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Search of human proteins with 241896924
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|241896924 protein tyrosine phosphatase, receptor type, H
isoform 1 precursor [Homo sapiens]
(1115 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|241896924 protein tyrosine phosphatase, receptor type, H isof... 2309 0.0
gi|241896926 protein tyrosine phosphatase, receptor type, H isof... 1847 0.0
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 387 e-107
gi|13677214 receptor-type protein tyrosine phosphatase O isoform... 290 5e-78
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 280 4e-75
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 280 4e-75
gi|4506323 receptor-type protein tyrosine phosphatase O isoform ... 279 9e-75
gi|13677222 receptor-type protein tyrosine phosphatase O isoform... 268 2e-71
gi|13677218 receptor-type protein tyrosine phosphatase O isoform... 268 2e-71
gi|13677220 receptor-type protein tyrosine phosphatase O isoform... 266 6e-71
gi|13677216 receptor-type protein tyrosine phosphatase O isoform... 266 6e-71
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 239 1e-62
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 239 1e-62
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 238 2e-62
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 237 4e-62
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 236 9e-62
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 236 9e-62
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 236 9e-62
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 236 9e-62
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 235 2e-61
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 232 1e-60
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 232 1e-60
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 232 2e-60
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 232 2e-60
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 232 2e-60
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 231 4e-60
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 223 6e-58
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 223 8e-58
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 223 8e-58
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 221 2e-57
>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
precursor [Homo sapiens]
Length = 1115
Score = 2309 bits (5984), Expect = 0.0
Identities = 1115/1115 (100%), Positives = 1115/1115 (100%)
Query: 1 MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN 60
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN
Sbjct: 1 MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN 60
Query: 61 SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN 120
SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN
Sbjct: 61 SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN 120
Query: 121 PVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEP 180
PVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEP
Sbjct: 121 PVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEP 180
Query: 181 GCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNST 240
GCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNST
Sbjct: 181 GCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNST 240
Query: 241 YCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPV 300
YCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPV
Sbjct: 241 YCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPV 300
Query: 301 RNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGC 360
RNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGC
Sbjct: 301 RNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGC 360
Query: 361 LYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYW 420
LYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYW
Sbjct: 361 LYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYW 420
Query: 421 VEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTS 480
VEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTS
Sbjct: 421 VEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTS 480
Query: 481 LSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSL 540
LSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSL
Sbjct: 481 LSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSL 540
Query: 541 YHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWV 600
YHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWV
Sbjct: 541 YHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWV 600
Query: 601 QWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLC 660
QWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLC
Sbjct: 601 QWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLC 660
Query: 661 ASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLG 720
ASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLG
Sbjct: 661 ASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLG 720
Query: 721 LGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRN 780
LGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRN
Sbjct: 721 LGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRN 780
Query: 781 KKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVAS 840
KKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVAS
Sbjct: 781 KKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVAS 840
Query: 841 ASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTV 900
ASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTV
Sbjct: 841 ASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTV 900
Query: 901 GDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTV 960
GDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTV
Sbjct: 901 GDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTV 960
Query: 961 RELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHC 1020
RELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHC
Sbjct: 961 RELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHC 1020
Query: 1021 SAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
SAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
Sbjct: 1021 SAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
Query: 1081 QQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV 1115
QQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV
Sbjct: 1081 QQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV 1115
>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform 2
precursor [Homo sapiens]
Length = 937
Score = 1847 bits (4784), Expect = 0.0
Identities = 895/909 (98%), Positives = 896/909 (98%)
Query: 207 AHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDG 266
A NP RNL VE QTTSSISLSWEVPDG D QNS Y VQCTGDGG TETRNTT T VTVDG
Sbjct: 29 APNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDG 88
Query: 267 LGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQ 326
LGPGSLYTCSVWVEKDGVNSSV VT+ATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQ
Sbjct: 89 LGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQ 148
Query: 327 NSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAP 386
NSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAP
Sbjct: 149 NSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAP 208
Query: 387 NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLE 446
NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLE
Sbjct: 209 NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLE 268
Query: 447 PGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSY 506
PGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSY
Sbjct: 269 PGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSY 328
Query: 507 SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN 566
SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN
Sbjct: 329 SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN 388
Query: 567 EVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTN 626
EVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTN
Sbjct: 389 EVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTN 448
Query: 627 ETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIW 686
ETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIW
Sbjct: 449 ETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIW 508
Query: 687 SCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVV 746
SCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVV
Sbjct: 509 SCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVV 568
Query: 747 CHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFA 806
CHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFA
Sbjct: 569 CHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFA 628
Query: 807 DHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPI 866
DHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPI
Sbjct: 629 DHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPI 688
Query: 867 HEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGR 926
HEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGR
Sbjct: 689 HEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGR 748
Query: 927 VKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPD 986
VKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPD
Sbjct: 749 VKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPD 808
Query: 987 HGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLL 1046
HGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLL
Sbjct: 809 HGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLL 868
Query: 1047 GPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVA 1106
GPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVA
Sbjct: 869 GPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVA 928
Query: 1107 AIQAHKLEV 1115
AIQAHKLEV
Sbjct: 929 AIQAHKLEV 937
Score = 676 bits (1745), Expect = 0.0
Identities = 349/558 (62%), Positives = 400/558 (71%), Gaps = 18/558 (3%)
Query: 1 MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN 60
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN
Sbjct: 1 MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN 60
Query: 61 SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN 120
SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN
Sbjct: 61 SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN 120
Query: 121 PVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEP 180
PVRNL VEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVD LEP
Sbjct: 121 PVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEP 180
Query: 181 GCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNST 240
GCLY FS+WVGKNGINSSRETRNATTA NPVRNL +E QT SSI+L WEVPDG PQ+ T
Sbjct: 181 GCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYT 240
Query: 241 YCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPV 300
Y V+ TGDGG TETRNTT+T VT + L PG+LYT SVW EK+G S + V+ +T PN V
Sbjct: 241 YWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAV 300
Query: 301 RNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG-GRAGTRSTAHTNITVDRLEPG 359
+L+ + TNS+IAL W P GP + +Y V + +G T+ST+ T+IT+ LE G
Sbjct: 301 TSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAG 360
Query: 360 CLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTY 419
LY +VW +N + T A TAPN V +L ETQT +S+ L W+ P P+ Q Y Y
Sbjct: 361 SLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVY 420
Query: 420 WVEYTGDGGG-----------TETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQN 468
WV++ G +T T T E LEPGTLY F+VWAE+N S Q+
Sbjct: 421 WVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQS 480
Query: 469 VSISTVPNAVTSLS-KQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSG 527
+ ST P+ VT S + L W+ PQG G ++ V G + +S+ G
Sbjct: 481 LCASTYPDTVTITSCVSTSAGYGVNLIWSCPQG-GYEAFELEVG----GQRGSQDRSSCG 535
Query: 528 TDITLKELEAGSLYHLTV 545
+++ L Y T+
Sbjct: 536 EAVSVLGLGPARSYPATI 553
Score = 71.2 bits (173), Expect = 5e-12
Identities = 61/212 (28%), Positives = 90/212 (42%), Gaps = 19/212 (8%)
Query: 537 AGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLY 596
AG+ L VW + + T A APN +L ETQT +S+ L W+ P SQ
Sbjct: 2 AGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNS 61
Query: 597 VYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASST 656
YWVQ G +T T T V+ L PG+LY +VW E++ V SS
Sbjct: 62 NYWVQCTGDG-----------GTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSV 110
Query: 657 QSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQG---GYEAFELEVGGQRG-SQDRSSC 712
++ +T P+ V V + L W P G + +E G G + RS+
Sbjct: 111 GTVTTATAPNPVR-NLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTA 169
Query: 713 GEAVSVLGLGPARSYPATITTIWDGMKVVSHS 744
++V L P Y + ++W G ++ S
Sbjct: 170 HTNITVDRLEPGCLY---VFSVWVGKNGINSS 198
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 387 bits (994), Expect = e-107
Identities = 305/1060 (28%), Positives = 474/1060 (44%), Gaps = 94/1060 (8%)
Query: 82 TNVTVDGLGPGSLYTCSVWVEK----DGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIAL 137
T V + GL PG+ Y +V+ + +G ++ T A V + + A +S+ L
Sbjct: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISA---TSLTL 384
Query: 138 TWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINS 197
W+V D N TY + G+ + + + + GL Y ++ I
Sbjct: 385 IWKVSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEG 443
Query: 198 SRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDG-GRTETRN 256
+ T PV + RV +T+ I L+W D ++ + T +G G +
Sbjct: 444 TPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDA-----ESFQMHITQEGAGNSRVEI 498
Query: 257 TTDTRVTVDGLGPGSLYTCSVWVEK--DGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIA 314
TT+ + + GL PG+ Y C V K +G + V + T P+ V ++ V T + +
Sbjct: 499 TTNQSIIIGGLFPGTKY-CFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMW 557
Query: 315 LTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGIN 374
L W+ PDG +E T A IT+ L PG LY ++ + +
Sbjct: 558 LDWKSPDGASEYVYHLVIESKHGSNHTSTYDKA---ITLQGLIPGTLYNITISPEVDHVW 614
Query: 375 SSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETR 433
+ T P+ V N+ + T T ++ L W+ D P Y +E G+ T+
Sbjct: 615 GDPNSTAQYTRPSNVSNIDVSTNTTAA-TLSWQNFDDASPTYSYCLLIEKAGNSSNA-TQ 672
Query: 434 NTTN---TSVTAERLEPGTLYTFSVWAEKNGARGSRQ--NVSISTVPNAVTSLSKQDWTN 488
T+ T T L PG+ YT ++A+ S + S T P ++ S +
Sbjct: 673 VVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPK 732
Query: 489 S-TIALRWTAPQGPG-----QSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYH 542
+ L+WT P G + S W + + T++T L + Y+
Sbjct: 733 EPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTY--LNFSTSYN 790
Query: 543 L---TVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTK-NSVMLWWKAPGDPHSQLYVY 598
+ TV + N+ T T P N T NSV + + H + Y
Sbjct: 791 ISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAY 850
Query: 599 WV--QWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASST 656
V GHP + Y E + G + + R + +
Sbjct: 851 AVILTTGEAGHPS---------------ADVLKYTYEDFKKGASDTYVTYLIRTEEKGRS 895
Query: 657 QSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAV 716
QSL + + + + +T Y L P G Y A
Sbjct: 896 QSL-SEVLKYEIDVGNESTTLGYYNGKLE---PLGSYRA--------------------- 930
Query: 717 SVLGLGPARSYPATITTIWDGMKVVSHS----VVCHTESAGVIAGAFVGIL---LFLILV 769
V G +P I VS S V + GVI GA G + L ++ V
Sbjct: 931 CVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTV 990
Query: 770 GLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSL 829
G IF+ K+R K + + I E+F + +K + DSNCGFA++Y+ L L
Sbjct: 991 GGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKL 1050
Query: 830 VGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEF 889
VG SQ + A +EN KNRY NVLPYD SRV L + DYINA++MPG S ++F
Sbjct: 1051 VGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDF 1109
Query: 890 IATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTL 949
IATQGPLP T+ DFWR+VWE+ + ++MLT C+E GR KCE YWP Q +G + V +
Sbjct: 1110 IATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAM 1168
Query: 950 VGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQ 1009
E V+ WT+R+ + ++ ++ +RQFH+ +WPDHGVP + D L+ F ++R ++ Q
Sbjct: 1169 TSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQ 1228
Query: 1010 TMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQY 1069
+ P +VHCSAGVGRTGT IA+D L+ Q+++E + + V +R RPLMVQTE QY
Sbjct: 1229 SPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQY 1288
Query: 1070 VFLHQCILRFLQQSAQAPAEKEVPYEDVENL-IYENVAAI 1108
VFL+QC+L ++ +Q ++ ++ Y++ + IYEN+A +
Sbjct: 1289 VFLNQCVLDIVR--SQKDSKVDLIYQNTTAMTIYENLAPV 1326
Score = 139 bits (349), Expect = 2e-32
Identities = 172/742 (23%), Positives = 285/742 (38%), Gaps = 71/742 (9%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGL 89
P+P ++ + + +++ L+W+ D S+ + T + N+T GL
Sbjct: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNIT--GL 176
Query: 90 GPGSLYTCSVWVEKDGVNSSVG----TVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGP 145
P + Y S+ G+ + + T P PV +LRV AL+W +G
Sbjct: 177 RPATSYVFSI---TPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNG- 232
Query: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNAT 205
++ V G + + + GL+PG Y + ++ ++
Sbjct: 233 ---TASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYL----------LQSNK 279
Query: 206 TAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVD 265
T +P L E +S + T P + V G + + + DT V +
Sbjct: 280 TKGDP---LGTEGGLDASNTERSRAGSPTAPVHDESLV---GPVDPSSGQQSRDTEVLLV 333
Query: 266 GLGPGSLYTCSVWVEK----DGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPD 321
GL PG+ Y +V+ + +G ++E T+A V + + A +S+ L W+V D
Sbjct: 334 GLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISA---TSLTLIWKVSD 390
Query: 322 GPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRN 381
N TY + G+ + + + + L Y +V I +
Sbjct: 391 NESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQ 449
Query: 382 ATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGG-TETRNTTNTSV 440
T P PV + + + + I L W D ++ + T +G G + TTN S+
Sbjct: 450 VHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE-----SFQMHITQEGAGNSRVEITTNQSI 504
Query: 441 TAERLEPGTLYTFSVWAE-KNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQ 499
L PGT Y F + + NG G+ + V TVP+AV + T + + L W +P
Sbjct: 505 IIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPD 564
Query: 500 GPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTL 559
G S Y Y + V E ST ITL+ L G+LY++T+ E + V G ++
Sbjct: 565 GA--SEYVYHL--VIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNST 620
Query: 560 TAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWV 619
T P+ V+++ T T + + W D S Y Y + G+ +N
Sbjct: 621 AQYTRPSNVSNIDVSTNTTAATLSWQNF--DDASPTYSYCLLIEKAGN-------SSNAT 671
Query: 620 NQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQ----SLCASTYPDTVTITSCVS 675
+ T V L PG+ Y ++A+ D S + S C T P ++ C
Sbjct: 672 QVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFC--TDPASMASFDCEV 729
Query: 676 TSAGYGVNLIWSCPQGGYEAFELEV--GGQRGSQDRSSCGE------AVSVLGLGPARSY 727
+ L W+CP G FELEV G + SC V L + SY
Sbjct: 730 VPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSY 789
Query: 728 PATITTIWDGMKVVSHSVVCHT 749
+ITT+ G C T
Sbjct: 790 NISITTVSCGKMAAPTRNTCTT 811
Score = 104 bits (259), Expect = 5e-22
Identities = 143/623 (22%), Positives = 241/623 (38%), Gaps = 66/623 (10%)
Query: 68 TGDGGTTETRNTTATNVTVDGLGPGSLYT-CSVWVEKDGVNSSVGT-------------- 112
TG+ G T+ +T + +G G + T S E G N S+ T
Sbjct: 53 TGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQK 112
Query: 113 VTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH-- 170
++T P+PV +++ + + +++ LTW+ D + Y V++ + + T + H
Sbjct: 113 TPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYK-YVVKHKMENEK--TITVVHQP 169
Query: 171 -TNITVDGLEPGCLYAFSMWVG-KNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSW 228
NIT GL P Y FS+ G N T PV +LRV +LSW
Sbjct: 170 WCNIT--GLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSW 227
Query: 229 EVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSV 288
+GT ++ V G E + +V + GL PG Y + ++
Sbjct: 228 SNGNGT----ASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYL--------- 274
Query: 289 EIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH 348
+ ++ T +P L E ++S E P + G + + +
Sbjct: 275 -LQSNKTKGDP---LGTEGGLDAS---NTERSRAGSPTAPVHDESLVGPVDPSSGQQSRD 327
Query: 349 TNITVDRLEPGCLYVFSVW-VGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWE 407
T + + LEPG Y +V+ NG + T V ++ + +S+ L W+
Sbjct: 328 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWK 387
Query: 408 VPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQ 467
V D +YTY + G+ + N + L T Y +V G+
Sbjct: 388 VSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPG 446
Query: 468 NVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSG 527
+ + T P V+ + + I L W++ + S+ + +EG + R + T+
Sbjct: 447 FLQVHTPPVPVSDFRVTVVSTTEIGLAWSS-----HDAESFQMHITQEGAGNSRVEITTN 501
Query: 528 TDITLKELEAGSLYHLTVWAE-RNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWK 586
I + L G+ Y + + N G + T+ T P+ V D+ T + L WK
Sbjct: 502 QSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWK 561
Query: 587 APGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVW 646
+P D S+ YVY + SK + N TS T + ++ L PGTLYN T+
Sbjct: 562 SP-DGASE-YVYHLVIESK-----------HGSNHTS-TYDKAITLQGLIPGTLYNITIS 607
Query: 647 AERNDVASSTQSLCASTYPDTVT 669
E + V S T P V+
Sbjct: 608 PEVDHVWGDPNSTAQYTRPSNVS 630
Score = 92.4 bits (228), Expect = 2e-18
Identities = 134/644 (20%), Positives = 245/644 (38%), Gaps = 92/644 (14%)
Query: 145 PDPQNSTYGVEYTGDGGRAGTRSTAH--------------TNITVDGLEPGCLYAF-SMW 189
PDP +T TG+ G STA TN + DG G + +
Sbjct: 44 PDPSVATVA---TGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPE 100
Query: 190 VGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDG 249
G NG + + + ++T +PV +++ + + +++ L+W+ D T Y V+ +
Sbjct: 101 QGSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSND-TAASEYKYVVKHKMEN 159
Query: 250 GRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSV----EIVTSATAPNPVRNLTV 305
+T T + GL P + Y S+ G+ + ++ T P PV +L V
Sbjct: 160 EKTIT-VVHQPWCNITGLRPATSYVFSI---TPGIGNETWGDPRVIKVITEPIPVSDLRV 215
Query: 306 EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFS 365
AL+W +G ++ V G + + + L+PG Y +
Sbjct: 216 ALTGVRKAALSWSNGNG----TASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNIN 271
Query: 366 VWV------------GKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPY 413
++ + G+++S R + A +P +H E+ GP
Sbjct: 272 PYLLQSNKTKGDPLGTEGGLDASNTER--SRAGSPTAPVHDESLV------------GP- 316
Query: 414 PQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAE-KNGARGSRQNVSIS 472
G ++R +T V LEPGT Y +V+++ NG G Q +
Sbjct: 317 ----------VDPSSGQQSR---DTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFR 363
Query: 473 TVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITL 532
T V ++ + + +++ L W S+Y+Y + G TD + S +
Sbjct: 364 TNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVA--GETDSSNLNVSEPRAVI 421
Query: 533 KELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPH 592
L + + Y++TV ++ G L T P V+D + + + L W +
Sbjct: 422 PGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAES 481
Query: 593 SQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAE-RND 651
Q+++ Q+ N ++ T + L PGT Y F + + N
Sbjct: 482 FQMHI-------------TQEGAGN--SRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNG 526
Query: 652 VASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYE-AFELEVGGQRGSQDRS 710
+++++C T P V V + + L W P G E + L + + GS S
Sbjct: 527 TEGASRTVCNRTVPSAVFDIHVVYVTT-TEMWLDWKSPDGASEYVYHLVIESKHGSNHTS 585
Query: 711 SCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGV 754
+ +A+++ GL P Y TI+ D + +S +T + V
Sbjct: 586 TYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNV 629
Score = 57.4 bits (137), Expect = 7e-08
Identities = 71/327 (21%), Positives = 121/327 (37%), Gaps = 35/327 (10%)
Query: 21 SWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTT 80
S T P+ ++ V TT+ + L W+ PDG + ++ T T +
Sbjct: 531 SRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKA 590
Query: 81 ATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWE 140
+T+ GL PG+LY ++ E D V + T P+ V N+ V T ++ L+W+
Sbjct: 591 ---ITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAA-TLSWQ 646
Query: 141 VPDGPDPQNS-TYGVEYTGDGGRAGTRST--AHTNITVDGLEPGCLYAFSMWVGKNGINS 197
D P S +E G+ A T T+ TV L PG Y ++
Sbjct: 647 NFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIK 706
Query: 198 SRETRNATTAHNPVRNLRVEAQTT---SSISLSWEVPDGTDP-----------QNSTYCV 243
S E + +P + + ++ L W P G + N+T+
Sbjct: 707 SLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLE 766
Query: 244 QCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGV------NSSVEIVTSATAP 297
C+ + G T+ R V L + Y S+ G N+ +T P
Sbjct: 767 SCSSENG-------TEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPP 819
Query: 298 NPVRNLTVEAQTNSSIALT-WEVPDGP 323
+ N+T + + + + +E GP
Sbjct: 820 DGSPNITSVSHNSVKVKFSGFEASHGP 846
>gi|13677214 receptor-type protein tyrosine phosphatase O isoform a
precursor [Homo sapiens]
Length = 1216
Score = 290 bits (742), Expect = 5e-78
Identities = 224/766 (29%), Positives = 343/766 (44%), Gaps = 69/766 (9%)
Query: 353 VDRLEPGCLYVFSVWVGKNG-INSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDG 411
++ L PG Y +++ K I + P +++L + +++ L W P
Sbjct: 496 IENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYL 555
Query: 412 PYPQDYTYWVEYTGDGGGTETRNT---------TNTSVTAERLEPGTLYTFSV----WAE 458
+ Y + Y T T SV L P Y F V W +
Sbjct: 556 GVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGD 615
Query: 459 KNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSW--VREG 516
+ +S T P A ++ ++ NS + + WT S+S + W V EG
Sbjct: 616 PELSCCDSSTISFITAPVA-PEITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEG 674
Query: 517 MTDPRTQSTSGTDITLKELEAGSLYHLTVWA--ERNEVRGYNSTLTAATAPNEVTDLQNE 574
+ T + L G +Y+L+V A ER + AP + N+
Sbjct: 675 KKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPAPPKSLFAVNK 734
Query: 575 TQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEA 634
TQT SV L W G + + + Q + Q+P A + + +
Sbjct: 735 TQT--SVTLLWVEEGV--ADFFEVFCQQVGSSQKTKLQEPVA--------VSSHVVTISS 782
Query: 635 LEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYE 694
L P T YN +V + +D S + ST +T V I S G
Sbjct: 783 LLPATAYNCSVTSFSHDSPSVPTFIAVSTM-----VTEMNPNVVVISVLAILSTLLIGLL 837
Query: 695 AFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGV 754
L + ++ Q CG V R + W S+
Sbjct: 838 LVTLIILRKKHLQMARECGAGTFVNFASLERD--GKLPYNW------RRSIF-------- 881
Query: 755 IAGAFVGILLFLILVG-LLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNE 813
AF+ +L + LL F++ +K +K +L + + +DF +++
Sbjct: 882 ---AFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTN-------PVQLDDFDAYIKDMA 931
Query: 814 RDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSD 873
+DS+ F+ ++++L L+G A N KNRY N+LPYD+SRV L ++EE G+D
Sbjct: 932 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 991
Query: 874 YINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYW 933
YINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT C E RVKC+HYW
Sbjct: 992 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 1051
Query: 934 PLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVP--S 991
P +P +G + V ++ EE ++W R + +E + V F+Y AWPDHGVP +
Sbjct: 1052 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHFNYTAWPDHGVPTAN 1109
Query: 992 SPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSF 1051
+ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL+ ++ +
Sbjct: 1110 AAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGL 1167
Query: 1052 VRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 1097
V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 1168 VSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 1213
Score = 37.4 bits (85), Expect = 0.080
Identities = 50/229 (21%), Positives = 91/229 (39%), Gaps = 25/229 (10%)
Query: 261 RVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVP 320
RVT+ G L C +S++ +T+ AP +T NS + ++W
Sbjct: 607 RVTMVTWGDPELSCCD--------SSTISFITAPVAPE----ITSVEYFNSLLYISWTYG 654
Query: 321 DGPDPQNSTYGVEY--TGDGGRAGTRSTAHTNIT-VDRLEPGCLYVFSVWVGKNGINSSR 377
D + + + + +G + +S +T + L PG +Y SV +++
Sbjct: 655 DDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTS 714
Query: 378 ETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTN 437
R P P ++L +T +S+ L W V +G + + + G T+ +
Sbjct: 715 MLRLVKLEPAPPKSLFAVNKTQTSVTLLW-VEEG-VADFFEVFCQQVGSSQKTKLQEPVA 772
Query: 438 TS---VTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTV-----PNAV 478
S VT L P T Y SV + + + +++ST+ PN V
Sbjct: 773 VSSHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVV 821
Score = 32.0 bits (71), Expect = 3.4
Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 8/98 (8%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN---VTV 86
P P ++L +T +S++L W V +G+ + + Q G T+ + A + VT+
Sbjct: 723 PAPPKSLFAVNKTQTSVTLLW-VEEGV-ADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI 780
Query: 87 DGLGPGSLYTCSVWV---EKDGVNSSVGTVTTATAPNP 121
L P + Y CSV + V + + T T NP
Sbjct: 781 SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNP 818
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 280 bits (717), Expect = 4e-75
Identities = 152/372 (40%), Positives = 217/372 (58%), Gaps = 24/372 (6%)
Query: 753 GVIAGAFVGILLFLILVGLLIFFLKRRNKKK-QQKPELR-----------DLVFSSPGD- 799
G I G G+ L +LV ++ + R+ +++P R L G+
Sbjct: 1836 GAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNR 1895
Query: 800 -----IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVL 854
I F H K + DSN + +Y++L VG +QS +A EN KNRY N+L
Sbjct: 1896 KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNIL 1955
Query: 855 PYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHT 914
PYD +RV L + ++P SDYINAS++PG +E+I TQGPLP T DFW++VWEQ H
Sbjct: 1956 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 2015
Query: 915 LVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE-QKT 973
+VM+T C+E GRVKC+HYWP D +G L + ++ E V+ WT+RE + E+
Sbjct: 2016 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 2075
Query: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
+R FHY WPDHGVP + +L+ F R +R +++++ GP +VHCSAGVGRTGT IAL
Sbjct: 2076 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 2135
Query: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVP 1093
D +L+QL S+ + + V +R R MVQTE QYV+LHQC+ R + ++ + +E+E P
Sbjct: 2136 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV-RDVLRARKLRSEQENP 2194
Query: 1094 YEDVENLIYENV 1105
IYENV
Sbjct: 2195 LFP----IYENV 2202
Score = 99.0 bits (245), Expect = 2e-20
Identities = 169/741 (22%), Positives = 282/741 (38%), Gaps = 83/741 (11%)
Query: 28 PAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG-----GTTETRNTTAT 82
P P ++ E T++S+ + W G + ++Y VQ + G +T+
Sbjct: 328 PLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQESTSWN 384
Query: 83 NVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVP 142
T L GS Y ++ G S +T P+PV+++ + + N S+ ++W
Sbjct: 385 EYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLLISWSHG 443
Query: 143 DGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETR 202
G + + + G G T+ GL PG LY ++ G+ + R +
Sbjct: 444 SG-NVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYR-WK 501
Query: 203 NATTAHNPVRNLRVEAQ-TTSSISLSWEVPDG-TDPQNSTYCVQCTGDGGRTETRNTTDT 260
TA V NL+V + +S+ + W+ P G D N T + T R T+T
Sbjct: 502 LVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITET 561
Query: 261 RVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNS---SIALTW 317
L PG LY +V G S+ ++ T P+ V NL EA N S+ ++W
Sbjct: 562 H--FKELVPGRLYQVTVSC-VSGELSAQKMAVGRTFPDKVANL--EANNNGRMRSLVVSW 616
Query: 318 EVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDR-----------LEPGCLYVFSV 366
P G Q Y + D S NITV + L PG Y V
Sbjct: 617 SPPAGDWEQ---YRILLFND-------SVVLLNITVGKEETQYVMDDTGLVPGRQYEVEV 666
Query: 367 WVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGD 426
V + +S E T P V L ++ +S+++ W+ P W +Y
Sbjct: 667 IVESGNLKNS-ERCQGRTVPLAVLQLRVKHANETSLSIMWQTP-------VAEWEKYIIS 718
Query: 427 GGGTE------TRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTS 480
+ + + T L PG Y +V + + S +V TVP VT
Sbjct: 719 LADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNS-SSVKGRTVPAQVTD 777
Query: 481 L--SKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTD-ITLKELEA 537
L + Q T S++ WT QG + Y V + E + +S T + L++
Sbjct: 778 LHVANQGMT-SSLFTNWTQAQGDVE---FYQVLLIHENVVIKNESISSETSRYSFHSLKS 833
Query: 538 GSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVM--LWWKAPGDPHSQL 595
GSLY + V + + T P+ V+ + +N + W APGD +
Sbjct: 834 GSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDN-- 891
Query: 596 YVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASS 655
Y V + G+ Q+ + ++ R +L PG LY T+ +
Sbjct: 892 --YEVTLS-----HDGKVVQSLVIAKSVRE----CSFSSLTPGRLYTVTITTRSGKYENH 940
Query: 656 TQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEA 715
+ S T PD V S +++ + + W G ++ +E+ + + S ++
Sbjct: 941 SFSQ-ERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKS 999
Query: 716 VS---VLGLGPARSYPATITT 733
+ + L P R Y T+TT
Sbjct: 1000 ENECVFVQLVPGRLYSVTVTT 1020
Score = 86.7 bits (213), Expect = 1e-16
Identities = 166/739 (22%), Positives = 270/739 (36%), Gaps = 91/739 (12%)
Query: 31 NPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETR--NTTATNVTVDG 88
N GRN +S+SW + G NY V + DG ++ + +
Sbjct: 871 NSGRN--------DYLSVSWLLAPG---DVDNYEVTLSHDGKVVQSLVIAKSVRECSFSS 919
Query: 89 LGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSS-IALTWEVPDGPDP 147
L PG LYT ++ + G + T P+ V+ + V S + ++W G
Sbjct: 920 LTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFD 978
Query: 148 QNSTYGVEYTGDGGRAGTRST--AHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNAT 205
Y V T+S + L PG LY+ ++ K+G + E N
Sbjct: 979 H---YEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTT-KSGQYEANEQGNGR 1034
Query: 206 TAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTE-----TRNTTDT 260
T PV++L + ++T + ++W +G Q Y +Q + + T+
Sbjct: 1035 TIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQ---YEIQLLFNDMKVFPPFHLVNTATEY 1091
Query: 261 RVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQ-TNSSIALTWEV 319
R T L PG Y V V S + T P+ V+N+ + S+ + W
Sbjct: 1092 RFT--SLTPGRQYKILVLTISGDVQQSA-FIEGFTVPSAVKNIHISPNGATDSLTVNW-T 1147
Query: 320 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRET 379
P G D + T + T T RLE G Y + +G ++
Sbjct: 1148 PGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI-ASVSGSLKNQIN 1206
Query: 380 RNATTAPNPVRNLHMETQTNS-SIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETRNTTN 437
T P V+ + + +S S+ + W+ G + D E G RNT+
Sbjct: 1207 VVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE-----NGILLRNTSE 1261
Query: 438 TSVTA----ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIAL 493
+ T E L PG Y + G TVP AVT L + + ++
Sbjct: 1262 PATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSF 1321
Query: 494 RWTAPQGPGQSSYSYWV-----SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAE 548
RWTA +G S Y+ ++ + DP QS S + L G +Y + +
Sbjct: 1322 RWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFS-----FQNLLQGRMYKMVIVTH 1375
Query: 549 RNEVRGYNSTLTAATAPNEVTDLQ--NETQTKNSVMLWWKAPGD-PHSQLYVYWVQWASK 605
E+ S + T P V+ L+ N T + W A GD +L +Y K
Sbjct: 1376 SGELSN-ESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKK 1434
Query: 606 GHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVAS--STQSLCAST 663
NW ++ + T ++ + L PG Y V D+++ + +S A +
Sbjct: 1435 ----------ENWKDK----DLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPS 1480
Query: 664 YPDTVTITSCVSTSAGYGVNLIWSCPQG--GYEAFELE------VGGQRGSQDRSSCGEA 715
P ++ +TS + + W P Y FEL+ + +R S G
Sbjct: 1481 PPSLMSFADIANTS----LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI 1536
Query: 716 VSVLGLGPARSYPATITTI 734
V GL P RSY + T+
Sbjct: 1537 --VYGLRPGRSYQFNVKTV 1553
Score = 74.7 bits (182), Expect = 5e-13
Identities = 104/467 (22%), Positives = 184/467 (39%), Gaps = 45/467 (9%)
Query: 291 VTSATAPNPVRNLTV--EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG-----GRAGT 343
V T P P V E T++S+ + W G + ++Y V+ + G
Sbjct: 322 VVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQ 378
Query: 344 RSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIA 403
ST+ T L G Y ++ G S N +T P+PV+++ + T+ N S+
Sbjct: 379 ESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLL 437
Query: 404 LCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNTTNTSVTAERLEPGTLYTFSVWAEK 459
+ W G + Y + G GG ++ TS L PG LY +V E
Sbjct: 438 ISWSHGSGNVER---YRLMLMDKGILVHGGVVDKHA--TSYAFHGLTPGYLYNLTVMTEA 492
Query: 460 NGARGSRQNVSISTVPNAVTSLS-KQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMT 518
G + R + + T P V++L D + +++ ++W P G SY+ +S + +
Sbjct: 493 AGLQNYRWKL-VRTAPMEVSNLKVTNDGSLTSLKVKWQRPPG-NVDSYNITLSH-KGTIK 549
Query: 519 DPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQ-NETQT 577
+ R + T+ KEL G LY +TV E+ + T P++V +L+ N
Sbjct: 550 ESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAV-GRTFPDKVANLEANNNGR 608
Query: 578 KNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE--AL 635
S+++ W P Q + + +N T ET Y ++ L
Sbjct: 609 MRSLVVSWSPPAGDWEQYRILLF------------NDSVVLLNITVGKEETQYVMDDTGL 656
Query: 636 EPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEA 695
PG Y V E ++ +S + C + V + ++++W P +E
Sbjct: 657 VPGRQYEVEVIVESGNLKNSER--CQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEK 714
Query: 696 FELEVGGQ---RGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMK 739
+ + + + + S + + L P R Y AT+T+I +K
Sbjct: 715 YIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLK 761
Score = 70.5 bits (171), Expect = 9e-12
Identities = 139/709 (19%), Positives = 268/709 (37%), Gaps = 44/709 (6%)
Query: 45 SISLSWEVPDGLDSQNSNYWVQCTGDG----GTTETRNTTATNVTVDGLGPGSLYTCSVW 100
S+ +SW P G Q Y + D T + T + GL PG Y V
Sbjct: 611 SLVVSWSPPAGDWEQ---YRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVI 667
Query: 101 VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
VE + +S T P V LRV+ +S+++ W+ P + Y +
Sbjct: 668 VESGNLKNSE-RCQGRTVPLAVLQLRVKHANETSLSIMWQTPVA---EWEKYIISLADRD 723
Query: 161 GRAGTRSTAHT--NITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEA 218
+S + T L PG Y ++ + +S + T V +L V
Sbjct: 724 LLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQ-VTDLHVAN 782
Query: 219 Q-TTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSV 277
Q TSS+ +W G D + + + E+ ++ +R + L GSLY+ V
Sbjct: 783 QGMTSSLFTNWTQAQG-DVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVV 841
Query: 278 WVEKDGVNSSVEIVTSATAPNPVRNLTV-EAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 336
G++S +V T P+ V +TV + N ++++W + G D N + + G
Sbjct: 842 TTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPG-DVDNYEVTLSHDG 900
Query: 337 DGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMET 396
++ + + + L PG LY ++ ++G + T P+ V+ + +
Sbjct: 901 KVVQSLVIAKSVRECSFSSLTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSN 959
Query: 397 QTNSS-IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSV 455
S + + W G + Y ++ + T++ + +L PG LY+ +V
Sbjct: 960 SARSDYLRVSWVHATGDF-DHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTV 1018
Query: 456 WAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVRE 515
K+G + + + T+P V L+ ++ + + + W+ G Y + +
Sbjct: 1019 -TTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANG-DVDQYEIQLLFNDM 1076
Query: 516 GMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNET 575
+ P + T+ L G Y + V +V+ ++ + T P+ V ++
Sbjct: 1077 KVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQ-QSAFIEGFTVPSAVKNIHISP 1135
Query: 576 Q--TKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE 633
T + + W GD S Y V ++ H ++ +QT + +
Sbjct: 1136 NGATDSLTVNWTPGGGDVDS----YTV--SAFRHSQKVD-------SQTIPKHVFEHTFH 1182
Query: 634 ALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGY 693
LE G Y + A + + ++ T P +V + + Y + + W G
Sbjct: 1183 RLEAGEQYQIMI-ASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVA 1241
Query: 694 EAFELEVGGQRGSQDRSSCGEAVS----VLGLGPARSYPATITTIWDGM 738
E +++ + + G R++ A + L P + Y I T+ G+
Sbjct: 1242 ERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGL 1290
Score = 65.5 bits (158), Expect = 3e-10
Identities = 114/577 (19%), Positives = 204/577 (35%), Gaps = 35/577 (6%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTET---RNTTATNVTV 86
P P ++LT+ ++T + ++W G + Y +Q + TAT
Sbjct: 1037 PEPVKDLTLRNRSTEDLHVTW---SGANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRF 1093
Query: 87 DGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQ-TNSSIALTWEVPDGP 145
L PG Y V V S + T P+ V+N+ + S+ + W P G
Sbjct: 1094 TSLTPGRQYKILVLTISGDVQQS-AFIEGFTVPSAVKNIHISPNGATDSLTVNW-TPGGG 1151
Query: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNAT 205
D + T + T T LE G Y + + + T
Sbjct: 1152 DVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRT 1211
Query: 206 TAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVD 265
+ + A ++ S+ +SW+ G + + G R + T + +
Sbjct: 1212 VPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFE 1271
Query: 266 GLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDP 325
L PG Y + G+ S T P V +L + + ++ W +G
Sbjct: 1272 DLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEG--- 1328
Query: 326 QNSTYGVEYTGDGGRAGTRSTAH---TNITVDRLEPGCLYVFSVWVGKNGINSSRETRNA 382
+ S Y + G R+ + + L G +Y V V +G S+
Sbjct: 1329 ELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKM-VIVTHSGELSNESFIFG 1387
Query: 383 TTAPNPVRNLH-METQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVT 441
T P V +L T S+ W G D+ ++ + GT+ N + +T
Sbjct: 1388 RTVPASVSHLRGSNRNTTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLT 1443
Query: 442 AER---LEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAP 498
R L PG Y V +G ++ T P+ + +S D N+++A+ W P
Sbjct: 1444 EWRFQGLVPGRKYVLWV-VTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWKGP 1502
Query: 499 QGPGQSSYS-YWVSWV-REGMT--DPRTQSTSGTDITLKELEAGSLYHLTV-WAERNEVR 553
P + Y+ + + W+ R+ +T +P S I + L G Y V + +
Sbjct: 1503 --PDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI-VYGLRPGRSYQFNVKTVSGDSWK 1559
Query: 554 GYNSTL--TAATAPNEVTDLQNETQTKNSVMLWWKAP 588
Y+ + + T P+++ +L Q ++ W P
Sbjct: 1560 TYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPP 1596
Score = 61.2 bits (147), Expect = 5e-09
Identities = 133/653 (20%), Positives = 241/653 (36%), Gaps = 57/653 (8%)
Query: 108 SSVGTVTTATAPNPVRNLRVEAQTNS-SIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTR 166
SS T P E++ +S S+++ W + P + + Y+ D A
Sbjct: 231 SSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSP----CNFSLIYSSDTLGAALC 286
Query: 167 STAHTNITVDG-----LEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRV----E 217
T + T G L+ G +Y F I S E R +P+ R E
Sbjct: 287 PTFRIDNTTYGCNLQDLQAGTIYNFR-------IISLDEERTVVLQTDPLPPARFGVSKE 339
Query: 218 AQTTSSISLSWEVPDGTDPQNSTYCVQCTGDG-----GRTETRNTTDTRVTVDGLGPGSL 272
T++S+ + W G + ++Y VQ + G +T+ T L GS
Sbjct: 340 KTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSK 396
Query: 273 YTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 332
Y ++ G S +T P+PV+++ + + N S+ ++W G + + +
Sbjct: 397 YNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLLISWSHGSG-NVERYRLML 454
Query: 333 EYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNL 392
G G T+ L PG LY +V G+ + R + TAP V NL
Sbjct: 455 MDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYR-WKLVRTAPMEVSNL 513
Query: 393 HMETQTN-SSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLY 451
+ + +S+ + W+ P G Y + + G + T + L PG LY
Sbjct: 514 KVTNDGSLTSLKVKWQRPPGNV-DSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLY 572
Query: 452 TFSVWAEKNGARGSRQNVSISTVPNAVTSL-SKQDWTNSTIALRWTAPQGPGQS--SYSY 508
+V + V T P+ V +L + + ++ + W+ P G + +
Sbjct: 573 QVTVSCVSGELSAQKMAVG-RTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLF 631
Query: 509 WVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEV 568
S V +T + ++ D T L G Y + V E ++ + T P V
Sbjct: 632 NDSVVLLNITVGKEETQYVMDDT--GLVPGRQYEVEVIVESGNLKN-SERCQGRTVPLAV 688
Query: 569 TDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNET 628
L+ + + S+ + W+ P ++ Y + A D ++++ +
Sbjct: 689 LQLRVKHANETSLSIMWQT---PVAEWEKYIISLA---------DRDLLLIHKSLSKDAK 736
Query: 629 WYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSC 688
+ L PG Y TV + D+ +S+ S+ T P VT + + W+
Sbjct: 737 EFTFTDLVPGRKYMATVTSISGDLKNSS-SVKGRTVPAQVTDLHVANQGMTSSLFTNWTQ 795
Query: 689 PQGGYEAFELEVGGQR---GSQDRSSCGEAVSVLGLGPARSYPATITTIWDGM 738
QG E +++ + + ++ SS S L Y +TT+ G+
Sbjct: 796 AQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI 848
Score = 59.3 bits (142), Expect = 2e-08
Identities = 93/391 (23%), Positives = 143/391 (36%), Gaps = 41/391 (10%)
Query: 45 SISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT----VDGLGPGSLYTCSVW 100
S+ +SW+ G+ + Y + + G RNT+ T + L PG Y +
Sbjct: 1229 SLIVSWQKAAGVAER---YDILLLTENGIL-LRNTSEPATTKQHKFEDLTPGKKYKIQIL 1284
Query: 101 VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
G+ S T P V +LR+ + ++ W +G + S Y +
Sbjct: 1285 TVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEG---ELSWYNIFLYNPD 1341
Query: 161 GRAGTRSTAHT---NITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLR-V 216
G R+ + + L G +Y + V +G S+ T V +LR
Sbjct: 1342 GNLQERAQVDPLVQSFSFQNLLQGRMYKMVI-VTHSGELSNESFIFGRTVPASVSHLRGS 1400
Query: 217 EAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVT---VDGLGPGSLY 273
TT S+ +W G G T+ N D +T GL PG Y
Sbjct: 1401 NRNTTDSLWFNWSPASGDFDFYELILYNPNG----TKKENWKDKDLTEWRFQGLVPGRKY 1456
Query: 274 TCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVE 333
V V G S+ S TAP+P ++ N+S+A+TW+ GP E
Sbjct: 1457 VLWV-VTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFE 1512
Query: 334 YTGDGGRAGTRSTAHTNIT-----VDRLEPGCLYVFSVWVGKNGINSSRETRN------A 382
A T + N V L PG Y F+V K S +T +
Sbjct: 1513 LQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSV 1569
Query: 383 TTAPNPVRNLHMETQTNSSIALCWEVPDGPY 413
T P+ ++NLH Q +++IA W PD +
Sbjct: 1570 RTKPDKIQNLHCRPQNSTAIACSWIPPDSDF 1600
Score = 43.1 bits (100), Expect = 0.001
Identities = 64/279 (22%), Positives = 107/279 (38%), Gaps = 35/279 (12%)
Query: 42 TTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT---VDGLGPGSLYTCS 98
TT S+ +W G + +++ + T+ N ++T GL PG Y
Sbjct: 1404 TTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLW 1459
Query: 99 VWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 158
V +++ V T + TAP+P + N+S+A+TW+ GP E
Sbjct: 1460 VVTHSGDLSNKV-TAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFELQW 1515
Query: 159 DGGRAGTRSTAHTNIT-----VDGLEPGCLYAFSMWVGKNGINSSRETRN------ATTA 207
A T + N V GL PG Y F++ K S +T + T
Sbjct: 1516 LPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSVRTK 1572
Query: 208 HNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQC----TGDGGRTETRNTTDTRVT 263
+ ++NL Q +++I+ SW PD Y ++C T + + + +
Sbjct: 1573 PDKIQNLHCRPQNSTAIACSWIPPDS---DFDGYSIECRKMDTQEVEFSRKLEKEKSLLN 1629
Query: 264 VDGLGPGSLYTCSVWVEKDGVNSSV---EIVTSATAPNP 299
+ L P Y S+ V+ G+ S V +T P P
Sbjct: 1630 IMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPP 1668
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 280 bits (717), Expect = 4e-75
Identities = 152/372 (40%), Positives = 217/372 (58%), Gaps = 24/372 (6%)
Query: 753 GVIAGAFVGILLFLILVGLLIFFLKRRNKKK-QQKPELR-----------DLVFSSPGD- 799
G I G G+ L +LV ++ + R+ +++P R L G+
Sbjct: 1618 GAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNR 1677
Query: 800 -----IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVL 854
I F H K + DSN + +Y++L VG +QS +A EN KNRY N+L
Sbjct: 1678 KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNIL 1737
Query: 855 PYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHT 914
PYD +RV L + ++P SDYINAS++PG +E+I TQGPLP T DFW++VWEQ H
Sbjct: 1738 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 1797
Query: 915 LVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE-QKT 973
+VM+T C+E GRVKC+HYWP D +G L + ++ E V+ WT+RE + E+
Sbjct: 1798 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 1857
Query: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
+R FHY WPDHGVP + +L+ F R +R +++++ GP +VHCSAGVGRTGT IAL
Sbjct: 1858 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 1917
Query: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVP 1093
D +L+QL S+ + + V +R R MVQTE QYV+LHQC+ R + ++ + +E+E P
Sbjct: 1918 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV-RDVLRARKLRSEQENP 1976
Query: 1094 YEDVENLIYENV 1105
IYENV
Sbjct: 1977 LFP----IYENV 1984
Score = 99.0 bits (245), Expect = 2e-20
Identities = 169/741 (22%), Positives = 282/741 (38%), Gaps = 83/741 (11%)
Query: 28 PAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG-----GTTETRNTTAT 82
P P ++ E T++S+ + W G + ++Y VQ + G +T+
Sbjct: 110 PLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQESTSWN 166
Query: 83 NVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVP 142
T L GS Y ++ G S +T P+PV+++ + + N S+ ++W
Sbjct: 167 EYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLLISWSHG 225
Query: 143 DGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETR 202
G + + + G G T+ GL PG LY ++ G+ + R +
Sbjct: 226 SG-NVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYR-WK 283
Query: 203 NATTAHNPVRNLRVEAQ-TTSSISLSWEVPDG-TDPQNSTYCVQCTGDGGRTETRNTTDT 260
TA V NL+V + +S+ + W+ P G D N T + T R T+T
Sbjct: 284 LVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITET 343
Query: 261 RVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNS---SIALTW 317
L PG LY +V G S+ ++ T P+ V NL EA N S+ ++W
Sbjct: 344 H--FKELVPGRLYQVTVSC-VSGELSAQKMAVGRTFPDKVANL--EANNNGRMRSLVVSW 398
Query: 318 EVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDR-----------LEPGCLYVFSV 366
P G Q Y + D S NITV + L PG Y V
Sbjct: 399 SPPAGDWEQ---YRILLFND-------SVVLLNITVGKEETQYVMDDTGLVPGRQYEVEV 448
Query: 367 WVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGD 426
V + +S E T P V L ++ +S+++ W+ P W +Y
Sbjct: 449 IVESGNLKNS-ERCQGRTVPLAVLQLRVKHANETSLSIMWQTP-------VAEWEKYIIS 500
Query: 427 GGGTE------TRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTS 480
+ + + T L PG Y +V + + S +V TVP VT
Sbjct: 501 LADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNS-SSVKGRTVPAQVTD 559
Query: 481 L--SKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTD-ITLKELEA 537
L + Q T S++ WT QG + Y V + E + +S T + L++
Sbjct: 560 LHVANQGMT-SSLFTNWTQAQGDVE---FYQVLLIHENVVIKNESISSETSRYSFHSLKS 615
Query: 538 GSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVM--LWWKAPGDPHSQL 595
GSLY + V + + T P+ V+ + +N + W APGD +
Sbjct: 616 GSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDN-- 673
Query: 596 YVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASS 655
Y V + G+ Q+ + ++ R +L PG LY T+ +
Sbjct: 674 --YEVTLS-----HDGKVVQSLVIAKSVRE----CSFSSLTPGRLYTVTITTRSGKYENH 722
Query: 656 TQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEA 715
+ S T PD V S +++ + + W G ++ +E+ + + S ++
Sbjct: 723 SFSQ-ERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKS 781
Query: 716 VS---VLGLGPARSYPATITT 733
+ + L P R Y T+TT
Sbjct: 782 ENECVFVQLVPGRLYSVTVTT 802
Score = 86.7 bits (213), Expect = 1e-16
Identities = 166/739 (22%), Positives = 270/739 (36%), Gaps = 91/739 (12%)
Query: 31 NPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETR--NTTATNVTVDG 88
N GRN +S+SW + G NY V + DG ++ + +
Sbjct: 653 NSGRN--------DYLSVSWLLAPG---DVDNYEVTLSHDGKVVQSLVIAKSVRECSFSS 701
Query: 89 LGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSS-IALTWEVPDGPDP 147
L PG LYT ++ + G + T P+ V+ + V S + ++W G
Sbjct: 702 LTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFD 760
Query: 148 QNSTYGVEYTGDGGRAGTRST--AHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNAT 205
Y V T+S + L PG LY+ ++ K+G + E N
Sbjct: 761 H---YEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTT-KSGQYEANEQGNGR 816
Query: 206 TAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTE-----TRNTTDT 260
T PV++L + ++T + ++W +G Q Y +Q + + T+
Sbjct: 817 TIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQ---YEIQLLFNDMKVFPPFHLVNTATEY 873
Query: 261 RVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQ-TNSSIALTWEV 319
R T L PG Y V V S + T P+ V+N+ + S+ + W
Sbjct: 874 RFT--SLTPGRQYKILVLTISGDVQQSA-FIEGFTVPSAVKNIHISPNGATDSLTVNW-T 929
Query: 320 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRET 379
P G D + T + T T RLE G Y + +G ++
Sbjct: 930 PGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI-ASVSGSLKNQIN 988
Query: 380 RNATTAPNPVRNLHMETQTNS-SIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETRNTTN 437
T P V+ + + +S S+ + W+ G + D E G RNT+
Sbjct: 989 VVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE-----NGILLRNTSE 1043
Query: 438 TSVTA----ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIAL 493
+ T E L PG Y + G TVP AVT L + + ++
Sbjct: 1044 PATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSF 1103
Query: 494 RWTAPQGPGQSSYSYWV-----SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAE 548
RWTA +G S Y+ ++ + DP QS S + L G +Y + +
Sbjct: 1104 RWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFS-----FQNLLQGRMYKMVIVTH 1157
Query: 549 RNEVRGYNSTLTAATAPNEVTDLQ--NETQTKNSVMLWWKAPGD-PHSQLYVYWVQWASK 605
E+ S + T P V+ L+ N T + W A GD +L +Y K
Sbjct: 1158 SGELSN-ESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKK 1216
Query: 606 GHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVAS--STQSLCAST 663
NW ++ + T ++ + L PG Y V D+++ + +S A +
Sbjct: 1217 ----------ENWKDK----DLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPS 1262
Query: 664 YPDTVTITSCVSTSAGYGVNLIWSCPQG--GYEAFELE------VGGQRGSQDRSSCGEA 715
P ++ +TS + + W P Y FEL+ + +R S G
Sbjct: 1263 PPSLMSFADIANTS----LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI 1318
Query: 716 VSVLGLGPARSYPATITTI 734
V GL P RSY + T+
Sbjct: 1319 --VYGLRPGRSYQFNVKTV 1335
Score = 74.7 bits (182), Expect = 5e-13
Identities = 104/467 (22%), Positives = 184/467 (39%), Gaps = 45/467 (9%)
Query: 291 VTSATAPNPVRNLTV--EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG-----GRAGT 343
V T P P V E T++S+ + W G + ++Y V+ + G
Sbjct: 104 VVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQ 160
Query: 344 RSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIA 403
ST+ T L G Y ++ G S N +T P+PV+++ + T+ N S+
Sbjct: 161 ESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLL 219
Query: 404 LCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNTTNTSVTAERLEPGTLYTFSVWAEK 459
+ W G + Y + G GG ++ TS L PG LY +V E
Sbjct: 220 ISWSHGSGNVER---YRLMLMDKGILVHGGVVDKHA--TSYAFHGLTPGYLYNLTVMTEA 274
Query: 460 NGARGSRQNVSISTVPNAVTSLS-KQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMT 518
G + R + + T P V++L D + +++ ++W P G SY+ +S + +
Sbjct: 275 AGLQNYRWKL-VRTAPMEVSNLKVTNDGSLTSLKVKWQRPPG-NVDSYNITLSH-KGTIK 331
Query: 519 DPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQ-NETQT 577
+ R + T+ KEL G LY +TV E+ + T P++V +L+ N
Sbjct: 332 ESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAV-GRTFPDKVANLEANNNGR 390
Query: 578 KNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE--AL 635
S+++ W P Q + + +N T ET Y ++ L
Sbjct: 391 MRSLVVSWSPPAGDWEQYRILLF------------NDSVVLLNITVGKEETQYVMDDTGL 438
Query: 636 EPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEA 695
PG Y V E ++ +S + C + V + ++++W P +E
Sbjct: 439 VPGRQYEVEVIVESGNLKNSER--CQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEK 496
Query: 696 FELEVGGQ---RGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMK 739
+ + + + + S + + L P R Y AT+T+I +K
Sbjct: 497 YIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLK 543
Score = 70.5 bits (171), Expect = 9e-12
Identities = 139/709 (19%), Positives = 268/709 (37%), Gaps = 44/709 (6%)
Query: 45 SISLSWEVPDGLDSQNSNYWVQCTGDG----GTTETRNTTATNVTVDGLGPGSLYTCSVW 100
S+ +SW P G Q Y + D T + T + GL PG Y V
Sbjct: 393 SLVVSWSPPAGDWEQ---YRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVI 449
Query: 101 VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
VE + +S T P V LRV+ +S+++ W+ P + Y +
Sbjct: 450 VESGNLKNSE-RCQGRTVPLAVLQLRVKHANETSLSIMWQTPVA---EWEKYIISLADRD 505
Query: 161 GRAGTRSTAHT--NITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEA 218
+S + T L PG Y ++ + +S + T V +L V
Sbjct: 506 LLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQ-VTDLHVAN 564
Query: 219 Q-TTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSV 277
Q TSS+ +W G D + + + E+ ++ +R + L GSLY+ V
Sbjct: 565 QGMTSSLFTNWTQAQG-DVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVV 623
Query: 278 WVEKDGVNSSVEIVTSATAPNPVRNLTV-EAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 336
G++S +V T P+ V +TV + N ++++W + G D N + + G
Sbjct: 624 TTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPG-DVDNYEVTLSHDG 682
Query: 337 DGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMET 396
++ + + + L PG LY ++ ++G + T P+ V+ + +
Sbjct: 683 KVVQSLVIAKSVRECSFSSLTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSN 741
Query: 397 QTNSS-IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSV 455
S + + W G + Y ++ + T++ + +L PG LY+ +V
Sbjct: 742 SARSDYLRVSWVHATGDF-DHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTV 800
Query: 456 WAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVRE 515
K+G + + + T+P V L+ ++ + + + W+ G Y + +
Sbjct: 801 -TTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANG-DVDQYEIQLLFNDM 858
Query: 516 GMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNET 575
+ P + T+ L G Y + V +V+ ++ + T P+ V ++
Sbjct: 859 KVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQ-QSAFIEGFTVPSAVKNIHISP 917
Query: 576 Q--TKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE 633
T + + W GD S Y V ++ H ++ +QT + +
Sbjct: 918 NGATDSLTVNWTPGGGDVDS----YTV--SAFRHSQKVD-------SQTIPKHVFEHTFH 964
Query: 634 ALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGY 693
LE G Y + A + + ++ T P +V + + Y + + W G
Sbjct: 965 RLEAGEQYQIMI-ASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVA 1023
Query: 694 EAFELEVGGQRGSQDRSSCGEAVS----VLGLGPARSYPATITTIWDGM 738
E +++ + + G R++ A + L P + Y I T+ G+
Sbjct: 1024 ERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGL 1072
Score = 65.5 bits (158), Expect = 3e-10
Identities = 114/577 (19%), Positives = 204/577 (35%), Gaps = 35/577 (6%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTET---RNTTATNVTV 86
P P ++LT+ ++T + ++W G + Y +Q + TAT
Sbjct: 819 PEPVKDLTLRNRSTEDLHVTW---SGANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRF 875
Query: 87 DGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQ-TNSSIALTWEVPDGP 145
L PG Y V V S + T P+ V+N+ + S+ + W P G
Sbjct: 876 TSLTPGRQYKILVLTISGDVQQS-AFIEGFTVPSAVKNIHISPNGATDSLTVNW-TPGGG 933
Query: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNAT 205
D + T + T T LE G Y + + + T
Sbjct: 934 DVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRT 993
Query: 206 TAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVD 265
+ + A ++ S+ +SW+ G + + G R + T + +
Sbjct: 994 VPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFE 1053
Query: 266 GLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDP 325
L PG Y + G+ S T P V +L + + ++ W +G
Sbjct: 1054 DLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEG--- 1110
Query: 326 QNSTYGVEYTGDGGRAGTRSTAH---TNITVDRLEPGCLYVFSVWVGKNGINSSRETRNA 382
+ S Y + G R+ + + L G +Y V V +G S+
Sbjct: 1111 ELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKM-VIVTHSGELSNESFIFG 1169
Query: 383 TTAPNPVRNLH-METQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVT 441
T P V +L T S+ W G D+ ++ + GT+ N + +T
Sbjct: 1170 RTVPASVSHLRGSNRNTTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLT 1225
Query: 442 AER---LEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAP 498
R L PG Y V +G ++ T P+ + +S D N+++A+ W P
Sbjct: 1226 EWRFQGLVPGRKYVLWV-VTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWKGP 1284
Query: 499 QGPGQSSYS-YWVSWV-REGMT--DPRTQSTSGTDITLKELEAGSLYHLTV-WAERNEVR 553
P + Y+ + + W+ R+ +T +P S I + L G Y V + +
Sbjct: 1285 --PDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI-VYGLRPGRSYQFNVKTVSGDSWK 1341
Query: 554 GYNSTL--TAATAPNEVTDLQNETQTKNSVMLWWKAP 588
Y+ + + T P+++ +L Q ++ W P
Sbjct: 1342 TYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPP 1378
Score = 60.8 bits (146), Expect = 7e-09
Identities = 127/629 (20%), Positives = 234/629 (37%), Gaps = 56/629 (8%)
Query: 131 TNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDG-----LEPGCLYA 185
++ S+++ W + P + + Y+ D A T + T G L+ G +Y
Sbjct: 37 SSHSVSIQWRILGSP----CNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYN 92
Query: 186 FSMWVGKNGINSSRETRNATTAHNPVRNLRV----EAQTTSSISLSWEVPDGTDPQNSTY 241
F I S E R +P+ R E T++S+ + W G + ++Y
Sbjct: 93 FR-------IISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSY 142
Query: 242 CVQCTGDG-----GRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATA 296
VQ + G +T+ T L GS Y ++ G S +T
Sbjct: 143 EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTV 202
Query: 297 PNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRL 356
P+PV+++ + + N S+ ++W G + + + G G T+ L
Sbjct: 203 PSPVKDIGISTKAN-SLLISWSHGSG-NVERYRLMLMDKGILVHGGVVDKHATSYAFHGL 260
Query: 357 EPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTN-SSIALCWEVPDGPYPQ 415
PG LY +V G+ + R + TAP V NL + + +S+ + W+ P G
Sbjct: 261 TPGYLYNLTVMTEAAGLQNYR-WKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNV-D 318
Query: 416 DYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVP 475
Y + + G + T + L PG LY +V + V T P
Sbjct: 319 SYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVG-RTFP 377
Query: 476 NAVTSL-SKQDWTNSTIALRWTAPQGPGQS--SYSYWVSWVREGMTDPRTQSTSGTDITL 532
+ V +L + + ++ + W+ P G + + S V +T + ++ D T
Sbjct: 378 DKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDT- 436
Query: 533 KELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPH 592
L G Y + V E ++ + T P V L+ + + S+ + W+ P
Sbjct: 437 -GLVPGRQYEVEVIVESGNLKN-SERCQGRTVPLAVLQLRVKHANETSLSIMWQT---PV 491
Query: 593 SQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDV 652
++ Y + A D ++++ + + L PG Y TV + D+
Sbjct: 492 AEWEKYIISLA---------DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDL 542
Query: 653 ASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQR---GSQDR 709
+S+ S+ T P VT + + W+ QG E +++ + + ++
Sbjct: 543 KNSS-SVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESI 601
Query: 710 SSCGEAVSVLGLGPARSYPATITTIWDGM 738
SS S L Y +TT+ G+
Sbjct: 602 SSETSRYSFHSLKSGSLYSVVVTTVSGGI 630
Score = 59.3 bits (142), Expect = 2e-08
Identities = 93/391 (23%), Positives = 143/391 (36%), Gaps = 41/391 (10%)
Query: 45 SISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT----VDGLGPGSLYTCSVW 100
S+ +SW+ G+ + Y + + G RNT+ T + L PG Y +
Sbjct: 1011 SLIVSWQKAAGVAER---YDILLLTENGIL-LRNTSEPATTKQHKFEDLTPGKKYKIQIL 1066
Query: 101 VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
G+ S T P V +LR+ + ++ W +G + S Y +
Sbjct: 1067 TVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEG---ELSWYNIFLYNPD 1123
Query: 161 GRAGTRSTAHT---NITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLR-V 216
G R+ + + L G +Y + V +G S+ T V +LR
Sbjct: 1124 GNLQERAQVDPLVQSFSFQNLLQGRMYKMVI-VTHSGELSNESFIFGRTVPASVSHLRGS 1182
Query: 217 EAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVT---VDGLGPGSLY 273
TT S+ +W G G T+ N D +T GL PG Y
Sbjct: 1183 NRNTTDSLWFNWSPASGDFDFYELILYNPNG----TKKENWKDKDLTEWRFQGLVPGRKY 1238
Query: 274 TCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVE 333
V V G S+ S TAP+P ++ N+S+A+TW+ GP E
Sbjct: 1239 VLWV-VTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFE 1294
Query: 334 YTGDGGRAGTRSTAHTNIT-----VDRLEPGCLYVFSVWVGKNGINSSRETRN------A 382
A T + N V L PG Y F+V K S +T +
Sbjct: 1295 LQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSV 1351
Query: 383 TTAPNPVRNLHMETQTNSSIALCWEVPDGPY 413
T P+ ++NLH Q +++IA W PD +
Sbjct: 1352 RTKPDKIQNLHCRPQNSTAIACSWIPPDSDF 1382
Score = 43.1 bits (100), Expect = 0.001
Identities = 64/279 (22%), Positives = 107/279 (38%), Gaps = 35/279 (12%)
Query: 42 TTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT---VDGLGPGSLYTCS 98
TT S+ +W G + +++ + T+ N ++T GL PG Y
Sbjct: 1186 TTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLW 1241
Query: 99 VWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 158
V +++ V T + TAP+P + N+S+A+TW+ GP E
Sbjct: 1242 VVTHSGDLSNKV-TAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFELQW 1297
Query: 159 DGGRAGTRSTAHTNIT-----VDGLEPGCLYAFSMWVGKNGINSSRETRN------ATTA 207
A T + N V GL PG Y F++ K S +T + T
Sbjct: 1298 LPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSVRTK 1354
Query: 208 HNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQC----TGDGGRTETRNTTDTRVT 263
+ ++NL Q +++I+ SW PD Y ++C T + + + +
Sbjct: 1355 PDKIQNLHCRPQNSTAIACSWIPPDS---DFDGYSIECRKMDTQEVEFSRKLEKEKSLLN 1411
Query: 264 VDGLGPGSLYTCSVWVEKDGVNSSV---EIVTSATAPNP 299
+ L P Y S+ V+ G+ S V +T P P
Sbjct: 1412 IMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPP 1450
>gi|4506323 receptor-type protein tyrosine phosphatase O isoform b
precursor [Homo sapiens]
Length = 1188
Score = 279 bits (714), Expect = 9e-75
Identities = 214/715 (29%), Positives = 332/715 (46%), Gaps = 86/715 (12%)
Query: 443 ERLEPGTLYTFSVWAEKNGARGSRQN-VSISTVPNAVTSLSKQDWTNSTIALRWTAPQGP 501
E L PG Y ++ K G + V+ + VP + L + + L WT P
Sbjct: 497 ENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLG 556
Query: 502 GQSSY-------------SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTV--- 545
Y S W ++ T T S + + L Y+ V
Sbjct: 557 VFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTAS-----VRIANLLPAWYYNFRVTMV 611
Query: 546 -WAERNEVRGYNSTLTAATAP--NEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 602
W + +ST++ TAP E+T ++ + + + W D + + W
Sbjct: 612 TWGDPELSCCDSSTISFITAPVAPEITSVE---YFNSLLYISWTYGDDTTDLSHSRMLHW 668
Query: 603 ASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWA--ERNDVASSTQSL- 659
++ + S T + +L PG +YN +V A ER S + +
Sbjct: 669 MVVAEGKKKI--------KKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK 720
Query: 660 CASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVL 719
P ++ + TS V L+W +G + FE+ Q GS ++ E V+V
Sbjct: 721 LEPAPPKSLFAVNKTQTS----VTLLW-VEEGVADFFEVFCQ-QVGSSQKTKLQEPVAVS 774
Query: 720 G-------LGPARSYPATITTI-WDGMKV---VSHSVVCHTESAGVIAGAFVGILLFLIL 768
L PA +Y ++T+ D V ++ S + + V+ + + IL L++
Sbjct: 775 SHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLI 834
Query: 769 VGLLIFFLKRRNKKKQQKPELRDLVFSS------PGDIP------------------AED 804
LL+ + R K Q E F + G +P +D
Sbjct: 835 GLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDD 894
Query: 805 FADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLK 864
F +++ +DS+ F+ ++++L L+G A N KNRY N+LPYD+SRV L
Sbjct: 895 FDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLV 954
Query: 865 PIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEA 924
++EE G+DYINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT C E
Sbjct: 955 SMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK 1014
Query: 925 GRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAW 984
RVKC+HYWP +P +G + V ++ EE ++W R + +E + V F+Y AW
Sbjct: 1015 RRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHFNYTAW 1072
Query: 985 PDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQS 1042
PDHGVP ++ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL+ ++
Sbjct: 1073 PDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRD 1130
Query: 1043 EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 1097
+ V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 1131 HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 1185
Score = 37.4 bits (85), Expect = 0.080
Identities = 50/229 (21%), Positives = 91/229 (39%), Gaps = 25/229 (10%)
Query: 261 RVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVP 320
RVT+ G L C +S++ +T+ AP +T NS + ++W
Sbjct: 607 RVTMVTWGDPELSCCD--------SSTISFITAPVAPE----ITSVEYFNSLLYISWTYG 654
Query: 321 DGPDPQNSTYGVEY--TGDGGRAGTRSTAHTNIT-VDRLEPGCLYVFSVWVGKNGINSSR 377
D + + + + +G + +S +T + L PG +Y SV +++
Sbjct: 655 DDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTS 714
Query: 378 ETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTN 437
R P P ++L +T +S+ L W V +G + + + G T+ +
Sbjct: 715 MLRLVKLEPAPPKSLFAVNKTQTSVTLLW-VEEG-VADFFEVFCQQVGSSQKTKLQEPVA 772
Query: 438 TS---VTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTV-----PNAV 478
S VT L P T Y SV + + + +++ST+ PN V
Sbjct: 773 VSSHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVV 821
Score = 32.0 bits (71), Expect = 3.4
Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 8/98 (8%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN---VTV 86
P P ++L +T +S++L W V +G+ + + Q G T+ + A + VT+
Sbjct: 723 PAPPKSLFAVNKTQTSVTLLW-VEEGV-ADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI 780
Query: 87 DGLGPGSLYTCSVWV---EKDGVNSSVGTVTTATAPNP 121
L P + Y CSV + V + + T T NP
Sbjct: 781 SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNP 818
>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 268 bits (686), Expect = 2e-71
Identities = 137/329 (41%), Positives = 201/329 (61%), Gaps = 13/329 (3%)
Query: 771 LLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLV 830
LL F++ +K +K +L + + +DF +++ +DS+ F+ ++++L L+
Sbjct: 85 LLAFYINPWSKNGLKKRKLTN-------PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLI 137
Query: 831 GHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFI 890
G A N KNRY N+LPYD+SRV L ++EE G+DYINA+++PG SPQE+I
Sbjct: 138 GLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYI 197
Query: 891 ATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLV 950
ATQGPLP+T DFW++V +Q+S +VMLT C E RVKC+HYWP +P +G + V ++
Sbjct: 198 ATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMI 257
Query: 951 GEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVP--SSPDTLLAFWRMLRQWLD 1008
EE ++W R + +E + V F+Y AWPDHGVP ++ +++L F M+RQ
Sbjct: 258 SEEEQDDWACRHFRINYADEMQ--DVMHFNYTAWPDHGVPTANAAESILQFVHMVRQ--Q 313
Query: 1009 QTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQ 1068
T GP I+HCSAGVGRTGT IALD LL+ ++ + V +MR R MVQTE Q
Sbjct: 314 ATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQ 373
Query: 1069 YVFLHQCILRFLQQSAQAPAEKEVPYEDV 1097
Y+F+HQC+ + Q +V YE+V
Sbjct: 374 YIFIHQCVQLMWMKKKQQFCISDVIYENV 402
>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 268 bits (686), Expect = 2e-71
Identities = 137/329 (41%), Positives = 201/329 (61%), Gaps = 13/329 (3%)
Query: 771 LLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLV 830
LL F++ +K +K +L + + +DF +++ +DS+ F+ ++++L L+
Sbjct: 85 LLAFYINPWSKNGLKKRKLTN-------PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLI 137
Query: 831 GHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFI 890
G A N KNRY N+LPYD+SRV L ++EE G+DYINA+++PG SPQE+I
Sbjct: 138 GLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYI 197
Query: 891 ATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLV 950
ATQGPLP+T DFW++V +Q+S +VMLT C E RVKC+HYWP +P +G + V ++
Sbjct: 198 ATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMI 257
Query: 951 GEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVP--SSPDTLLAFWRMLRQWLD 1008
EE ++W R + +E + V F+Y AWPDHGVP ++ +++L F M+RQ
Sbjct: 258 SEEEQDDWACRHFRINYADEMQ--DVMHFNYTAWPDHGVPTANAAESILQFVHMVRQ--Q 313
Query: 1009 QTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQ 1068
T GP I+HCSAGVGRTGT IALD LL+ ++ + V +MR R MVQTE Q
Sbjct: 314 ATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQ 373
Query: 1069 YVFLHQCILRFLQQSAQAPAEKEVPYEDV 1097
Y+F+HQC+ + Q +V YE+V
Sbjct: 374 YIFIHQCVQLMWMKKKQQFCISDVIYENV 402
>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 266 bits (681), Expect = 6e-71
Identities = 131/300 (43%), Positives = 189/300 (63%), Gaps = 6/300 (2%)
Query: 800 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859
+ +DF +++ +DS+ F+ ++++L L+G A N KNRY N+LPYD+S
Sbjct: 79 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
Query: 860 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 919
RV L ++EE G+DYINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT
Sbjct: 139 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
Query: 920 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 979
C E RVKC+HYWP +P +G + V ++ EE ++W R + +E + V F
Sbjct: 199 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHF 256
Query: 980 HYQAWPDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLL 1037
+Y AWPDHGVP ++ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL
Sbjct: 257 NYTAWPDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLL 314
Query: 1038 RQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 1097
+ ++ + V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 374
>gi|13677216 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 266 bits (681), Expect = 6e-71
Identities = 131/300 (43%), Positives = 189/300 (63%), Gaps = 6/300 (2%)
Query: 800 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859
+ +DF +++ +DS+ F+ ++++L L+G A N KNRY N+LPYD+S
Sbjct: 79 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
Query: 860 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 919
RV L ++EE G+DYINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT
Sbjct: 139 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
Query: 920 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 979
C E RVKC+HYWP +P +G + V ++ EE ++W R + +E + V F
Sbjct: 199 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHF 256
Query: 980 HYQAWPDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLL 1037
+Y AWPDHGVP ++ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL
Sbjct: 257 NYTAWPDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLL 314
Query: 1038 RQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 1097
+ ++ + V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 374
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 239 bits (609), Expect = 1e-62
Identities = 129/346 (37%), Positives = 193/346 (55%), Gaps = 27/346 (7%)
Query: 755 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPE------------------LRDLVFSS 796
+ G + ++L +++V ++ F ++R K E +R L + +
Sbjct: 1264 VTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQT 1323
Query: 797 PG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYR 851
PG IP D AD++ + + + F+ +Y+ + G + ++ N KNRY
Sbjct: 1324 PGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID-PGQQFTWENSNLEVNKPKNRYA 1382
Query: 852 NVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQ 911
NV+ YD SRV L I PGSDYINA+++ G +IATQGPLP+T+GDFWR+VWEQ+
Sbjct: 1383 NVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQR 1442
Query: 912 SHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQ 971
+ T+VM+T E RVKC+ YWP T G ++VTL+ + +TVR L +
Sbjct: 1443 TATVVMMTRLEEKSRVKCDQYWPARGTE-TCGLIQVTLLDTVELATYTVRTFALHKSGSS 1501
Query: 972 KTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLI 1031
+ +RQF + AWPDHGVP P +LAF R ++ ++ GP +VHCSAGVGRTG I
Sbjct: 1502 EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC--NPLDAGPMVVHCSAGVGRTGCFI 1559
Query: 1032 ALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
+D +L +++ E + + V MR R MVQTE QYVF+H+ +L
Sbjct: 1560 VIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL 1605
Score = 196 bits (498), Expect = 1e-49
Identities = 104/287 (36%), Positives = 164/287 (57%), Gaps = 6/287 (2%)
Query: 799 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 853
++PA + H++K + +S +++ L S H+ + A+ N KNR N+
Sbjct: 1614 EVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNI 1673
Query: 854 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 913
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL ++ DFWR++WE S
Sbjct: 1674 MPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNST 1733
Query: 914 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 973
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1734 IIVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1792
Query: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
++RQF + WP+ GVP + + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1793 RTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITL 1852
Query: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
++L +++ EG++ F V+ +R RP MVQTE QY ++ L +L
Sbjct: 1853 SIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL 1899
Score = 83.2 bits (204), Expect = 1e-15
Identities = 145/662 (21%), Positives = 252/662 (38%), Gaps = 85/662 (12%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + G+ + VT P P +L V T +S+ LTW+ G + YG+
Sbjct: 296 YTC-VAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGI 352
Query: 155 EYTGDGGRAGTR---STAHTNITVDGLEPGCLYAFSMW----VGKNGINSSRETRNATTA 207
+Y G + A T ++ GL P YAF + +G+ + + R A
Sbjct: 353 QYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA 412
Query: 208 -HNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTET---RNTTDTRV- 262
+P R ++ + S++ + WE P+ + Y V T D R ++ TD +
Sbjct: 413 PSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLL 472
Query: 263 -TVDGLGPGSLYTCSV---WVEKDGVNS-SVEIVTSATAPNPVRNLTVEAQTNSSIALTW 317
TV L PG Y+ V DG S ++++ T P + E ++++ I L+W
Sbjct: 473 TTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSW 532
Query: 318 EVPDGPDPQNSTYGVEY---TGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVW----VGK 370
+P P + Y + Y + + ++ T++ L+P LY F + +G
Sbjct: 533 LLP--PQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGV 590
Query: 371 NGINSSRETRNATTAPN-PVRNLHMETQTNSSIALCWEVP--DGPYPQDYTYWVEYTGDG 427
+ E R A + P+ P + + + ++++ + W P D Y V Y
Sbjct: 591 GVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVD 650
Query: 428 GGTETRNTT------NTSVTAERLEPGTLYTFSVWAEKNGARGSRQN-VSIST---VPNA 477
G R+ ++S LE T Y V A + G + V + T VP+
Sbjct: 651 GEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSG 710
Query: 478 VTSLSKQDWTNST-IALRWTAPQGPGQSSY--SYWVSWVREGMTDP-------------- 520
+ + NST + + W P Q Y V++VR +P
Sbjct: 711 PPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEA 770
Query: 521 --RTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAATAPNEVTDLQNE 574
R + + + T+ L + Y +TV A + G S T P T +
Sbjct: 771 QWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPT-MMIS 829
Query: 575 TQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEA 634
T N+ +L W P + +L Y +Q+ R + + N ++ ++ + V
Sbjct: 830 TTAMNTALLQWHPPKELPGELLGYRLQYC------RADEARPNTID--FGKDDQHFTVTG 881
Query: 635 LEPGTLYNFTVWA-------ERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWS 687
L GT Y F + A E + T S +P + +T +++ L W
Sbjct: 882 LHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTST----TELAWD 937
Query: 688 CP 689
P
Sbjct: 938 PP 939
Score = 78.6 bits (192), Expect = 3e-14
Identities = 165/773 (21%), Positives = 284/773 (36%), Gaps = 107/773 (13%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTG---DGGTTETRNTTATNVTV 86
P P +L V T +S++L+W+ G + Y +Q +G E T ++
Sbjct: 319 PKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSI 376
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAP-NPVRNLRVEAQTNSSIALTWEV 141
GL P S Y V + + + +V T AP +P R ++ + S++ + WE
Sbjct: 377 GGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP 436
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHTN-----ITVDGLEPGCLYAFSMW----VGK 192
P+ P+ Y V YT D R H TV L PG Y+ + VG
Sbjct: 437 PEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGD 496
Query: 193 NGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRT 252
+ + + + + + E ++ + I LSW +P PQ +
Sbjct: 497 GPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLP----PQERIIMYELVYWAAED 552
Query: 253 ETRN---TTD--TRVTVDGLGPGSLYTCSVWVEKD-GV---NSSVEIVTSATAPN-PVRN 302
E + T D + T++ L P +LY + D GV ++E T+ + P+ P +
Sbjct: 553 EDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQK 612
Query: 303 LTVEAQTNSSIALTWEVPDGPDPQN---STYGVEYTGDGGRAGTR------STAHTNITV 353
+ + ++++ ++W VP D +N + Y V Y G R S H++ +
Sbjct: 613 VMCVSMGSTTVRVSW-VPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDL 671
Query: 354 DRLEPGCLYVFSVW------VGKNGINSSRETRNATTAPN-PVRNLHMETQTNSSIALCW 406
LE Y VW VG +S R P+ P R + +E ++++ + W
Sbjct: 672 VGLEKWTEY--RVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYW 729
Query: 407 E--VPDGPYPQDYTYWVEY----TGDGGGT-------------ETRNTTNTSVTAERLEP 447
+ VP + Q Y V Y G+ G + + T L P
Sbjct: 730 KLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTP 789
Query: 448 GTLYTFSVWAEKNGARGSRQNVSISTVPNAV---TSLSKQDWTNSTIALRWTAPQGPGQS 504
T Y+ +V A G+R I T AV ++ +T L+W P+
Sbjct: 790 ETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGE 849
Query: 505 SYSYWVSWVREGMTDPRTQSTSGTD--ITLKELEAGSLYHLTVWAERNEVRGYNSTLTAA 562
Y + + R P T D T+ L G+ Y + A+ G
Sbjct: 850 LLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIR 909
Query: 563 TAPNEV-----TDLQNETQTKNSVMLWWKAP--GDPHSQLYVYWVQWASKGHPRRGQDPQ 615
T P ++ +L T ++ L W P + + ++ Y V + + Q
Sbjct: 910 T-PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQ--- 965
Query: 616 ANWVNQTSRTNETWYKVEALEPGTLYNFTV--WAERND--VASSTQSL---CASTYPDTV 668
+ T +T + + L+P T Y+ V W + ++ S QS +
Sbjct: 966 -------NITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNF 1018
Query: 669 TITSCVSTSAGYGVNLIWSCPQGGYEA--FELEVGGQRGSQDRSSCGEAVSVL 719
+ + + TS V L W P A F++ GQ D S + ++ L
Sbjct: 1019 RVAAAMKTS----VLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADL 1067
Score = 65.5 bits (158), Expect = 3e-10
Identities = 114/504 (22%), Positives = 186/504 (36%), Gaps = 56/504 (11%)
Query: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN---SNYWVQCTGDGGTTETRNT 79
T P+ P + + V +T+ + +SW VP DS+N + Y V G R+
Sbjct: 601 TAQSTPSAPPQKVMCVSMGSTT-VRVSW-VPPPADSRNGVITQYSVAYEAVDGEDRGRHV 658
Query: 80 ----TATNVTVDGLGPGSLYTCSVWVEKD-----GVNSSVGTVTTA--TAPNPVRNLRVE 128
+ + + D +G VWV G SS V T P R + VE
Sbjct: 659 VDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVE 718
Query: 129 AQTNSSIALTWEVPDGPDPQNSTYGVEYT----GDGGRAGT---------------RSTA 169
++++ + W++P G + T +G G +
Sbjct: 719 PLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESE 778
Query: 170 HTNITVDGLEPGCLYAFSM--WVGKNGINSSRETRNATTAHNPVR-NLRVEAQTTSSISL 226
T+ GL P Y+ ++ + K S+ TT P R + + ++ L
Sbjct: 779 DYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALL 838
Query: 227 SWEVPDGTDPQNSTYCVQ-CTGDGGRTETRN--TTDTRVTVDGLGPGSLYTCSVWVEKD- 282
W P + Y +Q C D R T + D TV GL G+ Y + +
Sbjct: 839 QWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRA 898
Query: 283 --GVNSSVEIVTSATAPNPV-RNLTVEAQTNSSIALTWEVPDGPDPQNS--TYGVEYTGD 337
G EI T P+ +NL V T S+ L W+ P + +Y V +
Sbjct: 899 GLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDI 958
Query: 338 GGRAGTRS-TAHTNITVDRLEPGCLYVFSV--WVGKNG--INSSRETRNATTAPNPVRNL 392
+ ++ T T T+ L+P Y V W K ++ S ++R +N
Sbjct: 959 NSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNF 1018
Query: 393 HMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYT 452
+ +S+ L WEVPD Y + + Y G E + + A+ L+P T Y+
Sbjct: 1019 RVAAAMKTSVLLSWEVPDS-YKSAVPFKILYNGQ--SVEVDGHSMRKLIAD-LQPNTEYS 1074
Query: 453 FSVWAEKNGARGSRQNVSISTVPN 476
F + + A G + VSI T P+
Sbjct: 1075 FVLMNRGSSAGGLQHLVSIRTAPD 1098
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 239 bits (609), Expect = 1e-62
Identities = 129/346 (37%), Positives = 193/346 (55%), Gaps = 27/346 (7%)
Query: 755 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPE------------------LRDLVFSS 796
+ G + ++L +++V ++ F ++R K E +R L + +
Sbjct: 1255 VTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQT 1314
Query: 797 PG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYR 851
PG IP D AD++ + + + F+ +Y+ + G + ++ N KNRY
Sbjct: 1315 PGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID-PGQQFTWENSNLEVNKPKNRYA 1373
Query: 852 NVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQ 911
NV+ YD SRV L I PGSDYINA+++ G +IATQGPLP+T+GDFWR+VWEQ+
Sbjct: 1374 NVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQR 1433
Query: 912 SHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQ 971
+ T+VM+T E RVKC+ YWP T G ++VTL+ + +TVR L +
Sbjct: 1434 TATVVMMTRLEEKSRVKCDQYWPARGTE-TCGLIQVTLLDTVELATYTVRTFALHKSGSS 1492
Query: 972 KTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLI 1031
+ +RQF + AWPDHGVP P +LAF R ++ ++ GP +VHCSAGVGRTG I
Sbjct: 1493 EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC--NPLDAGPMVVHCSAGVGRTGCFI 1550
Query: 1032 ALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
+D +L +++ E + + V MR R MVQTE QYVF+H+ +L
Sbjct: 1551 VIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL 1596
Score = 196 bits (498), Expect = 1e-49
Identities = 104/287 (36%), Positives = 164/287 (57%), Gaps = 6/287 (2%)
Query: 799 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 853
++PA + H++K + +S +++ L S H+ + A+ N KNR N+
Sbjct: 1605 EVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNI 1664
Query: 854 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 913
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL ++ DFWR++WE S
Sbjct: 1665 MPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNST 1724
Query: 914 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 973
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1725 IIVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1783
Query: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
++RQF + WP+ GVP + + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1784 RTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITL 1843
Query: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
++L +++ EG++ F V+ +R RP MVQTE QY ++ L +L
Sbjct: 1844 SIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL 1890
Score = 85.9 bits (211), Expect = 2e-16
Identities = 145/653 (22%), Positives = 250/653 (38%), Gaps = 76/653 (11%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + G+ + VT P P +L V T +S+ LTW+ G + YG+
Sbjct: 296 YTC-VAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGI 352
Query: 155 EYTGDGGRAGTR---STAHTNITVDGLEPGCLYAFSMW----VGKNGINSSRETRNATTA 207
+Y G + A T ++ GL P YAF + +G+ + + R A
Sbjct: 353 QYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA 412
Query: 208 -HNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTET---RNTTDTRV- 262
+P R ++ + S++ + WE P+ + Y V T D R ++ TD +
Sbjct: 413 PSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLL 472
Query: 263 -TVDGLGPGSLYTCSV---WVEKDGVNS-SVEIVTSATAPNPVRNLTVEAQTNSSIALTW 317
TV L PG Y+ V DG S ++++ T P + E ++++ I L+W
Sbjct: 473 TTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSW 532
Query: 318 EVPDGPDPQNSTYGVEY---TGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVW----VGK 370
+P P + Y + Y + + ++ T++ L+P LY F + +G
Sbjct: 533 LLP--PQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGV 590
Query: 371 NGINSSRETRNATTAPN-PVRNLHMETQTNSSIALCWEVP--DGPYPQDYTYWVEYTGDG 427
+ E R A + P+ P + + + ++++ + W P D Y V Y
Sbjct: 591 GVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVD 650
Query: 428 GGTETRNTT------NTSVTAERLEPGTLYTFSVWAEKNGARGSRQN-VSIST---VPNA 477
G R+ ++S LE T Y V A + G + V + T VP+
Sbjct: 651 GEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSG 710
Query: 478 VTSLSKQDWTNST-IALRWTAPQGPGQSSY--SYWVSWVREGMTDPR-------TQSTSG 527
+ + NST + + W P Q Y V++VR +PR
Sbjct: 711 PPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEA 770
Query: 528 TDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAATAPNEVTDLQNETQTKNSVML 583
+ T+ L + Y +TV A + G S T P T + T N+ +L
Sbjct: 771 QETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPT-MMISTTAMNTALL 829
Query: 584 WWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNF 643
W P + +L Y +Q+ R + + N ++ ++ + V L GT Y F
Sbjct: 830 QWHPPKELPGELLGYRLQYC------RADEARPNTID--FGKDDQHFTVTGLHKGTTYIF 881
Query: 644 TVWA-------ERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCP 689
+ A E + T S +P + +T +++ L W P
Sbjct: 882 RLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTST----TELAWDPP 930
Score = 80.9 bits (198), Expect = 6e-15
Identities = 167/769 (21%), Positives = 287/769 (37%), Gaps = 108/769 (14%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTG---DGGTTETRNTTATNVTV 86
P P +L V T +S++L+W+ G + Y +Q +G E T ++
Sbjct: 319 PKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSI 376
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAP-NPVRNLRVEAQTNSSIALTWEV 141
GL P S Y V + + + +V T AP +P R ++ + S++ + WE
Sbjct: 377 GGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP 436
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHTN-----ITVDGLEPGCLYAFSMW----VGK 192
P+ P+ Y V YT D R H TV L PG Y+ + VG
Sbjct: 437 PEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGD 496
Query: 193 NGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRT 252
+ + + + + + E ++ + I LSW +P PQ +
Sbjct: 497 GPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLP----PQERIIMYELVYWAAED 552
Query: 253 ETRN---TTD--TRVTVDGLGPGSLYTCSVWVEKD-GV---NSSVEIVTSATAPN-PVRN 302
E + T D + T++ L P +LY + D GV ++E T+ + P+ P +
Sbjct: 553 EDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQK 612
Query: 303 LTVEAQTNSSIALTWEVPDGPDPQN---STYGVEYTGDGGRAGTR------STAHTNITV 353
+ + ++++ ++W VP D +N + Y V Y G R S H++ +
Sbjct: 613 VMCVSMGSTTVRVSW-VPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDL 671
Query: 354 DRLEPGCLYVFSVW------VGKNGINSSRETRNATTAPN-PVRNLHMETQTNSSIALCW 406
LE Y VW VG +S R P+ P R + +E ++++ + W
Sbjct: 672 VGLEKWTEY--RVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYW 729
Query: 407 E--VPDGPYPQDYTYWVEY----TGDGGG---------TETRNTTNTSVTAERLEPGTLY 451
+ VP + Q Y V Y G+ G E + TT + +T P T Y
Sbjct: 730 KLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLT-----PETTY 784
Query: 452 TFSVWAEKNGARGSRQNVSISTVPNAV---TSLSKQDWTNSTIALRWTAPQGPGQSSYSY 508
+ +V A G+R I T AV ++ +T L+W P+ Y
Sbjct: 785 SVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGY 844
Query: 509 WVSWVREGMTDPRTQSTSGTD--ITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN 566
+ + R P T D T+ L G+ Y + A+ G T P
Sbjct: 845 RLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRT-PE 903
Query: 567 EV-----TDLQNETQTKNSVMLWWKAP--GDPHSQLYVYWVQWASKGHPRRGQDPQANWV 619
++ +L T ++ L W P + + ++ Y V + + Q
Sbjct: 904 DLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQ------- 956
Query: 620 NQTSRTNETWYKVEALEPGTLYNFTV--WAERND--VASSTQSL---CASTYPDTVTITS 672
+ T +T + + L+P T Y+ V W + ++ S QS + + +
Sbjct: 957 ---NITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAA 1013
Query: 673 CVSTSAGYGVNLIWSCPQGGYEA--FELEVGGQRGSQDRSSCGEAVSVL 719
+ TS V L W P A F++ GQ D S + ++ L
Sbjct: 1014 AMKTS----VLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADL 1058
Score = 67.8 bits (164), Expect = 6e-11
Identities = 114/495 (23%), Positives = 186/495 (37%), Gaps = 47/495 (9%)
Query: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN---SNYWVQCTGDGGTTETRNT 79
T P+ P + + V +T+ + +SW VP DS+N + Y V G R+
Sbjct: 601 TAQSTPSAPPQKVMCVSMGSTT-VRVSW-VPPPADSRNGVITQYSVAYEAVDGEDRGRHV 658
Query: 80 ----TATNVTVDGLGPGSLYTCSVWVEKD-----GVNSSVGTVTTA--TAPNPVRNLRVE 128
+ + + D +G VWV G SS V T P R + VE
Sbjct: 659 VDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVE 718
Query: 129 AQTNSSIALTWEVPDGPDPQNSTYGVEYT----GDGGRAGTRSTAHTNI------TVDGL 178
++++ + W++P G + T +G G + T+ GL
Sbjct: 719 PLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGL 778
Query: 179 EPGCLYAFSM--WVGKNGINSSRETRNATTAHNPVR-NLRVEAQTTSSISLSWEVPDGTD 235
P Y+ ++ + K S+ TT P R + + ++ L W P
Sbjct: 779 TPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELP 838
Query: 236 PQNSTYCVQ-CTGDGGRTETRN--TTDTRVTVDGLGPGSLYTCSVWVEKD---GVNSSVE 289
+ Y +Q C D R T + D TV GL G+ Y + + G E
Sbjct: 839 GELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE 898
Query: 290 IVTSATAPNPV-RNLTVEAQTNSSIALTWEVPDGPDPQNS--TYGVEYTGDGGRAGTRS- 345
I T P+ +NL V T S+ L W+ P + +Y V + + ++
Sbjct: 899 IRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNI 958
Query: 346 TAHTNITVDRLEPGCLYVFSV--WVGKNG--INSSRETRNATTAPNPVRNLHMETQTNSS 401
T T T+ L+P Y V W K ++ S ++R +N + +S
Sbjct: 959 TTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTS 1018
Query: 402 IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNG 461
+ L WEVPD Y + + Y G E + + A+ L+P T Y+F + +
Sbjct: 1019 VLLSWEVPDS-YKSAVPFKILYNGQ--SVEVDGHSMRKLIAD-LQPNTEYSFVLMNRGSS 1074
Query: 462 ARGSRQNVSISTVPN 476
A G + VSI T P+
Sbjct: 1075 AGGLQHLVSIRTAPD 1089
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 238 bits (607), Expect = 2e-62
Identities = 124/282 (43%), Positives = 172/282 (60%), Gaps = 5/282 (1%)
Query: 800 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859
I + F HV + ++N F +++ +L S A N AKNR+ N+ PY+ +
Sbjct: 1983 ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNN 2042
Query: 860 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 919
RV L PGSDYINAS++ G P EFIATQGPLP TVGDFWR+VWE ++ TLVMLT
Sbjct: 2043 RVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLT 2102
Query: 920 NCMEAGRVKCEHYWPLDSQPCT-HGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQ 978
C E GR++C YWP D++P T G + +T + E+V +WT+R+L + ++VRQ
Sbjct: 2103 QCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQ 2160
Query: 979 FHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLR 1038
++ AWP+HGVP + L+ F +++R + + P IVHCSAGVGRTG IALD L +
Sbjct: 2161 CNFTAWPEHGVPENSAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQ 2218
Query: 1039 QLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
+ + + V ++R R MVQ AQY+FLHQCIL L
Sbjct: 2219 HINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL 2260
Score = 76.3 bits (186), Expect = 2e-13
Identities = 101/443 (22%), Positives = 163/443 (36%), Gaps = 53/443 (11%)
Query: 79 TTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTA--TAPNPVRNLRVEAQTNSSIA 136
T+ T V V + PG+ Y ++ S V + T T P P L E ++ I
Sbjct: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
Query: 137 LTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTA------HTNITVDGLEPGCLYAFSMWV 190
L+W P P+ + +Y V+Y T T + + L PG Y +
Sbjct: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
Query: 191 GKN-GINSSRET---RNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCT 246
+ GI + + A +A V NL VEA S++ L W +P + + +++ +
Sbjct: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
Query: 247 GDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPV--RNLT 304
+ D + V+ + G L C+ +S + S +P+P R
Sbjct: 194 HARSGIVVK---DVSIRVEDILTGKLPECN--------ENSESFLWSTASPSPTLGRVTP 242
Query: 305 VEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVF 364
T+SS LT QN V + V L P Y+F
Sbjct: 243 PSRTTHSSSTLT---------QNEISSVW------------KEPISFVVTHLRPYTTYLF 281
Query: 365 SVWVGKN--GINSSRETRNATTAPN-PVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWV 421
V G S R + P P +N T S ++ W+ P ++Y V
Sbjct: 282 EVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT-IVTGKFSYRV 340
Query: 422 EYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSIST---VPNAV 478
E G G +T + L P T+Y + AE + G + N+S+ T VP AV
Sbjct: 341 ELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAV 400
Query: 479 TSLSKQDWTNSTIALRWTAPQGP 501
L + ++ + + W P+ P
Sbjct: 401 FDLQLAEVESTQVRITWKKPRQP 423
Score = 73.2 bits (178), Expect = 1e-12
Identities = 141/658 (21%), Positives = 252/658 (38%), Gaps = 80/658 (12%)
Query: 104 DGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGV-EYTGDGGR 162
+G + + T P+ ++ + + ++SSI L W+ P+ P+ + + Y + D R
Sbjct: 554 EGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR 613
Query: 163 AGTRSTAHTNITVDGLEPGCLY----AFSMWVGKNGINSSRETRNATTAHNP---VRNLR 215
A +T + + GL+ Y A S VG++ ++ + T+ P +++
Sbjct: 614 AFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVE 673
Query: 216 VEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTC 275
V T I L W P+ + Y V + +NT+ T + + L P +LY
Sbjct: 674 VIDVTADEIRLKWSPPEKPNGIIIAYEV-LYKNIDTLYMKNTSTTDIILRNLRPHTLYNI 732
Query: 276 SV-----WVEKDGVNSSVEIVTSATAPNPV-RNLTVEAQTNSSIALTWEVPDGPDPQNST 329
SV + + V+S + + TS T P+ N+T + ++ I L++ P P+
Sbjct: 733 SVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQK 792
Query: 330 YGVEY-TGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGK---NGINSSR-ETRNATT 384
Y + +G T +T + L+ Y+ V G+ S+
Sbjct: 793 YTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEED 852
Query: 385 AP-NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAE 443
AP +P ++ ++ + ++ L W+ P P Y+ Y + +T N T TS+
Sbjct: 853 APDSPPQDFSVKQLSGVTVKLSWQPPLEP-NGIILYYTVYVWNRSSLKTINVTETSLELS 911
Query: 444 RLEPGTLYTFSVWAEKNGARG-SRQNVSISTVPNAVTSLSKQD-----WTNSTIALRWTA 497
L+ Y+ V A G +R N+ P S +D ++S+I L WT
Sbjct: 912 DLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTP 971
Query: 498 PQGPGQSSYSYWVSWVREGMTDPRTQSTSGT---DITLKEL--EAGSLYHLTVWAERNEV 552
P P Y V + ++TSGT + TL E+ + ++ T+ +
Sbjct: 972 PSKPNGIIQYYSVYY----------RNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIF 1021
Query: 553 RGYNSTLTAATAPNE--------------------VTDLQNETQTKNSVMLWWKAPGDPH 592
Y LTA+T+ V +L E+ + ++ + W P P+
Sbjct: 1022 SYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPN 1081
Query: 593 SQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLY--NFTVWAERN 650
L Y+V + PR + P T E + LE T Y T E+
Sbjct: 1082 G-LVFYYVSLILQQTPRHVRPPLV--------TYERSIYFDNLEKYTDYILKITPSTEKG 1132
Query: 651 DVASSTQSLCAST---YPDTVTITSCVSTSAGYGVNLIWS---CPQGGYEAFELEVGG 702
+ T L T P+T I + + V L W P G +++L + G
Sbjct: 1133 FSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQG 1190
Score = 64.7 bits (156), Expect = 5e-10
Identities = 161/711 (22%), Positives = 267/711 (37%), Gaps = 74/711 (10%)
Query: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTAT 82
T P +P +++ V T I L W P+ + Y V T +NT+ T
Sbjct: 660 TSEDEPESSP-QDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNID-TLYMKNTSTT 717
Query: 83 NVTVDGLGPGSLYTCSV-----WVEKDGVNSSVGTVTTATAPNPV-RNLRVEAQTNSSIA 136
++ + L P +LY SV + + V+S + T+ T P+ N+ + ++ I
Sbjct: 718 DIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIE 777
Query: 137 LTWEVPDGPDPQNSTYGVEY-TGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGK--- 192
L++ P P+ Y + +G T +T + L+ Y +
Sbjct: 778 LSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKG 837
Query: 193 NGINSSRET--RNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQN-STYCVQCTGDG 249
G+ S+ + +P ++ V+ + ++ LSW+ P +P Y +
Sbjct: 838 EGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPP--LEPNGIILYYTVYVWNR 895
Query: 250 GRTETRNTTDTRVTVDGLGPGSLYTCSVWVEK---DGVNSS--VEIVTSATAP-NPVRNL 303
+T N T+T + + L Y+ V DG S + T AP +P +++
Sbjct: 896 SSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDV 955
Query: 304 TVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH------TNITV---- 353
++SSI L W P P+ Y V Y G T H N+TV
Sbjct: 956 YYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTII 1015
Query: 354 DRLEPGCLYVF----SVWVGKNGINSSRETRNATTAPNP---VRNLHMETQTNSSIALCW 406
D+L Y F S VG NG SS T P V NL E+ ++++I + W
Sbjct: 1016 DKLTIFSYYTFWLTASTSVG-NGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSW 1074
Query: 407 EVPDGPYPQDYTYWVEYTGDGGGTETRN---TTNTSVTAERLEPGTLYTFSVW--AEKNG 461
P P + Y+V R T S+ + LE T Y + EK
Sbjct: 1075 VPPAQPNGLVF-YYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGF 1133
Query: 462 ARGSRQNVSIST---VPNAVTSLSK-QDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGM 517
+ + I T VP ++ ++ +++++ L W P P + SY +G
Sbjct: 1134 SDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISY--DLTLQGP 1191
Query: 518 TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTL------TAATAPNEVTDL 571
+ + TS I L+EL +LY A + G +S L + AP + L
Sbjct: 1192 NENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTL 1251
Query: 572 QNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYK 631
N T + V L W P + VY + K H + + N + E K
Sbjct: 1252 IN--CTSDFVWLKWSPSPLPGGIVKVY----SFKIHEH--ETDTIYYKNISGFKTEA--K 1301
Query: 632 VEALEPGTLYN-----FTVWAERNDVASSTQSLCASTYPDTVTITSCVSTS 677
+ LEP + Y+ FT N ++ + + PD V C++TS
Sbjct: 1302 LVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATS 1352
Score = 58.9 bits (141), Expect = 3e-08
Identities = 106/458 (23%), Positives = 166/458 (36%), Gaps = 62/458 (13%)
Query: 168 TAHTNITVDGLEPGCLYAFSMWVGKNGINS--SRETRNATTAHNPVRNLRVEAQTTSSIS 225
T+ T + V + PG Y ++ S +R T P L E ++ I
Sbjct: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
Query: 226 LSWEVPDGTDPQNSTYCVQCTG-----DGGRTETRNTTDT-RVTVDGLGPGSLYTCSVWV 279
LSW P + + +Y V+ T+ R+ D+ V + L PG+ Y V
Sbjct: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
Query: 280 EKD---GVNSSVEIV-TSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTY--GVE 333
E GV S + T+ +AP V NLTVEA S++ L W +P P+ + +++ V+
Sbjct: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
Query: 334 YTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLH 393
+ G S +I +L P C ++ S T T P+ R H
Sbjct: 194 HARSGIVVKDVSIRVEDILTGKL-PECNENSESFLWSTA--SPSPTLGRVTPPS--RTTH 248
Query: 394 ME-TQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYT 452
T T + I+ W+ P S L P T Y
Sbjct: 249 SSSTLTQNEISSVWKEP----------------------------ISFVVTHLRPYTTYL 280
Query: 453 FSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDW-----TNSTIALRWTAPQ-GPGQSSY 506
F V A A + +I P +V Q+ T + ++ W P G+ SY
Sbjct: 281 FEVSAATTEA--GYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPTIVTGKFSY 338
Query: 507 SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN 566
+ + D ST L ++Y + + AE + G S ++ T P+
Sbjct: 339 RVELYGPSGRILD---NSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPD 395
Query: 567 ---EVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQ 601
V DLQ V + WK P P+ + Y V+
Sbjct: 396 VPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVK 433
Score = 51.2 bits (121), Expect = 5e-06
Identities = 89/409 (21%), Positives = 142/409 (34%), Gaps = 67/409 (16%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNY---------WVQCTGDGGTTETRNTT 80
P P L E ++ I LSW P + + +Y W+Q T+ R+
Sbjct: 56 PGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTV----YTQVRSKP 111
Query: 81 -ATNVTVDGLGPGSLYTCSVWVEKD---GVNSSVGTVTTA-TAPNPVRNLRVEAQTNSSI 135
+ V + L PG+ Y V E GV S TA +AP V NL VEA S++
Sbjct: 112 DSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAV 171
Query: 136 ALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGI 195
L W +P P+ + +++ + A + I V +
Sbjct: 172 KLIWYLPRQPNGKITSFKISV----------KHARSGIVVKDV----------------- 204
Query: 196 NSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETR 255
S + T P N E+ S+ S S + T P +T+ T T+
Sbjct: 205 --SIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTH-------SSSTLTQ 255
Query: 256 NTTDT------RVTVDGLGPGSLYTCSV---WVEKDGVNSSVEIVTSATAPNPVRNLTVE 306
N + V L P + Y V E ++S++ + P +N
Sbjct: 256 NEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTG 315
Query: 307 AQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCL---YV 363
T S ++ W+ P + S Y VE G GR ST L P + Y+
Sbjct: 316 NITGKSFSILWDPPTIVTGKFS-YRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYI 374
Query: 364 FSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGP 412
+ G S+ P V +L + ++ + + W+ P P
Sbjct: 375 AAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQP 423
Score = 50.8 bits (120), Expect = 7e-06
Identities = 50/189 (26%), Positives = 79/189 (41%), Gaps = 16/189 (8%)
Query: 435 TTNTSVTAERLEPGTLY--TFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIA 492
T+ T V + PGT Y T S + + +R + T P L+ + ++ I
Sbjct: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
Query: 493 LRWTAPQGPGQSSYSYWVS------WVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 546
L W P P SY V W++ T R++ S ++ L L G+ Y + V
Sbjct: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDS-LEVLLTNLNPGTTYEIKVA 132
Query: 547 AERNEVRGYNST----LTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 602
AE + G S TA +AP +V +L E ++V L W P P+ ++ + +
Sbjct: 133 AENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKI-- 190
Query: 603 ASKGHPRRG 611
S H R G
Sbjct: 191 -SVKHARSG 198
Score = 48.9 bits (115), Expect = 3e-05
Identities = 120/521 (23%), Positives = 194/521 (37%), Gaps = 70/521 (13%)
Query: 31 NPGRNLTVETQTTSSISLSW---EVPDGLDSQNSNYWVQCTGD--------GGTTETRNT 79
+P +++ ++SSI L W P+G+ S Y+ +G T + N
Sbjct: 950 DPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNM 1009
Query: 80 TATNVTVDGLGPGSLYT----CSVWVEKDGVNSSVGTV-TTATAPNP-VRNLRVEAQTNS 133
T + + +D L S YT S V +S + V T P V NL E+ +++
Sbjct: 1010 TVSTI-IDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISST 1068
Query: 134 SIALTWEVPDGPDPQNSTYGVEYTGDGGR--AGTRSTAHTNITVDGLE----------PG 181
+I ++W P P+ Y R T +I D LE P
Sbjct: 1069 AINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPS 1128
Query: 182 CLYAFS-MWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNST 240
FS + + I + + + N +NL +++S+ LSW+ P P +
Sbjct: 1129 TEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNL-----SSTSVLLSWDPP--VKPNGAI 1181
Query: 241 YCVQCTGDG-GRTETRNTTDTRVTVDGLGPGSLYT--CSVWVEKD-GVNSSVEIVTSATA 296
T G + T+D + ++ L P +LY+ + K G +S + T +
Sbjct: 1182 ISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESV 1241
Query: 297 P-NPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV---EYTGDGGRAGTRSTAHTNIT 352
P P +NLT+ T+ + L W P Y E+ D S T
Sbjct: 1242 PLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAK 1301
Query: 353 VDRLEPGCLYVFSVW----VGKNGINSSRETRNAT--TAPNPVRNLHMETQTNSSIALCW 406
+ LEP Y V VG NG S + T + P+ V+N+ + S+ + W
Sbjct: 1302 LVGLEPVSTYSIRVSAFTKVG-NGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKW 1360
Query: 407 EVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTS-----VTAERLEPGTLYTFSVWAEKNG 461
+ P Y V T RN+T S T +L T Y F V A +
Sbjct: 1361 DPPKKANGIITQYMV--------TVERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSA 1412
Query: 462 ARGSRQNVSISTVPNAV----TSLSKQDWTNSTIALRWTAP 498
G +ST+P V T+++ D +++ L W P
Sbjct: 1413 GEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRP 1453
Score = 34.3 bits (77), Expect = 0.68
Identities = 73/308 (23%), Positives = 118/308 (38%), Gaps = 34/308 (11%)
Query: 37 TVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN-VTVDGLGPGSLY 95
T + +++S+ LSW+ P + +Y T G T+ N + ++ L P +LY
Sbjct: 1158 TFKNLSSTSVLLSWDPPVKPNGAIISY--DLTLQGPNENYSFITSDNYIILEELSPFTLY 1215
Query: 96 T--CSVWVEKD-GVNSSVGTVTTATAP-NPVRNLRVEAQTNSSIALTWEVPDGPDPQNST 151
+ + K G +S + T + P P +NL + T+ + L W P
Sbjct: 1216 SFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKV 1275
Query: 152 YGV---EYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMW----VGKNGINSSRETRNA 204
Y E+ D S T + GLEP Y+ + VG NG S +
Sbjct: 1276 YSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVG-NGNQFSNVVKFT 1334
Query: 205 TTAHNP--VRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTT---- 258
T P V+N++ A + S+ + W+ P + + Y V T RN+T
Sbjct: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV--------TVERNSTKVSP 1386
Query: 259 -DTRVTVDGLGPGSLYTCSVWVEK---DGVNSSVEIVT-SATAPNPVRNLTVEAQTNSSI 313
D T L + Y V +G S+ + T T P+ N+ ++S
Sbjct: 1387 QDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSA 1446
Query: 314 ALTWEVPD 321
LTW PD
Sbjct: 1447 TLTWIRPD 1454
Score = 31.6 bits (70), Expect = 4.4
Identities = 64/321 (19%), Positives = 116/321 (36%), Gaps = 35/321 (10%)
Query: 32 PGRNLTVETQTTSSISLSWE---VPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDG 88
P +NLT+ T+ + L W +P G+ S + D + + T + G
Sbjct: 1245 PPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVG 1304
Query: 89 LGPGSLYTCSVWV-EKDGVNSSVGTV----TTATAPNPVRNLRVEAQTNSSIALTWEVPD 143
L P S Y+ V K G + V T + P+ V+N++ A + S+ + W+ P
Sbjct: 1305 LEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPK 1364
Query: 144 GPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRN 203
+ + Y V + + + +T I L Y F + + T +
Sbjct: 1365 KANGIITQYMVTVERNSTKVSPQDHMYTFIK---LLANTSYVFKVRASTSAGEGDESTCH 1421
Query: 204 ATTAHNPV----RNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTD 259
+T V N+ ++S +L+W PD Y + + + + +
Sbjct: 1422 VSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEE 1481
Query: 260 ---------------TRVTVDGLGPGSLYTCSVWVEKD-GVNSSVEIVTSATAP----NP 299
T TV GL Y V + G ++ +++ T P P
Sbjct: 1482 CVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGP 1541
Query: 300 VRNLTVEAQTNSSIALTWEVP 320
N+ V A + SI+++W P
Sbjct: 1542 PENVHVVATSPFSISISWSEP 1562
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 237 bits (605), Expect = 4e-62
Identities = 118/278 (42%), Positives = 170/278 (61%), Gaps = 5/278 (1%)
Query: 800 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859
I D H+ + + GF ++Y+ G S S VA +N AKNRY N++ YD S
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESF-FEGQSASWDVAKKDQNRAKNRYGNIIAYDHS 926
Query: 860 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 919
RV L+P+ ++P SDYINA+++ G P +IATQGP+ +TV DFWR++W++QS +VM+T
Sbjct: 927 RVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVT 986
Query: 920 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 979
N +E GRVKC YWP D++ +G +VT V E + + VR L + + V+QF
Sbjct: 987 NLVEVGRVKCYKYWPDDTE--VYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQF 1044
Query: 980 HYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQ 1039
H+ WPDHGVP LL+F R ++ L GP +VHCSAG GRTG I +D++L
Sbjct: 1045 HFTGWPDHGVPYHATGLLSFIRRVK--LSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDM 1102
Query: 1040 LQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
+ EG++ ++ V+ +R R MVQTE QY+F+H IL
Sbjct: 1103 AEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL 1140
Score = 125 bits (314), Expect = 2e-28
Identities = 87/287 (30%), Positives = 144/287 (50%), Gaps = 13/287 (4%)
Query: 805 FADHVRKNERDSNCGFADKYQQLSLVG---HSQSQMVASASENNAKNRYRNVLPYDWSRV 861
+ D +R + + ++ D++Q L+ V ++ +A N+ KNR+ ++LP D
Sbjct: 1159 YFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLP 1218
Query: 862 PLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNC 921
L I E S+YINA+ M P FI TQ PLP TV DFWRLV++ ++VML
Sbjct: 1219 FLITIDGE-SSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV 1277
Query: 922 -MEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVR--ELLLLQVEEQKTLSVRQ 978
+ G C YWP + +G ++V + + + R + L ++ L V+Q
Sbjct: 1278 DLSQG---CPQYWPEEGM-LRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQ 1333
Query: 979 FHYQAWPDH-GVPSSPDTLLAFWRMLRQWLDQTMEG-GPPIVHCSAGVGRTGTLIALDVL 1036
F Y W H VP S + L + +W ++ EG G I+HC G GR+G A+ ++
Sbjct: 1334 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1393
Query: 1037 LRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQS 1083
+ ++ + ++ F V+ +R S+P MV+ QY F + L +L+ S
Sbjct: 1394 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS 1440
Score = 34.7 bits (78), Expect = 0.52
Identities = 31/124 (25%), Positives = 48/124 (38%), Gaps = 15/124 (12%)
Query: 565 PNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSR 624
P V LQ T +N + L WK P DP+ + Y + ++S R DP
Sbjct: 492 PVPVKSLQG-TSFENKIFLNWKEPLDPNGIITQYEISYSS----IRSFDPAVPVAGPPQT 546
Query: 625 TNETWYKVE----ALEPGTLYNFTVWAER------NDVASSTQSLCASTYPDTVTITSCV 674
+ W L PGT Y F + A + T ++ A T PD + + +
Sbjct: 547 VSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASL 606
Query: 675 STSA 678
+ +A
Sbjct: 607 NETA 610
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 236 bits (602), Expect = 9e-62
Identities = 128/345 (37%), Positives = 189/345 (54%), Gaps = 26/345 (7%)
Query: 755 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP-----------------ELRDLVFSSP 797
+ G + ++ + +V ++ + ++R + +K ELR L F +P
Sbjct: 1270 VVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP 1329
Query: 798 G-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRN 852
G IP + ADH+ + + + N F+ +Y+ + G + ++ N KNRY N
Sbjct: 1330 GMASHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYAN 1388
Query: 853 VLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQS 912
V+ YD SRV L I PGSDY+NA+++ G +IATQG LP+T GDFWR++WEQ+S
Sbjct: 1389 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1448
Query: 913 HTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK 972
T+VM+T E RVKC+ YWP THG ++VTL+ + + VR L + +
Sbjct: 1449 ATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRTFALYKNGSSE 1507
Query: 973 TLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIA 1032
VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG I
Sbjct: 1508 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTGCFIV 1565
Query: 1033 LDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
+D +L +++ E + + V MR R MVQTE QY+F+H +L
Sbjct: 1566 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1610
Score = 199 bits (507), Expect = 9e-51
Identities = 107/287 (37%), Positives = 167/287 (58%), Gaps = 6/287 (2%)
Query: 799 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 853
++PA + +++K + ++ G ++++L S H+ + A+ N KNR N+
Sbjct: 1619 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1678
Query: 854 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 913
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL +T DFWR++WE S
Sbjct: 1679 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1738
Query: 914 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 973
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1739 IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1797
Query: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
+VRQF + WP+ GVP S + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1798 RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITL 1857
Query: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
++L +++ EG++ F V+ +R RP MVQTE QY F ++ L +L
Sbjct: 1858 SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1904
Score = 94.0 bits (232), Expect = 7e-19
Identities = 177/795 (22%), Positives = 300/795 (37%), Gaps = 89/795 (11%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGT---TETRNTTATNVTV 86
P P V T +SI+L+W+ G S Y +Q E T +V
Sbjct: 323 PKPPGTPVVTESTATSITLTWD--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSV 380
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPV-RNLRVEAQTNSSIALTWEV 141
GL P S Y V + + + V T T+ AP+ R+++ ++++I + W+
Sbjct: 381 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDGLEPGCLYAFSMW----VGK 192
P+ P+ Q Y V YT D + H T+ L P Y+ + +G
Sbjct: 441 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 500
Query: 193 NGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRT 252
++S + T N + E ++ +SI LSW P +D + V G+ G
Sbjct: 501 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSW-TPPRSDTIANYELVYKDGEHGE- 558
Query: 253 ETRNTTD--TRVTVDGLGPGSLYTCSVWVEK-DGVNSSVEIVTSATAPN----PVRNLTV 305
E R T + T + GL P SLY + G+ +S +++ T + P ++++
Sbjct: 559 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 618
Query: 306 EAQTNSSIALTWEVPDGPDPQN---STYGVEYTGDGGR-------AGTRSTAHTNITVDR 355
+ +++SI ++W+ P + QN + Y ++YT G G S T +++
Sbjct: 619 TSPSSTSILVSWQ-PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDT-TKYLLEQ 676
Query: 356 LEPGCLYVFSVW----VGKNGINSSRETRNATTAPN-PVRNLHMETQTNSSIALCWE--V 408
LE Y +V VG + S R P+ P R + +E ++S+ + W V
Sbjct: 677 LEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPV 736
Query: 409 PDGPYPQDYTYWVEYTGDGGGT-----------------ETRNTTNTSVTAERLEPGTLY 451
P+ + Q Y V Y G E +TT + L+P T Y
Sbjct: 737 PNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSY 796
Query: 452 TFSVWAEKNGARGSRQNVSISTVPNAVTS---LSKQDWTNSTIALRWTAPQGPGQSSYSY 508
+ +V A G+R + + AV L +T ++W P Y
Sbjct: 797 SLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 856
Query: 509 WVSWVREGMTDPRTQSTSGTD--ITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN 566
+ + R+ M T S + T ++ G+ Y + A RN+V + + P
Sbjct: 857 RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA-RNKVGFGEEMVKEISIPE 915
Query: 567 EV-----TDLQNETQTKNSVMLWWKAP--GDPHSQLYVYWVQWASKGHPRRGQDPQANWV 619
EV +L +E T SV L W+ P + + + Y + + P +
Sbjct: 916 EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME------ 969
Query: 620 NQTSRTNETWYKVEALEPGTLYNFTVWAERN-DVASSTQSLCASTYP-DTVTITSC-VST 676
Q +T + L+P T Y+ V A + + S+ T P D V + V
Sbjct: 970 -QLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKA 1028
Query: 677 SAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVS--VLGLGPARSYPATITTI 734
V L W P+ A ++ G G A ++ L P +SY +T
Sbjct: 1029 VMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNR 1088
Query: 735 WDGMKVVSHSVVCHT 749
+ + H V T
Sbjct: 1089 GNSAGGLQHRVTAKT 1103
Score = 88.2 bits (217), Expect = 4e-17
Identities = 135/571 (23%), Positives = 225/571 (39%), Gaps = 67/571 (11%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + GV ++ +T P P V T +SI LTW+ P+P S Y +
Sbjct: 300 YTC-VAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPV-SYYII 356
Query: 155 EYTGDGGRAGTRS---TAHTNITVDGLEPGCLYAFSMWVGKNGINS---SRETRNATTAH 208
++ + A T +V GL P Y F + V N I S T+
Sbjct: 357 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRV-VAVNNIGRGPPSEPVLTQTSEQ 415
Query: 209 NPV---RNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETR----NTTDTR 261
P R+++ ++++I + W+ P+ + Q Y V T D + N D++
Sbjct: 416 APSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 475
Query: 262 VTVDG-LGPGSLYTCSVWVEK---DG-VNSSVEIVTSATAPNPVRNLTVEAQTNSSIALT 316
+T G L P Y+ V DG ++S ++++T P N E ++ +SI L+
Sbjct: 476 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS 535
Query: 317 WEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH--TNITVDRLEPGCLYVFSVWV-GKNGI 373
W P N Y + Y R T T+ + L+P LY F + G+
Sbjct: 536 WTPPRSDTIAN--YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGL 593
Query: 374 NSSRETRNATTAPN----PVRNLHMETQTNSSIALCWEVPDGPYPQDY--TYWVEYTGDG 427
+S +A T + P +++ + +++SI + W+ P Y ++YT
Sbjct: 594 GASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVD 653
Query: 428 GGTETRN------TTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQ-NVSIST---VPNA 477
G + + + T E+LE T Y +V A + G +V I T VP+
Sbjct: 654 GEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSG 713
Query: 478 VTSLSKQDWTNST-IALRWTAPQGPGQSSY--SYWVSWVREGMTDPRTQ----------- 523
+ + NST + + W +P Q Y V +VR +P+ Q
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 524 -----STSGTDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAATAPNEVTDLQNE 574
T+ D+ + L+ + Y LTV A + G S T P + + N
Sbjct: 774 QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINH 833
Query: 575 TQTKNSVMLWWKAPGDPHSQLYVYWVQWASK 605
TQ N+ ++ W P D L Y +++ K
Sbjct: 834 TQ-MNTALIQWHPPVDTFGPLQGYRLKFGRK 863
Score = 54.7 bits (130), Expect = 5e-07
Identities = 108/505 (21%), Positives = 194/505 (38%), Gaps = 66/505 (13%)
Query: 32 PGRNLTVETQTTSSISLSWEVPDGLDSQN---SNYWVQCTGDGGTTETRN------TTAT 82
P ++++ + +++SI +SW+ P ++ QN + Y ++ T G + + + T
Sbjct: 612 PPQDISCTSPSSTSILVSWQPPP-VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTT 670
Query: 83 NVTVDGLGPGSLYTCSVWVEKD---GVNS-SVGTVTTATAPN-PVRNLRVEAQTNSSIAL 137
++ L + Y +V D G S SV T P+ P R + VEA ++S+ +
Sbjct: 671 KYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKV 730
Query: 138 TWE--VPDGPDPQNSTYGVEYTG--DGGRAGTR---------------STAHTNITVDGL 178
+W VP+ Q Y V Y +G G T ++ + GL
Sbjct: 731 SWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGL 790
Query: 179 EPGCLYAFSM--WVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISL-SWEVPDGTD 235
+P Y+ ++ + K S+ +TT P + V T + +L W P T
Sbjct: 791 QPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF 850
Query: 236 PQNSTYCVQCTGDGGRTETRNTT-------DTRVTVDGLGPGSLYTCSVWVEKDGVNSSV 288
Y ++ GR + T + T + G+ Y + ++ V
Sbjct: 851 GPLQGYRLKF----GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA-RNKVGFGE 905
Query: 289 EIVTSATAPNPV-----RNLTVEAQTNSSIALTWEVPDGPDPQN--STYGVEYTGDG--- 338
E+V + P V +NL E T++S+ L+W+ P + + Y + Y
Sbjct: 906 EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPL 965
Query: 339 -GRAGTRSTAHTNITVDRLEPGCLYVFSVWV----GKNGINSSRETRNATTAPNPVRNLH 393
A T +T+ L+P Y V G + S + R +N H
Sbjct: 966 LPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFH 1025
Query: 394 METQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTF 453
++ +S+ L WE+P+ Y + + Y DG E + T L+P Y+F
Sbjct: 1026 VKAVMKTSVLLSWEIPEN-YNSAMPFKILY-DDGKMVEEVDGRATQKLIVNLKPEKSYSF 1083
Query: 454 SVWAEKNGARGSRQNVSISTVPNAV 478
+ N A G + V+ T P+ +
Sbjct: 1084 VLTNRGNSAGGLQHRVTAKTAPDVL 1108
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/217 (23%), Positives = 88/217 (40%), Gaps = 15/217 (6%)
Query: 123 RNLRVEAQTNSSIALTWEVPDGPDPQN--STYGVEYTGDG----GRAGTRSTAHTNITVD 176
+NL E T++S+ L+W+ P + + Y + Y A T +T+
Sbjct: 923 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT 982
Query: 177 GLEPGCLYAFSMWV----GKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPD 232
GL+P Y + G + S + R +N V+A +S+ LSWE+P+
Sbjct: 983 GLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1042
Query: 233 GTDPQNSTYCVQCTGDGGR-TETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIV 291
NS + D G+ E + T+ + L P Y+ + + V
Sbjct: 1043 N---YNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRV 1099
Query: 292 TSATAPNPVRNL-TVEAQTNSSIALTWEVPDGPDPQN 327
T+ TAP+ +R +TN +T ++P+ P +N
Sbjct: 1100 TAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 1136
Score = 34.7 bits (78), Expect = 0.52
Identities = 45/190 (23%), Positives = 76/190 (40%), Gaps = 14/190 (7%)
Query: 34 RNLTVETQTTSSISLSWEVP-----DGLDSQNSNYWVQCTGDGGTTETRNTTA-TNVTVD 87
+NL E T++S+ LSW+ P +G+ ++ + + E A T +T+
Sbjct: 923 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT 982
Query: 88 GLGPGSLYTCSVWVEKD-GVNSSVGTVTTATAPNP---VRNLRVEAQTNSSIALTWEVPD 143
GL P + Y V G +V T P +N V+A +S+ L+WE+P+
Sbjct: 983 GLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1042
Query: 144 GPDPQNSTYGVEYTGDGGRAGTRSTAH-TNITVDGLEPGCLYAFSMWVGKNGINSSRETR 202
NS + D G+ T + L+P Y+F + N +
Sbjct: 1043 N---YNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRV 1099
Query: 203 NATTAHNPVR 212
A TA + +R
Sbjct: 1100 TAKTAPDVLR 1109
Score = 34.7 bits (78), Expect = 0.52
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 3/117 (2%)
Query: 34 RNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGS 93
+N V+ +S+ LSWE+P+ +S + + DG E + AT + L P
Sbjct: 1022 KNFHVKAVMKTSVLLSWEIPENYNS--AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEK 1079
Query: 94 LYTCSVWVEKDGVNSSVGTVTTATAPNPVRNL-RVEAQTNSSIALTWEVPDGPDPQN 149
Y+ + + VT TAP+ +R +TN +T ++P+ P +N
Sbjct: 1080 SYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 1136
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 236 bits (602), Expect = 9e-62
Identities = 128/345 (37%), Positives = 189/345 (54%), Gaps = 26/345 (7%)
Query: 755 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP-----------------ELRDLVFSSP 797
+ G + ++ + +V ++ + ++R + +K ELR L F +P
Sbjct: 1257 VVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP 1316
Query: 798 G-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRN 852
G IP + ADH+ + + + N F+ +Y+ + G + ++ N KNRY N
Sbjct: 1317 GMASHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYAN 1375
Query: 853 VLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQS 912
V+ YD SRV L I PGSDY+NA+++ G +IATQG LP+T GDFWR++WEQ+S
Sbjct: 1376 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1435
Query: 913 HTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK 972
T+VM+T E RVKC+ YWP THG ++VTL+ + + VR L + +
Sbjct: 1436 ATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRTFALYKNGSSE 1494
Query: 973 TLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIA 1032
VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG I
Sbjct: 1495 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTGCFIV 1552
Query: 1033 LDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
+D +L +++ E + + V MR R MVQTE QY+F+H +L
Sbjct: 1553 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1597
Score = 199 bits (507), Expect = 9e-51
Identities = 107/287 (37%), Positives = 167/287 (58%), Gaps = 6/287 (2%)
Query: 799 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 853
++PA + +++K + ++ G ++++L S H+ + A+ N KNR N+
Sbjct: 1606 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1665
Query: 854 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 913
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL +T DFWR++WE S
Sbjct: 1666 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1725
Query: 914 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 973
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1726 IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1784
Query: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
+VRQF + WP+ GVP S + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1785 RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITL 1844
Query: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
++L +++ EG++ F V+ +R RP MVQTE QY F ++ L +L
Sbjct: 1845 SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1891
Score = 94.0 bits (232), Expect = 7e-19
Identities = 177/795 (22%), Positives = 300/795 (37%), Gaps = 89/795 (11%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGT---TETRNTTATNVTV 86
P P V T +SI+L+W+ G S Y +Q E T +V
Sbjct: 310 PKPPGTPVVTESTATSITLTWD--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSV 367
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPV-RNLRVEAQTNSSIALTWEV 141
GL P S Y V + + + V T T+ AP+ R+++ ++++I + W+
Sbjct: 368 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 427
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDGLEPGCLYAFSMW----VGK 192
P+ P+ Q Y V YT D + H T+ L P Y+ + +G
Sbjct: 428 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 487
Query: 193 NGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRT 252
++S + T N + E ++ +SI LSW P +D + V G+ G
Sbjct: 488 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSW-TPPRSDTIANYELVYKDGEHGE- 545
Query: 253 ETRNTTD--TRVTVDGLGPGSLYTCSVWVEK-DGVNSSVEIVTSATAPN----PVRNLTV 305
E R T + T + GL P SLY + G+ +S +++ T + P ++++
Sbjct: 546 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 605
Query: 306 EAQTNSSIALTWEVPDGPDPQN---STYGVEYTGDGGR-------AGTRSTAHTNITVDR 355
+ +++SI ++W+ P + QN + Y ++YT G G S T +++
Sbjct: 606 TSPSSTSILVSWQ-PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDT-TKYLLEQ 663
Query: 356 LEPGCLYVFSVW----VGKNGINSSRETRNATTAPN-PVRNLHMETQTNSSIALCWE--V 408
LE Y +V VG + S R P+ P R + +E ++S+ + W V
Sbjct: 664 LEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPV 723
Query: 409 PDGPYPQDYTYWVEYTGDGGGT-----------------ETRNTTNTSVTAERLEPGTLY 451
P+ + Q Y V Y G E +TT + L+P T Y
Sbjct: 724 PNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSY 783
Query: 452 TFSVWAEKNGARGSRQNVSISTVPNAVTS---LSKQDWTNSTIALRWTAPQGPGQSSYSY 508
+ +V A G+R + + AV L +T ++W P Y
Sbjct: 784 SLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 843
Query: 509 WVSWVREGMTDPRTQSTSGTD--ITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN 566
+ + R+ M T S + T ++ G+ Y + A RN+V + + P
Sbjct: 844 RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA-RNKVGFGEEMVKEISIPE 902
Query: 567 EV-----TDLQNETQTKNSVMLWWKAP--GDPHSQLYVYWVQWASKGHPRRGQDPQANWV 619
EV +L +E T SV L W+ P + + + Y + + P +
Sbjct: 903 EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME------ 956
Query: 620 NQTSRTNETWYKVEALEPGTLYNFTVWAERN-DVASSTQSLCASTYP-DTVTITSC-VST 676
Q +T + L+P T Y+ V A + + S+ T P D V + V
Sbjct: 957 -QLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKA 1015
Query: 677 SAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVS--VLGLGPARSYPATITTI 734
V L W P+ A ++ G G A ++ L P +SY +T
Sbjct: 1016 VMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNR 1075
Query: 735 WDGMKVVSHSVVCHT 749
+ + H V T
Sbjct: 1076 GNSAGGLQHRVTAKT 1090
Score = 88.2 bits (217), Expect = 4e-17
Identities = 135/571 (23%), Positives = 225/571 (39%), Gaps = 67/571 (11%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + GV ++ +T P P V T +SI LTW+ P+P S Y +
Sbjct: 287 YTC-VAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPV-SYYII 343
Query: 155 EYTGDGGRAGTRS---TAHTNITVDGLEPGCLYAFSMWVGKNGINS---SRETRNATTAH 208
++ + A T +V GL P Y F + V N I S T+
Sbjct: 344 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRV-VAVNNIGRGPPSEPVLTQTSEQ 402
Query: 209 NPV---RNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETR----NTTDTR 261
P R+++ ++++I + W+ P+ + Q Y V T D + N D++
Sbjct: 403 APSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 462
Query: 262 VTVDG-LGPGSLYTCSVWVEK---DG-VNSSVEIVTSATAPNPVRNLTVEAQTNSSIALT 316
+T G L P Y+ V DG ++S ++++T P N E ++ +SI L+
Sbjct: 463 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS 522
Query: 317 WEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH--TNITVDRLEPGCLYVFSVWV-GKNGI 373
W P N Y + Y R T T+ + L+P LY F + G+
Sbjct: 523 WTPPRSDTIAN--YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGL 580
Query: 374 NSSRETRNATTAPN----PVRNLHMETQTNSSIALCWEVPDGPYPQDY--TYWVEYTGDG 427
+S +A T + P +++ + +++SI + W+ P Y ++YT
Sbjct: 581 GASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVD 640
Query: 428 GGTETRN------TTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQ-NVSIST---VPNA 477
G + + + T E+LE T Y +V A + G +V I T VP+
Sbjct: 641 GEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSG 700
Query: 478 VTSLSKQDWTNST-IALRWTAPQGPGQSSY--SYWVSWVREGMTDPRTQ----------- 523
+ + NST + + W +P Q Y V +VR +P+ Q
Sbjct: 701 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 760
Query: 524 -----STSGTDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAATAPNEVTDLQNE 574
T+ D+ + L+ + Y LTV A + G S T P + + N
Sbjct: 761 QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINH 820
Query: 575 TQTKNSVMLWWKAPGDPHSQLYVYWVQWASK 605
TQ N+ ++ W P D L Y +++ K
Sbjct: 821 TQ-MNTALIQWHPPVDTFGPLQGYRLKFGRK 850
Score = 54.7 bits (130), Expect = 5e-07
Identities = 108/505 (21%), Positives = 194/505 (38%), Gaps = 66/505 (13%)
Query: 32 PGRNLTVETQTTSSISLSWEVPDGLDSQN---SNYWVQCTGDGGTTETRN------TTAT 82
P ++++ + +++SI +SW+ P ++ QN + Y ++ T G + + + T
Sbjct: 599 PPQDISCTSPSSTSILVSWQPPP-VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTT 657
Query: 83 NVTVDGLGPGSLYTCSVWVEKD---GVNS-SVGTVTTATAPN-PVRNLRVEAQTNSSIAL 137
++ L + Y +V D G S SV T P+ P R + VEA ++S+ +
Sbjct: 658 KYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKV 717
Query: 138 TWE--VPDGPDPQNSTYGVEYTG--DGGRAGTR---------------STAHTNITVDGL 178
+W VP+ Q Y V Y +G G T ++ + GL
Sbjct: 718 SWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGL 777
Query: 179 EPGCLYAFSM--WVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISL-SWEVPDGTD 235
+P Y+ ++ + K S+ +TT P + V T + +L W P T
Sbjct: 778 QPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF 837
Query: 236 PQNSTYCVQCTGDGGRTETRNTT-------DTRVTVDGLGPGSLYTCSVWVEKDGVNSSV 288
Y ++ GR + T + T + G+ Y + ++ V
Sbjct: 838 GPLQGYRLKF----GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA-RNKVGFGE 892
Query: 289 EIVTSATAPNPV-----RNLTVEAQTNSSIALTWEVPDGPDPQN--STYGVEYTGDG--- 338
E+V + P V +NL E T++S+ L+W+ P + + Y + Y
Sbjct: 893 EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPL 952
Query: 339 -GRAGTRSTAHTNITVDRLEPGCLYVFSVWV----GKNGINSSRETRNATTAPNPVRNLH 393
A T +T+ L+P Y V G + S + R +N H
Sbjct: 953 LPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFH 1012
Query: 394 METQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTF 453
++ +S+ L WE+P+ Y + + Y DG E + T L+P Y+F
Sbjct: 1013 VKAVMKTSVLLSWEIPEN-YNSAMPFKILY-DDGKMVEEVDGRATQKLIVNLKPEKSYSF 1070
Query: 454 SVWAEKNGARGSRQNVSISTVPNAV 478
+ N A G + V+ T P+ +
Sbjct: 1071 VLTNRGNSAGGLQHRVTAKTAPDVL 1095
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/217 (23%), Positives = 88/217 (40%), Gaps = 15/217 (6%)
Query: 123 RNLRVEAQTNSSIALTWEVPDGPDPQN--STYGVEYTGDG----GRAGTRSTAHTNITVD 176
+NL E T++S+ L+W+ P + + Y + Y A T +T+
Sbjct: 910 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT 969
Query: 177 GLEPGCLYAFSMWV----GKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPD 232
GL+P Y + G + S + R +N V+A +S+ LSWE+P+
Sbjct: 970 GLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1029
Query: 233 GTDPQNSTYCVQCTGDGGR-TETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIV 291
NS + D G+ E + T+ + L P Y+ + + V
Sbjct: 1030 N---YNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRV 1086
Query: 292 TSATAPNPVRNL-TVEAQTNSSIALTWEVPDGPDPQN 327
T+ TAP+ +R +TN +T ++P+ P +N
Sbjct: 1087 TAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 1123
Score = 34.7 bits (78), Expect = 0.52
Identities = 45/190 (23%), Positives = 76/190 (40%), Gaps = 14/190 (7%)
Query: 34 RNLTVETQTTSSISLSWEVP-----DGLDSQNSNYWVQCTGDGGTTETRNTTA-TNVTVD 87
+NL E T++S+ LSW+ P +G+ ++ + + E A T +T+
Sbjct: 910 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT 969
Query: 88 GLGPGSLYTCSVWVEKD-GVNSSVGTVTTATAPNP---VRNLRVEAQTNSSIALTWEVPD 143
GL P + Y V G +V T P +N V+A +S+ L+WE+P+
Sbjct: 970 GLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1029
Query: 144 GPDPQNSTYGVEYTGDGGRAGTRSTAH-TNITVDGLEPGCLYAFSMWVGKNGINSSRETR 202
NS + D G+ T + L+P Y+F + N +
Sbjct: 1030 N---YNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRV 1086
Query: 203 NATTAHNPVR 212
A TA + +R
Sbjct: 1087 TAKTAPDVLR 1096
Score = 34.7 bits (78), Expect = 0.52
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 3/117 (2%)
Query: 34 RNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGS 93
+N V+ +S+ LSWE+P+ +S + + DG E + AT + L P
Sbjct: 1009 KNFHVKAVMKTSVLLSWEIPENYNS--AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEK 1066
Query: 94 LYTCSVWVEKDGVNSSVGTVTTATAPNPVRNL-RVEAQTNSSIALTWEVPDGPDPQN 149
Y+ + + VT TAP+ +R +TN +T ++P+ P +N
Sbjct: 1067 SYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 1123
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 236 bits (602), Expect = 9e-62
Identities = 128/345 (37%), Positives = 189/345 (54%), Gaps = 26/345 (7%)
Query: 755 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP-----------------ELRDLVFSSP 797
+ G + ++ + +V ++ + ++R + +K ELR L F +P
Sbjct: 1261 VVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP 1320
Query: 798 G-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRN 852
G IP + ADH+ + + + N F+ +Y+ + G + ++ N KNRY N
Sbjct: 1321 GMASHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYAN 1379
Query: 853 VLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQS 912
V+ YD SRV L I PGSDY+NA+++ G +IATQG LP+T GDFWR++WEQ+S
Sbjct: 1380 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1439
Query: 913 HTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK 972
T+VM+T E RVKC+ YWP THG ++VTL+ + + VR L + +
Sbjct: 1440 ATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRTFALYKNGSSE 1498
Query: 973 TLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIA 1032
VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG I
Sbjct: 1499 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTGCFIV 1556
Query: 1033 LDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
+D +L +++ E + + V MR R MVQTE QY+F+H +L
Sbjct: 1557 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1601
Score = 199 bits (507), Expect = 9e-51
Identities = 107/287 (37%), Positives = 167/287 (58%), Gaps = 6/287 (2%)
Query: 799 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 853
++PA + +++K + ++ G ++++L S H+ + A+ N KNR N+
Sbjct: 1610 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1669
Query: 854 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 913
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL +T DFWR++WE S
Sbjct: 1670 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1729
Query: 914 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 973
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1730 IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1788
Query: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
+VRQF + WP+ GVP S + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1789 RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITL 1848
Query: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
++L +++ EG++ F V+ +R RP MVQTE QY F ++ L +L
Sbjct: 1849 SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1895
Score = 91.7 bits (226), Expect = 4e-18
Identities = 175/786 (22%), Positives = 301/786 (38%), Gaps = 80/786 (10%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGT---TETRNTTATNVTV 86
P P V T +SI+L+W+ G S Y +Q E T +V
Sbjct: 323 PKPPGTPVVTESTATSITLTWD--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSV 380
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPV-RNLRVEAQTNSSIALTWEV 141
GL P S Y V + + + V T T+ AP+ R+++ ++++I + W+
Sbjct: 381 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDGLEPGCLYAFSMW----VGK 192
P+ P+ Q Y V YT D + H T+ L P Y+ + +G
Sbjct: 441 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 500
Query: 193 NGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRT 252
++S + T N + E ++ +SI LSW P +D + V G+ G
Sbjct: 501 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSW-TPPRSDTIANYELVYKDGEHGE- 558
Query: 253 ETRNTTD--TRVTVDGLGPGSLYTCSVWVEK-DGVNSSVEIVTSATAPN----PVRNLTV 305
E R T + T + GL P SLY + G+ +S +++ T + P ++++
Sbjct: 559 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 618
Query: 306 EAQTNSSIALTWEVPDGPDPQN---STYGVEYTGDGGR-------AGTRSTAHTNITVDR 355
+ +++SI ++W+ P + QN + Y ++YT G G S T +++
Sbjct: 619 TSPSSTSILVSWQ-PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDT-TKYLLEQ 676
Query: 356 LEPGCLYVFSVW----VGKNGINSSRETRNATTAPN-PVRNLHMETQTNSSIALCWE--V 408
LE Y +V VG + S R P+ P R + +E ++S+ + W V
Sbjct: 677 LEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPV 736
Query: 409 PDGPYPQDYTYWVEYTG-DGGGTETRNTTNTSVTAER-------LEPGTLYTFSVWAEKN 460
P+ + Q Y V Y + G + + + A+ L+P T Y+ +V A
Sbjct: 737 PNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTT 796
Query: 461 GARGSRQNVSISTVPNAVTS---LSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGM 517
G+R + + AV L +T ++W P Y + + R+ M
Sbjct: 797 KGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDM 856
Query: 518 TDPRTQSTSGTD--ITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEV-----TD 570
T S + T ++ G+ Y + A RN+V + + P EV +
Sbjct: 857 EPLTTLEFSEKEDHFTATDIHKGASYVFRLSA-RNKVGFGEEMVKEISIPEEVPTGFPQN 915
Query: 571 LQNETQTKNSVMLWWKAP--GDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNET 628
L +E T SV L W+ P + + + Y + + P + Q +T
Sbjct: 916 LHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME-------QLIVPADT 968
Query: 629 WYKVEALEPGTLYNFTVWAERN-DVASSTQSLCASTYP-DTVTITSC-VSTSAGYGVNLI 685
+ L+P T Y+ V A + + S+ T P D V + V V L
Sbjct: 969 TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLS 1028
Query: 686 WSCPQGGYEAFELEVGGQRGSQDRSSCGEAVS--VLGLGPARSYPATITTIWDGMKVVSH 743
W P+ A ++ G G A ++ L P +SY +T + + H
Sbjct: 1029 WEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQH 1088
Query: 744 SVVCHT 749
V T
Sbjct: 1089 RVTAKT 1094
Score = 90.1 bits (222), Expect = 1e-17
Identities = 134/562 (23%), Positives = 223/562 (39%), Gaps = 58/562 (10%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + GV ++ +T P P V T +SI LTW+ P+P S Y +
Sbjct: 300 YTC-VAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPV-SYYII 356
Query: 155 EYTGDGGRAGTRS---TAHTNITVDGLEPGCLYAFSMWVGKNGINS---SRETRNATTAH 208
++ + A T +V GL P Y F + V N I S T+
Sbjct: 357 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRV-VAVNNIGRGPPSEPVLTQTSEQ 415
Query: 209 NPV---RNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETR----NTTDTR 261
P R+++ ++++I + W+ P+ + Q Y V T D + N D++
Sbjct: 416 APSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 475
Query: 262 VTVDG-LGPGSLYTCSVWVEK---DG-VNSSVEIVTSATAPNPVRNLTVEAQTNSSIALT 316
+T G L P Y+ V DG ++S ++++T P N E ++ +SI L+
Sbjct: 476 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS 535
Query: 317 WEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH--TNITVDRLEPGCLYVFSVWV-GKNGI 373
W P N Y + Y R T T+ + L+P LY F + G+
Sbjct: 536 WTPPRSDTIAN--YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGL 593
Query: 374 NSSRETRNATTAPN----PVRNLHMETQTNSSIALCWEVPDGPYPQDY--TYWVEYTGDG 427
+S +A T + P +++ + +++SI + W+ P Y ++YT
Sbjct: 594 GASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVD 653
Query: 428 GGTETRN------TTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQ-NVSIST---VPNA 477
G + + + T E+LE T Y +V A + G +V I T VP+
Sbjct: 654 GEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSG 713
Query: 478 VTSLSKQDWTNST-IALRWTAPQGPGQSSY--SYWVSWVREGMTDPRTQS-------TSG 527
+ + NST + + W +P Q Y V +VR +P+ Q
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 528 TDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAATAPNEVTDLQNETQTKNSVML 583
D+ + L+ + Y LTV A + G S T P + + N TQ N+ ++
Sbjct: 774 QDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQ-MNTALI 832
Query: 584 WWKAPGDPHSQLYVYWVQWASK 605
W P D L Y +++ K
Sbjct: 833 QWHPPVDTFGPLQGYRLKFGRK 854
Score = 55.8 bits (133), Expect = 2e-07
Identities = 106/496 (21%), Positives = 191/496 (38%), Gaps = 57/496 (11%)
Query: 32 PGRNLTVETQTTSSISLSWEVPDGLDSQN---SNYWVQCTGDGGTTETRN------TTAT 82
P ++++ + +++SI +SW+ P ++ QN + Y ++ T G + + + T
Sbjct: 612 PPQDISCTSPSSTSILVSWQPPP-VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTT 670
Query: 83 NVTVDGLGPGSLYTCSVWVEKD---GVNS-SVGTVTTATAPN-PVRNLRVEAQTNSSIAL 137
++ L + Y +V D G S SV T P+ P R + VEA ++S+ +
Sbjct: 671 KYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKV 730
Query: 138 TWE--VPDGPDPQNSTYGVEYT--------GDGGRAGTRSTAHTNITVDGLEPGCLYAFS 187
+W VP+ Q Y V Y G ++ + GL+P Y+ +
Sbjct: 731 SWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLT 790
Query: 188 M--WVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISL-SWEVPDGTDPQNSTYCVQ 244
+ + K S+ +TT P + V T + +L W P T Y ++
Sbjct: 791 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLK 850
Query: 245 CTGDGGRTETRNTT-------DTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAP 297
GR + T + T + G+ Y + ++ V E+V + P
Sbjct: 851 F----GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA-RNKVGFGEEMVKEISIP 905
Query: 298 NPV-----RNLTVEAQTNSSIALTWEVPDGPDPQN--STYGVEYTGDG----GRAGTRST 346
V +NL E T++S+ L+W+ P + + Y + Y
Sbjct: 906 EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVP 965
Query: 347 AHTNITVDRLEPGCLYVFSVWV----GKNGINSSRETRNATTAPNPVRNLHMETQTNSSI 402
A T +T+ L+P Y V G + S + R +N H++ +S+
Sbjct: 966 ADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSV 1025
Query: 403 ALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGA 462
L WE+P+ Y + + Y DG E + T L+P Y+F + N A
Sbjct: 1026 LLSWEIPEN-YNSAMPFKILY-DDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSA 1083
Query: 463 RGSRQNVSISTVPNAV 478
G + V+ T P+ +
Sbjct: 1084 GGLQHRVTAKTAPDVL 1099
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/217 (23%), Positives = 88/217 (40%), Gaps = 15/217 (6%)
Query: 123 RNLRVEAQTNSSIALTWEVPDGPDPQN--STYGVEYTGDG----GRAGTRSTAHTNITVD 176
+NL E T++S+ L+W+ P + + Y + Y A T +T+
Sbjct: 914 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT 973
Query: 177 GLEPGCLYAFSMWV----GKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPD 232
GL+P Y + G + S + R +N V+A +S+ LSWE+P+
Sbjct: 974 GLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1033
Query: 233 GTDPQNSTYCVQCTGDGGR-TETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIV 291
NS + D G+ E + T+ + L P Y+ + + V
Sbjct: 1034 N---YNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRV 1090
Query: 292 TSATAPNPVRNL-TVEAQTNSSIALTWEVPDGPDPQN 327
T+ TAP+ +R +TN +T ++P+ P +N
Sbjct: 1091 TAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 1127
Score = 34.7 bits (78), Expect = 0.52
Identities = 45/190 (23%), Positives = 76/190 (40%), Gaps = 14/190 (7%)
Query: 34 RNLTVETQTTSSISLSWEVP-----DGLDSQNSNYWVQCTGDGGTTETRNTTA-TNVTVD 87
+NL E T++S+ LSW+ P +G+ ++ + + E A T +T+
Sbjct: 914 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT 973
Query: 88 GLGPGSLYTCSVWVEKD-GVNSSVGTVTTATAPNP---VRNLRVEAQTNSSIALTWEVPD 143
GL P + Y V G +V T P +N V+A +S+ L+WE+P+
Sbjct: 974 GLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1033
Query: 144 GPDPQNSTYGVEYTGDGGRAGTRSTAH-TNITVDGLEPGCLYAFSMWVGKNGINSSRETR 202
NS + D G+ T + L+P Y+F + N +
Sbjct: 1034 N---YNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRV 1090
Query: 203 NATTAHNPVR 212
A TA + +R
Sbjct: 1091 TAKTAPDVLR 1100
Score = 34.7 bits (78), Expect = 0.52
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 3/117 (2%)
Query: 34 RNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGS 93
+N V+ +S+ LSWE+P+ +S + + DG E + AT + L P
Sbjct: 1013 KNFHVKAVMKTSVLLSWEIPENYNS--AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEK 1070
Query: 94 LYTCSVWVEKDGVNSSVGTVTTATAPNPVRNL-RVEAQTNSSIALTWEVPDGPDPQN 149
Y+ + + VT TAP+ +R +TN +T ++P+ P +N
Sbjct: 1071 SYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 1127
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 236 bits (602), Expect = 9e-62
Identities = 128/345 (37%), Positives = 189/345 (54%), Gaps = 26/345 (7%)
Query: 755 IAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP-----------------ELRDLVFSSP 797
+ G + ++ + +V ++ + ++R + +K ELR L F +P
Sbjct: 859 VVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP 918
Query: 798 G-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRN 852
G IP + ADH+ + + + N F+ +Y+ + G + ++ N KNRY N
Sbjct: 919 GMASHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYAN 977
Query: 853 VLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQS 912
V+ YD SRV L I PGSDY+NA+++ G +IATQG LP+T GDFWR++WEQ+S
Sbjct: 978 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1037
Query: 913 HTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK 972
T+VM+T E RVKC+ YWP THG ++VTL+ + + VR L + +
Sbjct: 1038 ATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRTFALYKNGSSE 1096
Query: 973 TLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIA 1032
VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG I
Sbjct: 1097 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTGCFIV 1154
Query: 1033 LDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
+D +L +++ E + + V MR R MVQTE QY+F+H +L
Sbjct: 1155 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1199
Score = 199 bits (507), Expect = 9e-51
Identities = 107/287 (37%), Positives = 167/287 (58%), Gaps = 6/287 (2%)
Query: 799 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 853
++PA + +++K + ++ G ++++L S H+ + A+ N KNR N+
Sbjct: 1208 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1267
Query: 854 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 913
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL +T DFWR++WE S
Sbjct: 1268 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1327
Query: 914 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 973
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1328 IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1386
Query: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
+VRQF + WP+ GVP S + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1387 RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITL 1446
Query: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
++L +++ EG++ F V+ +R RP MVQTE QY F ++ L +L
Sbjct: 1447 SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1493
Score = 86.7 bits (213), Expect = 1e-16
Identities = 101/406 (24%), Positives = 167/406 (41%), Gaps = 30/406 (7%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + GV ++ +T P P V T +SI LTW+ P+P S Y +
Sbjct: 300 YTC-VAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPV-SYYII 356
Query: 155 EYTGDGGRAGTRS---TAHTNITVDGLEPGCLYAFSMWVGKNGINS---SRETRNATTAH 208
++ + A T +V GL P Y F + V N I S T+
Sbjct: 357 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRV-VAVNNIGRGPPSEPVLTQTSEQ 415
Query: 209 NPV---RNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETR----NTTDTR 261
P R+++ ++++I + W+ P+ + Q Y V T D + N D++
Sbjct: 416 APSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 475
Query: 262 VTVDG-LGPGSLYTCSVWVEK---DG-VNSSVEIVTSATAPNPVRNLTVEAQTNSSIALT 316
+T G L P Y+ V DG ++S ++++T P N E ++ +SI L+
Sbjct: 476 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS 535
Query: 317 WEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH--TNITVDRLEPGCLYVFSVWV-GKNGI 373
W P N Y + Y R T T+ + L+P LY F + G+
Sbjct: 536 WTPPRSDTIAN--YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGL 593
Query: 374 NSSRETRNATTAPNP-VRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTET 432
+S +A T + +N H++ +S+ L WE+P+ Y + + Y DG E
Sbjct: 594 GASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN-YNSAMPFKILY-DDGKMVEE 651
Query: 433 RNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAV 478
+ T L+P Y+F + N A G + V+ T P+ +
Sbjct: 652 VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVL 697
Score = 72.8 bits (177), Expect = 2e-12
Identities = 93/383 (24%), Positives = 154/383 (40%), Gaps = 29/383 (7%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGT---TETRNTTATNVTV 86
P P V T +SI+L+W+ G S Y +Q E T +V
Sbjct: 323 PKPPGTPVVTESTATSITLTWD--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSV 380
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPV-RNLRVEAQTNSSIALTWEV 141
GL P S Y V + + + V T T+ AP+ R+++ ++++I + W+
Sbjct: 381 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDGLEPGCLYAFSMW----VGK 192
P+ P+ Q Y V YT D + H T+ L P Y+ + +G
Sbjct: 441 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 500
Query: 193 NGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRT 252
++S + T N + E ++ +SI LSW P +D + V G+ G
Sbjct: 501 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSW-TPPRSDTIANYELVYKDGEHGE- 558
Query: 253 ETRNTTD--TRVTVDGLGPGSLYTCSVWVEK-DGVNSSVEIVTSATAPNP-VRNLTVEAQ 308
E R T + T + GL P SLY + G+ +S +++ T + +N V+A
Sbjct: 559 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAV 618
Query: 309 TNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH-TNITVDRLEPGCLYVFSVW 367
+S+ L+WE+P+ NS + D G+ T + L+P Y F +
Sbjct: 619 MKTSVLLSWEIPEN---YNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLT 675
Query: 368 VGKNGINSSRETRNATTAPNPVR 390
N + A TAP+ +R
Sbjct: 676 NRGNSAGGLQHRVTAKTAPDVLR 698
Score = 55.1 bits (131), Expect = 4e-07
Identities = 79/390 (20%), Positives = 136/390 (34%), Gaps = 46/390 (11%)
Query: 386 PNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGT---ETRNTTNTSVTA 442
P P + T +SI L W+ P P Y Y +++ E T +
Sbjct: 323 PKPPGTPVVTESTATSITLTWD-SGNPEPVSY-YIIQHKPKNSEELYKEIDGVATTRYSV 380
Query: 443 ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQD-----WTNSTIALRWTA 497
L P + Y F V A N RG ++ S + +D +++TI ++W
Sbjct: 381 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 440
Query: 498 PQGPGQSSYSYWV-----------SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 546
P+ P Y V +W++ + D + T+ L Y + V
Sbjct: 441 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT-------TIGNLVPQKTYSVKVL 493
Query: 547 AERNEVRGYNST----LTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 602
A + G S+ +T P + + + E +++ S++L W P Y +
Sbjct: 494 AFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
Query: 603 ASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAER-NDVASSTQSLCA 661
G +R + T Y+++ L+P +LY F + A + +ST + A
Sbjct: 554 GEHGEEQR-----------ITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISA 602
Query: 662 STYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVS--VL 719
T V V L W P+ A ++ G G A ++
Sbjct: 603 RTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 662
Query: 720 GLGPARSYPATITTIWDGMKVVSHSVVCHT 749
L P +SY +T + + H V T
Sbjct: 663 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 692
Score = 34.7 bits (78), Expect = 0.52
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 3/117 (2%)
Query: 34 RNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGS 93
+N V+ +S+ LSWE+P+ +S + + DG E + AT + L P
Sbjct: 611 KNFHVKAVMKTSVLLSWEIPENYNS--AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEK 668
Query: 94 LYTCSVWVEKDGVNSSVGTVTTATAPNPVRNL-RVEAQTNSSIALTWEVPDGPDPQN 149
Y+ + + VT TAP+ +R +TN +T ++P+ P +N
Sbjct: 669 SYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 725
Score = 30.8 bits (68), Expect = 7.5
Identities = 31/142 (21%), Positives = 60/142 (42%), Gaps = 11/142 (7%)
Query: 469 VSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSG- 527
+++ +P + + T ++I L W + SY++ + ++ + G
Sbjct: 317 ITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYIIQHKPKNSEELYKEIDGV 373
Query: 528 --TDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAATAPNEVT-DLQNETQTKNS 580
T ++ L S Y V A N RG S T T+ AP+ D+Q + +
Sbjct: 374 ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT 433
Query: 581 VMLWWKAPGDPHSQLYVYWVQW 602
+++ WK P +P+ Q+ Y V +
Sbjct: 434 ILVQWKEPEEPNGQIQGYRVYY 455
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 235 bits (599), Expect = 2e-61
Identities = 124/295 (42%), Positives = 172/295 (58%), Gaps = 9/295 (3%)
Query: 788 ELRDLVFSSPG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASAS 842
ELR L F +PG IP + ADH+ + + + N F+ +Y+ + G + ++
Sbjct: 910 ELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLE 968
Query: 843 ENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGD 902
N KNRY NV+ YD SRV L I PGSDY+NA+++ G +IATQG LP+T GD
Sbjct: 969 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGD 1028
Query: 903 FWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRE 962
FWR++WEQ+S T+VM+T E RVKC+ YWP THG ++VTL+ + + VR
Sbjct: 1029 FWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRT 1087
Query: 963 LLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSA 1022
L + + VRQF + AWPDHGVP P LAF R ++ + GP +VHCSA
Sbjct: 1088 FALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSA 1145
Query: 1023 GVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
GVGRTG I +D +L +++ E + + V MR R MVQTE QY+F+H +L
Sbjct: 1146 GVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1200
Score = 199 bits (507), Expect = 9e-51
Identities = 107/287 (37%), Positives = 167/287 (58%), Gaps = 6/287 (2%)
Query: 799 DIPAEDFADHVRKNER----DSNCGFADKYQQL-SLVGHSQSQMVASASENNAKNRYRNV 853
++PA + +++K + ++ G ++++L S H+ + A+ N KNR N+
Sbjct: 1209 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1268
Query: 854 LPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 913
+PY+ +RV L+PI GSDYINASF+ G + +IATQGPL +T DFWR++WE S
Sbjct: 1269 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1328
Query: 914 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 973
+VMLT E GR KC YWP + + + + V + E M + +RE + + ++
Sbjct: 1329 IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS 1387
Query: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
+VRQF + WP+ GVP S + + F + + +Q + GP VHCSAGVGRTG I L
Sbjct: 1388 RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITL 1447
Query: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
++L +++ EG++ F V+ +R RP MVQTE QY F ++ L +L
Sbjct: 1448 SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1494
Score = 86.7 bits (213), Expect = 1e-16
Identities = 101/406 (24%), Positives = 167/406 (41%), Gaps = 30/406 (7%)
Query: 95 YTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGV 154
YTC V + GV ++ +T P P V T +SI LTW+ P+P S Y +
Sbjct: 297 YTC-VAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPV-SYYII 353
Query: 155 EYTGDGGRAGTRS---TAHTNITVDGLEPGCLYAFSMWVGKNGINS---SRETRNATTAH 208
++ + A T +V GL P Y F + V N I S T+
Sbjct: 354 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRV-VAVNNIGRGPPSEPVLTQTSEQ 412
Query: 209 NPV---RNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETR----NTTDTR 261
P R+++ ++++I + W+ P+ + Q Y V T D + N D++
Sbjct: 413 APSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 472
Query: 262 VTVDG-LGPGSLYTCSVWVEK---DG-VNSSVEIVTSATAPNPVRNLTVEAQTNSSIALT 316
+T G L P Y+ V DG ++S ++++T P N E ++ +SI L+
Sbjct: 473 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS 532
Query: 317 WEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH--TNITVDRLEPGCLYVFSVWV-GKNGI 373
W P N Y + Y R T T+ + L+P LY F + G+
Sbjct: 533 WTPPRSDTIAN--YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGL 590
Query: 374 NSSRETRNATTAPNP-VRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTET 432
+S +A T + +N H++ +S+ L WE+P+ Y + + Y DG E
Sbjct: 591 GASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN-YNSAMPFKILY-DDGKMVEE 648
Query: 433 RNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAV 478
+ T L+P Y+F + N A G + V+ T P+ +
Sbjct: 649 VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVL 694
Score = 72.8 bits (177), Expect = 2e-12
Identities = 93/383 (24%), Positives = 154/383 (40%), Gaps = 29/383 (7%)
Query: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGT---TETRNTTATNVTV 86
P P V T +SI+L+W+ G S Y +Q E T +V
Sbjct: 320 PKPPGTPVVTESTATSITLTWD--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSV 377
Query: 87 DGLGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPV-RNLRVEAQTNSSIALTWEV 141
GL P S Y V + + + V T T+ AP+ R+++ ++++I + W+
Sbjct: 378 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 437
Query: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDGLEPGCLYAFSMW----VGK 192
P+ P+ Q Y V YT D + H T+ L P Y+ + +G
Sbjct: 438 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 497
Query: 193 NGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRT 252
++S + T N + E ++ +SI LSW P +D + V G+ G
Sbjct: 498 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSW-TPPRSDTIANYELVYKDGEHGE- 555
Query: 253 ETRNTTD--TRVTVDGLGPGSLYTCSVWVEK-DGVNSSVEIVTSATAPNP-VRNLTVEAQ 308
E R T + T + GL P SLY + G+ +S +++ T + +N V+A
Sbjct: 556 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAV 615
Query: 309 TNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH-TNITVDRLEPGCLYVFSVW 367
+S+ L+WE+P+ NS + D G+ T + L+P Y F +
Sbjct: 616 MKTSVLLSWEIPEN---YNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLT 672
Query: 368 VGKNGINSSRETRNATTAPNPVR 390
N + A TAP+ +R
Sbjct: 673 NRGNSAGGLQHRVTAKTAPDVLR 695
Score = 55.1 bits (131), Expect = 4e-07
Identities = 79/390 (20%), Positives = 136/390 (34%), Gaps = 46/390 (11%)
Query: 386 PNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGT---ETRNTTNTSVTA 442
P P + T +SI L W+ P P Y Y +++ E T +
Sbjct: 320 PKPPGTPVVTESTATSITLTWD-SGNPEPVSY-YIIQHKPKNSEELYKEIDGVATTRYSV 377
Query: 443 ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQD-----WTNSTIALRWTA 497
L P + Y F V A N RG ++ S + +D +++TI ++W
Sbjct: 378 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 437
Query: 498 PQGPGQSSYSYWV-----------SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 546
P+ P Y V +W++ + D + T+ L Y + V
Sbjct: 438 PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT-------TIGNLVPQKTYSVKVL 490
Query: 547 AERNEVRGYNST----LTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 602
A + G S+ +T P + + + E +++ S++L W P Y +
Sbjct: 491 AFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKD 550
Query: 603 ASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAER-NDVASSTQSLCA 661
G +R + T Y+++ L+P +LY F + A + +ST + A
Sbjct: 551 GEHGEEQR-----------ITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISA 599
Query: 662 STYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVS--VL 719
T V V L W P+ A ++ G G A ++
Sbjct: 600 RTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 659
Query: 720 GLGPARSYPATITTIWDGMKVVSHSVVCHT 749
L P +SY +T + + H V T
Sbjct: 660 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 689
Score = 34.7 bits (78), Expect = 0.52
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 3/117 (2%)
Query: 34 RNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGS 93
+N V+ +S+ LSWE+P+ +S + + DG E + AT + L P
Sbjct: 608 KNFHVKAVMKTSVLLSWEIPENYNS--AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEK 665
Query: 94 LYTCSVWVEKDGVNSSVGTVTTATAPNPVRNL-RVEAQTNSSIALTWEVPDGPDPQN 149
Y+ + + VT TAP+ +R +TN +T ++P+ P +N
Sbjct: 666 SYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 722
Score = 30.8 bits (68), Expect = 7.5
Identities = 31/142 (21%), Positives = 60/142 (42%), Gaps = 11/142 (7%)
Query: 469 VSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSG- 527
+++ +P + + T ++I L W + SY++ + ++ + G
Sbjct: 314 ITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYIIQHKPKNSEELYKEIDGV 370
Query: 528 --TDITLKELEAGSLYHLTVWAERNEVRGYNS----TLTAATAPNEVT-DLQNETQTKNS 580
T ++ L S Y V A N RG S T T+ AP+ D+Q + +
Sbjct: 371 ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT 430
Query: 581 VMLWWKAPGDPHSQLYVYWVQW 602
+++ WK P +P+ Q+ Y V +
Sbjct: 431 ILVQWKEPEEPNGQIQGYRVYY 452
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 232 bits (592), Expect = 1e-60
Identities = 116/278 (41%), Positives = 171/278 (61%), Gaps = 5/278 (1%)
Query: 800 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859
I D H+ + +R GF ++Y+ L G + S A EN KNRY N++ YD S
Sbjct: 869 IRVADLLQHITQMKRGQGYGFKEEYEALP-EGQTASWDTAKEDENRNKNRYGNIISYDHS 927
Query: 860 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 919
RV L + +P SDYINA+++ G P+ +IATQGP+ +TV DFWR++W++ S ++VM+T
Sbjct: 928 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 987
Query: 920 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 979
N +E GRVKC YWP D++ +G ++VTL+ E + + +R + + + +R F
Sbjct: 988 NLVEVGRVKCVRYWPDDTE--VYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1045
Query: 980 HYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQ 1039
H+ +WPDHGVP LL F R ++ E GP +VHCSAG GRTG IA+D +L
Sbjct: 1046 HFTSWPDHGVPCYATGLLGFVRQVK--FLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1103
Query: 1040 LQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
++EG++ F+ VR++R R +VQTE QYVF+H IL
Sbjct: 1104 AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL 1141
Score = 123 bits (308), Expect = 1e-27
Identities = 85/278 (30%), Positives = 139/278 (50%), Gaps = 11/278 (3%)
Query: 810 RKNERDSNCGFADKYQQLSLVG---HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPI 866
R + + ++ D++Q L++V + + N+ KNR +VLP D L +
Sbjct: 1165 RLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISV 1224
Query: 867 HEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGR 926
E S+YINA+ M P F+ TQ PLP TV DFWRLV++ ++VML N M+ +
Sbjct: 1225 DGE-SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVML-NEMDTAQ 1282
Query: 927 VKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT--LSVRQFHYQAW 984
C YWP + C +G ++V V ++ E+ R + + + V+ Y W
Sbjct: 1283 F-CMQYWPEKTSGC-YGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGW 1340
Query: 985 PDH-GVPSSPDTLLAFWRMLRQWLDQ-TMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQS 1042
P + P S +LL R L +W +Q G +VHC G GR+GT A+ + +Q
Sbjct: 1341 PAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQ 1400
Query: 1043 EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
+ ++ F V+ +R ++ MV+T QY F+++ L +L
Sbjct: 1401 QNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL 1438
Score = 35.8 bits (81), Expect = 0.23
Identities = 20/74 (27%), Positives = 36/74 (48%), Gaps = 8/74 (10%)
Query: 578 KNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRT----NETWYKVE 633
+ + + WK P + + + +Y + + + G DP A+ +Q + NET +
Sbjct: 499 EEKIYIQWKPPNETNGVITLYEINYKAVG----SLDPSADLSSQRGKVFKLRNETHHLFV 554
Query: 634 ALEPGTLYNFTVWA 647
L PGT Y+FT+ A
Sbjct: 555 GLYPGTTYSFTIKA 568
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 232 bits (592), Expect = 1e-60
Identities = 116/278 (41%), Positives = 171/278 (61%), Gaps = 5/278 (1%)
Query: 800 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859
I D H+ + +R GF ++Y+ L G + S A EN KNRY N++ YD S
Sbjct: 888 IRVADLLQHITQMKRGQGYGFKEEYEALP-EGQTASWDTAKEDENRNKNRYGNIISYDHS 946
Query: 860 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 919
RV L + +P SDYINA+++ G P+ +IATQGP+ +TV DFWR++W++ S ++VM+T
Sbjct: 947 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 1006
Query: 920 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 979
N +E GRVKC YWP D++ +G ++VTL+ E + + +R + + + +R F
Sbjct: 1007 NLVEVGRVKCVRYWPDDTE--VYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1064
Query: 980 HYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQ 1039
H+ +WPDHGVP LL F R ++ E GP +VHCSAG GRTG IA+D +L
Sbjct: 1065 HFTSWPDHGVPCYATGLLGFVRQVK--FLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1122
Query: 1040 LQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
++EG++ F+ VR++R R +VQTE QYVF+H IL
Sbjct: 1123 AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL 1160
Score = 123 bits (308), Expect = 1e-27
Identities = 85/278 (30%), Positives = 139/278 (50%), Gaps = 11/278 (3%)
Query: 810 RKNERDSNCGFADKYQQLSLVG---HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPI 866
R + + ++ D++Q L++V + + N+ KNR +VLP D L +
Sbjct: 1184 RLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISV 1243
Query: 867 HEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGR 926
E S+YINA+ M P F+ TQ PLP TV DFWRLV++ ++VML N M+ +
Sbjct: 1244 DGE-SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVML-NEMDTAQ 1301
Query: 927 VKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT--LSVRQFHYQAW 984
C YWP + C +G ++V V ++ E+ R + + + V+ Y W
Sbjct: 1302 F-CMQYWPEKTSGC-YGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGW 1359
Query: 985 PDH-GVPSSPDTLLAFWRMLRQWLDQ-TMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQS 1042
P + P S +LL R L +W +Q G +VHC G GR+GT A+ + +Q
Sbjct: 1360 PAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQ 1419
Query: 1043 EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
+ ++ F V+ +R ++ MV+T QY F+++ L +L
Sbjct: 1420 QNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL 1457
Score = 35.8 bits (81), Expect = 0.23
Identities = 20/74 (27%), Positives = 36/74 (48%), Gaps = 8/74 (10%)
Query: 578 KNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRT----NETWYKVE 633
+ + + WK P + + + +Y + + + G DP A+ +Q + NET +
Sbjct: 499 EEKIYIQWKPPNETNGVITLYEINYKAVG----SLDPSADLSSQRGKVFKLRNETHHLFV 554
Query: 634 ALEPGTLYNFTVWA 647
L PGT Y+FT+ A
Sbjct: 555 GLYPGTTYSFTIKA 568
Score = 30.4 bits (67), Expect = 9.8
Identities = 29/138 (21%), Positives = 60/138 (43%), Gaps = 10/138 (7%)
Query: 653 ASSTQSL---CASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFEL--EVGGQRGSQ 707
ASS SL A P + +T + N W+ P +++ + + + +
Sbjct: 655 ASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGE 714
Query: 708 DRSSCGEAVSVLGLGPARSYPAT-ITTIWDGMKVVSHSVV---CHTESAGVIAGAFVGIL 763
+ +C + +G A+ P T + + G + + V ++ +AG G+L
Sbjct: 715 TKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLL 774
Query: 764 LF-LILVGLLIFFLKRRN 780
+F +IL+G+++ +RRN
Sbjct: 775 MFIIILLGVMLTIKRRRN 792
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 232 bits (591), Expect = 2e-60
Identities = 129/349 (36%), Positives = 191/349 (54%), Gaps = 29/349 (8%)
Query: 754 VIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP--------------------ELRDLV 793
VI + + I++ +L++ K +K+K +P E+R +
Sbjct: 859 VIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRIN 918
Query: 794 FSSPG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKN 848
F +PG IP D A+H + + + + + +Y+ + G + ++ N KN
Sbjct: 919 FQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID-PGQQFTWEHSNLEVNKPKN 977
Query: 849 RYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVW 908
RY NV+ YD SRV L+PI GSDYINA+++ G +IATQGPLP+T GDFWR+VW
Sbjct: 978 RYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVW 1037
Query: 909 EQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQV 968
EQ+S T+VM+T E R+KC+ YWP + T+G ++VTL+ + + VR L +
Sbjct: 1038 EQRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKN 1096
Query: 969 EEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTG 1028
+ VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG
Sbjct: 1097 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTG 1154
Query: 1029 TLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
I +D +L +++ E + + V MR R MVQTE QY F+H+ +L
Sbjct: 1155 CFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL 1203
Score = 199 bits (505), Expect = 2e-50
Identities = 101/249 (40%), Positives = 148/249 (59%), Gaps = 1/249 (0%)
Query: 832 HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIA 891
H+ + A+ N KNR N++PY+ +RV L+PI GSDYINASF+ G + +IA
Sbjct: 1250 HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIA 1309
Query: 892 TQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVG 951
TQGPL +T DFWR++WE S +VMLT E GR KC YWP + + + + V +
Sbjct: 1310 TQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMA 1368
Query: 952 EEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTM 1011
E M + +RE + + ++ +VRQF + WP+ GVP S + + F + + +Q
Sbjct: 1369 EYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1428
Query: 1012 EGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVF 1071
+ GP VHCSAGVGRTG I L ++L +++ EG++ F V+ +R RP MVQTE +Y F
Sbjct: 1429 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1488
Query: 1072 LHQCILRFL 1080
+Q L +L
Sbjct: 1489 CYQAALEYL 1497
Score = 59.7 bits (143), Expect = 2e-08
Identities = 80/319 (25%), Positives = 129/319 (40%), Gaps = 25/319 (7%)
Query: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG----GTTETRN 78
TG +APA P RN+ + +++ + WE P + Y V T + G + N
Sbjct: 412 TGEQAPASAP-RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHN 470
Query: 79 TTATNVTVDG-LGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNS 133
+ +T G L YT V V ++ + T P NLR EA++ +
Sbjct: 471 VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET 530
Query: 134 SIALTWEVPDGPDPQNSTYGVEY---TGDGGR-AGTRSTAHTNITVDGLEPGCLYAFSMW 189
SI L+W P Q S E GD GR G T+ V+ L+P YAF +
Sbjct: 531 SITLSW----SPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLA 586
Query: 190 V-GKNGINS-SRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTG 247
G+ + + R T +N +V+ +S+ LSWE PD + + Y +Q
Sbjct: 587 ARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYN-SPTPYKIQY-- 643
Query: 248 DGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNL-TVE 306
G T + T+ + L P + Y + + + VT+ TA N + +V
Sbjct: 644 -NGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVA 702
Query: 307 AQTNSSIALTWEVPDGPDP 325
+ ++ + +PDG P
Sbjct: 703 PKPDADGFIMVYLPDGQSP 721
Score = 56.6 bits (135), Expect = 1e-07
Identities = 91/380 (23%), Positives = 137/380 (36%), Gaps = 46/380 (12%)
Query: 216 VEAQTTSSISLSWEVPDGTDPQNSTYCVQCTG---DGGRTETRNTTDTRVTVDGLGPGSL 272
V T +SI+++W+ G S Y ++ DG + T TR ++ GL P S
Sbjct: 331 VTENTATSITITWD--SGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 388
Query: 273 YTCSVWVEKDGVNS--------SVEIVTSATAP-NPVRNLTVEAQTNSSIALTWEVPDGP 323
Y +WV VNS SV T AP + RN+ + +++ + WE P P
Sbjct: 389 Y--EIWVS--AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEP 444
Query: 324 DPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDRLEPGCLYVFSVW----VGKNGIN 374
+ Y V YT + H TV L Y V VG ++
Sbjct: 445 NGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS 504
Query: 375 SSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRN 434
+ + P NL E ++ +SI L W P Y G
Sbjct: 505 DPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTF 564
Query: 435 TTNTSVTAERLEPGTLYTFSVWAEKNGARGS-----RQNVSISTVPNAVTSLSKQDWTNS 489
TS E L+P T Y F + A G+ RQ S P + + +
Sbjct: 565 DPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPK---NFKVKMIMKT 621
Query: 490 TIALRWTAPQGPGQSSYSYWVSWVREGMT---DPRTQSTSGTDITLKELEAGSLYHLTVW 546
++ L W P S Y + + G+T D RT T + L+ + Y+ +
Sbjct: 622 SVLLSWEFPDN-YNSPTPYKIQY--NGLTLDVDGRT-----TKKLITHLKPHTFYNFVLT 673
Query: 547 AERNEVRGYNSTLTAATAPN 566
+ + G T+TA TA N
Sbjct: 674 NRGSSLGGLQQTVTAWTAFN 693
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 232 bits (591), Expect = 2e-60
Identities = 129/349 (36%), Positives = 191/349 (54%), Gaps = 29/349 (8%)
Query: 754 VIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP--------------------ELRDLV 793
VI + + I++ +L++ K +K+K +P E+R +
Sbjct: 1264 VIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRIN 1323
Query: 794 FSSPG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKN 848
F +PG IP D A+H + + + + + +Y+ + G + ++ N KN
Sbjct: 1324 FQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID-PGQQFTWEHSNLEVNKPKN 1382
Query: 849 RYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVW 908
RY NV+ YD SRV L+PI GSDYINA+++ G +IATQGPLP+T GDFWR+VW
Sbjct: 1383 RYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVW 1442
Query: 909 EQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQV 968
EQ+S T+VM+T E R+KC+ YWP + T+G ++VTL+ + + VR L +
Sbjct: 1443 EQRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKN 1501
Query: 969 EEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTG 1028
+ VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG
Sbjct: 1502 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTG 1559
Query: 1029 TLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
I +D +L +++ E + + V MR R MVQTE QY F+H+ +L
Sbjct: 1560 CFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL 1608
Score = 199 bits (505), Expect = 2e-50
Identities = 101/249 (40%), Positives = 148/249 (59%), Gaps = 1/249 (0%)
Query: 832 HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIA 891
H+ + A+ N KNR N++PY+ +RV L+PI GSDYINASF+ G + +IA
Sbjct: 1655 HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIA 1714
Query: 892 TQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVG 951
TQGPL +T DFWR++WE S +VMLT E GR KC YWP + + + + V +
Sbjct: 1715 TQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMA 1773
Query: 952 EEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTM 1011
E M + +RE + + ++ +VRQF + WP+ GVP S + + F + + +Q
Sbjct: 1774 EYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1833
Query: 1012 EGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVF 1071
+ GP VHCSAGVGRTG I L ++L +++ EG++ F V+ +R RP MVQTE +Y F
Sbjct: 1834 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1893
Query: 1072 LHQCILRFL 1080
+Q L +L
Sbjct: 1894 CYQAALEYL 1902
Score = 59.7 bits (143), Expect = 2e-08
Identities = 150/713 (21%), Positives = 253/713 (35%), Gaps = 97/713 (13%)
Query: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG----GTTETRN 78
TG +APA P RN+ + +++ + WE P + Y V T + G + N
Sbjct: 408 TGEQAPASAP-RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHN 466
Query: 79 TTATNVTVDG-LGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNS 133
+ +T G L YT V V ++ + T P NLR EA++ +
Sbjct: 467 VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET 526
Query: 134 SIALTWEVPDGPDPQNSTYGVEY---TGDGGR-AGTRSTAHTNITVDGLEPGCLYAFSMW 189
SI L+W P Q S E GD GR G T+ V+ L+P YAF +
Sbjct: 527 SITLSW----SPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLA 582
Query: 190 V-GKNGINSSRETRNATTAHN----PVRNLRVEAQTTSSISLSWEVPDGTDPQNST--YC 242
G+ + T + P ++++ + +++I +SW P + Y
Sbjct: 583 ARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYS 642
Query: 243 VQCTGDGGRTETRN------TTDTRVTVDGLGPGSLYTCSVWVEKD---GVNSSVEIV-T 292
V+ G T T++ ++ L + Y + + G SS +V T
Sbjct: 643 VRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRT 702
Query: 293 SATAPN-PVRNLTVEAQTNSSIALTWEVPDGPDPQNST---YGVEYT---GDGGRAGTR- 344
P+ P R + EA ++I + W P P Q+ Y V Y G R R
Sbjct: 703 DEDVPSAPPRKVEAEALNATAIRVLWRSP-APGRQHGQIRGYQVHYVRMEGAEARGPPRI 761
Query: 345 ----STAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPV---RNLHMETQ 397
+ + L+P Y +V + +R V L ++
Sbjct: 762 KDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQT 821
Query: 398 TNSSIALCWEVPDG-PYPQDYTYWVEYTGDGG---GTETRNTTNTSVTAERLEPGTLYTF 453
S+ WE P G Q Y +++ + T + TA + G Y F
Sbjct: 822 PEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVF 881
Query: 454 SVWAEKNGARGSRQNVSISTVPNAVTSLSKQ------DWTNSTIALRWTAPQGPGQSS-- 505
+ A G G + + ++P Q + + T+ LRW P ++
Sbjct: 882 RLAARSRGGLG-EEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAI 940
Query: 506 YSYWVSWVREGMTDPRTQST--------SGTDITLKELEAGSLYHLTVWAERNEVRG--- 554
Y V+ G P ++ + +TL+ L+ + Y L V A G
Sbjct: 941 VKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFS 1000
Query: 555 ----YNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRR 610
Y + L +P + + + K SV+L W+ P D ++ Y +Q+
Sbjct: 1001 PPVRYRTFLRDQVSPK---NFKVKMIMKTSVLLSWEFP-DNYNSPTPYKIQY-------- 1048
Query: 611 GQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCAST 663
N + T + L+P T YNF + + + Q++ A T
Sbjct: 1049 ------NGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWT 1095
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 232 bits (591), Expect = 2e-60
Identities = 129/349 (36%), Positives = 191/349 (54%), Gaps = 29/349 (8%)
Query: 754 VIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP--------------------ELRDLV 793
VI + + I++ +L++ K +K+K +P E+R +
Sbjct: 855 VIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRIN 914
Query: 794 FSSPG-----DIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKN 848
F +PG IP D A+H + + + + + +Y+ + G + ++ N KN
Sbjct: 915 FQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID-PGQQFTWEHSNLEVNKPKN 973
Query: 849 RYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVW 908
RY NV+ YD SRV L+PI GSDYINA+++ G +IATQGPLP+T GDFWR+VW
Sbjct: 974 RYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVW 1033
Query: 909 EQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQV 968
EQ+S T+VM+T E R+KC+ YWP + T+G ++VTL+ + + VR L +
Sbjct: 1034 EQRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKN 1092
Query: 969 EEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTG 1028
+ VRQF + AWPDHGVP P LAF R ++ + GP +VHCSAGVGRTG
Sbjct: 1093 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTG 1150
Query: 1029 TLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
I +D +L +++ E + + V MR R MVQTE QY F+H+ +L
Sbjct: 1151 CFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL 1199
Score = 199 bits (505), Expect = 2e-50
Identities = 101/249 (40%), Positives = 148/249 (59%), Gaps = 1/249 (0%)
Query: 832 HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIA 891
H+ + A+ N KNR N++PY+ +RV L+PI GSDYINASF+ G + +IA
Sbjct: 1246 HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIA 1305
Query: 892 TQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVG 951
TQGPL +T DFWR++WE S +VMLT E GR KC YWP + + + + V +
Sbjct: 1306 TQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMA 1364
Query: 952 EEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTM 1011
E M + +RE + + ++ +VRQF + WP+ GVP S + + F + + +Q
Sbjct: 1365 EYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1424
Query: 1012 EGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVF 1071
+ GP VHCSAGVGRTG I L ++L +++ EG++ F V+ +R RP MVQTE +Y F
Sbjct: 1425 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1484
Query: 1072 LHQCILRFL 1080
+Q L +L
Sbjct: 1485 CYQAALEYL 1493
Score = 59.7 bits (143), Expect = 2e-08
Identities = 80/319 (25%), Positives = 129/319 (40%), Gaps = 25/319 (7%)
Query: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG----GTTETRN 78
TG +APA P RN+ + +++ + WE P + Y V T + G + N
Sbjct: 408 TGEQAPASAP-RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHN 466
Query: 79 TTATNVTVDG-LGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNS 133
+ +T G L YT V V ++ + T P NLR EA++ +
Sbjct: 467 VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET 526
Query: 134 SIALTWEVPDGPDPQNSTYGVEY---TGDGGR-AGTRSTAHTNITVDGLEPGCLYAFSMW 189
SI L+W P Q S E GD GR G T+ V+ L+P YAF +
Sbjct: 527 SITLSW----SPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLA 582
Query: 190 V-GKNGINS-SRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTG 247
G+ + + R T +N +V+ +S+ LSWE PD + + Y +Q
Sbjct: 583 ARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYN-SPTPYKIQY-- 639
Query: 248 DGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNL-TVE 306
G T + T+ + L P + Y + + + VT+ TA N + +V
Sbjct: 640 -NGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVA 698
Query: 307 AQTNSSIALTWEVPDGPDP 325
+ ++ + +PDG P
Sbjct: 699 PKPDADGFIMVYLPDGQSP 717
Score = 56.6 bits (135), Expect = 1e-07
Identities = 91/380 (23%), Positives = 137/380 (36%), Gaps = 46/380 (12%)
Query: 216 VEAQTTSSISLSWEVPDGTDPQNSTYCVQCTG---DGGRTETRNTTDTRVTVDGLGPGSL 272
V T +SI+++W+ G S Y ++ DG + T TR ++ GL P S
Sbjct: 327 VTENTATSITITWD--SGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 384
Query: 273 YTCSVWVEKDGVNS--------SVEIVTSATAP-NPVRNLTVEAQTNSSIALTWEVPDGP 323
Y +WV VNS SV T AP + RN+ + +++ + WE P P
Sbjct: 385 Y--EIWVS--AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEP 440
Query: 324 DPQNSTYGVEYTGDGGRAGTRSTAHT-----NITVDRLEPGCLYVFSVW----VGKNGIN 374
+ Y V YT + H TV L Y V VG ++
Sbjct: 441 NGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS 500
Query: 375 SSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRN 434
+ + P NL E ++ +SI L W P Y G
Sbjct: 501 DPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTF 560
Query: 435 TTNTSVTAERLEPGTLYTFSVWAEKNGARGS-----RQNVSISTVPNAVTSLSKQDWTNS 489
TS E L+P T Y F + A G+ RQ S P + + +
Sbjct: 561 DPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPK---NFKVKMIMKT 617
Query: 490 TIALRWTAPQGPGQSSYSYWVSWVREGMT---DPRTQSTSGTDITLKELEAGSLYHLTVW 546
++ L W P S Y + + G+T D RT T + L+ + Y+ +
Sbjct: 618 SVLLSWEFPDN-YNSPTPYKIQY--NGLTLDVDGRT-----TKKLITHLKPHTFYNFVLT 669
Query: 547 AERNEVRGYNSTLTAATAPN 566
+ + G T+TA TA N
Sbjct: 670 NRGSSLGGLQQTVTAWTAFN 689
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 231 bits (588), Expect = 4e-60
Identities = 118/284 (41%), Positives = 170/284 (59%), Gaps = 11/284 (3%)
Query: 800 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859
I D H+ + + GF ++Y+ G S S VA +N AKNRY N++ YD S
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESF-FEGQSASWDVAKKDQNRAKNRYGNIIAYDHS 926
Query: 860 RVPLKPIHEEPGSDYINASFMP------GLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 913
RV L+P+ ++P SDYINA+++ G P +IATQGP+ +TV DFWR++W++QS
Sbjct: 927 RVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSA 986
Query: 914 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKT 973
+VM+TN +E GRVKC YWP D++ +G +VT V E + + VR L + +
Sbjct: 987 CIVMVTNLVEVGRVKCYKYWPDDTE--VYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEI 1044
Query: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
V+QFH+ WPDHGVP LL+F R ++ L GP +VHCSAG GRTG I +
Sbjct: 1045 REVKQFHFTGWPDHGVPYHATGLLSFIRRVK--LSNPPSAGPIVVHCSAGAGRTGCYIVI 1102
Query: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
D++L + EG++ ++ V+ +R R MVQTE QY+F+H IL
Sbjct: 1103 DIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL 1146
Score = 125 bits (314), Expect = 2e-28
Identities = 87/287 (30%), Positives = 144/287 (50%), Gaps = 13/287 (4%)
Query: 805 FADHVRKNERDSNCGFADKYQQLSLVG---HSQSQMVASASENNAKNRYRNVLPYDWSRV 861
+ D +R + + ++ D++Q L+ V ++ +A N+ KNR+ ++LP D
Sbjct: 1165 YFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLP 1224
Query: 862 PLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNC 921
L I E S+YINA+ M P FI TQ PLP TV DFWRLV++ ++VML
Sbjct: 1225 FLITIDGE-SSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV 1283
Query: 922 -MEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVR--ELLLLQVEEQKTLSVRQ 978
+ G C YWP + +G ++V + + + R + L ++ L V+Q
Sbjct: 1284 DLSQG---CPQYWPEEGM-LRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQ 1339
Query: 979 FHYQAWPDH-GVPSSPDTLLAFWRMLRQWLDQTMEG-GPPIVHCSAGVGRTGTLIALDVL 1036
F Y W H VP S + L + +W ++ EG G I+HC G GR+G A+ ++
Sbjct: 1340 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1399
Query: 1037 LRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQS 1083
+ ++ + ++ F V+ +R S+P MV+ QY F + L +L+ S
Sbjct: 1400 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS 1446
Score = 34.7 bits (78), Expect = 0.52
Identities = 31/124 (25%), Positives = 48/124 (38%), Gaps = 15/124 (12%)
Query: 565 PNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSR 624
P V LQ T +N + L WK P DP+ + Y + ++S R DP
Sbjct: 492 PVPVKSLQG-TSFENKIFLNWKEPLDPNGIITQYEISYSS----IRSFDPAVPVAGPPQT 546
Query: 625 TNETWYKVE----ALEPGTLYNFTVWAER------NDVASSTQSLCASTYPDTVTITSCV 674
+ W L PGT Y F + A + T ++ A T PD + + +
Sbjct: 547 VSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASL 606
Query: 675 STSA 678
+ +A
Sbjct: 607 NETA 610
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 223 bits (569), Expect = 6e-58
Identities = 128/365 (35%), Positives = 190/365 (52%), Gaps = 45/365 (12%)
Query: 754 VIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP--------------------ELRDLV 793
VI + + I++ +L++ K +K+K +P E+R +
Sbjct: 1286 VIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRIN 1345
Query: 794 FSSPGD---------------------IPAEDFADHVRKNERDSNCGFADKYQQLSLVGH 832
F +P IP D A+H + + + + + +Y+ + G
Sbjct: 1346 FQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID-PGQ 1404
Query: 833 SQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIAT 892
+ ++ N KNRY NV+ YD SRV L+PI GSDYINA+++ G +IAT
Sbjct: 1405 QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIAT 1464
Query: 893 QGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGE 952
QGPLP+T GDFWR+VWEQ+S T+VM+T E R+KC+ YWP + T+G ++VTL+
Sbjct: 1465 QGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDT 1523
Query: 953 EVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTME 1012
+ + VR L + + VRQF + AWPDHGVP P LAF R ++ +
Sbjct: 1524 IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPD 1581
Query: 1013 GGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFL 1072
GP +VHCSAGVGRTG I +D +L +++ E + + V MR R MVQTE QY F+
Sbjct: 1582 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1641
Query: 1073 HQCIL 1077
H+ +L
Sbjct: 1642 HEALL 1646
Score = 199 bits (505), Expect = 2e-50
Identities = 101/249 (40%), Positives = 148/249 (59%), Gaps = 1/249 (0%)
Query: 832 HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIA 891
H+ + A+ N KNR N++PY+ +RV L+PI GSDYINASF+ G + +IA
Sbjct: 1693 HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIA 1752
Query: 892 TQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVG 951
TQGPL +T DFWR++WE S +VMLT E GR KC YWP + + + + V +
Sbjct: 1753 TQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMA 1811
Query: 952 EEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTM 1011
E M + +RE + + ++ +VRQF + WP+ GVP S + + F + + +Q
Sbjct: 1812 EYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1871
Query: 1012 EGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVF 1071
+ GP VHCSAGVGRTG I L ++L +++ EG++ F V+ +R RP MVQTE +Y F
Sbjct: 1872 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1931
Query: 1072 LHQCILRFL 1080
+Q L +L
Sbjct: 1932 CYQAALEYL 1940
Score = 62.4 bits (150), Expect = 2e-09
Identities = 152/722 (21%), Positives = 256/722 (35%), Gaps = 106/722 (14%)
Query: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG----GTTETRN 78
TG +APA P RN+ + +++ + WE P + Y V T + G + N
Sbjct: 421 TGEQAPASAP-RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHN 479
Query: 79 TTATNVTVDG-LGPGSLYTCSVW----VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNS 133
+ +T G L YT V V ++ + T P NLR EA++ +
Sbjct: 480 VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET 539
Query: 134 SIALTWEVPDGPDPQNSTYGVEY---TGDGGR-AGTRSTAHTNITVDGLEPGCLYAFSMW 189
SI L+W P Q S E GD GR G T+ V+ L+P YAF +
Sbjct: 540 SITLSW----SPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLA 595
Query: 190 V-GKNGINSSRETRNATTAHN----PVRNLRVEAQTTSSISLSWEVPDGTDPQNST--YC 242
G+ + T + P ++++ + +++I +SW P + Y
Sbjct: 596 ARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYS 655
Query: 243 VQCTGDGGRTETRN------TTDTRVTVDGLGPGSLYTCSVWVEKD---GVNSSVEIV-T 292
V+ G T T++ ++ L + Y + + G SS +V T
Sbjct: 656 VRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRT 715
Query: 293 SATAPN-PVRNLTVEAQTNSSIALTWEVPDGPDPQNST---YGVEYTG-DGGRA------ 341
P+ P R + EA ++I + W P P Q+ Y V Y +G A
Sbjct: 716 DEDVPSAPPRKVEAEALNATAIRVLWRSP-APGRQHGQIRGYQVHYVRMEGAEARGPPRI 774
Query: 342 ----------GTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPV-- 389
T TA + + L+P Y +V + +R V
Sbjct: 775 KDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLG 834
Query: 390 -RNLHMETQTNSSIALCWEVPDG-PYPQDYTYWVEYTGDGG---GTETRNTTNTSVTAER 444
L ++ S+ WE P G Q Y +++ + T + TA
Sbjct: 835 RPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASG 894
Query: 445 LEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQ------DWTNSTIALRWTAP 498
+ G Y F + A G G + + ++P Q + + T+ LRW P
Sbjct: 895 VHKGATYVFRLAARSRGGLG-EEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPP 953
Query: 499 QGPGQSS--YSYWVSWVREGMTDPRTQST--------SGTDITLKELEAGSLYHLTVWAE 548
++ Y V+ G P ++ + +TL+ L+ + Y L V A
Sbjct: 954 VPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAH 1013
Query: 549 RNEVRG-------YNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQ 601
G Y + L +P + + + K SV+L W+ P D ++ Y +Q
Sbjct: 1014 TRRGPGPFSPPVRYRTFLRDQVSPK---NFKVKMIMKTSVLLSWEFP-DNYNSPTPYKIQ 1069
Query: 602 WASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCA 661
+ N + T + L+P T YNF + + + Q++ A
Sbjct: 1070 Y--------------NGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTA 1115
Query: 662 ST 663
T
Sbjct: 1116 WT 1117
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 223 bits (568), Expect = 8e-58
Identities = 115/304 (37%), Positives = 172/304 (56%), Gaps = 10/304 (3%)
Query: 800 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859
I D H+ + + GF ++Y+ G S A EN KNRY N++ YD S
Sbjct: 880 IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 938
Query: 860 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 919
RV L+ I + SDYIN +++ G P +IATQGP+ +T+ DFWR+VW + + +++M+T
Sbjct: 939 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 998
Query: 920 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 979
N +E GRVKC YWP D++ + ++VTL+ E++ + +R + + + +RQF
Sbjct: 999 NLVEVGRVKCCKYWPDDTE--IYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQF 1056
Query: 980 HYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQ 1039
H+ WPDHGVP LL F R ++ GP +VHCSAG GRTG I +D++L
Sbjct: 1057 HFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1114
Query: 1040 LQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVEN 1099
+ EG++ ++ VR++R R MVQTE QYVF+H IL A + VP V +
Sbjct: 1115 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL-----EACLCGDTSVPASQVRS 1169
Query: 1100 LIYE 1103
L Y+
Sbjct: 1170 LYYD 1173
Score = 117 bits (294), Expect = 5e-26
Identities = 80/247 (32%), Positives = 122/247 (49%), Gaps = 8/247 (3%)
Query: 838 VASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLP 897
+A N+ KNR ++LP D L I E S+YINA+ M P FI TQ PLP
Sbjct: 1207 IALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLP 1265
Query: 898 QTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMEN 957
TV DFWRLV + ++VML + A C YWP ++ HG ++V V ++ E+
Sbjct: 1266 NTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP-ENGVHRHGPIQVEFVSADLEED 1322
Query: 958 WTVRELLLLQVEEQKT--LSVRQFHYQAWPDH-GVPSSPDTLLAFWRMLRQWLDQTMEG- 1013
R + + V+QF + WP + P S + L R + +W ++ G
Sbjct: 1323 IISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1382
Query: 1014 GPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLH 1073
G +VHC G GR+GT A+ ++ L+ + + F V+ +R ++P MV QY F +
Sbjct: 1383 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1442
Query: 1074 QCILRFL 1080
+ L +L
Sbjct: 1443 EVALEYL 1449
Score = 38.5 bits (88), Expect = 0.036
Identities = 115/499 (23%), Positives = 176/499 (35%), Gaps = 86/499 (17%)
Query: 332 VEY-TGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWV---GKNGINSSRET-RNATTAP 386
VEY T G + T+ + L+P Y SV + G+ G S R T
Sbjct: 318 VEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCA 377
Query: 387 NPVRN---LHMETQTNSSIALCWEVPDG---PYPQDYTYWVEYTGDGGGTET-------- 432
+P+R L + + I + WE P G Y V Y GG E
Sbjct: 378 DPMRGPRKLEVVEVKSRQITIRWE-PFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436
Query: 433 RNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSIST---VPNAVTSLSKQDWT-N 488
++ T L P T + + R Q + + T +P AV + S Q T
Sbjct: 437 TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496
Query: 489 STIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQ--STSG--------TDITLKELEAG 538
I L+W P Y +++ DP + SG T L G
Sbjct: 497 EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556
Query: 539 SLYHLTVWAERNEVRG---YNSTLTAATAPNEVTDLQNET---QTKNSVMLWWKAPGDPH 592
+ Y T+ A + G N T +AP+ + + ET QT N+V + K
Sbjct: 557 TTYSFTIRASTAKGFGPPATNQFTTKISAPS-MPAYELETPLNQTDNTVTVMLKPAHSRG 615
Query: 593 SQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETW--YKVEA-LEPGTLYNFTVWAER 649
+ + VY + + PRR T +T E Y V + +L N +
Sbjct: 616 APVSVYQIV-VEEERPRR-----------TKKTTEILKCYPVPIHFQNASLLNSQYYFAA 663
Query: 650 NDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFEL--EVGGQRGSQ 707
A S Q+ T D T GY W+ P Y+++ + + + +
Sbjct: 664 EFPADSLQAAQPFTIGDNKTYN-------GY-----WNTPLLPYKSYRIYFQAASRANGE 711
Query: 708 DRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLI 767
+ C V V G A P + K H+V IAG GILLF+I
Sbjct: 712 TKIDC---VQVATKGAATPKPVP-----EPEKQTDHTVK--------IAGVIAGILLFVI 755
Query: 768 LVGLLIFFLKRRNKKKQQK 786
+ ++ +K+R K++K
Sbjct: 756 IFLGVVLVMKKRKLAKKRK 774
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 223 bits (568), Expect = 8e-58
Identities = 115/304 (37%), Positives = 172/304 (56%), Gaps = 10/304 (3%)
Query: 800 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859
I D H+ + + GF ++Y+ G S A EN KNRY N++ YD S
Sbjct: 893 IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 951
Query: 860 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 919
RV L+ I + SDYIN +++ G P +IATQGP+ +T+ DFWR+VW + + +++M+T
Sbjct: 952 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 1011
Query: 920 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 979
N +E GRVKC YWP D++ + ++VTL+ E++ + +R + + + +RQF
Sbjct: 1012 NLVEVGRVKCCKYWPDDTE--IYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQF 1069
Query: 980 HYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQ 1039
H+ WPDHGVP LL F R ++ GP +VHCSAG GRTG I +D++L
Sbjct: 1070 HFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1127
Query: 1040 LQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVEN 1099
+ EG++ ++ VR++R R MVQTE QYVF+H IL A + VP V +
Sbjct: 1128 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL-----EACLCGDTSVPASQVRS 1182
Query: 1100 LIYE 1103
L Y+
Sbjct: 1183 LYYD 1186
Score = 117 bits (294), Expect = 5e-26
Identities = 80/247 (32%), Positives = 122/247 (49%), Gaps = 8/247 (3%)
Query: 838 VASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLP 897
+A N+ KNR ++LP D L I E S+YINA+ M P FI TQ PLP
Sbjct: 1220 IALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLP 1278
Query: 898 QTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMEN 957
TV DFWRLV + ++VML + A C YWP ++ HG ++V V ++ E+
Sbjct: 1279 NTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP-ENGVHRHGPIQVEFVSADLEED 1335
Query: 958 WTVRELLLLQVEEQKT--LSVRQFHYQAWPDH-GVPSSPDTLLAFWRMLRQWLDQTMEG- 1013
R + + V+QF + WP + P S + L R + +W ++ G
Sbjct: 1336 IISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1395
Query: 1014 GPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLH 1073
G +VHC G GR+GT A+ ++ L+ + + F V+ +R ++P MV QY F +
Sbjct: 1396 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1455
Query: 1074 QCILRFL 1080
+ L +L
Sbjct: 1456 EVALEYL 1462
Score = 38.5 bits (88), Expect = 0.036
Identities = 115/499 (23%), Positives = 176/499 (35%), Gaps = 86/499 (17%)
Query: 332 VEY-TGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWV---GKNGINSSRET-RNATTAP 386
VEY T G + T+ + L+P Y SV + G+ G S R T
Sbjct: 318 VEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCA 377
Query: 387 NPVRN---LHMETQTNSSIALCWEVPDG---PYPQDYTYWVEYTGDGGGTET-------- 432
+P+R L + + I + WE P G Y V Y GG E
Sbjct: 378 DPMRGPRKLEVVEVKSRQITIRWE-PFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436
Query: 433 RNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSIST---VPNAVTSLSKQDWT-N 488
++ T L P T + + R Q + + T +P AV + S Q T
Sbjct: 437 TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496
Query: 489 STIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQ--STSG--------TDITLKELEAG 538
I L+W P Y +++ DP + SG T L G
Sbjct: 497 EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556
Query: 539 SLYHLTVWAERNEVRG---YNSTLTAATAPNEVTDLQNET---QTKNSVMLWWKAPGDPH 592
+ Y T+ A + G N T +AP+ + + ET QT N+V + K
Sbjct: 557 TTYSFTIRASTAKGFGPPATNQFTTKISAPS-MPAYELETPLNQTDNTVTVMLKPAHSRG 615
Query: 593 SQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETW--YKVEA-LEPGTLYNFTVWAER 649
+ + VY + + PRR T +T E Y V + +L N +
Sbjct: 616 APVSVYQIV-VEEERPRR-----------TKKTTEILKCYPVPIHFQNASLLNSQYYFAA 663
Query: 650 NDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFEL--EVGGQRGSQ 707
A S Q+ T D T GY W+ P Y+++ + + + +
Sbjct: 664 EFPADSLQAAQPFTIGDNKTYN-------GY-----WNTPLLPYKSYRIYFQAASRANGE 711
Query: 708 DRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLI 767
+ C V V G A P + K H+V IAG GILLF+I
Sbjct: 712 TKIDC---VQVATKGAATPKPVP-----EPEKQTDHTVK--------IAGVIAGILLFVI 755
Query: 768 LVGLLIFFLKRRNKKKQQK 786
+ ++ +K+R K++K
Sbjct: 756 IFLGVVLVMKKRKLAKKRK 774
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 221 bits (564), Expect = 2e-57
Identities = 124/349 (35%), Positives = 193/349 (55%), Gaps = 26/349 (7%)
Query: 752 AGVIAGAFVGILLFLILVGLLIFFLKRRN-------------KKKQQKPELRDLVFSSPG 798
A ++A + + +++F+I+V ++ F K + + + +P+ L+ SP
Sbjct: 145 AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPS 204
Query: 799 D------IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRN 852
+P + + + + D N F +++ L + AS EN KNRY N
Sbjct: 205 TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
Query: 853 VLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQS 912
+LPYD SRV L P+ P SDYINASF+ G +FIA QGP +TV DFWR++WEQ +
Sbjct: 265 ILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT 324
Query: 913 HTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK 972
T+VM+TN E KC YWP D T+G++RV++ V+ ++TVR+ + QV +
Sbjct: 325 ATIVMVTNLKERKECKCAQYWP-DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMT 383
Query: 973 TLS----VRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTG 1028
+ QFH+ +WPD GVP +P +L F + ++ Q G +VHCSAGVGRTG
Sbjct: 384 NRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTG 441
Query: 1029 TLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL 1077
T + +D +L + +E + + FV ++R R MVQT+ QYVF++Q +L
Sbjct: 442 TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALL 490
Score = 199 bits (506), Expect = 1e-50
Identities = 102/267 (38%), Positives = 160/267 (59%), Gaps = 5/267 (1%)
Query: 816 SNCGFADKYQQLSLVGHSQSQM-VASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDY 874
SN G +++++L+ + +M + N KNR ++PY+++RV + E +DY
Sbjct: 520 SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDY 579
Query: 875 INASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWP 934
+NASF+ G +IA+QGPL T+ DFWR++WE +S ++VMLT E G+ KC YWP
Sbjct: 580 VNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP 639
Query: 935 LDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPD 994
D ++G + V L EE E++TVR+LL+ E K+ +RQFH+ WP+ G+PS
Sbjct: 640 SDGL-VSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGK 698
Query: 995 TLLAFWRMLRQWLDQTMEGGPPI-VHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVR 1053
+++ +++ Q G PI VHCSAG GRTGT AL +L ++++EG+L F V+
Sbjct: 699 GMISIIAAVQK--QQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVK 756
Query: 1054 KMRESRPLMVQTEAQYVFLHQCILRFL 1080
+R RP MVQT QY F ++ + ++
Sbjct: 757 SLRLQRPHMVQTLEQYEFCYKVVQEYI 783
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,461,601
Number of Sequences: 37866
Number of extensions: 2357056
Number of successful extensions: 7770
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 158
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 4377
Number of HSP's gapped (non-prelim): 1421
length of query: 1115
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1002
effective length of database: 13,968,660
effective search space: 13996597320
effective search space used: 13996597320
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.