796
Query: 281 KNGARGSRQNVSISTV-----PNAV 300
+ + +++ST+ PN V
Sbjct: 797 SHDSPSVPTFIAVSTMVTEMNPNVV 821
Score = 32.0 bits (71), Expect = 2.8
Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 8/98 (8%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN---VTV 86
P P ++L +T +S++L W V +G+ + + Q G T+ + A + VT+
Sbjct: 723 PAPPKSLFAVNKTQTSVTLLW-VEEGV-ADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI 780
Query: 87 DGLGPGSLYTCSVWV---EKDGVNSSVGTVTTATAPNP 121
L P + Y CSV + V + + T T NP
Sbjct: 781 SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNP 818
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 280 bits (717), Expect = 3e-75
Identities = 152/372 (40%), Positives = 217/372 (58%), Gaps = 24/372 (6%)
Query: 575 GVIAGAFVGILLFLILVGLLIFFLKRRNKKK-QQKPELR-----------DLVFSSPGD- 621
G I G G+ L +LV ++ + R+ +++P R L G+
Sbjct: 1836 GAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNR 1895
Query: 622 -----IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVL 676
I F H K + DSN + +Y++L VG +QS +A EN KNRY N+L
Sbjct: 1896 KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNIL 1955
Query: 677 PYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHT 736
PYD +RV L + ++P SDYINAS++PG +E+I TQGPLP T DFW++VWEQ H
Sbjct: 1956 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 2015
Query: 737 LVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE-QKT 795
+VM+T C+E GRVKC+HYWP D +G L + ++ E V+ WT+RE + E+
Sbjct: 2016 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 2075
Query: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
+R FHY WPDHGVP + +L+ F R +R +++++ GP +VHCSAGVGRTGT IAL
Sbjct: 2076 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 2135
Query: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVP 915
D +L+QL S+ + + V +R R MVQTE QYV+LHQC+ R + ++ + +E+E P
Sbjct: 2136 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV-RDVLRARKLRSEQENP 2194
Query: 916 YEDVENLIYENV 927
IYENV
Sbjct: 2195 LFP----IYENV 2202
Score = 77.0 bits (188), Expect = 8e-14
Identities = 105/468 (22%), Positives = 185/468 (39%), Gaps = 45/468 (9%)
Query: 112 TVTTATAPNPVRNLTV--EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG-----GRAG 164
TV T P P V E T++S+ + W G + ++Y V+ + G
Sbjct: 321 TVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQI 377
Query: 165 TRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSI 224
ST+ T L G Y ++ G S N +T P+PV+++ + T+ N S+
Sbjct: 378 QESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SL 436
Query: 225 ALCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNTTNTSVTAERLEPGTLYTFSVWAE 280
+ W G + Y + G GG ++ TS L PG LY +V E
Sbjct: 437 LISWSHGSGNVER---YRLMLMDKGILVHGGVVDKHA--TSYAFHGLTPGYLYNLTVMTE 491
Query: 281 KNGARGSRQNVSISTVPNAVTSLS-KQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGM 339
G + R + + T P V++L D + +++ ++W P G SY+ +S + +
Sbjct: 492 AAGLQNYRWKL-VRTAPMEVSNLKVTNDGSLTSLKVKWQRPPG-NVDSYNITLSH-KGTI 548
Query: 340 TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQ-NETQ 398
+ R + T+ KEL G LY +TV E+ + T P++V +L+ N
Sbjct: 549 KESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAV-GRTFPDKVANLEANNNG 607
Query: 399 TKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE--A 456
S+++ W P Q + + +N T ET Y ++
Sbjct: 608 RMRSLVVSWSPPAGDWEQYRILLF------------NDSVVLLNITVGKEETQYVMDDTG 655
Query: 457 LEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYE 516
L PG Y V E ++ +S + C + V + ++++W P +E
Sbjct: 656 LVPGRQYEVEVIVESGNLKNSER--CQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWE 713
Query: 517 AFELEVGGQ---RGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMK 561
+ + + + + S + + L P R Y AT+T+I +K
Sbjct: 714 KYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLK 761
Score = 69.7 bits (169), Expect = 1e-11
Identities = 125/555 (22%), Positives = 202/555 (36%), Gaps = 66/555 (11%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRN---TTATNVTV 86
P P ++LT+ ++T + ++W G + Y +Q + TAT
Sbjct: 1037 PEPVKDLTLRNRSTEDLHVTWS---GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRF 1093
Query: 87 DGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQ-TNSSIALTWEVPDGP 145
L PG Y V V S + T P+ V+N+ + S+ + W P G
Sbjct: 1094 TSLTPGRQYKILVLTISGDVQQSA-FIEGFTVPSAVKNIHISPNGATDSLTVNW-TPGGG 1151
Query: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNAT 205
D + T + T T RLE G Y + +G ++
Sbjct: 1152 DVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI-ASVSGSLKNQINVVGR 1210
Query: 206 TAPNPVRNLHMETQTNS-SIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETRNTTNTSVT 263
T P V+ + + +S S+ + W+ G + D E G RNT+ + T
Sbjct: 1211 TVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE-----NGILLRNTSEPATT 1265
Query: 264 A----ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTA 319
E L PG Y + G TVP AVT L + + ++ RWTA
Sbjct: 1266 KQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTA 1325
Query: 320 PQGPGQSSYSYWV-----SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEV 374
+G S Y+ ++ + DP QS S + L G +Y + + E+
Sbjct: 1326 SEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFS-----FQNLLQGRMYKMVIVTHSGEL 1379
Query: 375 RGYNSTLTAATAPNEVTDLQ--NETQTKNSVMLWWKAPGD-PHSQLYVYWVQWASKGHPR 431
S + T P V+ L+ N T + W A GD +L +Y K
Sbjct: 1380 SN-ESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKK---- 1434
Query: 432 RGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVAS--STQSLCASTYPDT 489
NW ++ + T ++ + L PG Y V D+++ + +S A + P
Sbjct: 1435 ------ENWKDK----DLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSL 1484
Query: 490 VTITSCVSTSAGYGVNLIWSCPQG--GYEAFELE------VGGQRGSQDRSSCGEAVSVL 541
++ +TS + + W P Y FEL+ + +R S G V
Sbjct: 1485 MSFADIANTS----LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI--VY 1538
Query: 542 GLGPARSYPATITTI 556
GL P RSY + T+
Sbjct: 1539 GLRPGRSYQFNVKTV 1553
Score = 58.5 bits (140), Expect = 3e-08
Identities = 110/545 (20%), Positives = 205/545 (37%), Gaps = 36/545 (6%)
Query: 28 PAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG-----GTTETRNTTAT 82
P P ++ E T++S+ + W G + ++Y VQ + G +T+
Sbjct: 328 PLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQESTSWN 384
Query: 83 NVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVP 142
T L GS Y ++ G S +T P+PV+++ + + N S+ ++W
Sbjct: 385 EYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLLISWSHG 443
Query: 143 DGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETR 202
G + + + G G T+ L PG LY +V G+ + R +
Sbjct: 444 SG-NVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYR-WK 501
Query: 203 NATTAPNPVRNLHMETQTN-SSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTS 261
TAP V NL + + +S+ + W+ P G Y + + G + T
Sbjct: 502 LVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNV-DSYNITLSHKGTIKESRVLAPWITE 560
Query: 262 VTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSL-SKQDWTNSTIALRWTAP 320
+ L PG LY +V + V T P+ V +L + + ++ + W+ P
Sbjct: 561 THFKELVPGRLYQVTVSCVSGELSAQKMAVG-RTFPDKVANLEANNNGRMRSLVVSWSPP 619
Query: 321 QGPGQS--SYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYN 378
G + + S V +T + ++ D T L G Y + V E ++ +
Sbjct: 620 AGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDT--GLVPGRQYEVEVIVESGNLKN-S 676
Query: 379 STLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQA 438
T P V L+ + + S+ + W+ P ++ Y + A D
Sbjct: 677 ERCQGRTVPLAVLQLRVKHANETSLSIMWQT---PVAEWEKYIISLA---------DRDL 724
Query: 439 NWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVST 498
++++ + + L PG Y TV + D+ +S+ S+ T P VT +
Sbjct: 725 LLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSS-SVKGRTVPAQVTDLHVANQ 783
Query: 499 SAGYGVNLIWSCPQGGYEAFELEVGGQR---GSQDRSSCGEAVSVLGLGPARSYPATITT 555
+ W+ QG E +++ + + ++ SS S L Y +TT
Sbjct: 784 GMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTT 843
Query: 556 IWDGM 560
+ G+
Sbjct: 844 VSGGI 848
Score = 57.4 bits (137), Expect = 6e-08
Identities = 116/546 (21%), Positives = 194/546 (35%), Gaps = 63/546 (11%)
Query: 31 NPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETR--NTTATNVTVDG 88
N GRN +S+SW + G NY V + DG ++ + +
Sbjct: 871 NSGRN--------DYLSVSWLLAPG---DVDNYEVTLSHDGKVVQSLVIAKSVRECSFSS 919
Query: 89 LGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSS-IALTWEVPDGPDP 147
L PG LYT ++ + G + T P+ V+ ++V S + ++W G
Sbjct: 920 LTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFD 978
Query: 148 QNSTYGVEYTGDGGRAGTRST--AHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNAT 205
Y V T+S + +L PG LY +V K+G + E N
Sbjct: 979 H---YEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTT-KSGQYEANEQGNGR 1034
Query: 206 TAPNPVRNLHMETQTNSSIALCWEVPDGPYPQ--------DYTYWVEYTGDGGGTETRNT 257
T P PV++L + ++ + + W +G Q D + + TE R T
Sbjct: 1035 TIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFT 1094
Query: 258 TNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLS-KQDWTNSTIALR 316
+ L PG Y V + S + TVP+AV ++ + ++ +
Sbjct: 1095 S--------LTPGRQYKILVLTISGDVQQS-AFIEGFTVPSAVKNIHISPNGATDSLTVN 1145
Query: 317 WTAPQGPGQSSYSYWVSWVREGM-TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVR 375
WT P G SY+ VS R D +T + T LEAG Y + + + ++
Sbjct: 1146 WT-PGGGDVDSYT--VSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLK 1202
Query: 376 GYNSTLTAATAPNEVTDL--QNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRG 433
+ T P V + N + + ++ W KA G + + G R
Sbjct: 1203 N-QINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE---NGILLR- 1257
Query: 434 QDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTIT 493
N + +K E L PG Y + + S T P VT
Sbjct: 1258 --------NTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDL 1309
Query: 494 SCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGS-QDRSSCG---EAVSVLGLGPARSY 549
S + ++ W+ +G + + + G+ Q+R+ ++ S L R Y
Sbjct: 1310 RITENSTRH-LSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMY 1368
Query: 550 PATITT 555
I T
Sbjct: 1369 KMVIVT 1374
Score = 55.8 bits (133), Expect = 2e-07
Identities = 73/347 (21%), Positives = 132/347 (38%), Gaps = 32/347 (9%)
Query: 220 TNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETR-NTTNTSVTAERLEPGTLYTFSVW 278
++ S+++ W + P Y + G R + T + L+ GT+Y F +
Sbjct: 255 SSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRII 314
Query: 279 AEKNGARGSRQNVSIST--VPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVR 336
+ + V + T +P A +SK+ T++++ + WT G SY V
Sbjct: 315 S-----LDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFD 366
Query: 337 EGMTDPR----TQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTD 392
E + +STS + T L AGS Y++ + A R ++ +T P+ V D
Sbjct: 367 ENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKD 426
Query: 393 LQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWY 452
+ T+ + ++ W G+ Y + KG G + T Y
Sbjct: 427 IGISTKANSLLISWSHGSGNVER----YRLMLMDKGILVHG---------GVVDKHATSY 473
Query: 453 KVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQ 512
L PG LYN TV E + + L T P V+ + + + + W P
Sbjct: 474 AFHGLTPGYLYNLTVMTEAAGLQNYRWKL-VRTAPMEVSNLKVTNDGSLTSLKVKWQRPP 532
Query: 513 GGYEAFELEV---GGQRGSQDRSSCGEAVSVLGLGPARSYPATITTI 556
G +++ + + G + S+ + L P R Y T++ +
Sbjct: 533 GNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCV 579
Score = 54.7 bits (130), Expect = 4e-07
Identities = 97/527 (18%), Positives = 198/527 (37%), Gaps = 41/527 (7%)
Query: 55 GLDSQNSNYWVQCTGDGG-------------TTETRNTTATNVTVDGLGPGSLYTCSVWV 101
G+ S W Q GD E+ ++ + + L GSLY+ V
Sbjct: 784 GMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTT 843
Query: 102 EKDGVNSSVGTVTTATAPNPVRNLTV-EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
G++S V T P+ V +TV + N ++++W + G D N + + G
Sbjct: 844 VSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPG-DVDNYEVTLSHDGKV 902
Query: 161 GRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQT 220
++ + + + L PG LY ++ ++G + T P+ V+ + +
Sbjct: 903 VQSLVIAKSVRECSFSSLTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSA 961
Query: 221 NSS-IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWA 279
S + + W G + Y ++ + T++ + +L PG LY+ +V
Sbjct: 962 RSDYLRVSWVHATGDF-DHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTV-T 1019
Query: 280 EKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGM 339
K+G + + + T+P V L+ ++ + + + W+ G Y + + +
Sbjct: 1020 TKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANG-DVDQYEIQLLFNDMKV 1078
Query: 340 TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQ- 398
P + T+ L G Y + V +V+ ++ + T P+ V ++
Sbjct: 1079 FPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQ-QSAFIEGFTVPSAVKNIHISPNG 1137
Query: 399 -TKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEAL 457
T + + W GD S Y V ++ H ++ +QT + + L
Sbjct: 1138 ATDSLTVNWTPGGGDVDS----YTV--SAFRHSQKVD-------SQTIPKHVFEHTFHRL 1184
Query: 458 EPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEA 517
E G Y + A + + ++ T P +V + + Y + + W G E
Sbjct: 1185 EAGEQYQIMI-ASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAER 1243
Query: 518 FELEVGGQRGSQDRSSCGEAVS----VLGLGPARSYPATITTIWDGM 560
+++ + + G R++ A + L P + Y I T+ G+
Sbjct: 1244 YDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGL 1290
Score = 45.1 bits (105), Expect = 3e-04
Identities = 52/208 (25%), Positives = 84/208 (40%), Gaps = 25/208 (12%)
Query: 42 TTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT---VDGLGPGSLYTCS 98
TT S+ +W G + +++ + T+ N ++T GL PG Y
Sbjct: 1404 TTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLW 1459
Query: 99 VWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 158
V +++ V T + TAP+P ++ N+S+A+TW+ GP E
Sbjct: 1460 VVTHSGDLSNKV-TAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFELQW 1515
Query: 159 DGGRAGTRSTAHTNIT-----VDRLEPGCLYVFSVWVGKNGINSSRETRN------ATTA 207
A T + N V L PG Y F+V K S +T + T
Sbjct: 1516 LPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSVRTK 1572
Query: 208 PNPVRNLHMETQTNSSIALCWEVPDGPY 235
P+ ++NLH Q +++IA W PD +
Sbjct: 1573 PDKIQNLHCRPQNSTAIACSWIPPDSDF 1600
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 280 bits (717), Expect = 3e-75
Identities = 152/372 (40%), Positives = 217/372 (58%), Gaps = 24/372 (6%)
Query: 575 GVIAGAFVGILLFLILVGLLIFFLKRRNKKK-QQKPELR-----------DLVFSSPGD- 621
G I G G+ L +LV ++ + R+ +++P R L G+
Sbjct: 1618 GAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNR 1677
Query: 622 -----IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVL 676
I F H K + DSN + +Y++L VG +QS +A EN KNRY N+L
Sbjct: 1678 KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNIL 1737
Query: 677 PYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHT 736
PYD +RV L + ++P SDYINAS++PG +E+I TQGPLP T DFW++VWEQ H
Sbjct: 1738 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 1797
Query: 737 LVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE-QKT 795
+VM+T C+E GRVKC+HYWP D +G L + ++ E V+ WT+RE + E+
Sbjct: 1798 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 1857
Query: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
+R FHY WPDHGVP + +L+ F R +R +++++ GP +VHCSAGVGRTGT IAL
Sbjct: 1858 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 1917
Query: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVP 915
D +L+QL S+ + + V +R R MVQTE QYV+LHQC+ R + ++ + +E+E P
Sbjct: 1918 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV-RDVLRARKLRSEQENP 1976
Query: 916 YEDVENLIYENV 927
IYENV
Sbjct: 1977 LFP----IYENV 1984
Score = 81.3 bits (199), Expect = 4e-15
Identities = 128/580 (22%), Positives = 222/580 (38%), Gaps = 56/580 (9%)
Query: 1 MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN 60
M G GL +W L LL TG P L ++ S+S+ W + + +
Sbjct: 1 MLSHGAGLALWITLSLLQ----TGLAEPE-RCNFTLAESKASSHSVSIQWRILGSPCNFS 55
Query: 61 SNYWVQCTGDGGTTETR-NTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAP 119
Y G R + T + L G++Y + + D TV T P
Sbjct: 56 LIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRI-ISLDEER----TVVLQTDP 110
Query: 120 NPVRNLTV--EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG-----GRAGTRSTAHTN 172
P V E T++S+ + W G + ++Y V+ + G ST+
Sbjct: 111 LPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQESTSWNE 167
Query: 173 ITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPD 232
T L G Y ++ G S N +T P+PV+++ + T+ N S+ + W
Sbjct: 168 YTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLLISWSHGS 226
Query: 233 GPYPQDYTYWVEYTGDG----GGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSR 288
G + Y + G GG ++ TS L PG LY +V E G + R
Sbjct: 227 GNVER---YRLMLMDKGILVHGGVVDKHA--TSYAFHGLTPGYLYNLTVMTEAAGLQNYR 281
Query: 289 QNVSISTVPNAVTSLS-KQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQST 347
+ + T P V++L D + +++ ++W P G SY+ +S + + + R +
Sbjct: 282 WKL-VRTAPMEVSNLKVTNDGSLTSLKVKWQRPPG-NVDSYNITLSH-KGTIKESRVLAP 338
Query: 348 SGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQ-NETQTKNSVMLW 406
T+ KEL G LY +TV E+ + T P++V +L+ N S+++
Sbjct: 339 WITETHFKELVPGRLYQVTVSCVSGELSAQKMAV-GRTFPDKVANLEANNNGRMRSLVVS 397
Query: 407 WKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE--ALEPGTLYN 464
W P Q + + +N T ET Y ++ L PG Y
Sbjct: 398 WSPPAGDWEQYRILLF------------NDSVVLLNITVGKEETQYVMDDTGLVPGRQYE 445
Query: 465 FTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGG 524
V E ++ +S + C + V + ++++W P +E + + +
Sbjct: 446 VEVIVESGNLKNSER--CQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLAD 503
Query: 525 Q---RGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMK 561
+ + S + + L P R Y AT+T+I +K
Sbjct: 504 RDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLK 543
Score = 69.7 bits (169), Expect = 1e-11
Identities = 125/555 (22%), Positives = 202/555 (36%), Gaps = 66/555 (11%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRN---TTATNVTV 86
P P ++LT+ ++T + ++W G + Y +Q + TAT
Sbjct: 819 PEPVKDLTLRNRSTEDLHVTWS---GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRF 875
Query: 87 DGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQ-TNSSIALTWEVPDGP 145
L PG Y V V S + T P+ V+N+ + S+ + W P G
Sbjct: 876 TSLTPGRQYKILVLTISGDVQQSA-FIEGFTVPSAVKNIHISPNGATDSLTVNW-TPGGG 933
Query: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNAT 205
D + T + T T RLE G Y + +G ++
Sbjct: 934 DVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI-ASVSGSLKNQINVVGR 992
Query: 206 TAPNPVRNLHMETQTNS-SIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETRNTTNTSVT 263
T P V+ + + +S S+ + W+ G + D E G RNT+ + T
Sbjct: 993 TVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE-----NGILLRNTSEPATT 1047
Query: 264 A----ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTA 319
E L PG Y + G TVP AVT L + + ++ RWTA
Sbjct: 1048 KQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTA 1107
Query: 320 PQGPGQSSYSYWV-----SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEV 374
+G S Y+ ++ + DP QS S + L G +Y + + E+
Sbjct: 1108 SEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFS-----FQNLLQGRMYKMVIVTHSGEL 1161
Query: 375 RGYNSTLTAATAPNEVTDLQ--NETQTKNSVMLWWKAPGD-PHSQLYVYWVQWASKGHPR 431
S + T P V+ L+ N T + W A GD +L +Y K
Sbjct: 1162 SN-ESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKK---- 1216
Query: 432 RGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVAS--STQSLCASTYPDT 489
NW ++ + T ++ + L PG Y V D+++ + +S A + P
Sbjct: 1217 ------ENWKDK----DLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSL 1266
Query: 490 VTITSCVSTSAGYGVNLIWSCPQG--GYEAFELE------VGGQRGSQDRSSCGEAVSVL 541
++ +TS + + W P Y FEL+ + +R S G V
Sbjct: 1267 MSFADIANTS----LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI--VY 1320
Query: 542 GLGPARSYPATITTI 556
GL P RSY + T+
Sbjct: 1321 GLRPGRSYQFNVKTV 1335
Score = 57.4 bits (137), Expect = 6e-08
Identities = 116/546 (21%), Positives = 194/546 (35%), Gaps = 63/546 (11%)
Query: 31 NPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETR--NTTATNVTVDG 88
N GRN +S+SW + G NY V + DG ++ + +
Sbjct: 653 NSGRN--------DYLSVSWLLAPG---DVDNYEVTLSHDGKVVQSLVIAKSVRECSFSS 701
Query: 89 LGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSS-IALTWEVPDGPDP 147
L PG LYT ++ + G + T P+ V+ ++V S + ++W G
Sbjct: 702 LTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFD 760
Query: 148 QNSTYGVEYTGDGGRAGTRST--AHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNAT 205
Y V T+S + +L PG LY +V K+G + E N
Sbjct: 761 H---YEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTT-KSGQYEANEQGNGR 816
Query: 206 TAPNPVRNLHMETQTNSSIALCWEVPDGPYPQ--------DYTYWVEYTGDGGGTETRNT 257
T P PV++L + ++ + + W +G Q D + + TE R T
Sbjct: 817 TIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFT 876
Query: 258 TNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLS-KQDWTNSTIALR 316
+ L PG Y V + S + TVP+AV ++ + ++ +
Sbjct: 877 S--------LTPGRQYKILVLTISGDVQQS-AFIEGFTVPSAVKNIHISPNGATDSLTVN 927
Query: 317 WTAPQGPGQSSYSYWVSWVREGM-TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVR 375
WT P G SY+ VS R D +T + T LEAG Y + + + ++
Sbjct: 928 WT-PGGGDVDSYT--VSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLK 984
Query: 376 GYNSTLTAATAPNEVTDL--QNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRG 433
+ T P V + N + + ++ W KA G + + G R
Sbjct: 985 N-QINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE---NGILLR- 1039
Query: 434 QDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTIT 493
N + +K E L PG Y + + S T P VT
Sbjct: 1040 --------NTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDL 1091
Query: 494 SCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGS-QDRSSCG---EAVSVLGLGPARSY 549
S + ++ W+ +G + + + G+ Q+R+ ++ S L R Y
Sbjct: 1092 RITENSTRH-LSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMY 1150
Query: 550 PATITT 555
I T
Sbjct: 1151 KMVIVT 1156
Score = 54.7 bits (130), Expect = 4e-07
Identities = 97/527 (18%), Positives = 198/527 (37%), Gaps = 41/527 (7%)
Query: 55 GLDSQNSNYWVQCTGDGG-------------TTETRNTTATNVTVDGLGPGSLYTCSVWV 101
G+ S W Q GD E+ ++ + + L GSLY+ V
Sbjct: 566 GMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTT 625
Query: 102 EKDGVNSSVGTVTTATAPNPVRNLTV-EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
G++S V T P+ V +TV + N ++++W + G D N + + G
Sbjct: 626 VSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPG-DVDNYEVTLSHDGKV 684
Query: 161 GRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQT 220
++ + + + L PG LY ++ ++G + T P+ V+ + +
Sbjct: 685 VQSLVIAKSVRECSFSSLTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSA 743
Query: 221 NSS-IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWA 279
S + + W G + Y ++ + T++ + +L PG LY+ +V
Sbjct: 744 RSDYLRVSWVHATGDF-DHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTV-T 801
Query: 280 EKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGM 339
K+G + + + T+P V L+ ++ + + + W+ G Y + + +
Sbjct: 802 TKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANG-DVDQYEIQLLFNDMKV 860
Query: 340 TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQ- 398
P + T+ L G Y + V +V+ ++ + T P+ V ++
Sbjct: 861 FPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQ-QSAFIEGFTVPSAVKNIHISPNG 919
Query: 399 -TKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEAL 457
T + + W GD S Y V ++ H ++ +QT + + L
Sbjct: 920 ATDSLTVNWTPGGGDVDS----YTV--SAFRHSQKVD-------SQTIPKHVFEHTFHRL 966
Query: 458 EPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEA 517
E G Y + A + + ++ T P +V + + Y + + W G E
Sbjct: 967 EAGEQYQIMI-ASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAER 1025
Query: 518 FELEVGGQRGSQDRSSCGEAVS----VLGLGPARSYPATITTIWDGM 560
+++ + + G R++ A + L P + Y I T+ G+
Sbjct: 1026 YDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGL 1072
Score = 45.1 bits (105), Expect = 3e-04
Identities = 52/208 (25%), Positives = 84/208 (40%), Gaps = 25/208 (12%)
Query: 42 TTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT---VDGLGPGSLYTCS 98
TT S+ +W G + +++ + T+ N ++T GL PG Y
Sbjct: 1186 TTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLW 1241
Query: 99 VWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 158
V +++ V T + TAP+P ++ N+S+A+TW+ GP E
Sbjct: 1242 VVTHSGDLSNKV-TAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFELQW 1297
Query: 159 DGGRAGTRSTAHTNIT-----VDRLEPGCLYVFSVWVGKNGINSSRETRN------ATTA 207
A T + N V L PG Y F+V K S +T + T
Sbjct: 1298 LPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSVRTK 1354
Query: 208 PNPVRNLHMETQTNSSIALCWEVPDGPY 235
P+ ++NLH Q +++IA W PD +
Sbjct: 1355 PDKIQNLHCRPQNSTAIACSWIPPDSDF 1382
>gi|4506323 receptor-type protein tyrosine phosphatase O isoform b
precursor [Homo sapiens]
Length = 1188
Score = 279 bits (714), Expect = 8e-75
Identities = 214/715 (29%), Positives = 332/715 (46%), Gaps = 86/715 (12%)
Query: 265 ERLEPGTLYTFSVWAEKNGARGSRQN-VSISTVPNAVTSLSKQDWTNSTIALRWTAPQGP 323
E L PG Y ++ K G + V+ + VP + L + + L WT P
Sbjct: 497 ENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLG 556
Query: 324 GQSSY-------------SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTV--- 367
Y S W ++ T T S + + L Y+ V
Sbjct: 557 VFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTAS-----VRIANLLPAWYYNFRVTMV 611
Query: 368 -WAERNEVRGYNSTLTAATAP--NEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 424
W + +ST++ TAP E+T ++ + + + W D + + W
Sbjct: 612 TWGDPELSCCDSSTISFITAPVAPEITSVE---YFNSLLYISWTYGDDTTDLSHSRMLHW 668
Query: 425 ASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWA--ERNDVASSTQSL- 481
++ + S T + +L PG +YN +V A ER S + +
Sbjct: 669 MVVAEGKKKI--------KKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK 720
Query: 482 CASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVL 541
P ++ + TS V L+W +G + FE+ Q GS ++ E V+V
Sbjct: 721 LEPAPPKSLFAVNKTQTS----VTLLW-VEEGVADFFEVFCQ-QVGSSQKTKLQEPVAVS 774
Query: 542 G-------LGPARSYPATITTI-WDGMKV---VSHSVVCHTESAGVIAGAFVGILLFLIL 590
L PA +Y ++T+ D V ++ S + + V+ + + IL L++
Sbjct: 775 SHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLI 834
Query: 591 VGLLIFFLKRRNKKKQQKPELRDLVFSS------PGDIP------------------AED 626
LL+ + R K Q E F + G +P +D
Sbjct: 835 GLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDD 894
Query: 627 FADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLK 686
F +++ +DS+ F+ ++++L L+G A N KNRY N+LPYD+SRV L
Sbjct: 895 FDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLV 954
Query: 687 PIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEA 746
++EE G+DYINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT C E
Sbjct: 955 SMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK 1014
Query: 747 GRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAW 806
RVKC+HYWP +P +G + V ++ EE ++W R + +E + V F+Y AW
Sbjct: 1015 RRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHFNYTAW 1072
Query: 807 PDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQS 864
PDHGVP ++ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL+ ++
Sbjct: 1073 PDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRD 1130
Query: 865 EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 919
+ V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 1131 HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 1185
Score = 35.4 bits (80), Expect = 0.25
Identities = 44/205 (21%), Positives = 83/205 (40%), Gaps = 17/205 (8%)
Query: 107 NSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEY--TGDGGRAG 164
+S++ +T AP +T NS + ++W D + + + + +G +
Sbjct: 623 SSTISFITAPVAPE----ITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKI 678
Query: 165 TRSTAHTNIT-VDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSS 223
+S +T + L PG +Y SV +++ R P P ++L +T +S
Sbjct: 679 KKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPAPPKSLFAVNKTQTS 738
Query: 224 IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTS---VTAERLEPGTLYTFSVWAE 280
+ L W V +G + + + G T+ + S VT L P T Y SV +
Sbjct: 739 VTLLW-VEEG-VADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSF 796
Query: 281 KNGARGSRQNVSISTV-----PNAV 300
+ + +++ST+ PN V
Sbjct: 797 SHDSPSVPTFIAVSTMVTEMNPNVV 821
Score = 32.0 bits (71), Expect = 2.8
Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 8/98 (8%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN---VTV 86
P P ++L +T +S++L W V +G+ + + Q G T+ + A + VT+
Sbjct: 723 PAPPKSLFAVNKTQTSVTLLW-VEEGV-ADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI 780
Query: 87 DGLGPGSLYTCSVWV---EKDGVNSSVGTVTTATAPNP 121
L P + Y CSV + V + + T T NP
Sbjct: 781 SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNP 818
>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 268 bits (686), Expect = 1e-71
Identities = 137/329 (41%), Positives = 201/329 (61%), Gaps = 13/329 (3%)
Query: 593 LLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLV 652
LL F++ +K +K +L + + +DF +++ +DS+ F+ ++++L L+
Sbjct: 85 LLAFYINPWSKNGLKKRKLTN-------PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLI 137
Query: 653 GHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFI 712
G A N KNRY N+LPYD+SRV L ++EE G+DYINA+++PG SPQE+I
Sbjct: 138 GLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYI 197
Query: 713 ATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLV 772
ATQGPLP+T DFW++V +Q+S +VMLT C E RVKC+HYWP +P +G + V ++
Sbjct: 198 ATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMI 257
Query: 773 GEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVP--SSPDTLLAFWRMLRQWLD 830
EE ++W R + +E + V F+Y AWPDHGVP ++ +++L F M+RQ
Sbjct: 258 SEEEQDDWACRHFRINYADEMQ--DVMHFNYTAWPDHGVPTANAAESILQFVHMVRQ--Q 313
Query: 831 QTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQ 890
T GP I+HCSAGVGRTGT IALD LL+ ++ + V +MR R MVQTE Q
Sbjct: 314 ATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQ 373
Query: 891 YVFLHQCILRFLQQSAQAPAEKEVPYEDV 919
Y+F+HQC+ + Q +V YE+V
Sbjct: 374 YIFIHQCVQLMWMKKKQQFCISDVIYENV 402
>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 268 bits (686), Expect = 1e-71
Identities = 137/329 (41%), Positives = 201/329 (61%), Gaps = 13/329 (3%)
Query: 593 LLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLV 652
LL F++ +K +K +L + + +DF +++ +DS+ F+ ++++L L+
Sbjct: 85 LLAFYINPWSKNGLKKRKLTN-------PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLI 137
Query: 653 GHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFI 712
G A N KNRY N+LPYD+SRV L ++EE G+DYINA+++PG SPQE+I
Sbjct: 138 GLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYI 197
Query: 713 ATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLV 772
ATQGPLP+T DFW++V +Q+S +VMLT C E RVKC+HYWP +P +G + V ++
Sbjct: 198 ATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMI 257
Query: 773 GEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVP--SSPDTLLAFWRMLRQWLD 830
EE ++W R + +E + V F+Y AWPDHGVP ++ +++L F M+RQ
Sbjct: 258 SEEEQDDWACRHFRINYADEMQ--DVMHFNYTAWPDHGVPTANAAESILQFVHMVRQ--Q 313
Query: 831 QTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQ 890
T GP I+HCSAGVGRTGT IALD LL+ ++ + V +MR R MVQTE Q
Sbjct: 314 ATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQ 373
Query: 891 YVFLHQCILRFLQQSAQAPAEKEVPYEDV 919
Y+F+HQC+ + Q +V YE+V
Sbjct: 374 YIFIHQCVQLMWMKKKQQFCISDVIYENV 402
>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 266 bits (681), Expect = 5e-71
Identities = 131/300 (43%), Positives = 189/300 (63%), Gaps = 6/300 (2%)
Query: 622 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 681
+ +DF +++ +DS+ F+ ++++L L+G A N KNRY N+LPYD+S
Sbjct: 79 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
Query: 682 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 741
RV L ++EE G+DYINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT
Sbjct: 139 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
Query: 742 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 801
C E RVKC+HYWP +P +G + V ++ EE ++W R + +E + V F
Sbjct: 199 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHF 256
Query: 802 HYQAWPDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLL 859
+Y AWPDHGVP ++ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL
Sbjct: 257 NYTAWPDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLL 314
Query: 860 RQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 919
+ ++ + V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 374
>gi|13677216 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 266 bits (681), Expect = 5e-71
Identities = 131/300 (43%), Positives = 189/300 (63%), Gaps = 6/300 (2%)
Query: 622 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 681
+ +DF +++ +DS+ F+ ++++L L+G A N KNRY N+LPYD+S
Sbjct: 79 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
Query: 682 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 741
RV L ++EE G+DYINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT
Sbjct: 139 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
Query: 742 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 801
C E RVKC+HYWP +P +G + V ++ EE ++W R + +E + V F
Sbjct: 199 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHF 256
Query: 802 HYQAWPDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLL 859
+Y AWPDHGVP ++ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL
Sbjct: 257 NYTAWPDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLL 314
Query: 860 RQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 919
+ ++ + V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 374
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 239 bits (609), Expect = 1e-62
Identities = 129/346 (37%), Positives = 193/346 (55%), Gaps = 27/346 (7%)
Query: 577 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPE------------------LRDLVFSS 618
+ G + ++L +++V ++ F ++R K E +R L + +
Sbjct: 1264 VTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQT 1323
Query: 619 PG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYR 673
PG IP D AD++ + + + F+ +Y+ + G + ++ N KNRY
Sbjct: 1324 PGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID-PGQQFTWENSNLEVNKPKNRYA 1382
Query: 674 NVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQ 733
NV+ YD SRV L I PGSDYINA+++ G +IATQGPLP+T+GDFWR+VWEQ+
Sbjct: 1383 NVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQR 1442
Query: 734 SHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQ 793
+ T+VM+T E RVKC+ YWP T G ++VTL+ + +TVR L +
Sbjct: 1443 TATVVMMTRLEEKSRVKCDQYWPARGTE-TCGLIQVTLLDTVELATYTVRTFALHKSGSS 1501
Query: 794 KTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLI 853
+ +RQF + AWPDHGVP P +LAF R ++ ++ GP +VHCSAGVGRTG I
Sbjct: 1502 EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC--NPLDAGPMVVHCSAGVGRTGCFI 1559
Query: 854 ALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
+D +L +++ E + + V MR R MVQTE QYVF+H+ +L
Sbjct: 1560 VIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL 1605
Score = 196 bits (498), Expect = 8e-50
Identities = 104/287 (36%), Positives = 164/287 (57%), Gaps = 6/287 (2%)
Query: 621 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 675
++PA + H++K + +S +++ L S H+ + A+ N KNR N+
Sbjct: 1614 EVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNI 1673
Query: 676 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 735
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL ++ DFWR++WE S
Sbjct: 1674 MPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNST 1733
Query: 736 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 795
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1734 IIVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1792
Query: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
++RQF + WP+ GVP + + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1793 RTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITL 1852
Query: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 902
++L +++ EG++ F V+ +R RP MVQTE QY ++ L +L
Sbjct: 1853 SIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL 1899
Score = 83.6 bits (205), Expect = 8e-16
Identities = 125/532 (23%), Positives = 197/532 (37%), Gaps = 55/532 (10%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTG---DGGTTETRNTTATNVTV 86
P P +L V T +S++L+W+ G + Y +Q +G E T ++
Sbjct: 319 PKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSI 376
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAP-NPVRNLTVEAQTNSSIALTWEV 141
GL P S Y V + + + +V T AP +P R + + S++ + WE
Sbjct: 377 GGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP 436
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHTN-----ITVDRLEPGCLYVFSVW----VGK 192
P+ P+ Y V YT D R H TV L PG Y V VG
Sbjct: 437 PEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGD 496
Query: 193 NGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVP--DGPYPQDYTYWVEYTGDGG 250
+ + + + P + E ++++ I L W +P + + YW D
Sbjct: 497 GPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQ 556
Query: 251 GTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQ---- 306
T + T +S T E L+P TLY F + A + G + + S Q
Sbjct: 557 HKVTFDPT-SSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMC 615
Query: 307 -DWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHL 365
++T+ + W P ++ S E + D + D +E + L L
Sbjct: 616 VSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAV-DGEDRGRHVVDGISREHSSWDLVGL 674
Query: 366 TVWAE-RNEVR-------GYNSTLTAATAPNEVTD-----LQNETQTKNSVMLWWK--AP 410
W E R VR G S+ +V ++ E +V ++WK P
Sbjct: 675 EKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVP 734
Query: 411 GDPHSQLYVYWVQWA--SKGHPRR---GQD---PQANWVNQTSRTNETWYKVEALEPGTL 462
H Q+ Y V + G PR QD +A W + S ET + L P T
Sbjct: 735 SKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYET--TISGLTPETT 792
Query: 463 YNFTV--WAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQ 512
Y+ TV + + D A S + +T T +ST+A L W P+
Sbjct: 793 YSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPK 844
Score = 67.8 bits (164), Expect = 5e-11
Identities = 127/528 (24%), Positives = 193/528 (36%), Gaps = 76/528 (14%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + G+ + VT P P +L V T +S+ LTW+ G + YG+
Sbjct: 296 YTC-VAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGI 352
Query: 155 EYTGDGGRAGTR---STAHTNITVDRLEPGCLYVFSVW----VGKNGINSSRETRNATTA 207
+Y G + A T ++ L P Y F V +G+ + + R A
Sbjct: 353 QYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA 412
Query: 208 P-NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNT-TNTS 261
P +P R + + S++ + WE P+ P Y V YT D NT
Sbjct: 413 PSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLL 472
Query: 262 VTAERLEPGTLYTFSVWA-EKNGARGSRQNVSIST---VPNAVTSLSKQDWTNSTIALRW 317
T L PG Y+ V A G + + T VP + +++ I L W
Sbjct: 473 TTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSW 532
Query: 318 TAPQGPGQSSYS--YWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVR 375
P Y YW + + TS TL++L+ +LY + A +
Sbjct: 533 LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTS--SYTLEDLKPDTLYRFQLAARSDMGV 590
Query: 376 G-YNSTLTAATA-------PNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASK 427
G + T+ A TA P +V + + T + W P D + + Q++
Sbjct: 591 GVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR--VSWVPPPADSRNGVI---TQYSVA 645
Query: 428 GHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWA--------ERNDVASSTQ 479
G+D + V+ SR + +W V LE T Y V A E + V T
Sbjct: 646 YEAVDGEDRGRHVVDGISREHSSWDLV-GLEKWTEYRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 480 SLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQ--------GGYEA--FELEVGGQRG-- 527
S P V + ST+ V++ W P GY+ LE G RG
Sbjct: 705 EDVPSGPPRKVEVEPLNSTA----VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLP 760
Query: 528 ---------SQDRSSCGE--AVSVLGLGPARSYPATI---TTIWDGMK 561
+Q R E ++ GL P +Y T+ TT DG +
Sbjct: 761 IIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGAR 808
Score = 55.8 bits (133), Expect = 2e-07
Identities = 67/283 (23%), Positives = 111/283 (39%), Gaps = 21/283 (7%)
Query: 32 PGR-NLTVETQTTSSISLSWEVPDGLDSQNSNYWVQ-CTGDGGTTETRN--TTATNVTVD 87
PGR + + T ++ L W P L + Y +Q C D T + + TV
Sbjct: 821 PGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVT 880
Query: 88 GLGPGSLYTCSVWVEK-----DGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVP 142
GL G+ Y + + + + T + P +NL V T S+ L W+ P
Sbjct: 881 GLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPP 939
Query: 143 DGPDPQNS--TYGVEYTGDGGRAGTRS-TAHTNITVDRLEPGCLYVFSV--WVGKNG--I 195
+ +Y V + + ++ T T T+ L+P Y V W K +
Sbjct: 940 VLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPL 999
Query: 196 NSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETR 255
+ S ++R +N + +S+ L WEVPD Y + + Y G E
Sbjct: 1000 SPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDS-YKSAVPFKILYNGQ--SVEVD 1056
Query: 256 NTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPN 298
+ + A+ L+P T Y+F + + A G + VSI T P+
Sbjct: 1057 GHSMRKLIAD-LQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPD 1098
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 239 bits (609), Expect = 1e-62
Identities = 129/346 (37%), Positives = 193/346 (55%), Gaps = 27/346 (7%)
Query: 577 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPE------------------LRDLVFSS 618
+ G + ++L +++V ++ F ++R K E +R L + +
Sbjct: 1255 VTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQT 1314
Query: 619 PG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYR 673
PG IP D AD++ + + + F+ +Y+ + G + ++ N KNRY
Sbjct: 1315 PGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID-PGQQFTWENSNLEVNKPKNRYA 1373
Query: 674 NVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQ 733
NV+ YD SRV L I PGSDYINA+++ G +IATQGPLP+T+GDFWR+VWEQ+
Sbjct: 1374 NVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQR 1433
Query: 734 SHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQ 793
+ T+VM+T E RVKC+ YWP T G ++VTL+ + +TVR L +
Sbjct: 1434 TATVVMMTRLEEKSRVKCDQYWPARGTE-TCGLIQVTLLDTVELATYTVRTFALHKSGSS 1492
Query: 794 KTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLI 853
+ +RQF + AWPDHGVP P +LAF R ++ ++ GP +VHCSAGVGRTG I
Sbjct: 1493 EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC--NPLDAGPMVVHCSAGVGRTGCFI 1550
Query: 854 ALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
+D +L +++ E + + V MR R MVQTE QYVF+H+ +L
Sbjct: 1551 VIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL 1596
Score = 196 bits (498), Expect = 8e-50
Identities = 104/287 (36%), Positives = 164/287 (57%), Gaps = 6/287 (2%)
Query: 621 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 675
++PA + H++K + +S +++ L S H+ + A+ N KNR N+
Sbjct: 1605 EVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNI 1664
Query: 676 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 735
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL ++ DFWR++WE S
Sbjct: 1665 MPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNST 1724
Query: 736 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 795
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1725 IIVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1783
Query: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
++RQF + WP+ GVP + + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1784 RTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITL 1843
Query: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 902
++L +++ EG++ F V+ +R RP MVQTE QY ++ L +L
Sbjct: 1844 SIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL 1890
Score = 79.7 bits (195), Expect = 1e-14
Identities = 120/526 (22%), Positives = 192/526 (36%), Gaps = 52/526 (9%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTG---DGGTTETRNTTATNVTV 86
P P +L V T +S++L+W+ G + Y +Q +G E T ++
Sbjct: 319 PKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSI 376
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAP-NPVRNLTVEAQTNSSIALTWEV 141
GL P S Y V + + + +V T AP +P R + + S++ + WE
Sbjct: 377 GGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP 436
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHTN-----ITVDRLEPGCLYVFSVW----VGK 192
P+ P+ Y V YT D R H TV L PG Y V VG
Sbjct: 437 PEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGD 496
Query: 193 NGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVP--DGPYPQDYTYWVEYTGDGG 250
+ + + + P + E ++++ I L W +P + + YW D
Sbjct: 497 GPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQ 556
Query: 251 GTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQ---- 306
T + T +S T E L+P TLY F + A + G + + S Q
Sbjct: 557 HKVTFDPT-SSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMC 615
Query: 307 -DWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHL 365
++T+ + W P ++ S E + D + D +E + L L
Sbjct: 616 VSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAV-DGEDRGRHVVDGISREHSSWDLVGL 674
Query: 366 TVWAE-RNEVR-------GYNSTLTAATAPNEVTD-----LQNETQTKNSVMLWWK--AP 410
W E R VR G S+ +V ++ E +V ++WK P
Sbjct: 675 EKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVP 734
Query: 411 GDPHSQLYVYWVQWA--SKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTV- 467
H Q+ Y V + G PR Q + + T + L P T Y+ TV
Sbjct: 735 SKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETT-----ISGLTPETTYSVTVA 789
Query: 468 -WAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQ 512
+ + D A S + +T T +ST+A L W P+
Sbjct: 790 AYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPK 835
Score = 70.5 bits (171), Expect = 7e-12
Identities = 126/519 (24%), Positives = 193/519 (37%), Gaps = 67/519 (12%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + G+ + VT P P +L V T +S+ LTW+ G + YG+
Sbjct: 296 YTC-VAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGI 352
Query: 155 EYTGDGGRAGTR---STAHTNITVDRLEPGCLYVFSVW----VGKNGINSSRETRNATTA 207
+Y G + A T ++ L P Y F V +G+ + + R A
Sbjct: 353 QYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA 412
Query: 208 P-NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNT-TNTS 261
P +P R + + S++ + WE P+ P Y V YT D NT
Sbjct: 413 PSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLL 472
Query: 262 VTAERLEPGTLYTFSVWA-EKNGARGSRQNVSIST---VPNAVTSLSKQDWTNSTIALRW 317
T L PG Y+ V A G + + T VP + +++ I L W
Sbjct: 473 TTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSW 532
Query: 318 TAPQGPGQSSYS--YWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVR 375
P Y YW + + TS TL++L+ +LY + A +
Sbjct: 533 LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTS--SYTLEDLKPDTLYRFQLAARSDMGV 590
Query: 376 G-YNSTLTAATA-------PNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASK 427
G + T+ A TA P +V + + T + W P D + + Q++
Sbjct: 591 GVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR--VSWVPPPADSRNGVI---TQYSVA 645
Query: 428 GHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWA--------ERNDVASSTQ 479
G+D + V+ SR + +W V LE T Y V A E + V T
Sbjct: 646 YEAVDGEDRGRHVVDGISREHSSWDLV-GLEKWTEYRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 480 SLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQ--------GGYEA--FELEVGGQRG-- 527
S P V + ST+ V++ W P GY+ LE G RG
Sbjct: 705 EDVPSGPPRKVEVEPLNSTA----VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLP 760
Query: 528 -SQD-RSSCGEAVSVLGLGPARSYPATI---TTIWDGMK 561
QD + + ++ GL P +Y T+ TT DG +
Sbjct: 761 IIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGAR 799
Score = 55.8 bits (133), Expect = 2e-07
Identities = 67/283 (23%), Positives = 111/283 (39%), Gaps = 21/283 (7%)
Query: 32 PGR-NLTVETQTTSSISLSWEVPDGLDSQNSNYWVQ-CTGDGGTTETRN--TTATNVTVD 87
PGR + + T ++ L W P L + Y +Q C D T + + TV
Sbjct: 812 PGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVT 871
Query: 88 GLGPGSLYTCSVWVEK-----DGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVP 142
GL G+ Y + + + + T + P +NL V T S+ L W+ P
Sbjct: 872 GLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPP 930
Query: 143 DGPDPQNS--TYGVEYTGDGGRAGTRS-TAHTNITVDRLEPGCLYVFSV--WVGKNG--I 195
+ +Y V + + ++ T T T+ L+P Y V W K +
Sbjct: 931 VLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPL 990
Query: 196 NSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETR 255
+ S ++R +N + +S+ L WEVPD Y + + Y G E
Sbjct: 991 SPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDS-YKSAVPFKILYNGQ--SVEVD 1047
Query: 256 NTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPN 298
+ + A+ L+P T Y+F + + A G + VSI T P+
Sbjct: 1048 GHSMRKLIAD-LQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPD 1089
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 238 bits (607), Expect = 2e-62
Identities = 124/282 (43%), Positives = 172/282 (60%), Gaps = 5/282 (1%)
Query: 622 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 681
I + F HV + ++N F +++ +L S A N AKNR+ N+ PY+ +
Sbjct: 1983 ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNN 2042
Query: 682 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 741
RV L PGSDYINAS++ G P EFIATQGPLP TVGDFWR+VWE ++ TLVMLT
Sbjct: 2043 RVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLT 2102
Query: 742 NCMEAGRVKCEHYWPLDSQPCT-HGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQ 800
C E GR++C YWP D++P T G + +T + E+V +WT+R+L + ++VRQ
Sbjct: 2103 QCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQ 2160
Query: 801 FHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLR 860
++ AWP+HGVP + L+ F +++R + + P IVHCSAGVGRTG IALD L +
Sbjct: 2161 CNFTAWPEHGVPENSAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQ 2218
Query: 861 QLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 902
+ + + V ++R R MVQ AQY+FLHQCIL L
Sbjct: 2219 HINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL 2260
Score = 64.3 bits (155), Expect = 5e-10
Identities = 87/373 (23%), Positives = 136/373 (36%), Gaps = 84/373 (22%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNY---------WVQCTGDGGTTETRNTT 80
P P L E ++ I LSW P + + +Y W+Q T+ R+
Sbjct: 56 PGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTV----YTQVRSKP 111
Query: 81 -ATNVTVDGLGPGSLYTCSVWVEKD---GVNSSVGTVTTA-TAPNPVRNLTVEAQTNSSI 135
+ V + L PG+ Y V E GV S TA +AP V NLTVEA S++
Sbjct: 112 DSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAV 171
Query: 136 ALTWEVPDGPDPQNSTY--GVEYTGDG--------------------------------- 160
L W +P P+ + +++ V++ G
Sbjct: 172 KLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTA 231
Query: 161 ------GRAGTRS-TAHTNITVDR-----------------LEPGCLYVFSVWVG--KNG 194
GR S T H++ T+ + L P Y+F V + G
Sbjct: 232 SPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAG 291
Query: 195 INSSRETRNATTAP-NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTE 253
S R + P P +N T S ++ W+ P ++Y VE G G
Sbjct: 292 YIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWD-PPTIVTGKFSYRVELYGPSGRIL 350
Query: 254 TRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSIST---VPNAVTSLSKQDWTN 310
+T + L P T+Y + AE + G + N+S+ T VP AV L + +
Sbjct: 351 DNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVES 410
Query: 311 STIALRWTAPQGP 323
+ + + W P+ P
Sbjct: 411 TQVRITWKKPRQP 423
Score = 63.5 bits (153), Expect = 9e-10
Identities = 75/338 (22%), Positives = 140/338 (41%), Gaps = 20/338 (5%)
Query: 104 DGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTG-DGGR 162
+G + + T P+ ++ + + ++SSI L W+ P+ P+ + + Y + D R
Sbjct: 554 EGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR 613
Query: 163 AGTRSTAHTNITVDRLEPGCLYVF----SVWVGKNGINSSRETRNATTAPNPV---RNLH 215
A +T + + L+ Y S VG++ ++ + T+ P +++
Sbjct: 614 AFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVE 673
Query: 216 METQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTF 275
+ T I L W P+ P Y V Y +NT+ T + L P TLY
Sbjct: 674 VIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDT-LYMKNTSTTDIILRNLRPHTLYNI 732
Query: 276 SVWAEKNGARGSRQNVSIS-----TVP-NAVTSLSKQDWTNSTIALRWTAPQGPGQSSYS 329
SV + G++ + +S TVP +A +++ ++ ++ I L + P P
Sbjct: 733 SVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQK 792
Query: 330 YWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNST----LTAAT 385
Y + R + RT +T+ +K L+ + Y + V A + G S LT
Sbjct: 793 YTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEED 852
Query: 386 APNE-VTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWV 422
AP+ D + + +V L W+ P +P+ + Y V
Sbjct: 853 APDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTV 890
Score = 63.5 bits (153), Expect = 9e-10
Identities = 99/432 (22%), Positives = 173/432 (40%), Gaps = 43/432 (9%)
Query: 26 RAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN-V 84
R P+ + + + ++SSI L W+ P+ + + ++Y + + TT N
Sbjct: 565 RQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSF 624
Query: 85 TVDGLGPGSLYTCSVWVEKDGVNSSVGT-----VTTA-----TAPNPVRNLTVEAQTNSS 134
+ GL + Y V SS+ V T+ ++P V + V T
Sbjct: 625 LITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDV---TADE 681
Query: 135 IALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSV-----W 189
I L W P+ P+ Y V Y + ++T+ T+I + L P LY SV +
Sbjct: 682 IRLKWSPPEKPNGIIIAYEVLYK-NIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRF 740
Query: 190 VGKNGINSSRETRNATTAPNPV-RNLHMETQTNSSIALCWEVPDGP--YPQDYTYWVEYT 246
N ++S R + T P+ N+ + ++ I L + P P Q YT +++
Sbjct: 741 GHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLK-R 799
Query: 247 GDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQ-NVSISTVPNAVTS--- 302
+G T NTT+ + + L+ T Y V A G R +SI T +A S
Sbjct: 800 SNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQ 859
Query: 303 -LSKQDWTNSTIALRWTAPQGPGQSSYSYWV-SWVREGMTDPRTQSTSGTDITLKELEAG 360
S + + T+ L W P P Y V W R + +T + + T + L +L+
Sbjct: 860 DFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSL---KTINVTETSLELSDLDYN 916
Query: 361 SLYHLTVWAE--------RNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGD 412
Y V A R+ + + + A + P + D+ + +S++L+W P
Sbjct: 917 VEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPK--DVYYANLSSSSIILFWTPPSK 974
Query: 413 PHSQLYVYWVQW 424
P+ + Y V +
Sbjct: 975 PNGIIQYYSVYY 986
Score = 56.6 bits (135), Expect = 1e-07
Identities = 120/553 (21%), Positives = 206/553 (37%), Gaps = 73/553 (13%)
Query: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTAT 82
T P +P +++ V T I L W P+ + Y V T +NT+ T
Sbjct: 660 TSEDEPESSP-QDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNID-TLYMKNTSTT 717
Query: 83 NVTVDGLGPGSLYTCSV-----WVEKDGVNSSVGTVTTATAPNPV-RNLTVEAQTNSSIA 136
++ + L P +LY SV + + V+S + T+ T P+ N+T + ++ I
Sbjct: 718 DIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIE 777
Query: 137 LTWEVPDGPDPQNSTYGVEY-TGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGK--- 192
L++ P P+ Y + +G T +T + L+ Y+ V
Sbjct: 778 LSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKG 837
Query: 193 NGINSSR-ETRNATTAP-NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGG 250
G+ S+ AP +P ++ ++ + ++ L W+ P P Y+ Y +
Sbjct: 838 EGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEP-NGIILYYTVYVWNRS 896
Query: 251 GTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARG-SRQNVSISTVPNAVTSLSKQD-- 307
+T N T TS+ L+ Y+ V A G +R N+ P S +D
Sbjct: 897 SLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVY 956
Query: 308 ---WTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGT---DITLKEL--EA 359
++S+I L WT P P Y V + ++TSGT + TL E+ +
Sbjct: 957 YANLSSSSIILFWTPPSKPNGIIQYYSVYY----------RNTSGTFMQNFTLHEVTNDF 1006
Query: 360 GSLYHLTVWAERNEVRGYNSTLTAATAPNE--------------------VTDLQNETQT 399
++ T+ + Y LTA+T+ V +L E+ +
Sbjct: 1007 DNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESIS 1066
Query: 400 KNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEP 459
++ + W P P+ L Y+V + PR + P T E + LE
Sbjct: 1067 STAINVSWVPPAQPNG-LVFYYVSLILQQTPRHVRPPLV--------TYERSIYFDNLEK 1117
Query: 460 GTLY--NFTVWAERNDVASSTQSLCAST---YPDTVTITSCVSTSAGYGVNLIWS---CP 511
T Y T E+ + T L T P+T I + + V L W P
Sbjct: 1118 YTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKP 1177
Query: 512 QGGYEAFELEVGG 524
G +++L + G
Sbjct: 1178 NGAIISYDLTLQG 1190
Score = 53.9 bits (128), Expect = 7e-07
Identities = 60/257 (23%), Positives = 95/257 (36%), Gaps = 19/257 (7%)
Query: 168 TAHTNITVDRLEPGCLYVFSVWVGKNGINS--SRETRNATTAPNPVRNLHMETQTNSSIA 225
T+ T + V + PG Y ++ S +R T P P L E ++ I
Sbjct: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
Query: 226 LCWEVPDGPYPQDYTYWVEYTGDGGGTETRNT------TNTSVTAERLEPGTLYTFSVWA 279
L W P P + +Y V+Y +T T + V L PGT Y V A
Sbjct: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
Query: 280 EKNGARGSRQN----VSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQ--SSYSYWVS 333
E + G + + + P V +L+ + + S + L W P+ P +S+ V
Sbjct: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
Query: 334 WVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDL 393
R G+ +T K E +W+ + + TL T P+ T
Sbjct: 194 HARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASP----SPTLGRVTPPSRTTH- 248
Query: 394 QNETQTKNSVMLWWKAP 410
+ T T+N + WK P
Sbjct: 249 SSSTLTQNEISSVWKEP 265
Score = 52.0 bits (123), Expect = 3e-06
Identities = 122/513 (23%), Positives = 197/513 (38%), Gaps = 60/513 (11%)
Query: 31 NPGRNLTVETQTTSSISLSWEVPDGLDSQNSN-YWVQCTGDGGTTETRNTTATNVTVDGL 89
+P ++ +V+ + ++ LSW+ P L+ Y+ + + +T N T T++ + L
Sbjct: 856 SPPQDFSVKQLSGVTVKLSWQPP--LEPNGIILYYTVYVWNRSSLKTINVTETSLELSDL 913
Query: 90 GPGSLYTCSVWVEK---DGVNSS--VGTVTTATAPN-PVRNLTVEAQTNSSIALTWEVPD 143
Y+ V DG S + T AP+ P +++ ++SSI L W P
Sbjct: 914 DYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPS 973
Query: 144 GPDPQNSTYGVEYTGDGGRAGTRSTAH------TNITV----DRLEPGCLYVF----SVW 189
P+ Y V Y G T H N+TV D+L Y F S
Sbjct: 974 KPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTS 1033
Query: 190 VGKNGINSSRETRNATTAPNP---VRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYT 246
VG NG SS T P V NL E+ ++++I + W P P + Y+V
Sbjct: 1034 VG-NGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVF-YYVSLI 1091
Query: 247 GDGGGTETRN---TTNTSVTAERLEPGTLYTFSVW--AEKNGARGSRQNVSIST---VPN 298
R T S+ + LE T Y + EK + + I T VP
Sbjct: 1092 LQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE 1151
Query: 299 AVTSLSK-QDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKEL 357
++ ++ +++++ L W P P + SY +G + + TS I L+EL
Sbjct: 1152 TSPIINTFKNLSSTSVLLSWDPPVKPNGAIISY--DLTLQGPNENYSFITSDNYIILEEL 1209
Query: 358 EAGSLYHLTVWAERNEVRGYNSTL------TAATAPNEVTDLQNETQTKNSVMLWWKAPG 411
+LY A + G +S L + AP + L N T + V L W
Sbjct: 1210 SPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLIN--CTSDFVWLKWSPSP 1267
Query: 412 DPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYN-----FT 466
P + VY + K H + + N + E K+ LEP + Y+ FT
Sbjct: 1268 LPGGIVKVY----SFKIHEH--ETDTIYYKNISGFKTEA--KLVGLEPVSTYSIRVSAFT 1319
Query: 467 VWAERNDVASSTQSLCASTYPDTVTITSCVSTS 499
N ++ + + PD V C++TS
Sbjct: 1320 KVGNGNQFSNVVKFTTQESVPDVVQNMQCMATS 1352
Score = 50.8 bits (120), Expect = 6e-06
Identities = 50/189 (26%), Positives = 79/189 (41%), Gaps = 16/189 (8%)
Query: 257 TTNTSVTAERLEPGTLY--TFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIA 314
T+ T V + PGT Y T S + + +R + T P L+ + ++ I
Sbjct: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
Query: 315 LRWTAPQGPGQSSYSYWVS------WVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 368
L W P P SY V W++ T R++ S ++ L L G+ Y + V
Sbjct: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDS-LEVLLTNLNPGTTYEIKVA 132
Query: 369 AERNEVRGYNST----LTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 424
AE + G S TA +AP +V +L E ++V L W P P+ ++ + +
Sbjct: 133 AENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKI-- 190
Query: 425 ASKGHPRRG 433
S H R G
Sbjct: 191 -SVKHARSG 198
Score = 48.5 bits (114), Expect = 3e-05
Identities = 87/420 (20%), Positives = 145/420 (34%), Gaps = 75/420 (17%)
Query: 79 TTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTA--TAPNPVRNLTVEAQTNSSIA 136
T+ T V V + PG+ Y ++ S V + T T P P L E ++ I
Sbjct: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
Query: 137 LTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTA------HTNITVDRLEPGCLYVFSVWV 190
L+W P P+ + +Y V+Y T T + + L PG Y V
Sbjct: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
Query: 191 GKN-GINSSRET---RNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYT 246
+ GI + + A +AP V NL +E S++ L W +P P + ++ +
Sbjct: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
Query: 247 GDGGGTETR--------------------------NTTNTSVTAERLEPGTLYTF----- 275
G + +T + S T R+ P + T
Sbjct: 194 HARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTL 253
Query: 276 ------SVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIA-LRWTAPQGPGQ--- 325
SVW E + + + + ++ + +STI + P+GP Q
Sbjct: 254 TQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCV 313
Query: 326 ----SSYSYWVSW----VREGMTDPRTQ-----------STSGTDITLKELEAGSLYHLT 366
+ S+ + W + G R + ST L ++Y +
Sbjct: 314 TGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVY 373
Query: 367 VWAERNEVRGYNSTLTAAT---APNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQ 423
+ AE + G S ++ T P V DLQ V + WK P P+ + Y V+
Sbjct: 374 IAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVK 433
Score = 43.1 bits (100), Expect = 0.001
Identities = 74/307 (24%), Positives = 118/307 (38%), Gaps = 34/307 (11%)
Query: 37 TVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN-VTVDGLGPGSLY 95
T + +++S+ LSW+ P + +Y T G T+ N + ++ L P +LY
Sbjct: 1158 TFKNLSSTSVLLSWDPPVKPNGAIISY--DLTLQGPNENYSFITSDNYIILEELSPFTLY 1215
Query: 96 T--CSVWVEKD-GVNSSVGTVTTATAP-NPVRNLTVEAQTNSSIALTWEVPDGPDPQNST 151
+ + K G +S + T + P P +NLT+ T+ + L W P
Sbjct: 1216 SFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKV 1275
Query: 152 YGV---EYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVW----VGKNGINSSRETRNA 204
Y E+ D S T + LEP Y V VG NG S +
Sbjct: 1276 YSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVG-NGNQFSNVVKFT 1334
Query: 205 T--TAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTS- 261
T + P+ V+N+ + S+ + W+ P Y V T RN+T S
Sbjct: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV--------TVERNSTKVSP 1386
Query: 262 ----VTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAV----TSLSKQDWTNSTI 313
T +L T Y F V A + G +ST+P V T+++ D +++
Sbjct: 1387 QDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSA 1446
Query: 314 ALRWTAP 320
L W P
Sbjct: 1447 TLTWIRP 1453
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 237 bits (605), Expect = 3e-62
Identities = 118/278 (42%), Positives = 170/278 (61%), Gaps = 5/278 (1%)
Query: 622 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 681
I D H+ + + GF ++Y+ G S S VA +N AKNRY N++ YD S
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESF-FEGQSASWDVAKKDQNRAKNRYGNIIAYDHS 926
Query: 682 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 741
RV L+P+ ++P SDYINA+++ G P +IATQGP+ +TV DFWR++W++QS +VM+T
Sbjct: 927 RVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVT 986
Query: 742 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 801
N +E GRVKC YWP D++ +G +VT V E + + VR L + + V+QF
Sbjct: 987 NLVEVGRVKCYKYWPDDTE--VYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQF 1044
Query: 802 HYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQ 861
H+ WPDHGVP LL+F R ++ L GP +VHCSAG GRTG I +D++L
Sbjct: 1045 HFTGWPDHGVPYHATGLLSFIRRVK--LSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDM 1102
Query: 862 LQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
+ EG++ ++ V+ +R R MVQTE QY+F+H IL
Sbjct: 1103 AEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL 1140
Score = 125 bits (314), Expect = 2e-28
Identities = 87/287 (30%), Positives = 144/287 (50%), Gaps = 13/287 (4%)
Query: 627 FADHVRKNERDSNCGFADKYQQLSLVG---HSQSQMVASASENNAKNRYRNVLPYDWSRV 683
+ D +R + + ++ D++Q L+ V ++ +A N+ KNR+ ++LP D
Sbjct: 1159 YFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLP 1218
Query: 684 PLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNC 743
L I E S+YINA+ M P FI TQ PLP TV DFWRLV++ ++VML
Sbjct: 1219 FLITIDGE-SSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV 1277
Query: 744 -MEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVR--ELLLLQVEEQKTLSVRQ 800
+ G C YWP + +G ++V + + + R + L ++ L V+Q
Sbjct: 1278 DLSQG---CPQYWPEEGM-LRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQ 1333
Query: 801 FHYQAWPDH-GVPSSPDTLLAFWRMLRQWLDQTMEG-GPPIVHCSAGVGRTGTLIALDVL 858
F Y W H VP S + L + +W ++ EG G I+HC G GR+G A+ ++
Sbjct: 1334 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1393
Query: 859 LRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQS 905
+ ++ + ++ F V+ +R S+P MV+ QY F + L +L+ S
Sbjct: 1394 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS 1440
Score = 34.7 bits (78), Expect = 0.43
Identities = 31/124 (25%), Positives = 48/124 (38%), Gaps = 15/124 (12%)
Query: 387 PNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSR 446
P V LQ T +N + L WK P DP+ + Y + ++S R DP
Sbjct: 492 PVPVKSLQG-TSFENKIFLNWKEPLDPNGIITQYEISYSS----IRSFDPAVPVAGPPQT 546
Query: 447 TNETWYKVE----ALEPGTLYNFTVWAER------NDVASSTQSLCASTYPDTVTITSCV 496
+ W L PGT Y F + A + T ++ A T PD + + +
Sbjct: 547 VSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASL 606
Query: 497 STSA 500
+ +A
Sbjct: 607 NETA 610
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 236 bits (602), Expect = 7e-62
Identities = 128/345 (37%), Positives = 189/345 (54%), Gaps = 26/345 (7%)
Query: 577 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP-----------------ELRDLVFSSP 619
+ G + ++ + +V ++ + ++R + +K ELR L F +P
Sbjct: 1270 VVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP 1329
Query: 620 G-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRN 674
G IP + ADH+ + + + N F+ +Y+ + G + ++ N KNRY N
Sbjct: 1330 GMASHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYAN 1388
Query: 675 VLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQS 734
V+ YD SRV L I PGSDY+NA+++ G +IATQG LP+T GDFWR++WEQ+S
Sbjct: 1389 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1448
Query: 735 HTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK 794
T+VM+T E RVKC+ YWP THG ++VTL+ + + VR L + +
Sbjct: 1449 ATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRTFALYKNGSSE 1507
Query: 795 TLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIA 854
VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG I
Sbjct: 1508 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTGCFIV 1565
Query: 855 LDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
+D +L +++ E + + V MR R MVQTE QY+F+H +L
Sbjct: 1566 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1610
Score = 199 bits (507), Expect = 8e-51
Identities = 107/287 (37%), Positives = 167/287 (58%), Gaps = 6/287 (2%)
Query: 621 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 675
++PA + +++K + ++ G ++++L S H+ + A+ N KNR N+
Sbjct: 1619 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1678
Query: 676 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 735
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL +T DFWR++WE S
Sbjct: 1679 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1738
Query: 736 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 795
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1739 IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1797
Query: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
+VRQF + WP+ GVP S + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1798 RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITL 1857
Query: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 902
++L +++ EG++ F V+ +R RP MVQTE QY F ++ L +L
Sbjct: 1858 SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1904
Score = 80.5 bits (197), Expect = 7e-15
Identities = 117/502 (23%), Positives = 190/502 (37%), Gaps = 50/502 (9%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGT---TETRNTTATNVTV 86
P P V T +SI+L+W+ G S Y +Q E T +V
Sbjct: 323 PKPPGTPVVTESTATSITLTWD--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSV 380
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPV-RNLTVEAQTNSSIALTWEV 141
GL P S Y V + + + V T T+ AP+ R++ ++++I + W+
Sbjct: 381 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDRLEPGCLYVFSVW----VGK 192
P+ P+ Q Y V YT D + H T+ L P Y V +G
Sbjct: 441 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 500
Query: 193 NGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGT 252
++S + T P N E ++ +SI L W P +Y + Y G
Sbjct: 501 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE--LVYKDGEHGE 558
Query: 253 ETRNT--TNTSVTAERLEPGTLYTFSVWAEK-NGARGSRQNVSISTVPNAVTS----LSK 305
E R T TS + L+P +LY F + A G S +S T+ + ++ +S
Sbjct: 559 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 618
Query: 306 QDWTNSTIALRWTAPQGPGQSSY--SYWVSWVREGMTDPRTQSTSG-----TDITLKELE 358
++++I + W P Q+ Y + + D + G T L++LE
Sbjct: 619 TSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLE 678
Query: 359 AGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTD-----LQNETQTKNSVMLWWKA--PG 411
+ Y +TV A + G S +V ++ E SV + W++ P
Sbjct: 679 KWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN 738
Query: 412 DPHSQLYVYWVQWA------SKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNF 465
H Q+ Y V + KG P A+ + T E + L+P T Y+
Sbjct: 739 KQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSL 798
Query: 466 TV--WAERNDVASSTQSLCAST 485
TV + + D A S L ++T
Sbjct: 799 TVTAYTTKGDGARSKPKLVSTT 820
Score = 68.6 bits (166), Expect = 3e-11
Identities = 104/448 (23%), Positives = 182/448 (40%), Gaps = 43/448 (9%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + GV ++ +T P P V T +SI LTW+ P+P S Y +
Sbjct: 300 YTC-VAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPV-SYYII 356
Query: 155 EYTGDGGRAGTR---STAHTNITVDRLEPGCLYVFSVW----VGKNGINSSRETRNATTA 207
++ + A T +V L P Y F V +G+ + T+ + A
Sbjct: 357 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA 416
Query: 208 PNPV-RNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNTTNTSV 262
P+ R++ ++++I + W+ P+ P Q Y V YT D N ++ +
Sbjct: 417 PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQI 476
Query: 263 TA-ERLEPGTLYTFSVWAEKNGARG----SRQNVSISTVPNAVTSLSKQDWTNSTIALRW 317
T L P Y+ V A + G Q ++ + VP + + + ++I L W
Sbjct: 477 TTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSW 536
Query: 318 TAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGY 377
T P+ ++Y G + R GT L+ L+ SLY+ + A + G
Sbjct: 537 TPPRSDTIANYELVYKDGEHG-EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 378 NST-LTAATAPNEVT----DLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRR 432
++ ++A T ++ + D+ + + S+++ W+ P P + +++ K
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPP--PVEKQNGIITEYSIKYTAVD 653
Query: 433 GQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCA--------- 483
G+D + + + ++ T Y +E LE T Y TV A DV +SL
Sbjct: 654 GEDDKPHEILGIP-SDTTKYLLEQLEKWTEYRITVTA-HTDVGPGPESLSVLIRTNEDVP 711
Query: 484 STYPDTVTITSCVSTSAGYGVNLIWSCP 511
S P V + + STS V + W P
Sbjct: 712 SGPPRKVEVEAVNSTS----VKVSWRSP 735
Score = 65.9 bits (159), Expect = 2e-10
Identities = 133/600 (22%), Positives = 224/600 (37%), Gaps = 70/600 (11%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTT--ATNVTVD 87
P N E ++ +SI LSW P D+ + V G+ G E R T T+ +
Sbjct: 516 PGQPLNFKAEPESETSILLSWTPPRS-DTIANYELVYKDGEHGE-EQRITIEPGTSYRLQ 573
Query: 88 GLGPGSLYTCSVWVEK-DGVNSSVGTVTTATAPN----PVRNLTVEAQTNSSIALTWEVP 142
GL P SLY + G+ +S ++ T + P ++++ + +++SI ++W+ P
Sbjct: 574 GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 633
Query: 143 DGPDPQN---STYGVEYTGDGGR-------AGTRSTAHTNITVDRLEPGCLYVFSVW--- 189
+ QN + Y ++YT G G S T +++LE Y +V
Sbjct: 634 P-VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDT-TKYLLEQLEKWTEYRITVTAHT 691
Query: 190 -VGKNGINSSRETRNATTAPN-PVRNLHMETQTNSSIALCWE--VPDGPYPQDYTYWVEY 245
VG + S R P+ P R + +E ++S+ + W VP+ + Q Y V Y
Sbjct: 692 DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHY 751
Query: 246 TGDGGGT-----------------ETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSR 288
G E +TT + L+P T Y+ +V A G+R
Sbjct: 752 VRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGAR 811
Query: 289 QNVSISTVPNAVTS---LSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQ 345
+ + AV L +T ++W P Y + + R+ M T
Sbjct: 812 SKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTL 871
Query: 346 STSGTD--ITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEV-----TDLQNETQ 398
S + T ++ G+ Y + A RN+V + + P EV +L +E
Sbjct: 872 EFSEKEDHFTATDIHKGASYVFRLSA-RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGT 930
Query: 399 TKNSVMLWWKAP--GDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEA 456
T SV L W+ P + + + Y + + P + Q +T +
Sbjct: 931 TSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME-------QLIVPADTTMTLTG 983
Query: 457 LEPGTLYNFTVWAERN-DVASSTQSLCASTYP-DTVTITSC-VSTSAGYGVNLIWSCPQG 513
L+P T Y+ V A + + S+ T P D V + V V L W P+
Sbjct: 984 LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPEN 1043
Query: 514 GYEAFELEVGGQRGSQDRSSCGEAVS--VLGLGPARSYPATITTIWDGMKVVSHSVVCHT 571
A ++ G G A ++ L P +SY +T + + H V T
Sbjct: 1044 YNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 1103
Score = 40.4 bits (93), Expect = 0.008
Identities = 43/188 (22%), Positives = 74/188 (39%), Gaps = 12/188 (6%)
Query: 123 RNLTVEAQTNSSIALTWEVPDGPDPQN--STYGVEYTGDG----GRAGTRSTAHTNITVD 176
+NL E T++S+ L+W+ P + + Y + Y A T +T+
Sbjct: 923 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT 982
Query: 177 RLEPGCLYVFSVWV----GKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPD 232
L+P Y V G + S + R +N H++ +S+ L WE+P+
Sbjct: 983 GLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1042
Query: 233 GPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVS 292
Y + + Y DG E + T L+P Y+F + N A G + V+
Sbjct: 1043 N-YNSAMPFKILY-DDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVT 1100
Query: 293 ISTVPNAV 300
T P+ +
Sbjct: 1101 AKTAPDVL 1108
Score = 35.0 bits (79), Expect = 0.33
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 3/117 (2%)
Query: 34 RNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGS 93
+N V+ +S+ LSWE+P+ +S + + DG E + AT + L P
Sbjct: 1022 KNFHVKAVMKTSVLLSWEIPENYNS--AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEK 1079
Query: 94 LYTCSVWVEKDGVNSSVGTVTTATAPNPVRNL-TVEAQTNSSIALTWEVPDGPDPQN 149
Y+ + + VT TAP+ +R +TN +T ++P+ P +N
Sbjct: 1080 SYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 1136
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 236 bits (602), Expect = 7e-62
Identities = 128/345 (37%), Positives = 189/345 (54%), Gaps = 26/345 (7%)
Query: 577 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP-----------------ELRDLVFSSP 619
+ G + ++ + +V ++ + ++R + +K ELR L F +P
Sbjct: 1257 VVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP 1316
Query: 620 G-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRN 674
G IP + ADH+ + + + N F+ +Y+ + G + ++ N KNRY N
Sbjct: 1317 GMASHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYAN 1375
Query: 675 VLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQS 734
V+ YD SRV L I PGSDY+NA+++ G +IATQG LP+T GDFWR++WEQ+S
Sbjct: 1376 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1435
Query: 735 HTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK 794
T+VM+T E RVKC+ YWP THG ++VTL+ + + VR L + +
Sbjct: 1436 ATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRTFALYKNGSSE 1494
Query: 795 TLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIA 854
VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG I
Sbjct: 1495 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTGCFIV 1552
Query: 855 LDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
+D +L +++ E + + V MR R MVQTE QY+F+H +L
Sbjct: 1553 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1597
Score = 199 bits (507), Expect = 8e-51
Identities = 107/287 (37%), Positives = 167/287 (58%), Gaps = 6/287 (2%)
Query: 621 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 675
++PA + +++K + ++ G ++++L S H+ + A+ N KNR N+
Sbjct: 1606 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1665
Query: 676 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 735
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL +T DFWR++WE S
Sbjct: 1666 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1725
Query: 736 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 795
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1726 IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1784
Query: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
+VRQF + WP+ GVP S + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1785 RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITL 1844
Query: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 902
++L +++ EG++ F V+ +R RP MVQTE QY F ++ L +L
Sbjct: 1845 SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1891
Score = 80.5 bits (197), Expect = 7e-15
Identities = 117/502 (23%), Positives = 190/502 (37%), Gaps = 50/502 (9%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGT---TETRNTTATNVTV 86
P P V T +SI+L+W+ G S Y +Q E T +V
Sbjct: 310 PKPPGTPVVTESTATSITLTWD--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSV 367
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPV-RNLTVEAQTNSSIALTWEV 141
GL P S Y V + + + V T T+ AP+ R++ ++++I + W+
Sbjct: 368 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 427
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDRLEPGCLYVFSVW----VGK 192
P+ P+ Q Y V YT D + H T+ L P Y V +G
Sbjct: 428 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 487
Query: 193 NGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGT 252
++S + T P N E ++ +SI L W P +Y + Y G
Sbjct: 488 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE--LVYKDGEHGE 545
Query: 253 ETRNT--TNTSVTAERLEPGTLYTFSVWAEK-NGARGSRQNVSISTVPNAVTS----LSK 305
E R T TS + L+P +LY F + A G S +S T+ + ++ +S
Sbjct: 546 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 605
Query: 306 QDWTNSTIALRWTAPQGPGQSSY--SYWVSWVREGMTDPRTQSTSG-----TDITLKELE 358
++++I + W P Q+ Y + + D + G T L++LE
Sbjct: 606 TSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLE 665
Query: 359 AGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTD-----LQNETQTKNSVMLWWKA--PG 411
+ Y +TV A + G S +V ++ E SV + W++ P
Sbjct: 666 KWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN 725
Query: 412 DPHSQLYVYWVQWA------SKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNF 465
H Q+ Y V + KG P A+ + T E + L+P T Y+
Sbjct: 726 KQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSL 785
Query: 466 TV--WAERNDVASSTQSLCAST 485
TV + + D A S L ++T
Sbjct: 786 TVTAYTTKGDGARSKPKLVSTT 807
Score = 68.6 bits (166), Expect = 3e-11
Identities = 104/448 (23%), Positives = 182/448 (40%), Gaps = 43/448 (9%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + GV ++ +T P P V T +SI LTW+ P+P S Y +
Sbjct: 287 YTC-VAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPV-SYYII 343
Query: 155 EYTGDGGRAGTR---STAHTNITVDRLEPGCLYVFSVW----VGKNGINSSRETRNATTA 207
++ + A T +V L P Y F V +G+ + T+ + A
Sbjct: 344 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA 403
Query: 208 PNPV-RNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNTTNTSV 262
P+ R++ ++++I + W+ P+ P Q Y V YT D N ++ +
Sbjct: 404 PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQI 463
Query: 263 TA-ERLEPGTLYTFSVWAEKNGARG----SRQNVSISTVPNAVTSLSKQDWTNSTIALRW 317
T L P Y+ V A + G Q ++ + VP + + + ++I L W
Sbjct: 464 TTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSW 523
Query: 318 TAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGY 377
T P+ ++Y G + R GT L+ L+ SLY+ + A + G
Sbjct: 524 TPPRSDTIANYELVYKDGEHG-EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 582
Query: 378 NST-LTAATAPNEVT----DLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRR 432
++ ++A T ++ + D+ + + S+++ W+ P P + +++ K
Sbjct: 583 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPP--PVEKQNGIITEYSIKYTAVD 640
Query: 433 GQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCA--------- 483
G+D + + + ++ T Y +E LE T Y TV A DV +SL
Sbjct: 641 GEDDKPHEILGIP-SDTTKYLLEQLEKWTEYRITVTA-HTDVGPGPESLSVLIRTNEDVP 698
Query: 484 STYPDTVTITSCVSTSAGYGVNLIWSCP 511
S P V + + STS V + W P
Sbjct: 699 SGPPRKVEVEAVNSTS----VKVSWRSP 722
Score = 65.9 bits (159), Expect = 2e-10
Identities = 133/600 (22%), Positives = 224/600 (37%), Gaps = 70/600 (11%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTT--ATNVTVD 87
P N E ++ +SI LSW P D+ + V G+ G E R T T+ +
Sbjct: 503 PGQPLNFKAEPESETSILLSWTPPRS-DTIANYELVYKDGEHGE-EQRITIEPGTSYRLQ 560
Query: 88 GLGPGSLYTCSVWVEK-DGVNSSVGTVTTATAPN----PVRNLTVEAQTNSSIALTWEVP 142
GL P SLY + G+ +S ++ T + P ++++ + +++SI ++W+ P
Sbjct: 561 GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 620
Query: 143 DGPDPQN---STYGVEYTGDGGR-------AGTRSTAHTNITVDRLEPGCLYVFSVW--- 189
+ QN + Y ++YT G G S T +++LE Y +V
Sbjct: 621 P-VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDT-TKYLLEQLEKWTEYRITVTAHT 678
Query: 190 -VGKNGINSSRETRNATTAPN-PVRNLHMETQTNSSIALCWE--VPDGPYPQDYTYWVEY 245
VG + S R P+ P R + +E ++S+ + W VP+ + Q Y V Y
Sbjct: 679 DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHY 738
Query: 246 TGDGGGT-----------------ETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSR 288
G E +TT + L+P T Y+ +V A G+R
Sbjct: 739 VRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGAR 798
Query: 289 QNVSISTVPNAVTS---LSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQ 345
+ + AV L +T ++W P Y + + R+ M T
Sbjct: 799 SKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTL 858
Query: 346 STSGTD--ITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEV-----TDLQNETQ 398
S + T ++ G+ Y + A RN+V + + P EV +L +E
Sbjct: 859 EFSEKEDHFTATDIHKGASYVFRLSA-RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGT 917
Query: 399 TKNSVMLWWKAP--GDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEA 456
T SV L W+ P + + + Y + + P + Q +T +
Sbjct: 918 TSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME-------QLIVPADTTMTLTG 970
Query: 457 LEPGTLYNFTVWAERN-DVASSTQSLCASTYP-DTVTITSC-VSTSAGYGVNLIWSCPQG 513
L+P T Y+ V A + + S+ T P D V + V V L W P+
Sbjct: 971 LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPEN 1030
Query: 514 GYEAFELEVGGQRGSQDRSSCGEAVS--VLGLGPARSYPATITTIWDGMKVVSHSVVCHT 571
A ++ G G A ++ L P +SY +T + + H V T
Sbjct: 1031 YNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 1090
Score = 40.4 bits (93), Expect = 0.008
Identities = 43/188 (22%), Positives = 74/188 (39%), Gaps = 12/188 (6%)
Query: 123 RNLTVEAQTNSSIALTWEVPDGPDPQN--STYGVEYTGDG----GRAGTRSTAHTNITVD 176
+NL E T++S+ L+W+ P + + Y + Y A T +T+
Sbjct: 910 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT 969
Query: 177 RLEPGCLYVFSVWV----GKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPD 232
L+P Y V G + S + R +N H++ +S+ L WE+P+
Sbjct: 970 GLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1029
Query: 233 GPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVS 292
Y + + Y DG E + T L+P Y+F + N A G + V+
Sbjct: 1030 N-YNSAMPFKILY-DDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVT 1087
Query: 293 ISTVPNAV 300
T P+ +
Sbjct: 1088 AKTAPDVL 1095
Score = 35.0 bits (79), Expect = 0.33
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 3/117 (2%)
Query: 34 RNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGS 93
+N V+ +S+ LSWE+P+ +S + + DG E + AT + L P
Sbjct: 1009 KNFHVKAVMKTSVLLSWEIPENYNS--AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEK 1066
Query: 94 LYTCSVWVEKDGVNSSVGTVTTATAPNPVRNL-TVEAQTNSSIALTWEVPDGPDPQN 149
Y+ + + VT TAP+ +R +TN +T ++P+ P +N
Sbjct: 1067 SYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 1123
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 236 bits (602), Expect = 7e-62
Identities = 128/345 (37%), Positives = 189/345 (54%), Gaps = 26/345 (7%)
Query: 577 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP-----------------ELRDLVFSSP 619
+ G + ++ + +V ++ + ++R + +K ELR L F +P
Sbjct: 1261 VVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP 1320
Query: 620 G-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRN 674
G IP + ADH+ + + + N F+ +Y+ + G + ++ N KNRY N
Sbjct: 1321 GMASHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYAN 1379
Query: 675 VLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQS 734
V+ YD SRV L I PGSDY+NA+++ G +IATQG LP+T GDFWR++WEQ+S
Sbjct: 1380 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1439
Query: 735 HTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK 794
T+VM+T E RVKC+ YWP THG ++VTL+ + + VR L + +
Sbjct: 1440 ATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRTFALYKNGSSE 1498
Query: 795 TLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIA 854
VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG I
Sbjct: 1499 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTGCFIV 1556
Query: 855 LDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
+D +L +++ E + + V MR R MVQTE QY+F+H +L
Sbjct: 1557 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1601
Score = 199 bits (507), Expect = 8e-51
Identities = 107/287 (37%), Positives = 167/287 (58%), Gaps = 6/287 (2%)
Query: 621 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 675
++PA + +++K + ++ G ++++L S H+ + A+ N KNR N+
Sbjct: 1610 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1669
Query: 676 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 735
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL +T DFWR++WE S
Sbjct: 1670 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1729
Query: 736 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 795
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1730 IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1788
Query: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
+VRQF + WP+ GVP S + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1789 RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITL 1848
Query: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 902
++L +++ EG++ F V+ +R RP MVQTE QY F ++ L +L
Sbjct: 1849 SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1895
Score = 77.0 bits (188), Expect = 8e-14
Identities = 112/496 (22%), Positives = 186/496 (37%), Gaps = 47/496 (9%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGT---TETRNTTATNVTV 86
P P V T +SI+L+W+ G S Y +Q E T +V
Sbjct: 323 PKPPGTPVVTESTATSITLTWD--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSV 380
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPV-RNLTVEAQTNSSIALTWEV 141
GL P S Y V + + + V T T+ AP+ R++ ++++I + W+
Sbjct: 381 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDRLEPGCLYVFSVW----VGK 192
P+ P+ Q Y V YT D + H T+ L P Y V +G
Sbjct: 441 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 500
Query: 193 NGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGT 252
++S + T P N E ++ +SI L W P +Y + Y G
Sbjct: 501 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE--LVYKDGEHGE 558
Query: 253 ETRNT--TNTSVTAERLEPGTLYTFSVWAEK-NGARGSRQNVSISTVPNAVTS----LSK 305
E R T TS + L+P +LY F + A G S +S T+ + ++ +S
Sbjct: 559 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 618
Query: 306 QDWTNSTIALRWTAPQGPGQSSY--SYWVSWVREGMTDPRTQSTSG-----TDITLKELE 358
++++I + W P Q+ Y + + D + G T L++LE
Sbjct: 619 TSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLE 678
Query: 359 AGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTD-----LQNETQTKNSVMLWWKA--PG 411
+ Y +TV A + G S +V ++ E SV + W++ P
Sbjct: 679 KWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN 738
Query: 412 DPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTV--WA 469
H Q+ Y V + G+ + + + L+P T Y+ TV +
Sbjct: 739 KQHGQIRGYQVHYV---RMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYT 795
Query: 470 ERNDVASSTQSLCAST 485
+ D A S L ++T
Sbjct: 796 TKGDGARSKPKLVSTT 811
Score = 70.9 bits (172), Expect = 5e-12
Identities = 116/505 (22%), Positives = 201/505 (39%), Gaps = 57/505 (11%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + GV ++ +T P P V T +SI LTW+ P+P S Y +
Sbjct: 300 YTC-VAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPV-SYYII 356
Query: 155 EYTGDGGRAGTR---STAHTNITVDRLEPGCLYVFSVW----VGKNGINSSRETRNATTA 207
++ + A T +V L P Y F V +G+ + T+ + A
Sbjct: 357 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA 416
Query: 208 PNPV-RNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNTTNTSV 262
P+ R++ ++++I + W+ P+ P Q Y V YT D N ++ +
Sbjct: 417 PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQI 476
Query: 263 TA-ERLEPGTLYTFSVWAEKNGARG----SRQNVSISTVPNAVTSLSKQDWTNSTIALRW 317
T L P Y+ V A + G Q ++ + VP + + + ++I L W
Sbjct: 477 TTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSW 536
Query: 318 TAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGY 377
T P+ ++Y G + R GT L+ L+ SLY+ + A + G
Sbjct: 537 TPPRSDTIANYELVYKDGEHG-EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 378 NST-LTAATAPNEVT----DLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRR 432
++ ++A T ++ + D+ + + S+++ W+ P P + +++ K
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPP--PVEKQNGIITEYSIKYTAVD 653
Query: 433 GQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCA--------- 483
G+D + + + ++ T Y +E LE T Y TV A DV +SL
Sbjct: 654 GEDDKPHEILGIP-SDTTKYLLEQLEKWTEYRITVTA-HTDVGPGPESLSVLIRTNEDVP 711
Query: 484 STYPDTVTITSCVSTSAGYGVNLIWSCPQ--------GGYEA--FELEVGGQRGSQDRSS 533
S P V + + STS V + W P GY+ +E G +G
Sbjct: 712 SGPPRKVEVEAVNSTS----VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD 767
Query: 534 C----GEAVSVLGLGPARSYPATIT 554
+ + + GL P SY T+T
Sbjct: 768 VMLADAQDMIISGLQPETSYSLTVT 792
Score = 45.4 bits (106), Expect = 2e-04
Identities = 52/222 (23%), Positives = 85/222 (38%), Gaps = 24/222 (10%)
Query: 32 PGRNLTVETQTTSSISLSWE--VPDGLDSQNSNYWVQCT--------GDGGTTETRNTTA 81
P R + VE ++S+ +SW VP+ Q Y V G + A
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 82 TNVTVDGLGPGSLYTCSVWV---EKDGVNSSVGTV-TTATAPNPVRNLTVEAQTNSSIAL 137
++ + GL P + Y+ +V + DG S V TT P R + Q N+++ +
Sbjct: 774 QDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL-I 832
Query: 138 TWEVPDGPDPQNSTYGVEYTGDGGRAGTR---STAHTNITVDRLEPGCLYVFSVWVGKNG 194
W P Y +++ T S + T + G YVF + +N
Sbjct: 833 QWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRL-SARNK 891
Query: 195 INSSRETRNATTAPNPV-----RNLHMETQTNSSIALCWEVP 231
+ E + P V +NLH E T++S+ L W+ P
Sbjct: 892 VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPP 933
Score = 40.4 bits (93), Expect = 0.008
Identities = 43/188 (22%), Positives = 74/188 (39%), Gaps = 12/188 (6%)
Query: 123 RNLTVEAQTNSSIALTWEVPDGPDPQN--STYGVEYTGDG----GRAGTRSTAHTNITVD 176
+NL E T++S+ L+W+ P + + Y + Y A T +T+
Sbjct: 914 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT 973
Query: 177 RLEPGCLYVFSVWV----GKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPD 232
L+P Y V G + S + R +N H++ +S+ L WE+P+
Sbjct: 974 GLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1033
Query: 233 GPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVS 292
Y + + Y DG E + T L+P Y+F + N A G + V+
Sbjct: 1034 N-YNSAMPFKILY-DDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVT 1091
Query: 293 ISTVPNAV 300
T P+ +
Sbjct: 1092 AKTAPDVL 1099
Score = 35.0 bits (79), Expect = 0.33
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 3/117 (2%)
Query: 34 RNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGS 93
+N V+ +S+ LSWE+P+ +S + + DG E + AT + L P
Sbjct: 1013 KNFHVKAVMKTSVLLSWEIPENYNS--AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEK 1070
Query: 94 LYTCSVWVEKDGVNSSVGTVTTATAPNPVRNL-TVEAQTNSSIALTWEVPDGPDPQN 149
Y+ + + VT TAP+ +R +TN +T ++P+ P +N
Sbjct: 1071 SYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 1127
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 236 bits (602), Expect = 7e-62
Identities = 128/345 (37%), Positives = 189/345 (54%), Gaps = 26/345 (7%)
Query: 577 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP-----------------ELRDLVFSSP 619
+ G + ++ + +V ++ + ++R + +K ELR L F +P
Sbjct: 859 VVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP 918
Query: 620 G-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRN 674
G IP + ADH+ + + + N F+ +Y+ + G + ++ N KNRY N
Sbjct: 919 GMASHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYAN 977
Query: 675 VLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQS 734
V+ YD SRV L I PGSDY+NA+++ G +IATQG LP+T GDFWR++WEQ+S
Sbjct: 978 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1037
Query: 735 HTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK 794
T+VM+T E RVKC+ YWP THG ++VTL+ + + VR L + +
Sbjct: 1038 ATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRTFALYKNGSSE 1096
Query: 795 TLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIA 854
VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG I
Sbjct: 1097 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTGCFIV 1154
Query: 855 LDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
+D +L +++ E + + V MR R MVQTE QY+F+H +L
Sbjct: 1155 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1199
Score = 199 bits (507), Expect = 8e-51
Identities = 107/287 (37%), Positives = 167/287 (58%), Gaps = 6/287 (2%)
Query: 621 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 675
++PA + +++K + ++ G ++++L S H+ + A+ N KNR N+
Sbjct: 1208 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1267
Query: 676 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 735
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL +T DFWR++WE S
Sbjct: 1268 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1327
Query: 736 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 795
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1328 IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1386
Query: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
+VRQF + WP+ GVP S + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1387 RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITL 1446
Query: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 902
++L +++ EG++ F V+ +R RP MVQTE QY F ++ L +L
Sbjct: 1447 SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1493
Score = 68.2 bits (165), Expect = 3e-11
Identities = 72/292 (24%), Positives = 120/292 (41%), Gaps = 20/292 (6%)
Query: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTAT 82
T +AP+ P R++ ++++I + W+ P+ + Q Y V T D T N
Sbjct: 412 TSEQAPSSAP-RDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDP-TQHVNNWMKH 469
Query: 83 NV------TVDGLGPGSLYTCSVWVEK---DG-VNSSVGTVTTATAPNPVRNLTVEAQTN 132
NV T+ L P Y+ V DG ++S + +T P N E ++
Sbjct: 470 NVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESE 529
Query: 133 SSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH--TNITVDRLEPGCLYVFSVWV 190
+SI L+W P N Y + Y R T T+ + L+P LY F +
Sbjct: 530 TSILLSWTPPRSDTIAN--YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587
Query: 191 -GKNGINSSRETRNATTAPNP-VRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGD 248
G+ +S +A T + +N H++ +S+ L WE+P+ Y + + Y D
Sbjct: 588 RSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN-YNSAMPFKILYD-D 645
Query: 249 GGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAV 300
G E + T L+P Y+F + N A G + V+ T P+ +
Sbjct: 646 GKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVL 697
Score = 62.8 bits (151), Expect = 1e-09
Identities = 79/342 (23%), Positives = 139/342 (40%), Gaps = 23/342 (6%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + GV ++ +T P P V T +SI LTW+ P+P S Y +
Sbjct: 300 YTC-VAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPV-SYYII 356
Query: 155 EYTGDGGRAGTR---STAHTNITVDRLEPGCLYVFSVW----VGKNGINSSRETRNATTA 207
++ + A T +V L P Y F V +G+ + T+ + A
Sbjct: 357 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA 416
Query: 208 PNPV-RNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNTTNTSV 262
P+ R++ ++++I + W+ P+ P Q Y V YT D N ++ +
Sbjct: 417 PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQI 476
Query: 263 TA-ERLEPGTLYTFSVWAEKNGARG----SRQNVSISTVPNAVTSLSKQDWTNSTIALRW 317
T L P Y+ V A + G Q ++ + VP + + + ++I L W
Sbjct: 477 TTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSW 536
Query: 318 TAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGY 377
T P+ ++Y G + R GT L+ L+ SLY+ + A + G
Sbjct: 537 TPPRSDTIANYELVYKDGEHG-EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 378 NSTLTAATAPNEV--TDLQNETQTKNSVMLWWKAPGDPHSQL 417
++ +A + + + K SV+L W+ P + +S +
Sbjct: 596 STAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAM 637
Score = 62.0 bits (149), Expect = 3e-09
Identities = 87/380 (22%), Positives = 142/380 (37%), Gaps = 28/380 (7%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGT---TETRNTTATNVTV 86
P P V T +SI+L+W+ G S Y +Q E T +V
Sbjct: 323 PKPPGTPVVTESTATSITLTWD--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSV 380
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPV-RNLTVEAQTNSSIALTWEV 141
GL P S Y V + + + V T T+ AP+ R++ ++++I + W+
Sbjct: 381 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDRLEPGCLYVFSVW----VGK 192
P+ P+ Q Y V YT D + H T+ L P Y V +G
Sbjct: 441 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 500
Query: 193 NGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGT 252
++S + T P N E ++ +SI L W P +Y + Y G
Sbjct: 501 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE--LVYKDGEHGE 558
Query: 253 ETRNT--TNTSVTAERLEPGTLYTFSVWAEK-NGARGSRQNVSISTVPNA-VTSLSKQDW 308
E R T TS + L+P +LY F + A G S +S T+ + + +
Sbjct: 559 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAV 618
Query: 309 TNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 368
+++ L W P+ S+ + + + M + T + L+ Y +
Sbjct: 619 MKTSVLLSWEIPEN-YNSAMPFKILYDDGKMVE--EVDGRATQKLIVNLKPEKSYSFVLT 675
Query: 369 AERNEVRGYNSTLTAATAPN 388
N G +TA TAP+
Sbjct: 676 NRGNSAGGLQHRVTAKTAPD 695
Score = 55.1 bits (131), Expect = 3e-07
Identities = 79/390 (20%), Positives = 136/390 (34%), Gaps = 46/390 (11%)
Query: 208 PNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGT---ETRNTTNTSVTA 264
P P + T +SI L W+ P P Y Y +++ E T +
Sbjct: 323 PKPPGTPVVTESTATSITLTWD-SGNPEPVSY-YIIQHKPKNSEELYKEIDGVATTRYSV 380
Query: 265 ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQD-----WTNSTIALRWTA 319
L P + Y F V A N RG ++ S + +D +++TI ++W
Sbjct: 381 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440
Query: 320 PQGPGQSSYSYWV-----------SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 368
P+ P Y V +W++ + D + T+ L Y + V
Sbjct: 441 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT-------TIGNLVPQKTYSVKVL 493
Query: 369 AERNEVRGYNST----LTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 424
A + G S+ +T P + + + E +++ S++L W P Y +
Sbjct: 494 AFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
Query: 425 ASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAER-NDVASSTQSLCA 483
G +R + T Y+++ L+P +LY F + A + +ST + A
Sbjct: 554 GEHGEEQR-----------ITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISA 602
Query: 484 STYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVS--VL 541
T V V L W P+ A ++ G G A ++
Sbjct: 603 RTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 662
Query: 542 GLGPARSYPATITTIWDGMKVVSHSVVCHT 571
L P +SY +T + + H V T
Sbjct: 663 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 692
Score = 35.0 bits (79), Expect = 0.33
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 3/117 (2%)
Query: 34 RNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGS 93
+N V+ +S+ LSWE+P+ +S + + DG E + AT + L P
Sbjct: 611 KNFHVKAVMKTSVLLSWEIPENYNS--AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEK 668
Query: 94 LYTCSVWVEKDGVNSSVGTVTTATAPNPVRNL-TVEAQTNSSIALTWEVPDGPDPQN 149
Y+ + + VT TAP+ +R +TN +T ++P+ P +N
Sbjct: 669 SYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 725
Score = 30.8 bits (68), Expect = 6.2
Identities = 31/142 (21%), Positives = 60/142 (42%), Gaps = 11/142 (7%)
Query: 291 VSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSG- 349
+++ +P + + T ++I L W + SY++ + ++ + G
Sbjct: 317 ITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYIIQHKPKNSEELYKEIDGV 373
Query: 350 --TDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAATAPNEVT-DLQNETQTKNS 402
T ++ L S Y V A N RG S T T+ AP+ D+Q + +
Sbjct: 374 ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT 433
Query: 403 VMLWWKAPGDPHSQLYVYWVQW 424
+++ WK P +P+ Q+ Y V +
Sbjct: 434 ILVQWKEPEEPNGQIQGYRVYY 455
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 235 bits (599), Expect = 2e-61
Identities = 124/295 (42%), Positives = 172/295 (58%), Gaps = 9/295 (3%)
Query: 610 ELRDLVFSSPG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASAS 664
ELR L F +PG IP + ADH+ + + + N F+ +Y+ + G + ++
Sbjct: 910 ELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLE 968
Query: 665 ENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGD 724
N KNRY NV+ YD SRV L I PGSDY+NA+++ G +IATQG LP+T GD
Sbjct: 969 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGD 1028
Query: 725 FWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRE 784
FWR++WEQ+S T+VM+T E RVKC+ YWP THG ++VTL+ + + VR
Sbjct: 1029 FWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRT 1087
Query: 785 LLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSA 844
L + + VRQF + AWPDHGVP P LAF R ++ + GP +VHCSA
Sbjct: 1088 FALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSA 1145
Query: 845 GVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
GVGRTG I +D +L +++ E + + V MR R MVQTE QY+F+H +L
Sbjct: 1146 GVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1200
Score = 199 bits (507), Expect = 8e-51
Identities = 107/287 (37%), Positives = 167/287 (58%), Gaps = 6/287 (2%)
Query: 621 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 675
++PA + +++K + ++ G ++++L S H+ + A+ N KNR N+
Sbjct: 1209 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1268
Query: 676 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 735
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL +T DFWR++WE S
Sbjct: 1269 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1328
Query: 736 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 795
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1329 IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1387
Query: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
+VRQF + WP+ GVP S + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1388 RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITL 1447
Query: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 902
++L +++ EG++ F V+ +R RP MVQTE QY F ++ L +L
Sbjct: 1448 SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1494
Score = 68.2 bits (165), Expect = 3e-11
Identities = 72/292 (24%), Positives = 120/292 (41%), Gaps = 20/292 (6%)
Query: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTAT 82
T +AP+ P R++ ++++I + W+ P+ + Q Y V T D T N
Sbjct: 409 TSEQAPSSAP-RDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDP-TQHVNNWMKH 466
Query: 83 NV------TVDGLGPGSLYTCSVWVEK---DG-VNSSVGTVTTATAPNPVRNLTVEAQTN 132
NV T+ L P Y+ V DG ++S + +T P N E ++
Sbjct: 467 NVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESE 526
Query: 133 SSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH--TNITVDRLEPGCLYVFSVWV 190
+SI L+W P N Y + Y R T T+ + L+P LY F +
Sbjct: 527 TSILLSWTPPRSDTIAN--YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 584
Query: 191 -GKNGINSSRETRNATTAPNP-VRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGD 248
G+ +S +A T + +N H++ +S+ L WE+P+ Y + + Y D
Sbjct: 585 RSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN-YNSAMPFKILYD-D 642
Query: 249 GGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAV 300
G E + T L+P Y+F + N A G + V+ T P+ +
Sbjct: 643 GKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVL 694
Score = 62.8 bits (151), Expect = 1e-09
Identities = 79/342 (23%), Positives = 139/342 (40%), Gaps = 23/342 (6%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + GV ++ +T P P V T +SI LTW+ P+P S Y +
Sbjct: 297 YTC-VAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPV-SYYII 353
Query: 155 EYTGDGGRAGTR---STAHTNITVDRLEPGCLYVFSVW----VGKNGINSSRETRNATTA 207
++ + A T +V L P Y F V +G+ + T+ + A
Sbjct: 354 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA 413
Query: 208 PNPV-RNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNTTNTSV 262
P+ R++ ++++I + W+ P+ P Q Y V YT D N ++ +
Sbjct: 414 PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQI 473
Query: 263 TA-ERLEPGTLYTFSVWAEKNGARG----SRQNVSISTVPNAVTSLSKQDWTNSTIALRW 317
T L P Y+ V A + G Q ++ + VP + + + ++I L W
Sbjct: 474 TTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSW 533
Query: 318 TAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGY 377
T P+ ++Y G + R GT L+ L+ SLY+ + A + G
Sbjct: 534 TPPRSDTIANYELVYKDGEHG-EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 592
Query: 378 NSTLTAATAPNEV--TDLQNETQTKNSVMLWWKAPGDPHSQL 417
++ +A + + + K SV+L W+ P + +S +
Sbjct: 593 STAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAM 634
Score = 62.0 bits (149), Expect = 3e-09
Identities = 87/380 (22%), Positives = 142/380 (37%), Gaps = 28/380 (7%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGT---TETRNTTATNVTV 86
P P V T +SI+L+W+ G S Y +Q E T +V
Sbjct: 320 PKPPGTPVVTESTATSITLTWD--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSV 377
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPV-RNLTVEAQTNSSIALTWEV 141
GL P S Y V + + + V T T+ AP+ R++ ++++I + W+
Sbjct: 378 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 437
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDRLEPGCLYVFSVW----VGK 192
P+ P+ Q Y V YT D + H T+ L P Y V +G
Sbjct: 438 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 497
Query: 193 NGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGT 252
++S + T P N E ++ +SI L W P +Y + Y G
Sbjct: 498 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE--LVYKDGEHGE 555
Query: 253 ETRNT--TNTSVTAERLEPGTLYTFSVWAEK-NGARGSRQNVSISTVPNA-VTSLSKQDW 308
E R T TS + L+P +LY F + A G S +S T+ + + +
Sbjct: 556 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAV 615
Query: 309 TNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 368
+++ L W P+ S+ + + + M + T + L+ Y +
Sbjct: 616 MKTSVLLSWEIPEN-YNSAMPFKILYDDGKMVE--EVDGRATQKLIVNLKPEKSYSFVLT 672
Query: 369 AERNEVRGYNSTLTAATAPN 388
N G +TA TAP+
Sbjct: 673 NRGNSAGGLQHRVTAKTAPD 692
Score = 55.1 bits (131), Expect = 3e-07
Identities = 79/390 (20%), Positives = 136/390 (34%), Gaps = 46/390 (11%)
Query: 208 PNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGT---ETRNTTNTSVTA 264
P P + T +SI L W+ P P Y Y +++ E T +
Sbjct: 320 PKPPGTPVVTESTATSITLTWD-SGNPEPVSY-YIIQHKPKNSEELYKEIDGVATTRYSV 377
Query: 265 ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQD-----WTNSTIALRWTA 319
L P + Y F V A N RG ++ S + +D +++TI ++W
Sbjct: 378 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 437
Query: 320 PQGPGQSSYSYWV-----------SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 368
P+ P Y V +W++ + D + T+ L Y + V
Sbjct: 438 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT-------TIGNLVPQKTYSVKVL 490
Query: 369 AERNEVRGYNST----LTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 424
A + G S+ +T P + + + E +++ S++L W P Y +
Sbjct: 491 AFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKD 550
Query: 425 ASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAER-NDVASSTQSLCA 483
G +R + T Y+++ L+P +LY F + A + +ST + A
Sbjct: 551 GEHGEEQR-----------ITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISA 599
Query: 484 STYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVS--VL 541
T V V L W P+ A ++ G G A ++
Sbjct: 600 RTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 659
Query: 542 GLGPARSYPATITTIWDGMKVVSHSVVCHT 571
L P +SY +T + + H V T
Sbjct: 660 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 689
Score = 35.0 bits (79), Expect = 0.33
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 3/117 (2%)
Query: 34 RNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGS 93
+N V+ +S+ LSWE+P+ +S + + DG E + AT + L P
Sbjct: 608 KNFHVKAVMKTSVLLSWEIPENYNS--AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEK 665
Query: 94 LYTCSVWVEKDGVNSSVGTVTTATAPNPVRNL-TVEAQTNSSIALTWEVPDGPDPQN 149
Y+ + + VT TAP+ +R +TN +T ++P+ P +N
Sbjct: 666 SYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 722
Score = 30.8 bits (68), Expect = 6.2
Identities = 31/142 (21%), Positives = 60/142 (42%), Gaps = 11/142 (7%)
Query: 291 VSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSG- 349
+++ +P + + T ++I L W + SY++ + ++ + G
Sbjct: 314 ITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYIIQHKPKNSEELYKEIDGV 370
Query: 350 --TDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAATAPNEVT-DLQNETQTKNS 402
T ++ L S Y V A N RG S T T+ AP+ D+Q + +
Sbjct: 371 ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT 430
Query: 403 VMLWWKAPGDPHSQLYVYWVQW 424
+++ WK P +P+ Q+ Y V +
Sbjct: 431 ILVQWKEPEEPNGQIQGYRVYY 452
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 232 bits (592), Expect = 1e-60
Identities = 116/278 (41%), Positives = 171/278 (61%), Gaps = 5/278 (1%)
Query: 622 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 681
I D H+ + +R GF ++Y+ L G + S A EN KNRY N++ YD S
Sbjct: 869 IRVADLLQHITQMKRGQGYGFKEEYEALP-EGQTASWDTAKEDENRNKNRYGNIISYDHS 927
Query: 682 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 741
RV L + +P SDYINA+++ G P+ +IATQGP+ +TV DFWR++W++ S ++VM+T
Sbjct: 928 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 987
Query: 742 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 801
N +E GRVKC YWP D++ +G ++VTL+ E + + +R + + + +R F
Sbjct: 988 NLVEVGRVKCVRYWPDDTE--VYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1045
Query: 802 HYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQ 861
H+ +WPDHGVP LL F R ++ E GP +VHCSAG GRTG IA+D +L
Sbjct: 1046 HFTSWPDHGVPCYATGLLGFVRQVK--FLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1103
Query: 862 LQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
++EG++ F+ VR++R R +VQTE QYVF+H IL
Sbjct: 1104 AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL 1141
Score = 123 bits (308), Expect = 9e-28
Identities = 85/278 (30%), Positives = 139/278 (50%), Gaps = 11/278 (3%)
Query: 632 RKNERDSNCGFADKYQQLSLVG---HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPI 688
R + + ++ D++Q L++V + + N+ KNR +VLP D L +
Sbjct: 1165 RLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISV 1224
Query: 689 HEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGR 748
E S+YINA+ M P F+ TQ PLP TV DFWRLV++ ++VML N M+ +
Sbjct: 1225 DGE-SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVML-NEMDTAQ 1282
Query: 749 VKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT--LSVRQFHYQAW 806
C YWP + C +G ++V V ++ E+ R + + + V+ Y W
Sbjct: 1283 F-CMQYWPEKTSGC-YGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGW 1340
Query: 807 PDH-GVPSSPDTLLAFWRMLRQWLDQ-TMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQS 864
P + P S +LL R L +W +Q G +VHC G GR+GT A+ + +Q
Sbjct: 1341 PAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQ 1400
Query: 865 EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 902
+ ++ F V+ +R ++ MV+T QY F+++ L +L
Sbjct: 1401 QNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL 1438
Score = 35.8 bits (81), Expect = 0.19
Identities = 20/74 (27%), Positives = 36/74 (48%), Gaps = 8/74 (10%)
Query: 400 KNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRT----NETWYKVE 455
+ + + WK P + + + +Y + + + G DP A+ +Q + NET +
Sbjct: 499 EEKIYIQWKPPNETNGVITLYEINYKAVG----SLDPSADLSSQRGKVFKLRNETHHLFV 554
Query: 456 ALEPGTLYNFTVWA 469
L PGT Y+FT+ A
Sbjct: 555 GLYPGTTYSFTIKA 568
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 232 bits (592), Expect = 1e-60
Identities = 116/278 (41%), Positives = 171/278 (61%), Gaps = 5/278 (1%)
Query: 622 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 681
I D H+ + +R GF ++Y+ L G + S A EN KNRY N++ YD S
Sbjct: 888 IRVADLLQHITQMKRGQGYGFKEEYEALP-EGQTASWDTAKEDENRNKNRYGNIISYDHS 946
Query: 682 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 741
RV L + +P SDYINA+++ G P+ +IATQGP+ +TV DFWR++W++ S ++VM+T
Sbjct: 947 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 1006
Query: 742 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 801
N +E GRVKC YWP D++ +G ++VTL+ E + + +R + + + +R F
Sbjct: 1007 NLVEVGRVKCVRYWPDDTE--VYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1064
Query: 802 HYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQ 861
H+ +WPDHGVP LL F R ++ E GP +VHCSAG GRTG IA+D +L
Sbjct: 1065 HFTSWPDHGVPCYATGLLGFVRQVK--FLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1122
Query: 862 LQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
++EG++ F+ VR++R R +VQTE QYVF+H IL
Sbjct: 1123 AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL 1160
Score = 123 bits (308), Expect = 9e-28
Identities = 85/278 (30%), Positives = 139/278 (50%), Gaps = 11/278 (3%)
Query: 632 RKNERDSNCGFADKYQQLSLVG---HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPI 688
R + + ++ D++Q L++V + + N+ KNR +VLP D L +
Sbjct: 1184 RLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISV 1243
Query: 689 HEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGR 748
E S+YINA+ M P F+ TQ PLP TV DFWRLV++ ++VML N M+ +
Sbjct: 1244 DGE-SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVML-NEMDTAQ 1301
Query: 749 VKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT--LSVRQFHYQAW 806
C YWP + C +G ++V V ++ E+ R + + + V+ Y W
Sbjct: 1302 F-CMQYWPEKTSGC-YGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGW 1359
Query: 807 PDH-GVPSSPDTLLAFWRMLRQWLDQ-TMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQS 864
P + P S +LL R L +W +Q G +VHC G GR+GT A+ + +Q
Sbjct: 1360 PAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQ 1419
Query: 865 EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 902
+ ++ F V+ +R ++ MV+T QY F+++ L +L
Sbjct: 1420 QNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL 1457
Score = 35.8 bits (81), Expect = 0.19
Identities = 20/74 (27%), Positives = 36/74 (48%), Gaps = 8/74 (10%)
Query: 400 KNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRT----NETWYKVE 455
+ + + WK P + + + +Y + + + G DP A+ +Q + NET +
Sbjct: 499 EEKIYIQWKPPNETNGVITLYEINYKAVG----SLDPSADLSSQRGKVFKLRNETHHLFV 554
Query: 456 ALEPGTLYNFTVWA 469
L PGT Y+FT+ A
Sbjct: 555 GLYPGTTYSFTIKA 568
Score = 30.4 bits (67), Expect = 8.1
Identities = 29/138 (21%), Positives = 60/138 (43%), Gaps = 10/138 (7%)
Query: 475 ASSTQSL---CASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFEL--EVGGQRGSQ 529
ASS SL A P + +T + N W+ P +++ + + + +
Sbjct: 655 ASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGE 714
Query: 530 DRSSCGEAVSVLGLGPARSYPAT-ITTIWDGMKVVSHSVV---CHTESAGVIAGAFVGIL 585
+ +C + +G A+ P T + + G + + V ++ +AG G+L
Sbjct: 715 TKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLL 774
Query: 586 LF-LILVGLLIFFLKRRN 602
+F +IL+G+++ +RRN
Sbjct: 775 MFIIILLGVMLTIKRRRN 792
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 232 bits (591), Expect = 1e-60
Identities = 129/349 (36%), Positives = 191/349 (54%), Gaps = 29/349 (8%)
Query: 576 VIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP--------------------ELRDLV 615
VI + + I++ +L++ K +K+K +P E+R +
Sbjct: 859 VIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRIN 918
Query: 616 FSSPG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKN 670
F +PG IP D A+H + + + + + +Y+ + G + ++ N KN
Sbjct: 919 FQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID-PGQQFTWEHSNLEVNKPKN 977
Query: 671 RYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVW 730
RY NV+ YD SRV L+PI GSDYINA+++ G +IATQGPLP+T GDFWR+VW
Sbjct: 978 RYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVW 1037
Query: 731 EQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQV 790
EQ+S T+VM+T E R+KC+ YWP + T+G ++VTL+ + + VR L +
Sbjct: 1038 EQRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKN 1096
Query: 791 EEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTG 850
+ VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG
Sbjct: 1097 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTG 1154
Query: 851 TLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
I +D +L +++ E + + V MR R MVQTE QY F+H+ +L
Sbjct: 1155 CFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL 1203
Score = 199 bits (505), Expect = 1e-50
Identities = 101/249 (40%), Positives = 148/249 (59%), Gaps = 1/249 (0%)
Query: 654 HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIA 713
H+ + A+ N KNR N++PY+ +RV L+PI GSDYINASF+ G + +IA
Sbjct: 1250 HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIA 1309
Query: 714 TQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVG 773
TQGPL +T DFWR++WE S +VMLT E GR KC YWP + + + + V +
Sbjct: 1310 TQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMA 1368
Query: 774 EEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTM 833
E M + +RE + + ++ +VRQF + WP+ GVP S + + F + + +Q
Sbjct: 1369 EYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1428
Query: 834 EGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVF 893
+ GP VHCSAGVGRTG I L ++L +++ EG++ F V+ +R RP MVQTE +Y F
Sbjct: 1429 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1488
Query: 894 LHQCILRFL 902
+Q L +L
Sbjct: 1489 CYQAALEYL 1497
Score = 55.8 bits (133), Expect = 2e-07
Identities = 93/385 (24%), Positives = 141/385 (36%), Gaps = 45/385 (11%)
Query: 32 PGRNLTVETQTTSSISLSWEV--PDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGL 89
PG + E T +SI+++W+ PD + Y + + DG + T T ++ GL
Sbjct: 326 PGTPMVTEN-TATSITITWDSGNPDPVSYYVIEYKSK-SQDGPYQIKEDITTTRYSIGGL 383
Query: 90 GPGSLYTCSVWVEKDGVNS--------SVGTVTTATAP-NPVRNLTVEAQTNSSIALTWE 140
P S Y +WV VNS SV T T AP + RN+ + +++ + WE
Sbjct: 384 SPNSEY--EIWVS--AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 439
Query: 141 VPDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDRLEPGCLYVFSVW----VG 191
P P+ Y V YT + H TV L Y V VG
Sbjct: 440 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 499
Query: 192 KNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGG 251
++ + + P NL E ++ +SI L W P Y G
Sbjct: 500 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 559
Query: 252 TETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGS-----RQNVSISTVPNAVTSLSKQ 306
TS E L+P T Y F + A G+ RQ S P + +
Sbjct: 560 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPK---NFKVK 616
Query: 307 DWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMT---DPRTQSTSGTDITLKELEAGSLY 363
+++ L W P S Y + + G+T D RT T + L+ + Y
Sbjct: 617 MIMKTSVLLSWEFPDN-YNSPTPYKIQY--NGLTLDVDGRT-----TKKLITHLKPHTFY 668
Query: 364 HLTVWAERNEVRGYNSTLTAATAPN 388
+ + + + G T+TA TA N
Sbjct: 669 NFVLTNRGSSLGGLQQTVTAWTAFN 693
Score = 39.3 bits (90), Expect = 0.017
Identities = 46/184 (25%), Positives = 76/184 (41%), Gaps = 10/184 (5%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRN-TTATNVTVDG 88
P NL E ++ +SI+LSW P +S + GD G R T+ V+
Sbjct: 516 PGQPMNLRAEARSETSITLSWS-PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVED 574
Query: 89 LGPGSLYTCSVWVEKD---GVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGP 145
L P + Y + G + V T + +P +N V+ +S+ L+WE PD
Sbjct: 575 LKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP-KNFKVKMIMKTSVLLSWEFPDNY 633
Query: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNAT 205
+ + Y ++Y G R+T + L+P Y F + + + ++T A
Sbjct: 634 N-SPTPYKIQYNGLTLDVDGRTTKK---LITHLKPHTFYNFVLTNRGSSLGGLQQTVTAW 689
Query: 206 TAPN 209
TA N
Sbjct: 690 TAFN 693
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 232 bits (591), Expect = 1e-60
Identities = 129/349 (36%), Positives = 191/349 (54%), Gaps = 29/349 (8%)
Query: 576 VIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP--------------------ELRDLV 615
VI + + I++ +L++ K +K+K +P E+R +
Sbjct: 1264 VIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRIN 1323
Query: 616 FSSPG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKN 670
F +PG IP D A+H + + + + + +Y+ + G + ++ N KN
Sbjct: 1324 FQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID-PGQQFTWEHSNLEVNKPKN 1382
Query: 671 RYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVW 730
RY NV+ YD SRV L+PI GSDYINA+++ G +IATQGPLP+T GDFWR+VW
Sbjct: 1383 RYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVW 1442
Query: 731 EQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQV 790
EQ+S T+VM+T E R+KC+ YWP + T+G ++VTL+ + + VR L +
Sbjct: 1443 EQRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKN 1501
Query: 791 EEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTG 850
+ VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG
Sbjct: 1502 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTG 1559
Query: 851 TLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
I +D +L +++ E + + V MR R MVQTE QY F+H+ +L
Sbjct: 1560 CFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL 1608
Score = 199 bits (505), Expect = 1e-50
Identities = 101/249 (40%), Positives = 148/249 (59%), Gaps = 1/249 (0%)
Query: 654 HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIA 713
H+ + A+ N KNR N++PY+ +RV L+PI GSDYINASF+ G + +IA
Sbjct: 1655 HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIA 1714
Query: 714 TQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVG 773
TQGPL +T DFWR++WE S +VMLT E GR KC YWP + + + + V +
Sbjct: 1715 TQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMA 1773
Query: 774 EEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTM 833
E M + +RE + + ++ +VRQF + WP+ GVP S + + F + + +Q
Sbjct: 1774 EYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1833
Query: 834 EGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVF 893
+ GP VHCSAGVGRTG I L ++L +++ EG++ F V+ +R RP MVQTE +Y F
Sbjct: 1834 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1893
Query: 894 LHQCILRFL 902
+Q L +L
Sbjct: 1894 CYQAALEYL 1902
Score = 72.4 bits (176), Expect = 2e-12
Identities = 113/483 (23%), Positives = 176/483 (36%), Gaps = 60/483 (12%)
Query: 32 PGRNLTVETQTTSSISLSWEV--PDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGL 89
PG + E T +SI+++W+ PD + Y + + DG + T T ++ GL
Sbjct: 322 PGTPMVTEN-TATSITITWDSGNPDPVSYYVIEYKSK-SQDGPYQIKEDITTTRYSIGGL 379
Query: 90 GPGSLYTCSVWVEKDGVNS--------SVGTVTTATAP-NPVRNLTVEAQTNSSIALTWE 140
P S Y +WV VNS SV T T AP + RN+ + +++ + WE
Sbjct: 380 SPNSEY--EIWVS--AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
Query: 141 VPDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDRLEPGCLYVFSVW----VG 191
P P+ Y V YT + H TV L Y V VG
Sbjct: 436 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
Query: 192 KNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGG 251
++ + + P NL E ++ +SI L W P Y G
Sbjct: 496 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
Query: 252 TETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNV----SISTVPNAVTSLSKQD 307
TS E L+P T Y F + A G+ V ++ + P+A K
Sbjct: 556 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 615
Query: 308 WTNST---IALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSG-----TDITLKELEA 359
ST ++ R P+ + Y V + G DP + +G T I L+ LE
Sbjct: 616 SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 675
Query: 360 GSLYHLTVWAERNEVRGYNSTLTAATAPNEVTD-----LQNETQTKNSVMLWWK--APGD 412
+ Y +T A G S+ +V ++ E ++ + W+ APG
Sbjct: 676 WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 735
Query: 413 PHSQLYVYWVQWA------SKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFT 466
H Q+ Y V + ++G PR + + + L+P T Y+ T
Sbjct: 736 QHGQIRGYQVHYVRMEGAEARGPPR---------IKDVMLADAQEMVITNLQPETAYSIT 786
Query: 467 VWA 469
V A
Sbjct: 787 VAA 789
Score = 37.7 bits (86), Expect = 0.051
Identities = 67/289 (23%), Positives = 104/289 (35%), Gaps = 32/289 (11%)
Query: 36 LTVETQTTSSISLSWEVPDGL-DSQNSNYWVQCTGDGGT---TETRNTTATNVTVDGLGP 91
L+V+ S+ WE P G + Q Y +Q + T T + T G+
Sbjct: 816 LSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHK 875
Query: 92 GSLYTCSVWVE-KDGVNSSVGTVTTATAPNPVRNLTV-EAQTNSS---IALTWEVPDGPD 146
G+ Y + + G+ V + P + + EA N+S + L W +P P
Sbjct: 876 GATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRW-LPPVPA 934
Query: 147 PQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATT 206
+N V+YT AG A EPG ++ K + R T
Sbjct: 935 ERNGAI-VKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTR 993
Query: 207 -APNPV----------------RNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDG 249
P P +N ++ +S+ L WE PD Y Y ++Y G
Sbjct: 994 RGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDN-YNSPTPYKIQYNGLT 1052
Query: 250 GGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPN 298
+ R TT +T L+P T Y F + + G +Q V+ T N
Sbjct: 1053 LDVDGR-TTKKLIT--HLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFN 1098
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 232 bits (591), Expect = 1e-60
Identities = 129/349 (36%), Positives = 191/349 (54%), Gaps = 29/349 (8%)
Query: 576 VIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP--------------------ELRDLV 615
VI + + I++ +L++ K +K+K +P E+R +
Sbjct: 855 VIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRIN 914
Query: 616 FSSPG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKN 670
F +PG IP D A+H + + + + + +Y+ + G + ++ N KN
Sbjct: 915 FQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID-PGQQFTWEHSNLEVNKPKN 973
Query: 671 RYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVW 730
RY NV+ YD SRV L+PI GSDYINA+++ G +IATQGPLP+T GDFWR+VW
Sbjct: 974 RYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVW 1033
Query: 731 EQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQV 790
EQ+S T+VM+T E R+KC+ YWP + T+G ++VTL+ + + VR L +
Sbjct: 1034 EQRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKN 1092
Query: 791 EEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTG 850
+ VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG
Sbjct: 1093 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTG 1150
Query: 851 TLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
I +D +L +++ E + + V MR R MVQTE QY F+H+ +L
Sbjct: 1151 CFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL 1199
Score = 199 bits (505), Expect = 1e-50
Identities = 101/249 (40%), Positives = 148/249 (59%), Gaps = 1/249 (0%)
Query: 654 HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIA 713
H+ + A+ N KNR N++PY+ +RV L+PI GSDYINASF+ G + +IA
Sbjct: 1246 HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIA 1305
Query: 714 TQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVG 773
TQGPL +T DFWR++WE S +VMLT E GR KC YWP + + + + V +
Sbjct: 1306 TQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMA 1364
Query: 774 EEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTM 833
E M + +RE + + ++ +VRQF + WP+ GVP S + + F + + +Q
Sbjct: 1365 EYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1424
Query: 834 EGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVF 893
+ GP VHCSAGVGRTG I L ++L +++ EG++ F V+ +R RP MVQTE +Y F
Sbjct: 1425 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1484
Query: 894 LHQCILRFL 902
+Q L +L
Sbjct: 1485 CYQAALEYL 1493
Score = 55.8 bits (133), Expect = 2e-07
Identities = 93/385 (24%), Positives = 141/385 (36%), Gaps = 45/385 (11%)
Query: 32 PGRNLTVETQTTSSISLSWEV--PDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGL 89
PG + E T +SI+++W+ PD + Y + + DG + T T ++ GL
Sbjct: 322 PGTPMVTEN-TATSITITWDSGNPDPVSYYVIEYKSK-SQDGPYQIKEDITTTRYSIGGL 379
Query: 90 GPGSLYTCSVWVEKDGVNS--------SVGTVTTATAP-NPVRNLTVEAQTNSSIALTWE 140
P S Y +WV VNS SV T T AP + RN+ + +++ + WE
Sbjct: 380 SPNSEY--EIWVS--AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
Query: 141 VPDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDRLEPGCLYVFSVW----VG 191
P P+ Y V YT + H TV L Y V VG
Sbjct: 436 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
Query: 192 KNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGG 251
++ + + P NL E ++ +SI L W P Y G
Sbjct: 496 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
Query: 252 TETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGS-----RQNVSISTVPNAVTSLSKQ 306
TS E L+P T Y F + A G+ RQ S P + +
Sbjct: 556 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPK---NFKVK 612
Query: 307 DWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMT---DPRTQSTSGTDITLKELEAGSLY 363
+++ L W P S Y + + G+T D RT T + L+ + Y
Sbjct: 613 MIMKTSVLLSWEFPDN-YNSPTPYKIQY--NGLTLDVDGRT-----TKKLITHLKPHTFY 664
Query: 364 HLTVWAERNEVRGYNSTLTAATAPN 388
+ + + + G T+TA TA N
Sbjct: 665 NFVLTNRGSSLGGLQQTVTAWTAFN 689
Score = 39.3 bits (90), Expect = 0.017
Identities = 46/184 (25%), Positives = 76/184 (41%), Gaps = 10/184 (5%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRN-TTATNVTVDG 88
P NL E ++ +SI+LSW P +S + GD G R T+ V+
Sbjct: 512 PGQPMNLRAEARSETSITLSWS-PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVED 570
Query: 89 LGPGSLYTCSVWVEKD---GVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGP 145
L P + Y + G + V T + +P +N V+ +S+ L+WE PD
Sbjct: 571 LKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP-KNFKVKMIMKTSVLLSWEFPDNY 629
Query: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNAT 205
+ + Y ++Y G R+T + L+P Y F + + + ++T A
Sbjct: 630 N-SPTPYKIQYNGLTLDVDGRTTKK---LITHLKPHTFYNFVLTNRGSSLGGLQQTVTAW 685
Query: 206 TAPN 209
TA N
Sbjct: 686 TAFN 689
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 231 bits (588), Expect = 3e-60
Identities = 118/284 (41%), Positives = 170/284 (59%), Gaps = 11/284 (3%)
Query: 622 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 681
I D H+ + + GF ++Y+ G S S VA +N AKNRY N++ YD S
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESF-FEGQSASWDVAKKDQNRAKNRYGNIIAYDHS 926
Query: 682 RVPLKPIHEEPGSDYINASFMP------GLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 735
RV L+P+ ++P SDYINA+++ G P +IATQGP+ +TV DFWR++W++QS
Sbjct: 927 RVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSA 986
Query: 736 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 795
+VM+TN +E GRVKC YWP D++ +G +VT V E + + VR L + +
Sbjct: 987 CIVMVTNLVEVGRVKCYKYWPDDTE--VYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEI 1044
Query: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
V+QFH+ WPDHGVP LL+F R ++ L GP +VHCSAG GRTG I +
Sbjct: 1045 REVKQFHFTGWPDHGVPYHATGLLSFIRRVK--LSNPPSAGPIVVHCSAGAGRTGCYIVI 1102
Query: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
D++L + EG++ ++ V+ +R R MVQTE QY+F+H IL
Sbjct: 1103 DIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL 1146
Score = 125 bits (314), Expect = 2e-28
Identities = 87/287 (30%), Positives = 144/287 (50%), Gaps = 13/287 (4%)
Query: 627 FADHVRKNERDSNCGFADKYQQLSLVG---HSQSQMVASASENNAKNRYRNVLPYDWSRV 683
+ D +R + + ++ D++Q L+ V ++ +A N+ KNR+ ++LP D
Sbjct: 1165 YFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLP 1224
Query: 684 PLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNC 743
L I E S+YINA+ M P FI TQ PLP TV DFWRLV++ ++VML
Sbjct: 1225 FLITIDGE-SSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV 1283
Query: 744 -MEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVR--ELLLLQVEEQKTLSVRQ 800
+ G C YWP + +G ++V + + + R + L ++ L V+Q
Sbjct: 1284 DLSQG---CPQYWPEEGM-LRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQ 1339
Query: 801 FHYQAWPDH-GVPSSPDTLLAFWRMLRQWLDQTMEG-GPPIVHCSAGVGRTGTLIALDVL 858
F Y W H VP S + L + +W ++ EG G I+HC G GR+G A+ ++
Sbjct: 1340 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1399
Query: 859 LRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQS 905
+ ++ + ++ F V+ +R S+P MV+ QY F + L +L+ S
Sbjct: 1400 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS 1446
Score = 34.7 bits (78), Expect = 0.43
Identities = 31/124 (25%), Positives = 48/124 (38%), Gaps = 15/124 (12%)
Query: 387 PNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSR 446
P V LQ T +N + L WK P DP+ + Y + ++S R DP
Sbjct: 492 PVPVKSLQG-TSFENKIFLNWKEPLDPNGIITQYEISYSS----IRSFDPAVPVAGPPQT 546
Query: 447 TNETWYKVE----ALEPGTLYNFTVWAER------NDVASSTQSLCASTYPDTVTITSCV 496
+ W L PGT Y F + A + T ++ A T PD + + +
Sbjct: 547 VSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASL 606
Query: 497 STSA 500
+ +A
Sbjct: 607 NETA 610
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 224 bits (572), Expect = 2e-58
Identities = 233/925 (25%), Positives = 371/925 (40%), Gaps = 125/925 (13%)
Query: 67 CTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEK--DGVNSSVGTV--TTATAPNPV 122
CT G + + +T+ + L P + Y SV + + +G S G T +P+
Sbjct: 321 CTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPM 380
Query: 123 RN---LTVEAQTNSSIALTWEVPDGPDPQNSTYG--VEYTGD-GGRAGTRS-------TA 169
R L V + I + WE + +Y V Y GG+ R +
Sbjct: 381 RGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENS 440
Query: 170 HTNITVDRLEPGC-LYVFSVWVGKNGINSSRE--TRNATTAPNPVRNLHMETQT-NSSIA 225
H T+ L P + V + + G S+E + P V ++ T I
Sbjct: 441 HPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIF 500
Query: 226 LCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLE-----------PGTLYT 274
L W P Y Y + Y + +N S +L PGT Y+
Sbjct: 501 LQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYS 560
Query: 275 FSVWAEKNGARGSRQNVSISTVPNAV--------TSLSKQDWTNSTIALRWTAPQGPGQS 326
F++ A G +T +A T L++ D T T+ L+ +G S
Sbjct: 561 FTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNT-VTVMLKPAHSRGAPVS 619
Query: 327 SYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATA 386
Y V R T T+ + + A L +A + + A
Sbjct: 620 VYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAE-----FPADSLQAAQ 674
Query: 387 PNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYW--------------VQWASKGH--P 430
P + D +T N +W P P+ +Y+ VQ A+KG P
Sbjct: 675 PFTIGD----NKTYNG---YWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATP 727
Query: 431 RRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWA------ERNDVASSTQSLCAS 484
+ +P+ QT T K+ + G L ++ ++ +A + +S
Sbjct: 728 KPVPEPE----KQTDHT----VKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSS 779
Query: 485 TYPD-TVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGL 543
T + TV + S + A G N C + + + R SS + L
Sbjct: 780 TRQEMTVMVNSMDKSYAEQGTN----CDEA-FSFMDTHNLNGRSVSSPSSFTMKTNTLST 834
Query: 544 GPARSY---PATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKR 600
SY P T I + +H++ T S ++
Sbjct: 835 SVPNSYYPDPFVPTAILVPINDETHTMASDTSS-----------------------LVQS 871
Query: 601 RNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMV 660
KK++ ++ I D H+ + + GF ++Y+ G S
Sbjct: 872 HTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDS 930
Query: 661 ASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQ 720
A EN KNRY N++ YD SRV L+ I + SDYIN +++ G P +IATQGP+ +
Sbjct: 931 AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQE 990
Query: 721 TVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENW 780
T+ DFWR+VW + + +++M+TN +E GRVKC YWP D++ + ++VTL+ E++ +
Sbjct: 991 TIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTE--IYKDIKVTLIETELLAEY 1048
Query: 781 TVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIV 840
+R + + + +RQFH+ WPDHGVP LL F R ++ GP +V
Sbjct: 1049 VIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVV 1106
Query: 841 HCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR 900
HCSAG GRTG I +D++L + EG++ ++ VR++R R MVQTE QYVF+H IL
Sbjct: 1107 HCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL- 1165
Query: 901 FLQQSAQAPAEKEVPYEDVENLIYE 925
A + VP V +L Y+
Sbjct: 1166 ----EACLCGDTSVPASQVRSLYYD 1186
Score = 117 bits (294), Expect = 4e-26
Identities = 80/247 (32%), Positives = 122/247 (49%), Gaps = 8/247 (3%)
Query: 660 VASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLP 719
+A N+ KNR ++LP D L I E S+YINA+ M P FI TQ PLP
Sbjct: 1220 IALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLP 1278
Query: 720 QTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMEN 779
TV DFWRLV + ++VML + A C YWP ++ HG ++V V ++ E+
Sbjct: 1279 NTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP-ENGVHRHGPIQVEFVSADLEED 1335
Query: 780 WTVRELLLLQVEEQKT--LSVRQFHYQAWPDH-GVPSSPDTLLAFWRMLRQWLDQTMEG- 835
R + + V+QF + WP + P S + L R + +W ++ G
Sbjct: 1336 IISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1395
Query: 836 GPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLH 895
G +VHC G GR+GT A+ ++ L+ + + F V+ +R ++P MV QY F +
Sbjct: 1396 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1455
Query: 896 QCILRFL 902
+ L +L
Sbjct: 1456 EVALEYL 1462
Score = 38.5 bits (88), Expect = 0.030
Identities = 115/499 (23%), Positives = 176/499 (35%), Gaps = 86/499 (17%)
Query: 154 VEY-TGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWV---GKNGINSSRET-RNATTAP 208
VEY T G + T+ + L+P Y SV + G+ G S R T
Sbjct: 318 VEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCA 377
Query: 209 NPVRN---LHMETQTNSSIALCWEVPDG---PYPQDYTYWVEYTGDGGGTET-------- 254
+P+R L + + I + WE P G Y V Y GG E
Sbjct: 378 DPMRGPRKLEVVEVKSRQITIRWE-PFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436
Query: 255 RNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSIST---VPNAVTSLSKQDWT-N 310
++ T L P T + + R Q + + T +P AV + S Q T
Sbjct: 437 TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496
Query: 311 STIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQ--STSG--------TDITLKELEAG 360
I L+W P Y +++ DP + SG T L G
Sbjct: 497 EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556
Query: 361 SLYHLTVWAERNEVRG---YNSTLTAATAPNEVTDLQNET---QTKNSVMLWWKAPGDPH 414
+ Y T+ A + G N T +AP+ + + ET QT N+V + K
Sbjct: 557 TTYSFTIRASTAKGFGPPATNQFTTKISAPS-MPAYELETPLNQTDNTVTVMLKPAHSRG 615
Query: 415 SQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETW--YKVEA-LEPGTLYNFTVWAER 471
+ + VY + + PRR T +T E Y V + +L N +
Sbjct: 616 APVSVYQIV-VEEERPRR-----------TKKTTEILKCYPVPIHFQNASLLNSQYYFAA 663
Query: 472 NDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFEL--EVGGQRGSQ 529
A S Q+ T D T GY W+ P Y+++ + + + +
Sbjct: 664 EFPADSLQAAQPFTIGDNKTYN-------GY-----WNTPLLPYKSYRIYFQAASRANGE 711
Query: 530 DRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLI 589
+ C V V G A P + K H+V IAG GILLF+I
Sbjct: 712 TKIDC---VQVATKGAATPKPVP-----EPEKQTDHTVK--------IAGVIAGILLFVI 755
Query: 590 LVGLLIFFLKRRNKKKQQK 608
+ ++ +K+R K++K
Sbjct: 756 IFLGVVLVMKKRKLAKKRK 774
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 223 bits (569), Expect = 5e-58
Identities = 128/365 (35%), Positives = 190/365 (52%), Gaps = 45/365 (12%)
Query: 576 VIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP--------------------ELRDLV 615
VI + + I++ +L++ K +K+K +P E+R +
Sbjct: 1286 VIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRIN 1345
Query: 616 FSSPGD---------------------IPAEDFADHVRKNERDSNCGFADKYQQLSLVGH 654
F +P IP D A+H + + + + + +Y+ + G
Sbjct: 1346 FQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID-PGQ 1404
Query: 655 SQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIAT 714
+ ++ N KNRY NV+ YD SRV L+PI GSDYINA+++ G +IAT
Sbjct: 1405 QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIAT 1464
Query: 715 QGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGE 774
QGPLP+T GDFWR+VWEQ+S T+VM+T E R+KC+ YWP + T+G ++VTL+
Sbjct: 1465 QGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDT 1523
Query: 775 EVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTME 834
+ + VR L + + VRQF + AWPDHGVP P LAF R ++ +
Sbjct: 1524 IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPD 1581
Query: 835 GGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFL 894
GP +VHCSAGVGRTG I +D +L +++ E + + V MR R MVQTE QY F+
Sbjct: 1582 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1641
Query: 895 HQCIL 899
H+ +L
Sbjct: 1642 HEALL 1646
Score = 199 bits (505), Expect = 1e-50
Identities = 101/249 (40%), Positives = 148/249 (59%), Gaps = 1/249 (0%)
Query: 654 HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIA 713
H+ + A+ N KNR N++PY+ +RV L+PI GSDYINASF+ G + +IA
Sbjct: 1693 HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIA 1752
Query: 714 TQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVG 773
TQGPL +T DFWR++WE S +VMLT E GR KC YWP + + + + V +
Sbjct: 1753 TQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMA 1811
Query: 774 EEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTM 833
E M + +RE + + ++ +VRQF + WP+ GVP S + + F + + +Q
Sbjct: 1812 EYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1871
Query: 834 EGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVF 893
+ GP VHCSAGVGRTG I L ++L +++ EG++ F V+ +R RP MVQTE +Y F
Sbjct: 1872 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1931
Query: 894 LHQCILRFL 902
+Q L +L
Sbjct: 1932 CYQAALEYL 1940
Score = 78.6 bits (192), Expect = 3e-14
Identities = 117/483 (24%), Positives = 180/483 (37%), Gaps = 51/483 (10%)
Query: 32 PGRNLTVETQTTSSISLSWEV--PDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGL 89
PG + E T +SI+++W+ PD + Y + + DG + T T ++ GL
Sbjct: 335 PGTPMVTEN-TATSITITWDSGNPDPVSYYVIEYKSK-SQDGPYQIKEDITTTRYSIGGL 392
Query: 90 GPGSLYTCSVWVEKDGVNS--------SVGTVTTATAP-NPVRNLTVEAQTNSSIALTWE 140
P S Y +WV VNS SV T T AP + RN+ + +++ + WE
Sbjct: 393 SPNSEY--EIWVS--AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 448
Query: 141 VPDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDRLEPGCLYVFSVW----VG 191
P P+ Y V YT + H TV L Y V VG
Sbjct: 449 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 508
Query: 192 KNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGG 251
++ + + P NL E ++ +SI L W P Y G
Sbjct: 509 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 568
Query: 252 TETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNV----SISTVPNAVTSLSKQD 307
TS E L+P T Y F + A G+ V ++ + P+A K
Sbjct: 569 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628
Query: 308 WTNST---IALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSG-----TDITLKELEA 359
ST ++ R P+ + Y V + G DP + +G T I L+ LE
Sbjct: 629 SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688
Query: 360 GSLYHLTVWAERNEVRGYNSTLTAATAPNEVTD-----LQNETQTKNSVMLWWK--APGD 412
+ Y +T A G S+ +V ++ E ++ + W+ APG
Sbjct: 689 WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
Query: 413 PHSQLYVYWVQWA------SKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFT 466
H Q+ Y V + ++G PR A+ +T T E + L+P T Y+ T
Sbjct: 749 QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSIT 808
Query: 467 VWA 469
V A
Sbjct: 809 VAA 811
Score = 47.4 bits (111), Expect = 6e-05
Identities = 79/354 (22%), Positives = 125/354 (35%), Gaps = 45/354 (12%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRN-TTATNVTVDG 88
P NL E ++ +SI+LSW P +S + GD G R T+ V+
Sbjct: 525 PGQPMNLRAEARSETSITLSWS-PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVED 583
Query: 89 LGPGSLYTCSVWVEK-DGVNSSVGTVTTATAPN----PVRNLTVEAQTNSSIALTWEVPD 143
L P + Y + G+ + V T + P +++ + +++I ++W P
Sbjct: 584 LKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPP 643
Query: 144 GPDPQNST---YGVEYTGDGGRAGTRSTAH------TNITVDRLEPGCLY----VFSVWV 190
P+ N Y V Y G + T I ++ LE Y V V
Sbjct: 644 -PETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEV 702
Query: 191 GKNGINSSRETRNATTAPN-PVRNLHMETQTNSSIALCWE--VPDGPYPQDYTYWVEYTG 247
G +S R P+ P R + E ++I + W P + Q Y V Y
Sbjct: 703 GPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVR 762
Query: 248 DGGGT-----------------ETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQN 290
G ET +T + L+P T Y+ +V A G+R
Sbjct: 763 MEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSK 822
Query: 291 VSISTVPNAV---TSLSKQDWTNSTIALRWTAPQGPGQSS-YSYWVSWVREGMT 340
+ AV +LS Q ++ RW P G + Y + + RE T
Sbjct: 823 PKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDST 876
Score = 37.7 bits (86), Expect = 0.051
Identities = 67/289 (23%), Positives = 104/289 (35%), Gaps = 32/289 (11%)
Query: 36 LTVETQTTSSISLSWEVPDGL-DSQNSNYWVQCTGDGGT---TETRNTTATNVTVDGLGP 91
L+V+ S+ WE P G + Q Y +Q + T T + T G+
Sbjct: 838 LSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHK 897
Query: 92 GSLYTCSVWVE-KDGVNSSVGTVTTATAPNPVRNLTV-EAQTNSS---IALTWEVPDGPD 146
G+ Y + + G+ V + P + + EA N+S + L W +P P
Sbjct: 898 GATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRW-LPPVPA 956
Query: 147 PQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATT 206
+N V+YT AG A EPG ++ K + R T
Sbjct: 957 ERNGAI-VKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTR 1015
Query: 207 -APNPV----------------RNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDG 249
P P +N ++ +S+ L WE PD Y Y ++Y G
Sbjct: 1016 RGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDN-YNSPTPYKIQYNGLT 1074
Query: 250 GGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPN 298
+ R TT +T L+P T Y F + + G +Q V+ T N
Sbjct: 1075 LDVDGR-TTKKLIT--HLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFN 1120
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 223 bits (568), Expect = 6e-58
Identities = 115/304 (37%), Positives = 172/304 (56%), Gaps = 10/304 (3%)
Query: 622 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 681
I D H+ + + GF ++Y+ G S A EN KNRY N++ YD S
Sbjct: 880 IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 938
Query: 682 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 741
RV L+ I + SDYIN +++ G P +IATQGP+ +T+ DFWR+VW + + +++M+T
Sbjct: 939 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 998
Query: 742 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 801
N +E GRVKC YWP D++ + ++VTL+ E++ + +R + + + +RQF
Sbjct: 999 NLVEVGRVKCCKYWPDDTE--IYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQF 1056
Query: 802 HYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQ 861
H+ WPDHGVP LL F R ++ GP +VHCSAG GRTG I +D++L
Sbjct: 1057 HFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1114
Query: 862 LQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVEN 921
+ EG++ ++ VR++R R MVQTE QYVF+H IL A + VP V +
Sbjct: 1115 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL-----EACLCGDTSVPASQVRS 1169
Query: 922 LIYE 925
L Y+
Sbjct: 1170 LYYD 1173
Score = 117 bits (294), Expect = 4e-26
Identities = 80/247 (32%), Positives = 122/247 (49%), Gaps = 8/247 (3%)
Query: 660 VASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLP 719
+A N+ KNR ++LP D L I E S+YINA+ M P FI TQ PLP
Sbjct: 1207 IALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLP 1265
Query: 720 QTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMEN 779
TV DFWRLV + ++VML + A C YWP ++ HG ++V V ++ E+
Sbjct: 1266 NTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP-ENGVHRHGPIQVEFVSADLEED 1322
Query: 780 WTVRELLLLQVEEQKT--LSVRQFHYQAWPDH-GVPSSPDTLLAFWRMLRQWLDQTMEG- 835
R + + V+QF + WP + P S + L R + +W ++ G
Sbjct: 1323 IISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1382
Query: 836 GPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLH 895
G +VHC G GR+GT A+ ++ L+ + + F V+ +R ++P MV QY F +
Sbjct: 1383 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1442
Query: 896 QCILRFL 902
+ L +L
Sbjct: 1443 EVALEYL 1449
Score = 38.5 bits (88), Expect = 0.030
Identities = 115/499 (23%), Positives = 176/499 (35%), Gaps = 86/499 (17%)
Query: 154 VEY-TGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWV---GKNGINSSRET-RNATTAP 208
VEY T G + T+ + L+P Y SV + G+ G S R T
Sbjct: 318 VEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCA 377
Query: 209 NPVRN---LHMETQTNSSIALCWEVPDG---PYPQDYTYWVEYTGDGGGTET-------- 254
+P+R L + + I + WE P G Y V Y GG E
Sbjct: 378 DPMRGPRKLEVVEVKSRQITIRWE-PFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436
Query: 255 RNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSIST---VPNAVTSLSKQDWT-N 310
++ T L P T + + R Q + + T +P AV + S Q T
Sbjct: 437 TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496
Query: 311 STIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQ--STSG--------TDITLKELEAG 360
I L+W P Y +++ DP + SG T L G
Sbjct: 497 EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556
Query: 361 SLYHLTVWAERNEVRG---YNSTLTAATAPNEVTDLQNET---QTKNSVMLWWKAPGDPH 414
+ Y T+ A + G N T +AP+ + + ET QT N+V + K
Sbjct: 557 TTYSFTIRASTAKGFGPPATNQFTTKISAPS-MPAYELETPLNQTDNTVTVMLKPAHSRG 615
Query: 415 SQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETW--YKVEA-LEPGTLYNFTVWAER 471
+ + VY + + PRR T +T E Y V + +L N +
Sbjct: 616 APVSVYQIV-VEEERPRR-----------TKKTTEILKCYPVPIHFQNASLLNSQYYFAA 663
Query: 472 NDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFEL--EVGGQRGSQ 529
A S Q+ T D T GY W+ P Y+++ + + + +
Sbjct: 664 EFPADSLQAAQPFTIGDNKTYN-------GY-----WNTPLLPYKSYRIYFQAASRANGE 711
Query: 530 DRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLI 589
+ C V V G A P + K H+V IAG GILLF+I
Sbjct: 712 TKIDC---VQVATKGAATPKPVP-----EPEKQTDHTVK--------IAGVIAGILLFVI 755
Query: 590 LVGLLIFFLKRRNKKKQQK 608
+ ++ +K+R K++K
Sbjct: 756 IFLGVVLVMKKRKLAKKRK 774
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 221 bits (564), Expect = 2e-57
Identities = 124/349 (35%), Positives = 193/349 (55%), Gaps = 26/349 (7%)
Query: 574 AGVIAGAFVGILLFLILVGLLIFFLKRRN-------------KKKQQKPELRDLVFSSPG 620
A ++A + + +++F+I+V ++ F K + + + +P+ L+ SP
Sbjct: 145 AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPS 204
Query: 621 D------IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRN 674
+P + + + + D N F +++ L + AS EN KNRY N
Sbjct: 205 TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
Query: 675 VLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQS 734
+LPYD SRV L P+ P SDYINASF+ G +FIA QGP +TV DFWR++WEQ +
Sbjct: 265 ILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT 324
Query: 735 HTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK 794
T+VM+TN E KC YWP D T+G++RV++ V+ ++TVR+ + QV +
Sbjct: 325 ATIVMVTNLKERKECKCAQYWP-DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMT 383
Query: 795 TLS----VRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTG 850
+ QFH+ +WPD GVP +P +L F + ++ Q G +VHCSAGVGRTG
Sbjct: 384 NRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTG 441
Query: 851 TLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 899
T + +D +L + +E + + FV ++R R MVQT+ QYVF++Q +L
Sbjct: 442 TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALL 490
Score = 199 bits (506), Expect = 1e-50
Identities = 102/267 (38%), Positives = 160/267 (59%), Gaps = 5/267 (1%)
Query: 638 SNCGFADKYQQLSLVGHSQSQM-VASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDY 696
SN G +++++L+ + +M + N KNR ++PY+++RV + E +DY
Sbjct: 520 SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDY 579
Query: 697 INASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWP 756
+NASF+ G +IA+QGPL T+ DFWR++WE +S ++VMLT E G+ KC YWP
Sbjct: 580 VNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP 639
Query: 757 LDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPD 816
D ++G + V L EE E++TVR+LL+ E K+ +RQFH+ WP+ G+PS
Sbjct: 640 SDGL-VSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGK 698
Query: 817 TLLAFWRMLRQWLDQTMEGGPPI-VHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVR 875
+++ +++ Q G PI VHCSAG GRTGT AL +L ++++EG+L F V+
Sbjct: 699 GMISIIAAVQK--QQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVK 756
Query: 876 KMRESRPLMVQTEAQYVFLHQCILRFL 902
+R RP MVQT QY F ++ + ++
Sbjct: 757 SLRLQRPHMVQTLEQYEFCYKVVQEYI 783
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,700,918
Number of Sequences: 37866
Number of extensions: 1976784
Number of successful extensions: 7598
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 152
Number of HSP's successfully gapped in prelim test: 84
Number of HSP's that attempted gapping in prelim test: 4972
Number of HSP's gapped (non-prelim): 1276
length of query: 937
length of database: 18,247,518
effective HSP length: 112
effective length of query: 825
effective length of database: 14,006,526
effective search space: 11555383950
effective search space used: 11555383950
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.